id sid tid token lemma pos cord-303322-d69o3z8d 1 1 key key JJ cord-303322-d69o3z8d 1 2 : : : cord-303322-d69o3z8d 1 3 cord-303322-d69o3z8d cord-303322-d69o3z8d NNP cord-303322-d69o3z8d 1 4 authors author NNS cord-303322-d69o3z8d 1 5 : : : cord-303322-d69o3z8d 1 6 Chang Chang NNP cord-303322-d69o3z8d 1 7 , , , cord-303322-d69o3z8d 1 8 Anne Anne NNP cord-303322-d69o3z8d 1 9 B B NNP cord-303322-d69o3z8d 1 10 ; ; : cord-303322-d69o3z8d 1 11 Grimwood Grimwood NNP cord-303322-d69o3z8d 1 12 , , , cord-303322-d69o3z8d 1 13 Keith Keith NNP cord-303322-d69o3z8d 1 14 ; ; : cord-303322-d69o3z8d 1 15 White White NNP cord-303322-d69o3z8d 1 16 , , , cord-303322-d69o3z8d 1 17 Andrew Andrew NNP cord-303322-d69o3z8d 1 18 V V NNP cord-303322-d69o3z8d 1 19 ; ; : cord-303322-d69o3z8d 1 20 Maclennan Maclennan NNP cord-303322-d69o3z8d 1 21 , , , cord-303322-d69o3z8d 1 22 Carolyn Carolyn NNP cord-303322-d69o3z8d 1 23 ; ; : cord-303322-d69o3z8d 1 24 Sloots Sloots NNP cord-303322-d69o3z8d 1 25 , , , cord-303322-d69o3z8d 1 26 Theo Theo NNP cord-303322-d69o3z8d 1 27 P P NNP cord-303322-d69o3z8d 1 28 ; ; : cord-303322-d69o3z8d 1 29 Sive Sive NNP cord-303322-d69o3z8d 1 30 , , , cord-303322-d69o3z8d 1 31 Alan Alan NNP cord-303322-d69o3z8d 1 32 ; ; : cord-303322-d69o3z8d 1 33 McCallum McCallum NNP cord-303322-d69o3z8d 1 34 , , , cord-303322-d69o3z8d 1 35 Gabrielle Gabrielle NNP cord-303322-d69o3z8d 1 36 B B NNP cord-303322-d69o3z8d 1 37 ; ; : cord-303322-d69o3z8d 1 38 Mackay Mackay NNP cord-303322-d69o3z8d 1 39 , , , cord-303322-d69o3z8d 1 40 Ian Ian NNP cord-303322-d69o3z8d 1 41 M M NNP cord-303322-d69o3z8d 1 42 ; ; : cord-303322-d69o3z8d 1 43 Morris Morris NNP cord-303322-d69o3z8d 1 44 , , , cord-303322-d69o3z8d 1 45 Peter Peter NNP cord-303322-d69o3z8d 1 46 S S NNP cord-303322-d69o3z8d 1 47 title title NN cord-303322-d69o3z8d 1 48 : : : cord-303322-d69o3z8d 2 1 Randomized randomized JJ cord-303322-d69o3z8d 2 2 placebo placebo NN cord-303322-d69o3z8d 2 3 - - HYPH cord-303322-d69o3z8d 2 4 controlled control VBN cord-303322-d69o3z8d 2 5 trial trial NN cord-303322-d69o3z8d 2 6 on on IN cord-303322-d69o3z8d 2 7 azithromycin azithromycin NNP cord-303322-d69o3z8d 2 8 to to TO cord-303322-d69o3z8d 2 9 reduce reduce VB cord-303322-d69o3z8d 2 10 the the DT cord-303322-d69o3z8d 2 11 morbidity morbidity NN cord-303322-d69o3z8d 2 12 of of IN cord-303322-d69o3z8d 2 13 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 2 14 in in IN cord-303322-d69o3z8d 2 15 Indigenous indigenous JJ cord-303322-d69o3z8d 2 16 Australian australian JJ cord-303322-d69o3z8d 2 17 infants infant NNS cord-303322-d69o3z8d 2 18 : : : cord-303322-d69o3z8d 3 1 rationale rationale NN cord-303322-d69o3z8d 3 2 and and CC cord-303322-d69o3z8d 3 3 protocol protocol NN cord-303322-d69o3z8d 3 4 date date NN cord-303322-d69o3z8d 3 5 : : : cord-303322-d69o3z8d 3 6 2011 2011 CD cord-303322-d69o3z8d 3 7 - - HYPH cord-303322-d69o3z8d 3 8 04 04 CD cord-303322-d69o3z8d 3 9 - - SYM cord-303322-d69o3z8d 3 10 14 14 CD cord-303322-d69o3z8d 3 11 journal journal NN cord-303322-d69o3z8d 3 12 : : : cord-303322-d69o3z8d 4 1 Trials trial NNS cord-303322-d69o3z8d 4 2 DOI DOI NNP cord-303322-d69o3z8d 4 3 : : : cord-303322-d69o3z8d 4 4 10.1186/1745 10.1186/1745 CD cord-303322-d69o3z8d 4 5 - - HYPH cord-303322-d69o3z8d 4 6 6215 6215 CD cord-303322-d69o3z8d 4 7 - - HYPH cord-303322-d69o3z8d 4 8 12 12 CD cord-303322-d69o3z8d 4 9 - - SYM cord-303322-d69o3z8d 4 10 94 94 CD cord-303322-d69o3z8d 5 1 sha sha NNP cord-303322-d69o3z8d 5 2 : : : cord-303322-d69o3z8d 5 3 b34cc3d570e41a80c01088f73600357cf071a4da b34cc3d570e41a80c01088f73600357cf071a4da NNP cord-303322-d69o3z8d 5 4 doc_id doc_id CD cord-303322-d69o3z8d 5 5 : : : cord-303322-d69o3z8d 5 6 303322 303322 CD cord-303322-d69o3z8d 5 7 cord_uid cord_uid NNS cord-303322-d69o3z8d 5 8 : : : cord-303322-d69o3z8d 5 9 d69o3z8d d69o3z8d VB cord-303322-d69o3z8d 5 10 BACKGROUND background NN cord-303322-d69o3z8d 5 11 : : : cord-303322-d69o3z8d 6 1 Acute acute JJ cord-303322-d69o3z8d 6 2 lower low JJR cord-303322-d69o3z8d 6 3 respiratory respiratory JJ cord-303322-d69o3z8d 6 4 infections infection NNS cord-303322-d69o3z8d 6 5 are be VBP cord-303322-d69o3z8d 6 6 the the DT cord-303322-d69o3z8d 6 7 commonest common JJS cord-303322-d69o3z8d 6 8 cause cause NN cord-303322-d69o3z8d 6 9 of of IN cord-303322-d69o3z8d 6 10 morbidity morbidity NN cord-303322-d69o3z8d 6 11 and and CC cord-303322-d69o3z8d 6 12 potentially potentially RB cord-303322-d69o3z8d 6 13 preventable preventable JJ cord-303322-d69o3z8d 6 14 mortality mortality NN cord-303322-d69o3z8d 6 15 in in IN cord-303322-d69o3z8d 6 16 Indigenous indigenous JJ cord-303322-d69o3z8d 6 17 infants infant NNS cord-303322-d69o3z8d 6 18 . . . cord-303322-d69o3z8d 7 1 Infancy infancy NN cord-303322-d69o3z8d 7 2 is be VBZ cord-303322-d69o3z8d 7 3 also also RB cord-303322-d69o3z8d 7 4 a a DT cord-303322-d69o3z8d 7 5 critical critical JJ cord-303322-d69o3z8d 7 6 time time NN cord-303322-d69o3z8d 7 7 for for IN cord-303322-d69o3z8d 7 8 post post JJ cord-303322-d69o3z8d 7 9 - - JJ cord-303322-d69o3z8d 7 10 natal natal JJ cord-303322-d69o3z8d 7 11 lung lung NN cord-303322-d69o3z8d 7 12 growth growth NN cord-303322-d69o3z8d 7 13 and and CC cord-303322-d69o3z8d 7 14 development development NN cord-303322-d69o3z8d 7 15 . . . cord-303322-d69o3z8d 8 1 Severe severe JJ cord-303322-d69o3z8d 8 2 or or CC cord-303322-d69o3z8d 8 3 repeated repeat VBN cord-303322-d69o3z8d 8 4 lower low JJR cord-303322-d69o3z8d 8 5 airway airway NN cord-303322-d69o3z8d 8 6 injury injury NN cord-303322-d69o3z8d 8 7 in in IN cord-303322-d69o3z8d 8 8 very very RB cord-303322-d69o3z8d 8 9 young young JJ cord-303322-d69o3z8d 8 10 children child NNS cord-303322-d69o3z8d 8 11 likely likely RB cord-303322-d69o3z8d 8 12 increases increase VBZ cord-303322-d69o3z8d 8 13 the the DT cord-303322-d69o3z8d 8 14 likelihood likelihood NN cord-303322-d69o3z8d 8 15 of of IN cord-303322-d69o3z8d 8 16 chronic chronic JJ cord-303322-d69o3z8d 8 17 pulmonary pulmonary JJ cord-303322-d69o3z8d 8 18 disorders disorder NNS cord-303322-d69o3z8d 8 19 later later RB cord-303322-d69o3z8d 8 20 in in IN cord-303322-d69o3z8d 8 21 life life NN cord-303322-d69o3z8d 8 22 . . . cord-303322-d69o3z8d 9 1 Globally globally RB cord-303322-d69o3z8d 9 2 , , , cord-303322-d69o3z8d 9 3 bronchiolitis bronchiolitis NNP cord-303322-d69o3z8d 9 4 is be VBZ cord-303322-d69o3z8d 9 5 the the DT cord-303322-d69o3z8d 9 6 most most RBS cord-303322-d69o3z8d 9 7 common common JJ cord-303322-d69o3z8d 9 8 form form NN cord-303322-d69o3z8d 9 9 of of IN cord-303322-d69o3z8d 9 10 acute acute JJ cord-303322-d69o3z8d 9 11 lower low JJR cord-303322-d69o3z8d 9 12 respiratory respiratory JJ cord-303322-d69o3z8d 9 13 infections infection NNS cord-303322-d69o3z8d 9 14 during during IN cord-303322-d69o3z8d 9 15 infancy infancy NN cord-303322-d69o3z8d 9 16 . . . cord-303322-d69o3z8d 10 1 Compared compare VBN cord-303322-d69o3z8d 10 2 with with IN cord-303322-d69o3z8d 10 3 non non JJ cord-303322-d69o3z8d 10 4 - - JJ cord-303322-d69o3z8d 10 5 Indigenous indigenous JJ cord-303322-d69o3z8d 10 6 Australian australian JJ cord-303322-d69o3z8d 10 7 infants infant NNS cord-303322-d69o3z8d 10 8 , , , cord-303322-d69o3z8d 10 9 Indigenous indigenous JJ cord-303322-d69o3z8d 10 10 infants infant NNS cord-303322-d69o3z8d 10 11 have have VBP cord-303322-d69o3z8d 10 12 greater great JJR cord-303322-d69o3z8d 10 13 bacterial bacterial JJ cord-303322-d69o3z8d 10 14 density density NN cord-303322-d69o3z8d 10 15 in in IN cord-303322-d69o3z8d 10 16 their -PRON- PRP$ cord-303322-d69o3z8d 10 17 upper upper JJ cord-303322-d69o3z8d 10 18 airways airway NNS cord-303322-d69o3z8d 10 19 and and CC cord-303322-d69o3z8d 10 20 more more RBR cord-303322-d69o3z8d 10 21 severe severe JJ cord-303322-d69o3z8d 10 22 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 10 23 episodes episode NNS cord-303322-d69o3z8d 10 24 . . . cord-303322-d69o3z8d 11 1 Our -PRON- PRP$ cord-303322-d69o3z8d 11 2 study study NN cord-303322-d69o3z8d 11 3 tests test VBZ cord-303322-d69o3z8d 11 4 the the DT cord-303322-d69o3z8d 11 5 hypothesis hypothesis NN cord-303322-d69o3z8d 11 6 that that IN cord-303322-d69o3z8d 11 7 the the DT cord-303322-d69o3z8d 11 8 anti anti JJ cord-303322-d69o3z8d 11 9 - - JJ cord-303322-d69o3z8d 11 10 microbial microbial JJ cord-303322-d69o3z8d 11 11 and and CC cord-303322-d69o3z8d 11 12 anti anti JJ cord-303322-d69o3z8d 11 13 - - JJ cord-303322-d69o3z8d 11 14 inflammatory inflammatory JJ cord-303322-d69o3z8d 11 15 properties property NNS cord-303322-d69o3z8d 11 16 of of IN cord-303322-d69o3z8d 11 17 azithromycin azithromycin NN cord-303322-d69o3z8d 11 18 , , , cord-303322-d69o3z8d 11 19 improve improve VB cord-303322-d69o3z8d 11 20 the the DT cord-303322-d69o3z8d 11 21 clinical clinical JJ cord-303322-d69o3z8d 11 22 outcomes outcome NNS cord-303322-d69o3z8d 11 23 of of IN cord-303322-d69o3z8d 11 24 Indigenous indigenous JJ cord-303322-d69o3z8d 11 25 Australian australian JJ cord-303322-d69o3z8d 11 26 infants infant NNS cord-303322-d69o3z8d 11 27 hospitalised hospitalise VBN cord-303322-d69o3z8d 11 28 with with IN cord-303322-d69o3z8d 11 29 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 11 30 . . . cord-303322-d69o3z8d 12 1 METHODS methods NN cord-303322-d69o3z8d 12 2 : : : cord-303322-d69o3z8d 13 1 We -PRON- PRP cord-303322-d69o3z8d 13 2 are be VBP cord-303322-d69o3z8d 13 3 conducting conduct VBG cord-303322-d69o3z8d 13 4 a a DT cord-303322-d69o3z8d 13 5 dual dual JJ cord-303322-d69o3z8d 13 6 centre centre NN cord-303322-d69o3z8d 13 7 , , , cord-303322-d69o3z8d 13 8 randomised randomised JJ cord-303322-d69o3z8d 13 9 , , , cord-303322-d69o3z8d 13 10 double double JJ cord-303322-d69o3z8d 13 11 - - HYPH cord-303322-d69o3z8d 13 12 blind blind JJ cord-303322-d69o3z8d 13 13 , , , cord-303322-d69o3z8d 13 14 placebo placebo NN cord-303322-d69o3z8d 13 15 - - HYPH cord-303322-d69o3z8d 13 16 controlled control VBN cord-303322-d69o3z8d 13 17 , , , cord-303322-d69o3z8d 13 18 parallel parallel JJ cord-303322-d69o3z8d 13 19 group group NN cord-303322-d69o3z8d 13 20 trial trial NN cord-303322-d69o3z8d 13 21 in in IN cord-303322-d69o3z8d 13 22 northern northern JJ cord-303322-d69o3z8d 13 23 Australia Australia NNP cord-303322-d69o3z8d 13 24 . . . cord-303322-d69o3z8d 14 1 Indigenous indigenous JJ cord-303322-d69o3z8d 14 2 infants infant NNS cord-303322-d69o3z8d 14 3 ( ( -LRB- cord-303322-d69o3z8d 14 4 aged aged JJ cord-303322-d69o3z8d 14 5 ≤ ≤ NN cord-303322-d69o3z8d 14 6 24-months 24-months CD cord-303322-d69o3z8d 14 7 , , , cord-303322-d69o3z8d 14 8 expected expect VBN cord-303322-d69o3z8d 14 9 number number NN cord-303322-d69o3z8d 14 10 = = SYM cord-303322-d69o3z8d 14 11 200 200 CD cord-303322-d69o3z8d 14 12 ) ) -RRB- cord-303322-d69o3z8d 14 13 admitted admit VBN cord-303322-d69o3z8d 14 14 to to IN cord-303322-d69o3z8d 14 15 one one CD cord-303322-d69o3z8d 14 16 of of IN cord-303322-d69o3z8d 14 17 two two CD cord-303322-d69o3z8d 14 18 regional regional JJ cord-303322-d69o3z8d 14 19 hospitals hospital NNS cord-303322-d69o3z8d 14 20 ( ( -LRB- cord-303322-d69o3z8d 14 21 Darwin Darwin NNP cord-303322-d69o3z8d 14 22 , , , cord-303322-d69o3z8d 14 23 Northern Northern NNP cord-303322-d69o3z8d 14 24 Territory Territory NNP cord-303322-d69o3z8d 14 25 and and CC cord-303322-d69o3z8d 14 26 Townsville Townsville NNP cord-303322-d69o3z8d 14 27 , , , cord-303322-d69o3z8d 14 28 Queensland Queensland NNP cord-303322-d69o3z8d 14 29 ) ) -RRB- cord-303322-d69o3z8d 14 30 with with IN cord-303322-d69o3z8d 14 31 a a DT cord-303322-d69o3z8d 14 32 clinical clinical JJ cord-303322-d69o3z8d 14 33 diagnosis diagnosis NN cord-303322-d69o3z8d 14 34 of of IN cord-303322-d69o3z8d 14 35 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 14 36 and and CC cord-303322-d69o3z8d 14 37 fulfilling fulfil VBG cord-303322-d69o3z8d 14 38 inclusion inclusion NN cord-303322-d69o3z8d 14 39 criteria criterion NNS cord-303322-d69o3z8d 14 40 are be VBP cord-303322-d69o3z8d 14 41 randomised randomised JJ cord-303322-d69o3z8d 14 42 ( ( -LRB- cord-303322-d69o3z8d 14 43 allocation allocation NN cord-303322-d69o3z8d 14 44 concealed conceal VBN cord-303322-d69o3z8d 14 45 ) ) -RRB- cord-303322-d69o3z8d 14 46 to to IN cord-303322-d69o3z8d 14 47 either either CC cord-303322-d69o3z8d 14 48 azithromycin azithromycin NNP cord-303322-d69o3z8d 14 49 ( ( -LRB- cord-303322-d69o3z8d 14 50 30 30 CD cord-303322-d69o3z8d 14 51 mg mg NN cord-303322-d69o3z8d 14 52 / / SYM cord-303322-d69o3z8d 14 53 kg kg NN cord-303322-d69o3z8d 14 54 / / SYM cord-303322-d69o3z8d 14 55 dose dose NN cord-303322-d69o3z8d 14 56 ) ) -RRB- cord-303322-d69o3z8d 14 57 or or CC cord-303322-d69o3z8d 14 58 placebo placebo NN cord-303322-d69o3z8d 15 1 administered administer VBN cord-303322-d69o3z8d 15 2 once once RB cord-303322-d69o3z8d 15 3 weekly weekly RB cord-303322-d69o3z8d 15 4 for for IN cord-303322-d69o3z8d 15 5 three three CD cord-303322-d69o3z8d 15 6 doses dose NNS cord-303322-d69o3z8d 15 7 . . . cord-303322-d69o3z8d 16 1 Clinical clinical JJ cord-303322-d69o3z8d 16 2 data datum NNS cord-303322-d69o3z8d 16 3 are be VBP cord-303322-d69o3z8d 16 4 recorded record VBN cord-303322-d69o3z8d 16 5 twice twice RB cord-303322-d69o3z8d 16 6 daily daily JJ cord-303322-d69o3z8d 16 7 and and CC cord-303322-d69o3z8d 16 8 nasopharyngeal nasopharyngeal JJ cord-303322-d69o3z8d 16 9 swab swab NN cord-303322-d69o3z8d 16 10 are be VBP cord-303322-d69o3z8d 16 11 collected collect VBN cord-303322-d69o3z8d 16 12 at at IN cord-303322-d69o3z8d 16 13 enrolment enrolment NN cord-303322-d69o3z8d 16 14 and and CC cord-303322-d69o3z8d 16 15 at at IN cord-303322-d69o3z8d 16 16 the the DT cord-303322-d69o3z8d 16 17 time time NN cord-303322-d69o3z8d 16 18 of of IN cord-303322-d69o3z8d 16 19 discharge discharge NN cord-303322-d69o3z8d 16 20 from from IN cord-303322-d69o3z8d 16 21 hospital hospital NN cord-303322-d69o3z8d 16 22 . . . cord-303322-d69o3z8d 17 1 Primary primary JJ cord-303322-d69o3z8d 17 2 outcomes outcome NNS cord-303322-d69o3z8d 17 3 are be VBP cord-303322-d69o3z8d 17 4 ' ' `` cord-303322-d69o3z8d 17 5 length length NN cord-303322-d69o3z8d 17 6 of of IN cord-303322-d69o3z8d 17 7 oxygen oxygen NN cord-303322-d69o3z8d 17 8 requirement requirement NN cord-303322-d69o3z8d 17 9 ' ' '' cord-303322-d69o3z8d 17 10 and and CC cord-303322-d69o3z8d 17 11 ' ' '' cord-303322-d69o3z8d 17 12 duration duration NN cord-303322-d69o3z8d 17 13 of of IN cord-303322-d69o3z8d 17 14 stay stay NN cord-303322-d69o3z8d 17 15 , , , cord-303322-d69o3z8d 17 16 ' ' '' cord-303322-d69o3z8d 17 17 the the DT cord-303322-d69o3z8d 17 18 latter latter JJ cord-303322-d69o3z8d 17 19 based base VBN cord-303322-d69o3z8d 17 20 upon upon IN cord-303322-d69o3z8d 17 21 being be VBG cord-303322-d69o3z8d 17 22 judged judge VBN cord-303322-d69o3z8d 17 23 as as IN cord-303322-d69o3z8d 17 24 ' ' `` cord-303322-d69o3z8d 17 25 ready ready JJ cord-303322-d69o3z8d 17 26 for for IN cord-303322-d69o3z8d 17 27 respiratory respiratory JJ cord-303322-d69o3z8d 17 28 discharge discharge NN cord-303322-d69o3z8d 17 29 ' ' '' cord-303322-d69o3z8d 17 30 . . . cord-303322-d69o3z8d 18 1 The the DT cord-303322-d69o3z8d 18 2 main main JJ cord-303322-d69o3z8d 18 3 secondary secondary JJ cord-303322-d69o3z8d 18 4 outcome outcome NN cord-303322-d69o3z8d 18 5 is be VBZ cord-303322-d69o3z8d 18 6 readmission readmission NN cord-303322-d69o3z8d 18 7 for for IN cord-303322-d69o3z8d 18 8 a a DT cord-303322-d69o3z8d 18 9 respiratory respiratory JJ cord-303322-d69o3z8d 18 10 illness illness NN cord-303322-d69o3z8d 18 11 within within IN cord-303322-d69o3z8d 18 12 6-months 6-months CD cord-303322-d69o3z8d 18 13 of of IN cord-303322-d69o3z8d 18 14 leaving leave VBG cord-303322-d69o3z8d 18 15 hospital hospital NN cord-303322-d69o3z8d 18 16 . . . cord-303322-d69o3z8d 19 1 Descriptive descriptive JJ cord-303322-d69o3z8d 19 2 virological virological JJ cord-303322-d69o3z8d 19 3 and and CC cord-303322-d69o3z8d 19 4 bacteriological bacteriological JJ cord-303322-d69o3z8d 19 5 ( ( -LRB- cord-303322-d69o3z8d 19 6 including include VBG cord-303322-d69o3z8d 19 7 development development NN cord-303322-d69o3z8d 19 8 of of IN cord-303322-d69o3z8d 19 9 antibiotic antibiotic JJ cord-303322-d69o3z8d 19 10 resistance resistance NN cord-303322-d69o3z8d 19 11 ) ) -RRB- cord-303322-d69o3z8d 19 12 data datum NNS cord-303322-d69o3z8d 19 13 from from IN cord-303322-d69o3z8d 19 14 nasopharyngeal nasopharyngeal JJ cord-303322-d69o3z8d 19 15 samples sample NNS cord-303322-d69o3z8d 19 16 will will MD cord-303322-d69o3z8d 19 17 also also RB cord-303322-d69o3z8d 19 18 be be VB cord-303322-d69o3z8d 19 19 reported report VBN cord-303322-d69o3z8d 19 20 . . . cord-303322-d69o3z8d 20 1 DISCUSSION discussion NN cord-303322-d69o3z8d 20 2 : : : cord-303322-d69o3z8d 21 1 Two two CD cord-303322-d69o3z8d 21 2 published publish VBN cord-303322-d69o3z8d 21 3 studies study NNS cord-303322-d69o3z8d 21 4 , , , cord-303322-d69o3z8d 21 5 both both DT cord-303322-d69o3z8d 21 6 involving involve VBG cord-303322-d69o3z8d 21 7 different different JJ cord-303322-d69o3z8d 21 8 patient patient JJ cord-303322-d69o3z8d 21 9 populations population NNS cord-303322-d69o3z8d 21 10 and and CC cord-303322-d69o3z8d 21 11 settings setting NNS cord-303322-d69o3z8d 21 12 , , , cord-303322-d69o3z8d 21 13 as as RB cord-303322-d69o3z8d 21 14 well well RB cord-303322-d69o3z8d 21 15 as as IN cord-303322-d69o3z8d 21 16 different different JJ cord-303322-d69o3z8d 21 17 macrolide macrolide NN cord-303322-d69o3z8d 21 18 antibiotics antibiotic NNS cord-303322-d69o3z8d 21 19 and and CC cord-303322-d69o3z8d 21 20 treatment treatment NN cord-303322-d69o3z8d 21 21 duration duration NN cord-303322-d69o3z8d 21 22 , , , cord-303322-d69o3z8d 21 23 have have VBP cord-303322-d69o3z8d 21 24 produced produce VBN cord-303322-d69o3z8d 21 25 conflicting conflicting JJ cord-303322-d69o3z8d 21 26 results result NNS cord-303322-d69o3z8d 21 27 . . . cord-303322-d69o3z8d 22 1 Our -PRON- PRP$ cord-303322-d69o3z8d 22 2 randomised randomised JJ cord-303322-d69o3z8d 22 3 , , , cord-303322-d69o3z8d 22 4 placebo placebo NN cord-303322-d69o3z8d 22 5 - - HYPH cord-303322-d69o3z8d 22 6 controlled control VBN cord-303322-d69o3z8d 22 7 trial trial NN cord-303322-d69o3z8d 22 8 of of IN cord-303322-d69o3z8d 22 9 azithromycin azithromycin NN cord-303322-d69o3z8d 22 10 in in IN cord-303322-d69o3z8d 22 11 Indigenous indigenous JJ cord-303322-d69o3z8d 22 12 infants infant NNS cord-303322-d69o3z8d 22 13 hospitalised hospitalise VBN cord-303322-d69o3z8d 22 14 with with IN cord-303322-d69o3z8d 22 15 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 22 16 is be VBZ cord-303322-d69o3z8d 22 17 designed design VBN cord-303322-d69o3z8d 22 18 to to TO cord-303322-d69o3z8d 22 19 determine determine VB cord-303322-d69o3z8d 22 20 whether whether IN cord-303322-d69o3z8d 22 21 it -PRON- PRP cord-303322-d69o3z8d 22 22 can can MD cord-303322-d69o3z8d 22 23 reduce reduce VB cord-303322-d69o3z8d 22 24 short short JJ cord-303322-d69o3z8d 22 25 - - HYPH cord-303322-d69o3z8d 22 26 term term NN cord-303322-d69o3z8d 22 27 ( ( -LRB- cord-303322-d69o3z8d 22 28 and and CC cord-303322-d69o3z8d 22 29 potentially potentially RB cord-303322-d69o3z8d 22 30 long long JJ cord-303322-d69o3z8d 22 31 - - HYPH cord-303322-d69o3z8d 22 32 term term NN cord-303322-d69o3z8d 22 33 ) ) -RRB- cord-303322-d69o3z8d 22 34 morbidity morbidity NN cord-303322-d69o3z8d 22 35 from from IN cord-303322-d69o3z8d 22 36 respiratory respiratory JJ cord-303322-d69o3z8d 22 37 illness illness NN cord-303322-d69o3z8d 22 38 in in IN cord-303322-d69o3z8d 22 39 Australian australian JJ cord-303322-d69o3z8d 22 40 Indigenous indigenous JJ cord-303322-d69o3z8d 22 41 infants infant NNS cord-303322-d69o3z8d 22 42 who who WP cord-303322-d69o3z8d 22 43 are be VBP cord-303322-d69o3z8d 22 44 at at IN cord-303322-d69o3z8d 22 45 high high JJ cord-303322-d69o3z8d 22 46 risk risk NN cord-303322-d69o3z8d 22 47 of of IN cord-303322-d69o3z8d 22 48 developing develop VBG cord-303322-d69o3z8d 22 49 chronic chronic JJ cord-303322-d69o3z8d 22 50 respiratory respiratory JJ cord-303322-d69o3z8d 22 51 illness illness NN cord-303322-d69o3z8d 22 52 . . . cord-303322-d69o3z8d 23 1 If if IN cord-303322-d69o3z8d 23 2 azithromycin azithromycin NNP cord-303322-d69o3z8d 23 3 is be VBZ cord-303322-d69o3z8d 23 4 efficacious efficacious JJ cord-303322-d69o3z8d 23 5 in in IN cord-303322-d69o3z8d 23 6 reducing reduce VBG cord-303322-d69o3z8d 23 7 the the DT cord-303322-d69o3z8d 23 8 morbidly morbidly JJ cord-303322-d69o3z8d 23 9 of of IN cord-303322-d69o3z8d 23 10 Indigenous indigenous JJ cord-303322-d69o3z8d 23 11 infants infant NNS cord-303322-d69o3z8d 23 12 hospitalised hospitalise VBN cord-303322-d69o3z8d 23 13 with with IN cord-303322-d69o3z8d 23 14 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 23 15 , , , cord-303322-d69o3z8d 23 16 the the DT cord-303322-d69o3z8d 23 17 intervention intervention NN cord-303322-d69o3z8d 23 18 would would MD cord-303322-d69o3z8d 23 19 lead lead VB cord-303322-d69o3z8d 23 20 to to IN cord-303322-d69o3z8d 23 21 improved improve VBN cord-303322-d69o3z8d 23 22 short short JJ cord-303322-d69o3z8d 23 23 term term NN cord-303322-d69o3z8d 23 24 ( ( -LRB- cord-303322-d69o3z8d 23 25 and and CC cord-303322-d69o3z8d 23 26 possibly possibly RB cord-303322-d69o3z8d 23 27 long long JJ cord-303322-d69o3z8d 23 28 term term NN cord-303322-d69o3z8d 23 29 ) ) -RRB- cord-303322-d69o3z8d 23 30 health health NN cord-303322-d69o3z8d 23 31 benefits benefit NNS cord-303322-d69o3z8d 23 32 . . . cord-303322-d69o3z8d 24 1 TRIAL trial NN cord-303322-d69o3z8d 24 2 REGISTRATION registration NN cord-303322-d69o3z8d 24 3 : : : cord-303322-d69o3z8d 25 1 Australia Australia NNP cord-303322-d69o3z8d 25 2 and and CC cord-303322-d69o3z8d 25 3 New New NNP cord-303322-d69o3z8d 25 4 Zealand Zealand NNP cord-303322-d69o3z8d 26 1 Clinical clinical JJ cord-303322-d69o3z8d 26 2 Trials trial NNS cord-303322-d69o3z8d 26 3 Register Register NNP cord-303322-d69o3z8d 26 4 ( ( -LRB- cord-303322-d69o3z8d 26 5 ANZCTR ANZCTR NNP cord-303322-d69o3z8d 26 6 ) ) -RRB- cord-303322-d69o3z8d 26 7 : : : cord-303322-d69o3z8d 27 1 ACTRN12610000326099 actrn12610000326099 CD cord-303322-d69o3z8d 28 1 We -PRON- PRP cord-303322-d69o3z8d 28 2 are be VBP cord-303322-d69o3z8d 28 3 conducting conduct VBG cord-303322-d69o3z8d 28 4 a a DT cord-303322-d69o3z8d 28 5 dual dual JJ cord-303322-d69o3z8d 28 6 centre centre NN cord-303322-d69o3z8d 28 7 , , , cord-303322-d69o3z8d 28 8 randomised randomised JJ cord-303322-d69o3z8d 28 9 , , , cord-303322-d69o3z8d 28 10 double double JJ cord-303322-d69o3z8d 28 11 - - HYPH cord-303322-d69o3z8d 28 12 blind blind JJ cord-303322-d69o3z8d 28 13 , , , cord-303322-d69o3z8d 28 14 placebo placebo NN cord-303322-d69o3z8d 28 15 - - HYPH cord-303322-d69o3z8d 28 16 controlled control VBN cord-303322-d69o3z8d 28 17 , , , cord-303322-d69o3z8d 28 18 parallel parallel JJ cord-303322-d69o3z8d 28 19 group group NN cord-303322-d69o3z8d 28 20 trial trial NN cord-303322-d69o3z8d 28 21 in in IN cord-303322-d69o3z8d 28 22 northern northern JJ cord-303322-d69o3z8d 28 23 Australia Australia NNP cord-303322-d69o3z8d 28 24 . . . cord-303322-d69o3z8d 29 1 Indigenous indigenous JJ cord-303322-d69o3z8d 29 2 infants infant NNS cord-303322-d69o3z8d 29 3 ( ( -LRB- cord-303322-d69o3z8d 29 4 aged aged JJ cord-303322-d69o3z8d 29 5 ≤ ≤ NN cord-303322-d69o3z8d 29 6 24-months 24-months CD cord-303322-d69o3z8d 29 7 , , , cord-303322-d69o3z8d 29 8 expected expect VBN cord-303322-d69o3z8d 29 9 number number NN cord-303322-d69o3z8d 29 10 = = SYM cord-303322-d69o3z8d 29 11 200 200 CD cord-303322-d69o3z8d 29 12 ) ) -RRB- cord-303322-d69o3z8d 29 13 admitted admit VBN cord-303322-d69o3z8d 29 14 to to IN cord-303322-d69o3z8d 29 15 one one CD cord-303322-d69o3z8d 29 16 of of IN cord-303322-d69o3z8d 29 17 two two CD cord-303322-d69o3z8d 29 18 regional regional JJ cord-303322-d69o3z8d 29 19 hospitals hospital NNS cord-303322-d69o3z8d 29 20 ( ( -LRB- cord-303322-d69o3z8d 29 21 Darwin Darwin NNP cord-303322-d69o3z8d 29 22 , , , cord-303322-d69o3z8d 29 23 Northern Northern NNP cord-303322-d69o3z8d 29 24 Territory Territory NNP cord-303322-d69o3z8d 29 25 and and CC cord-303322-d69o3z8d 29 26 Townsville Townsville NNP cord-303322-d69o3z8d 29 27 , , , cord-303322-d69o3z8d 29 28 Queensland Queensland NNP cord-303322-d69o3z8d 29 29 ) ) -RRB- cord-303322-d69o3z8d 29 30 with with IN cord-303322-d69o3z8d 29 31 a a DT cord-303322-d69o3z8d 29 32 clinical clinical JJ cord-303322-d69o3z8d 29 33 diagnosis diagnosis NN cord-303322-d69o3z8d 29 34 of of IN cord-303322-d69o3z8d 29 35 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 29 36 and and CC cord-303322-d69o3z8d 29 37 fulfilling fulfil VBG cord-303322-d69o3z8d 29 38 inclusion inclusion NN cord-303322-d69o3z8d 29 39 criteria criterion NNS cord-303322-d69o3z8d 29 40 are be VBP cord-303322-d69o3z8d 29 41 randomised randomised JJ cord-303322-d69o3z8d 29 42 ( ( -LRB- cord-303322-d69o3z8d 29 43 allocation allocation NN cord-303322-d69o3z8d 29 44 concealed conceal VBN cord-303322-d69o3z8d 29 45 ) ) -RRB- cord-303322-d69o3z8d 29 46 to to IN cord-303322-d69o3z8d 29 47 either either CC cord-303322-d69o3z8d 29 48 azithromycin azithromycin NNP cord-303322-d69o3z8d 29 49 ( ( -LRB- cord-303322-d69o3z8d 29 50 30 30 CD cord-303322-d69o3z8d 29 51 mg mg NN cord-303322-d69o3z8d 29 52 / / SYM cord-303322-d69o3z8d 29 53 kg kg NN cord-303322-d69o3z8d 29 54 / / SYM cord-303322-d69o3z8d 29 55 dose dose NN cord-303322-d69o3z8d 29 56 ) ) -RRB- cord-303322-d69o3z8d 29 57 or or CC cord-303322-d69o3z8d 29 58 placebo placebo NN cord-303322-d69o3z8d 30 1 administered administer VBN cord-303322-d69o3z8d 30 2 once once RB cord-303322-d69o3z8d 30 3 weekly weekly RB cord-303322-d69o3z8d 30 4 for for IN cord-303322-d69o3z8d 30 5 three three CD cord-303322-d69o3z8d 30 6 doses dose NNS cord-303322-d69o3z8d 30 7 . . . cord-303322-d69o3z8d 31 1 Clinical clinical JJ cord-303322-d69o3z8d 31 2 data datum NNS cord-303322-d69o3z8d 31 3 are be VBP cord-303322-d69o3z8d 31 4 recorded record VBN cord-303322-d69o3z8d 31 5 twice twice RB cord-303322-d69o3z8d 31 6 daily daily JJ cord-303322-d69o3z8d 31 7 and and CC cord-303322-d69o3z8d 31 8 nasopharyngeal nasopharyngeal JJ cord-303322-d69o3z8d 31 9 swab swab NN cord-303322-d69o3z8d 31 10 are be VBP cord-303322-d69o3z8d 31 11 collected collect VBN cord-303322-d69o3z8d 31 12 at at IN cord-303322-d69o3z8d 31 13 enrolment enrolment NN cord-303322-d69o3z8d 31 14 and and CC cord-303322-d69o3z8d 31 15 at at IN cord-303322-d69o3z8d 31 16 the the DT cord-303322-d69o3z8d 31 17 time time NN cord-303322-d69o3z8d 31 18 of of IN cord-303322-d69o3z8d 31 19 discharge discharge NN cord-303322-d69o3z8d 31 20 from from IN cord-303322-d69o3z8d 31 21 hospital hospital NN cord-303322-d69o3z8d 31 22 . . . cord-303322-d69o3z8d 32 1 Primary primary JJ cord-303322-d69o3z8d 32 2 outcomes outcome NNS cord-303322-d69o3z8d 32 3 are be VBP cord-303322-d69o3z8d 32 4 ' ' `` cord-303322-d69o3z8d 32 5 length length NN cord-303322-d69o3z8d 32 6 of of IN cord-303322-d69o3z8d 32 7 oxygen oxygen NN cord-303322-d69o3z8d 32 8 requirement requirement NN cord-303322-d69o3z8d 32 9 ' ' '' cord-303322-d69o3z8d 32 10 and and CC cord-303322-d69o3z8d 32 11 ' ' '' cord-303322-d69o3z8d 32 12 duration duration NN cord-303322-d69o3z8d 32 13 of of IN cord-303322-d69o3z8d 32 14 stay stay NN cord-303322-d69o3z8d 32 15 , , , cord-303322-d69o3z8d 32 16 ' ' '' cord-303322-d69o3z8d 32 17 the the DT cord-303322-d69o3z8d 32 18 latter latter JJ cord-303322-d69o3z8d 32 19 based base VBN cord-303322-d69o3z8d 32 20 upon upon IN cord-303322-d69o3z8d 32 21 being be VBG cord-303322-d69o3z8d 32 22 judged judge VBN cord-303322-d69o3z8d 32 23 as as IN cord-303322-d69o3z8d 32 24 ' ' `` cord-303322-d69o3z8d 32 25 ready ready JJ cord-303322-d69o3z8d 32 26 for for IN cord-303322-d69o3z8d 32 27 respiratory respiratory JJ cord-303322-d69o3z8d 32 28 discharge discharge NN cord-303322-d69o3z8d 32 29 ' ' '' cord-303322-d69o3z8d 32 30 . . . cord-303322-d69o3z8d 33 1 The the DT cord-303322-d69o3z8d 33 2 main main JJ cord-303322-d69o3z8d 33 3 secondary secondary JJ cord-303322-d69o3z8d 33 4 outcome outcome NN cord-303322-d69o3z8d 33 5 is be VBZ cord-303322-d69o3z8d 33 6 readmission readmission NN cord-303322-d69o3z8d 33 7 for for IN cord-303322-d69o3z8d 33 8 a a DT cord-303322-d69o3z8d 33 9 respiratory respiratory JJ cord-303322-d69o3z8d 33 10 illness illness NN cord-303322-d69o3z8d 33 11 within within IN cord-303322-d69o3z8d 33 12 6-months 6-months CD cord-303322-d69o3z8d 33 13 of of IN cord-303322-d69o3z8d 33 14 leaving leave VBG cord-303322-d69o3z8d 33 15 hospital hospital NN cord-303322-d69o3z8d 33 16 . . . cord-303322-d69o3z8d 34 1 Descriptive descriptive JJ cord-303322-d69o3z8d 34 2 virological virological JJ cord-303322-d69o3z8d 34 3 and and CC cord-303322-d69o3z8d 34 4 bacteriological bacteriological JJ cord-303322-d69o3z8d 34 5 ( ( -LRB- cord-303322-d69o3z8d 34 6 including include VBG cord-303322-d69o3z8d 34 7 development development NN cord-303322-d69o3z8d 34 8 of of IN cord-303322-d69o3z8d 34 9 antibiotic antibiotic JJ cord-303322-d69o3z8d 34 10 resistance resistance NN cord-303322-d69o3z8d 34 11 ) ) -RRB- cord-303322-d69o3z8d 34 12 data datum NNS cord-303322-d69o3z8d 34 13 from from IN cord-303322-d69o3z8d 34 14 nasopharyngeal nasopharyngeal JJ cord-303322-d69o3z8d 34 15 samples sample NNS cord-303322-d69o3z8d 34 16 will will MD cord-303322-d69o3z8d 34 17 also also RB cord-303322-d69o3z8d 34 18 be be VB cord-303322-d69o3z8d 34 19 reported report VBN cord-303322-d69o3z8d 34 20 . . . cord-303322-d69o3z8d 35 1 Discussion discussion NN cord-303322-d69o3z8d 35 2 : : : cord-303322-d69o3z8d 36 1 Two two CD cord-303322-d69o3z8d 36 2 published publish VBN cord-303322-d69o3z8d 36 3 studies study NNS cord-303322-d69o3z8d 36 4 , , , cord-303322-d69o3z8d 36 5 both both DT cord-303322-d69o3z8d 36 6 involving involve VBG cord-303322-d69o3z8d 36 7 different different JJ cord-303322-d69o3z8d 36 8 patient patient JJ cord-303322-d69o3z8d 36 9 populations population NNS cord-303322-d69o3z8d 36 10 and and CC cord-303322-d69o3z8d 36 11 settings setting NNS cord-303322-d69o3z8d 36 12 , , , cord-303322-d69o3z8d 36 13 as as RB cord-303322-d69o3z8d 36 14 well well RB cord-303322-d69o3z8d 36 15 as as IN cord-303322-d69o3z8d 36 16 different different JJ cord-303322-d69o3z8d 36 17 macrolide macrolide NN cord-303322-d69o3z8d 36 18 antibiotics antibiotic NNS cord-303322-d69o3z8d 36 19 and and CC cord-303322-d69o3z8d 36 20 treatment treatment NN cord-303322-d69o3z8d 36 21 duration duration NN cord-303322-d69o3z8d 36 22 , , , cord-303322-d69o3z8d 36 23 have have VBP cord-303322-d69o3z8d 36 24 produced produce VBN cord-303322-d69o3z8d 36 25 conflicting conflicting JJ cord-303322-d69o3z8d 36 26 results result NNS cord-303322-d69o3z8d 36 27 . . . cord-303322-d69o3z8d 37 1 Our -PRON- PRP$ cord-303322-d69o3z8d 37 2 randomised randomised JJ cord-303322-d69o3z8d 37 3 , , , cord-303322-d69o3z8d 37 4 placebocontrolled placebocontrolled JJ cord-303322-d69o3z8d 37 5 trial trial NN cord-303322-d69o3z8d 37 6 of of IN cord-303322-d69o3z8d 37 7 azithromycin azithromycin NNP cord-303322-d69o3z8d 37 8 in in IN cord-303322-d69o3z8d 37 9 Indigenous indigenous JJ cord-303322-d69o3z8d 37 10 infants infant NNS cord-303322-d69o3z8d 37 11 hospitalised hospitalise VBN cord-303322-d69o3z8d 37 12 with with IN cord-303322-d69o3z8d 37 13 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 37 14 is be VBZ cord-303322-d69o3z8d 37 15 designed design VBN cord-303322-d69o3z8d 37 16 to to TO cord-303322-d69o3z8d 37 17 determine determine VB cord-303322-d69o3z8d 37 18 whether whether IN cord-303322-d69o3z8d 37 19 it -PRON- PRP cord-303322-d69o3z8d 37 20 can can MD cord-303322-d69o3z8d 37 21 reduce reduce VB cord-303322-d69o3z8d 37 22 short short JJ cord-303322-d69o3z8d 37 23 - - HYPH cord-303322-d69o3z8d 37 24 term term NN cord-303322-d69o3z8d 37 25 ( ( -LRB- cord-303322-d69o3z8d 37 26 and and CC cord-303322-d69o3z8d 37 27 potentially potentially RB cord-303322-d69o3z8d 37 28 long long JJ cord-303322-d69o3z8d 37 29 - - HYPH cord-303322-d69o3z8d 37 30 term term NN cord-303322-d69o3z8d 37 31 ) ) -RRB- cord-303322-d69o3z8d 37 32 morbidity morbidity NN cord-303322-d69o3z8d 37 33 from from IN cord-303322-d69o3z8d 37 34 respiratory respiratory JJ cord-303322-d69o3z8d 37 35 illness illness NN cord-303322-d69o3z8d 37 36 in in IN cord-303322-d69o3z8d 37 37 Australian australian JJ cord-303322-d69o3z8d 37 38 Indigenous indigenous JJ cord-303322-d69o3z8d 37 39 infants infant NNS cord-303322-d69o3z8d 37 40 who who WP cord-303322-d69o3z8d 37 41 are be VBP cord-303322-d69o3z8d 37 42 at at IN cord-303322-d69o3z8d 37 43 high high JJ cord-303322-d69o3z8d 37 44 risk risk NN cord-303322-d69o3z8d 37 45 of of IN cord-303322-d69o3z8d 37 46 developing develop VBG cord-303322-d69o3z8d 37 47 chronic chronic JJ cord-303322-d69o3z8d 37 48 respiratory respiratory JJ cord-303322-d69o3z8d 37 49 illness illness NN cord-303322-d69o3z8d 37 50 . . . cord-303322-d69o3z8d 38 1 If if IN cord-303322-d69o3z8d 38 2 azithromycin azithromycin NNP cord-303322-d69o3z8d 38 3 is be VBZ cord-303322-d69o3z8d 38 4 efficacious efficacious JJ cord-303322-d69o3z8d 38 5 in in IN cord-303322-d69o3z8d 38 6 reducing reduce VBG cord-303322-d69o3z8d 38 7 the the DT cord-303322-d69o3z8d 38 8 morbidly morbidly JJ cord-303322-d69o3z8d 38 9 of of IN cord-303322-d69o3z8d 38 10 Indigenous indigenous JJ cord-303322-d69o3z8d 38 11 infants infant NNS cord-303322-d69o3z8d 38 12 hospitalised hospitalise VBN cord-303322-d69o3z8d 38 13 with with IN cord-303322-d69o3z8d 38 14 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 38 15 , , , cord-303322-d69o3z8d 38 16 the the DT cord-303322-d69o3z8d 38 17 intervention intervention NN cord-303322-d69o3z8d 38 18 would would MD cord-303322-d69o3z8d 38 19 lead lead VB cord-303322-d69o3z8d 38 20 to to IN cord-303322-d69o3z8d 38 21 improved improve VBN cord-303322-d69o3z8d 38 22 short short JJ cord-303322-d69o3z8d 38 23 term term NN cord-303322-d69o3z8d 38 24 ( ( -LRB- cord-303322-d69o3z8d 38 25 and and CC cord-303322-d69o3z8d 38 26 possibly possibly RB