id author title date pages extension mime words sentences flesch summary cache txt cord-009380-5uptbat3 Evermann, James F. Diagnostic Medicine: The Challenge of Differentiating Infection from Disease and Making Sense for the Veterinary Clinician 2007-09-28 .txt text/plain 2922 173 44 Diagnostic medicine has taken on a new, broader meaning in the 1990s and reflects an expansion of clinical investigation from the diagnosis of disease to include detection of infection (Evermann, 1998) . Disease diagnosis has customarily used diagnostic assays for early recognition of disease and rapid implementation of therapy in an individual animal basis, and when appropriate use of corrective management (segregation, culling, vaccination, etc.) on a population basis. With a combination of more sensitive diagnostic assays, the veterinarian's concern to know the state of the preclinical infection, economic incentives to minimize disease by effectively controlling the infection, and concern over potential zoonotic diseases, laboratory diagnosis has taken on a different strategy. However, with early testing the problems of detecting cross-reacting viruses (feline enteric coronaviruses) increases, as does the question of whether the preclinical result accurately identifies an animal that is just infected or will progress onto disease (Evermann et al., 1995; Foley et al., 1997) . ./cache/cord-009380-5uptbat3.txt ./txt/cord-009380-5uptbat3.txt