id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009577-29u7pdpk	Gonzalez‐Scarano, F.	Molecular pathogenesis of neurotropic viral infections	2004-10-08		.txt	text/plain	6374	294	41	To cause systemic illness, a virus must first enter the host animal, undergo primary replication at a site near its portal of entry, and then ultimately spread to distant target tissues, such as the central nervous system (CNS). An infecting animal virus faces two main blocks to penetration of the CNS or any other specific target organ: (1) a variety of barriers prevent the free access of viruses to target cells, and (2) even when these barriers are ineffective, only certain cell types will support the internalization and replication of a particular virus. Monoclonal antibody variants have been used to map the antigenic sites of the influenza hemagglutinin 122, 76, 771 and have been used successfully to define important regions of the cellular binding proteins of rabies virus, reovirus, coronaviruses, and the California serogroup-all CNS pathogens. Viruses bind to the plasma membrane of susceptible target cells through specific receptors which may be proteins (HIV), lipids (vesicular stomatitis virus), or contain sialic acid (reovirus, influenza) [21, 641.	./cache/cord-009577-29u7pdpk.txt	./txt/cord-009577-29u7pdpk.txt