cord-303322-d69o3z8d 38 27 long long JJ cord-303322-d69o3z8d 38 28 term term NN cord-303322-d69o3z8d 38 29 ) ) -RRB- cord-303322-d69o3z8d 38 30 health health NN cord-303322-d69o3z8d 38 31 benefits benefit NNS cord-303322-d69o3z8d 38 32 . . . cord-303322-d69o3z8d 39 1 Trial trial NN cord-303322-d69o3z8d 39 2 registration registration NN cord-303322-d69o3z8d 39 3 : : : cord-303322-d69o3z8d 40 1 Australia Australia NNP cord-303322-d69o3z8d 40 2 and and CC cord-303322-d69o3z8d 40 3 New New NNP cord-303322-d69o3z8d 40 4 Zealand Zealand NNP cord-303322-d69o3z8d 40 5 Clinical Clinical NNP cord-303322-d69o3z8d 40 6 Trials Trials NNPS cord-303322-d69o3z8d 40 7 Register Register NNP cord-303322-d69o3z8d 40 8 ( ( -LRB- cord-303322-d69o3z8d 40 9 ANZCTR ANZCTR NNP cord-303322-d69o3z8d 40 10 ) ) -RRB- cord-303322-d69o3z8d 40 11 : : : cord-303322-d69o3z8d 41 1 ACTRN12610000326099 actrn12610000326099 CD cord-303322-d69o3z8d 42 1 Background Background NNP cord-303322-d69o3z8d 42 2 Worldwide Worldwide NNP cord-303322-d69o3z8d 42 3 , , , cord-303322-d69o3z8d 42 4 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 42 5 is be VBZ cord-303322-d69o3z8d 42 6 the the DT cord-303322-d69o3z8d 42 7 most most RBS cord-303322-d69o3z8d 42 8 common common JJ cord-303322-d69o3z8d 42 9 acute acute JJ cord-303322-d69o3z8d 42 10 lower low JJR cord-303322-d69o3z8d 42 11 respiratory respiratory JJ cord-303322-d69o3z8d 42 12 tract tract NN cord-303322-d69o3z8d 42 13 infection infection NN cord-303322-d69o3z8d 42 14 ( ( -LRB- cord-303322-d69o3z8d 42 15 ALRI ALRI NNP cord-303322-d69o3z8d 42 16 ) ) -RRB- cord-303322-d69o3z8d 42 17 in in IN cord-303322-d69o3z8d 42 18 infants infant NNS cord-303322-d69o3z8d 42 19 [ [ -LRB- cord-303322-d69o3z8d 42 20 1 1 CD cord-303322-d69o3z8d 42 21 ] ] -RRB- cord-303322-d69o3z8d 42 22 [ [ -LRB- cord-303322-d69o3z8d 42 23 2 2 CD cord-303322-d69o3z8d 42 24 ] ] -RRB- cord-303322-d69o3z8d 42 25 [ [ -LRB- cord-303322-d69o3z8d 42 26 3 3 CD cord-303322-d69o3z8d 42 27 ] ] -RRB- cord-303322-d69o3z8d 42 28 . . . cord-303322-d69o3z8d 43 1 In in IN cord-303322-d69o3z8d 43 2 the the DT cord-303322-d69o3z8d 43 3 Northern Northern NNP cord-303322-d69o3z8d 43 4 Territory Territory NNP cord-303322-d69o3z8d 43 5 ( ( -LRB- cord-303322-d69o3z8d 43 6 NT NT NNP cord-303322-d69o3z8d 43 7 , , , cord-303322-d69o3z8d 43 8 Australia Australia NNP cord-303322-d69o3z8d 43 9 ) ) -RRB- cord-303322-d69o3z8d 43 10 , , , cord-303322-d69o3z8d 43 11 ALRIs alri NNS cord-303322-d69o3z8d 43 12 are be VBP cord-303322-d69o3z8d 43 13 the the DT cord-303322-d69o3z8d 43 14 most most RBS cord-303322-d69o3z8d 43 15 frequent frequent JJ cord-303322-d69o3z8d 43 16 reason reason NN cord-303322-d69o3z8d 43 17 for for IN cord-303322-d69o3z8d 43 18 hospitalisation hospitalisation NN cord-303322-d69o3z8d 43 19 of of IN cord-303322-d69o3z8d 43 20 young young JJ cord-303322-d69o3z8d 43 21 children child NNS cord-303322-d69o3z8d 43 22 ( ( -LRB- cord-303322-d69o3z8d 43 23 aged aged JJ cord-303322-d69o3z8d 43 24 < < XX cord-303322-d69o3z8d 43 25 5-years 5-years CD cord-303322-d69o3z8d 43 26 ) ) -RRB- cord-303322-d69o3z8d 43 27 . . . cord-303322-d69o3z8d 44 1 ALRIs alri NNS cord-303322-d69o3z8d 44 2 are be VBP cord-303322-d69o3z8d 44 3 also also RB cord-303322-d69o3z8d 44 4 the the DT cord-303322-d69o3z8d 44 5 commonest common JJS cord-303322-d69o3z8d 44 6 cause cause NN cord-303322-d69o3z8d 44 7 of of IN cord-303322-d69o3z8d 44 8 preventable preventable JJ cord-303322-d69o3z8d 44 9 deaths death NNS cord-303322-d69o3z8d 44 10 in in IN cord-303322-d69o3z8d 44 11 Indigenous indigenous JJ cord-303322-d69o3z8d 44 12 infants infant NNS cord-303322-d69o3z8d 44 13 ( ( -LRB- cord-303322-d69o3z8d 44 14 5 5 CD cord-303322-d69o3z8d 44 15 times time NNS cord-303322-d69o3z8d 44 16 that that DT cord-303322-d69o3z8d 44 17 of of IN cord-303322-d69o3z8d 44 18 non non JJ cord-303322-d69o3z8d 44 19 - - JJ cord-303322-d69o3z8d 44 20 Indigenous indigenous JJ cord-303322-d69o3z8d 44 21 ) ) -RRB- cord-303322-d69o3z8d 44 22 [ [ -LRB- cord-303322-d69o3z8d 44 23 4 4 CD cord-303322-d69o3z8d 44 24 ] ] -RRB- cord-303322-d69o3z8d 44 25 . . . cord-303322-d69o3z8d 45 1 Of of IN cord-303322-d69o3z8d 45 2 ALRIs alri NNS cord-303322-d69o3z8d 45 3 , , , cord-303322-d69o3z8d 45 4 bronchiolitis bronchiolitis NNP cord-303322-d69o3z8d 45 5 ( ( -LRB- cord-303322-d69o3z8d 45 6 with with IN cord-303322-d69o3z8d 45 7 or or CC cord-303322-d69o3z8d 45 8 without without IN cord-303322-d69o3z8d 45 9 pneumonia pneumonia NN cord-303322-d69o3z8d 45 10 ) ) -RRB- cord-303322-d69o3z8d 45 11 is be VBZ cord-303322-d69o3z8d 45 12 the the DT cord-303322-d69o3z8d 45 13 most most RBS cord-303322-d69o3z8d 45 14 frequent frequent JJ cord-303322-d69o3z8d 45 15 reason reason NN cord-303322-d69o3z8d 45 16 for for IN cord-303322-d69o3z8d 45 17 hospital hospital NN cord-303322-d69o3z8d 45 18 admission admission NN cord-303322-d69o3z8d 45 19 in in IN cord-303322-d69o3z8d 45 20 NT NT NNP cord-303322-d69o3z8d 45 21 Indigenous indigenous JJ cord-303322-d69o3z8d 45 22 infants infant NNS cord-303322-d69o3z8d 45 23 aged age VBN cord-303322-d69o3z8d 45 24 under under IN cord-303322-d69o3z8d 45 25 12-months 12-months CD cord-303322-d69o3z8d 45 26 [ [ -LRB- cord-303322-d69o3z8d 45 27 5 5 CD cord-303322-d69o3z8d 45 28 ] ] -RRB- cord-303322-d69o3z8d 45 29 . . . cord-303322-d69o3z8d 46 1 Despite despite IN cord-303322-d69o3z8d 46 2 this this DT cord-303322-d69o3z8d 46 3 heavy heavy JJ cord-303322-d69o3z8d 46 4 burden burden NN cord-303322-d69o3z8d 46 5 of of IN cord-303322-d69o3z8d 46 6 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 46 7 in in IN cord-303322-d69o3z8d 46 8 Indigenous indigenous JJ cord-303322-d69o3z8d 46 9 infants infant NNS cord-303322-d69o3z8d 46 10 , , , cord-303322-d69o3z8d 46 11 currently currently RB cord-303322-d69o3z8d 46 12 no no DT cord-303322-d69o3z8d 46 13 prospective prospective JJ cord-303322-d69o3z8d 46 14 studies study NNS cord-303322-d69o3z8d 46 15 have have VBP cord-303322-d69o3z8d 46 16 been be VBN cord-303322-d69o3z8d 46 17 published publish VBN cord-303322-d69o3z8d 46 18 . . . cord-303322-d69o3z8d 47 1 Our -PRON- PRP$ cord-303322-d69o3z8d 47 2 retrospective retrospective JJ cord-303322-d69o3z8d 47 3 review review NN cord-303322-d69o3z8d 47 4 of of IN cord-303322-d69o3z8d 47 5 101 101 CD cord-303322-d69o3z8d 47 6 infants infant NNS cord-303322-d69o3z8d 47 7 hospitalised hospitalise VBN cord-303322-d69o3z8d 47 8 with with IN cord-303322-d69o3z8d 47 9 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 47 10 at at IN cord-303322-d69o3z8d 47 11 the the DT cord-303322-d69o3z8d 47 12 Royal Royal NNP cord-303322-d69o3z8d 47 13 Darwin Darwin NNP cord-303322-d69o3z8d 47 14 Hospital Hospital NNP cord-303322-d69o3z8d 47 15 ( ( -LRB- cord-303322-d69o3z8d 47 16 Darwin Darwin NNP cord-303322-d69o3z8d 47 17 , , , cord-303322-d69o3z8d 47 18 Northern Northern NNP cord-303322-d69o3z8d 47 19 Territory Territory NNP cord-303322-d69o3z8d 47 20 ) ) -RRB- cord-303322-d69o3z8d 47 21 found find VBD cord-303322-d69o3z8d 47 22 that that IN cord-303322-d69o3z8d 47 23 33.7 33.7 CD cord-303322-d69o3z8d 47 24 % % NN cord-303322-d69o3z8d 47 25 of of IN cord-303322-d69o3z8d 47 26 Indigenous indigenous JJ cord-303322-d69o3z8d 47 27 infants infant NNS cord-303322-d69o3z8d 47 28 were be VBD cord-303322-d69o3z8d 47 29 readmitted readmitte VBN cord-303322-d69o3z8d 47 30 within within IN cord-303322-d69o3z8d 47 31 six six CD cord-303322-d69o3z8d 47 32 - - HYPH cord-303322-d69o3z8d 47 33 months month NNS cord-303322-d69o3z8d 47 34 of of IN cord-303322-d69o3z8d 47 35 discharge discharge NN cord-303322-d69o3z8d 47 36 from from IN cord-303322-d69o3z8d 47 37 hospital hospital NN cord-303322-d69o3z8d 47 38 [ [ -LRB- cord-303322-d69o3z8d 47 39 6 6 CD cord-303322-d69o3z8d 47 40 ] ] -RRB- cord-303322-d69o3z8d 47 41 . . . cord-303322-d69o3z8d 48 1 As as IN cord-303322-d69o3z8d 48 2 most most JJS cord-303322-d69o3z8d 48 3 were be VBD cord-303322-d69o3z8d 48 4 retrieved retrieve VBN cord-303322-d69o3z8d 48 5 from from IN cord-303322-d69o3z8d 48 6 remote remote JJ cord-303322-d69o3z8d 48 7 communities community NNS cord-303322-d69o3z8d 48 8 , , , cord-303322-d69o3z8d 48 9 the the DT cord-303322-d69o3z8d 48 10 impact impact NN cord-303322-d69o3z8d 48 11 of of IN cord-303322-d69o3z8d 48 12 the the DT cord-303322-d69o3z8d 48 13 illness illness NN cord-303322-d69o3z8d 48 14 , , , cord-303322-d69o3z8d 48 15 its -PRON- PRP$ cord-303322-d69o3z8d 48 16 costs cost NNS cord-303322-d69o3z8d 48 17 and and CC cord-303322-d69o3z8d 48 18 social social JJ cord-303322-d69o3z8d 48 19 dislocation dislocation NN cord-303322-d69o3z8d 48 20 were be VBD cord-303322-d69o3z8d 48 21 likely likely JJ cord-303322-d69o3z8d 48 22 to to TO cord-303322-d69o3z8d 48 23 have have VB cord-303322-d69o3z8d 48 24 been be VBN cord-303322-d69o3z8d 48 25 substantial substantial JJ cord-303322-d69o3z8d 48 26 . . . cord-303322-d69o3z8d 49 1 Recurrent recurrent JJ cord-303322-d69o3z8d 49 2 ALRIs alri NNS cord-303322-d69o3z8d 49 3 are be VBP cord-303322-d69o3z8d 49 4 independently independently RB cord-303322-d69o3z8d 49 5 associated associate VBN cord-303322-d69o3z8d 49 6 with with IN cord-303322-d69o3z8d 49 7 the the DT cord-303322-d69o3z8d 49 8 development development NN cord-303322-d69o3z8d 49 9 of of IN cord-303322-d69o3z8d 49 10 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 49 11 [ [ -LRB- cord-303322-d69o3z8d 49 12 7 7 CD cord-303322-d69o3z8d 49 13 ] ] -RRB- cord-303322-d69o3z8d 49 14 and and CC cord-303322-d69o3z8d 49 15 reduced reduce VBN cord-303322-d69o3z8d 49 16 pulmonary pulmonary JJ cord-303322-d69o3z8d 49 17 function function NN cord-303322-d69o3z8d 49 18 later later RB cord-303322-d69o3z8d 49 19 in in IN cord-303322-d69o3z8d 49 20 life life NN cord-303322-d69o3z8d 49 21 [ [ -LRB- cord-303322-d69o3z8d 49 22 8 8 CD cord-303322-d69o3z8d 49 23 ] ] -RRB- cord-303322-d69o3z8d 49 24 . . . cord-303322-d69o3z8d 50 1 Low low JJ cord-303322-d69o3z8d 50 2 birth birth NN cord-303322-d69o3z8d 50 3 weight weight NN cord-303322-d69o3z8d 50 4 and and CC cord-303322-d69o3z8d 50 5 pre pre JJ cord-303322-d69o3z8d 50 6 - - JJ cord-303322-d69o3z8d 50 7 existing existing JJ cord-303322-d69o3z8d 50 8 small small JJ cord-303322-d69o3z8d 50 9 lungs lung NNS cord-303322-d69o3z8d 50 10 are be VBP cord-303322-d69o3z8d 50 11 important important JJ cord-303322-d69o3z8d 50 12 determinants determinant NNS cord-303322-d69o3z8d 50 13 of of IN cord-303322-d69o3z8d 50 14 future future JJ cord-303322-d69o3z8d 50 15 lung lung NN cord-303322-d69o3z8d 50 16 function function NN cord-303322-d69o3z8d 50 17 , , , cord-303322-d69o3z8d 50 18 but but CC cord-303322-d69o3z8d 50 19 there there EX cord-303322-d69o3z8d 50 20 is be VBZ cord-303322-d69o3z8d 50 21 increasing increase VBG cord-303322-d69o3z8d 50 22 evidence evidence NN cord-303322-d69o3z8d 50 23 that that IN cord-303322-d69o3z8d 50 24 events event NNS cord-303322-d69o3z8d 50 25 in in IN cord-303322-d69o3z8d 50 26 early early JJ cord-303322-d69o3z8d 50 27 life life NN cord-303322-d69o3z8d 50 28 are be VBP cord-303322-d69o3z8d 50 29 at at IN cord-303322-d69o3z8d 50 30 least least JJS cord-303322-d69o3z8d 50 31 equally equally RB cord-303322-d69o3z8d 50 32 important important JJ cord-303322-d69o3z8d 50 33 determinants determinant NNS cord-303322-d69o3z8d 50 34 of of IN cord-303322-d69o3z8d 50 35 adult adult JJ cord-303322-d69o3z8d 50 36 pulmonary pulmonary JJ cord-303322-d69o3z8d 50 37 dysfunction dysfunction NN cord-303322-d69o3z8d 50 38 [ [ -LRB- cord-303322-d69o3z8d 50 39 8 8 CD cord-303322-d69o3z8d 50 40 ] ] -RRB- cord-303322-d69o3z8d 50 41 [ [ -LRB- cord-303322-d69o3z8d 50 42 9 9 CD cord-303322-d69o3z8d 50 43 ] ] -RRB- cord-303322-d69o3z8d 50 44 [ [ -LRB- cord-303322-d69o3z8d 50 45 10 10 CD cord-303322-d69o3z8d 50 46 ] ] -RRB- cord-303322-d69o3z8d 50 47 . . . cord-303322-d69o3z8d 51 1 The the DT cord-303322-d69o3z8d 51 2 first first JJ cord-303322-d69o3z8d 51 3 few few JJ cord-303322-d69o3z8d 51 4 years year NNS cord-303322-d69o3z8d 51 5 of of IN cord-303322-d69o3z8d 51 6 life life NN cord-303322-d69o3z8d 51 7 are be VBP cord-303322-d69o3z8d 51 8 the the DT cord-303322-d69o3z8d 51 9 most most RBS cord-303322-d69o3z8d 51 10 critical critical JJ cord-303322-d69o3z8d 51 11 period period NN cord-303322-d69o3z8d 51 12 [ [ -LRB- cord-303322-d69o3z8d 51 13 11 11 CD cord-303322-d69o3z8d 51 14 ] ] -RRB- cord-303322-d69o3z8d 51 15 . . . cord-303322-d69o3z8d 52 1 Thus thus RB cord-303322-d69o3z8d 52 2 events event NNS cord-303322-d69o3z8d 52 3 such such JJ cord-303322-d69o3z8d 52 4 as as IN cord-303322-d69o3z8d 52 5 severe severe JJ cord-303322-d69o3z8d 52 6 ALRIs alri NNS cord-303322-d69o3z8d 52 7 during during IN cord-303322-d69o3z8d 52 8 this this DT cord-303322-d69o3z8d 52 9 critical critical JJ cord-303322-d69o3z8d 52 10 period period NN cord-303322-d69o3z8d 52 11 are be VBP cord-303322-d69o3z8d 52 12 likely likely JJ cord-303322-d69o3z8d 52 13 to to TO cord-303322-d69o3z8d 52 14 have have VB cord-303322-d69o3z8d 52 15 long long JJ cord-303322-d69o3z8d 52 16 term term NN cord-303322-d69o3z8d 52 17 effects effect NNS cord-303322-d69o3z8d 52 18 . . . cord-303322-d69o3z8d 53 1 Australia Australia NNP cord-303322-d69o3z8d 53 2 - - HYPH cord-303322-d69o3z8d 53 3 wide wide RB cord-303322-d69o3z8d 53 4 , , , cord-303322-d69o3z8d 53 5 hospitalisation hospitalisation NN cord-303322-d69o3z8d 53 6 rates rate NNS cord-303322-d69o3z8d 53 7 of of IN cord-303322-d69o3z8d 53 8 respiratory respiratory JJ cord-303322-d69o3z8d 53 9 disorders disorder NNS cord-303322-d69o3z8d 53 10 among among IN cord-303322-d69o3z8d 53 11 Indigenous Indigenous NNP cord-303322-d69o3z8d 53 12 Australians Australians NNPS cord-303322-d69o3z8d 53 13 are be VBP cord-303322-d69o3z8d 53 14 second second JJ cord-303322-d69o3z8d 53 15 only only RB cord-303322-d69o3z8d 53 16 to to IN cord-303322-d69o3z8d 53 17 those those DT cord-303322-d69o3z8d 53 18 for for IN cord-303322-d69o3z8d 53 19 renal renal JJ cord-303322-d69o3z8d 53 20 dialysis dialysis NN cord-303322-d69o3z8d 53 21 [ [ -LRB- cord-303322-d69o3z8d 53 22 12 12 CD cord-303322-d69o3z8d 53 23 ] ] -RRB- cord-303322-d69o3z8d 53 24 . . . cord-303322-d69o3z8d 54 1 Furthermore furthermore RB cord-303322-d69o3z8d 54 2 , , , cord-303322-d69o3z8d 54 3 we -PRON- PRP cord-303322-d69o3z8d 54 4 have have VBP cord-303322-d69o3z8d 54 5 previously previously RB cord-303322-d69o3z8d 54 6 documented document VBN cord-303322-d69o3z8d 54 7 that that IN cord-303322-d69o3z8d 54 8 the the DT cord-303322-d69o3z8d 54 9 severity severity NN cord-303322-d69o3z8d 54 10 of of IN cord-303322-d69o3z8d 54 11 the the DT cord-303322-d69o3z8d 54 12 hospitalised hospitalise VBN cord-303322-d69o3z8d 54 13 ALRI ALRI NNP cord-303322-d69o3z8d 54 14 episode episode NN cord-303322-d69o3z8d 54 15 , , , cord-303322-d69o3z8d 54 16 as as IN cord-303322-d69o3z8d 54 17 determined determine VBN cord-303322-d69o3z8d 54 18 by by IN cord-303322-d69o3z8d 54 19 oxygen oxygen NN cord-303322-d69o3z8d 54 20 requirement requirement NN cord-303322-d69o3z8d 54 21 and and CC cord-303322-d69o3z8d 54 22 duration duration NN cord-303322-d69o3z8d 54 23 of of IN cord-303322-d69o3z8d 54 24 hospitalisation hospitalisation NN cord-303322-d69o3z8d 54 25 , , , cord-303322-d69o3z8d 54 26 was be VBD cord-303322-d69o3z8d 54 27 an an DT cord-303322-d69o3z8d 54 28 independent independent JJ cord-303322-d69o3z8d 54 29 risk risk NN cord-303322-d69o3z8d 54 30 factor factor NN cord-303322-d69o3z8d 54 31 for for IN cord-303322-d69o3z8d 54 32 subsequent subsequent JJ cord-303322-d69o3z8d 54 33 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 54 34 [ [ -LRB- cord-303322-d69o3z8d 54 35 7 7 CD cord-303322-d69o3z8d 54 36 ] ] -RRB- cord-303322-d69o3z8d 54 37 . . . cord-303322-d69o3z8d 55 1 In in IN cord-303322-d69o3z8d 55 2 the the DT cord-303322-d69o3z8d 55 3 Northern Northern NNP cord-303322-d69o3z8d 55 4 Territory Territory NNP cord-303322-d69o3z8d 55 5 ( ( -LRB- cord-303322-d69o3z8d 55 6 NT NT NNP cord-303322-d69o3z8d 55 7 ) ) -RRB- cord-303322-d69o3z8d 55 8 , , , cord-303322-d69o3z8d 55 9 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 55 10 affects affect VBZ cord-303322-d69o3z8d 55 11 one one CD cord-303322-d69o3z8d 55 12 in in IN cord-303322-d69o3z8d 55 13 every every DT cord-303322-d69o3z8d 55 14 68 68 CD cord-303322-d69o3z8d 55 15 Indigenous indigenous JJ cord-303322-d69o3z8d 55 16 children child NNS cord-303322-d69o3z8d 55 17 , , , cord-303322-d69o3z8d 55 18 far far RB cord-303322-d69o3z8d 55 19 exceeding exceed VBG cord-303322-d69o3z8d 55 20 that that DT cord-303322-d69o3z8d 55 21 of of IN cord-303322-d69o3z8d 55 22 cystic cystic JJ cord-303322-d69o3z8d 55 23 fibrosis fibrosis NN cord-303322-d69o3z8d 55 24 ( ( -LRB- cord-303322-d69o3z8d 55 25 CF CF NNP cord-303322-d69o3z8d 55 26 ) ) -RRB- cord-303322-d69o3z8d 55 27 in in IN cord-303322-d69o3z8d 55 28 non non JJ cord-303322-d69o3z8d 55 29 - - JJ cord-303322-d69o3z8d 55 30 Indigenous indigenous JJ cord-303322-d69o3z8d 55 31 Australian australian JJ cord-303322-d69o3z8d 55 32 children child NNS cord-303322-d69o3z8d 55 33 ( ( -LRB- cord-303322-d69o3z8d 55 34 1 1 CD cord-303322-d69o3z8d 55 35 in in IN cord-303322-d69o3z8d 55 36 2857 2857 CD cord-303322-d69o3z8d 55 37 ) ) -RRB- cord-303322-d69o3z8d 55 38 [ [ -LRB- cord-303322-d69o3z8d 55 39 13 13 CD cord-303322-d69o3z8d 55 40 , , , cord-303322-d69o3z8d 55 41 14 14 CD cord-303322-d69o3z8d 55 42 ] ] -RRB- cord-303322-d69o3z8d 55 43 . . . cord-303322-d69o3z8d 56 1 Thus thus RB cord-303322-d69o3z8d 56 2 , , , cord-303322-d69o3z8d 56 3 any any DT cord-303322-d69o3z8d 56 4 intervention intervention NN cord-303322-d69o3z8d 56 5 that that WDT cord-303322-d69o3z8d 56 6 reduces reduce VBZ cord-303322-d69o3z8d 56 7 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 56 8 severity severity NN cord-303322-d69o3z8d 56 9 and/or and/or CC cord-303322-d69o3z8d 56 10 risk risk NN cord-303322-d69o3z8d 56 11 of of IN cord-303322-d69o3z8d 56 12 readmission readmission NN cord-303322-d69o3z8d 56 13 for for IN cord-303322-d69o3z8d 56 14 respiratory respiratory JJ cord-303322-d69o3z8d 56 15 illness illness NN cord-303322-d69o3z8d 56 16 in in IN cord-303322-d69o3z8d 56 17 Indigenous indigenous JJ cord-303322-d69o3z8d 56 18 infants infant NNS cord-303322-d69o3z8d 56 19 may may MD cord-303322-d69o3z8d 56 20 have have VB cord-303322-d69o3z8d 56 21 both both DT cord-303322-d69o3z8d 56 22 short short JJ cord-303322-d69o3z8d 56 23 term term NN cord-303322-d69o3z8d 56 24 and and CC cord-303322-d69o3z8d 56 25 potential potential JJ cord-303322-d69o3z8d 56 26 long long JJ cord-303322-d69o3z8d 56 27 term term NN cord-303322-d69o3z8d 56 28 benefits benefit NNS cord-303322-d69o3z8d 56 29 in in IN cord-303322-d69o3z8d 56 30 our -PRON- PRP$ cord-303322-d69o3z8d 56 31 setting setting NN cord-303322-d69o3z8d 56 32 . . . cord-303322-d69o3z8d 57 1 Bronchiolitis Bronchiolitis NNP cord-303322-d69o3z8d 57 2 is be VBZ cord-303322-d69o3z8d 57 3 characterised characterise VBN cord-303322-d69o3z8d 57 4 by by IN cord-303322-d69o3z8d 57 5 extensive extensive JJ cord-303322-d69o3z8d 57 6 inflammation inflammation NN cord-303322-d69o3z8d 57 7 of of IN cord-303322-d69o3z8d 57 8 the the DT cord-303322-d69o3z8d 57 9 airways airway NNS cord-303322-d69o3z8d 57 10 accompanied accompany VBN cord-303322-d69o3z8d 57 11 by by IN cord-303322-d69o3z8d 57 12 increased increase VBN cord-303322-d69o3z8d 57 13 mucous mucous JJ cord-303322-d69o3z8d 57 14 production production NN cord-303322-d69o3z8d 57 15 and and CC cord-303322-d69o3z8d 57 16 necrosis necrosis NN cord-303322-d69o3z8d 57 17 of of IN cord-303322-d69o3z8d 57 18 airway airway NN cord-303322-d69o3z8d 57 19 epithelial epithelial JJ cord-303322-d69o3z8d 57 20 cells cell NNS cord-303322-d69o3z8d 57 21 . . . cord-303322-d69o3z8d 58 1 In in IN cord-303322-d69o3z8d 58 2 paediatrics paediatric NNS cord-303322-d69o3z8d 58 3 , , , cord-303322-d69o3z8d 58 4 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 58 5 is be VBZ cord-303322-d69o3z8d 58 6 a a DT cord-303322-d69o3z8d 58 7 clinical clinical JJ cord-303322-d69o3z8d 58 8 diagnosis diagnosis NN cord-303322-d69o3z8d 58 9 characterised characterise VBN cord-303322-d69o3z8d 58 10 by by IN cord-303322-d69o3z8d 58 11 tachypnoea tachypnoea NNS cord-303322-d69o3z8d 58 12 , , , cord-303322-d69o3z8d 58 13 wheeze wheeze NN cord-303322-d69o3z8d 58 14 and/or and/or CC cord-303322-d69o3z8d 58 15 crepitations crepitation NNS cord-303322-d69o3z8d 58 16 in in IN cord-303322-d69o3z8d 58 17 infants infant NNS cord-303322-d69o3z8d 58 18 following follow VBG cord-303322-d69o3z8d 58 19 a a DT cord-303322-d69o3z8d 58 20 preceding precede VBG cord-303322-d69o3z8d 58 21 upper upper JJ cord-303322-d69o3z8d 58 22 respiratory respiratory JJ cord-303322-d69o3z8d 58 23 illness illness NN cord-303322-d69o3z8d 58 24 [ [ -LRB- cord-303322-d69o3z8d 58 25 1 1 CD cord-303322-d69o3z8d 58 26 ] ] -RRB- cord-303322-d69o3z8d 58 27 . . . cord-303322-d69o3z8d 59 1 It -PRON- PRP cord-303322-d69o3z8d 59 2 is be VBZ cord-303322-d69o3z8d 59 3 primarily primarily RB cord-303322-d69o3z8d 59 4 caused cause VBN cord-303322-d69o3z8d 59 5 by by IN cord-303322-d69o3z8d 59 6 infection infection NN cord-303322-d69o3z8d 59 7 of of IN cord-303322-d69o3z8d 59 8 the the DT cord-303322-d69o3z8d 59 9 respiratory respiratory JJ cord-303322-d69o3z8d 59 10 epithelial epithelial JJ cord-303322-d69o3z8d 59 11 cells cell NNS cord-303322-d69o3z8d 59 12 by by IN cord-303322-d69o3z8d 59 13 a a DT cord-303322-d69o3z8d 59 14 variety variety NN cord-303322-d69o3z8d 59 15 of of IN cord-303322-d69o3z8d 59 16 viruses virus NNS cord-303322-d69o3z8d 59 17 , , , cord-303322-d69o3z8d 59 18 especially especially RB cord-303322-d69o3z8d 59 19 respiratory respiratory JJ cord-303322-d69o3z8d 59 20 syncytial syncytial JJ cord-303322-d69o3z8d 59 21 virus virus NN cord-303322-d69o3z8d 59 22 ( ( -LRB- cord-303322-d69o3z8d 59 23 RSV RSV NNP cord-303322-d69o3z8d 59 24 ) ) -RRB- cord-303322-d69o3z8d 59 25 . . . cord-303322-d69o3z8d 60 1 Other other JJ cord-303322-d69o3z8d 60 2 viruses virus NNS cord-303322-d69o3z8d 60 3 ( ( -LRB- cord-303322-d69o3z8d 60 4 adenovirus adenovirus NN cord-303322-d69o3z8d 60 5 , , , cord-303322-d69o3z8d 60 6 influenza influenza NN cord-303322-d69o3z8d 60 7 , , , cord-303322-d69o3z8d 60 8 parainfluenza parainfluenza NNP cord-303322-d69o3z8d 60 9 , , , cord-303322-d69o3z8d 60 10 human human NNP cord-303322-d69o3z8d 60 11 metapneumovirus metapneumovirus NNP cord-303322-d69o3z8d 60 12 , , , cord-303322-d69o3z8d 60 13 rhinovirus rhinovirus NN cord-303322-d69o3z8d 60 14 ) ) -RRB- cord-303322-d69o3z8d 60 15 are be VBP cord-303322-d69o3z8d 60 16 also also RB cord-303322-d69o3z8d 60 17 implicated implicate VBN cord-303322-d69o3z8d 60 18 and and CC cord-303322-d69o3z8d 60 19 increasingly increasingly RB cord-303322-d69o3z8d 60 20 new new JJ cord-303322-d69o3z8d 60 21 viruses virus NNS cord-303322-d69o3z8d 60 22 are be VBP cord-303322-d69o3z8d 60 23 being be VBG cord-303322-d69o3z8d 60 24 detected detect VBN cord-303322-d69o3z8d 60 25 in in IN cord-303322-d69o3z8d 60 26 association association NN cord-303322-d69o3z8d 60 27 with with IN cord-303322-d69o3z8d 60 28 this this DT cord-303322-d69o3z8d 60 29 illness illness NN cord-303322-d69o3z8d 60 30 [ [ -LRB- cord-303322-d69o3z8d 60 31 15 15 CD cord-303322-d69o3z8d 60 32 ] ] -RRB- cord-303322-d69o3z8d 60 33 . . . cord-303322-d69o3z8d 61 1 In in IN cord-303322-d69o3z8d 61 2 addition addition NN cord-303322-d69o3z8d 61 3 , , , cord-303322-d69o3z8d 61 4 Mycoplasma mycoplasma NN cord-303322-d69o3z8d 61 5 pneumoniae pneumoniae NN cord-303322-d69o3z8d 61 6 and and CC cord-303322-d69o3z8d 61 7 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 61 8 species specie NNS cord-303322-d69o3z8d 61 9 are be VBP cord-303322-d69o3z8d 61 10 recognised recognise VBN cord-303322-d69o3z8d 61 11 increasingly increasingly RB cord-303322-d69o3z8d 61 12 as as IN cord-303322-d69o3z8d 61 13 important important JJ cord-303322-d69o3z8d 61 14 contributors contributor NNS cord-303322-d69o3z8d 61 15 to to IN cord-303322-d69o3z8d 61 16 the the DT cord-303322-d69o3z8d 61 17 development development NN cord-303322-d69o3z8d 61 18 of of IN cord-303322-d69o3z8d 61 19 chronic chronic JJ cord-303322-d69o3z8d 61 20 lung lung NN cord-303322-d69o3z8d 61 21 disease disease NN cord-303322-d69o3z8d 61 22 and and CC cord-303322-d69o3z8d 61 23 altered altered JJ cord-303322-d69o3z8d 61 24 lung lung NN cord-303322-d69o3z8d 61 25 maturation maturation NN cord-303322-d69o3z8d 61 26 [ [ -LRB- cord-303322-d69o3z8d 61 27 16 16 CD cord-303322-d69o3z8d 61 28 ] ] -RRB- cord-303322-d69o3z8d 61 29 [ [ -LRB- cord-303322-d69o3z8d 61 30 17 17 CD cord-303322-d69o3z8d 61 31 ] ] -RRB- cord-303322-d69o3z8d 61 32 [ [ -LRB- cord-303322-d69o3z8d 61 33 18 18 CD cord-303322-d69o3z8d 61 34 ] ] -RRB- cord-303322-d69o3z8d 61 35 [ [ -LRB- cord-303322-d69o3z8d 61 36 19 19 CD cord-303322-d69o3z8d 61 37 ] ] -RRB- cord-303322-d69o3z8d 61 38 . . . cord-303322-d69o3z8d 62 1 New new JJ cord-303322-d69o3z8d 62 2 treatable treatable JJ cord-303322-d69o3z8d 62 3 bacteria bacteria NNS cord-303322-d69o3z8d 62 4 such such JJ cord-303322-d69o3z8d 62 5 as as IN cord-303322-d69o3z8d 62 6 Simkania Simkania NNP cord-303322-d69o3z8d 62 7 negevensis negevensis NNP cord-303322-d69o3z8d 62 8 ( ( -LRB- cord-303322-d69o3z8d 62 9 a a DT cord-303322-d69o3z8d 62 10 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 62 11 - - HYPH cord-303322-d69o3z8d 62 12 like like JJ cord-303322-d69o3z8d 62 13 microbe microbe NN cord-303322-d69o3z8d 62 14 ) ) -RRB- cord-303322-d69o3z8d 62 15 has have VBZ cord-303322-d69o3z8d 62 16 been be VBN cord-303322-d69o3z8d 62 17 found find VBN cord-303322-d69o3z8d 62 18 in in IN cord-303322-d69o3z8d 62 19 Canadian canadian JJ cord-303322-d69o3z8d 62 20 Inuit inuit JJ cord-303322-d69o3z8d 62 21 infants infant NNS cord-303322-d69o3z8d 62 22 with with IN cord-303322-d69o3z8d 62 23 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 62 24 [ [ -LRB- cord-303322-d69o3z8d 62 25 20 20 CD cord-303322-d69o3z8d 62 26 ] ] -RRB- cord-303322-d69o3z8d 62 27 . . . cord-303322-d69o3z8d 63 1 There there EX cord-303322-d69o3z8d 63 2 are be VBP cord-303322-d69o3z8d 63 3 no no DT cord-303322-d69o3z8d 63 4 published publish VBN cord-303322-d69o3z8d 63 5 data datum NNS cord-303322-d69o3z8d 63 6 on on IN cord-303322-d69o3z8d 63 7 the the DT cord-303322-d69o3z8d 63 8 nature nature NN cord-303322-d69o3z8d 63 9 or or CC cord-303322-d69o3z8d 63 10 diversity diversity NN cord-303322-d69o3z8d 63 11 of of IN cord-303322-d69o3z8d 63 12 respiratory respiratory JJ cord-303322-d69o3z8d 63 13 pathogens pathogen NNS cord-303322-d69o3z8d 63 14 associated associate VBN cord-303322-d69o3z8d 63 15 with with IN cord-303322-d69o3z8d 63 16 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 63 17 in in IN cord-303322-d69o3z8d 63 18 Indigenous indigenous JJ cord-303322-d69o3z8d 63 19 Australians Australians NNPS cord-303322-d69o3z8d 63 20 infants infant NNS cord-303322-d69o3z8d 63 21 . . . cord-303322-d69o3z8d 64 1 Typically typically RB cord-303322-d69o3z8d 64 2 anti anti NNS cord-303322-d69o3z8d 64 3 - - NNS cord-303322-d69o3z8d 64 4 microbials microbial NNS cord-303322-d69o3z8d 64 5 are be VBP cord-303322-d69o3z8d 64 6 not not RB cord-303322-d69o3z8d 64 7 recommended recommend VBN cord-303322-d69o3z8d 64 8 in in IN cord-303322-d69o3z8d 64 9 the the DT cord-303322-d69o3z8d 64 10 routine routine JJ cord-303322-d69o3z8d 64 11 management management NN cord-303322-d69o3z8d 64 12 of of IN cord-303322-d69o3z8d 64 13 bronchiolitis bronchiolitis NNP cord-303322-d69o3z8d 64 14 [ [ -LRB- cord-303322-d69o3z8d 64 15 1 1 CD cord-303322-d69o3z8d 64 16 , , , cord-303322-d69o3z8d 64 17 21 21 CD cord-303322-d69o3z8d 64 18 ] ] -RRB- cord-303322-d69o3z8d 64 19 . . . cord-303322-d69o3z8d 65 1 While while IN cord-303322-d69o3z8d 65 2 there there EX cord-303322-d69o3z8d 65 3 are be VBP cord-303322-d69o3z8d 65 4 two two CD cord-303322-d69o3z8d 65 5 RCTs RCTs NNPS cord-303322-d69o3z8d 65 6 on on IN cord-303322-d69o3z8d 65 7 macrolides macrolide NNS cord-303322-d69o3z8d 65 8 for for IN cord-303322-d69o3z8d 65 9 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 65 10 , , , cord-303322-d69o3z8d 65 11 the the DT cord-303322-d69o3z8d 65 12 single single JJ cord-303322-d69o3z8d 65 13 available available JJ cord-303322-d69o3z8d 65 14 RCT RCT NNP cord-303322-d69o3z8d 65 15 on on IN cord-303322-d69o3z8d 65 16 a a DT cord-303322-d69o3z8d 65 17 non non JJ cord-303322-d69o3z8d 65 18 - - JJ cord-303322-d69o3z8d 65 19 macrolide macrolide JJ cord-303322-d69o3z8d 65 20 anti anti JJ cord-303322-d69o3z8d 65 21 - - JJ cord-303322-d69o3z8d 65 22 microbial microbial JJ cord-303322-d69o3z8d 65 23 was be VBD cord-303322-d69o3z8d 65 24 a a DT cord-303322-d69o3z8d 65 25 negative negative JJ cord-303322-d69o3z8d 65 26 study study NN cord-303322-d69o3z8d 65 27 [ [ -LRB- cord-303322-d69o3z8d 65 28 22 22 CD cord-303322-d69o3z8d 65 29 ] ] -RRB- cord-303322-d69o3z8d 65 30 . . . cord-303322-d69o3z8d 66 1 However however RB cord-303322-d69o3z8d 66 2 in in IN cord-303322-d69o3z8d 66 3 our -PRON- PRP$ cord-303322-d69o3z8d 66 4 setting setting NN cord-303322-d69o3z8d 66 5 , , , cord-303322-d69o3z8d 66 6 there there EX cord-303322-d69o3z8d 66 7 are be VBP cord-303322-d69o3z8d 66 8 several several JJ cord-303322-d69o3z8d 66 9 reasons reason NNS cord-303322-d69o3z8d 66 10 why why WRB cord-303322-d69o3z8d 66 11 anti anti NNS cord-303322-d69o3z8d 66 12 - - NNS cord-303322-d69o3z8d 66 13 microbials microbial NNS cord-303322-d69o3z8d 66 14 may may MD cord-303322-d69o3z8d 66 15 reduce reduce VB cord-303322-d69o3z8d 66 16 the the DT cord-303322-d69o3z8d 66 17 morbidity morbidity NN cord-303322-d69o3z8d 66 18 of of IN cord-303322-d69o3z8d 66 19 hospitalised hospitalise VBN cord-303322-d69o3z8d 66 20 Indigenous indigenous JJ cord-303322-d69o3z8d 66 21 infants infant NNS cord-303322-d69o3z8d 66 22 with with IN cord-303322-d69o3z8d 66 23 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 66 24 . . . cord-303322-d69o3z8d 67 1 Colonisation colonisation NN cord-303322-d69o3z8d 67 2 of of IN cord-303322-d69o3z8d 67 3 nasopharynx nasopharynx NN cord-303322-d69o3z8d 67 4 with with IN cord-303322-d69o3z8d 67 5 bacteria bacteria NNS cord-303322-d69o3z8d 67 6 is be VBZ cord-303322-d69o3z8d 67 7 a a DT cord-303322-d69o3z8d 67 8 known know VBN cord-303322-d69o3z8d 67 9 risk risk NN cord-303322-d69o3z8d 67 10 factor factor NN cord-303322-d69o3z8d 67 11 for for IN cord-303322-d69o3z8d 67 12 childhood childhood NN cord-303322-d69o3z8d 67 13 pneumonia pneumonia NN cord-303322-d69o3z8d 67 14 [ [ -LRB- cord-303322-d69o3z8d 67 15 23 23 CD cord-303322-d69o3z8d 67 16 ] ] -RRB- cord-303322-d69o3z8d 67 17 . . . cord-303322-d69o3z8d 68 1 Indigenous indigenous JJ cord-303322-d69o3z8d 68 2 infants infant NNS cord-303322-d69o3z8d 68 3 not not RB cord-303322-d69o3z8d 68 4 only only RB cord-303322-d69o3z8d 68 5 have have VBP cord-303322-d69o3z8d 68 6 colonised colonise VBN cord-303322-d69o3z8d 68 7 nasopharynx nasopharynx NN cord-303322-d69o3z8d 68 8 very very RB cord-303322-d69o3z8d 68 9 early early RB cord-303322-d69o3z8d 68 10 in in IN cord-303322-d69o3z8d 68 11 life life NN cord-303322-d69o3z8d 68 12 ( ( -LRB- cord-303322-d69o3z8d 68 13 as as RB cord-303322-d69o3z8d 68 14 early early RB cord-303322-d69o3z8d 68 15 as as IN cord-303322-d69o3z8d 68 16 aged aged JJ cord-303322-d69o3z8d 68 17 2-weeks 2-weeks CD cord-303322-d69o3z8d 68 18 ) ) -RRB- cord-303322-d69o3z8d 68 19 , , , cord-303322-d69o3z8d 68 20 but but CC cord-303322-d69o3z8d 68 21 the the DT cord-303322-d69o3z8d 68 22 colonisation colonisation NN cord-303322-d69o3z8d 68 23 is be VBZ cord-303322-d69o3z8d 68 24 also also RB cord-303322-d69o3z8d 68 25 dense dense JJ cord-303322-d69o3z8d 68 26 with with IN cord-303322-d69o3z8d 68 27 common common JJ cord-303322-d69o3z8d 68 28 respiratory respiratory JJ cord-303322-d69o3z8d 68 29 bacterial bacterial JJ cord-303322-d69o3z8d 68 30 pathogens pathogen NNS cord-303322-d69o3z8d 68 31 , , , cord-303322-d69o3z8d 68 32 notably notably RB cord-303322-d69o3z8d 68 33 Streptococcus streptococcus NN cord-303322-d69o3z8d 68 34 pneumoniae pneumoniae NN cord-303322-d69o3z8d 68 35 , , , cord-303322-d69o3z8d 68 36 Haemophilus Haemophilus NNP cord-303322-d69o3z8d 68 37 infleunzae infleunzae NN cord-303322-d69o3z8d 68 38 and and CC cord-303322-d69o3z8d 68 39 Moraxella Moraxella NNP cord-303322-d69o3z8d 68 40 catarrhalis catarrhalis NNP cord-303322-d69o3z8d 68 41 [ [ -LRB- cord-303322-d69o3z8d 68 42 24 24 CD cord-303322-d69o3z8d 68 43 ] ] -RRB- cord-303322-d69o3z8d 68 44 . . . cord-303322-d69o3z8d 69 1 Repeated repeat VBN cord-303322-d69o3z8d 69 2 micro micro NN cord-303322-d69o3z8d 69 3 - - NN cord-303322-d69o3z8d 69 4 aspiration aspiration NN cord-303322-d69o3z8d 69 5 of of IN cord-303322-d69o3z8d 69 6 nasopharyngeal nasopharyngeal JJ cord-303322-d69o3z8d 69 7 secretions secretion NNS cord-303322-d69o3z8d 69 8 heavily heavily RB cord-303322-d69o3z8d 69 9 laden laden JJ cord-303322-d69o3z8d 69 10 with with IN cord-303322-d69o3z8d 69 11 pathogenic pathogenic JJ cord-303322-d69o3z8d 69 12 bacteria bacteria NNS cord-303322-d69o3z8d 69 13 during during IN cord-303322-d69o3z8d 69 14 ALRI ALRI NNP cord-303322-d69o3z8d 69 15 may may MD cord-303322-d69o3z8d 69 16 overwhelm overwhelm VB cord-303322-d69o3z8d 69 17 already already RB cord-303322-d69o3z8d 69 18 compromised compromise VBN cord-303322-d69o3z8d 69 19 pulmonary pulmonary JJ cord-303322-d69o3z8d 69 20 defences defence NNS cord-303322-d69o3z8d 69 21 , , , cord-303322-d69o3z8d 69 22 increasing increase VBG cord-303322-d69o3z8d 69 23 the the DT cord-303322-d69o3z8d 69 24 risk risk NN cord-303322-d69o3z8d 69 25 of of IN cord-303322-d69o3z8d 69 26 a a DT cord-303322-d69o3z8d 69 27 secondary secondary JJ cord-303322-d69o3z8d 69 28 pneumonia pneumonia NN cord-303322-d69o3z8d 69 29 or or CC cord-303322-d69o3z8d 69 30 other other JJ cord-303322-d69o3z8d 69 31 lower low JJR cord-303322-d69o3z8d 69 32 airway airway NN cord-303322-d69o3z8d 69 33 infection infection NN cord-303322-d69o3z8d 69 34 . . . cord-303322-d69o3z8d 70 1 Indeed indeed RB cord-303322-d69o3z8d 70 2 , , , cord-303322-d69o3z8d 70 3 Indigenous indigenous