id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-013837-x95r6bz8	Chai, Qiyao	New insights into the evasion of host innate immunity by Mycobacterium tuberculosis	2020-07-29		.txt	text/plain	11189	603	31	In this review, we describe the emerging role of cytosolic nucleic acid-sensing pathways at the host–Mtb interface and summarize recently revealed mechanisms by which Mtb circumvents host cellular innate immune strategies such as membrane trafficking and integrity, cell death and autophagy. [19] [20] [21] The involvement of the cGAS-mediated DNA-sensing pathway in host anti-Mtb immunity is indicated by the findings that cGAS expression is upregulated and that cGAS is colocalized with mycobacteria in human TB lesions, and its deficiency impairs the induction of type I IFN responses and autophagy in Mtb-infected macrophages. 23 Therefore, specifically targeting mycobacterial ESX-1 products or host regulatory factors might enable the selective regulation of inflammasome and cGAS/STING pathway activation and, hence, contribute to the recovery of the equilibrium between Th1-type cytokine and type I IFN responses in TB patients to improve their anti-Mtb immunity.	./cache/cord-013837-x95r6bz8.txt	./txt/cord-013837-x95r6bz8.txt