id sid tid token lemma pos cord-299949-kmn53e2z 1 1 key key NN cord-299949-kmn53e2z 1 2 : : : cord-299949-kmn53e2z 2 1 cord-299949-kmn53e2z cord-299949-kmn53e2z NNP cord-299949-kmn53e2z 2 2 authors author NNS cord-299949-kmn53e2z 2 3 : : : cord-299949-kmn53e2z 2 4 Schultz Schultz NNP cord-299949-kmn53e2z 2 5 , , , cord-299949-kmn53e2z 2 6 Kimberly Kimberly NNP cord-299949-kmn53e2z 2 7 L.W. L.W. NNP cord-299949-kmn53e2z 2 8 ; ; : cord-299949-kmn53e2z 2 9 Griffin Griffin NNP cord-299949-kmn53e2z 2 10 , , , cord-299949-kmn53e2z 2 11 Diane Diane NNP cord-299949-kmn53e2z 2 12 E. E. NNP cord-299949-kmn53e2z 2 13 title title NN cord-299949-kmn53e2z 2 14 : : : cord-299949-kmn53e2z 2 15 Immune immune JJ cord-299949-kmn53e2z 2 16 Responses response NNS cord-299949-kmn53e2z 2 17 to to IN cord-299949-kmn53e2z 2 18 Viruses virus NNS cord-299949-kmn53e2z 2 19 in in IN cord-299949-kmn53e2z 2 20 the the DT cord-299949-kmn53e2z 2 21 CNS CNS NNP cord-299949-kmn53e2z 2 22 date date NN cord-299949-kmn53e2z 2 23 : : : cord-299949-kmn53e2z 2 24 2016 2016 CD cord-299949-kmn53e2z 2 25 - - HYPH cord-299949-kmn53e2z 2 26 05 05 CD cord-299949-kmn53e2z 2 27 - - HYPH cord-299949-kmn53e2z 2 28 09 09 CD cord-299949-kmn53e2z 2 29 journal journal NN cord-299949-kmn53e2z 2 30 : : : cord-299949-kmn53e2z 2 31 Encyclopedia Encyclopedia NNP cord-299949-kmn53e2z 2 32 of of IN cord-299949-kmn53e2z 2 33 Immunobiology Immunobiology NNP cord-299949-kmn53e2z 2 34 DOI DOI NNP cord-299949-kmn53e2z 2 35 : : : cord-299949-kmn53e2z 2 36 10.1016 10.1016 CD cord-299949-kmn53e2z 2 37 / / SYM cord-299949-kmn53e2z 2 38 b978 b978 NN cord-299949-kmn53e2z 2 39 - - HYPH cord-299949-kmn53e2z 2 40 0 0 CD cord-299949-kmn53e2z 2 41 - - HYPH cord-299949-kmn53e2z 2 42 12 12 CD cord-299949-kmn53e2z 2 43 - - HYPH cord-299949-kmn53e2z 2 44 374279 374279 CD cord-299949-kmn53e2z 2 45 - - HYPH cord-299949-kmn53e2z 2 46 7.14022 7.14022 CD cord-299949-kmn53e2z 2 47 - - SYM cord-299949-kmn53e2z 2 48 6 6 CD cord-299949-kmn53e2z 2 49 sha sha NN cord-299949-kmn53e2z 2 50 : : : cord-299949-kmn53e2z 2 51 fd05d76796d5f8d4e45a6e994a0152dc6c92795b fd05d76796d5f8d4e45a6e994a0152dc6c92795b : cord-299949-kmn53e2z 2 52 doc_id doc_id CD cord-299949-kmn53e2z 2 53 : : : cord-299949-kmn53e2z 2 54 299949 299949 CD cord-299949-kmn53e2z 2 55 cord_uid cord_uid NNS cord-299949-kmn53e2z 2 56 : : : cord-299949-kmn53e2z 2 57 kmn53e2z kmn53e2z NNP cord-299949-kmn53e2z 2 58 For for IN cord-299949-kmn53e2z 2 59 recovery recovery NN cord-299949-kmn53e2z 2 60 from from IN cord-299949-kmn53e2z 2 61 infection infection NN cord-299949-kmn53e2z 2 62 , , , cord-299949-kmn53e2z 3 1 the the DT cord-299949-kmn53e2z 3 2 immune immune JJ cord-299949-kmn53e2z 3 3 response response NN cord-299949-kmn53e2z 3 4 in in IN cord-299949-kmn53e2z 3 5 the the DT cord-299949-kmn53e2z 3 6 central central JJ cord-299949-kmn53e2z 3 7 nervous nervous JJ cord-299949-kmn53e2z 3 8 system system NN cord-299949-kmn53e2z 3 9 ( ( -LRB- cord-299949-kmn53e2z 3 10 CNS CNS NNP cord-299949-kmn53e2z 3 11 ) ) -RRB- cord-299949-kmn53e2z 3 12 must must MD cord-299949-kmn53e2z 3 13 eliminate eliminate VB cord-299949-kmn53e2z 3 14 or or CC cord-299949-kmn53e2z 3 15 control control VB cord-299949-kmn53e2z 3 16 virus virus NN cord-299949-kmn53e2z 3 17 replication replication NN cord-299949-kmn53e2z 3 18 without without IN cord-299949-kmn53e2z 3 19 destroying destroy VBG cord-299949-kmn53e2z 3 20 nonrenewable nonrenewable JJ cord-299949-kmn53e2z 3 21 , , , cord-299949-kmn53e2z 3 22 essential essential JJ cord-299949-kmn53e2z 3 23 cells cell NNS cord-299949-kmn53e2z 3 24 . . . cord-299949-kmn53e2z 4 1 Thus thus RB cord-299949-kmn53e2z 4 2 , , , cord-299949-kmn53e2z 4 3 upon upon IN cord-299949-kmn53e2z 4 4 intracellular intracellular JJ cord-299949-kmn53e2z 4 5 virus virus NN cord-299949-kmn53e2z 4 6 detection detection NN cord-299949-kmn53e2z 4 7 , , , cord-299949-kmn53e2z 4 8 the the DT cord-299949-kmn53e2z 4 9 infected infected JJ cord-299949-kmn53e2z 4 10 cell cell NN cord-299949-kmn53e2z 4 11 must must MD cord-299949-kmn53e2z 4 12 initiate initiate VB cord-299949-kmn53e2z 4 13 clearance clearance NN cord-299949-kmn53e2z 4 14 pathways pathway NNS cord-299949-kmn53e2z 4 15 without without IN cord-299949-kmn53e2z 4 16 triggering trigger VBG cord-299949-kmn53e2z 4 17 neuronal neuronal JJ cord-299949-kmn53e2z 4 18 cell cell NN cord-299949-kmn53e2z 4 19 death death NN cord-299949-kmn53e2z 4 20 . . . cord-299949-kmn53e2z 5 1 As as IN cord-299949-kmn53e2z 5 2 a a DT cord-299949-kmn53e2z 5 3 result result NN cord-299949-kmn53e2z 5 4 , , , cord-299949-kmn53e2z 5 5 the the DT cord-299949-kmn53e2z 5 6 inflammatory inflammatory JJ cord-299949-kmn53e2z 5 7 response response NN cord-299949-kmn53e2z 5 8 must must MD cord-299949-kmn53e2z 5 9 be be VB cord-299949-kmn53e2z 5 10 tightly tightly RB cord-299949-kmn53e2z 5 11 regulated regulated JJ cord-299949-kmn53e2z 5 12 and and CC cord-299949-kmn53e2z 5 13 unique unique JJ cord-299949-kmn53e2z 5 14 mechanisms mechanism NNS cord-299949-kmn53e2z 5 15 contribute contribute VBP cord-299949-kmn53e2z 5 16 to to IN cord-299949-kmn53e2z 5 17 the the DT cord-299949-kmn53e2z 5 18 immune immune JJ cord-299949-kmn53e2z 5 19 response response NN cord-299949-kmn53e2z 5 20 in in IN cord-299949-kmn53e2z 5 21 the the DT cord-299949-kmn53e2z 5 22 CNS CNS NNP cord-299949-kmn53e2z 5 23 . . . cord-299949-kmn53e2z 6 1 Early early JJ cord-299949-kmn53e2z 6 2 restriction restriction NN cord-299949-kmn53e2z 6 3 of of IN cord-299949-kmn53e2z 6 4 virus virus NN cord-299949-kmn53e2z 6 5 replication replication NN cord-299949-kmn53e2z 6 6 is be VBZ cord-299949-kmn53e2z 6 7 accomplished accomplish VBN cord-299949-kmn53e2z 6 8 by by IN cord-299949-kmn53e2z 6 9 the the DT cord-299949-kmn53e2z 6 10 innate innate JJ cord-299949-kmn53e2z 6 11 immune immune JJ cord-299949-kmn53e2z 6 12 response response NN cord-299949-kmn53e2z 6 13 upon upon IN cord-299949-kmn53e2z 6 14 activation activation NN cord-299949-kmn53e2z 6 15 of of IN cord-299949-kmn53e2z 6 16 pattern pattern NN cord-299949-kmn53e2z 6 17 recognition recognition NN cord-299949-kmn53e2z 6 18 receptors receptor NNS cord-299949-kmn53e2z 6 19 in in IN cord-299949-kmn53e2z 6 20 resident resident JJ cord-299949-kmn53e2z 6 21 cells cell NNS cord-299949-kmn53e2z 6 22 . . . cord-299949-kmn53e2z 7 1 Infiltrating infiltrate VBG cord-299949-kmn53e2z 7 2 immune immune JJ cord-299949-kmn53e2z 7 3 cells cell NNS cord-299949-kmn53e2z 7 4 enter enter VBP cord-299949-kmn53e2z 7 5 from from IN cord-299949-kmn53e2z 7 6 the the DT cord-299949-kmn53e2z 7 7 periphery periphery NN cord-299949-kmn53e2z 7 8 to to IN cord-299949-kmn53e2z 7 9 clear clear JJ cord-299949-kmn53e2z 7 10 virus virus NN cord-299949-kmn53e2z 7 11 . . . cord-299949-kmn53e2z 8 1 Antibodies antibody NNS cord-299949-kmn53e2z 8 2 and and CC cord-299949-kmn53e2z 8 3 interferon interferon NN cord-299949-kmn53e2z 8 4 - - HYPH cord-299949-kmn53e2z 8 5 γ γ NN cord-299949-kmn53e2z 8 6 are be VBP cord-299949-kmn53e2z 8 7 primary primary JJ cord-299949-kmn53e2z 8 8 contributors contributor NNS cord-299949-kmn53e2z 8 9 to to IN cord-299949-kmn53e2z 8 10 noncytolytic noncytolytic JJ cord-299949-kmn53e2z 8 11 clearance clearance NN cord-299949-kmn53e2z 8 12 of of IN cord-299949-kmn53e2z 8 13 virus virus NN cord-299949-kmn53e2z 8 14 in in IN cord-299949-kmn53e2z 8 15 the the DT cord-299949-kmn53e2z 8 16 CNS CNS NNP cord-299949-kmn53e2z 8 17 . . . cord-299949-kmn53e2z 9 1 Lymphocytes lymphocyte NNS cord-299949-kmn53e2z 9 2 are be VBP cord-299949-kmn53e2z 9 3 retained retain VBN cord-299949-kmn53e2z 9 4 in in IN cord-299949-kmn53e2z 9 5 the the DT cord-299949-kmn53e2z 9 6 CNS CNS NNP cord-299949-kmn53e2z 9 7 after after IN cord-299949-kmn53e2z 9 8 the the DT cord-299949-kmn53e2z 9 9 acute acute JJ cord-299949-kmn53e2z 9 10 phase phase NN cord-299949-kmn53e2z 9 11 of of IN cord-299949-kmn53e2z 9 12 infection infection NN cord-299949-kmn53e2z 9 13 presumably presumably RB cord-299949-kmn53e2z 9 14 to to TO cord-299949-kmn53e2z 9 15 block block VB cord-299949-kmn53e2z 9 16 reactivation reactivation NN cord-299949-kmn53e2z 9 17 of of IN cord-299949-kmn53e2z 9 18 virus virus NN cord-299949-kmn53e2z 9 19 replication replication NN cord-299949-kmn53e2z 9 20 . . . cord-299949-kmn53e2z 10 1 For for IN cord-299949-kmn53e2z 10 2 recovery recovery NN cord-299949-kmn53e2z 10 3 after after IN cord-299949-kmn53e2z 10 4 virus virus NN cord-299949-kmn53e2z 10 5 infection infection NN cord-299949-kmn53e2z 10 6 of of IN cord-299949-kmn53e2z 10 7 the the DT cord-299949-kmn53e2z 10 8 central central JJ cord-299949-kmn53e2z 10 9 nervous nervous JJ cord-299949-kmn53e2z 10 10 system system NN cord-299949-kmn53e2z 10 11 ( ( -LRB- cord-299949-kmn53e2z 10 12 CNS CNS NNP cord-299949-kmn53e2z 10 13 ) ) -RRB- cord-299949-kmn53e2z 10 14 , , , cord-299949-kmn53e2z 10 15 the the DT cord-299949-kmn53e2z 10 16 essential essential JJ cord-299949-kmn53e2z 10 17 , , , cord-299949-kmn53e2z 10 18 nonrenewable nonrenewable JJ cord-299949-kmn53e2z 10 19 nature nature NN cord-299949-kmn53e2z 10 20 of of IN cord-299949-kmn53e2z 10 21 neurons neuron NNS cord-299949-kmn53e2z 10 22 requires require VBZ cord-299949-kmn53e2z 10 23 a a DT cord-299949-kmn53e2z 10 24 fine fine RB cord-299949-kmn53e2z 10 25 - - HYPH cord-299949-kmn53e2z 10 26 tuned tune VBN cord-299949-kmn53e2z 10 27 immune immune JJ cord-299949-kmn53e2z 10 28 response response NN cord-299949-kmn53e2z 10 29 that that WDT cord-299949-kmn53e2z 10 30 controls control VBZ cord-299949-kmn53e2z 10 31 virus virus NN cord-299949-kmn53e2z 10 32 replication replication NN cord-299949-kmn53e2z 10 33 without without IN cord-299949-kmn53e2z 10 34 damaging damaging JJ cord-299949-kmn53e2z 10 35 neuronal neuronal JJ cord-299949-kmn53e2z 10 36 function function NN cord-299949-kmn53e2z 10 37 . . . cord-299949-kmn53e2z 11 1 Damage damage NN cord-299949-kmn53e2z 11 2 can can MD cord-299949-kmn53e2z 11 3 result result VB cord-299949-kmn53e2z 11 4 directly directly RB cord-299949-kmn53e2z 11 5 from from IN cord-299949-kmn53e2z 11 6 virus virus NN cord-299949-kmn53e2z 11 7 replication replication NN cord-299949-kmn53e2z 11 8 or or CC cord-299949-kmn53e2z 11 9 from from IN cord-299949-kmn53e2z 11 10 the the DT cord-299949-kmn53e2z 11 11 host host NN cord-299949-kmn53e2z 11 12 immune immune JJ cord-299949-kmn53e2z 11 13 response response NN cord-299949-kmn53e2z 11 14 to to IN cord-299949-kmn53e2z 11 15 infection infection NN cord-299949-kmn53e2z 11 16 . . . cord-299949-kmn53e2z 12 1 Functional functional JJ cord-299949-kmn53e2z 12 2 impairment impairment NN cord-299949-kmn53e2z 12 3 or or CC cord-299949-kmn53e2z 12 4 loss loss NN cord-299949-kmn53e2z 12 5 of of IN cord-299949-kmn53e2z 12 6 neurons neuron NNS cord-299949-kmn53e2z 12 7 following follow VBG cord-299949-kmn53e2z 12 8 infection infection NN cord-299949-kmn53e2z 12 9 can can MD cord-299949-kmn53e2z 12 10 be be VB cord-299949-kmn53e2z 12 11 fatal fatal JJ cord-299949-kmn53e2z 12 12 or or CC cord-299949-kmn53e2z 12 13 leave leave VB cord-299949-kmn53e2z 12 14 survivors survivor NNS cord-299949-kmn53e2z 12 15 with with IN cord-299949-kmn53e2z 12 16 neurological neurological JJ cord-299949-kmn53e2z 12 17 sequelae sequela NNS cord-299949-kmn53e2z 12 18 including include VBG cord-299949-kmn53e2z 12 19 cognitive cognitive JJ cord-299949-kmn53e2z 12 20 deficits deficit NNS cord-299949-kmn53e2z 12 21 , , , cord-299949-kmn53e2z 12 22 seizures seizure NNS cord-299949-kmn53e2z 12 23 , , , cord-299949-kmn53e2z 12 24 or or CC cord-299949-kmn53e2z 12 25 paralysis paralysis NN cord-299949-kmn53e2z 12 26 ( ( -LRB- cord-299949-kmn53e2z 12 27 Hart Hart NNP cord-299949-kmn53e2z 12 28 et et NNP cord-299949-kmn53e2z 12 29 al al NNP cord-299949-kmn53e2z 12 30 . . . cord-299949-kmn53e2z 13 1 , , , cord-299949-kmn53e2z 13 2 2014 2014 CD cord-299949-kmn53e2z 13 3 ; ; : cord-299949-kmn53e2z 13 4 Griffiths Griffiths NNP cord-299949-kmn53e2z 13 5 et et NNP cord-299949-kmn53e2z 13 6 al al NNP cord-299949-kmn53e2z 13 7 . . NNP cord-299949-kmn53e2z 13 8 , , , cord-299949-kmn53e2z 13 9 2013 2013 CD cord-299949-kmn53e2z 13 10 ; ; : cord-299949-kmn53e2z 13 11 Silverman Silverman NNP cord-299949-kmn53e2z 13 12 et et NNP cord-299949-kmn53e2z 13 13 al al NNP cord-299949-kmn53e2z 13 14 . . NNP cord-299949-kmn53e2z 13 15 , , , cord-299949-kmn53e2z 13 16 2013 2013 CD cord-299949-kmn53e2z 13 17 ; ; : cord-299949-kmn53e2z 14 1 Ooi Ooi NNP cord-299949-kmn53e2z 14 2 et et NNP cord-299949-kmn53e2z 14 3 al al NNP cord-299949-kmn53e2z 14 4 . . NNP cord-299949-kmn53e2z 14 5 , , , cord-299949-kmn53e2z 14 6 2008 2008 CD cord-299949-kmn53e2z 14 7 ; ; : cord-299949-kmn53e2z 14 8 Sauder Sauder NNP cord-299949-kmn53e2z 14 9 et et FW cord-299949-kmn53e2z 14 10 al al NNP cord-299949-kmn53e2z 14 11 . . NNP cord-299949-kmn53e2z 14 12 , , , cord-299949-kmn53e2z 14 13 2001 2001 CD cord-299949-kmn53e2z 14 14 ; ; : cord-299949-kmn53e2z 14 15 Finley Finley NNP cord-299949-kmn53e2z 14 16 et et NNP cord-299949-kmn53e2z 14 17 al al NNP cord-299949-kmn53e2z 14 18 . . NNP cord-299949-kmn53e2z 14 19 , , , cord-299949-kmn53e2z 14 20 1955 1955 CD cord-299949-kmn53e2z 14 21 ) ) -RRB- cord-299949-kmn53e2z 14 22 . . . cord-299949-kmn53e2z 15 1 Thus thus RB cord-299949-kmn53e2z 15 2 , , , cord-299949-kmn53e2z 15 3 the the DT cord-299949-kmn53e2z 15 4 immune immune JJ cord-299949-kmn53e2z 15 5 responses response NNS cord-299949-kmn53e2z 15 6 required require VBN cord-299949-kmn53e2z 15 7 for for IN cord-299949-kmn53e2z 15 8 successful successful JJ cord-299949-kmn53e2z 15 9 clearance clearance NN cord-299949-kmn53e2z 15 10 and and CC cord-299949-kmn53e2z 15 11 control control NN cord-299949-kmn53e2z 15 12 of of IN cord-299949-kmn53e2z 15 13 virus virus NN cord-299949-kmn53e2z 15 14 infections infection NNS cord-299949-kmn53e2z 15 15 in in IN cord-299949-kmn53e2z 15 16 the the DT cord-299949-kmn53e2z 15 17 CNS CNS NNP cord-299949-kmn53e2z 15 18 are be VBP cord-299949-kmn53e2z 15 19 often often RB cord-299949-kmn53e2z 15 20 distinct distinct JJ cord-299949-kmn53e2z 15 21 from from IN cord-299949-kmn53e2z 15 22 those those DT cord-299949-kmn53e2z 15 23 required require VBN cord-299949-kmn53e2z 15 24 for for IN cord-299949-kmn53e2z 15 25 clearance clearance NN cord-299949-kmn53e2z 15 26 from from IN cord-299949-kmn53e2z 15 27 other other JJ cord-299949-kmn53e2z 15 28 organs organ NNS cord-299949-kmn53e2z 15 29 and and CC cord-299949-kmn53e2z 15 30 are be VBP cord-299949-kmn53e2z 15 31 characterized characterize VBN cord-299949-kmn53e2z 15 32 by by IN cord-299949-kmn53e2z 15 33 noncytolytic noncytolytic JJ cord-299949-kmn53e2z 15 34 , , , cord-299949-kmn53e2z 15 35 virus virus NN cord-299949-kmn53e2z 15 36 - - HYPH cord-299949-kmn53e2z 15 37 specific specific JJ cord-299949-kmn53e2z 15 38 processes process NNS cord-299949-kmn53e2z 15 39 . . . cord-299949-kmn53e2z 16 1 This this DT cord-299949-kmn53e2z 16 2 strategy strategy NN cord-299949-kmn53e2z 16 3 preserves preserve VBZ cord-299949-kmn53e2z 16 4 CNS CNS NNP cord-299949-kmn53e2z 16 5 function function NN cord-299949-kmn53e2z 16 6 and and CC cord-299949-kmn53e2z 16 7 minimizes minimize VBZ cord-299949-kmn53e2z 16 8 the the DT cord-299949-kmn53e2z 16 9 likelihood likelihood NN cord-299949-kmn53e2z 16 10 of of IN cord-299949-kmn53e2z 16 11 autoimmunity autoimmunity NN cord-299949-kmn53e2z 16 12 . . . cord-299949-kmn53e2z 17 1 Many many JJ cord-299949-kmn53e2z 17 2 viruses virus NNS cord-299949-kmn53e2z 17 3 can can MD cord-299949-kmn53e2z 17 4 infect infect VB cord-299949-kmn53e2z 17 5 the the DT cord-299949-kmn53e2z 17 6 CNS CNS NNP cord-299949-kmn53e2z 17 7 , , , cord-299949-kmn53e2z 17 8 including include VBG cord-299949-kmn53e2z 17 9 DNA dna NN cord-299949-kmn53e2z 17 10 viruses virus NNS cord-299949-kmn53e2z 17 11 , , , cord-299949-kmn53e2z 17 12 plus plus NN cord-299949-kmn53e2z 17 13 - - HYPH cord-299949-kmn53e2z 17 14 and and CC cord-299949-kmn53e2z 17 15 minus minus JJ cord-299949-kmn53e2z 17 16 - - HYPH cord-299949-kmn53e2z 17 17 strand strand NN cord-299949-kmn53e2z 17 18 RNA RNA NNP cord-299949-kmn53e2z 17 19 viruses virus NNS cord-299949-kmn53e2z 17 20 , , , cord-299949-kmn53e2z 17 21 and and CC cord-299949-kmn53e2z 17 22 retroviruses retrovirus NNS cord-299949-kmn53e2z 17 23 , , , cord-299949-kmn53e2z 17 24 leading lead VBG cord-299949-kmn53e2z 17 25 to to IN cord-299949-kmn53e2z 17 26 varying vary VBG cord-299949-kmn53e2z 17 27 outcomes outcome NNS cord-299949-kmn53e2z 17 28 from from IN cord-299949-kmn53e2z 17 29 disease disease NN cord-299949-kmn53e2z 17 30 . . . cord-299949-kmn53e2z 18 1 DNA dna NN cord-299949-kmn53e2z 18 2 viruses virus NNS cord-299949-kmn53e2z 18 3 , , , cord-299949-kmn53e2z 18 4 such such JJ cord-299949-kmn53e2z 18 5 as as IN cord-299949-kmn53e2z 18 6 herpesviruses herpesviruses NNP cord-299949-kmn53e2z 18 7 ( ( -LRB- cord-299949-kmn53e2z 18 8 reviewed review VBN cord-299949-kmn53e2z 18 9 in in IN cord-299949-kmn53e2z 18 10 Koyuncu Koyuncu NNP cord-299949-kmn53e2z 18 11 et et NNP cord-299949-kmn53e2z 18 12 al al NNP cord-299949-kmn53e2z 