id sid tid token lemma pos cord-333600-k6ws97at 1 1 key key NN cord-333600-k6ws97at 1 2 : : : cord-333600-k6ws97at 2 1 cord-333600-k6ws97at cord-333600-k6ws97at NNP cord-333600-k6ws97at 2 2 authors author NNS cord-333600-k6ws97at 2 3 : : : cord-333600-k6ws97at 2 4 Mihm Mihm NNP cord-333600-k6ws97at 2 5 , , , cord-333600-k6ws97at 2 6 Sabine Sabine NNP cord-333600-k6ws97at 2 7 title title NN cord-333600-k6ws97at 2 8 : : : cord-333600-k6ws97at 2 9 COVID-19 covid-19 VB cord-333600-k6ws97at 2 10 : : : cord-333600-k6ws97at 2 11 Possible possible JJ cord-333600-k6ws97at 2 12 Impact impact NN cord-333600-k6ws97at 2 13 of of IN cord-333600-k6ws97at 2 14 the the DT cord-333600-k6ws97at 2 15 Genetic Genetic NNP cord-333600-k6ws97at 2 16 Background Background NNP cord-333600-k6ws97at 2 17 in in IN cord-333600-k6ws97at 2 18 IFNL IFNL NNP cord-333600-k6ws97at 2 19 Genes Genes NNP cord-333600-k6ws97at 2 20 on on IN cord-333600-k6ws97at 2 21 Disease Disease NNP cord-333600-k6ws97at 2 22 Outcomes Outcomes NNP cord-333600-k6ws97at 2 23 date date NN cord-333600-k6ws97at 2 24 : : : cord-333600-k6ws97at 2 25 2020 2020 CD cord-333600-k6ws97at 2 26 - - HYPH cord-333600-k6ws97at 2 27 04 04 CD cord-333600-k6ws97at 2 28 - - HYPH cord-333600-k6ws97at 2 29 28 28 CD cord-333600-k6ws97at 2 30 journal journal NN cord-333600-k6ws97at 2 31 : : : cord-333600-k6ws97at 2 32 J J NNP cord-333600-k6ws97at 2 33 Innate Innate NNP cord-333600-k6ws97at 2 34 Immun Immun NNP cord-333600-k6ws97at 2 35 DOI DOI NNP cord-333600-k6ws97at 2 36 : : : cord-333600-k6ws97at 2 37 10.1159/000508076 10.1159/000508076 CD cord-333600-k6ws97at 2 38 sha sha NNP cord-333600-k6ws97at 2 39 : : : cord-333600-k6ws97at 3 1 326fff8a3bcfea7f87c81608c3867ccf4e9eb1d4 326fff8a3bcfea7f87c81608c3867ccf4e9eb1d4 LS cord-333600-k6ws97at 3 2 doc_id doc_id CD cord-333600-k6ws97at 3 3 : : : cord-333600-k6ws97at 3 4 333600 333600 CD cord-333600-k6ws97at 3 5 cord_uid cord_uid NNS cord-333600-k6ws97at 3 6 : : : cord-333600-k6ws97at 4 1 k6ws97at k6ws97at NNP cord-333600-k6ws97at 4 2 nan nan NNP cord-333600-k6ws97at 5 1 The the DT cord-333600-k6ws97at 5 2 causative causative JJ cord-333600-k6ws97at 5 3 agent agent NN cord-333600-k6ws97at 5 4 of of IN cord-333600-k6ws97at 5 5 the the DT cord-333600-k6ws97at 5 6 pandemic pandemic NN cord-333600-k6ws97at 5 7 COVID-19 covid-19 CD cord-333600-k6ws97at 5 8 outbreak outbreak NN cord-333600-k6ws97at 5 9 , , , cord-333600-k6ws97at 5 10 SARS SARS NNP cord-333600-k6ws97at 5 11 - - HYPH cord-333600-k6ws97at 5 12 CoV-2 CoV-2 NNP cord-333600-k6ws97at 5 13 , , , cord-333600-k6ws97at 5 14 is be VBZ cord-333600-k6ws97at 5 15 a a DT cord-333600-k6ws97at 5 16 member member NN cord-333600-k6ws97at 5 17 of of IN cord-333600-k6ws97at 5 18 the the DT cord-333600-k6ws97at 5 19 Coronaviridae Coronaviridae NNP cord-333600-k6ws97at 5 20 family family NN cord-333600-k6ws97at 5 21 of of IN cord-333600-k6ws97at 5 22 enveloped envelop VBN cord-333600-k6ws97at 5 23 viruses virus NNS cord-333600-k6ws97at 5 24 with with IN cord-333600-k6ws97at 5 25 a a DT cord-333600-k6ws97at 5 26 positive positive JJ cord-333600-k6ws97at 5 27 - - HYPH cord-333600-k6ws97at 5 28 sense sense NN cord-333600-k6ws97at 5 29 singlestranded singlestranded NNP cord-333600-k6ws97at 5 30 ( ( -LRB- cord-333600-k6ws97at 5 31 ss ss NNP cord-333600-k6ws97at 5 32 ) ) -RRB- cord-333600-k6ws97at 5 33 RNA RNA NNP cord-333600-k6ws97at 5 34 genome genome NN cord-333600-k6ws97at 5 35 [ [ -LRB- cord-333600-k6ws97at 5 36 1 1 CD cord-333600-k6ws97at 5 37 ] ] -RRB- cord-333600-k6ws97at 5 38 . . . cord-333600-k6ws97at 6 1 Generally generally RB cord-333600-k6ws97at 6 2 , , , cord-333600-k6ws97at 6 3 ssRNA ssrna NN cord-333600-k6ws97at 6 4 viruses virus NNS cord-333600-k6ws97at 6 5 are be VBP cord-333600-k6ws97at 6 6 recognized recognize VBN cord-333600-k6ws97at 6 7 by by IN cord-333600-k6ws97at 6 8 the the DT cord-333600-k6ws97at 6 9 host host NN cord-333600-k6ws97at 6 10 immune immune JJ cord-333600-k6ws97at 6 11 system system NN cord-333600-k6ws97at 6 12 in in IN cord-333600-k6ws97at 6 13 first first JJ cord-333600-k6ws97at 6 14 - - HYPH cord-333600-k6ws97at 6 15 line line NN cord-333600-k6ws97at 6 16 defense defense NN