id sid tid token lemma pos cord-269652-t7ghng17 1 1 key key JJ cord-269652-t7ghng17 1 2 : : : cord-269652-t7ghng17 1 3 cord-269652-t7ghng17 cord-269652-t7ghng17 VBN cord-269652-t7ghng17 1 4 authors author NNS cord-269652-t7ghng17 1 5 : : : cord-269652-t7ghng17 1 6 Santos Santos NNP cord-269652-t7ghng17 1 7 , , , cord-269652-t7ghng17 1 8 Roberto Roberto NNP cord-269652-t7ghng17 1 9 Parulan Parulan NNP cord-269652-t7ghng17 1 10 ; ; : cord-269652-t7ghng17 1 11 Tristram Tristram NNP cord-269652-t7ghng17 1 12 , , , cord-269652-t7ghng17 1 13 Debra Debra NNP cord-269652-t7ghng17 1 14 title title NN cord-269652-t7ghng17 1 15 : : : cord-269652-t7ghng17 1 16 A a DT cord-269652-t7ghng17 1 17 Practical Practical NNP cord-269652-t7ghng17 1 18 Guide Guide NNP cord-269652-t7ghng17 1 19 to to IN cord-269652-t7ghng17 1 20 the the DT cord-269652-t7ghng17 1 21 Diagnosis Diagnosis NNP cord-269652-t7ghng17 1 22 , , , cord-269652-t7ghng17 1 23 Treatment Treatment NNP cord-269652-t7ghng17 1 24 , , , cord-269652-t7ghng17 1 25 and and CC cord-269652-t7ghng17 1 26 Prevention Prevention NNP cord-269652-t7ghng17 1 27 of of IN cord-269652-t7ghng17 1 28 Neonatal Neonatal NNP cord-269652-t7ghng17 1 29 Infections Infections NNPS cord-269652-t7ghng17 1 30 date date NN cord-269652-t7ghng17 1 31 : : : cord-269652-t7ghng17 1 32 2015 2015 CD cord-269652-t7ghng17 1 33 - - HYPH cord-269652-t7ghng17 1 34 04 04 CD cord-269652-t7ghng17 1 35 - - SYM cord-269652-t7ghng17 1 36 30 30 CD cord-269652-t7ghng17 1 37 journal journal NN cord-269652-t7ghng17 1 38 : : : cord-269652-t7ghng17 1 39 Pediatric Pediatric NNP cord-269652-t7ghng17 1 40 Clinics Clinics NNPS cord-269652-t7ghng17 1 41 of of IN cord-269652-t7ghng17 1 42 North North NNP cord-269652-t7ghng17 1 43 America America NNP cord-269652-t7ghng17 2 1 DOI DOI NNP cord-269652-t7ghng17 2 2 : : : cord-269652-t7ghng17 2 3 10.1016/ 10.1016/ CD cord-269652-t7ghng17 3 1 j.pcl.2014.11.010 j.pcl.2014.11.010 NNP cord-269652-t7ghng17 3 2 sha sha NNP cord-269652-t7ghng17 3 3 : : : cord-269652-t7ghng17 4 1 6659e6eafbeebde5b39d9a5a115793e7071649dc 6659e6eafbeebde5b39d9a5a115793e7071649dc CD cord-269652-t7ghng17 4 2 doc_id doc_id CD cord-269652-t7ghng17 5 1 : : : cord-269652-t7ghng17 5 2 269652 269652 CD cord-269652-t7ghng17 5 3 cord_uid cord_uid NNS cord-269652-t7ghng17 5 4 : : : cord-269652-t7ghng17 6 1 t7ghng17 t7ghng17 NNP cord-269652-t7ghng17 6 2 Neonatal neonatal JJ cord-269652-t7ghng17 6 3 infections infection NNS cord-269652-t7ghng17 6 4 continue continue VBP cord-269652-t7ghng17 6 5 to to TO cord-269652-t7ghng17 6 6 cause cause VB cord-269652-t7ghng17 6 7 morbidity morbidity NN cord-269652-t7ghng17 6 8 and and CC cord-269652-t7ghng17 6 9 mortality mortality NN cord-269652-t7ghng17 6 10 in in IN cord-269652-t7ghng17 6 11 infants infant NNS cord-269652-t7ghng17 6 12 . . . cord-269652-t7ghng17 7 1 Among among IN cord-269652-t7ghng17 7 2 approximately approximately RB cord-269652-t7ghng17 7 3 400,000 400,000 CD cord-269652-t7ghng17 7 4 infants infant NNS cord-269652-t7ghng17 7 5 followed follow VBD cord-269652-t7ghng17 7 6 nationally nationally RB cord-269652-t7ghng17 7 7 , , , cord-269652-t7ghng17 7 8 the the DT cord-269652-t7ghng17 7 9 incidence incidence NN cord-269652-t7ghng17 7 10 rates rate NNS cord-269652-t7ghng17 7 11 of of IN cord-269652-t7ghng17 7 12 early early JJ cord-269652-t7ghng17 7 13 - - HYPH cord-269652-t7ghng17 7 14 onset onset NN cord-269652-t7ghng17 7 15 sepsis sepsis NN cord-269652-t7ghng17 7 16 infection infection NN cord-269652-t7ghng17 7 17 within within IN cord-269652-t7ghng17 7 18 3 3 CD cord-269652-t7ghng17 7 19 days day NNS cord-269652-t7ghng17 7 20 of of IN cord-269652-t7ghng17 7 21 life life NN cord-269652-t7ghng17 7 22 are be VBP cord-269652-t7ghng17 7 23 0.98 0.98 CD cord-269652-t7ghng17 7 24 cases case NNS cord-269652-t7ghng17 7 25 per per IN cord-269652-t7ghng17 7 26 1000 1000 CD cord-269652-t7ghng17 7 27 live live JJ cord-269652-t7ghng17 7 28 births birth NNS cord-269652-t7ghng17 7 29 . . . cord-269652-t7ghng17 8 1 Newborn newborn JJ cord-269652-t7ghng17 8 2 infants infant NNS cord-269652-t7ghng17 8 3 are be VBP cord-269652-t7ghng17 8 4 at at IN cord-269652-t7ghng17 8 5 increased increase VBN cord-269652-t7ghng17 8 6 risk risk NN cord-269652-t7ghng17 8 7 for for IN cord-269652-t7ghng17 8 8 infections infection NNS cord-269652-t7ghng17 8 9 because because IN cord-269652-t7ghng17 8 10 they -PRON- PRP cord-269652-t7ghng17 8 11 have have VBP cord-269652-t7ghng17 8 12 relative relative JJ cord-269652-t7ghng17 8 13 immunodeficiency immunodeficiency NN cord-269652-t7ghng17 8 14 . . . cord-269652-t7ghng17 9 1 This this DT cord-269652-t7ghng17 9 2 article article NN cord-269652-t7ghng17 9 3 provides provide VBZ cord-269652-t7ghng17 9 4 evidence evidence NN cord-269652-t7ghng17 9 5 - - HYPH cord-269652-t7ghng17 9 6 based base VBN cord-269652-t7ghng17 9 7 practical practical JJ cord-269652-t7ghng17 9 8 approaches approach NNS cord-269652-t7ghng17 9 9 to to IN cord-269652-t7ghng17 9 10 the the DT cord-269652-t7ghng17 9 11 diagnosis diagnosis NN cord-269652-t7ghng17 9 12 , , , cord-269652-t7ghng17 9 13 management management NN cord-269652-t7ghng17 9 14 , , , cord-269652-t7ghng17 9 15 and and CC cord-269652-t7ghng17 9 16 prevention prevention NN cord-269652-t7ghng17 9 17 of of IN cord-269652-t7ghng17 9 18 neonatal neonatal JJ cord-269652-t7ghng17 9 19 infections infection NNS cord-269652-t7ghng17 9 20 . . . cord-269652-t7ghng17 10 1 Neonatal neonatal JJ cord-269652-t7ghng17 10 2 infections infection NNS cord-269652-t7ghng17 10 3 continue continue VBP cord-269652-t7ghng17 10 4 to to TO cord-269652-t7ghng17 10 5 cause cause VB cord-269652-t7ghng17 10 6 morbidity morbidity NN cord-269652-t7ghng17 10 7 and and CC cord-269652-t7ghng17 10 8 mortality mortality NN cord-269652-t7ghng17 10 9 in in IN cord-269652-t7ghng17 10 10 infants infant NNS cord-269652-t7ghng17 10 11 . . . cord-269652-t7ghng17 11 1 Among among IN cord-269652-t7ghng17 11 2 approximately approximately RB cord-269652-t7ghng17 11 3 400,000 400,000 CD cord-269652-t7ghng17 11 4 infants infant NNS cord-269652-t7ghng17 11 5 followed follow VBD cord-269652-t7ghng17 11 6 nationally nationally RB cord-269652-t7ghng17 11 7 , , , cord-269652-t7ghng17 11 8 the the DT cord-269652-t7ghng17 11 9 incidence incidence NN cord-269652-t7ghng17 11 10 rates rate NNS cord-269652-t7ghng17 11 11 of of IN cord-269652-t7ghng17 11 12 early early JJ cord-269652-t7ghng17 11 13 - - HYPH cord-269652-t7ghng17 11 14 onset onset NN cord-269652-t7ghng17 11 15 sepsis sepsis NN cord-269652-t7ghng17 11 16 ( ( -LRB- cord-269652-t7ghng17 11 17 EOS EOS NNP cord-269652-t7ghng17 11 18 ) ) -RRB- cord-269652-t7ghng17 11 19 infection infection NN cord-269652-t7ghng17 11 20 within within IN cord-269652-t7ghng17 11 21 3 3 CD cord-269652-t7ghng17 11 22 days day NNS cord-269652-t7ghng17 11 23 of of IN cord-269652-t7ghng17 11 24 life life NN cord-269652-t7ghng17 11 25 were be VBD cord-269652-t7ghng17 11 26 0.98 0.98 CD cord-269652-t7ghng17 11 27 cases case NNS cord-269652-t7ghng17 11 28 per per IN cord-269652-t7ghng17 11 29 1000 1000 CD cord-269652-t7ghng17 11 30 live live JJ cord-269652-t7ghng17 11 31 births birth NNS cord-269652-t7ghng17 11 32 . . . cord-269652-t7ghng17 12 1 1 1 LS cord-269652-t7ghng17 12 2 More More JJR cord-269652-t7ghng17 12 3 than than IN cord-269652-t7ghng17 12 4 two two CD cord-269652-t7ghng17 12 5 - - HYPH cord-269652-t7ghng17 12 6 thirds third NNS cord-269652-t7ghng17 12 7 of of IN cord-269652-t7ghng17 12 8 the the DT cord-269652-t7ghng17 12 9 frequently frequently RB cord-269652-t7ghng17 12 10 isolated isolate VBN cord-269652-t7ghng17 12 11 organisms organism NNS cord-269652-t7ghng17 12 12 were be VBD cord-269652-t7ghng17 12 13 associated associate VBN cord-269652-t7ghng17 12 14 with with IN cord-269652-t7ghng17 12 15 group group NN cord-269652-t7ghng17 12 16 B b NN cord-269652-t7ghng17 12 17 streptococcus streptococcus NN cord-269652-t7ghng17 12 18 ( ( -LRB- cord-269652-t7ghng17 12 19 GBS GBS NNP cord-269652-t7ghng17 12 20 ) ) -RRB- cord-269652-t7ghng17 12 21 ( ( -LRB- cord-269652-t7ghng17 12 22 43 43 CD cord-269652-t7ghng17 12 23 % % NN cord-269652-t7ghng17 12 24 ) ) -RRB- cord-269652-t7ghng17 12 25 and and CC cord-269652-t7ghng17 12 26 Escherichia Escherichia NNP cord-269652-t7ghng17 12 27 coli coli NNS cord-269652-t7ghng17 12 28 ( ( -LRB- cord-269652-t7ghng17 12 29 29 29 CD cord-269652-t7ghng17 12 30 % % NN cord-269652-t7ghng17 12 31 ) ) -RRB- cord-269652-t7ghng17 12 32 . . . cord-269652-t7ghng17 13 1 Although although IN cord-269652-t7ghng17 13 2 20 20 CD cord-269652-t7ghng17 13 3 % % NN cord-269652-t7ghng17 13 4 of of IN cord-269652-t7ghng17 13 5 the the DT cord-269652-t7ghng17 13 6 term term NN cord-269652-t7ghng17 13 7 infants infant NNS cord-269652-t7ghng17 13 8 were be VBD cord-269652-t7ghng17 13 9 treated treat VBN cord-269652-t7ghng17 13 10 in in IN cord-269652-t7ghng17 13 11 the the DT cord-269652-t7ghng17 13 12 newborn newborn JJ cord-269652-t7ghng17 13 13 nursery nursery NN cord-269652-t7ghng17 13 14 , , , cord-269652-t7ghng17 13 15 77 77 CD cord-269652-t7ghng17 13 16 % % NN cord-269652-t7ghng17 13 17 of of IN cord-269652-t7ghng17 13 18 the the DT cord-269652-t7ghng17 13 19 infected infect VBN cord-269652-t7ghng17 13 20 infants infant NNS cord-269652-t7ghng17 13 21 required require VBD cord-269652-t7ghng17 13 22 intensive intensive JJ cord-269652-t7ghng17 13 23 care care NN cord-269652-t7ghng17 13 24 management management NN cord-269652-t7ghng17 13 25 . . . cord-269652-t7ghng17 14 1 Of of IN cord-269652-t7ghng17 14 2 those those DT cord-269652-t7ghng17 14 3 who who WP cord-269652-t7ghng17 14 4 survived survive VBD cord-269652-t7ghng17 14 5 beyond beyond IN cord-269652-t7ghng17 14 6 3 3 CD cord-269652-t7ghng17 14 7 days day NNS cord-269652-t7ghng17 14 8 of of IN cord-269652-t7ghng17 14 9 life life NN cord-269652-t7ghng17 14 10 , , , cord-269652-t7ghng17 14 11 about about RB cord-269652-t7ghng17 14 12 21 21 CD cord-269652-t7ghng17 14 13 % % NN cord-269652-t7ghng17 14 14 had have VBD cord-269652-t7ghng17 14 15 an an DT cord-269652-t7ghng17 14 16 episode episode NN cord-269652-t7ghng17 14 17 of of IN cord-269652-t7ghng17 14 18 late late JJ cord-269652-t7ghng17 14 19 - - HYPH cord-269652-t7ghng17 14 20 onset onset NN cord-269652-t7ghng17 14 21 sepsis sepsis NN cord-269652-t7ghng17 14 22 ( ( -LRB- cord-269652-t7ghng17 14 23 LOS LOS NNP cord-269652-t7ghng17 14 24 ) ) -RRB- cord-269652-t7ghng17 14 25 infection infection NN cord-269652-t7ghng17 14 26 after after IN cord-269652-t7ghng17 14 27 3 3 CD cord-269652-t7ghng17 14 28 days day NNS cord-269652-t7ghng17 14 29 of of IN cord-269652-t7ghng17 14 30 life life NN cord-269652-t7ghng17 14 31 . . . cord-269652-t7ghng17 15 1 The the DT cord-269652-t7ghng17 15 2 overall overall JJ cord-269652-t7ghng17 15 3 mortality mortality NN cord-269652-t7ghng17 15 4 rate rate NN cord-269652-t7ghng17 15 5 of of IN cord-269652-t7ghng17 15 6 infected infected JJ cord-269652-t7ghng17 15 7 infants infant NNS cord-269652-t7ghng17 15 8 was be VBD cord-269652-t7ghng17 15 9 16 16 CD cord-269652-t7ghng17 15 10 % % NN cord-269652-t7ghng17 15 11 . . . cord-269652-t7ghng17 16 1 Newborn newborn JJ cord-269652-t7ghng17 16 2 infants infant NNS cord-269652-t7ghng17 16 3 are be VBP cord-269652-t7ghng17 16 4 at at IN cord-269652-t7ghng17 16 5 increased increase VBN cord-269652-t7ghng17 16 6 risk risk NN cord-269652-t7ghng17 16 7 for for IN cord-269652-t7ghng17 16 8 infections infection NNS cord-269652-t7ghng17 16 9 because because IN cord-269652-t7ghng17 16 10 they -PRON- PRP cord-269652-t7ghng17 16 11 have have VBP cord-269652-t7ghng17 16 12 relative relative JJ cord-269652-t7ghng17 16 13 immunodeficiency immunodeficiency NN cord-269652-t7ghng17 16 14 . . . cord-269652-t7ghng17 17 1 This this DT cord-269652-t7ghng17 17 2 may may MD cord-269652-t7ghng17 17 3 be be VB cord-269652-t7ghng17 17 4 due due JJ cord-269652-t7ghng17 17 5 to to IN cord-269652-t7ghng17 17 6 decreased decrease VBN cord-269652-t7ghng17 17 7 passage passage NN cord-269652-t7ghng17 17 8 of of IN cord-269652-t7ghng17 17 9 maternal maternal JJ cord-269652-t7ghng17 17 10 antibodies antibody NNS cord-269652-t7ghng17 17 11 in in IN cord-269652-t7ghng17 17 12 preterm preterm JJ cord-269652-t7ghng17 17 13 infants infant NNS cord-269652-t7ghng17 17 14 and and CC cord-269652-t7ghng17 17 15 to to IN cord-269652-t7ghng17 17 16 immaturity immaturity NN cord-269652-t7ghng17 17 17 of of IN cord-269652-t7ghng17 17 18 the the DT cord-269652-t7ghng17 17 19 immune immune JJ cord-269652-t7ghng17 17 20 system system NN cord-269652-t7ghng17 17 21 in in IN cord-269652-t7ghng17 17 22 general general JJ cord-269652-t7ghng17 17 23 . . . cord-269652-t7ghng17 18 1 2 2 LS cord-269652-t7ghng17 18 2 , , , cord-269652-t7ghng17 18 3 3 3 CD cord-269652-t7ghng17 19 1 The the DT cord-269652-t7ghng17 19 2 innate innate JJ cord-269652-t7ghng17 19 3 immune immune JJ cord-269652-t7ghng17 19 4 functions function NNS cord-269652-t7ghng17 19 5 in in IN cord-269652-t7ghng17 19 6 infants infant NNS cord-269652-t7ghng17 19 7 are be VBP cord-269652-t7ghng17 19 8 impaired impair VBN cord-269652-t7ghng17 19 9 with with IN cord-269652-t7ghng17 19 10 decreased decrease VBN cord-269652-t7ghng17 19 11 production production NN cord-269652-t7ghng17 19 12 of of IN cord-269652-t7ghng17 19 13 inflammatory inflammatory JJ cord-269652-t7ghng17 19 14 markers marker NNS cord-269652-t7ghng17 19 15 ( ( -LRB- cord-269652-t7ghng17 19 16 interleukin interleukin NN cord-269652-t7ghng17 19 17 6 6 CD cord-269652-t7ghng17 19 18 and and CC cord-269652-t7ghng17 19 19 tumor tumor NN cord-269652-t7ghng17 19 20 necrosis necrosis NN cord-269652-t7ghng17 19 21 factor factor NN cord-269652-t7ghng17 19 22 ) ) -RRB- cord-269652-t7ghng17 19 23 4 4 CD cord-269652-t7ghng17 19 24 and and CC cord-269652-t7ghng17 19 25 with with IN cord-269652-t7ghng17 19 26 decreased decrease VBN cord-269652-t7ghng17 19 27 dendritic dendritic JJ cord-269652-t7ghng17 19 28 and and CC cord-269652-t7ghng17 19 29 neutrophil neutrophil NN cord-269652-t7ghng17 19 30 functions function NNS cord-269652-t7ghng17 19 31 . . . cord-269652-t7ghng17 20 1 5 5 LS cord-269652-t7ghng17 21 1 The the DT cord-269652-t7ghng17 21 2 adaptive adaptive JJ cord-269652-t7ghng17 21 3 immune immune JJ cord-269652-t7ghng17 21 4 system system NN cord-269652-t7ghng17 21 5 is be VBZ cord-269652-t7ghng17 21 6 less less JJR cord-269652-t7ghng17 21 7 than than IN cord-269652-t7ghng17 21 8 optimal optimal JJ cord-269652-t7ghng17 21 9 with with IN cord-269652-t7ghng17 21 10 decreased decreased JJ cord-269652-t7ghng17 21 11 cytotoxic cytotoxic JJ cord-269652-t7ghng17 21 12 functions function NNS cord-269652-t7ghng17 21 13 , , , cord-269652-t7ghng17 21 14 2 2 CD cord-269652-t7ghng17 21 15 decreased decrease VBD cord-269652-t7ghng17 21 16 cell cell NN cord-269652-t7ghng17 21 17 mediated mediate VBN cord-269652-t7ghng17 21 18 immunity immunity NN cord-269652-t7ghng17 21 19 , , , cord-269652-t7ghng17 21 20 6 6 CD cord-269652-t7ghng17 21 21 and and CC cord-269652-t7ghng17 21 22 delayed delay VBN cord-269652-t7ghng17 21 23 or or CC cord-269652-t7ghng17 21 24 lack lack NN cord-269652-t7ghng17 21 25 of of IN cord-269652-t7ghng17 21 26 isotype isotype NN cord-269652-t7ghng17 21 27 switching switching NN cord-269652-t7ghng17 21 28 . . . cord-269652-t7ghng17 22 1 2 2 LS cord-269652-t7ghng17 22 2 , , , cord-269652-t7ghng17 22 3 3 3 CD cord-269652-t7ghng17 22 4 Complement complement NN cord-269652-t7ghng17 22 5 is be VBZ cord-269652-t7ghng17 22 6 important important JJ cord-269652-t7ghng17 22 7 in in IN cord-269652-t7ghng17 22 8 opsonization opsonization NN cord-269652-t7ghng17 22 9 and and CC cord-269652-t7ghng17 22 10 bacterial bacterial JJ cord-269652-t7ghng17 22 11 killing killing NN cord-269652-t7ghng17 22 12 . . . cord-269652-t7ghng17 23 1 In in IN cord-269652-t7ghng17 23 2 term term NN cord-269652-t7ghng17 23 3 infants infant NNS cord-269652-t7ghng17 23 4 , , , cord-269652-t7ghng17 23 5 complement complement JJ cord-269652-t7ghng17 23 6 levels level NNS cord-269652-t7ghng17 23 7 are be VBP cord-269652-t7ghng17 23 8 approximately approximately RB cord-269652-t7ghng17 23 9 half half RB cord-269652-t7ghng17 23 10 compared compare VBN cord-269652-t7ghng17 23 11 with with IN cord-269652-t7ghng17 23 12 adults adult NNS cord-269652-t7ghng17 23 13 . . . cord-269652-t7ghng17 24 1 2 2 LS cord-269652-t7ghng17 24 2 Taken take VBN cord-269652-t7ghng17 24 3 together together RB cord-269652-t7ghng17 24 4 , , , cord-269652-t7ghng17 24 5 these these DT cord-269652-t7ghng17 24 6 predispose predispose VBP cord-269652-t7ghng17 24 7 infants infant NNS cord-269652-t7ghng17 24 8 to to TO cord-269652-t7ghng17 24 9 severe severe JJ cord-269652-t7ghng17 24 10 , , , cord-269652-t7ghng17 24 11 prolonged prolonged JJ cord-269652-t7ghng17 24 12 , , , cord-269652-t7ghng17 24 13 or or CC cord-269652-t7ghng17 24 14 recurrent recurrent JJ cord-269652-t7ghng17 24 15 infections infection NNS cord-269652-t7ghng17 24 16 associated associate VBN cord-269652-t7ghng17 24 17 with with IN cord-269652-t7ghng17 24 18 bacterial bacterial JJ cord-269652-t7ghng17 24 19 , , , cord-269652-t7ghng17 24 20 viral viral JJ cord-269652-t7ghng17 24 21 , , , cord-269652-t7ghng17 24 22 or or CC cord-269652-t7ghng17 24 23 fungal fungal JJ cord-269652-t7ghng17 24 24 infections infection NNS cord-269652-t7ghng17 24 25 . . . cord-269652-t7ghng17 25 1 Suspected suspect VBN cord-269652-t7ghng17 25 2 sepsis sepsis NN cord-269652-t7ghng17 25 3 , , , cord-269652-t7ghng17 25 4 presumed presume VBN cord-269652-t7ghng17 25 5 infection infection NN cord-269652-t7ghng17 25 6 , , , cord-269652-t7ghng17 25 7 and and CC cord-269652-t7ghng17 25 8 ruling rule VBG cord-269652-t7ghng17 25 9 out out RP cord-269652-t7ghng17 25 10 sepsis sepsis NN cord-269652-t7ghng17 25 11 remain remain VBP cord-269652-t7ghng17 25 12 the the DT cord-269652-t7ghng17 25 13 most most RBS cord-269652-t7ghng17 25 14 common common JJ cord-269652-t7ghng17 25 15 diagnoses diagnosis NNS cord-269652-t7ghng17 25 16 in in IN cord-269652-t7ghng17 25 17 the the DT cord-269652-t7ghng17 25 18 nursery nursery NN cord-269652-t7ghng17 25 19 intensive intensive JJ cord-269652-t7ghng17 25 20 care care NN cord-269652-t7ghng17 25 21 unit unit NN cord-269652-t7ghng17 25 22 ( ( -LRB- cord-269652-t7ghng17 25 23 NICU NICU NNP cord-269652-t7ghng17 25 24 ) ) -RRB- cord-269652-t7ghng17 25 25 . . . cord-269652-t7ghng17 26 1 The the DT cord-269652-t7ghng17 26 2 American American NNP cord-269652-t7ghng17 26 3 Academy Academy NNP cord-269652-t7ghng17 26 4 of of IN cord-269652-t7ghng17 26 5 Pediatrics Pediatrics NNP cord-269652-t7ghng17 26 6 ( ( -LRB- cord-269652-t7ghng17 26 7 AAP AAP NNP cord-269652-t7ghng17 26 8 ) ) -RRB- cord-269652-t7ghng17 26 9 Committee Committee NNP cord-269652-t7ghng17 26 10 on on IN cord-269652-t7ghng17 26 11 Fetus Fetus NNP cord-269652-t7ghng17 26 12 and and CC cord-269652-t7ghng17 26 13 Newborn Newborn NNP cord-269652-t7ghng17 26 14 7 7 CD cord-269652-t7ghng17 26 15 has have VBZ cord-269652-t7ghng17 26 16 published publish VBN cord-269652-t7ghng17 26 17 a a DT cord-269652-t7ghng17 26 18 clinical clinical JJ cord-269652-t7ghng17 26 19 report report NN cord-269652-t7ghng17 26 20 extensively extensively RB cord-269652-t7ghng17 26 21 discussing discuss VBG cord-269652-t7ghng17 26 22 clinically clinically RB cord-269652-t7ghng17 26 23 relevant relevant JJ cord-269652-t7ghng17 26 24 challenges challenge NNS cord-269652-t7ghng17 26 25 : : : cord-269652-t7ghng17 26 26 identifying identify VBG cord-269652-t7ghng17 26 27 newborns newborn NNS cord-269652-t7ghng17 26 28 with with IN cord-269652-t7ghng17 26 29 signs sign NNS cord-269652-t7ghng17 26 30 of of IN cord-269652-t7ghng17 26 31 sepsis sepsis NN cord-269652-t7ghng17 26 32 with with IN cord-269652-t7ghng17 26 33 high high JJ cord-269652-t7ghng17 26 34 likelihood likelihood NN cord-269652-t7ghng17 26 35 of of IN cord-269652-t7ghng17 26 36 EOS EOS NNP cord-269652-t7ghng17 26 37 requiring require VBG cord-269652-t7ghng17 26 38 antimicrobial antimicrobial JJ cord-269652-t7ghng17 26 39 regimen regimen NN cord-269652-t7ghng17 26 40 and and CC cord-269652-t7ghng17 26 41 identifying identify VBG cord-269652-t7ghng17 26 42 healthy healthy RB cord-269652-t7ghng17 26 43 - - HYPH cord-269652-t7ghng17 26 44 appearing appear VBG cord-269652-t7ghng17 26 45 newborns newborn NNS cord-269652-t7ghng17 26 46 with with IN cord-269652-t7ghng17 26 47 high high JJ cord-269652-t7ghng17 26 48 likelihood likelihood NN cord-269652-t7ghng17 26 49 of of IN cord-269652-t7ghng17 26 50 EOS EOS NNP cord-269652-t7ghng17 26 51 requiring require VBG cord-269652-t7ghng17 26 52 antimicrobial antimicrobial JJ cord-269652-t7ghng17 26 53 regimen regimen NN cord-269652-t7ghng17 26 54 . . . cord-269652-t7ghng17 27 1 The the DT cord-269652-t7ghng17 27 2 committee committee NN cord-269652-t7ghng17 27 3 concluded conclude VBD cord-269652-t7ghng17 27 4 that that IN cord-269652-t7ghng17 27 5 , , , cord-269652-t7ghng17 27 6 although although IN cord-269652-t7ghng17 27 7 these these DT cord-269652-t7ghng17 27 8 guidelines guideline NNS cord-269652-t7ghng17 27 9 are be VBP cord-269652-t7ghng17 27 10 evidencebased evidencebase VBN cord-269652-t7ghng17 27 11 , , , cord-269652-t7ghng17 27 12 they -PRON- PRP cord-269652-t7ghng17 27 13 may may MD cord-269652-t7ghng17 27 14 be be VB cord-269652-t7ghng17 27 15 modified modify VBN cord-269652-t7ghng17 27 16 by by IN cord-269652-t7ghng17 27 17 the the DT cord-269652-t7ghng17 27 18 clinical clinical JJ cord-269652-t7ghng17 27 19 judgment judgment NN cord-269652-t7ghng17 27 20 of of IN cord-269652-t7ghng17 27 21 the the DT cord-269652-t7ghng17 27 22 provider provider NN cord-269652-t7ghng17 27 23 . . . cord-269652-t7ghng17 28 1 The the DT cord-269652-t7ghng17 28 2 primary primary JJ cord-269652-t7ghng17 28 3 reason reason NN cord-269652-t7ghng17 28 4 is be VBZ cord-269652-t7ghng17 28 5 that that IN cord-269652-t7ghng17 28 6 the the DT cord-269652-t7ghng17 28 7 clinical clinical JJ cord-269652-t7ghng17 28 8 presentation presentation NN cord-269652-t7ghng17 28 9 of of IN cord-269652-t7ghng17 28 10 neonatal neonatal JJ cord-269652-t7ghng17 28 11 infection infection NN cord-269652-t7ghng17 28 12 may may MD cord-269652-t7ghng17 28 13 be be VB cord-269652-t7ghng17 28 14 subtle subtle JJ cord-269652-t7ghng17 28 15 and and CC cord-269652-t7ghng17 28 16 nonspecific nonspecific JJ cord-269652-t7ghng17 28 17 , , , cord-269652-t7ghng17 28 18 and and CC cord-269652-t7ghng17 28 19 may may MD cord-269652-t7ghng17 28 20 overlap overlap VB cord-269652-t7ghng17 28 21 with with IN cord-269652-t7ghng17 28 22 noninfectious noninfectious JJ cord-269652-t7ghng17 28 23 causes cause NNS cord-269652-t7ghng17 28 24 . . . cord-269652-t7ghng17 29 1 7 7 CD cord-269652-t7ghng17 30 1 , , , cord-269652-t7ghng17 30 2 8 8 CD cord-269652-t7ghng17 30 3 Many many JJ cord-269652-t7ghng17 30 4 clinicians clinician NNS cord-269652-t7ghng17 30 5 empirically empirically RB cord-269652-t7ghng17 30 6 start start VBP cord-269652-t7ghng17 30 7 broad broad JJ cord-269652-t7ghng17 30 8 spectrum spectrum NN cord-269652-t7ghng17 30 9 antimicrobial antimicrobial JJ cord-269652-t7ghng17 30 10 regimen regimen NN cord-269652-t7ghng17 30 11 for for IN cord-269652-t7ghng17 30 12 infants infant NNS cord-269652-t7ghng17 30 13 considered consider VBN cord-269652-t7ghng17 30 14 at at IN cord-269652-t7ghng17 30 15 risk risk NN cord-269652-t7ghng17 30 16 for for IN cord-269652-t7ghng17 30 17 sepsis sepsis NN cord-269652-t7ghng17 30 18 but but CC cord-269652-t7ghng17 30 19 antibiotics antibiotic NNS cord-269652-t7ghng17 30 20 are be VBP cord-269652-t7ghng17 30 21 occasionally occasionally RB cord-269652-t7ghng17 30 22 continued continue VBN cord-269652-t7ghng17 30 23 despite despite IN cord-269652-t7ghng17 30 24 a a DT cord-269652-t7ghng17 30 25 negative negative JJ cord-269652-t7ghng17 30 26 blood blood NN cord-269652-t7ghng17 30 27 culture culture NN cord-269652-t7ghng17 30 28 . . . cord-269652-t7ghng17 31 1 This this DT cord-269652-t7ghng17 31 2 practice practice NN cord-269652-t7ghng17 31 3 may may MD cord-269652-t7ghng17 31 4 be be VB cord-269652-t7ghng17 31 5 detrimental detrimental JJ cord-269652-t7ghng17 31 6 to to IN cord-269652-t7ghng17 31 7 the the DT cord-269652-t7ghng17 31 8 infant infant NN cord-269652-t7ghng17 31 9 8 8 CD cord-269652-t7ghng17 31 10 because because IN cord-269652-t7ghng17 31 11 it -PRON- PRP cord-269652-t7ghng17 31 12 increases increase VBZ cord-269652-t7ghng17 31 13 the the DT cord-269652-t7ghng17 31 14 risk risk NN cord-269652-t7ghng17 31 15 of of IN cord-269652-t7ghng17 31 16 invasive invasive JJ cord-269652-t7ghng17 31 17 fungal fungal JJ cord-269652-t7ghng17 31 18 infections infection NNS cord-269652-t7ghng17 31 19 , , , cord-269652-t7ghng17 31 20 9 9 CD cord-269652-t7ghng17 31 21 necrotizing necrotize VBG cord-269652-t7ghng17 31 22 enterocolitis enterocolitis NN cord-269652-t7ghng17 31 23 ( ( -LRB- cord-269652-t7ghng17 31 24 NEC NEC NNP cord-269652-t7ghng17 31 25 ) ) -RRB- cord-269652-t7ghng17 31 26 , , , cord-269652-t7ghng17 31 27 or or CC cord-269652-t7ghng17 31 28 death death NN cord-269652-t7ghng17 31 29 , , , cord-269652-t7ghng17 31 30 10 10 CD cord-269652-t7ghng17 31 31 , , , cord-269652-t7ghng17 31 32 11 11 CD cord-269652-t7ghng17 31 33 which which WDT cord-269652-t7ghng17 31 34 increases increase VBZ cord-269652-t7ghng17 31 35 the the DT cord-269652-t7ghng17 31 36 pressure pressure NN cord-269652-t7ghng17 31 37 for for IN cord-269652-t7ghng17 31 38 selecting select VBG cord-269652-t7ghng17 31 39 multidrug multidrug NN cord-269652-t7ghng17 31 40 - - HYPH cord-269652-t7ghng17 31 41 resistant resistant JJ cord-269652-t7ghng17 31 42 organisms organism NNS cord-269652-t7ghng17 31 43 12 12 CD cord-269652-t7ghng17 31 44 and and CC cord-269652-t7ghng17 31 45 even even RB cord-269652-t7ghng17 31 46 the the DT cord-269652-t7ghng17 31 47 risk risk NN cord-269652-t7ghng17 31 48 of of IN cord-269652-t7ghng17 31 49 LOS LOS NNP cord-269652-t7ghng17 31 50 . . . cord-269652-t7ghng17 32 1 11 11 CD cord-269652-t7ghng17 33 1 The the DT cord-269652-t7ghng17 33 2 purpose purpose NN cord-269652-t7ghng17 33 3 of of IN cord-269652-t7ghng17 33 4 this this DT cord-269652-t7ghng17 33 5 article article NN cord-269652-t7ghng17 33 6 is be VBZ cord-269652-t7ghng17 33 7 to to TO cord-269652-t7ghng17 33 8 provide provide VB cord-269652-t7ghng17 33 9 evidence evidence NN cord-269652-t7ghng17 33 10 - - HYPH cord-269652-t7ghng17 33 11 based base VBN cord-269652-t7ghng17 33 12 practical practical JJ cord-269652-t7ghng17 33 13 approaches approach NNS cord-269652-t7ghng17 33 14 to to IN cord-269652-t7ghng17 33 15 the the DT cord-269652-t7ghng17 33 16 diagnosis diagnosis NN cord-269652-t7ghng17 33 17 , , , cord-269652-t7ghng17 33 18 management management NN cord-269652-t7ghng17 33 19 , , , cord-269652-t7ghng17 33 20 and and CC cord-269652-t7ghng17 33 21 prevention prevention NN cord-269652-t7ghng17 33 22 of of IN cord-269652-t7ghng17 33 23 neonatal neonatal JJ cord-269652-t7ghng17 33 24 infections infection NNS cord-269652-t7ghng17 33 25 . . . cord-269652-t7ghng17 34 1 The the DT cord-269652-t7ghng17 34 2 timing timing NN cord-269652-t7ghng17 34 3 of of IN cord-269652-t7ghng17 34 4 transmission transmission NN cord-269652-t7ghng17 34 5 is be VBZ cord-269652-t7ghng17 34 6 one one CD cord-269652-t7ghng17 34 7 of of IN cord-269652-t7ghng17 34 8 the the DT cord-269652-t7ghng17 34 9 factors factor NNS cord-269652-t7ghng17 34 10 contributing contribute VBG cord-269652-t7ghng17 34 11 to to IN cord-269652-t7ghng17 34 12 the the DT cord-269652-t7ghng17 34 13 cause cause NN cord-269652-t7ghng17 34 14 of of IN cord-269652-t7ghng17 34 15 neonatal neonatal JJ cord-269652-t7ghng17 34 16 infections infection NNS cord-269652-t7ghng17 34 17 . . . cord-269652-t7ghng17 35 1 Different different JJ cord-269652-t7ghng17 35 2 pathogens pathogen NNS cord-269652-t7ghng17 35 3 may may MD cord-269652-t7ghng17 35 4 be be VB cord-269652-t7ghng17 35 5 acquired acquire VBN cord-269652-t7ghng17 35 6 during during IN cord-269652-t7ghng17 35 7 pregnancy pregnancy NN cord-269652-t7ghng17 35 8 ( ( -LRB- cord-269652-t7ghng17 35 9 prenatal prenatal NNP cord-269652-t7ghng17 35 10 ) ) -RRB- cord-269652-t7ghng17 35 11 , , , cord-269652-t7ghng17 35 12 during during IN cord-269652-t7ghng17 35 13 delivery delivery NN cord-269652-t7ghng17 35 14 ( ( -LRB- cord-269652-t7ghng17 35 15 perinatal perinatal NNP cord-269652-t7ghng17 35 16 ) ) -RRB- cord-269652-t7ghng17 35 17 , , , cord-269652-t7ghng17 35 18 or or CC cord-269652-t7ghng17 35 19 after after IN cord-269652-t7ghng17 35 20 delivery delivery NN cord-269652-t7ghng17 35 21 ( ( -LRB- cord-269652-t7ghng17 35 22 postnatal postnatal NN cord-269652-t7ghng17 35 23 ) ) -RRB- cord-269652-t7ghng17 35 24 . . . cord-269652-t7ghng17 36 1 Table table NN cord-269652-t7ghng17 36 2 1 1 CD cord-269652-t7ghng17 36 3 shows show VBZ cord-269652-t7ghng17 36 4 the the DT cord-269652-t7ghng17 36 5 different different JJ cord-269652-t7ghng17 36 6 periods period NNS cord-269652-t7ghng17 36 7 of of IN cord-269652-t7ghng17 36 8 transmission transmission NN cord-269652-t7ghng17 36 9 of of IN cord-269652-t7ghng17 36 10 various various JJ cord-269652-t7ghng17 36 11 neonatal neonatal JJ cord-269652-t7ghng17 36 12 pathogens pathogen NNS cord-269652-t7ghng17 36 13 . . . cord-269652-t7ghng17 37 1 The the DT cord-269652-t7ghng17 37 2 introduction introduction NN cord-269652-t7ghng17 37 3 of of IN cord-269652-t7ghng17 37 4 new new JJ cord-269652-t7ghng17 37 5 molecular molecular NN cord-269652-t7ghng17 37 6 - - HYPH cord-269652-t7ghng17 37 7 based base VBN cord-269652-t7ghng17 37 8 assays assay NNS cord-269652-t7ghng17 37 9 , , , cord-269652-t7ghng17 37 10 such such JJ cord-269652-t7ghng17 37 11 as as IN cord-269652-t7ghng17 37 12 quantitative quantitative JJ cord-269652-t7ghng17 37 13 real real JJ cord-269652-t7ghng17 37 14 - - HYPH cord-269652-t7ghng17 37 15 time time NN cord-269652-t7ghng17 37 16 polymerase polymerase NN cord-269652-t7ghng17 37 17 chain chain NN cord-269652-t7ghng17 37 18 reaction reaction NN cord-269652-t7ghng17 37 19 ( ( -LRB- cord-269652-t7ghng17 37 20 PCR PCR NNP cord-269652-t7ghng17 37 21 ) ) -RRB- cord-269652-t7ghng17 37 22 , , , cord-269652-t7ghng17 37 23 13 13 CD cord-269652-t7ghng17 37 24 has have VBZ cord-269652-t7ghng17 37 25 paved pave VBN cord-269652-t7ghng17 37 26 the the DT cord-269652-t7ghng17 37 27 way way NN cord-269652-t7ghng17 37 28 for for IN cord-269652-t7ghng17 37 29 increasing increase VBG cord-269652-t7ghng17 37 30 recognition recognition NN cord-269652-t7ghng17 37 31 of of IN cord-269652-t7ghng17 37 32 respiratory respiratory JJ cord-269652-t7ghng17 37 33 viral viral JJ cord-269652-t7ghng17 37 34 infections infection NNS cord-269652-t7ghng17 37 35 contributing contribute VBG cord-269652-t7ghng17 37 36 to to IN cord-269652-t7ghng17 37 37 ruling rule VBG cord-269652-t7ghng17 37 38 out out RP cord-269652-t7ghng17 37 39 sepsis sepsis NN cord-269652-t7ghng17 37 40 in in IN cord-269652-t7ghng17 37 41 late late JJ cord-269652-t7ghng17 37 42 - - HYPH cord-269652-t7ghng17 37 43 onset onset NN cord-269652-t7ghng17 37 44 infections infection NNS cord-269652-t7ghng17 37 45 . . . cord-269652-t7ghng17 38 1 14 14 CD cord-269652-t7ghng17 38 2 Table table NN cord-269652-t7ghng17 38 3 1 1 CD cord-269652-t7ghng17 38 4 includes include VBZ cord-269652-t7ghng17 38 5 respiratory respiratory JJ cord-269652-t7ghng17 38 6 viral viral JJ cord-269652-t7ghng17 38 7 infections infection NNS cord-269652-t7ghng17 38 8 ( ( -LRB- cord-269652-t7ghng17 38 9 coronavirus coronavirus NN cord-269652-t7ghng17 38 10 , , , cord-269652-t7ghng17 38 11 enterovirus enterovirus NN cord-269652-t7ghng17 38 12 , , , cord-269652-t7ghng17 38 13 human human JJ cord-269652-t7ghng17 38 14 metapneumovirus metapneumovirus NNP cord-269652-t7ghng17 38 15 , , , cord-269652-t7ghng17 38 16 influenza influenza NN cord-269652-t7ghng17 38 17 , , , cord-269652-t7ghng17 38 18 parainfluenza parainfluenza NNP cord-269652-t7ghng17 38 19 virus virus NN cord-269652-t7ghng17 38 20 , , , cord-269652-t7ghng17 38 21 respiratory respiratory JJ cord-269652-t7ghng17 38 22 syncytial syncytial JJ cord-269652-t7ghng17 38 23 virus virus NN cord-269652-t7ghng17 38 24 [ [ -LRB- cord-269652-t7ghng17 38 25 RSV RSV NNP cord-269652-t7ghng17 38 26 ] ] -RRB- cord-269652-t7ghng17 38 27 , , , cord-269652-t7ghng17 38 28 and and CC cord-269652-t7ghng17 38 29 rhinovirus rhinovirus NN cord-269652-t7ghng17 38 30 ) ) -RRB- cord-269652-t7ghng17 38 31 as as IN cord-269652-t7ghng17 38 32 possible possible JJ cord-269652-t7ghng17 38 33 causes cause NNS cord-269652-t7ghng17 38 34 of of IN cord-269652-t7ghng17 38 35 postnatal postnatal JJ cord-269652-t7ghng17 38 36 infections infection NNS cord-269652-t7ghng17 38 37 in in IN cord-269652-t7ghng17 38 38 infants infant NNS cord-269652-t7ghng17 38 39 . . . cord-269652-t7ghng17 39 1 [ [ -LRB- cord-269652-t7ghng17 39 2 14 14 CD cord-269652-t7ghng17 39 3 ] ] -RRB- cord-269652-t7ghng17 39 4 [ [ -LRB- cord-269652-t7ghng17 39 5 15 15 CD cord-269652-t7ghng17 39 6 ] ] -RRB- cord-269652-t7ghng17 39 7 [ [ -LRB- cord-269652-t7ghng17 39 8 16 16 CD cord-269652-t7ghng17 39 9 ] ] -RRB- cord-269652-t7ghng17 40 1 CLINICAL clinical JJ cord-269652-t7ghng17 40 2 PRESENTATIONS presentation NNS cord-269652-t7ghng17 41 1 Early early JJ cord-269652-t7ghng17 41 2 - - HYPH cord-269652-t7ghng17 41 3 Onset Onset NNP cord-269652-t7ghng17 41 4 Infections Infections NNPS cord-269652-t7ghng17 41 5 EOS EOS NNP cord-269652-t7ghng17 41 6 is be VBZ cord-269652-t7ghng17 41 7 arbitrarily arbitrarily RB cord-269652-t7ghng17 41 8 defined define VBN cord-269652-t7ghng17 41 9 as as IN cord-269652-t7ghng17 41 10 infection infection NN cord-269652-t7ghng17 41 11 within within IN cord-269652-t7ghng17 41 12 the the DT cord-269652-t7ghng17 41 13 first first JJ cord-269652-t7ghng17 41 14 3 3 CD cord-269652-t7ghng17 41 15 days day NNS cord-269652-t7ghng17 41 16 of of IN cord-269652-t7ghng17 41 17 life life NN cord-269652-t7ghng17 41 18 . . . cord-269652-t7ghng17 42 1 The the DT cord-269652-t7ghng17 42 2 most most RBS cord-269652-t7ghng17 42 3 common common JJ cord-269652-t7ghng17 42 4 organisms organism NNS cord-269652-t7ghng17 42 5 associated associate VBN cord-269652-t7ghng17 42 6 with with IN cord-269652-t7ghng17 42 7 EOS EOS NNP cord-269652-t7ghng17 42 8 include include VBP cord-269652-t7ghng17 42 9 GBS GBS NNP cord-269652-t7ghng17 42 10 and and CC cord-269652-t7ghng17 42 11 E e NN cord-269652-t7ghng17 42 12 coli coli NNS cord-269652-t7ghng17 42 13 . . . cord-269652-t7ghng17 43 1 1 1 CD cord-269652-t7ghng17 43 2 , , , cord-269652-t7ghng17 43 3 19 19 CD cord-269652-t7ghng17 44 1 In in IN cord-269652-t7ghng17 44 2 general general JJ cord-269652-t7ghng17 44 3 , , , cord-269652-t7ghng17 44 4 the the DT cord-269652-t7ghng17 44 5 risk risk NN cord-269652-t7ghng17 44 6 of of IN cord-269652-t7ghng17 44 7 bacterial bacterial JJ cord-269652-t7ghng17 44 8 infection infection NN cord-269652-t7ghng17 44 9 in in IN cord-269652-t7ghng17 44 10 a a DT cord-269652-t7ghng17 44 11 healthy healthy RB cord-269652-t7ghng17 44 12 - - HYPH cord-269652-t7ghng17 44 13 appearing appear VBG cord-269652-t7ghng17 44 14 newborn newborn NN cord-269652-t7ghng17 44 15 remains remain VBZ cord-269652-t7ghng17 44 16 relatively relatively RB cord-269652-t7ghng17 44 17 low low JJ cord-269652-t7ghng17 44 18 . . . cord-269652-t7ghng17 45 1 20 20 CD cord-269652-t7ghng17 46 1 The the DT cord-269652-t7ghng17 46 2 most most RBS cord-269652-t7ghng17 46 3 common common JJ cord-269652-t7ghng17 46 4 clinical clinical JJ cord-269652-t7ghng17 46 5 findings finding NNS cord-269652-t7ghng17 46 6 include include VBP cord-269652-t7ghng17 46 7 hypoglycemia hypoglycemia NN cord-269652-t7ghng17 46 8 ( ( -LRB- cord-269652-t7ghng17 46 9 < < XX cord-269652-t7ghng17 46 10 40 40 CD cord-269652-t7ghng17 46 11 mg mg NNP cord-269652-t7ghng17 46 12 / / SYM cord-269652-t7ghng17 46 13 dL dl NN cord-269652-t7ghng17 46 14 , , , cord-269652-t7ghng17 46 15 22 22 CD cord-269652-t7ghng17 46 16 % % NN cord-269652-t7ghng17 46 17 ) ) -RRB- cord-269652-t7ghng17 46 18 and and CC cord-269652-t7ghng17 46 19 hypothermia hypothermia NN cord-269652-t7ghng17 46 20 ( ( -LRB- cord-269652-t7ghng17 46 21 < < NNP cord-269652-t7ghng17 46 22 36.5 36.5 CD cord-269652-t7ghng17 46 23 C C NNP cord-269652-t7ghng17 46 24 , , , cord-269652-t7ghng17 46 25 20 20 CD cord-269652-t7ghng17 46 26 % % NN cord-269652-t7ghng17 46 27 ) ) -RRB- cord-269652-t7ghng17 46 28 , , , cord-269652-t7ghng17 46 29 followed follow VBN cord-269652-t7ghng17 46 30 by by IN cord-269652-t7ghng17 46 31 