id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011968-abd891ej	Lai, Yen-Chung	Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target	2020-06-12		.txt	text/plain	5705	268	38	Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. In another study, it was demonstrated that live DENV2-induced endoplasmic reticulum (ER) stress is required for autophagy activation, viral replication and pathogenesis in HuH-7 and A549 cells [57] . In our study, since UV-inactivated viral particles could not induce MIF secretion or expression, it is possible that DENV infection triggered RNA sensing or pattern recognition receptor (PRR) activation, which was followed by the release of preformed MIF from the cytosol through the vesicle trafficking secretory pathway. Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy Dengue virus nonstructural protein 1 induces vascular leakage through macrophage migration inhibitory factor and autophagy	./cache/cord-011968-abd891ej.txt	./txt/cord-011968-abd891ej.txt