cord-333600-k6ws97at 6 17 via via IN cord-333600-k6ws97at 6 18 innate innate JJ cord-333600-k6ws97at 6 19 pattern pattern NN cord-333600-k6ws97at 6 20 recognition recognition NN cord-333600-k6ws97at 6 21 receptors receptor NNS cord-333600-k6ws97at 6 22 ( ( -LRB- cord-333600-k6ws97at 6 23 PRR PRR NNP cord-333600-k6ws97at 6 24 ) ) -RRB- cord-333600-k6ws97at 6 25 , , , cord-333600-k6ws97at 6 26 such such JJ cord-333600-k6ws97at 6 27 as as IN cord-333600-k6ws97at 6 28 Toll Toll NNP cord-333600-k6ws97at 6 29 - - HYPH cord-333600-k6ws97at 6 30 like like JJ cord-333600-k6ws97at 6 31 receptor receptor NN cord-333600-k6ws97at 6 32 7 7 CD cord-333600-k6ws97at 6 33 ( ( -LRB- cord-333600-k6ws97at 6 34 TLR7 TLR7 NNP cord-333600-k6ws97at 6 35 ) ) -RRB- cord-333600-k6ws97at 6 36 , , , cord-333600-k6ws97at 6 37 which which WDT cord-333600-k6ws97at 6 38 is be VBZ cord-333600-k6ws97at 6 39 a a DT cord-333600-k6ws97at 6 40 primary primary JJ cord-333600-k6ws97at 6 41 sensor sensor NN cord-333600-k6ws97at 6 42 for for IN cord-333600-k6ws97at 6 43 extracellular extracellular JJ cord-333600-k6ws97at 6 44 or or CC cord-333600-k6ws97at 6 45 endosomal endosomal NN cord-333600-k6ws97at 6 46 nucleic nucleic JJ cord-333600-k6ws97at 6 47 acid acid NN cord-333600-k6ws97at 6 48 patterns pattern NNS cord-333600-k6ws97at 6 49 of of IN cord-333600-k6ws97at 6 50 viral viral JJ cord-333600-k6ws97at 6 51 origin origin NN cord-333600-k6ws97at 6 52 . . . cord-333600-k6ws97at 7 1 Mouse Mouse NNP cord-333600-k6ws97at 7 2 hepatitis hepatitis NNP cord-333600-k6ws97at 7 3 corona corona NN cord-333600-k6ws97at 7 4 virus virus NN cord-333600-k6ws97at 7 5 ( ( -LRB- cord-333600-k6ws97at 7 6 MHV MHV NNP cord-333600-k6ws97at 7 7 ) ) -RRB- cord-333600-k6ws97at 7 8 is be VBZ cord-333600-k6ws97at 7 9 a a DT cord-333600-k6ws97at 7 10 prototypic prototypic NNP cord-333600-k6ws97at 7 11 β β NN cord-333600-k6ws97at 7 12 - - HYPH cord-333600-k6ws97at 7 13 genus genus JJ cord-333600-k6ws97at 7 14 coronavirus coronavirus NN cord-333600-k6ws97at 7 15 and and CC cord-333600-k6ws97at 7 16 a a DT cord-333600-k6ws97at 7 17 well well RB cord-333600-k6ws97at 7 18 - - HYPH cord-333600-k6ws97at 7 19 studied study VBN cord-333600-k6ws97at 7 20 model model NN cord-333600-k6ws97at 7 21 for for IN cord-333600-k6ws97at 7 22 SARS SARS NNP cord-333600-k6ws97at 7 23 - - HYPH cord-333600-k6ws97at 7 24 CoV. CoV. NNP cord-333600-k6ws97at 7 25 Host Host NNP cord-333600-k6ws97at 7 26 control control NN cord-333600-k6ws97at 7 27 of of IN cord-333600-k6ws97at 7 28 MHV MHV NNP cord-333600-k6ws97at 7 29 infection infection NN cord-333600-k6ws97at 7 30 is be VBZ cord-333600-k6ws97at 7 31 completely completely RB cord-333600-k6ws97at 7 32 dependent dependent JJ cord-333600-k6ws97at 7 33 on on IN cord-333600-k6ws97at 7 34 TLR7 TLR7 NNP cord-333600-k6ws97at 7 35 triggering trigger VBG cord-333600-k6ws97at 7 36 by by IN cord-333600-k6ws97at 7 37 viral viral JJ cord-333600-k6ws97at 7 38 RNA RNA NNP cord-333600-k6ws97at 7 39 causing cause VBG cord-333600-k6ws97at 7 40 an an DT cord-333600-k6ws97at 7 41 immediate immediate JJ cord-333600-k6ws97at 7 42 interferon interferon NN cord-333600-k6ws97at 7 43 ( ( -LRB- cord-333600-k6ws97at 7 44 IFN IFN NNP cord-333600-k6ws97at 7 45 ) ) -RRB- cord-333600-k6ws97at 7 46 response response NN cord-333600-k6ws97at 7 47 [ [ -LRB- cord-333600-k6ws97at 7 48 2 2 CD cord-333600-k6ws97at 7 49 ] ] -RRB- cord-333600-k6ws97at 7 50 . . . cord-333600-k6ws97at 8 1 Similarly similarly RB cord-333600-k6ws97at 8 2 , , , cord-333600-k6ws97at 8 3 in in IN cord-333600-k6ws97at 8 4 MERS MERS NNP cord-333600-k6ws97at 8 5 - - HYPH cord-333600-k6ws97at 8 6 CoV CoV NNP cord-333600-k6ws97at 8 7 infection infection NN cord-333600-k6ws97at 8 8 , , , cord-333600-k6ws97at 8 9 a a DT cord-333600-k6ws97at 8 10 timely timely JJ cord-333600-k6ws97at 8 11 IFN IFN NNP cord-333600-k6ws97at 8 12 signaling signaling NN cord-333600-k6ws97at 8 13 has have VBZ cord-333600-k6ws97at 8 14 been be VBN cord-333600-k6ws97at 8 15 shown show VBN cord-333600-k6ws97at 8 16 to to TO cord-333600-k6ws97at 8 17 protect protect VB cord-333600-k6ws97at 8 18 mice mouse NNS cord-333600-k6ws97at 8 19 from from IN cord-333600-k6ws97at 