hyperglycemia hyperglycemia NN cord-269652-t7ghng17 46 32 ( ( -LRB- cord-269652-t7ghng17 46 33 > > NFP cord-269652-t7ghng17 46 34 140 140 CD cord-269652-t7ghng17 46 35 mg mg NNP cord-269652-t7ghng17 46 36 / / SYM cord-269652-t7ghng17 46 37 dL dl NN cord-269652-t7ghng17 46 38 , , , cord-269652-t7ghng17 46 39 19 19 CD cord-269652-t7ghng17 46 40 % % NN cord-269652-t7ghng17 46 41 ) ) -RRB- cord-269652-t7ghng17 46 42 and and CC cord-269652-t7ghng17 46 43 apnea apnea NN cord-269652-t7ghng17 46 44 ( ( -LRB- cord-269652-t7ghng17 46 45 18 18 CD cord-269652-t7ghng17 46 46 % % NN cord-269652-t7ghng17 46 47 ) ) -RRB- cord-269652-t7ghng17 46 48 . . . cord-269652-t7ghng17 47 1 19 19 CD cord-269652-t7ghng17 47 2 Edwards Edwards NNP cord-269652-t7ghng17 47 3 and and CC cord-269652-t7ghng17 47 4 Baker Baker NNP cord-269652-t7ghng17 47 5 21 21 CD cord-269652-t7ghng17 47 6 summarized summarize VBD cord-269652-t7ghng17 47 7 that that IN cord-269652-t7ghng17 47 8 newborn newborn JJ cord-269652-t7ghng17 47 9 infants infant NNS cord-269652-t7ghng17 47 10 with with IN cord-269652-t7ghng17 47 11 sepsis sepsis NN cord-269652-t7ghng17 47 12 manifest manifest VBP cord-269652-t7ghng17 47 13 similar similar JJ cord-269652-t7ghng17 47 14 clinical clinical JJ cord-269652-t7ghng17 47 15 signs sign NNS cord-269652-t7ghng17 47 16 as as IN cord-269652-t7ghng17 47 17 those those DT cord-269652-t7ghng17 47 18 with with IN cord-269652-t7ghng17 47 19 meningitis meningitis NN cord-269652-t7ghng17 47 20 , , , cord-269652-t7ghng17 47 21 including include VBG cord-269652-t7ghng17 47 22 hyperthermia hyperthermia NN cord-269652-t7ghng17 47 23 ; ; : cord-269652-t7ghng17 47 24 hypothermia hypothermia NN cord-269652-t7ghng17 47 25 ; ; , cord-269652-t7ghng17 47 26 respiratory respiratory JJ cord-269652-t7ghng17 47 27 distress distress NN cord-269652-t7ghng17 47 28 ; ; : cord-269652-t7ghng17 47 29 anorexia anorexia NN cord-269652-t7ghng17 47 30 or or CC cord-269652-t7ghng17 47 31 vomiting vomiting NN cord-269652-t7ghng17 47 32 ; ; : cord-269652-t7ghng17 47 33 jaundice jaundice NN cord-269652-t7ghng17 47 34 ; ; : cord-269652-t7ghng17 47 35 and and CC cord-269652-t7ghng17 47 36 lethargy lethargy NN cord-269652-t7ghng17 47 37 . . . cord-269652-t7ghng17 48 1 Hypotension hypotension NN cord-269652-t7ghng17 48 2 may may MD cord-269652-t7ghng17 48 3 be be VB cord-269652-t7ghng17 48 4 more more RBR cord-269652-t7ghng17 48 5 frequently frequently RB cord-269652-t7ghng17 48 6 found find VBN cord-269652-t7ghng17 48 7 in in IN cord-269652-t7ghng17 48 8 infants infant NNS cord-269652-t7ghng17 48 9 with with IN cord-269652-t7ghng17 48 10 sepsis sepsis NN cord-269652-t7ghng17 48 11 , , , cord-269652-t7ghng17 48 12 whereas whereas IN cord-269652-t7ghng17 48 13 irritability irritability NN cord-269652-t7ghng17 48 14 , , , cord-269652-t7ghng17 48 15 convulsions convulsion NNS cord-269652-t7ghng17 48 16 , , , cord-269652-t7ghng17 48 17 and and CC cord-269652-t7ghng17 48 18 bulging bulge VBG cord-269652-t7ghng17 48 19 or or CC cord-269652-t7ghng17 48 20 full full JJ cord-269652-t7ghng17 48 21 fontanel fontanel NN cord-269652-t7ghng17 48 22 is be VBZ cord-269652-t7ghng17 48 23 found find VBN cord-269652-t7ghng17 48 24 in in IN cord-269652-t7ghng17 48 25 those those DT cord-269652-t7ghng17 48 26 with with IN cord-269652-t7ghng17 48 27 meningitis meningitis NN cord-269652-t7ghng17 48 28 . . . cord-269652-t7ghng17 49 1 However however RB cord-269652-t7ghng17 49 2 , , , cord-269652-t7ghng17 49 3 they -PRON- PRP cord-269652-t7ghng17 49 4 cautioned caution VBD cord-269652-t7ghng17 49 5 that that IN cord-269652-t7ghng17 49 6 absence absence NN cord-269652-t7ghng17 49 7 of of IN cord-269652-t7ghng17 49 8 any any DT cord-269652-t7ghng17 49 9 of of IN cord-269652-t7ghng17 49 10 the the DT cord-269652-t7ghng17 49 11 aforementioned aforementioned JJ cord-269652-t7ghng17 49 12 signs sign NNS cord-269652-t7ghng17 49 13 do do VBP cord-269652-t7ghng17 49 14 not not RB cord-269652-t7ghng17 49 15 exclude exclude VB cord-269652-t7ghng17 49 16 central central JJ cord-269652-t7ghng17 49 17 nervous nervous JJ cord-269652-t7ghng17 49 18 system system NN cord-269652-t7ghng17 49 19 involvement involvement NN cord-269652-t7ghng17 49 20 . . . cord-269652-t7ghng17 50 1 Furthermore furthermore RB cord-269652-t7ghng17 50 2 , , , cord-269652-t7ghng17 50 3 it -PRON- PRP cord-269652-t7ghng17 50 4 was be VBD cord-269652-t7ghng17 50 5 suggested suggest VBN cord-269652-t7ghng17 50 6 to to TO cord-269652-t7ghng17 50 7 evaluate evaluate VB cord-269652-t7ghng17 50 8 infants infant NNS cord-269652-t7ghng17 50 9 for for IN cord-269652-t7ghng17 50 10 various various JJ cord-269652-t7ghng17 50 11 foci foci NN cord-269652-t7ghng17 50 12 of of IN cord-269652-t7ghng17 50 13 infections infection NNS cord-269652-t7ghng17 50 14 such such JJ cord-269652-t7ghng17 50 15 as as IN cord-269652-t7ghng17 50 16 acute acute JJ cord-269652-t7ghng17 50 17 otitis otitis NN cord-269652-t7ghng17 50 18 media medium NNS cord-269652-t7ghng17 50 19 , , , cord-269652-t7ghng17 50 20 conjunctivitis conjunctivitis NN cord-269652-t7ghng17 50 21 , , , cord-269652-t7ghng17 50 22 osteomyelitis osteomyelitis NN cord-269652-t7ghng17 50 23 , , , cord-269652-t7ghng17 50 24 pyogenic pyogenic JJ cord-269652-t7ghng17 50 25 arthritis arthritis NN cord-269652-t7ghng17 50 26 , , , cord-269652-t7ghng17 50 27 and and CC cord-269652-t7ghng17 50 28 skin skin VB cord-269652-t7ghng17 50 29 soft soft JJ cord-269652-t7ghng17 50 30 - - HYPH cord-269652-t7ghng17 50 31 tissue tissue NN cord-269652-t7ghng17 50 32 infections infection NNS cord-269652-t7ghng17 50 33 . . . cord-269652-t7ghng17 51 1 LOS LOS NNP cord-269652-t7ghng17 51 2 is be VBZ cord-269652-t7ghng17 51 3 arbitrarily arbitrarily RB cord-269652-t7ghng17 51 4 defined define VBN cord-269652-t7ghng17 51 5 as as IN cord-269652-t7ghng17 51 6 infection infection NN cord-269652-t7ghng17 51 7 after after IN cord-269652-t7ghng17 51 8 3 3 CD cord-269652-t7ghng17 51 9 days day NNS cord-269652-t7ghng17 51 10 of of IN cord-269652-t7ghng17 51 11 life life NN cord-269652-t7ghng17 51 12 . . . cord-269652-t7ghng17 52 1 The the DT cord-269652-t7ghng17 52 2 most most RBS cord-269652-t7ghng17 52 3 common common JJ cord-269652-t7ghng17 52 4 organisms organism NNS cord-269652-t7ghng17 52 5 isolated isolate VBN cord-269652-t7ghng17 52 6 with with IN cord-269652-t7ghng17 52 7 LOS LOS NNP cord-269652-t7ghng17 52 8 include include VBP cord-269652-t7ghng17 52 9 coagulase coagulase NN cord-269652-t7ghng17 52 10 - - HYPH cord-269652-t7ghng17 52 11 negative negative JJ cord-269652-t7ghng17 52 12 staphylococci staphylococcus NNS cord-269652-t7ghng17 52 13 in in IN cord-269652-t7ghng17 52 14 more more JJR cord-269652-t7ghng17 52 15 than than IN cord-269652-t7ghng17 52 16 a a DT cord-269652-t7ghng17 52 17 third third NN cord-269652-t7ghng17 52 18 of of IN cord-269652-t7ghng17 52 19 the the DT cord-269652-t7ghng17 52 20 cases case NNS cord-269652-t7ghng17 52 21 , , , cord-269652-t7ghng17 52 22 which which WDT cord-269652-t7ghng17 52 23 may may MD cord-269652-t7ghng17 52 24 or or CC cord-269652-t7ghng17 52 25 may may MD cord-269652-t7ghng17 52 26 not not RB cord-269652-t7ghng17 52 27 be be VB cord-269652-t7ghng17 52 28 associated associate VBN cord-269652-t7ghng17 52 29 with with IN cord-269652-t7ghng17 52 30 a a DT cord-269652-t7ghng17 52 31 medical medical JJ cord-269652-t7ghng17 52 32 device device NN cord-269652-t7ghng17 52 33 . . . cord-269652-t7ghng17 53 1 19 19 CD cord-269652-t7ghng17 53 2 Yeast Yeast NNP cord-269652-t7ghng17 53 3 or or CC cord-269652-t7ghng17 53 4 Candida Candida NNP cord-269652-t7ghng17 53 5 spp spp NNS cord-269652-t7ghng17 53 6 infection infection NN cord-269652-t7ghng17 53 7 is be VBZ cord-269652-t7ghng17 53 8 another another DT cord-269652-t7ghng17 53 9 important important JJ cord-269652-t7ghng17 53 10 pathogen pathogen NN cord-269652-t7ghng17 53 11 . . . cord-269652-t7ghng17 54 1 19 19 CD cord-269652-t7ghng17 55 1 Also also RB cord-269652-t7ghng17 55 2 , , , cord-269652-t7ghng17 55 3 there there EX cord-269652-t7ghng17 55 4 is be VBZ cord-269652-t7ghng17 55 5 increasing increase VBG cord-269652-t7ghng17 55 6 recognition recognition NN cord-269652-t7ghng17 55 7 of of IN cord-269652-t7ghng17 55 8 viral viral JJ cord-269652-t7ghng17 55 9 respiratory respiratory JJ cord-269652-t7ghng17 55 10 infections infection NNS cord-269652-t7ghng17 55 11 as as IN cord-269652-t7ghng17 55 12 a a DT cord-269652-t7ghng17 55 13 possible possible JJ cord-269652-t7ghng17 55 14 cause cause NN cord-269652-t7ghng17 55 15 in in IN cord-269652-t7ghng17 55 16 LOS LOS NNP cord-269652-t7ghng17 55 17 . . . cord-269652-t7ghng17 56 1 14 14 CD cord-269652-t7ghng17 57 1 The the DT cord-269652-t7ghng17 57 2 most most RBS cord-269652-t7ghng17 57 3 common common JJ cord-269652-t7ghng17 57 4 clinical clinical JJ cord-269652-t7ghng17 57 5 findings finding NNS cord-269652-t7ghng17 57 6 include include VBP cord-269652-t7ghng17 57 7 hypothermia hypothermia NN cord-269652-t7ghng17 57 8 ( ( -LRB- cord-269652-t7ghng17 57 9 41 41 CD cord-269652-t7ghng17 57 10 % % NN cord-269652-t7ghng17 57 11 ) ) -RRB- cord-269652-t7ghng17 57 12 , , , cord-269652-t7ghng17 57 13 hyperglycemia hyperglycemia NN cord-269652-t7ghng17 57 14 ( ( -LRB- cord-269652-t7ghng17 57 15 38 38 CD cord-269652-t7ghng17 57 16 % % NN cord-269652-t7ghng17 57 17 ) ) -RRB- cord-269652-t7ghng17 57 18 , , , cord-269652-t7ghng17 57 19 apnea apnea NN cord-269652-t7ghng17 57 20 ( ( -LRB- cord-269652-t7ghng17 57 21 38 38 CD cord-269652-t7ghng17 57 22 % % NN cord-269652-t7ghng17 57 23 ) ) -RRB- cord-269652-t7ghng17 57 24 , , , cord-269652-t7ghng17 57 25 and and CC cord-269652-t7ghng17 57 26 bradycardia bradycardia JJ cord-269652-t7ghng17 57 27 ( ( -LRB- cord-269652-t7ghng17 57 28 30 30 CD cord-269652-t7ghng17 57 29 % % NN cord-269652-t7ghng17 57 30 ) ) -RRB- cord-269652-t7ghng17 57 31 . . . cord-269652-t7ghng17 58 1 19 19 CD cord-269652-t7ghng17 58 2 There there EX cord-269652-t7ghng17 58 3 are be VBP cord-269652-t7ghng17 58 4 several several JJ cord-269652-t7ghng17 58 5 factors factor NNS cord-269652-t7ghng17 58 6 that that WDT cord-269652-t7ghng17 58 7 may may MD cord-269652-t7ghng17 58 8 increase increase VB cord-269652-t7ghng17 58 9 the the DT cord-269652-t7ghng17 58 10 risk risk NN cord-269652-t7ghng17 58 11 for for IN cord-269652-t7ghng17 58 12 LOS LOS NNP cord-269652-t7ghng17 58 13 . . . cord-269652-t7ghng17 59 1 There there EX cord-269652-t7ghng17 59 2 are be VBP cord-269652-t7ghng17 59 3 significantly significantly RB cord-269652-t7ghng17 59 4 more more JJR cord-269652-t7ghng17 59 5 infants infant NNS cord-269652-t7ghng17 59 6 with with IN cord-269652-t7ghng17 59 7 LOS LOS NNP cord-269652-t7ghng17 59 8 who who WP cord-269652-t7ghng17 59 9 have have VBP cord-269652-t7ghng17 59 10 an an DT cord-269652-t7ghng17 59 11 indwelling indwell VBG cord-269652-t7ghng17 59 12 central central JJ cord-269652-t7ghng17 59 13 vascular vascular JJ cord-269652-t7ghng17 59 14 catheter catheter NN cord-269652-t7ghng17 59 15 at at IN cord-269652-t7ghng17 59 16 the the DT cord-269652-t7ghng17 59 17 time time NN cord-269652-t7ghng17 59 18 of of IN cord-269652-t7ghng17 59 19 infection infection NN cord-269652-t7ghng17 59 20 than than IN cord-269652-t7ghng17 59 21 those those DT cord-269652-t7ghng17 59 22 infants infant NNS cord-269652-t7ghng17 59 23 with with IN cord-269652-t7ghng17 59 24 EOS EOS NNP cord-269652-t7ghng17 59 25 ( ( -LRB- cord-269652-t7ghng17 59 26 78 78 CD cord-269652-t7ghng17 59 27 % % NN cord-269652-t7ghng17 59 28 vs vs IN cord-269652-t7ghng17 59 29 10 10 CD cord-269652-t7ghng17 59 30 % % NN cord-269652-t7ghng17 59 31 , , , cord-269652-t7ghng17 59 32 P<.0001 P<.0001 NNP cord-269652-t7ghng17 59 33 ) ) -RRB- cord-269652-t7ghng17 59 34 . . . cord-269652-t7ghng17 60 1 19 19 CD cord-269652-t7ghng17 60 2 Additionally additionally RB cord-269652-t7ghng17 60 3 , , , cord-269652-t7ghng17 60 4 there there EX cord-269652-t7ghng17 60 5 are be VBP cord-269652-t7ghng17 60 6 more more JJR cord-269652-t7ghng17 60 7 infants infant NNS cord-269652-t7ghng17 60 8 with with IN cord-269652-t7ghng17 60 9 LOS LOS NNP cord-269652-t7ghng17 60 10 who who WP cord-269652-t7ghng17 60 11 had have VBD cord-269652-t7ghng17 60 12 a a DT cord-269652-t7ghng17 60 13 surgical surgical JJ cord-269652-t7ghng17 60 14 procedure procedure NN cord-269652-t7ghng17 60 15 before before IN cord-269652-t7ghng17 60 16 infection infection NN cord-269652-t7ghng17 60 17 ( ( -LRB- cord-269652-t7ghng17 60 18 8 8 CD cord-269652-t7ghng17 60 19 % % NN cord-269652-t7ghng17 60 20 vs vs IN cord-269652-t7ghng17 60 21 1 1 CD cord-269652-t7ghng17 60 22 % % NN cord-269652-t7ghng17 60 23 , , , cord-269652-t7ghng17 60 24 P<.0001 P<.0001 NNP cord-269652-t7ghng17 60 25 ) ) -RRB- cord-269652-t7ghng17 60 26 . . . cord-269652-t7ghng17 61 1 The the DT cord-269652-t7ghng17 61 2 clinical clinical JJ cord-269652-t7ghng17 61 3 presentations presentation NNS cord-269652-t7ghng17 61 4 of of IN cord-269652-t7ghng17 61 5 infections infection NNS cord-269652-t7ghng17 61 6 may may MD cord-269652-t7ghng17 61 7 overlap overlap VB cord-269652-t7ghng17 61 8 with with IN cord-269652-t7ghng17 61 9 noninfectious noninfectious JJ cord-269652-t7ghng17 61 10 causes cause NNS cord-269652-t7ghng17 61 11 in in IN cord-269652-t7ghng17 61 12 newborns newborn NNS cord-269652-t7ghng17 61 13 . . . cord-269652-t7ghng17 62 1 It -PRON- PRP cord-269652-t7ghng17 62 2 has have VBZ cord-269652-t7ghng17 62 3 been be VBN cord-269652-t7ghng17 62 4 previously previously RB cord-269652-t7ghng17 62 5 demonstrated demonstrate VBN cord-269652-t7ghng17 62 6 that that IN cord-269652-t7ghng17 62 7 relying rely VBG cord-269652-t7ghng17 62 8 on on IN cord-269652-t7ghng17 62 9 symptoms symptom NNS cord-269652-t7ghng17 62 10 alone alone RB cord-269652-t7ghng17 62 11 may may MD cord-269652-t7ghng17 62 12 not not RB cord-269652-t7ghng17 62 13 be be VB cord-269652-t7ghng17 62 14 sufficient sufficient JJ cord-269652-t7ghng17 62 15 in in IN cord-269652-t7ghng17 62 16 diagnosing diagnose VBG cord-269652-t7ghng17 62 17 neonatal neonatal JJ cord-269652-t7ghng17 62 18 infections infection NNS cord-269652-t7ghng17 62 19 . . . cord-269652-t7ghng17 63 1 22 22 CD cord-269652-t7ghng17 63 2 Bacteremia Bacteremia NNP cord-269652-t7ghng17 63 3 has have VBZ cord-269652-t7ghng17 63 4 been be VBN cord-269652-t7ghng17 63 5 reported report VBN cord-269652-t7ghng17 63 6 in in IN cord-269652-t7ghng17 63 7 infants infant NNS cord-269652-t7ghng17 63 8 without without IN cord-269652-t7ghng17 63 9 clinical clinical JJ cord-269652-t7ghng17 63 10 signs sign NNS cord-269652-t7ghng17 63 11 of of IN cord-269652-t7ghng17 63 12 sepsis sepsis NN cord-269652-t7ghng17 63 13 . . . cord-269652-t7ghng17 64 1 23 23 LS cord-269652-t7ghng17 64 2 There there EX cord-269652-t7ghng17 64 3 are be VBP cord-269652-t7ghng17 64 4 several several JJ cord-269652-t7ghng17 64 5 diagnostic diagnostic JJ cord-269652-t7ghng17 64 6 tests test NNS cord-269652-t7ghng17 64 7 and and CC cord-269652-t7ghng17 64 8 principles principle NNS cord-269652-t7ghng17 64 9 that that WDT cord-269652-t7ghng17 64 10 may may MD cord-269652-t7ghng17 64 11 guide guide VB cord-269652-t7ghng17 64 12 clinicians clinician NNS cord-269652-t7ghng17 64 13 in in IN cord-269652-t7ghng17 64 14 evaluating evaluate VBG cord-269652-t7ghng17 64 15 infants infant NNS cord-269652-t7ghng17 64 16 with with IN cord-269652-t7ghng17 64 17 infections infection NNS cord-269652-t7ghng17 64 18 . . . cord-269652-t7ghng17 65 1 The the DT cord-269652-t7ghng17 65 2 AAP AAP NNP cord-269652-t7ghng17 65 3 Committee Committee NNP cord-269652-t7ghng17 65 4 on on IN cord-269652-t7ghng17 65 5 Fetus Fetus NNP cord-269652-t7ghng17 65 6 and and CC cord-269652-t7ghng17 65 7 Newborn Newborn NNP cord-269652-t7ghng17 65 8 have have VBP cord-269652-t7ghng17 65 9 published publish VBN cord-269652-t7ghng17 65 10 a a DT cord-269652-t7ghng17 65 11 clinical clinical JJ cord-269652-t7ghng17 65 12 report report NN cord-269652-t7ghng17 65 13 on on IN cord-269652-t7ghng17 65 14 the the DT cord-269652-t7ghng17 65 15 evaluation evaluation NN cord-269652-t7ghng17 65 16 of of IN cord-269652-t7ghng17 65 17 asymptomatic asymptomatic JJ cord-269652-t7ghng17 65 18 infants infant NNS cord-269652-t7ghng17 65 19 ( ( -LRB- cord-269652-t7ghng17 65 20 < < NNP cord-269652-t7ghng17 65 21 37 37 CD cord-269652-t7ghng17 65 22 and and CC cord-269652-t7ghng17 65 23 ! ! . cord-269652-t7ghng17 66 1 37 37 CD cord-269652-t7ghng17 66 2 week week NN cord-269652-t7ghng17 66 3 gestation gestation NN cord-269652-t7ghng17 66 4 ) ) -RRB- cord-269652-t7ghng17 66 5 with with IN cord-269652-t7ghng17 66 6 risk risk NN cord-269652-t7ghng17 66 7 factors factor NNS cord-269652-t7ghng17 66 8 for for IN cord-269652-t7ghng17 66 9 sepsis sepsis NN cord-269652-t7ghng17 66 10 . . . cord-269652-t7ghng17 67 1 7 7 CD cord-269652-t7ghng17 67 2 Evaluation evaluation NN cord-269652-t7ghng17 67 3 of of IN cord-269652-t7ghng17 67 4 asymptomatic asymptomatic JJ cord-269652-t7ghng17 67 5 preterm preterm JJ cord-269652-t7ghng17 67 6 infants infant NNS cord-269652-t7ghng17 67 7 ( ( -LRB- cord-269652-t7ghng17 67 8 < < XX cord-269652-t7ghng17 67 9 37-week 37-week CD cord-269652-t7ghng17 67 10 ) ) -RRB- cord-269652-t7ghng17 67 11 with with IN cord-269652-t7ghng17 67 12 risk risk NN cord-269652-t7ghng17 67 13 factors factor NNS cord-269652-t7ghng17 67 14 for for IN cord-269652-t7ghng17 67 15 sepsis sepsis NN cord-269652-t7ghng17 67 16 is be VBZ cord-269652-t7ghng17 67 17 shown show VBN cord-269652-t7ghng17 67 18 in in IN cord-269652-t7ghng17 67 19 Fig Fig NNP cord-269652-t7ghng17 67 20 . . . cord-269652-t7ghng17 68 1 1 1 LS cord-269652-t7ghng17 68 2 . . . cord-269652-t7ghng17 69 1 7 7 CD cord-269652-t7ghng17 70 1 Similar similar JJ cord-269652-t7ghng17 70 2 algorithms algorithm NNS cord-269652-t7ghng17 70 3 for for IN cord-269652-t7ghng17 70 4 the the DT cord-269652-t7ghng17 70 5 evaluation evaluation NN cord-269652-t7ghng17 70 6 of of IN cord-269652-t7ghng17 70 7 asymptomatic asymptomatic JJ cord-269652-t7ghng17 70 8 term term NN cord-269652-t7ghng17 70 9 infants infant NNS cord-269652-t7ghng17 70 10 ( ( -LRB- cord-269652-t7ghng17 70 11 ! ! . cord-269652-t7ghng17 70 12 37 37 CD cord-269652-t7ghng17 70 13 week week NN cord-269652-t7ghng17 70 14 gestation gestation NN cord-269652-t7ghng17 70 15 ) ) -RRB- cord-269652-t7ghng17 70 16 are be VBP cord-269652-t7ghng17 70 17 available available JJ cord-269652-t7ghng17 70 18 from from IN cord-269652-t7ghng17 70 19 the the DT cord-269652-t7ghng17 70 20 AAP AAP NNP cord-269652-t7ghng17 70 21 Committee Committee NNP cord-269652-t7ghng17 70 22 on on IN cord-269652-t7ghng17 70 23 Fetus Fetus NNP cord-269652-t7ghng17 70 24 and and CC cord-269652-t7ghng17 70 25 Newborn Newborn NNP cord-269652-t7ghng17 70 26 . . . cord-269652-t7ghng17 71 1 ( ( -LRB- cord-269652-t7ghng17 71 2 http://www.ncbi.nlm.nih.gov/pubmed/22547779 http://www.ncbi.nlm.nih.gov/pubmed/22547779 NN cord-269652-t7ghng17 71 3 ) ) -RRB- cord-269652-t7ghng17 71 4 . . . cord-269652-t7ghng17 72 1 7 7 CD cord-269652-t7ghng17 72 2 Additional additional JJ cord-269652-t7ghng17 72 3 principles principle NNS cord-269652-t7ghng17 72 4 in in IN cord-269652-t7ghng17 72 5 the the DT cord-269652-t7ghng17 72 6 evaluation evaluation NN cord-269652-t7ghng17 72 7 of of IN cord-269652-t7ghng17 72 8 infants infant NNS cord-269652-t7ghng17 72 9 with with IN cord-269652-t7ghng17 72 10 risk risk NN cord-269652-t7ghng17 72 11 factors factor NNS cord-269652-t7ghng17 72 12 for for IN cord-269652-t7ghng17 72 13 sepsis sepsis NN cord-269652-t7ghng17 72 14 7 7 CD cord-269652-t7ghng17 72 15 follow follow NN cord-269652-t7ghng17 72 16 : : : cord-269652-t7ghng17 72 17 Major major JJ cord-269652-t7ghng17 72 18 risk risk NN cord-269652-t7ghng17 72 19 factors factor NNS cord-269652-t7ghng17 72 20 for for IN cord-269652-t7ghng17 72 21 neonatal neonatal JJ cord-269652-t7ghng17 72 22 sepsis sepsis NN cord-269652-t7ghng17 72 23 include include VBP cord-269652-t7ghng17 72 24 chorioamnionitis chorioamnionitis NN cord-269652-t7ghng17 72 25 , , , cord-269652-t7ghng17 72 26 prolonged prolong VBN cord-269652-t7ghng17 72 27 rupture rupture NN cord-269652-t7ghng17 72 28 of of IN cord-269652-t7ghng17 72 29 membrane membrane NN cord-269652-t7ghng17 72 30 18 18 CD cord-269652-t7ghng17 72 31 or or CC cord-269652-t7ghng17 72 32 more more JJR cord-269652-t7ghng17 72 33 hours hour NNS cord-269652-t7ghng17 72 34 , , , cord-269652-t7ghng17 72 35 and and CC cord-269652-t7ghng17 72 36 colonization colonization NN cord-269652-t7ghng17 72 37 of of IN cord-269652-t7ghng17 72 38 GBS GBS NNP cord-269652-t7ghng17 72 39 with with IN cord-269652-t7ghng17 72 40 inadequate inadequate JJ cord-269652-t7ghng17 72 41 intrapartum intrapartum NN cord-269652-t7ghng17 72 42 antimicrobial antimicrobial JJ cord-269652-t7ghng17 72 43 prophylaxis prophylaxis NN cord-269652-t7ghng17 72 44 ( ( -LRB- cord-269652-t7ghng17 72 45 IAP IAP NNP cord-269652-t7ghng17 72 46 ) ) -RRB- cord-269652-t7ghng17 72 47 . . . cord-269652-t7ghng17 73 1 Chorioamnionitis Chorioamnionitis NNP cord-269652-t7ghng17 73 2 usually usually RB cord-269652-t7ghng17 73 3 presents present VBZ cord-269652-t7ghng17 73 4 as as IN cord-269652-t7ghng17 73 5 maternal maternal JJ cord-269652-t7ghng17 73 6 fever fever NN cord-269652-t7ghng17 73 7 greater great JJR cord-269652-t7ghng17 73 8 than than IN cord-269652-t7ghng17 73 9 38 38 CD cord-269652-t7ghng17 73 10 C c NN cord-269652-t7ghng17 73 11 ( ( -LRB- cord-269652-t7ghng17 73 12 100.4 100.4 CD cord-269652-t7ghng17 73 13 F F NNP cord-269652-t7ghng17 73 14 ) ) -RRB- cord-269652-t7ghng17 73 15 and and CC cord-269652-t7ghng17 73 16 its -PRON- PRP$ cord-269652-t7ghng17 73 17 diagnosis diagnosis NN cord-269652-t7ghng17 73 18 should should MD cord-269652-t7ghng17 73 19 be be VB cord-269652-t7ghng17 73 20 discussed discuss VBN cord-269652-t7ghng17 73 21 with with IN cord-269652-t7ghng17 73 22 the the DT cord-269652-t7ghng17 73 23 obstetric obstetric JJ cord-269652-t7ghng17 73 24 providers provider NNS cord-269652-t7ghng17 73 25 . . . cord-269652-t7ghng17 74 1 Maternal maternal JJ cord-269652-t7ghng17 74 2 fever fever NN cord-269652-t7ghng17 74 3 may may MD cord-269652-t7ghng17 74 4 be be VB cord-269652-t7ghng17 74 5 the the DT cord-269652-t7ghng17 74 6 only only JJ cord-269652-t7ghng17 74 7 abnormal abnormal JJ cord-269652-t7ghng17 74 8 finding finding NN cord-269652-t7ghng17 74 9 in in IN cord-269652-t7ghng17 74 10 chorioamnionitis chorioamnionitis NN cord-269652-t7ghng17 74 11 . . . cord-269652-t7ghng17 75 1 Adequate adequate JJ cord-269652-t7ghng17 75 2 IAP IAP NNP cord-269652-t7ghng17 75 3 means mean VBZ cord-269652-t7ghng17 75 4 maternal maternal JJ cord-269652-t7ghng17 75 5 treatment treatment NN cord-269652-t7ghng17 75 6 with with IN cord-269652-t7ghng17 75 7 penicillin penicillin NN cord-269652-t7ghng17 75 8 , , , cord-269652-t7ghng17 75 9 ampicillin ampicillin NN cord-269652-t7ghng17 75 10 , , , cord-269652-t7ghng17 75 11 or or CC cord-269652-t7ghng17 75 12 cefazolin cefazolin NN cord-269652-t7ghng17 75 13 at at IN cord-269652-t7ghng17 75 14 or or CC cord-269652-t7ghng17 75 15 earlier early JJR cord-269652-t7ghng17 75 16 than than IN cord-269652-t7ghng17 75 17 4 4 CD cord-269652-t7ghng17 75 18 hours hour NNS cord-269652-t7ghng17 75 19 before before IN cord-269652-t7ghng17 75 20 delivery delivery NN cord-269652-t7ghng17 75 21 . . . cord-269652-t7ghng17 76 1 At at RB cord-269652-t7ghng17 76 2 least least JJS cord-269652-t7ghng17 76 3 1 1 CD cord-269652-t7ghng17 76 4 mL ml NN cord-269652-t7ghng17 76 5 of of IN cord-269652-t7ghng17 76 6 blood blood NN cord-269652-t7ghng17 76 7 may may MD cord-269652-t7ghng17 76 8 be be VB cord-269652-t7ghng17 76 9 sufficient sufficient JJ cord-269652-t7ghng17 76 10 for for IN cord-269652-t7ghng17 76 11 a a DT cord-269652-t7ghng17 76 12 single single JJ cord-269652-t7ghng17 76 13 blood blood NN cord-269652-t7ghng17 76 14 culture culture NN cord-269652-t7ghng17 76 15 from from IN cord-269652-t7ghng17 76 16 a a DT cord-269652-t7ghng17 76 17 peripheral peripheral JJ cord-269652-t7ghng17 76 18 vein vein NN cord-269652-t7ghng17 76 19 . . . cord-269652-t7ghng17 77 1 Blood blood NN cord-269652-t7ghng17 77 2 culture culture NN cord-269652-t7ghng17 77 3 from from IN cord-269652-t7ghng17 77 4 umbilical umbilical JJ cord-269652-t7ghng17 77 5 artery artery NN cord-269652-t7ghng17 77 6 catheter catheter NN cord-269652-t7ghng17 77 7 or or CC cord-269652-t7ghng17 77 8 umbilical umbilical JJ cord-269652-t7ghng17 77 9 vein vein NN cord-269652-t7ghng17 77 10 may may MD cord-269652-t7ghng17 77 11 be be VB cord-269652-t7ghng17 77 12 a a DT cord-269652-t7ghng17 77 13 reliable reliable JJ cord-269652-t7ghng17 77 14 alternative alternative JJ cord-269652-t7ghng17 77 15 following follow VBG cord-269652-t7ghng17 77 16 aseptic aseptic JJ cord-269652-t7ghng17 77 17 techniques technique NNS cord-269652-t7ghng17 77 18 Screening screen VBG cord-269652-t7ghng17 77 19 blood blood NN cord-269652-t7ghng17 77 20 cultures culture NNS cord-269652-t7ghng17 77 21 have have VBP cord-269652-t7ghng17 77 22 not not RB cord-269652-t7ghng17 77 23 been be VBN cord-269652-t7ghng17 77 24 proven prove VBN cord-269652-t7ghng17 77 25 of of IN cord-269652-t7ghng17 77 26 value value NN cord-269652-t7ghng17 77 27 and and CC cord-269652-t7ghng17 77 28 are be VBP cord-269652-t7ghng17 77 29 not not RB cord-269652-t7ghng17 77 30 recommended recommend VBN cord-269652-t7ghng17 77 31 . . . cord-269652-t7ghng17 78 1 Complete complete JJ cord-269652-t7ghng17 78 2 blood blood NN cord-269652-t7ghng17 78 3 count count NN cord-269652-t7ghng17 78 4 with with IN cord-269652-t7ghng17 78 5 differential differential NN cord-269652-t7ghng17 78 6 has have VBZ cord-269652-t7ghng17 78 7 poor poor JJ cord-269652-t7ghng17 78 8 positive positive JJ cord-269652-t7ghng17 78 9 predictive predictive JJ cord-269652-t7ghng17 78 10 value value NN cord-269652-t7ghng17 78 11 and and CC cord-269652-t7ghng17 78 12 it -PRON- PRP cord-269652-t7ghng17 78 13 is be VBZ cord-269652-t7ghng17 78 14 suggested suggest VBN cord-269652-t7ghng17 78 15 waiting wait VBG cord-269652-t7ghng17 78 16 6 6 CD cord-269652-t7ghng17 78 17 to to TO cord-269652-t7ghng17 78 18 12 12 CD cord-269652-t7ghng17 78 19 hours hour NNS cord-269652-t7ghng17 78 20 after after IN cord-269652-t7ghng17 78 21 birth birth NN cord-269652-t7ghng17 78 22 to to TO cord-269652-t7ghng17 78 23 avoid avoid VB cord-269652-t7ghng17 78 24 falsely falsely RB cord-269652-t7ghng17 78 25 normal normal JJ cord-269652-t7ghng17 78 26 values value NNS cord-269652-t7ghng17 78 27 at at IN cord-269652-t7ghng17 78 28 birth birth NN cord-269652-t7ghng17 78 29 . . . cord-269652-t7ghng17 79 1 Platelet platelet NN cord-269652-t7ghng17 79 2 counts count NNS cord-269652-t7ghng17 79 3 remain remain VBP cord-269652-t7ghng17 79 4 low low JJ cord-269652-t7ghng17 79 5 days day NNS cord-269652-t7ghng17 79 6 to to IN cord-269652-t7ghng17 79 7 weeks week NNS cord-269652-t7ghng17 79 8 after after IN cord-269652-t7ghng17 79 9 sepsis sepsis NN cord-269652-t7ghng17 79 10 ; ; : cord-269652-t7ghng17 79 11 thus thus RB cord-269652-t7ghng17 79 12 this this DT cord-269652-t7ghng17 79 13 can can MD cord-269652-t7ghng17 79 14 not not RB cord-269652-t7ghng17 79 15 be be VB cord-269652-t7ghng17 79 16 used use VBN cord-269652-t7ghng17 79 17 in in IN cord-269652-t7ghng17 79 18 following follow VBG cord-269652-t7ghng17 79 19 response response NN cord-269652-t7ghng17 79 20 to to IN cord-269652-t7ghng17 79 21 treatment treatment NN cord-269652-t7ghng17 79 22 . . . cord-269652-t7ghng17 80 1 The the DT cord-269652-t7ghng17 80 2 sensitivity sensitivity NN cord-269652-t7ghng17 80 3 of of IN cord-269652-t7ghng17 80 4 C c NN cord-269652-t7ghng17 80 5 - - HYPH cord-269652-t7ghng17 80 6 reactive reactive JJ cord-269652-t7ghng17 80 7 protein protein NN cord-269652-t7ghng17 80 8 ( ( -LRB- cord-269652-t7ghng17 80 9 CRP CRP NNP cord-269652-t7ghng17 80 10 ) ) -RRB- cord-269652-t7ghng17 80 11 improves improve VBZ cord-269652-t7ghng17 80 12 if if IN cord-269652-t7ghng17 80 13 done do VBN cord-269652-t7ghng17 80 14 6 6 CD cord-269652-t7ghng17 80 15 to to TO cord-269652-t7ghng17 80 16 12 12 CD cord-269652-t7ghng17 80 17 hours hour NNS cord-269652-t7ghng17 80 18 after after IN cord-269652-t7ghng17 80 19 birth birth NN cord-269652-t7ghng17 80 20 . . . cord-269652-t7ghng17 81 1 Bacterial bacterial JJ cord-269652-t7ghng17 81 2 sepsis sepsis NN cord-269652-t7ghng17 81 3 is be VBZ cord-269652-t7ghng17 81 4 unlikely unlikely JJ cord-269652-t7ghng17 81 5 if if IN cord-269652-t7ghng17 81 6 CRP CRP NNP cord-269652-t7ghng17 81 7 remains remain VBZ cord-269652-t7ghng17 81 8 normal normal JJ cord-269652-t7ghng17 81 9 . . . cord-269652-t7ghng17 82 1 Lumbar lumbar JJ cord-269652-t7ghng17 82 2 puncture puncture NN cord-269652-t7ghng17 82 3 may may MD cord-269652-t7ghng17 82 4 be be VB cord-269652-t7ghng17 82 5 indicated indicate VBN cord-269652-t7ghng17 82 6 in in IN cord-269652-t7ghng17 82 7 infants infant NNS cord-269652-t7ghng17 82 8 whom whom WP cord-269652-t7ghng17 82 9 sepsis sepsis NN cord-269652-t7ghng17 82 10 is be VBZ cord-269652-t7ghng17 82 11 highly highly RB cord-269652-t7ghng17 82 12 suspected suspect VBN cord-269652-t7ghng17 82 13 , , , cord-269652-t7ghng17 82 14 those those DT cord-269652-t7ghng17 82 15 infants infant NNS cord-269652-t7ghng17 82 16 with with IN cord-269652-t7ghng17 82 17 bacteremia bacteremia NN cord-269652-t7ghng17 82 18 , , , cord-269652-t7ghng17 82 19 and and CC cord-269652-t7ghng17 82 20 in in IN cord-269652-t7ghng17 82 21 infants infant NNS cord-269652-t7ghng17 82 22 who who WP cord-269652-t7ghng17 82 23 fail fail VBP cord-269652-t7ghng17 82 24 to to TO cord-269652-t7ghng17 82 25 respond respond VB cord-269652-t7ghng17 82 26 to to IN cord-269652-t7ghng17 82 27 antimicrobial antimicrobial JJ cord-269652-t7ghng17 82 28 therapy therapy NN cord-269652-t7ghng17 82 29 . . . cord-269652-t7ghng17 83 1 Urinary urinary JJ cord-269652-t7ghng17 83 2 tract tract NN cord-269652-t7ghng17 83 3 infection infection NN cord-269652-t7ghng17 83 4 in in IN cord-269652-t7ghng17 83 5 newborns newborn NNS cord-269652-t7ghng17 83 6 is be VBZ cord-269652-t7ghng17 83 7 associated associate VBN cord-269652-t7ghng17 83 8 with with IN cord-269652-t7ghng17 83 9 episodes episode NNS cord-269652-t7ghng17 83 10 of of IN cord-269652-t7ghng17 83 11 bacteremia bacteremia NN cord-269652-t7ghng17 83 12 ; ; : cord-269652-t7ghng17 83 13 thus thus RB cord-269652-t7ghng17 83 14 urine urine NN cord-269652-t7ghng17 83 15 culture culture NN cord-269652-t7ghng17 83 16 should should MD cord-269652-t7ghng17 83 17 not not RB cord-269652-t7ghng17 83 18 be be VB cord-269652-t7ghng17 83 19 part part NN cord-269652-t7ghng17 83 20 of of IN cord-269652-t7ghng17 83 21 routine routine JJ cord-269652-t7ghng17 83 22 sepsis sepsis NN cord-269652-t7ghng17 83 23 workup workup JJ cord-269652-t7ghng17 83 24 . . . cord-269652-t7ghng17 84 1 Microbiologic Microbiologic NNP cord-269652-t7ghng17 84 2 evaluation evaluation NN cord-269652-t7ghng17 84 3 using use VBG cord-269652-t7ghng17 84 4 gastric gastric JJ cord-269652-t7ghng17 84 5 aspirates aspirate NNS cord-269652-t7ghng17 84 6 , , , cord-269652-t7ghng17 84 7 tracheal tracheal NN cord-269652-t7ghng17 84 8 aspirates aspirate NNS cord-269652-t7ghng17 84 9 , , , cord-269652-t7ghng17 84 10 or or CC cord-269652-t7ghng17 84 11 superficial superficial JJ cord-269652-t7ghng17 84 12 body body NN cord-269652-t7ghng17 84 13 sites site NNS cord-269652-t7ghng17 84 14 cultures culture NNS cord-269652-t7ghng17 84 15 are be VBP cord-269652-t7ghng17 84 16 of of IN cord-269652-t7ghng17 84 17 limited limited JJ cord-269652-t7ghng17 84 18 value value NN cord-269652-t7ghng17 84 19 and and CC cord-269652-t7ghng17 84 20 are be VBP cord-269652-t7ghng17 84 21 not not RB cord-269652-t7ghng17 84 22 routinely routinely RB cord-269652-t7ghng17 84 23 recommended recommend VBN cord-269652-t7ghng17 84 24 for for IN cord-269652-t7ghng17 84 25 sepsis sepsis NN cord-269652-t7ghng17 84 26 . . . cord-269652-t7ghng17 85 1 Several several JJ cord-269652-t7ghng17 85 2 acute acute JJ cord-269652-t7ghng17 85 3 - - HYPH cord-269652-t7ghng17 85 4 phase phase NN cord-269652-t7ghng17 85 5 reactants reactant NNS cord-269652-t7ghng17 85 6 or or CC cord-269652-t7ghng17 85 7 biomarkers biomarker NNS cord-269652-t7ghng17 85 8 ( ( -LRB- cord-269652-t7ghng17 85 9 neutrophil neutrophil NN cord-269652-t7ghng17 85 10 CD64 CD64 NNP cord-269652-t7ghng17 85 11 [ [ -LRB- cord-269652-t7ghng17 85 12 nCD64 nCD64 NNP cord-269652-t7ghng17 85 13 ] ] -RRB- cord-269652-t7ghng17 85 14 , , , cord-269652-t7ghng17 85 15 procalcitonin procalcitonin NNS cord-269652-t7ghng17 85 16 [ [ -LRB- cord-269652-t7ghng17 85 17 PCT PCT NNP cord-269652-t7ghng17 85 18 ] ] -RRB- cord-269652-t7ghng17 85 19 , , , cord-269652-t7ghng17 85 20 or or CC cord-269652-t7ghng17 85 21 CRP CRP NNP cord-269652-t7ghng17 85 22 ) ) -RRB- cord-269652-t7ghng17 85 23 may may MD cord-269652-t7ghng17 85 24 be be VB cord-269652-t7ghng17 85 25 used use VBN cord-269652-t7ghng17 85 26 adjunctively adjunctively RB cord-269652-t7ghng17 85 27 in in IN cord-269652-t7ghng17 85 28 the the DT cord-269652-t7ghng17 85 29 evaluation evaluation NN cord-269652-t7ghng17 85 30 and and CC cord-269652-t7ghng17 85 31 management management NN cord-269652-t7ghng17 85 32 of of IN cord-269652-t7ghng17 85 33 neonatal neonatal JJ cord-269652-t7ghng17 85 34 infection infection NN cord-269652-t7ghng17 85 35 . . . cord-269652-t7ghng17 86 1 The the DT cord-269652-t7ghng17 86 2 diagnostic diagnostic JJ cord-269652-t7ghng17 86 3 usefulness usefulness NN cord-269652-t7ghng17 86 4 of of IN cord-269652-t7ghng17 86 5 the the DT cord-269652-t7ghng17 86 6 various various JJ cord-269652-t7ghng17 86 7 surrogate surrogate JJ cord-269652-t7ghng17 86 8 markers marker NNS cord-269652-t7ghng17 86 9 depends depend VBZ cord-269652-t7ghng17 86 10 on on IN cord-269652-t7ghng17 86 11 the the DT cord-269652-t7ghng17 86 12 phases phase NNS cord-269652-t7ghng17 86 13 of of IN cord-269652-t7ghng17 86 14 neonatal neonatal JJ cord-269652-t7ghng17 86 15 sepsis sepsis NN cord-269652-t7ghng17 86 16 : : : cord-269652-t7ghng17 86 17 early early JJ cord-269652-t7ghng17 86 18 phase phase NN cord-269652-t7ghng17 86 19 or or CC cord-269652-t7ghng17 86 20 2 2 CD cord-269652-t7ghng17 86 21 to to TO cord-269652-t7ghng17 86 22 12 12 CD cord-269652-t7ghng17 86 23 hours hour NNS cord-269652-t7ghng17 86 24 ( ( -LRB- cord-269652-t7ghng17 86 25 nCD64 nCD64 NNP cord-269652-t7ghng17 86 26 ) ) -RRB- cord-269652-t7ghng17 86 27 , , , cord-269652-t7ghng17 86 28 mid mid JJ cord-269652-t7ghng17 86 29 phase phase NN cord-269652-t7ghng17 86 30 or or CC cord-269652-t7ghng17 86 31 12 12 CD cord-269652-t7ghng17 86 32 - - SYM cord-269652-t7ghng17 86 33 24 24 CD cord-269652-t7ghng17 86 34 hours hour NNS cord-269652-t7ghng17 86 35 ( ( -LRB- cord-269652-t7ghng17 86 36 PCT PCT NNP cord-269652-t7ghng17 86 37 ) ) -RRB- cord-269652-t7ghng17 86 38 , , , cord-269652-t7ghng17 86 39 and and CC cord-269652-t7ghng17 86 40 late late JJ cord-269652-t7ghng17 86 41 phase phase NN cord-269652-t7ghng17 86 42 or or CC cord-269652-t7ghng17 86 43 greater great JJR cord-269652-t7ghng17 86 44 than than IN cord-269652-t7ghng17 86 45 24 24 CD cord-269652-t7ghng17 86 46 hours hour NNS cord-269652-t7ghng17 86 47 ( ( -LRB- cord-269652-t7ghng17 86 48 CRP CRP NNP cord-269652-t7ghng17 86 49 ) ) -RRB- cord-269652-t7ghng17 86 50 . . . cord-269652-t7ghng17 87 1 24 24 CD cord-269652-t7ghng17 87 2 nCD64 nCD64 NNP cord-269652-t7ghng17 87 3 is be VBZ cord-269652-t7ghng17 87 4 a a DT cord-269652-t7ghng17 87 5 high high JJ cord-269652-t7ghng17 87 6 - - HYPH cord-269652-t7ghng17 87 7 affinity affinity NN cord-269652-t7ghng17 87 8 Fc Fc NNP cord-269652-t7ghng17 87 9 receptor receptor NN cord-269652-t7ghng17 87 10 that that WDT cord-269652-t7ghng17 87 11 increases increase VBZ cord-269652-t7ghng17 87 12 with with IN cord-269652-t7ghng17 87 13 exposure exposure NN cord-269652-t7ghng17 87 14 to to IN cord-269652-t7ghng17 87 15 bacterial bacterial JJ cord-269652-t7ghng17 87 16 or or CC cord-269652-t7ghng17 87 17 fungal fungal JJ cord-269652-t7ghng17 87 18 agents agent NNS cord-269652-t7ghng17 87 19 . . . cord-269652-t7ghng17 88 1 2 2 LS cord-269652-t7ghng17 88 2 , , , cord-269652-t7ghng17 88 3 24 24 CD cord-269652-t7ghng17 89 1 The the DT cord-269652-t7ghng17 89 2 usefulness usefulness NN cord-269652-t7ghng17 89 3 of of IN cord-269652-t7ghng17 89 4 nCD64 nCD64 NNP cord-269652-t7ghng17 89 5 is be VBZ cord-269652-t7ghng17 89 6 related relate VBN cord-269652-t7ghng17 89 7 to to IN cord-269652-t7ghng17 89 8 its -PRON- PRP$ cord-269652-t7ghng17 89 9 high