JJ cord-303322-d69o3z8d 70 4 infants infant NNS cord-303322-d69o3z8d 70 5 are be VBP cord-303322-d69o3z8d 70 6 more more RBR cord-303322-d69o3z8d 70 7 likely likely JJ cord-303322-d69o3z8d 70 8 to to TO cord-303322-d69o3z8d 70 9 receive receive VB cord-303322-d69o3z8d 70 10 antibiotics antibiotic NNS cord-303322-d69o3z8d 70 11 for for IN cord-303322-d69o3z8d 70 12 an an DT cord-303322-d69o3z8d 70 13 episode episode NN cord-303322-d69o3z8d 70 14 of of IN cord-303322-d69o3z8d 70 15 pneumonia pneumonia NN cord-303322-d69o3z8d 70 16 diagnosed diagnose VBN cord-303322-d69o3z8d 70 17 during during IN cord-303322-d69o3z8d 70 18 an an DT cord-303322-d69o3z8d 70 19 admission admission NN cord-303322-d69o3z8d 70 20 for for IN cord-303322-d69o3z8d 70 21 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 70 22 than than IN cord-303322-d69o3z8d 70 23 non non JJ cord-303322-d69o3z8d 70 24 - - JJ cord-303322-d69o3z8d 70 25 Indigenous indigenous JJ cord-303322-d69o3z8d 70 26 infants infant NNS cord-303322-d69o3z8d 70 27 nursed nurse VBN cord-303322-d69o3z8d 70 28 in in IN cord-303322-d69o3z8d 70 29 the the DT cord-303322-d69o3z8d 70 30 same same JJ cord-303322-d69o3z8d 70 31 paediatric paediatric JJ cord-303322-d69o3z8d 70 32 unit unit NN cord-303322-d69o3z8d 70 33 [ [ -LRB- cord-303322-d69o3z8d 70 34 6 6 CD cord-303322-d69o3z8d 70 35 ] ] -RRB- cord-303322-d69o3z8d 70 36 . . . cord-303322-d69o3z8d 71 1 Macrolides macrolide NNS cord-303322-d69o3z8d 71 2 are be VBP cord-303322-d69o3z8d 71 3 a a DT cord-303322-d69o3z8d 71 4 class class NN cord-303322-d69o3z8d 71 5 of of IN cord-303322-d69o3z8d 71 6 antibiotics antibiotic NNS cord-303322-d69o3z8d 71 7 containing contain VBG cord-303322-d69o3z8d 71 8 a a DT cord-303322-d69o3z8d 71 9 macrocyclic macrocyclic JJ cord-303322-d69o3z8d 71 10 lactone lactone NN cord-303322-d69o3z8d 71 11 ring ring NN cord-303322-d69o3z8d 71 12 with with IN cord-303322-d69o3z8d 71 13 excellent excellent JJ cord-303322-d69o3z8d 71 14 tissue tissue NN cord-303322-d69o3z8d 71 15 penetration penetration NN cord-303322-d69o3z8d 71 16 and and CC cord-303322-d69o3z8d 71 17 antimicrobial antimicrobial JJ cord-303322-d69o3z8d 71 18 activity activity NN cord-303322-d69o3z8d 71 19 against against IN cord-303322-d69o3z8d 71 20 a a DT cord-303322-d69o3z8d 71 21 broad broad JJ cord-303322-d69o3z8d 71 22 range range NN cord-303322-d69o3z8d 71 23 of of IN cord-303322-d69o3z8d 71 24 gram gram NN cord-303322-d69o3z8d 71 25 positive positive JJ cord-303322-d69o3z8d 71 26 and and CC cord-303322-d69o3z8d 71 27 gram gram JJ cord-303322-d69o3z8d 71 28 negative negative JJ cord-303322-d69o3z8d 71 29 bacteria bacteria NNS cord-303322-d69o3z8d 71 30 , , , cord-303322-d69o3z8d 71 31 including include VBG cord-303322-d69o3z8d 71 32 intracellular intracellular JJ cord-303322-d69o3z8d 71 33 pathogens pathogen NNS cord-303322-d69o3z8d 71 34 such such JJ cord-303322-d69o3z8d 71 35 as as IN cord-303322-d69o3z8d 71 36 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 71 37 . . . cord-303322-d69o3z8d 72 1 Those those DT cord-303322-d69o3z8d 72 2 with with IN cord-303322-d69o3z8d 72 3 a a DT cord-303322-d69o3z8d 72 4 14-or 14-or CD cord-303322-d69o3z8d 72 5 15-membered 15-membered CD cord-303322-d69o3z8d 72 6 lactone lactone NN cord-303322-d69o3z8d 72 7 ring ring NN cord-303322-d69o3z8d 72 8 also also RB cord-303322-d69o3z8d 72 9 have have VBP cord-303322-d69o3z8d 72 10 several several JJ cord-303322-d69o3z8d 72 11 non non JJ cord-303322-d69o3z8d 72 12 - - JJ cord-303322-d69o3z8d 72 13 antimicrobial antimicrobial JJ cord-303322-d69o3z8d 72 14 properties property NNS cord-303322-d69o3z8d 72 15 that that WDT cord-303322-d69o3z8d 72 16 have have VBP cord-303322-d69o3z8d 72 17 been be VBN cord-303322-d69o3z8d 72 18 studied study VBN cord-303322-d69o3z8d 72 19 extensively extensively RB cord-303322-d69o3z8d 72 20 in in IN cord-303322-d69o3z8d 72 21 - - HYPH cord-303322-d69o3z8d 72 22 vitro vitro FW cord-303322-d69o3z8d 72 23 and and CC cord-303322-d69o3z8d 72 24 in in IN cord-303322-d69o3z8d 72 25 experimental experimental JJ cord-303322-d69o3z8d 72 26 models model NNS cord-303322-d69o3z8d 72 27 and and CC cord-303322-d69o3z8d 72 28 , , , cord-303322-d69o3z8d 72 29 to to IN cord-303322-d69o3z8d 72 30 a a DT cord-303322-d69o3z8d 72 31 lesser less JJR cord-303322-d69o3z8d 72 32 extent extent NN cord-303322-d69o3z8d 72 33 , , , cord-303322-d69o3z8d 72 34 in in IN cord-303322-d69o3z8d 72 35 humans human NNS cord-303322-d69o3z8d 72 36 [ [ -LRB- cord-303322-d69o3z8d 72 37 25 25 CD cord-303322-d69o3z8d 72 38 ] ] -RRB- cord-303322-d69o3z8d 72 39 . . . cord-303322-d69o3z8d 73 1 One one CD cord-303322-d69o3z8d 73 2 of of IN cord-303322-d69o3z8d 73 3 these these DT cord-303322-d69o3z8d 73 4 effects effect NNS cord-303322-d69o3z8d 73 5 is be VBZ cord-303322-d69o3z8d 73 6 modulation modulation NN cord-303322-d69o3z8d 73 7 of of IN cord-303322-d69o3z8d 73 8 the the DT cord-303322-d69o3z8d 73 9 immune immune JJ cord-303322-d69o3z8d 73 10 response response NN cord-303322-d69o3z8d 73 11 . . . cord-303322-d69o3z8d 74 1 The the DT cord-303322-d69o3z8d 74 2 immune immune JJ cord-303322-d69o3z8d 74 3 modulating modulate VBG cord-303322-d69o3z8d 74 4 properties property NNS cord-303322-d69o3z8d 74 5 of of IN cord-303322-d69o3z8d 74 6 macrolides macrolide NNS cord-303322-d69o3z8d 74 7 make make VBP cord-303322-d69o3z8d 74 8 them -PRON- PRP cord-303322-d69o3z8d 74 9 attractive attractive JJ cord-303322-d69o3z8d 74 10 candidates candidate NNS cord-303322-d69o3z8d 74 11 for for IN cord-303322-d69o3z8d 74 12 treating treat VBG cord-303322-d69o3z8d 74 13 inflammatory inflammatory JJ cord-303322-d69o3z8d 74 14 airways airway NNS cord-303322-d69o3z8d 74 15 diseases disease NNS cord-303322-d69o3z8d 74 16 . . . cord-303322-d69o3z8d 75 1 The the DT cord-303322-d69o3z8d 75 2 two two CD cord-303322-d69o3z8d 75 3 published publish VBN cord-303322-d69o3z8d 75 4 [ [ -LRB- cord-303322-d69o3z8d 75 5 26 26 CD cord-303322-d69o3z8d 75 6 , , , cord-303322-d69o3z8d 75 7 27 27 CD cord-303322-d69o3z8d 75 8 ] ] -RRB- cord-303322-d69o3z8d 75 9 placebo placebo NN cord-303322-d69o3z8d 75 10 - - HYPH cord-303322-d69o3z8d 75 11 controlled control VBN cord-303322-d69o3z8d 75 12 RCTs rct NNS cord-303322-d69o3z8d 75 13 on on IN cord-303322-d69o3z8d 75 14 macrolides macrolide NNS cord-303322-d69o3z8d 75 15 for for IN cord-303322-d69o3z8d 75 16 RSV RSV NNP cord-303322-d69o3z8d 75 17 - - HYPH cord-303322-d69o3z8d 75 18 bronchiolitis bronchiolitis NNP cord-303322-d69o3z8d 75 19 reported report VBD cord-303322-d69o3z8d 75 20 contradictory contradictory JJ cord-303322-d69o3z8d 75 21 results result NNS cord-303322-d69o3z8d 75 22 . . . cord-303322-d69o3z8d 76 1 In in IN cord-303322-d69o3z8d 76 2 a a DT cord-303322-d69o3z8d 76 3 small small JJ cord-303322-d69o3z8d 76 4 Turkish turkish JJ cord-303322-d69o3z8d 76 5 study study NN cord-303322-d69o3z8d 76 6 of of IN cord-303322-d69o3z8d 76 7 21 21 CD cord-303322-d69o3z8d 76 8 hospitalised hospitalise VBN cord-303322-d69o3z8d 76 9 infants infant NNS cord-303322-d69o3z8d 76 10 with with IN cord-303322-d69o3z8d 76 11 moderate moderate JJ cord-303322-d69o3z8d 76 12 to to IN cord-303322-d69o3z8d 76 13 severe severe JJ cord-303322-d69o3z8d 76 14 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 76 15 , , , cord-303322-d69o3z8d 76 16 3-weeks 3-weeks CD cord-303322-d69o3z8d 76 17 of of IN cord-303322-d69o3z8d 76 18 daily daily JJ cord-303322-d69o3z8d 76 19 clarithromycin clarithromycin NNP cord-303322-d69o3z8d 76 20 significantly significantly RB cord-303322-d69o3z8d 76 21 reduced reduce VBD cord-303322-d69o3z8d 76 22 severity severity NN cord-303322-d69o3z8d 76 23 of of IN cord-303322-d69o3z8d 76 24 illness illness NN cord-303322-d69o3z8d 76 25 ( ( -LRB- cord-303322-d69o3z8d 76 26 oxygen oxygen NN cord-303322-d69o3z8d 76 27 use use NN cord-303322-d69o3z8d 76 28 , , , cord-303322-d69o3z8d 76 29 hospital hospital NN cord-303322-d69o3z8d 76 30 stay stay NN cord-303322-d69o3z8d 76 31 ) ) -RRB- cord-303322-d69o3z8d 76 32 and and CC cord-303322-d69o3z8d 76 33 risk risk NN cord-303322-d69o3z8d 76 34 of of IN cord-303322-d69o3z8d 76 35 hospital hospital NN cord-303322-d69o3z8d 76 36 readmission readmission NN cord-303322-d69o3z8d 76 37 for for IN cord-303322-d69o3z8d 76 38 respiratory respiratory JJ cord-303322-d69o3z8d 76 39 illness illness NN cord-303322-d69o3z8d 76 40 during during IN cord-303322-d69o3z8d 76 41 the the DT cord-303322-d69o3z8d 76 42 next next JJ cord-303322-d69o3z8d 76 43 6 6 CD cord-303322-d69o3z8d 76 44 months month NNS cord-303322-d69o3z8d 76 45 [ [ -LRB- cord-303322-d69o3z8d 76 46 26 26 CD cord-303322-d69o3z8d 76 47 ] ] -RRB- cord-303322-d69o3z8d 76 48 . . . cord-303322-d69o3z8d 77 1 However however RB cord-303322-d69o3z8d 77 2 in in IN cord-303322-d69o3z8d 77 3 another another DT cord-303322-d69o3z8d 77 4 larger large JJR cord-303322-d69o3z8d 77 5 study study NN cord-303322-d69o3z8d 77 6 involving involve VBG cord-303322-d69o3z8d 77 7 71 71 CD cord-303322-d69o3z8d 77 8 infants infant NNS cord-303322-d69o3z8d 77 9 from from IN cord-303322-d69o3z8d 77 10 the the DT cord-303322-d69o3z8d 77 11 Netherlands Netherlands NNP cord-303322-d69o3z8d 77 12 , , , cord-303322-d69o3z8d 77 13 3-days 3-days CD cord-303322-d69o3z8d 77 14 of of IN cord-303322-d69o3z8d 77 15 azithromycin azithromycin NNP cord-303322-d69o3z8d 77 16 was be VBD cord-303322-d69o3z8d 77 17 not not RB cord-303322-d69o3z8d 77 18 efficacious efficacious JJ cord-303322-d69o3z8d 77 19 in in IN cord-303322-d69o3z8d 77 20 infants infant NNS cord-303322-d69o3z8d 77 21 hospitalised hospitalise VBN cord-303322-d69o3z8d 77 22 with with IN cord-303322-d69o3z8d 77 23 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 77 24 [ [ -LRB- cord-303322-d69o3z8d 77 25 27 27 CD cord-303322-d69o3z8d 77 26 ] ] -RRB- cord-303322-d69o3z8d 77 27 . . . cord-303322-d69o3z8d 78 1 The the DT cord-303322-d69o3z8d 78 2 difference difference NN cord-303322-d69o3z8d 78 3 in in IN cord-303322-d69o3z8d 78 4 outcomes outcome NNS cord-303322-d69o3z8d 78 5 seen see VBN cord-303322-d69o3z8d 78 6 in in IN cord-303322-d69o3z8d 78 7 the the DT cord-303322-d69o3z8d 78 8 two two CD cord-303322-d69o3z8d 78 9 trials trial NNS cord-303322-d69o3z8d 78 10 may may MD cord-303322-d69o3z8d 78 11 be be VB cord-303322-d69o3z8d 78 12 related relate VBN cord-303322-d69o3z8d 78 13 to to IN cord-303322-d69o3z8d 78 14 the the DT cord-303322-d69o3z8d 78 15 dose dose NN cord-303322-d69o3z8d 78 16 or or CC cord-303322-d69o3z8d 78 17 length length NN cord-303322-d69o3z8d 78 18 of of IN cord-303322-d69o3z8d 78 19 treatment treatment NN cord-303322-d69o3z8d 78 20 , , , cord-303322-d69o3z8d 78 21 chance chance NN cord-303322-d69o3z8d 78 22 , , , cord-303322-d69o3z8d 78 23 or or CC cord-303322-d69o3z8d 78 24 heterogeneity heterogeneity NN cord-303322-d69o3z8d 78 25 of of IN cord-303322-d69o3z8d 78 26 the the DT cord-303322-d69o3z8d 78 27 study study NN cord-303322-d69o3z8d 78 28 populations population NNS cord-303322-d69o3z8d 78 29 . . . cord-303322-d69o3z8d 79 1 Infants infant NNS cord-303322-d69o3z8d 79 2 in in IN cord-303322-d69o3z8d 79 3 Turkey Turkey NNP cord-303322-d69o3z8d 79 4 are be VBP cord-303322-d69o3z8d 79 5 more more RBR cord-303322-d69o3z8d 79 6 likely likely JJ cord-303322-d69o3z8d 79 7 to to TO cord-303322-d69o3z8d 79 8 have have VB cord-303322-d69o3z8d 79 9 concomitant concomitant JJ cord-303322-d69o3z8d 79 10 bacterial bacterial JJ cord-303322-d69o3z8d 79 11 infection infection NN cord-303322-d69o3z8d 79 12 compared compare VBN cord-303322-d69o3z8d 79 13 to to IN cord-303322-d69o3z8d 79 14 an an DT cord-303322-d69o3z8d 79 15 affluent affluent JJ cord-303322-d69o3z8d 79 16 European european JJ cord-303322-d69o3z8d 79 17 group group NN cord-303322-d69o3z8d 79 18 and and CC cord-303322-d69o3z8d 79 19 moreover moreover RB cord-303322-d69o3z8d 79 20 in in IN cord-303322-d69o3z8d 79 21 Turkey Turkey NNP cord-303322-d69o3z8d 79 22 , , , cord-303322-d69o3z8d 79 23 post post JJ cord-303322-d69o3z8d 79 24 - - JJ cord-303322-d69o3z8d 79 25 infectious infectious JJ cord-303322-d69o3z8d 79 26 childhood childhood NN cord-303322-d69o3z8d 79 27 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 79 28 remains remain VBZ cord-303322-d69o3z8d 79 29 an an DT cord-303322-d69o3z8d 79 30 important important JJ cord-303322-d69o3z8d 79 31 health health NN cord-303322-d69o3z8d 79 32 problem problem NN cord-303322-d69o3z8d 79 33 [ [ -LRB- cord-303322-d69o3z8d 79 34 28 28 CD cord-303322-d69o3z8d 79 35 ] ] -RRB- cord-303322-d69o3z8d 79 36 . . . cord-303322-d69o3z8d 80 1 The the DT cord-303322-d69o3z8d 80 2 populations population NNS cord-303322-d69o3z8d 80 3 also also RB cord-303322-d69o3z8d 80 4 differed differ VBD cord-303322-d69o3z8d 80 5 in in IN cord-303322-d69o3z8d 80 6 age age NN cord-303322-d69o3z8d 80 7 . . . cord-303322-d69o3z8d 81 1 The the DT cord-303322-d69o3z8d 81 2 European european JJ cord-303322-d69o3z8d 81 3 study study NN cord-303322-d69o3z8d 81 4 included include VBD cord-303322-d69o3z8d 81 5 infants infant NNS cord-303322-d69o3z8d 81 6 up up RP cord-303322-d69o3z8d 81 7 to to IN cord-303322-d69o3z8d 81 8 24-months 24-months CD cord-303322-d69o3z8d 81 9 of of IN cord-303322-d69o3z8d 81 10 age age NN cord-303322-d69o3z8d 81 11 , , , cord-303322-d69o3z8d 81 12 whereas whereas IN cord-303322-d69o3z8d 81 13 the the DT cord-303322-d69o3z8d 81 14 Turkish turkish JJ cord-303322-d69o3z8d 81 15 study study NN cord-303322-d69o3z8d 81 16 involved involve VBN cord-303322-d69o3z8d 81 17 only only RB cord-303322-d69o3z8d 81 18 infants infant NNS cord-303322-d69o3z8d 81 19 aged age VBN cord-303322-d69o3z8d 81 20 < < XX cord-303322-d69o3z8d 81 21 7-months 7-months CD cord-303322-d69o3z8d 81 22 [ [ -LRB- cord-303322-d69o3z8d 81 23 26 26 CD cord-303322-d69o3z8d 81 24 , , , cord-303322-d69o3z8d 81 25 27 27 CD cord-303322-d69o3z8d 81 26 ] ] -RRB- cord-303322-d69o3z8d 81 27 . . . cord-303322-d69o3z8d 82 1 Clearly clearly RB cord-303322-d69o3z8d 82 2 , , , cord-303322-d69o3z8d 82 3 a a DT cord-303322-d69o3z8d 82 4 well well RB cord-303322-d69o3z8d 82 5 designed design VBN cord-303322-d69o3z8d 82 6 RCT RCT NNP cord-303322-d69o3z8d 82 7 on on IN cord-303322-d69o3z8d 82 8 the the DT cord-303322-d69o3z8d 82 9 efficacy efficacy NN cord-303322-d69o3z8d 82 10 of of IN cord-303322-d69o3z8d 82 11 macrolides macrolide NNS cord-303322-d69o3z8d 82 12 to to TO cord-303322-d69o3z8d 82 13 reduce reduce VB cord-303322-d69o3z8d 82 14 the the DT cord-303322-d69o3z8d 82 15 burden burden NN cord-303322-d69o3z8d 82 16 of of IN cord-303322-d69o3z8d 82 17 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 82 18 in in IN cord-303322-d69o3z8d 82 19 a a DT cord-303322-d69o3z8d 82 20 population population NN cord-303322-d69o3z8d 82 21 at at IN cord-303322-d69o3z8d 82 22 high high JJ cord-303322-d69o3z8d 82 23 risk risk NN cord-303322-d69o3z8d 82 24 of of IN cord-303322-d69o3z8d 82 25 acute acute JJ cord-303322-d69o3z8d 82 26 and and CC cord-303322-d69o3z8d 82 27 chronic chronic JJ cord-303322-d69o3z8d 82 28 respiratory respiratory JJ cord-303322-d69o3z8d 82 29 disease disease NN cord-303322-d69o3z8d 82 30 would would MD cord-303322-d69o3z8d 82 31 be be VB cord-303322-d69o3z8d 82 32 beneficial beneficial JJ cord-303322-d69o3z8d 82 33 . . . cord-303322-d69o3z8d 83 1 Our -PRON- PRP$ cord-303322-d69o3z8d 83 2 primary primary JJ cord-303322-d69o3z8d 83 3 research research NN cord-303322-d69o3z8d 83 4 question question NN cord-303322-d69o3z8d 83 5 is be VBZ cord-303322-d69o3z8d 83 6 : : : cord-303322-d69o3z8d 84 1 Amongst amongst IN cord-303322-d69o3z8d 84 2 hospitalised hospitalise VBN cord-303322-d69o3z8d 84 3 Indigenous indigenous JJ cord-303322-d69o3z8d 84 4 infants infant NNS cord-303322-d69o3z8d 84 5 with with IN cord-303322-d69o3z8d 84 6 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 84 7 , , , cord-303322-d69o3z8d 84 8 does do VBZ cord-303322-d69o3z8d 84 9 azithromycin azithromycin NN cord-303322-d69o3z8d 84 10 ( ( -LRB- cord-303322-d69o3z8d 84 11 compared compare VBN cord-303322-d69o3z8d 84 12 to to IN cord-303322-d69o3z8d 84 13 placebo placebo NN cord-303322-d69o3z8d 84 14 ) ) -RRB- cord-303322-d69o3z8d 84 15 improve improve VB cord-303322-d69o3z8d 84 16 clinical clinical JJ cord-303322-d69o3z8d 84 17 outcomes outcome NNS cord-303322-d69o3z8d 84 18 ( ( -LRB- cord-303322-d69o3z8d 84 19 length length NN cord-303322-d69o3z8d 84 20 of of IN cord-303322-d69o3z8d 84 21 stay stay NN cord-303322-d69o3z8d 84 22 in in IN cord-303322-d69o3z8d 84 23 hospital hospital NN cord-303322-d69o3z8d 84 24 and and CC cord-303322-d69o3z8d 84 25 duration duration NN cord-303322-d69o3z8d 84 26 of of IN cord-303322-d69o3z8d 84 27 oxygen oxygen NN cord-303322-d69o3z8d 84 28 supplementation supplementation NN cord-303322-d69o3z8d 84 29 ) ) -RRB- cord-303322-d69o3z8d 84 30 ? ? . cord-303322-d69o3z8d 85 1 Our -PRON- PRP$ cord-303322-d69o3z8d 85 2 primary primary JJ cord-303322-d69o3z8d 85 3 hypothesis hypothesis NN cord-303322-d69o3z8d 85 4 is be VBZ cord-303322-d69o3z8d 85 5 that that DT cord-303322-d69o3z8d 85 6 : : : cord-303322-d69o3z8d 85 7 The the DT cord-303322-d69o3z8d 85 8 anti anti JJ cord-303322-d69o3z8d 85 9 - - JJ cord-303322-d69o3z8d 85 10 microbial microbial JJ cord-303322-d69o3z8d 85 11 and and CC cord-303322-d69o3z8d 85 12 anti anti JJ cord-303322-d69o3z8d 85 13 - - JJ cord-303322-d69o3z8d 85 14 inflammatory inflammatory JJ cord-303322-d69o3z8d 85 15 properties property NNS cord-303322-d69o3z8d 85 16 of of IN cord-303322-d69o3z8d 85 17 the the DT cord-303322-d69o3z8d 85 18 macrolide macrolide NN cord-303322-d69o3z8d 85 19 , , , cord-303322-d69o3z8d 85 20 azithromycin azithromycin NNP cord-303322-d69o3z8d 85 21 , , , cord-303322-d69o3z8d 85 22 will will MD cord-303322-d69o3z8d 85 23 improve improve VB cord-303322-d69o3z8d 85 24 the the DT cord-303322-d69o3z8d 85 25 clinical clinical JJ cord-303322-d69o3z8d 85 26 outcomes outcome NNS cord-303322-d69o3z8d 85 27 of of IN cord-303322-d69o3z8d 85 28 Indigenous indigenous JJ cord-303322-d69o3z8d 85 29 infants infant NNS cord-303322-d69o3z8d 85 30 hospitalised hospitalise VBN cord-303322-d69o3z8d 85 31 with with IN cord-303322-d69o3z8d 85 32 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 85 33 . . . cord-303322-d69o3z8d 86 1 Our -PRON- PRP$ cord-303322-d69o3z8d 86 2 secondary secondary JJ cord-303322-d69o3z8d 86 3 aims aim NNS cord-303322-d69o3z8d 86 4 are be VBP cord-303322-d69o3z8d 86 5 : : : cord-303322-d69o3z8d 86 6 2 2 CD cord-303322-d69o3z8d 86 7 . . . cord-303322-d69o3z8d 87 1 To to TO cord-303322-d69o3z8d 87 2 determine determine VB cord-303322-d69o3z8d 87 3 the the DT cord-303322-d69o3z8d 87 4 effect effect NN cord-303322-d69o3z8d 87 5 of of IN cord-303322-d69o3z8d 87 6 azithromycin azithromycin NN cord-303322-d69o3z8d 87 7 on on IN cord-303322-d69o3z8d 87 8 readmissions readmission NNS cord-303322-d69o3z8d 87 9 into into IN cord-303322-d69o3z8d 87 10 hospital hospital NN cord-303322-d69o3z8d 87 11 within within IN cord-303322-d69o3z8d 87 12 6 6 CD cord-303322-d69o3z8d 87 13 months month NNS cord-303322-d69o3z8d 87 14 of of IN cord-303322-d69o3z8d 87 15 treatment treatment NN cord-303322-d69o3z8d 87 16 ; ; : cord-303322-d69o3z8d 87 17 3 3 CD cord-303322-d69o3z8d 87 18 . . . cord-303322-d69o3z8d 88 1 To to TO cord-303322-d69o3z8d 88 2 assess assess VB cord-303322-d69o3z8d 88 3 the the DT cord-303322-d69o3z8d 88 4 short short JJ cord-303322-d69o3z8d 88 5 - - HYPH cord-303322-d69o3z8d 88 6 term term NN cord-303322-d69o3z8d 88 7 impact impact NN cord-303322-d69o3z8d 88 8 of of IN cord-303322-d69o3z8d 88 9 azithromycin azithromycin NN cord-303322-d69o3z8d 88 10 on on IN cord-303322-d69o3z8d 88 11 macrolide macrolide JJ cord-303322-d69o3z8d 88 12 resistance resistance NN cord-303322-d69o3z8d 88 13 patterns pattern NNS cord-303322-d69o3z8d 88 14 of of IN cord-303322-d69o3z8d 88 15 respiratory respiratory JJ cord-303322-d69o3z8d 88 16 bacterial bacterial JJ cord-303322-d69o3z8d 88 17 pathogens pathogen NNS cord-303322-d69o3z8d 88 18 in in IN cord-303322-d69o3z8d 88 19 the the DT cord-303322-d69o3z8d 88 20 nasopharynx nasopharynx NN cord-303322-d69o3z8d 88 21 ; ; : cord-303322-d69o3z8d 88 22 and and CC cord-303322-d69o3z8d 88 23 4 4 CD cord-303322-d69o3z8d 88 24 . . . cord-303322-d69o3z8d 89 1 To to TO cord-303322-d69o3z8d 89 2 describe describe VB cord-303322-d69o3z8d 89 3 the the DT cord-303322-d69o3z8d 89 4 point point NN cord-303322-d69o3z8d 89 5 prevalence prevalence NN cord-303322-d69o3z8d 89 6 and and CC cord-303322-d69o3z8d 89 7 diversity diversity NN cord-303322-d69o3z8d 89 8 of of IN cord-303322-d69o3z8d 89 9 respiratory respiratory JJ cord-303322-d69o3z8d 89 10 viruses virus NNS cord-303322-d69o3z8d 89 11 , , , cord-303322-d69o3z8d 89 12 Mycoplasma mycoplasma NN cord-303322-d69o3z8d 89 13 pneumoniae pneumoniae NN cord-303322-d69o3z8d 89 14 and and CC cord-303322-d69o3z8d 89 15 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 89 16 species specie NNS cord-303322-d69o3z8d 89 17 using use VBG cord-303322-d69o3z8d 89 18 sensitive sensitive JJ cord-303322-d69o3z8d 89 19 molecular molecular JJ cord-303322-d69o3z8d 89 20 diagnostic diagnostic JJ cord-303322-d69o3z8d 89 21 techniques technique NNS cord-303322-d69o3z8d 89 22 . . . cord-303322-d69o3z8d 90 1 We -PRON- PRP cord-303322-d69o3z8d 90 2 are be VBP cord-303322-d69o3z8d 90 3 conducting conduct VBG cord-303322-d69o3z8d 90 4 a a DT cord-303322-d69o3z8d 90 5 parallel parallel JJ cord-303322-d69o3z8d 90 6 group group NN cord-303322-d69o3z8d 90 7 , , , cord-303322-d69o3z8d 90 8 double double JJ cord-303322-d69o3z8d 90 9 - - HYPH cord-303322-d69o3z8d 90 10 blind blind JJ cord-303322-d69o3z8d 90 11 placebo placebo NN cord-303322-d69o3z8d 90 12 RCT RCT NNP cord-303322-d69o3z8d 90 13 ( ( -LRB- cord-303322-d69o3z8d 90 14 with with IN cord-303322-d69o3z8d 90 15 concealed conceal VBN cord-303322-d69o3z8d 90 16 allocation allocation NN cord-303322-d69o3z8d 90 17 ) ) -RRB- cord-303322-d69o3z8d 90 18 to to TO cord-303322-d69o3z8d 90 19 assess assess VB cord-303322-d69o3z8d 90 20 the the DT cord-303322-d69o3z8d 90 21 impact impact NN cord-303322-d69o3z8d 90 22 of of IN cord-303322-d69o3z8d 90 23 additional additional JJ cord-303322-d69o3z8d 90 24 treatment treatment NN cord-303322-d69o3z8d 90 25 with with IN cord-303322-d69o3z8d 90 26 azithromycin azithromycin NNP cord-303322-d69o3z8d 90 27 in in IN cord-303322-d69o3z8d 90 28 Indigenous indigenous JJ cord-303322-d69o3z8d 90 29 infants infant NNS cord-303322-d69o3z8d 90 30 admitted admit VBD cord-303322-d69o3z8d 90 31 to to IN cord-303322-d69o3z8d 90 32 two two CD cord-303322-d69o3z8d 90 33 regional regional JJ cord-303322-d69o3z8d 90 34 hospitals hospital NNS cord-303322-d69o3z8d 90 35 ( ( -LRB- cord-303322-d69o3z8d 90 36 Darwin Darwin NNP cord-303322-d69o3z8d 90 37 , , , cord-303322-d69o3z8d 90 38 Northern Northern NNP cord-303322-d69o3z8d 90 39 Territory Territory NNP cord-303322-d69o3z8d 90 40 and and CC cord-303322-d69o3z8d 90 41 Townsville Townsville NNP cord-303322-d69o3z8d 90 42 , , , cord-303322-d69o3z8d 90 43 Queensland Queensland NNP cord-303322-d69o3z8d 90 44 ) ) -RRB- cord-303322-d69o3z8d 90 45 with with IN cord-303322-d69o3z8d 90 46 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 90 47 . . . cord-303322-d69o3z8d 91 1 Our -PRON- PRP$ cord-303322-d69o3z8d 91 2 study study NN cord-303322-d69o3z8d 91 3 plan plan NN cord-303322-d69o3z8d 91 4 is be VBZ cord-303322-d69o3z8d 91 5 summarised summarise VBN cord-303322-d69o3z8d 91 6 in in IN cord-303322-d69o3z8d 91 7 Figure Figure NNP cord-303322-d69o3z8d 91 8 1 1 CD cord-303322-d69o3z8d 91 9 . . . cord-303322-d69o3z8d 92 1 The the DT cord-303322-d69o3z8d 92 2 inclusion inclusion NN cord-303322-d69o3z8d 92 3 criteria criterion NNS cord-303322-d69o3z8d 92 4 are be VBP cord-303322-d69o3z8d 92 5 : : : cord-303322-d69o3z8d 92 6 Baseline baseline JJ cord-303322-d69o3z8d 92 7 data datum NNS cord-303322-d69o3z8d 92 8 , , , cord-303322-d69o3z8d 92 9 NPS-1 NPS-1 NNP cord-303322-d69o3z8d 92 10 1 1 CD cord-303322-d69o3z8d 92 11 . . . cord-303322-d69o3z8d 93 1 Indigenous indigenous JJ cord-303322-d69o3z8d 93 2 infants infant NNS cord-303322-d69o3z8d 93 3 ( ( -LRB- cord-303322-d69o3z8d 93 4 aged aged JJ cord-303322-d69o3z8d 93 5 ≤ ≤ NN cord-303322-d69o3z8d 93 6 24-months 24-months CD cord-303322-d69o3z8d 93 7 ) ) -RRB- cord-303322-d69o3z8d 93 8 admitted admit VBD cord-303322-d69o3z8d 93 9 to to IN cord-303322-d69o3z8d 93 10 one one CD cord-303322-d69o3z8d 93 11 of of IN cord-303322-d69o3z8d 93 12 our -PRON- PRP$ cord-303322-d69o3z8d 93 13 hospitals hospital NNS cord-303322-d69o3z8d 93 14 ( ( -LRB- cord-303322-d69o3z8d 93 15 Darwin Darwin NNP cord-303322-d69o3z8d 93 16 and and CC cord-303322-d69o3z8d 93 17 Townsville Townsville NNP cord-303322-d69o3z8d 93 18 ) ) -RRB- cord-303322-d69o3z8d 93 19 with with IN cord-303322-d69o3z8d 93 20 a a DT cord-303322-d69o3z8d 93 21 clinical clinical JJ cord-303322-d69o3z8d 93 22 diagnosis diagnosis NN cord-303322-d69o3z8d 93 23 of of IN cord-303322-d69o3z8d 93 24 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 93 25 . . . cord-303322-d69o3z8d 94 1 In in IN cord-303322-d69o3z8d 94 2 the the DT cord-303322-d69o3z8d 94 3 absence absence NN cord-303322-d69o3z8d 94 4 of of IN cord-303322-d69o3z8d 94 5 an an DT cord-303322-d69o3z8d 94 6 international international JJ cord-303322-d69o3z8d 94 7 standardised standardised JJ cord-303322-d69o3z8d 94 8 diagnosis diagnosis NN cord-303322-d69o3z8d 94 9 of of IN cord-303322-d69o3z8d 94 10 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 94 11 , , , cord-303322-d69o3z8d 94 12 [ [ -LRB- cord-303322-d69o3z8d 94 13 29 29 CD cord-303322-d69o3z8d 94 14 , , , cord-303322-d69o3z8d 94 15 30 30 CD cord-303322-d69o3z8d 94 16 ] ] -RRB- cord-303322-d69o3z8d 94 17 the the DT cord-303322-d69o3z8d 94 18 accepted accept VBN cord-303322-d69o3z8d 94 19 Australian australian JJ cord-303322-d69o3z8d 94 20 clinical clinical JJ cord-303322-d69o3z8d 94 21 diagnosis diagnosis NN cord-303322-d69o3z8d 94 22 is be VBZ cord-303322-d69o3z8d 94 23 used use VBN cord-303322-d69o3z8d 94 24 ( ( -LRB- cord-303322-d69o3z8d 94 25 tachypnoea tachypnoea NNP cord-303322-d69o3z8d 94 26 ( ( -LRB- cord-303322-d69o3z8d 94 27 respiratory respiratory JJ cord-303322-d69o3z8d 94 28 rate rate NN cord-303322-d69o3z8d 94 29 ≥60 ≥60 NNP cord-303322-d69o3z8d 94 30 / / SYM cord-303322-d69o3z8d 94 31 min min NN cord-303322-d69o3z8d 94 32 in in IN cord-303322-d69o3z8d 94 33 infants infant NNS cord-303322-d69o3z8d 94 34 aged age VBN cord-303322-d69o3z8d 95 1 < < XX cord-303322-d69o3z8d 95 2 2-months 2-months CD cord-303322-d69o3z8d 95 3 , , , cord-303322-d69o3z8d 95 4 ≥50 ≥50 NNP cord-303322-d69o3z8d 95 5 / / SYM cord-303322-d69o3z8d 95 6 min min NNP cord-303322-d69o3z8d 96 1 if if IN cord-303322-d69o3z8d 96 2 2 2 CD cord-303322-d69o3z8d 96 3 - - SYM cord-303322-d69o3z8d 96 4 12 12 CD cord-303322-d69o3z8d 96 5 months month NNS cord-303322-d69o3z8d 96 6 , , , cord-303322-d69o3z8d 96 7 and and CC cord-303322-d69o3z8d 96 8 > > XX cord-303322-d69o3z8d 96 9 40 40 CD cord-303322-d69o3z8d 96 10 / / SYM cord-303322-d69o3z8d 96 11 min min NN cord-303322-d69o3z8d 96 12 if if IN cord-303322-d69o3z8d 96 13 13 13 CD cord-303322-d69o3z8d 96 14 - - SYM cord-303322-d69o3z8d 96 15 24 24 CD cord-303322-d69o3z8d 96 16 months month NNS cord-303322-d69o3z8d 96 17 ) ) -RRB- cord-303322-d69o3z8d 96 18 , , , cord-303322-d69o3z8d 96 19 with with IN cord-303322-d69o3z8d 96 20 wheeze wheeze NN cord-303322-d69o3z8d 96 21 or or CC cord-303322-d69o3z8d 96 22 crackles crackle NNS cord-303322-d69o3z8d 96 23 ) ) -RRB- cord-303322-d69o3z8d 96 24 ; ; : cord-303322-d69o3z8d 96 25 [ [ -LRB- cord-303322-d69o3z8d 96 26 31 31 CD cord-303322-d69o3z8d 96 27 , , , cord-303322-d69o3z8d 96 28 32 32 CD cord-303322-d69o3z8d 96 29 ] ] -RRB- cord-303322-d69o3z8d 96 30 and and CC cord-303322-d69o3z8d 96 31 2 2 CD cord-303322-d69o3z8d 96 32 . . . cord-303322-d69o3z8d 97 1 Recruited recruit VBN cord-303322-d69o3z8d 97 2 and and CC cord-303322-d69o3z8d 97 3 consented consent VBN cord-303322-d69o3z8d 97 4 within within IN cord-303322-d69o3z8d 97 5 24-hours 24-hours CD cord-303322-d69o3z8d 97 6 of of IN cord-303322-d69o3z8d 97 7 presentation presentation NN cord-303322-d69o3z8d 97 8 to to IN cord-303322-d69o3z8d 97 9 the the DT cord-303322-d69o3z8d 97 10 hospital hospital NN cord-303322-d69o3z8d 97 11 for for IN cord-303322-d69o3z8d 97 12 the the DT cord-303322-d69o3z8d 97 13 illness illness NN cord-303322-d69o3z8d 97 14 . . . cord-303322-d69o3z8d 98 1 Exclusion exclusion NN cord-303322-d69o3z8d 98 2 criteria criterion NNS cord-303322-d69o3z8d 98 3 : : : cord-303322-d69o3z8d 98 4 admission admission NN cord-303322-d69o3z8d 98 5 into into IN cord-303322-d69o3z8d 98 6 intensive intensive JJ cord-303322-d69o3z8d 98 7 care care NN cord-303322-d69o3z8d 98 8 , , , cord-303322-d69o3z8d 98 9 macrolide macrolide NN cord-303322-d69o3z8d 98 10 therapy therapy NN cord-303322-d69o3z8d 98 11 contraindicated contraindicate VBN cord-303322-d69o3z8d 98 12 ( ( -LRB- cord-303322-d69o3z8d 98 13 e.g. e.g. IN cord-303322-d69o3z8d 98 14 liver liver NN cord-303322-d69o3z8d 98 15 dysfunction dysfunction NN cord-303322-d69o3z8d 98 16 , , , cord-303322-d69o3z8d 98 17 hypersensitivity hypersensitivity NN cord-303322-d69o3z8d 98 18 ) ) -RRB- cord-303322-d69o3z8d 98 19 , , , cord-303322-d69o3z8d 98 20 presence presence NN cord-303322-d69o3z8d 98 21 of of IN cord-303322-d69o3z8d 98 22 diarrhoea diarrhoea NN cord-303322-d69o3z8d 98 23 ( ( -LRB- cord-303322-d69o3z8d 98 24 stools stool NNS cord-303322-d69o3z8d 98 25 of of IN cord-303322-d69o3z8d 98 26 increased increase VBN cord-303322-d69o3z8d 98 27 watery watery JJ cord-303322-d69o3z8d 98 28 consistency consistency NN cord-303322-d69o3z8d 98 29 and and CC cord-303322-d69o3z8d 98 30 more more JJR cord-303322-d69o3z8d 98 31 than than IN cord-303322-d69o3z8d 98 32 two two CD cord-303322-d69o3z8d 98 33 stools stool NNS cord-303322-d69o3z8d 98 34 above above IN cord-303322-d69o3z8d 98 35 usual usual JJ cord-303322-d69o3z8d 98 36 stooling stooling NN cord-303322-d69o3z8d 98 37 frequency frequency NN cord-303322-d69o3z8d 98 38 ) ) -RRB- cord-303322-d69o3z8d 98 39 , , , cord-303322-d69o3z8d 98 40 received receive VBD cord-303322-d69o3z8d 98 41 macrolides macrolide NNS cord-303322-d69o3z8d 98 42 ( ( -LRB- cord-303322-d69o3z8d 98 43 in in IN cord-303322-d69o3z8d 98 44 last last JJ cord-303322-d69o3z8d 98 45 7-days 7-days CD cord-303322-d69o3z8d 98 46 ) ) -RRB- cord-303322-d69o3z8d 98 47 , , , cord-303322-d69o3z8d 98 48 or or CC cord-303322-d69o3z8d 98 49 clinical clinical JJ cord-303322-d69o3z8d 98 50 and and CC cord-303322-d69o3z8d 98 51 radiological radiological JJ cord-303322-d69o3z8d 98 52 features feature NNS cord-303322-d69o3z8d 98 53 consistent consistent JJ cord-303322-d69o3z8d 98 54 with with IN cord-303322-d69o3z8d 98 55 a a DT cord-303322-d69o3z8d 98 56 primary primary JJ cord-303322-d69o3z8d 98 57 diagnosis diagnosis NN cord-303322-d69o3z8d 98 58 of of IN cord-303322-d69o3z8d 98 59 pneumonia pneumonia NN cord-303322-d69o3z8d 98 60 , , , cord-303322-d69o3z8d 98 61 [ [ -LRB- cord-303322-d69o3z8d 98 62 33 33 CD cord-303322-d69o3z8d 98 63 ] ] -RRB- cord-303322-d69o3z8d 98 64 at at IN cord-303322-d69o3z8d 98 65 time time NN cord-303322-d69o3z8d 98 66 of of IN cord-303322-d69o3z8d 98 67 randomisation randomisation NN cord-303322-d69o3z8d 98 68 . . . cord-303322-d69o3z8d 99 1 At at IN cord-303322-d69o3z8d 99 2 each each DT cord-303322-d69o3z8d 99 3 site site NN cord-303322-d69o3z8d 99 4 , , , cord-303322-d69o3z8d 99 5 the the DT cord-303322-d69o3z8d 99 6 site site NN cord-303322-d69o3z8d 99 7 - - HYPH cord-303322-d69o3z8d 99 8 specific specific JJ cord-303322-d69o3z8d 99 9 study study NN cord-303322-d69o3z8d 99 10 nurse nurse NN cord-303322-d69o3z8d 99 11 visits visit VBZ cord-303322-d69o3z8d 99 12 the the DT cord-303322-d69o3z8d 99 13 wards ward NNS cord-303322-d69o3z8d 99 14 twice twice RB cord-303322-d69o3z8d 99 15 daily daily RB cord-303322-d69o3z8d 99 16 to to TO cord-303322-d69o3z8d 99 17 screen screen VB cord-303322-d69o3z8d 99 18 all all DT cord-303322-d69o3z8d 99 19 newly newly RB cord-303322-d69o3z8d 99 20 admitted admit VBN cord-303322-d69o3z8d 99 21 infants infant NNS cord-303322-d69o3z8d 99 22 . . . cord-303322-d69o3z8d 100 1 A a DT cord-303322-d69o3z8d 100 2 standardised standardised JJ cord-303322-d69o3z8d 100 3 collection collection NN cord-303322-d69o3z8d 100 4 form form NN cord-303322-d69o3z8d 100 5 is be VBZ cord-303322-d69o3z8d 100 6 used use VBN cord-303322-d69o3z8d 100 7 to to TO cord-303322-d69o3z8d 100 8 collect collect VB cord-303322-d69o3z8d 100 9 clinical clinical JJ cord-303322-d69o3z8d 100 10 data datum NNS cord-303322-d69o3z8d 100 11 ( ( -LRB- cord-303322-d69o3z8d 100 12 see see VB cord-303322-d69o3z8d 100 13 below below RB cord-303322-d69o3z8d 100 14 ) ) -RRB- cord-303322-d69o3z8d 100 15 and and CC cord-303322-d69o3z8d 100 16 hospital hospital NN cord-303322-d69o3z8d 100 17 outcomes outcome NNS cord-303322-d69o3z8d 100 18 associated associate VBN cord-303322-d69o3z8d 100 19 with with IN cord-303322-d69o3z8d 100 20 the the DT cord-303322-d69o3z8d 100 21 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 100 22 episode episode NN cord-303322-d69o3z8d 100 23 . . . cord-303322-d69o3z8d 101 1 All all DT cord-303322-d69o3z8d 101 2 infants infant NNS cord-303322-d69o3z8d 101 3 are be VBP cord-303322-d69o3z8d 101 4 managed manage VBN cord-303322-d69o3z8d 101 5 according accord VBG cord-303322-d69o3z8d 101 6 to to IN cord-303322-d69o3z8d 101 7 a a DT cord-303322-d69o3z8d 101 8 standardised standardised JJ cord-303322-d69o3z8d 101 9 protocol protocol NN cord-303322-d69o3z8d 101 10 . . . cord-303322-d69o3z8d 102 1 This this DT cord-303322-d69o3z8d 102 2 has have VBZ cord-303322-d69o3z8d 102 3 been be VBN cord-303322-d69o3z8d 102 4 used use VBN cord-303322-d69o3z8d 102 5 at at IN cord-303322-d69o3z8d 102 6 the the DT cord-303322-d69o3z8d 102 7 Royal Royal NNP cord-303322-d69o3z8d 102 8 Darwin Darwin NNP cord-303322-d69o3z8d 102 9 Hospital Hospital NNP cord-303322-d69o3z8d 102 10 since since IN cord-303322-d69o3z8d 102 11 2008 2008 CD cord-303322-d69o3z8d 102 12 . . . cord-303322-d69o3z8d 103 1 The the DT