8 20 a a DT cord-333600-k6ws97at 8 21 lethal lethal JJ cord-333600-k6ws97at 8 22 outcome outcome NN cord-333600-k6ws97at 8 23 , , , cord-333600-k6ws97at 8 24 i.e. i.e. FW cord-333600-k6ws97at 8 25 , , , cord-333600-k6ws97at 8 26 fatal fatal JJ cord-333600-k6ws97at 8 27 pneumonia pneumonia NN cord-333600-k6ws97at 8 28 [ [ -LRB- cord-333600-k6ws97at 8 29 3 3 CD cord-333600-k6ws97at 8 30 ] ] -RRB- cord-333600-k6ws97at 8 31 . . . cord-333600-k6ws97at 9 1 TLR7 TLR7 NNP cord-333600-k6ws97at 9 2 is be VBZ cord-333600-k6ws97at 9 3 a a DT cord-333600-k6ws97at 9 4 gonosomal gonosomal NN cord-333600-k6ws97at 9 5 - - HYPH cord-333600-k6ws97at 9 6 encoded encode VBN cord-333600-k6ws97at 9 7 , , , cord-333600-k6ws97at 9 8 X x NN cord-333600-k6ws97at 9 9 - - HYPH cord-333600-k6ws97at 9 10 linked link VBN cord-333600-k6ws97at 9 11 gene gene NN cord-333600-k6ws97at 9 12 . . . cord-333600-k6ws97at 10 1 Sex sex NN cord-333600-k6ws97at 10 2 differences difference NNS cord-333600-k6ws97at 10 3 in in IN cord-333600-k6ws97at 10 4 TLR7 TLR7 NNP cord-333600-k6ws97at 10 5 responses response NNS cord-333600-k6ws97at 10 6 have have VBP cord-333600-k6ws97at 10 7 been be VBN cord-333600-k6ws97at 10 8 reported report VBN cord-333600-k6ws97at 10 9 for for IN cord-333600-k6ws97at 10 10 humans human NNS cord-333600-k6ws97at 10 11 -with -with : cord-333600-k6ws97at 10 12 female female JJ cord-333600-k6ws97at 10 13 sex sex NN cord-333600-k6ws97at 10 14 better well RBR cord-333600-k6ws97at 10 15 coping cope VBG cord-333600-k6ws97at 10 16 with with IN cord-333600-k6ws97at 10 17 viral viral JJ cord-333600-k6ws97at 10 18 infection infection NN cord-333600-k6ws97at 10 19 [ [ -LRB- cord-333600-k6ws97at 10 20 4 4 CD cord-333600-k6ws97at 10 21 ] ] -RRB- cord-333600-k6ws97at 10 22 [ [ -LRB- cord-333600-k6ws97at 10 23 5 5 CD cord-333600-k6ws97at 10 24 ] ] -RRB- cord-333600-k6ws97at 10 25 [ [ -LRB- cord-333600-k6ws97at 10 26 6 6 CD cord-333600-k6ws97at 10 27 ] ] -RRB- cord-333600-k6ws97at 11 1 -which -which NNP cord-333600-k6ws97at 11 2 is be VBZ cord-333600-k6ws97at 11 3 also also RB cord-333600-k6ws97at 11 4 a a DT cord-333600-k6ws97at 11 5 feature feature NN cord-333600-k6ws97at 11 6 of of IN cord-333600-k6ws97at 11 7 COVID-19 covid-19 NN cord-333600-k6ws97at 11 8 . . . cord-333600-k6ws97at 12 1 Upon upon IN cord-333600-k6ws97at 12 2 binding bind VBG cord-333600-k6ws97at 12 3 viral viral JJ cord-333600-k6ws97at 12 4 nucleic nucleic JJ cord-333600-k6ws97at 12 5 acid acid NN cord-333600-k6ws97at 12 6 motifs motif NNS cord-333600-k6ws97at 12 7 , , , cord-333600-k6ws97at 12 8 TLR7 TLR7 NNP cord-333600-k6ws97at 12 9 induces induce VBZ cord-333600-k6ws97at 12 10 the the DT cord-333600-k6ws97at 12 11 expression expression NN cord-333600-k6ws97at 12 12 of of IN cord-333600-k6ws97at 12 13 type type NN cord-333600-k6ws97at 12 14 I -PRON- PRP cord-333600-k6ws97at 12 15 IFNs ifns VBP cord-333600-k6ws97at 12 16 ( ( -LRB- cord-333600-k6ws97at 12 17 IFN IFN NNP cord-333600-k6ws97at 12 18 - - HYPH cord-333600-k6ws97at 12 19 α α NNP cord-333600-k6ws97at 12 20 and and CC cord-333600-k6ws97at 12 21 IFN IFN NNP cord-333600-k6ws97at 12 22 - - HYPH cord-333600-k6ws97at 12 23 β β NNP cord-333600-k6ws97at 12 24 ) ) -RRB- cord-333600-k6ws97at 12 25 and and CC cord-333600-k6ws97at 12 26 the the DT cord-333600-k6ws97at 12 27 expression expression NN cord-333600-k6ws97at 12 28 of of IN cord-333600-k6ws97at 12 29 the the DT cord-333600-k6ws97at 12 30 more more RBR cord-333600-k6ws97at 12 31 recently recently RB cord-333600-k6ws97at 12 32 described describe VBN cord-333600-k6ws97at 12 33 family family NN cord-333600-k6ws97at 12 34 of of IN cord-333600-k6ws97at 12 35 type type NN cord-333600-k6ws97at 12 36 III iii CD cord-333600-k6ws97at 12 37 IFNs ifn NNS cord-333600-k6ws97at 12 38 ( ( -LRB- cord-333600-k6ws97at 12 39 IFN IFN NNP cord-333600-k6ws97at 12 40 - - HYPH cord-333600-k6ws97at 12 41 λ λ NNP cord-333600-k6ws97at 12 42 [ [ -LRB- cord-333600-k6ws97at 12 43 1 1 CD cord-333600-k6ws97at 12 44 ] ] -RRB- cord-333600-k6ws97at 12 45 [ [ -LRB- cord-333600-k6ws97at 12 46 2 2 CD cord-333600-k6ws97at 12 47 ] ] -RRB- cord-333600-k6ws97at 12 48 [ [ -LRB- cord-333600-k6ws97at 12 49 3 3 CD