id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007417-az8xd66p	Hansbro, Nicole G.	Understanding the mechanisms of viral induced asthma: New therapeutic directions	2008-01-29		.txt	text/plain	29677	1459	41	Whether an infection induces disease depends on viral (type (E.g. RSV, RV)), host (genetic susceptibility, age, immune responses) and environmental (allergen exposure, season) factors. With respect to allergy RSV infection might only trigger defective immunity in genetically susceptible individuals or that allergic inflammatory and immune responses may promote the influx of virus-specific cells into the airways increasing inflammation and AHR (Schwarze et al., 1999c) . Nevertheless most studies suggest that Th1 responses may result in viral clearance and mild symptoms whereas an aberrant bias towards a Th2 phenotype may lead to more intense RSV-induced disease and promote the development of asthma . Animal models have been used to determine if RSV can induce the development of asthma by triggering pro-asthmatic immune responses that lead to variable airflow obstruction and airway inflammation. Further studies are required to elucidate the links between infection, immune responses and susceptibility to chronic respiratory diseases and why some individuals but not others develop persistent wheeze and asthma.	./cache/cord-007417-az8xd66p.txt	./txt/cord-007417-az8xd66p.txt