id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003598-m2fsrwvw	Elbahesh, Husni	Response Modifiers: Tweaking the Immune Response Against Influenza A Virus	2019-04-12		.txt	text/plain	4171	225	35	Like many viruses, IAV is reliant on host factors and signaling-pathways for its replication, which could potentially offer alternative options to treat infections. Clinical treatment options for severe influenza virus infections remain limited and relying heavily on the administration of antiviral neuraminidase inhibitors (NAIs) and supportive critical care (9). While virus-targeted therapies remain the standard approach, IV's mutability and adaptation to current antivirals has highlighted the need for new therapeutic options that target host factors that regulate IV infections and resulting immune responses. Host kinases regulate not only IAV entry and replication but also initiate antiviral signaling cascades that regulate expression of pro-inflammatory chemokines and cytokines during infections and present viable targets for intervention (24, (49) (50) (51) (52) (53) (54) (55) (56) (57) (58) . Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection	./cache/cord-003598-m2fsrwvw.txt	./txt/cord-003598-m2fsrwvw.txt