id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-021424-kocwsyi7	Shannon, M. Frances	Genomic Approaches to the Host Response to Pathogens	2009-01-30		.txt	text/plain	7277	343	43	This activation process includes widespread changes in the gene expression profi le of the cells with hundreds of genes being either switched on or off in response to signals generated from the pathogen-detecting TLRs. The response of individual genes has been studied in minute detail for a handful of genes and while this has produced an understanding of some aspects of host response to infection it by no means gives us the total picture. Studies in both animal models and human populations have shown that infectious disease and the response of the host to a specifi c infection also has a complex genetic component ( Clementi and Di Gianantonio, 2006 ; Lipoldova and Demant, 2006 ; Marquet et al., 1996 ; Mira et al., 2004 ) . Expression profi ling studies have been used to investigate the differences in the host response to pathogenic and nonpathogenic strains of specifi c infectious agents.	./cache/cord-021424-kocwsyi7.txt	./txt/cord-021424-kocwsyi7.txt