cord-303322-d69o3z8d 103 2 protocol protocol NN cord-303322-d69o3z8d 103 3 outlines outline VBZ cord-303322-d69o3z8d 103 4 when when WRB cord-303322-d69o3z8d 103 5 supplementary supplementary JJ cord-303322-d69o3z8d 103 6 oxygen oxygen NN cord-303322-d69o3z8d 103 7 is be VBZ cord-303322-d69o3z8d 103 8 prescribed prescribe VBN cord-303322-d69o3z8d 103 9 ( ( -LRB- cord-303322-d69o3z8d 103 10 Sp0 sp0 NN cord-303322-d69o3z8d 103 11 2 2 CD cord-303322-d69o3z8d 103 12 < < XX cord-303322-d69o3z8d 103 13 94 94 CD cord-303322-d69o3z8d 103 14 % % NN cord-303322-d69o3z8d 103 15 ) ) -RRB- cord-303322-d69o3z8d 103 16 and and CC cord-303322-d69o3z8d 103 17 reduced reduce VBN cord-303322-d69o3z8d 103 18 , , , cord-303322-d69o3z8d 103 19 and and CC cord-303322-d69o3z8d 103 20 when when WRB cord-303322-d69o3z8d 103 21 nasogastric nasogastric NN cord-303322-d69o3z8d 103 22 feeds feed VBZ cord-303322-d69o3z8d 103 23 or or CC cord-303322-d69o3z8d 103 24 intravenous intravenous JJ cord-303322-d69o3z8d 103 25 fluids fluid NNS cord-303322-d69o3z8d 103 26 are be VBP cord-303322-d69o3z8d 103 27 used use VBN cord-303322-d69o3z8d 103 28 . . . cord-303322-d69o3z8d 104 1 Enrolled enrol VBN cord-303322-d69o3z8d 104 2 infants infant NNS cord-303322-d69o3z8d 104 3 may may MD cord-303322-d69o3z8d 104 4 receive receive VB cord-303322-d69o3z8d 104 5 additional additional JJ cord-303322-d69o3z8d 104 6 therapies therapy NNS cord-303322-d69o3z8d 104 7 ( ( -LRB- cord-303322-d69o3z8d 104 8 other other JJ cord-303322-d69o3z8d 104 9 than than IN cord-303322-d69o3z8d 104 10 macrolides macrolide NNS cord-303322-d69o3z8d 104 11 ) ) -RRB- cord-303322-d69o3z8d 104 12 at at IN cord-303322-d69o3z8d 104 13 the the DT cord-303322-d69o3z8d 104 14 discretion discretion NN cord-303322-d69o3z8d 104 15 of of IN cord-303322-d69o3z8d 104 16 the the DT cord-303322-d69o3z8d 104 17 attending attend VBG cord-303322-d69o3z8d 104 18 paediatrician paediatrician NN cord-303322-d69o3z8d 104 19 . . . cord-303322-d69o3z8d 105 1 If if IN cord-303322-d69o3z8d 105 2 eligibility eligibility NN cord-303322-d69o3z8d 105 3 is be VBZ cord-303322-d69o3z8d 105 4 fulfilled fulfil VBN cord-303322-d69o3z8d 105 5 and and CC cord-303322-d69o3z8d 105 6 after after IN cord-303322-d69o3z8d 105 7 informed informed JJ cord-303322-d69o3z8d 105 8 consent consent NN cord-303322-d69o3z8d 105 9 has have VBZ cord-303322-d69o3z8d 105 10 been be VBN cord-303322-d69o3z8d 105 11 obtained obtain VBN cord-303322-d69o3z8d 105 12 , , , cord-303322-d69o3z8d 105 13 the the DT cord-303322-d69o3z8d 105 14 infant infant NN cord-303322-d69o3z8d 105 15 is be VBZ cord-303322-d69o3z8d 105 16 randomised randomised JJ cord-303322-d69o3z8d 105 17 to to TO cord-303322-d69o3z8d 105 18 receive receive VB cord-303322-d69o3z8d 105 19 either either CC cord-303322-d69o3z8d 105 20 a a DT cord-303322-d69o3z8d 105 21 single single JJ cord-303322-d69o3z8d 105 22 , , , cord-303322-d69o3z8d 105 23 oral oral JJ cord-303322-d69o3z8d 105 24 liquid liquid NN cord-303322-d69o3z8d 105 25 dose dose NN cord-303322-d69o3z8d 105 26 of of IN cord-303322-d69o3z8d 105 27 azithromycin azithromycin NNP cord-303322-d69o3z8d 105 28 syrup syrup NN cord-303322-d69o3z8d 105 29 ( ( -LRB- cord-303322-d69o3z8d 105 30 30 30 CD cord-303322-d69o3z8d 105 31 mg mg NN cord-303322-d69o3z8d 105 32 per per IN cord-303322-d69o3z8d 105 33 kg kg NN cord-303322-d69o3z8d 105 34 ) ) -RRB- cord-303322-d69o3z8d 105 35 or or CC cord-303322-d69o3z8d 105 36 an an DT cord-303322-d69o3z8d 105 37 equivalent equivalent JJ cord-303322-d69o3z8d 105 38 volume volume NN cord-303322-d69o3z8d 105 39 of of IN cord-303322-d69o3z8d 105 40 placebo placebo NN cord-303322-d69o3z8d 105 41 . . . cord-303322-d69o3z8d 106 1 Medication medication NN cord-303322-d69o3z8d 106 2 is be VBZ cord-303322-d69o3z8d 106 3 given give VBN cord-303322-d69o3z8d 106 4 within within IN cord-303322-d69o3z8d 106 5 24-hours 24-hours CD cord-303322-d69o3z8d 106 6 of of IN cord-303322-d69o3z8d 106 7 hospitalisation hospitalisation NN cord-303322-d69o3z8d 106 8 . . . cord-303322-d69o3z8d 107 1 Infants infant NNS cord-303322-d69o3z8d 107 2 randomised randomised JJ cord-303322-d69o3z8d 107 3 to to IN cord-303322-d69o3z8d 107 4 the the DT cord-303322-d69o3z8d 107 5 intervention intervention NN cord-303322-d69o3z8d 107 6 arm arm NN cord-303322-d69o3z8d 107 7 of of IN cord-303322-d69o3z8d 107 8 the the DT cord-303322-d69o3z8d 107 9 study study NN cord-303322-d69o3z8d 107 10 will will MD cord-303322-d69o3z8d 107 11 receive receive VB cord-303322-d69o3z8d 107 12 additional additional JJ cord-303322-d69o3z8d 107 13 treatment treatment NN cord-303322-d69o3z8d 107 14 doses dose NNS cord-303322-d69o3z8d 107 15 of of IN cord-303322-d69o3z8d 107 16 azithromycin azithromycin NNP cord-303322-d69o3z8d 107 17 syrup syrup NN cord-303322-d69o3z8d 107 18 ( ( -LRB- cord-303322-d69o3z8d 107 19 30 30 CD cord-303322-d69o3z8d 107 20 mg mg NN cord-303322-d69o3z8d 107 21 per per IN cord-303322-d69o3z8d 107 22 kg kg NNP cord-303322-d69o3z8d 107 23 ) ) -RRB- cord-303322-d69o3z8d 107 24 on on IN cord-303322-d69o3z8d 107 25 day-7 day-7 NNP cord-303322-d69o3z8d 107 26 and and CC cord-303322-d69o3z8d 107 27 day-14 day-14 NNP cord-303322-d69o3z8d 107 28 . . . cord-303322-d69o3z8d 108 1 Those those DT cord-303322-d69o3z8d 108 2 randomised randomised JJ cord-303322-d69o3z8d 108 3 to to IN cord-303322-d69o3z8d 108 4 the the DT cord-303322-d69o3z8d 108 5 control control NN cord-303322-d69o3z8d 108 6 arm arm NN cord-303322-d69o3z8d 108 7 receive receive VB cord-303322-d69o3z8d 108 8 an an DT cord-303322-d69o3z8d 108 9 equivalent equivalent JJ cord-303322-d69o3z8d 108 10 volume volume NN cord-303322-d69o3z8d 108 11 of of IN cord-303322-d69o3z8d 108 12 the the DT cord-303322-d69o3z8d 108 13 placebo placebo NN cord-303322-d69o3z8d 108 14 syrup syrup NN cord-303322-d69o3z8d 108 15 . . . cord-303322-d69o3z8d 109 1 The the DT cord-303322-d69o3z8d 109 2 later later JJ cord-303322-d69o3z8d 109 3 doses dose NNS cord-303322-d69o3z8d 109 4 will will MD cord-303322-d69o3z8d 109 5 be be VB cord-303322-d69o3z8d 109 6 either either RB cord-303322-d69o3z8d 109 7 supervised supervise VBN cord-303322-d69o3z8d 109 8 by by IN cord-303322-d69o3z8d 109 9 study study NN cord-303322-d69o3z8d 109 10 nurses nurse NNS cord-303322-d69o3z8d 109 11 or or CC cord-303322-d69o3z8d 109 12 administered administer VBN cord-303322-d69o3z8d 109 13 by by IN cord-303322-d69o3z8d 109 14 families family NNS cord-303322-d69o3z8d 109 15 with with IN cord-303322-d69o3z8d 109 16 phone phone NN cord-303322-d69o3z8d 109 17 support support NN cord-303322-d69o3z8d 109 18 on on IN cord-303322-d69o3z8d 109 19 the the DT cord-303322-d69o3z8d 109 20 day day NN cord-303322-d69o3z8d 109 21 the the DT cord-303322-d69o3z8d 109 22 medication medication NN cord-303322-d69o3z8d 109 23 is be VBZ cord-303322-d69o3z8d 109 24 due due JJ cord-303322-d69o3z8d 109 25 . . . cord-303322-d69o3z8d 110 1 Final final JJ cord-303322-d69o3z8d 110 2 clinical clinical JJ cord-303322-d69o3z8d 110 3 follow follow NN cord-303322-d69o3z8d 110 4 up up RP cord-303322-d69o3z8d 110 5 will will MD cord-303322-d69o3z8d 110 6 occur occur VB cord-303322-d69o3z8d 110 7 in in IN cord-303322-d69o3z8d 110 8 the the DT cord-303322-d69o3z8d 110 9 local local JJ cord-303322-d69o3z8d 110 10 health health NN cord-303322-d69o3z8d 110 11 clinic clinic NN cord-303322-d69o3z8d 110 12 on on IN cord-303322-d69o3z8d 110 13 day-21 day-21 NNP cord-303322-d69o3z8d 110 14 ( ( -LRB- cord-303322-d69o3z8d 110 15 or or CC cord-303322-d69o3z8d 110 16 closest close JJS cord-303322-d69o3z8d 110 17 available available JJ cord-303322-d69o3z8d 110 18 date date NN cord-303322-d69o3z8d 110 19 from from IN cord-303322-d69o3z8d 110 20 day day NN cord-303322-d69o3z8d 110 21 20 20 CD cord-303322-d69o3z8d 110 22 to to TO cord-303322-d69o3z8d 110 23 24 24 CD cord-303322-d69o3z8d 110 24 ) ) -RRB- cord-303322-d69o3z8d 110 25 . . . cord-303322-d69o3z8d 111 1 The the DT cord-303322-d69o3z8d 111 2 randomisation randomisation NN cord-303322-d69o3z8d 111 3 sequence sequence NN cord-303322-d69o3z8d 111 4 was be VBD cord-303322-d69o3z8d 111 5 computer computer NN cord-303322-d69o3z8d 111 6 generated generate VBN cord-303322-d69o3z8d 111 7 and and CC cord-303322-d69o3z8d 111 8 used use VBD cord-303322-d69o3z8d 111 9 permutated permutate VBN cord-303322-d69o3z8d 111 10 blocks block NNS cord-303322-d69o3z8d 111 11 ( ( -LRB- cord-303322-d69o3z8d 111 12 4 4 CD cord-303322-d69o3z8d 111 13 or or CC cord-303322-d69o3z8d 111 14 6 6 CD cord-303322-d69o3z8d 111 15 participants participant NNS cord-303322-d69o3z8d 111 16 per per IN cord-303322-d69o3z8d 111 17 block block NN cord-303322-d69o3z8d 111 18 ) ) -RRB- cord-303322-d69o3z8d 111 19 . . . cord-303322-d69o3z8d 112 1 The the DT cord-303322-d69o3z8d 112 2 allocation allocation NN cord-303322-d69o3z8d 112 3 sequence sequence NN cord-303322-d69o3z8d 112 4 is be VBZ cord-303322-d69o3z8d 112 5 concealed conceal VBN cord-303322-d69o3z8d 112 6 at at IN cord-303322-d69o3z8d 112 7 all all DT cord-303322-d69o3z8d 112 8 times time NNS cord-303322-d69o3z8d 112 9 throughout throughout IN cord-303322-d69o3z8d 112 10 the the DT cord-303322-d69o3z8d 112 11 study study NN cord-303322-d69o3z8d 112 12 . . . cord-303322-d69o3z8d 113 1 The the DT cord-303322-d69o3z8d 113 2 computer computer NN cord-303322-d69o3z8d 113 3 generation generation NN cord-303322-d69o3z8d 113 4 and and CC cord-303322-d69o3z8d 113 5 allocation allocation NN cord-303322-d69o3z8d 113 6 were be VBD cord-303322-d69o3z8d 113 7 performed perform VBN cord-303322-d69o3z8d 113 8 by by IN cord-303322-d69o3z8d 113 9 a a DT cord-303322-d69o3z8d 113 10 statistician statistician NN cord-303322-d69o3z8d 113 11 , , , cord-303322-d69o3z8d 113 12 external external JJ cord-303322-d69o3z8d 113 13 to to IN cord-303322-d69o3z8d 113 14 the the DT cord-303322-d69o3z8d 113 15 study study NN cord-303322-d69o3z8d 113 16 team team NN cord-303322-d69o3z8d 113 17 . . . cord-303322-d69o3z8d 114 1 Upon upon IN cord-303322-d69o3z8d 114 2 enrolment enrolment NN cord-303322-d69o3z8d 114 3 , , , cord-303322-d69o3z8d 114 4 an an DT cord-303322-d69o3z8d 114 5 infant infant NN cord-303322-d69o3z8d 114 6 is be VBZ cord-303322-d69o3z8d 114 7 assigned assign VBN cord-303322-d69o3z8d 114 8 to to IN cord-303322-d69o3z8d 114 9 the the DT cord-303322-d69o3z8d 114 10 next next JJ cord-303322-d69o3z8d 114 11 number number NN cord-303322-d69o3z8d 114 12 on on IN cord-303322-d69o3z8d 114 13 the the DT cord-303322-d69o3z8d 114 14 appropriate appropriate JJ cord-303322-d69o3z8d 114 15 stratified stratified JJ cord-303322-d69o3z8d 114 16 list list NN cord-303322-d69o3z8d 114 17 . . . cord-303322-d69o3z8d 115 1 Each each DT cord-303322-d69o3z8d 115 2 unique unique JJ cord-303322-d69o3z8d 115 3 number number NN cord-303322-d69o3z8d 115 4 is be VBZ cord-303322-d69o3z8d 115 5 assigned assign VBN cord-303322-d69o3z8d 115 6 to to IN cord-303322-d69o3z8d 115 7 one one CD cord-303322-d69o3z8d 115 8 of of IN cord-303322-d69o3z8d 115 9 the the DT cord-303322-d69o3z8d 115 10 eight eight CD cord-303322-d69o3z8d 115 11 treatment treatment NN cord-303322-d69o3z8d 115 12 alphabets alphabet NNS cord-303322-d69o3z8d 115 13 ( ( -LRB- cord-303322-d69o3z8d 115 14 see see VB cord-303322-d69o3z8d 115 15 below below RB cord-303322-d69o3z8d 115 16 ) ) -RRB- cord-303322-d69o3z8d 115 17 . . . cord-303322-d69o3z8d 116 1 Treatment treatment NN cord-303322-d69o3z8d 116 2 groups group NNS cord-303322-d69o3z8d 116 3 are be VBP cord-303322-d69o3z8d 116 4 stratified stratify VBN cord-303322-d69o3z8d 116 5 by by IN cord-303322-d69o3z8d 116 6 age age NN cord-303322-d69o3z8d 116 7 ( ( -LRB- cord-303322-d69o3z8d 116 8 ≤6 ≤6 NNS cord-303322-d69o3z8d 116 9 or or CC cord-303322-d69o3z8d 116 10 > > XX cord-303322-d69o3z8d 116 11 6 6 CD cord-303322-d69o3z8d 116 12 months month NNS cord-303322-d69o3z8d 116 13 ) ) -RRB- cord-303322-d69o3z8d 116 14 , , , cord-303322-d69o3z8d 116 15 site site NN cord-303322-d69o3z8d 116 16 ( ( -LRB- cord-303322-d69o3z8d 116 17 Darwin Darwin NNP cord-303322-d69o3z8d 116 18 or or CC cord-303322-d69o3z8d 116 19 Townsville Townsville NNP cord-303322-d69o3z8d 116 20 ) ) -RRB- cord-303322-d69o3z8d 116 21 and and CC cord-303322-d69o3z8d 116 22 requirement requirement NN cord-303322-d69o3z8d 116 23 ( ( -LRB- cord-303322-d69o3z8d 116 24 yes yes UH cord-303322-d69o3z8d 116 25 or or CC cord-303322-d69o3z8d 116 26 no no UH cord-303322-d69o3z8d 116 27 ) ) -RRB- cord-303322-d69o3z8d 116 28 for for IN cord-303322-d69o3z8d 116 29 oxygen oxygen NN cord-303322-d69o3z8d 116 30 at at IN cord-303322-d69o3z8d 116 31 point point NN cord-303322-d69o3z8d 116 32 of of IN cord-303322-d69o3z8d 116 33 randomisation randomisation NN cord-303322-d69o3z8d 116 34 . . . cord-303322-d69o3z8d 117 1 The the DT cord-303322-d69o3z8d 117 2 importance importance NN cord-303322-d69o3z8d 117 3 of of IN cord-303322-d69o3z8d 117 4 excluding exclude VBG cord-303322-d69o3z8d 117 5 older old JJR cord-303322-d69o3z8d 117 6 children child NNS cord-303322-d69o3z8d 117 7 and and CC cord-303322-d69o3z8d 117 8 stratifying stratify VBG cord-303322-d69o3z8d 117 9 at at IN cord-303322-d69o3z8d 117 10 the the DT cord-303322-d69o3z8d 117 11 6 6 CD cord-303322-d69o3z8d 117 12 month month NN cord-303322-d69o3z8d 117 13 age age NN cord-303322-d69o3z8d 117 14 group group NN cord-303322-d69o3z8d 117 15 is be VBZ cord-303322-d69o3z8d 117 16 well well RB cord-303322-d69o3z8d 117 17 described describe VBN cord-303322-d69o3z8d 117 18 [ [ -LRB- cord-303322-d69o3z8d 117 19 30 30 CD cord-303322-d69o3z8d 117 20 , , , cord-303322-d69o3z8d 117 21 34 34 CD cord-303322-d69o3z8d 117 22 ] ] -RRB- cord-303322-d69o3z8d 117 23 . . . cord-303322-d69o3z8d 118 1 A a DT cord-303322-d69o3z8d 118 2 placebo placebo NN cord-303322-d69o3z8d 118 3 medication medication NN cord-303322-d69o3z8d 118 4 ensures ensure VBZ cord-303322-d69o3z8d 118 5 that that IN cord-303322-d69o3z8d 118 6 all all DT cord-303322-d69o3z8d 118 7 children child NNS cord-303322-d69o3z8d 118 8 , , , cord-303322-d69o3z8d 118 9 carers carer NNS cord-303322-d69o3z8d 118 10 , , , cord-303322-d69o3z8d 118 11 researchers researcher NNS cord-303322-d69o3z8d 118 12 , , , cord-303322-d69o3z8d 118 13 hospital hospital NN cord-303322-d69o3z8d 118 14 staff staff NN cord-303322-d69o3z8d 118 15 , , , cord-303322-d69o3z8d 118 16 and and CC cord-303322-d69o3z8d 118 17 clinic clinic NN cord-303322-d69o3z8d 118 18 staff staff NN cord-303322-d69o3z8d 118 19 are be VBP cord-303322-d69o3z8d 118 20 blinded blind VBN cord-303322-d69o3z8d 118 21 to to IN cord-303322-d69o3z8d 118 22 treatment treatment NN cord-303322-d69o3z8d 118 23 group group NN cord-303322-d69o3z8d 118 24 until until IN cord-303322-d69o3z8d 118 25 analyses analysis NNS cord-303322-d69o3z8d 118 26 of of IN cord-303322-d69o3z8d 118 27 the the DT cord-303322-d69o3z8d 118 28 data datum NNS cord-303322-d69o3z8d 118 29 . . . cord-303322-d69o3z8d 119 1 The the DT cord-303322-d69o3z8d 119 2 placebo placebo NN cord-303322-d69o3z8d 119 3 medication medication NN cord-303322-d69o3z8d 119 4 has have VBZ cord-303322-d69o3z8d 119 5 been be VBN cord-303322-d69o3z8d 119 6 specifically specifically RB cord-303322-d69o3z8d 119 7 manufactured manufacture VBN cord-303322-d69o3z8d 119 8 by by IN cord-303322-d69o3z8d 119 9 the the DT cord-303322-d69o3z8d 119 10 Institute Institute NNP cord-303322-d69o3z8d 119 11 of of IN cord-303322-d69o3z8d 119 12 Drug Drug NNP cord-303322-d69o3z8d 119 13 Technology Technology NNP cord-303322-d69o3z8d 119 14 ( ( -LRB- cord-303322-d69o3z8d 119 15 IDT IDT NNP cord-303322-d69o3z8d 119 16 ) ) -RRB- cord-303322-d69o3z8d 120 1 Australia Australia NNP cord-303322-d69o3z8d 120 2 Limited Limited NNP cord-303322-d69o3z8d 120 3 ( ( -LRB- cord-303322-d69o3z8d 120 4 Melbourne Melbourne NNP cord-303322-d69o3z8d 120 5 , , , cord-303322-d69o3z8d 120 6 Vic Vic NNP cord-303322-d69o3z8d 120 7 ) ) -RRB- cord-303322-d69o3z8d 120 8 which which WDT cord-303322-d69o3z8d 120 9 has have VBZ cord-303322-d69o3z8d 120 10 a a DT cord-303322-d69o3z8d 120 11 similar similar JJ cord-303322-d69o3z8d 120 12 taste taste NN cord-303322-d69o3z8d 120 13 and and CC cord-303322-d69o3z8d 120 14 colour colour NN cord-303322-d69o3z8d 120 15 to to IN cord-303322-d69o3z8d 120 16 azithromycin azithromycin NNP cord-303322-d69o3z8d 120 17 . . . cord-303322-d69o3z8d 121 1 The the DT cord-303322-d69o3z8d 121 2 azithromycin azithromycin NNP cord-303322-d69o3z8d 121 3 medications medication NNS cord-303322-d69o3z8d 121 4 were be VBD cord-303322-d69o3z8d 121 5 repackaged repackage VBN cord-303322-d69o3z8d 121 6 by by IN cord-303322-d69o3z8d 121 7 IDT IDT NNP cord-303322-d69o3z8d 121 8 . . . cord-303322-d69o3z8d 122 1 Thus thus RB cord-303322-d69o3z8d 122 2 both both DT cord-303322-d69o3z8d 122 3 the the DT cord-303322-d69o3z8d 122 4 azithromycin azithromycin NN cord-303322-d69o3z8d 122 5 and and CC cord-303322-d69o3z8d 122 6 placebo placebo NN cord-303322-d69o3z8d 122 7 are be VBP cord-303322-d69o3z8d 122 8 in in IN cord-303322-d69o3z8d 122 9 identical identical JJ cord-303322-d69o3z8d 122 10 opaque opaque JJ cord-303322-d69o3z8d 122 11 bottles bottle NNS cord-303322-d69o3z8d 122 12 and and CC cord-303322-d69o3z8d 122 13 sealed seal VBN cord-303322-d69o3z8d 122 14 with with IN cord-303322-d69o3z8d 122 15 an an DT cord-303322-d69o3z8d 122 16 aluminium aluminium NN cord-303322-d69o3z8d 122 17 foil foil NN cord-303322-d69o3z8d 122 18 . . . cord-303322-d69o3z8d 123 1 For for IN cord-303322-d69o3z8d 123 2 both both DT cord-303322-d69o3z8d 123 3 , , , cord-303322-d69o3z8d 123 4 equal equal JJ cord-303322-d69o3z8d 123 5 volumes volume NNS cord-303322-d69o3z8d 123 6 of of IN cord-303322-d69o3z8d 123 7 water water NN cord-303322-d69o3z8d 123 8 are be VBP cord-303322-d69o3z8d 123 9 added add VBN cord-303322-d69o3z8d 123 10 using use VBG cord-303322-d69o3z8d 123 11 a a DT cord-303322-d69o3z8d 123 12 syringe syringe NN cord-303322-d69o3z8d 123 13 and and CC cord-303322-d69o3z8d 123 14 needle needle NN cord-303322-d69o3z8d 123 15 by by IN cord-303322-d69o3z8d 123 16 punching punch VBG cord-303322-d69o3z8d 123 17 the the DT cord-303322-d69o3z8d 123 18 seal seal NN cord-303322-d69o3z8d 123 19 . . . cord-303322-d69o3z8d 124 1 Eight eight CD cord-303322-d69o3z8d 124 2 alphabets alphabet NNS cord-303322-d69o3z8d 124 3 ( ( -LRB- cord-303322-d69o3z8d 124 4 N n CC cord-303322-d69o3z8d 124 5 , , , cord-303322-d69o3z8d 124 6 O o UH cord-303322-d69o3z8d 124 7 , , , cord-303322-d69o3z8d 124 8 P p NN cord-303322-d69o3z8d 124 9 , , , cord-303322-d69o3z8d 124 10 Q Q NNP cord-303322-d69o3z8d 124 11 , , , cord-303322-d69o3z8d 124 12 R r NN cord-303322-d69o3z8d 124 13 , , , cord-303322-d69o3z8d 124 14 S S NNP cord-303322-d69o3z8d 124 15 , , , cord-303322-d69o3z8d 124 16 T T NNP cord-303322-d69o3z8d 124 17 , , , cord-303322-d69o3z8d 124 18 U U NNP cord-303322-d69o3z8d 124 19 ) ) -RRB- cord-303322-d69o3z8d 124 20 were be VBD cord-303322-d69o3z8d 124 21 used use VBN cord-303322-d69o3z8d 124 22 for for IN cord-303322-d69o3z8d 124 23 the the DT cord-303322-d69o3z8d 124 24 bottles bottle NNS cord-303322-d69o3z8d 124 25 of of IN cord-303322-d69o3z8d 124 26 azithromycin azithromycin NN cord-303322-d69o3z8d 124 27 and and CC cord-303322-d69o3z8d 124 28 placebo placebo NN cord-303322-d69o3z8d 124 29 medications medication NNS cord-303322-d69o3z8d 124 30 ( ( -LRB- cord-303322-d69o3z8d 124 31 4 4 CD cord-303322-d69o3z8d 124 32 alphabets alphabet NNS cord-303322-d69o3z8d 124 33 each each DT cord-303322-d69o3z8d 124 34 ) ) -RRB- cord-303322-d69o3z8d 124 35 . . . cord-303322-d69o3z8d 125 1 We -PRON- PRP cord-303322-d69o3z8d 125 2 used use VBD cord-303322-d69o3z8d 125 3 multiple multiple JJ cord-303322-d69o3z8d 125 4 alphabets alphabet NNS cord-303322-d69o3z8d 125 5 rather rather RB cord-303322-d69o3z8d 125 6 than than IN cord-303322-d69o3z8d 125 7 sequential sequential JJ cord-303322-d69o3z8d 125 8 numbers number NNS cord-303322-d69o3z8d 125 9 on on IN cord-303322-d69o3z8d 125 10 the the DT cord-303322-d69o3z8d 125 11 bottles bottle NNS cord-303322-d69o3z8d 125 12 to to TO cord-303322-d69o3z8d 125 13 allow allow VB cord-303322-d69o3z8d 125 14 storage storage NN cord-303322-d69o3z8d 125 15 of of IN cord-303322-d69o3z8d 125 16 extra extra JJ cord-303322-d69o3z8d 125 17 bottles bottle NNS cord-303322-d69o3z8d 125 18 of of IN cord-303322-d69o3z8d 125 19 trial trial NN cord-303322-d69o3z8d 125 20 medications medication NNS cord-303322-d69o3z8d 125 21 in in IN cord-303322-d69o3z8d 125 22 clinics clinic NNS cord-303322-d69o3z8d 125 23 for for IN cord-303322-d69o3z8d 125 24 the the DT cord-303322-d69o3z8d 125 25 day-7 day-7 JJ cord-303322-d69o3z8d 125 26 and and CC cord-303322-d69o3z8d 125 27 day-14 day-14 NNP cord-303322-d69o3z8d 125 28 doses dose NNS cord-303322-d69o3z8d 125 29 . . . cord-303322-d69o3z8d 126 1 This this DT cord-303322-d69o3z8d 126 2 was be VBD cord-303322-d69o3z8d 126 3 necessary necessary JJ cord-303322-d69o3z8d 126 4 in in IN cord-303322-d69o3z8d 126 5 the the DT cord-303322-d69o3z8d 126 6 context context NN cord-303322-d69o3z8d 126 7 of of IN cord-303322-d69o3z8d 126 8 our -PRON- PRP$ cord-303322-d69o3z8d 126 9 study study NN cord-303322-d69o3z8d 126 10 setting set VBG cord-303322-d69o3z8d 126 11 ( ( -LRB- cord-303322-d69o3z8d 126 12 children child NNS cord-303322-d69o3z8d 126 13 mainly mainly RB cord-303322-d69o3z8d 126 14 from from IN cord-303322-d69o3z8d 126 15 remote remote JJ cord-303322-d69o3z8d 126 16 Indigenous indigenous JJ cord-303322-d69o3z8d 126 17 communities community NNS cord-303322-d69o3z8d 126 18 ) ) -RRB- cord-303322-d69o3z8d 126 19 , , , cord-303322-d69o3z8d 126 20 to to TO cord-303322-d69o3z8d 126 21 enhance enhance VB cord-303322-d69o3z8d 126 22 availability availability NN cord-303322-d69o3z8d 126 23 and and CC cord-303322-d69o3z8d 126 24 administration administration NN cord-303322-d69o3z8d 126 25 of of IN cord-303322-d69o3z8d 126 26 trial trial NN cord-303322-d69o3z8d 126 27 medications medication NNS cord-303322-d69o3z8d 126 28 once once IN cord-303322-d69o3z8d 126 29 the the DT cord-303322-d69o3z8d 126 30 child child NN cord-303322-d69o3z8d 126 31 has have VBZ cord-303322-d69o3z8d 126 32 been be VBN cord-303322-d69o3z8d 126 33 discharged discharge VBN cord-303322-d69o3z8d 126 34 from from IN cord-303322-d69o3z8d 126 35 the the DT cord-303322-d69o3z8d 126 36 hospital hospital NN cord-303322-d69o3z8d 126 37 . . . cord-303322-d69o3z8d 127 1 All all DT cord-303322-d69o3z8d 127 2 data datum NNS cord-303322-d69o3z8d 127 3 are be VBP cord-303322-d69o3z8d 127 4 recorded record VBN cord-303322-d69o3z8d 127 5 on on IN cord-303322-d69o3z8d 127 6 standardised standardised JJ cord-303322-d69o3z8d 127 7 forms form NNS cord-303322-d69o3z8d 127 8 . . . cord-303322-d69o3z8d 128 1 Demographic demographic JJ cord-303322-d69o3z8d 128 2 information information NN cord-303322-d69o3z8d 128 3 ( ( -LRB- cord-303322-d69o3z8d 128 4 age age NN cord-303322-d69o3z8d 128 5 , , , cord-303322-d69o3z8d 128 6 gender gender NN cord-303322-d69o3z8d 128 7 , , , cord-303322-d69o3z8d 128 8 region region NN cord-303322-d69o3z8d 128 9 , , , cord-303322-d69o3z8d 128 10 birth birth NN cord-303322-d69o3z8d 128 11 details detail NNS cord-303322-d69o3z8d 128 12 , , , cord-303322-d69o3z8d 128 13 smoke smoke NN cord-303322-d69o3z8d 128 14 exposure exposure NN cord-303322-d69o3z8d 128 15 , , , cord-303322-d69o3z8d 128 16 breast breast NN cord-303322-d69o3z8d 128 17 feeding feeding NN cord-303322-d69o3z8d 128 18 , , , cord-303322-d69o3z8d 128 19 household household NN cord-303322-d69o3z8d 128 20 size size NN cord-303322-d69o3z8d 128 21 , , , cord-303322-d69o3z8d 128 22 etc etc FW cord-303322-d69o3z8d 128 23 ) ) -RRB- cord-303322-d69o3z8d 128 24 and and CC cord-303322-d69o3z8d 128 25 medical medical JJ cord-303322-d69o3z8d 128 26 history history NN cord-303322-d69o3z8d 128 27 are be VBP cord-303322-d69o3z8d 128 28 obtained obtain VBN cord-303322-d69o3z8d 128 29 from from IN cord-303322-d69o3z8d 128 30 the the DT cord-303322-d69o3z8d 128 31 primary primary JJ cord-303322-d69o3z8d 128 32 caregiver caregiver NN cord-303322-d69o3z8d 128 33 and and CC cord-303322-d69o3z8d 128 34 the the DT cord-303322-d69o3z8d 128 35 medical medical JJ cord-303322-d69o3z8d 128 36 charts chart NNS cord-303322-d69o3z8d 128 37 . . . cord-303322-d69o3z8d 129 1 The the DT cord-303322-d69o3z8d 129 2 primary primary JJ cord-303322-d69o3z8d 129 3 and and CC cord-303322-d69o3z8d 129 4 secondary secondary JJ cord-303322-d69o3z8d 129 5 outcome outcome NN cord-303322-d69o3z8d 129 6 measures measure NNS cord-303322-d69o3z8d 129 7 ( ( -LRB- cord-303322-d69o3z8d 129 8 see see VB cord-303322-d69o3z8d 129 9 below below RB cord-303322-d69o3z8d 129 10 ) ) -RRB- cord-303322-d69o3z8d 129 11 are be VBP cord-303322-d69o3z8d 129 12 monitored monitor VBN cord-303322-d69o3z8d 129 13 twice twice RB cord-303322-d69o3z8d 129 14 daily daily RB cord-303322-d69o3z8d 129 15 until until IN cord-303322-d69o3z8d 129 16 the the DT cord-303322-d69o3z8d 129 17 hospital hospital NN cord-303322-d69o3z8d 129 18 admission admission NN cord-303322-d69o3z8d 129 19 's 's POS cord-303322-d69o3z8d 129 20 end end NN cord-303322-d69o3z8d 129 21 - - HYPH cord-303322-d69o3z8d 129 22 point point NN cord-303322-d69o3z8d 129 23 is be VBZ cord-303322-d69o3z8d 129 24 reached reach VBN cord-303322-d69o3z8d 129 25 ( ( -LRB- cord-303322-d69o3z8d 129 26 ready ready JJ cord-303322-d69o3z8d 129 27 for for IN cord-303322-d69o3z8d 129 28 respiratory respiratory JJ cord-303322-d69o3z8d 129 29 discharge discharge NN cord-303322-d69o3z8d 129 30 , , , cord-303322-d69o3z8d 129 31 defined define VBN cord-303322-d69o3z8d 129 32 as as IN cord-303322-d69o3z8d 129 33 > > XX cord-303322-d69o3z8d 129 34 16-hours 16-hours CD cord-303322-d69o3z8d 129 35 without without IN cord-303322-d69o3z8d 129 36 supplemental supplemental JJ cord-303322-d69o3z8d 129 37 oxygen oxygen NN cord-303322-d69o3z8d 129 38 and and CC cord-303322-d69o3z8d 129 39 infant infant NN cord-303322-d69o3z8d 129 40 is be VBZ cord-303322-d69o3z8d 129 41 feeding feed VBG cord-303322-d69o3z8d 129 42 well well RB cord-303322-d69o3z8d 129 43 ) ) -RRB- cord-303322-d69o3z8d 129 44 . . . cord-303322-d69o3z8d 130 1 Clinical clinical JJ cord-303322-d69o3z8d 130 2 assessment assessment NN cord-303322-d69o3z8d 130 3 data datum NNS cord-303322-d69o3z8d 130 4 include include VBP cord-303322-d69o3z8d 130 5 oxygen oxygen NN cord-303322-d69o3z8d 130 6 requirement requirement NN cord-303322-d69o3z8d 130 7 and and CC cord-303322-d69o3z8d 130 8 level level NN cord-303322-d69o3z8d 130 9 , , , cord-303322-d69o3z8d 130 10 physiological physiological JJ cord-303322-d69o3z8d 130 11 measurements measurement NNS cord-303322-d69o3z8d 130 12 for for IN cord-303322-d69o3z8d 130 13 clinical clinical JJ cord-303322-d69o3z8d 130 14 severity severity NN cord-303322-d69o3z8d 130 15 score score NN cord-303322-d69o3z8d 130 16 ( ( -LRB- cord-303322-d69o3z8d 130 17 respiratory respiratory JJ cord-303322-d69o3z8d 130 18 rate rate NN cord-303322-d69o3z8d 130 19 , , , cord-303322-d69o3z8d 130 20 accessory accessory JJ cord-303322-d69o3z8d 130 21 muscle muscle NN cord-303322-d69o3z8d 130 22 use use NN cord-303322-d69o3z8d 130 23 , , , cord-303322-d69o3z8d 130 24 degree degree NN cord-303322-d69o3z8d 130 25 of of IN cord-303322-d69o3z8d 130 26 wheeze wheeze NN cord-303322-d69o3z8d 130 27 ) ) -RRB- cord-303322-d69o3z8d 130 28 , , , cord-303322-d69o3z8d 130 29 [ [ -LRB- cord-303322-d69o3z8d 130 30 27 27 CD cord-303322-d69o3z8d 130 31 ] ] -RRB- cord-303322-d69o3z8d 130 32 other other JJ cord-303322-d69o3z8d 130 33 physiological physiological JJ cord-303322-d69o3z8d 130 34 measurement measurement NN cord-303322-d69o3z8d 130 35 ( ( -LRB- cord-303322-d69o3z8d 130 36 temperature temperature NN cord-303322-d69o3z8d 130 37 , , , cord-303322-d69o3z8d 130 38 heart heart NN cord-303322-d69o3z8d 130 39 rate rate NN cord-303322-d69o3z8d 130 40 ) ) -RRB- cord-303322-d69o3z8d 130 41 , , , cord-303322-d69o3z8d 130 42 requirement requirement NN cord-303322-d69o3z8d 130 43 and and CC cord-303322-d69o3z8d 130 44 duration duration NN cord-303322-d69o3z8d 130 45 of of IN cord-303322-d69o3z8d 130 46 other other JJ cord-303322-d69o3z8d 130 47 therapies therapy NNS cord-303322-d69o3z8d 130 48 required require VBN cord-303322-d69o3z8d 130 49 ( ( -LRB- cord-303322-d69o3z8d 130 50 intravenous intravenous JJ cord-303322-d69o3z8d 130 51 fluids fluid NNS cord-303322-d69o3z8d 130 52 , , , cord-303322-d69o3z8d 130 53 nutritional nutritional JJ cord-303322-d69o3z8d 130 54 support support NN cord-303322-d69o3z8d 130 55 , , , cord-303322-d69o3z8d 130 56 antibiotics antibiotic NNS cord-303322-d69o3z8d 130 57 ) ) -RRB- cord-303322-d69o3z8d 130 58 , , , cord-303322-d69o3z8d 130 59 ear ear NN cord-303322-d69o3z8d 130 60 examination examination NN cord-303322-d69o3z8d 130 61 findings finding NNS cord-303322-d69o3z8d 130 62 ( ( -LRB- cord-303322-d69o3z8d 130 63 signs sign NNS cord-303322-d69o3z8d 130 64 of of IN cord-303322-d69o3z8d 130 65 suppuration suppuration NN cord-303322-d69o3z8d 130 66 ) ) -RRB- cord-303322-d69o3z8d 130 67 and and CC cord-303322-d69o3z8d 130 68 subsequent subsequent JJ cord-303322-d69o3z8d 130 69 pneumonia pneumonia NN cord-303322-d69o3z8d 130 70 ( ( -LRB- cord-303322-d69o3z8d 130 71 diagnosed diagnose VBN cord-303322-d69o3z8d 130 72 by by IN cord-303322-d69o3z8d 130 73 the the DT cord-303322-d69o3z8d 130 74 independent independent JJ cord-303322-d69o3z8d 130 75 treating treat VBG cord-303322-d69o3z8d 130 76 ' ' `` cord-303322-d69o3z8d 130 77 blinded blinded JJ cord-303322-d69o3z8d 130 78 ' ' '' cord-303322-d69o3z8d 130 79 paediatrician paediatrician NN cord-303322-d69o3z8d 130 80 ) ) -RRB- cord-303322-d69o3z8d 130 81 . . . cord-303322-d69o3z8d 131 1 In in IN cord-303322-d69o3z8d 131 2 addition addition NN cord-303322-d69o3z8d 131 3 , , , cord-303322-d69o3z8d 131 4 the the DT cord-303322-d69o3z8d 131 5 results result NNS cord-303322-d69o3z8d 131 6 of of IN cord-303322-d69o3z8d 131 7 routine routine JJ cord-303322-d69o3z8d 131 8 investigations investigation NNS cord-303322-d69o3z8d 131 9 ( ( -LRB- cord-303322-d69o3z8d 131 10 full full JJ cord-303322-d69o3z8d 131 11 blood blood NN cord-303322-d69o3z8d 131 12 count count NN cord-303322-d69o3z8d 131 13 and and CC cord-303322-d69o3z8d 131 14 chest chest NN cord-303322-d69o3z8d 131 15 radiographic radiographic JJ cord-303322-d69o3z8d 131 16 findings finding NNS cord-303322-d69o3z8d 131 17 ) ) -RRB- cord-303322-d69o3z8d 131 18 are be VBP cord-303322-d69o3z8d 131 19 recorded record VBN cord-303322-d69o3z8d 131 20 . . . cord-303322-d69o3z8d 132 1 On on IN cord-303322-d69o3z8d 132 2 day-21 day-21 NNP cord-303322-d69o3z8d 132 3 , , , cord-303322-d69o3z8d 132 4 the the DT cord-303322-d69o3z8d 132 5 presence presence NN cord-303322-d69o3z8d 132 6 of of IN cord-303322-d69o3z8d 132 7 cough cough NN cord-303322-d69o3z8d 132 8 , , , cord-303322-d69o3z8d 132 9 wheeze wheeze VB cord-303322-d69o3z8d 132 10 and and CC cord-303322-d69o3z8d 132 11 auscultatory auscultatory RB cord-303322-d69o3z8d 132 12 abnormality abnormality NN cord-303322-d69o3z8d 132 13 on on IN cord-303322-d69o3z8d 132 14 clinical clinical JJ cord-303322-d69o3z8d 132 15 review review NN cord-303322-d69o3z8d 132 16 are be VBP cord-303322-d69o3z8d 132 17 documented document VBN cord-303322-d69o3z8d 132 18 . . . cord-303322-d69o3z8d 133 1 Adverse adverse JJ cord-303322-d69o3z8d 133 2 effects effect NNS cord-303322-d69o3z8d 133 3 ( ( -LRB- cord-303322-d69o3z8d 133 4 vomiting vomit VBG cord-303322-d69o3z8d 133 5 , , , cord-303322-d69o3z8d 133 6 diarrhoea diarrhoea NN cord-303322-d69o3z8d 133 7 , , , cord-303322-d69o3z8d 133 8 rash rash JJ cord-303322-d69o3z8d 133 9 ) ) -RRB- cord-303322-d69o3z8d 133 10 are be VBP cord-303322-d69o3z8d 133 11 also also RB cord-303322-d69o3z8d 133 12 documented document VBN cord-303322-d69o3z8d 133 13 . . . cord-303322-d69o3z8d 134 1 A a DT cord-303322-d69o3z8d 134 2 single single JJ cord-303322-d69o3z8d 134 3 nasopharyngeal nasopharyngeal JJ cord-303322-d69o3z8d 134 4 swab swab NN cord-303322-d69o3z8d 134 5 ( ( -LRB- cord-303322-d69o3z8d 134 6 NPS NPS NNP cord-303322-d69o3z8d 134 7 ) ) -RRB- cord-303322-d69o3z8d 134 8 specimen specimen NN cord-303322-d69o3z8d 134 9 for for IN cord-303322-d69o3z8d 134 10 respiratory respiratory JJ cord-303322-d69o3z8d 134 11 virus virus NN cord-303322-d69o3z8d 134 12 and and CC cord-303322-d69o3z8d 134 13 other other JJ cord-303322-d69o3z8d 134 14 potentially potentially RB cord-303322-d69o3z8d 134 15 important important JJ cord-303322-d69o3z8d 134 16 respiratory respiratory JJ cord-303322-d69o3z8d 134 17 pathogen pathogen NN cord-303322-d69o3z8d 134 18 ( ( -LRB- cord-303322-d69o3z8d 134 19 M. M. NNP cord-303322-d69o3z8d 134 20 pneumoniae pneumoniae NN cord-303322-d69o3z8d 134 21 , , , cord-303322-d69o3z8d 134 22 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 134 23 spp spp NNS cord-303322-d69o3z8d 134 24 ) ) -RRB- cord-303322-d69o3z8d 135 1 testing testing NN cord-303322-d69o3z8d 135 2 is be VBZ cord-303322-d69o3z8d 135 3 collected collect VBN cord-303322-d69o3z8d 135 4 from from IN cord-303322-d69o3z8d 135 5 each each DT cord-303322-d69o3z8d 135 6 subject subject NN cord-303322-d69o3z8d 135 7 at at IN cord-303322-d69o3z8d 135 8 enrolment enrolment NN cord-303322-d69o3z8d 135 9 . . . cord-303322-d69o3z8d 136 1 In in IN cord-303322-d69o3z8d 136 2 addition addition NN cord-303322-d69o3z8d 136 3 , , , cord-303322-d69o3z8d 136 4 NPS NPS NNP cord-303322-d69o3z8d 136 5 is be VBZ cord-303322-d69o3z8d 136 6 repeated repeat VBN cord-303322-d69o3z8d 136 7 before before IN cord-303322-d69o3z8d 136 8 hospital hospital NN cord-303322-d69o3z8d 136 9 discharge discharge NN cord-303322-d69o3z8d 136 10 for for IN cord-303322-d69o3z8d 136 11 bacterial bacterial JJ cord-303322-d69o3z8d 136 12 culture culture NN cord-303322-d69o3z8d 136 13 and and CC cord-303322-d69o3z8d 136 14 antibiotic antibiotic JJ cord-303322-d69o3z8d 136 15 susceptibility susceptibility NN cord-303322-d69o3z8d 136 16 testing testing NN cord-303322-d69o3z8d 136 17 , , , cord-303322-d69o3z8d 136 18 as as IN cord-303322-d69o3z8d 136 19 per per IN cord-303322-d69o3z8d 136 20 our -PRON- PRP$ cord-303322-d69o3z8d 136 21 laboratory laboratory NN