id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-021977-yu0hrg6h	Pham, Phuong-Thu T.	Medical Management of the Kidney Transplant Recipient: Infections and Malignant Neoplasms	2010-12-27		.txt	text/plain	6923	390	34	Despite prophylactic therapy against common bacterial, viral, and opportunistic pathogens in the perioperative and postoperative period, infections are the second most common cause of death after cardiovascular disease (CVD) in renal transplant recipients. In the setting of immunosuppression, such viral infections may lead to the development of progressive liver disease or cirrhosis (HBV, HCV), BK nephropathy, post-transplantation lymphoproliferative disease (EBV), or squamous cell carcinoma (papillomavirus). 1 Sources of infections specific to recipients of renal transplant: perinephric fluid collections (e.g., lymphoceles, wound hematomas, urine leaks), indwelling urinary stents, or anatomic or functional genitourinary tract abnormalities (e.g., ureteral stricture, vesicoureteric reflux, neurogenic bladder blood, such as CMV DNA polymerase chain reaction (PCR) or pp65 antigenemia during surveillance studies. A suggested CMV prophylaxis protocol is shown in Figure 101 Clinical CMV disease is treated with intravenous ganciclovir (5 mg/kg twice daily for 3 weeks, dose adjusted for renal dysfunction) with reduction of immunosuppression, such as withholding of MMF.	./cache/cord-021977-yu0hrg6h.txt	./txt/cord-021977-yu0hrg6h.txt