high JJ cord-269652-t7ghng17 89 10 negative negative JJ cord-269652-t7ghng17 89 11 predictive predictive JJ cord-269652-t7ghng17 89 12 value value NN cord-269652-t7ghng17 89 13 as as RB cord-269652-t7ghng17 89 14 well well RB cord-269652-t7ghng17 89 15 as as IN cord-269652-t7ghng17 89 16 decreasing decrease VBG cord-269652-t7ghng17 89 17 concentration concentration NN cord-269652-t7ghng17 89 18 on on IN cord-269652-t7ghng17 89 19 serial serial JJ cord-269652-t7ghng17 89 20 determinations determination NNS cord-269652-t7ghng17 89 21 on on IN cord-269652-t7ghng17 89 22 infants infant NNS cord-269652-t7ghng17 89 23 undergoing undergo VBG cord-269652-t7ghng17 89 24 antimicrobial antimicrobial JJ cord-269652-t7ghng17 89 25 treatment treatment NN cord-269652-t7ghng17 89 26 of of IN cord-269652-t7ghng17 89 27 bacteremia bacteremia NN cord-269652-t7ghng17 89 28 . . . cord-269652-t7ghng17 90 1 24 24 CD cord-269652-t7ghng17 91 1 However however RB cord-269652-t7ghng17 91 2 , , , cord-269652-t7ghng17 91 3 there there EX cord-269652-t7ghng17 91 4 is be VBZ cord-269652-t7ghng17 91 5 a a DT cord-269652-t7ghng17 91 6 scarcity scarcity NN cord-269652-t7ghng17 91 7 of of IN cord-269652-t7ghng17 91 8 medical medical JJ cord-269652-t7ghng17 91 9 evidence evidence NN cord-269652-t7ghng17 91 10 to to TO cord-269652-t7ghng17 91 11 recommend recommend VB cord-269652-t7ghng17 91 12 nCD64 nCD64 NNP cord-269652-t7ghng17 91 13 for for IN cord-269652-t7ghng17 91 14 routine routine JJ cord-269652-t7ghng17 91 15 evaluation evaluation NN cord-269652-t7ghng17 91 16 of of IN cord-269652-t7ghng17 91 17 neonatal neonatal JJ cord-269652-t7ghng17 91 18 infection infection NN cord-269652-t7ghng17 91 19 and and CC cord-269652-t7ghng17 91 20 this this DT cord-269652-t7ghng17 91 21 may may MD cord-269652-t7ghng17 91 22 not not RB cord-269652-t7ghng17 91 23 be be VB cord-269652-t7ghng17 91 24 readily readily RB cord-269652-t7ghng17 91 25 available available JJ cord-269652-t7ghng17 91 26 . . . cord-269652-t7ghng17 92 1 Procalcitonin Procalcitonin NNS cord-269652-t7ghng17 92 2 released release VBD cord-269652-t7ghng17 92 3 from from IN cord-269652-t7ghng17 92 4 tissues tissue NNS cord-269652-t7ghng17 92 5 increases increase NNS cord-269652-t7ghng17 92 6 with with IN cord-269652-t7ghng17 92 7 infection infection NN cord-269652-t7ghng17 92 8 at at IN cord-269652-t7ghng17 92 9 around around RB cord-269652-t7ghng17 92 10 2 2 CD cord-269652-t7ghng17 92 11 hours hour NNS cord-269652-t7ghng17 92 12 and and CC cord-269652-t7ghng17 92 13 peaks peak NNS cord-269652-t7ghng17 92 14 at at IN cord-269652-t7ghng17 92 15 12 12 CD cord-269652-t7ghng17 92 16 hours hour NNS cord-269652-t7ghng17 92 17 . . . cord-269652-t7ghng17 93 1 7 7 CD cord-269652-t7ghng17 94 1 It -PRON- PRP cord-269652-t7ghng17 94 2 may may MD cord-269652-t7ghng17 94 3 also also RB cord-269652-t7ghng17 94 4 increase increase VB cord-269652-t7ghng17 94 5 with with IN cord-269652-t7ghng17 94 6 noninfectious noninfectious JJ cord-269652-t7ghng17 94 7 causes cause NNS cord-269652-t7ghng17 94 8 such such JJ cord-269652-t7ghng17 94 9 as as IN cord-269652-t7ghng17 94 10 in in IN cord-269652-t7ghng17 94 11 respiratory respiratory JJ cord-269652-t7ghng17 94 12 distress distress NN cord-269652-t7ghng17 94 13 syndrome syndrome NN cord-269652-t7ghng17 94 14 and and CC cord-269652-t7ghng17 94 15 a a DT cord-269652-t7ghng17 94 16 physiologic physiologic JJ cord-269652-t7ghng17 94 17 increase increase NN cord-269652-t7ghng17 94 18 during during IN cord-269652-t7ghng17 94 19 the the DT cord-269652-t7ghng17 94 20 first first JJ cord-269652-t7ghng17 94 21 24 24 CD cord-269652-t7ghng17 94 22 hours hour NNS cord-269652-t7ghng17 94 23 of of IN cord-269652-t7ghng17 94 24 birth birth NN cord-269652-t7ghng17 94 25 . . . cord-269652-t7ghng17 95 1 7 7 CD cord-269652-t7ghng17 95 2 PCT PCT NNP cord-269652-t7ghng17 95 3 may may MD cord-269652-t7ghng17 95 4 not not RB cord-269652-t7ghng17 95 5 be be VB cord-269652-t7ghng17 95 6 readily readily RB cord-269652-t7ghng17 95 7 available available JJ cord-269652-t7ghng17 95 8 and and CC cord-269652-t7ghng17 95 9 the the DT cord-269652-t7ghng17 95 10 turnaround turnaround NN cord-269652-t7ghng17 95 11 time time NN cord-269652-t7ghng17 95 12 varies vary VBZ cord-269652-t7ghng17 95 13 in in IN cord-269652-t7ghng17 95 14 different different JJ cord-269652-t7ghng17 95 15 institutions institution NNS cord-269652-t7ghng17 95 16 from from IN cord-269652-t7ghng17 95 17 20 20 CD cord-269652-t7ghng17 95 18 minutes minute NNS cord-269652-t7ghng17 95 19 to to IN cord-269652-t7ghng17 95 20 5 5 CD cord-269652-t7ghng17 95 21 hours hour NNS cord-269652-t7ghng17 95 22 . . . cord-269652-t7ghng17 96 1 24 24 CD cord-269652-t7ghng17 96 2 CRP CRP NNP cord-269652-t7ghng17 96 3 increases increase VBZ cord-269652-t7ghng17 96 4 around around RB cord-269652-t7ghng17 96 5 6 6 CD cord-269652-t7ghng17 96 6 hours hour NNS cord-269652-t7ghng17 96 7 associated associate VBN cord-269652-t7ghng17 96 8 with with IN cord-269652-t7ghng17 96 9 an an DT cord-269652-t7ghng17 96 10 inflammatory inflammatory JJ cord-269652-t7ghng17 96 11 response response NN cord-269652-t7ghng17 96 12 with with IN cord-269652-t7ghng17 96 13 release release NN cord-269652-t7ghng17 96 14 of of IN cord-269652-t7ghng17 96 15 interleukin-6 interleukin-6 NNP cord-269652-t7ghng17 96 16 and and CC cord-269652-t7ghng17 96 17 peaks peak NNS cord-269652-t7ghng17 96 18 at at IN cord-269652-t7ghng17 96 19 24 24 CD cord-269652-t7ghng17 96 20 hours hour NNS cord-269652-t7ghng17 96 21 . . . cord-269652-t7ghng17 97 1 7 7 CD cord-269652-t7ghng17 97 2 CRP CRP NNP cord-269652-t7ghng17 97 3 has have VBZ cord-269652-t7ghng17 97 4 been be VBN cord-269652-t7ghng17 97 5 used use VBN cord-269652-t7ghng17 97 6 in in IN cord-269652-t7ghng17 97 7 the the DT cord-269652-t7ghng17 97 8 algorithm algorithm NN cord-269652-t7ghng17 97 9 - - HYPH cord-269652-t7ghng17 97 10 based base VBN cord-269652-t7ghng17 97 11 guideline guideline NN cord-269652-t7ghng17 97 12 from from IN cord-269652-t7ghng17 97 13 the the DT cord-269652-t7ghng17 97 14 AAP AAP NNP cord-269652-t7ghng17 97 15 Committee Committee NNP cord-269652-t7ghng17 97 16 on on IN cord-269652-t7ghng17 97 17 Fetus Fetus NNP cord-269652-t7ghng17 97 18 and and CC cord-269652-t7ghng17 97 19 Newborn Newborn NNP cord-269652-t7ghng17 97 20 for for IN cord-269652-t7ghng17 97 21 the the DT cord-269652-t7ghng17 97 22 evaluation evaluation NN cord-269652-t7ghng17 97 23 of of IN cord-269652-t7ghng17 97 24 asymptomatic asymptomatic JJ cord-269652-t7ghng17 97 25 term term NN cord-269652-t7ghng17 97 26 and and CC cord-269652-t7ghng17 97 27 preterm preterm JJ cord-269652-t7ghng17 97 28 infants infant NNS cord-269652-t7ghng17 97 29 with with IN cord-269652-t7ghng17 97 30 a a DT cord-269652-t7ghng17 97 31 risk risk NN cord-269652-t7ghng17 97 32 factor factor NN cord-269652-t7ghng17 97 33 for for IN cord-269652-t7ghng17 97 34 sepsis sepsis NN cord-269652-t7ghng17 97 35 . . . cord-269652-t7ghng17 98 1 7 7 CD cord-269652-t7ghng17 99 1 It -PRON- PRP cord-269652-t7ghng17 99 2 is be VBZ cord-269652-t7ghng17 99 3 best well RBS cord-269652-t7ghng17 99 4 used use VBN cord-269652-t7ghng17 99 5 as as IN cord-269652-t7ghng17 99 6 part part NN cord-269652-t7ghng17 99 7 of of IN cord-269652-t7ghng17 99 8 a a DT cord-269652-t7ghng17 99 9 group group NN cord-269652-t7ghng17 99 10 of of IN cord-269652-t7ghng17 99 11 diagnostic diagnostic JJ cord-269652-t7ghng17 99 12 tests test NNS cord-269652-t7ghng17 99 13 2 2 CD cord-269652-t7ghng17 99 14 together together RB cord-269652-t7ghng17 99 15 with with IN cord-269652-t7ghng17 99 16 blood blood NN cord-269652-t7ghng17 99 17 culture culture NN cord-269652-t7ghng17 99 18 and and CC cord-269652-t7ghng17 99 19 white white JJ cord-269652-t7ghng17 99 20 blood blood NN cord-269652-t7ghng17 99 21 cell cell NN cord-269652-t7ghng17 99 22 with with IN cord-269652-t7ghng17 99 23 differential differential NN cord-269652-t7ghng17 99 24 in in IN cord-269652-t7ghng17 99 25 the the DT cord-269652-t7ghng17 99 26 evaluation evaluation NN cord-269652-t7ghng17 99 27 of of IN cord-269652-t7ghng17 99 28 neonatal neonatal JJ cord-269652-t7ghng17 99 29 infection infection NN cord-269652-t7ghng17 99 30 . . . cord-269652-t7ghng17 100 1 7 7 CD cord-269652-t7ghng17 101 1 However however RB cord-269652-t7ghng17 101 2 , , , cord-269652-t7ghng17 101 3 there there EX cord-269652-t7ghng17 101 4 is be VBZ cord-269652-t7ghng17 101 5 not not RB cord-269652-t7ghng17 101 6 enough enough JJ cord-269652-t7ghng17 101 7 medical medical JJ cord-269652-t7ghng17 101 8 evidence evidence NN cord-269652-t7ghng17 101 9 at at IN cord-269652-t7ghng17 101 10 this this DT cord-269652-t7ghng17 101 11 time time NN cord-269652-t7ghng17 101 12 to to TO cord-269652-t7ghng17 101 13 recommend recommend VB cord-269652-t7ghng17 101 14 serial serial JJ cord-269652-t7ghng17 101 15 determinations determination NNS cord-269652-t7ghng17 101 16 of of IN cord-269652-t7ghng17 101 17 CRP CRP NNP cord-269652-t7ghng17 101 18 in in IN cord-269652-t7ghng17 101 19 guiding guide VBG cord-269652-t7ghng17 101 20 duration duration NN cord-269652-t7ghng17 101 21 of of IN cord-269652-t7ghng17 101 22 antimicrobial antimicrobial JJ cord-269652-t7ghng17 101 23 therapy therapy NN cord-269652-t7ghng17 101 24 in in IN cord-269652-t7ghng17 101 25 infants infant NNS cord-269652-t7ghng17 101 26 . . . cord-269652-t7ghng17 102 1 7 7 CD cord-269652-t7ghng17 102 2 , , , cord-269652-t7ghng17 102 3 24 24 CD cord-269652-t7ghng17 103 1 Further further JJ cord-269652-t7ghng17 103 2 studies study NNS cord-269652-t7ghng17 103 3 are be VBP cord-269652-t7ghng17 103 4 needed need VBN cord-269652-t7ghng17 103 5 to to TO cord-269652-t7ghng17 103 6 evaluate evaluate VB cord-269652-t7ghng17 103 7 the the DT cord-269652-t7ghng17 103 8 usefulness usefulness NN cord-269652-t7ghng17 103 9 of of IN cord-269652-t7ghng17 103 10 sequential sequential JJ cord-269652-t7ghng17 103 11 determination determination NN cord-269652-t7ghng17 103 12 of of IN cord-269652-t7ghng17 103 13 CRP crp NN cord-269652-t7ghng17 103 14 and and CC cord-269652-t7ghng17 103 15 biomarkers biomarker NNS cord-269652-t7ghng17 103 16 for for IN cord-269652-t7ghng17 103 17 an an DT cord-269652-t7ghng17 103 18 antimicrobial antimicrobial JJ cord-269652-t7ghng17 103 19 stewardship stewardship NN cord-269652-t7ghng17 103 20 program program NN cord-269652-t7ghng17 103 21 ( ( -LRB- cord-269652-t7ghng17 103 22 ASP ASP NNP cord-269652-t7ghng17 103 23 ) ) -RRB- cord-269652-t7ghng17 103 24 in in IN cord-269652-t7ghng17 103 25 the the DT cord-269652-t7ghng17 103 26 NICU NICU NNP cord-269652-t7ghng17 103 27 setting setting NN cord-269652-t7ghng17 103 28 . . . cord-269652-t7ghng17 104 1 In in IN cord-269652-t7ghng17 104 2 2013 2013 CD cord-269652-t7ghng17 104 3 , , , cord-269652-t7ghng17 104 4 the the DT cord-269652-t7ghng17 104 5 Infectious Infectious NNP cord-269652-t7ghng17 104 6 Disease Disease NNP cord-269652-t7ghng17 104 7 Society Society NNP cord-269652-t7ghng17 104 8 of of IN cord-269652-t7ghng17 104 9 America America NNP cord-269652-t7ghng17 104 10 , , , cord-269652-t7ghng17 104 11 in in IN cord-269652-t7ghng17 104 12 collaboration collaboration NN cord-269652-t7ghng17 104 13 with with IN cord-269652-t7ghng17 104 14 the the DT cord-269652-t7ghng17 104 15 American American NNP cord-269652-t7ghng17 104 16 Society Society NNP cord-269652-t7ghng17 104 17 for for IN cord-269652-t7ghng17 104 18 Microbiology Microbiology NNP cord-269652-t7ghng17 104 19 , , , cord-269652-t7ghng17 104 20 affirmed affirm VBD cord-269652-t7ghng17 104 21 the the DT cord-269652-t7ghng17 104 22 importance importance NN cord-269652-t7ghng17 104 23 of of IN cord-269652-t7ghng17 104 24 close close JJ cord-269652-t7ghng17 104 25 collaboration collaboration NN cord-269652-t7ghng17 104 26 and and CC cord-269652-t7ghng17 104 27 positive positive JJ cord-269652-t7ghng17 104 28 working work VBG cord-269652-t7ghng17 104 29 relationships relationship NNS cord-269652-t7ghng17 104 30 between between IN cord-269652-t7ghng17 104 31 clinicians clinician NNS cord-269652-t7ghng17 104 32 and and CC cord-269652-t7ghng17 104 33 microbiologists microbiologist NNS cord-269652-t7ghng17 104 34 25 25 CD cord-269652-t7ghng17 104 35 to to TO cord-269652-t7ghng17 104 36 better better RB cord-269652-t7ghng17 104 37 serve serve VB cord-269652-t7ghng17 104 38 patients patient NNS cord-269652-t7ghng17 104 39 . . . cord-269652-t7ghng17 105 1 The the DT cord-269652-t7ghng17 105 2 most most RBS cord-269652-t7ghng17 105 3 up up IN cord-269652-t7ghng17 105 4 - - HYPH cord-269652-t7ghng17 105 5 to to IN cord-269652-t7ghng17 105 6 - - HYPH cord-269652-t7ghng17 105 7 date date NN cord-269652-t7ghng17 105 8 edition edition NN cord-269652-t7ghng17 105 9 of of IN cord-269652-t7ghng17 105 10 the the DT cord-269652-t7ghng17 105 11 Red Red NNP cord-269652-t7ghng17 105 12 Book Book NNP cord-269652-t7ghng17 105 13 provides provide VBZ cord-269652-t7ghng17 105 14 contact contact NN cord-269652-t7ghng17 105 15 information information NN cord-269652-t7ghng17 105 16 for for IN cord-269652-t7ghng17 105 17 expert expert JJ cord-269652-t7ghng17 105 18 advice advice NN cord-269652-t7ghng17 105 19 and and CC cord-269652-t7ghng17 105 20 national national JJ cord-269652-t7ghng17 105 21 collaborative collaborative JJ cord-269652-t7ghng17 105 22 study study NN cord-269652-t7ghng17 105 23 groups group NNS cord-269652-t7ghng17 105 24 that that WDT cord-269652-t7ghng17 105 25 give give VBP cord-269652-t7ghng17 105 26 guidance guidance NN cord-269652-t7ghng17 105 27 on on IN cord-269652-t7ghng17 105 28 diagnostic diagnostic JJ cord-269652-t7ghng17 105 29 assays assay NNS cord-269652-t7ghng17 105 30 regarding regard VBG cord-269652-t7ghng17 105 31 specific specific JJ cord-269652-t7ghng17 105 32 agents agent NNS cord-269652-t7ghng17 105 33 causing cause VBG cord-269652-t7ghng17 105 34 mother mother NN cord-269652-t7ghng17 105 35 - - HYPH cord-269652-t7ghng17 105 36 to to IN cord-269652-t7ghng17 105 37 - - HYPH cord-269652-t7ghng17 105 38 child child NN cord-269652-t7ghng17 105 39 transmission transmission NN cord-269652-t7ghng17 105 40 . . . cord-269652-t7ghng17 106 1 It -PRON- PRP cord-269652-t7ghng17 106 2 is be VBZ cord-269652-t7ghng17 106 3 important important JJ cord-269652-t7ghng17 106 4 to to TO cord-269652-t7ghng17 106 5 know know VB cord-269652-t7ghng17 106 6 the the DT cord-269652-t7ghng17 106 7 various various JJ cord-269652-t7ghng17 106 8 microbiologic microbiologic JJ cord-269652-t7ghng17 106 9 resources resource NNS cord-269652-t7ghng17 106 10 available available JJ cord-269652-t7ghng17 106 11 locally locally RB cord-269652-t7ghng17 106 12 , , , cord-269652-t7ghng17 106 13 which which WDT cord-269652-t7ghng17 106 14 include include VBP cord-269652-t7ghng17 106 15 but but CC cord-269652-t7ghng17 106 16 are be VBP cord-269652-t7ghng17 106 17 not not RB cord-269652-t7ghng17 106 18 limited limited JJ cord-269652-t7ghng17 106 19 to to IN cord-269652-t7ghng17 106 20 PCR PCR NNP cord-269652-t7ghng17 106 21 and and CC cord-269652-t7ghng17 106 22 matrix matrix NN cord-269652-t7ghng17 106 23 - - HYPH cord-269652-t7ghng17 106 24 assisted assist VBN cord-269652-t7ghng17 106 25 laser laser NN cord-269652-t7ghng17 106 26 desorption desorption NN cord-269652-t7ghng17 106 27 ionization ionization NN cord-269652-t7ghng17 106 28 - - HYPH cord-269652-t7ghng17 106 29 time time NN cord-269652-t7ghng17 106 30 of of IN cord-269652-t7ghng17 106 31 flight flight NN cord-269652-t7ghng17 106 32 mass mass NN cord-269652-t7ghng17 106 33 spectrometry spectrometry NN cord-269652-t7ghng17 106 34 ( ( -LRB- cord-269652-t7ghng17 106 35 MALDI MALDI NNP cord-269652-t7ghng17 106 36 - - HYPH cord-269652-t7ghng17 106 37 TOF TOF NNP cord-269652-t7ghng17 106 38 ) ) -RRB- cord-269652-t7ghng17 106 39 . . . cord-269652-t7ghng17 107 1 Rapid rapid JJ cord-269652-t7ghng17 107 2 antigen antigen NN cord-269652-t7ghng17 107 3 tests test NNS cord-269652-t7ghng17 107 4 for for IN cord-269652-t7ghng17 107 5 respiratory respiratory JJ cord-269652-t7ghng17 107 6 viruses virus NNS cord-269652-t7ghng17 107 7 may may MD cord-269652-t7ghng17 107 8 lack lack VB cord-269652-t7ghng17 107 9 sensitivity sensitivity NN cord-269652-t7ghng17 107 10 , , , cord-269652-t7ghng17 107 11 25 25 CD cord-269652-t7ghng17 107 12 which which WDT cord-269652-t7ghng17 107 13 is be VBZ cord-269652-t7ghng17 107 14 important important JJ cord-269652-t7ghng17 107 15 in in IN cord-269652-t7ghng17 107 16 the the DT cord-269652-t7ghng17 107 17 NICU NICU NNP cord-269652-t7ghng17 107 18 setting set VBG cord-269652-t7ghng17 107 19 in in RP cord-269652-t7ghng17 107 20 controlling control VBG cord-269652-t7ghng17 107 21 local local JJ cord-269652-t7ghng17 107 22 outbreaks outbreak NNS cord-269652-t7ghng17 107 23 . . . cord-269652-t7ghng17 108 1 There there EX cord-269652-t7ghng17 108 2 are be VBP cord-269652-t7ghng17 108 3 several several JJ cord-269652-t7ghng17 108 4 nucleic nucleic JJ cord-269652-t7ghng17 108 5 acid acid NN cord-269652-t7ghng17 108 6 amplification amplification NN cord-269652-t7ghng17 108 7 test test NN cord-269652-t7ghng17 108 8 platforms platform NNS cord-269652-t7ghng17 108 9 currently currently RB cord-269652-t7ghng17 108 10 available available JJ cord-269652-t7ghng17 108 11 that that IN cord-269652-t7ghng17 108 12 differ differ VBP cord-269652-t7ghng17 108 13 in in IN cord-269652-t7ghng17 108 14 the the DT cord-269652-t7ghng17 108 15 number number NN cord-269652-t7ghng17 108 16 of of IN cord-269652-t7ghng17 108 17 analytes analyte NNS cord-269652-t7ghng17 108 18 detected detect VBN cord-269652-t7ghng17 108 19 . . . cord-269652-t7ghng17 109 1 25 25 CD cord-269652-t7ghng17 110 1 It -PRON- PRP cord-269652-t7ghng17 110 2 is be VBZ cord-269652-t7ghng17 110 3 important important JJ cord-269652-t7ghng17 110 4 to to TO cord-269652-t7ghng17 110 5 obtain obtain VB cord-269652-t7ghng17 110 6 adequate adequate JJ cord-269652-t7ghng17 110 7 specimens specimen NNS cord-269652-t7ghng17 110 8 and and CC cord-269652-t7ghng17 110 9 to to TO cord-269652-t7ghng17 110 10 use use VB cord-269652-t7ghng17 110 11 suitable suitable JJ cord-269652-t7ghng17 110 12 viral viral JJ cord-269652-t7ghng17 110 13 transport transport NN cord-269652-t7ghng17 110 14 media medium NNS cord-269652-t7ghng17 110 15 following follow VBG cord-269652-t7ghng17 110 16 manufacturer manufacturer NN cord-269652-t7ghng17 110 17 instructions instruction NNS cord-269652-t7ghng17 110 18 . . . cord-269652-t7ghng17 111 1 MALDI MALDI NNP cord-269652-t7ghng17 111 2 - - HYPH cord-269652-t7ghng17 111 3 TOF TOF NNP cord-269652-t7ghng17 111 4 is be VBZ cord-269652-t7ghng17 111 5 a a DT cord-269652-t7ghng17 111 6 valuable valuable JJ cord-269652-t7ghng17 111 7 alternative alternative NN cord-269652-t7ghng17 111 8 to to IN cord-269652-t7ghng17 111 9 the the DT cord-269652-t7ghng17 111 10 conventional conventional JJ cord-269652-t7ghng17 111 11 microbiologic microbiologic JJ cord-269652-t7ghng17 111 12 assays assay NNS cord-269652-t7ghng17 111 13 ; ; : cord-269652-t7ghng17 111 14 however however RB cord-269652-t7ghng17 111 15 , , , cord-269652-t7ghng17 111 16 it -PRON- PRP cord-269652-t7ghng17 111 17 may may MD cord-269652-t7ghng17 111 18 not not RB cord-269652-t7ghng17 111 19 be be VB cord-269652-t7ghng17 111 20 a a DT cord-269652-t7ghng17 111 21 readily readily RB cord-269652-t7ghng17 111 22 available available JJ cord-269652-t7ghng17 111 23 resource resource NN cord-269652-t7ghng17 111 24 for for IN cord-269652-t7ghng17 111 25 diagnostic diagnostic JJ cord-269652-t7ghng17 111 26 testing testing NN cord-269652-t7ghng17 111 27 in in IN cord-269652-t7ghng17 111 28 most most JJS cord-269652-t7ghng17 111 29 institutions institution NNS cord-269652-t7ghng17 111 30 . . . cord-269652-t7ghng17 112 1 However however RB cord-269652-t7ghng17 112 2 , , , cord-269652-t7ghng17 112 3 if if IN cord-269652-t7ghng17 112 4 it -PRON- PRP cord-269652-t7ghng17 112 5 is be VBZ cord-269652-t7ghng17 112 6 available available JJ cord-269652-t7ghng17 112 7 , , , cord-269652-t7ghng17 112 8 it -PRON- PRP cord-269652-t7ghng17 112 9 has have VBZ cord-269652-t7ghng17 112 10 several several JJ cord-269652-t7ghng17 112 11 practical practical JJ cord-269652-t7ghng17 112 12 applications application NNS cord-269652-t7ghng17 112 13 that that WDT cord-269652-t7ghng17 112 14 may may MD cord-269652-t7ghng17 112 15 benefit benefit VB cord-269652-t7ghng17 112 16 clinical clinical JJ cord-269652-t7ghng17 112 17 management management NN cord-269652-t7ghng17 112 18 even even RB cord-269652-t7ghng17 112 19 in in IN cord-269652-t7ghng17 112 20 the the DT cord-269652-t7ghng17 112 21 NICU NICU NNP cord-269652-t7ghng17 112 22 settings setting NNS cord-269652-t7ghng17 112 23 : : : cord-269652-t7ghng17 113 1 Earlier early RBR cord-269652-t7ghng17 113 2 and and CC cord-269652-t7ghng17 113 3 accurate accurate JJ cord-269652-t7ghng17 113 4 diagnosis diagnosis NN cord-269652-t7ghng17 113 5 of of IN cord-269652-t7ghng17 113 6 neonatal neonatal JJ cord-269652-t7ghng17 113 7 sepsis sepsis NN cord-269652-t7ghng17 113 8 due due IN cord-269652-t7ghng17 113 9 to to IN cord-269652-t7ghng17 113 10 various various JJ cord-269652-t7ghng17 113 11 bacteria bacteria NNS cord-269652-t7ghng17 113 12 26 26 CD cord-269652-t7ghng17 113 13 Rapid rapid JJ cord-269652-t7ghng17 113 14 identification identification NN cord-269652-t7ghng17 113 15 of of IN cord-269652-t7ghng17 113 16 highly highly RB cord-269652-t7ghng17 113 17 virulent virulent JJ cord-269652-t7ghng17 113 18 GBS GBS NNP cord-269652-t7ghng17 113 19 that that WDT cord-269652-t7ghng17 113 20 causes cause VBZ cord-269652-t7ghng17 113 21 meningitis meningitis NN cord-269652-t7ghng17 113 22 and and CC cord-269652-t7ghng17 113 23 LOS LOS NNP cord-269652-t7ghng17 113 24 in in IN cord-269652-t7ghng17 113 25 infants infant NNS cord-269652-t7ghng17 113 26 27 27 CD cord-269652-t7ghng17 113 27 Identification identification NN cord-269652-t7ghng17 113 28 of of IN cord-269652-t7ghng17 113 29 maternal maternal JJ cord-269652-t7ghng17 113 30 - - HYPH cord-269652-t7ghng17 113 31 to to IN cord-269652-t7ghng17 113 32 - - HYPH cord-269652-t7ghng17 113 33 child child NN cord-269652-t7ghng17 113 34 transmissions transmission NNS cord-269652-t7ghng17 113 35 ( ( -LRB- cord-269652-t7ghng17 113 36 chorioamnionitis chorioamnionitis JJ cord-269652-t7ghng17 113 37 and and CC cord-269652-t7ghng17 113 38 neonatal neonatal JJ cord-269652-t7ghng17 113 39 infections infection NNS cord-269652-t7ghng17 113 40 ) ) -RRB- cord-269652-t7ghng17 113 41 of of IN cord-269652-t7ghng17 113 42 opportunistic opportunistic JJ cord-269652-t7ghng17 113 43 pathogen pathogen NN cord-269652-t7ghng17 113 44 28 28 CD cord-269652-t7ghng17 113 45 Accurate accurate JJ cord-269652-t7ghng17 113 46 identification identification NN cord-269652-t7ghng17 113 47 of of IN cord-269652-t7ghng17 113 48 bloodstream bloodstream NN cord-269652-t7ghng17 113 49 infection infection NN cord-269652-t7ghng17 113 50 associated associate VBN cord-269652-t7ghng17 113 51 with with IN cord-269652-t7ghng17 113 52 fungal fungal JJ cord-269652-t7ghng17 113 53 infections infection NNS cord-269652-t7ghng17 113 54 in in IN cord-269652-t7ghng17 113 55 the the DT cord-269652-t7ghng17 113 56 NICU NICU NNP cord-269652-t7ghng17 113 57 29 29 CD cord-269652-t7ghng17 113 58 Identification Identification NNP cord-269652-t7ghng17 113 59 and and CC cord-269652-t7ghng17 113 60 monitoring monitor VBG cord-269652-t7ghng17 113 61 the the DT cord-269652-t7ghng17 113 62 spread spread NN cord-269652-t7ghng17 113 63 of of IN cord-269652-t7ghng17 113 64 nosocomial nosocomial JJ cord-269652-t7ghng17 113 65 outbreak outbreak NN cord-269652-t7ghng17 113 66 ( ( -LRB- cord-269652-t7ghng17 113 67 eg eg IN cord-269652-t7ghng17 113 68 , , , cord-269652-t7ghng17 113 69 methicillinresistant methicillinresistant JJ cord-269652-t7ghng17 113 70 Staphylococcus Staphylococcus NNP cord-269652-t7ghng17 113 71 aureus aureus NN cord-269652-t7ghng17 113 72 [ [ -LRB- cord-269652-t7ghng17 113 73 MRSA MRSA NNP cord-269652-t7ghng17 113 74 ] ] -RRB- cord-269652-t7ghng17 114 1 30 30 CD cord-269652-t7ghng17 114 2 and and CC cord-269652-t7ghng17 114 3 Candida Candida NNP cord-269652-t7ghng17 114 4 parapsilosis parapsilosis NNP cord-269652-t7ghng17 114 5 31 31 CD cord-269652-t7ghng17 114 6 in in IN cord-269652-t7ghng17 114 7 the the DT cord-269652-t7ghng17 114 8 NICU NICU NNP cord-269652-t7ghng17 114 9 ) ) -RRB- cord-269652-t7ghng17 114 10 . . . cord-269652-t7ghng17 115 1 When when WRB cord-269652-t7ghng17 115 2 appropriate appropriate JJ cord-269652-t7ghng17 115 3 specimens specimen NNS cord-269652-t7ghng17 115 4 for for IN cord-269652-t7ghng17 115 5 diagnostic diagnostic JJ cord-269652-t7ghng17 115 6 evaluations evaluation NNS cord-269652-t7ghng17 115 7 are be VBP cord-269652-t7ghng17 115 8 collected collect VBN cord-269652-t7ghng17 115 9 in in IN cord-269652-t7ghng17 115 10 clinically clinically RB cord-269652-t7ghng17 115 11 stable stable JJ cord-269652-t7ghng17 115 12 patients patient NNS cord-269652-t7ghng17 115 13 , , , cord-269652-t7ghng17 115 14 then then RB cord-269652-t7ghng17 115 15 empirical empirical JJ cord-269652-t7ghng17 115 16 antimicrobial antimicrobial JJ cord-269652-t7ghng17 115 17 therapy therapy NN cord-269652-t7ghng17 115 18 should should MD cord-269652-t7ghng17 115 19 be be VB cord-269652-t7ghng17 115 20 initiated initiate VBN cord-269652-t7ghng17 115 21 for for IN cord-269652-t7ghng17 115 22 neonatal neonatal JJ cord-269652-t7ghng17 115 23 sepsis sepsis NN cord-269652-t7ghng17 115 24 . . . cord-269652-t7ghng17 116 1 It -PRON- PRP cord-269652-t7ghng17 116 2 is be VBZ cord-269652-t7ghng17 116 3 recommended recommend VBN cord-269652-t7ghng17 116 4 to to TO cord-269652-t7ghng17 116 5 discuss discuss VB cord-269652-t7ghng17 116 6 complicated complicated JJ cord-269652-t7ghng17 116 7 cases case NNS cord-269652-t7ghng17 116 8 , , , cord-269652-t7ghng17 116 9 such such JJ cord-269652-t7ghng17 116 10 as as IN cord-269652-t7ghng17 116 11 multidrug multidrug NN cord-269652-t7ghng17 116 12 resistant resistant JJ cord-269652-t7ghng17 116 13 organisms organism NNS cord-269652-t7ghng17 116 14 and and CC cord-269652-t7ghng17 116 15 infants infant NNS cord-269652-t7ghng17 116 16 not not RB cord-269652-t7ghng17 116 17 improving improve VBG cord-269652-t7ghng17 116 18 while while IN cord-269652-t7ghng17 116 19 on on IN cord-269652-t7ghng17 116 20 therapy therapy NN cord-269652-t7ghng17 116 21 or or CC cord-269652-t7ghng17 116 22 those those DT cord-269652-t7ghng17 116 23 requiring require VBG cord-269652-t7ghng17 116 24 unconventional unconventional JJ cord-269652-t7ghng17 116 25 dosing dose VBG cord-269652-t7ghng17 116 26 regimens regimen NNS cord-269652-t7ghng17 116 27 and and CC cord-269652-t7ghng17 116 28 antimicrobial antimicrobial JJ cord-269652-t7ghng17 116 29 agents agent NNS cord-269652-t7ghng17 116 30 , , , cord-269652-t7ghng17 116 31 with with IN cord-269652-t7ghng17 116 32 pediatric pediatric JJ cord-269652-t7ghng17 116 33 infectious infectious JJ cord-269652-t7ghng17 116 34 disease disease NN cord-269652-t7ghng17 116 35 specialists specialist NNS cord-269652-t7ghng17 116 36 . . . cord-269652-t7ghng17 117 1 Ampicillin Ampicillin NNP cord-269652-t7ghng17 117 2 and and CC cord-269652-t7ghng17 117 3 gentamicin gentamicin NN cord-269652-t7ghng17 117 4 remains remain VBZ cord-269652-t7ghng17 117 5 the the DT cord-269652-t7ghng17 117 6 cornerstone cornerstone NN cord-269652-t7ghng17 117 7 of of IN cord-269652-t7ghng17 117 8 initial initial JJ cord-269652-t7ghng17 117 9 antimicrobial antimicrobial JJ cord-269652-t7ghng17 117 10 regimen regimen NN cord-269652-t7ghng17 117 11 for for IN cord-269652-t7ghng17 117 12 early early JJ cord-269652-t7ghng17 117 13 - - HYPH cord-269652-t7ghng17 117 14 onset onset NN cord-269652-t7ghng17 117 15 neonatal neonatal JJ cord-269652-t7ghng17 117 16 infections infection NNS cord-269652-t7ghng17 117 17 . . . cord-269652-t7ghng17 118 1 The the DT cord-269652-t7ghng17 118 2 combination combination NN cord-269652-t7ghng17 118 3 of of IN cord-269652-t7ghng17 118 4 such such JJ cord-269652-t7ghng17 118 5 broad broad JJ cord-269652-t7ghng17 118 6 - - HYPH cord-269652-t7ghng17 118 7 spectrum spectrum NN cord-269652-t7ghng17 118 8 antibiotic antibiotic NN cord-269652-t7ghng17 118 9 regimens regimen NNS cord-269652-t7ghng17 118 10 cover cover VBP cord-269652-t7ghng17 118 11 the the DT cord-269652-t7ghng17 118 12 most most RBS cord-269652-t7ghng17 118 13 common common JJ cord-269652-t7ghng17 118 14 cause cause NN cord-269652-t7ghng17 118 15 ( ( -LRB- cord-269652-t7ghng17 118 16 GBS GBS NNP cord-269652-t7ghng17 118 17 and and CC cord-269652-t7ghng17 118 18 E e NN cord-269652-t7ghng17 118 19 coli coli NNS cord-269652-t7ghng17 118 20 in in IN cord-269652-t7ghng17 118 21 more more JJR cord-269652-t7ghng17 118 22 than than IN cord-269652-t7ghng17 118 23 70 70 CD cord-269652-t7ghng17 118 24 % % NN cord-269652-t7ghng17 118 25 ) ) -RRB- cord-269652-t7ghng17 118 26 1 1 CD cord-269652-t7ghng17 118 27 of of IN cord-269652-t7ghng17 118 28 EOS EOS NNP cord-269652-t7ghng17 118 29 and and CC cord-269652-t7ghng17 118 30 has have VBZ cord-269652-t7ghng17 118 31 synergistic synergistic JJ cord-269652-t7ghng17 118 32 activity activity NN cord-269652-t7ghng17 118 33 ( ( -LRB- cord-269652-t7ghng17 118 34 against against IN cord-269652-t7ghng17 118 35 GBS GBS NNP cord-269652-t7ghng17 118 36 and and CC cord-269652-t7ghng17 118 37 Listeria Listeria NNP cord-269652-t7ghng17 118 38 monocytogenes monocytogenes NNP cord-269652-t7ghng17 118 39 ) ) -RRB- cord-269652-t7ghng17 118 40 . . . cord-269652-t7ghng17 119 1 7 7 CD cord-269652-t7ghng17 119 2 , , , cord-269652-t7ghng17 119 3 32 32 CD cord-269652-t7ghng17 120 1 The the DT cord-269652-t7ghng17 120 2 dosing dose VBG cord-269652-t7ghng17 120 3 regimen regimen NN cord-269652-t7ghng17 120 4 for for IN cord-269652-t7ghng17 120 5 ampicillin ampicillin NN cord-269652-t7ghng17 120 6 may may MD cord-269652-t7ghng17 120 7 change change VB cord-269652-t7ghng17 120 8 over over IN cord-269652-t7ghng17 120 9 time time NN cord-269652-t7ghng17 120 10 based base VBN cord-269652-t7ghng17 120 11 on on IN cord-269652-t7ghng17 120 12 the the DT cord-269652-t7ghng17 120 13 chronologic chronologic NN cord-269652-t7ghng17 120 14 age age NN cord-269652-t7ghng17 120 15 of of IN cord-269652-t7ghng17 120 16 the the DT cord-269652-t7ghng17 120 17 infant infant NN cord-269652-t7ghng17 120 18 and and CC cord-269652-t7ghng17 120 19 body body NN cord-269652-t7ghng17 120 20 weight weight NN cord-269652-t7ghng17 120 21 . . . cord-269652-t7ghng17 121 1 32 32 CD cord-269652-t7ghng17 122 1 For for IN cord-269652-t7ghng17 122 2 example example NN cord-269652-t7ghng17 122 3 , , , cord-269652-t7ghng17 122 4 an an DT cord-269652-t7ghng17 122 5 8-day 8-day JJ cord-269652-t7ghng17 122 6 - - HYPH cord-269652-t7ghng17 122 7 old old JJ cord-269652-t7ghng17 122 8 infant infant NN cord-269652-t7ghng17 122 9 weighing weigh VBG cord-269652-t7ghng17 122 10 greater great JJR cord-269652-t7ghng17 122 11 than than IN cord-269652-t7ghng17 122 12 2000 2000 CD cord-269652-t7ghng17 122 13 g g NN cord-269652-t7ghng17 122 14 may may MD cord-269652-t7ghng17 122 15 need need VB cord-269652-t7ghng17 122 16 dosing dosing NN cord-269652-t7ghng17 122 17 adjustment adjustment NN cord-269652-t7ghng17 122 18 of of IN cord-269652-t7ghng17 122 19 ampicillin ampicillin NN cord-269652-t7ghng17 122 20 from from IN cord-269652-t7ghng17 122 21 150 150 CD cord-269652-t7ghng17 123 1 mg mg NNP cord-269652-t7ghng17 123 2 / / SYM cord-269652-t7ghng17 123 3 kg kg NNP cord-269652-t7ghng17 123 4 / / SYM cord-269652-t7ghng17 123 5 d d LS cord-269652-t7ghng17 123 6 intravenous intravenous NN cord-269652-t7ghng17 123 7 ( ( -LRB- cord-269652-t7ghng17 123 8 IV IV NNP cord-269652-t7ghng17 123 9 ) ) -RRB- cord-269652-t7ghng17 123 10 divided divide VBD cord-269652-t7ghng17 123 11 every every DT cord-269652-t7ghng17 123 12 8 8 CD cord-269652-t7ghng17 123 13 hours hour NNS cord-269652-t7ghng17 123 14 to to IN cord-269652-t7ghng17 123 15 200 200 CD cord-269652-t7ghng17 123 16 mg mg NNP cord-269652-t7ghng17 123 17 / / SYM cord-269652-t7ghng17 123 18 kg kg NNP cord-269652-t7ghng17 123 19 / / SYM cord-269652-t7ghng17 123 20 d d NN cord-269652-t7ghng17 123 21 IV IV NNP cord-269652-t7ghng17 123 22 divided divide VBD cord-269652-t7ghng17 123 23 every every DT cord-269652-t7ghng17 123 24 6 6 CD cord-269652-t7ghng17 123 25 hours hour NNS cord-269652-t7ghng17 123 26 . . . cord-269652-t7ghng17 124 1 Once once RB cord-269652-t7ghng17 124 2 - - HYPH cord-269652-t7ghng17 124 3 daily daily RB cord-269652-t7ghng17 124 4 dosing dosing NN cord-269652-t7ghng17 124 5 of of IN cord-269652-t7ghng17 124 6 gentamicin gentamicin NNP cord-269652-t7ghng17 124 7 ( ( -LRB- cord-269652-t7ghng17 124 8 4 4 CD cord-269652-t7ghng17 124 9 mg mg NNP cord-269652-t7ghng17 124 10 / / SYM cord-269652-t7ghng17 124 11 kg kg NNP cord-269652-t7ghng17 124 12 IV IV NNP cord-269652-t7ghng17 124 13 qd qd NNP cord-269652-t7ghng17 124 14 ) ) -RRB- cord-269652-t7ghng17 124 15 32 32 CD cord-269652-t7ghng17 124 16 has have VBZ cord-269652-t7ghng17 124 17 been be VBN cord-269652-t7ghng17 124 18 used use VBN cord-269652-t7ghng17 124 19 in in IN cord-269652-t7ghng17 124 20 the the DT cord-269652-t7ghng17 124 21 term term NN cord-269652-t7ghng17 124 22 newborn newborn JJ cord-269652-t7ghng17 124 23 for for IN cord-269652-t7ghng17 124 24 more more JJR cord-269652-t7ghng17 124 25 than than IN cord-269652-t7ghng17 124 26 a a DT cord-269652-t7ghng17 124 27 decade decade NN cord-269652-t7ghng17 124 28 . . . cord-269652-t7ghng17 125 1 The the DT cord-269652-t7ghng17 125 2 pharmacodynamic pharmacodynamic JJ cord-269652-t7ghng17 125 3 characteristics characteristic NNS cord-269652-t7ghng17 125 4 of of IN cord-269652-t7ghng17 125 5 aminoglycosides aminoglycoside NNS cord-269652-t7ghng17 125 6 that that WDT cord-269652-t7ghng17 125 7 allow allow VBP cord-269652-t7ghng17 125 8 the the DT cord-269652-t7ghng17 125 9 use use NN cord-269652-t7ghng17 125 10 of of IN cord-269652-t7ghng17 125 11 once once RB cord-269652-t7ghng17 125 12 - - HYPH cord-269652-t7ghng17 125 13 daily daily NN cord-269652-t7ghng17 125 14 dosing dosing NN cord-269652-t7ghng17 125 15 include include VBP cord-269652-t7ghng17 125 16 concentration concentration NN cord-269652-t7ghng17 125 17 - - HYPH cord-269652-t7ghng17 125 18 dependent dependent JJ cord-269652-t7ghng17 125 19 killing killing NN cord-269652-t7ghng17 125 20 ( ( -LRB- cord-269652-t7ghng17 125 21 peak peak NN cord-269652-t7ghng17 125 22 concentration concentration NN cord-269652-t7ghng17 125 23 to to IN cord-269652-t7ghng17 125 24 minimal minimal JJ cord-269652-t7ghng17 125 25 inhibitory inhibitory JJ cord-269652-t7ghng17 125 26 concentration concentration NN cord-269652-t7ghng17 125 27 [ [ -LRB- cord-269652-t7ghng17 125 28 peak peak NN cord-269652-t7ghng17 125 29 / / SYM cord-269652-t7ghng17 125 30 MIC MIC NNP cord-269652-t7ghng17 125 31 ] ] -RRB- cord-269652-t7ghng17 125 32 ratio ratio NN cord-269652-t7ghng17 125 33 ) ) -RRB- cord-269652-t7ghng17 125 34 , , , cord-269652-t7ghng17 125 35 33 33 CD cord-269652-t7ghng17 125 36 , , , cord-269652-t7ghng17 125 37 34 34 CD cord-269652-t7ghng17 125 38 postantibiotic postantibiotic JJ cord-269652-t7ghng17 125 39 effect effect NN cord-269652-t7ghng17 125 40 with with IN cord-269652-t7ghng17 125 41 leukocyte leukocyte NN cord-269652-t7ghng17 125 42 enhancement enhancement NN cord-269652-t7ghng17 125 43 , , , cord-269652-t7ghng17 125 44 35 35 CD cord-269652-t7ghng17 125 45 , , , cord-269652-t7ghng17 125 46 36 36 CD cord-269652-t7ghng17 125 47 and and CC cord-269652-t7ghng17 125 48 prevention prevention NN cord-269652-t7ghng17 125 49 of of IN cord-269652-t7ghng17 125 50 adaptive adaptive JJ cord-269652-t7ghng17 125 51 resistance resistance NN cord-269652-t7ghng17 125 52 . . . cord-269652-t7ghng17 126 1 37 37 CD cord-269652-t7ghng17 126 2 Third third JJ cord-269652-t7ghng17 126 3 - - HYPH cord-269652-t7ghng17 126 4 generation generation NN cord-269652-t7ghng17 126 5 cephalosporins cephalosporin NNS cord-269652-t7ghng17 126 6 should should MD cord-269652-t7ghng17 126 7 be be VB cord-269652-t7ghng17 126 8 used use VBN cord-269652-t7ghng17 126 9 judiciously judiciously RB cord-269652-t7ghng17 126 10 . . . cord-269652-t7ghng17 127 1 There there EX cord-269652-t7ghng17 127 2 is be VBZ cord-269652-t7ghng17 127 3 significant significant JJ cord-269652-t7ghng17 127 4 association association NN cord-269652-t7ghng17 127 5 between between IN cord-269652-t7ghng17 127 6 the the DT cord-269652-t7ghng17 127 7 use use NN