18 13 . . NNP cord-299949-kmn53e2z 18 14 , , , cord-299949-kmn53e2z 18 15 2013 2013 CD cord-299949-kmn53e2z 18 16 ) ) -RRB- cord-299949-kmn53e2z 18 17 , , , cord-299949-kmn53e2z 18 18 often often RB cord-299949-kmn53e2z 18 19 establish establish VB cord-299949-kmn53e2z 18 20 a a DT cord-299949-kmn53e2z 18 21 latent latent JJ cord-299949-kmn53e2z 18 22 infection infection NN cord-299949-kmn53e2z 18 23 as as IN cord-299949-kmn53e2z 18 24 opposed oppose VBN cord-299949-kmn53e2z 18 25 to to IN cord-299949-kmn53e2z 18 26 RNA RNA NNP cord-299949-kmn53e2z 18 27 viruses virus NNS cord-299949-kmn53e2z 18 28 that that WDT cord-299949-kmn53e2z 18 29 generally generally RB cord-299949-kmn53e2z 18 30 lack lack VBP cord-299949-kmn53e2z 18 31 a a DT cord-299949-kmn53e2z 18 32 nuclear nuclear JJ cord-299949-kmn53e2z 18 33 phase phase NN cord-299949-kmn53e2z 18 34 for for IN cord-299949-kmn53e2z 18 35 their -PRON- PRP$ cord-299949-kmn53e2z 18 36 replication replication NN cord-299949-kmn53e2z 18 37 cycle cycle NN cord-299949-kmn53e2z 18 38 and and CC cord-299949-kmn53e2z 18 39 cause cause VB cord-299949-kmn53e2z 18 40 acute acute JJ cord-299949-kmn53e2z 18 41 disease disease NN cord-299949-kmn53e2z 18 42 . . . cord-299949-kmn53e2z 19 1 In in IN cord-299949-kmn53e2z 19 2 this this DT cord-299949-kmn53e2z 19 3 article article NN cord-299949-kmn53e2z 19 4 , , , cord-299949-kmn53e2z 19 5 we -PRON- PRP cord-299949-kmn53e2z 19 6 will will MD cord-299949-kmn53e2z 19 7 focus focus VB cord-299949-kmn53e2z 19 8 on on IN cord-299949-kmn53e2z 19 9 RNA RNA NNP cord-299949-kmn53e2z 19 10 virus virus NN cord-299949-kmn53e2z 19 11 infections infection NNS cord-299949-kmn53e2z 19 12 in in IN cord-299949-kmn53e2z 19 13 the the DT cord-299949-kmn53e2z 19 14 CNS CNS NNP cord-299949-kmn53e2z 19 15 ( ( -LRB- cord-299949-kmn53e2z 19 16 Table table NN cord-299949-kmn53e2z 19 17 1 1 CD cord-299949-kmn53e2z 19 18 ) ) -RRB- cord-299949-kmn53e2z 19 19 . . . cord-299949-kmn53e2z 20 1 Much much JJ cord-299949-kmn53e2z 20 2 of of IN cord-299949-kmn53e2z 20 3 our -PRON- PRP$ cord-299949-kmn53e2z 20 4 knowledge knowledge NN cord-299949-kmn53e2z 20 5 about about IN cord-299949-kmn53e2z 20 6 the the DT cord-299949-kmn53e2z 20 7 immune immune JJ cord-299949-kmn53e2z 20 8 response response NN cord-299949-kmn53e2z 20 9 to to IN cord-299949-kmn53e2z 20 10 neurotropic neurotropic NNP cord-299949-kmn53e2z 20 11 viruses virus NNS cord-299949-kmn53e2z 20 12 comes come VBZ cord-299949-kmn53e2z 20 13 from from IN cord-299949-kmn53e2z 20 14 studying study VBG cord-299949-kmn53e2z 20 15 well well RB cord-299949-kmn53e2z 20 16 - - HYPH cord-299949-kmn53e2z 20 17 characterized characterize VBN cord-299949-kmn53e2z 20 18 mouse mouse NN cord-299949-kmn53e2z 20 19 models model NNS cord-299949-kmn53e2z 20 20 of of IN cord-299949-kmn53e2z 20 21 infection infection NN cord-299949-kmn53e2z 20 22 . . . cord-299949-kmn53e2z 21 1 Studies study NNS cord-299949-kmn53e2z 21 2 have have VBP cord-299949-kmn53e2z 21 3 investigated investigate VBN cord-299949-kmn53e2z 21 4 the the DT cord-299949-kmn53e2z 21 5 course course NN cord-299949-kmn53e2z 21 6 of of IN cord-299949-kmn53e2z 21 7 disease disease NN cord-299949-kmn53e2z 21 8 and and CC cord-299949-kmn53e2z 21 9 immune immune JJ cord-299949-kmn53e2z 21 10 response response NN cord-299949-kmn53e2z 21 11 both both CC cord-299949-kmn53e2z 21 12 in in IN cord-299949-kmn53e2z 21 13 immunocompetent immunocompetent JJ cord-299949-kmn53e2z 21 14 mice mouse NNS cord-299949-kmn53e2z 21 15 and and CC cord-299949-kmn53e2z 21 16 animals animal NNS cord-299949-kmn53e2z 21 17 deficient deficient JJ cord-299949-kmn53e2z 21 18 in in IN cord-299949-kmn53e2z 21 19 specific specific JJ cord-299949-kmn53e2z 21 20 components component NNS cord-299949-kmn53e2z 21 21 of of IN cord-299949-kmn53e2z 21 22 the the DT cord-299949-kmn53e2z 21 23 immune immune JJ cord-299949-kmn53e2z 21 24 response response NN cord-299949-kmn53e2z 21 25 . . . cord-299949-kmn53e2z 22 1 These these DT cord-299949-kmn53e2z 22 2 studies study NNS cord-299949-kmn53e2z 22 3 have have VBP cord-299949-kmn53e2z 22 4 provided provide VBN cord-299949-kmn53e2z 22 5 detailed detailed JJ cord-299949-kmn53e2z 22 6 knowledge knowledge NN cord-299949-kmn53e2z 22 7 of of IN cord-299949-kmn53e2z 22 8 the the DT cord-299949-kmn53e2z 22 9 role role NN cord-299949-kmn53e2z 22 10 of of IN cord-299949-kmn53e2z 22 11 each each DT cord-299949-kmn53e2z 22 12 arm arm NN cord-299949-kmn53e2z 22 13 of of IN cord-299949-kmn53e2z 22 14 the the DT cord-299949-kmn53e2z 22 15 immune immune JJ cord-299949-kmn53e2z 22 16 response response NN cord-299949-kmn53e2z 22 17 in in IN cord-299949-kmn53e2z 22 18 control control NN cord-299949-kmn53e2z 22 19 of of IN cord-299949-kmn53e2z 22 20 virus virus NN cord-299949-kmn53e2z 22 21 replication replication NN cord-299949-kmn53e2z 22 22 and and CC cord-299949-kmn53e2z 22 23 spread spread NN cord-299949-kmn53e2z 22 24 , , , cord-299949-kmn53e2z 22 25 virus virus NN cord-299949-kmn53e2z 22 26 clearance clearance NN cord-299949-kmn53e2z 22 27 , , , cord-299949-kmn53e2z 22 28 and and CC cord-299949-kmn53e2z 22 29 in in IN cord-299949-kmn53e2z 22 30 immunopathology immunopathology NN cord-299949-kmn53e2z 22 31 . . . cord-299949-kmn53e2z 23 1 In in IN cord-299949-kmn53e2z 23 2 all all DT cord-299949-kmn53e2z 23 3 infections infection NNS cord-299949-kmn53e2z 23 4 , , , cord-299949-kmn53e2z 23 5 outcome outcome NN cord-299949-kmn53e2z 23 6 of of IN cord-299949-kmn53e2z 23 7 infection infection NN cord-299949-kmn53e2z 23 8 is be VBZ cord-299949-kmn53e2z 23 9 dependent dependent JJ cord-299949-kmn53e2z 23 10 on on IN cord-299949-kmn53e2z 23 11 the the DT cord-299949-kmn53e2z 23 12 age age NN cord-299949-kmn53e2z 23 13 and and CC cord-299949-kmn53e2z 23 14 genetic genetic JJ cord-299949-kmn53e2z 23 15 background background NN cord-299949-kmn53e2z 23 16 of of IN cord-299949-kmn53e2z 23 17 the the DT cord-299949-kmn53e2z 23 18 mouse mouse NN cord-299949-kmn53e2z 23 19 and and CC cord-299949-kmn53e2z 23 20 the the DT cord-299949-kmn53e2z 23 21 strain strain NN cord-299949-kmn53e2z 23 22 of of IN cord-299949-kmn53e2z 23 23 the the DT cord-299949-kmn53e2z 23 24 virus virus NN cord-299949-kmn53e2z 23 25 used use VBN cord-299949-kmn53e2z 23 26 . . . cord-299949-kmn53e2z 24 1 For for IN cord-299949-kmn53e2z 24 2 simplicity simplicity NN cord-299949-kmn53e2z 24 3 , , , cord-299949-kmn53e2z 24 4 we -PRON- PRP cord-299949-kmn53e2z 24 5 will will MD cord-299949-kmn53e2z 24 6 focus focus VB cord-299949-kmn53e2z 24 7 on on IN cord-299949-kmn53e2z 24 8 the the DT cord-299949-kmn53e2z 24 9 most most RBS cord-299949-kmn53e2z 24 10 commonly commonly RB cord-299949-kmn53e2z 24 11 studied study VBN cord-299949-kmn53e2z 24 12 strains strain NNS cord-299949-kmn53e2z 24 13 of of IN cord-299949-kmn53e2z 24 14 each each DT cord-299949-kmn53e2z 24 15 virus virus NN cord-299949-kmn53e2z 24 16 family family NN cord-299949-kmn53e2z 24 17 and and CC cord-299949-kmn53e2z 24 18 infection infection NN cord-299949-kmn53e2z 24 19 of of IN cord-299949-kmn53e2z 24 20 mature mature JJ cord-299949-kmn53e2z 24 21 mice mouse NNS cord-299949-kmn53e2z 24 22 . . . cord-299949-kmn53e2z 25 1 Detailed detailed JJ cord-299949-kmn53e2z 25 2 studies study NNS cord-299949-kmn53e2z 25 3 of of IN cord-299949-kmn53e2z 25 4 immune immune JJ cord-299949-kmn53e2z 25 5 responses response NNS cord-299949-kmn53e2z 25 6 to to IN cord-299949-kmn53e2z 25 7 neurotropic neurotropic NNP cord-299949-kmn53e2z 25 8 viruses virus NNS cord-299949-kmn53e2z 25 9 have have VBP cord-299949-kmn53e2z 25 10 included include VBN cord-299949-kmn53e2z 25 11 neuronal neuronal JJ cord-299949-kmn53e2z 25 12 infections infection NNS cord-299949-kmn53e2z 25 13 with with IN cord-299949-kmn53e2z 25 14 rabies rabie NNS cord-299949-kmn53e2z 25 15 virus virus NN cord-299949-kmn53e2z 25 16 , , , cord-299949-kmn53e2z 25 17 flaviviruses flavivirus NNS cord-299949-kmn53e2z 25 18 , , , cord-299949-kmn53e2z 25 19 and and CC cord-299949-kmn53e2z 25 20 alphaviruses alphaviruses NNP cord-299949-kmn53e2z 25 21 , , , cord-299949-kmn53e2z 25 22 as as RB cord-299949-kmn53e2z 25 23 well well RB cord-299949-kmn53e2z 25 24 as as IN cord-299949-kmn53e2z 25 25 infection infection NN cord-299949-kmn53e2z 25 26 of of IN cord-299949-kmn53e2z 25 27 multiple multiple JJ cord-299949-kmn53e2z 25 28 cell cell NN cord-299949-kmn53e2z 25 29 types type NNS cord-299949-kmn53e2z 25 30 with with IN cord-299949-kmn53e2z 25 31 natural natural JJ cord-299949-kmn53e2z 25 32 mouse mouse NN cord-299949-kmn53e2z 25 33 pathogens pathogen NNS cord-299949-kmn53e2z 25 34 such such JJ cord-299949-kmn53e2z 25 35 as as IN cord-299949-kmn53e2z 25 36 Theiler Theiler NNP cord-299949-kmn53e2z 25 37 's 's POS cord-299949-kmn53e2z 25 38 murine murine JJ cord-299949-kmn53e2z 25 39 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 25 40 virus virus NN cord-299949-kmn53e2z 25 41 ( ( -LRB- cord-299949-kmn53e2z 25 42 TMEV TMEV NNP cord-299949-kmn53e2z 25 43 ) ) -RRB- cord-299949-kmn53e2z 25 44 , , , cord-299949-kmn53e2z 25 45 mouse mouse NNP cord-299949-kmn53e2z 25 46 hepatitis hepatitis NN cord-299949-kmn53e2z 25 47 virus virus NN cord-299949-kmn53e2z 25 48 ( ( -LRB- cord-299949-kmn53e2z 25 49 MHV MHV NNP cord-299949-kmn53e2z 25 50 ) ) -RRB- cord-299949-kmn53e2z 25 51 , , , cord-299949-kmn53e2z 25 52 and and CC cord-299949-kmn53e2z 25 53 lymphocytic lymphocytic JJ cord-299949-kmn53e2z 25 54 choriomeningitis choriomeningitis NNP cord-299949-kmn53e2z 25 55 virus virus NN cord-299949-kmn53e2z 25 56 ( ( -LRB- cord-299949-kmn53e2z 25 57 LCMV LCMV NNP cord-299949-kmn53e2z 25 58 ) ) -RRB- cord-299949-kmn53e2z 25 59 . . . cord-299949-kmn53e2z 26 1 The the DT cord-299949-kmn53e2z 26 2 immunological immunological JJ cord-299949-kmn53e2z 26 3 processes process NNS cord-299949-kmn53e2z 26 4 required require VBN cord-299949-kmn53e2z 26 5 for for IN cord-299949-kmn53e2z 26 6 virus virus NN cord-299949-kmn53e2z 26 7 clearance clearance NN cord-299949-kmn53e2z 26 8 from from IN cord-299949-kmn53e2z 26 9 the the DT cord-299949-kmn53e2z 26 10 CNS CNS NNP cord-299949-kmn53e2z 26 11 are be VBP cord-299949-kmn53e2z 26 12 cell cell NN cord-299949-kmn53e2z 26 13 type type NN cord-299949-kmn53e2z 26 14 and and CC cord-299949-kmn53e2z 26 15 virus virus NN cord-299949-kmn53e2z 26 16 specific specific JJ cord-299949-kmn53e2z 26 17 . . . cord-299949-kmn53e2z 27 1 Experimental experimental JJ cord-299949-kmn53e2z 27 2 approaches approach NNS cord-299949-kmn53e2z 27 3 to to TO cord-299949-kmn53e2z 27 4 define define VB cord-299949-kmn53e2z 27 5 these these DT cord-299949-kmn53e2z 27 6 clearance clearance NN cord-299949-kmn53e2z 27 7 mechanisms mechanism NNS cord-299949-kmn53e2z 27 8 are be VBP cord-299949-kmn53e2z 27 9 dependent dependent JJ cord-299949-kmn53e2z 27 10 on on IN cord-299949-kmn53e2z 27 11 the the DT cord-299949-kmn53e2z 27 12 transient transient JJ cord-299949-kmn53e2z 27 13 depletion depletion NN cord-299949-kmn53e2z 27 14 of of IN cord-299949-kmn53e2z 27 15 specific specific JJ cord-299949-kmn53e2z 27 16 immune immune JJ cord-299949-kmn53e2z 27 17 cell cell NN cord-299949-kmn53e2z 27 18 populations population NNS cord-299949-kmn53e2z 27 19 and and CC cord-299949-kmn53e2z 27 20 on on IN cord-299949-kmn53e2z 27 21 the the DT cord-299949-kmn53e2z 27 22 use use NN cord-299949-kmn53e2z 27 23 of of IN cord-299949-kmn53e2z 27 24 mice mouse NNS cord-299949-kmn53e2z 27 25 that that WDT cord-299949-kmn53e2z 27 26 have have VBP cord-299949-kmn53e2z 27 27 selective selective JJ cord-299949-kmn53e2z 27 28 deficiencies deficiency NNS cord-299949-kmn53e2z 27 29 in in IN cord-299949-kmn53e2z 27 30 various various JJ cord-299949-kmn53e2z 27 31 components component NNS cord-299949-kmn53e2z 27 32 of of IN cord-299949-kmn53e2z 27 33 the the DT cord-299949-kmn53e2z 27 34 immune immune JJ cord-299949-kmn53e2z 27 35 system system NN cord-299949-kmn53e2z 27 36 . . . cord-299949-kmn53e2z 28 1 Because because IN cord-299949-kmn53e2z 28 2 of of IN cord-299949-kmn53e2z 28 3 the the DT cord-299949-kmn53e2z 28 4 interdependent interdependent JJ cord-299949-kmn53e2z 28 5 relationships relationship NNS cord-299949-kmn53e2z 28 6 of of IN cord-299949-kmn53e2z 28 7 components component NNS cord-299949-kmn53e2z 28 8 of of IN cord-299949-kmn53e2z 28 9 the the DT cord-299949-kmn53e2z 28 10 immune immune JJ cord-299949-kmn53e2z 28 11 system system NN cord-299949-kmn53e2z 28 12 in in IN cord-299949-kmn53e2z 28 13 the the DT cord-299949-kmn53e2z 28 14 development development NN cord-299949-kmn53e2z 28 15 of of IN cord-299949-kmn53e2z 28 16 an an DT cord-299949-kmn53e2z 28 17 immune immune JJ cord-299949-kmn53e2z 28 18 response response NN cord-299949-kmn53e2z 28 19 , , , cord-299949-kmn53e2z 28 20 deficiencies deficiency NNS cord-299949-kmn53e2z 28 21 of of IN cord-299949-kmn53e2z 28 22 one one CD cord-299949-kmn53e2z 28 23 type type NN cord-299949-kmn53e2z 28 24 of of IN cord-299949-kmn53e2z 28 25 cell cell NN cord-299949-kmn53e2z 28 26 or or CC cord-299949-kmn53e2z 28 27 molecule molecule NN cord-299949-kmn53e2z 28 28 may may MD cord-299949-kmn53e2z 28 29 affect affect VB cord-299949-kmn53e2z 28 30 several several JJ cord-299949-kmn53e2z 28 31 facets facet NNS cord-299949-kmn53e2z 28 32 of of IN cord-299949-kmn53e2z 28 33 the the DT cord-299949-kmn53e2z 28 34 immune immune JJ cord-299949-kmn53e2z 28 35 response response NN cord-299949-kmn53e2z 28 36 , , , cord-299949-kmn53e2z 28 37 making make VBG cord-299949-kmn53e2z 28 38 it -PRON- PRP cord-299949-kmn53e2z 28 39 difficult difficult JJ cord-299949-kmn53e2z 28 40 to to TO cord-299949-kmn53e2z 28 41 identify identify VB cord-299949-kmn53e2z 28 42 specific specific JJ cord-299949-kmn53e2z 28 43 effectors effector NNS cord-299949-kmn53e2z 28 44 that that WDT cord-299949-kmn53e2z 28 45 are be VBP cord-299949-kmn53e2z 28 46 crucial crucial JJ cord-299949-kmn53e2z 28 47 for for IN cord-299949-kmn53e2z 28 48 in in IN cord-299949-kmn53e2z 28 49 vivo vivo NN cord-299949-kmn53e2z 28 50 clearance clearance NN cord-299949-kmn53e2z 28 51 . . . cord-299949-kmn53e2z 29 1 Infection infection NN cord-299949-kmn53e2z 29 2 is be VBZ cord-299949-kmn53e2z 29 3 rarely rarely RB cord-299949-kmn53e2z 29 4 initiated initiate VBN cord-299949-kmn53e2z 29 5 in in IN cord-299949-kmn53e2z 29 6 the the DT cord-299949-kmn53e2z 29 7 CNS CNS NNP cord-299949-kmn53e2z 29 8 because because IN cord-299949-kmn53e2z 29 9 viruses virus NNS cord-299949-kmn53e2z 29 10 must must MD cord-299949-kmn53e2z 29 11 invade invade VB cord-299949-kmn53e2z 29 12 the the DT cord-299949-kmn53e2z 29 13 CNS CNS NNP cord-299949-kmn53e2z 29 14 from from IN cord-299949-kmn53e2z 29 15 initial initial JJ cord-299949-kmn53e2z 29 16 sites site NNS cord-299949-kmn53e2z 29 17 of of IN cord-299949-kmn53e2z 29 18 infection infection NN cord-299949-kmn53e2z 29 19 in in IN cord-299949-kmn53e2z 29 20 the the DT cord-299949-kmn53e2z 29 21 periphery periphery NN cord-299949-kmn53e2z 29 22 with with IN cord-299949-kmn53e2z 29 23 induction induction NN cord-299949-kmn53e2z 29 24 of of IN cord-299949-kmn53e2z 29 25 the the DT cord-299949-kmn53e2z 29 26 immune immune JJ cord-299949-kmn53e2z 29 27 response response NN cord-299949-kmn53e2z 29 28 in in IN cord-299949-kmn53e2z 29 29 peripheral peripheral JJ cord-299949-kmn53e2z 29 30 lymphoid lymphoid JJ cord-299949-kmn53e2z 29 31 tissues tissue NNS cord-299949-kmn53e2z 29 32 . . . cord-299949-kmn53e2z 30 1 Entry entry NN cord-299949-kmn53e2z 30 2 of of IN cord-299949-kmn53e2z 30 3 viruses virus NNS cord-299949-kmn53e2z 30 4 , , , cord-299949-kmn53e2z 30 5 immunoglobulins immunoglobulin NNS cord-299949-kmn53e2z 30 6 , , , cord-299949-kmn53e2z 30 7 and and CC cord-299949-kmn53e2z 30 8 immune immune JJ cord-299949-kmn53e2z 30 9 cells cell NNS cord-299949-kmn53e2z 30 10 from from IN cord-299949-kmn53e2z 30 11 the the DT cord-299949-kmn53e2z 30 12 blood blood NN cord-299949-kmn53e2z 30 13 is be VBZ cord-299949-kmn53e2z 30 14 restricted restrict VBN cord-299949-kmn53e2z 30 15 by by IN cord-299949-kmn53e2z 30 16 the the DT cord-299949-kmn53e2z 30 17 blood blood NN cord-299949-kmn53e2z 30 18 - - HYPH cord-299949-kmn53e2z 30 19 brain brain NN cord-299949-kmn53e2z 30 20 barrier barrier NN cord-299949-kmn53e2z 30 21 ( ( -LRB- cord-299949-kmn53e2z 30 22 BBB BBB NNP cord-299949-kmn53e2z 30 23 ) ) -RRB- cord-299949-kmn53e2z 30 24 , , , cord-299949-kmn53e2z 30 25 a a DT cord-299949-kmn53e2z 30 26 selectively selectively RB cord-299949-kmn53e2z 30 27 permeable permeable JJ cord-299949-kmn53e2z 30 28 barrier barrier NN cord-299949-kmn53e2z 30 29 with with IN cord-299949-kmn53e2z 30 30 tight tight JJ cord-299949-kmn53e2z 30 31 junctions junction NNS cord-299949-kmn53e2z 30 32 between between IN cord-299949-kmn53e2z 30 33 cerebrovascular cerebrovascular JJ cord-299949-kmn53e2z 30 34 endothelial endothelial JJ cord-299949-kmn53e2z 30 35 cells cell NNS cord-299949-kmn53e2z 30 36 that that WDT cord-299949-kmn53e2z 30 37 are be VBP cord-299949-kmn53e2z 30 38 supported support VBN cord-299949-kmn53e2z 30 39 by