id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006578-wv3wc0ct	Stevens, D. L.	Invasive streptococcal infections	2001		.txt	text/plain	8839	531	45	The risk for secondary cases is likely related to close or intimate contact and crowding, as well as host factors such as: (1) active viral infections such as varicella or influenza; (2) recent surgical wounds and childbirth (author's unpublished observations); (3) absence of type specific opsonic antibody against the group A streptococcus causing the index case; and (4) absence of neutralizing antibody against pyrogenic exotoxin A or B. 17 Streptococcal pyrogenic exotoxins A and B induce human mononuclear cells to synthesize not only TNFα 75 but also IL-1 76 and IL-6, [76] [77] [78] suggesting that TNF could mediate the fever, shock, and organ failure observed in patients with StrepTSS. Multi-locus enzyme electrophoresis demonstrates two patterns, which correspond to M-1 and M-3 type organisms that produce pyrogenic exotoxin A, a finding that fits epidemiologic studies implicating these strains in invasive group A streptococcal infections 54 in the United States.	./cache/cord-006578-wv3wc0ct.txt	./txt/cord-006578-wv3wc0ct.txt