cord-333600-k6ws97at 12 50 ] ] -RRB- cord-333600-k6ws97at 12 51 [ [ -LRB- cord-333600-k6ws97at 12 52 4 4 CD cord-333600-k6ws97at 12 53 ] ] -RRB- cord-333600-k6ws97at 12 54 . . . cord-333600-k6ws97at 13 1 During during IN cord-333600-k6ws97at 13 2 viral viral JJ cord-333600-k6ws97at 13 3 infection infection NN cord-333600-k6ws97at 13 4 of of IN cord-333600-k6ws97at 13 5 lung lung NN cord-333600-k6ws97at 13 6 and and CC cord-333600-k6ws97at 13 7 liver liver NN cord-333600-k6ws97at 13 8 epithelium epithelium NN cord-333600-k6ws97at 13 9 , , , cord-333600-k6ws97at 13 10 for for IN cord-333600-k6ws97at 13 11 example example NN cord-333600-k6ws97at 13 12 , , , cord-333600-k6ws97at 13 13 notably notably RB cord-333600-k6ws97at 13 14 , , , cord-333600-k6ws97at 13 15 type type NN cord-333600-k6ws97at 13 16 III iii CD cord-333600-k6ws97at 13 17 IFNs ifn NNS cord-333600-k6ws97at 13 18 , , , cord-333600-k6ws97at 13 19 rather rather RB cord-333600-k6ws97at 13 20 than than IN cord-333600-k6ws97at 13 21 type type NN cord-333600-k6ws97at 13 22 I -PRON- PRP cord-333600-k6ws97at 13 23 IFNs ifn NNS cord-333600-k6ws97at 13 24 , , , cord-333600-k6ws97at 13 25 are be VBP cord-333600-k6ws97at 13 26 found find VBN cord-333600-k6ws97at 13 27 to to TO cord-333600-k6ws97at 13 28 be be VB cord-333600-k6ws97at 13 29 activated activate VBN cord-333600-k6ws97at 13 30 [ [ -LRB- cord-333600-k6ws97at 13 31 7 7 CD cord-333600-k6ws97at 13 32 ] ] -RRB- cord-333600-k6ws97at 13 33 . . . cord-333600-k6ws97at 14 1 Type type NN cord-333600-k6ws97at 14 2 III III NNP cord-333600-k6ws97at 14 3 IFNs ifn NNS cord-333600-k6ws97at 14 4 seem seem VBP cord-333600-k6ws97at 14 5 to to TO cord-333600-k6ws97at 14 6 be be VB cord-333600-k6ws97at 14 7 the the DT cord-333600-k6ws97at 14 8 major major JJ cord-333600-k6ws97at 14 9 IFNs ifn NNS cord-333600-k6ws97at 14 10 induced induce VBN cord-333600-k6ws97at 14 11 in in IN cord-333600-k6ws97at 14 12 airway airway JJ cord-333600-k6ws97at 14 13 epithelial epithelial JJ cord-333600-k6ws97at 14 14 cells cell NNS cord-333600-k6ws97at 14 15 during during IN cord-333600-k6ws97at 14 16 infection infection NN cord-333600-k6ws97at 14 17 [ [ -LRB- cord-333600-k6ws97at 14 18 7 7 CD cord-333600-k6ws97at 14 19 ] ] -RRB- cord-333600-k6ws97at 14 20 . . . cord-333600-k6ws97at 15 1 Moreover moreover RB cord-333600-k6ws97at 15 2 , , , cord-333600-k6ws97at 15 3 while while IN cord-333600-k6ws97at 15 4 type type NN cord-333600-k6ws97at 15 5 I -PRON- PRP cord-333600-k6ws97at 15 6 IFNs ifns VBP cord-333600-k6ws97at 15 7 act act VB cord-333600-k6ws97at 15 8 on on IN cord-333600-k6ws97at 15 9 ubiquitously ubiquitously RB cord-333600-k6ws97at 15 10 expressed express VBN cord-333600-k6ws97at 15 11 receptors receptor NNS cord-333600-k6ws97at 15 12 , , , cord-333600-k6ws97at 15 13 type type NN cord-333600-k6ws97at 15 14 III III NNP cord-333600-k6ws97at 15 15 IFN IFN NNP cord-333600-k6ws97at 15 16 action action NN cord-333600-k6ws97at 15 17 is be VBZ cord-333600-k6ws97at 15 18 restricted restrict VBN cord-333600-k6ws97at 15 19 as as IN cord-333600-k6ws97at 15 20 receptors receptor NNS cord-333600-k6ws97at 15 21 are be VBP cord-333600-k6ws97at 15 22 particularly particularly RB cord-333600-k6ws97at 15 23 expressed express VBN cord-333600-k6ws97at 15 24 on on IN cord-333600-k6ws97at 15 25 epithelia epithelium NNS cord-333600-k6ws97at 15 26 , , , cord-333600-k6ws97at 15 27 e.g. e.g. RB cord-333600-k6ws97at 15 28 , , , cord-333600-k6ws97at 15 29 of of IN cord-333600-k6ws97at 15 30 the the DT cord-333600-k6ws97at 15 31 lung lung NN cord-333600-k6ws97at 15 32 . . . cord-333600-k6ws97at 16 1 Type type NN cord-333600-k6ws97at 16 2 III III NNP cord-333600-k6ws97at 16 3 IFN IFN NNP cord-333600-k6ws97at 16 4 induction induction NN cord-333600-k6ws97at 16 5 and and CC cord-333600-k6ws97at 16 6 its -PRON- PRP$ cord-333600-k6ws97at 16 7 effectors effector NNS cord-333600-k6ws97at 16 8 might may MD cord-333600-k6ws97at 16 9 naturally naturally RB cord-333600-k6ws97at 16 10 combat combat VB cord-333600-k6ws97at 16 11 respiratory respiratory JJ cord-333600-k6ws97at 16 12 infections infection NNS cord-333600-k6ws97at 16 13 and and CC cord-333600-k6ws97at 16 14 might may MD