by IN cord-299949-kmn53e2z 30 40 astrocytes astrocyte NNS cord-299949-kmn53e2z 30 41 ( ( -LRB- cord-299949-kmn53e2z 30 42 Figure figure NN cord-299949-kmn53e2z 30 43 1 1 CD cord-299949-kmn53e2z 30 44 ) ) -RRB- cord-299949-kmn53e2z 30 45 . . . cord-299949-kmn53e2z 31 1 The the DT cord-299949-kmn53e2z 31 2 BBB BBB NNP cord-299949-kmn53e2z 31 3 separates separate VBZ cord-299949-kmn53e2z 31 4 the the DT cord-299949-kmn53e2z 31 5 parenchyma parenchyma NN cord-299949-kmn53e2z 31 6 of of IN cord-299949-kmn53e2z 31 7 the the DT cord-299949-kmn53e2z 31 8 CNS CNS NNP cord-299949-kmn53e2z 31 9 from from IN cord-299949-kmn53e2z 31 10 the the DT cord-299949-kmn53e2z 31 11 circulating circulate VBG cord-299949-kmn53e2z 31 12 blood blood NN cord-299949-kmn53e2z 31 13 and and CC cord-299949-kmn53e2z 31 14 serves serve VBZ cord-299949-kmn53e2z 31 15 as as IN cord-299949-kmn53e2z 31 16 a a DT cord-299949-kmn53e2z 31 17 physical physical JJ cord-299949-kmn53e2z 31 18 blockade blockade NN cord-299949-kmn53e2z 31 19 to to IN cord-299949-kmn53e2z 31 20 bloodborne bloodborne JJ cord-299949-kmn53e2z 31 21 infections infection NNS cord-299949-kmn53e2z 31 22 of of IN cord-299949-kmn53e2z 31 23 the the DT cord-299949-kmn53e2z 31 24 CNS CNS NNP cord-299949-kmn53e2z 31 25 . . . cord-299949-kmn53e2z 32 1 However however RB cord-299949-kmn53e2z 32 2 , , , cord-299949-kmn53e2z 32 3 the the DT cord-299949-kmn53e2z 32 4 endothelial endothelial JJ cord-299949-kmn53e2z 32 5 barrier barrier NN cord-299949-kmn53e2z 32 6 is be VBZ cord-299949-kmn53e2z 32 7 more more RBR cord-299949-kmn53e2z 32 8 permeable permeable JJ cord-299949-kmn53e2z 32 9 at at IN cord-299949-kmn53e2z 32 10 certain certain JJ cord-299949-kmn53e2z 32 11 sites site NNS cord-299949-kmn53e2z 32 12 in in IN cord-299949-kmn53e2z 32 13 the the DT cord-299949-kmn53e2z 32 14 CNS CNS NNP cord-299949-kmn53e2z 32 15 ( ( -LRB- cord-299949-kmn53e2z 32 16 e.g. e.g. RB cord-299949-kmn53e2z 32 17 , , , cord-299949-kmn53e2z 32 18 choroid choroid NN cord-299949-kmn53e2z 32 19 plexus plexus NN cord-299949-kmn53e2z 32 20 ) ) -RRB- cord-299949-kmn53e2z 32 21 and and CC cord-299949-kmn53e2z 32 22 inflammation inflammation NN cord-299949-kmn53e2z 32 23 increases increase VBZ cord-299949-kmn53e2z 32 24 permeability permeability NN cord-299949-kmn53e2z 32 25 to to TO cord-299949-kmn53e2z 32 26 allow allow VB cord-299949-kmn53e2z 32 27 immune immune JJ cord-299949-kmn53e2z 32 28 cell cell NN cord-299949-kmn53e2z 32 29 infiltration infiltration NN cord-299949-kmn53e2z 32 30 along along IN cord-299949-kmn53e2z 32 31 with with IN cord-299949-kmn53e2z 32 32 opportunities opportunity NNS cord-299949-kmn53e2z 32 33 for for IN cord-299949-kmn53e2z 32 34 virus virus NN cord-299949-kmn53e2z 32 35 entry entry NN cord-299949-kmn53e2z 32 36 . . . cord-299949-kmn53e2z 33 1 Historically historically RB cord-299949-kmn53e2z 33 2 , , , cord-299949-kmn53e2z 33 3 routes route NNS cord-299949-kmn53e2z 33 4 of of IN cord-299949-kmn53e2z 33 5 CNS CNS NNP cord-299949-kmn53e2z 33 6 infection infection NN cord-299949-kmn53e2z 33 7 have have VBP cord-299949-kmn53e2z 33 8 been be VBN cord-299949-kmn53e2z 33 9 deduced deduce VBN cord-299949-kmn53e2z 33 10 from from IN cord-299949-kmn53e2z 33 11 data datum NNS cord-299949-kmn53e2z 33 12 obtained obtain VBN cord-299949-kmn53e2z 33 13 by by IN cord-299949-kmn53e2z 33 14 histological histological JJ cord-299949-kmn53e2z 33 15 staining staining NN cord-299949-kmn53e2z 33 16 at at IN cord-299949-kmn53e2z 33 17 early early JJ cord-299949-kmn53e2z 33 18 times time NNS cord-299949-kmn53e2z 33 19 after after IN cord-299949-kmn53e2z 33 20 infection infection NN cord-299949-kmn53e2z 33 21 or or CC cord-299949-kmn53e2z 33 22 disruption disruption NN cord-299949-kmn53e2z 33 23 of of IN cord-299949-kmn53e2z 33 24 a a DT cord-299949-kmn53e2z 33 25 potential potential JJ cord-299949-kmn53e2z 33 26 route route NN cord-299949-kmn53e2z 33 27 of of IN cord-299949-kmn53e2z 33 28 infection infection NN cord-299949-kmn53e2z 33 29 . . . cord-299949-kmn53e2z 34 1 Entry entry NN cord-299949-kmn53e2z 34 2 routes route NNS cord-299949-kmn53e2z 34 3 are be VBP cord-299949-kmn53e2z 34 4 not not RB cord-299949-kmn53e2z 34 5 mutually mutually RB cord-299949-kmn53e2z 34 6 exclusive exclusive JJ cord-299949-kmn53e2z 34 7 , , , cord-299949-kmn53e2z 34 8 as as IN cord-299949-kmn53e2z 34 9 multiple multiple JJ cord-299949-kmn53e2z 34 10 routes route NNS cord-299949-kmn53e2z 34 11 have have VBP cord-299949-kmn53e2z 34 12 been be VBN cord-299949-kmn53e2z 34 13 described describe VBN cord-299949-kmn53e2z 34 14 for for IN cord-299949-kmn53e2z 34 15 some some DT cord-299949-kmn53e2z 34 16 viruses virus NNS cord-299949-kmn53e2z 34 17 . . . cord-299949-kmn53e2z 35 1 Recently recently RB cord-299949-kmn53e2z 35 2 , , , cord-299949-kmn53e2z 35 3 new new JJ cord-299949-kmn53e2z 35 4 techniques technique NNS cord-299949-kmn53e2z 35 5 such such JJ cord-299949-kmn53e2z 35 6 as as IN cord-299949-kmn53e2z 35 7 intravital intravital JJ cord-299949-kmn53e2z 35 8 microscopy microscopy NNS cord-299949-kmn53e2z 35 9 and and CC cord-299949-kmn53e2z 35 10 CLARITY clarity NN cord-299949-kmn53e2z 35 11 preparation preparation NN cord-299949-kmn53e2z 35 12 of of IN cord-299949-kmn53e2z 35 13 infected infected JJ cord-299949-kmn53e2z 35 14 brains brain NNS cord-299949-kmn53e2z 35 15 have have VBP cord-299949-kmn53e2z 35 16 been be VBN cord-299949-kmn53e2z 35 17 developed develop VBN cord-299949-kmn53e2z 35 18 that that WDT cord-299949-kmn53e2z 35 19 may may MD cord-299949-kmn53e2z 35 20 lead lead VB cord-299949-kmn53e2z 35 21 to to IN cord-299949-kmn53e2z 35 22 new new JJ cord-299949-kmn53e2z 35 23 insights insight NNS cord-299949-kmn53e2z 35 24 on on IN cord-299949-kmn53e2z 35 25 the the DT cord-299949-kmn53e2z 35 26 mechanisms mechanism NNS cord-299949-kmn53e2z 35 27 of of IN cord-299949-kmn53e2z 35 28 CNS CNS NNP cord-299949-kmn53e2z 35 29 entry entry NN cord-299949-kmn53e2z 36 1 ( ( -LRB- cord-299949-kmn53e2z 36 2 Yang Yang NNP cord-299949-kmn53e2z 36 3 et et NNP cord-299949-kmn53e2z 36 4 al al NNP cord-299949-kmn53e2z 36 5 . . NNP cord-299949-kmn53e2z 36 6 , , , cord-299949-kmn53e2z 36 7 2014 2014 CD cord-299949-kmn53e2z 36 8 ; ; . cord-299949-kmn53e2z 37 1 Chung Chung NNP cord-299949-kmn53e2z 37 2 et et NNP cord-299949-kmn53e2z 37 3 al al NNP cord-299949-kmn53e2z 37 4 . . NNP cord-299949-kmn53e2z 37 5 , , , cord-299949-kmn53e2z 37 6 2013 2013 CD cord-299949-kmn53e2z 37 7 ; ; : cord-299949-kmn53e2z 38 1 McGavern McGavern NNP cord-299949-kmn53e2z 38 2 and and CC cord-299949-kmn53e2z 38 3 Kang Kang NNP cord-299949-kmn53e2z 38 4 , , , cord-299949-kmn53e2z 38 5 2011 2011 CD cord-299949-kmn53e2z 38 6 ) ) -RRB- cord-299949-kmn53e2z 38 7 . . . cord-299949-kmn53e2z 39 1 In in IN cord-299949-kmn53e2z 39 2 general general JJ cord-299949-kmn53e2z 39 3 , , , cord-299949-kmn53e2z 39 4 virus virus NN cord-299949-kmn53e2z 39 5 entry entry NN cord-299949-kmn53e2z 39 6 is be VBZ cord-299949-kmn53e2z 39 7 either either CC cord-299949-kmn53e2z 39 8 from from IN cord-299949-kmn53e2z 39 9 the the DT cord-299949-kmn53e2z 39 10 periphery periphery NN cord-299949-kmn53e2z 39 11 by by IN cord-299949-kmn53e2z 39 12 neuronal neuronal JJ cord-299949-kmn53e2z 39 13 axonal axonal JJ cord-299949-kmn53e2z 39 14 transport transport NN cord-299949-kmn53e2z 39 15 or or CC cord-299949-kmn53e2z 39 16 from from IN cord-299949-kmn53e2z 39 17 the the DT cord-299949-kmn53e2z 39 18 bloodstream bloodstream NN cord-299949-kmn53e2z 39 19 across across IN cord-299949-kmn53e2z 39 20 the the DT cord-299949-kmn53e2z 39 21 vascular vascular JJ cord-299949-kmn53e2z 39 22 endothelium endothelium NN cord-299949-kmn53e2z 39 23 . . . cord-299949-kmn53e2z 40 1 Sensory sensory JJ cord-299949-kmn53e2z 40 2 and and CC cord-299949-kmn53e2z 40 3 motor motor NN cord-299949-kmn53e2z 40 4 neurons neuron NNS cord-299949-kmn53e2z 40 5 extend extend VBP cord-299949-kmn53e2z 40 6 their -PRON- PRP$ cord-299949-kmn53e2z 40 7 processes process NNS cord-299949-kmn53e2z 40 8 into into IN cord-299949-kmn53e2z 40 9 the the DT cord-299949-kmn53e2z 40 10 periphery periphery NN cord-299949-kmn53e2z 40 11 and and CC cord-299949-kmn53e2z 40 12 provide provide VB cord-299949-kmn53e2z 40 13 a a DT cord-299949-kmn53e2z 40 14 point point NN cord-299949-kmn53e2z 40 15 of of IN cord-299949-kmn53e2z 40 16 entry entry NN cord-299949-kmn53e2z 40 17 for for IN cord-299949-kmn53e2z 40 18 some some DT cord-299949-kmn53e2z 40 19 neurotropic neurotropic NNS cord-299949-kmn53e2z 40 20 viruses virus NNS cord-299949-kmn53e2z 40 21 replicating replicate VBG cord-299949-kmn53e2z 40 22 in in IN cord-299949-kmn53e2z 40 23 peripheral peripheral JJ cord-299949-kmn53e2z 40 24 tissue tissue NN cord-299949-kmn53e2z 40 25 . . . cord-299949-kmn53e2z 41 1 Expression expression NN cord-299949-kmn53e2z 41 2 of of IN cord-299949-kmn53e2z 41 3 viral viral JJ cord-299949-kmn53e2z 41 4 receptors receptor NNS cord-299949-kmn53e2z 41 5 on on IN cord-299949-kmn53e2z 41 6 neuromuscular neuromuscular JJ cord-299949-kmn53e2z 41 7 junctions junction NNS cord-299949-kmn53e2z 41 8 facilitates facilitate VBZ cord-299949-kmn53e2z 41 9 entry entry NN cord-299949-kmn53e2z 41 10 of of IN cord-299949-kmn53e2z 41 11 poliovirus poliovirus NN cord-299949-kmn53e2z 41 12 , , , cord-299949-kmn53e2z 41 13 adenovirus adenovirus NN cord-299949-kmn53e2z 41 14 , , , cord-299949-kmn53e2z 41 15 and and CC cord-299949-kmn53e2z 41 16 rabies rabies NN cord-299949-kmn53e2z 41 17 virus virus NN cord-299949-kmn53e2z 41 18 into into IN cord-299949-kmn53e2z 41 19 the the DT cord-299949-kmn53e2z 41 20 CNS CNS NNP cord-299949-kmn53e2z 41 21 ( ( -LRB- cord-299949-kmn53e2z 41 22 Salinas Salinas NNP cord-299949-kmn53e2z 41 23 et et NNP cord-299949-kmn53e2z 41 24 al al NNP cord-299949-kmn53e2z 41 25 . . NNP cord-299949-kmn53e2z 41 26 , , , cord-299949-kmn53e2z 41 27 2010 2010 CD cord-299949-kmn53e2z 41 28 ) ) -RRB- cord-299949-kmn53e2z 41 29 . . . cord-299949-kmn53e2z 42 1 Olfactory olfactory JJ cord-299949-kmn53e2z 42 2 neurons neuron NNS cord-299949-kmn53e2z 42 3 that that WDT cord-299949-kmn53e2z 42 4 project project VBP cord-299949-kmn53e2z 42 5 into into IN cord-299949-kmn53e2z 42 6 the the DT cord-299949-kmn53e2z 42 7 respiratory respiratory JJ cord-299949-kmn53e2z 42 8 mucosal mucosal JJ cord-299949-kmn53e2z 42 9 epithelium epithelium NN cord-299949-kmn53e2z 42 10 can can MD cord-299949-kmn53e2z 42 11 provide provide VB cord-299949-kmn53e2z 42 12 a a DT cord-299949-kmn53e2z 42 13 direct direct JJ cord-299949-kmn53e2z 42 14 route route NN cord-299949-kmn53e2z 42 15 to to IN cord-299949-kmn53e2z 42 16 the the DT cord-299949-kmn53e2z 42 17 brain brain NN cord-299949-kmn53e2z 42 18 for for IN cord-299949-kmn53e2z 42 19 alphaviruses alphaviruses NNP cord-299949-kmn53e2z 43 1 ( ( -LRB- cord-299949-kmn53e2z 43 2 Phillips Phillips NNP cord-299949-kmn53e2z 43 3 et et NNP cord-299949-kmn53e2z 43 4 al al NNP cord-299949-kmn53e2z 43 5 . . NNP cord-299949-kmn53e2z 43 6 , , , cord-299949-kmn53e2z 43 7 2013 2013 CD cord-299949-kmn53e2z 43 8 ; ; : cord-299949-kmn53e2z 43 9 Powers Powers NNPS cord-299949-kmn53e2z 43 10 and and CC cord-299949-kmn53e2z 43 11 Logue Logue NNP cord-299949-kmn53e2z 43 12 , , , cord-299949-kmn53e2z 43 13 2007 2007 CD cord-299949-kmn53e2z 43 14 ; ; : cord-299949-kmn53e2z 43 15 Charles Charles NNP cord-299949-kmn53e2z 43 16 et et NNP cord-299949-kmn53e2z 43 17 al al NNP cord-299949-kmn53e2z 43 18 . . NNP cord-299949-kmn53e2z 43 19 , , , cord-299949-kmn53e2z 43 20 1995 1995 CD cord-299949-kmn53e2z 43 21 ) ) -RRB- cord-299949-kmn53e2z 43 22 , , , cord-299949-kmn53e2z 43 23 flaviviruses flaviviruses NNP cord-299949-kmn53e2z 43 24 ( ( -LRB- cord-299949-kmn53e2z 43 25 Yamada Yamada NNP cord-299949-kmn53e2z 43 26 et et FW cord-299949-kmn53e2z 43 27 al al NNP cord-299949-kmn53e2z 43 28 . . NNP cord-299949-kmn53e2z 43 29 , , , cord-299949-kmn53e2z 43 30 2009 2009 CD cord-299949-kmn53e2z 43 31 ; ; . cord-299949-kmn53e2z 44 1 Monath Monath NNP cord-299949-kmn53e2z 44 2 et et NNP cord-299949-kmn53e2z 44 3 al al NNP cord-299949-kmn53e2z 44 4 . . NNP cord-299949-kmn53e2z 44 5 , , , cord-299949-kmn53e2z 44 6 1983 1983 CD cord-299949-kmn53e2z 44 7 ) ) -RRB- cord-299949-kmn53e2z 44 8 , , , cord-299949-kmn53e2z 44 9 coronaviruses coronaviruses NNP cord-299949-kmn53e2z 44 10 ( ( -LRB- cord-299949-kmn53e2z 44 11 Barnett Barnett NNP cord-299949-kmn53e2z 44 12 and and CC cord-299949-kmn53e2z 44 13 Perlman Perlman NNP cord-299949-kmn53e2z 44 14 , , , cord-299949-kmn53e2z 44 15 1993 1993 CD cord-299949-kmn53e2z 44 16 ) ) -RRB- cord-299949-kmn53e2z 44 17 , , , cord-299949-kmn53e2z 44 18 paramyxoviruses paramyxoviruses NNP cord-299949-kmn53e2z 44 19 ( ( -LRB- cord-299949-kmn53e2z 44 20 Munster Munster NNP cord-299949-kmn53e2z 44 21 et et NNP cord-299949-kmn53e2z 44 22 al al NNP cord-299949-kmn53e2z 44 23 . . NNP cord-299949-kmn53e2z 44 24 , , , cord-299949-kmn53e2z 44 25 2012 2012 CD cord-299949-kmn53e2z 44 26 ) ) -RRB- cord-299949-kmn53e2z 44 27 , , , cord-299949-kmn53e2z 44 28 bunyaviruses bunyaviruses NNP cord-299949-kmn53e2z 44 29 ( ( -LRB- cord-299949-kmn53e2z 44 30 Bennett Bennett NNP cord-299949-kmn53e2z 44 31 et et NNP cord-299949-kmn53e2z 44 32 al al NNP cord-299949-kmn53e2z 44 33 . . NNP cord-299949-kmn53e2z 44 34 , , , cord-299949-kmn53e2z 44 35 2008 2008 CD cord-299949-kmn53e2z 44 36 ) ) -RRB- cord-299949-kmn53e2z 44 37 , , , cord-299949-kmn53e2z 44 38 and and CC cord-299949-kmn53e2z 44 39 occasionally occasionally RB cord-299949-kmn53e2z 44 40 influenza influenza JJ cord-299949-kmn53e2z 44 41 virus virus NN cord-299949-kmn53e2z 44 42 ( ( -LRB- cord-299949-kmn53e2z 44 43 van van NNP cord-299949-kmn53e2z 44 44 Riel Riel NNP cord-299949-kmn53e2z 44 45 et et FW cord-299949-kmn53e2z 44 46 al al NNP cord-299949-kmn53e2z 44 47 . . NNP cord-299949-kmn53e2z 44 48 , , , cord-299949-kmn53e2z 44 49 2014 2014 CD cord-299949-kmn53e2z 44 50 ) ) -RRB- cord-299949-kmn53e2z 44 51 . . . cord-299949-kmn53e2z 45 1 Hematogenous hematogenous JJ cord-299949-kmn53e2z 45 2 entry entry NN cord-299949-kmn53e2z 45 3 occurs occur VBZ cord-299949-kmn53e2z 45 4 when when WRB cord-299949-kmn53e2z 45 5 a a DT cord-299949-kmn53e2z 45 6 virus virus NN cord-299949-kmn53e2z 45 7 directly directly RB cord-299949-kmn53e2z 45 8 infects infect VBZ cord-299949-kmn53e2z 45 9 BBB BBB NNP cord-299949-kmn53e2z 45 10 endothelial endothelial JJ cord-299949-kmn53e2z 45 11 cells cell NNS cord-299949-kmn53e2z 45 12 or or CC cord-299949-kmn53e2z 45 13 infects infect VBZ cord-299949-kmn53e2z 45 14 leukocytes leukocyte NNS cord-299949-kmn53e2z 45 15 that that WDT cord-299949-kmn53e2z 45 16 cross cross VBP cord-299949-kmn53e2z 45 17 the the DT cord-299949-kmn53e2z 45 18 BBB BBB NNP cord-299949-kmn53e2z 45 19 providing provide VBG cord-299949-kmn53e2z 45 20 entry entry NN cord-299949-kmn53e2z 45 21 by by IN cord-299949-kmn53e2z 45 22 a a DT cord-299949-kmn53e2z 45 23 ' ' `` cord-299949-kmn53e2z 45 24 Trojan Trojan NNP cord-299949-kmn53e2z 45 25 horse horse NN cord-299949-kmn53e2z 45 26 ' ' '' cord-299949-kmn53e2z 45 27 mechanism mechanism NN cord-299949-kmn53e2z 45 28 ( ( -LRB- cord-299949-kmn53e2z 45 29 Neal Neal NNP cord-299949-kmn53e2z 45 30 , , , cord-299949-kmn53e2z 45 31 2014 2014 CD cord-299949-kmn53e2z 45 32 ; ; : cord-299949-kmn53e2z 45 33 Wilson Wilson NNP cord-299949-kmn53e2z 45 34 , , , cord-299949-kmn53e2z 45 35 2013 2013 CD cord-299949-kmn53e2z 45 36 ; ; : cord-299949-kmn53e2z 45 37 Rhoades Rhoades NNP cord-299949-kmn53e2z 45 38 et et NNP cord-299949-kmn53e2z 45 39 al al NNP cord-299949-kmn53e2z 45 40 . . NNP cord-299949-kmn53e2z 45 41 , , , cord-299949-kmn53e2z 45 42 2011 2011 CD cord-299949-kmn53e2z 45 43 ; ; : cord-299949-kmn53e2z 45 44 Kim Kim NNP cord-299949-kmn53e2z 45 45 , , , cord-299949-kmn53e2z 45 46 2003 2003 CD cord-299949-kmn53e2z 45 47 ; ; : cord-299949-kmn53e2z 45 48 Haase Haase NNP cord-299949-kmn53e2z 45 49 , , , cord-299949-kmn53e2z 45 50 1986 1986 CD cord-299949-kmn53e2z 45 51 ) ) -RRB- cord-299949-kmn53e2z 45 52 . . . cord-299949-kmn53e2z 46 1 The the DT cord-299949-kmn53e2z 46 2 CNS CNS NNP cord-299949-kmn53e2z 46 3 is be VBZ cord-299949-kmn53e2z 46 4 relatively relatively RB cord-299949-kmn53e2z 46 5 protected protect VBN cord-299949-kmn53e2z 46 6 from from IN cord-299949-kmn53e2z 46 7 immunologic immunologic JJ cord-299949-kmn53e2z 46 8 activity activity NN cord-299949-kmn53e2z 46 9 . . . cord-299949-kmn53e2z 47 1 In in IN cord-299949-kmn53e2z 47 2 addition addition NN cord-299949-kmn53e2z 47 3 to to IN cord-299949-kmn53e2z 47 4 the the DT cord-299949-kmn53e2z 47 5 physical physical JJ cord-299949-kmn53e2z 47 6 protection protection NN cord-299949-kmn53e2z 47 7 by by IN cord-299949-kmn53e2z 47 8 the the DT cord-299949-kmn53e2z 47 9 BBB BBB NNP cord-299949-kmn53e2z 47 10 , , , cord-299949-kmn53e2z 47 11 the the DT cord-299949-kmn53e2z 47 12 brain brain NN cord-299949-kmn53e2z 47 13 parenchyma parenchyma NN cord-299949-kmn53e2z 47 14 has have VBZ cord-299949-kmn53e2z 47 15 no no DT cord-299949-kmn53e2z 47 16 lymphatic lymphatic JJ cord-299949-kmn53e2z 47 17 vessels vessel NNS cord-299949-kmn53e2z 47 18 or or CC cord-299949-kmn53e2z 47 19 professional professional JJ cord-299949-kmn53e2z 47 20 antigenpresenting antigenpresenting NN cord-299949-kmn53e2z 47 21 cells cell NNS cord-299949-kmn53e2z 47 22 , , , cord-299949-kmn53e2z 47 23 low low JJ cord-299949-kmn53e2z 47 24 expression expression NN cord-299949-kmn53e2z 47 25 of of IN cord-299949-kmn53e2z 47 26 major major JJ cord-299949-kmn53e2z 47 27 histocompatibility histocompatibility NN cord-299949-kmn53e2z 47 28 complex complex NN cord-299949-kmn53e2z 47 29 ( ( -LRB- cord-299949-kmn53e2z 47 30 MHC MHC NNP cord-299949-kmn53e2z 47 31 ) ) -RRB- cord-299949-kmn53e2z 47 32 molecules molecule NNS cord-299949-kmn53e2z 47 33 , , , cord-299949-kmn53e2z 47 34 and and CC cord-299949-kmn53e2z 47 35 active active JJ cord-299949-kmn53e2z 47 36 maintenance maintenance NN cord-299949-kmn53e2z 47 37 of of IN cord-299949-kmn53e2z 47 38 an an DT cord-299949-kmn53e2z 47 39 immunologically immunologically RB cord-299949-kmn53e2z 47 40 quiescent quiescent JJ cord-299949-kmn53e2z 47 41 state state NN cord-299949-kmn53e2z 47 42 . . . cord-299949-kmn53e2z 48 1 However however RB cord-299949-kmn53e2z 48 2 , , , cord-299949-kmn53e2z 48 3 the the DT cord-299949-kmn53e2z 48 4 exclusion exclusion NN cord-299949-kmn53e2z 48 5 of of IN cord-299949-kmn53e2z 48 6 immune immune JJ cord-299949-kmn53e2z 48 7 cells cell NNS cord-299949-kmn53e2z 48 8 and and CC cord-299949-kmn53e2z 48 9 the the DT cord-299949-kmn53e2z 48 10 role role NN cord-299949-kmn53e2z 48 11 of of IN cord-299949-kmn53e2z 48 12 active active JJ cord-299949-kmn53e2z 48 13 immune immune NN cord-299949-kmn53e2z 48 14 signaling signaling NN cord-299949-kmn53e2z 48 15 in in IN cord-299949-kmn53e2z 48 16 the the DT cord-299949-kmn53e2z 48 17 CNS CNS NNP cord-299949-kmn53e2z 48 18 has have VBZ cord-299949-kmn53e2z 48 19 been be VBN cord-299949-kmn53e2z 48 20 redefined redefine VBN cord-299949-kmn53e2z 48 21 recently recently RB cord-299949-kmn53e2z 49 1 ( ( -LRB- cord-299949-kmn53e2z 49 2 Schwartz Schwartz NNP cord-299949-kmn53e2z 49 3 et et NNP cord-299949-kmn53e2z 49 4 al al NNP cord-299949-kmn53e2z 49 5 . . NNP cord-299949-kmn53e2z 49 6 , , , cord-299949-kmn53e2z 49 7 2013 2013 CD cord-299949-kmn53e2z 49 8 ; ; : cord-299949-kmn53e2z 49 9 Muldoon Muldoon NNP cord-299949-kmn53e2z 49 10 et et NNP cord-299949-kmn53e2z 49 11 al al NNP cord-299949-kmn53e2z 49 12 . . NNP cord-299949-kmn53e2z 49 13 , , , cord-299949-kmn53e2z 49 14 2013 2013 CD cord-299949-kmn53e2z 49 15 ; ; : cord-299949-kmn53e2z 49 16 Elmer Elmer NNP cord-299949-kmn53e2z 49 17 and and CC cord-299949-kmn53e2z 49 18 McAllister McAllister NNP cord-299949-kmn53e2z 49 19 , , , cord-299949-kmn53e2z 49 20 2012 2012 CD cord-299949-kmn53e2z 49 21 ; ; : cord-299949-kmn53e2z 49 22 Hernangómez Hernangómez NNP cord-299949-kmn53e2z 49 23 et et NNP cord-299949-kmn53e2z 49 24 al al NNP cord-299949-kmn53e2z 49 25 . . NNP cord-299949-kmn53e2z 49 26 , , , cord-299949-kmn53e2z 49 27 2012 2012 CD cord-299949-kmn53e2z 49 28 ) ) -RRB- cord-299949-kmn53e2z 49 29 . . . cord-299949-kmn53e2z 50 1 Resident resident JJ cord-299949-kmn53e2z 50 2 cells cell NNS cord-299949-kmn53e2z 50 3 in in IN cord-299949-kmn53e2z 50 4 the the DT cord-299949-kmn53e2z 50 5 nervous nervous JJ cord-299949-kmn53e2z 50 6 system system NN cord-299949-kmn53e2z 50 7 , , , cord-299949-kmn53e2z 50 8 including include VBG cord-299949-kmn53e2z 50 9 neurons neuron NNS cord-299949-kmn53e2z 50 10 , , , cord-299949-kmn53e2z 50 11 play play VB cord-299949-kmn53e2z 50 12 an an DT cord-299949-kmn53e2z 50 13 active active JJ cord-299949-kmn53e2z 50 14 role role NN cord-299949-kmn53e2z 50 15 in in IN cord-299949-kmn53e2z 50 16 the the DT cord-299949-kmn53e2z 50 17 immune immune JJ cord-299949-kmn53e2z 50 18 response response NN cord-299949-kmn53e2z 50 19 ( ( -LRB- cord-299949-kmn53e2z 50 20 Schultz Schultz NNP cord-299949-kmn53e2z 50 21 et et NNP cord-299949-kmn53e2z 50 22 al al NNP cord-299949-kmn53e2z 50 23 . . NNP cord-299949-kmn53e2z 50 24 , , , cord-299949-kmn53e2z 50 25 2014 2014 CD cord-299949-kmn53e2z 50 26 ; ; : cord-299949-kmn53e2z 50 27 O'Donnell O'Donnell NNP cord-299949-kmn53e2z 50 28 et et NNP cord-299949-kmn53e2z 50 29 al al NNP cord-299949-kmn53e2z 50 30 . . NNP cord-299949-kmn53e2z 50 31 , , , cord-299949-kmn53e2z 50 32 2012 2012 CD cord-299949-kmn53e2z 50 33 ; ; : cord-299949-kmn53e2z 50 34 Chakraborty Chakraborty NNP cord-299949-kmn53e2z 50 35 et et NNP cord-299949-kmn53e2z 50 36 al al NNP cord-299949-kmn53e2z 50 37 . . NNP cord-299949-kmn53e2z 50 38 , , , cord-299949-kmn53e2z 50 39 2010 2010 CD cord-299949-kmn53e2z 50 40 ; ; . cord-299949-kmn53e2z 51 1 Daffis Daffis NNP cord-299949-kmn53e2z 51 2 et et NNP cord-299949-kmn53e2z 51 3 al al NNP cord-299949-kmn53e2z 51 4 . . . cord-299949-kmn53e2z 52 1 , , , cord-299949-kmn53e2z 52 2 2008a 2008a CD cord-299949-kmn53e2z 52 3 ; ; : cord-299949-kmn53e2z 52 4 Castorena Castorena NNP cord-299949-kmn53e2z 52 5 et et FW cord-299949-kmn53e2z 52 6 al al NNP cord-299949-kmn53e2z 52 7 . . NNP cord-299949-kmn53e2z 52 8 , , , cord-299949-kmn53e2z 52 9 2008 2008 CD cord-299949-kmn53e2z 53 1 ; ; : cord-299949-kmn53e2z 53 2 Daffis Daffis NNP cord-299949-kmn53e2z 53 3 et et NNP cord-299949-kmn53e2z 53 4 al al NNP cord-299949-kmn53e2z 53 5 . . NNP cord-299949-kmn53e2z 53 6 , , , cord-299949-kmn53e2z 53 7 2007 2007 CD cord-299949-kmn53e2z 53 8 ; ; : cord-299949-kmn53e2z 53 9 _SP cord-299949-kmn53e2z 53 10 Commonly commonly RB cord-299949-kmn53e2z 53 11 used use VBN cord-299949-kmn53e2z 53 12 in in IN cord-299949-kmn53e2z 53 13 mouse mouse NN cord-299949-kmn53e2z 53 14 models model NNS cord-299949-kmn53e2z 53 15 of of IN cord-299949-kmn53e2z 53 16 viral viral JJ cord-299949-kmn53e2z 53 17 encephalitis encephalitis RB cord-299949-kmn53e2z 53 18 . . . cord-299949-kmn53e2z 54 1 Jackson Jackson NNP cord-299949-kmn53e2z 54 2 et et NNP cord-299949-kmn53e2z 54 3 al al NNP cord-299949-kmn53e2z 54 4 . . NNP cord-299949-kmn53e2z 54 5 , , , cord-299949-kmn53e2z 54 6 2006 2006 CD cord-299949-kmn53e2z 54 7 ) ) -RRB- cord-299949-kmn53e2z 54 8 . . . cord-299949-kmn53e2z 55 1 Additionally additionally RB cord-299949-kmn53e2z 55 2 , , , cord-299949-kmn53e2z 55 3 memory memory NN cord-299949-kmn53e2z 55 4 T t NN cord-299949-kmn53e2z 55 5 cell cell NN cord-299949-kmn53e2z 55 6 and and CC cord-299949-kmn53e2z 55 7 B b NN cord-299949-kmn53e2z 55 8 cell cell NN cord-299949-kmn53e2z 55 9 are be VBP cord-299949-kmn53e2z 55 10 found find VBN cord-299949-kmn53e2z 55 11 in in IN cord-299949-kmn53e2z 55 12 the the DT cord-299949-kmn53e2z 55 13 CNS CNS NNP cord-299949-kmn53e2z 55 14 long long RB cord-299949-kmn53e2z 55 15 after after IN cord-299949-kmn53e2z 55 16 infectious infectious JJ cord-299949-kmn53e2z 55 17 virus virus NN cord-299949-kmn53e2z 55 18 has have VBZ cord-299949-kmn53e2z 55 19 been be VBN cord-299949-kmn53e2z 55 20 eliminated eliminate VBN cord-299949-kmn53e2z 56 1 ( ( -LRB- cord-299949-kmn53e2z 56 2 Phares Phares NNP cord-299949-kmn53e2z 56 3 et et NNP cord-299949-kmn53e2z 56 4 al al NNP cord-299949-kmn53e2z 56 5 . . NNP cord-299949-kmn53e2z 56 6 , , , cord-299949-kmn53e2z 56 7 2013 2013 CD cord-299949-kmn53e2z 56 8 ; ; : cord-299949-kmn53e2z 56 9 Metcalf Metcalf NNP cord-299949-kmn53e2z 56 10 et et NNP cord-299949-kmn53e2z 56 11 al al NNP cord-299949-kmn53e2z 56 12 . . NNP cord-299949-kmn53e2z 56 13 , , , cord-299949-kmn53e2z 56 14 2013 2013 CD cord-299949-kmn53e2z 56 15 ; ; : cord-299949-kmn53e2z 56 16 Wakim Wakim NNP cord-299949-kmn53e2z 56 17 et et NNP cord-299949-kmn53e2z 56 18 al al NNP cord-299949-kmn53e2z 56 19 . . NNP cord-299949-kmn53e2z 56 20 , , , cord-299949-kmn53e2z 56 21 2010 2010 CD cord-299949-kmn53e2z 56 22 ; ; . cord-299949-kmn53e2z 57 1 Wilson Wilson NNP cord-299949-kmn53e2z 57 2 et et NNP cord-299949-kmn53e2z 57 3 al al NNP cord-299949-kmn53e2z 57 4 . . NNP cord-299949-kmn53e2z 57 5 , , , cord-299949-kmn53e2z 57 6 2010 2010 CD cord-299949-kmn53e2z 57 7 ) ) -RRB- cord-299949-kmn53e2z 57 8 . . . cord-299949-kmn53e2z 58 1 Resident resident JJ cord-299949-kmn53e2z 58 2 cells cell NNS cord-299949-kmn53e2z 58 3 monitor monitor VBP cord-299949-kmn53e2z 58 4 the the DT cord-299949-kmn53e2z 58 5 CNS CNS NNP cord-299949-kmn53e2z 58 6 for for IN cord-299949-kmn53e2z 58 7 infection infection NN cord-299949-kmn53e2z 58 8 and and CC cord-299949-kmn53e2z 58 9 initiate initiate VB cord-299949-kmn53e2z 58 10 and and CC cord-299949-kmn53e2z 58 11 control control VB cord-299949-kmn53e2z 58 12 inflammation inflammation NN cord-299949-kmn53e2z 58 13 when when WRB cord-299949-kmn53e2z 58 14 infection infection NN cord-299949-kmn53e2z 58 15 occurs occur VBZ cord-299949-kmn53e2z 58 16 . . . cord-299949-kmn53e2z 59 1 Microglial microglial JJ cord-299949-kmn53e2z 59 2 cells cell NNS cord-299949-kmn53e2z 59 3 , , , cord-299949-kmn53e2z 59 4 the the DT cord-299949-kmn53e2z 59 5 resident resident JJ cord-299949-kmn53e2z 59 6 macrophages macrophage NNS cord-299949-kmn53e2z 59 7 of of IN cord-299949-kmn53e2z 59 8 the the DT cord-299949-kmn53e2z 59 9 CNS CNS NNP cord-299949-kmn53e2z 59 10 , , , cord-299949-kmn53e2z 59 11 express express VB cord-299949-kmn53e2z 59 12 the the DT cord-299949-kmn53e2z 59 13 CD200 CD200 NNP cord-299949-kmn53e2z 59 14 receptor receptor NN cord-299949-kmn53e2z 59 15 ( ( -LRB- cord-299949-kmn53e2z 59 16 CD200R CD200R NNP cord-299949-kmn53e2z 59 17 ) ) -RRB- cord-299949-kmn53e2z 59 18 , , , cord-299949-kmn53e2z 59 19 TREM2 TREM2 NNP cord-299949-kmn53e2z 59 20 , , , cord-299949-kmn53e2z 59 21 CD172a CD172a NNP cord-299949-kmn53e2z 59 22 , , , cord-299949-kmn53e2z 59 23 and and CC cord-299949-kmn53e2z 59 24 CD45 CD45 NNP cord-299949-kmn53e2z 59 25 and and CC cord-299949-kmn53e2z 59 26 are be VBP cord-299949-kmn53e2z 59 27 kept keep VBN cord-299949-kmn53e2z 59 28 in in IN cord-299949-kmn53e2z 59 29 a a DT cord-299949-kmn53e2z 59 30 quiescent quiescent JJ cord-299949-kmn53e2z 59 31 state state NN cord-299949-kmn53e2z 59 32 through through IN cord-299949-kmn53e2z 59 33 interactions interaction NNS cord-299949-kmn53e2z 59 34 with with IN cord-299949-kmn53e2z 59 35 electrically electrically RB cord-299949-kmn53e2z 59 36 active active JJ cord-299949-kmn53e2z 59 37 , , , cord-299949-kmn53e2z 59 38 healthy healthy JJ cord-299949-kmn53e2z 59 39 neurons neuron NNS cord-299949-kmn53e2z 59 40 expressing express VBG cord-299949-kmn53e2z 59 41 CD200 cd200 NN cord-299949-kmn53e2z 59 42 , , , cord-299949-kmn53e2z 59 43 HSP60 HSP60 NNP cord-299949-kmn53e2z 59 44 , , , cord-299949-kmn53e2z 59 45 CD47 CD47 NNP cord-299949-kmn53e2z 59 46 , , , cord-299949-kmn53e2z 59 47 and and CC cord-299949-kmn53e2z 59 48 CD22 CD22 NNP cord-299949-kmn53e2z 59 49 and and CC cord-299949-kmn53e2z 59 50 through through IN cord-299949-kmn53e2z 59 51 the the DT cord-299949-kmn53e2z 59 52 production production NN cord-299949-kmn53e2z 59 53 of of IN cord-299949-kmn53e2z 59 54 neurotrophins neurotrophin NNS cord-299949-kmn53e2z 59 55 ( ( -LRB- cord-299949-kmn53e2z 59 56 Chavarría Chavarría NNP cord-299949-kmn53e2z 59 57 and and CC cord-299949-kmn53e2z 59 58 Cárdenas Cárdenas NNP cord-299949-kmn53e2z 59 59 , , , cord-299949-kmn53e2z 59 60 2013 2013 CD cord-299949-kmn53e2z 59 61 ; ; : cord-299949-kmn53e2z 59 62 Ransohoff Ransohoff NNP cord-299949-kmn53e2z 59 63 and and CC cord-299949-kmn53e2z 59 64 Cardona Cardona NNP cord-299949-kmn53e2z 59 65 , , , cord-299949-kmn53e2z 59 66 2010 2010 CD cord-299949-kmn53e2z 59 67 ; ; : cord-299949-kmn53e2z 59 68 Hoek Hoek NNP cord-299949-kmn53e2z 59 69 et et NNP cord-299949-kmn53e2z 59 70 al al NNP cord-299949-kmn53e2z 59 71 . . NNP cord-299949-kmn53e2z 59 72 , , , cord-299949-kmn53e2z 59 73 2000 2000 CD cord-299949-kmn53e2z 59 74 ) ) -RRB- cord-299949-kmn53e2z 59 75 . . . cord-299949-kmn53e2z 60 1 Local local JJ cord-299949-kmn53e2z 60 2 production production NN cord-299949-kmn53e2z 60 3 of of IN cord-299949-kmn53e2z 60 4 the the DT cord-299949-kmn53e2z 60 5 antiinflammatory antiinflammatory JJ cord-299949-kmn53e2z 60 6 cytokines cytokine NNS cord-299949-kmn53e2z 60 7 transforming transform VBG cord-299949-kmn53e2z 60 8 growth growth NN cord-299949-kmn53e2z 60 9 factor factor NN cord-299949-kmn53e2z 60 10 ( ( -LRB- cord-299949-kmn53e2z 60 11 TGF)-b TGF)-b NNP cord-299949-kmn53e2z 60 12 and and CC cord-299949-kmn53e2z 60 13 IL-10 IL-10 NNP cord-299949-kmn53e2z 60 14 by by IN cord-299949-kmn53e2z 60 15 astrocytes astrocyte NNS cord-299949-kmn53e2z 60 16 , , , cord-299949-kmn53e2z 60 17 pericytes pericyte NNS cord-299949-kmn53e2z 60 18 , , , cord-299949-kmn53e2z 60 19 and and CC cord-299949-kmn53e2z 60 20 meningeal meningeal JJ cord-299949-kmn53e2z 60 21 cells cell NNS cord-299949-kmn53e2z 60 22 further further RB cord-299949-kmn53e2z 60 23 inhibits inhibit VBZ cord-299949-kmn53e2z 60 24 cellular cellular JJ cord-299949-kmn53e2z 60 25 activation activation NN cord-299949-kmn53e2z 60 26 ( ( -LRB- cord-299949-kmn53e2z 60 27 Schwartz Schwartz NNP cord-299949-kmn53e2z 60 28 et et NNP cord-299949-kmn53e2z 60 29 al al NNP cord-299949-kmn53e2z 60 30 . . NNP cord-299949-kmn53e2z 60 31 , , , cord-299949-kmn53e2z 60 32 2013 2013 CD cord-299949-kmn53e2z 60 33 ; ; : cord-299949-kmn53e2z 60 34 Fabry Fabry NNP cord-299949-kmn53e2z 60 35 et et FW cord-299949-kmn53e2z 60 36 al al NNP cord-299949-kmn53e2z 60 37 . . . cord-299949-kmn53e2z 61 1 , , , cord-299949-kmn53e2z 61 2 1995 1995 CD cord-299949-kmn53e2z 61 3 ; ; : cord-299949-kmn53e2z 61 4 Johnson Johnson NNP cord-299949-kmn53e2z 61 5 et et NNP cord-299949-kmn53e2z 61 6 al al NNP cord-299949-kmn53e2z 61 7 . . NNP cord-299949-kmn53e2z 61 8 , , , cord-299949-kmn53e2z 61 9 1992 1992 CD cord-299949-kmn53e2z 61 10 ) ) -RRB- cord-299949-kmn53e2z 61 11 . . . cord-299949-kmn53e2z 62 1 Activated activate VBN cord-299949-kmn53e2z 62 2 T T NNP cord-299949-kmn53e2z 62 3 cells cell NNS cord-299949-kmn53e2z 62 4 cross cross VBP cord-299949-kmn53e2z 62 5 the the DT cord-299949-kmn53e2z 62 6 BBB BBB NNP cord-299949-kmn53e2z 62 7 into into IN cord-299949-kmn53e2z 62 8 the the DT cord-299949-kmn53e2z 62 9 CNS CNS NNP cord-299949-kmn53e2z 62 10 for for IN cord-299949-kmn53e2z 62 11 immunological immunological JJ cord-299949-kmn53e2z 62 12 surveillance surveillance NN cord-299949-kmn53e2z 62 13 upon upon IN cord-299949-kmn53e2z 62 14 interactions interaction NNS cord-299949-kmn53e2z 62 15 with with IN cord-299949-kmn53e2z 62 16 P p NN cord-299949-kmn53e2z 62 17 - - HYPH cord-299949-kmn53e2z 62 18 selectin selectin NN cord-299949-kmn53e2z 62 19 on on IN cord-299949-kmn53e2z 62 20 endothelial endothelial JJ cord-299949-kmn53e2z 62 21 cells cell NNS cord-299949-kmn53e2z 62 22 , , , cord-299949-kmn53e2z 62 23 but but CC cord-299949-kmn53e2z 62 24 leave leave VBP cord-299949-kmn53e2z 62 25 or or CC cord-299949-kmn53e2z 62 26 die die VB cord-299949-kmn53e2z 62 27 if if IN cord-299949-kmn53e2z 62 28 antigen antigen NN cord-299949-kmn53e2z 62 29 is be VBZ cord-299949-kmn53e2z 62 30 not not RB cord-299949-kmn53e2z 62 31 encountered encounter VBN cord-299949-kmn53e2z 62 32 ( ( -LRB- cord-299949-kmn53e2z 62 33 Irani Irani NNP cord-299949-kmn53e2z 62 34 and and CC cord-299949-kmn53e2z 62 35 Griffin Griffin NNP cord-299949-kmn53e2z 62 36 , , , cord-299949-kmn53e2z 62 37 1996 1996 CD cord-299949-kmn53e2z 62 38 ; ; : cord-299949-kmn53e2z 63 1 Wekerle Wekerle NNP cord-299949-kmn53e2z 63 2 et et NNP cord-299949-kmn53e2z 63 3 al al NNP cord-299949-kmn53e2z 63 4 . . . cord-299949-kmn53e2z 64 1 , , , cord-299949-kmn53e2z 64 2 1991 1991 CD cord-299949-kmn53e2z 65 1 Wekerle Wekerle NNP cord-299949-kmn53e2z 65 2 et et NNP cord-299949-kmn53e2z 65 3 al al NNP cord-299949-kmn53e2z 65 4 . . NNP cord-299949-kmn53e2z 65 5 , , , cord-299949-kmn53e2z 65 6 , , , cord-299949-kmn53e2z 65 7 1986 1986 CD cord-299949-kmn53e2z 65 8 . . . cord-299949-kmn53e2z 66 1 The the DT cord-299949-kmn53e2z 66 2 innate innate JJ cord-299949-kmn53e2z 66 3 immune immune JJ cord-299949-kmn53e2z 66 4 response response NN cord-299949-kmn53e2z 66 5 initiated initiate VBN cord-299949-kmn53e2z 66 6 by by IN cord-299949-kmn53e2z 66 7 resident resident JJ cord-299949-kmn53e2z 66 8 cells cell NNS cord-299949-kmn53e2z 66 9 in in IN cord-299949-kmn53e2z 66 10 the the DT cord-299949-kmn53e2z 66 11 CNS CNS NNP cord-299949-kmn53e2z 66 12 upon upon IN cord-299949-kmn53e2z 66 13 virus virus NN cord-299949-kmn53e2z 66 14 infection infection NN cord-299949-kmn53e2z 66 15 is be VBZ cord-299949-kmn53e2z 66 16 the the DT cord-299949-kmn53e2z 66 17 first first JJ cord-299949-kmn53e2z 66 18 line line NN cord-299949-kmn53e2z 66 19 of of IN cord-299949-kmn53e2z 66 20 defense defense NN cord-299949-kmn53e2z 66 21 ( ( -LRB- cord-299949-kmn53e2z 66 22 Figure figure NN cord-299949-kmn53e2z 66 23 2(a 2(a CD cord-299949-kmn53e2z 66 24 ) ) -RRB- cord-299949-kmn53e2z 66 25 ) ) -RRB- cord-299949-kmn53e2z 66 26 . . . cord-299949-kmn53e2z 67 1 Detection detection NN cord-299949-kmn53e2z 67 2 of of IN cord-299949-kmn53e2z 67 3 infection infection NN cord-299949-kmn53e2z 67 4 occurs occur VBZ cord-299949-kmn53e2z 67 5 through through IN