id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-025495-udz9i0fw	Nowak, Jan K.	Lithium and coronaviral infections. A scoping review.	2020-04-03		.txt	text/plain	5329	296	46	The available evidence comes only from studies of cell cultures and indicates that lithium effectively inhibits coronaviral infections when administered at concentrations that are toxic to humans. "The available evidence comes only from studies of cell cultures and indicates that lithium effectively inhibits coronaviral infections when administered at concentrations that are toxic to humans." The prescription of lithium in the context of the current epidemic thus appears not to be supportable by the findings. Lithium also seemed to bring improvement in a proof-of-concept randomized double-blind placebo-controlled trial involving eleven healthy adults with recurrent HSV infections and in a randomized study of ten women with genital herpes conducted by the same research group from Philadelphia." Therefore it seems that in some instances lithium exhibits antiviral activity at concentrations, which are safe and maintained long-term (for years) in patients with affective disorders. The latter study gives hope that lithium may indeed be efficient at clinically relevant levels." In terms of discussion, the authors reviewed some existing literature and suggested a potential mechanism of reduced apoptosis by lithium, the glycogen synthase kinase 3-beta (GSK-3β) inhibitor.	./cache/cord-025495-udz9i0fw.txt	./txt/cord-025495-udz9i0fw.txt