cord-269652-t7ghng17 127 8 of of IN cord-269652-t7ghng17 127 9 third third JJ cord-269652-t7ghng17 127 10 - - HYPH cord-269652-t7ghng17 127 11 generation generation NN cord-269652-t7ghng17 127 12 cephalosporins cephalosporin NNS cord-269652-t7ghng17 127 13 and and CC cord-269652-t7ghng17 127 14 invasive invasive JJ cord-269652-t7ghng17 127 15 candidiasis candidiasis NN cord-269652-t7ghng17 127 16 in in IN cord-269652-t7ghng17 127 17 preterm preterm JJ cord-269652-t7ghng17 127 18 infants infant NNS cord-269652-t7ghng17 127 19 . . . cord-269652-t7ghng17 128 1 9 9 CD cord-269652-t7ghng17 129 1 Cefotaxime Cefotaxime NNP cord-269652-t7ghng17 129 2 has have VBZ cord-269652-t7ghng17 129 3 excellent excellent JJ cord-269652-t7ghng17 129 4 penetration penetration NN cord-269652-t7ghng17 129 5 to to IN cord-269652-t7ghng17 129 6 the the DT cord-269652-t7ghng17 129 7 cerebrospinal cerebrospinal JJ cord-269652-t7ghng17 129 8 fluid fluid NN cord-269652-t7ghng17 129 9 and and CC cord-269652-t7ghng17 129 10 its -PRON- PRP$ cord-269652-t7ghng17 129 11 therapeutic therapeutic JJ cord-269652-t7ghng17 129 12 use use NN cord-269652-t7ghng17 129 13 should should MD cord-269652-t7ghng17 129 14 be be VB cord-269652-t7ghng17 129 15 limited limit VBN cord-269652-t7ghng17 129 16 to to IN cord-269652-t7ghng17 129 17 Gram gram NN cord-269652-t7ghng17 129 18 - - HYPH cord-269652-t7ghng17 129 19 negative negative JJ cord-269652-t7ghng17 129 20 meningitis meningitis NN cord-269652-t7ghng17 129 21 . . . cord-269652-t7ghng17 130 1 7 7 LS cord-269652-t7ghng17 130 2 Routine routine JJ cord-269652-t7ghng17 130 3 use use NN cord-269652-t7ghng17 130 4 of of IN cord-269652-t7ghng17 130 5 cefotaxime cefotaxime NN cord-269652-t7ghng17 130 6 for for IN cord-269652-t7ghng17 130 7 EOS EOS NNP cord-269652-t7ghng17 130 8 may may MD cord-269652-t7ghng17 130 9 lead lead VB cord-269652-t7ghng17 130 10 to to IN cord-269652-t7ghng17 130 11 rapid rapid JJ cord-269652-t7ghng17 130 12 development development NN cord-269652-t7ghng17 130 13 of of IN cord-269652-t7ghng17 130 14 drug drug NN cord-269652-t7ghng17 130 15 - - HYPH cord-269652-t7ghng17 130 16 resistant resistant JJ cord-269652-t7ghng17 130 17 organisms organism NNS cord-269652-t7ghng17 130 18 . . . cord-269652-t7ghng17 131 1 38 38 CD cord-269652-t7ghng17 131 2 Ceftriaxone Ceftriaxone NNP cord-269652-t7ghng17 131 3 is be VBZ cord-269652-t7ghng17 131 4 contraindicated contraindicate VBN cord-269652-t7ghng17 131 5 in in IN cord-269652-t7ghng17 131 6 neonates neonate NNS cord-269652-t7ghng17 131 7 for for IN cord-269652-t7ghng17 131 8 2 2 CD cord-269652-t7ghng17 131 9 reasons reason NNS cord-269652-t7ghng17 131 10 : : : cord-269652-t7ghng17 132 1 ( ( -LRB- cord-269652-t7ghng17 132 2 1 1 LS cord-269652-t7ghng17 132 3 ) ) -RRB- cord-269652-t7ghng17 132 4 it -PRON- PRP cord-269652-t7ghng17 132 5 is be VBZ cord-269652-t7ghng17 132 6 highly highly RB cord-269652-t7ghng17 132 7 protein protein NN cord-269652-t7ghng17 132 8 bound bind VBN cord-269652-t7ghng17 132 9 and and CC cord-269652-t7ghng17 132 10 may may MD cord-269652-t7ghng17 132 11 displace displace VB cord-269652-t7ghng17 132 12 bilirubin bilirubin NN cord-269652-t7ghng17 132 13 progressing progress VBG cord-269652-t7ghng17 132 14 to to IN cord-269652-t7ghng17 132 15 hyperbilirubinemia hyperbilirubinemia NN cord-269652-t7ghng17 132 16 7 7 CD cord-269652-t7ghng17 133 1 and and CC cord-269652-t7ghng17 133 2 ( ( -LRB- cord-269652-t7ghng17 133 3 2 2 LS cord-269652-t7ghng17 133 4 ) ) -RRB- cord-269652-t7ghng17 133 5 concurrent concurrent JJ cord-269652-t7ghng17 133 6 administration administration NN cord-269652-t7ghng17 133 7 with with IN cord-269652-t7ghng17 133 8 calcium calcium NN cord-269652-t7ghng17 133 9 - - HYPH cord-269652-t7ghng17 133 10 containing contain VBG cord-269652-t7ghng17 133 11 solutions solution NNS cord-269652-t7ghng17 133 12 may may MD cord-269652-t7ghng17 133 13 produce produce VB cord-269652-t7ghng17 133 14 insoluble insoluble JJ cord-269652-t7ghng17 133 15 precipitates precipitate NNS cord-269652-t7ghng17 133 16 ( ( -LRB- cord-269652-t7ghng17 133 17 ceftriaxone ceftriaxone NN cord-269652-t7ghng17 133 18 - - HYPH cord-269652-t7ghng17 133 19 calcium calcium NN cord-269652-t7ghng17 133 20 salts salt NNS cord-269652-t7ghng17 133 21 ) ) -RRB- cord-269652-t7ghng17 133 22 leading lead VBG cord-269652-t7ghng17 133 23 to to IN cord-269652-t7ghng17 133 24 cardiorespiratory cardiorespiratory JJ cord-269652-t7ghng17 133 25 complications complication NNS cord-269652-t7ghng17 133 26 . . . cord-269652-t7ghng17 134 1 39 39 CD cord-269652-t7ghng17 135 1 The the DT cord-269652-t7ghng17 135 2 AAP AAP NNP cord-269652-t7ghng17 135 3 periodically periodically RB cord-269652-t7ghng17 135 4 updates update VBZ cord-269652-t7ghng17 135 5 the the DT cord-269652-t7ghng17 135 6 dosing dose VBG cord-269652-t7ghng17 135 7 regimens regimen NNS cord-269652-t7ghng17 135 8 and and CC cord-269652-t7ghng17 135 9 recommended recommend VBN cord-269652-t7ghng17 135 10 therapy therapy NN cord-269652-t7ghng17 135 11 for for IN cord-269652-t7ghng17 135 12 selected select VBN cord-269652-t7ghng17 135 13 neonatal neonatal JJ cord-269652-t7ghng17 135 14 infections infection NNS cord-269652-t7ghng17 135 15 through through IN cord-269652-t7ghng17 135 16 Nelson Nelson NNP cord-269652-t7ghng17 135 17 's 's POS cord-269652-t7ghng17 135 18 Pediatric Pediatric NNP cord-269652-t7ghng17 135 19 Antimicrobial Antimicrobial NNP cord-269652-t7ghng17 135 20 Therapy Therapy NNP cord-269652-t7ghng17 135 21 . . . cord-269652-t7ghng17 136 1 32 32 CD cord-269652-t7ghng17 137 1 It -PRON- PRP cord-269652-t7ghng17 137 2 provides provide VBZ cord-269652-t7ghng17 137 3 various various JJ cord-269652-t7ghng17 137 4 antimicrobial antimicrobial JJ cord-269652-t7ghng17 137 5 regimens regimen NNS cord-269652-t7ghng17 137 6 ( ( -LRB- cord-269652-t7ghng17 137 7 antibiotic antibiotic JJ cord-269652-t7ghng17 137 8 , , , cord-269652-t7ghng17 137 9 antiviral antiviral JJ cord-269652-t7ghng17 137 10 , , , cord-269652-t7ghng17 137 11 and and CC cord-269652-t7ghng17 137 12 antifungal antifungal JJ cord-269652-t7ghng17 137 13 agents agent NNS cord-269652-t7ghng17 137 14 ) ) -RRB- cord-269652-t7ghng17 137 15 based base VBN cord-269652-t7ghng17 137 16 on on IN cord-269652-t7ghng17 137 17 body body NN cord-269652-t7ghng17 137 18 weight weight NN cord-269652-t7ghng17 137 19 of of IN cord-269652-t7ghng17 137 20 infants infant NNS cord-269652-t7ghng17 137 21 and and CC cord-269652-t7ghng17 137 22 their -PRON- PRP$ cord-269652-t7ghng17 137 23 chronologic chronologic NN cord-269652-t7ghng17 137 24 age age NN cord-269652-t7ghng17 137 25 or or CC cord-269652-t7ghng17 137 26 gestational gestational JJ cord-269652-t7ghng17 137 27 and and CC cord-269652-t7ghng17 137 28 postnatal postnatal JJ cord-269652-t7ghng17 137 29 age age NN cord-269652-t7ghng17 137 30 . . . cord-269652-t7ghng17 138 1 Between between IN cord-269652-t7ghng17 138 2 new new JJ cord-269652-t7ghng17 138 3 editions edition NNS cord-269652-t7ghng17 138 4 , , , cord-269652-t7ghng17 138 5 a a DT cord-269652-t7ghng17 138 6 monthly monthly JJ cord-269652-t7ghng17 138 7 update update NN cord-269652-t7ghng17 138 8 of of IN cord-269652-t7ghng17 138 9 short short JJ cord-269652-t7ghng17 138 10 and and CC cord-269652-t7ghng17 138 11 interesting interesting JJ cord-269652-t7ghng17 138 12 reports report NNS cord-269652-t7ghng17 138 13 related relate VBN cord-269652-t7ghng17 138 14 to to IN cord-269652-t7ghng17 138 15 pediatric pediatric JJ cord-269652-t7ghng17 138 16 antimicrobial antimicrobial JJ cord-269652-t7ghng17 138 17 therapy therapy NN cord-269652-t7ghng17 138 18 is be VBZ cord-269652-t7ghng17 138 19 posted post VBN cord-269652-t7ghng17 138 20 at at IN cord-269652-t7ghng17 138 21 www.aap.org/en-us/aap-store/Nelsons/ www.aap.org/en-us/aap-store/Nelsons/ NNP cord-269652-t7ghng17 138 22 Pages Pages NNPS cord-269652-t7ghng17 138 23 / / SYM cord-269652-t7ghng17 138 24 Whats Whats NNPS cord-269652-t7ghng17 138 25 - - HYPH cord-269652-t7ghng17 138 26 New.aspx New.aspx NNS cord-269652-t7ghng17 138 27 . . . cord-269652-t7ghng17 139 1 Suggested suggest VBN cord-269652-t7ghng17 139 2 durations duration NNS cord-269652-t7ghng17 139 3 of of IN cord-269652-t7ghng17 139 4 antibiotic antibiotic JJ cord-269652-t7ghng17 139 5 therapy therapy NN cord-269652-t7ghng17 139 6 for for IN cord-269652-t7ghng17 139 7 EOS EOS NNP cord-269652-t7ghng17 139 8 adapted adapt VBD cord-269652-t7ghng17 139 9 from from IN cord-269652-t7ghng17 139 10 2014 2014 CD cord-269652-t7ghng17 139 11 Nelson Nelson NNP cord-269652-t7ghng17 139 12 's 's POS cord-269652-t7ghng17 139 13 Pediatric Pediatric NNP cord-269652-t7ghng17 139 14 Antimicrobial Antimicrobial NNP cord-269652-t7ghng17 139 15 Therapy Therapy NNP cord-269652-t7ghng17 139 16 32 32 CD cord-269652-t7ghng17 139 17 and and CC cord-269652-t7ghng17 139 18 the the DT cord-269652-t7ghng17 139 19 AAP AAP NNP cord-269652-t7ghng17 139 20 Committee Committee NNP cord-269652-t7ghng17 139 21 on on IN cord-269652-t7ghng17 139 22 Fetus Fetus NNP cord-269652-t7ghng17 139 23 and and CC cord-269652-t7ghng17 139 24 Newborn Newborn NNP cord-269652-t7ghng17 139 25 7 7 CD cord-269652-t7ghng17 139 26 are be VBP cord-269652-t7ghng17 139 27 shown show VBN cord-269652-t7ghng17 139 28 in in IN cord-269652-t7ghng17 139 29 Table Table NNP cord-269652-t7ghng17 139 30 2 2 CD cord-269652-t7ghng17 139 31 . . . cord-269652-t7ghng17 140 1 There there EX cord-269652-t7ghng17 140 2 are be VBP cord-269652-t7ghng17 140 3 several several JJ cord-269652-t7ghng17 140 4 antiviral antiviral JJ cord-269652-t7ghng17 140 5 agents agent NNS cord-269652-t7ghng17 140 6 that that WDT cord-269652-t7ghng17 140 7 can can MD cord-269652-t7ghng17 140 8 be be VB cord-269652-t7ghng17 140 9 used use VBN cord-269652-t7ghng17 140 10 for for IN cord-269652-t7ghng17 140 11 the the DT cord-269652-t7ghng17 140 12 treatment treatment NN cord-269652-t7ghng17 140 13 of of IN cord-269652-t7ghng17 140 14 neonatal neonatal JJ cord-269652-t7ghng17 140 15 viral viral JJ cord-269652-t7ghng17 140 16 infections infection NNS cord-269652-t7ghng17 140 17 . . . cord-269652-t7ghng17 141 1 Acyclovir Acyclovir NNP cord-269652-t7ghng17 141 2 ( ( -LRB- cord-269652-t7ghng17 141 3 60 60 CD cord-269652-t7ghng17 141 4 mg mg NNP cord-269652-t7ghng17 141 5 / / SYM cord-269652-t7ghng17 141 6 kg kg NNP cord-269652-t7ghng17 141 7 / / SYM cord-269652-t7ghng17 141 8 d d NN cord-269652-t7ghng17 141 9 IV IV NNP cord-269652-t7ghng17 141 10 divided divide VBD cord-269652-t7ghng17 141 11 every every DT cord-269652-t7ghng17 141 12 8 8 CD cord-269652-t7ghng17 141 13 hours hour NNS cord-269652-t7ghng17 141 14 ) ) -RRB- cord-269652-t7ghng17 141 15 is be VBZ cord-269652-t7ghng17 141 16 the the DT cord-269652-t7ghng17 141 17 treatment treatment NN cord-269652-t7ghng17 141 18 of of IN cord-269652-t7ghng17 141 19 choice choice NN cord-269652-t7ghng17 141 20 for for IN cord-269652-t7ghng17 141 21 term term NN cord-269652-t7ghng17 141 22 infants infant NNS cord-269652-t7ghng17 141 23 with with IN cord-269652-t7ghng17 141 24 herpes herpes NNP cord-269652-t7ghng17 141 25 simplex simplex NNP cord-269652-t7ghng17 141 26 virus virus NN cord-269652-t7ghng17 141 27 ( ( -LRB- cord-269652-t7ghng17 141 28 HSV HSV NNP cord-269652-t7ghng17 141 29 ) ) -RRB- cord-269652-t7ghng17 141 30 and and CC cord-269652-t7ghng17 141 31 varicella varicella NN cord-269652-t7ghng17 141 32 - - HYPH cord-269652-t7ghng17 141 33 zoster zoster NN cord-269652-t7ghng17 141 34 infections infection NNS cord-269652-t7ghng17 141 35 . . . cord-269652-t7ghng17 142 1 32 32 CD cord-269652-t7ghng17 142 2 There there EX cord-269652-t7ghng17 142 3 are be VBP cord-269652-t7ghng17 142 4 several several JJ cord-269652-t7ghng17 142 5 topical topical JJ cord-269652-t7ghng17 142 6 agents agent NNS cord-269652-t7ghng17 142 7 ( ( -LRB- cord-269652-t7ghng17 142 8 0.15 0.15 CD cord-269652-t7ghng17 142 9 % % NN cord-269652-t7ghng17 142 10 ganciclovir ganciclovir NN cord-269652-t7ghng17 142 11 ophthalmic ophthalmic JJ cord-269652-t7ghng17 142 12 gel gel NN cord-269652-t7ghng17 142 13 , , , cord-269652-t7ghng17 142 14 0.1 0.1 CD cord-269652-t7ghng17 142 15 % % NN cord-269652-t7ghng17 142 16 iododeoxyuridine iododeoxyuridine NN cord-269652-t7ghng17 142 17 , , , cord-269652-t7ghng17 142 18 or or CC cord-269652-t7ghng17 142 19 1 1 CD cord-269652-t7ghng17 142 20 % % NN cord-269652-t7ghng17 142 21 trifluridine trifluridine NN cord-269652-t7ghng17 142 22 ) ) -RRB- cord-269652-t7ghng17 142 23 that that WDT cord-269652-t7ghng17 142 24 may may MD cord-269652-t7ghng17 142 25 be be VB cord-269652-t7ghng17 142 26 added add VBN cord-269652-t7ghng17 142 27 to to IN cord-269652-t7ghng17 142 28 systemic systemic JJ cord-269652-t7ghng17 142 29 antiviral antiviral JJ cord-269652-t7ghng17 142 30 regimen regimen NN cord-269652-t7ghng17 142 31 if if IN cord-269652-t7ghng17 142 32 there there EX cord-269652-t7ghng17 142 33 is be VBZ cord-269652-t7ghng17 142 34 eye eye NN cord-269652-t7ghng17 142 35 involvement involvement NN cord-269652-t7ghng17 142 36 . . . cord-269652-t7ghng17 143 1 32 32 CD cord-269652-t7ghng17 144 1 After after IN cord-269652-t7ghng17 144 2 parenteral parenteral JJ cord-269652-t7ghng17 144 3 therapy therapy NN cord-269652-t7ghng17 144 4 with with IN cord-269652-t7ghng17 144 5 acyclovir acyclovir NNP cord-269652-t7ghng17 144 6 , , , cord-269652-t7ghng17 144 7 it -PRON- PRP cord-269652-t7ghng17 144 8 is be VBZ cord-269652-t7ghng17 144 9 recommended recommend VBN cord-269652-t7ghng17 144 10 to to TO cord-269652-t7ghng17 144 11 give give VB cord-269652-t7ghng17 144 12 HSV HSV NNP cord-269652-t7ghng17 144 13 suppressive suppressive JJ cord-269652-t7ghng17 144 14 regimen regimen NN cord-269652-t7ghng17 144 15 ( ( -LRB- cord-269652-t7ghng17 144 16 300 300 CD cord-269652-t7ghng17 144 17 mg mg NNP cord-269652-t7ghng17 144 18 / / SYM cord-269652-t7ghng17 144 19 m m NN cord-269652-t7ghng17 144 20 2 2 CD cord-269652-t7ghng17 144 21 /dose /dose . cord-269652-t7ghng17 144 22 po po NNP cord-269652-t7ghng17 144 23 tid tid NNP cord-269652-t7ghng17 144 24 ) ) -RRB- cord-269652-t7ghng17 144 25 , , , cord-269652-t7ghng17 144 26 which which WDT cord-269652-t7ghng17 144 27 improves improve VBZ cord-269652-t7ghng17 144 28 neurodevelopmental neurodevelopmental JJ cord-269652-t7ghng17 144 29 outcomes outcome NNS cord-269652-t7ghng17 144 30 of of IN cord-269652-t7ghng17 144 31 infants infant NNS cord-269652-t7ghng17 144 32 with with IN cord-269652-t7ghng17 144 33 central central JJ cord-269652-t7ghng17 144 34 nervous nervous JJ cord-269652-t7ghng17 144 35 system system NN cord-269652-t7ghng17 144 36 involvement involvement NN cord-269652-t7ghng17 144 37 . . . cord-269652-t7ghng17 145 1 40 40 CD cord-269652-t7ghng17 146 1 There there EX cord-269652-t7ghng17 146 2 is be VBZ cord-269652-t7ghng17 146 3 currently currently RB cord-269652-t7ghng17 146 4 no no DT cord-269652-t7ghng17 146 5 dosing dose VBG cord-269652-t7ghng17 146 6 regimen regimen NN cord-269652-t7ghng17 146 7 for for IN cord-269652-t7ghng17 146 8 valacyclovir valacyclovir NNP cord-269652-t7ghng17 146 9 in in IN cord-269652-t7ghng17 146 10 infants infant NNS cord-269652-t7ghng17 146 11 younger young JJR cord-269652-t7ghng17 146 12 than than IN cord-269652-t7ghng17 146 13 3 3 CD cord-269652-t7ghng17 146 14 months month NNS cord-269652-t7ghng17 146 15 of of IN cord-269652-t7ghng17 146 16 age age NN cord-269652-t7ghng17 146 17 . . . cord-269652-t7ghng17 147 1 32 32 CD cord-269652-t7ghng17 148 1 The the DT cord-269652-t7ghng17 148 2 AAP AAP NNP cord-269652-t7ghng17 148 3 Committee Committee NNP cord-269652-t7ghng17 148 4 on on IN cord-269652-t7ghng17 148 5 Infectious Infectious NNP cord-269652-t7ghng17 148 6 Diseases Diseases NNPS cord-269652-t7ghng17 148 7 and and CC cord-269652-t7ghng17 148 8 the the DT cord-269652-t7ghng17 148 9 Committee Committee NNP cord-269652-t7ghng17 148 10 on on IN cord-269652-t7ghng17 148 11 Fetus Fetus NNP cord-269652-t7ghng17 148 12 and and CC cord-269652-t7ghng17 148 13 Newborn Newborn NNP cord-269652-t7ghng17 148 14 recently recently RB cord-269652-t7ghng17 148 15 published publish VBD cord-269652-t7ghng17 148 16 an an DT cord-269652-t7ghng17 148 17 algorithm algorithm NN cord-269652-t7ghng17 148 18 - - HYPH cord-269652-t7ghng17 148 19 based base VBN cord-269652-t7ghng17 148 20 guideline guideline NN cord-269652-t7ghng17 148 21 on on IN cord-269652-t7ghng17 148 22 the the DT cord-269652-t7ghng17 148 23 evaluation evaluation NN cord-269652-t7ghng17 148 24 and and CC cord-269652-t7ghng17 148 25 treatment treatment NN cord-269652-t7ghng17 148 26 of of IN cord-269652-t7ghng17 148 27 asymptomatic asymptomatic JJ cord-269652-t7ghng17 148 28 infants infant NNS cord-269652-t7ghng17 148 29 born bear VBN cord-269652-t7ghng17 148 30 to to IN cord-269652-t7ghng17 148 31 mothers mother NNS cord-269652-t7ghng17 148 32 with with IN cord-269652-t7ghng17 148 33 active active JJ cord-269652-t7ghng17 148 34 herpes herpes NN cord-269652-t7ghng17 148 35 lesions lesion NNS cord-269652-t7ghng17 148 36 41 41 CD cord-269652-t7ghng17 148 37 ( ( -LRB- cord-269652-t7ghng17 148 38 http:// http:// NNP cord-269652-t7ghng17 148 39 www.ncbi.nlm.nih.gov/pubmed/23359576 www.ncbi.nlm.nih.gov/pubmed/23359576 NNP cord-269652-t7ghng17 148 40 ) ) -RRB- cord-269652-t7ghng17 148 41 . . . cord-269652-t7ghng17 149 1 Oral oral JJ cord-269652-t7ghng17 149 2 valganciclovir valganciclovir NNS cord-269652-t7ghng17 149 3 ( ( -LRB- cord-269652-t7ghng17 149 4 16 16 CD cord-269652-t7ghng17 149 5 mg mg NNP cord-269652-t7ghng17 149 6 / / SYM cord-269652-t7ghng17 149 7 kg kg NN cord-269652-t7ghng17 149 8 / / SYM cord-269652-t7ghng17 149 9 dose dose NN cord-269652-t7ghng17 149 10 po po NNP cord-269652-t7ghng17 149 11 bid bid NN cord-269652-t7ghng17 149 12 ) ) -RRB- cord-269652-t7ghng17 149 13 is be VBZ cord-269652-t7ghng17 149 14 the the DT cord-269652-t7ghng17 149 15 drug drug NN cord-269652-t7ghng17 149 16 of of IN cord-269652-t7ghng17 149 17 choice choice NN cord-269652-t7ghng17 149 18 for for IN cord-269652-t7ghng17 149 19 infants infant NNS cord-269652-t7ghng17 149 20 with with IN cord-269652-t7ghng17 149 21 symptomatic symptomatic JJ cord-269652-t7ghng17 149 22 congenital congenital JJ cord-269652-t7ghng17 149 23 cytomegalovirus cytomegalovirus NN cord-269652-t7ghng17 149 24 ( ( -LRB- cord-269652-t7ghng17 149 25 CMV CMV NNP cord-269652-t7ghng17 149 26 ) ) -RRB- cord-269652-t7ghng17 149 27 disease disease NN cord-269652-t7ghng17 149 28 with with IN cord-269652-t7ghng17 149 29 or or CC cord-269652-t7ghng17 149 30 without without IN cord-269652-t7ghng17 149 31 central central JJ cord-269652-t7ghng17 149 32 nervous nervous JJ cord-269652-t7ghng17 149 33 system system NN cord-269652-t7ghng17 149 34 involvement involvement NN cord-269652-t7ghng17 149 35 . . . cord-269652-t7ghng17 150 1 32 32 CD cord-269652-t7ghng17 150 2 , , , cord-269652-t7ghng17 150 3 42 42 CD cord-269652-t7ghng17 151 1 The the DT cord-269652-t7ghng17 151 2 treatment treatment NN cord-269652-t7ghng17 151 3 of of IN cord-269652-t7ghng17 151 4 congenital congenital JJ cord-269652-t7ghng17 151 5 CMV CMV NNP cord-269652-t7ghng17 151 6 should should MD cord-269652-t7ghng17 151 7 be be VB cord-269652-t7ghng17 151 8 initiated initiate VBN cord-269652-t7ghng17 151 9 in in IN cord-269652-t7ghng17 151 10 the the DT cord-269652-t7ghng17 151 11 first first JJ cord-269652-t7ghng17 151 12 month month NN cord-269652-t7ghng17 151 13 of of IN cord-269652-t7ghng17 151 14 life life NN cord-269652-t7ghng17 151 15 . . . cord-269652-t7ghng17 152 1 Kimberlin Kimberlin NNP cord-269652-t7ghng17 152 2 and and CC cord-269652-t7ghng17 152 3 colleagues colleague NNS cord-269652-t7ghng17 152 4 42 42 CD cord-269652-t7ghng17 152 5 concluded conclude VBD cord-269652-t7ghng17 152 6 from from IN cord-269652-t7ghng17 152 7 the the DT cord-269652-t7ghng17 152 8 phase phase NN cord-269652-t7ghng17 152 9 III iii CD cord-269652-t7ghng17 152 10 randomized randomized JJ cord-269652-t7ghng17 152 11 double double JJ cord-269652-t7ghng17 152 12 - - HYPH cord-269652-t7ghng17 152 13 blind blind JJ cord-269652-t7ghng17 152 14 placebo placebo NN cord-269652-t7ghng17 152 15 - - HYPH cord-269652-t7ghng17 152 16 controlled control VBN cord-269652-t7ghng17 152 17 multinational multinational JJ cord-269652-t7ghng17 152 18 study study NN cord-269652-t7ghng17 152 19 that that IN cord-269652-t7ghng17 152 20 6 6 CD cord-269652-t7ghng17 152 21 months month NNS cord-269652-t7ghng17 152 22 of of IN cord-269652-t7ghng17 152 23 valganciclovir valganciclovir JJ cord-269652-t7ghng17 152 24 regimen regimen NN cord-269652-t7ghng17 152 25 for for IN cord-269652-t7ghng17 152 26 symptomatic symptomatic JJ cord-269652-t7ghng17 152 27 congenital congenital JJ cord-269652-t7ghng17 152 28 CMV CMV NNP cord-269652-t7ghng17 152 29 disease disease NN cord-269652-t7ghng17 152 30 significantly significantly RB cord-269652-t7ghng17 152 31 improves improve VBZ cord-269652-t7ghng17 152 32 hearing hear VBG cord-269652-t7ghng17 152 33 and and CC cord-269652-t7ghng17 152 34 neurodevelopmental neurodevelopmental JJ cord-269652-t7ghng17 152 35 outcomes outcome NNS cord-269652-t7ghng17 152 36 . . . cord-269652-t7ghng17 153 1 There there EX cord-269652-t7ghng17 153 2 is be VBZ cord-269652-t7ghng17 153 3 significant significant JJ cord-269652-t7ghng17 153 4 improvement improvement NN cord-269652-t7ghng17 153 5 in in IN cord-269652-t7ghng17 153 6 language language NN cord-269652-t7ghng17 153 7 and and CC cord-269652-t7ghng17 153 8 receptive receptive JJ cord-269652-t7ghng17 153 9 communication communication NN cord-269652-t7ghng17 153 10 at at IN cord-269652-t7ghng17 153 11 2 2 CD cord-269652-t7ghng17 153 12 years year NNS cord-269652-t7ghng17 153 13 of of IN cord-269652-t7ghng17 153 14 age age NN cord-269652-t7ghng17 153 15 . . . cord-269652-t7ghng17 154 1 There there EX cord-269652-t7ghng17 154 2 was be VBD cord-269652-t7ghng17 154 3 less less JJR cord-269652-t7ghng17 154 4 grade grade NN cord-269652-t7ghng17 154 5 3 3 CD cord-269652-t7ghng17 154 6 to to IN cord-269652-t7ghng17 154 7 4 4 CD cord-269652-t7ghng17 154 8 neutropenia neutropenia NN cord-269652-t7ghng17 154 9 at at IN cord-269652-t7ghng17 154 10 6 6 CD cord-269652-t7ghng17 154 11 weeks week NNS cord-269652-t7ghng17 154 12 oral oral JJ cord-269652-t7ghng17 154 13 valganciclovir valganciclovir NNS cord-269652-t7ghng17 154 14 ( ( -LRB- cord-269652-t7ghng17 154 15 w19 w19 CD cord-269652-t7ghng17 154 16 % % NN cord-269652-t7ghng17 154 17 ) ) -RRB- cord-269652-t7ghng17 154 18 compared compare VBN cord-269652-t7ghng17 154 19 with with IN cord-269652-t7ghng17 154 20 6 6 CD cord-269652-t7ghng17 154 21 weeks week NNS cord-269652-t7ghng17 154 22 of of IN cord-269652-t7ghng17 154 23 IV IV NNP cord-269652-t7ghng17 154 24 ganciclovir ganciclovir NNP cord-269652-t7ghng17 154 25 ( ( -LRB- cord-269652-t7ghng17 154 26 63 63 CD cord-269652-t7ghng17 154 27 % % NN cord-269652-t7ghng17 154 28 ) ) -RRB- cord-269652-t7ghng17 154 29 reported report VBD cord-269652-t7ghng17 154 30 previously previously RB cord-269652-t7ghng17 154 31 . . . cord-269652-t7ghng17 155 1 IV IV NNP cord-269652-t7ghng17 155 2 ganciclovir ganciclovir NNP cord-269652-t7ghng17 155 3 ( ( -LRB- cord-269652-t7ghng17 155 4 6 6 CD cord-269652-t7ghng17 155 5 mg mg NNP cord-269652-t7ghng17 155 6 / / SYM cord-269652-t7ghng17 155 7 kg kg NN cord-269652-t7ghng17 155 8 / / SYM cord-269652-t7ghng17 155 9 dose dose NN cord-269652-t7ghng17 155 10 bid bid NN cord-269652-t7ghng17 155 11 ) ) -RRB- cord-269652-t7ghng17 155 12 can can MD cord-269652-t7ghng17 155 13 be be VB cord-269652-t7ghng17 155 14 used use VBN cord-269652-t7ghng17 155 15 initially initially RB cord-269652-t7ghng17 155 16 for for IN cord-269652-t7ghng17 155 17 infants infant NNS cord-269652-t7ghng17 155 18 with with IN cord-269652-t7ghng17 155 19 symptomatic symptomatic JJ cord-269652-t7ghng17 155 20 congenital congenital JJ cord-269652-t7ghng17 155 21 CMV CMV NNP cord-269652-t7ghng17 155 22 disease disease NN cord-269652-t7ghng17 155 23 if if IN cord-269652-t7ghng17 155 24 oral oral JJ cord-269652-t7ghng17 155 25 valganciclovir valganciclovir NNP cord-269652-t7ghng17 155 26 is be VBZ cord-269652-t7ghng17 155 27 contraindicated contraindicate VBN cord-269652-t7ghng17 155 28 due due IN cord-269652-t7ghng17 155 29 to to IN cord-269652-t7ghng17 155 30 extreme extreme JJ cord-269652-t7ghng17 155 31 prematurity prematurity NN cord-269652-t7ghng17 155 32 or or CC cord-269652-t7ghng17 155 33 NEC NEC NNP cord-269652-t7ghng17 155 34 . . . cord-269652-t7ghng17 156 1 32 32 CD cord-269652-t7ghng17 157 1 The the DT cord-269652-t7ghng17 157 2 same same JJ cord-269652-t7ghng17 157 3 dosing dosing NN cord-269652-t7ghng17 157 4 regimen regimen NN cord-269652-t7ghng17 157 5 is be VBZ cord-269652-t7ghng17 157 6 the the DT cord-269652-t7ghng17 157 7 treatment treatment NN cord-269652-t7ghng17 157 8 of of IN cord-269652-t7ghng17 157 9 choice choice NN cord-269652-t7ghng17 157 10 for for IN cord-269652-t7ghng17 157 11 perinatally perinatally RB cord-269652-t7ghng17 157 12 or or CC cord-269652-t7ghng17 157 13 postnatally postnatally RB cord-269652-t7ghng17 157 14 acquired acquire VBD cord-269652-t7ghng17 157 15 CMV CMV NNP cord-269652-t7ghng17 157 16 disease disease NN cord-269652-t7ghng17 157 17 associated associate VBN cord-269652-t7ghng17 157 18 encephalitis encephalitis RB cord-269652-t7ghng17 157 19 , , , cord-269652-t7ghng17 157 20 hepatitis hepatitis NN cord-269652-t7ghng17 157 21 , , , cord-269652-t7ghng17 157 22 pneumonitis pneumonitis NN cord-269652-t7ghng17 157 23 , , , cord-269652-t7ghng17 157 24 or or CC cord-269652-t7ghng17 157 25 persistent persistent JJ cord-269652-t7ghng17 157 26 thrombocytopenia thrombocytopenia NN cord-269652-t7ghng17 157 27 . . . cord-269652-t7ghng17 158 1 Oral oral JJ cord-269652-t7ghng17 158 2 oseltamivir oseltamivir NNS cord-269652-t7ghng17 158 3 ( ( -LRB- cord-269652-t7ghng17 158 4 3 3 CD cord-269652-t7ghng17 158 5 mg mg NNP cord-269652-t7ghng17 158 6 / / SYM cord-269652-t7ghng17 158 7 kg kg NN cord-269652-t7ghng17 158 8 / / SYM cord-269652-t7ghng17 158 9 dose dose NN cord-269652-t7ghng17 158 10 bid bid NN cord-269652-t7ghng17 158 11 ) ) -RRB- cord-269652-t7ghng17 158 12 remains remain VBZ cord-269652-t7ghng17 158 13 the the DT cord-269652-t7ghng17 158 14 treatment treatment NN cord-269652-t7ghng17 158 15 of of IN cord-269652-t7ghng17 158 16 choice choice NN cord-269652-t7ghng17 158 17 for for IN cord-269652-t7ghng17 158 18 term term NN cord-269652-t7ghng17 158 19 infants infant NNS cord-269652-t7ghng17 158 20 with with IN cord-269652-t7ghng17 158 21 influenza influenza NN cord-269652-t7ghng17 158 22 infections infection NNS cord-269652-t7ghng17 158 23 . . . cord-269652-t7ghng17 159 1 32 32 CD cord-269652-t7ghng17 159 2 , , , cord-269652-t7ghng17 159 3 43 43 CD cord-269652-t7ghng17 159 4 Oral oral JJ cord-269652-t7ghng17 159 5 suspension suspension NN cord-269652-t7ghng17 159 6 formulation formulation NN cord-269652-t7ghng17 159 7 is be VBZ cord-269652-t7ghng17 159 8 available available JJ cord-269652-t7ghng17 159 9 ( ( -LRB- cord-269652-t7ghng17 159 10 6 6 CD cord-269652-t7ghng17 159 11 mg mg NN cord-269652-t7ghng17 159 12 / / SYM cord-269652-t7ghng17 159 13 mL mL NNP cord-269652-t7ghng17 159 14 ) ) -RRB- cord-269652-t7ghng17 159 15 and and CC cord-269652-t7ghng17 159 16 should should MD cord-269652-t7ghng17 159 17 be be VB cord-269652-t7ghng17 159 18 offered offer VBN cord-269652-t7ghng17 159 19 to to IN cord-269652-t7ghng17 159 20 young young JJ cord-269652-t7ghng17 159 21 infants infant NNS cord-269652-t7ghng17 159 22 with with IN cord-269652-t7ghng17 159 23 suspected suspect VBN cord-269652-t7ghng17 159 24 or or CC cord-269652-t7ghng17 159 25 confirmed confirm VBN cord-269652-t7ghng17 159 26 influenza influenza NN cord-269652-t7ghng17 159 27 infection infection NN cord-269652-t7ghng17 159 28 regardless regardless RB cord-269652-t7ghng17 159 29 of of IN cord-269652-t7ghng17 159 30 severity severity NN cord-269652-t7ghng17 159 31 because because IN cord-269652-t7ghng17 159 32 they -PRON- PRP cord-269652-t7ghng17 159 33 are be VBP cord-269652-t7ghng17 159 34 at at IN cord-269652-t7ghng17 159 35 higher high JJR cord-269652-t7ghng17 159 36 risk risk NN cord-269652-t7ghng17 159 37 for for IN cord-269652-t7ghng17 159 38 complications complication NNS cord-269652-t7ghng17 159 39 . . . cord-269652-t7ghng17 160 1 43 43 CD cord-269652-t7ghng17 160 2 Limited limited JJ cord-269652-t7ghng17 160 3 data datum NNS cord-269652-t7ghng17 160 4 are be VBP cord-269652-t7ghng17 160 5 available available JJ cord-269652-t7ghng17 160 6 for for IN cord-269652-t7ghng17 160 7 the the DT cord-269652-t7ghng17 160 8 weight weight NN cord-269652-t7ghng17 160 9 - - HYPH cord-269652-t7ghng17 160 10 based base VBN cord-269652-t7ghng17 160 11 dosing dosing NN cord-269652-t7ghng17 160 12 regimen regimen NN cord-269652-t7ghng17 160 13 for for IN cord-269652-t7ghng17 160 14 preterm preterm JJ cord-269652-t7ghng17 160 15 infants infant NNS cord-269652-t7ghng17 160 16 using use VBG cord-269652-t7ghng17 160 17 postmenstrual postmenstrual JJ cord-269652-t7ghng17 160 18 age age NN cord-269652-t7ghng17 160 19 ( ( -LRB- cord-269652-t7ghng17 160 20 ie ie FW cord-269652-t7ghng17 160 21 , , , cord-269652-t7ghng17 160 22 gestational gestational JJ cord-269652-t7ghng17 160 23 age age NN cord-269652-t7ghng17 160 24 plus plus CC cord-269652-t7ghng17 160 25 chronologic chronologic NN cord-269652-t7ghng17 160 26 age age NN cord-269652-t7ghng17 160 27 ) ) -RRB- cord-269652-t7ghng17 160 28 : : : cord-269652-t7ghng17 160 29 Less Less JJR cord-269652-t7ghng17 160 30 than than IN cord-269652-t7ghng17 160 31 38 38 CD cord-269652-t7ghng17 160 32 weeks week NNS cord-269652-t7ghng17 160 33 postmenstrual postmenstrual JJ cord-269652-t7ghng17 160 34 age age NN cord-269652-t7ghng17 160 35 , , , cord-269652-t7ghng17 160 36 1 1 CD cord-269652-t7ghng17 160 37 mg mg NNP cord-269652-t7ghng17 160 38 / / SYM cord-269652-t7ghng17 160 39 kg kg NNP cord-269652-t7ghng17 161 1 /dose /dose . cord-269652-t7ghng17 161 2 po po NNP cord-269652-t7ghng17 161 3 bid bid VBD cord-269652-t7ghng17 161 4 38 38 CD cord-269652-t7ghng17 161 5 to to TO cord-269652-t7ghng17 161 6 40 40 CD cord-269652-t7ghng17 161 7 weeks week NNS cord-269652-t7ghng17 161 8 , , , cord-269652-t7ghng17 161 9 1.5 1.5 CD cord-269652-t7ghng17 161 10 mg mg NN cord-269652-t7ghng17 161 11 / / SYM cord-269652-t7ghng17 161 12 kg kg NNP cord-269652-t7ghng17 162 1 /dose /dose . cord-269652-t7ghng17 163 1 po po NNP cord-269652-t7ghng17 163 2 bid bid VBD cord-269652-t7ghng17 163 3 Greater great JJR cord-269652-t7ghng17 163 4 than than IN cord-269652-t7ghng17 163 5 40 40 CD cord-269652-t7ghng17 163 6 weeks week NNS cord-269652-t7ghng17 163 7 , , , cord-269652-t7ghng17 163 8 3 3 CD cord-269652-t7ghng17 163 9 mg mg NN cord-269652-t7ghng17 163 10 / / SYM cord-269652-t7ghng17 163 11 kg kg NNP cord-269652-t7ghng17 164 1 /dose /dose . cord-269652-t7ghng17 164 2 po po NNP cord-269652-t7ghng17 164 3 bid bid NNP cord-269652-t7ghng17 164 4 . . . cord-269652-t7ghng17 165 1 There there EX cord-269652-t7ghng17 165 2 is be VBZ cord-269652-t7ghng17 165 3 currently currently RB cord-269652-t7ghng17 165 4 no no DT cord-269652-t7ghng17 165 5 dosing dose VBG cord-269652-t7ghng17 165 6 regimen regimen NN cord-269652-t7ghng17 165 7 for for IN cord-269652-t7ghng17 165 8 inhalational inhalational NNP cord-269652-t7ghng17 165 9 zanamivir zanamivir NNP cord-269652-t7ghng17 165 10 for for IN cord-269652-t7ghng17 165 11 young young JJ cord-269652-t7ghng17 165 12 infants infant NNS cord-269652-t7ghng17 165 13 . . . cord-269652-t7ghng17 166 1 Suggested suggest VBN cord-269652-t7ghng17 166 2 durations duration NNS cord-269652-t7ghng17 166 3 of of IN cord-269652-t7ghng17 166 4 antiviral antiviral JJ cord-269652-t7ghng17 166 5 therapy therapy NN cord-269652-t7ghng17 166 6 , , , cord-269652-t7ghng17 166 7 prophylaxis prophylaxis NN cord-269652-t7ghng17 166 8 , , , cord-269652-t7ghng17 166 9 and and CC cord-269652-t7ghng17 166 10 suppressive suppressive JJ cord-269652-t7ghng17 166 11 regimen regimen NN cord-269652-t7ghng17 166 12 for for IN cord-269652-t7ghng17 166 13 congenital congenital JJ cord-269652-t7ghng17 166 14 and and CC cord-269652-t7ghng17 166 15 perinatal perinatal JJ cord-269652-t7ghng17 166 16 or or CC cord-269652-t7ghng17 166 17 postnatally postnatally RB cord-269652-t7ghng17 166 18 acquired acquire VBN cord-269652-t7ghng17 166 19 viral viral JJ cord-269652-t7ghng17 166 20 infections infection NNS cord-269652-t7ghng17 166 21 adapted adapt VBN cord-269652-t7ghng17 166 22 from from IN cord-269652-t7ghng17 166 23 2014 2014 CD cord-269652-t7ghng17 166 24 Nelson Nelson NNP cord-269652-t7ghng17 166 25 's 's POS cord-269652-t7ghng17 166 26 Pediatric Pediatric NNP cord-269652-t7ghng17 166 27 Antimicrobial Antimicrobial NNP cord-269652-t7ghng17 166 28 Therapy Therapy NNP cord-269652-t7ghng17 166 29 32 32 CD cord-269652-t7ghng17 166 30 and and CC cord-269652-t7ghng17 166 31 the the DT cord-269652-t7ghng17 166 32 AAP AAP NNP cord-269652-t7ghng17 166 33 Committee Committee NNP cord-269652-t7ghng17 166 34 on on IN cord-269652-t7ghng17 166 35 Infectious Infectious NNP cord-269652-t7ghng17 166 36 Diseases Diseases NNPS cord-269652-t7ghng17 166 37 and and CC cord-269652-t7ghng17 166 38 the the DT cord-269652-t7ghng17 166 39 Committee Committee NNP cord-269652-t7ghng17 166 40 on on IN cord-269652-t7ghng17 166 41 Fetus Fetus NNP cord-269652-t7ghng17 166 42 and and CC cord-269652-t7ghng17 166 43 Newborn Newborn NNP cord-269652-t7ghng17 166 44 41 41 CD cord-269652-t7ghng17 166 45 are be VBP cord-269652-t7ghng17 166 46 shown show VBN cord-269652-t7ghng17 166 47 in in IN cord-269652-t7ghng17 166 48 Table Table NNP cord-269652-t7ghng17 166 49 3 3 CD cord-269652-t7ghng17 166 50 . . . cord-269652-t7ghng17 167 1 Fig Fig NNP cord-269652-t7ghng17 167 2 . . NNP cord-269652-t7ghng17 167 3 2 2 CD cord-269652-t7ghng17 167 4 shows show VBZ cord-269652-t7ghng17 167 5 an an DT cord-269652-t7ghng17 167 6 extensive extensive JJ cord-269652-t7ghng17 167 7 cutaneous cutaneous JJ cord-269652-t7ghng17 167 8 aspergillosis aspergillosis NN cord-269652-t7ghng17 167 9 on on IN cord-269652-t7ghng17 167 10 a a DT cord-269652-t7ghng17 167 11 preterm preterm JJ cord-269652-t7ghng17 167 12 infant infant NN cord-269652-t7ghng17 167 13 who who WP cord-269652-t7ghng17 167 14 was be VBD cord-269652-t7ghng17 167 15 a a DT cord-269652-t7ghng17 167 16 poor poor JJ cord-269652-t7ghng17 167 17 surgical surgical JJ cord-269652-t7ghng17 167 18 risk risk NN cord-269652-t7ghng17 167 19 successfully successfully RB cord-269652-t7ghng17 167 20 treated treat VBN cord-269652-t7ghng17 167 21 with with IN cord-269652-t7ghng17 167 22 combination combination NN cord-269652-t7ghng17 167 23 antifungal antifungal NN cord-269652-t7ghng17 167 24 agents agent NNS cord-269652-t7ghng17 167 25 . . . cord-269652-t7ghng17 168 1 Fluconazole fluconazole NN cord-269652-t7ghng17 168 2 prophylaxis prophylaxis NN cord-269652-t7ghng17 168 3 ( ( -LRB- cord-269652-t7ghng17 168 4 6 6 CD cord-269652-t7ghng17 168 5 mg mg NNP cord-269652-t7ghng17 168 6 / / SYM cord-269652-t7ghng17 168 7 kg kg NNP cord-269652-t7ghng17 168 8 / / SYM cord-269652-t7ghng17 168 9 d d XX cord-269652-t7ghng17 168 10 twice twice PDT cord-269652-t7ghng17 168 11 a a DT cord-269652-t7ghng17 168 12 week week NN cord-269652-t7ghng17 168 13 ) ) -RRB- cord-269652-t7ghng17 168 14 may may MD cord-269652-t7ghng17 168 15 be be VB cord-269652-t7ghng17 168 16 indicated indicate VBN cord-269652-t7ghng17 168 17 in in IN cord-269652-t7ghng17 168 18 high high JJ cord-269652-t7ghng17 168 19 - - HYPH cord-269652-t7ghng17 168 20 risk risk NN cord-269652-t7ghng17 168 21 infants infant NNS cord-269652-t7ghng17 168 22 with with IN cord-269652-t7ghng17 168 23 birth birth NN cord-269652-t7ghng17 168 24 weight weight NN cord-269652-t7ghng17 168 25 of of IN cord-269652-t7ghng17 168 26 less less JJR cord-269652-t7ghng17 168 27 than than IN cord-269652-t7ghng17 168 28 1000 1000 CD cord-269652-t7ghng17 168 29 g g NN cord-269652-t7ghng17 168 30 from from IN cord-269652-t7ghng17 168 31 institutions institution NNS cord-269652-t7ghng17 168 32 with with IN cord-269652-t7ghng17 168 33 high high JJ cord-269652-t7ghng17 168 34 incidence incidence NN cord-269652-t7ghng17 168 35 of of IN cord-269652-t7ghng17 168 36 candidiasis candidiasis NN cord-269652-t7ghng17 168 37 ( ( -LRB- cord-269652-t7ghng17 168 38 ie ie FW cord-269652-t7ghng17 168 39 , , , cord-269652-t7ghng17 168 40 above above IN cord-269652-t7ghng17 168 41 10 10 CD cord-269652-t7ghng17 168 42 % % NN cord-269652-t7ghng17 168 43 ) ) -RRB- cord-269652-t7ghng17 