cord-299949-kmn53e2z 67 6 activation activation NN cord-299949-kmn53e2z 67 7 of of IN cord-299949-kmn53e2z 67 8 cellular cellular JJ cord-299949-kmn53e2z 67 9 pattern pattern NN cord-299949-kmn53e2z 67 10 recognition recognition NN cord-299949-kmn53e2z 67 11 receptors receptor NNS cord-299949-kmn53e2z 67 12 that that WDT cord-299949-kmn53e2z 67 13 include include VBP cord-299949-kmn53e2z 67 14 the the DT cord-299949-kmn53e2z 67 15 Toll Toll NNP cord-299949-kmn53e2z 67 16 - - HYPH cord-299949-kmn53e2z 67 17 like like JJ cord-299949-kmn53e2z 67 18 receptors receptor NNS cord-299949-kmn53e2z 67 19 ( ( -LRB- cord-299949-kmn53e2z 67 20 TLRs TLRs NNP cord-299949-kmn53e2z 67 21 ) ) -RRB- cord-299949-kmn53e2z 67 22 , , , cord-299949-kmn53e2z 67 23 RIG rig NN cord-299949-kmn53e2z 67 24 - - HYPH cord-299949-kmn53e2z 67 25 I -PRON- PRP cord-299949-kmn53e2z 67 26 - - HYPH cord-299949-kmn53e2z 67 27 like like JJ cord-299949-kmn53e2z 67 28 receptors receptor NNS cord-299949-kmn53e2z 67 29 ( ( -LRB- cord-299949-kmn53e2z 67 30 RLRs RLRs NNP cord-299949-kmn53e2z 67 31 ) ) -RRB- cord-299949-kmn53e2z 67 32 , , , cord-299949-kmn53e2z 67 33 and and CC cord-299949-kmn53e2z 67 34 NOD nod JJ cord-299949-kmn53e2z 67 35 - - HYPH cord-299949-kmn53e2z 67 36 like like JJ cord-299949-kmn53e2z 67 37 receptors receptor NNS cord-299949-kmn53e2z 67 38 ( ( -LRB- cord-299949-kmn53e2z 67 39 NLRs NLRs NNP cord-299949-kmn53e2z 67 40 ) ) -RRB- cord-299949-kmn53e2z 67 41 . . . cord-299949-kmn53e2z 68 1 Microglia Microglia NNP cord-299949-kmn53e2z 68 2 , , , cord-299949-kmn53e2z 68 3 as as IN cord-299949-kmn53e2z 68 4 the the DT cord-299949-kmn53e2z 68 5 professional professional JJ cord-299949-kmn53e2z 68 6 immune immune JJ cord-299949-kmn53e2z 68 7 cells cell NNS cord-299949-kmn53e2z 68 8 of of IN cord-299949-kmn53e2z 68 9 the the DT cord-299949-kmn53e2z 68 10 CNS CNS NNP cord-299949-kmn53e2z 68 11 , , , cord-299949-kmn53e2z 68 12 express express VB cord-299949-kmn53e2z 68 13 all all DT cord-299949-kmn53e2z 68 14 of of IN cord-299949-kmn53e2z 68 15 the the DT cord-299949-kmn53e2z 68 16 known know VBN cord-299949-kmn53e2z 68 17 pattern pattern NN cord-299949-kmn53e2z 68 18 recognition recognition NN cord-299949-kmn53e2z 68 19 receptors receptor NNS cord-299949-kmn53e2z 68 20 . . . cord-299949-kmn53e2z 69 1 Additionally additionally RB cord-299949-kmn53e2z 69 2 , , , cord-299949-kmn53e2z 69 3 neurons neuron NNS cord-299949-kmn53e2z 69 4 , , , cord-299949-kmn53e2z 69 5 astrocytes astrocyte NNS cord-299949-kmn53e2z 69 6 , , , cord-299949-kmn53e2z 69 7 and and CC cord-299949-kmn53e2z 69 8 to to IN cord-299949-kmn53e2z 69 9 a a DT cord-299949-kmn53e2z 69 10 lesser less JJR cord-299949-kmn53e2z 69 11 extent extent NN cord-299949-kmn53e2z 69 12 oligodendrocytes oligodendrocyte NNS cord-299949-kmn53e2z 69 13 , , , cord-299949-kmn53e2z 69 14 express express VB cord-299949-kmn53e2z 69 15 selected select VBN cord-299949-kmn53e2z 69 16 pattern pattern NN cord-299949-kmn53e2z 69 17 recognition recognition NN cord-299949-kmn53e2z 69 18 receptors receptor NNS cord-299949-kmn53e2z 69 19 and and CC cord-299949-kmn53e2z 69 20 thus thus RB cord-299949-kmn53e2z 69 21 contribute contribute VBP cord-299949-kmn53e2z 69 22 to to IN cord-299949-kmn53e2z 69 23 innate innate JJ cord-299949-kmn53e2z 69 24 immune immune JJ cord-299949-kmn53e2z 69 25 signaling signaling NN cord-299949-kmn53e2z 70 1 ( ( -LRB- cord-299949-kmn53e2z 70 2 Kigerl Kigerl NNP cord-299949-kmn53e2z 70 3 et et FW cord-299949-kmn53e2z 70 4 al al NNP cord-299949-kmn53e2z 70 5 . . NNP cord-299949-kmn53e2z 70 6 , , , cord-299949-kmn53e2z 70 7 2014 2014 CD cord-299949-kmn53e2z 70 8 ) ) -RRB- cord-299949-kmn53e2z 70 9 . . . cord-299949-kmn53e2z 71 1 Engagement Engagement NNP cord-299949-kmn53e2z 71 2 of of IN cord-299949-kmn53e2z 71 3 TLRs TLRs NNP cord-299949-kmn53e2z 71 4 and and CC cord-299949-kmn53e2z 71 5 RLRs RLRs NNP cord-299949-kmn53e2z 71 6 activates activate VBZ cord-299949-kmn53e2z 71 7 the the DT cord-299949-kmn53e2z 71 8 transcription transcription NN cord-299949-kmn53e2z 71 9 factors factor NNS cord-299949-kmn53e2z 71 10 IRF-3 IRF-3 NNP cord-299949-kmn53e2z 71 11 , , , cord-299949-kmn53e2z 71 12 IRF-7 IRF-7 NNP cord-299949-kmn53e2z 71 13 , , , cord-299949-kmn53e2z 71 14 and and CC cord-299949-kmn53e2z 71 15 NFkB nfkb UH cord-299949-kmn53e2z 72 1 that that DT cord-299949-kmn53e2z 72 2 control control NN cord-299949-kmn53e2z 72 3 expression expression NN cord-299949-kmn53e2z 72 4 of of IN cord-299949-kmn53e2z 72 5 type type NN cord-299949-kmn53e2z 72 6 - - : cord-299949-kmn53e2z 72 7 I -PRON- PRP cord-299949-kmn53e2z 72 8 interferon interferon NN cord-299949-kmn53e2z 73 1 ( ( -LRB- cord-299949-kmn53e2z 73 2 IFN)-a IFN)-a NNP cord-299949-kmn53e2z 73 3 and and CC cord-299949-kmn53e2z 73 4 IFN IFN NNP cord-299949-kmn53e2z 73 5 - - HYPH cord-299949-kmn53e2z 73 6 b b NNP cord-299949-kmn53e2z 73 7 . . . cord-299949-kmn53e2z 74 1 For for IN cord-299949-kmn53e2z 74 2 many many JJ cord-299949-kmn53e2z 74 3 CNS CNS NNP cord-299949-kmn53e2z 74 4 infections infection NNS cord-299949-kmn53e2z 74 5 , , , cord-299949-kmn53e2z 74 6 IFN IFN NNP cord-299949-kmn53e2z 74 7 production production NN cord-299949-kmn53e2z 74 8 is be VBZ cord-299949-kmn53e2z 74 9 critical critical JJ cord-299949-kmn53e2z 74 10 for for IN cord-299949-kmn53e2z 74 11 early early JJ cord-299949-kmn53e2z 74 12 control control NN cord-299949-kmn53e2z 74 13 of of IN cord-299949-kmn53e2z 74 14 infection infection NN cord-299949-kmn53e2z 74 15 . . . cord-299949-kmn53e2z 75 1 Mice mouse NNS cord-299949-kmn53e2z 75 2 deficient deficient JJ cord-299949-kmn53e2z 75 3 in in IN cord-299949-kmn53e2z 75 4 type type NN cord-299949-kmn53e2z 76 1 -I -I NFP cord-299949-kmn53e2z 76 2 IFN IFN NNP cord-299949-kmn53e2z 76 3 signaling signal VBG cord-299949-kmn53e2z 76 4 , , , cord-299949-kmn53e2z 76 5 IFNAR1 ifnar1 NN cord-299949-kmn53e2z 76 6 À à NN cord-299949-kmn53e2z 76 7 / / SYM cord-299949-kmn53e2z 76 8 À à NN cord-299949-kmn53e2z 76 9 , , , cord-299949-kmn53e2z 76 10 have have VBP cord-299949-kmn53e2z 76 11 increased increase VBN cord-299949-kmn53e2z 76 12 virus virus NN cord-299949-kmn53e2z 76 13 replication replication NN cord-299949-kmn53e2z 76 14 and and CC cord-299949-kmn53e2z 76 15 mortality mortality NN cord-299949-kmn53e2z 76 16 upon upon IN cord-299949-kmn53e2z 76 17 infection infection NN cord-299949-kmn53e2z 76 18 by by IN cord-299949-kmn53e2z 76 19 a a DT cord-299949-kmn53e2z 76 20 variety variety NN cord-299949-kmn53e2z 76 21 of of IN cord-299949-kmn53e2z 76 22 viruses virus NNS cord-299949-kmn53e2z 76 23 including include VBG cord-299949-kmn53e2z 76 24 Sindbis Sindbis NNP cord-299949-kmn53e2z 76 25 virus virus NN cord-299949-kmn53e2z 76 26 ( ( -LRB- cord-299949-kmn53e2z 76 27 SINV SINV NNP cord-299949-kmn53e2z 76 28 ) ) -RRB- cord-299949-kmn53e2z 76 29 , , , cord-299949-kmn53e2z 76 30 West West NNP cord-299949-kmn53e2z 76 31 Nile Nile NNP cord-299949-kmn53e2z 76 32 virus virus NN cord-299949-kmn53e2z 76 33 ( ( -LRB- cord-299949-kmn53e2z 76 34 WNV WNV NNP cord-299949-kmn53e2z 76 35 ) ) -RRB- cord-299949-kmn53e2z 76 36 , , , cord-299949-kmn53e2z 76 37 LCMV LCMV NNP cord-299949-kmn53e2z 76 38 , , , cord-299949-kmn53e2z 76 39 and and CC cord-299949-kmn53e2z 76 40 vesicular vesicular JJ cord-299949-kmn53e2z 76 41 stomatitis stomatitis NN cord-299949-kmn53e2z 76 42 virus virus NN cord-299949-kmn53e2z 76 43 ( ( -LRB- cord-299949-kmn53e2z 76 44 Samuel Samuel NNP cord-299949-kmn53e2z 76 45 and and CC cord-299949-kmn53e2z 76 46 Diamond Diamond NNP cord-299949-kmn53e2z 76 47 , , , cord-299949-kmn53e2z 76 48 2005 2005 CD cord-299949-kmn53e2z 76 49 ; ; : cord-299949-kmn53e2z 76 50 Byrnes Byrnes NNP cord-299949-kmn53e2z 76 51 et et NNP cord-299949-kmn53e2z 76 52 al al NNP cord-299949-kmn53e2z 76 53 . . NNP cord-299949-kmn53e2z 76 54 , , , cord-299949-kmn53e2z 76 55 2000 2000 CD cord-299949-kmn53e2z 76 56 ; ; : cord-299949-kmn53e2z 76 57 Ryman Ryman NNP cord-299949-kmn53e2z 76 58 et et NNP cord-299949-kmn53e2z 76 59 al al NNP cord-299949-kmn53e2z 76 60 . . NNP cord-299949-kmn53e2z 76 61 , , , cord-299949-kmn53e2z 76 62 2000 2000 CD cord-299949-kmn53e2z 76 63 ; ; : cord-299949-kmn53e2z 76 64 Müller Müller NNP cord-299949-kmn53e2z 76 65 et et NNP cord-299949-kmn53e2z 76 66 al al NNP cord-299949-kmn53e2z 76 67 . . NNP cord-299949-kmn53e2z 76 68 , , , cord-299949-kmn53e2z 76 69 1994 1994 CD cord-299949-kmn53e2z 76 70 ) ) -RRB- cord-299949-kmn53e2z 76 71 . . . cord-299949-kmn53e2z 77 1 Moreover moreover RB cord-299949-kmn53e2z 77 2 , , , cord-299949-kmn53e2z 77 3 pretreatment pretreatment NN cord-299949-kmn53e2z 77 4 with with IN cord-299949-kmn53e2z 77 5 IFN IFN NNP cord-299949-kmn53e2z 77 6 is be VBZ cord-299949-kmn53e2z 77 7 protective protective JJ cord-299949-kmn53e2z 77 8 ( ( -LRB- cord-299949-kmn53e2z 78 1 Frolov Frolov NNP cord-299949-kmn53e2z 78 2 et et NNP cord-299949-kmn53e2z 78 3 al al NNP cord-299949-kmn53e2z 78 4 . . . cord-299949-kmn53e2z 79 1 , , , cord-299949-kmn53e2z 79 2 2012 2012 CD cord-299949-kmn53e2z 79 3 ; ; : cord-299949-kmn53e2z 79 4 Lucas Lucas NNP cord-299949-kmn53e2z 79 5 et et NNP cord-299949-kmn53e2z 79 6 al al NNP cord-299949-kmn53e2z 79 7 . . NNP cord-299949-kmn53e2z 79 8 , , , cord-299949-kmn53e2z 79 9 2003 2003 CD cord-299949-kmn53e2z 79 10 ; ; : cord-299949-kmn53e2z 79 11 Grieder Grieder NNP cord-299949-kmn53e2z 79 12 and and CC cord-299949-kmn53e2z 79 13 Vogel Vogel NNP cord-299949-kmn53e2z 79 14 , , , cord-299949-kmn53e2z 79 15 1999 1999 CD cord-299949-kmn53e2z 79 16 ; ; : cord-299949-kmn53e2z 79 17 Després Després NNP cord-299949-kmn53e2z 79 18 et et NNP cord-299949-kmn53e2z 79 19 al al NNP cord-299949-kmn53e2z 79 20 . . NNP cord-299949-kmn53e2z 79 21 , , , cord-299949-kmn53e2z 79 22 1995a 1995a CD cord-299949-kmn53e2z 79 23 ) ) -RRB- cord-299949-kmn53e2z 79 24 . . . cord-299949-kmn53e2z 80 1 IFN IFN NNP cord-299949-kmn53e2z 80 2 signaling signaling NN cord-299949-kmn53e2z 80 3 must must MD cord-299949-kmn53e2z 80 4 be be VB cord-299949-kmn53e2z 80 5 tightly tightly RB cord-299949-kmn53e2z 80 6 regulated regulate VBN cord-299949-kmn53e2z 80 7 as as IN cord-299949-kmn53e2z 80 8 excess excess JJ cord-299949-kmn53e2z 80 9 IFN IFN NNP cord-299949-kmn53e2z 80 10 , , , cord-299949-kmn53e2z 80 11 particularly particularly RB cord-299949-kmn53e2z 80 12 IFN IFN NNP cord-299949-kmn53e2z 80 13 - - HYPH cord-299949-kmn53e2z 80 14 a a NNP cord-299949-kmn53e2z 80 15 , , , cord-299949-kmn53e2z 80 16 can can MD cord-299949-kmn53e2z 80 17 be be VB cord-299949-kmn53e2z 80 18 neurotoxic neurotoxic JJ cord-299949-kmn53e2z 81 1 ( ( -LRB- cord-299949-kmn53e2z 81 2 Nallar Nallar NNP cord-299949-kmn53e2z 81 3 and and CC cord-299949-kmn53e2z 81 4 Kalvakolanu Kalvakolanu NNP cord-299949-kmn53e2z 81 5 , , , cord-299949-kmn53e2z 81 6 2014 2014 CD cord-299949-kmn53e2z 81 7 ; ; : cord-299949-kmn53e2z 81 8 Reyes Reyes NNP cord-299949-kmn53e2z 81 9 - - HYPH cord-299949-kmn53e2z 81 10 Vázquez Vázquez NNP cord-299949-kmn53e2z 81 11 et et NNP cord-299949-kmn53e2z 81 12 al al NNP cord-299949-kmn53e2z 81 13 . . NNP cord-299949-kmn53e2z 81 14 , , , cord-299949-kmn53e2z 81 15 2012 2012 CD cord-299949-kmn53e2z 81 16 ) ) -RRB- cord-299949-kmn53e2z 81 17 . . . cord-299949-kmn53e2z 82 1 In in IN cord-299949-kmn53e2z 82 2 contrast contrast NN cord-299949-kmn53e2z 82 3 , , , cord-299949-kmn53e2z 82 4 IFN IFN NNP cord-299949-kmn53e2z 82 5 - - HYPH cord-299949-kmn53e2z 82 6 b b NNP cord-299949-kmn53e2z 82 7 coordinates coordinate VBZ cord-299949-kmn53e2z 82 8 the the DT cord-299949-kmn53e2z 82 9 immune immune JJ cord-299949-kmn53e2z 82 10 response response NN cord-299949-kmn53e2z 82 11 and and CC cord-299949-kmn53e2z 82 12 is be VBZ cord-299949-kmn53e2z 82 13 generally generally RB cord-299949-kmn53e2z 82 14 neuroprotective neuroprotective JJ cord-299949-kmn53e2z 83 1 ( ( -LRB- cord-299949-kmn53e2z 83 2 McLaurin McLaurin NNP cord-299949-kmn53e2z 83 3 et et NNP cord-299949-kmn53e2z 83 4 al al NNP cord-299949-kmn53e2z 83 5 . . NNP cord-299949-kmn53e2z 83 6 , , , cord-299949-kmn53e2z 83 7 1995 1995 CD cord-299949-kmn53e2z 83 8 ) ) -RRB- cord-299949-kmn53e2z 83 9 . . . cord-299949-kmn53e2z 84 1 Autocrine Autocrine NNP cord-299949-kmn53e2z 84 2 and and CC cord-299949-kmn53e2z 84 3 paracrine paracrine JJ cord-299949-kmn53e2z 84 4 binding binding NN cord-299949-kmn53e2z 84 5 to to IN cord-299949-kmn53e2z 84 6 the the DT cord-299949-kmn53e2z 84 7 ubiquitously ubiquitously RB cord-299949-kmn53e2z 84 8 expressed express VBN cord-299949-kmn53e2z 84 9 IFNa IFNa NNS cord-299949-kmn53e2z 84 10 / / SYM cord-299949-kmn53e2z 84 11 b b NN cord-299949-kmn53e2z 84 12 receptor receptor NN cord-299949-kmn53e2z 84 13 initiates initiate VBZ cord-299949-kmn53e2z 84 14 JAK JAK NNP cord-299949-kmn53e2z 84 15 / / SYM cord-299949-kmn53e2z 84 16 STAT stat NN cord-299949-kmn53e2z 84 17 signaling signal VBG cord-299949-kmn53e2z 84 18 and and CC cord-299949-kmn53e2z 84 19 directs direct VBZ cord-299949-kmn53e2z 84 20 IFN IFN NNP cord-299949-kmn53e2z 84 21 - - HYPH cord-299949-kmn53e2z 84 22 stimulated stimulate VBN cord-299949-kmn53e2z 84 23 gene gene NN cord-299949-kmn53e2z 84 24 ( ( -LRB- cord-299949-kmn53e2z 84 25 ISG ISG NNP cord-299949-kmn53e2z 84 26 ) ) -RRB- cord-299949-kmn53e2z 84 27 expression expression NN cord-299949-kmn53e2z 84 28 . . . cord-299949-kmn53e2z 85 1 ISGs ISGs NNPS cord-299949-kmn53e2z 85 2 restrict restrict VBP cord-299949-kmn53e2z 85 3 virus virus NN cord-299949-kmn53e2z 85 4 replication replication NN cord-299949-kmn53e2z 85 5 in in IN cord-299949-kmn53e2z 85 6 infected infected JJ cord-299949-kmn53e2z 85 7 cells cell NNS cord-299949-kmn53e2z 85 8 and and CC cord-299949-kmn53e2z 85 9 establish establish VB cord-299949-kmn53e2z 85 10 an an DT cord-299949-kmn53e2z 85 11 antiviral antiviral JJ cord-299949-kmn53e2z 85 12 state state NN cord-299949-kmn53e2z 85 13 in in IN cord-299949-kmn53e2z 85 14 neighboring neighboring NN cord-299949-kmn53e2z 85 15 cells cell NNS cord-299949-kmn53e2z 85 16 to to TO cord-299949-kmn53e2z 85 17 limit limit VB cord-299949-kmn53e2z 85 18 virus virus NN cord-299949-kmn53e2z 85 19 spread spread VBN cord-299949-kmn53e2z 85 20 . . . cord-299949-kmn53e2z 86 1 Although although IN cord-299949-kmn53e2z 86 2 IFN IFN NNP cord-299949-kmn53e2z 86 3 signaling signal VBG cord-299949-kmn53e2z 86 4 stimulates stimulate VBZ cord-299949-kmn53e2z 86 5 the the DT cord-299949-kmn53e2z 86 6 expression expression NN cord-299949-kmn53e2z 86 7 of of IN cord-299949-kmn53e2z 86 8 hundreds hundred NNS cord-299949-kmn53e2z 86 9 of of IN cord-299949-kmn53e2z 86 10 ISGs isg NNS cord-299949-kmn53e2z 86 11 , , , cord-299949-kmn53e2z 86 12 antiviral antiviral JJ cord-299949-kmn53e2z 86 13 effects effect NNS cord-299949-kmn53e2z 86 14 Oligodendrocyte Oligodendrocyte NNP cord-299949-kmn53e2z 86 15 : : : cord-299949-kmn53e2z 86 16 Glial glial JJ cord-299949-kmn53e2z 86 17 cell cell NN cord-299949-kmn53e2z 86 18 that that WDT cord-299949-kmn53e2z 86 19 produces produce VBZ cord-299949-kmn53e2z 86 20 the the DT cord-299949-kmn53e2z 86 21 myelin myelin NN cord-299949-kmn53e2z 86 22 sheath sheath NN cord-299949-kmn53e2z 86 23 around around IN cord-299949-kmn53e2z 86 24 neuronal neuronal JJ cord-299949-kmn53e2z 86 25 axons axon NNS cord-299949-kmn53e2z 86 26 and and CC cord-299949-kmn53e2z 86 27 promotes promote VBZ cord-299949-kmn53e2z 86 28 conduction conduction NN cord-299949-kmn53e2z 86 29 Neuron Neuron NNP cord-299949-kmn53e2z 86 30 : : : cord-299949-kmn53e2z 86 31 Electrically electrically RB cord-299949-kmn53e2z 86 32 active active JJ cord-299949-kmn53e2z 86 33 cell cell NN cord-299949-kmn53e2z 86 34 that that WDT cord-299949-kmn53e2z 86 35 transmits transmit VBZ cord-299949-kmn53e2z 86 36 signals signal NNS cord-299949-kmn53e2z 86 37 from from IN cord-299949-kmn53e2z 86 38 the the DT cord-299949-kmn53e2z 86 39 periphery periphery NN cord-299949-kmn53e2z 86 40 and and CC cord-299949-kmn53e2z 86 41 within within IN cord-299949-kmn53e2z 86 42 the the DT cord-299949-kmn53e2z 86 43 CNS CNS NNP cord-299949-kmn53e2z 86 44 Astrocyte Astrocyte NNP cord-299949-kmn53e2z 86 45 : : : cord-299949-kmn53e2z 86 46 Glial glial JJ cord-299949-kmn53e2z 86 47 cell cell NN cord-299949-kmn53e2z 86 48 that that WDT cord-299949-kmn53e2z 86 49 secretes secrete VBZ cord-299949-kmn53e2z 86 50 neuroprotective neuroprotective JJ cord-299949-kmn53e2z 86 51 factors factor NNS cord-299949-kmn53e2z 86 52 and and CC cord-299949-kmn53e2z 86 53 is be VBZ cord-299949-kmn53e2z 86 54 associated associate VBN cord-299949-kmn53e2z 86 55 with with IN cord-299949-kmn53e2z 86 56 maintenance maintenance NN cord-299949-kmn53e2z 86 57 of of IN cord-299949-kmn53e2z 86 58 the the DT cord-299949-kmn53e2z 86 59 BBB BBB NNP cord-299949-kmn53e2z 86 60 Microglial Microglial NNP cord-299949-kmn53e2z 86 61 cell cell NN cord-299949-kmn53e2z 86 62 : : : cord-299949-kmn53e2z 86 63 Bone bone NN cord-299949-kmn53e2z 86 64 marrow marrow NN cord-299949-kmn53e2z 86 65 - - HYPH cord-299949-kmn53e2z 86 66 derived derive VBN cord-299949-kmn53e2z 86 67 macrophage macrophage NN