cord-333600-k6ws97at 16 15 constitute constitute VB cord-333600-k6ws97at 16 16 a a DT cord-333600-k6ws97at 16 17 promising promising JJ cord-333600-k6ws97at 16 18 therapeutic therapeutic JJ cord-333600-k6ws97at 16 19 target target NN cord-333600-k6ws97at 16 20 pathway pathway NN cord-333600-k6ws97at 16 21 . . . cord-333600-k6ws97at 17 1 A a DT cord-333600-k6ws97at 17 2 common common JJ cord-333600-k6ws97at 17 3 germ germ NN cord-333600-k6ws97at 17 4 line line NN cord-333600-k6ws97at 17 5 genetic genetic JJ cord-333600-k6ws97at 17 6 variation variation NN cord-333600-k6ws97at 17 7 within within IN cord-333600-k6ws97at 17 8 the the DT cord-333600-k6ws97at 17 9 type type NN cord-333600-k6ws97at 17 10 III III NNP cord-333600-k6ws97at 17 11 IFN IFN NNP cord-333600-k6ws97at 17 12 gene gene NN cord-333600-k6ws97at 17 13 locus locus NN cord-333600-k6ws97at 17 14 has have VBZ cord-333600-k6ws97at 17 15 been be VBN cord-333600-k6ws97at 17 16 most most RBS cord-333600-k6ws97at 17 17 convincingly convincingly RB cord-333600-k6ws97at 17 18 shown show VBN cord-333600-k6ws97at 17 19 to to TO cord-333600-k6ws97at 17 20 determine determine VB cord-333600-k6ws97at 17 21 the the DT cord-333600-k6ws97at 17 22 host host NN cord-333600-k6ws97at 17 23 's 's POS cord-333600-k6ws97at 17 24 capacity capacity NN cord-333600-k6ws97at 17 25 to to TO cord-333600-k6ws97at 17 26 cope cope VB cord-333600-k6ws97at 17 27 with with IN cord-333600-k6ws97at 17 28 an an DT cord-333600-k6ws97at 17 29 infection infection NN cord-333600-k6ws97at 17 30 induced induce VBN cord-333600-k6ws97at 17 31 by by IN cord-333600-k6ws97at 17 32 hepatitis hepatitis NN cord-333600-k6ws97at 17 33 C C NNP cord-333600-k6ws97at 17 34 virus virus NN cord-333600-k6ws97at 17 35 ( ( -LRB- cord-333600-k6ws97at 17 36 HCV HCV NNP cord-333600-k6ws97at 17 37 ) ) -RRB- cord-333600-k6ws97at 17 38 , , , cord-333600-k6ws97at 17 39 an an DT cord-333600-k6ws97at 17 40 enveloped envelop VBN cord-333600-k6ws97at 17 41 ssRNA ssrna NN cord-333600-k6ws97at 17 42 virus virus NN cord-333600-k6ws97at 17 43 of of IN cord-333600-k6ws97at 17 44 positive positive JJ cord-333600-k6ws97at 17 45 orientation orientation NN cord-333600-k6ws97at 17 46 , , , cord-333600-k6ws97at 17 47 too too RB cord-333600-k6ws97at 17 48 , , , cord-333600-k6ws97at 17 49 featuring feature VBG cord-333600-k6ws97at 17 50 tropism tropism NN cord-333600-k6ws97at 17 51 for for IN cord-333600-k6ws97at 17 52 liver liver NN cord-333600-k6ws97at 17 53 epithelial epithelial JJ cord-333600-k6ws97at 17 54 cells cell NNS cord-333600-k6ws97at 17 55 . . . cord-333600-k6ws97at 18 1 One one CD cord-333600-k6ws97at 18 2 candidate candidate NN cord-333600-k6ws97at 18 3 variation variation NN cord-333600-k6ws97at 18 4 is be VBZ cord-333600-k6ws97at 18 5 suggested suggest VBN cord-333600-k6ws97at 18 6 to to TO cord-333600-k6ws97at 18 7 be be VB cord-333600-k6ws97at 18 8 a a DT cord-333600-k6ws97at 18 9 dinucleotide dinucleotide NN cord-333600-k6ws97at 18 10 polymorphism polymorphism NN cord-333600-k6ws97at 18 11 within within IN cord-333600-k6ws97at 18 12 the the DT cord-333600-k6ws97at 18 13 the the DT cord-333600-k6ws97at 18 14 host host NN cord-333600-k6ws97at 18 15 's 's POS cord-333600-k6ws97at 18 16 capability capability NN cord-333600-k6ws97at 18 17 to to TO cord-333600-k6ws97at 18 18 encode encode VB cord-333600-k6ws97at 18 19 a a DT cord-333600-k6ws97at 18 20 functional functional JJ cord-333600-k6ws97at 18 21 IFN IFN NNP cord-333600-k6ws97at 18 22 - - HYPH cord-333600-k6ws97at 18 23 λ λ NN cord-333600-k6ws97at 18 24 4 4 CD cord-333600-k6ws97at 18 25 protein protein NN cord-333600-k6ws97at 18 26 [ [ -LRB- cord-333600-k6ws97at 18 27 8 8 CD cord-333600-k6ws97at 18 28 ] ] -RRB- cord-333600-k6ws97at 18 29 . . . cord-333600-k6ws97at 19 1 Paradoxically paradoxically RB cord-333600-k6ws97at 19 2 , , , cord-333600-k6ws97at 19 3 the the DT cord-333600-k6ws97at 19 4 IFNL4 ifnl4 NN cord-333600-k6ws97at 19 5 knockout knockout NN cord-333600-k6ws97at 19 6 variant variant NN cord-333600-k6ws97at 19 7 TT TT NNP cord-333600-k6ws97at 19 8 is be VBZ cord-333600-k6ws97at 19 9 favorable favorable JJ cord-333600-k6ws97at 19 10 for for IN cord-333600-k6ws97at 