id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004247-lagv3tp7	Hooft van Huijsduijnen, Rob	Reassessing therapeutic antibodies for neglected and tropical diseases	2020-01-30		.txt	text/plain	6756	314	42	This mAb was protective in an in vitro, antigen-dependent, cellular cytotoxicity assay with rat macrophages or eosinophils and also in vivo during the early phase of infection Second, beyond the cell-surface proteins, schistosomes also express a large number of glycans as part of their glycoprotein and glycolipid repertoire, and an antibody response against those glycans is mounted by the infected host [80] . In addition to antibodies that directly target and inhibit the fungal pathogen, mAbs can be directed to checkpoints that control the host immune response. In addition to highlighting the potential of mAbs as therapeutics, these studies have demonstrated the diversity of inhibitory actions that mAbs can perform on cryptococcal cells, which can include opsonization and increased phagocytosis, inhibition of fungal growth, capsular polysaccharide release and biofilm formation, antibody-mediated target cleavage, and augmentation of the host response [104] [105] [106] [107] .	./cache/cord-004247-lagv3tp7.txt	./txt/cord-004247-lagv3tp7.txt