cord-299949-kmn53e2z 86 68 - - HYPH cord-299949-kmn53e2z 86 69 lineage lineage NN cord-299949-kmn53e2z 86 70 glial glial JJ cord-299949-kmn53e2z 86 71 cell cell NN cord-299949-kmn53e2z 86 72 that that WDT cord-299949-kmn53e2z 86 73 is be VBZ cord-299949-kmn53e2z 86 74 the the DT cord-299949-kmn53e2z 86 75 resident resident NN cord-299949-kmn53e2z 86 76 ' ' `` cord-299949-kmn53e2z 86 77 macrophage macrophage NN cord-299949-kmn53e2z 86 78 ' ' '' cord-299949-kmn53e2z 86 79 of of IN cord-299949-kmn53e2z 86 80 the the DT cord-299949-kmn53e2z 86 81 CNS CNS NNP cord-299949-kmn53e2z 86 82 ; ; : cord-299949-kmn53e2z 86 83 constantly constantly RB cord-299949-kmn53e2z 86 84 surveys survey VBZ cord-299949-kmn53e2z 86 85 the the DT cord-299949-kmn53e2z 86 86 CNS CNS NNP cord-299949-kmn53e2z 86 87 and and CC cord-299949-kmn53e2z 86 88 becomes become VBZ cord-299949-kmn53e2z 86 89 immunologically immunologically RB cord-299949-kmn53e2z 86 90 active active JJ cord-299949-kmn53e2z 86 91 upon upon IN cord-299949-kmn53e2z 86 92 pathogen pathogen NN cord-299949-kmn53e2z 86 93 detection detection NN cord-299949-kmn53e2z 86 94 Blood Blood NNP cord-299949-kmn53e2z 86 95 Brain Brain NNP cord-299949-kmn53e2z 86 96 Barrier Barrier NNP cord-299949-kmn53e2z 86 97 ( ( -LRB- cord-299949-kmn53e2z 86 98 BBB BBB NNP cord-299949-kmn53e2z 86 99 ) ) -RRB- cord-299949-kmn53e2z 86 100 : : : cord-299949-kmn53e2z 87 1 Endothelial endothelial JJ cord-299949-kmn53e2z 87 2 cells cell NNS cord-299949-kmn53e2z 87 3 connected connect VBN cord-299949-kmn53e2z 87 4 by by IN cord-299949-kmn53e2z 87 5 tight tight JJ cord-299949-kmn53e2z 87 6 junctions junction NNS cord-299949-kmn53e2z 87 7 that that WDT cord-299949-kmn53e2z 87 8 form form VBP cord-299949-kmn53e2z 87 9 a a DT cord-299949-kmn53e2z 87 10 highly highly RB cord-299949-kmn53e2z 87 11 selective selective JJ cord-299949-kmn53e2z 87 12 barrier barrier NN cord-299949-kmn53e2z 87 13 between between IN cord-299949-kmn53e2z 87 14 the the DT cord-299949-kmn53e2z 87 15 circulating circulate VBG cord-299949-kmn53e2z 87 16 blood blood NN cord-299949-kmn53e2z 87 17 and and CC cord-299949-kmn53e2z 87 18 the the DT cord-299949-kmn53e2z 87 19 CNS CNS NNP cord-299949-kmn53e2z 87 20 parenchyma parenchyma NN cord-299949-kmn53e2z 87 21 of of IN cord-299949-kmn53e2z 87 22 these these DT cord-299949-kmn53e2z 87 23 proteins protein NNS cord-299949-kmn53e2z 87 24 are be VBP cord-299949-kmn53e2z 87 25 both both DT cord-299949-kmn53e2z 87 26 virus virus NN cord-299949-kmn53e2z 87 27 specific specific JJ cord-299949-kmn53e2z 87 28 and and CC cord-299949-kmn53e2z 87 29 tissue tissue NN cord-299949-kmn53e2z 87 30 specific specific JJ cord-299949-kmn53e2z 87 31 ( ( -LRB- cord-299949-kmn53e2z 88 1 Cho Cho NNP cord-299949-kmn53e2z 88 2 et et FW cord-299949-kmn53e2z 88 3 al al NNP cord-299949-kmn53e2z 88 4 . . NNP cord-299949-kmn53e2z 88 5 , , , cord-299949-kmn53e2z 88 6 2013a 2013a CD cord-299949-kmn53e2z 88 7 ; ; : cord-299949-kmn53e2z 88 8 Diamond Diamond NNP cord-299949-kmn53e2z 88 9 and and CC cord-299949-kmn53e2z 88 10 Gale Gale NNP cord-299949-kmn53e2z 88 11 , , , cord-299949-kmn53e2z 88 12 2012 2012 CD cord-299949-kmn53e2z 88 13 ; ; : cord-299949-kmn53e2z 88 14 Schoggins Schoggins NNP cord-299949-kmn53e2z 88 15 et et NNP cord-299949-kmn53e2z 88 16 al al NNP cord-299949-kmn53e2z 88 17 . . NNP cord-299949-kmn53e2z 88 18 , , , cord-299949-kmn53e2z 88 19 2011 2011 CD cord-299949-kmn53e2z 89 1 ; ; : cord-299949-kmn53e2z 89 2 Zhao Zhao NNP cord-299949-kmn53e2z 89 3 et et NNP cord-299949-kmn53e2z 89 4 al al NNP cord-299949-kmn53e2z 89 5 . . NNP cord-299949-kmn53e2z 89 6 , , , cord-299949-kmn53e2z 89 7 2011 2011 CD cord-299949-kmn53e2z 89 8 ) ) -RRB- cord-299949-kmn53e2z 89 9 . . . cord-299949-kmn53e2z 90 1 For for IN cord-299949-kmn53e2z 90 2 instance instance NN cord-299949-kmn53e2z 90 3 , , , cord-299949-kmn53e2z 90 4 the the DT cord-299949-kmn53e2z 90 5 ISG ISG NNP cord-299949-kmn53e2z 90 6 Ifit2 Ifit2 NNP cord-299949-kmn53e2z 90 7 restricts restrict VBZ cord-299949-kmn53e2z 90 8 WNV WNV NNP cord-299949-kmn53e2z 90 9 in in IN cord-299949-kmn53e2z 90 10 some some DT cord-299949-kmn53e2z 90 11 regions region NNS cord-299949-kmn53e2z 90 12 of of IN cord-299949-kmn53e2z 90 13 the the DT cord-299949-kmn53e2z 90 14 brain brain NN cord-299949-kmn53e2z 90 15 , , , cord-299949-kmn53e2z 90 16 but but CC cord-299949-kmn53e2z 90 17 did do VBD cord-299949-kmn53e2z 90 18 not not RB cord-299949-kmn53e2z 90 19 affect affect VB cord-299949-kmn53e2z 90 20 replication replication NN cord-299949-kmn53e2z 90 21 in in IN cord-299949-kmn53e2z 90 22 the the DT cord-299949-kmn53e2z 90 23 cerebral cerebral JJ cord-299949-kmn53e2z 90 24 cortex cortex NN cord-299949-kmn53e2z 90 25 , , , cord-299949-kmn53e2z 90 26 spinal spinal JJ cord-299949-kmn53e2z 90 27 cord cord NN cord-299949-kmn53e2z 90 28 , , , cord-299949-kmn53e2z 90 29 or or CC cord-299949-kmn53e2z 90 30 periphery periphery NN cord-299949-kmn53e2z 90 31 ( ( -LRB- cord-299949-kmn53e2z 91 1 Cho Cho NNP cord-299949-kmn53e2z 91 2 et et FW cord-299949-kmn53e2z 91 3 al al NNP cord-299949-kmn53e2z 91 4 . . NNP cord-299949-kmn53e2z 91 5 , , , cord-299949-kmn53e2z 91 6 2013b 2013b CD cord-299949-kmn53e2z 91 7 ) ) -RRB- cord-299949-kmn53e2z 91 8 . . . cord-299949-kmn53e2z 92 1 Engagement engagement NN cord-299949-kmn53e2z 92 2 of of IN cord-299949-kmn53e2z 92 3 NLRs nlr NNS cord-299949-kmn53e2z 92 4 by by IN cord-299949-kmn53e2z 92 5 infecting infect VBG cord-299949-kmn53e2z 92 6 viruses virus NNS cord-299949-kmn53e2z 92 7 can can MD cord-299949-kmn53e2z 92 8 initiate initiate VB cord-299949-kmn53e2z 92 9 inflammasome inflammasome NN cord-299949-kmn53e2z 92 10 formation formation NN cord-299949-kmn53e2z 92 11 in in IN cord-299949-kmn53e2z 92 12 the the DT cord-299949-kmn53e2z 92 13 CNS CNS NNP cord-299949-kmn53e2z 92 14 . . . cord-299949-kmn53e2z 93 1 The the DT cord-299949-kmn53e2z 93 2 inflammasome inflammasome NN cord-299949-kmn53e2z 93 3 activates activate VBZ cord-299949-kmn53e2z 93 4 caspase-1 caspase-1 NNP cord-299949-kmn53e2z 93 5 to to TO cord-299949-kmn53e2z 93 6 cleave cleave VB cord-299949-kmn53e2z 93 7 precursors precursor NNS cord-299949-kmn53e2z 93 8 of of IN cord-299949-kmn53e2z 93 9 the the DT cord-299949-kmn53e2z 93 10 proinflammatory proinflammatory JJ cord-299949-kmn53e2z 93 11 cytokines cytokine NNS cord-299949-kmn53e2z 93 12 IL-1b IL-1b NNS cord-299949-kmn53e2z 93 13 and and CC cord-299949-kmn53e2z 93 14 IL-18 IL-18 NNP cord-299949-kmn53e2z 93 15 . . . cord-299949-kmn53e2z 93 16 Secretion secretion NN cord-299949-kmn53e2z 93 17 of of IN cord-299949-kmn53e2z 93 18 mature mature JJ cord-299949-kmn53e2z 93 19 IL-1b IL-1b NNS cord-299949-kmn53e2z 93 20 and and CC cord-299949-kmn53e2z 93 21 IL-18 IL-18 NNP cord-299949-kmn53e2z 93 22 helps help VBZ cord-299949-kmn53e2z 93 23 to to TO cord-299949-kmn53e2z 93 24 orchestrate orchestrate VB cord-299949-kmn53e2z 93 25 the the DT cord-299949-kmn53e2z 93 26 inflammatory inflammatory JJ cord-299949-kmn53e2z 93 27 response response NN cord-299949-kmn53e2z 93 28 to to IN cord-299949-kmn53e2z 93 29 infection infection NN cord-299949-kmn53e2z 93 30 . . . cord-299949-kmn53e2z 94 1 The the DT cord-299949-kmn53e2z 94 2 magnitude magnitude NN cord-299949-kmn53e2z 94 3 and and CC cord-299949-kmn53e2z 94 4 timing timing NN cord-299949-kmn53e2z 94 5 of of IN cord-299949-kmn53e2z 94 6 the the DT cord-299949-kmn53e2z 94 7 inflammatory inflammatory JJ cord-299949-kmn53e2z 94 8 response response NN cord-299949-kmn53e2z 94 9 must must MD cord-299949-kmn53e2z 94 10 be be VB cord-299949-kmn53e2z 94 11 controlled control VBN cord-299949-kmn53e2z 94 12 to to TO cord-299949-kmn53e2z 94 13 limit limit VB cord-299949-kmn53e2z 94 14 damage damage NN cord-299949-kmn53e2z 94 15 to to IN cord-299949-kmn53e2z 94 16 bystander bystander NN cord-299949-kmn53e2z 94 17 cells cell NNS cord-299949-kmn53e2z 94 18 . . . cord-299949-kmn53e2z 95 1 Inflammasome Inflammasome NNP cord-299949-kmn53e2z 95 2 - - HYPH cord-299949-kmn53e2z 95 3 mediated mediate VBN cord-299949-kmn53e2z 95 4 signaling signaling NN cord-299949-kmn53e2z 95 5 has have VBZ cord-299949-kmn53e2z 95 6 varying vary VBG cord-299949-kmn53e2z 95 7 affects affect NNS cord-299949-kmn53e2z 95 8 during during IN cord-299949-kmn53e2z 95 9 CNS CNS NNP cord-299949-kmn53e2z 95 10 infections infection NNS cord-299949-kmn53e2z 95 11 ( ( -LRB- cord-299949-kmn53e2z 95 12 Prow Prow NNP cord-299949-kmn53e2z 95 13 and and CC cord-299949-kmn53e2z 95 14 Irani Irani NNP cord-299949-kmn53e2z 95 15 , , , cord-299949-kmn53e2z 95 16 2008 2008 CD cord-299949-kmn53e2z 95 17 ; ; . cord-299949-kmn53e2z 96 1 Sergerie Sergerie NNP cord-299949-kmn53e2z 96 2 et et NNP cord-299949-kmn53e2z 96 3 al al NNP cord-299949-kmn53e2z 96 4 . . NNP cord-299949-kmn53e2z 96 5 , , , cord-299949-kmn53e2z 96 6 2007 2007 CD cord-299949-kmn53e2z 97 1 ; ; : cord-299949-kmn53e2z 97 2 Liang Liang NNP cord-299949-kmn53e2z 97 3 et et NNP cord-299949-kmn53e2z 97 4 al al NNP cord-299949-kmn53e2z 97 5 . . NNP cord-299949-kmn53e2z 97 6 , , , cord-299949-kmn53e2z 97 7 1999 1999 CD cord-299949-kmn53e2z 97 8 ) ) -RRB- cord-299949-kmn53e2z 97 9 . . . cord-299949-kmn53e2z 98 1 Inflammasome Inflammasome NNP cord-299949-kmn53e2z 98 2 activation activation NN cord-299949-kmn53e2z 98 3 during during IN cord-299949-kmn53e2z 98 4 WNV WNV NNP cord-299949-kmn53e2z 98 5 infection infection NN cord-299949-kmn53e2z 98 6 is be VBZ cord-299949-kmn53e2z 98 7 protective protective JJ cord-299949-kmn53e2z 98 8 , , , cord-299949-kmn53e2z 98 9 as as IN cord-299949-kmn53e2z 98 10 mice mouse NNS cord-299949-kmn53e2z 98 11 deficient deficient JJ cord-299949-kmn53e2z 98 12 in in IN cord-299949-kmn53e2z 98 13 inflammasome inflammasome NN cord-299949-kmn53e2z 98 14 components component NNS cord-299949-kmn53e2z 98 15 have have VBP cord-299949-kmn53e2z 98 16 increased increase VBN cord-299949-kmn53e2z 98 17 virus virus NN cord-299949-kmn53e2z 98 18 replication replication NN cord-299949-kmn53e2z 98 19 in in IN cord-299949-kmn53e2z 98 20 the the DT cord-299949-kmn53e2z 98 21 brain brain NN cord-299949-kmn53e2z 98 22 and and CC cord-299949-kmn53e2z 98 23 decreased decrease VBD cord-299949-kmn53e2z 98 24 survival survival NN cord-299949-kmn53e2z 98 25 ( ( -LRB- cord-299949-kmn53e2z 98 26 Kumar Kumar NNP cord-299949-kmn53e2z 98 27 et et NNP cord-299949-kmn53e2z 98 28 al al NNP cord-299949-kmn53e2z 98 29 . . NNP cord-299949-kmn53e2z 98 30 , , , cord-299949-kmn53e2z 98 31 2013 2013 CD cord-299949-kmn53e2z 98 32 ; ; : cord-299949-kmn53e2z 98 33 Ramos Ramos NNP cord-299949-kmn53e2z 98 34 et et NNP cord-299949-kmn53e2z 98 35 al al NNP cord-299949-kmn53e2z 98 36 . . NNP cord-299949-kmn53e2z 98 37 , , , cord-299949-kmn53e2z 98 38 2012 2012 CD cord-299949-kmn53e2z 98 39 ) ) -RRB- cord-299949-kmn53e2z 98 40 . . . cord-299949-kmn53e2z 99 1 In in IN cord-299949-kmn53e2z 99 2 contrast contrast NN cord-299949-kmn53e2z 99 3 , , , cord-299949-kmn53e2z 99 4 inflammasome inflammasome NN cord-299949-kmn53e2z 99 5 activation activation NN cord-299949-kmn53e2z 99 6 in in IN cord-299949-kmn53e2z 99 7 microglia microglia NN cord-299949-kmn53e2z 99 8 and and CC cord-299949-kmn53e2z 99 9 astrocytes astrocyte NNS cord-299949-kmn53e2z 99 10 contributes contribute VBZ cord-299949-kmn53e2z 99 11 to to IN cord-299949-kmn53e2z 99 12 increased increase VBN cord-299949-kmn53e2z 99 13 immunopathology immunopathology NN cord-299949-kmn53e2z 99 14 and and CC cord-299949-kmn53e2z 99 15 possibly possibly RB cord-299949-kmn53e2z 99 16 bystander bystander NN cord-299949-kmn53e2z 99 17 neuronal neuronal JJ cord-299949-kmn53e2z 99 18 death death NN cord-299949-kmn53e2z 99 19 during during IN cord-299949-kmn53e2z 99 20 Japanese japanese JJ cord-299949-kmn53e2z 99 21 encephalitis encephalitis RB cord-299949-kmn53e2z 99 22 virus virus NN cord-299949-kmn53e2z 99 23 infection infection NN cord-299949-kmn53e2z 100 1 ( ( -LRB- cord-299949-kmn53e2z 100 2 Kaushik Kaushik NNP cord-299949-kmn53e2z 100 3 et et NNP cord-299949-kmn53e2z 100 4 al al NNP cord-299949-kmn53e2z 100 5 . . NNP cord-299949-kmn53e2z 100 6 , , , cord-299949-kmn53e2z 100 7 2012 2012 CD cord-299949-kmn53e2z 100 8 ; ; : cord-299949-kmn53e2z 100 9 Das Das NNP cord-299949-kmn53e2z 100 10 et et FW cord-299949-kmn53e2z 100 11 al al NNP cord-299949-kmn53e2z 100 12 . . NNP cord-299949-kmn53e2z 100 13 , , , cord-299949-kmn53e2z 100 14 2008 2008 CD cord-299949-kmn53e2z 100 15 ) ) -RRB- cord-299949-kmn53e2z 100 16 . . . cord-299949-kmn53e2z 101 1 Neurons neuron NNS cord-299949-kmn53e2z 101 2 are be VBP cord-299949-kmn53e2z 101 3 active active JJ cord-299949-kmn53e2z 101 4 contributors contributor NNS cord-299949-kmn53e2z 101 5 to to IN cord-299949-kmn53e2z 101 6 the the DT cord-299949-kmn53e2z 101 7 innate innate JJ cord-299949-kmn53e2z 101 8 immune immune JJ cord-299949-kmn53e2z 101 9 response response NN cord-299949-kmn53e2z 101 10 during during IN cord-299949-kmn53e2z 101 11 virus virus NN cord-299949-kmn53e2z 101 12 infection infection NN cord-299949-kmn53e2z 101 13 as as IN cord-299949-kmn53e2z 101 14 has have VBZ cord-299949-kmn53e2z 101 15 been be VBN cord-299949-kmn53e2z 101 16 demonstrated demonstrate VBN cord-299949-kmn53e2z 101 17 in in IN cord-299949-kmn53e2z 101 18 cultures culture NNS cord-299949-kmn53e2z 101 19 of of IN cord-299949-kmn53e2z 101 20 primary primary JJ cord-299949-kmn53e2z 101 21 and and CC cord-299949-kmn53e2z 101 22 immortalized immortalize VBN cord-299949-kmn53e2z 101 23 neurons neuron NNS cord-299949-kmn53e2z 102 1 ( ( -LRB- cord-299949-kmn53e2z 102 2 Schultz Schultz NNP cord-299949-kmn53e2z 102 3 et et NNP cord-299949-kmn53e2z 102 4 al al NNP cord-299949-kmn53e2z 102 5 . . NNP cord-299949-kmn53e2z 102 6 , , , cord-299949-kmn53e2z 102 7 2014 2014 CD cord-299949-kmn53e2z 102 8 ; ; : cord-299949-kmn53e2z 102 9 Farmer Farmer NNP cord-299949-kmn53e2z 102 10 et et NNP cord-299949-kmn53e2z 102 11 al al NNP cord-299949-kmn53e2z 102 12 . . NNP cord-299949-kmn53e2z 102 13 , , , cord-299949-kmn53e2z 102 14 2013 2013 CD cord-299949-kmn53e2z 102 15 ; ; : cord-299949-kmn53e2z 102 16 Cho Cho NNP cord-299949-kmn53e2z 102 17 et et FW cord-299949-kmn53e2z 102 18 al al NNP cord-299949-kmn53e2z 102 19 . . NNP cord-299949-kmn53e2z 102 20 , , , cord-299949-kmn53e2z 102 21 2013a 2013a CD cord-299949-kmn53e2z 102 22 ; ; : cord-299949-kmn53e2z 102 23 Peltier Peltier NNP cord-299949-kmn53e2z 102 24 et et NNP cord-299949-kmn53e2z 102 25 al al NNP cord-299949-kmn53e2z 102 26 . . NNP cord-299949-kmn53e2z 102 27 , , , cord-299949-kmn53e2z 102 28 2013 2013 CD cord-299949-kmn53e2z 102 29 ; ; : cord-299949-kmn53e2z 103 1 Castorena Castorena NNP cord-299949-kmn53e2z 103 2 et et FW cord-299949-kmn53e2z 103 3 al al NNP cord-299949-kmn53e2z 103 4 . . . cord-299949-kmn53e2z 104 1 , , , cord-299949-kmn53e2z 104 2 2008 2008 CD cord-299949-kmn53e2z 104 3 ; ; : cord-299949-kmn53e2z 104 4 Delhaye Delhaye NNP cord-299949-kmn53e2z 104 5 et et NNP cord-299949-kmn53e2z 104 6 al al NNP cord-299949-kmn53e2z 104 7 . . NNP cord-299949-kmn53e2z 104 8 , , , cord-299949-kmn53e2z 104 9 2006 2006 CD cord-299949-kmn53e2z 104 10 ; ; : cord-299949-kmn53e2z 104 11 Préhaud Préhaud NNP cord-299949-kmn53e2z 104 12 et et NNP cord-299949-kmn53e2z 104 13 al al NNP cord-299949-kmn53e2z 104 14 . . NNP cord-299949-kmn53e2z 104 15 , , , cord-299949-kmn53e2z 104 16 2005 2005 CD cord-299949-kmn53e2z 104 17 ) ) -RRB- cord-299949-kmn53e2z 104 18 . . . cord-299949-kmn53e2z 105 1 In in IN cord-299949-kmn53e2z 105 2 response response NN cord-299949-kmn53e2z 105 3 to to IN cord-299949-kmn53e2z 105 4 alphavirus alphavirus NNP cord-299949-kmn53e2z 105 5 , , , cord-299949-kmn53e2z 105 6 flavivirus flavivirus NNP cord-299949-kmn53e2z 105 7 , , , cord-299949-kmn53e2z 105 8 and and CC cord-299949-kmn53e2z 105 9 bunyavirus bunyavirus NNP cord-299949-kmn53e2z 105 10 infections infection NNS cord-299949-kmn53e2z 105 11 , , , cord-299949-kmn53e2z 105 12 mature mature JJ cord-299949-kmn53e2z 105 13 neurons neuron NNS cord-299949-kmn53e2z 105 14 rapidly rapidly RB cord-299949-kmn53e2z 105 15 activate activate VBP cord-299949-kmn53e2z 105 16 IRF-3 IRF-3 NNP cord-299949-kmn53e2z 105 17 and and CC cord-299949-kmn53e2z 105 18 IRF-7 IRF-7 NNP cord-299949-kmn53e2z 105 19 to to TO cord-299949-kmn53e2z 105 20 induce induce VB cord-299949-kmn53e2z 105 21 expression expression NN cord-299949-kmn53e2z 105 22 of of IN cord-299949-kmn53e2z 105 23 type type NN cord-299949-kmn53e2z 105 24 - - : cord-299949-kmn53e2z 105 25 I -PRON- PRP cord-299949-kmn53e2z 105 26 IFN IFN NNP cord-299949-kmn53e2z 105 27 , , , cord-299949-kmn53e2z 105 28 limit limit VBP cord-299949-kmn53e2z 105 29 virus virus NN cord-299949-kmn53e2z 105 30 replication replication NN cord-299949-kmn53e2z 105 31 , , , cord-299949-kmn53e2z 105 32 and and CC cord-299949-kmn53e2z 105 33 preserve preserve VB cord-299949-kmn53e2z 105 34 neuronal neuronal JJ cord-299949-kmn53e2z 105 35 function function NN cord-299949-kmn53e2z 105 36 ( ( -LRB- cord-299949-kmn53e2z 105 37 Schultz Schultz NNP cord-299949-kmn53e2z 105 38 et et NNP cord-299949-kmn53e2z 105 