19 11 virus virus NN cord-333600-k6ws97at 19 12 eradication eradication NN cord-333600-k6ws97at 19 13 and and CC cord-333600-k6ws97at 19 14 resolution resolution NN cord-333600-k6ws97at 19 15 of of IN cord-333600-k6ws97at 19 16 infection infection NN cord-333600-k6ws97at 19 17 , , , cord-333600-k6ws97at 19 18 presumably presumably RB cord-333600-k6ws97at 19 19 by by IN cord-333600-k6ws97at 19 20 the the DT cord-333600-k6ws97at 19 21 deactivation deactivation NN cord-333600-k6ws97at 19 22 of of IN cord-333600-k6ws97at 19 23 an an DT cord-333600-k6ws97at 19 24 IFN IFN NNP cord-333600-k6ws97at 19 25 - - HYPH cord-333600-k6ws97at 19 26 αdesensitizing αdesensitize VBG cord-333600-k6ws97at 19 27 control control NN cord-333600-k6ws97at 19 28 mechanism mechanism NN cord-333600-k6ws97at 19 29 , , , cord-333600-k6ws97at 19 30 antagonizing antagonize VBG cord-333600-k6ws97at 19 31 IFN IFN NNP cord-333600-k6ws97at 19 32 - - HYPH cord-333600-k6ws97at 19 33 α α NNP cord-333600-k6ws97at 19 34 efficacy efficacy NN cord-333600-k6ws97at 19 35 [ [ -LRB- cord-333600-k6ws97at 19 36 9 9 CD cord-333600-k6ws97at 19 37 ] ] -RRB- cord-333600-k6ws97at 19 38 . . . cord-333600-k6ws97at 20 1 Globally globally RB cord-333600-k6ws97at 20 2 , , , cord-333600-k6ws97at 20 3 the the DT cord-333600-k6ws97at 20 4 frequency frequency NN cord-333600-k6ws97at 20 5 of of IN cord-333600-k6ws97at 20 6 the the DT cord-333600-k6ws97at 20 7 favorable favorable JJ cord-333600-k6ws97at 20 8 knockout knockout NN cord-333600-k6ws97at 20 9 variant variant NN cord-333600-k6ws97at 20 10 TT TT NNP cord-333600-k6ws97at 20 11 amounts amount VBZ cord-333600-k6ws97at 20 12 up up IN cord-333600-k6ws97at 20 13 to to IN cord-333600-k6ws97at 20 14 0.841 0.841 CD cord-333600-k6ws97at 20 15 among among IN cord-333600-k6ws97at 20 16 Asian asian JJ cord-333600-k6ws97at 20 17 populations population NNS cord-333600-k6ws97at 20 18 , , , cord-333600-k6ws97at 20 19 which which WDT cord-333600-k6ws97at 20 20 lessens lessen VBZ cord-333600-k6ws97at 20 21 down down RB cord-333600-k6ws97at 20 22 to to IN cord-333600-k6ws97at 20 23 0.689 0.689 CD cord-333600-k6ws97at 20 24 and and CC cord-333600-k6ws97at 20 25 0.293 0.293 CD cord-333600-k6ws97at 20 26 for for IN cord-333600-k6ws97at 20 27 individuals individual NNS cord-333600-k6ws97at 20 28 of of IN cord-333600-k6ws97at 20 29 European european JJ cord-333600-k6ws97at 20 30 or or CC cord-333600-k6ws97at 20 31 African african JJ cord-333600-k6ws97at 20 32 ancestry ancestry NN cord-333600-k6ws97at 20 33 , , , cord-333600-k6ws97at 20 34 respectively respectively RB cord-333600-k6ws97at 20 35 . . . cord-333600-k6ws97at 21 1 Apart apart RB cord-333600-k6ws97at 21 2 from from IN cord-333600-k6ws97at 21 3 national national JJ cord-333600-k6ws97at 21 4 measures measure NNS cord-333600-k6ws97at 21 5 that that WDT cord-333600-k6ws97at 21 6 unambiguously unambiguously RB cord-333600-k6ws97at 21 7 successfully successfully RB cord-333600-k6ws97at 21 8 control control VBP cord-333600-k6ws97at 21 9 viral viral JJ cord-333600-k6ws97at 21 10 spread spread NN cord-333600-k6ws97at 21 11 , , , cord-333600-k6ws97at 21 12 populations population NNS cord-333600-k6ws97at 21 13 might may MD cord-333600-k6ws97at 21 14 differ differ VB cord-333600-k6ws97at 21 15 in in IN cord-333600-k6ws97at 21 16 susceptibility susceptibility NN cord-333600-k6ws97at 21 17 . . . cord-333600-k6ws97at 22 1 Moreover moreover RB cord-333600-k6ws97at 22 2 , , , cord-333600-k6ws97at 22 3 within within IN cord-333600-k6ws97at 22 4 a a DT cord-333600-k6ws97at 22 5 given give VBN cord-333600-k6ws97at 22 6 population population NN cord-333600-k6ws97at 22 7 , , , cord-333600-k6ws97at 22 8 individuals individual NNS cord-333600-k6ws97at 22 9 might may MD cord-333600-k6ws97at 22 10 be be VB cord-333600-k6ws97at 22 11 at at IN cord-333600-k6ws97at 22 12 different different JJ cord-333600-k6ws97at 22 13 risk risk NN cord-333600-k6ws97at 22 14 , , , cord-333600-k6ws97at 22 15 not not RB cord-333600-k6ws97at 22 16 only only RB cord-333600-k6ws97at 22 17 due due IN cord-333600-k6ws97at 22 18 to to IN cord-333600-k6ws97at 22 19 gender gender NN cord-333600-k6ws97at 22 20 or or CC cord-333600-k6ws97at 