cord-303322-d69o3z8d 136 22 research research NN cord-303322-d69o3z8d 136 23 protocol protocol NN cord-303322-d69o3z8d 136 24 ( ( -LRB- cord-303322-d69o3z8d 136 25 see see VB cord-303322-d69o3z8d 136 26 below below RB cord-303322-d69o3z8d 136 27 ) ) -RRB- cord-303322-d69o3z8d 136 28 [ [ -LRB- cord-303322-d69o3z8d 136 29 35 35 CD cord-303322-d69o3z8d 136 30 , , , cord-303322-d69o3z8d 136 31 36 36 CD cord-303322-d69o3z8d 136 32 ] ] -RRB- cord-303322-d69o3z8d 136 33 . . . cord-303322-d69o3z8d 137 1 Culturing culture VBG cord-303322-d69o3z8d 137 2 , , , cord-303322-d69o3z8d 137 3 identifying identify VBG cord-303322-d69o3z8d 137 4 and and CC cord-303322-d69o3z8d 137 5 serotyping serotype VBG cord-303322-d69o3z8d 137 6 common common JJ cord-303322-d69o3z8d 137 7 respiratory respiratory JJ cord-303322-d69o3z8d 137 8 bacteria bacteria NNS cord-303322-d69o3z8d 137 9 from from IN cord-303322-d69o3z8d 137 10 NPS NPS NNP cord-303322-d69o3z8d 137 11 is be VBZ cord-303322-d69o3z8d 137 12 an an DT cord-303322-d69o3z8d 137 13 established established JJ cord-303322-d69o3z8d 137 14 technique technique NN cord-303322-d69o3z8d 137 15 in in IN cord-303322-d69o3z8d 137 16 our -PRON- PRP$ cord-303322-d69o3z8d 137 17 laboratory laboratory NN cord-303322-d69o3z8d 137 18 at at IN cord-303322-d69o3z8d 137 19 Menzies Menzies NNP cord-303322-d69o3z8d 137 20 in in IN cord-303322-d69o3z8d 137 21 Darwin Darwin NNP cord-303322-d69o3z8d 137 22 [ [ -LRB- cord-303322-d69o3z8d 137 23 35 35 CD cord-303322-d69o3z8d 137 24 ] ] -RRB- cord-303322-d69o3z8d 137 25 . . . cord-303322-d69o3z8d 138 1 Swabs swab NNS cord-303322-d69o3z8d 138 2 are be VBP cord-303322-d69o3z8d 138 3 stored store VBN cord-303322-d69o3z8d 138 4 in in IN cord-303322-d69o3z8d 138 5 SMGGB SMGGB NNP cord-303322-d69o3z8d 138 6 at at IN cord-303322-d69o3z8d 138 7 -80 -80 NNP cord-303322-d69o3z8d 138 8 ° ° NN cord-303322-d69o3z8d 138 9 C C NNP cord-303322-d69o3z8d 138 10 before before IN cord-303322-d69o3z8d 138 11 being be VBG cord-303322-d69o3z8d 138 12 batch batch NN cord-303322-d69o3z8d 138 13 processed process VBN cord-303322-d69o3z8d 138 14 for for IN cord-303322-d69o3z8d 138 15 typical typical JJ cord-303322-d69o3z8d 138 16 respiratory respiratory JJ cord-303322-d69o3z8d 138 17 bacterial bacterial JJ cord-303322-d69o3z8d 138 18 pathogens pathogen NNS cord-303322-d69o3z8d 138 19 , , , cord-303322-d69o3z8d 138 20 notably notably RB cord-303322-d69o3z8d 138 21 H h NN cord-303322-d69o3z8d 138 22 influenzae influenzae NN cord-303322-d69o3z8d 138 23 and and CC cord-303322-d69o3z8d 138 24 non non JJ cord-303322-d69o3z8d 138 25 - - JJ cord-303322-d69o3z8d 138 26 typeable typeable JJ cord-303322-d69o3z8d 138 27 H h NN cord-303322-d69o3z8d 138 28 influenzae influenzae NN cord-303322-d69o3z8d 138 29 , , , cord-303322-d69o3z8d 138 30 M. M. NNP cord-303322-d69o3z8d 138 31 catarrhalis catarrhalis NNP cord-303322-d69o3z8d 138 32 and and CC cord-303322-d69o3z8d 138 33 S. S. NNP cord-303322-d69o3z8d 138 34 pneumoniae pneumoniae NN cord-303322-d69o3z8d 138 35 . . . cord-303322-d69o3z8d 139 1 Batches batch NNS cord-303322-d69o3z8d 139 2 of of IN cord-303322-d69o3z8d 139 3 swabs swab NNS cord-303322-d69o3z8d 139 4 are be VBP cord-303322-d69o3z8d 139 5 thawed thaw VBN cord-303322-d69o3z8d 139 6 and and CC cord-303322-d69o3z8d 139 7 10 10 CD cord-303322-d69o3z8d 139 8 μL μl NN cord-303322-d69o3z8d 139 9 aliquots aliquot NNS cord-303322-d69o3z8d 139 10 cultured culture VBN cord-303322-d69o3z8d 139 11 overnight overnight RB cord-303322-d69o3z8d 139 12 on on IN cord-303322-d69o3z8d 139 13 selective selective JJ cord-303322-d69o3z8d 139 14 media medium NNS cord-303322-d69o3z8d 139 15 at at IN cord-303322-d69o3z8d 139 16 37 37 CD cord-303322-d69o3z8d 139 17 ° ° NN cord-303322-d69o3z8d 139 18 C c NN cord-303322-d69o3z8d 139 19 in in IN cord-303322-d69o3z8d 139 20 5 5 CD cord-303322-d69o3z8d 139 21 % % NN cord-303322-d69o3z8d 139 22 CO co NN cord-303322-d69o3z8d 139 23 2 2 CD cord-303322-d69o3z8d 139 24 . . . cord-303322-d69o3z8d 140 1 Growth growth NN cord-303322-d69o3z8d 140 2 of of IN cord-303322-d69o3z8d 140 3 S. S. NNP cord-303322-d69o3z8d 140 4 pneumoniae pneumoniae NN cord-303322-d69o3z8d 140 5 , , , cord-303322-d69o3z8d 140 6 H. H. NNP cord-303322-d69o3z8d 140 7 influenzae influenzae NN cord-303322-d69o3z8d 140 8 and and CC cord-303322-d69o3z8d 140 9 M. M. NNP cord-303322-d69o3z8d 140 10 catarrhalis catarrhalis NNP cord-303322-d69o3z8d 140 11 is be VBZ cord-303322-d69o3z8d 140 12 recorded record VBN cord-303322-d69o3z8d 140 13 and and CC cord-303322-d69o3z8d 140 14 confirmed confirm VBN cord-303322-d69o3z8d 140 15 . . . cord-303322-d69o3z8d 141 1 Four four CD cord-303322-d69o3z8d 141 2 isolates isolate VBZ cord-303322-d69o3z8d 141 3 each each DT cord-303322-d69o3z8d 141 4 of of IN cord-303322-d69o3z8d 141 5 S. S. NNP cord-303322-d69o3z8d 141 6 pneumoniae pneumoniae NN cord-303322-d69o3z8d 141 7 and and CC cord-303322-d69o3z8d 141 8 H. h. NN cord-303322-d69o3z8d 141 9 influenzae influenzae NN cord-303322-d69o3z8d 141 10 and and CC cord-303322-d69o3z8d 141 11 two two CD cord-303322-d69o3z8d 141 12 isolates isolate NNS cord-303322-d69o3z8d 141 13 of of IN cord-303322-d69o3z8d 141 14 M. M. NNP cord-303322-d69o3z8d 141 15 catarrhalis catarrhalis FW cord-303322-d69o3z8d 141 16 per per IN cord-303322-d69o3z8d 141 17 positive positive JJ cord-303322-d69o3z8d 141 18 swab swab NN cord-303322-d69o3z8d 141 19 are be VBP cord-303322-d69o3z8d 141 20 tested test VBN cord-303322-d69o3z8d 141 21 for for IN cord-303322-d69o3z8d 141 22 anti anti JJ cord-303322-d69o3z8d 141 23 - - JJ cord-303322-d69o3z8d 141 24 microbial microbial JJ cord-303322-d69o3z8d 141 25 resistance resistance NN cord-303322-d69o3z8d 141 26 and and CC cord-303322-d69o3z8d 141 27 stored store VBD cord-303322-d69o3z8d 141 28 [ [ -LRB- cord-303322-d69o3z8d 141 29 35 35 CD cord-303322-d69o3z8d 141 30 , , , cord-303322-d69o3z8d 141 31 37 37 CD cord-303322-d69o3z8d 141 32 ] ] -RRB- cord-303322-d69o3z8d 141 33 . . . cord-303322-d69o3z8d 142 1 S. S. NNP cord-303322-d69o3z8d 142 2 pneumoniae pneumoniae NN cord-303322-d69o3z8d 142 3 isolates isolate NNS cord-303322-d69o3z8d 142 4 are be VBP cord-303322-d69o3z8d 142 5 serotyped serotyped JJ cord-303322-d69o3z8d 142 6 using use VBG cord-303322-d69o3z8d 142 7 the the DT cord-303322-d69o3z8d 142 8 Quellung Quellung NNP cord-303322-d69o3z8d 142 9 method method NN cord-303322-d69o3z8d 142 10 ( ( -LRB- cord-303322-d69o3z8d 142 11 antisera antisera NN cord-303322-d69o3z8d 142 12 from from IN cord-303322-d69o3z8d 142 13 Statens Statens NNP cord-303322-d69o3z8d 142 14 Serum Serum NNP cord-303322-d69o3z8d 142 15 Institute Institute NNP cord-303322-d69o3z8d 142 16 , , , cord-303322-d69o3z8d 142 17 Denmark Denmark NNP cord-303322-d69o3z8d 142 18 ) ) -RRB- cord-303322-d69o3z8d 142 19 . . . cord-303322-d69o3z8d 143 1 In in IN cord-303322-d69o3z8d 143 2 addition addition NN cord-303322-d69o3z8d 143 3 to to IN cord-303322-d69o3z8d 143 4 routine routine JJ cord-303322-d69o3z8d 143 5 susceptibility susceptibility NN cord-303322-d69o3z8d 143 6 testing testing NN cord-303322-d69o3z8d 143 7 using use VBG cord-303322-d69o3z8d 143 8 the the DT cord-303322-d69o3z8d 143 9 calibrated calibrate VBN cord-303322-d69o3z8d 143 10 dichotomous dichotomous JJ cord-303322-d69o3z8d 143 11 susceptibility susceptibility NN cord-303322-d69o3z8d 143 12 ( ( -LRB- cord-303322-d69o3z8d 143 13 CDS CDS NNP cord-303322-d69o3z8d 143 14 ) ) -RRB- cord-303322-d69o3z8d 143 15 disc disc NN cord-303322-d69o3z8d 143 16 diffusion diffusion NN cord-303322-d69o3z8d 143 17 method method NN cord-303322-d69o3z8d 143 18 , , , cord-303322-d69o3z8d 143 19 azithromycin azithromycin NNP cord-303322-d69o3z8d 143 20 minimum minimum JJ cord-303322-d69o3z8d 143 21 inhibitory inhibitory JJ cord-303322-d69o3z8d 143 22 concentration concentration NN cord-303322-d69o3z8d 143 23 ( ( -LRB- cord-303322-d69o3z8d 143 24 MIC MIC NNP cord-303322-d69o3z8d 143 25 ) ) -RRB- cord-303322-d69o3z8d 143 26 will will MD cord-303322-d69o3z8d 143 27 be be VB cord-303322-d69o3z8d 143 28 determined determine VBN cord-303322-d69o3z8d 143 29 using use VBG cord-303322-d69o3z8d 143 30 Etest Etest NNP cord-303322-d69o3z8d 143 31 ( ( -LRB- cord-303322-d69o3z8d 143 32 AB AB NNP cord-303322-d69o3z8d 143 33 Biodisk Biodisk NNP cord-303322-d69o3z8d 143 34 , , , cord-303322-d69o3z8d 143 35 Sweden Sweden NNP cord-303322-d69o3z8d 143 36 ) ) -RRB- cord-303322-d69o3z8d 143 37 if if IN cord-303322-d69o3z8d 143 38 the the DT cord-303322-d69o3z8d 143 39 azithromycin azithromycin NNP cord-303322-d69o3z8d 143 40 disc disc NN cord-303322-d69o3z8d 143 41 annulus annulus NN cord-303322-d69o3z8d 143 42 is be VBZ cord-303322-d69o3z8d 143 43 less less JJR cord-303322-d69o3z8d 143 44 than than IN cord-303322-d69o3z8d 143 45 6 6 CD cord-303322-d69o3z8d 143 46 mm mm NNS cord-303322-d69o3z8d 143 47 . . . cord-303322-d69o3z8d 144 1 For for IN cord-303322-d69o3z8d 144 2 S. S. NNP cord-303322-d69o3z8d 144 3 pneumoniae pneumoniae NN cord-303322-d69o3z8d 144 4 , , , cord-303322-d69o3z8d 144 5 the the DT cord-303322-d69o3z8d 144 6 penicillin penicillin NN cord-303322-d69o3z8d 144 7 MIC MIC NNP cord-303322-d69o3z8d 144 8 is be VBZ cord-303322-d69o3z8d 144 9 determined determine VBN cord-303322-d69o3z8d 144 10 for for IN cord-303322-d69o3z8d 144 11 penicillin penicillin NN cord-303322-d69o3z8d 144 12 non non JJ cord-303322-d69o3z8d 144 13 - - JJ cord-303322-d69o3z8d 144 14 susceptible susceptible JJ cord-303322-d69o3z8d 144 15 isolates isolate NNS cord-303322-d69o3z8d 144 16 ( ( -LRB- cord-303322-d69o3z8d 144 17 oxacillin oxacillin NNP cord-303322-d69o3z8d 144 18 and/or and/or CC cord-303322-d69o3z8d 144 19 penicillin penicillin NN cord-303322-d69o3z8d 144 20 disc disc NN cord-303322-d69o3z8d 144 21 annulus annulus NN cord-303322-d69o3z8d 144 22 < < XX cord-303322-d69o3z8d 144 23 6 6 CD cord-303322-d69o3z8d 144 24 mm mm NNP cord-303322-d69o3z8d 144 25 ) ) -RRB- cord-303322-d69o3z8d 144 26 and and CC cord-303322-d69o3z8d 144 27 for for IN cord-303322-d69o3z8d 144 28 H. H. NNP cord-303322-d69o3z8d 144 29 influenzae influenzae NN cord-303322-d69o3z8d 144 30 , , , cord-303322-d69o3z8d 144 31 the the DT cord-303322-d69o3z8d 144 32 ampicillin ampicillin NNP cord-303322-d69o3z8d 144 33 MIC MIC NNP cord-303322-d69o3z8d 144 34 is be VBZ cord-303322-d69o3z8d 144 35 determined determine VBN cord-303322-d69o3z8d 144 36 for for IN cord-303322-d69o3z8d 144 37 isolates isolate NNS cord-303322-d69o3z8d 144 38 if if IN cord-303322-d69o3z8d 145 1 the the DT cord-303322-d69o3z8d 145 2 ampicillin ampicillin NNP cord-303322-d69o3z8d 146 1 disc disc NN cord-303322-d69o3z8d 146 2 annulus annulus NN cord-303322-d69o3z8d 146 3 is be VBZ cord-303322-d69o3z8d 146 4 less less JJR cord-303322-d69o3z8d 146 5 than than IN cord-303322-d69o3z8d 146 6 6 6 CD cord-303322-d69o3z8d 146 7 mm mm NNS cord-303322-d69o3z8d 146 8 . . . cord-303322-d69o3z8d 147 1 Interpretive interpretive JJ cord-303322-d69o3z8d 147 2 criteria criterion NNS cord-303322-d69o3z8d 147 3 ( ( -LRB- cord-303322-d69o3z8d 147 4 CSLI CSLI NNP cord-303322-d69o3z8d 147 5 breakpoints breakpoint NNS cord-303322-d69o3z8d 147 6 ) ) -RRB- cord-303322-d69o3z8d 147 7 used use VBN cord-303322-d69o3z8d 147 8 for for IN cord-303322-d69o3z8d 147 9 S. S. NNP cord-303322-d69o3z8d 147 10 pneumoniae pneumoniae NN cord-303322-d69o3z8d 148 1 are be VBP cord-303322-d69o3z8d 148 2 penicillin penicillin NN cord-303322-d69o3z8d 148 3 non non JJ cord-303322-d69o3z8d 148 4 - - JJ cord-303322-d69o3z8d 148 5 susceptible susceptible JJ cord-303322-d69o3z8d 148 6 MIC mic NN cord-303322-d69o3z8d 148 7 > > XX cord-303322-d69o3z8d 149 1 0.12 0.12 CD cord-303322-d69o3z8d 149 2 μg μg NNP cord-303322-d69o3z8d 149 3 / / SYM cord-303322-d69o3z8d 149 4 mL mL NNP cord-303322-d69o3z8d 149 5 , , , cord-303322-d69o3z8d 149 6 azithromycin azithromycin NN cord-303322-d69o3z8d 149 7 resistant resistant JJ cord-303322-d69o3z8d 149 8 MIC MIC NNP cord-303322-d69o3z8d 149 9 ≥ ≥ CD cord-303322-d69o3z8d 149 10 2 2 CD cord-303322-d69o3z8d 149 11 μg μg NN cord-303322-d69o3z8d 149 12 / / SYM cord-303322-d69o3z8d 149 13 mL mL NNP cord-303322-d69o3z8d 149 14 , , , cord-303322-d69o3z8d 149 15 and and CC cord-303322-d69o3z8d 149 16 for for IN cord-303322-d69o3z8d 149 17 H. h. NN cord-303322-d69o3z8d 149 18 influenzae influenzae NN cord-303322-d69o3z8d 149 19 , , , cord-303322-d69o3z8d 149 20 ampicillin ampicillin JJ cord-303322-d69o3z8d 149 21 resistant resistant JJ cord-303322-d69o3z8d 149 22 MIC MIC NNP cord-303322-d69o3z8d 149 23 ≥ ≥ CD cord-303322-d69o3z8d 149 24 4 4 CD cord-303322-d69o3z8d 149 25 μg μg NN cord-303322-d69o3z8d 149 26 / / SYM cord-303322-d69o3z8d 149 27 mL mL NNP cord-303322-d69o3z8d 149 28 , , , cord-303322-d69o3z8d 149 29 azithromycin azithromycin NN cord-303322-d69o3z8d 149 30 resistant resistant JJ cord-303322-d69o3z8d 149 31 MIC MIC NNP cord-303322-d69o3z8d 150 1 > > XX cord-303322-d69o3z8d 151 1 4 4 CD cord-303322-d69o3z8d 151 2 μg/ μg/ ADD cord-303322-d69o3z8d 152 1 mL. mL. NNP cord-303322-d69o3z8d 152 2 Beta beta NN cord-303322-d69o3z8d 152 3 - - HYPH cord-303322-d69o3z8d 152 4 lactamase lactamase NN cord-303322-d69o3z8d 152 5 activity activity NN cord-303322-d69o3z8d 152 6 will will MD cord-303322-d69o3z8d 152 7 be be VB cord-303322-d69o3z8d 152 8 determined determine VBN cord-303322-d69o3z8d 152 9 for for IN cord-303322-d69o3z8d 152 10 H. h. NN cord-303322-d69o3z8d 152 11 influenzae influenzae NN cord-303322-d69o3z8d 152 12 and and CC cord-303322-d69o3z8d 152 13 M. M. NNP cord-303322-d69o3z8d 152 14 catarrhalis catarrhalis FW cord-303322-d69o3z8d 152 15 isolates isolate VBZ cord-303322-d69o3z8d 152 16 . . . cord-303322-d69o3z8d 153 1 Our -PRON- PRP$ cord-303322-d69o3z8d 153 2 previous previous JJ cord-303322-d69o3z8d 153 3 methods method NNS cord-303322-d69o3z8d 153 4 will will MD cord-303322-d69o3z8d 153 5 be be VB cord-303322-d69o3z8d 153 6 utilised utilise VBN cord-303322-d69o3z8d 153 7 [ [ -LRB- cord-303322-d69o3z8d 153 8 15 15 CD cord-303322-d69o3z8d 153 9 , , , cord-303322-d69o3z8d 153 10 38 38 CD cord-303322-d69o3z8d 153 11 , , , cord-303322-d69o3z8d 153 12 39 39 CD cord-303322-d69o3z8d 153 13 ] ] -RRB- cord-303322-d69o3z8d 153 14 . . . cord-303322-d69o3z8d 154 1 NPS NPS NNP cord-303322-d69o3z8d 154 2 are be VBP cord-303322-d69o3z8d 154 3 frozen freeze VBN cord-303322-d69o3z8d 154 4 at at IN cord-303322-d69o3z8d 154 5 -80 -80 NNP cord-303322-d69o3z8d 154 6 ° ° NN cord-303322-d69o3z8d 154 7 C C NNP cord-303322-d69o3z8d 154 8 . . . cord-303322-d69o3z8d 155 1 Upon upon IN cord-303322-d69o3z8d 155 2 thawing thaw VBG cord-303322-d69o3z8d 155 3 nucleic nucleic JJ cord-303322-d69o3z8d 155 4 acids acid NNS cord-303322-d69o3z8d 155 5 will will MD cord-303322-d69o3z8d 155 6 be be VB cord-303322-d69o3z8d 155 7 extracted extract VBN cord-303322-d69o3z8d 155 8 from from IN cord-303322-d69o3z8d 155 9 0.2 0.2 CD cord-303322-d69o3z8d 155 10 ml ml NNS cord-303322-d69o3z8d 155 11 of of IN cord-303322-d69o3z8d 155 12 each each DT cord-303322-d69o3z8d 155 13 NPS NPS NNP cord-303322-d69o3z8d 155 14 specimen specimen NN cord-303322-d69o3z8d 155 15 using use VBG cord-303322-d69o3z8d 155 16 the the DT cord-303322-d69o3z8d 155 17 High high JJ cord-303322-d69o3z8d 155 18 Pure pure JJ cord-303322-d69o3z8d 155 19 Viral Viral NNP cord-303322-d69o3z8d 155 20 Nucleic Nucleic NNP cord-303322-d69o3z8d 155 21 Acid acid NN cord-303322-d69o3z8d 155 22 kit kit NN cord-303322-d69o3z8d 155 23 ( ( -LRB- cord-303322-d69o3z8d 155 24 Roche Roche NNP cord-303322-d69o3z8d 155 25 Diagnostics Diagnostics NNP cord-303322-d69o3z8d 155 26 , , , cord-303322-d69o3z8d 155 27 Australia Australia NNP cord-303322-d69o3z8d 155 28 ) ) -RRB- cord-303322-d69o3z8d 155 29 , , , cord-303322-d69o3z8d 155 30 according accord VBG cord-303322-d69o3z8d 155 31 to to IN cord-303322-d69o3z8d 155 32 the the DT cord-303322-d69o3z8d 155 33 manufacturer manufacturer NN cord-303322-d69o3z8d 155 34 's 's POS cord-303322-d69o3z8d 155 35 instructions instruction NNS cord-303322-d69o3z8d 155 36 . . . cord-303322-d69o3z8d 156 1 Mono mono JJ cord-303322-d69o3z8d 156 2 - - HYPH cord-303322-d69o3z8d 156 3 specific specific JJ cord-303322-d69o3z8d 156 4 PCR PCR NNP cord-303322-d69o3z8d 156 5 and and CC cord-303322-d69o3z8d 156 6 reverse reverse VB cord-303322-d69o3z8d 156 7 transcriptase transcriptase NN cord-303322-d69o3z8d 156 8 PCR PCR NNP cord-303322-d69o3z8d 156 9 ( ( -LRB- cord-303322-d69o3z8d 156 10 RT RT NNP cord-303322-d69o3z8d 156 11 - - HYPH cord-303322-d69o3z8d 156 12 PCR PCR NNP cord-303322-d69o3z8d 156 13 ) ) -RRB- cord-303322-d69o3z8d 156 14 method method NN cord-303322-d69o3z8d 156 15 will will MD cord-303322-d69o3z8d 156 16 be be VB cord-303322-d69o3z8d 156 17 used use VBN cord-303322-d69o3z8d 156 18 to to TO cord-303322-d69o3z8d 156 19 detect detect VB cord-303322-d69o3z8d 156 20 Mycoplasma mycoplasma NN cord-303322-d69o3z8d 156 21 pneumoniae pneumoniae NN cord-303322-d69o3z8d 156 22 , , , cord-303322-d69o3z8d 156 23 coronaviruses coronaviruse NNS cord-303322-d69o3z8d 156 24 , , , cord-303322-d69o3z8d 156 25 bocavirus bocavirus NNP cord-303322-d69o3z8d 156 26 and and CC cord-303322-d69o3z8d 156 27 human human NNP cord-303322-d69o3z8d 156 28 metapneumovirus metapneumovirus NNP cord-303322-d69o3z8d 156 29 ( ( -LRB- cord-303322-d69o3z8d 156 30 hMPV hMPV NNP cord-303322-d69o3z8d 156 31 ) ) -RRB- cord-303322-d69o3z8d 156 32 , , , cord-303322-d69o3z8d 156 33 whereas whereas IN cord-303322-d69o3z8d 156 34 multiplex multiplex NN cord-303322-d69o3z8d 156 35 PCR PCR NNP cord-303322-d69o3z8d 156 36 and and CC cord-303322-d69o3z8d 156 37 RT RT NNP cord-303322-d69o3z8d 156 38 - - HYPH cord-303322-d69o3z8d 156 39 PCR PCR NNP cord-303322-d69o3z8d 156 40 was be VBD cord-303322-d69o3z8d 156 41 used use VBN cord-303322-d69o3z8d 156 42 to to TO cord-303322-d69o3z8d 156 43 detect detect VB cord-303322-d69o3z8d 156 44 adenovirus adenovirus NN cord-303322-d69o3z8d 156 45 , , , cord-303322-d69o3z8d 156 46 parainfluenza parainfluenza NNP cord-303322-d69o3z8d 156 47 ( ( -LRB- cord-303322-d69o3z8d 156 48 1 1 CD cord-303322-d69o3z8d 156 49 , , , cord-303322-d69o3z8d 156 50 2 2 CD cord-303322-d69o3z8d 156 51 3 3 CD cord-303322-d69o3z8d 156 52 ) ) -RRB- cord-303322-d69o3z8d 156 53 , , , cord-303322-d69o3z8d 156 54 influenza influenza NN cord-303322-d69o3z8d 156 55 ( ( -LRB- cord-303322-d69o3z8d 156 56 A a NN cord-303322-d69o3z8d 156 57 and and CC cord-303322-d69o3z8d 156 58 B B NNP cord-303322-d69o3z8d 156 59 ) ) -RRB- cord-303322-d69o3z8d 156 60 , , , cord-303322-d69o3z8d 156 61 and and CC cord-303322-d69o3z8d 156 62 respiratory respiratory JJ cord-303322-d69o3z8d 156 63 syncytial syncytial JJ cord-303322-d69o3z8d 156 64 virus virus NN cord-303322-d69o3z8d 156 65 ( ( -LRB- cord-303322-d69o3z8d 156 66 RSV RSV NNP cord-303322-d69o3z8d 156 67 ) ) -RRB- cord-303322-d69o3z8d 156 68 . . . cord-303322-d69o3z8d 157 1 All all PDT cord-303322-d69o3z8d 157 2 these these DT cord-303322-d69o3z8d 157 3 methods method NNS cord-303322-d69o3z8d 157 4 have have VBP cord-303322-d69o3z8d 157 5 been be VBN cord-303322-d69o3z8d 157 6 previously previously RB cord-303322-d69o3z8d 157 7 validated validate VBN cord-303322-d69o3z8d 157 8 in in IN cord-303322-d69o3z8d 157 9 our -PRON- PRP$ cord-303322-d69o3z8d 157 10 viral viral JJ cord-303322-d69o3z8d 157 11 laboratory laboratory NN cord-303322-d69o3z8d 157 12 at at IN cord-303322-d69o3z8d 157 13 the the DT cord-303322-d69o3z8d 157 14 Royal Royal NNP cord-303322-d69o3z8d 157 15 Children Children NNPS cord-303322-d69o3z8d 157 16 's 's POS cord-303322-d69o3z8d 157 17 Hospital Hospital NNP cord-303322-d69o3z8d 157 18 , , , cord-303322-d69o3z8d 157 19 Brisbane Brisbane NNP cord-303322-d69o3z8d 157 20 . . . cord-303322-d69o3z8d 158 1 Participation participation NN cord-303322-d69o3z8d 158 2 is be VBZ cord-303322-d69o3z8d 158 3 complete complete JJ cord-303322-d69o3z8d 158 4 when when WRB cord-303322-d69o3z8d 158 5 day-21 day-21 JJ cord-303322-d69o3z8d 158 6 outcomes outcome NNS cord-303322-d69o3z8d 158 7 have have VBP cord-303322-d69o3z8d 158 8 been be VBN cord-303322-d69o3z8d 158 9 obtained obtain VBN cord-303322-d69o3z8d 158 10 . . . cord-303322-d69o3z8d 159 1 Other other JJ cord-303322-d69o3z8d 159 2 exit exit NN cord-303322-d69o3z8d 159 3 points point NNS cord-303322-d69o3z8d 159 4 are be VBP cord-303322-d69o3z8d 159 5 : : : cord-303322-d69o3z8d 159 6 intolerance intolerance NN cord-303322-d69o3z8d 159 7 to to IN cord-303322-d69o3z8d 159 8 the the DT cord-303322-d69o3z8d 159 9 trial trial NN cord-303322-d69o3z8d 159 10 medications medication NNS cord-303322-d69o3z8d 159 11 requiring require VBG cord-303322-d69o3z8d 159 12 withdrawal withdrawal NN cord-303322-d69o3z8d 159 13 from from IN cord-303322-d69o3z8d 159 14 study study NN cord-303322-d69o3z8d 159 15 ( ( -LRB- cord-303322-d69o3z8d 159 16 as as IN cord-303322-d69o3z8d 159 17 deemed deem VBN cord-303322-d69o3z8d 159 18 by by IN cord-303322-d69o3z8d 159 19 the the DT cord-303322-d69o3z8d 159 20 treating treat VBG cord-303322-d69o3z8d 159 21 paediatrician paediatrician NN cord-303322-d69o3z8d 159 22 who who WP cord-303322-d69o3z8d 159 23 is be VBZ cord-303322-d69o3z8d 159 24 not not RB cord-303322-d69o3z8d 159 25 directly directly RB cord-303322-d69o3z8d 159 26 connected connect VBN cord-303322-d69o3z8d 159 27 to to IN cord-303322-d69o3z8d 159 28 the the DT cord-303322-d69o3z8d 159 29 study study NN cord-303322-d69o3z8d 159 30 team team NN cord-303322-d69o3z8d 159 31 ) ) -RRB- cord-303322-d69o3z8d 159 32 . . . cord-303322-d69o3z8d 160 1 ( ( -LRB- cord-303322-d69o3z8d 160 2 i i NN cord-303322-d69o3z8d 160 3 ) ) -RRB- cord-303322-d69o3z8d 160 4 Length length NN cord-303322-d69o3z8d 160 5 of of IN cord-303322-d69o3z8d 160 6 stay stay NN cord-303322-d69o3z8d 160 7 ( ( -LRB- cord-303322-d69o3z8d 160 8 LOS LOS NNP cord-303322-d69o3z8d 160 9 ) ) -RRB- cord-303322-d69o3z8d 160 10 for for IN cord-303322-d69o3z8d 160 11 respiratory respiratory JJ cord-303322-d69o3z8d 160 12 illness illness NN cord-303322-d69o3z8d 160 13 in in IN cord-303322-d69o3z8d 160 14 hospital hospital NN cord-303322-d69o3z8d 160 15 - - HYPH cord-303322-d69o3z8d 160 16 defined define VBN cord-303322-d69o3z8d 160 17 as as IN cord-303322-d69o3z8d 160 18 time time NN cord-303322-d69o3z8d 160 19 from from IN cord-303322-d69o3z8d 160 20 admission admission NN cord-303322-d69o3z8d 160 21 to to IN cord-303322-d69o3z8d 160 22 time time NN cord-303322-d69o3z8d 160 23 ' ' `` cord-303322-d69o3z8d 160 24 ready ready JJ cord-303322-d69o3z8d 160 25 for for IN cord-303322-d69o3z8d 160 26 discharge discharge NN cord-303322-d69o3z8d 160 27 ' ' '' cord-303322-d69o3z8d 160 28 for for IN cord-303322-d69o3z8d 160 29 respiratory respiratory JJ cord-303322-d69o3z8d 160 30 care care NN cord-303322-d69o3z8d 160 31 . . . cord-303322-d69o3z8d 160 32 ' ' '' cord-303322-d69o3z8d 161 1 Ready ready JJ cord-303322-d69o3z8d 161 2 for for IN cord-303322-d69o3z8d 161 3 discharge discharge NN cord-303322-d69o3z8d 161 4 ' ' '' cord-303322-d69o3z8d 161 5 means mean VBZ cord-303322-d69o3z8d 161 6 normoxic normoxic JJ cord-303322-d69o3z8d 162 1 ( ( -LRB- cord-303322-d69o3z8d 162 2 Sp0 sp0 NN cord-303322-d69o3z8d 162 3 2 2 CD cord-303322-d69o3z8d 162 4 consistently consistently RB cord-303322-d69o3z8d 162 5 > > XX cord-303322-d69o3z8d 162 6 94 94 CD cord-303322-d69o3z8d 162 7 % % NN cord-303322-d69o3z8d 162 8 in in IN cord-303322-d69o3z8d 162 9 air air NN cord-303322-d69o3z8d 162 10 for for IN cord-303322-d69o3z8d 162 11 > > XX cord-303322-d69o3z8d 162 12 16hrs 16hrs LS cord-303322-d69o3z8d 162 13 ) ) -RRB- cord-303322-d69o3z8d 162 14 and and CC cord-303322-d69o3z8d 162 15 feeding feed VBG cord-303322-d69o3z8d 162 16 adequately adequately RB cord-303322-d69o3z8d 162 17 ; ; : cord-303322-d69o3z8d 162 18 and and CC cord-303322-d69o3z8d 162 19 ( ( -LRB- cord-303322-d69o3z8d 162 20 ii ii NN cord-303322-d69o3z8d 162 21 ) ) -RRB- cord-303322-d69o3z8d 162 22 Duration duration NN cord-303322-d69o3z8d 162 23 of of IN cord-303322-d69o3z8d 162 24 supplemental supplemental JJ cord-303322-d69o3z8d 162 25 oxygen oxygen NN cord-303322-d69o3z8d 162 26 required require VBN cord-303322-d69o3z8d 162 27 . . . cord-303322-d69o3z8d 162 28 ' ' '' cord-303322-d69o3z8d 163 1 Ready ready JJ cord-303322-d69o3z8d 163 2 for for IN cord-303322-d69o3z8d 163 3 discharge discharge NN cord-303322-d69o3z8d 163 4 ' ' '' cord-303322-d69o3z8d 163 5 for for IN cord-303322-d69o3z8d 163 6 respiratory respiratory JJ cord-303322-d69o3z8d 163 7 care care NN cord-303322-d69o3z8d 163 8 differs differ VBZ cord-303322-d69o3z8d 163 9 from from IN cord-303322-d69o3z8d 163 10 length length NN cord-303322-d69o3z8d 163 11 of of IN cord-303322-d69o3z8d 163 12 hospitalisation hospitalisation NN cord-303322-d69o3z8d 163 13 as as IN cord-303322-d69o3z8d 163 14 discharge discharge NN cord-303322-d69o3z8d 163 15 from from IN cord-303322-d69o3z8d 163 16 hospital hospital NN cord-303322-d69o3z8d 163 17 may may MD cord-303322-d69o3z8d 163 18 be be VB cord-303322-d69o3z8d 163 19 delayed delay VBN cord-303322-d69o3z8d 163 20 because because IN cord-303322-d69o3z8d 163 21 of of IN cord-303322-d69o3z8d 163 22 social social JJ cord-303322-d69o3z8d 163 23 or or CC cord-303322-d69o3z8d 163 24 transport transport NN cord-303322-d69o3z8d 163 25 factors factor NNS cord-303322-d69o3z8d 163 26 especially especially RB cord-303322-d69o3z8d 163 27 in in IN cord-303322-d69o3z8d 163 28 children child NNS cord-303322-d69o3z8d 163 29 from from IN cord-303322-d69o3z8d 163 30 remote remote JJ cord-303322-d69o3z8d 163 31 communities community NNS cord-303322-d69o3z8d 163 32 . . . cord-303322-d69o3z8d 164 1 The the DT cord-303322-d69o3z8d 164 2 major major JJ cord-303322-d69o3z8d 164 3 secondary secondary JJ cord-303322-d69o3z8d 164 4 outcome outcome NN cord-303322-d69o3z8d 164 5 is be VBZ cord-303322-d69o3z8d 164 6 readmission readmission NN cord-303322-d69o3z8d 164 7 for for IN cord-303322-d69o3z8d 164 8 respiratory respiratory JJ cord-303322-d69o3z8d 164 9 illness illness NN cord-303322-d69o3z8d 164 10 ( ( -LRB- cord-303322-d69o3z8d 164 11 within within IN cord-303322-d69o3z8d 164 12 6-months 6-months CD cord-303322-d69o3z8d 164 13 of of IN cord-303322-d69o3z8d 164 14 discharge discharge NN cord-303322-d69o3z8d 164 15 from from IN cord-303322-d69o3z8d 164 16 hospital hospital NN cord-303322-d69o3z8d 164 17 ) ) -RRB- cord-303322-d69o3z8d 164 18 . . . cord-303322-d69o3z8d 165 1 Minor minor JJ cord-303322-d69o3z8d 165 2 outcomes outcome NNS cord-303322-d69o3z8d 165 3 during during IN cord-303322-d69o3z8d 165 4 hospitalisation hospitalisation NN cord-303322-d69o3z8d 165 5 : : : cord-303322-d69o3z8d 165 6 clinical clinical JJ cord-303322-d69o3z8d 165 7 severity severity NN cord-303322-d69o3z8d 165 8 score score NN cord-303322-d69o3z8d 165 9 , , , cord-303322-d69o3z8d 165 10 [ [ -LRB- cord-303322-d69o3z8d 165 11 27 27 CD cord-303322-d69o3z8d 165 12 ] ] -RRB- cord-303322-d69o3z8d 165 13 additional additional JJ cord-303322-d69o3z8d 165 14 use use NN cord-303322-d69o3z8d 165 15 of of IN cord-303322-d69o3z8d 165 16 antibiotics antibiotic NNS cord-303322-d69o3z8d 165 17 , , , cord-303322-d69o3z8d 165 18 and and CC cord-303322-d69o3z8d 165 19 episodes episode NNS cord-303322-d69o3z8d 165 20 of of IN cord-303322-d69o3z8d 165 21 suppurative suppurative JJ cord-303322-d69o3z8d 165 22 otitis otitis NN cord-303322-d69o3z8d 165 23 media medium NNS cord-303322-d69o3z8d 165 24 and and CC cord-303322-d69o3z8d 165 25 development development NN cord-303322-d69o3z8d 165 26 of of IN cord-303322-d69o3z8d 165 27 pneumonia pneumonia NN cord-303322-d69o3z8d 165 28 . . . cord-303322-d69o3z8d 166 1 The the DT cord-303322-d69o3z8d 166 2 Day-21 Day-21 NNP cord-303322-d69o3z8d 166 3 outcomes outcome NNS cord-303322-d69o3z8d 166 4 are be VBP cord-303322-d69o3z8d 166 5 : : : cord-303322-d69o3z8d 166 6 presence presence NN cord-303322-d69o3z8d 166 7 of of IN cord-303322-d69o3z8d 166 8 cough cough NN cord-303322-d69o3z8d 166 9 , , , cord-303322-d69o3z8d 166 10 wheeze wheeze NN cord-303322-d69o3z8d 166 11 , , , cord-303322-d69o3z8d 166 12 abnormal abnormal JJ cord-303322-d69o3z8d 166 13 auscultatory auscultatory IN cord-303322-d69o3z8d 166 14 chest chest NN cord-303322-d69o3z8d 166 15 signs sign NNS cord-303322-d69o3z8d 166 16 and and CC cord-303322-d69o3z8d 166 17 suppurative suppurative JJ cord-303322-d69o3z8d 166 18 otitis otitis NN cord-303322-d69o3z8d 166 19 media medium NNS cord-303322-d69o3z8d 166 20 . . . cord-303322-d69o3z8d 167 1 We -PRON- PRP cord-303322-d69o3z8d 167 2 will will MD cord-303322-d69o3z8d 167 3 also also RB cord-303322-d69o3z8d 167 4 analyse analyse VB cord-303322-d69o3z8d 167 5 all all DT cord-303322-d69o3z8d 167 6 clinical clinical JJ cord-303322-d69o3z8d 167 7 outcomes outcome NNS cord-303322-d69o3z8d 167 8 in in IN cord-303322-d69o3z8d 167 9 the the DT cord-303322-d69o3z8d 167 10 following follow VBG cord-303322-d69o3z8d 167 11 pre pre JJ cord-303322-d69o3z8d 167 12 - - JJ cord-303322-d69o3z8d 167 13 determined determined JJ cord-303322-d69o3z8d 167 14 sub sub NN cord-303322-d69o3z8d 167 15 - - NNS cord-303322-d69o3z8d 167 16 groups group NNS cord-303322-d69o3z8d 167 17 : : : cord-303322-d69o3z8d 168 1 ( ( -LRB- cord-303322-d69o3z8d 168 2 i i NN cord-303322-d69o3z8d 168 3 ) ) -RRB- cord-303322-d69o3z8d 168 4 age age NN cord-303322-d69o3z8d 168 5 ≤ ≤ NNS cord-303322-d69o3z8d 168 6 6-months 6-months CD cord-303322-d69o3z8d 168 7 ; ; : cord-303322-d69o3z8d 168 8 and and CC cord-303322-d69o3z8d 168 9 ( ( -LRB- cord-303322-d69o3z8d 168 10 ii ii NN cord-303322-d69o3z8d 168 11 ) ) -RRB- cord-303322-d69o3z8d 168 12 presence presence NN cord-303322-d69o3z8d 168 13 of of IN cord-303322-d69o3z8d 168 14 bacterial bacterial JJ cord-303322-d69o3z8d 168 15 respiratory respiratory JJ cord-303322-d69o3z8d 168 16 pathogens pathogen NNS cord-303322-d69o3z8d 168 17 that that WDT cord-303322-d69o3z8d 168 18 are be VBP cord-303322-d69o3z8d 168 19 resistant resistant JJ cord-303322-d69o3z8d 168 20 to to IN cord-303322-d69o3z8d 168 21 macrolide macrolide JJ cord-303322-d69o3z8d 168 22 antibiotics antibiotic NNS cord-303322-d69o3z8d 168 23 . . . cord-303322-d69o3z8d 169 1 ( ( -LRB- cord-303322-d69o3z8d 169 2 i i NN cord-303322-d69o3z8d 169 3 ) ) -RRB- cord-303322-d69o3z8d 169 4 identification identification NN cord-303322-d69o3z8d 169 5 of of IN cord-303322-d69o3z8d 169 6 respiratory respiratory JJ cord-303322-d69o3z8d 169 7 viruses virus NNS cord-303322-d69o3z8d 169 8 and and CC cord-303322-d69o3z8d 169 9 bacterial bacterial JJ cord-303322-d69o3z8d 169 10 pathogens pathogen NNS cord-303322-d69o3z8d 169 11 and and CC cord-303322-d69o3z8d 169 12 ( ( -LRB- cord-303322-d69o3z8d 169 13 ii ii NN cord-303322-d69o3z8d 169 14 ) ) -RRB- cord-303322-d69o3z8d 169 15 antibiotic antibiotic JJ cord-303322-d69o3z8d 169 16 resistance resistance NN cord-303322-d69o3z8d 169 17 to to IN cord-303322-d69o3z8d 169 18 penicillin penicillin NN cord-303322-d69o3z8d 169 19 and and CC cord-303322-d69o3z8d 169 20 macrolides macrolide NNS cord-303322-d69o3z8d 169 21 . . . cord-303322-d69o3z8d 170 1 We -PRON- PRP cord-303322-d69o3z8d 170 2 plan plan VBP cord-303322-d69o3z8d 170 3 to to TO cord-303322-d69o3z8d 170 4 enrol enrol VB cord-303322-d69o3z8d 170 5 200 200 CD cord-303322-d69o3z8d 170 6 Indigenous indigenous JJ cord-303322-d69o3z8d 170 7 infants infant NNS cord-303322-d69o3z8d 170 8 . . . cord-303322-d69o3z8d 171 1 In in IN cord-303322-d69o3z8d 171 2 our -PRON- PRP$ cord-303322-d69o3z8d 171 3 retrospective retrospective JJ cord-303322-d69o3z8d 171 4 study study NN cord-303322-d69o3z8d 171 5 , , , cord-303322-d69o3z8d 171 6 [ [ -LRB- cord-303322-d69o3z8d 171 7 6 6 CD cord-303322-d69o3z8d 171 8 ] ] -RRB- cord-303322-d69o3z8d 171 9 the the DT cord-303322-d69o3z8d 171 10 mean mean JJ cord-303322-d69o3z8d 171 11 LOS LOS NNP cord-303322-d69o3z8d 171 12 in in IN cord-303322-d69o3z8d 171 13 Indigenous indigenous JJ cord-303322-d69o3z8d 171 14 infants infant NNS cord-303322-d69o3z8d 171 15 with with IN cord-303322-d69o3z8d 171 16 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 171 17 at at IN cord-303322-d69o3z8d 171 18 RDH RDH NNP cord-303322-d69o3z8d 171 19 was be VBD cord-303322-d69o3z8d 171 20 96 96 CD cord-303322-d69o3z8d 171 21 ( ( -LRB- cord-303322-d69o3z8d 171 22 SD SD NNP cord-303322-d69o3z8d 171 23 24 24 CD cord-303322-d69o3z8d 171 24 ) ) -RRB- cord-303322-d69o3z8d 171 25 hours hour NNS cord-303322-d69o3z8d 171 26 . . . cord-303322-d69o3z8d 172 1 The the DT cord-303322-d69o3z8d 172 2 mean mean JJ cord-303322-d69o3z8d 172 3 duration duration NN cord-303322-d69o3z8d 172 4 of of IN cord-303322-d69o3z8d 172 5 supplemental supplemental JJ cord-303322-d69o3z8d 172 6 oxygen oxygen NN cord-303322-d69o3z8d 172 7 requirement requirement NN cord-303322-d69o3z8d 172 8 in in IN cord-303322-d69o3z8d 172 9 Indigenous indigenous JJ cord-303322-d69o3z8d 172 10 infants infant NNS cord-303322-d69o3z8d 172 11 with with IN cord-303322-d69o3z8d 172 12 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 172 13 was be VBD cord-303322-d69o3z8d 172 14 36 36 CD cord-303322-d69o3z8d 172 15 ( ( -LRB- cord-303322-d69o3z8d 172 16 SD SD NNP cord-303322-d69o3z8d 172 17 14 14 CD cord-303322-d69o3z8d 172 18 ) ) -RRB- cord-303322-d69o3z8d 172 19 hours hour NNS cord-303322-d69o3z8d 172 20 . . . cord-303322-d69o3z8d 173 1 For for IN cord-303322-d69o3z8d 173 2 a a DT cord-303322-d69o3z8d 173 3 mean mean JJ cord-303322-d69o3z8d 173 4 difference difference NN cord-303322-d69o3z8d 173 5 of of IN cord-303322-d69o3z8d 173 6 24-hours 24-hours CD cord-303322-d69o3z8d 173 7 in in IN cord-303322-d69o3z8d 173 8 LOS LOS NNP cord-303322-d69o3z8d 173 9 between between IN cord-303322-d69o3z8d 173 10 groups group NNS cord-303322-d69o3z8d 173 11 ( ( -LRB- cord-303322-d69o3z8d 173 12 power power NN cord-303322-d69o3z8d 173 13 = = SYM cord-303322-d69o3z8d 173 14 90 90 CD cord-303322-d69o3z8d 173 15 % % NN cord-303322-d69o3z8d 173 16 , , , cord-303322-d69o3z8d 173 17 α α NN cord-303322-d69o3z8d 173 18 = = SYM cord-303322-d69o3z8d 173 19 5 5 CD cord-303322-d69o3z8d 173 20 % % NN cord-303322-d69o3z8d 173 21 ) ) -RRB- cord-303322-d69o3z8d 173 22 the the DT cord-303322-d69o3z8d 173 23 required require VBN cord-303322-d69o3z8d 173 24 