39 al al NNP cord-299949-kmn53e2z 105 40 . . NNP cord-299949-kmn53e2z 105 41 , , , cord-299949-kmn53e2z 105 42 2014 2014 CD cord-299949-kmn53e2z 105 43 ; ; : cord-299949-kmn53e2z 105 44 Farmer Farmer NNP cord-299949-kmn53e2z 105 45 et et NNP cord-299949-kmn53e2z 105 46 al al NNP cord-299949-kmn53e2z 105 47 . . NNP cord-299949-kmn53e2z 105 48 , , , cord-299949-kmn53e2z 105 49 2013 2013 CD cord-299949-kmn53e2z 105 50 ; ; : cord-299949-kmn53e2z 106 1 Peltier Peltier NNP cord-299949-kmn53e2z 106 2 et et NNP cord-299949-kmn53e2z 106 3 al al NNP cord-299949-kmn53e2z 106 4 . . NNP cord-299949-kmn53e2z 106 5 , , , cord-299949-kmn53e2z 106 6 2010 2010 CD cord-299949-kmn53e2z 107 1 ; ; : cord-299949-kmn53e2z 107 2 Daffis Daffis NNP cord-299949-kmn53e2z 107 3 et et NNP cord-299949-kmn53e2z 107 4 al al NNP cord-299949-kmn53e2z 107 5 . . . cord-299949-kmn53e2z 108 1 , , , cord-299949-kmn53e2z 108 2 2008b 2008b CD cord-299949-kmn53e2z 108 3 ; ; : cord-299949-kmn53e2z 108 4 Castorena Castorena NNP cord-299949-kmn53e2z 108 5 et et FW cord-299949-kmn53e2z 108 6 al al NNP cord-299949-kmn53e2z 108 7 . . NNP cord-299949-kmn53e2z 108 8 , , , cord-299949-kmn53e2z 108 9 2008 2008 CD cord-299949-kmn53e2z 108 10 ; ; : cord-299949-kmn53e2z 108 11 Daffis Daffis NNP cord-299949-kmn53e2z 108 12 et et NNP cord-299949-kmn53e2z 108 13 al al NNP cord-299949-kmn53e2z 108 14 . . NNP cord-299949-kmn53e2z 108 15 , , , cord-299949-kmn53e2z 108 16 2007 2007 CD cord-299949-kmn53e2z 108 17 ) ) -RRB- cord-299949-kmn53e2z 108 18 . . . cord-299949-kmn53e2z 109 1 Additionally additionally RB cord-299949-kmn53e2z 109 2 , , , cord-299949-kmn53e2z 109 3 IL-1b IL-1b NNS cord-299949-kmn53e2z 109 4 synergizes synergize VBZ cord-299949-kmn53e2z 109 5 with with IN cord-299949-kmn53e2z 109 6 IFN IFN NNP cord-299949-kmn53e2z 109 7 - - HYPH cord-299949-kmn53e2z 109 8 b b NNP cord-299949-kmn53e2z 109 9 to to TO cord-299949-kmn53e2z 109 10 control control VB cord-299949-kmn53e2z 109 11 WNV WNV NNP cord-299949-kmn53e2z 109 12 replication replication NN cord-299949-kmn53e2z 109 13 in in IN cord-299949-kmn53e2z 109 14 neurons neuron NNS cord-299949-kmn53e2z 109 15 ( ( -LRB- cord-299949-kmn53e2z 109 16 Ramos Ramos NNP cord-299949-kmn53e2z 109 17 et et NNP cord-299949-kmn53e2z 109 18 al al NNP cord-299949-kmn53e2z 109 19 . . NNP cord-299949-kmn53e2z 109 20 , , , cord-299949-kmn53e2z 109 21 2012 2012 CD cord-299949-kmn53e2z 109 22 ) ) -RRB- cord-299949-kmn53e2z 109 23 . . . cord-299949-kmn53e2z 110 1 The the DT cord-299949-kmn53e2z 110 2 combination combination NN cord-299949-kmn53e2z 110 3 and and CC cord-299949-kmn53e2z 110 4 importance importance NN cord-299949-kmn53e2z 110 5 of of IN cord-299949-kmn53e2z 110 6 each each DT cord-299949-kmn53e2z 110 7 innate innate JJ cord-299949-kmn53e2z 110 8 immune immune JJ cord-299949-kmn53e2z 110 9 signaling signal VBG cord-299949-kmn53e2z 110 10 pathway pathway NN cord-299949-kmn53e2z 110 11 in in IN cord-299949-kmn53e2z 110 12 response response NN cord-299949-kmn53e2z 110 13 to to IN cord-299949-kmn53e2z 110 14 infection infection NN cord-299949-kmn53e2z 110 15 is be VBZ cord-299949-kmn53e2z 110 16 likely likely JJ cord-299949-kmn53e2z 110 17 cell cell NN cord-299949-kmn53e2z 110 18 type type NN cord-299949-kmn53e2z 110 19 and and CC cord-299949-kmn53e2z 110 20 virus virus NN cord-299949-kmn53e2z 110 21 specific specific JJ cord-299949-kmn53e2z 110 22 . . . cord-299949-kmn53e2z 111 1 In in IN cord-299949-kmn53e2z 111 2 addition addition NN cord-299949-kmn53e2z 111 3 to to IN cord-299949-kmn53e2z 111 4 factors factor NNS cord-299949-kmn53e2z 111 5 that that WDT cord-299949-kmn53e2z 111 6 control control VBP cord-299949-kmn53e2z 111 7 virus virus NN cord-299949-kmn53e2z 111 8 replication replication NN cord-299949-kmn53e2z 111 9 , , , cord-299949-kmn53e2z 111 10 infected infected JJ cord-299949-kmn53e2z 111 11 cells cell NNS cord-299949-kmn53e2z 111 12 produce produce VBP cord-299949-kmn53e2z 111 13 factors factor NNS cord-299949-kmn53e2z 111 14 that that WDT cord-299949-kmn53e2z 111 15 activate activate VBP cord-299949-kmn53e2z 111 16 astrocytes astrocyte NNS cord-299949-kmn53e2z 111 17 and and CC cord-299949-kmn53e2z 111 18 microglia microglia NNS cord-299949-kmn53e2z 111 19 , , , cord-299949-kmn53e2z 111 20 upregulate upregulate VB cord-299949-kmn53e2z 111 21 expression expression NN cord-299949-kmn53e2z 111 22 of of IN cord-299949-kmn53e2z 111 23 MHC MHC NNP cord-299949-kmn53e2z 111 24 molecules molecule NNS cord-299949-kmn53e2z 111 25 on on IN cord-299949-kmn53e2z 111 26 microglial microglial JJ cord-299949-kmn53e2z 111 27 cells cell NNS cord-299949-kmn53e2z 111 28 , , , cord-299949-kmn53e2z 111 29 increase increase VB cord-299949-kmn53e2z 111 30 expression expression NN cord-299949-kmn53e2z 111 31 of of IN cord-299949-kmn53e2z 111 32 adhesion adhesion NN cord-299949-kmn53e2z 111 33 molecules molecule NNS cord-299949-kmn53e2z 111 34 including include VBG cord-299949-kmn53e2z 111 35 intercellular intercellular JJ cord-299949-kmn53e2z 111 36 adhesion adhesion NN cord-299949-kmn53e2z 111 37 molecule molecule NN cord-299949-kmn53e2z 111 38 1 1 CD cord-299949-kmn53e2z 111 39 and and CC cord-299949-kmn53e2z 111 40 vascular vascular JJ cord-299949-kmn53e2z 111 41 adhesion adhesion NN cord-299949-kmn53e2z 111 42 molecule molecule NN cord-299949-kmn53e2z 111 43 1(VCAM1 1(vcam1 CD cord-299949-kmn53e2z 111 44 ) ) -RRB- cord-299949-kmn53e2z 111 45 on on IN cord-299949-kmn53e2z 111 46 capillary capillary JJ cord-299949-kmn53e2z 111 47 endothelial endothelial JJ cord-299949-kmn53e2z 111 48 cells cell NNS cord-299949-kmn53e2z 111 49 to to IN cord-299949-kmn53e2z 111 50 direct direct JJ cord-299949-kmn53e2z 111 51 leukocyte leukocyte NN cord-299949-kmn53e2z 111 52 infiltration infiltration NN cord-299949-kmn53e2z 111 53 to to IN cord-299949-kmn53e2z 111 54 the the DT cord-299949-kmn53e2z 111 55 site site NN cord-299949-kmn53e2z 111 56 of of IN cord-299949-kmn53e2z 111 57 infection infection NN cord-299949-kmn53e2z 111 58 , , , cord-299949-kmn53e2z 111 59 and and CC cord-299949-kmn53e2z 111 60 modulate modulate VB cord-299949-kmn53e2z 111 61 the the DT cord-299949-kmn53e2z 111 62 inflammatory inflammatory JJ cord-299949-kmn53e2z 111 63 response response NN cord-299949-kmn53e2z 111 64 . . . cord-299949-kmn53e2z 112 1 Cytokines cytokine NNS cord-299949-kmn53e2z 112 2 and and CC cord-299949-kmn53e2z 112 3 chemokines chemokine NNS cord-299949-kmn53e2z 112 4 important important JJ cord-299949-kmn53e2z 112 5 for for IN cord-299949-kmn53e2z 112 6 these these DT cord-299949-kmn53e2z 112 7 processes process NNS cord-299949-kmn53e2z 112 8 are be VBP cord-299949-kmn53e2z 112 9 induced induce VBN cord-299949-kmn53e2z 112 10 in in IN cord-299949-kmn53e2z 112 11 a a DT cord-299949-kmn53e2z 112 12 virus virus NN cord-299949-kmn53e2z 112 13 - - HYPH cord-299949-kmn53e2z 112 14 specific specific JJ cord-299949-kmn53e2z 112 15 manner manner NN cord-299949-kmn53e2z 112 16 but but CC cord-299949-kmn53e2z 112 17 often often RB cord-299949-kmn53e2z 112 18 include include VBP cord-299949-kmn53e2z 112 19 IFN IFN NNP cord-299949-kmn53e2z 112 20 - - HYPH cord-299949-kmn53e2z 112 21 g g NNP cord-299949-kmn53e2z 112 22 , , , cord-299949-kmn53e2z 112 23 IL-1 IL-1 NNP cord-299949-kmn53e2z 112 24 , , , cord-299949-kmn53e2z 112 25 IL-6 IL-6 NNP cord-299949-kmn53e2z 112 26 , , , cord-299949-kmn53e2z 112 27 IL-10 IL-10 NNP cord-299949-kmn53e2z 112 28 , , , cord-299949-kmn53e2z 112 29 IL-12 IL-12 NNP cord-299949-kmn53e2z 112 30 , , , cord-299949-kmn53e2z 112 31 tumor tumor NN cord-299949-kmn53e2z 112 32 necrosis necrosis NN cord-299949-kmn53e2z 112 33 factor factor NN cord-299949-kmn53e2z 112 34 ( ( -LRB- cord-299949-kmn53e2z 112 35 TNF TNF NNP cord-299949-kmn53e2z 112 36 ) ) -RRB- cord-299949-kmn53e2z 112 37 , , , cord-299949-kmn53e2z 112 38 CCL1 CCL1 NNP cord-299949-kmn53e2z 112 39 , , , cord-299949-kmn53e2z 112 40 CCL2 CCL2 NNP cord-299949-kmn53e2z 112 41 , , , cord-299949-kmn53e2z 112 42 CCL5 CCL5 NNP cord-299949-kmn53e2z 112 43 , , , cord-299949-kmn53e2z 112 44 CXCL9 CXCL9 NNP cord-299949-kmn53e2z 112 45 , , , cord-299949-kmn53e2z 112 46 and and CC cord-299949-kmn53e2z 112 47 CXCL10 CXCL10 NNP cord-299949-kmn53e2z 112 48 ( ( -LRB- cord-299949-kmn53e2z 112 49 Kulcsar Kulcsar NNP cord-299949-kmn53e2z 112 50 et et FW cord-299949-kmn53e2z 112 51 al al NNP cord-299949-kmn53e2z 112 52 . . NNP cord-299949-kmn53e2z 112 53 , , , cord-299949-kmn53e2z 112 54 2014 2014 CD cord-299949-kmn53e2z 112 55 ; ; : cord-299949-kmn53e2z 112 56 Tun Tun NNP cord-299949-kmn53e2z 112 57 et et FW cord-299949-kmn53e2z 112 58 al al NNP cord-299949-kmn53e2z 112 59 . . NNP cord-299949-kmn53e2z 112 60 , , , cord-299949-kmn53e2z 112 61 2014 2014 CD cord-299949-kmn53e2z 112 62 ; ; : cord-299949-kmn53e2z 112 63 Lee Lee NNP cord-299949-kmn53e2z 112 64 et et NNP cord-299949-kmn53e2z 112 65 al al NNP cord-299949-kmn53e2z 112 66 . . NNP cord-299949-kmn53e2z 112 67 , , , cord-299949-kmn53e2z 112 68 2013 2013 CD cord-299949-kmn53e2z 112 69 ; ; : cord-299949-kmn53e2z 112 70 Hayasaka Hayasaka NNP cord-299949-kmn53e2z 112 71 et et NNP cord-299949-kmn53e2z 112 72 al al NNP cord-299949-kmn53e2z 112 73 . . NNP cord-299949-kmn53e2z 112 74 , , , cord-299949-kmn53e2z 112 75 2013 2013 CD cord-299949-kmn53e2z 112 76 ; ; : cord-299949-kmn53e2z 112 77 Metcalf Metcalf NNP cord-299949-kmn53e2z 112 78 et et NNP cord-299949-kmn53e2z 112 79 al al NNP cord-299949-kmn53e2z 112 80 . . NNP cord-299949-kmn53e2z 112 81 , , , cord-299949-kmn53e2z 112 82 2013 2013 CD cord-299949-kmn53e2z 112 83 ; ; : cord-299949-kmn53e2z 112 84 Ramos Ramos NNP cord-299949-kmn53e2z 112 85 et et NNP cord-299949-kmn53e2z 112 86 al al NNP cord-299949-kmn53e2z 112 87 . . NNP cord-299949-kmn53e2z 112 88 , , , cord-299949-kmn53e2z 112 89 2012 2012 CD cord-299949-kmn53e2z 112 90 ; ; : cord-299949-kmn53e2z 112 91 Stubblefield Stubblefield NNP cord-299949-kmn53e2z 112 92 Park Park NNP cord-299949-kmn53e2z 112 93 et et NNP cord-299949-kmn53e2z 112 94 al al NNP cord-299949-kmn53e2z 112 95 . . NNP cord-299949-kmn53e2z 112 96 , , , cord-299949-kmn53e2z 112 97 2011 2011 CD cord-299949-kmn53e2z 112 98 ; ; : cord-299949-kmn53e2z 112 99 Shrestha Shrestha NNP cord-299949-kmn53e2z 112 100 et et NNP cord-299949-kmn53e2z 112 101 al al NNP cord-299949-kmn53e2z 112 102 . . NNP cord-299949-kmn53e2z 112 103 , , , cord-299949-kmn53e2z 112 104 2006 2006 CD cord-299949-kmn53e2z 112 105 ; ; : cord-299949-kmn53e2z 112 106 Klein Klein NNP cord-299949-kmn53e2z 112 107 et et NNP cord-299949-kmn53e2z 112 108 al al NNP cord-299949-kmn53e2z 112 109 . . NNP cord-299949-kmn53e2z 112 110 , , , cord-299949-kmn53e2z 112 111 2005 2005 CD cord-299949-kmn53e2z 112 112 ; ; : cord-299949-kmn53e2z 112 113 Burdeinick Burdeinick NNP cord-299949-kmn53e2z 112 114 - - HYPH cord-299949-kmn53e2z 112 115 Kerr Kerr NNP cord-299949-kmn53e2z 112 116 and and CC cord-299949-kmn53e2z 112 117 Griffin Griffin NNP cord-299949-kmn53e2z 112 118 , , , cord-299949-kmn53e2z 112 119 2005 2005 CD cord-299949-kmn53e2z 112 120 ; ; : cord-299949-kmn53e2z 112 121 Bergmann Bergmann NNP cord-299949-kmn53e2z 112 122 et et NNP cord-299949-kmn53e2z 112 123 al al NNP cord-299949-kmn53e2z 112 124 . . NNP cord-299949-kmn53e2z 112 125 , , , cord-299949-kmn53e2z 112 126 2004 2004 CD cord-299949-kmn53e2z 112 127 ; ; : cord-299949-kmn53e2z 112 128 Chang Chang NNP cord-299949-kmn53e2z 112 129 et et NNP cord-299949-kmn53e2z 112 130 al al NNP cord-299949-kmn53e2z 112 131 . . NNP cord-299949-kmn53e2z 112 132 , , , cord-299949-kmn53e2z 112 133 2000 2000 CD cord-299949-kmn53e2z 112 134 ; ; : cord-299949-kmn53e2z 112 135 Liang Liang NNP cord-299949-kmn53e2z 112 136 et et NNP cord-299949-kmn53e2z 112 137 al al NNP cord-299949-kmn53e2z 112 138 . . NNP cord-299949-kmn53e2z 112 139 , , , cord-299949-kmn53e2z 112 140 1999 1999 CD cord-299949-kmn53e2z 112 141 ) ) -RRB- cord-299949-kmn53e2z 112 142 . . . cord-299949-kmn53e2z 113 1 These these DT cord-299949-kmn53e2z 113 2 factors factor NNS cord-299949-kmn53e2z 113 3 facilitate facilitate VBP cord-299949-kmn53e2z 113 4 recruitment recruitment NN cord-299949-kmn53e2z 113 5 of of IN cord-299949-kmn53e2z 113 6 circulating circulate VBG cord-299949-kmn53e2z 113 7 leukocytes leukocyte NNS cord-299949-kmn53e2z 113 8 across across IN cord-299949-kmn53e2z 113 9 the the DT cord-299949-kmn53e2z 113 10 BBB BBB NNP cord-299949-kmn53e2z 113 11 and and CC cord-299949-kmn53e2z 113 12 into into IN cord-299949-kmn53e2z 113 13 the the DT cord-299949-kmn53e2z 113 14 CNS CNS NNP cord-299949-kmn53e2z 113 15 . . . cord-299949-kmn53e2z 114 1 In in IN cord-299949-kmn53e2z 114 2 addition addition NN cord-299949-kmn53e2z 114 3 to to IN cord-299949-kmn53e2z 114 4 controlling control VBG cord-299949-kmn53e2z 114 5 virus virus NN cord-299949-kmn53e2z 114 6 replication replication NN cord-299949-kmn53e2z 114 7 in in IN cord-299949-kmn53e2z 114 8 CNS CNS NNP cord-299949-kmn53e2z 114 9 cells cell NNS cord-299949-kmn53e2z 114 10 , , , cord-299949-kmn53e2z 114 11 innate innate JJ cord-299949-kmn53e2z 114 12 immune immune JJ cord-299949-kmn53e2z 114 13 signaling signaling NN cord-299949-kmn53e2z 114 14 initiates initiate VBZ cord-299949-kmn53e2z 114 15 the the DT cord-299949-kmn53e2z 114 16 virus virus NN cord-299949-kmn53e2z 114 17 - - HYPH cord-299949-kmn53e2z 114 18 specific specific JJ cord-299949-kmn53e2z 114 19 adaptive adaptive JJ cord-299949-kmn53e2z 114 20 immune immune JJ cord-299949-kmn53e2z 114 21 response response NN cord-299949-kmn53e2z 114 22 . . . cord-299949-kmn53e2z 115 1 Infiltration infiltration NN cord-299949-kmn53e2z 115 2 of of IN cord-299949-kmn53e2z 115 3 mononuclear mononuclear JJ cord-299949-kmn53e2z 115 4 inflammatory inflammatory JJ cord-299949-kmn53e2z 115 5 cells cell NNS cord-299949-kmn53e2z 115 6 into into IN cord-299949-kmn53e2z 115 7 the the DT cord-299949-kmn53e2z 115 8 CNS CNS NNP cord-299949-kmn53e2z 115 9 typically typically RB cord-299949-kmn53e2z 115 10 begins begin VBZ cord-299949-kmn53e2z 115 11 3 3 CD cord-299949-kmn53e2z 115 12 - - SYM cord-299949-kmn53e2z 115 13 4 4 CD cord-299949-kmn53e2z 115 14 days day NNS cord-299949-kmn53e2z 115 15 after after IN cord-299949-kmn53e2z 115 16 infection infection NN cord-299949-kmn53e2z 115 17 ( ( -LRB- cord-299949-kmn53e2z 115 18 Figure figure NN cord-299949-kmn53e2z 115 19 2(b 2(b CD cord-299949-kmn53e2z 115 20 ) ) -RRB- cord-299949-kmn53e2z 115 21 and and CC cord-299949-kmn53e2z 115 22 2(c 2(c LS cord-299949-kmn53e2z 115 23 ) ) -RRB- cord-299949-kmn53e2z 115 24 ) ) -RRB- cord-299949-kmn53e2z 115 25 . . . cord-299949-kmn53e2z 116 1 T T NNP cord-299949-kmn53e2z 116 2 cell cell NN cord-299949-kmn53e2z 116 3 and and CC cord-299949-kmn53e2z 116 4 B b NN cord-299949-kmn53e2z 116 5 cell cell NN cord-299949-kmn53e2z 116 6 trafficking trafficking NN cord-299949-kmn53e2z 116 7 into into IN cord-299949-kmn53e2z 116 8 the the DT cord-299949-kmn53e2z 116 9 CNS CNS NNP cord-299949-kmn53e2z 116 10 is be VBZ cord-299949-kmn53e2z 116 11 promoted promote VBN cord-299949-kmn53e2z 116 12 by by IN cord-299949-kmn53e2z 116 13 neuronal neuronal JJ cord-299949-kmn53e2z 116 14 expression expression NN cord-299949-kmn53e2z 116 15 of of IN cord-299949-kmn53e2z 116 16 the the DT cord-299949-kmn53e2z 116 17 chemokine chemokine NN cord-299949-kmn53e2z 116 18 CXCL10 CXCL10 NNP cord-299949-kmn53e2z 116 19 that that WDT cord-299949-kmn53e2z 116 20 binds bind VBZ cord-299949-kmn53e2z 116 21 to to IN cord-299949-kmn53e2z 116 22 CXCR3 cxcr3 NN cord-299949-kmn53e2z 116 23 on on RP cord-299949-kmn53e2z 116 24 activated activate VBN cord-299949-kmn53e2z 116 25 T T NNP cord-299949-kmn53e2z 116 26 cell cell NN cord-299949-kmn53e2z 116 27 and and CC cord-299949-kmn53e2z 116 28 B b NN cord-299949-kmn53e2z 116 29 cell cell NN cord-299949-kmn53e2z 117 1 ( ( -LRB- cord-299949-kmn53e2z 117 2 Phares Phares NNP cord-299949-kmn53e2z 117 3 et et NNP cord-299949-kmn53e2z 117 4 al al NNP cord-299949-kmn53e2z 117 5 . . NNP cord-299949-kmn53e2z 117 6 , , , cord-299949-kmn53e2z 117 7 2013 2013 CD cord-299949-kmn53e2z 117 8 ; ; : cord-299949-kmn53e2z 118 1 Zhang Zhang NNP cord-299949-kmn53e2z 118 2 et et NNP cord-299949-kmn53e2z 118 3 al al NNP cord-299949-kmn53e2z 118 4 . . NNP cord-299949-kmn53e2z 118 5 , , , cord-299949-kmn53e2z 118 6 2008 2008 CD cord-299949-kmn53e2z 118 7 ; ; : cord-299949-kmn53e2z 118 8 Klein Klein NNP cord-299949-kmn53e2z 118 9 et et NNP cord-299949-kmn53e2z 118 10 al al NNP cord-299949-kmn53e2z 118 11 . . NNP cord-299949-kmn53e2z 118 12 , , , cord-299949-kmn53e2z 118 13 2005 2005 CD cord-299949-kmn53e2z 118 14 ) ) -RRB- cord-299949-kmn53e2z 118 15 . . . cord-299949-kmn53e2z 119 1 Additionally additionally RB cord-299949-kmn53e2z 119 2 , , , cord-299949-kmn53e2z 119 3 proper proper JJ cord-299949-kmn53e2z 119 4 trafficking trafficking NN cord-299949-kmn53e2z 119 5 of of IN cord-299949-kmn53e2z 119 6 T t NN cord-299949-kmn53e2z 119 7 cells cell NNS cord-299949-kmn53e2z 119 8 to to IN cord-299949-kmn53e2z 119 9 appropriate appropriate JJ cord-299949-kmn53e2z 119 10 brain brain NN cord-299949-kmn53e2z 119 11 regions region