22 21 age age NN cord-333600-k6ws97at 22 22 [ [ -LRB- cord-333600-k6ws97at 22 23 1 1 CD cord-333600-k6ws97at 22 24 ] ] -RRB- cord-333600-k6ws97at 22 25 . . . cord-333600-k6ws97at 23 1 This this DT cord-333600-k6ws97at 23 2 is be VBZ cord-333600-k6ws97at 23 3 to to TO cord-333600-k6ws97at 23 4 encourage encourage VB cord-333600-k6ws97at 23 5 personalizing personalize VBG cord-333600-k6ws97at 23 6 approaches approach NNS cord-333600-k6ws97at 23 7 considering consider VBG cord-333600-k6ws97at 23 8 the the DT cord-333600-k6ws97at 23 9 genetic genetic JJ cord-333600-k6ws97at 23 10 background background NN cord-333600-k6ws97at 23 11 in in IN cord-333600-k6ws97at 23 12 IFNL IFNL NNP cord-333600-k6ws97at 23 13 genes gene NNS cord-333600-k6ws97at 23 14 as as IN cord-333600-k6ws97at 23 15 a a DT cord-333600-k6ws97at 23 16 hostspecific hostspecific JJ cord-333600-k6ws97at 23 17 indicator indicator NN cord-333600-k6ws97at 23 18 for for IN cord-333600-k6ws97at 23 19 the the DT cord-333600-k6ws97at 23 20 outcome outcome NN cord-333600-k6ws97at 23 21 of of IN cord-333600-k6ws97at 23 22 the the DT cord-333600-k6ws97at 23 23 prevalent prevalent JJ cord-333600-k6ws97at 23 24 RNA RNA NNP cord-333600-k6ws97at 23 25 viral viral JJ cord-333600-k6ws97at 23 26 infections infection NNS cord-333600-k6ws97at 23 27 outside outside RB cord-333600-k6ws97at 23 28 of of IN cord-333600-k6ws97at 23 29 HCV HCV NNP cord-333600-k6ws97at 23 30 . . . cord-333600-k6ws97at 24 1 A a DT cord-333600-k6ws97at 24 2 Novel Novel NNP cord-333600-k6ws97at 24 3 Coronavirus Coronavirus NNP cord-333600-k6ws97at 24 4 from from IN cord-333600-k6ws97at 24 5 Patients patient NNS cord-333600-k6ws97at 24 6 with with IN cord-333600-k6ws97at 24 7 Pneumonia Pneumonia NNP cord-333600-k6ws97at 24 8 in in IN cord-333600-k6ws97at 24 9 China China NNP cord-333600-k6ws97at 25 1 CD200 CD200 NNP cord-333600-k6ws97at 25 2 receptor receptor NN cord-333600-k6ws97at 25 3 controls control VBZ cord-333600-k6ws97at 25 4 sex sex NN cord-333600-k6ws97at 25 5 - - HYPH cord-333600-k6ws97at 25 6 specific specific JJ cord-333600-k6ws97at 25 7 TLR7 TLR7 NNP cord-333600-k6ws97at 25 8 responses response NNS cord-333600-k6ws97at 25 9 to to IN cord-333600-k6ws97at 25 10 viral viral JJ cord-333600-k6ws97at 25 11 infection infection NN cord-333600-k6ws97at 26 1 IFN- IFN- NNP cord-333600-k6ws97at 27 1 I -PRON- PRP cord-333600-k6ws97at 27 2 response response VBP cord-333600-k6ws97at 27 3 timing timing NN cord-333600-k6ws97at 27 4 relative relative JJ cord-333600-k6ws97at 27 5 to to IN cord-333600-k6ws97at 27 6 virus virus NN cord-333600-k6ws97at 27 7 replication replication NN cord-333600-k6ws97at 27 8 determines determine VBZ cord-333600-k6ws97at 27 9 MERS MERS NNP cord-333600-k6ws97at 27 10 coronavirus coronavirus NN cord-333600-k6ws97at 27 11 infection infection NN cord-333600-k6ws97at 27 12 outcomes outcome NNS cord-333600-k6ws97at 28 1 TLR7 TLR7 NNP cord-333600-k6ws97at 28 2 ligands ligand NNS cord-333600-k6ws97at 28 3 induce induce VBP cord-333600-k6ws97at 28 4 higher high JJR cord-333600-k6ws97at 28 5 IFN IFN NNP cord-333600-k6ws97at 28 6 - - HYPH cord-333600-k6ws97at 28 7 alpha alpha NN cord-333600-k6ws97at 28 8 production production NN cord-333600-k6ws97at 28 9 in in IN cord-333600-k6ws97at 28 10 females female NNS cord-333600-k6ws97at 28 11 Sex sex NN cord-333600-k6ws97at 28 12 differences difference NNS cord-333600-k6ws97at 28 13 in in IN cord-333600-k6ws97at 28 14 the the DT cord-333600-k6ws97at 28 15 Toll Toll NNP cord-333600-k6ws97at 28 16 - - HYPH cord-333600-k6ws97at 28 17 like like JJ cord-333600-k6ws97at 28 18 receptor receptor NN cord-333600-k6ws97at 28 19 - - HYPH cord-333600-k6ws97at 28 20 mediated mediate VBN cord-333600-k6ws97at 28 21 response response NN cord-333600-k6ws97at 28 22 of of IN cord-333600-k6ws97at 28 23 plasmacytoid plasmacytoid NNP cord-333600-k6ws97at 28 24 dendritic dendritic JJ cord-333600-k6ws97at 28 25 cells cell NNS cord-333600-k6ws97at 28 26 to to IN cord-333600-k6ws97at 28 27 HIV-1 HIV-1 NNP cord-333600-k6ws97at 29 1 Do do VBP cord-333600-k6ws97at 29 2 men man NNS cord-333600-k6ws97at 29 3 have have VB cord-333600-k6ws97at 29 4 a a DT cord-333600-k6ws97at 