id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017583-72mbsib7	Devarajan, Padma V.	Infectious Diseases: Need for Targeted Drug Delivery	2014-09-01		.txt	text/plain	8877	531	32	The adaptive mechanisms of Mycobacterium tuberculosis to survive inside the macrophages are prevention of fusion of the phagosome with lysosomes by producing tryptophan-aspartate-containing coat protein (TACO). In case of Mycobacterium tuberculosis infection, alveolar macrophages (dust cells), along with dendritic cells engulf bacteria and exhibit innate as well as an adaptive immune response. Infection of macrophages leads to changes in the expression pattern of the concerned receptors, which can be exploited for targeted drug delivery employing nanocarriers. Table 3 .6 is a summary of the important receptors on macrophages and illustrative examples of ligands for the same that could play a role in designing targeted nanocarriers for infectious disease therapy. Targeted drug delivery to enhance effi cacy and shorten treatment duration in disseminated Mycobacterium avium infection in mi host factors infl uencing the preferential localization of sterically stabilized liposomes in klebsiella pneumoniae-infected rat lung tissue Targeted intracellular delivery of antituberculosis drugs to mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles	./cache/cord-017583-72mbsib7.txt	./txt/cord-017583-72mbsib7.txt