168 44 . . . cord-269652-t7ghng17 169 1 32 32 CD cord-269652-t7ghng17 169 2 Fluconazole Fluconazole NNP cord-269652-t7ghng17 169 3 prophylaxis prophylaxis NN cord-269652-t7ghng17 169 4 ( ( -LRB- cord-269652-t7ghng17 169 5 25 25 CD cord-269652-t7ghng17 169 6 mg mg NNP cord-269652-t7ghng17 169 7 / / SYM cord-269652-t7ghng17 169 8 kg kg NNP cord-269652-t7ghng17 169 9 once once RB cord-269652-t7ghng17 169 10 weekly weekly JJ cord-269652-t7ghng17 169 11 ) ) -RRB- cord-269652-t7ghng17 169 12 may may MD cord-269652-t7ghng17 169 13 be be VB cord-269652-t7ghng17 169 14 offered offer VBN cord-269652-t7ghng17 169 15 to to IN cord-269652-t7ghng17 169 16 young young JJ cord-269652-t7ghng17 169 17 infants infant NNS cord-269652-t7ghng17 169 18 younger young JJR cord-269652-t7ghng17 169 19 than than IN cord-269652-t7ghng17 169 20 4 4 CD cord-269652-t7ghng17 169 21 months month NNS cord-269652-t7ghng17 169 22 old old JJ cord-269652-t7ghng17 169 23 on on IN cord-269652-t7ghng17 169 24 extracorporeal extracorporeal JJ cord-269652-t7ghng17 169 25 membrane membrane NN cord-269652-t7ghng17 169 26 oxygenation oxygenation NN cord-269652-t7ghng17 169 27 . . . cord-269652-t7ghng17 170 1 Suggested suggest VBN cord-269652-t7ghng17 170 2 durations duration NNS cord-269652-t7ghng17 170 3 of of IN cord-269652-t7ghng17 170 4 antifungal antifungal JJ cord-269652-t7ghng17 170 5 treatment treatment NN cord-269652-t7ghng17 170 6 of of IN cord-269652-t7ghng17 170 7 candidiasis candidiasis NN cord-269652-t7ghng17 170 8 and and CC cord-269652-t7ghng17 170 9 aspergillosis aspergillosis NN cord-269652-t7ghng17 170 10 adapted adapt VBN cord-269652-t7ghng17 170 11 from from IN cord-269652-t7ghng17 170 12 2014 2014 CD cord-269652-t7ghng17 170 13 Nelson Nelson NNP cord-269652-t7ghng17 170 14 's 's POS cord-269652-t7ghng17 170 15 Pediatric Pediatric NNP cord-269652-t7ghng17 170 16 Antimicrobial Antimicrobial NNP cord-269652-t7ghng17 170 17 Therapy Therapy NNP cord-269652-t7ghng17 170 18 32 32 CD cord-269652-t7ghng17 170 19 are be VBP cord-269652-t7ghng17 170 20 shown show VBN cord-269652-t7ghng17 170 21 in in IN cord-269652-t7ghng17 170 22 Table Table NNP cord-269652-t7ghng17 170 23 4 4 CD cord-269652-t7ghng17 170 24 . . . cord-269652-t7ghng17 171 1 Surgical surgical JJ cord-269652-t7ghng17 171 2 interventions intervention NNS cord-269652-t7ghng17 171 3 may may MD cord-269652-t7ghng17 171 4 be be VB cord-269652-t7ghng17 171 5 indicated indicate VBN cord-269652-t7ghng17 171 6 for for IN cord-269652-t7ghng17 171 7 the the DT cord-269652-t7ghng17 171 8 source source NN cord-269652-t7ghng17 171 9 control control NN cord-269652-t7ghng17 171 10 of of IN cord-269652-t7ghng17 171 11 neonatal neonatal JJ cord-269652-t7ghng17 171 12 infections infection NNS cord-269652-t7ghng17 171 13 . . . cord-269652-t7ghng17 172 1 In in IN cord-269652-t7ghng17 172 2 a a DT cord-269652-t7ghng17 172 3 single single JJ cord-269652-t7ghng17 172 4 - - HYPH cord-269652-t7ghng17 172 5 center center NN cord-269652-t7ghng17 172 6 20-year 20-year JJ cord-269652-t7ghng17 172 7 retrospective retrospective JJ cord-269652-t7ghng17 172 8 study study NN cord-269652-t7ghng17 172 9 , , , cord-269652-t7ghng17 172 10 NEC NEC NNP cord-269652-t7ghng17 172 11 - - HYPH cord-269652-t7ghng17 172 12 associated associate VBN cord-269652-t7ghng17 172 13 blood blood NN cord-269652-t7ghng17 172 14 stream stream NN cord-269652-t7ghng17 172 15 infection infection NN cord-269652-t7ghng17 172 16 ( ( -LRB- cord-269652-t7ghng17 172 17 BSI BSI NNP cord-269652-t7ghng17 172 18 ) ) -RRB- cord-269652-t7ghng17 172 19 occurred occur VBD cord-269652-t7ghng17 172 20 within within IN cord-269652-t7ghng17 172 21 3 3 CD cord-269652-t7ghng17 172 22 days day NNS cord-269652-t7ghng17 172 23 of of IN cord-269652-t7ghng17 172 24 NEC NEC NNP cord-269652-t7ghng17 172 25 diagnosis diagnosis NN cord-269652-t7ghng17 172 26 and and CC cord-269652-t7ghng17 172 27 was be VBD cord-269652-t7ghng17 172 28 noted note VBN cord-269652-t7ghng17 172 29 in in IN cord-269652-t7ghng17 172 30 approximately approximately RB cord-269652-t7ghng17 172 31 43 43 CD cord-269652-t7ghng17 172 32 % % NN cord-269652-t7ghng17 172 33 ( ( -LRB- cord-269652-t7ghng17 172 34 69 69 CD cord-269652-t7ghng17 172 35 out out IN cord-269652-t7ghng17 172 36 of of IN cord-269652-t7ghng17 172 37 158 158 CD cord-269652-t7ghng17 172 38 infants infant NNS cord-269652-t7ghng17 172 39 with with IN cord-269652-t7ghng17 172 40 one one CD cord-269652-t7ghng17 172 41 episode episode NN cord-269652-t7ghng17 172 42 of of IN cord-269652-t7ghng17 172 43 BSI BSI NNP cord-269652-t7ghng17 172 44 ) ) -RRB- cord-269652-t7ghng17 172 45 . . . cord-269652-t7ghng17 173 1 Infants infant NNS cord-269652-t7ghng17 173 2 with with IN cord-269652-t7ghng17 173 3 NEC NEC NNP cord-269652-t7ghng17 173 4 - - HYPH cord-269652-t7ghng17 173 5 associated associate VBN cord-269652-t7ghng17 173 6 BSI BSI NNP cord-269652-t7ghng17 173 7 had have VBD cord-269652-t7ghng17 173 8 higher high JJR cord-269652-t7ghng17 173 9 odds odd NNS cord-269652-t7ghng17 173 10 ( ( -LRB- cord-269652-t7ghng17 173 11 adjusted adjust VBN cord-269652-t7ghng17 173 12 odds odd NNS cord-269652-t7ghng17 173 13 ratio ratio NN cord-269652-t7ghng17 173 14 3.51 3.51 CD cord-269652-t7ghng17 173 15 ; ; : cord-269652-t7ghng17 173 16 95 95 CD cord-269652-t7ghng17 173 17 % % NN cord-269652-t7ghng17 173 18 CI CI NNP cord-269652-t7ghng17 173 19 1.98 1.98 CD cord-269652-t7ghng17 173 20 - - SYM cord-269652-t7ghng17 173 21 6.24 6.24 CD cord-269652-t7ghng17 173 22 ) ) -RRB- cord-269652-t7ghng17 173 23 of of IN cord-269652-t7ghng17 173 24 having have VBG cord-269652-t7ghng17 173 25 surgical surgical JJ cord-269652-t7ghng17 173 26 interventions intervention NNS cord-269652-t7ghng17 173 27 compared compare VBN cord-269652-t7ghng17 173 28 with with IN cord-269652-t7ghng17 173 29 those those DT cord-269652-t7ghng17 173 30 without without IN cord-269652-t7ghng17 173 31 BSI BSI NNP cord-269652-t7ghng17 173 32 . . . cord-269652-t7ghng17 174 1 44 44 CD cord-269652-t7ghng17 175 1 It -PRON- PRP cord-269652-t7ghng17 175 2 is be VBZ cord-269652-t7ghng17 175 3 of of IN cord-269652-t7ghng17 175 4 utmost utmost JJ cord-269652-t7ghng17 175 5 importance importance NN cord-269652-t7ghng17 175 6 to to TO cord-269652-t7ghng17 175 7 correspond correspond VB cord-269652-t7ghng17 175 8 with with IN cord-269652-t7ghng17 175 9 pediatric pediatric JJ cord-269652-t7ghng17 175 10 surgery surgery NN cord-269652-t7ghng17 175 11 regarding regard VBG cord-269652-t7ghng17 175 12 source source NN cord-269652-t7ghng17 175 13 control control NN cord-269652-t7ghng17 175 14 of of IN cord-269652-t7ghng17 175 15 infection infection NN cord-269652-t7ghng17 175 16 if if IN cord-269652-t7ghng17 175 17 clinically clinically RB cord-269652-t7ghng17 175 18 indicated indicate VBN cord-269652-t7ghng17 175 19 because because IN cord-269652-t7ghng17 175 20 NEC NEC NNP cord-269652-t7ghng17 175 21 - - HYPH cord-269652-t7ghng17 175 22 associated associate VBN cord-269652-t7ghng17 175 23 BSI BSI NNP cord-269652-t7ghng17 175 24 had have VBD cord-269652-t7ghng17 175 25 higher high JJR cord-269652-t7ghng17 175 26 odds odd NNS cord-269652-t7ghng17 175 27 of of IN cord-269652-t7ghng17 175 28 death death NN cord-269652-t7ghng17 175 29 ( ( -LRB- cord-269652-t7ghng17 175 30 adjusted adjust VBN cord-269652-t7ghng17 175 31 odds odd NNS cord-269652-t7ghng17 175 32 ratio ratio NN cord-269652-t7ghng17 175 33 2.88 2.88 CD cord-269652-t7ghng17 175 34 ; ; : cord-269652-t7ghng17 175 35 95 95 CD cord-269652-t7ghng17 175 36 % % NN cord-269652-t7ghng17 175 37 CI CI NNP cord-269652-t7ghng17 175 38 1 1 CD cord-269652-t7ghng17 175 39 . . . cord-269652-t7ghng17 176 1 39 39 CD cord-269652-t7ghng17 176 2 - - SYM cord-269652-t7ghng17 176 3 5.97 5.97 CD cord-269652-t7ghng17 176 4 ) ) -RRB- cord-269652-t7ghng17 176 5 . . . cord-269652-t7ghng17 177 1 44 44 CD cord-269652-t7ghng17 178 1 The the DT cord-269652-t7ghng17 178 2 following follow VBG cord-269652-t7ghng17 178 3 includes include VBZ cord-269652-t7ghng17 178 4 disease disease NN cord-269652-t7ghng17 178 5 - - HYPH cord-269652-t7ghng17 178 6 specific specific JJ cord-269652-t7ghng17 178 7 conditions condition NNS cord-269652-t7ghng17 178 8 that that WDT cord-269652-t7ghng17 178 9 may may MD cord-269652-t7ghng17 178 10 require require VB cord-269652-t7ghng17 178 11 surgical surgical JJ cord-269652-t7ghng17 178 12 interventions intervention NNS cord-269652-t7ghng17 178 13 for for IN cord-269652-t7ghng17 178 14 adequate adequate JJ cord-269652-t7ghng17 178 15 source source NN cord-269652-t7ghng17 178 16 control control NN cord-269652-t7ghng17 178 17 of of IN cord-269652-t7ghng17 178 18 infections infection NNS cord-269652-t7ghng17 178 19 if if IN cord-269652-t7ghng17 178 20 the the DT cord-269652-t7ghng17 178 21 infant infant NN cord-269652-t7ghng17 178 22 is be VBZ cord-269652-t7ghng17 178 23 clinically clinically RB cord-269652-t7ghng17 178 24 stable stable JJ cord-269652-t7ghng17 178 25 . . . cord-269652-t7ghng17 179 1 Pediatric pediatric JJ cord-269652-t7ghng17 179 2 providers provider NNS cord-269652-t7ghng17 179 3 are be VBP cord-269652-t7ghng17 179 4 encouraged encourage VBN cord-269652-t7ghng17 179 5 to to TO cord-269652-t7ghng17 179 6 discuss discuss VB cord-269652-t7ghng17 179 7 with with IN cord-269652-t7ghng17 179 8 their -PRON- PRP$ cord-269652-t7ghng17 179 9 surgical surgical JJ cord-269652-t7ghng17 179 10 colleagues colleague NNS cord-269652-t7ghng17 179 11 the the DT cord-269652-t7ghng17 179 12 following follow VBG cord-269652-t7ghng17 179 13 surgical surgical JJ cord-269652-t7ghng17 179 14 treatment treatment NN cord-269652-t7ghng17 179 15 options option NNS cord-269652-t7ghng17 179 16 32 32 CD cord-269652-t7ghng17 179 17 : : : cord-269652-t7ghng17 179 18 Early early JJ cord-269652-t7ghng17 179 19 debridement debridement NN cord-269652-t7ghng17 179 20 of of IN cord-269652-t7ghng17 179 21 cutaneous cutaneous JJ cord-269652-t7ghng17 179 22 lesions lesion NNS cord-269652-t7ghng17 179 23 with with IN cord-269652-t7ghng17 179 24 disseminated disseminate VBN cord-269652-t7ghng17 179 25 aspergillosis aspergillosis NNP cord-269652-t7ghng17 179 26 Surgical surgical JJ cord-269652-t7ghng17 179 27 drainage drainage NN cord-269652-t7ghng17 179 28 of of IN cord-269652-t7ghng17 179 29 peritonitis peritonitis NN cord-269652-t7ghng17 179 30 with with IN cord-269652-t7ghng17 179 31 bowel bowel NN cord-269652-t7ghng17 179 32 rupture rupture NN cord-269652-t7ghng17 179 33 Wound Wound NNP cord-269652-t7ghng17 179 34 cleaning cleaning NN cord-269652-t7ghng17 179 35 and and CC cord-269652-t7ghng17 179 36 debridement debridement NN cord-269652-t7ghng17 179 37 rapidly rapidly RB cord-269652-t7ghng17 179 38 spreading spread VBG cord-269652-t7ghng17 179 39 cellulitis cellulitis NN cord-269652-t7ghng17 179 40 ( ( -LRB- cord-269652-t7ghng17 179 41 S S NNP cord-269652-t7ghng17 179 42 aureus aureus NN cord-269652-t7ghng17 179 43 ) ) -RRB- cord-269652-t7ghng17 179 44 , , , cord-269652-t7ghng17 179 45 necrotizing necrotize VBG cord-269652-t7ghng17 179 46 fasciitis fasciitis NN cord-269652-t7ghng17 179 47 ( ( -LRB- cord-269652-t7ghng17 179 48 group group NN cord-269652-t7ghng17 179 49 A a NN cord-269652-t7ghng17 179 50 or or CC cord-269652-t7ghng17 179 51 B b NN cord-269652-t7ghng17 179 52 streptococci streptococcus NNS cord-269652-t7ghng17 179 53 ) ) -RRB- cord-269652-t7ghng17 179 54 , , , cord-269652-t7ghng17 179 55 tetanus tetanus NN cord-269652-t7ghng17 179 56 neonatorum neonatorum NNP cord-269652-t7ghng17 179 57 Surgical surgical JJ cord-269652-t7ghng17 179 58 drainage drainage NN cord-269652-t7ghng17 179 59 of of IN cord-269652-t7ghng17 179 60 pus pus NN cord-269652-t7ghng17 179 61 in in IN cord-269652-t7ghng17 179 62 osteomyelitis osteomyelitis NN cord-269652-t7ghng17 179 63 and and CC cord-269652-t7ghng17 179 64 suppurative suppurative JJ cord-269652-t7ghng17 179 65 arthritis arthritis NN cord-269652-t7ghng17 179 66 Thoracostomy Thoracostomy NNP cord-269652-t7ghng17 179 67 drainage drainage NN cord-269652-t7ghng17 179 68 of of IN cord-269652-t7ghng17 179 69 empyema empyema JJ cord-269652-t7ghng17 179 70 Surgical surgical JJ cord-269652-t7ghng17 179 71 drainage drainage NN cord-269652-t7ghng17 179 72 of of IN cord-269652-t7ghng17 179 73 breast breast NN cord-269652-t7ghng17 179 74 abscess abscess NN cord-269652-t7ghng17 179 75 may may MD cord-269652-t7ghng17 179 76 be be VB cord-269652-t7ghng17 179 77 needed need VBN cord-269652-t7ghng17 179 78 to to TO cord-269652-t7ghng17 179 79 minimize minimize VB cord-269652-t7ghng17 179 80 damage damage NN cord-269652-t7ghng17 179 81 to to IN cord-269652-t7ghng17 179 82 breast breast NN cord-269652-t7ghng17 179 83 tissue tissue NN cord-269652-t7ghng17 179 84 . . . cord-269652-t7ghng17 180 1 Surgical surgical JJ cord-269652-t7ghng17 180 2 interventions intervention NNS cord-269652-t7ghng17 180 3 for for IN cord-269652-t7ghng17 180 4 primary primary JJ cord-269652-t7ghng17 180 5 diseases disease NNS cord-269652-t7ghng17 180 6 in in IN cord-269652-t7ghng17 180 7 infants infant NNS cord-269652-t7ghng17 180 8 may may MD cord-269652-t7ghng17 180 9 also also RB cord-269652-t7ghng17 180 10 increase increase VB cord-269652-t7ghng17 180 11 the the DT cord-269652-t7ghng17 180 12 risk risk NN cord-269652-t7ghng17 180 13 for for IN cord-269652-t7ghng17 180 14 neonatal neonatal JJ cord-269652-t7ghng17 180 15 infections infection NNS cord-269652-t7ghng17 180 16 . . . cord-269652-t7ghng17 181 1 Higher high JJR cord-269652-t7ghng17 181 2 rates rate NNS cord-269652-t7ghng17 181 3 of of IN cord-269652-t7ghng17 181 4 surgical surgical JJ cord-269652-t7ghng17 181 5 site site NN cord-269652-t7ghng17 181 6 infection infection NN cord-269652-t7ghng17 181 7 defined define VBN cord-269652-t7ghng17 181 8 as as IN cord-269652-t7ghng17 181 9 superficial superficial JJ cord-269652-t7ghng17 181 10 , , , cord-269652-t7ghng17 181 11 deep deep JJ cord-269652-t7ghng17 181 12 , , , cord-269652-t7ghng17 181 13 and and CC cord-269652-t7ghng17 181 14 organ organ NN cord-269652-t7ghng17 181 15 infections infection NNS cord-269652-t7ghng17 181 16 within within IN cord-269652-t7ghng17 181 17 30 30 CD cord-269652-t7ghng17 181 18 days day NNS cord-269652-t7ghng17 181 19 of of IN cord-269652-t7ghng17 181 20 surgical surgical JJ cord-269652-t7ghng17 181 21 procedures procedure NNS cord-269652-t7ghng17 181 22 were be VBD cord-269652-t7ghng17 181 23 noted note VBN cord-269652-t7ghng17 181 24 among among IN cord-269652-t7ghng17 181 25 infants infant NNS cord-269652-t7ghng17 181 26 following follow VBG cord-269652-t7ghng17 181 27 closure closure NN cord-269652-t7ghng17 181 28 of of IN cord-269652-t7ghng17 181 29 gastroschisis gastroschisis NN cord-269652-t7ghng17 181 30 . . . cord-269652-t7ghng17 182 1 45 45 CD cord-269652-t7ghng17 183 1 It -PRON- PRP cord-269652-t7ghng17 183 2 is be VBZ cord-269652-t7ghng17 183 3 important important JJ cord-269652-t7ghng17 183 4 to to TO cord-269652-t7ghng17 183 5 closely closely RB cord-269652-t7ghng17 183 6 monitor monitor VB cord-269652-t7ghng17 183 7 infants infant NNS cord-269652-t7ghng17 183 8 with with IN cord-269652-t7ghng17 183 9 surgical surgical JJ cord-269652-t7ghng17 183 10 site site NN cord-269652-t7ghng17 183 11 infection infection NN cord-269652-t7ghng17 183 12 because because IN cord-269652-t7ghng17 183 13 they -PRON- PRP cord-269652-t7ghng17 183 14 require require VBP cord-269652-t7ghng17 183 15 significantly significantly RB cord-269652-t7ghng17 183 16 longer long JJR cord-269652-t7ghng17 183 17 hospital hospital NN cord-269652-t7ghng17 183 18 stay stay NN cord-269652-t7ghng17 183 19 . . . cord-269652-t7ghng17 184 1 45 45 CD cord-269652-t7ghng17 184 2 _SP cord-269652-t7ghng17 185 1 There there EX cord-269652-t7ghng17 185 2 are be VBP cord-269652-t7ghng17 185 3 various various JJ cord-269652-t7ghng17 185 4 measures measure NNS cord-269652-t7ghng17 185 5 that that WDT cord-269652-t7ghng17 185 6 can can MD cord-269652-t7ghng17 185 7 be be VB cord-269652-t7ghng17 185 8 used use VBN cord-269652-t7ghng17 185 9 , , , cord-269652-t7ghng17 185 10 depending depend VBG cord-269652-t7ghng17 185 11 on on IN cord-269652-t7ghng17 185 12 the the DT cord-269652-t7ghng17 185 13 availability availability NN cord-269652-t7ghng17 185 14 of of IN cord-269652-t7ghng17 185 15 local local JJ cord-269652-t7ghng17 185 16 resources resource NNS cord-269652-t7ghng17 185 17 , , , cord-269652-t7ghng17 185 18 to to TO cord-269652-t7ghng17 185 19 prevent prevent VB cord-269652-t7ghng17 185 20 neonatal neonatal JJ cord-269652-t7ghng17 185 21 infections infection NNS cord-269652-t7ghng17 185 22 . . . cord-269652-t7ghng17 186 1 These these DT cord-269652-t7ghng17 186 2 include include VBP cord-269652-t7ghng17 186 3 but but CC cord-269652-t7ghng17 186 4 are be VBP cord-269652-t7ghng17 186 5 not not RB cord-269652-t7ghng17 186 6 limited limited JJ cord-269652-t7ghng17 186 7 to to IN cord-269652-t7ghng17 186 8 GBS GBS NNP cord-269652-t7ghng17 186 9 prophylaxis prophylaxis NN cord-269652-t7ghng17 186 10 , , , cord-269652-t7ghng17 186 11 hand hand NN cord-269652-t7ghng17 186 12 hygiene hygiene NN cord-269652-t7ghng17 186 13 , , , cord-269652-t7ghng17 186 14 immunization immunization NN cord-269652-t7ghng17 186 15 and and CC cord-269652-t7ghng17 186 16 immunoprophylaxis immunoprophylaxis NNP cord-269652-t7ghng17 186 17 , , , cord-269652-t7ghng17 186 18 ASP ASP NNP cord-269652-t7ghng17 186 19 , , , cord-269652-t7ghng17 186 20 probiotics probiotic NNS cord-269652-t7ghng17 186 21 and and CC cord-269652-t7ghng17 186 22 prebiotics prebiotic NNS cord-269652-t7ghng17 186 23 , , , cord-269652-t7ghng17 186 24 and and CC cord-269652-t7ghng17 186 25 care care VB cord-269652-t7ghng17 186 26 bundles bundle NNS cord-269652-t7ghng17 186 27 . . . cord-269652-t7ghng17 187 1 IAP IAP NNP cord-269652-t7ghng17 187 2 is be VBZ cord-269652-t7ghng17 187 3 the the DT cord-269652-t7ghng17 187 4 only only JJ cord-269652-t7ghng17 187 5 preventive preventive JJ cord-269652-t7ghng17 187 6 strategy strategy NN cord-269652-t7ghng17 187 7 that that WDT cord-269652-t7ghng17 187 8 substantially substantially RB cord-269652-t7ghng17 187 9 reduces reduce VBZ cord-269652-t7ghng17 187 10 the the DT cord-269652-t7ghng17 187 11 incidence incidence NN cord-269652-t7ghng17 187 12 of of IN cord-269652-t7ghng17 187 13 earlyonset earlyonset NNP cord-269652-t7ghng17 187 14 GBS GBS NNP cord-269652-t7ghng17 187 15 . . . cord-269652-t7ghng17 188 1 7 7 CD cord-269652-t7ghng17 188 2 , , , cord-269652-t7ghng17 188 3 46 46 CD cord-269652-t7ghng17 189 1 The the DT cord-269652-t7ghng17 189 2 following follow VBG cord-269652-t7ghng17 189 3 are be VBP cord-269652-t7ghng17 189 4 indications indication NNS cord-269652-t7ghng17 189 5 for for IN cord-269652-t7ghng17 189 6 IAP IAP NNP cord-269652-t7ghng17 189 7 : : : cord-269652-t7ghng17 189 8 Previous previous JJ cord-269652-t7ghng17 189 9 infant infant NN cord-269652-t7ghng17 189 10 with with IN cord-269652-t7ghng17 189 11 invasive invasive JJ cord-269652-t7ghng17 189 12 GBS GBS NNP cord-269652-t7ghng17 189 13 disease disease NN cord-269652-t7ghng17 189 14 GBS GBS NNP cord-269652-t7ghng17 189 15 bacteriuria bacteriuria NN cord-269652-t7ghng17 189 16 during during IN cord-269652-t7ghng17 189 17 the the DT cord-269652-t7ghng17 189 18 current current JJ cord-269652-t7ghng17 189 19 pregnancy pregnancy NN cord-269652-t7ghng17 189 20 Positive positive JJ cord-269652-t7ghng17 189 21 GBS GBS NNP cord-269652-t7ghng17 189 22 vaginal vaginal JJ cord-269652-t7ghng17 189 23 - - HYPH cord-269652-t7ghng17 189 24 rectal rectal JJ cord-269652-t7ghng17 189 25 screening screening NN cord-269652-t7ghng17 189 26 ( ( -LRB- cord-269652-t7ghng17 189 27 at at IN cord-269652-t7ghng17 189 28 35 35 CD cord-269652-t7ghng17 189 29 - - SYM cord-269652-t7ghng17 189 30 37 37 CD cord-269652-t7ghng17 189 31 week week NN cord-269652-t7ghng17 189 32 gestation gestation NN cord-269652-t7ghng17 189 33 ) ) -RRB- cord-269652-t7ghng17 189 34 except except IN cord-269652-t7ghng17 189 35 for for IN cord-269652-t7ghng17 189 36 cesarean cesarean NN cord-269652-t7ghng17 189 37 delivery delivery NN cord-269652-t7ghng17 189 38 without without IN cord-269652-t7ghng17 189 39 labor labor NN cord-269652-t7ghng17 189 40 or or CC cord-269652-t7ghng17 189 41 ruptured ruptured JJ cord-269652-t7ghng17 189 42 membrane membrane NN cord-269652-t7ghng17 189 43 Unknown unknown JJ cord-269652-t7ghng17 189 44 maternal maternal JJ cord-269652-t7ghng17 189 45 GBS GBS NNP cord-269652-t7ghng17 189 46 status status NN cord-269652-t7ghng17 189 47 with with IN cord-269652-t7ghng17 189 48 delivery delivery NN cord-269652-t7ghng17 189 49 at at IN cord-269652-t7ghng17 189 50 less less JJR cord-269652-t7ghng17 189 51 than than IN cord-269652-t7ghng17 189 52 37 37 CD cord-269652-t7ghng17 189 53 weeks week NNS cord-269652-t7ghng17 189 54 , , , cord-269652-t7ghng17 189 55 rupture rupture NN cord-269652-t7ghng17 189 56 of of IN cord-269652-t7ghng17 189 57 membrane membrane NN cord-269652-t7ghng17 189 58 at at IN cord-269652-t7ghng17 189 59 or or CC cord-269652-t7ghng17 189 60 before before IN cord-269652-t7ghng17 189 61 18 18 CD cord-269652-t7ghng17 189 62 hours hour NNS cord-269652-t7ghng17 189 63 , , , cord-269652-t7ghng17 189 64 or or CC cord-269652-t7ghng17 189 65 fever fever NN cord-269652-t7ghng17 189 66 equal equal JJ cord-269652-t7ghng17 189 67 to to IN cord-269652-t7ghng17 189 68 or or CC cord-269652-t7ghng17 189 69 greater great JJR cord-269652-t7ghng17 189 70 than than IN cord-269652-t7ghng17 189 71 100.4 100.4 CD cord-269652-t7ghng17 189 72 F f NN cord-269652-t7ghng17 189 73 ( ( -LRB- cord-269652-t7ghng17 189 74 ! ! . cord-269652-t7ghng17 189 75 38 38 CD cord-269652-t7ghng17 189 76 C c NN cord-269652-t7ghng17 189 77 ) ) -RRB- cord-269652-t7ghng17 189 78 . . . cord-269652-t7ghng17 190 1 Adequate adequate JJ cord-269652-t7ghng17 190 2 IAP IAP NNP cord-269652-t7ghng17 190 3 means mean VBZ cord-269652-t7ghng17 190 4 receiving receive VBG cord-269652-t7ghng17 190 5 penicillin penicillin NN cord-269652-t7ghng17 190 6 , , , cord-269652-t7ghng17 190 7 ampicillin ampicillin NN cord-269652-t7ghng17 190 8 , , , cord-269652-t7ghng17 190 9 or or CC cord-269652-t7ghng17 190 10 cefazolin cefazolin VBN cord-269652-t7ghng17 190 11 for for IN cord-269652-t7ghng17 190 12 at at RB cord-269652-t7ghng17 190 13 least least JJS cord-269652-t7ghng17 190 14 4 4 CD cord-269652-t7ghng17 190 15 hours hour NNS cord-269652-t7ghng17 190 16 before before IN cord-269652-t7ghng17 190 17 delivery delivery NN cord-269652-t7ghng17 190 18 . . . cord-269652-t7ghng17 191 1 Cefazolin Cefazolin NNP cord-269652-t7ghng17 191 2 may may MD cord-269652-t7ghng17 191 3 be be VB cord-269652-t7ghng17 191 4 used use VBN cord-269652-t7ghng17 191 5 if if IN cord-269652-t7ghng17 191 6 with with IN cord-269652-t7ghng17 191 7 nonserious nonserious JJ cord-269652-t7ghng17 191 8 b b NN cord-269652-t7ghng17 191 9 - - HYPH cord-269652-t7ghng17 191 10 lactam lactam NN cord-269652-t7ghng17 191 11 allergy allergy NN cord-269652-t7ghng17 191 12 . . . cord-269652-t7ghng17 192 1 If if IN cord-269652-t7ghng17 192 2 there there EX cord-269652-t7ghng17 192 3 is be VBZ cord-269652-t7ghng17 192 4 history history NN cord-269652-t7ghng17 192 5 of of IN cord-269652-t7ghng17 192 6 serious serious JJ cord-269652-t7ghng17 192 7 b b NN cord-269652-t7ghng17 192 8 - - HYPH cord-269652-t7ghng17 192 9 lactam lactam NN cord-269652-t7ghng17 192 10 allergy allergy NN cord-269652-t7ghng17 192 11 ( ( -LRB- cord-269652-t7ghng17 192 12 anaphylaxis anaphylaxis NN cord-269652-t7ghng17 192 13 , , , cord-269652-t7ghng17 192 14 angioedema angioedema NN cord-269652-t7ghng17 192 15 , , , cord-269652-t7ghng17 192 16 respiratory respiratory JJ cord-269652-t7ghng17 192 17 insufficiency insufficiency NN cord-269652-t7ghng17 192 18 , , , cord-269652-t7ghng17 192 19 or or CC cord-269652-t7ghng17 192 20 urticarial urticarial JJ cord-269652-t7ghng17 192 21 rash rash NN cord-269652-t7ghng17 192 22 ) ) -RRB- cord-269652-t7ghng17 192 23 and and CC cord-269652-t7ghng17 192 24 if if IN cord-269652-t7ghng17 192 25 GBS GBS NNP cord-269652-t7ghng17 192 26 isolate isolate VBP cord-269652-t7ghng17 192 27 is be VBZ cord-269652-t7ghng17 192 28 susceptible susceptible JJ cord-269652-t7ghng17 192 29 , , , cord-269652-t7ghng17 192 30 clindamycin clindamycin NN cord-269652-t7ghng17 192 31 may may MD cord-269652-t7ghng17 192 32 be be VB cord-269652-t7ghng17 192 33 used use VBN cord-269652-t7ghng17 192 34 . . . cord-269652-t7ghng17 193 1 Otherwise otherwise RB cord-269652-t7ghng17 193 2 , , , cord-269652-t7ghng17 193 3 vancomycin vancomycin NN cord-269652-t7ghng17 193 4 is be VBZ cord-269652-t7ghng17 193 5 an an DT cord-269652-t7ghng17 193 6 alternative alternative NN cord-269652-t7ghng17 193 7 . . . cord-269652-t7ghng17 194 1 Because because IN cord-269652-t7ghng17 194 2 of of IN cord-269652-t7ghng17 194 3 high high JJ cord-269652-t7ghng17 194 4 resistance resistance NN cord-269652-t7ghng17 194 5 rates rate NNS cord-269652-t7ghng17 194 6 , , , cord-269652-t7ghng17 194 7 erythromycin erythromycin NN cord-269652-t7ghng17 194 8 is be VBZ cord-269652-t7ghng17 194 9 not not RB cord-269652-t7ghng17 194 10 recommended recommend VBN cord-269652-t7ghng17 194 11 . . . cord-269652-t7ghng17 195 1 The the DT cord-269652-t7ghng17 195 2 Center Center NNP cord-269652-t7ghng17 195 3 for for IN cord-269652-t7ghng17 195 4 Disease Disease NNP cord-269652-t7ghng17 195 5 Control Control NNP cord-269652-t7ghng17 195 6 and and CC cord-269652-t7ghng17 195 7 Prevention Prevention NNP cord-269652-t7ghng17 195 8 has have VBZ cord-269652-t7ghng17 195 9 an an DT cord-269652-t7ghng17 195 10 extensive extensive JJ cord-269652-t7ghng17 195 11 online online JJ cord-269652-t7ghng17 195 12 resource resource NN cord-269652-t7ghng17 195 13 on on IN cord-269652-t7ghng17 195 14 GBS GBS NNP cord-269652-t7ghng17 195 15 for for IN cord-269652-t7ghng17 195 16 clinicians clinician NNS cord-269652-t7ghng17 195 17 , , , cord-269652-t7ghng17 195 18 including include VBG cord-269652-t7ghng17 195 19 the the DT cord-269652-t7ghng17 195 20 algorithm algorithm NN cord-269652-t7ghng17 195 21 - - HYPH cord-269652-t7ghng17 195 22 based base VBN cord-269652-t7ghng17 195 23 guidance guidance NN cord-269652-t7ghng17 195 24 on on IN cord-269652-t7ghng17 195 25 secondary secondary JJ cord-269652-t7ghng17 195 26 prevention prevention NN cord-269652-t7ghng17 195 27 of of IN cord-269652-t7ghng17 195 28 EOS EOS NNP cord-269652-t7ghng17 195 29 in in IN cord-269652-t7ghng17 195 30 newborns newborn NNS cord-269652-t7ghng17 195 31 . . . cord-269652-t7ghng17 196 1 47 47 CD cord-269652-t7ghng17 197 1 The the DT cord-269652-t7ghng17 197 2 Web web NN cord-269652-t7ghng17 197 3 page page NN cord-269652-t7ghng17 197 4 also also RB cord-269652-t7ghng17 197 5 provides provide VBZ cord-269652-t7ghng17 197 6 an an DT cord-269652-t7ghng17 197 7 application application NN cord-269652-t7ghng17 197 8 , , , cord-269652-t7ghng17 197 9 Prevent Prevent NNP cord-269652-t7ghng17 197 10 Group Group NNP cord-269652-t7ghng17 197 11 B B NNP cord-269652-t7ghng17 197 12 Strep Strep NNP cord-269652-t7ghng17 197 13 , , , cord-269652-t7ghng17 197 14 which which WDT cord-269652-t7ghng17 197 15 includes include VBZ cord-269652-t7ghng17 197 16 guidance guidance NN cord-269652-t7ghng17 197 17 on on IN cord-269652-t7ghng17 197 18 various various JJ cord-269652-t7ghng17 197 19 patient patient JJ cord-269652-t7ghng17 197 20 scenarios scenario NNS cord-269652-t7ghng17 197 21 in in IN cord-269652-t7ghng17 197 22 collaboration collaboration NN cord-269652-t7ghng17 197 23 with with IN cord-269652-t7ghng17 197 24 different different JJ cord-269652-t7ghng17 197 25 medical medical JJ cord-269652-t7ghng17 197 26 societies society NNS cord-269652-t7ghng17 197 27 , , , cord-269652-t7ghng17 197 28 such such JJ cord-269652-t7ghng17 197 29 as as IN cord-269652-t7ghng17 197 30 the the DT cord-269652-t7ghng17 197 31 AAP AAP NNP cord-269652-t7ghng17 197 32 and and CC cord-269652-t7ghng17 197 33 the the DT cord-269652-t7ghng17 197 34 American American NNP cord-269652-t7ghng17 197 35 College College NNP cord-269652-t7ghng17 197 36 of of IN cord-269652-t7ghng17 197 37 Obstetricians Obstetricians NNPS cord-269652-t7ghng17 197 38 and and CC cord-269652-t7ghng17 197 39 Gynecologists Gynecologists NNPS cord-269652-t7ghng17 198 1 ( ( -LRB- cord-269652-t7ghng17 198 2 http://www.cdc.gov/groupBstrep/guidelines/index.html http://www.cdc.gov/groupBstrep/guidelines/index.html NNP cord-269652-t7ghng17 198 3 ) ) -RRB- cord-269652-t7ghng17 198 4 . . . cord-269652-t7ghng17 199 1 There there EX cord-269652-t7ghng17 199 2 is be VBZ cord-269652-t7ghng17 199 3 no no DT cord-269652-t7ghng17 199 4 doubt doubt NN cord-269652-t7ghng17 199 5 that that IN cord-269652-t7ghng17 199 6 hand hand NN cord-269652-t7ghng17 199 7 hygiene hygiene NN cord-269652-t7ghng17 199 8 remains remain VBZ cord-269652-t7ghng17 199 9 the the DT cord-269652-t7ghng17 199 10 cornerstone cornerstone NN cord-269652-t7ghng17 199 11 in in IN cord-269652-t7ghng17 199 12 decreasing decrease VBG cord-269652-t7ghng17 199 13 health health NN cord-269652-t7ghng17 199 14 care care NN cord-269652-t7ghng17 199 15 - - HYPH cord-269652-t7ghng17 199 16 associated associate VBN cord-269652-t7ghng17 199 17 infections infection NNS cord-269652-t7ghng17 199 18 in in IN cord-269652-t7ghng17 199 19 different different JJ cord-269652-t7ghng17 199 20 hospital hospital NN cord-269652-t7ghng17 199 21 settings setting NNS cord-269652-t7ghng17 199 22 , , , cord-269652-t7ghng17 199 23 including include VBG cord-269652-t7ghng17 199 24 the the DT cord-269652-t7ghng17 199 25 NICU NICU NNP cord-269652-t7ghng17 199 26 . . . cord-269652-t7ghng17 200 1 In in IN cord-269652-t7ghng17 200 2 fact fact NN cord-269652-t7ghng17 200 3 , , , cord-269652-t7ghng17 200 4 there there EX cord-269652-t7ghng17 200 5 are be VBP cord-269652-t7ghng17 200 6 various various JJ cord-269652-t7ghng17 200 7 educational educational JJ cord-269652-t7ghng17 200 8 programs program NNS cord-269652-t7ghng17 200 9 , , , cord-269652-t7ghng17 200 10 multidisciplinary multidisciplinary JJ cord-269652-t7ghng17 200 11 quality quality NN cord-269652-t7ghng17 200 12 - - HYPH cord-269652-t7ghng17 200 13 improvement improvement NN cord-269652-t7ghng17 200 14 teams team NNS cord-269652-t7ghng17 200 15 , , , cord-269652-t7ghng17 200 16 and and CC cord-269652-t7ghng17 200 17 guidelines guideline NNS cord-269652-t7ghng17 200 18 on on IN cord-269652-t7ghng17 200 19 the the DT cord-269652-t7ghng17 200 20 proven prove VBN cord-269652-t7ghng17 200 21 effectiveness effectiveness NN cord-269652-t7ghng17 200 22 of of IN cord-269652-t7ghng17 200 23 hand hand NN cord-269652-t7ghng17 200 24 hygiene hygiene NN cord-269652-t7ghng17 200 25 in in IN cord-269652-t7ghng17 200 26 decreasing decrease VBG cord-269652-t7ghng17 200 27 infection infection NN cord-269652-t7ghng17 200 28 ; ; : cord-269652-t7ghng17 200 29 however however RB cord-269652-t7ghng17 200 30 , , , cord-269652-t7ghng17 200 31 this this DT cord-269652-t7ghng17 200 32 is be VBZ cord-269652-t7ghng17 200 33 significantly significantly RB cord-269652-t7ghng17 200 34 affected affect VBN cord-269652-t7ghng17 200 35 by by IN cord-269652-t7ghng17 200 36 compliance compliance NN cord-269652-t7ghng17 200 37 . . . cord-269652-t7ghng17 201 1 48 48 CD cord-269652-t7ghng17 201 2 , , , cord-269652-t7ghng17 201 3 49 49 CD cord-269652-t7ghng17 201 4 The the DT cord-269652-t7ghng17 201 5 Center Center NNP cord-269652-t7ghng17 201 6 for for IN cord-269652-t7ghng17 201 7 Disease Disease NNP cord-269652-t7ghng17 201 8 Control Control NNP cord-269652-t7ghng17 201 9 and and CC cord-269652-t7ghng17 201 10 Prevention Prevention NNP cord-269652-t7ghng17 201 11 has have VBZ cord-269652-t7ghng17 201 12 a a DT cord-269652-t7ghng17 201 13 Web web NN cord-269652-t7ghng17 201 14 site site NN cord-269652-t7ghng17 201 15 ( ( -LRB- cord-269652-t7ghng17 201 16 http://www.cdc.gov/handhygiene/ http://www.cdc.gov/handhygiene/ ADD cord-269652-t7ghng17 201 17 ) ) -RRB- cord-269652-t7ghng17 201 18 containing contain VBG cord-269652-t7ghng17 201 19 resources resource NNS cord-269652-t7ghng17 201 20 for for IN cord-269652-t7ghng17 201 21 hand hand NN cord-269652-t7ghng17 201 22 hygiene hygiene NN cord-269652-t7ghng17 201 23 in in IN cord-269652-t7ghng17 201 24 health health NN cord-269652-t7ghng17 201 25 care care NN cord-269652-t7ghng17 201 26 settings setting NNS cord-269652-t7ghng17 201 27 including include VBG cord-269652-t7ghng17 201 28 an an DT cord-269652-t7ghng17 201 29 application application NN cord-269652-t7ghng17 201 30 , , , cord-269652-t7ghng17 201 31 iScrub iScrub NNP cord-269652-t7ghng17 201 32 , , , cord-269652-t7ghng17 201 33 for for IN cord-269652-t7ghng17 201 34 monitoring monitor VBG cord-269652-t7ghng17 201 35 hand hand NN cord-269652-t7ghng17 201 36 hygiene hygiene NN cord-269652-t7ghng17 201 37 compliance compliance NN cord-269652-t7ghng17 201 38 using use VBG cord-269652-t7ghng17 201 39 an an DT cord-269652-t7ghng17 201 40 iPhone iPhone NNP cord-269652-t7ghng17 201 41 or or CC cord-269652-t7ghng17 201 42 iPod iPod NNP cord-269652-t7ghng17 201 43 Touch Touch NNP cord-269652-t7ghng17 201 44 . . . cord-269652-t7ghng17 202 1 50 50 CD cord-269652-t7ghng17 203 1 Thus thus RB cord-269652-t7ghng17 203 2 , , , cord-269652-t7ghng17 203 3 hand hand NN cord-269652-t7ghng17 203 4 hygiene hygiene NN cord-269652-t7ghng17 203 5 guidelines guideline NNS cord-269652-t7ghng17 203 6 are be VBP cord-269652-t7ghng17 203 7 effective effective JJ cord-269652-t7ghng17 203 8 in in IN cord-269652-t7ghng17 203 9 reducing reduce VBG cord-269652-t7ghng17 203 10 infections infection NNS cord-269652-t7ghng17 203 11 only only RB cord-269652-t7ghng17 203 12 if if IN cord-269652-t7ghng17 203 13 we -PRON- PRP cord-269652-t7ghng17 203 14 use use VBP cord-269652-t7ghng17 203 15 it -PRON- PRP cord-269652-t7ghng17 203 16 . . . cord-269652-t7ghng17 204 1 Soap soap NN cord-269652-t7ghng17 204 2 and and CC cord-269652-t7ghng17 204 3 water water NN cord-269652-t7ghng17 204 4 is be VBZ cord-269652-t7ghng17 204 5 recommended recommend VBN cord-269652-t7ghng17 204 6 for for IN cord-269652-t7ghng17 204 7 decontaminating decontaminate VBG cord-269652-t7ghng17 204 8 visibly visibly RB cord-269652-t7ghng17 204 9 soiled soil VBN cord-269652-t7ghng17 204 10 hands hand NNS cord-269652-t7ghng17 204 11 by by IN cord-269652-t7ghng17 204 12 rubbing rub VBG cord-269652-t7ghng17 204 13 hands hand NNS cord-269652-t7ghng17 204 14 together together RB cord-269652-t7ghng17 204 15 vigorously vigorously RB cord-269652-t7ghng17 204 16 for for IN cord-269652-t7ghng17 204 17 15 15 CD cord-269652-t7ghng17 204 18 seconds second NNS cord-269652-t7ghng17 204 19 . . . cord-269652-t7ghng17 205 1 48 48 CD cord-269652-t7ghng17 205 2 , , , cord-269652-t7ghng17 205 3 49 49 CD cord-269652-t7ghng17 205 4 Alcohol alcohol NN cord-269652-t7ghng17 205 5 - - HYPH cord-269652-t7ghng17 205 6 based base VBN cord-269652-t7ghng17 205 7 gel gel NN cord-269652-t7ghng17 205 8 or or CC cord-269652-t7ghng17 205 9 foam foam NN cord-269652-t7ghng17 205 10 or or CC cord-269652-t7ghng17 205 11 an an DT cord-269652-t7ghng17 205 12 antiseptic antiseptic JJ cord-269652-t7ghng17 205 13 soap soap NN cord-269652-t7ghng17 205 14 may may MD cord-269652-t7ghng17 205 15 be be VB cord-269652-t7ghng17 205 16 used use VBN cord-269652-t7ghng17 205 17 for for IN cord-269652-t7ghng17 205 18 routine routine JJ cord-269652-t7ghng17 205 19 hand hand NN cord-269652-t7ghng17 205 20 hygiene hygiene NN cord-269652-t7ghng17 205 21 if if IN cord-269652-t7ghng17 205 22 not not RB cord-269652-t7ghng17 205 23 grossly grossly RB cord-269652-t7ghng17 205 24 contaminated contaminate VBN cord-269652-t7ghng17 205 25 . . . cord-269652-t7ghng17 206 1 48 48 CD cord-269652-t7ghng17 206 2 , , , cord-269652-t7ghng17 206 3 49 49 CD cord-269652-t7ghng17 206 4 Hand hand NN cord-269652-t7ghng17 206 5 hygiene hygiene NN cord-269652-t7ghng17 206 6 compliance compliance NN cord-269652-t7ghng17 206 7 is be VBZ cord-269652-t7ghng17 206 8 improved improve VBN cord-269652-t7ghng17 206 9 if if IN cord-269652-t7ghng17 206 10 with with IN cord-269652-t7ghng17 206 11 available available JJ cord-269652-t7ghng17 206 12 alcohol alcohol NN cord-269652-t7ghng17 206 13 - - HYPH cord-269652-t7ghng17 206 14 based base VBN cord-269652-t7ghng17 206 15 products product NNS cord-269652-t7ghng17 206 16 at at IN cord-269652-t7ghng17 206 17 the the DT cord-269652-t7ghng17 206 18 infant infant NN cord-269652-t7ghng17 206 19 's 's POS cord-269652-t7ghng17 206 20 bedside bedside NN cord-269652-t7ghng17 206 21 . . . cord-269652-t7ghng17 207 1 48 48 CD cord-269652-t7ghng17 207 2 Antimicrobial Antimicrobial NNP cord-269652-t7ghng17 207 3 - - HYPH cord-269652-t7ghng17 207 4 impregnated impregnate VBN cord-269652-t7ghng17 207 5 towelettes towelette NNS cord-269652-t7ghng17 207 6 or or CC cord-269652-t7ghng17 207 7 wipes wipe NNS cord-269652-t7ghng17 207 8 are be VBP cord-269652-t7ghng17 207 9 considered consider VBN cord-269652-t7ghng17 207 10 alternatives alternative NNS cord-269652-t7ghng17 207 11 but but CC cord-269652-t7ghng17 207 12 not not RB cord-269652-t7ghng17 207 13 substitutes substitute NNS cord-269652-t7ghng17 207 14 for for IN cord-269652-t7ghng17 207 15 washing washing NN cord-269652-t7ghng17 207 16 with with IN cord-269652-t7ghng17 207 17 soap soap NN cord-269652-t7ghng17 207 18 and and CC cord-269652-t7ghng17 207 19 water water NN cord-269652-t7ghng17 207 20 or or CC cord-269652-t7ghng17 207 21 alcohol alcohol NN cord-269652-t7ghng17 207 22 - - HYPH cord-269652-t7ghng17 207 23 based base VBN cord-269652-t7ghng17 207 24 gel gel NN cord-269652-t7ghng17 207 25 or or CC cord-269652-t7ghng17 207 26 foam foam NN cord-269652-t7ghng17 207 27 . . . cord-269652-t7ghng17 208 1 49 49 CD cord-269652-t7ghng17 208 2 _SP cord-269652-t7ghng17 209 1 The the DT cord-269652-t7ghng17 209 2 development development NN cord-269652-t7ghng17 209 3 of of IN cord-269652-t7ghng17 209 4 a a DT cord-269652-t7ghng17 209 5 safe safe JJ cord-269652-t7ghng17 209 6 and and CC cord-269652-t7ghng17 209 7 effective effective JJ cord-269652-t7ghng17 209 8 vaccine vaccine NN cord-269652-t7ghng17 209 9 is be VBZ cord-269652-t7ghng17 209 10 arguably arguably RB cord-269652-t7ghng17 209 11 one one CD cord-269652-t7ghng17 209 12 of of IN cord-269652-t7ghng17 209 13 the the DT cord-269652-t7ghng17 209 14 greatest great JJS cord-269652-t7ghng17 209 15 medical medical JJ cord-269652-t7ghng17 209 16 interventions intervention NNS cord-269652-t7ghng17 209 17 in in IN cord-269652-t7ghng17 209 18 the the DT cord-269652-t7ghng17 209 19 last last JJ cord-269652-t7ghng17 209 20 century century NN cord-269652-t7ghng17 209 21 . . . cord-269652-t7ghng17 210 1 51 51 CD cord-269652-t7ghng17 210 2 Hepatitis Hepatitis NNP cord-269652-t7ghng17 210 3 B B NNP cord-269652-t7ghng17 210 4 vaccine vaccine NN cord-269652-t7ghng17 210 5 is be VBZ cord-269652-t7ghng17 210 6 the the DT cord-269652-t7ghng17 210 7 only only JJ cord-269652-t7ghng17 210 8 agent agent NN cord-269652-t7ghng17 210 9 in in IN cord-269652-t7ghng17 210 10 the the DT cord-269652-t7ghng17 210 11 United United NNP cord-269652-t7ghng17 210 12 States States NNP cord-269652-t7ghng17 210 13 recommended recommend VBD cord-269652-t7ghng17 210 14 to to TO cord-269652-t7ghng17 210 15 be be VB cord-269652-t7ghng17 210 16 administered administer VBN cord-269652-t7ghng17 210 17 at at IN cord-269652-t7ghng17 210 18 birth birth NN cord-269652-t7ghng17 210 19 . . . cord-269652-t7ghng17 211 1 The the DT cord-269652-t7ghng17 211 2 various various JJ cord-269652-t7ghng17 211 3 brands brand NNS cord-269652-t7ghng17 211 4 available available JJ cord-269652-t7ghng17 211 5 in in IN cord-269652-t7ghng17 211 6 the the DT cord-269652-t7ghng17 211 7 United United NNP cord-269652-t7ghng17 211 8 States States NNP cord-269652-t7ghng17 211 9 have have VBP cord-269652-t7ghng17 211 10 an an DT cord-269652-t7ghng17 211 11 efficacy efficacy NN cord-269652-t7ghng17 211 12 of of IN cord-269652-t7ghng17 211 13 90 90 CD cord-269652-t7ghng17 211 14 % % NN cord-269652-t7ghng17 211 15 to to TO cord-269652-t7ghng17 211 16 95 95 CD cord-269652-t7ghng17 211 17 % % NN cord-269652-t7ghng17 211 18 in in IN cord-269652-t7ghng17 211 19 preventing prevent VBG cord-269652-t7ghng17 211 20 hepatitis hepatitis NN cord-269652-t7ghng17 211 21 B B NNP cord-269652-t7ghng17 211 22 virus virus NN cord-269652-t7ghng17 211 23 infection infection NN cord-269652-t7ghng17 211 24 and and CC cord-269652-t7ghng17 211 25 disease disease NN cord-269652-t7ghng17 211 26 . . . cord-269652-t7ghng17 212 1 52 52 CD cord-269652-t7ghng17 212 2 Additional additional JJ cord-269652-t7ghng17 212 3 information information NN cord-269652-t7ghng17 212 4 regarding regard VBG cord-269652-t7ghng17 212 5 recommended recommend VBN cord-269652-t7ghng17 212 6 dosages dosage NNS cord-269652-t7ghng17 212 7 of of IN cord-269652-t7ghng17 212 8 hepatitis hepatitis NN cord-269652-t7ghng17 212 9 B b NN cord-269652-t7ghng17 212 10 vaccines vaccine NNS cord-269652-t7ghng17 212 11 are be VBP cord-269652-t7ghng17 212 12 available available JJ cord-269652-t7ghng17 212 13 in in IN cord-269652-t7ghng17 212 14 the the DT cord-269652-t7ghng17 212 15 most most RBS cord-269652-t7ghng17 212 16 recent recent JJ cord-269652-t7ghng17 212 17 edition edition NN cord-269652-t7ghng17 212 18 of of IN cord-269652-t7ghng17 212 19 the the DT cord-269652-t7ghng17 212 20 Red Red NNP cord-269652-t7ghng17 212 21 Book Book NNP cord-269652-t7ghng17 212 22 52 52 CD cord-269652-t7ghng17 212 23 and and CC cord-269652-t7ghng17 212 24 in in IN cord-269652-t7ghng17 212 25 the the DT cord-269652-t7ghng17 212 26 annual annual JJ cord-269652-t7ghng17 212 27 publication publication NN cord-269652-t7ghng17 212 28 from from IN cord-269652-t7ghng17 212 29 the the DT cord-269652-t7ghng17 212 30 Advisory Advisory NNP cord-269652-t7ghng17 212 31 Committee Committee NNP cord-269652-t7ghng17 212 32 on on IN cord-269652-t7ghng17 212 33 Immunization Immunization NNP cord-269652-t7ghng17 212 34 Practices Practices NNPS cord-269652-t7ghng17 212 35 . . . cord-269652-t7ghng17 213 1 53 53 CD cord-269652-t7ghng17 214 1 The the DT cord-269652-t7ghng17 214 2 first first JJ cord-269652-t7ghng17 214 3 dose dose NN cord-269652-t7ghng17 214 4 in in IN cord-269652-t7ghng17 214 5 the the DT cord-269652-t7ghng17 214 6 primary primary JJ cord-269652-t7ghng17 214 7 series series NN cord-269652-t7ghng17 214 8 of of IN cord-269652-t7ghng17 214 9 the the DT cord-269652-t7ghng17 214 10 subsequent subsequent JJ cord-269652-t7ghng17 214 11 vaccines vaccine NNS cord-269652-t7ghng17 214 12 ( ( -LRB- cord-269652-t7ghng17 214 13 diphtheria diphtheria NN cord-269652-t7ghng17 214 14 and and CC cord-269652-t7ghng17 214 15 tetanus tetanus NN cord-269652-t7ghng17 214 16 toxoids toxoid NNS cord-269652-t7ghng17 214 17 and and CC cord-269652-t7ghng17 214 18 acellular acellular JJ cord-269652-t7ghng17 214 19 pertussis pertussis NN cord-269652-t7ghng17 214 20 vaccine vaccine NN cord-269652-t7ghng17 214 21 [ [ -LRB- cord-269652-t7ghng17 214 22 DTaP DTaP NNP cord-269652-t7ghng17 214 23 ] ] -RRB- cord-269652-t7ghng17 214 24 , , , cord-269652-t7ghng17 214 25 Haemophilus Haemophilus NNP cord-269652-t7ghng17 214 26 influenza influenza NN cord-269652-t7ghng17 214 27 type type NN cord-269652-t7ghng17 214 28 B b NN cord-269652-t7ghng17 214 29 , , , cord-269652-t7ghng17 214 30 inactivated inactivate VBN cord-269652-t7ghng17 214 31 polio polio NN cord-269652-t7ghng17 214 32 , , , cord-269652-t7ghng17 214 33 pneumococcal pneumococcal JJ cord-269652-t7ghng17 214 34 , , , cord-269652-t7ghng17 214 35 or or CC cord-269652-t7ghng17 214 36 rotavirus rotavirus JJ cord-269652-t7ghng17 214 37 vaccine vaccine NN cord-269652-t7ghng17 214 38 ) ) -RRB- cord-269652-t7ghng17 214 39 can can MD cord-269652-t7ghng17 214 40 be be VB cord-269652-t7ghng17 214 41 administered administer VBN cord-269652-t7ghng17 214 42 at at IN cord-269652-t7ghng17 214 43 a a DT cord-269652-t7ghng17 214 44 minimum minimum JJ cord-269652-t7ghng17 214 45 age age NN cord-269652-t7ghng17 214 46 of of IN cord-269652-t7ghng17 214 47 6 6 CD cord-269652-t7ghng17 214 48 weeks week NNS cord-269652-t7ghng17 214 49 . . . cord-269652-t7ghng17 215 1 53 53 CD cord-269652-t7ghng17 215 2 Care Care NNP cord-269652-t7ghng17 215 3 givers giver NNS cord-269652-t7ghng17 215 4 at at IN cord-269652-t7ghng17 215 5 home home NN cord-269652-t7ghng17 215 6 should should MD cord-269652-t7ghng17 215 7 be be VB cord-269652-t7ghng17 215 8 advised advise VBN cord-269652-t7ghng17 215 9 on on IN cord-269652-t7ghng17 215 10 the the DT cord-269652-t7ghng17 215 11 importance importance NN cord-269652-t7ghng17 215 12 of of IN cord-269652-t7ghng17 215 13 immunizing immunize VBG cord-269652-t7ghng17 215 14 family family NN cord-269652-t7ghng17 215 15 members member NNS cord-269652-t7ghng17 215 16 to to TO cord-269652-t7ghng17 215 17 protect protect VB cord-269652-t7ghng17 215 18 infants infant NNS cord-269652-t7ghng17 215 19 who who WP cord-269652-t7ghng17 215 20 are be VBP cord-269652-t7ghng17 215 21 too too RB cord-269652-t7ghng17 215 22 young young JJ cord-269652-t7ghng17 215 23 to to TO cord-269652-t7ghng17 215 24 be be VB cord-269652-t7ghng17 215 25 vaccinated vaccinate VBN cord-269652-t7ghng17 215 26 . . . cord-269652-t7ghng17 216 1 This this DT cord-269652-t7ghng17 216 2 is be VBZ cord-269652-t7ghng17 216 3 called call VBN cord-269652-t7ghng17 216 4 cocooning cocoon VBG cord-269652-t7ghng17 216 5 54 54 CD cord-269652-t7ghng17 216 6 and and CC cord-269652-t7ghng17 216 7 prevents prevent VBZ cord-269652-t7ghng17 216 8 vaccine vaccine NN cord-269652-t7ghng17 216 9 - - HYPH cord-269652-t7ghng17 216 10 preventable preventable JJ cord-269652-t7ghng17 216 11 diseases disease NNS cord-269652-t7ghng17 216 12 , , , cord-269652-t7ghng17 216 13 such such JJ cord-269652-t7ghng17 216 14 as as IN cord-269652-t7ghng17 216 15 pertussis pertussis NN cord-269652-t7ghng17 216 16 and and CC cord-269652-t7ghng17 216 17 influenza influenza NN cord-269652-t7ghng17 216 18 , , , cord-269652-t7ghng17 216 19 in in IN cord-269652-t7ghng17 216 20 young young JJ cord-269652-t7ghng17 216 21 infants infant NNS cord-269652-t7ghng17 216 22 . . . cord-269652-t7ghng17 217 1 Educational educational JJ cord-269652-t7ghng17 217 2 materials material NNS cord-269652-t7ghng17 217 3 on on IN cord-269652-t7ghng17 217 4 cocooning cocoon VBG cord-269652-t7ghng17 217 5 for for IN cord-269652-t7ghng17 217 6 parents parent NNS cord-269652-t7ghng17 217 7 and and CC cord-269652-t7ghng17 217 8 clinicians clinician NNS cord-269652-t7ghng17 217 9 are be VBP cord-269652-t7ghng17 217 10 available available JJ cord-269652-t7ghng17 217 11 at at IN cord-269652-t7ghng17 217 12 the the DT cord-269652-t7ghng17 217 13 AAP AAP NNP cord-269652-t7ghng17 217 14 Web Web NNP cord-269652-t7ghng17 217 15 site site NN cord-269652-t7ghng17 217 16 http://www2.aap.org/immunization/families/ http://www2.aap.org/immunization/families/ NNP cord-269652-t7ghng17 217 17 cocooning.html cocooning.html NNP cord-269652-t7ghng17 217 18 . . . cord-269652-t7ghng17 218 1 In in IN cord-269652-t7ghng17 218 2 October October NNP cord-269652-t7ghng17 218 3 2012 2012 CD cord-269652-t7ghng17 218 4 , , , cord-269652-t7ghng17 218 5 the the DT cord-269652-t7ghng17 218 6 use use NN cord-269652-t7ghng17 218 7 of of IN cord-269652-t7ghng17 218 8 tetanus tetanus NN cord-269652-t7ghng17 218 9 toxoid toxoid NN cord-269652-t7ghng17 218 10 , , , cord-269652-t7ghng17 218 11 reduced reduce VBN cord-269652-t7ghng17 218 12 diphtheria diphtheria NN cord-269652-t7ghng17 218 13 toxoid toxoid NN cord-269652-t7ghng17 218 14 , , , cord-269652-t7ghng17 218 15 and and CC cord-269652-t7ghng17 218 16 acellular acellular JJ cord-269652-t7ghng17 218 17 pertussis pertussis NN cord-269652-t7ghng17 218 18 vaccine vaccine NN cord-269652-t7ghng17 218 19 ( ( -LRB- cord-269652-t7ghng17 218 20 Tdap Tdap NNP cord-269652-t7ghng17 218 21 ) ) -RRB- cord-269652-t7ghng17 218 22 during during IN cord-269652-t7ghng17 218 23 every every DT cord-269652-t7ghng17 218 24 pregnancy pregnancy NN cord-269652-t7ghng17 218 25 was be VBD cord-269652-t7ghng17 218 26 recommended recommend VBN cord-269652-t7ghng17 218 27 because because IN cord-269652-t7ghng17 218 28 of of IN cord-269652-t7ghng17 218 29 increasing increase VBG cord-269652-t7ghng17 218 30 cases case NNS cord-269652-t7ghng17 218 31 of of IN cord-269652-t7ghng17 218 32 pertussis pertussis NN cord-269652-t7ghng17 218 33 in in IN cord-269652-t7ghng17 218 34 young young JJ cord-269652-t7ghng17 218 35 infants infant NNS cord-269652-t7ghng17 218 36 in in IN cord-269652-t7ghng17 218 37 the the DT cord-269652-t7ghng17 218 38 recent recent JJ cord-269652-t7ghng17 218 39 years year NNS cord-269652-t7ghng17 218 40 . . . cord-269652-t7ghng17 219 1 55 55 CD cord-269652-t7ghng17 220 1 The the DT cord-269652-t7ghng17 220 2 mother mother NN cord-269652-t7ghng17 220 3 's 's POS cord-269652-t7ghng17 220 4 protective protective JJ cord-269652-t7ghng17 220 5 antibodies antibody NNS cord-269652-t7ghng17 220 6 against against IN cord-269652-t7ghng17 220 7 pertussis pertussis NN cord-269652-t7ghng17 220 8 are be VBP cord-269652-t7ghng17 220 9 short short RB cord-269652-t7ghng17 220 10 - - HYPH cord-269652-t7ghng17 220 11 lived live VBN cord-269652-t7ghng17 220 12 and and CC cord-269652-t7ghng17 220 13 a a DT cord-269652-t7ghng17 220 14 dose dose NN cord-269652-t7ghng17 220 15 of of IN cord-269652-t7ghng17 220 16 Tdap Tdap NNP cord-269652-t7ghng17 220 17 in in IN cord-269652-t7ghng17 220 18 a a DT cord-269652-t7ghng17 220 19 previous previous JJ cord-269652-t7ghng17 220 20 pregnancy pregnancy NN cord-269652-t7ghng17 220 21 may may MD cord-269652-t7ghng17 220 22 not not RB cord-269652-t7ghng17 220 23 be be VB cord-269652-t7ghng17 220 24 protective protective JJ cord-269652-t7ghng17 220 25 to to IN cord-269652-t7ghng17 220 26 the the DT cord-269652-t7ghng17 220 27 infants infant NNS cord-269652-t7ghng17 220 28 of of IN cord-269652-t7ghng17 220 29 subsequent subsequent JJ cord-269652-t7ghng17 220 30 pregnancies pregnancy NNS cord-269652-t7ghng17 220 31 . . . cord-269652-t7ghng17 221 1 56 56 CD cord-269652-t7ghng17 221 2 Young young JJ cord-269652-t7ghng17 221 3 preterm preterm JJ cord-269652-t7ghng17 221 4 infants infant NNS cord-269652-t7ghng17 221 5 ( ( -LRB- cord-269652-t7ghng17 221 6 < < NNP cord-269652-t7ghng17 221 7 1 1 CD cord-269652-t7ghng17 221 8 year year NN cord-269652-t7ghng17 221 9 of of IN cord-269652-t7ghng17 221 10 age age NN cord-269652-t7ghng17 221 11 born bear VBN cord-269652-t7ghng17 221 12 at at IN cord-269652-t7ghng17 221 13 < < NNP cord-269652-t7ghng17 221 14 29 29 CD cord-269652-t7ghng17 221 15 weeks week NNS cord-269652-t7ghng17 221 16 and and CC cord-269652-t7ghng17 221 17 0-day 0-day JJ cord-269652-t7ghng17 221 18 gestation gestation NN cord-269652-t7ghng17 221 19 ) ) -RRB- cord-269652-t7ghng17 221 20 should should MD cord-269652-t7ghng17 221 21 receive receive VB cord-269652-t7ghng17 221 22 palivizumab palivizumab NNS cord-269652-t7ghng17 221 23 during during IN cord-269652-t7ghng17 221 24 the the DT cord-269652-t7ghng17 221 25 RSV RSV NNP cord-269652-t7ghng17 221 26 season season NN cord-269652-t7ghng17 221 27 for for IN cord-269652-t7ghng17 221 28 immunoprophylaxis immunoprophylaxis NNP cord-269652-t7ghng17 221 29 . . . cord-269652-t7ghng17 222 1 57 57 CD cord-269652-t7ghng17 223 1 Five five CD cord-269652-t7ghng17 223 2 monthly monthly JJ cord-269652-t7ghng17 223 3 doses dose NNS cord-269652-t7ghng17 223 4 of of IN cord-269652-t7ghng17 223 5 palivizumab palivizumab NNS cord-269652-t7ghng17 223 6 at at IN cord-269652-t7ghng17 223 7 15 15 CD cord-269652-t7ghng17 223 8 mg mg NNP cord-269652-t7ghng17 223 9 / / SYM cord-269652-t7ghng17 223 10 kg kg NNS cord-269652-t7ghng17 223 11 given give VBN cord-269652-t7ghng17 223 12 intramuscularly intramuscularly RB cord-269652-t7ghng17 223 13 will will MD cord-269652-t7ghng17 223 14 provide provide VB cord-269652-t7ghng17 223 15 adequate adequate JJ cord-269652-t7ghng17 223 16 protection protection NN cord-269652-t7ghng17 223 17 for for IN cord-269652-t7ghng17 223 18 6 6 CD cord-269652-t7ghng17 223 19 months month NNS cord-269652-t7ghng17 223 20 . . . cord-269652-t7ghng17 224 1 Other other JJ cord-269652-t7ghng17 224 2 indications indication NNS cord-269652-t7ghng17 224 3 during during IN cord-269652-t7ghng17 224 4 the the DT cord-269652-t7ghng17 224 5 RSV RSV NNP cord-269652-t7ghng17 224 6 season season NN cord-269652-t7ghng17 224 7 include include VBP cord-269652-t7ghng17 224 8 preterm preterm JJR cord-269652-t7ghng17 224 9 infants infant NNS cord-269652-t7ghng17 224 10 ( ( -LRB- cord-269652-t7ghng17 224 11 < < NNP cord-269652-t7ghng17 224 12 1 1 CD cord-269652-t7ghng17 224 13 year year NN cord-269652-t7ghng17 224 14 of of IN cord-269652-t7ghng17 224 15 age age NN cord-269652-t7ghng17 224 16 born bear VBN cord-269652-t7ghng17 224 17 at at IN cord-269652-t7ghng17 224 18 < < XX cord-269652-t7ghng17 224 19 32 32 CD cord-269652-t7ghng17 224 20 weeks week NNS cord-269652-t7ghng17 224 21 and and CC cord-269652-t7ghng17 224 22 0-day 0-day JJ cord-269652-t7ghng17 224 23 gestation gestation NN cord-269652-t7ghng17 224 24 ) ) -RRB- cord-269652-t7ghng17 224 25 with with IN cord-269652-t7ghng17 224 26 chronic chronic JJ cord-269652-t7ghng17 224 27 lung lung NN cord-269652-t7ghng17 224 28 disease disease NN cord-269652-t7ghng17 224 29 of of IN cord-269652-t7ghng17 224 30 prematurity prematurity NN cord-269652-t7ghng17 224 31 who who WP cord-269652-t7ghng17 224 32 required require VBD cord-269652-t7ghng17 224 33 greater great JJR cord-269652-t7ghng17 224 34 than than IN cord-269652-t7ghng17 224 35 21 21 CD cord-269652-t7ghng17 224 36 % % NN cord-269652-t7ghng17 224 37 oxygen oxygen NN cord-269652-t7ghng17 224 38 for for IN cord-269652-t7ghng17 224 39 at at IN cord-269652-t7ghng17 224 40 least least JJS cord-269652-t7ghng17 224 41 the the DT cord-269652-t7ghng17 224 42 first first JJ cord-269652-t7ghng17 224 43 28 28 CD cord-269652-t7ghng17 224 44 days day NNS cord-269652-t7ghng17 224 45 of of IN cord-269652-t7ghng17 224 46 life life NN cord-269652-t7ghng17 224 47 and and CC cord-269652-t7ghng17 224 48 young young JJ cord-269652-t7ghng17 224 49 infants infant NNS cord-269652-t7ghng17 224 50 ( ( -LRB- cord-269652-t7ghng17 224 51 < < NNP cord-269652-t7ghng17 224 52 1 1 CD cord-269652-t7ghng17 224 53 year year NN cord-269652-t7ghng17 224 54 of of IN cord-269652-t7ghng17 224 55 age age NN cord-269652-t7ghng17 224 56 ) ) -RRB- cord-269652-t7ghng17 224 57 with with IN cord-269652-t7ghng17 224 58 certain certain JJ cord-269652-t7ghng17 224 59 hemodynamically hemodynamically RB cord-269652-t7ghng17 224 60 significant significant JJ cord-269652-t7ghng17 224 61 heart heart NN cord-269652-t7ghng17 224 62 disease disease NN cord-269652-t7ghng17 224 63 . . . cord-269652-t7ghng17 225 1 57 57 CD cord-269652-t7ghng17 225 2 Clinicians clinician NNS cord-269652-t7ghng17 225 3 should should MD cord-269652-t7ghng17 225 4 consult consult VB cord-269652-t7ghng17 225 5 the the DT cord-269652-t7ghng17 225 6 most most RBS cord-269652-t7ghng17 225 7 current current JJ cord-269652-t7ghng17 225 8 guidelines guideline NNS cord-269652-t7ghng17 225 9 or or CC cord-269652-t7ghng17 225 10 policy policy NN cord-269652-t7ghng17 225 11 statement statement NN cord-269652-t7ghng17 225 12 from from IN cord-269652-t7ghng17 225 13 the the DT cord-269652-t7ghng17 225 14 AAP AAP NNP cord-269652-t7ghng17 225 15 regarding regard VBG cord-269652-t7ghng17 225 16 palivizumab palivizumab NNP cord-269652-t7ghng17 225 17 prophylaxis prophylaxis NN cord-269652-t7ghng17 225 18 among among IN cord-269652-t7ghng17 225 19 young young JJ cord-269652-t7ghng17 225 20 children child NNS cord-269652-t7ghng17 225 21 at at IN cord-269652-t7ghng17 225 22 increased increase VBN cord-269652-t7ghng17 225 23 risk risk NN cord-269652-t7ghng17 225 24 for for IN cord-269652-t7ghng17 225 25 hospitalization hospitalization NN cord-269652-t7ghng17 225 26 for for IN cord-269652-t7ghng17 225 27 RSV RSV NNP cord-269652-t7ghng17 225 28 infection infection NN cord-269652-t7ghng17 225 29 . . . cord-269652-t7ghng17 226 1 Injudicious injudicious JJ cord-269652-t7ghng17 226 2 use use NN cord-269652-t7ghng17 226 3 of of IN cord-269652-t7ghng17 226 4 antibiotics antibiotic NNS cord-269652-t7ghng17 226 5 can can MD cord-269652-t7ghng17 226 6 alter alter VB cord-269652-t7ghng17 226 7 the the DT cord-269652-t7ghng17 226 8 neonates neonate NNS cord-269652-t7ghng17 226 9 ' ' POS cord-269652-t7ghng17 226 10 microflora microflora NN cord-269652-t7ghng17 226 11 that that WDT cord-269652-t7ghng17 226 12 increases increase VBZ cord-269652-t7ghng17 226 13 exposure exposure NN cord-269652-t7ghng17 226 14 and and CC cord-269652-t7ghng17 226 15 pressure pressure NN cord-269652-t7ghng17 226 16 that that WDT cord-269652-t7ghng17 226 17 leads lead VBZ cord-269652-t7ghng17 226 18 to to IN cord-269652-t7ghng17 226 19 antimicrobial antimicrobial JJ cord-269652-t7ghng17 226 20 resistance resistance NN cord-269652-t7ghng17 226 21 . . . cord-269652-t7ghng17 227 1 The the DT cord-269652-t7ghng17 227 2 NICU NICU NNP cord-269652-t7ghng17 227 3 milieu milieu NN cord-269652-t7ghng17 227 4 and and CC cord-269652-t7ghng17 227 5 interventions intervention NNS cord-269652-t7ghng17 227 6 are be VBP cord-269652-t7ghng17 227 7 permissive permissive JJ cord-269652-t7ghng17 227 8 for for IN cord-269652-t7ghng17 227 9 the the DT cord-269652-t7ghng17 227 10 development development NN cord-269652-t7ghng17 227 11 of of IN cord-269652-t7ghng17 227 12 antibiotic antibiotic JJ cord-269652-t7ghng17 227 13 - - HYPH cord-269652-t7ghng17 227 14 resistant resistant JJ cord-269652-t7ghng17 227 15 organisms organism NNS cord-269652-t7ghng17 227 16 . . . cord-269652-t7ghng17 228 1 48 48 CD cord-269652-t7ghng17 228 2 , , , cord-269652-t7ghng17 228 3 58 58 CD cord-269652-t7ghng17 229 1 The the DT cord-269652-t7ghng17 229 2 AAP AAP NNP cord-269652-t7ghng17 229 3 Committee Committee NNP cord-269652-t7ghng17 229 4 on on IN cord-269652-t7ghng17 229 5 Fetus Fetus NNP cord-269652-t7ghng17 229 6 and and CC cord-269652-t7ghng17 229 7 Newborn Newborn NNP cord-269652-t7ghng17 229 8 48 48 CD cord-269652-t7ghng17 229 9 have have VBP cord-269652-t7ghng17 229 10 listed list VBN cord-269652-t7ghng17 229 11 ASP ASP NNP cord-269652-t7ghng17 229 12 strategies strategy NNS cord-269652-t7ghng17 229 13 that that WDT cord-269652-t7ghng17 229 14 may may MD cord-269652-t7ghng17 229 15 be be VB cord-269652-t7ghng17 229 16 useful useful JJ cord-269652-t7ghng17 229 17 in in IN cord-269652-t7ghng17 229 18 the the DT cord-269652-t7ghng17 229 19 NICU NICU NNP cord-269652-t7ghng17 229 20 setting set VBG cord-269652-t7ghng17 229 21 based base VBN cord-269652-t7ghng17 229 22 on on IN cord-269652-t7ghng17 229 23 the the DT cord-269652-t7ghng17 229 24 guideline guideline NN cord-269652-t7ghng17 229 25 from from IN cord-269652-t7ghng17 229 26 the the DT cord-269652-t7ghng17 229 27 Infectious Infectious NNP cord-269652-t7ghng17 229 28 Diseases Diseases NNPS cord-269652-t7ghng17 229 29 Society Society NNP cord-269652-t7ghng17 229 30 of of IN cord-269652-t7ghng17 229 31 America America NNP cord-269652-t7ghng17 229 32 and and CC cord-269652-t7ghng17 229 33 the the DT cord-269652-t7ghng17 229 34 Society Society NNP cord-269652-t7ghng17 229 35 for for IN cord-269652-t7ghng17 229 36 Healthcare Healthcare NNP cord-269652-t7ghng17 229 37 Epidemiology Epidemiology NNP cord-269652-t7ghng17 229 38 of of IN cord-269652-t7ghng17 229 39 America America NNP cord-269652-t7ghng17 229 40 ( ( -LRB- cord-269652-t7ghng17 229 41 Box Box NNP cord-269652-t7ghng17 229 42 1 1 CD cord-269652-t7ghng17 229 43 ) ) -RRB- cord-269652-t7ghng17 229 44 . . . cord-269652-t7ghng17 230 1 59 59 CD cord-269652-t7ghng17 231 1 There there EX cord-269652-t7ghng17 231 2 is be VBZ cord-269652-t7ghng17 231 3 some some DT cord-269652-t7ghng17 231 4 medical medical JJ cord-269652-t7ghng17 231 5 evidence evidence NN cord-269652-t7ghng17 231 6 supporting support VBG cord-269652-t7ghng17 231 7 the the DT cord-269652-t7ghng17 231 8 use use NN cord-269652-t7ghng17 231 9 of of IN cord-269652-t7ghng17 231 10 probiotics probiotic NNS cord-269652-t7ghng17 231 11 in in IN cord-269652-t7ghng17 231 12 the the DT cord-269652-t7ghng17 231 13 prevention prevention NN cord-269652-t7ghng17 231 14 of of IN cord-269652-t7ghng17 231 15 NEC NEC NNP cord-269652-t7ghng17 231 16 in in IN cord-269652-t7ghng17 231 17 preterm preterm JJ cord-269652-t7ghng17 231 18 infants infant NNS cord-269652-t7ghng17 231 19 . . . cord-269652-t7ghng17 232 1 Probiotic Probiotic NNP cord-269652-t7ghng17 232 2 is be VBZ cord-269652-t7ghng17 232 3 an an DT cord-269652-t7ghng17 232 4 oral oral JJ cord-269652-t7ghng17 232 5 supplement supplement NN cord-269652-t7ghng17 232 6 containing contain VBG cord-269652-t7ghng17 232 7 sufficient sufficient JJ cord-269652-t7ghng17 232 8 amount amount NN cord-269652-t7ghng17 232 9 of of IN cord-269652-t7ghng17 232 10 viable viable JJ cord-269652-t7ghng17 232 11 microorganisms microorganism NNS cord-269652-t7ghng17 232 12 that that WDT cord-269652-t7ghng17 232 13 alters alter VBZ cord-269652-t7ghng17 232 14 the the DT cord-269652-t7ghng17 232 15 host host NN cord-269652-t7ghng17 232 16 microflora microflora NN cord-269652-t7ghng17 232 17 with with IN cord-269652-t7ghng17 232 18 potential potential NN cord-269652-t7ghng17 232 19 for for IN cord-269652-t7ghng17 232 20 health health NN cord-269652-t7ghng17 232 21 benefits benefit NNS cord-269652-t7ghng17 232 22 . . . cord-269652-t7ghng17 233 1 60 60 CD cord-269652-t7ghng17 234 1 A a DT cord-269652-t7ghng17 234 2 meta meta JJ cord-269652-t7ghng17 234 3 - - HYPH cord-269652-t7ghng17 234 4 analysis analysis NN cord-269652-t7ghng17 234 5 based base VBN cord-269652-t7ghng17 234 6 on on IN cord-269652-t7ghng17 234 7 9 9 CD cord-269652-t7ghng17 234 8 randomized randomized JJ cord-269652-t7ghng17 234 9 control control NN cord-269652-t7ghng17 234 10 trials trial NNS cord-269652-t7ghng17 234 11 involving involve VBG cord-269652-t7ghng17 234 12 approximately approximately RB cord-269652-t7ghng17 234 13 1400 1400 CD cord-269652-t7ghng17 234 14 infants infant NNS cord-269652-t7ghng17 234 15 born bear VBN cord-269652-t7ghng17 234 16 before before IN cord-269652-t7ghng17 234 17 or or CC cord-269652-t7ghng17 234 18 at at IN cord-269652-t7ghng17 234 19 37 37 CD cord-269652-t7ghng17 234 20 weeks week NNS cord-269652-t7ghng17 234 21 gestation gestation NN cord-269652-t7ghng17 234 22 and/or and/or CC cord-269652-t7ghng17 234 23 weighing weigh VBG cord-269652-t7ghng17 234 24 less less JJR cord-269652-t7ghng17 234 25 than than IN cord-269652-t7ghng17 234 26 or or CC cord-269652-t7ghng17 234 27 equal equal JJ cord-269652-t7ghng17 234 28 to to IN cord-269652-t7ghng17 234 29 2500 2500 CD cord-269652-t7ghng17 234 30 g g NN cord-269652-t7ghng17 234 31 at at IN cord-269652-t7ghng17 234 32 birth birth NN cord-269652-t7ghng17 234 33 showed show VBD cord-269652-t7ghng17 234 34 that that IN cord-269652-t7ghng17 234 35 enteral enteral JJ cord-269652-t7ghng17 234 36 use use NN cord-269652-t7ghng17 234 37 of of IN cord-269652-t7ghng17 234 38 probiotic probiotic NN cord-269652-t7ghng17 234 39 significantly significantly RB cord-269652-t7ghng17 234 40 decreased decrease VBD cord-269652-t7ghng17 234 41 the the DT cord-269652-t7ghng17 234 42 incidence incidence NN cord-269652-t7ghng17 234 43 of of IN cord-269652-t7ghng17 234 44 severe severe JJ cord-269652-t7ghng17 234 45 NEC NEC NNP cord-269652-t7ghng17 234 46 and and CC cord-269652-t7ghng17 234 47 mortality mortality NN cord-269652-t7ghng17 234 48 . . . cord-269652-t7ghng17 235 1 61 61 CD cord-269652-t7ghng17 236 1 There there EX cord-269652-t7ghng17 236 2 were be VBD cord-269652-t7ghng17 236 3 no no DT cord-269652-t7ghng17 236 4 severe severe JJ cord-269652-t7ghng17 236 5 adverse adverse JJ cord-269652-t7ghng17 236 6 events event NNS cord-269652-t7ghng17 236 7 or or CC cord-269652-t7ghng17 236 8 systemic systemic JJ cord-269652-t7ghng17 236 9 infections infection NNS cord-269652-t7ghng17 236 10 directly directly RB cord-269652-t7ghng17 236 11 related relate VBN cord-269652-t7ghng17 236 12 to to IN cord-269652-t7ghng17 236 13 the the DT cord-269652-t7ghng17 236 14 probiotics probiotic NNS cord-269652-t7ghng17 236 15 used use VBN cord-269652-t7ghng17 236 16 were be VBD cord-269652-t7ghng17 236 17 reported report VBN cord-269652-t7ghng17 236 18 . . . cord-269652-t7ghng17 237 1 The the DT cord-269652-t7ghng17 237 2 AAP AAP NNP cord-269652-t7ghng17 237 3 Committee Committee NNP cord-269652-t7ghng17 237 4 on on IN cord-269652-t7ghng17 237 5 Nutrition Nutrition NNP cord-269652-t7ghng17 237 6 , , , cord-269652-t7ghng17 237 7 60 60 CD cord-269652-t7ghng17 237 8 however however RB cord-269652-t7ghng17 237 9 , , , cord-269652-t7ghng17 237 10 can can MD cord-269652-t7ghng17 237 11 not not RB cord-269652-t7ghng17 237 12 recommend recommend VB cord-269652-t7ghng17 237 13 the the DT cord-269652-t7ghng17 237 14 use use NN cord-269652-t7ghng17 237 15 of of IN cord-269652-t7ghng17 237 16 all all DT cord-269652-t7ghng17 237 17 probiotics probiotic NNS cord-269652-t7ghng17 237 18 in in IN cord-269652-t7ghng17 237 19 young young JJ cord-269652-t7ghng17 237 20 infants infant NNS cord-269652-t7ghng17 237 21 until until IN cord-269652-t7ghng17 237 22 further further JJ cord-269652-t7ghng17 237 23 studies study NNS cord-269652-t7ghng17 237 24 are be VBP cord-269652-t7ghng17 237 25 done do VBN cord-269652-t7ghng17 237 26 to to TO cord-269652-t7ghng17 237 27 resolve resolve VB cord-269652-t7ghng17 237 28 problematic problematic JJ cord-269652-t7ghng17 237 29 issues issue NNS cord-269652-t7ghng17 237 30 . . . cord-269652-t7ghng17 238 1 They -PRON- PRP cord-269652-t7ghng17 238 2 noted note VBD cord-269652-t7ghng17 238 3 the the DT cord-269652-t7ghng17 238 4 large large JJ cord-269652-t7ghng17 238 5 heterogeneity heterogeneity NN cord-269652-t7ghng17 238 6 of of IN cord-269652-t7ghng17 238 7 the the DT cord-269652-t7ghng17 238 8 studies study NNS cord-269652-t7ghng17 238 9 included include VBN cord-269652-t7ghng17 238 10 in in IN cord-269652-t7ghng17 238 11 the the DT cord-269652-t7ghng17 238 12 review review NN cord-269652-t7ghng17 238 13 , , , cord-269652-t7ghng17 238 14 the the DT cord-269652-t7ghng17 238 15 different different JJ cord-269652-t7ghng17 238 16 mixture mixture NN cord-269652-t7ghng17 238 17 of of IN cord-269652-t7ghng17 238 18 probiotics probiotic NNS cord-269652-t7ghng17 238 19 used use VBN cord-269652-t7ghng17 238 20 , , , cord-269652-t7ghng17 238 21 and and CC cord-269652-t7ghng17 238 22 that that IN cord-269652-t7ghng17 238 23 the the DT cord-269652-t7ghng17 238 24 combinations combination NNS cord-269652-t7ghng17 238 25 of of IN cord-269652-t7ghng17 238 26 probiotics probiotic NNS cord-269652-t7ghng17 238 27 used use VBN cord-269652-t7ghng17 238 28 in in IN cord-269652-t7ghng17 238 29 the the DT cord-269652-t7ghng17 238 30 studies study NNS cord-269652-t7ghng17 238 31 are be VBP cord-269652-t7ghng17 238 32 not not RB cord-269652-t7ghng17 238 33 available available JJ cord-269652-t7ghng17 238 34 in in IN cord-269652-t7ghng17 238 35 the the DT cord-269652-t7ghng17 238 36 United United NNP cord-269652-t7ghng17 238 37 States States NNP cord-269652-t7ghng17 238 38 . . . cord-269652-t7ghng17 239 1 Further further RB cord-269652-t7ghng17 239 2 , , , cord-269652-t7ghng17 239 3 there there EX cord-269652-t7ghng17 239 4 remains remain VBZ cord-269652-t7ghng17 239 5 some some DT cord-269652-t7ghng17 239 6 gap gap NN cord-269652-t7ghng17 239 7 in in IN cord-269652-t7ghng17 239 8 knowledge knowledge NN cord-269652-t7ghng17 239 9 on on IN cord-269652-t7ghng17 239 10 which which WDT cord-269652-t7ghng17 239 11 probiotic probiotic JJ cord-269652-t7ghng17 239 12 bacteria bacteria NNS cord-269652-t7ghng17 239 13 species specie NNS cord-269652-t7ghng17 239 14 to to TO cord-269652-t7ghng17 239 15 use use VB cord-269652-t7ghng17 239 16 , , , cord-269652-t7ghng17 239 17 the the DT cord-269652-t7ghng17 239 18 microbial microbial JJ cord-269652-t7ghng17 239 19 dose dose NN cord-269652-t7ghng17 239 20 , , , cord-269652-t7ghng17 239 21 as as RB cord-269652-t7ghng17 239 22 well well RB cord-269652-t7ghng17 239 23 as as IN cord-269652-t7ghng17 239 24 the the DT cord-269652-t7ghng17 239 25 duration duration NN cord-269652-t7ghng17 239 26 of of IN cord-269652-t7ghng17 239 27 administration administration NN cord-269652-t7ghng17 239 28 . . . cord-269652-t7ghng17 240 1 In in IN cord-269652-t7ghng17 240 2 2014 2014 CD cord-269652-t7ghng17 240 3 , , , cord-269652-t7ghng17 240 4 an an DT cord-269652-t7ghng17 240 5 updated update VBN cord-269652-t7ghng17 240 6 review review NN cord-269652-t7ghng17 240 7 of of IN cord-269652-t7ghng17 240 8 the the DT cord-269652-t7ghng17 240 9 aforementioned aforementioned JJ cord-269652-t7ghng17 240 10 meta meta NNP cord-269652-t7ghng17 240 11 - - HYPH cord-269652-t7ghng17 240 12 analysis analysis NN cord-269652-t7ghng17 240 13 of of IN cord-269652-t7ghng17 240 14 randomized randomized JJ cord-269652-t7ghng17 240 15 controlled control VBN cord-269652-t7ghng17 240 16 trials trial NNS cord-269652-t7ghng17 240 17 continues continue VBZ cord-269652-t7ghng17 240 18 to to TO cord-269652-t7ghng17 240 19 support support VB cord-269652-t7ghng17 240 20 a a DT cord-269652-t7ghng17 240 21 change change NN cord-269652-t7ghng17 240 22 in in IN cord-269652-t7ghng17 240 23 practice practice NN cord-269652-t7ghng17 240 24 of of IN cord-269652-t7ghng17 240 25 supplementing supplement VBG cord-269652-t7ghng17 240 26 preterm preterm JJR cord-269652-t7ghng17 240 27 infants infant NNS cord-269652-t7ghng17 240 28 with with IN cord-269652-t7ghng17 240 29 probiotics probiotic NNS cord-269652-t7ghng17 240 30 . . . cord-269652-t7ghng17 241 1 The the DT cord-269652-t7ghng17 241 2 review review NN cord-269652-t7ghng17 241 3 provided provide VBD cord-269652-t7ghng17 241 4 similar similar JJ cord-269652-t7ghng17 241 5 results result NNS cord-269652-t7ghng17 241 6 involving involve VBG cord-269652-t7ghng17 241 7 more more JJR cord-269652-t7ghng17 241 8 than than IN cord-269652-t7ghng17 241 9 5000 5000 CD cord-269652-t7ghng17 241 10 infants infant NNS cord-269652-t7ghng17 241 11 in in IN cord-269652-t7ghng17 241 12 whom whom WP cord-269652-t7ghng17 241 13 probiotics probiotics VBP cord-269652-t7ghng17 241 14 significantly significantly RB cord-269652-t7ghng17 241 15 reduced reduce VBD cord-269652-t7ghng17 241 16 severe severe JJ cord-269652-t7ghng17 241 17 NEC nec NN cord-269652-t7ghng17 241 18 and and CC cord-269652-t7ghng17 241 19 mortality mortality NN cord-269652-t7ghng17 241 20 . . . cord-269652-t7ghng17 242 1 62 62 CD cord-269652-t7ghng17 243 1 However however RB cord-269652-t7ghng17 243 2 , , , cord-269652-t7ghng17 243 3 the the DT cord-269652-t7ghng17 243 4 previously previously RB cord-269652-t7ghng17 243 5 mentioned mention VBN cord-269652-t7ghng17 243 6 gap gap NN cord-269652-t7ghng17 243 7 in in IN cord-269652-t7ghng17 243 8 knowledge knowledge NN cord-269652-t7ghng17 243 9 remains remain VBZ cord-269652-t7ghng17 243 10 , , , cord-269652-t7ghng17 243 11 as as RB cord-269652-t7ghng17 243 12 well well RB cord-269652-t7ghng17 243 13 as as IN cord-269652-t7ghng17 243 14 the the DT cord-269652-t7ghng17 243 15 need need NN cord-269652-t7ghng17 243 16 for for IN cord-269652-t7ghng17 243 17 comparative comparative JJ cord-269652-t7ghng17 243 18 studies study NNS cord-269652-t7ghng17 243 19 . . . cord-269652-t7ghng17 244 1 There there EX cord-269652-t7ghng17 244 2 is be VBZ cord-269652-t7ghng17 244 3 scarcity scarcity NN cord-269652-t7ghng17 244 4 of of IN cord-269652-t7ghng17 244 5 medical medical JJ cord-269652-t7ghng17 244 6 evidence evidence NN cord-269652-t7ghng17 244 7 to to TO cord-269652-t7ghng17 244 8 recommend recommend VB cord-269652-t7ghng17 244 9 the the DT cord-269652-t7ghng17 244 10 addition addition NN cord-269652-t7ghng17 244 11 of of IN cord-269652-t7ghng17 244 12 prebiotics prebiotic NNS cord-269652-t7ghng17 244 13 such such JJ cord-269652-t7ghng17 244 14 as as IN cord-269652-t7ghng17 244 15 oligosaccharides oligosaccharide NNS cord-269652-t7ghng17 244 16 in in IN cord-269652-t7ghng17 244 17 infant infant NN cord-269652-t7ghng17 244 18 formula formula NN cord-269652-t7ghng17 244 19 . . . cord-269652-t7ghng17 245 1 Prebiotics Prebiotics NNP cord-269652-t7ghng17 245 2 are be VBP cord-269652-t7ghng17 245 3 nondigestible nondigestible JJ cord-269652-t7ghng17 245 4 food food NN cord-269652-t7ghng17 245 5 ingredients ingredient NNS cord-269652-t7ghng17 245 6 that that WDT cord-269652-t7ghng17 245 7 occur occur VBP cord-269652-t7ghng17 245 8 naturally naturally RB cord-269652-t7ghng17 245 9 or or CC cord-269652-t7ghng17 245 10 as as IN cord-269652-t7ghng17 245 11 dietary dietary JJ cord-269652-t7ghng17 245 12 supplements supplement NNS cord-269652-t7ghng17 245 13 that that WDT cord-269652-t7ghng17 245 14 enhance enhance VBP cord-269652-t7ghng17 245 15 growth growth NN cord-269652-t7ghng17 245 16 of of IN cord-269652-t7ghng17 245 17 probiotic probiotic JJ cord-269652-t7ghng17 245 18 bacteria bacteria NNS cord-269652-t7ghng17 245 19 such such JJ cord-269652-t7ghng17 245 20 as