id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018101-zd4v222b	Kawashima, Kent	Disease Outbreaks: Critical Biological Factors and Control Strategies	2016-05-31		.txt	text/plain	13128	624	45	We will briefly describe some pathogens that cause human disease and their transmission mechanisms before analyzing the SARS 2002-2003 epidemic as a case study of a modern urban epidemic. In general, fecal-oral and vector-borne diseases are infections transmitted through an environmental (water, food) or a biological (animal) carrier that extends transmission range to large distances, but other routes are also possible depending on the specific pathogen. In the following three subsections, we discuss theoretical results on three important aspect of disease outbreak: (1) the effect of "superspreaders" on the probability of outbreak, (2) the impact of control strategies such as isolation and quarantine, and (3) factors that affect the evolution of pathogen virulence. When the host population has a highly heterogeneously connected network, emergence of disease may be rare, but infections that survive stochastic extinction produce "explosive" epidemics similar to the case of SARS in 2002.	./cache/cord-018101-zd4v222b.txt	./txt/cord-018101-zd4v222b.txt