id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018651-phb44k66	Hammoud, Dima A.	Neuroimaging	2017-05-26		.txt	text/plain	2940	133	34	A common approach is the use of recombinant viruses engineered to express a luciferase enzyme which allows performing longitudinal imaging, accurately determining the site(s) of infection, describing the temporal systemic dissemination of the virus, and eventually quantifying viral titers in various organs. More recent examples include the use of recombinant murine gammaherpesvirus 68 (MHV-68) expressing the firefly luciferase (Fluc) to monitor virus progression after CNS infection [11] and of recombinant Dengue virus, for realtime evaluation of replication kinetics in the brain of infected mice [12] . Other examples of reporter gene use include imaging of Toxoplasma gondii encephalitis with spatiotemporal demonstration of recrudescence of the infection from the CNS of immunocompromised mice [15] . More complex models such as the transgenic reporter mouse strain that expresses Fluc under the regulatory control of a concatenated Gal4 promoter [18] and the transgenic reporter mouse in which luciferase expression is driven by the nuclear factor B (NF-B)-dependent portion of the human immunodeficiency virus-1 long terminal repeat (HIV-1 LTR) [19] allowed the visualization of brain luciferase expression in response to adenovirus infection [18] and LPS intraperitoneal injection [19] , respectively.	./cache/cord-018651-phb44k66.txt	./txt/cord-018651-phb44k66.txt