29 5 higher high JJR cord-333600-k6ws97at 29 6 case case NN cord-333600-k6ws97at 29 7 fatality fatality NN cord-333600-k6ws97at 29 8 rate rate NN cord-333600-k6ws97at 29 9 of of IN cord-333600-k6ws97at 29 10 severe severe JJ cord-333600-k6ws97at 29 11 acute acute JJ cord-333600-k6ws97at 29 12 respiratory respiratory JJ cord-333600-k6ws97at 29 13 syndrome syndrome NN cord-333600-k6ws97at 29 14 than than IN cord-333600-k6ws97at 29 15 women woman NNS cord-333600-k6ws97at 29 16 do do VBP cord-333600-k6ws97at 29 17 ? ? . cord-333600-k6ws97at 30 1 The the DT cord-333600-k6ws97at 30 2 impact impact NN cord-333600-k6ws97at 30 3 of of IN cord-333600-k6ws97at 30 4 the the DT cord-333600-k6ws97at 30 5 interferonlambda interferonlambda NN cord-333600-k6ws97at 30 6 family family NN cord-333600-k6ws97at 30 7 on on IN cord-333600-k6ws97at 30 8 the the DT cord-333600-k6ws97at 30 9 innate innate JJ cord-333600-k6ws97at 30 10 and and CC cord-333600-k6ws97at 30 11 adaptive adaptive JJ cord-333600-k6ws97at 30 12 immune immune JJ cord-333600-k6ws97at 30 13 response response NN cord-333600-k6ws97at 30 14 to to IN cord-333600-k6ws97at 30 15 viral viral JJ cord-333600-k6ws97at 30 16 infections infection NNS cord-333600-k6ws97at 30 17 A a DT cord-333600-k6ws97at 30 18 variant variant NN cord-333600-k6ws97at 30 19 upstream upstream RB cord-333600-k6ws97at 30 20 of of IN cord-333600-k6ws97at 30 21 IFNL3 ifnl3 XX cord-333600-k6ws97at 31 1 ( ( -LRB- cord-333600-k6ws97at 31 2 IL28B il28b NN cord-333600-k6ws97at 31 3 ) ) -RRB- cord-333600-k6ws97at 31 4 creating create VBG cord-333600-k6ws97at 31 5 a a DT cord-333600-k6ws97at 31 6 new new JJ cord-333600-k6ws97at 31 7 interferon interferon NN cord-333600-k6ws97at 31 8 gene gene NN cord-333600-k6ws97at 31 9 IFNL4 IFNL4 NNP cord-333600-k6ws97at 31 10 is be VBZ cord-333600-k6ws97at 31 11 associated associate VBN cord-333600-k6ws97at 31 12 with with IN cord-333600-k6ws97at 31 13 impaired impaired JJ cord-333600-k6ws97at 31 14 clearance clearance NN cord-333600-k6ws97at 31 15 of of IN cord-333600-k6ws97at 31 16 hepatitis hepatitis NN cord-333600-k6ws97at 31 17 C C NNP cord-333600-k6ws97at 31 18 virus virus NN cord-333600-k6ws97at 31 19 Activation Activation NNP cord-333600-k6ws97at 31 20 of of IN cord-333600-k6ws97at 31 21 Type Type NNP cord-333600-k6ws97at 31 22 I I NNP cord-333600-k6ws97at 31 23 and and CC cord-333600-k6ws97at 31 24 Type Type NNP cord-333600-k6ws97at 31 25 III III NNP cord-333600-k6ws97at 31 26 Interferons Interferons NNPS cord-333600-k6ws97at 31 27 in in IN cord-333600-k6ws97at 31 28 Chronic Chronic NNP cord-333600-k6ws97at 31 29 Hepatitis Hepatitis NNP cord-333600-k6ws97at 31 30 C C NNP cord-333600-k6ws97at 31 31 Not not RB cord-333600-k6ws97at 31 32 applicable applicable JJ cord-333600-k6ws97at 31 33 . . . cord-333600-k6ws97at 32 1 The the DT cord-333600-k6ws97at 32 2 author author NN cord-333600-k6ws97at 32 3 has have VBZ cord-333600-k6ws97at 32 4 no no DT cord-333600-k6ws97at 32 5 conflicts conflict NNS cord-333600-k6ws97at 32 6 of of IN cord-333600-k6ws97at 32 7 interest interest NN cord-333600-k6ws97at 32 8 to to TO cord-333600-k6ws97at 32 9 declare declare VB cord-333600-k6ws97at 32 10 . . . cord-333600-k6ws97at 33 1 This this DT cord-333600-k6ws97at 33 2 publication publication NN cord-333600-k6ws97at 33 3 is be VBZ cord-333600-k6ws97at 33 4 financially financially RB cord-333600-k6ws97at 33 5 supported support VBN cord-333600-k6ws97at 33 6 by by IN cord-333600-k6ws97at 33 7 the the DT cord-333600-k6ws97at 33 8 open open JJ cord-333600-k6ws97at 33 9 access access NN cord-333600-k6ws97at 33 10 publication publication NN cord-333600-k6ws97at 33 11 fund fund NN cord-333600-k6ws97at 33 12 of of IN cord-333600-k6ws97at 33 13 the the DT cord-333600-k6ws97at 33 14 University University NNP cord-333600-k6ws97at 33 15 of of IN cord-333600-k6ws97at 33 16 Göttingen Göttingen NNP cord-333600-k6ws97at 33 17 . . . cord-333600-k6ws97at 34 1 This this DT cord-333600-k6ws97at 34 2 is be VBZ cord-333600-k6ws97at 34 3 a a DT cord-333600-k6ws97at 34 4 single single JJ cord-333600-k6ws97at 34 5 author author NN cord-333600-k6ws97at 34 6 contribution contribution NN cord-333600-k6ws97at 34 7 . . .