as IN cord-269652-t7ghng17 245 21 Bifidobacterium Bifidobacterium NNP cord-269652-t7ghng17 245 22 spp spp NNS cord-269652-t7ghng17 245 23 . . . cord-269652-t7ghng17 246 1 60 60 CD cord-269652-t7ghng17 247 1 Several several JJ cord-269652-t7ghng17 247 2 studies study NNS cord-269652-t7ghng17 247 3 had have VBD cord-269652-t7ghng17 247 4 reported report VBN cord-269652-t7ghng17 247 5 that that IN cord-269652-t7ghng17 247 6 the the DT cord-269652-t7ghng17 247 7 addition addition NN cord-269652-t7ghng17 247 8 of of IN cord-269652-t7ghng17 247 9 prebiotics prebiotic NNS cord-269652-t7ghng17 247 10 in in IN cord-269652-t7ghng17 247 11 infant infant NN cord-269652-t7ghng17 247 12 formula formula NN cord-269652-t7ghng17 247 13 significantly significantly RB cord-269652-t7ghng17 247 14 increased increase VBD cord-269652-t7ghng17 247 15 the the DT cord-269652-t7ghng17 247 16 bifidobacteria bifidobacteria NNP cord-269652-t7ghng17 247 17 counts count VBZ cord-269652-t7ghng17 247 18 in in IN cord-269652-t7ghng17 247 19 their -PRON- PRP$ cord-269652-t7ghng17 247 20 stool stool NN cord-269652-t7ghng17 247 21 without without IN cord-269652-t7ghng17 247 22 adverse adverse JJ cord-269652-t7ghng17 247 23 effects effect NNS cord-269652-t7ghng17 247 24 noted note VBN cord-269652-t7ghng17 247 25 . . . cord-269652-t7ghng17 248 1 However however RB cord-269652-t7ghng17 248 2 , , , cord-269652-t7ghng17 248 3 clinical clinical JJ cord-269652-t7ghng17 248 4 efficacy efficacy NN cord-269652-t7ghng17 248 5 as as RB cord-269652-t7ghng17 248 6 well well RB cord-269652-t7ghng17 248 7 as as IN cord-269652-t7ghng17 248 8 cost cost NN cord-269652-t7ghng17 248 9 - - HYPH cord-269652-t7ghng17 248 10 benefit benefit NN cord-269652-t7ghng17 248 11 analyses analysis NNS cord-269652-t7ghng17 248 12 regarding regard VBG cord-269652-t7ghng17 248 13 the the DT cord-269652-t7ghng17 248 14 addition addition NN cord-269652-t7ghng17 248 15 of of IN cord-269652-t7ghng17 248 16 oligosaccharides oligosaccharide NNS cord-269652-t7ghng17 248 17 to to IN cord-269652-t7ghng17 248 18 infant infant NN cord-269652-t7ghng17 248 19 formulas formula NNS cord-269652-t7ghng17 248 20 is be VBZ cord-269652-t7ghng17 248 21 lacking lack VBG cord-269652-t7ghng17 248 22 . . . cord-269652-t7ghng17 249 1 60 60 CD cord-269652-t7ghng17 250 1 For for IN cord-269652-t7ghng17 250 2 infants infant NNS cord-269652-t7ghng17 250 3 , , , cord-269652-t7ghng17 250 4 human human JJ cord-269652-t7ghng17 250 5 milk milk NN cord-269652-t7ghng17 250 6 remains remain VBZ cord-269652-t7ghng17 250 7 the the DT cord-269652-t7ghng17 250 8 best good JJS cord-269652-t7ghng17 250 9 source source NN cord-269652-t7ghng17 250 10 of of IN cord-269652-t7ghng17 250 11 naturally naturally RB cord-269652-t7ghng17 250 12 occurring occur VBG cord-269652-t7ghng17 250 13 prebiotics prebiotic NNS cord-269652-t7ghng17 250 14 and and CC cord-269652-t7ghng17 250 15 probiotics probiotic NNS cord-269652-t7ghng17 250 16 , , , cord-269652-t7ghng17 250 17 and and CC cord-269652-t7ghng17 250 18 immunoprotective immunoprotective JJ cord-269652-t7ghng17 250 19 compounds compound NNS cord-269652-t7ghng17 250 20 known know VBN cord-269652-t7ghng17 250 21 to to TO cord-269652-t7ghng17 250 22 decrease decrease VB cord-269652-t7ghng17 250 23 the the DT cord-269652-t7ghng17 250 24 incidence incidence NN cord-269652-t7ghng17 250 25 of of IN cord-269652-t7ghng17 250 26 respiratory respiratory JJ cord-269652-t7ghng17 250 27 and and CC cord-269652-t7ghng17 250 28 gastrointestinal gastrointestinal JJ cord-269652-t7ghng17 250 29 infections infection NNS cord-269652-t7ghng17 250 30 . . . cord-269652-t7ghng17 251 1 48 48 CD cord-269652-t7ghng17 251 2 , , , cord-269652-t7ghng17 251 3 60 60 CD cord-269652-t7ghng17 251 4 Nursery Nursery NNP cord-269652-t7ghng17 251 5 Intensive Intensive NNP cord-269652-t7ghng17 251 6 Care Care NNP cord-269652-t7ghng17 251 7 Unit Unit NNP cord-269652-t7ghng17 251 8 Care Care NNP cord-269652-t7ghng17 251 9 Bundles bundle NNS cord-269652-t7ghng17 252 1 There there EX cord-269652-t7ghng17 252 2 are be VBP cord-269652-t7ghng17 252 3 invasive invasive JJ cord-269652-t7ghng17 252 4 procedures procedure NNS cord-269652-t7ghng17 252 5 that that WDT cord-269652-t7ghng17 252 6 may may MD cord-269652-t7ghng17 252 7 increase increase VB cord-269652-t7ghng17 252 8 the the DT cord-269652-t7ghng17 252 9 infant infant NN cord-269652-t7ghng17 252 10 's 's POS cord-269652-t7ghng17 252 11 risk risk NN cord-269652-t7ghng17 252 12 of of IN cord-269652-t7ghng17 252 13 health health NN cord-269652-t7ghng17 252 14 care care NN cord-269652-t7ghng17 252 15 - - HYPH cord-269652-t7ghng17 252 16 associated associate VBN cord-269652-t7ghng17 252 17 infections infection NNS cord-269652-t7ghng17 252 18 in in IN cord-269652-t7ghng17 252 19 the the DT cord-269652-t7ghng17 252 20 NICU NICU NNP cord-269652-t7ghng17 252 21 setting setting NN cord-269652-t7ghng17 252 22 . . . cord-269652-t7ghng17 253 1 These these DT cord-269652-t7ghng17 253 2 infections infection NNS cord-269652-t7ghng17 253 3 include include VBP cord-269652-t7ghng17 253 4 central central JJ cord-269652-t7ghng17 253 5 line line NN cord-269652-t7ghng17 253 6 - - HYPH cord-269652-t7ghng17 253 7 associated associate VBN cord-269652-t7ghng17 253 8 BSIs bsi NNS cord-269652-t7ghng17 253 9 ( ( -LRB- cord-269652-t7ghng17 253 10 CLABSIs CLABSIs NNP cord-269652-t7ghng17 253 11 ) ) -RRB- cord-269652-t7ghng17 253 12 , , , cord-269652-t7ghng17 253 13 pneumonia pneumonia NN cord-269652-t7ghng17 253 14 , , , cord-269652-t7ghng17 253 15 skin skin NN cord-269652-t7ghng17 253 16 , , , cord-269652-t7ghng17 253 17 and and CC cord-269652-t7ghng17 253 18 soft soft JJ cord-269652-t7ghng17 253 19 tissue tissue NN cord-269652-t7ghng17 253 20 infections infection NNS cord-269652-t7ghng17 253 21 ; ; : cord-269652-t7ghng17 253 22 and and CC cord-269652-t7ghng17 253 23 , , , cord-269652-t7ghng17 253 24 occasionally occasionally RB cord-269652-t7ghng17 253 25 , , , cord-269652-t7ghng17 253 26 vaccine vaccine NN cord-269652-t7ghng17 253 27 - - HYPH cord-269652-t7ghng17 253 28 preventable preventable JJ cord-269652-t7ghng17 253 29 diseases disease NNS cord-269652-t7ghng17 253 30 and and CC cord-269652-t7ghng17 253 31 outbreak outbreak NN cord-269652-t7ghng17 253 32 of of IN cord-269652-t7ghng17 253 33 respiratory respiratory JJ cord-269652-t7ghng17 253 34 viral viral JJ cord-269652-t7ghng17 253 35 infections infection NNS cord-269652-t7ghng17 253 36 . . . cord-269652-t7ghng17 254 1 Care care NN cord-269652-t7ghng17 254 2 bundles bundle NNS cord-269652-t7ghng17 254 3 are be VBP cord-269652-t7ghng17 254 4 sets set NNS cord-269652-t7ghng17 254 5 of of IN cord-269652-t7ghng17 254 6 interventions intervention NNS cord-269652-t7ghng17 254 7 aimed aim VBN cord-269652-t7ghng17 254 8 at at IN cord-269652-t7ghng17 254 9 reducing reduce VBG cord-269652-t7ghng17 254 10 health health NN cord-269652-t7ghng17 254 11 care care NN cord-269652-t7ghng17 254 12 - - HYPH cord-269652-t7ghng17 254 13 associated associate VBN cord-269652-t7ghng17 254 14 infections infection NNS cord-269652-t7ghng17 254 15 in in IN cord-269652-t7ghng17 254 16 the the DT cord-269652-t7ghng17 254 17 NICU NICU NNP cord-269652-t7ghng17 254 18 . . . cord-269652-t7ghng17 255 1 48 48 CD cord-269652-t7ghng17 256 1 The the DT cord-269652-t7ghng17 256 2 most most RBS cord-269652-t7ghng17 256 3 common common JJ cord-269652-t7ghng17 256 4 cause cause NN cord-269652-t7ghng17 256 5 of of IN cord-269652-t7ghng17 256 6 CLABSI CLABSI NNP cord-269652-t7ghng17 256 7 48 48 CD cord-269652-t7ghng17 256 8 and and CC cord-269652-t7ghng17 256 9 LOS LOS NNP cord-269652-t7ghng17 256 10 8 8 CD cord-269652-t7ghng17 256 11 are be VBP cord-269652-t7ghng17 256 12 coagulase coagulase NN cord-269652-t7ghng17 256 13 - - HYPH cord-269652-t7ghng17 256 14 negative negative JJ cord-269652-t7ghng17 256 15 staphylococci staphylococcus NNS cord-269652-t7ghng17 256 16 . . . cord-269652-t7ghng17 257 1 Several several JJ cord-269652-t7ghng17 257 2 randomized randomized JJ cord-269652-t7ghng17 257 3 clinical clinical JJ cord-269652-t7ghng17 257 4 trials trial NNS cord-269652-t7ghng17 257 5 on on IN cord-269652-t7ghng17 257 6 the the DT cord-269652-t7ghng17 257 7 use use NN cord-269652-t7ghng17 257 8 of of IN cord-269652-t7ghng17 257 9 low low JJ cord-269652-t7ghng17 257 10 - - HYPH cord-269652-t7ghng17 257 11 dose dose NN cord-269652-t7ghng17 257 12 vancomycin vancomycin NN cord-269652-t7ghng17 257 13 in in IN cord-269652-t7ghng17 257 14 parenteral parenteral JJ cord-269652-t7ghng17 257 15 solutions solution NNS cord-269652-t7ghng17 257 16 in in IN cord-269652-t7ghng17 257 17 preterm preterm JJ cord-269652-t7ghng17 257 18 infants infant NNS cord-269652-t7ghng17 257 19 did do VBD cord-269652-t7ghng17 257 20 not not RB cord-269652-t7ghng17 257 21 show show VB cord-269652-t7ghng17 257 22 significant significant JJ cord-269652-t7ghng17 257 23 decrease decrease NN cord-269652-t7ghng17 257 24 in in IN cord-269652-t7ghng17 257 25 the the DT cord-269652-t7ghng17 257 26 length length NN cord-269652-t7ghng17 257 27 of of IN cord-269652-t7ghng17 257 28 stay stay NN cord-269652-t7ghng17 257 29 and and CC cord-269652-t7ghng17 257 30 mortality mortality NN cord-269652-t7ghng17 257 31 . . . cord-269652-t7ghng17 258 1 48 48 CD cord-269652-t7ghng17 259 1 There there EX cord-269652-t7ghng17 259 2 is be VBZ cord-269652-t7ghng17 259 3 an an DT cord-269652-t7ghng17 259 4 antibiotic antibiotic JJ cord-269652-t7ghng17 259 5 - - HYPH cord-269652-t7ghng17 259 6 lock lock NN cord-269652-t7ghng17 259 7 therapy therapy NN cord-269652-t7ghng17 259 8 done do VBN cord-269652-t7ghng17 259 9 in in IN cord-269652-t7ghng17 259 10 neonates neonate NNS cord-269652-t7ghng17 259 11 that that WDT cord-269652-t7ghng17 259 12 significantly significantly RB cord-269652-t7ghng17 259 13 decrease decrease VBP cord-269652-t7ghng17 259 14 CLABSI CLABSI NNP cord-269652-t7ghng17 259 15 however however RB cord-269652-t7ghng17 259 16 it -PRON- PRP cord-269652-t7ghng17 259 17 was be VBD cord-269652-t7ghng17 259 18 not not RB cord-269652-t7ghng17 259 19 powered power VBN cord-269652-t7ghng17 259 20 to to TO cord-269652-t7ghng17 259 21 answer answer VB cord-269652-t7ghng17 259 22 whether whether IN cord-269652-t7ghng17 259 23 vancomycin vancomycin NN cord-269652-t7ghng17 259 24 resistance resistance NN cord-269652-t7ghng17 259 25 occurred occur VBD cord-269652-t7ghng17 259 26 . . . cord-269652-t7ghng17 260 1 Both both DT cord-269652-t7ghng17 260 2 are be VBP cord-269652-t7ghng17 260 3 currently currently RB cord-269652-t7ghng17 260 4 not not RB cord-269652-t7ghng17 260 5 recommended recommend VBN cord-269652-t7ghng17 260 6 because because IN cord-269652-t7ghng17 260 7 of of IN cord-269652-t7ghng17 260 8 the the DT cord-269652-t7ghng17 260 9 lack lack NN cord-269652-t7ghng17 260 10 of of IN cord-269652-t7ghng17 260 11 long long JJ cord-269652-t7ghng17 260 12 - - HYPH cord-269652-t7ghng17 260 13 term term NN cord-269652-t7ghng17 260 14 efficacy efficacy NN cord-269652-t7ghng17 260 15 evidence evidence NN cord-269652-t7ghng17 260 16 as as RB cord-269652-t7ghng17 260 17 well well RB cord-269652-t7ghng17 260 18 as as IN cord-269652-t7ghng17 260 19 concern concern NN cord-269652-t7ghng17 260 20 for for IN cord-269652-t7ghng17 260 21 development development NN cord-269652-t7ghng17 260 22 of of IN cord-269652-t7ghng17 260 23 drug drug NN cord-269652-t7ghng17 260 24 - - HYPH cord-269652-t7ghng17 260 25 resistant resistant JJ cord-269652-t7ghng17 260 26 organisms organism NNS cord-269652-t7ghng17 260 27 . . . cord-269652-t7ghng17 261 1 Infection infection NN cord-269652-t7ghng17 261 2 control control NN cord-269652-t7ghng17 261 3 intended intend VBN cord-269652-t7ghng17 261 4 to to TO cord-269652-t7ghng17 261 5 decrease decrease VB cord-269652-t7ghng17 261 6 CLABSI CLABSI NNP cord-269652-t7ghng17 261 7 in in IN cord-269652-t7ghng17 261 8 the the DT cord-269652-t7ghng17 261 9 NICU NICU NNP cord-269652-t7ghng17 261 10 should should MD cord-269652-t7ghng17 261 11 include include VB cord-269652-t7ghng17 261 12 measures measure NNS cord-269652-t7ghng17 261 13 to to TO cord-269652-t7ghng17 261 14 decrease decrease VB cord-269652-t7ghng17 261 15 extraluminal extraluminal JJ cord-269652-t7ghng17 261 16 and and CC cord-269652-t7ghng17 261 17 intravascular intravascular JJ cord-269652-t7ghng17 261 18 catheter catheter NN cord-269652-t7ghng17 261 19 - - HYPH cord-269652-t7ghng17 261 20 related relate VBN cord-269652-t7ghng17 261 21 infections infection NNS cord-269652-t7ghng17 261 22 . . . cord-269652-t7ghng17 262 1 Various various JJ cord-269652-t7ghng17 262 2 techniques technique NNS cord-269652-t7ghng17 262 3 and and CC cord-269652-t7ghng17 262 4 guidelines guideline NNS cord-269652-t7ghng17 262 5 in in IN cord-269652-t7ghng17 262 6 the the DT cord-269652-t7ghng17 262 7 prevention prevention NN cord-269652-t7ghng17 262 8 of of IN cord-269652-t7ghng17 262 9 CLABSI CLABSI NNP cord-269652-t7ghng17 262 10 in in IN cord-269652-t7ghng17 262 11 infants infant NNS cord-269652-t7ghng17 262 12 adapted adapt VBN cord-269652-t7ghng17 262 13 from from IN cord-269652-t7ghng17 262 14 the the DT cord-269652-t7ghng17 262 15 AAP AAP NNP cord-269652-t7ghng17 262 16 Committee Committee NNP cord-269652-t7ghng17 262 17 on on IN cord-269652-t7ghng17 262 18 Fetus Fetus NNP cord-269652-t7ghng17 262 19 and and CC cord-269652-t7ghng17 262 20 Newborn Newborn NNP cord-269652-t7ghng17 262 21 are be VBP cord-269652-t7ghng17 262 22 shown show VBN cord-269652-t7ghng17 262 23 in in IN cord-269652-t7ghng17 262 24 Box Box NNP cord-269652-t7ghng17 262 25 2 2 CD cord-269652-t7ghng17 262 26 . . . cord-269652-t7ghng17 263 1 48 48 CD cord-269652-t7ghng17 264 1 There there EX cord-269652-t7ghng17 264 2 are be VBP cord-269652-t7ghng17 264 3 specific specific JJ cord-269652-t7ghng17 264 4 practices practice NNS cord-269652-t7ghng17 264 5 that that WDT cord-269652-t7ghng17 264 6 may may MD cord-269652-t7ghng17 264 7 be be VB cord-269652-t7ghng17 264 8 adapted adapt VBN cord-269652-t7ghng17 264 9 in in IN cord-269652-t7ghng17 264 10 the the DT cord-269652-t7ghng17 264 11 local local JJ cord-269652-t7ghng17 264 12 setting setting NN cord-269652-t7ghng17 264 13 for for IN cord-269652-t7ghng17 264 14 preventing prevent VBG cord-269652-t7ghng17 264 15 vaccine vaccine NN cord-269652-t7ghng17 264 16 - - HYPH cord-269652-t7ghng17 264 17 preventable preventable JJ cord-269652-t7ghng17 264 18 diseases disease NNS cord-269652-t7ghng17 264 19 and and CC cord-269652-t7ghng17 264 20 outbreaks outbreak NNS cord-269652-t7ghng17 264 21 of of IN cord-269652-t7ghng17 264 22 respiratory respiratory JJ cord-269652-t7ghng17 264 23 viral viral JJ cord-269652-t7ghng17 264 24 infections infection NNS cord-269652-t7ghng17 264 25 . . . cord-269652-t7ghng17 265 1 These these DT cord-269652-t7ghng17 265 2 include include VBP cord-269652-t7ghng17 265 3 but but CC cord-269652-t7ghng17 265 4 are be VBP cord-269652-t7ghng17 265 5 not not RB cord-269652-t7ghng17 265 6 limited limited JJ cord-269652-t7ghng17 265 7 to to IN cord-269652-t7ghng17 265 8 vaccination vaccination NN cord-269652-t7ghng17 265 9 of of IN cord-269652-t7ghng17 265 10 health health NN cord-269652-t7ghng17 265 11 care care NN cord-269652-t7ghng17 265 12 providers provider NNS cord-269652-t7ghng17 265 13 against against IN cord-269652-t7ghng17 265 14 influenza influenza NN cord-269652-t7ghng17 265 15 and and CC cord-269652-t7ghng17 265 16 pertussis pertussis NN cord-269652-t7ghng17 265 17 ( ( -LRB- cord-269652-t7ghng17 265 18 Tdap Tdap NNP cord-269652-t7ghng17 265 19 ) ) -RRB- cord-269652-t7ghng17 265 20 , , , cord-269652-t7ghng17 265 21 visitation visitation NN cord-269652-t7ghng17 265 22 guidelines guideline NNS cord-269652-t7ghng17 265 23 to to TO cord-269652-t7ghng17 265 24 screen screen VB cord-269652-t7ghng17 265 25 ill ill JJ cord-269652-t7ghng17 265 26 or or CC cord-269652-t7ghng17 265 27 symptomatic symptomatic JJ cord-269652-t7ghng17 265 28 visitors visitor NNS cord-269652-t7ghng17 265 29 , , , cord-269652-t7ghng17 265 30 and and CC cord-269652-t7ghng17 265 31 cohorting cohorte VBG cord-269652-t7ghng17 265 32 in in IN cord-269652-t7ghng17 265 33 cases case NNS cord-269652-t7ghng17 265 34 of of IN cord-269652-t7ghng17 265 35 clustering clustering NN cord-269652-t7ghng17 265 36 of of IN cord-269652-t7ghng17 265 37 infections infection NNS cord-269652-t7ghng17 265 38 or or CC cord-269652-t7ghng17 265 39 in in IN cord-269652-t7ghng17 265 40 outbreak outbreak NN cord-269652-t7ghng17 265 41 situations situation NNS cord-269652-t7ghng17 265 42 . . . cord-269652-t7ghng17 266 1 48 48 CD cord-269652-t7ghng17 267 1 Cohorting Cohorting NNP cord-269652-t7ghng17 267 2 may may MD cord-269652-t7ghng17 267 3 only only RB cord-269652-t7ghng17 267 4 be be VB cord-269652-t7ghng17 267 5 possible possible JJ cord-269652-t7ghng17 267 6 if if IN cord-269652-t7ghng17 267 7 early early JJ cord-269652-t7ghng17 267 8 screening screening NN cord-269652-t7ghng17 267 9 procedures procedure NNS cord-269652-t7ghng17 267 10 , , , cord-269652-t7ghng17 267 11 such such JJ cord-269652-t7ghng17 267 12 as as IN cord-269652-t7ghng17 267 13 the the DT cord-269652-t7ghng17 267 14 use use NN cord-269652-t7ghng17 267 15 of of IN cord-269652-t7ghng17 267 16 PCR PCR NNP cord-269652-t7ghng17 267 17 - - HYPH cord-269652-t7ghng17 267 18 based base VBN cord-269652-t7ghng17 267 19 assays assay NNS cord-269652-t7ghng17 267 20 , , , cord-269652-t7ghng17 267 21 are be VBP cord-269652-t7ghng17 267 22 in in IN cord-269652-t7ghng17 267 23 place place NN cord-269652-t7ghng17 267 24 if if IN cord-269652-t7ghng17 267 25 available available JJ cord-269652-t7ghng17 267 26 in in IN cord-269652-t7ghng17 267 27 cases case NNS cord-269652-t7ghng17 267 28 of of IN cord-269652-t7ghng17 267 29 clustering clustering NN cord-269652-t7ghng17 267 30 of of IN cord-269652-t7ghng17 267 31 respiratory respiratory JJ cord-269652-t7ghng17 267 32 viral viral JJ cord-269652-t7ghng17 267 33 infections infection NNS cord-269652-t7ghng17 267 34 . . . cord-269652-t7ghng17 268 1 [ [ -LRB- cord-269652-t7ghng17 268 2 14 14 CD cord-269652-t7ghng17 268 3 ] ] -RRB- cord-269652-t7ghng17 268 4 [ [ -LRB- cord-269652-t7ghng17 268 5 15 15 CD cord-269652-t7ghng17 268 6 ] ] -RRB- cord-269652-t7ghng17 269 1 [ [ -LRB- cord-269652-t7ghng17 269 2 16 16 CD cord-269652-t7ghng17 269 3 ] ] -RRB- cord-269652-t7ghng17 270 1 Further further RB cord-269652-t7ghng17 270 2 , , , cord-269652-t7ghng17 270 3 appropriate appropriate JJ cord-269652-t7ghng17 270 4 isolation isolation NN cord-269652-t7ghng17 270 5 ( ( -LRB- cord-269652-t7ghng17 270 6 eg eg IN cord-269652-t7ghng17 270 7 , , , cord-269652-t7ghng17 270 8 contact contact NN cord-269652-t7ghng17 270 9 precautions precaution NNS cord-269652-t7ghng17 270 10 for for IN cord-269652-t7ghng17 270 11 MRSA MRSA NNP cord-269652-t7ghng17 270 12 , , , cord-269652-t7ghng17 270 13 droplet droplet NN cord-269652-t7ghng17 270 14 precautions precaution NNS cord-269652-t7ghng17 270 15 for for IN cord-269652-t7ghng17 270 16 influenza influenza NN cord-269652-t7ghng17 270 17 , , , cord-269652-t7ghng17 270 18 and and CC cord-269652-t7ghng17 270 19 airborne airborne JJ cord-269652-t7ghng17 270 20 precautions precaution NNS cord-269652-t7ghng17 270 21 for for IN cord-269652-t7ghng17 270 22 measles measle NNS cord-269652-t7ghng17 270 23 ) ) -RRB- cord-269652-t7ghng17 270 24 should should MD cord-269652-t7ghng17 270 25 be be VB cord-269652-t7ghng17 270 26 observed observe VBN cord-269652-t7ghng17 270 27 if if IN cord-269652-t7ghng17 270 28 the the DT cord-269652-t7ghng17 270 29 infant infant NN cord-269652-t7ghng17 270 30 is be VBZ cord-269652-t7ghng17 270 31 Clean clean JJ cord-269652-t7ghng17 270 32 the the DT cord-269652-t7ghng17 270 33 umbilical umbilical JJ cord-269652-t7ghng17 270 34 insertion insertion NN cord-269652-t7ghng17 270 35 site site NN cord-269652-t7ghng17 270 36 using use VBG cord-269652-t7ghng17 270 37 an an DT cord-269652-t7ghng17 270 38 antiseptic antiseptic JJ cord-269652-t7ghng17 270 39 such such JJ cord-269652-t7ghng17 270 40 as as IN cord-269652-t7ghng17 270 41 povidone povidone NN cord-269652-t7ghng17 270 42 - - HYPH cord-269652-t7ghng17 270 43 iodine iodine NN cord-269652-t7ghng17 270 44 before before IN cord-269652-t7ghng17 270 45 catheter catheter NN cord-269652-t7ghng17 270 46 insertion insertion NN cord-269652-t7ghng17 270 47 . . . cord-269652-t7ghng17 271 1 Avoid avoid VB cord-269652-t7ghng17 271 2 using use VBG cord-269652-t7ghng17 271 3 topical topical JJ cord-269652-t7ghng17 271 4 antibiotic antibiotic JJ cord-269652-t7ghng17 271 5 ointment ointment NN cord-269652-t7ghng17 271 6 or or CC cord-269652-t7ghng17 271 7 creams cream NNS cord-269652-t7ghng17 271 8 on on IN cord-269652-t7ghng17 271 9 insertion insertion NN cord-269652-t7ghng17 271 10 sites site NNS cord-269652-t7ghng17 271 11 to to TO cord-269652-t7ghng17 271 12 prevent prevent VB cord-269652-t7ghng17 271 13 fungal fungal JJ cord-269652-t7ghng17 271 14 infections infection NNS cord-269652-t7ghng17 271 15 and and CC cord-269652-t7ghng17 271 16 antimicrobial antimicrobial JJ cord-269652-t7ghng17 271 17 resistance resistance NN cord-269652-t7ghng17 271 18 . . . cord-269652-t7ghng17 272 1 Use use VB cord-269652-t7ghng17 272 2 low low JJ cord-269652-t7ghng17 272 3 doses dose NNS cord-269652-t7ghng17 272 4 of of IN cord-269652-t7ghng17 272 5 heparin heparin NN cord-269652-t7ghng17 272 6 ( ( -LRB- cord-269652-t7ghng17 272 7 0.25 0.25 CD cord-269652-t7ghng17 272 8 - - SYM cord-269652-t7ghng17 272 9 1.0 1.0 CD cord-269652-t7ghng17 272 10 U u NN cord-269652-t7ghng17 272 11 / / SYM cord-269652-t7ghng17 272 12 mL ml NN cord-269652-t7ghng17 272 13 ) ) -RRB- cord-269652-t7ghng17 272 14 to to IN cord-269652-t7ghng17 272 15 the the DT cord-269652-t7ghng17 272 16 fluid fluid NN cord-269652-t7ghng17 272 17 infused infuse VBN cord-269652-t7ghng17 272 18 through through IN cord-269652-t7ghng17 272 19 umbilical umbilical JJ cord-269652-t7ghng17 272 20 arterial arterial JJ cord-269652-t7ghng17 272 21 catheter catheter NN cord-269652-t7ghng17 272 22 . . . cord-269652-t7ghng17 273 1 Remove remove VB cord-269652-t7ghng17 273 2 umbilical umbilical JJ cord-269652-t7ghng17 273 3 catheters catheter NNS cord-269652-t7ghng17 273 4 as as RB cord-269652-t7ghng17 273 5 soon soon RB cord-269652-t7ghng17 273 6 as as IN cord-269652-t7ghng17 273 7 no no RB cord-269652-t7ghng17 273 8 longer long RBR cord-269652-t7ghng17 273 9 needed need VBN cord-269652-t7ghng17 273 10 or or CC cord-269652-t7ghng17 273 11 if if IN cord-269652-t7ghng17 273 12 signs sign NNS cord-269652-t7ghng17 273 13 of of IN cord-269652-t7ghng17 273 14 vascular vascular JJ cord-269652-t7ghng17 273 15 insufficiency insufficiency NN cord-269652-t7ghng17 273 16 to to IN cord-269652-t7ghng17 273 17 the the DT cord-269652-t7ghng17 273 18 lower low JJR cord-269652-t7ghng17 273 19 extremities extremity NNS cord-269652-t7ghng17 273 20 ( ( -LRB- cord-269652-t7ghng17 273 21 for for IN cord-269652-t7ghng17 273 22 umbilical umbilical JJ cord-269652-t7ghng17 273 23 artery artery NN cord-269652-t7ghng17 273 24 access access NN cord-269652-t7ghng17 273 25 ) ) -RRB- cord-269652-t7ghng17 273 26 are be VBP cord-269652-t7ghng17 273 27 present present JJ cord-269652-t7ghng17 273 28 ; ; : cord-269652-t7ghng17 273 29 they -PRON- PRP cord-269652-t7ghng17 273 30 may may MD cord-269652-t7ghng17 273 31 be be VB cord-269652-t7ghng17 273 32 replaced replace VBN cord-269652-t7ghng17 273 33 if if IN cord-269652-t7ghng17 273 34 malfunctioning malfunction VBG cord-269652-t7ghng17 273 35 . . . cord-269652-t7ghng17 274 1 Umbilical umbilical JJ cord-269652-t7ghng17 274 2 artery artery NN cord-269652-t7ghng17 274 3 catheters catheter NNS cord-269652-t7ghng17 274 4 should should MD cord-269652-t7ghng17 274 5 not not RB cord-269652-t7ghng17 274 6 be be VB cord-269652-t7ghng17 274 7 left leave VBN cord-269652-t7ghng17 274 8 in in IN cord-269652-t7ghng17 274 9 place place NN cord-269652-t7ghng17 274 10 for for IN cord-269652-t7ghng17 274 11 more more JJR cord-269652-t7ghng17 274 12 than than IN cord-269652-t7ghng17 274 13 5 5 CD cord-269652-t7ghng17 274 14 days day NNS cord-269652-t7ghng17 274 15 . . . cord-269652-t7ghng17 275 1 Umbilical umbilical JJ cord-269652-t7ghng17 275 2 venous venous JJ cord-269652-t7ghng17 275 3 catheters catheter NNS cord-269652-t7ghng17 275 4 may may MD cord-269652-t7ghng17 275 5 be be VB cord-269652-t7ghng17 275 6 used use VBN cord-269652-t7ghng17 275 7 up up IN cord-269652-t7ghng17 275 8 to to TO cord-269652-t7ghng17 275 9 14 14 CD cord-269652-t7ghng17 275 10 days day NNS cord-269652-t7ghng17 275 11 if if IN cord-269652-t7ghng17 275 12 managed manage VBN cord-269652-t7ghng17 275 13 aseptically aseptically RB cord-269652-t7ghng17 275 14 . . . cord-269652-t7ghng17 276 1 colonized colonize VBN cord-269652-t7ghng17 276 2 or or CC cord-269652-t7ghng17 276 3 infected infect VBN cord-269652-t7ghng17 276 4 with with IN cord-269652-t7ghng17 276 5 a a DT cord-269652-t7ghng17 276 6 pathogen pathogen NN cord-269652-t7ghng17 276 7 requiring require VBG cord-269652-t7ghng17 276 8 additional additional JJ cord-269652-t7ghng17 276 9 protection protection NN cord-269652-t7ghng17 276 10 beyond beyond IN cord-269652-t7ghng17 276 11 standard standard JJ cord-269652-t7ghng17 276 12 precautions precaution NNS cord-269652-t7ghng17 276 13 . . . cord-269652-t7ghng17 277 1 63 63 CD cord-269652-t7ghng17 277 2 _SP cord-269652-t7ghng17 277 3 Neonatal neonatal JJ cord-269652-t7ghng17 277 4 infections infection NNS cord-269652-t7ghng17 277 5 continue continue VBP cord-269652-t7ghng17 277 6 to to TO cord-269652-t7ghng17 277 7 cause cause VB cord-269652-t7ghng17 277 8 morbidity morbidity NN cord-269652-t7ghng17 277 9 and and CC cord-269652-t7ghng17 277 10 mortality mortality NN cord-269652-t7ghng17 277 11 in in IN cord-269652-t7ghng17 277 12 infants infant NNS cord-269652-t7ghng17 277 13 . . . cord-269652-t7ghng17 278 1 GBS GBS NNP cord-269652-t7ghng17 278 2 and and CC cord-269652-t7ghng17 278 3 E e NN cord-269652-t7ghng17 278 4 coli coli NNS cord-269652-t7ghng17 278 5 are be VBP cord-269652-t7ghng17 278 6 the the DT cord-269652-t7ghng17 278 7 most most RBS cord-269652-t7ghng17 278 8 common common JJ cord-269652-t7ghng17 278 9 agents agent NNS cord-269652-t7ghng17 278 10 of of IN cord-269652-t7ghng17 278 11 EOS EOS NNP cord-269652-t7ghng17 278 12 , , , cord-269652-t7ghng17 278 13 whereas whereas IN cord-269652-t7ghng17 278 14 coagulase coagulase NN cord-269652-t7ghng17 278 15 - - HYPH cord-269652-t7ghng17 278 16 negative negative JJ cord-269652-t7ghng17 278 17 Staphylococcus Staphylococcus NNP cord-269652-t7ghng17 278 18 is be VBZ cord-269652-t7ghng17 278 19 the the DT cord-269652-t7ghng17 278 20 predominant predominant JJ cord-269652-t7ghng17 278 21 cause cause NN cord-269652-t7ghng17 278 22 for for IN cord-269652-t7ghng17 278 23 LOS LOS NNP cord-269652-t7ghng17 278 24 . . . cord-269652-t7ghng17 279 1 There there EX cord-269652-t7ghng17 279 2 is be VBZ cord-269652-t7ghng17 279 3 increasing increase VBG cord-269652-t7ghng17 279 4 recognition recognition NN cord-269652-t7ghng17 279 5 of of IN cord-269652-t7ghng17 279 6 respiratory respiratory JJ cord-269652-t7ghng17 279 7 viral viral JJ cord-269652-t7ghng17 279 8 infections infection NNS cord-269652-t7ghng17 279 9 contributing contribute VBG cord-269652-t7ghng17 279 10 to to IN cord-269652-t7ghng17 279 11 ruling rule VBG cord-269652-t7ghng17 279 12 out out RP cord-269652-t7ghng17 279 13 sepsis sepsis NN cord-269652-t7ghng17 279 14 in in IN cord-269652-t7ghng17 279 15 very very RB cord-269652-t7ghng17 279 16 young young JJ cord-269652-t7ghng17 279 17 infants infant NNS cord-269652-t7ghng17 279 18 whose whose WP$ cord-269652-t7ghng17 279 19 presentations presentation NNS cord-269652-t7ghng17 279 20 are be VBP cord-269652-t7ghng17 279 21 similar similar JJ cord-269652-t7ghng17 279 22 to to IN cord-269652-t7ghng17 279 23 bacterial bacterial JJ cord-269652-t7ghng17 279 24 infections infection NNS cord-269652-t7ghng17 279 25 . . . cord-269652-t7ghng17 280 1 Blood blood NN cord-269652-t7ghng17 280 2 culture culture NN cord-269652-t7ghng17 280 3 at at IN cord-269652-t7ghng17 280 4 birth birth NN cord-269652-t7ghng17 280 5 and and CC cord-269652-t7ghng17 280 6 white white JJ cord-269652-t7ghng17 280 7 blood blood NN cord-269652-t7ghng17 280 8 cell cell NN cord-269652-t7ghng17 280 9 with with IN cord-269652-t7ghng17 280 10 or or CC cord-269652-t7ghng17 280 11 without without IN cord-269652-t7ghng17 280 12 CRP CRP NNP cord-269652-t7ghng17 280 13 has have VBZ cord-269652-t7ghng17 280 14 been be VBN cord-269652-t7ghng17 280 15 used use VBN cord-269652-t7ghng17 280 16 in in IN cord-269652-t7ghng17 280 17 the the DT cord-269652-t7ghng17 280 18 algorithm algorithm NN cord-269652-t7ghng17 280 19 - - HYPH cord-269652-t7ghng17 280 20 based base VBN cord-269652-t7ghng17 280 21 guideline guideline NN cord-269652-t7ghng17 280 22 for for IN cord-269652-t7ghng17 280 23 the the DT cord-269652-t7ghng17 280 24 evaluation evaluation NN cord-269652-t7ghng17 280 25 of of IN cord-269652-t7ghng17 280 26 asymptomatic asymptomatic JJ cord-269652-t7ghng17 280 27 term term NN cord-269652-t7ghng17 280 28 and and CC cord-269652-t7ghng17 280 29 preterm preterm JJ cord-269652-t7ghng17 280 30 infants infant NNS cord-269652-t7ghng17 280 31 with with IN cord-269652-t7ghng17 280 32 risk risk NN cord-269652-t7ghng17 280 33 factors factor NNS cord-269652-t7ghng17 280 34 for for IN cord-269652-t7ghng17 280 35 sepsis sepsis NN cord-269652-t7ghng17 280 36 . . . cord-269652-t7ghng17 281 1 Ampicillin Ampicillin NNP cord-269652-t7ghng17 281 2 and and CC cord-269652-t7ghng17 281 3 gentamicin gentamicin NN cord-269652-t7ghng17 281 4 remains remain VBZ cord-269652-t7ghng17 281 5 the the DT cord-269652-t7ghng17 281 6 cornerstone cornerstone NN cord-269652-t7ghng17 281 7 of of IN cord-269652-t7ghng17 281 8 initial initial JJ cord-269652-t7ghng17 281 9 antimicrobial antimicrobial JJ cord-269652-t7ghng17 281 10 regimen regimen NN cord-269652-t7ghng17 281 11 for for IN cord-269652-t7ghng17 281 12 neonatal neonatal JJ cord-269652-t7ghng17 281 13 infections infection NNS cord-269652-t7ghng17 281 14 . . . cord-269652-t7ghng17 282 1 Third third JJ cord-269652-t7ghng17 282 2 - - HYPH cord-269652-t7ghng17 282 3 generation generation NN cord-269652-t7ghng17 282 4 cephalosporins cephalosporin NNS cord-269652-t7ghng17 282 5 should should MD cord-269652-t7ghng17 282 6 be be VB cord-269652-t7ghng17 282 7 used use VBN cord-269652-t7ghng17 282 8 judiciously judiciously RB cord-269652-t7ghng17 282 9 . . . cord-269652-t7ghng17 283 1 The the DT cord-269652-t7ghng17 283 2 use use NN cord-269652-t7ghng17 283 3 of of IN cord-269652-t7ghng17 283 4 antiviral antiviral JJ cord-269652-t7ghng17 283 5 ( ( -LRB- cord-269652-t7ghng17 283 6 acyclovir acyclovir NNP cord-269652-t7ghng17 283 7 , , , cord-269652-t7ghng17 283 8 ganciclovir ganciclovir NNP cord-269652-t7ghng17 283 9 , , , cord-269652-t7ghng17 283 10 valganciclovir valganciclovir NNP cord-269652-t7ghng17 283 11 , , , cord-269652-t7ghng17 283 12 and and CC cord-269652-t7ghng17 283 13 oseltamivir oseltamivir NNP cord-269652-t7ghng17 283 14 ) ) -RRB- cord-269652-t7ghng17 283 15 and and CC cord-269652-t7ghng17 283 16 antifungal antifungal JJ cord-269652-t7ghng17 283 17 ( ( -LRB- cord-269652-t7ghng17 283 18 fluconazole fluconazole NN cord-269652-t7ghng17 283 19 , , , cord-269652-t7ghng17 283 20 amphotericin amphotericin NNS cord-269652-t7ghng17 283 21 B b NN cord-269652-t7ghng17 283 22 , , , cord-269652-t7ghng17 283 23 and and CC cord-269652-t7ghng17 283 24 voriconazole voriconazole NN cord-269652-t7ghng17 283 25 ) ) -RRB- cord-269652-t7ghng17 283 26 treatment treatment NN cord-269652-t7ghng17 283 27 and and CC cord-269652-t7ghng17 283 28 prophylactic prophylactic JJ cord-269652-t7ghng17 283 29 regimens regimen NNS cord-269652-t7ghng17 283 30 may may MD cord-269652-t7ghng17 283 31 reduce reduce VB cord-269652-t7ghng17 283 32 mortality mortality NN cord-269652-t7ghng17 283 33 and and CC cord-269652-t7ghng17 283 34 morbidity morbidity NN cord-269652-t7ghng17 283 35 to to IN cord-269652-t7ghng17 283 36 specific specific JJ cord-269652-t7ghng17 283 37 viral viral JJ cord-269652-t7ghng17 283 38 and and CC cord-269652-t7ghng17 283 39 fungal fungal JJ cord-269652-t7ghng17 283 40 disease disease NN cord-269652-t7ghng17 283 41 in in IN cord-269652-t7ghng17 283 42 infants infant NNS cord-269652-t7ghng17 283 43 . . . cord-269652-t7ghng17 284 1 There there EX cord-269652-t7ghng17 284 2 are be VBP cord-269652-t7ghng17 284 3 various various JJ cord-269652-t7ghng17 284 4 strategies strategy NNS cord-269652-t7ghng17 284 5 , , , cord-269652-t7ghng17 284 6 such such JJ cord-269652-t7ghng17 284 7 as as IN cord-269652-t7ghng17 284 8 GBS GBS NNP cord-269652-t7ghng17 284 9 prophylaxis prophylaxis NN cord-269652-t7ghng17 284 10 , , , cord-269652-t7ghng17 284 11 hand hand NN cord-269652-t7ghng17 284 12 hygiene hygiene NN cord-269652-t7ghng17 284 13 , , , cord-269652-t7ghng17 284 14 immunization immunization NN cord-269652-t7ghng17 284 15 , , , cord-269652-t7ghng17 284 16 and and CC cord-269652-t7ghng17 284 17 immunoprophylaxis immunoprophylaxis NNP cord-269652-t7ghng17 284 18 , , , cord-269652-t7ghng17 284 19 ASP ASP NNP cord-269652-t7ghng17 284 20 , , , cord-269652-t7ghng17 284 21 probiotics probiotic NNS cord-269652-t7ghng17 284 22 , , , cord-269652-t7ghng17 284 23 and and CC cord-269652-t7ghng17 284 24 prebiotics prebiotic NNS cord-269652-t7ghng17 284 25 , , , cord-269652-t7ghng17 284 26 and and CC cord-269652-t7ghng17 284 27 NICU NICU NNP cord-269652-t7ghng17 284 28 care care NN cord-269652-t7ghng17 284 29 bundles bundle NNS cord-269652-t7ghng17 284 30 , , , cord-269652-t7ghng17 284 31 which which WDT cord-269652-t7ghng17 284 32 may may MD cord-269652-t7ghng17 284 33 be be VB cord-269652-t7ghng17 284 34 used use VBN cord-269652-t7ghng17 284 35 in in IN cord-269652-t7ghng17 284 36 preventing prevent VBG cord-269652-t7ghng17 284 37 infections infection NNS cord-269652-t7ghng17 284 38 in in IN cord-269652-t7ghng17 284 39 infants infant NNS cord-269652-t7ghng17 284 40 . . . cord-269652-t7ghng17 285 1 Early early JJ cord-269652-t7ghng17 285 2 onset onset NN cord-269652-t7ghng17 285 3 neonatal neonatal JJ cord-269652-t7ghng17 285 4 sepsis sepsis NN cord-269652-t7ghng17 285 5 : : : cord-269652-t7ghng17 286 1 the the DT cord-269652-t7ghng17 286 2 burden burden NN cord-269652-t7ghng17 286 3 of of IN cord-269652-t7ghng17 286 4 group group NN cord-269652-t7ghng17 286 5 B B NNP cord-269652-t7ghng17 286 6 Streptococcal Streptococcal NNP cord-269652-t7ghng17 286 7 and and CC cord-269652-t7ghng17 286 8 E. E. NNP cord-269652-t7ghng17 286 9 coli coli VBZ cord-269652-t7ghng17 286 10 disease disease NN cord-269652-t7ghng17 286 11 continues continue VBZ cord-269652-t7ghng17 286 12 Neonatal neonatal JJ cord-269652-t7ghng17 286 13 infectious infectious JJ cord-269652-t7ghng17 286 14 diseases disease NNS cord-269652-t7ghng17 286 15 : : : cord-269652-t7ghng17 286 16 evaluation evaluation NN cord-269652-t7ghng17 286 17 of of IN cord-269652-t7ghng17 286 18 neonatal neonatal JJ cord-269652-t7ghng17 286 19 sepsis sepsis NN cord-269652-t7ghng17 287 1 The the DT cord-269652-t7ghng17 287 2 many many JJ cord-269652-t7ghng17 287 3 faces face NNS cord-269652-t7ghng17 287 4 of of IN cord-269652-t7ghng17 287 5 B b NN cord-269652-t7ghng17 287 6 cells cell NNS cord-269652-t7ghng17 287 7 : : : cord-269652-t7ghng17 287 8 from from IN cord-269652-t7ghng17 287 9 generation generation NN cord-269652-t7ghng17 287 10 of of IN cord-269652-t7ghng17 287 11 antibodies antibody NNS cord-269652-t7ghng17 287 12 to to TO cord-269652-t7ghng17 287 13 immune immune JJ cord-269652-t7ghng17 287 14 regulation regulation NN cord-269652-t7ghng17 287 15 Neonatal neonatal JJ cord-269652-t7ghng17 287 16 innate innate JJ cord-269652-t7ghng17 287 17 TLR tlr NN cord-269652-t7ghng17 287 18 - - HYPH cord-269652-t7ghng17 287 19 mediated mediate VBN cord-269652-t7ghng17 287 20 responses response NNS cord-269652-t7ghng17 287 21 are be VBP cord-269652-t7ghng17 287 22 distinct distinct JJ cord-269652-t7ghng17 287 23 from from IN cord-269652-t7ghng17 287 24 those those DT cord-269652-t7ghng17 287 25 of of IN cord-269652-t7ghng17 287 26 adults adult NNS cord-269652-t7ghng17 287 27 Innate innate JJ cord-269652-t7ghng17 287 28 immunity immunity NN cord-269652-t7ghng17 287 29 of of IN cord-269652-t7ghng17 287 30 the the DT cord-269652-t7ghng17 287 31 newborn newborn JJ cord-269652-t7ghng17 287 32 : : : cord-269652-t7ghng17 287 33 basic basic JJ cord-269652-t7ghng17 287 34 mechanisms mechanism NNS