sample sample NN cord-303322-d69o3z8d 173 25 size size NN cord-303322-d69o3z8d 173 26 is be VBZ cord-303322-d69o3z8d 173 27 23 23 CD cord-303322-d69o3z8d 173 28 per per IN cord-303322-d69o3z8d 173 29 group group NN cord-303322-d69o3z8d 173 30 . . . cord-303322-d69o3z8d 174 1 The the DT cord-303322-d69o3z8d 174 2 numbers number NNS cord-303322-d69o3z8d 174 3 to to TO cord-303322-d69o3z8d 174 4 detect detect VB cord-303322-d69o3z8d 174 5 a a DT cord-303322-d69o3z8d 174 6 12-hour 12-hour JJ cord-303322-d69o3z8d 174 7 difference difference NN cord-303322-d69o3z8d 174 8 in in IN cord-303322-d69o3z8d 174 9 supplemental supplemental JJ cord-303322-d69o3z8d 174 10 oxygen oxygen NN cord-303322-d69o3z8d 174 11 requirement requirement NN cord-303322-d69o3z8d 174 12 is be VBZ cord-303322-d69o3z8d 174 13 30 30 CD cord-303322-d69o3z8d 174 14 per per IN cord-303322-d69o3z8d 174 15 group group NN cord-303322-d69o3z8d 174 16 . . . cord-303322-d69o3z8d 175 1 These these DT cord-303322-d69o3z8d 175 2 are be VBP cord-303322-d69o3z8d 175 3 large large JJ cord-303322-d69o3z8d 175 4 effect effect NN cord-303322-d69o3z8d 175 5 sizes size NNS cord-303322-d69o3z8d 175 6 but but CC cord-303322-d69o3z8d 175 7 more more JJR cord-303322-d69o3z8d 175 8 conservative conservative JJ cord-303322-d69o3z8d 175 9 estimates estimate NNS cord-303322-d69o3z8d 175 10 than than IN cord-303322-d69o3z8d 175 11 seen see VBN cord-303322-d69o3z8d 175 12 in in IN cord-303322-d69o3z8d 175 13 the the DT cord-303322-d69o3z8d 175 14 Turkish turkish JJ cord-303322-d69o3z8d 175 15 study study NN cord-303322-d69o3z8d 175 16 [ [ -LRB- cord-303322-d69o3z8d 175 17 26 26 CD cord-303322-d69o3z8d 175 18 ] ] -RRB- cord-303322-d69o3z8d 175 19 . . . cord-303322-d69o3z8d 176 1 In in IN cord-303322-d69o3z8d 176 2 that that DT cord-303322-d69o3z8d 176 3 study study NN cord-303322-d69o3z8d 176 4 , , , cord-303322-d69o3z8d 176 5 [ [ -LRB- cord-303322-d69o3z8d 176 6 26 26 CD cord-303322-d69o3z8d 176 7 ] ] -RRB- cord-303322-d69o3z8d 176 8 the the DT cord-303322-d69o3z8d 176 9 difference difference NN cord-303322-d69o3z8d 176 10 between between IN cord-303322-d69o3z8d 176 11 groups group NNS cord-303322-d69o3z8d 176 12 was be VBD cord-303322-d69o3z8d 176 13 30-hrs 30-hrs CD cord-303322-d69o3z8d 176 14 for for IN cord-303322-d69o3z8d 176 15 LOS LOS NNP cord-303322-d69o3z8d 176 16 and and CC cord-303322-d69o3z8d 176 17 31-hours 31-hours CD cord-303322-d69o3z8d 176 18 for for IN cord-303322-d69o3z8d 176 19 supplemental supplemental JJ cord-303322-d69o3z8d 176 20 oxygen oxygen NN cord-303322-d69o3z8d 176 21 requirement requirement NN cord-303322-d69o3z8d 176 22 . . . cord-303322-d69o3z8d 177 1 Assuming assume VBG cord-303322-d69o3z8d 177 2 similar similar JJ cord-303322-d69o3z8d 177 3 effects effect NNS cord-303322-d69o3z8d 177 4 , , , cord-303322-d69o3z8d 177 5 a a DT cord-303322-d69o3z8d 177 6 sample sample NN cord-303322-d69o3z8d 177 7 size size NN cord-303322-d69o3z8d 177 8 of of IN cord-303322-d69o3z8d 177 9 at at RB cord-303322-d69o3z8d 177 10 least least RBS cord-303322-d69o3z8d 177 11 100 100 CD cord-303322-d69o3z8d 177 12 in in IN cord-303322-d69o3z8d 177 13 each each DT cord-303322-d69o3z8d 177 14 sub sub JJ cord-303322-d69o3z8d 177 15 - - JJ cord-303322-d69o3z8d 177 16 age age JJ cord-303322-d69o3z8d 177 17 group group NN cord-303322-d69o3z8d 177 18 is be VBZ cord-303322-d69o3z8d 177 19 also also RB cord-303322-d69o3z8d 177 20 sufficient sufficient JJ cord-303322-d69o3z8d 177 21 for for IN cord-303322-d69o3z8d 177 22 an an DT cord-303322-d69o3z8d 177 23 a a DT cord-303322-d69o3z8d 177 24 - - HYPH cord-303322-d69o3z8d 177 25 priori priori JJ cord-303322-d69o3z8d 177 26 subgroup subgroup NN cord-303322-d69o3z8d 177 27 analysis analysis NN cord-303322-d69o3z8d 177 28 based base VBN cord-303322-d69o3z8d 177 29 on on IN cord-303322-d69o3z8d 177 30 age age NN cord-303322-d69o3z8d 177 31 ( ( -LRB- cord-303322-d69o3z8d 177 32 power power NN cord-303322-d69o3z8d 177 33 of of IN cord-303322-d69o3z8d 177 34 90 90 CD cord-303322-d69o3z8d 177 35 % % NN cord-303322-d69o3z8d 177 36 and and CC cord-303322-d69o3z8d 177 37 2-tailed 2-tailed CD cord-303322-d69o3z8d 177 38 α α NN cord-303322-d69o3z8d 177 39 of of IN cord-303322-d69o3z8d 177 40 5 5 CD cord-303322-d69o3z8d 177 41 % % NN cord-303322-d69o3z8d 177 42 ) ) -RRB- cord-303322-d69o3z8d 177 43 . . . cord-303322-d69o3z8d 178 1 If if IN cord-303322-d69o3z8d 178 2 the the DT cord-303322-d69o3z8d 178 3 effects effect NNS cord-303322-d69o3z8d 178 4 are be VBP cord-303322-d69o3z8d 178 5 smaller small JJR cord-303322-d69o3z8d 178 6 , , , cord-303322-d69o3z8d 178 7 we -PRON- PRP cord-303322-d69o3z8d 178 8 will will MD cord-303322-d69o3z8d 178 9 have have VB cord-303322-d69o3z8d 178 10 an an DT cord-303322-d69o3z8d 178 11 80 80 CD cord-303322-d69o3z8d 178 12 % % NN cord-303322-d69o3z8d 178 13 power power NN cord-303322-d69o3z8d 178 14 to to TO cord-303322-d69o3z8d 178 15 detect detect VB cord-303322-d69o3z8d 178 16 a a DT cord-303322-d69o3z8d 178 17 difference difference NN cord-303322-d69o3z8d 178 18 of of IN cord-303322-d69o3z8d 178 19 10hours 10hours CD cord-303322-d69o3z8d 178 20 in in IN cord-303322-d69o3z8d 178 21 LOS LOS NNP cord-303322-d69o3z8d 178 22 in in IN cord-303322-d69o3z8d 178 23 all all DT cord-303322-d69o3z8d 178 24 infants infant NNS cord-303322-d69o3z8d 178 25 and and CC cord-303322-d69o3z8d 178 26 an an DT cord-303322-d69o3z8d 178 27 80 80 CD cord-303322-d69o3z8d 178 28 % % NN cord-303322-d69o3z8d 178 29 power power NN cord-303322-d69o3z8d 178 30 to to TO cord-303322-d69o3z8d 178 31 detect detect VB cord-303322-d69o3z8d 178 32 a a DT cord-303322-d69o3z8d 178 33 difference difference NN cord-303322-d69o3z8d 178 34 of of IN cord-303322-d69o3z8d 178 35 14-hours 14-hours CD cord-303322-d69o3z8d 178 36 in in IN cord-303322-d69o3z8d 178 37 LOS LOS NNP cord-303322-d69o3z8d 178 38 in in IN cord-303322-d69o3z8d 178 39 the the DT cord-303322-d69o3z8d 178 40 ≤6-months ≤6-months NNP cord-303322-d69o3z8d 178 41 age age NN cord-303322-d69o3z8d 178 42 group group NN cord-303322-d69o3z8d 178 43 . . . cord-303322-d69o3z8d 179 1 We -PRON- PRP cord-303322-d69o3z8d 179 2 do do VBP cord-303322-d69o3z8d 179 3 not not RB cord-303322-d69o3z8d 179 4 believe believe VB cord-303322-d69o3z8d 179 5 that that IN cord-303322-d69o3z8d 179 6 smaller small JJR cord-303322-d69o3z8d 179 7 benefits benefit NNS cord-303322-d69o3z8d 179 8 than than IN cord-303322-d69o3z8d 179 9 this this DT cord-303322-d69o3z8d 179 10 would would MD cord-303322-d69o3z8d 179 11 be be VB cord-303322-d69o3z8d 179 12 sufficient sufficient JJ cord-303322-d69o3z8d 179 13 to to TO cord-303322-d69o3z8d 179 14 change change VB cord-303322-d69o3z8d 179 15 clinical clinical JJ cord-303322-d69o3z8d 179 16 practice practice NN cord-303322-d69o3z8d 179 17 . . . cord-303322-d69o3z8d 180 1 For for IN cord-303322-d69o3z8d 180 2 the the DT cord-303322-d69o3z8d 180 3 most most RBS cord-303322-d69o3z8d 180 4 important important JJ cord-303322-d69o3z8d 180 5 secondary secondary JJ cord-303322-d69o3z8d 180 6 outcome outcome NN cord-303322-d69o3z8d 180 7 ( ( -LRB- cord-303322-d69o3z8d 180 8 readmission readmission NN cord-303322-d69o3z8d 180 9 rate rate NN cord-303322-d69o3z8d 180 10 for for IN cord-303322-d69o3z8d 180 11 a a DT cord-303322-d69o3z8d 180 12 respiratory respiratory JJ cord-303322-d69o3z8d 180 13 illness illness NN cord-303322-d69o3z8d 180 14 within within IN cord-303322-d69o3z8d 180 15 6-months 6-months CD cord-303322-d69o3z8d 180 16 of of IN cord-303322-d69o3z8d 180 17 discharge discharge NN cord-303322-d69o3z8d 180 18 ) ) -RRB- cord-303322-d69o3z8d 180 19 , , , cord-303322-d69o3z8d 180 20 the the DT cord-303322-d69o3z8d 180 21 power power NN cord-303322-d69o3z8d 180 22 of of IN cord-303322-d69o3z8d 180 23 our -PRON- PRP$ cord-303322-d69o3z8d 180 24 study study NN cord-303322-d69o3z8d 180 25 to to TO cord-303322-d69o3z8d 180 26 detect detect VB cord-303322-d69o3z8d 180 27 a a DT cord-303322-d69o3z8d 180 28 reduction reduction NN cord-303322-d69o3z8d 180 29 from from IN cord-303322-d69o3z8d 180 30 30 30 CD cord-303322-d69o3z8d 180 31 % % NN cord-303322-d69o3z8d 180 32 to to TO cord-303322-d69o3z8d 180 33 10 10 CD cord-303322-d69o3z8d 180 34 % % NN cord-303322-d69o3z8d 180 35 is be VBZ cord-303322-d69o3z8d 180 36 95 95 CD cord-303322-d69o3z8d 180 37 % % NN cord-303322-d69o3z8d 180 38 ( ( -LRB- cord-303322-d69o3z8d 180 39 5 5 CD cord-303322-d69o3z8d 180 40 % % NN cord-303322-d69o3z8d 180 41 significance significance NN cord-303322-d69o3z8d 180 42 ) ) -RRB- cord-303322-d69o3z8d 180 43 . . . cord-303322-d69o3z8d 181 1 This this DT cord-303322-d69o3z8d 181 2 is be VBZ cord-303322-d69o3z8d 181 3 a a DT cord-303322-d69o3z8d 181 4 large large JJ cord-303322-d69o3z8d 181 5 effect effect NN cord-303322-d69o3z8d 181 6 but but CC cord-303322-d69o3z8d 181 7 consistent consistent JJ cord-303322-d69o3z8d 181 8 with with IN cord-303322-d69o3z8d 181 9 the the DT cord-303322-d69o3z8d 181 10 reduction reduction NN cord-303322-d69o3z8d 181 11 described describe VBN cord-303322-d69o3z8d 181 12 in in IN cord-303322-d69o3z8d 181 13 the the DT cord-303322-d69o3z8d 181 14 Turkish turkish JJ cord-303322-d69o3z8d 181 15 study study NN cord-303322-d69o3z8d 181 16 ( ( -LRB- cord-303322-d69o3z8d 181 17 75 75 CD cord-303322-d69o3z8d 181 18 % % NN cord-303322-d69o3z8d 181 19 reduction reduction NN cord-303322-d69o3z8d 181 20 ) ) -RRB- cord-303322-d69o3z8d 181 21 [ [ -LRB- cord-303322-d69o3z8d 181 22 26 26 CD cord-303322-d69o3z8d 181 23 ] ] -RRB- cord-303322-d69o3z8d 181 24 . . . cord-303322-d69o3z8d 182 1 At at IN cord-303322-d69o3z8d 182 2 80 80 CD cord-303322-d69o3z8d 182 3 % % NN cord-303322-d69o3z8d 182 4 power power NN cord-303322-d69o3z8d 182 5 we -PRON- PRP cord-303322-d69o3z8d 182 6 will will MD cord-303322-d69o3z8d 182 7 be be VB cord-303322-d69o3z8d 182 8 able able JJ cord-303322-d69o3z8d 182 9 to to TO cord-303322-d69o3z8d 182 10 detect detect VB cord-303322-d69o3z8d 182 11 a a DT cord-303322-d69o3z8d 182 12 reduction reduction NN cord-303322-d69o3z8d 182 13 in in IN cord-303322-d69o3z8d 182 14 readmission readmission NN cord-303322-d69o3z8d 182 15 rates rate NNS cord-303322-d69o3z8d 182 16 from from IN cord-303322-d69o3z8d 182 17 30 30 CD cord-303322-d69o3z8d 182 18 % % NN cord-303322-d69o3z8d 182 19 to to TO cord-303322-d69o3z8d 182 20 13 13 CD cord-303322-d69o3z8d 182 21 % % NN cord-303322-d69o3z8d 182 22 . . . cord-303322-d69o3z8d 183 1 For for IN cord-303322-d69o3z8d 183 2 our -PRON- PRP$ cord-303322-d69o3z8d 183 3 other other JJ cord-303322-d69o3z8d 183 4 secondary secondary JJ cord-303322-d69o3z8d 183 5 outcomes outcome NNS cord-303322-d69o3z8d 183 6 , , , cord-303322-d69o3z8d 183 7 accurate accurate JJ cord-303322-d69o3z8d 183 8 sample sample NN cord-303322-d69o3z8d 183 9 size size NN cord-303322-d69o3z8d 183 10 estimations estimation NNS cord-303322-d69o3z8d 183 11 are be VBP cord-303322-d69o3z8d 183 12 not not RB cord-303322-d69o3z8d 183 13 possible possible JJ cord-303322-d69o3z8d 183 14 given give VBN cord-303322-d69o3z8d 183 15 the the DT cord-303322-d69o3z8d 183 16 lack lack NN cord-303322-d69o3z8d 183 17 of of IN cord-303322-d69o3z8d 183 18 any any DT cord-303322-d69o3z8d 183 19 relevant relevant JJ cord-303322-d69o3z8d 183 20 data datum NNS cord-303322-d69o3z8d 183 21 . . . cord-303322-d69o3z8d 184 1 Data datum NNS cord-303322-d69o3z8d 184 2 will will MD cord-303322-d69o3z8d 184 3 be be VB cord-303322-d69o3z8d 184 4 reported report VBN cord-303322-d69o3z8d 184 5 and and CC cord-303322-d69o3z8d 184 6 presented present VBN cord-303322-d69o3z8d 184 7 in in IN cord-303322-d69o3z8d 184 8 accordance accordance NN cord-303322-d69o3z8d 184 9 with with IN cord-303322-d69o3z8d 184 10 the the DT cord-303322-d69o3z8d 184 11 updated update VBN cord-303322-d69o3z8d 184 12 CONSORT CONSORT NNP cord-303322-d69o3z8d 184 13 criteria criterion NNS cord-303322-d69o3z8d 184 14 [ [ -LRB- cord-303322-d69o3z8d 184 15 40 40 CD cord-303322-d69o3z8d 184 16 ] ] -RRB- cord-303322-d69o3z8d 184 17 . . . cord-303322-d69o3z8d 185 1 Children child NNS cord-303322-d69o3z8d 185 2 will will MD cord-303322-d69o3z8d 185 3 be be VB cord-303322-d69o3z8d 185 4 analysed analyse VBN cord-303322-d69o3z8d 185 5 according accord VBG cord-303322-d69o3z8d 185 6 to to IN cord-303322-d69o3z8d 185 7 allocation allocation NN cord-303322-d69o3z8d 185 8 status status NN cord-303322-d69o3z8d 185 9 ( ( -LRB- cord-303322-d69o3z8d 185 10 regardless regardless RB cord-303322-d69o3z8d 185 11 of of IN cord-303322-d69o3z8d 185 12 subsequent subsequent JJ cord-303322-d69o3z8d 185 13 management management NN cord-303322-d69o3z8d 185 14 ) ) -RRB- cord-303322-d69o3z8d 185 15 . . . cord-303322-d69o3z8d 186 1 An an DT cord-303322-d69o3z8d 186 2 interim interim JJ cord-303322-d69o3z8d 186 3 analysis analysis NN cord-303322-d69o3z8d 186 4 is be VBZ cord-303322-d69o3z8d 186 5 planned plan VBN cord-303322-d69o3z8d 186 6 and and CC cord-303322-d69o3z8d 186 7 the the DT cord-303322-d69o3z8d 186 8 data data NN cord-303322-d69o3z8d 186 9 safety safety NN cord-303322-d69o3z8d 186 10 and and CC cord-303322-d69o3z8d 186 11 monitoring monitoring NN cord-303322-d69o3z8d 186 12 committee committee NN cord-303322-d69o3z8d 186 13 will will MD cord-303322-d69o3z8d 186 14 determine determine VB cord-303322-d69o3z8d 186 15 if if IN cord-303322-d69o3z8d 186 16 the the DT cord-303322-d69o3z8d 186 17 study study NN cord-303322-d69o3z8d 186 18 should should MD cord-303322-d69o3z8d 186 19 be be VB cord-303322-d69o3z8d 186 20 ceased cease VBN cord-303322-d69o3z8d 186 21 should should MD cord-303322-d69o3z8d 186 22 superiority superiority NN cord-303322-d69o3z8d 186 23 of of IN cord-303322-d69o3z8d 186 24 azithromycin azithromycin NNP cord-303322-d69o3z8d 186 25 be be VB cord-303322-d69o3z8d 186 26 identified identify VBN cord-303322-d69o3z8d 186 27 after after IN cord-303322-d69o3z8d 186 28 70 70 CD cord-303322-d69o3z8d 186 29 % % NN cord-303322-d69o3z8d 186 30 of of IN cord-303322-d69o3z8d 186 31 sample sample NN cord-303322-d69o3z8d 186 32 size size NN cord-303322-d69o3z8d 186 33 is be VBZ cord-303322-d69o3z8d 186 34 achieved achieve VBN cord-303322-d69o3z8d 186 35 . . . cord-303322-d69o3z8d 187 1 The the DT cord-303322-d69o3z8d 187 2 primary primary JJ cord-303322-d69o3z8d 187 3 outcomes outcome NNS cord-303322-d69o3z8d 187 4 ( ( -LRB- cord-303322-d69o3z8d 187 5 LOS LOS NNP cord-303322-d69o3z8d 187 6 and and CC cord-303322-d69o3z8d 187 7 duration duration NN cord-303322-d69o3z8d 187 8 of of IN cord-303322-d69o3z8d 187 9 supplemental supplemental JJ cord-303322-d69o3z8d 187 10 oxygen oxygen NN cord-303322-d69o3z8d 187 11 requirement requirement NN cord-303322-d69o3z8d 187 12 ) ) -RRB- cord-303322-d69o3z8d 187 13 will will MD cord-303322-d69o3z8d 187 14 be be VB cord-303322-d69o3z8d 187 15 compared compare VBN cord-303322-d69o3z8d 187 16 between between IN cord-303322-d69o3z8d 187 17 infants infant NNS cord-303322-d69o3z8d 187 18 receiving receive VBG cord-303322-d69o3z8d 187 19 placebo placebo NN cord-303322-d69o3z8d 187 20 or or CC cord-303322-d69o3z8d 187 21 azithromycin azithromycin NNS cord-303322-d69o3z8d 187 22 using use VBG cord-303322-d69o3z8d 187 23 unpaired unpaired JJ cord-303322-d69o3z8d 187 24 Student Student NNP cord-303322-d69o3z8d 187 25 's 's POS cord-303322-d69o3z8d 187 26 T t NN cord-303322-d69o3z8d 187 27 - - HYPH cord-303322-d69o3z8d 187 28 tests test NNS cord-303322-d69o3z8d 187 29 or or CC cord-303322-d69o3z8d 187 30 Mann Mann NNP cord-303322-d69o3z8d 187 31 - - HYPH cord-303322-d69o3z8d 187 32 Whitney Whitney NNP cord-303322-d69o3z8d 187 33 tests test VBZ cord-303322-d69o3z8d 187 34 ( ( -LRB- cord-303322-d69o3z8d 187 35 depending depend VBG cord-303322-d69o3z8d 187 36 on on IN cord-303322-d69o3z8d 187 37 normality normality NN cord-303322-d69o3z8d 187 38 of of IN cord-303322-d69o3z8d 187 39 distribution distribution NN cord-303322-d69o3z8d 187 40 ) ) -RRB- cord-303322-d69o3z8d 187 41 . . . cord-303322-d69o3z8d 188 1 Although although IN cord-303322-d69o3z8d 188 2 we -PRON- PRP cord-303322-d69o3z8d 188 3 expect expect VBP cord-303322-d69o3z8d 188 4 randomisation randomisation NN cord-303322-d69o3z8d 188 5 to to TO cord-303322-d69o3z8d 188 6 equally equally RB cord-303322-d69o3z8d 188 7 distribute distribute VB cord-303322-d69o3z8d 188 8 potential potential JJ cord-303322-d69o3z8d 188 9 confounding confounding JJ cord-303322-d69o3z8d 188 10 factors factor NNS cord-303322-d69o3z8d 188 11 between between IN cord-303322-d69o3z8d 188 12 each each DT cord-303322-d69o3z8d 188 13 of of IN cord-303322-d69o3z8d 188 14 the the DT cord-303322-d69o3z8d 188 15 groups group NNS cord-303322-d69o3z8d 188 16 , , , cord-303322-d69o3z8d 188 17 we -PRON- PRP cord-303322-d69o3z8d 188 18 will will MD cord-303322-d69o3z8d 188 19 examine examine VB cord-303322-d69o3z8d 188 20 the the DT cord-303322-d69o3z8d 188 21 distribution distribution NN cord-303322-d69o3z8d 188 22 of of IN cord-303322-d69o3z8d 188 23 known know VBN cord-303322-d69o3z8d 188 24 confounders confounder NNS cord-303322-d69o3z8d 188 25 between between IN cord-303322-d69o3z8d 188 26 groups group NNS cord-303322-d69o3z8d 188 27 ( ( -LRB- cord-303322-d69o3z8d 188 28 eg eg IN cord-303322-d69o3z8d 188 29 . . . cord-303322-d69o3z8d 188 30 birth birth NN cord-303322-d69o3z8d 188 31 weight weight NN cord-303322-d69o3z8d 188 32 , , , cord-303322-d69o3z8d 188 33 smoke smoke NN cord-303322-d69o3z8d 188 34 exposure exposure NN cord-303322-d69o3z8d 188 35 status status NN cord-303322-d69o3z8d 188 36 in in IN cord-303322-d69o3z8d 188 37 - - HYPH cord-303322-d69o3z8d 188 38 utero utero NN cord-303322-d69o3z8d 188 39 and and CC cord-303322-d69o3z8d 188 40 postnatal postnatal NN cord-303322-d69o3z8d 188 41 , , , cord-303322-d69o3z8d 188 42 breast breast NN cord-303322-d69o3z8d 188 43 feeding feeding NN cord-303322-d69o3z8d 188 44 , , , cord-303322-d69o3z8d 188 45 etc etc FW cord-303322-d69o3z8d 188 46 ) ) -RRB- cord-303322-d69o3z8d 188 47 . . . cord-303322-d69o3z8d 189 1 Should Should MD cord-303322-d69o3z8d 189 2 baseline baseline JJ cord-303322-d69o3z8d 189 3 data datum NNS cord-303322-d69o3z8d 189 4 differ differ VBP cord-303322-d69o3z8d 189 5 between between IN cord-303322-d69o3z8d 189 6 groups group NNS cord-303322-d69o3z8d 189 7 , , , cord-303322-d69o3z8d 189 8 regression regression NN cord-303322-d69o3z8d 189 9 will will MD cord-303322-d69o3z8d 189 10 be be VB cord-303322-d69o3z8d 189 11 used use VBN cord-303322-d69o3z8d 189 12 to to TO cord-303322-d69o3z8d 189 13 check check VB cord-303322-d69o3z8d 189 14 that that IN cord-303322-d69o3z8d 189 15 the the DT cord-303322-d69o3z8d 189 16 primary primary JJ cord-303322-d69o3z8d 189 17 outcomes outcome NNS cord-303322-d69o3z8d 189 18 are be VBP cord-303322-d69o3z8d 189 19 not not RB cord-303322-d69o3z8d 189 20 affected affect VBN cord-303322-d69o3z8d 189 21 by by IN cord-303322-d69o3z8d 189 22 this this DT cord-303322-d69o3z8d 189 23 chance chance NN cord-303322-d69o3z8d 189 24 finding finding NN cord-303322-d69o3z8d 189 25 . . . cord-303322-d69o3z8d 190 1 An an DT cord-303322-d69o3z8d 190 2 a a RB cord-303322-d69o3z8d 190 3 - - HYPH cord-303322-d69o3z8d 190 4 priori priori FW cord-303322-d69o3z8d 190 5 sub sub NN cord-303322-d69o3z8d 190 6 - - NN cord-303322-d69o3z8d 190 7 analysis analysis NN cord-303322-d69o3z8d 190 8 will will MD cord-303322-d69o3z8d 190 9 compare compare VB cord-303322-d69o3z8d 190 10 infants infant NNS cord-303322-d69o3z8d 190 11 aged age VBN cord-303322-d69o3z8d 190 12 ≤ ≤ NNS cord-303322-d69o3z8d 190 13 6months 6months CD cord-303322-d69o3z8d 190 14 with with IN cord-303322-d69o3z8d 190 15 those those DT cord-303322-d69o3z8d 190 16 aged age VBN cord-303322-d69o3z8d 190 17 > > XX cord-303322-d69o3z8d 190 18 6-months 6-months CD cord-303322-d69o3z8d 190 19 . . . cord-303322-d69o3z8d 191 1 When when WRB cord-303322-d69o3z8d 191 2 examining examine VBG cord-303322-d69o3z8d 191 3 the the DT cord-303322-d69o3z8d 191 4 efficacy efficacy NN cord-303322-d69o3z8d 191 5 of of IN cord-303322-d69o3z8d 191 6 azithromycin azithromycin NN cord-303322-d69o3z8d 191 7 at at IN cord-303322-d69o3z8d 191 8 reducing reduce VBG cord-303322-d69o3z8d 191 9 readmission readmission NN cord-303322-d69o3z8d 191 10 rate rate NN cord-303322-d69o3z8d 191 11 for for IN cord-303322-d69o3z8d 191 12 respiratory respiratory JJ cord-303322-d69o3z8d 191 13 illness illness NN cord-303322-d69o3z8d 191 14 ( ( -LRB- cord-303322-d69o3z8d 191 15 Secondary secondary JJ cord-303322-d69o3z8d 191 16 Aim-2 Aim-2 NNP cord-303322-d69o3z8d 191 17 ) ) -RRB- cord-303322-d69o3z8d 191 18 , , , cord-303322-d69o3z8d 191 19 the the DT cord-303322-d69o3z8d 191 20 Odds Odds NNPS cord-303322-d69o3z8d 191 21 Ratio Ratio NNP cord-303322-d69o3z8d 191 22 ( ( -LRB- cord-303322-d69o3z8d 191 23 OR OR NNP cord-303322-d69o3z8d 191 24 ) ) -RRB- cord-303322-d69o3z8d 191 25 between between IN cord-303322-d69o3z8d 191 26 groups group NNS cord-303322-d69o3z8d 191 27 will will MD cord-303322-d69o3z8d 191 28 be be VB cord-303322-d69o3z8d 191 29 calculated calculate VBN cord-303322-d69o3z8d 191 30 . . . cord-303322-d69o3z8d 192 1 The the DT cord-303322-d69o3z8d 192 2 OR OR NNP cord-303322-d69o3z8d 192 3 will will MD cord-303322-d69o3z8d 192 4 also also RB cord-303322-d69o3z8d 192 5 be be VB cord-303322-d69o3z8d 192 6 used use VBN cord-303322-d69o3z8d 192 7 to to TO cord-303322-d69o3z8d 192 8 compare compare VB cord-303322-d69o3z8d 192 9 additional additional JJ cord-303322-d69o3z8d 192 10 antibiotic antibiotic JJ cord-303322-d69o3z8d 192 11 use use NN cord-303322-d69o3z8d 192 12 between between IN cord-303322-d69o3z8d 192 13 groups group NNS cord-303322-d69o3z8d 192 14 . . . cord-303322-d69o3z8d 193 1 The the DT cord-303322-d69o3z8d 193 2 number number NN cord-303322-d69o3z8d 193 3 needed need VBN cord-303322-d69o3z8d 193 4 to to TO cord-303322-d69o3z8d 193 5 treat treat VB cord-303322-d69o3z8d 193 6 ( ( -LRB- cord-303322-d69o3z8d 193 7 NNT NNT NNP cord-303322-d69o3z8d 193 8 ) ) -RRB- cord-303322-d69o3z8d 193 9 ( ( -LRB- cord-303322-d69o3z8d 193 10 for for IN cord-303322-d69o3z8d 193 11 benefit benefit NN cord-303322-d69o3z8d 193 12 ) ) -RRB- cord-303322-d69o3z8d 193 13 , , , cord-303322-d69o3z8d 193 14 95 95 CD cord-303322-d69o3z8d 193 15 % % NN cord-303322-d69o3z8d 193 16 CI CI NNP cord-303322-d69o3z8d 193 17 will will MD cord-303322-d69o3z8d 193 18 be be VB cord-303322-d69o3z8d 193 19 described describe VBN cord-303322-d69o3z8d 193 20 if if IN cord-303322-d69o3z8d 193 21 any any DT cord-303322-d69o3z8d 193 22 significant significant JJ cord-303322-d69o3z8d 193 23 differences difference NNS cord-303322-d69o3z8d 193 24 are be VBP cord-303322-d69o3z8d 193 25 found find VBN cord-303322-d69o3z8d 193 26 . . . cord-303322-d69o3z8d 194 1 If if IN cord-303322-d69o3z8d 194 2 significant significant JJ cord-303322-d69o3z8d 194 3 , , , cord-303322-d69o3z8d 194 4 NNT NNT NNP cord-303322-d69o3z8d 194 5 for for IN cord-303322-d69o3z8d 194 6 harm harm NN cord-303322-d69o3z8d 194 7 will will MD cord-303322-d69o3z8d 194 8 be be VB cord-303322-d69o3z8d 194 9 calculated calculate VBN cord-303322-d69o3z8d 194 10 for for IN cord-303322-d69o3z8d 194 11 adverse adverse JJ cord-303322-d69o3z8d 194 12 events event NNS cord-303322-d69o3z8d 194 13 . . . cord-303322-d69o3z8d 195 1 For for IN cord-303322-d69o3z8d 195 2 Secondary Secondary NNP cord-303322-d69o3z8d 195 3 Aim-3 Aim-3 NNP cord-303322-d69o3z8d 195 4 ( ( -LRB- cord-303322-d69o3z8d 195 5 short short JJ cord-303322-d69o3z8d 195 6 - - HYPH cord-303322-d69o3z8d 195 7 term term NN cord-303322-d69o3z8d 195 8 impact impact NN cord-303322-d69o3z8d 195 9 of of IN cord-303322-d69o3z8d 195 10 azithromycin azithromycin NN cord-303322-d69o3z8d 195 11 on on IN cord-303322-d69o3z8d 195 12 macrolide macrolide NN cord-303322-d69o3z8d 195 13 - - HYPH cord-303322-d69o3z8d 195 14 resistance resistance NN cord-303322-d69o3z8d 195 15 of of IN cord-303322-d69o3z8d 195 16 pathogens pathogen NNS cord-303322-d69o3z8d 195 17 in in IN cord-303322-d69o3z8d 195 18 NPS NPS NNP cord-303322-d69o3z8d 195 19 cultures culture NNS cord-303322-d69o3z8d 195 20 ) ) -RRB- cord-303322-d69o3z8d 195 21 : : : cord-303322-d69o3z8d 195 22 the the DT cord-303322-d69o3z8d 195 23 proportions proportion NNS cord-303322-d69o3z8d 195 24 of of IN cord-303322-d69o3z8d 195 25 children child NNS cord-303322-d69o3z8d 195 26 with with IN cord-303322-d69o3z8d 195 27 penicillinnon penicillinnon NN cord-303322-d69o3z8d 195 28 - - JJ cord-303322-d69o3z8d 195 29 susceptible susceptible JJ cord-303322-d69o3z8d 195 30 S. S. NNP cord-303322-d69o3z8d 195 31 pneumoniae pneumoniae NN cord-303322-d69o3z8d 195 32 and and CC cord-303322-d69o3z8d 195 33 macrolide macrolide NN cord-303322-d69o3z8d 195 34 - - HYPH cord-303322-d69o3z8d 195 35 resistant resistant JJ cord-303322-d69o3z8d 195 36 H. h. NN cord-303322-d69o3z8d 195 37 influenzae influenzae NN cord-303322-d69o3z8d 195 38 spp spp NN cord-303322-d69o3z8d 195 39 and and CC cord-303322-d69o3z8d 195 40 M. M. NNP cord-303322-d69o3z8d 195 41 catarrhalis catarrhalis NNP cord-303322-d69o3z8d 195 42 before before IN cord-303322-d69o3z8d 195 43 and and CC cord-303322-d69o3z8d 195 44 after after IN cord-303322-d69o3z8d 195 45 trial trial NN cord-303322-d69o3z8d 195 46 medications medication NNS cord-303322-d69o3z8d 195 47 will will MD cord-303322-d69o3z8d 195 48 be be VB cord-303322-d69o3z8d 195 49 compared compare VBN cord-303322-d69o3z8d 195 50 using use VBG cord-303322-d69o3z8d 195 51 ORs or NNS cord-303322-d69o3z8d 195 52 and and CC cord-303322-d69o3z8d 195 53 95 95 CD cord-303322-d69o3z8d 195 54 % % NN cord-303322-d69o3z8d 195 55 CI CI NNP cord-303322-d69o3z8d 195 56 . . . cord-303322-d69o3z8d 196 1 Descriptive descriptive JJ cord-303322-d69o3z8d 196 2 data datum NNS cord-303322-d69o3z8d 196 3 will will MD cord-303322-d69o3z8d 196 4 be be VB cord-303322-d69o3z8d 196 5 utilised utilise VBN cord-303322-d69o3z8d 196 6 for for IN cord-303322-d69o3z8d 196 7 Secondary Secondary NNP cord-303322-d69o3z8d 196 8 Aim-4 Aim-4 NNP cord-303322-d69o3z8d 196 9 ( ( -LRB- cord-303322-d69o3z8d 196 10 point point NN cord-303322-d69o3z8d 196 11 prevalence prevalence NN cord-303322-d69o3z8d 196 12 of of IN cord-303322-d69o3z8d 196 13 respiratory respiratory JJ cord-303322-d69o3z8d 196 14 viruses virus NNS cord-303322-d69o3z8d 196 15 and and CC cord-303322-d69o3z8d 196 16 other other JJ cord-303322-d69o3z8d 196 17 respiratory respiratory JJ cord-303322-d69o3z8d 196 18 pathogens pathogen NNS cord-303322-d69o3z8d 196 19 ) ) -RRB- cord-303322-d69o3z8d 196 20 . . . cord-303322-d69o3z8d 197 1 The the DT cord-303322-d69o3z8d 197 2 _SP cord-303322-d69o3z8d 197 3 Acute Acute NNP cord-303322-d69o3z8d 197 4 lower low JJR cord-303322-d69o3z8d 197 5 respiratory respiratory JJ cord-303322-d69o3z8d 197 6 tract tract NN cord-303322-d69o3z8d 197 7 infections infection NNS cord-303322-d69o3z8d 197 8 are be VBP cord-303322-d69o3z8d 197 9 the the DT cord-303322-d69o3z8d 197 10 commonest common JJS cord-303322-d69o3z8d 197 11 cause cause NN cord-303322-d69o3z8d 197 12 of of IN cord-303322-d69o3z8d 197 13 hospitalisation hospitalisation NN cord-303322-d69o3z8d 197 14 and and CC cord-303322-d69o3z8d 197 15 potentially potentially RB cord-303322-d69o3z8d 197 16 preventable preventable JJ cord-303322-d69o3z8d 197 17 deaths death NNS cord-303322-d69o3z8d 197 18 in in IN cord-303322-d69o3z8d 197 19 Indigenous indigenous JJ cord-303322-d69o3z8d 197 20 infants infant NNS cord-303322-d69o3z8d 197 21 [ [ -LRB- cord-303322-d69o3z8d 197 22 4 4 CD cord-303322-d69o3z8d 197 23 ] ] -RRB- cord-303322-d69o3z8d 197 24 . . . cord-303322-d69o3z8d 198 1 Bronchiolitis Bronchiolitis NNP cord-303322-d69o3z8d 198 2 in in IN cord-303322-d69o3z8d 198 3 Indigenous indigenous JJ cord-303322-d69o3z8d 198 4 infants infant NNS cord-303322-d69o3z8d 198 5 is be VBZ cord-303322-d69o3z8d 198 6 more more RBR cord-303322-d69o3z8d 198 7 severe severe JJ cord-303322-d69o3z8d 198 8 than than IN cord-303322-d69o3z8d 198 9 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 198 10 in in IN cord-303322-d69o3z8d 198 11 non non JJ cord-303322-d69o3z8d 198 12 - - JJ cord-303322-d69o3z8d 198 13 Indigenous indigenous JJ cord-303322-d69o3z8d 198 14 infants infant NNS cord-303322-d69o3z8d 198 15 [ [ -LRB- cord-303322-d69o3z8d 198 16 6 6 CD cord-303322-d69o3z8d 198 17 ] ] -RRB- cord-303322-d69o3z8d 198 18 . . . cord-303322-d69o3z8d 199 1 There there EX cord-303322-d69o3z8d 199 2 are be VBP cord-303322-d69o3z8d 199 3 higher high JJR cord-303322-d69o3z8d 199 4 readmission readmission NN cord-303322-d69o3z8d 199 5 rates rate NNS cord-303322-d69o3z8d 199 6 and and CC cord-303322-d69o3z8d 199 7 an an DT cord-303322-d69o3z8d 199 8 increased increase VBN cord-303322-d69o3z8d 199 9 risk risk NN cord-303322-d69o3z8d 199 10 of of IN cord-303322-d69o3z8d 199 11 ongoing ongoing JJ cord-303322-d69o3z8d 199 12 respiratory respiratory JJ cord-303322-d69o3z8d 199 13 morbidity morbidity NN cord-303322-d69o3z8d 199 14 ( ( -LRB- cord-303322-d69o3z8d 199 15 including include VBG cord-303322-d69o3z8d 199 16 chronic chronic JJ cord-303322-d69o3z8d 199 17 suppurative suppurative JJ cord-303322-d69o3z8d 199 18 lung lung NN cord-303322-d69o3z8d 199 19 disease disease NN cord-303322-d69o3z8d 199 20 ) ) -RRB- cord-303322-d69o3z8d 199 21 in in IN cord-303322-d69o3z8d 199 22 Indigenous indigenous JJ cord-303322-d69o3z8d 199 23 infants infant NNS cord-303322-d69o3z8d 199 24 [ [ -LRB- cord-303322-d69o3z8d 199 25 7 7 CD cord-303322-d69o3z8d 199 26 , , , cord-303322-d69o3z8d 199 27 41 41 CD cord-303322-d69o3z8d 199 28 ] ] -RRB- cord-303322-d69o3z8d 199 29 . . . cord-303322-d69o3z8d 200 1 This this DT cord-303322-d69o3z8d 200 2 may may MD cord-303322-d69o3z8d 200 3 be be VB cord-303322-d69o3z8d 200 4 due due JJ cord-303322-d69o3z8d 200 5 to to IN cord-303322-d69o3z8d 200 6 an an DT cord-303322-d69o3z8d 200 7 increased increase VBN cord-303322-d69o3z8d 200 8 likelihood likelihood NN cord-303322-d69o3z8d 200 9 of of IN cord-303322-d69o3z8d 200 10 recurrent recurrent JJ cord-303322-d69o3z8d 200 11 infections infection NNS cord-303322-d69o3z8d 200 12 and and CC cord-303322-d69o3z8d 200 13 virusbacteria virusbacteria NN cord-303322-d69o3z8d 200 14 interactions interaction NNS cord-303322-d69o3z8d 200 15 from from IN cord-303322-d69o3z8d 200 16 an an DT cord-303322-d69o3z8d 200 17 early early JJ cord-303322-d69o3z8d 200 18 age age NN cord-303322-d69o3z8d 200 19 ( ( -LRB- cord-303322-d69o3z8d 200 20 as as RB cord-303322-d69o3z8d 200 21 early early RB cord-303322-d69o3z8d 200 22 as as IN cord-303322-d69o3z8d 200 23 aged aged JJ cord-303322-d69o3z8d 200 24 2-wks 2-wks CD cord-303322-d69o3z8d 200 25 ) ) -RRB- cord-303322-d69o3z8d 200 26 along along IN cord-303322-d69o3z8d 200 27 with with IN cord-303322-d69o3z8d 200 28 heavy heavy JJ cord-303322-d69o3z8d 200 29 bacterial bacterial JJ cord-303322-d69o3z8d 200 30 colonisation colonisation NN cord-303322-d69o3z8d 200 31 of of IN cord-303322-d69o3z8d 200 32 the the DT cord-303322-d69o3z8d 200 33 nasopharynx nasopharynx NN cord-303322-d69o3z8d 200 34 [ [ -LRB- cord-303322-d69o3z8d 200 35 36 36 CD cord-303322-d69o3z8d 200 36 ] ] -RRB- cord-303322-d69o3z8d 200 37 . . . cord-303322-d69o3z8d 201 1 Despite despite IN cord-303322-d69o3z8d 201 2 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 201 3 being be VBG cord-303322-d69o3z8d 201 4 the the DT cord-303322-d69o3z8d 201 5 most most RBS cord-303322-d69o3z8d 201 6 common common JJ cord-303322-d69o3z8d 201 7 cause cause NN cord-303322-d69o3z8d 201 8 of of IN cord-303322-d69o3z8d 201 9 ALRIs alri NNS cord-303322-d69o3z8d 201 10 in in IN cord-303322-d69o3z8d 201 11 infants infant NNS cord-303322-d69o3z8d 201 12 resulting result VBG cord-303322-d69o3z8d 201 13 in in IN cord-303322-d69o3z8d 201 14 hospitalisation hospitalisation NN cord-303322-d69o3z8d 201 15 , , , cord-303322-d69o3z8d 201 16 there there EX cord-303322-d69o3z8d 201 17 are be VBP cord-303322-d69o3z8d 201 18 no no DT cord-303322-d69o3z8d 201 19 published publish VBN cord-303322-d69o3z8d 201 20 prospective prospective JJ cord-303322-d69o3z8d 201 21 studies study NNS cord-303322-d69o3z8d 201 22 of of IN cord-303322-d69o3z8d 201 23 this this DT cord-303322-d69o3z8d 201 24 illness illness NN cord-303322-d69o3z8d 201 25 in in IN cord-303322-d69o3z8d 201 26 Australian australian JJ cord-303322-d69o3z8d 201 27 Indigenous indigenous JJ cord-303322-d69o3z8d 201 28 infants infant NNS cord-303322-d69o3z8d 201 29 . . . cord-303322-d69o3z8d 202 1 Two two CD cord-303322-d69o3z8d 202 2 small small JJ cord-303322-d69o3z8d 202 3 clinical clinical JJ cord-303322-d69o3z8d 202 4 trials trial NNS cord-303322-d69o3z8d 202 5 have have VBP cord-303322-d69o3z8d 202 6 studied study VBN cord-303322-d69o3z8d 202 7 macrolides macrolide NNS cord-303322-d69o3z8d 202 8 in in IN cord-303322-d69o3z8d 202 9 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 202 10 , , , cord-303322-d69o3z8d 202 11 but but CC cord-303322-d69o3z8d 202 12 with with IN cord-303322-d69o3z8d 202 13 contradictory contradictory JJ cord-303322-d69o3z8d 202 14 results result NNS cord-303322-d69o3z8d 202 15 . . . cord-303322-d69o3z8d 203 1 Our -PRON- PRP$ cord-303322-d69o3z8d 203 2 population population NN cord-303322-d69o3z8d 203 3 setting setting NN cord-303322-d69o3z8d 203 4 is be VBZ cord-303322-d69o3z8d 203 5 more more RBR cord-303322-d69o3z8d 203 6 closely closely RB cord-303322-d69o3z8d 203 7 related related JJ cord-303322-d69o3z8d 203 8 to to IN cord-303322-d69o3z8d 203 9 the the DT cord-303322-d69o3z8d 203 10 Turkish turkish JJ cord-303322-d69o3z8d 203 11 study study NN cord-303322-d69o3z8d 203 12 [ [ -LRB- cord-303322-d69o3z8d 203 13 26 26 CD cord-303322-d69o3z8d 203 14 ] ] -RRB- cord-303322-d69o3z8d 203 15 where where WRB cord-303322-d69o3z8d 203 16 a a DT cord-303322-d69o3z8d 203 17 beneficial beneficial JJ cord-303322-d69o3z8d 203 18 effect effect NN cord-303322-d69o3z8d 203 19 for for IN cord-303322-d69o3z8d 203 20 macrolides macrolide NNS cord-303322-d69o3z8d 203 21 was be VBD cord-303322-d69o3z8d 203 22 shown show VBN cord-303322-d69o3z8d 203 23 . . . cord-303322-d69o3z8d 204 1 This this DT cord-303322-d69o3z8d 204 2 is be VBZ cord-303322-d69o3z8d 204 3 in in IN cord-303322-d69o3z8d 