id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010175-p2py9wau	Winter, Harland	GASTROINTESTINAL AND NUTRITIONAL PROBLEMS IN CHILDREN WITH IMMUNODEFICIENCY AND AIDS	1996-04-01		.txt	text/plain	4337	226	32	The observations that transmission is increased in women who were symptomatic or who had more advanced AIDS27 and that zidovudine therapy given during pregnancy reduces perinatal transmission3 suggest that viral burden is an important factor in vertical transmission; however, the effects of maternal nutritional status, micronutrient deficiency, or acute infection on viral replication are difficult to evaluate. Gastrointestinal bleeding is unusual in HIV-infected children, but, when present, it may be caused by focal ulcerations in the colon, stomach, small intestine, or esophagus from cytomegalovirus-induced disease. Many of the medications used to treat complications of HIV disease cause hepatocellular injury or cholestasis; however, infectious agents, such as hepatitis B, that cause hepatocellular injury by immune mechanisms have milder clinical courses in immunodeficient hosts.Z4 Preservation of immune function in HIV-infected children could account for the apparent increase in chronic active hepatitis in the pediatric population compared with the incidence in Although abnormalities in liver function tests are not diagnostic, they are beneficial as screening procedures.	./cache/cord-010175-p2py9wau.txt	./txt/cord-010175-p2py9wau.txt