id author title date pages extension mime words sentences flesch summary cache txt cord-006129-5rog0s98 Hemida, Maged Gomaa Exploiting the Therapeutic Potential of MicroRNAs in Viral Diseases: Expectations and Limitations 2012-08-16 .txt text/plain 7443 508 50 [12] Answering back, certain host miRNAs alter the cell gene expression to defend the cells against the viral infection by interfering with viral proteins or other cellular factors as a type of immune response against these particular viruses. [40] These virus-encoded miRNAs play important roles in the establishment of latent infection, as well as the pathogenesis of virally induced diseases. According to the most recent studies, herpesviruses utilize their encoded miRNAs in a wide range of biologic functions, such as inhibition of apoptosis, immune evasion, control of cellular proliferation, and regulation of viral replication. [58] Downregulation of UL114 protein, using miR-UL112-1, results in inhibition of viral DNA replication and subsequently triggers the latent phase of infection, making the virus able to evade the host immune system. ./cache/cord-006129-5rog0s98.txt ./txt/cord-006129-5rog0s98.txt