cord-269652-t7ghng17 287 35 and and CC cord-269652-t7ghng17 287 36 clinical clinical JJ cord-269652-t7ghng17 287 37 correlates correlate NNS cord-269652-t7ghng17 288 1 The the DT cord-269652-t7ghng17 288 2 neonatal neonatal JJ cord-269652-t7ghng17 288 3 adaptive adaptive JJ cord-269652-t7ghng17 288 4 immune immune NN cord-269652-t7ghng17 288 5 system system NN cord-269652-t7ghng17 288 6 Committee Committee NNP cord-269652-t7ghng17 288 7 on on IN cord-269652-t7ghng17 288 8 Fetus Fetus NNP cord-269652-t7ghng17 288 9 and and CC cord-269652-t7ghng17 288 10 Newborn Newborn NNP cord-269652-t7ghng17 288 11 . . . cord-269652-t7ghng17 289 1 Management management NN cord-269652-t7ghng17 289 2 of of IN cord-269652-t7ghng17 289 3 neonates neonate NNS cord-269652-t7ghng17 289 4 with with IN cord-269652-t7ghng17 289 5 suspected suspect VBN cord-269652-t7ghng17 289 6 or or CC cord-269652-t7ghng17 289 7 proven prove VBN cord-269652-t7ghng17 289 8 early early JJ cord-269652-t7ghng17 289 9 - - HYPH cord-269652-t7ghng17 289 10 onset onset NN cord-269652-t7ghng17 289 11 bacterial bacterial JJ cord-269652-t7ghng17 289 12 sepsis sepsis NN cord-269652-t7ghng17 289 13 Antibiotic antibiotic JJ cord-269652-t7ghng17 289 14 use use NN cord-269652-t7ghng17 289 15 and and CC cord-269652-t7ghng17 289 16 misuse misuse NN cord-269652-t7ghng17 289 17 in in IN cord-269652-t7ghng17 289 18 the the DT cord-269652-t7ghng17 289 19 neonatal neonatal JJ cord-269652-t7ghng17 289 20 intensive intensive JJ cord-269652-t7ghng17 289 21 care care NN cord-269652-t7ghng17 289 22 unit unit NN cord-269652-t7ghng17 290 1 The the DT cord-269652-t7ghng17 290 2 association association NN cord-269652-t7ghng17 290 3 of of IN cord-269652-t7ghng17 290 4 third third JJ cord-269652-t7ghng17 290 5 - - HYPH cord-269652-t7ghng17 290 6 generation generation NN cord-269652-t7ghng17 290 7 cephalosporin cephalosporin NN cord-269652-t7ghng17 290 8 use use NN cord-269652-t7ghng17 290 9 and and CC cord-269652-t7ghng17 290 10 invasive invasive JJ cord-269652-t7ghng17 290 11 candidiasis candidiasis NN cord-269652-t7ghng17 290 12 in in IN cord-269652-t7ghng17 290 13 extremely extremely RB cord-269652-t7ghng17 290 14 low low JJ cord-269652-t7ghng17 290 15 birth birth NN cord-269652-t7ghng17 290 16 - - HYPH cord-269652-t7ghng17 290 17 weight weight NN cord-269652-t7ghng17 290 18 infants infant NNS cord-269652-t7ghng17 291 1 Prolonged prolonged JJ cord-269652-t7ghng17 291 2 duration duration NN cord-269652-t7ghng17 291 3 of of IN cord-269652-t7ghng17 291 4 initial initial JJ cord-269652-t7ghng17 291 5 empirical empirical JJ cord-269652-t7ghng17 291 6 antibiotic antibiotic JJ cord-269652-t7ghng17 291 7 treatment treatment NN cord-269652-t7ghng17 291 8 is be VBZ cord-269652-t7ghng17 291 9 associated associate VBN cord-269652-t7ghng17 291 10 with with IN cord-269652-t7ghng17 291 11 increased increase VBN cord-269652-t7ghng17 291 12 rates rate NNS cord-269652-t7ghng17 291 13 of of IN cord-269652-t7ghng17 291 14 necrotizing necrotize VBG cord-269652-t7ghng17 291 15 enterocolitis enterocolitis NN cord-269652-t7ghng17 291 16 and and CC cord-269652-t7ghng17 291 17 death death NN cord-269652-t7ghng17 291 18 for for IN cord-269652-t7ghng17 291 19 extremely extremely RB cord-269652-t7ghng17 291 20 low low JJ cord-269652-t7ghng17 291 21 birth birth NN cord-269652-t7ghng17 291 22 weight weight NN cord-269652-t7ghng17 291 23 infants infant NNS cord-269652-t7ghng17 291 24 Prolonged prolong VBD cord-269652-t7ghng17 291 25 initial initial JJ cord-269652-t7ghng17 291 26 empirical empirical JJ cord-269652-t7ghng17 291 27 antibiotic antibiotic JJ cord-269652-t7ghng17 291 28 treatment treatment NN cord-269652-t7ghng17 291 29 is be VBZ cord-269652-t7ghng17 291 30 associated associate VBN cord-269652-t7ghng17 291 31 with with IN cord-269652-t7ghng17 291 32 adverse adverse JJ cord-269652-t7ghng17 291 33 outcomes outcome NNS cord-269652-t7ghng17 291 34 in in IN cord-269652-t7ghng17 291 35 premature premature JJ cord-269652-t7ghng17 291 36 infants infant NNS cord-269652-t7ghng17 291 37 Duration duration NN cord-269652-t7ghng17 291 38 of of IN cord-269652-t7ghng17 291 39 empiric empiric JJ cord-269652-t7ghng17 291 40 antibiotics antibiotic NNS cord-269652-t7ghng17 291 41 for for IN cord-269652-t7ghng17 291 42 suspected suspect VBN cord-269652-t7ghng17 291 43 early early JJ cord-269652-t7ghng17 291 44 - - HYPH cord-269652-t7ghng17 291 45 onset onset NN cord-269652-t7ghng17 291 46 sepsis sepsis NN cord-269652-t7ghng17 291 47 in in IN cord-269652-t7ghng17 291 48 extremely extremely RB cord-269652-t7ghng17 291 49 low low JJ cord-269652-t7ghng17 291 50 birth birth NN cord-269652-t7ghng17 291 51 weight weight NN cord-269652-t7ghng17 291 52 infants infant NNS cord-269652-t7ghng17 292 1 Clinical clinical JJ cord-269652-t7ghng17 292 2 utility utility NN cord-269652-t7ghng17 292 3 of of IN cord-269652-t7ghng17 292 4 PCR PCR NNP cord-269652-t7ghng17 292 5 for for IN cord-269652-t7ghng17 292 6 common common JJ cord-269652-t7ghng17 292 7 viruses virus NNS cord-269652-t7ghng17 292 8 in in IN cord-269652-t7ghng17 292 9 acute acute JJ cord-269652-t7ghng17 292 10 respiratory respiratory JJ cord-269652-t7ghng17 292 11 illness illness NN cord-269652-t7ghng17 293 1 Viral viral JJ cord-269652-t7ghng17 293 2 respiratory respiratory JJ cord-269652-t7ghng17 293 3 tract tract NN cord-269652-t7ghng17 293 4 infections infection NNS cord-269652-t7ghng17 293 5 in in IN cord-269652-t7ghng17 293 6 the the DT cord-269652-t7ghng17 293 7 neonatal neonatal JJ cord-269652-t7ghng17 293 8 intensive intensive JJ cord-269652-t7ghng17 293 9 care care NN cord-269652-t7ghng17 293 10 unit unit NN cord-269652-t7ghng17 293 11 : : : cord-269652-t7ghng17 294 1 the the DT cord-269652-t7ghng17 294 2 VIRIoN VIRIoN NNP cord-269652-t7ghng17 294 3 - - HYPH cord-269652-t7ghng17 294 4 I -PRON- PRP cord-269652-t7ghng17 294 5 study study VBP cord-269652-t7ghng17 294 6 Unrecognized unrecognized JJ cord-269652-t7ghng17 294 7 viral viral JJ cord-269652-t7ghng17 294 8 respiratory respiratory JJ cord-269652-t7ghng17 294 9 tract tract NN cord-269652-t7ghng17 294 10 infections infection NNS cord-269652-t7ghng17 294 11 in in IN cord-269652-t7ghng17 294 12 premature premature JJ cord-269652-t7ghng17 294 13 infants infant NNS cord-269652-t7ghng17 294 14 during during IN cord-269652-t7ghng17 294 15 their -PRON- PRP$ cord-269652-t7ghng17 294 16 birth birth NN cord-269652-t7ghng17 294 17 hospitalization hospitalization NN cord-269652-t7ghng17 294 18 : : : cord-269652-t7ghng17 294 19 a a DT cord-269652-t7ghng17 294 20 prospective prospective JJ cord-269652-t7ghng17 294 21 surveillance surveillance NN cord-269652-t7ghng17 294 22 study study NN cord-269652-t7ghng17 294 23 in in IN cord-269652-t7ghng17 294 24 two two CD cord-269652-t7ghng17 294 25 neonatal neonatal JJ cord-269652-t7ghng17 294 26 intensive intensive JJ cord-269652-t7ghng17 294 27 care care NN cord-269652-t7ghng17 294 28 units unit NNS cord-269652-t7ghng17 295 1 Nosocomial nosocomial JJ cord-269652-t7ghng17 295 2 rhinovirus rhinovirus NN cord-269652-t7ghng17 295 3 infection infection NN cord-269652-t7ghng17 295 4 in in IN cord-269652-t7ghng17 295 5 preterm preterm JJ cord-269652-t7ghng17 295 6 infants infant NNS cord-269652-t7ghng17 295 7 Principles principle NNS cord-269652-t7ghng17 295 8 and and CC cord-269652-t7ghng17 295 9 practice practice NN cord-269652-t7ghng17 295 10 of of IN cord-269652-t7ghng17 295 11 pediatric pediatric JJ cord-269652-t7ghng17 295 12 infectious infectious JJ cord-269652-t7ghng17 295 13 diseases disease NNS cord-269652-t7ghng17 296 1 Successful successful JJ cord-269652-t7ghng17 296 2 medical medical JJ cord-269652-t7ghng17 296 3 treatment treatment NN cord-269652-t7ghng17 296 4 of of IN cord-269652-t7ghng17 296 5 cutaneous cutaneous JJ cord-269652-t7ghng17 296 6 aspergillosis aspergillosis NN cord-269652-t7ghng17 296 7 in in IN cord-269652-t7ghng17 296 8 a a DT cord-269652-t7ghng17 296 9 premature premature JJ cord-269652-t7ghng17 296 10 infant infant NN cord-269652-t7ghng17 296 11 using use VBG cord-269652-t7ghng17 296 12 liposomal liposomal JJ cord-269652-t7ghng17 296 13 amphotericin amphotericin NNP cord-269652-t7ghng17 296 14 B B NNP cord-269652-t7ghng17 296 15 , , , cord-269652-t7ghng17 296 16 voriconazole voriconazole NNP cord-269652-t7ghng17 296 17 and and CC cord-269652-t7ghng17 296 18 micafungin micafungin NNP cord-269652-t7ghng17 296 19 Seventy Seventy NNP cord-269652-t7ghng17 296 20 - - HYPH cord-269652-t7ghng17 296 21 five five CD cord-269652-t7ghng17 296 22 years year NNS cord-269652-t7ghng17 296 23 of of IN cord-269652-t7ghng17 296 24 neonatal neonatal JJ cord-269652-t7ghng17 296 25 sepsis sepsis NN cord-269652-t7ghng17 296 26 at at IN cord-269652-t7ghng17 296 27 Yale Yale NNP cord-269652-t7ghng17 296 28 : : : cord-269652-t7ghng17 296 29 1928 1928 CD cord-269652-t7ghng17 296 30 - - SYM cord-269652-t7ghng17 296 31 2003 2003 CD cord-269652-t7ghng17 296 32 Neonatal neonatal JJ cord-269652-t7ghng17 296 33 sepsis sepsis NN cord-269652-t7ghng17 296 34 workups workup NNS cord-269652-t7ghng17 296 35 in in IN cord-269652-t7ghng17 296 36 infants infant NNS cord-269652-t7ghng17 296 37 > > XX cord-269652-t7ghng17 297 1 /52000 /52000 NFP cord-269652-t7ghng17 297 2 grams gram NNS cord-269652-t7ghng17 297 3 at at IN cord-269652-t7ghng17 297 4 birth birth NN cord-269652-t7ghng17 297 5 : : : cord-269652-t7ghng17 297 6 a a DT cord-269652-t7ghng17 297 7 population population NN cord-269652-t7ghng17 297 8 - - HYPH cord-269652-t7ghng17 297 9 based base VBN cord-269652-t7ghng17 297 10 study study NN cord-269652-t7ghng17 297 11 Principles principle NNS cord-269652-t7ghng17 297 12 and and CC cord-269652-t7ghng17 297 13 practice practice NN cord-269652-t7ghng17 297 14 of of IN cord-269652-t7ghng17 297 15 pediatric pediatric JJ cord-269652-t7ghng17 297 16 infectious infectious JJ cord-269652-t7ghng17 297 17 diseases disease NNS cord-269652-t7ghng17 298 1 Culture culture NN cord-269652-t7ghng17 298 2 negative negative JJ cord-269652-t7ghng17 298 3 sepsis sepsis NN cord-269652-t7ghng17 298 4 and and CC cord-269652-t7ghng17 298 5 systemic systemic JJ cord-269652-t7ghng17 298 6 inflammatory inflammatory JJ cord-269652-t7ghng17 298 7 response response NN cord-269652-t7ghng17 298 8 syndrome syndrome NN cord-269652-t7ghng17 298 9 in in IN cord-269652-t7ghng17 298 10 neonates neonate NNS cord-269652-t7ghng17 298 11 Utility Utility NNP cord-269652-t7ghng17 298 12 of of IN cord-269652-t7ghng17 298 13 complete complete JJ cord-269652-t7ghng17 298 14 blood blood NN cord-269652-t7ghng17 298 15 count count NN cord-269652-t7ghng17 298 16 and and CC cord-269652-t7ghng17 298 17 blood blood NN cord-269652-t7ghng17 298 18 culture culture NN cord-269652-t7ghng17 298 19 screening screening NN cord-269652-t7ghng17 298 20 to to TO cord-269652-t7ghng17 298 21 diagnose diagnose VB cord-269652-t7ghng17 298 22 neonatal neonatal JJ cord-269652-t7ghng17 298 23 sepsis sepsis NN cord-269652-t7ghng17 298 24 in in IN cord-269652-t7ghng17 298 25 the the DT cord-269652-t7ghng17 298 26 asymptomatic asymptomatic JJ cord-269652-t7ghng17 298 27 at at IN cord-269652-t7ghng17 298 28 risk risk NN cord-269652-t7ghng17 298 29 newborn newborn JJ cord-269652-t7ghng17 298 30 Effective effective JJ cord-269652-t7ghng17 298 31 biomarkers biomarker NNS cord-269652-t7ghng17 298 32 for for IN cord-269652-t7ghng17 298 33 diagnosis diagnosis NN cord-269652-t7ghng17 298 34 of of IN cord-269652-t7ghng17 298 35 neonatal neonatal JJ cord-269652-t7ghng17 298 36 sepsis sepsis NN cord-269652-t7ghng17 299 1 A a DT cord-269652-t7ghng17 299 2 guide guide NN cord-269652-t7ghng17 299 3 to to IN cord-269652-t7ghng17 299 4 utilization utilization NN cord-269652-t7ghng17 299 5 of of IN cord-269652-t7ghng17 299 6 the the DT cord-269652-t7ghng17 299 7 microbiology microbiology NN cord-269652-t7ghng17 299 8 laboratory laboratory NN cord-269652-t7ghng17 299 9 for for IN cord-269652-t7ghng17 299 10 diagnosis diagnosis NN cord-269652-t7ghng17 299 11 of of IN cord-269652-t7ghng17 299 12 infectious infectious JJ cord-269652-t7ghng17 299 13 diseases disease NNS cord-269652-t7ghng17 299 14 : : : cord-269652-t7ghng17 299 15 2013 2013 CD cord-269652-t7ghng17 299 16 recommendations recommendation NNS cord-269652-t7ghng17 299 17 by by IN cord-269652-t7ghng17 299 18 the the DT cord-269652-t7ghng17 299 19 Infectious Infectious NNP cord-269652-t7ghng17 299 20 Diseases Diseases NNPS cord-269652-t7ghng17 299 21 Society Society NNP cord-269652-t7ghng17 299 22 of of IN cord-269652-t7ghng17 299 23 America America NNP cord-269652-t7ghng17 299 24 ( ( -LRB- cord-269652-t7ghng17 299 25 IDSA IDSA NNP cord-269652-t7ghng17 299 26 ) ) -RRB- cord-269652-t7ghng17 299 27 and and CC cord-269652-t7ghng17 299 28 the the DT cord-269652-t7ghng17 299 29 American American NNP cord-269652-t7ghng17 299 30 Society Society NNP cord-269652-t7ghng17 299 31 for for IN cord-269652-t7ghng17 299 32 Microbiology Microbiology NNP cord-269652-t7ghng17 300 1 ( ( -LRB- cord-269652-t7ghng17 300 2 ASM)(a asm)(a JJ cord-269652-t7ghng17 300 3 ) ) -RRB- cord-269652-t7ghng17 300 4 Laboratory laboratory NN cord-269652-t7ghng17 300 5 medicine medicine NN cord-269652-t7ghng17 300 6 in in IN cord-269652-t7ghng17 300 7 neonatal neonatal JJ cord-269652-t7ghng17 300 8 sepsis sepsis NN cord-269652-t7ghng17 300 9 and and CC cord-269652-t7ghng17 300 10 inflammation inflammation NN cord-269652-t7ghng17 300 11 Group Group NNP cord-269652-t7ghng17 300 12 B B NNP cord-269652-t7ghng17 300 13 Streptococcus Streptococcus NNP cord-269652-t7ghng17 300 14 ST-17 ST-17 NNP cord-269652-t7ghng17 300 15 and and CC cord-269652-t7ghng17 300 16 emerging emerge VBG cord-269652-t7ghng17 300 17 ST-1 ST-1 NNP cord-269652-t7ghng17 300 18 clones clone NNS cord-269652-t7ghng17 300 19 by by IN cord-269652-t7ghng17 300 20 MALDI MALDI NNP cord-269652-t7ghng17 300 21 - - HYPH cord-269652-t7ghng17 300 22 TOF TOF NNP cord-269652-t7ghng17 300 23 mass mass NN cord-269652-t7ghng17 300 24 spectrometry spectrometry NN cord-269652-t7ghng17 300 25 Capnocytophaga Capnocytophaga NNP cord-269652-t7ghng17 300 26 species specie NNS cord-269652-t7ghng17 300 27 and and CC cord-269652-t7ghng17 300 28 perinatal perinatal JJ cord-269652-t7ghng17 300 29 infections infection NNS cord-269652-t7ghng17 300 30 : : : cord-269652-t7ghng17 301 1 case case NNP cord-269652-t7ghng17 301 2 report report NN cord-269652-t7ghng17 301 3 and and CC cord-269652-t7ghng17 301 4 review review NN cord-269652-t7ghng17 301 5 of of IN cord-269652-t7ghng17 301 6 the the DT cord-269652-t7ghng17 301 7 literature literature NN cord-269652-t7ghng17 301 8 Bloodstream bloodstream NN cord-269652-t7ghng17 301 9 infections infection NNS cord-269652-t7ghng17 301 10 by by IN cord-269652-t7ghng17 301 11 Malassezia Malassezia NNP cord-269652-t7ghng17 301 12 and and CC cord-269652-t7ghng17 301 13 Candida Candida NNP cord-269652-t7ghng17 301 14 species specie NNS cord-269652-t7ghng17 301 15 in in IN cord-269652-t7ghng17 301 16 critical critical JJ cord-269652-t7ghng17 301 17 care care NN cord-269652-t7ghng17 301 18 patients patient NNS cord-269652-t7ghng17 302 1 First first JJ cord-269652-t7ghng17 302 2 outbreak outbreak NN cord-269652-t7ghng17 302 3 of of IN cord-269652-t7ghng17 302 4 PVL PVL NNP cord-269652-t7ghng17 302 5 - - HYPH cord-269652-t7ghng17 302 6 positive positive JJ cord-269652-t7ghng17 302 7 nonmultiresistant nonmultiresistant JJ cord-269652-t7ghng17 302 8 MRSA MRSA NNP cord-269652-t7ghng17 302 9 in in IN cord-269652-t7ghng17 302 10 a a DT cord-269652-t7ghng17 302 11 neonatal neonatal JJ cord-269652-t7ghng17 302 12 ICU ICU NNP cord-269652-t7ghng17 302 13 in in IN cord-269652-t7ghng17 302 14 Australia Australia NNP cord-269652-t7ghng17 302 15 : : : cord-269652-t7ghng17 302 16 comparison comparison NN cord-269652-t7ghng17 302 17 of of IN cord-269652-t7ghng17 302 18 MALDI MALDI NNP cord-269652-t7ghng17 302 19 - - HYPH cord-269652-t7ghng17 302 20 TOF TOF NNP cord-269652-t7ghng17 302 21 and and CC cord-269652-t7ghng17 302 22 SNP SNP NNP cord-269652-t7ghng17 302 23 - - HYPH cord-269652-t7ghng17 302 24 plus plus CC cord-269652-t7ghng17 302 25 - - HYPH cord-269652-t7ghng17 302 26 binary binary JJ cord-269652-t7ghng17 302 27 gene gene NN cord-269652-t7ghng17 302 28 typing type VBG cord-269652-t7ghng17 302 29 MALDI MALDI NNP cord-269652-t7ghng17 302 30 - - HYPH cord-269652-t7ghng17 302 31 TOF TOF NNP cord-269652-t7ghng17 302 32 mass mass NN cord-269652-t7ghng17 302 33 spectrometry spectrometry NN cord-269652-t7ghng17 302 34 and and CC cord-269652-t7ghng17 302 35 microsatellite microsatellite JJ cord-269652-t7ghng17 302 36 markers marker NNS cord-269652-t7ghng17 302 37 to to TO cord-269652-t7ghng17 302 38 evaluate evaluate VB cord-269652-t7ghng17 302 39 Candida Candida NNP cord-269652-t7ghng17 302 40 parapsilosis parapsilosis NN cord-269652-t7ghng17 302 41 transmission transmission NN cord-269652-t7ghng17 302 42 in in IN cord-269652-t7ghng17 302 43 neonatal neonatal JJ cord-269652-t7ghng17 302 44 intensive intensive JJ cord-269652-t7ghng17 302 45 care care NN cord-269652-t7ghng17 302 46 units unit NNS cord-269652-t7ghng17 302 47 Nelson Nelson NNP cord-269652-t7ghng17 302 48 's 's POS cord-269652-t7ghng17 302 49 pediatric pediatric JJ cord-269652-t7ghng17 302 50 antimicrobial antimicrobial JJ cord-269652-t7ghng17 302 51 therapy therapy NN cord-269652-t7ghng17 302 52 Introduction introduction NN cord-269652-t7ghng17 302 53 to to IN cord-269652-t7ghng17 302 54 paediatric paediatric JJ cord-269652-t7ghng17 302 55 and and CC cord-269652-t7ghng17 302 56 perinatal perinatal JJ cord-269652-t7ghng17 302 57 drug drug NN cord-269652-t7ghng17 302 58 therapy therapy NN cord-269652-t7ghng17 303 1 The the DT cord-269652-t7ghng17 303 2 therapeutic therapeutic JJ cord-269652-t7ghng17 303 3 monitoring monitoring NN cord-269652-t7ghng17 303 4 of of IN cord-269652-t7ghng17 303 5 antimicrobial antimicrobial JJ cord-269652-t7ghng17 303 6 agents agent NNS cord-269652-t7ghng17 304 1 In in IN cord-269652-t7ghng17 304 2 vitro vitro FW cord-269652-t7ghng17 304 3 postantibiotic postantibiotic JJ cord-269652-t7ghng17 304 4 effect effect NN cord-269652-t7ghng17 304 5 and and CC cord-269652-t7ghng17 304 6 postantibiotic postantibiotic JJ cord-269652-t7ghng17 304 7 leukocyte leukocyte NN cord-269652-t7ghng17 304 8 enhancement enhancement NN cord-269652-t7ghng17 304 9 of of IN cord-269652-t7ghng17 304 10 tobramycin tobramycin NNS cord-269652-t7ghng17 304 11 Once once IN cord-269652-t7ghng17 304 12 - - HYPH cord-269652-t7ghng17 304 13 daily daily RB cord-269652-t7ghng17 304 14 versus versus IN cord-269652-t7ghng17 304 15 multiple multiple JJ cord-269652-t7ghng17 304 16 - - HYPH cord-269652-t7ghng17 304 17 daily daily JJ cord-269652-t7ghng17 304 18 dosing dosing NN cord-269652-t7ghng17 304 19 of of IN cord-269652-t7ghng17 304 20 aminoglycosides aminoglycoside NNS cord-269652-t7ghng17 305 1 Pharmacodynamic pharmacodynamic JJ cord-269652-t7ghng17 305 2 factors factor NNS cord-269652-t7ghng17 305 3 of of IN cord-269652-t7ghng17 305 4 antibiotic antibiotic JJ cord-269652-t7ghng17 305 5 efficacy efficacy NN cord-269652-t7ghng17 305 6 Gentamicin Gentamicin NNP cord-269652-t7ghng17 305 7 vs vs IN cord-269652-t7ghng17 305 8 cefotaxime cefotaxime NN cord-269652-t7ghng17 305 9 for for IN cord-269652-t7ghng17 305 10 therapy therapy NN cord-269652-t7ghng17 305 11 of of IN cord-269652-t7ghng17 305 12 neonatal neonatal JJ cord-269652-t7ghng17 305 13 sepsis sepsis NN cord-269652-t7ghng17 305 14 . . . cord-269652-t7ghng17 306 1 Relationship relationship NN cord-269652-t7ghng17 306 2 to to IN cord-269652-t7ghng17 306 3 drug drug NN cord-269652-t7ghng17 306 4 resistance resistance NN cord-269652-t7ghng17 307 1 Intravenous intravenous JJ cord-269652-t7ghng17 307 2 ceftriaxone ceftriaxone NN cord-269652-t7ghng17 307 3 and and CC cord-269652-t7ghng17 307 4 calcium calcium NN cord-269652-t7ghng17 307 5 in in IN cord-269652-t7ghng17 307 6 the the DT cord-269652-t7ghng17 307 7 neonate neonate NN cord-269652-t7ghng17 307 8 : : : cord-269652-t7ghng17 308 1 assessing assess VBG cord-269652-t7ghng17 308 2 the the DT cord-269652-t7ghng17 308 3 risk risk NN cord-269652-t7ghng17 308 4 for for IN cord-269652-t7ghng17 308 5 cardiopulmonary cardiopulmonary JJ cord-269652-t7ghng17 308 6 adverse adverse JJ cord-269652-t7ghng17 308 7 events event NNS cord-269652-t7ghng17 308 8 Oral oral JJ cord-269652-t7ghng17 308 9 acyclovir acyclovir JJ cord-269652-t7ghng17 308 10 suppression suppression NN cord-269652-t7ghng17 308 11 and and CC cord-269652-t7ghng17 308 12 neurodevelopment neurodevelopment JJ cord-269652-t7ghng17 308 13 after after IN cord-269652-t7ghng17 308 14 neonatal neonatal JJ cord-269652-t7ghng17 308 15 herpes herpes NNP cord-269652-t7ghng17 308 16 Committee Committee NNP cord-269652-t7ghng17 308 17 on on IN cord-269652-t7ghng17 308 18 Infectious Infectious NNP cord-269652-t7ghng17 308 19 Diseases Diseases NNPS cord-269652-t7ghng17 308 20 , , , cord-269652-t7ghng17 308 21 et et NNP cord-269652-t7ghng17 308 22 al al NNP cord-269652-t7ghng17 308 23 . . . cord-269652-t7ghng17 309 1 Guidance guidance NN cord-269652-t7ghng17 309 2 on on IN cord-269652-t7ghng17 309 3 management management NN cord-269652-t7ghng17 309 4 of of IN cord-269652-t7ghng17 309 5 asymptomatic asymptomatic JJ cord-269652-t7ghng17 309 6 neonates neonate NNS cord-269652-t7ghng17 309 7 born bear VBN cord-269652-t7ghng17 309 8 to to IN cord-269652-t7ghng17 309 9 women woman NNS cord-269652-t7ghng17 309 10 with with IN cord-269652-t7ghng17 309 11 active active JJ cord-269652-t7ghng17 309 12 genital genital JJ cord-269652-t7ghng17 309 13 herpes herpes NN cord-269652-t7ghng17 309 14 lesions lesion NNS cord-269652-t7ghng17 309 15 Six six CD cord-269652-t7ghng17 309 16 months month NNS cord-269652-t7ghng17 309 17 versus versus IN cord-269652-t7ghng17 309 18 six six CD cord-269652-t7ghng17 309 19 weeks week NNS cord-269652-t7ghng17 309 20 of of IN cord-269652-t7ghng17 309 21 oral oral JJ cord-269652-t7ghng17 309 22 valganciclovir valganciclovir NNS cord-269652-t7ghng17 309 23 for for IN cord-269652-t7ghng17 309 24 infants infant NNS cord-269652-t7ghng17 309 25 with with IN cord-269652-t7ghng17 309 26 symptomatic symptomatic JJ cord-269652-t7ghng17 309 27 congenital congenital JJ cord-269652-t7ghng17 309 28 cytomegalovirus cytomegalovirus NN cord-269652-t7ghng17 309 29 ( ( -LRB- cord-269652-t7ghng17 309 30 CMV CMV NNP cord-269652-t7ghng17 309 31 ) ) -RRB- cord-269652-t7ghng17 309 32 disease disease NN cord-269652-t7ghng17 309 33 with with IN cord-269652-t7ghng17 309 34 and and CC cord-269652-t7ghng17 309 35 without without IN cord-269652-t7ghng17 309 36 central central JJ cord-269652-t7ghng17 309 37 nervous nervous JJ cord-269652-t7ghng17 309 38 system system NN cord-269652-t7ghng17 309 39 ( ( -LRB- cord-269652-t7ghng17 309 40 CNS CNS NNP cord-269652-t7ghng17 309 41 ) ) -RRB- cord-269652-t7ghng17 309 42 involvement involvement NN cord-269652-t7ghng17 309 43 : : : cord-269652-t7ghng17 310 1 Results result NNS cord-269652-t7ghng17 310 2 of of IN cord-269652-t7ghng17 310 3 a a DT cord-269652-t7ghng17 310 4 Phase Phase NNP cord-269652-t7ghng17 310 5 III III NNP cord-269652-t7ghng17 310 6 , , , cord-269652-t7ghng17 310 7 randomized randomized JJ cord-269652-t7ghng17 310 8 , , , cord-269652-t7ghng17 310 9 double double JJ cord-269652-t7ghng17 310 10 - - HYPH cord-269652-t7ghng17 310 11 blind blind JJ cord-269652-t7ghng17 310 12 , , , cord-269652-t7ghng17 310 13 placebo placebo NN cord-269652-t7ghng17 310 14 - - HYPH cord-269652-t7ghng17 310 15 controlled control VBN cord-269652-t7ghng17 310 16 , , , cord-269652-t7ghng17 310 17 multinational multinational JJ cord-269652-t7ghng17 310 18 study study NN cord-269652-t7ghng17 310 19 . . . cord-269652-t7ghng17 311 1 2013 2013 CD cord-269652-t7ghng17 312 1 ID ID NNP cord-269652-t7ghng17 312 2 Week Week NNP cord-269652-t7ghng17 312 3 . . . cord-269652-t7ghng17 313 1 Infectious Infectious NNP cord-269652-t7ghng17 313 2 Disease Disease NNP cord-269652-t7ghng17 313 3 Society Society NNP cord-269652-t7ghng17 313 4 of of IN cord-269652-t7ghng17 313 5 America America NNP cord-269652-t7ghng17 313 6 Committee Committee NNP cord-269652-t7ghng17 313 7 On on IN cord-269652-t7ghng17 313 8 Infectious Infectious NNP cord-269652-t7ghng17 313 9 Diseases Diseases NNPS cord-269652-t7ghng17 313 10 . . . cord-269652-t7ghng17 314 1 Recommendations recommendation NNS cord-269652-t7ghng17 314 2 for for IN cord-269652-t7ghng17 314 3 prevention prevention NN cord-269652-t7ghng17 314 4 and and CC cord-269652-t7ghng17 314 5 control control NN cord-269652-t7ghng17 314 6 of of IN cord-269652-t7ghng17 314 7 influenza influenza NN cord-269652-t7ghng17 314 8 in in IN cord-269652-t7ghng17 314 9 children child NNS cord-269652-t7ghng17 314 10 Concurrent concurrent JJ cord-269652-t7ghng17 314 11 bloodstream bloodstream NN cord-269652-t7ghng17 314 12 infections infection NNS cord-269652-t7ghng17 314 13 in in IN cord-269652-t7ghng17 314 14 infants infant NNS cord-269652-t7ghng17 314 15 with with IN cord-269652-t7ghng17 314 16 necrotizing necrotize VBG cord-269652-t7ghng17 314 17 enterocolitis enterocolitis NN cord-269652-t7ghng17 314 18 Surgical surgical JJ cord-269652-t7ghng17 314 19 site site NN cord-269652-t7ghng17 314 20 infections infection NNS cord-269652-t7ghng17 314 21 in in IN cord-269652-t7ghng17 314 22 infants infant NNS cord-269652-t7ghng17 314 23 admitted admit VBN cord-269652-t7ghng17 314 24 to to IN cord-269652-t7ghng17 314 25 the the DT cord-269652-t7ghng17 314 26 neonatal neonatal JJ cord-269652-t7ghng17 314 27 intensive intensive JJ cord-269652-t7ghng17 314 28 care care NN cord-269652-t7ghng17 314 29 unit unit NN cord-269652-t7ghng17 314 30 Prevention Prevention NNP cord-269652-t7ghng17 314 31 of of IN cord-269652-t7ghng17 314 32 perinatal perinatal JJ cord-269652-t7ghng17 314 33 group group NN cord-269652-t7ghng17 314 34 B B NNP cord-269652-t7ghng17 314 35 streptococcal streptococcal JJ cord-269652-t7ghng17 314 36 disease disease NN cord-269652-t7ghng17 314 37 - - HYPH cord-269652-t7ghng17 314 38 revised revise VBN cord-269652-t7ghng17 314 39 guidelines guideline NNS cord-269652-t7ghng17 314 40 from from IN cord-269652-t7ghng17 314 41 CDC CDC NNP cord-269652-t7ghng17 314 42 Group Group NNP cord-269652-t7ghng17 314 43 B B NNP cord-269652-t7ghng17 314 44 Strep Strep NNP cord-269652-t7ghng17 314 45 ( ( -LRB- cord-269652-t7ghng17 314 46 GBS GBS NNP cord-269652-t7ghng17 314 47 ) ) -RRB- cord-269652-t7ghng17 314 48 Strategies Strategies NNP cord-269652-t7ghng17 314 49 for for IN cord-269652-t7ghng17 314 50 prevention prevention NN cord-269652-t7ghng17 314 51 of of IN cord-269652-t7ghng17 314 52 health health NN cord-269652-t7ghng17 314 53 careassociated careassociate VBD cord-269652-t7ghng17 314 54 infections infection NNS cord-269652-t7ghng17 314 55 in in IN cord-269652-t7ghng17 314 56 the the DT cord-269652-t7ghng17 314 57 NICU NICU NNP cord-269652-t7ghng17 314 58 Healthcare Healthcare NNP cord-269652-t7ghng17 314 59 Infection Infection NNP cord-269652-t7ghng17 314 60 Control Control NNP cord-269652-t7ghng17 314 61 Practices Practices NNPS cord-269652-t7ghng17 314 62 Advisory Advisory NNP cord-269652-t7ghng17 314 63 Committee Committee NNP cord-269652-t7ghng17 314 64 , , , cord-269652-t7ghng17 314 65 et et NNP cord-269652-t7ghng17 314 66 al al NNP cord-269652-t7ghng17 314 67 . . . cord-269652-t7ghng17 315 1 Guideline guideline NN cord-269652-t7ghng17 315 2 for for IN cord-269652-t7ghng17 315 3 hand hand NN cord-269652-t7ghng17 315 4 hygiene hygiene NN cord-269652-t7ghng17 315 5 in in IN cord-269652-t7ghng17 315 6 health health NN cord-269652-t7ghng17 315 7 - - HYPH cord-269652-t7ghng17 315 8 care care NN cord-269652-t7ghng17 315 9 settings setting NNS cord-269652-t7ghng17 315 10 : : : cord-269652-t7ghng17 315 11 recommendations recommendation NNS cord-269652-t7ghng17 315 12 of of IN cord-269652-t7ghng17 315 13 the the DT cord-269652-t7ghng17 315 14 Healthcare Healthcare NNP cord-269652-t7ghng17 315 15 Infection Infection NNP cord-269652-t7ghng17 315 16 Control Control NNP cord-269652-t7ghng17 315 17 Practices Practices NNPS cord-269652-t7ghng17 315 18 Advisory Advisory NNP cord-269652-t7ghng17 315 19 Committee Committee NNP cord-269652-t7ghng17 315 20 and and CC cord-269652-t7ghng17 315 21 the the DT cord-269652-t7ghng17 315 22 HIC HIC NNP cord-269652-t7ghng17 315 23 - - HYPH cord-269652-t7ghng17 315 24 PAC PAC NNP cord-269652-t7ghng17 315 25 / / SYM cord-269652-t7ghng17 315 26 SHEA SHEA NNP cord-269652-t7ghng17 315 27 / / SYM cord-269652-t7ghng17 315 28 APIC APIC NNP cord-269652-t7ghng17 315 29 / / SYM cord-269652-t7ghng17 315 30 IDSA IDSA NNP cord-269652-t7ghng17 315 31 Hand Hand NNP cord-269652-t7ghng17 315 32 Hygiene Hygiene NNP cord-269652-t7ghng17 315 33 Task Task NNP cord-269652-t7ghng17 315 34 Force Force NNP cord-269652-t7ghng17 315 35 Hygiene Hygiene NNP cord-269652-t7ghng17 315 36 in in IN cord-269652-t7ghng17 315 37 Healthcare Healthcare NNP cord-269652-t7ghng17 315 38 Settings Settings NNPS cord-269652-t7ghng17 315 39 How how WRB cord-269652-t7ghng17 315 40 to to TO cord-269652-t7ghng17 315 41 communicate communicate VB cord-269652-t7ghng17 315 42 with with IN cord-269652-t7ghng17 315 43 vaccine vaccine NN cord-269652-t7ghng17 315 44 - - HYPH cord-269652-t7ghng17 315 45 hesitant hesitant JJ cord-269652-t7ghng17 315 46 parents parent NNS cord-269652-t7ghng17 316 1 Recommended recommend VBN cord-269652-t7ghng17 316 2 childhood childhood NN cord-269652-t7ghng17 316 3 and and CC cord-269652-t7ghng17 316 4 adolescent adolescent JJ cord-269652-t7ghng17 316 5 immunization immunization NN cord-269652-t7ghng17 316 6 schedule schedule NN cord-269652-t7ghng17 316 7 - - : cord-269652-t7ghng17 316 8 United United NNP cord-269652-t7ghng17 316 9 States States NNP cord-269652-t7ghng17 316 10 Committee Committee NNP cord-269652-t7ghng17 316 11 On on IN cord-269652-t7ghng17 316 12 Practice Practice NNP cord-269652-t7ghng17 316 13 And and CC cord-269652-t7ghng17 316 14 Ambulatory Ambulatory NNP cord-269652-t7ghng17 316 15 Medicine Medicine NNP cord-269652-t7ghng17 316 16 , , , cord-269652-t7ghng17 316 17 et et NNP cord-269652-t7ghng17 316 18 al al NNP cord-269652-t7ghng17 316 19 . . . cord-269652-t7ghng17 317 1 Immunizing immunize VBG cord-269652-t7ghng17 317 2 parents parent NNS cord-269652-t7ghng17 317 3 and and CC cord-269652-t7ghng17 317 4 other other JJ cord-269652-t7ghng17 317 5 close close JJ cord-269652-t7ghng17 317 6 family family NN cord-269652-t7ghng17 317 7 contacts contact NNS cord-269652-t7ghng17 317 8 in in IN cord-269652-t7ghng17 317 9 the the DT cord-269652-t7ghng17 317 10 pediatric pediatric JJ cord-269652-t7ghng17 317 11 office office NN cord-269652-t7ghng17 317 12 setting set VBG cord-269652-t7ghng17 317 13 Updated update VBN cord-269652-t7ghng17 317 14 recommendations recommendation NNS cord-269652-t7ghng17 317 15 for for IN cord-269652-t7ghng17 317 16 use use NN cord-269652-t7ghng17 317 17 of of IN cord-269652-t7ghng17 317 18 tetanus tetanus NN cord-269652-t7ghng17 317 19 toxoid toxoid NN cord-269652-t7ghng17 317 20 , , , cord-269652-t7ghng17 317 21 reduced reduce VBN cord-269652-t7ghng17 317 22 diphtheria diphtheria NN cord-269652-t7ghng17 317 23 toxoid toxoid NN cord-269652-t7ghng17 317 24 , , , cord-269652-t7ghng17 317 25 and and CC cord-269652-t7ghng17 317 26 acellular acellular JJ cord-269652-t7ghng17 317 27 pertussis pertussis NN cord-269652-t7ghng17 317 28 vaccine vaccine NN cord-269652-t7ghng17 317 29 ( ( -LRB- cord-269652-t7ghng17 317 30 Tdap Tdap NNP cord-269652-t7ghng17 317 31 ) ) -RRB- cord-269652-t7ghng17 317 32 in in IN cord-269652-t7ghng17 317 33 pregnant pregnant JJ cord-269652-t7ghng17 317 34 women woman NNS cord-269652-t7ghng17 317 35 - - : cord-269652-t7ghng17 317 36 Advisory Advisory NNP cord-269652-t7ghng17 317 37 Committee Committee NNP cord-269652-t7ghng17 317 38 on on IN cord-269652-t7ghng17 317 39 Immunization Immunization NNP cord-269652-t7ghng17 317 40 Practices Practices NNPS cord-269652-t7ghng17 317 41 ( ( -LRB- cord-269652-t7ghng17 317 42 ACIP ACIP NNP cord-269652-t7ghng17 317 43 ) ) -RRB- cord-269652-t7ghng17 317 44 Importance importance NN cord-269652-t7ghng17 317 45 of of IN cord-269652-t7ghng17 317 46 timing timing NN cord-269652-t7ghng17 317 47 of of IN cord-269652-t7ghng17 317 48 maternal maternal JJ cord-269652-t7ghng17 317 49 combined combine VBN cord-269652-t7ghng17 317 50 tetanus tetanus NN cord-269652-t7ghng17 317 51 , , , cord-269652-t7ghng17 317 52 diphtheria diphtheria NN cord-269652-t7ghng17 317 53 , , , cord-269652-t7ghng17 317 54 and and CC cord-269652-t7ghng17 317 55 acellular acellular JJ cord-269652-t7ghng17 317 56 pertussis pertussis NN cord-269652-t7ghng17 317 57 ( ( -LRB- cord-269652-t7ghng17 317 58 Tdap Tdap NNP cord-269652-t7ghng17 317 59 ) ) -RRB- cord-269652-t7ghng17 317 60 immunization immunization NN cord-269652-t7ghng17 317 61 and and CC cord-269652-t7ghng17 317 62 protection protection NN cord-269652-t7ghng17 317 63 of of IN cord-269652-t7ghng17 317 64 young young JJ cord-269652-t7ghng17 317 65 infants infant NNS cord-269652-t7ghng17 318 1 Updated update VBN cord-269652-t7ghng17 318 2 guidance guidance NN cord-269652-t7ghng17 318 3 for for IN cord-269652-t7ghng17 318 4 palivizumab palivizumab JJ cord-269652-t7ghng17 318 5 prophylaxis prophylaxis NN cord-269652-t7ghng17 318 6 among among IN cord-269652-t7ghng17 318 7 infants infant NNS cord-269652-t7ghng17 318 8 and and CC cord-269652-t7ghng17 318 9 young young JJ cord-269652-t7ghng17 318 10 children child NNS cord-269652-t7ghng17 318 11 at at IN cord-269652-t7ghng17 318 12 increased increase VBN cord-269652-t7ghng17 318 13 risk risk NN cord-269652-t7ghng17 318 14 of of IN cord-269652-t7ghng17 318 15 hospitalization hospitalization NN cord-269652-t7ghng17 318 16 for for IN cord-269652-t7ghng17 318 17 respiratory respiratory JJ cord-269652-t7ghng17 318 18 syncytial syncytial JJ cord-269652-t7ghng17 318 19 virus virus NN cord-269652-t7ghng17 318 20 infection infection NN cord-269652-t7ghng17 318 21 Neonatal neonatal JJ cord-269652-t7ghng17 318 22 sepsis sepsis NN cord-269652-t7ghng17 318 23 : : : cord-269652-t7ghng17 318 24 the the DT cord-269652-t7ghng17 318 25 gut gut NN cord-269652-t7ghng17 318 26 connection connection NN cord-269652-t7ghng17 318 27 Infectious Infectious NNP cord-269652-t7ghng17 318 28 Diseases Diseases NNPS cord-269652-t7ghng17 318 29 Society Society NNP cord-269652-t7ghng17 318 30 of of IN cord-269652-t7ghng17 318 31 America America NNP cord-269652-t7ghng17 318 32 and and CC cord-269652-t7ghng17 318 33 the the DT cord-269652-t7ghng17 318 34 Society Society NNP cord-269652-t7ghng17 318 35 for for IN cord-269652-t7ghng17 318 36 Healthcare Healthcare NNP cord-269652-t7ghng17 318 37 Epidemiology Epidemiology NNP cord-269652-t7ghng17 318 38 of of IN cord-269652-t7ghng17 318 39 America America NNP cord-269652-t7ghng17 318 40 guidelines guideline NNS cord-269652-t7ghng17 318 41 for for IN cord-269652-t7ghng17 318 42 developing develop VBG cord-269652-t7ghng17 318 43 an an DT cord-269652-t7ghng17 318 44 institutional institutional JJ cord-269652-t7ghng17 318 45 program program NN cord-269652-t7ghng17 318 46 to to TO cord-269652-t7ghng17 318 47 enhance enhance VB cord-269652-t7ghng17 318 48 antimicrobial antimicrobial JJ cord-269652-t7ghng17 318 49 stewardship stewardship NN cord-269652-t7ghng17 318 50 Probiotics probiotic NNS cord-269652-t7ghng17 318 51 and and CC cord-269652-t7ghng17 318 52 prebiotics prebiotic NNS cord-269652-t7ghng17 318 53 in in IN cord-269652-t7ghng17 318 54 pediatrics pediatric NNS cord-269652-t7ghng17 318 55 Probiotics Probiotics NNP cord-269652-t7ghng17 318 56 for for IN cord-269652-t7ghng17 318 57 prevention prevention NN cord-269652-t7ghng17 318 58 of of IN cord-269652-t7ghng17 318 59 necrotizing necrotize VBG cord-269652-t7ghng17 318 60 enterocolitis enterocolitis NN cord-269652-t7ghng17 318 61 in in IN cord-269652-t7ghng17 318 62 preterm preterm JJR cord-269652-t7ghng17 318 63 infants infant NNS cord-269652-t7ghng17 318 64 Probiotics probiotic NNS cord-269652-t7ghng17 318 65 for for IN cord-269652-t7ghng17 318 66 prevention prevention NN cord-269652-t7ghng17 318 67 of of IN cord-269652-t7ghng17 318 68 necrotizing necrotize VBG cord-269652-t7ghng17 318 69 enterocolitis enterocolitis NN cord-269652-t7ghng17 318 70 in in IN cord-269652-t7ghng17 318 71 preterm preterm JJR cord-269652-t7ghng17 318 72 infants infant NNS cord-269652-t7ghng17 318 73 Transmission transmission NN cord-269652-t7ghng17 318 74 - - HYPH cord-269652-t7ghng17 318 75 based base VBN cord-269652-t7ghng17 318 76 precautions precaution NNS