204 4 contrast contrast NN cord-303322-d69o3z8d 204 5 to to IN cord-303322-d69o3z8d 204 6 the the DT cord-303322-d69o3z8d 204 7 negative negative JJ cord-303322-d69o3z8d 204 8 findings finding NNS cord-303322-d69o3z8d 204 9 of of IN cord-303322-d69o3z8d 204 10 the the DT cord-303322-d69o3z8d 204 11 Dutch dutch JJ cord-303322-d69o3z8d 204 12 study study NN cord-303322-d69o3z8d 204 13 [ [ -LRB- cord-303322-d69o3z8d 204 14 27 27 CD cord-303322-d69o3z8d 204 15 ] ] -RRB- cord-303322-d69o3z8d 204 16 in in IN cord-303322-d69o3z8d 204 17 an an DT cord-303322-d69o3z8d 204 18 affluent affluent JJ cord-303322-d69o3z8d 204 19 urban urban JJ cord-303322-d69o3z8d 204 20 setting setting NN cord-303322-d69o3z8d 204 21 . . . cord-303322-d69o3z8d 205 1 Our -PRON- PRP$ cord-303322-d69o3z8d 205 2 proposed propose VBN cord-303322-d69o3z8d 205 3 double double JJ cord-303322-d69o3z8d 205 4 - - HYPH cord-303322-d69o3z8d 205 5 blind blind JJ cord-303322-d69o3z8d 205 6 RCT RCT NNP cord-303322-d69o3z8d 205 7 will will MD cord-303322-d69o3z8d 205 8 determine determine VB cord-303322-d69o3z8d 205 9 if if IN cord-303322-d69o3z8d 205 10 azithromycin azithromycin NNP cord-303322-d69o3z8d 205 11 is be VBZ cord-303322-d69o3z8d 205 12 an an DT cord-303322-d69o3z8d 205 13 effective effective JJ cord-303322-d69o3z8d 205 14 additional additional JJ cord-303322-d69o3z8d 205 15 treatment treatment NN cord-303322-d69o3z8d 205 16 in in IN cord-303322-d69o3z8d 205 17 Indigenous indigenous JJ cord-303322-d69o3z8d 205 18 infants infant NNS cord-303322-d69o3z8d 205 19 hospitalised hospitalise VBN cord-303322-d69o3z8d 205 20 with with IN cord-303322-d69o3z8d 205 21 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 205 22 . . . cord-303322-d69o3z8d 206 1 It -PRON- PRP cord-303322-d69o3z8d 206 2 will will MD cord-303322-d69o3z8d 206 3 also also RB cord-303322-d69o3z8d 206 4 determine determine VB cord-303322-d69o3z8d 206 5 whether whether IN cord-303322-d69o3z8d 206 6 in in IN cord-303322-d69o3z8d 206 7 the the DT cord-303322-d69o3z8d 206 8 ensuing ensue VBG cord-303322-d69o3z8d 206 9 6 6 CD cord-303322-d69o3z8d 206 10 months month NNS cord-303322-d69o3z8d 206 11 it -PRON- PRP cord-303322-d69o3z8d 206 12 will will MD cord-303322-d69o3z8d 206 13 prevent prevent VB cord-303322-d69o3z8d 206 14 hospital hospital NN cord-303322-d69o3z8d 206 15 readmissions readmission NNS cord-303322-d69o3z8d 206 16 from from IN cord-303322-d69o3z8d 206 17 respiratory respiratory JJ cord-303322-d69o3z8d 206 18 illnesses illness NNS cord-303322-d69o3z8d 206 19 , , , cord-303322-d69o3z8d 206 20 which which WDT cord-303322-d69o3z8d 206 21 potentially potentially RB cord-303322-d69o3z8d 206 22 reduces reduce VBZ cord-303322-d69o3z8d 206 23 the the DT cord-303322-d69o3z8d 206 24 likelihood likelihood NN cord-303322-d69o3z8d 206 25 of of IN cord-303322-d69o3z8d 206 26 chronic chronic JJ cord-303322-d69o3z8d 206 27 lung lung NN cord-303322-d69o3z8d 206 28 dysfunction dysfunction NN cord-303322-d69o3z8d 206 29 [ [ -LRB- cord-303322-d69o3z8d 206 30 7 7 CD cord-303322-d69o3z8d 206 31 ] ] -RRB- cord-303322-d69o3z8d 206 32 in in IN cord-303322-d69o3z8d 206 33 this this DT cord-303322-d69o3z8d 206 34 high high JJ cord-303322-d69o3z8d 206 35 - - HYPH cord-303322-d69o3z8d 206 36 risk risk NN cord-303322-d69o3z8d 206 37 population population NN cord-303322-d69o3z8d 206 38 . . . cord-303322-d69o3z8d 207 1 Azithromycin Azithromycin NNP cord-303322-d69o3z8d 207 2 was be VBD cord-303322-d69o3z8d 207 3 chosen choose VBN cord-303322-d69o3z8d 207 4 over over IN cord-303322-d69o3z8d 207 5 other other JJ cord-303322-d69o3z8d 207 6 macrolides macrolide NNS cord-303322-d69o3z8d 207 7 because because IN cord-303322-d69o3z8d 207 8 of of IN cord-303322-d69o3z8d 207 9 its -PRON- PRP$ cord-303322-d69o3z8d 207 10 prompt prompt JJ cord-303322-d69o3z8d 207 11 and and CC cord-303322-d69o3z8d 207 12 potent potent JJ cord-303322-d69o3z8d 207 13 anti anti JJ cord-303322-d69o3z8d 207 14 - - JJ cord-303322-d69o3z8d 207 15 inflammatory inflammatory JJ cord-303322-d69o3z8d 207 16 effects effect NNS cord-303322-d69o3z8d 207 17 as as RB cord-303322-d69o3z8d 207 18 well well RB cord-303322-d69o3z8d 207 19 as as IN cord-303322-d69o3z8d 207 20 its -PRON- PRP$ cord-303322-d69o3z8d 207 21 30 30 CD cord-303322-d69o3z8d 207 22 - - SYM cord-303322-d69o3z8d 207 23 40 40 CD cord-303322-d69o3z8d 207 24 hours hour NNS cord-303322-d69o3z8d 207 25 half half JJ cord-303322-d69o3z8d 207 26 - - HYPH cord-303322-d69o3z8d 207 27 life life NN cord-303322-d69o3z8d 207 28 in in IN cord-303322-d69o3z8d 207 29 children child NNS cord-303322-d69o3z8d 207 30 , , , cord-303322-d69o3z8d 207 31 which which WDT cord-303322-d69o3z8d 207 32 permits permit VBZ cord-303322-d69o3z8d 207 33 once once RB cord-303322-d69o3z8d 207 34 weekly weekly JJ cord-303322-d69o3z8d 207 35 dosing dose VBG cord-303322-d69o3z8d 207 36 [ [ -LRB- cord-303322-d69o3z8d 207 37 42 42 CD cord-303322-d69o3z8d 207 38 ] ] -RRB- cord-303322-d69o3z8d 207 39 . . . cord-303322-d69o3z8d 208 1 The the DT cord-303322-d69o3z8d 208 2 possible possible JJ cord-303322-d69o3z8d 208 3 anti anti JJ cord-303322-d69o3z8d 208 4 - - JJ cord-303322-d69o3z8d 208 5 viral viral JJ cord-303322-d69o3z8d 208 6 effects effect NNS cord-303322-d69o3z8d 208 7 is be VBZ cord-303322-d69o3z8d 208 8 also also RB cord-303322-d69o3z8d 208 9 attractive attractive JJ cord-303322-d69o3z8d 208 10 [ [ -LRB- cord-303322-d69o3z8d 208 11 43 43 CD cord-303322-d69o3z8d 208 12 ] ] -RRB- cord-303322-d69o3z8d 208 13 . . . cord-303322-d69o3z8d 209 1 An an DT cord-303322-d69o3z8d 209 2 important important JJ cord-303322-d69o3z8d 209 3 safety safety NN cord-303322-d69o3z8d 209 4 component component NN cord-303322-d69o3z8d 209 5 of of IN cord-303322-d69o3z8d 209 6 the the DT cord-303322-d69o3z8d 209 7 current current JJ cord-303322-d69o3z8d 209 8 study study NN cord-303322-d69o3z8d 209 9 is be VBZ cord-303322-d69o3z8d 209 10 to to TO cord-303322-d69o3z8d 209 11 monitor monitor VB cord-303322-d69o3z8d 209 12 for for IN cord-303322-d69o3z8d 209 13 antibiotic antibiotic JJ cord-303322-d69o3z8d 209 14 resistance resistance NN cord-303322-d69o3z8d 209 15 in in IN cord-303322-d69o3z8d 209 16 potential potential JJ cord-303322-d69o3z8d 209 17 respiratory respiratory JJ cord-303322-d69o3z8d 209 18 bacterial bacterial JJ cord-303322-d69o3z8d 209 19 pathogens pathogen NNS cord-303322-d69o3z8d 209 20 colonising colonise VBG cord-303322-d69o3z8d 209 21 the the DT cord-303322-d69o3z8d 209 22 nasopharynx nasopharynx NN cord-303322-d69o3z8d 209 23 . . . cord-303322-d69o3z8d 210 1 For for IN cord-303322-d69o3z8d 210 2 the the DT cord-303322-d69o3z8d 210 3 first first JJ cord-303322-d69o3z8d 210 4 time time NN cord-303322-d69o3z8d 210 5 in in IN cord-303322-d69o3z8d 210 6 this this DT cord-303322-d69o3z8d 210 7 population population NN cord-303322-d69o3z8d 210 8 , , , cord-303322-d69o3z8d 210 9 we -PRON- PRP cord-303322-d69o3z8d 210 10 will will MD cord-303322-d69o3z8d 210 11 determine determine VB cord-303322-d69o3z8d 210 12 the the DT cord-303322-d69o3z8d 210 13 nature nature NN cord-303322-d69o3z8d 210 14 and and CC cord-303322-d69o3z8d 210 15 diversity diversity NN cord-303322-d69o3z8d 210 16 of of IN cord-303322-d69o3z8d 210 17 respiratory respiratory JJ cord-303322-d69o3z8d 210 18 viruses virus NNS cord-303322-d69o3z8d 210 19 , , , cord-303322-d69o3z8d 210 20 Mycoplasma Mycoplasma NNP cord-303322-d69o3z8d 210 21 , , , cord-303322-d69o3z8d 210 22 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 210 23 and and CC cord-303322-d69o3z8d 210 24 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 210 25 - - HYPH cord-303322-d69o3z8d 210 26 like like JJ cord-303322-d69o3z8d 210 27 species specie NNS cord-303322-d69o3z8d 210 28 in in IN cord-303322-d69o3z8d 210 29 association association NN cord-303322-d69o3z8d 210 30 with with IN cord-303322-d69o3z8d 210 31 cases case NNS cord-303322-d69o3z8d 210 32 of of IN cord-303322-d69o3z8d 210 33 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 210 34 requiring require VBG cord-303322-d69o3z8d 210 35 hospital hospital NN cord-303322-d69o3z8d 210 36 admission admission NN cord-303322-d69o3z8d 210 37 . . . cord-303322-d69o3z8d 211 1 The the DT cord-303322-d69o3z8d 211 2 range range NN cord-303322-d69o3z8d 211 3 of of IN cord-303322-d69o3z8d 211 4 organisms organism NNS cord-303322-d69o3z8d 211 5 includes include VBZ cord-303322-d69o3z8d 211 6 newly newly RB cord-303322-d69o3z8d 211 7 discovered discover VBN cord-303322-d69o3z8d 211 8 viruses virus NNS cord-303322-d69o3z8d 211 9 , , , cord-303322-d69o3z8d 211 10 [ [ -LRB- cord-303322-d69o3z8d 211 11 44 44 CD cord-303322-d69o3z8d 211 12 ] ] -RRB- cord-303322-d69o3z8d 211 13 and and CC cord-303322-d69o3z8d 211 14 treatable treatable JJ cord-303322-d69o3z8d 211 15 bacteria bacteria NNS cord-303322-d69o3z8d 211 16 that that WDT cord-303322-d69o3z8d 211 17 may may MD cord-303322-d69o3z8d 211 18 contribute contribute VB cord-303322-d69o3z8d 211 19 to to IN cord-303322-d69o3z8d 211 20 chronic chronic JJ cord-303322-d69o3z8d 211 21 lung lung NN cord-303322-d69o3z8d 211 22 dysfunction dysfunction NN cord-303322-d69o3z8d 211 23 . . . cord-303322-d69o3z8d 212 1 M. M. NNP cord-303322-d69o3z8d 212 2 pneumoniae pneumoniae NN cord-303322-d69o3z8d 212 3 and and CC cord-303322-d69o3z8d 212 4 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 212 5 species specie NNS cord-303322-d69o3z8d 212 6 are be VBP cord-303322-d69o3z8d 212 7 increasingly increasingly RB cord-303322-d69o3z8d 212 8 recognised recognise VBN cord-303322-d69o3z8d 212 9 as as IN cord-303322-d69o3z8d 212 10 important important JJ cord-303322-d69o3z8d 212 11 contributors contributor NNS cord-303322-d69o3z8d 212 12 to to IN cord-303322-d69o3z8d 212 13 development development NN cord-303322-d69o3z8d 212 14 of of IN cord-303322-d69o3z8d 212 15 chronic chronic JJ cord-303322-d69o3z8d 212 16 lung lung NN cord-303322-d69o3z8d 212 17 disease disease NN cord-303322-d69o3z8d 212 18 and and CC cord-303322-d69o3z8d 212 19 altered altered JJ cord-303322-d69o3z8d 212 20 lung lung NN cord-303322-d69o3z8d 212 21 maturation maturation NN cord-303322-d69o3z8d 212 22 [ [ -LRB- cord-303322-d69o3z8d 212 23 16 16 CD cord-303322-d69o3z8d 212 24 ] ] -RRB- cord-303322-d69o3z8d 212 25 [ [ -LRB- cord-303322-d69o3z8d 212 26 17 17 CD cord-303322-d69o3z8d 212 27 ] ] -RRB- cord-303322-d69o3z8d 212 28 [ [ -LRB- cord-303322-d69o3z8d 212 29 18 18 CD cord-303322-d69o3z8d 212 30 ] ] -RRB- cord-303322-d69o3z8d 212 31 [ [ -LRB- cord-303322-d69o3z8d 212 32 19 19 CD cord-303322-d69o3z8d 212 33 ] ] -RRB- cord-303322-d69o3z8d 212 34 . . . cord-303322-d69o3z8d 213 1 Our -PRON- PRP$ cord-303322-d69o3z8d 213 2 study study NN cord-303322-d69o3z8d 213 3 addresses address VBZ cord-303322-d69o3z8d 213 4 a a DT cord-303322-d69o3z8d 213 5 large large JJ cord-303322-d69o3z8d 213 6 clinical clinical JJ cord-303322-d69o3z8d 213 7 research research NN cord-303322-d69o3z8d 213 8 gap gap NN cord-303322-d69o3z8d 213 9 for for IN cord-303322-d69o3z8d 213 10 an an DT cord-303322-d69o3z8d 213 11 important important JJ cord-303322-d69o3z8d 213 12 and and CC cord-303322-d69o3z8d 213 13 common common JJ cord-303322-d69o3z8d 213 14 cause cause NN cord-303322-d69o3z8d 213 15 of of IN cord-303322-d69o3z8d 213 16 hospitalisation hospitalisation NN cord-303322-d69o3z8d 213 17 in in IN cord-303322-d69o3z8d 213 18 Indigenous indigenous JJ cord-303322-d69o3z8d 213 19 infants infant NNS cord-303322-d69o3z8d 213 20 . . . cord-303322-d69o3z8d 214 1 If if IN cord-303322-d69o3z8d 214 2 the the DT cord-303322-d69o3z8d 214 3 intervention intervention NN cord-303322-d69o3z8d 214 4 is be VBZ cord-303322-d69o3z8d 214 5 successful successful JJ cord-303322-d69o3z8d 214 6 , , , cord-303322-d69o3z8d 214 7 it -PRON- PRP cord-303322-d69o3z8d 214 8 would would MD cord-303322-d69o3z8d 214 9 lead lead VB cord-303322-d69o3z8d 214 10 to to IN cord-303322-d69o3z8d 214 11 improved improve VBN cord-303322-d69o3z8d 214 12 short short JJ cord-303322-d69o3z8d 214 13 term term NN cord-303322-d69o3z8d 214 14 ( ( -LRB- cord-303322-d69o3z8d 214 15 and and CC cord-303322-d69o3z8d 214 16 possibly possibly RB cord-303322-d69o3z8d 214 17 long long JJ cord-303322-d69o3z8d 214 18 term term NN cord-303322-d69o3z8d 214 19 ) ) -RRB- cord-303322-d69o3z8d 214 20 health health NN cord-303322-d69o3z8d 214 21 benefits benefit NNS cord-303322-d69o3z8d 214 22 . . . cord-303322-d69o3z8d 215 1 Conclusive conclusive JJ cord-303322-d69o3z8d 215 2 results result NNS cord-303322-d69o3z8d 215 3 would would MD cord-303322-d69o3z8d 215 4 produce produce VB cord-303322-d69o3z8d 215 5 changes change NNS cord-303322-d69o3z8d 215 6 to to IN cord-303322-d69o3z8d 215 7 evidencebased evidencebased JJ cord-303322-d69o3z8d 215 8 standard standard JJ cord-303322-d69o3z8d 215 9 treatment treatment NN cord-303322-d69o3z8d 215 10 guidelines guideline NNS cord-303322-d69o3z8d 215 11 in in IN cord-303322-d69o3z8d 215 12 our -PRON- PRP$ cord-303322-d69o3z8d 215 13 region region NN cord-303322-d69o3z8d 215 14 and and CC cord-303322-d69o3z8d 215 15 those those DT cord-303322-d69o3z8d 215 16 produced produce VBN cord-303322-d69o3z8d 215 17 for for IN cord-303322-d69o3z8d 215 18 similar similar JJ cord-303322-d69o3z8d 215 19 populations population NNS cord-303322-d69o3z8d 215 20 nationally nationally RB cord-303322-d69o3z8d 215 21 and and CC cord-303322-d69o3z8d 215 22 internationally internationally RB cord-303322-d69o3z8d 215 23 . . . cord-303322-d69o3z8d 216 1 Finally finally RB cord-303322-d69o3z8d 216 2 , , , cord-303322-d69o3z8d 216 3 the the DT cord-303322-d69o3z8d 216 4 intervention intervention NN cord-303322-d69o3z8d 216 5 would would MD cord-303322-d69o3z8d 216 6 also also RB cord-303322-d69o3z8d 216 7 offer offer VB cord-303322-d69o3z8d 216 8 the the DT cord-303322-d69o3z8d 216 9 possibility possibility NN cord-303322-d69o3z8d 216 10 of of IN cord-303322-d69o3z8d 216 11 preventing prevent VBG cord-303322-d69o3z8d 216 12 ( ( -LRB- cord-303322-d69o3z8d 216 13 or or CC cord-303322-d69o3z8d 216 14 reducing reduce VBG cord-303322-d69o3z8d 216 15 ) ) -RRB- cord-303322-d69o3z8d 216 16 the the DT cord-303322-d69o3z8d 216 17 high high JJ cord-303322-d69o3z8d 216 18 rates rate NNS cord-303322-d69o3z8d 216 19 of of IN cord-303322-d69o3z8d 216 20 long long JJ cord-303322-d69o3z8d 216 21 - - HYPH cord-303322-d69o3z8d 216 22 term term NN cord-303322-d69o3z8d 216 23 respiratory respiratory JJ cord-303322-d69o3z8d 216 24 dysfunction dysfunction NN cord-303322-d69o3z8d 216 25 seen see VBN cord-303322-d69o3z8d 216 26 in in IN cord-303322-d69o3z8d 216 27 Australian australian JJ cord-303322-d69o3z8d 216 28 Indigenous indigenous JJ cord-303322-d69o3z8d 216 29 children child NNS cord-303322-d69o3z8d 216 30 and and CC cord-303322-d69o3z8d 216 31 adults adult NNS cord-303322-d69o3z8d 216 32 . . . cord-303322-d69o3z8d 217 1 Risk risk NN cord-303322-d69o3z8d 217 2 factors factor NNS cord-303322-d69o3z8d 217 3 for for IN cord-303322-d69o3z8d 217 4 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 217 5 in in IN cord-303322-d69o3z8d 217 6 Indigenous indigenous JJ cord-303322-d69o3z8d 217 7 children child NNS cord-303322-d69o3z8d 217 8 include include VBP cord-303322-d69o3z8d 217 9 recurrent recurrent JJ cord-303322-d69o3z8d 217 10 hospitalisation hospitalisation NN cord-303322-d69o3z8d 217 11 for for IN cord-303322-d69o3z8d 217 12 ALRIs alri NNS cord-303322-d69o3z8d 217 13 and and CC cord-303322-d69o3z8d 217 14 severity severity NN cord-303322-d69o3z8d 217 15 of of IN cord-303322-d69o3z8d 217 16 previous previous JJ cord-303322-d69o3z8d 217 17 ARLIs arli NNS cord-303322-d69o3z8d 217 18 ( ( -LRB- cord-303322-d69o3z8d 217 19 measured measure VBN cord-303322-d69o3z8d 217 20 by by IN cord-303322-d69o3z8d 217 21 duration duration NN cord-303322-d69o3z8d 217 22 of of IN cord-303322-d69o3z8d 217 23 stay stay NN cord-303322-d69o3z8d 217 24 and and CC cord-303322-d69o3z8d 217 25 requirement requirement NN cord-303322-d69o3z8d 217 26 for for IN cord-303322-d69o3z8d 217 27 oxygen oxygen NN cord-303322-d69o3z8d 217 28 supplementation supplementation NN cord-303322-d69o3z8d 217 29 during during IN cord-303322-d69o3z8d 217 30 hospitalisation hospitalisation NN cord-303322-d69o3z8d 217 31 ) ) -RRB- cord-303322-d69o3z8d 217 32 [ [ -LRB- cord-303322-d69o3z8d 217 33 7 7 CD cord-303322-d69o3z8d 217 34 ] ] -RRB- cord-303322-d69o3z8d 217 35 . . . cord-303322-d69o3z8d 218 1 In in IN cord-303322-d69o3z8d 218 2 the the DT cord-303322-d69o3z8d 218 3 context context NN cord-303322-d69o3z8d 218 4 of of IN cord-303322-d69o3z8d 218 5 the the DT cord-303322-d69o3z8d 218 6 high high JJ cord-303322-d69o3z8d 218 7 burden burden NN cord-303322-d69o3z8d 218 8 of of IN cord-303322-d69o3z8d 218 9 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 218 10 in in IN cord-303322-d69o3z8d 218 11 our -PRON- PRP$ cord-303322-d69o3z8d 218 12 setting setting NN cord-303322-d69o3z8d 218 13 , , , cord-303322-d69o3z8d 218 14 we -PRON- PRP cord-303322-d69o3z8d 218 15 considered consider VBD cord-303322-d69o3z8d 218 16 that that IN cord-303322-d69o3z8d 218 17 the the DT cord-303322-d69o3z8d 218 18 most most RBS cord-303322-d69o3z8d 218 19 important important JJ cord-303322-d69o3z8d 218 20 outcomes outcome NNS cord-303322-d69o3z8d 218 21 are be VBP cord-303322-d69o3z8d 218 22 LOS LOS NNP cord-303322-d69o3z8d 218 23 , , , cord-303322-d69o3z8d 218 24 requirement requirement NN cord-303322-d69o3z8d 218 25 for for IN cord-303322-d69o3z8d 218 26 oxygen oxygen NN cord-303322-d69o3z8d 218 27 supplementation supplementation NN cord-303322-d69o3z8d 218 28 during during IN cord-303322-d69o3z8d 218 29 hospitalisation hospitalisation NN cord-303322-d69o3z8d 218 30 and and CC cord-303322-d69o3z8d 218 31 readmission readmission NN cord-303322-d69o3z8d 218 32 within within IN cord-303322-d69o3z8d 218 33 a a DT cord-303322-d69o3z8d 218 34 6-month 6-month CD cord-303322-d69o3z8d 218 35 period period NN cord-303322-d69o3z8d 218 36 . . . cord-303322-d69o3z8d 219 1 Length length NN cord-303322-d69o3z8d 219 2 of of IN cord-303322-d69o3z8d 219 3 hospitalisation hospitalisation NN cord-303322-d69o3z8d 219 4 is be VBZ cord-303322-d69o3z8d 219 5 a a DT cord-303322-d69o3z8d 219 6 common common JJ cord-303322-d69o3z8d 219 7 outcome outcome NN cord-303322-d69o3z8d 219 8 measure measure NN cord-303322-d69o3z8d 219 9 in in IN cord-303322-d69o3z8d 219 10 studies study NNS cord-303322-d69o3z8d 219 11 on on IN cord-303322-d69o3z8d 219 12 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 219 13 . . . cord-303322-d69o3z8d 220 1 However however RB cord-303322-d69o3z8d 220 2 in in IN cord-303322-d69o3z8d 220 3 our -PRON- PRP$ cord-303322-d69o3z8d 220 4 setting setting NN cord-303322-d69o3z8d 220 5 , , , cord-303322-d69o3z8d 220 6 hospitalised hospitalise VBN cord-303322-d69o3z8d 220 7 children child NNS cord-303322-d69o3z8d 220 8 often often RB cord-303322-d69o3z8d 220 9 come come VBP cord-303322-d69o3z8d 220 10 from from IN cord-303322-d69o3z8d 220 11 remote remote JJ cord-303322-d69o3z8d 220 12 comunities comunitie NNS cord-303322-d69o3z8d 220 13 and and CC cord-303322-d69o3z8d 220 14 may may MD cord-303322-d69o3z8d 220 15 have have VB cord-303322-d69o3z8d 220 16 multiple multiple JJ cord-303322-d69o3z8d 220 17 co co NNS cord-303322-d69o3z8d 220 18 - - NNS cord-303322-d69o3z8d 220 19 morbidities morbidity NNS cord-303322-d69o3z8d 220 20 [ [ -LRB- cord-303322-d69o3z8d 220 21 33 33 CD cord-303322-d69o3z8d 220 22 ] ] -RRB- cord-303322-d69o3z8d 220 23 that that IN cord-303322-d69o3z8d 220 24 influences influence VBZ cord-303322-d69o3z8d 220 25 their -PRON- PRP$ cord-303322-d69o3z8d 220 26 discharge discharge NN cord-303322-d69o3z8d 220 27 . . . cord-303322-d69o3z8d 221 1 Thus thus RB cord-303322-d69o3z8d 221 2 we -PRON- PRP cord-303322-d69o3z8d 221 3 used use VBD cord-303322-d69o3z8d 221 4 LOS LOS NNP cord-303322-d69o3z8d 221 5 defined define VBN cord-303322-d69o3z8d 221 6 in in IN cord-303322-d69o3z8d 221 7 accordance accordance NN cord-303322-d69o3z8d 221 8 with with IN cord-303322-d69o3z8d 221 9 ' ' `` cord-303322-d69o3z8d 221 10 ready ready JJ cord-303322-d69o3z8d 221 11 for for IN cord-303322-d69o3z8d 221 12 respiratory respiratory JJ cord-303322-d69o3z8d 221 13 discharge discharge NN cord-303322-d69o3z8d 221 14 ' ' '' cord-303322-d69o3z8d 221 15 . . . cord-303322-d69o3z8d 222 1 Our -PRON- PRP$ cord-303322-d69o3z8d 222 2 study study NN cord-303322-d69o3z8d 222 3 only only RB cord-303322-d69o3z8d 222 4 addresses address VBZ cord-303322-d69o3z8d 222 5 infants infant NNS cord-303322-d69o3z8d 222 6 hospitalised hospitalise VBN cord-303322-d69o3z8d 222 7 for for IN cord-303322-d69o3z8d 222 8 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 222 9 . . . cord-303322-d69o3z8d 223 1 The the DT cord-303322-d69o3z8d 223 2 impact impact NN cord-303322-d69o3z8d 223 3 of of IN cord-303322-d69o3z8d 223 4 variable variable JJ cord-303322-d69o3z8d 223 5 presentation presentation NN cord-303322-d69o3z8d 223 6 particularly particularly RB cord-303322-d69o3z8d 223 7 that that RB cord-303322-d69o3z8d 223 8 related relate VBD cord-303322-d69o3z8d 223 9 to to IN cord-303322-d69o3z8d 223 10 the the DT cord-303322-d69o3z8d 223 11 potential potential JJ cord-303322-d69o3z8d 223 12 influence influence NN cord-303322-d69o3z8d 223 13 of of IN cord-303322-d69o3z8d 223 14 azithromycin azithromycin NN cord-303322-d69o3z8d 223 15 's 's POS cord-303322-d69o3z8d 223 16 acute acute JJ cord-303322-d69o3z8d 223 17 immune immune JJ cord-303322-d69o3z8d 223 18 modulation modulation NN cord-303322-d69o3z8d 223 19 effect effect NN cord-303322-d69o3z8d 223 20 is be VBZ cord-303322-d69o3z8d 223 21 a a DT cord-303322-d69o3z8d 223 22 limitation limitation NN cord-303322-d69o3z8d 223 23 of of IN cord-303322-d69o3z8d 223 24 our -PRON- PRP$ cord-303322-d69o3z8d 223 25 study study NN cord-303322-d69o3z8d 223 26 . . . cord-303322-d69o3z8d 224 1 However however RB cord-303322-d69o3z8d 224 2 our -PRON- PRP$ cord-303322-d69o3z8d 224 3 study study NN cord-303322-d69o3z8d 224 4 design design NN cord-303322-d69o3z8d 224 5 minimises minimise VBZ cord-303322-d69o3z8d 224 6 the the DT cord-303322-d69o3z8d 224 7 impact impact NN cord-303322-d69o3z8d 224 8 of of IN cord-303322-d69o3z8d 224 9 variable variable JJ cord-303322-d69o3z8d 224 10 presentation presentation NN cord-303322-d69o3z8d 224 11 by by IN cord-303322-d69o3z8d 224 12 : : : cord-303322-d69o3z8d 224 13 ( ( -LRB- cord-303322-d69o3z8d 224 14 a a LS cord-303322-d69o3z8d 224 15 ) ) -RRB- cord-303322-d69o3z8d 224 16 standardising standardise VBG cord-303322-d69o3z8d 224 17 our -PRON- PRP$ cord-303322-d69o3z8d 224 18 inclusion inclusion NN cord-303322-d69o3z8d 224 19 criteria criterion NNS cord-303322-d69o3z8d 224 20 , , , cord-303322-d69o3z8d 224 21 ( ( -LRB- cord-303322-d69o3z8d 224 22 b b NN cord-303322-d69o3z8d 224 23 ) ) -RRB- cord-303322-d69o3z8d 224 24 limiting limit VBG cord-303322-d69o3z8d 224 25 enrolment enrolment NN cord-303322-d69o3z8d 224 26 to to IN cord-303322-d69o3z8d 224 27 within within IN cord-303322-d69o3z8d 224 28 24 24 CD cord-303322-d69o3z8d 224 29 hours hour NNS cord-303322-d69o3z8d 224 30 of of IN cord-303322-d69o3z8d 224 31 hospitalisation hospitalisation NN cord-303322-d69o3z8d 224 32 ; ; , cord-303322-d69o3z8d 224 33 ( ( -LRB- cord-303322-d69o3z8d 224 34 c c NN cord-303322-d69o3z8d 224 35 ) ) -RRB- cord-303322-d69o3z8d 224 36 adopting adopt VBG cord-303322-d69o3z8d 224 37 a a DT cord-303322-d69o3z8d 224 38 strategy strategy NN cord-303322-d69o3z8d 224 39 ( ( -LRB- cord-303322-d69o3z8d 224 40 double double RB cord-303322-d69o3z8d 224 41 blind blind JJ cord-303322-d69o3z8d 224 42 , , , cord-303322-d69o3z8d 224 43 placebo placebo NN cord-303322-d69o3z8d 224 44 controlled control VBN cord-303322-d69o3z8d 224 45 , , , cord-303322-d69o3z8d 224 46 allocation allocation NN cord-303322-d69o3z8d 224 47 concealed conceal VBN cord-303322-d69o3z8d 224 48 methodology methodology NN cord-303322-d69o3z8d 224 49 ) ) -RRB- cord-303322-d69o3z8d 224 50 that that WDT cord-303322-d69o3z8d 224 51 would would MD cord-303322-d69o3z8d 224 52 theoretically theoretically RB cord-303322-d69o3z8d 224 53 distribute distribute VB cord-303322-d69o3z8d 224 54 any any DT cord-303322-d69o3z8d 224 55 effect effect NN cord-303322-d69o3z8d 224 56 equally equally RB cord-303322-d69o3z8d 224 57 between between IN cord-303322-d69o3z8d 224 58 groups group NNS cord-303322-d69o3z8d 224 59 . . . cord-303322-d69o3z8d 225 1 Additionally additionally RB cord-303322-d69o3z8d 225 2 in in IN cord-303322-d69o3z8d 225 3 the the DT cord-303322-d69o3z8d 225 4 event event NN cord-303322-d69o3z8d 225 5 that that IN cord-303322-d69o3z8d 225 6 differences difference NNS cord-303322-d69o3z8d 225 7 in in IN cord-303322-d69o3z8d 225 8 baseline baseline JJ cord-303322-d69o3z8d 225 9 data datum NNS cord-303322-d69o3z8d 225 10 between between IN cord-303322-d69o3z8d 225 11 groups group NNS cord-303322-d69o3z8d 225 12 are be VBP cord-303322-d69o3z8d 225 13 found find VBN cord-303322-d69o3z8d 225 14 , , , cord-303322-d69o3z8d 225 15 we -PRON- PRP cord-303322-d69o3z8d 225 16 will will MD cord-303322-d69o3z8d 225 17 use use VB cord-303322-d69o3z8d 225 18 statistical statistical JJ cord-303322-d69o3z8d 225 19 methods method NNS cord-303322-d69o3z8d 225 20 ( ( -LRB- cord-303322-d69o3z8d 225 21 multivariate multivariate JJ cord-303322-d69o3z8d 225 22 analysis analysis NN cord-303322-d69o3z8d 225 23 ) ) -RRB- cord-303322-d69o3z8d 225 24 to to TO cord-303322-d69o3z8d 225 25 adjust adjust VB cord-303322-d69o3z8d 225 26 as as IN cord-303322-d69o3z8d 225 27 required require VBN cord-303322-d69o3z8d 225 28 . . . cord-303322-d69o3z8d 226 1 In in IN cord-303322-d69o3z8d 226 2 summary summary NN cord-303322-d69o3z8d 226 3 , , , cord-303322-d69o3z8d 226 4 given give VBN cord-303322-d69o3z8d 226 5 the the DT cord-303322-d69o3z8d 226 6 very very RB cord-303322-d69o3z8d 226 7 high high JJ cord-303322-d69o3z8d 226 8 burden burden NN cord-303322-d69o3z8d 226 9 of of IN cord-303322-d69o3z8d 226 10 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 226 11 in in IN cord-303322-d69o3z8d 226 12 Indigenous indigenous JJ cord-303322-d69o3z8d 226 13 infants infant NNS cord-303322-d69o3z8d 226 14 ( ( -LRB- cord-303322-d69o3z8d 226 15 the the DT cord-303322-d69o3z8d 226 16 age age NN cord-303322-d69o3z8d 226 17 when when WRB cord-303322-d69o3z8d 226 18 lung lung NN cord-303322-d69o3z8d 226 19 growth growth NN cord-303322-d69o3z8d 226 20 is be VBZ cord-303322-d69o3z8d 226 21 most most RBS cord-303322-d69o3z8d 226 22 critical critical JJ cord-303322-d69o3z8d 226 23 post post NN cord-303322-d69o3z8d 226 24 - - NN cord-303322-d69o3z8d 226 25 natally natally RB cord-303322-d69o3z8d 226 26 ) ) -RRB- cord-303322-d69o3z8d 226 27 , , , cord-303322-d69o3z8d 226 28 and and CC cord-303322-d69o3z8d 226 29 the the DT cord-303322-d69o3z8d 226 30 association association NN cord-303322-d69o3z8d 226 31 between between IN cord-303322-d69o3z8d 226 32 ALRI ALRI NNP cord-303322-d69o3z8d 226 33 and and CC cord-303322-d69o3z8d 226 34 future future JJ cord-303322-d69o3z8d 226 35 lung lung NN cord-303322-d69o3z8d 226 36 dysfunction dysfunction NN cord-303322-d69o3z8d 226 37 , , , cord-303322-d69o3z8d 226 38 our -PRON- PRP$ cord-303322-d69o3z8d 226 39 RCT RCT NNP cord-303322-d69o3z8d 226 40 on on IN cord-303322-d69o3z8d 226 41 azithromycin azithromycin NN cord-303322-d69o3z8d 226 42 in in IN cord-303322-d69o3z8d 226 43 Indigenous indigenous JJ cord-303322-d69o3z8d 226 44 Australian australian JJ cord-303322-d69o3z8d 226 45 infants infant NNS cord-303322-d69o3z8d 226 46 hospitalised hospitalise VBN cord-303322-d69o3z8d 226 47 with with IN cord-303322-d69o3z8d 226 48 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 226 49 has have VBZ cord-303322-d69o3z8d 226 50 the the DT cord-303322-d69o3z8d 226 51 potential potential NN cord-303322-d69o3z8d 226 52 to to TO cord-303322-d69o3z8d 226 53 have have VB cord-303322-d69o3z8d 226 54 both both DT cord-303322-d69o3z8d 226 55 short short JJ cord-303322-d69o3z8d 226 56 term term NN cord-303322-d69o3z8d 226 57 gains gain NNS cord-303322-d69o3z8d 226 58 and and CC cord-303322-d69o3z8d 226 59 a a DT cord-303322-d69o3z8d 226 60 long long JJ cord-303322-d69o3z8d 226 61 - - HYPH cord-303322-d69o3z8d 226 62 term term NN cord-303322-d69o3z8d 226 63 benefit benefit NN cord-303322-d69o3z8d 226 64 for for IN cord-303322-d69o3z8d 226 65 reducing reduce VBG cord-303322-d69o3z8d 226 66 morbidity morbidity NN cord-303322-d69o3z8d 226 67 of of IN cord-303322-d69o3z8d 226 68 respiratory respiratory JJ cord-303322-d69o3z8d 226 69 illness illness NN cord-303322-d69o3z8d 226 70 . . . cord-303322-d69o3z8d 226 71 _SP cord-303322-d69o3z8d 227 1 Subcommittee Subcommittee NNP cord-303322-d69o3z8d 227 2 on on IN cord-303322-d69o3z8d 227 3 Diagnosis Diagnosis NNP cord-303322-d69o3z8d 227 4 and and CC cord-303322-d69o3z8d 227 5 Management Management NNP cord-303322-d69o3z8d 227 6 of of IN cord-303322-d69o3z8d 227 7 Bronchiolitis Bronchiolitis NNP cord-303322-d69o3z8d 227 8 : : : cord-303322-d69o3z8d 228 1 Diagnosis Diagnosis NNP cord-303322-d69o3z8d 228 2 and and CC cord-303322-d69o3z8d 228 3 Management Management NNP cord-303322-d69o3z8d 228 4 of of IN cord-303322-d69o3z8d 228 5 Bronchiolitis Bronchiolitis NNP cord-303322-d69o3z8d 228 6 Predicting predict VBG cord-303322-d69o3z8d 228 7 respiratory respiratory JJ cord-303322-d69o3z8d 228 8 syncytial syncytial JJ cord-303322-d69o3z8d 228 9 virus virus NN cord-303322-d69o3z8d 228 10 hospitalisation hospitalisation NN cord-303322-d69o3z8d 228 11 in in IN cord-303322-d69o3z8d 228 12 Australian australian JJ cord-303322-d69o3z8d 228 13 children child NNS cord-303322-d69o3z8d 228 14 Bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 228 15 : : : cord-303322-d69o3z8d 228 16 assessment assessment NN cord-303322-d69o3z8d 228 17 and and CC cord-303322-d69o3z8d 228 18 evidence evidence NN cord-303322-d69o3z8d 228 19 - - HYPH cord-303322-d69o3z8d 228 20 based base VBN cord-303322-d69o3z8d 228 21 management management NN cord-303322-d69o3z8d 228 22 From from IN cord-303322-d69o3z8d 228 23 infancy infancy NN cord-303322-d69o3z8d 228 24 to to IN cord-303322-d69o3z8d 228 25 young young JJ cord-303322-d69o3z8d 228 26 adulthood adulthood NN cord-303322-d69o3z8d 228 27 : : : cord-303322-d69o3z8d 228 28 health health NN cord-303322-d69o3z8d 228 29 status status NN cord-303322-d69o3z8d 228 30 in in IN cord-303322-d69o3z8d 228 31 the the DT cord-303322-d69o3z8d 228 32 Northern Northern NNP cord-303322-d69o3z8d 228 33 Territory Territory NNP cord-303322-d69o3z8d 228 34 2006 2006 CD cord-303322-d69o3z8d 228 35 . . . cord-303322-d69o3z8d 229 1 Department Department NNP cord-303322-d69o3z8d 229 2 of of IN cord-303322-d69o3z8d 229 3 Health Health NNP cord-303322-d69o3z8d 229 4 andCommunity andCommunity NNP cord-303322-d69o3z8d 230 1 Services Services NNPS cord-303322-d69o3z8d 230 2 Hospitalisation Hospitalisation NNP cord-303322-d69o3z8d 230 3 of of IN cord-303322-d69o3z8d 230 4 Indigenous indigenous JJ cord-303322-d69o3z8d 230 5 children child NNS cord-303322-d69o3z8d 230 6 in in IN cord-303322-d69o3z8d 230 7 the the DT cord-303322-d69o3z8d 230 8 Northern Northern NNP cord-303322-d69o3z8d 230 9 Territory Territory NNP cord-303322-d69o3z8d 230 10 for for IN cord-303322-d69o3z8d 230 11 lower low JJR cord-303322-d69o3z8d 230 12 respiratory respiratory JJ cord-303322-d69o3z8d 230 13 illness illness NN cord-303322-d69o3z8d 230 14 in in IN cord-303322-d69o3z8d 230 15 the the DT cord-303322-d69o3z8d 230 16 first first JJ cord-303322-d69o3z8d 230 17 year year NN cord-303322-d69o3z8d 230 18 of of IN cord-303322-d69o3z8d 230 19 life life NN cord-303322-d69o3z8d 230 20 Risks risk NNS cord-303322-d69o3z8d 230 21 of of IN cord-303322-d69o3z8d 230 22 severity severity NN cord-303322-d69o3z8d 230 23 and and CC cord-303322-d69o3z8d 230 24 readmission readmission NN cord-303322-d69o3z8d 230 25 of of IN cord-303322-d69o3z8d 230 26 Indigenous indigenous JJ cord-303322-d69o3z8d 230 27 and and CC cord-303322-d69o3z8d 230 28 non non JJ cord-303322-d69o3z8d 230 29 - - JJ cord-303322-d69o3z8d 230 30 Indigenous indigenous JJ cord-303322-d69o3z8d 230 31 children child NNS cord-303322-d69o3z8d 230 32 hospitalised hospitalise VBN cord-303322-d69o3z8d 230 33 for for IN cord-303322-d69o3z8d 230 34 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 230 35 A a DT cord-303322-d69o3z8d 230 36 hospital hospital NN cord-303322-d69o3z8d 230 37 - - HYPH cord-303322-d69o3z8d 230 38 based base VBN cord-303322-d69o3z8d 230 39 case case NN cord-303322-d69o3z8d 230 40 - - HYPH cord-303322-d69o3z8d 230 41 control control NN cord-303322-d69o3z8d 230 42 study study NN cord-303322-d69o3z8d 230 43 of of IN cord-303322-d69o3z8d 230 44 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 230 45 in in IN cord-303322-d69o3z8d 230 46 Indigenous indigenous JJ cord-303322-d69o3z8d 230 47 children child NNS cord-303322-d69o3z8d 230 48 in in IN cord-303322-d69o3z8d 230 49 Central Central NNP cord-303322-d69o3z8d 230 50 Australia Australia NNP cord-303322-d69o3z8d 230 51 Lifecourse Lifecourse NNP cord-303322-d69o3z8d 230 52 predictors predictor NNS cord-303322-d69o3z8d 230 53 of of IN cord-303322-d69o3z8d 230 54 adult adult NN cord-303322-d69o3z8d 230 55 respiratory respiratory JJ cord-303322-d69o3z8d 230 56 function function NN cord-303322-d69o3z8d 230 57 : : : cord-303322-d69o3z8d 230 58 results result NNS cord-303322-d69o3z8d 230 59 from from IN cord-303322-d69o3z8d 230 60 the the DT cord-303322-d69o3z8d 230 61 Newcastle Newcastle NNP cord-303322-d69o3z8d 230 62 Thousand Thousand NNP cord-303322-d69o3z8d 230 63 Families Families NNPS cord-303322-d69o3z8d 230 64 Study Study NNP cord-303322-d69o3z8d 230 65 Lung Lung NNP cord-303322-d69o3z8d 230 66 parenchyma parenchyma NN cord-303322-d69o3z8d 230 67 at at IN cord-303322-d69o3z8d 230 68 maturity maturity NN cord-303322-d69o3z8d 230 69 is be VBZ cord-303322-d69o3z8d 230 70 influenced influence VBN cord-303322-d69o3z8d 230 71 by by IN cord-303322-d69o3z8d 230 72 postnatal postnatal JJ cord-303322-d69o3z8d 230 73 growth growth NN cord-303322-d69o3z8d 230 74 but but CC cord-303322-d69o3z8d 230 75 not not RB cord-303322-d69o3z8d 230 76 by by IN cord-303322-d69o3z8d 230 77 moderate moderate JJ cord-303322-d69o3z8d 230 78 preterm preterm JJ cord-303322-d69o3z8d 230 79 birth birth NN cord-303322-d69o3z8d 230 80 in in IN cord-303322-d69o3z8d 230 81 sheep sheep NN cord-303322-d69o3z8d 230 82 Postnatal postnatal JJ cord-303322-d69o3z8d 230 83 growth growth NN cord-303322-d69o3z8d 230 84 rate rate NN cord-303322-d69o3z8d 230 85 , , , cord-303322-d69o3z8d 230 86 but but CC cord-303322-d69o3z8d 230 87 not not RB cord-303322-d69o3z8d 230 88 mild mild JJ cord-303322-d69o3z8d 230 89 preterm preterm JJ cord-303322-d69o3z8d 230 90 birth birth NN cord-303322-d69o3z8d 230 91 , , , cord-303322-d69o3z8d 230 92 influences influence VBZ cord-303322-d69o3z8d 230 93 airway airway NN cord-303322-d69o3z8d 230 94 structure structure NN cord-303322-d69o3z8d 230 95 in in IN cord-303322-d69o3z8d 230 96 adult adult NN cord-303322-d69o3z8d 230 97 sheep sheep NNS cord-303322-d69o3z8d 230 98 challenged challenge VBN cord-303322-d69o3z8d 230 99 with with IN cord-303322-d69o3z8d 230 100 house house NN cord-303322-d69o3z8d 230 101 dust dust NN cord-303322-d69o3z8d 230 102 mite mite NNP cord-303322-d69o3z8d 230 103 The the DT cord-303322-d69o3z8d 230 104 mammalian mammalian JJ cord-303322-d69o3z8d 230 105 respiratory respiratory JJ cord-303322-d69o3z8d 230 106 system system NN cord-303322-d69o3z8d 230 107 and and CC cord-303322-d69o3z8d 230 108 critical critical JJ cord-303322-d69o3z8d 230 109 windows window NNS cord-303322-d69o3z8d 230 110 of of IN cord-303322-d69o3z8d 230 111 exposure exposure NN cord-303322-d69o3z8d 230 112 for for IN cord-303322-d69o3z8d 230 113 children child NNS cord-303322-d69o3z8d 230 114 's 's POS cord-303322-d69o3z8d 230 115 health health NN cord-303322-d69o3z8d 230 116 . . . cord-303322-d69o3z8d 231 1 Environ Environ NNP cord-303322-d69o3z8d 231 2 Health Health NNP cord-303322-d69o3z8d 231 3 Perspect Perspect NNP cord-303322-d69o3z8d 231 4 Australian Australian NNP cord-303322-d69o3z8d 231 5 Health Health NNP cord-303322-d69o3z8d 231 6 Ministers Ministers NNPS cord-303322-d69o3z8d 231 7 ' ' POS cord-303322-d69o3z8d 231 8 Advisory Advisory NNP cord-303322-d69o3z8d 231 9 Council Council NNP cord-303322-d69o3z8d 231 10 2 2 CD cord-303322-d69o3z8d 231 11 : : : cord-303322-d69o3z8d 232 1 Aboriginal Aboriginal NNP cord-303322-d69o3z8d 232 2 and and CC cord-303322-d69o3z8d 232 3 Torres Torres NNP cord-303322-d69o3z8d 232 4 Strait Strait NNP cord-303322-d69o3z8d 232 5 Islander Islander NNP cord-303322-d69o3z8d 232 6 Health Health NNP cord-303322-d69o3z8d 232 7 Performance Performance NNP cord-303322-d69o3z8d 232 8 Framework Framework NNP cord-303322-d69o3z8d 232 9 Report Report NNP cord-303322-d69o3z8d 232 10 . . . cord-303322-d69o3z8d 233 1 AHMAC AHMAC NNP cord-303322-d69o3z8d 233 2 , , , cord-303322-d69o3z8d 233 3 Canberra Canberra NNP cord-303322-d69o3z8d 233 4 Non Non NNP cord-303322-d69o3z8d 233 5 - - NNP cord-303322-d69o3z8d 233 6 CF cf NN cord-303322-d69o3z8d 233 7 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 233 8 - - HYPH cord-303322-d69o3z8d 233 9 clinical clinical JJ cord-303322-d69o3z8d 233 10 and and CC cord-303322-d69o3z8d 233 11 HRCT hrct JJ cord-303322-d69o3z8d 233 12 evaluation evaluation NN cord-303322-d69o3z8d 234 1 Bronchiectasis Bronchiectasis NNP cord-303322-d69o3z8d 234 2 : : : cord-303322-d69o3z8d 234 3 so so RB cord-303322-d69o3z8d 234 4 much much RB cord-303322-d69o3z8d 234 5 yet yet RB cord-303322-d69o3z8d 234 6 to to TO cord-303322-d69o3z8d 234 7 learn learn VB cord-303322-d69o3z8d 234 8 and and CC cord-303322-d69o3z8d 234 9 to to TO cord-303322-d69o3z8d 234 10 do do VB cord-303322-d69o3z8d 234 11 Frequent frequent JJ cord-303322-d69o3z8d 234 12 detection detection NN cord-303322-d69o3z8d 234 13 of of IN cord-303322-d69o3z8d 234 14 human human JJ cord-303322-d69o3z8d 234 15 rhinoviruses rhinovirus NNS cord-303322-d69o3z8d 234 16 , , , cord-303322-d69o3z8d 234 17 paramyxoviruses paramyxovirus NNS cord-303322-d69o3z8d 234 18 , , , cord-303322-d69o3z8d 234 19 coronaviruses coronaviruse NNS cord-303322-d69o3z8d 234 20 , , , cord-303322-d69o3z8d 234 21 and and CC cord-303322-d69o3z8d 234 22 bocavirus bocavirus NN cord-303322-d69o3z8d 234 23 during during IN cord-303322-d69o3z8d 234 24 acute acute JJ cord-303322-d69o3z8d 234 25 respiratory respiratory JJ cord-303322-d69o3z8d 234 26 tract tract NN cord-303322-d69o3z8d 234 27 infections infection NNS cord-303322-d69o3z8d 235 1 Prenatal prenatal JJ cord-303322-d69o3z8d 235 2 inflammation inflammation NN cord-303322-d69o3z8d 235 3 and and CC cord-303322-d69o3z8d 235 4 lung lung NN cord-303322-d69o3z8d 235 5 development development NN cord-303322-d69o3z8d 235 6 Contribution Contribution NNP cord-303322-d69o3z8d 235 7 of of IN cord-303322-d69o3z8d 235 8 inflammation inflammation NN cord-303322-d69o3z8d 235 9 to to IN cord-303322-d69o3z8d 235 10 lung lung NN cord-303322-d69o3z8d 235 11 injury injury NN cord-303322-d69o3z8d 235 12 and and CC cord-303322-d69o3z8d 235 13 development development NN cord-303322-d69o3z8d 236 1 Intermittent intermittent JJ cord-303322-d69o3z8d 236 2 azithromycin azithromycin NN cord-303322-d69o3z8d 236 3 treatment treatment NN cord-303322-d69o3z8d 236 4 for for IN cord-303322-d69o3z8d 236 5 respiratory respiratory JJ cord-303322-d69o3z8d 236 6 symptoms symptom NNS cord-303322-d69o3z8d 236 7 in in IN cord-303322-d69o3z8d 236 8 patients patient NNS cord-303322-d69o3z8d 236 9 with with IN cord-303322-d69o3z8d 236 10 chronic chronic JJ cord-303322-d69o3z8d 236 11 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 236 12 pneumoniae pneumoniae NN cord-303322-d69o3z8d 236 13 infection infection NN cord-303322-d69o3z8d 236 14 Rate rate NN cord-303322-d69o3z8d 236 15 of of IN cord-303322-d69o3z8d 236 16 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 236 17 trachomatis trachomatis NN cord-303322-d69o3z8d 236 18 and and CC cord-303322-d69o3z8d 236 19 Chlamydia Chlamydia NNP cord-303322-d69o3z8d 236 20 pneumoniae pneumoniae NN cord-303322-d69o3z8d 236 21 in in IN cord-303322-d69o3z8d 236 22 paediatric paediatric JJ cord-303322-d69o3z8d 236 23 respiratory respiratory JJ cord-303322-d69o3z8d 236 24 infections infection NNS cord-303322-d69o3z8d 237 1 High high JJ cord-303322-d69o3z8d 237 2 rate rate NN cord-303322-d69o3z8d 237 3 of of IN cord-303322-d69o3z8d 237 4 Simkania Simkania NNP cord-303322-d69o3z8d 237 5 negevensis negevensis NN cord-303322-d69o3z8d 237 6 among among IN cord-303322-d69o3z8d 237 7 Canadian canadian JJ cord-303322-d69o3z8d 237 8 inuit inuit JJ cord-303322-d69o3z8d 237 9 infants infant NNS cord-303322-d69o3z8d 237 10 hospitalized hospitalize VBN cord-303322-d69o3z8d 237 11 with with IN cord-303322-d69o3z8d 237 12 lower low JJR cord-303322-d69o3z8d 237 13 respiratory respiratory JJ cord-303322-d69o3z8d 237 14 tract tract NN cord-303322-d69o3z8d 237 15 infections infection NNS cord-303322-d69o3z8d 237 16 Bacteraemia Bacteraemia NNP cord-303322-d69o3z8d 237 17 and and CC cord-303322-d69o3z8d 237 18 antibiotic antibiotic JJ cord-303322-d69o3z8d 237 19 use use NN cord-303322-d69o3z8d 237 20 in in IN cord-303322-d69o3z8d 237 21 respiratory respiratory JJ cord-303322-d69o3z8d 237 22 syncytial syncytial JJ cord-303322-d69o3z8d 237 23 virus virus NN cord-303322-d69o3z8d 237 24 infections infection NNS cord-303322-d69o3z8d 237 25 Antibiotics antibiotic NNS cord-303322-d69o3z8d 237 26 for for IN cord-303322-d69o3z8d 237 27 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 237 28 in in IN cord-303322-d69o3z8d 237 29 children child NNS cord-303322-d69o3z8d 237 30 . . . cord-303322-d69o3z8d 238 1 Cochrane Cochrane NNP cord-303322-d69o3z8d 238 2 Database Database NNP cord-303322-d69o3z8d 238 3 Syst Syst NNP cord-303322-d69o3z8d 238 4 Rev Rev NNP cord-303322-d69o3z8d 238 5 Streptococcus Streptococcus NNP cord-303322-d69o3z8d 238 6 pneumoniae pneumoniae NN cord-303322-d69o3z8d 238 7 colonisation colonisation NN cord-303322-d69o3z8d 238 8 : : : cord-303322-d69o3z8d 239 1 the the DT cord-303322-d69o3z8d 239 2 key key NN cord-303322-d69o3z8d 239 3 to to IN cord-303322-d69o3z8d 239 4 pneumococcal pneumococcal JJ cord-303322-d69o3z8d 239 5 disease disease NN cord-303322-d69o3z8d 239 6 Bacterial bacterial JJ cord-303322-d69o3z8d 239 7 colonization colonization NN cord-303322-d69o3z8d 239 8 of of IN cord-303322-d69o3z8d 239 9 the the DT cord-303322-d69o3z8d 239 10 nasopharynx nasopharynx NN cord-303322-d69o3z8d 239 11 predicts predict VBZ cord-303322-d69o3z8d 239 12 very very RB cord-303322-d69o3z8d 239 13 early early JJ cord-303322-d69o3z8d 239 14 onset onset NN cord-303322-d69o3z8d 239 15 and and CC cord-303322-d69o3z8d 239 16 persistence persistence NN cord-303322-d69o3z8d 239 17 of of IN cord-303322-d69o3z8d 239 18 otitis otitis NN cord-303322-d69o3z8d 239 19 media medium NNS cord-303322-d69o3z8d 239 20 in in IN cord-303322-d69o3z8d 239 21 Australian australian JJ cord-303322-d69o3z8d 239 22 aboriginal aboriginal JJ cord-303322-d69o3z8d 239 23 infants infant NNS cord-303322-d69o3z8d 239 24 Mechanisms Mechanisms NNPS cord-303322-d69o3z8d 239 25 of of IN cord-303322-d69o3z8d 239 26 action action NN cord-303322-d69o3z8d 239 27 and and CC cord-303322-d69o3z8d 239 28 clinical clinical JJ cord-303322-d69o3z8d 239 29 application application NN cord-303322-d69o3z8d 239 30 of of IN cord-303322-d69o3z8d 239 31 macrolides macrolide NNS cord-303322-d69o3z8d 239 32 as as IN cord-303322-d69o3z8d 239 33 immunomodulatory immunomodulatory JJ cord-303322-d69o3z8d 239 34 medications medication NNS cord-303322-d69o3z8d 239 35 Clarithromycin Clarithromycin NNP cord-303322-d69o3z8d 239 36 in in IN cord-303322-d69o3z8d 239 37 the the DT cord-303322-d69o3z8d 239 38 treatment treatment NN cord-303322-d69o3z8d 239 39 of of IN cord-303322-d69o3z8d 239 40 RSV RSV NNP cord-303322-d69o3z8d 239 41 bronchiolitis bronchiolitis NNP cord-303322-d69o3z8d 239 42 : : : cord-303322-d69o3z8d 239 43 a a DT cord-303322-d69o3z8d 239 44 double double JJ cord-303322-d69o3z8d 239 45 - - HYPH cord-303322-d69o3z8d 239 46 blind blind JJ cord-303322-d69o3z8d 239 47 , , , cord-303322-d69o3z8d 239 48 randomised randomised JJ cord-303322-d69o3z8d 239 49 , , , cord-303322-d69o3z8d 239 50 placebo placebo NN cord-303322-d69o3z8d 239 51 - - HYPH cord-303322-d69o3z8d 239 52 controlled control VBN cord-303322-d69o3z8d 239 53 trial trial NN cord-303322-d69o3z8d 239 54 Azithromycin Azithromycin NNP cord-303322-d69o3z8d 239 55 does do VBZ cord-303322-d69o3z8d 239 56 not not RB cord-303322-d69o3z8d 239 57 improve improve VB cord-303322-d69o3z8d 239 58 disease disease NN cord-303322-d69o3z8d 239 59 course course NN cord-303322-d69o3z8d 239 60 in in IN cord-303322-d69o3z8d 239 61 hospitalized hospitalize VBN cord-303322-d69o3z8d 239 62 infants infant NNS cord-303322-d69o3z8d 239 63 with with IN cord-303322-d69o3z8d 239 64 respiratory respiratory JJ cord-303322-d69o3z8d 239 65 syncytial syncytial JJ cord-303322-d69o3z8d 239 66 virus virus NN cord-303322-d69o3z8d 239 67 ( ( -LRB- cord-303322-d69o3z8d 239 68 RSV RSV NNP cord-303322-d69o3z8d 239 69 ) ) -RRB- cord-303322-d69o3z8d 239 70 lower low JJR cord-303322-d69o3z8d 239 71 respiratory respiratory JJ cord-303322-d69o3z8d 239 72 tract tract NN cord-303322-d69o3z8d 239 73 disease disease NN cord-303322-d69o3z8d 239 74 : : : cord-303322-d69o3z8d 239 75 A a DT cord-303322-d69o3z8d 239 76 randomized randomized JJ cord-303322-d69o3z8d 239 77 equivalence equivalence NN cord-303322-d69o3z8d 239 78 trial trial NN cord-303322-d69o3z8d 239 79 Non non JJ cord-303322-d69o3z8d 239 80 - - JJ cord-303322-d69o3z8d 239 81 cystic cystic JJ cord-303322-d69o3z8d 239 82 - - HYPH cord-303322-d69o3z8d 239 83 fibrosis fibrosis NN cord-303322-d69o3z8d 239 84 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 239 85 in in IN cord-303322-d69o3z8d 239 86 children child NNS cord-303322-d69o3z8d 239 87 : : : cord-303322-d69o3z8d 239 88 a a DT cord-303322-d69o3z8d 239 89 persisting persist VBG cord-303322-d69o3z8d 239 90 problem problem NN cord-303322-d69o3z8d 239 91 in in IN cord-303322-d69o3z8d 239 92 developing develop VBG cord-303322-d69o3z8d 239 93 countries country NNS cord-303322-d69o3z8d 239 94 Diagnosis diagnosis NN cord-303322-d69o3z8d 239 95 and and CC cord-303322-d69o3z8d 239 96 testing testing NN cord-303322-d69o3z8d 239 97 in in IN cord-303322-d69o3z8d 239 98 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 239 99 : : : cord-303322-d69o3z8d 239 100 a a DT cord-303322-d69o3z8d 239 101 systematic systematic JJ cord-303322-d69o3z8d 239 102 review review NN cord-303322-d69o3z8d 239 103 Acute acute JJ cord-303322-d69o3z8d 239 104 viral viral JJ cord-303322-d69o3z8d 239 105 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 239 106 : : : cord-303322-d69o3z8d 239 107 to to TO cord-303322-d69o3z8d 239 108 treat treat VB cord-303322-d69o3z8d 239 109 or or CC cord-303322-d69o3z8d 239 110 not not RB cord-303322-d69o3z8d 239 111 to to TO cord-303322-d69o3z8d 239 112 treat treat VB cord-303322-d69o3z8d 240 1 -that -that WP cord-303322-d69o3z8d 240 2 is be VBZ cord-303322-d69o3z8d 240 3 the the DT cord-303322-d69o3z8d 240 4 question question NN cord-303322-d69o3z8d 240 5 The the DT cord-303322-d69o3z8d 240 6 management management NN cord-303322-d69o3z8d 240 7 of of IN cord-303322-d69o3z8d 240 8 acute acute JJ cord-303322-d69o3z8d 240 9 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 240 10 . . . cord-303322-d69o3z8d 241 1 Thoracic Thoracic NNP cord-303322-d69o3z8d 241 2 Society Society NNP cord-303322-d69o3z8d 241 3 of of IN cord-303322-d69o3z8d 241 4 Australia Australia NNP cord-303322-d69o3z8d 241 5 and and CC cord-303322-d69o3z8d 241 6 New New NNP cord-303322-d69o3z8d 241 7 Zealand Zealand NNP cord-303322-d69o3z8d 241 8 Respiratory respiratory JJ cord-303322-d69o3z8d 241 9 syncytial syncytial JJ cord-303322-d69o3z8d 241 10 virus virus NN cord-303322-d69o3z8d 241 11 infection infection NN cord-303322-d69o3z8d 241 12 and and CC cord-303322-d69o3z8d 241 13 immunoprophylaxis immunoprophylaxis NN cord-303322-d69o3z8d 241 14 for for IN cord-303322-d69o3z8d 241 15 selected select VBN cord-303322-d69o3z8d 241 16 high high JJ cord-303322-d69o3z8d 241 17 - - HYPH cord-303322-d69o3z8d 241 18 risk risk NN cord-303322-d69o3z8d 241 19 children child NNS cord-303322-d69o3z8d 241 20 in in IN cord-303322-d69o3z8d 241 21 Central Central NNP cord-303322-d69o3z8d 241 22 Australia Australia NNP cord-303322-d69o3z8d 241 23 Zinc Zinc NNP cord-303322-d69o3z8d 241 24 and and CC cord-303322-d69o3z8d 241 25 Vitamin vitamin NN cord-303322-d69o3z8d 241 26 - - HYPH cord-303322-d69o3z8d 241 27 A a DT cord-303322-d69o3z8d 241 28 supplementation supplementation NN cord-303322-d69o3z8d 241 29 in in IN cord-303322-d69o3z8d 241 30 Indigenous indigenous JJ cord-303322-d69o3z8d 241 31 children child NNS cord-303322-d69o3z8d 241 32 hospitalised hospitalise VBN cord-303322-d69o3z8d 241 33 with with IN cord-303322-d69o3z8d 241 34 episodes episode NNS cord-303322-d69o3z8d 241 35 of of IN cord-303322-d69o3z8d 241 36 lower low JJR cord-303322-d69o3z8d 241 37 respiratory respiratory JJ cord-303322-d69o3z8d 241 38 tract tract NN cord-303322-d69o3z8d 241 39 infection infection NN cord-303322-d69o3z8d 241 40 : : : cord-303322-d69o3z8d 241 41 a a DT cord-303322-d69o3z8d 241 42 randomised randomised JJ cord-303322-d69o3z8d 241 43 controlled control VBN cord-303322-d69o3z8d 241 44 trial trial NN cord-303322-d69o3z8d 242 1 How how WRB cord-303322-d69o3z8d 242 2 should should MD cord-303322-d69o3z8d 242 3 we -PRON- PRP cord-303322-d69o3z8d 242 4 study study VB cord-303322-d69o3z8d 242 5 responses response NNS cord-303322-d69o3z8d 242 6 to to IN cord-303322-d69o3z8d 242 7 treatment treatment NN cord-303322-d69o3z8d 242 8 in in IN cord-303322-d69o3z8d 242 9 children child NNS cord-303322-d69o3z8d 242 10 with with IN cord-303322-d69o3z8d 242 11 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 242 12 ? ? . cord-303322-d69o3z8d 243 1 Respiratory respiratory JJ cord-303322-d69o3z8d 243 2 bacterial bacterial JJ cord-303322-d69o3z8d 243 3 pathogens pathogen NNS cord-303322-d69o3z8d 243 4 in in IN cord-303322-d69o3z8d 243 5 the the DT cord-303322-d69o3z8d 243 6 nasopharynx nasopharynx NN cord-303322-d69o3z8d 243 7 and and CC cord-303322-d69o3z8d 243 8 lower low JJR cord-303322-d69o3z8d 243 9 airways airway NNS cord-303322-d69o3z8d 243 10 of of IN cord-303322-d69o3z8d 243 11 Australian australian JJ cord-303322-d69o3z8d 243 12 Indigenous indigenous JJ cord-303322-d69o3z8d 243 13 children child NNS cord-303322-d69o3z8d 243 14 with with IN cord-303322-d69o3z8d 243 15 bronchiectasis bronchiectasis NN cord-303322-d69o3z8d 243 16 Streptococcus Streptococcus NNP cord-303322-d69o3z8d 243 17 pneumoniae pneumoniae NN cord-303322-d69o3z8d 243 18 and and CC cord-303322-d69o3z8d 243 19 noncapsular noncapsular JJ cord-303322-d69o3z8d 243 20 Haemophilus Haemophilus NNP cord-303322-d69o3z8d 243 21 influenzae influenzae NN cord-303322-d69o3z8d 243 22 nasal nasal NN cord-303322-d69o3z8d 243 23 carriage carriage NN cord-303322-d69o3z8d 243 24 and and CC cord-303322-d69o3z8d 243 25 hand hand NN cord-303322-d69o3z8d 243 26 contamination contamination NN cord-303322-d69o3z8d 243 27 in in IN cord-303322-d69o3z8d 243 28 children child NNS cord-303322-d69o3z8d 243 29 : : : cord-303322-d69o3z8d 243 30 a a DT cord-303322-d69o3z8d 243 31 comparison comparison NN cord-303322-d69o3z8d 243 32 of of IN cord-303322-d69o3z8d 243 33 two two CD cord-303322-d69o3z8d 243 34 populations population NNS cord-303322-d69o3z8d 243 35 at at IN cord-303322-d69o3z8d 243 36 risk risk NN cord-303322-d69o3z8d 243 37 of of IN cord-303322-d69o3z8d 243 38 otitis otitis NN cord-303322-d69o3z8d 243 39 media medium NNS cord-303322-d69o3z8d 243 40 Random Random NNP cord-303322-d69o3z8d 243 41 colony colony NN cord-303322-d69o3z8d 243 42 selection selection NN cord-303322-d69o3z8d 243 43 versus versus IN cord-303322-d69o3z8d 243 44 colony colony NN cord-303322-d69o3z8d 243 45 morphology morphology NN cord-303322-d69o3z8d 243 46 for for IN cord-303322-d69o3z8d 243 47 detection detection NN cord-303322-d69o3z8d 243 48 of of IN cord-303322-d69o3z8d 243 49 multiple multiple JJ cord-303322-d69o3z8d 243 50 pneumococcal pneumococcal JJ cord-303322-d69o3z8d 243 51 serotypes serotype NNS cord-303322-d69o3z8d 243 52 in in IN cord-303322-d69o3z8d 243 53 nasopharyngeal nasopharyngeal JJ cord-303322-d69o3z8d 243 54 swabs swab NNS cord-303322-d69o3z8d 244 1 The the DT cord-303322-d69o3z8d 244 2 impact impact NN cord-303322-d69o3z8d 244 3 of of IN cord-303322-d69o3z8d 244 4 viral viral JJ cord-303322-d69o3z8d 244 5 respiratory respiratory JJ cord-303322-d69o3z8d 244 6 infection infection NN cord-303322-d69o3z8d 244 7 on on IN cord-303322-d69o3z8d 244 8 the the DT cord-303322-d69o3z8d 244 9 severity severity NN cord-303322-d69o3z8d 244 10 and and CC cord-303322-d69o3z8d 244 11 recovery recovery NN cord-303322-d69o3z8d 244 12 from from IN cord-303322-d69o3z8d 244 13 an an DT cord-303322-d69o3z8d 244 14 asthma asthma NN cord-303322-d69o3z8d 244 15 exacerbation exacerbation NN cord-303322-d69o3z8d 244 16 Newly newly RB cord-303322-d69o3z8d 244 17 identified identify VBD cord-303322-d69o3z8d 244 18 respiratory respiratory JJ cord-303322-d69o3z8d 244 19 viruses virus NNS cord-303322-d69o3z8d 244 20 in in IN cord-303322-d69o3z8d 244 21 children child NNS cord-303322-d69o3z8d 244 22 with with IN cord-303322-d69o3z8d 244 23 asthma asthma NN cord-303322-d69o3z8d 244 24 exacerbation exacerbation NN cord-303322-d69o3z8d 244 25 not not RB cord-303322-d69o3z8d 244 26 requiring require VBG cord-303322-d69o3z8d 244 27 admission admission NN cord-303322-d69o3z8d 244 28 into into IN cord-303322-d69o3z8d 244 29 hospital hospital NN cord-303322-d69o3z8d 244 30 CONSORT CONSORT NNP cord-303322-d69o3z8d 244 31 2010 2010 CD cord-303322-d69o3z8d 244 32 Statement statement NN cord-303322-d69o3z8d 244 33 : : : cord-303322-d69o3z8d 244 34 updated update VBN cord-303322-d69o3z8d 244 35 guidelines guideline NNS cord-303322-d69o3z8d 244 36 for for IN cord-303322-d69o3z8d 244 37 reporting report VBG cord-303322-d69o3z8d 244 38 parallel parallel JJ cord-303322-d69o3z8d 244 39 group group NN cord-303322-d69o3z8d 244 40 randomised randomised JJ cord-303322-d69o3z8d 244 41 trials trial NNS cord-303322-d69o3z8d 244 42 Respiratory respiratory JJ cord-303322-d69o3z8d 244 43 morbidity morbidity NN cord-303322-d69o3z8d 244 44 in in IN cord-303322-d69o3z8d 244 45 central central JJ cord-303322-d69o3z8d 244 46 Australian australian JJ cord-303322-d69o3z8d 244 47 Aboriginal aboriginal JJ cord-303322-d69o3z8d 244 48 children child NNS cord-303322-d69o3z8d 244 49 with with IN cord-303322-d69o3z8d 244 50 alveolar alveolar JJ cord-303322-d69o3z8d 244 51 lobar lobar NN cord-303322-d69o3z8d 244 52 abnormalities abnormality NNS cord-303322-d69o3z8d 245 1 Once once RB cord-303322-d69o3z8d 245 2 - - HYPH cord-303322-d69o3z8d 245 3 weekly weekly JJ cord-303322-d69o3z8d 245 4 azithromycin azithromycin NN cord-303322-d69o3z8d 245 5 in in IN cord-303322-d69o3z8d 245 6 cystic cystic JJ cord-303322-d69o3z8d 245 7 fibrosis fibrosis NN cord-303322-d69o3z8d 245 8 with with IN cord-303322-d69o3z8d 245 9 chronic chronic JJ cord-303322-d69o3z8d 245 10 Pseudomonas Pseudomonas NNP cord-303322-d69o3z8d 245 11 aeruginosa aeruginosa NN cord-303322-d69o3z8d 245 12 infection infection NN cord-303322-d69o3z8d 246 1 Azithromycin Azithromycin NNP cord-303322-d69o3z8d 246 2 induces induce VBZ cord-303322-d69o3z8d 246 3 anti anti JJ cord-303322-d69o3z8d 246 4 - - JJ cord-303322-d69o3z8d 246 5 viral viral JJ cord-303322-d69o3z8d 246 6 responses response NNS cord-303322-d69o3z8d 246 7 in in IN cord-303322-d69o3z8d 246 8 bronchial bronchial JJ cord-303322-d69o3z8d 246 9 epithelial epithelial JJ cord-303322-d69o3z8d 246 10 cells cell NNS cord-303322-d69o3z8d 246 11 Evidence evidence NN cord-303322-d69o3z8d 246 12 of of IN cord-303322-d69o3z8d 246 13 human human JJ cord-303322-d69o3z8d 246 14 coronavirus coronavirus NN cord-303322-d69o3z8d 246 15 HKU1 HKU1 NNP cord-303322-d69o3z8d 246 16 and and CC cord-303322-d69o3z8d 246 17 human human JJ cord-303322-d69o3z8d 246 18 bocavirus bocavirus NN cord-303322-d69o3z8d 246 19 in in IN cord-303322-d69o3z8d 246 20 Australian australian JJ cord-303322-d69o3z8d 246 21 children child NNS cord-303322-d69o3z8d 247 1 Randomized randomized JJ cord-303322-d69o3z8d 247 2 placebo placebo NN cord-303322-d69o3z8d 247 3 - - HYPH cord-303322-d69o3z8d 247 4 controlled control VBN cord-303322-d69o3z8d 247 5 trial trial NN cord-303322-d69o3z8d 247 6 on on IN cord-303322-d69o3z8d 247 7 azithromycin azithromycin NNP cord-303322-d69o3z8d 247 8 to to TO cord-303322-d69o3z8d 247 9 reduce reduce VB cord-303322-d69o3z8d 247 10 the the DT cord-303322-d69o3z8d 247 11 morbidity morbidity NN cord-303322-d69o3z8d 247 12 of of IN cord-303322-d69o3z8d 247 13 bronchiolitis bronchiolitis NN cord-303322-d69o3z8d 247 14 in in IN cord-303322-d69o3z8d 247 15 Indigenous indigenous JJ cord-303322-d69o3z8d 247 16 Australian australian JJ cord-303322-d69o3z8d 247 17 infants infant NNS cord-303322-d69o3z8d 247 18 : : : cord-303322-d69o3z8d 247 19 rationale rationale NN cord-303322-d69o3z8d 247 20 and and CC cord-303322-d69o3z8d 247 21 protocol protocol NN cord-303322-d69o3z8d 248 1 We -PRON- PRP cord-303322-d69o3z8d 248 2 thank thank VBP cord-303322-d69o3z8d 248 3 the the DT cord-303322-d69o3z8d 248 4 research research NN cord-303322-d69o3z8d 248 5 staff staff NN cord-303322-d69o3z8d 248 6 ( ( -LRB- cord-303322-d69o3z8d 248 7 Lesley Lesley NNP cord-303322-d69o3z8d 248 8 Versteegh Versteegh NNP cord-303322-d69o3z8d 248 9 , , , cord-303322-d69o3z8d 248 10 Clare Clare NNP cord-303322-d69o3z8d 248 11 Wilson Wilson NNP cord-303322-d69o3z8d 248 12 , , , cord-303322-d69o3z8d 248 13 Nerida Nerida NNP cord-303322-d69o3z8d 248 14 Jacobsen Jacobsen NNP cord-303322-d69o3z8d 248 15 , , , cord-303322-d69o3z8d 248 16 Susan Susan NNP cord-303322-d69o3z8d 248 17 Pizzutto Pizzutto NNP cord-303322-d69o3z8d 248 18 and and CC cord-303322-d69o3z8d 248 19 Amber Amber NNP cord-303322-d69o3z8d 248 20 Revell Revell NNP cord-303322-d69o3z8d 248 21 ) ) -RRB- cord-303322-d69o3z8d 248 22 for for IN cord-303322-d69o3z8d 248 23 facilitating facilitate VBG cord-303322-d69o3z8d 248 24 the the DT cord-303322-d69o3z8d 248 25 study study NN cord-303322-d69o3z8d 248 26 , , , cord-303322-d69o3z8d 248 27 Joseph Joseph NNP cord-303322-d69o3z8d 248 28 McDonnell McDonnell NNP cord-303322-d69o3z8d 248 29 for for IN cord-303322-d69o3z8d 248 30 generating generate VBG cord-303322-d69o3z8d 248 31 the the DT cord-303322-d69o3z8d 248 32 randomisation randomisation NN cord-303322-d69o3z8d 248 33 sequences sequence NNS cord-303322-d69o3z8d 248 34 and and CC cord-303322-d69o3z8d 248 35 Jana Jana NNP cord-303322-d69o3z8d 248 36 Lai Lai NNP cord-303322-d69o3z8d 248 37 for for IN cord-303322-d69o3z8d 248 38 assistance assistance NN cord-303322-d69o3z8d 248 39 with with IN cord-303322-d69o3z8d 248 40 labelling label VBG cord-303322-d69o3z8d 248 41 the the DT cord-303322-d69o3z8d 248 42 bottles bottle NNS cord-303322-d69o3z8d 248 43 . . . cord-303322-d69o3z8d 249 1 We -PRON- PRP cord-303322-d69o3z8d 249 2 are be VBP cord-303322-d69o3z8d 249 3 also also RB cord-303322-d69o3z8d 249 4 grateful grateful JJ cord-303322-d69o3z8d 249 5 to to IN cord-303322-d69o3z8d 249 6 members member NNS cord-303322-d69o3z8d 249 7 of of IN cord-303322-d69o3z8d 249 8 the the DT cord-303322-d69o3z8d 249 9 Indigenous Indigenous NNP cord-303322-d69o3z8d 249 10 Reference Reference NNP cord-303322-d69o3z8d 249 11 Group Group NNP cord-303322-d69o3z8d 249 12 of of IN cord-303322-d69o3z8d 249 13 the the DT cord-303322-d69o3z8d 249 14 Child Child NNP cord-303322-d69o3z8d 249 15 Health Health NNP cord-303322-d69o3z8d 249 16 Division Division NNP cord-303322-d69o3z8d 249 17 at at IN cord-303322-d69o3z8d 249 18 Menzies Menzies NNP cord-303322-d69o3z8d 249 19 for for IN cord-303322-d69o3z8d 249 20 supporting support VBG cord-303322-d69o3z8d 249 21 this this DT cord-303322-d69o3z8d 249 22 study study NN cord-303322-d69o3z8d 249 23 and and CC cord-303322-d69o3z8d 249 24 for for IN cord-303322-d69o3z8d 249 25 over over RB cord-303322-d69o3z8d 249 26 - - HYPH cord-303322-d69o3z8d 249 27 seeing see VBG cord-303322-d69o3z8d 249 28 the the DT cord-303322-d69o3z8d 249 29 cultural cultural JJ cord-303322-d69o3z8d 249 30 aspects aspect NNS cord-303322-d69o3z8d 249 31 . . . cord-303322-d69o3z8d 250 1 We -PRON- PRP cord-303322-d69o3z8d 250 2 also also RB cord-303322-d69o3z8d 250 3 thank thank VBP cord-303322-d69o3z8d 250 4 Drs Drs NNP cord-303322-d69o3z8d 250 5 KA KA NNP cord-303322-d69o3z8d 250 6 O'Grady O'Grady NNP cord-303322-d69o3z8d 250 7 , , , cord-303322-d69o3z8d 250 8 Alan Alan NNP cord-303322-d69o3z8d 250 9 Isles Isles NNP cord-303322-d69o3z8d 250 10 , , , cord-303322-d69o3z8d 250 11 Alan Alan NNP cord-303322-d69o3z8d 250 12 Ruben Ruben NNP cord-303322-d69o3z8d 250 13 and and CC cord-303322-d69o3z8d 250 14 William William NNP cord-303322-d69o3z8d 250 15 Frischman Frischman NNP cord-303322-d69o3z8d 250 16 for for IN cord-303322-d69o3z8d 250 17 voluntarily voluntarily RB cord-303322-d69o3z8d 250 18 providing provide VBG cord-303322-d69o3z8d 250 19 their -PRON- PRP$ cord-303322-d69o3z8d 250 20 time time NN cord-303322-d69o3z8d 250 21 in in IN cord-303322-d69o3z8d 250 22 their -PRON- PRP$ cord-303322-d69o3z8d 250 23 participation participation NN cord-303322-d69o3z8d 250 24 in in IN cord-303322-d69o3z8d 250 25 the the DT cord-303322-d69o3z8d 250 26 study study NN cord-303322-d69o3z8d 250 27 's 's POS cord-303322-d69o3z8d 250 28 data data NN cord-303322-d69o3z8d 250 29 safety safety NNP cord-303322-d69o3z8d 250 30 monitoring monitoring NNP cord-303322-d69o3z8d 250 31 committee committee NNP cord-303322-d69o3z8d 250 32 . . . cord-303322-d69o3z8d 251 1 We -PRON- PRP cord-303322-d69o3z8d 251 2 are be VBP cord-303322-d69o3z8d 251 3 also also RB cord-303322-d69o3z8d 251 4 very very RB cord-303322-d69o3z8d 251 5 appreciative appreciative JJ cord-303322-d69o3z8d 251 6 to to IN cord-303322-d69o3z8d 251 7 the the DT cord-303322-d69o3z8d 251 8 Channel Channel NNP cord-303322-d69o3z8d 251 9 7 7 CD cord-303322-d69o3z8d 251 10 Children Children NNP cord-303322-d69o3z8d 251 11 's 's POS cord-303322-d69o3z8d 251 12 Foundation Foundation NNP cord-303322-d69o3z8d 251 13 and and CC cord-303322-d69o3z8d 251 14 the the DT cord-303322-d69o3z8d 251 15 Financial Financial NNP cord-303322-d69o3z8d 251 16 Markets Markets NNPS cord-303322-d69o3z8d 251 17 Foundation Foundation NNP cord-303322-d69o3z8d 251 18 for for IN cord-303322-d69o3z8d 251 19 Children child NNS cord-303322-d69o3z8d 251 20 for for IN cord-303322-d69o3z8d 251 21 funding fund VBG cord-303322-d69o3z8d 251 22 the the DT cord-303322-d69o3z8d 251 23 preliminary preliminary JJ cord-303322-d69o3z8d 251 24 study study NN cord-303322-d69o3z8d 251 25 that that WDT cord-303322-d69o3z8d 251 26 provided provide VBD cord-303322-d69o3z8d 251 27 us -PRON- PRP cord-303322-d69o3z8d 251 28 with with IN cord-303322-d69o3z8d 251 29 essential essential JJ cord-303322-d69o3z8d 251 30 pilot pilot NN cord-303322-d69o3z8d 251 31 data datum NNS cord-303322-d69o3z8d 251 32 for for IN cord-303322-d69o3z8d 251 33 our -PRON- PRP$ cord-303322-d69o3z8d 251 34 successful successful JJ cord-303322-d69o3z8d 251 35 NHMRC NHMRC NNP cord-303322-d69o3z8d 251 36 grant grant NN cord-303322-d69o3z8d 251 37 submission submission NN cord-303322-d69o3z8d 251 38 . . . cord-303322-d69o3z8d 252 1 Funding Funding NNP cord-303322-d69o3z8d 252 2 Study Study NNP cord-303322-d69o3z8d 252 3 is be VBZ cord-303322-d69o3z8d 252 4 funded fund VBN cord-303322-d69o3z8d 252 5 by by IN cord-303322-d69o3z8d 252 6 a a DT cord-303322-d69o3z8d 252 7 3-year 3-year JJ cord-303322-d69o3z8d 252 8 Australian Australian NNP cord-303322-d69o3z8d 252 9 National National NNP cord-303322-d69o3z8d 252 10 Health Health NNP cord-303322-d69o3z8d 252 11 and and CC cord-303322-d69o3z8d 252 12 Medical Medical NNP cord-303322-d69o3z8d 252 13 Research Research NNP cord-303322-d69o3z8d 252 14 Council Council NNP cord-303322-d69o3z8d 252 15 ( ( -LRB- cord-303322-d69o3z8d 252 16 NHMRC NHMRC NNP cord-303322-d69o3z8d 252 17 ) ) -RRB- cord-303322-d69o3z8d 252 18 project project NN cord-303322-d69o3z8d 252 19 grant grant NN cord-303322-d69o3z8d 252 20 ( ( -LRB- cord-303322-d69o3z8d 252 21 605809 605809 CD cord-303322-d69o3z8d 252 22 ) ) -RRB- cord-303322-d69o3z8d 252 23 . . . cord-303322-d69o3z8d 253 1 ABC ABC NNP cord-303322-d69o3z8d 253 2 is be VBZ cord-303322-d69o3z8d 253 3 supported support VBN cord-303322-d69o3z8d 253 4 by by IN cord-303322-d69o3z8d 253 5 a a DT cord-303322-d69o3z8d 253 6 NHMRC NHMRC NNP cord-303322-d69o3z8d 253 7 fellowship fellowship NN cord-303322-d69o3z8d 253 8 ( ( -LRB- cord-303322-d69o3z8d 253 9 545216 545216 CD cord-303322-d69o3z8d 253 10 ) ) -RRB- cord-303322-d69o3z8d 253 11 . . . cord-303322-d69o3z8d 254 1 Authors author NNS cord-303322-d69o3z8d 254 2 ' ' POS cord-303322-d69o3z8d 254 3 contributions contribution NNS cord-303322-d69o3z8d 254 4 AC AC NNP cord-303322-d69o3z8d 254 5 conceived conceive VBD cord-303322-d69o3z8d 254 6 the the DT cord-303322-d69o3z8d 254 7 study study NN cord-303322-d69o3z8d 254 8 , , , cord-303322-d69o3z8d 254 9 and and CC cord-303322-d69o3z8d 254 10 participated participate VBD cord-303322-d69o3z8d 254 11 in in IN cord-303322-d69o3z8d 254 12 its -PRON- PRP$ cord-303322-d69o3z8d 254 13 design design NN cord-303322-d69o3z8d 254 14 and and CC cord-303322-d69o3z8d 254 15 coordination coordination NN cord-303322-d69o3z8d 254 16 and and CC cord-303322-d69o3z8d 254 17 drafted draft VBD cord-303322-d69o3z8d 254 18 the the DT cord-303322-d69o3z8d 254 19 manuscript manuscript NN cord-303322-d69o3z8d 254 20 . . . cord-303322-d69o3z8d 255 1 PM PM NNP cord-303322-d69o3z8d 255 2 , , , cord-303322-d69o3z8d 255 3 KG KG NNP cord-303322-d69o3z8d 255 4 , , , cord-303322-d69o3z8d 255 5 TS TS NNP cord-303322-d69o3z8d 255 6 , , , cord-303322-d69o3z8d 255 7 AW AW NNP cord-303322-d69o3z8d 255 8 , , , cord-303322-d69o3z8d 255 9 AS AS NNP cord-303322-d69o3z8d 255 10 , , , cord-303322-d69o3z8d 255 11 CM CM NNP cord-303322-d69o3z8d 255 12 participated participate VBD cord-303322-d69o3z8d 255 13 in in IN cord-303322-d69o3z8d 255 14 its -PRON- PRP$ cord-303322-d69o3z8d 255 15 design design NN cord-303322-d69o3z8d 255 16 , , , cord-303322-d69o3z8d 255 17 analysis analysis NN cord-303322-d69o3z8d 255 18 plan plan NN cord-303322-d69o3z8d 255 19 and and CC cord-303322-d69o3z8d 255 20 submission submission NN cord-303322-d69o3z8d 255 21 to to IN cord-303322-d69o3z8d 255 22 the the DT cord-303322-d69o3z8d 255 23 NHMRC NHMRC NNP cord-303322-d69o3z8d 255 24 . . . cord-303322-d69o3z8d 256 1 GM GM NNP cord-303322-d69o3z8d 256 2 participated participate VBD cord-303322-d69o3z8d 256 3 in in IN cord-303322-d69o3z8d 256 4 initiating initiate VBG cord-303322-d69o3z8d 256 5 and and CC cord-303322-d69o3z8d 256 6 running run VBG cord-303322-d69o3z8d 256 7 the the DT cord-303322-d69o3z8d 256 8 project project NN cord-303322-d69o3z8d 256 9 and and CC cord-303322-d69o3z8d 256 10 IM IM NNP cord-303322-d69o3z8d 256 11 in in IN cord-303322-d69o3z8d 256 12 the the DT cord-303322-d69o3z8d 256 13 viral viral JJ cord-303322-d69o3z8d 256 14 analysis analysis NN cord-303322-d69o3z8d 256 15 plan plan NN cord-303322-d69o3z8d 256 16 . . . cord-303322-d69o3z8d 257 1 All all DT cord-303322-d69o3z8d 257 2 authors author NNS cord-303322-d69o3z8d 257 3 read read VBP cord-303322-d69o3z8d 257 4 and and CC cord-303322-d69o3z8d 257 5 approved approve VBD cord-303322-d69o3z8d 257 6 the the DT cord-303322-d69o3z8d 257 7 final final JJ cord-303322-d69o3z8d 257 8 manuscript manuscript NN cord-303322-d69o3z8d 257 9 . . . cord-303322-d69o3z8d 258 1 The the DT cord-303322-d69o3z8d 258 2 authors author NNS cord-303322-d69o3z8d 258 3 declare declare VBP cord-303322-d69o3z8d 258 4 that that IN cord-303322-d69o3z8d 258 5 they -PRON- PRP cord-303322-d69o3z8d 258 6 have have VBP cord-303322-d69o3z8d 258 7 no no DT cord-303322-d69o3z8d 258 8 competing compete VBG cord-303322-d69o3z8d 258 9 interests interest NNS cord-303322-d69o3z8d 258 10 . . . cord-303322-d69o3z8d 258 11 _SP