NNS cord-299949-kmn53e2z 119 12 is be VBZ cord-299949-kmn53e2z 119 13 promoted promote VBN cord-299949-kmn53e2z 119 14 by by IN cord-299949-kmn53e2z 119 15 signaling signal VBG cord-299949-kmn53e2z 119 16 through through IN cord-299949-kmn53e2z 119 17 CCR5 CCR5 NNP cord-299949-kmn53e2z 119 18 and and CC cord-299949-kmn53e2z 119 19 CXCR4 CXCR4 NNP cord-299949-kmn53e2z 120 1 ( ( -LRB- cord-299949-kmn53e2z 120 2 McCandless McCandless NNP cord-299949-kmn53e2z 120 3 et et NNP cord-299949-kmn53e2z 120 4 al al NNP cord-299949-kmn53e2z 120 5 . . NNP cord-299949-kmn53e2z 120 6 , , , cord-299949-kmn53e2z 120 7 2008 2008 CD cord-299949-kmn53e2z 120 8 ) ) -RRB- cord-299949-kmn53e2z 120 9 . . . cord-299949-kmn53e2z 121 1 Cells cell NNS cord-299949-kmn53e2z 121 2 first first RB cord-299949-kmn53e2z 121 3 accumulate accumulate VBP cord-299949-kmn53e2z 121 4 in in IN cord-299949-kmn53e2z 121 5 the the DT cord-299949-kmn53e2z 121 6 perivascular perivascular JJ cord-299949-kmn53e2z 121 7 areas area NNS cord-299949-kmn53e2z 121 8 and and CC cord-299949-kmn53e2z 121 9 then then RB cord-299949-kmn53e2z 121 10 infiltrate infiltrate VB cord-299949-kmn53e2z 121 11 the the DT cord-299949-kmn53e2z 121 12 parenchyma parenchyma NN cord-299949-kmn53e2z 121 13 in in IN cord-299949-kmn53e2z 121 14 the the DT cord-299949-kmn53e2z 121 15 regions region NNS cord-299949-kmn53e2z 121 16 of of IN cord-299949-kmn53e2z 121 17 virus virus NN cord-299949-kmn53e2z 121 18 infection infection NN cord-299949-kmn53e2z 121 19 . . . cord-299949-kmn53e2z 122 1 Essentially essentially RB cord-299949-kmn53e2z 122 2 , , , cord-299949-kmn53e2z 122 3 all all DT cord-299949-kmn53e2z 122 4 components component NNS cord-299949-kmn53e2z 122 5 of of IN cord-299949-kmn53e2z 122 6 the the DT cord-299949-kmn53e2z 122 7 cellular cellular JJ cord-299949-kmn53e2z 122 8 immune immune JJ cord-299949-kmn53e2z 122 9 response response NN cord-299949-kmn53e2z 122 10 are be VBP cord-299949-kmn53e2z 122 11 detected detect VBN cord-299949-kmn53e2z 122 12 in in IN cord-299949-kmn53e2z 122 13 the the DT cord-299949-kmn53e2z 122 14 infiltrate infiltrate NN cord-299949-kmn53e2z 122 15 : : : cord-299949-kmn53e2z 122 16 natural natural JJ cord-299949-kmn53e2z 122 17 killer killer NN cord-299949-kmn53e2z 122 18 ( ( -LRB- cord-299949-kmn53e2z 122 19 NK NK NNP cord-299949-kmn53e2z 122 20 ) ) -RRB- cord-299949-kmn53e2z 122 21 cells cell NNS cord-299949-kmn53e2z 122 22 , , , cord-299949-kmn53e2z 122 23 antigen antigen NN cord-299949-kmn53e2z 122 24 - - HYPH cord-299949-kmn53e2z 122 25 specific specific JJ cord-299949-kmn53e2z 122 26 CD4 CD4 NNP cord-299949-kmn53e2z 122 27 þ þ NNP cord-299949-kmn53e2z 122 28 and and CC cord-299949-kmn53e2z 122 29 CD8 CD8 NNP cord-299949-kmn53e2z 122 30 þ þ NNP cord-299949-kmn53e2z 122 31 T T NNP cord-299949-kmn53e2z 122 32 cells cell NNS cord-299949-kmn53e2z 122 33 , , , cord-299949-kmn53e2z 122 34 B b NN cord-299949-kmn53e2z 122 35 cells cell NNS cord-299949-kmn53e2z 122 36 , , , cord-299949-kmn53e2z 122 37 and and CC cord-299949-kmn53e2z 122 38 monocytes monocyte NNS cord-299949-kmn53e2z 122 39 / / SYM cord-299949-kmn53e2z 122 40 macrophages macrophage NNS cord-299949-kmn53e2z 122 41 ( ( -LRB- cord-299949-kmn53e2z 122 42 Peña Peña NNP cord-299949-kmn53e2z 122 43 et et NNP cord-299949-kmn53e2z 122 44 al al NNP cord-299949-kmn53e2z 122 45 . . NNP cord-299949-kmn53e2z 122 46 , , , cord-299949-kmn53e2z 122 47 2014 2014 CD cord-299949-kmn53e2z 122 48 ; ; : cord-299949-kmn53e2z 122 49 Zhao Zhao NNP cord-299949-kmn53e2z 122 50 et et NNP cord-299949-kmn53e2z 122 51 al al NNP cord-299949-kmn53e2z 122 52 . . NNP cord-299949-kmn53e2z 122 53 , , , cord-299949-kmn53e2z 122 54 2013 2013 CD cord-299949-kmn53e2z 122 55 ; ; : cord-299949-kmn53e2z 123 1 Lee Lee NNP cord-299949-kmn53e2z 123 2 et et NNP cord-299949-kmn53e2z 123 3 al al NNP cord-299949-kmn53e2z 123 4 . . . cord-299949-kmn53e2z 124 1 , , , cord-299949-kmn53e2z 124 2 2013 2013 CD cord-299949-kmn53e2z 124 3 ; ; : cord-299949-kmn53e2z 124 4 Chang Chang NNP cord-299949-kmn53e2z 124 5 et et NNP cord-299949-kmn53e2z 124 6 al al NNP cord-299949-kmn53e2z 124 7 . . NNP cord-299949-kmn53e2z 124 8 , , , cord-299949-kmn53e2z 124 9 2000 2000 CD cord-299949-kmn53e2z 124 10 ; ; : cord-299949-kmn53e2z 124 11 Rowell Rowell NNP cord-299949-kmn53e2z 124 12 and and CC cord-299949-kmn53e2z 124 13 Griffin Griffin NNP cord-299949-kmn53e2z 124 14 , , , cord-299949-kmn53e2z 124 15 1999 1999 CD cord-299949-kmn53e2z 124 16 ; ; : cord-299949-kmn53e2z 124 17 Parra Parra NNP cord-299949-kmn53e2z 124 18 et et NNP cord-299949-kmn53e2z 124 19 al al NNP cord-299949-kmn53e2z 124 20 . . NNP cord-299949-kmn53e2z 124 21 , , , cord-299949-kmn53e2z 124 22 1997 1997 CD cord-299949-kmn53e2z 124 23 ; ; : cord-299949-kmn53e2z 124 24 Pearce Pearce NNP cord-299949-kmn53e2z 124 25 et et NNP cord-299949-kmn53e2z 124 26 al al NNP cord-299949-kmn53e2z 124 27 . . NNP cord-299949-kmn53e2z 124 28 , , , cord-299949-kmn53e2z 124 29 1994 1994 CD cord-299949-kmn53e2z 124 30 ; ; : cord-299949-kmn53e2z 124 31 Wesselingh Wesselingh NNP cord-299949-kmn53e2z 124 32 et et NNP cord-299949-kmn53e2z 124 33 al al NNP cord-299949-kmn53e2z 124 34 . . NNP cord-299949-kmn53e2z 124 35 , , , cord-299949-kmn53e2z 124 36 1994 1994 CD cord-299949-kmn53e2z 124 37 ) ) -RRB- cord-299949-kmn53e2z 124 38 . . . cord-299949-kmn53e2z 125 1 The the DT cord-299949-kmn53e2z 125 2 uninfected uninfected JJ cord-299949-kmn53e2z 125 3 CNS CNS NNP cord-299949-kmn53e2z 125 4 does do VBZ cord-299949-kmn53e2z 125 5 not not RB cord-299949-kmn53e2z 125 6 have have VB cord-299949-kmn53e2z 125 7 professional professional JJ cord-299949-kmn53e2z 125 8 antigen antigen NN cord-299949-kmn53e2z 125 9 - - HYPH cord-299949-kmn53e2z 125 10 presenting present VBG cord-299949-kmn53e2z 125 11 cells cell NNS cord-299949-kmn53e2z 125 12 capable capable JJ cord-299949-kmn53e2z 125 13 of of IN cord-299949-kmn53e2z 125 14 activating activate VBG cord-299949-kmn53e2z 125 15 naïve naïve JJ cord-299949-kmn53e2z 125 16 T t NN cord-299949-kmn53e2z 125 17 cells cell NNS cord-299949-kmn53e2z 125 18 , , , cord-299949-kmn53e2z 125 19 but but CC cord-299949-kmn53e2z 125 20 dendritic dendritic JJ cord-299949-kmn53e2z 125 21 cells cell NNS cord-299949-kmn53e2z 125 22 are be VBP cord-299949-kmn53e2z 125 23 detected detect VBN cord-299949-kmn53e2z 125 24 in in IN cord-299949-kmn53e2z 125 25 the the DT cord-299949-kmn53e2z 125 26 CNS CNS NNP cord-299949-kmn53e2z 125 27 during during IN cord-299949-kmn53e2z 125 28 inflammation inflammation NN cord-299949-kmn53e2z 125 29 after after IN cord-299949-kmn53e2z 125 30 either either CC cord-299949-kmn53e2z 125 31 entering enter VBG cord-299949-kmn53e2z 125 32 from from IN cord-299949-kmn53e2z 125 33 the the DT cord-299949-kmn53e2z 125 34 circulation circulation NN cord-299949-kmn53e2z 125 35 or or CC cord-299949-kmn53e2z 125 36 developing develop VBG cord-299949-kmn53e2z 125 37 from from IN cord-299949-kmn53e2z 125 38 a a DT cord-299949-kmn53e2z 125 39 subpopulation subpopulation NN cord-299949-kmn53e2z 125 40 of of IN cord-299949-kmn53e2z 125 41 activated activate VBN cord-299949-kmn53e2z 125 42 microglia microglia NNS cord-299949-kmn53e2z 125 43 . . . cord-299949-kmn53e2z 126 1 Presentation presentation NN cord-299949-kmn53e2z 126 2 of of IN cord-299949-kmn53e2z 126 3 viral viral JJ cord-299949-kmn53e2z 126 4 peptide peptide NN cord-299949-kmn53e2z 126 5 antigen antigen NN cord-299949-kmn53e2z 126 6 in in IN cord-299949-kmn53e2z 126 7 association association NN cord-299949-kmn53e2z 126 8 with with IN cord-299949-kmn53e2z 126 9 the the DT cord-299949-kmn53e2z 126 10 appropriate appropriate JJ cord-299949-kmn53e2z 126 11 MHC MHC NNP cord-299949-kmn53e2z 126 12 molecules molecule NNS cord-299949-kmn53e2z 126 13 , , , cord-299949-kmn53e2z 126 14 predominantly predominantly RB cord-299949-kmn53e2z 126 15 expressed express VBN cord-299949-kmn53e2z 126 16 on on IN cord-299949-kmn53e2z 126 17 glial glial JJ cord-299949-kmn53e2z 126 18 cells cell NNS cord-299949-kmn53e2z 126 19 , , , cord-299949-kmn53e2z 126 20 retains retain VBZ cord-299949-kmn53e2z 126 21 activated activate VBN cord-299949-kmn53e2z 126 22 T T NNP cord-299949-kmn53e2z 126 23 cells cell NNS cord-299949-kmn53e2z 126 24 in in IN cord-299949-kmn53e2z 126 25 the the DT cord-299949-kmn53e2z 126 26 CNS CNS NNP cord-299949-kmn53e2z 126 27 ( ( -LRB- cord-299949-kmn53e2z 126 28 Kimura Kimura NNP cord-299949-kmn53e2z 126 29 and and CC cord-299949-kmn53e2z 126 30 Griffin Griffin NNP cord-299949-kmn53e2z 126 31 , , , cord-299949-kmn53e2z 126 32 2000 2000 CD cord-299949-kmn53e2z 126 33 ; ; : cord-299949-kmn53e2z 126 34 Irani Irani NNP cord-299949-kmn53e2z 126 35 and and CC cord-299949-kmn53e2z 126 36 Griffin Griffin NNP cord-299949-kmn53e2z 126 37 , , , cord-299949-kmn53e2z 126 38 1996 1996 CD cord-299949-kmn53e2z 126 39 ; ; : cord-299949-kmn53e2z 126 40 Suzumura Suzumura NNP cord-299949-kmn53e2z 126 41 et et NNP cord-299949-kmn53e2z 126 42 al al NNP cord-299949-kmn53e2z 126 43 . . NNP cord-299949-kmn53e2z 126 44 , , , cord-299949-kmn53e2z 126 45 1988 1988 CD cord-299949-kmn53e2z 126 46 ) ) -RRB- cord-299949-kmn53e2z 126 47 . . . cord-299949-kmn53e2z 127 1 The the DT cord-299949-kmn53e2z 127 2 continued continued JJ cord-299949-kmn53e2z 127 3 presence presence NN cord-299949-kmn53e2z 127 4 of of IN cord-299949-kmn53e2z 127 5 viral viral JJ cord-299949-kmn53e2z 127 6 protein protein NN cord-299949-kmn53e2z 127 7 antigens antigen NNS cord-299949-kmn53e2z 127 8 promotes promote VBZ cord-299949-kmn53e2z 127 9 long long JJ cord-299949-kmn53e2z 127 10 - - HYPH cord-299949-kmn53e2z 127 11 term term NN cord-299949-kmn53e2z 127 12 retention retention NN cord-299949-kmn53e2z 127 13 of of IN cord-299949-kmn53e2z 127 14 virus virus NN cord-299949-kmn53e2z 127 15 - - HYPH cord-299949-kmn53e2z 127 16 specific specific JJ cord-299949-kmn53e2z 127 17 B b NN cord-299949-kmn53e2z 127 18 cells cell NNS cord-299949-kmn53e2z 128 1 ( ( -LRB- cord-299949-kmn53e2z 128 2 Phares Phares NNP cord-299949-kmn53e2z 128 3 et et NNP cord-299949-kmn53e2z 128 4 al al NNP cord-299949-kmn53e2z 128 5 . . NNP cord-299949-kmn53e2z 128 6 , , , cord-299949-kmn53e2z 128 7 2013 2013 CD cord-299949-kmn53e2z 128 8 ; ; : cord-299949-kmn53e2z 128 9 Metcalf Metcalf NNP cord-299949-kmn53e2z 128 10 et et NNP cord-299949-kmn53e2z 128 11 al al NNP cord-299949-kmn53e2z 128 12 . . NNP cord-299949-kmn53e2z 128 13 , , , cord-299949-kmn53e2z 128 14 2013 2013 CD cord-299949-kmn53e2z 128 15 ) ) -RRB- cord-299949-kmn53e2z 128 16 . . . cord-299949-kmn53e2z 129 1 Virus virus NN cord-299949-kmn53e2z 129 2 is be VBZ cord-299949-kmn53e2z 129 3 cleared clear VBN cord-299949-kmn53e2z 129 4 from from IN cord-299949-kmn53e2z 129 5 the the DT cord-299949-kmn53e2z 129 6 CNS CNS NNP cord-299949-kmn53e2z 129 7 in in IN cord-299949-kmn53e2z 129 8 a a DT cord-299949-kmn53e2z 129 9 multistep multistep JJ cord-299949-kmn53e2z 129 10 process process NN cord-299949-kmn53e2z 129 11 that that WDT cord-299949-kmn53e2z 129 12 must must MD cord-299949-kmn53e2z 129 13 first first RB cord-299949-kmn53e2z 129 14 stop stop VB cord-299949-kmn53e2z 129 15 cell cell NN cord-299949-kmn53e2z 129 16 - - HYPH cord-299949-kmn53e2z 129 17 to to IN cord-299949-kmn53e2z 129 18 - - HYPH cord-299949-kmn53e2z 129 19 cell cell NN cord-299949-kmn53e2z 129 20 spread spread NN cord-299949-kmn53e2z 129 21 and and CC cord-299949-kmn53e2z 129 22 eliminate eliminate VB cord-299949-kmn53e2z 129 23 cell cell NN cord-299949-kmn53e2z 129 24 - - HYPH cord-299949-kmn53e2z 129 25 free free JJ cord-299949-kmn53e2z 129 26 infectious infectious JJ cord-299949-kmn53e2z 129 27 virus virus NN cord-299949-kmn53e2z 129 28 ( ( -LRB- cord-299949-kmn53e2z 129 29 Figure figure NN cord-299949-kmn53e2z 129 30 2(b 2(b CD cord-299949-kmn53e2z 129 31 ) ) -RRB- cord-299949-kmn53e2z 129 32 ) ) -RRB- cord-299949-kmn53e2z 129 33 . . . cord-299949-kmn53e2z 130 1 This this DT cord-299949-kmn53e2z 130 2 phase phase NN cord-299949-kmn53e2z 130 3 of of IN cord-299949-kmn53e2z 130 4 viral viral JJ cord-299949-kmn53e2z 130 5 clearance clearance NN cord-299949-kmn53e2z 130 6 can can MD cord-299949-kmn53e2z 130 7 be be VB cord-299949-kmn53e2z 130 8 assessed assess VBN cord-299949-kmn53e2z 130 9 by by IN cord-299949-kmn53e2z 130 10 measurement measurement NN cord-299949-kmn53e2z 130 11 of of IN cord-299949-kmn53e2z 130 12 infectious infectious JJ cord-299949-kmn53e2z 130 13 virus virus NN cord-299949-kmn53e2z 130 14 but but CC cord-299949-kmn53e2z 130 15 , , , cord-299949-kmn53e2z 130 16 as as IN cord-299949-kmn53e2z 130 17 neutralizing neutralize VBG cord-299949-kmn53e2z 130 18 antibody antibody NN cord-299949-kmn53e2z 130 19 is be VBZ cord-299949-kmn53e2z 130 20 produced produce VBN cord-299949-kmn53e2z 130 21 , , , cord-299949-kmn53e2z 130 22 virus virus NN cord-299949-kmn53e2z 130 23 clearance clearance NN cord-299949-kmn53e2z 130 24 is be VBZ cord-299949-kmn53e2z 130 25 best well RBS cord-299949-kmn53e2z 130 26 assessed assess VBN cord-299949-kmn53e2z 130 27 by by IN cord-299949-kmn53e2z 130 28 quantitative quantitative JJ cord-299949-kmn53e2z 130 29 measurement measurement NN cord-299949-kmn53e2z 130 30 of of IN cord-299949-kmn53e2z 130 31 viral viral JJ cord-299949-kmn53e2z 130 32 nucleic nucleic JJ cord-299949-kmn53e2z 130 33 acid acid NN cord-299949-kmn53e2z 130 34 . . . cord-299949-kmn53e2z 131 1 Initially initially RB cord-299949-kmn53e2z 131 2 , , , cord-299949-kmn53e2z 131 3 local local JJ cord-299949-kmn53e2z 131 4 production production NN cord-299949-kmn53e2z 131 5 of of IN cord-299949-kmn53e2z 131 6 type type NN cord-299949-kmn53e2z 131 7 - - : cord-299949-kmn53e2z 131 8 I -PRON- PRP cord-299949-kmn53e2z 131 9 IFN IFN NNP cord-299949-kmn53e2z 131 10 reduces reduce VBZ cord-299949-kmn53e2z 131 11 cell cell NN cord-299949-kmn53e2z 131 12 - - HYPH cord-299949-kmn53e2z 131 13 to to IN cord-299949-kmn53e2z 131 14 - - HYPH cord-299949-kmn53e2z 131 15 cell cell NN cord-299949-kmn53e2z 131 16 spread spread NN cord-299949-kmn53e2z 131 17 through through IN cord-299949-kmn53e2z 131 18 paracrine paracrine JJ cord-299949-kmn53e2z 131 19 antiviral antiviral JJ cord-299949-kmn53e2z 131 20 signaling signaling NN cord-299949-kmn53e2z 131 21 . . . cord-299949-kmn53e2z 132 1 Infectious infectious JJ cord-299949-kmn53e2z 132 2 virus virus NN cord-299949-kmn53e2z 132 3 is be VBZ cord-299949-kmn53e2z 132 4 neutralized neutralize VBN cord-299949-kmn53e2z 132 5 by by IN cord-299949-kmn53e2z 132 6 antibody antibody NN cord-299949-kmn53e2z 132 7 produced produce VBN cord-299949-kmn53e2z 132 8 by by IN cord-299949-kmn53e2z 132 9 B b NN cord-299949-kmn53e2z 132 10 cells cell NNS cord-299949-kmn53e2z 132 11 that that WDT cord-299949-kmn53e2z 132 12 enter enter VBP cord-299949-kmn53e2z 132 13 the the DT cord-299949-kmn53e2z 132 14 CNS CNS NNP cord-299949-kmn53e2z 132 15 and and CC cord-299949-kmn53e2z 132 16 interact interact VB cord-299949-kmn53e2z 132 17 with with IN cord-299949-kmn53e2z 132 18 viral viral JJ cord-299949-kmn53e2z 132 19 glycoproteins glycoprotein NNS cord-299949-kmn53e2z 132 20 on on IN cord-299949-kmn53e2z 132 21 the the DT cord-299949-kmn53e2z 132 22 infected infected JJ cord-299949-kmn53e2z 132 23 cell cell NN cord-299949-kmn53e2z 132 24 surface surface NN cord-299949-kmn53e2z 132 25 . . . cord-299949-kmn53e2z 133 1 Additionally additionally RB cord-299949-kmn53e2z 133 2 , , , cord-299949-kmn53e2z 133 3 IFN IFN NNP cord-299949-kmn53e2z 133 4 - - HYPH cord-299949-kmn53e2z 133 5 g g NNP cord-299949-kmn53e2z 133 6 , , , cord-299949-kmn53e2z 133 7 interacting interact VBG cord-299949-kmn53e2z 133 8 with with IN cord-299949-kmn53e2z 133 9 IFN IFN NNP cord-299949-kmn53e2z 133 10 - - HYPH cord-299949-kmn53e2z 133 11 g g NNP cord-299949-kmn53e2z 133 12 receptors receptor NNS cord-299949-kmn53e2z 133 13 expressed express VBN cord-299949-kmn53e2z 133 14 on on IN cord-299949-kmn53e2z 133 15 the the DT cord-299949-kmn53e2z 133 16 surfaces surface NNS cord-299949-kmn53e2z 133 17 of of IN cord-299949-kmn53e2z 133 18 infected infected JJ cord-299949-kmn53e2z 133 19 cells cell NNS cord-299949-kmn53e2z 133 20 , , , cord-299949-kmn53e2z 133 21 inhibits inhibit VBZ cord-299949-kmn53e2z 133 22 virus virus NN cord-299949-kmn53e2z 133 23 production production NN cord-299949-kmn53e2z 134 1 ( ( -LRB- cord-299949-kmn53e2z 134 2 Phares Phares NNP cord-299949-kmn53e2z 134 3 et et NNP cord-299949-kmn53e2z 134 4 al al NNP cord-299949-kmn53e2z 134 5 . . . cord-299949-kmn53e2z 135 1 , , , cord-299949-kmn53e2z 135 2 2013 2013 CD cord-299949-kmn53e2z 135 3 ; ; : cord-299949-kmn53e2z 135 4 Metcalf Metcalf NNP cord-299949-kmn53e2z 135 5 et et NNP cord-299949-kmn53e2z 135 6 al al NNP cord-299949-kmn53e2z 135 7 . . NNP cord-299949-kmn53e2z 135 8 , , , cord-299949-kmn53e2z 135 9 2013 2013 CD cord-299949-kmn53e2z 135 10 ; ; : cord-299949-kmn53e2z 135 11 Stewart Stewart NNP cord-299949-kmn53e2z 135 12 et et NNP cord-299949-kmn53e2z 135 13 al al NNP cord-299949-kmn53e2z 135 14 . . NNP cord-299949-kmn53e2z 135 15 , , , cord-299949-kmn53e2z 135 16 2011 2011 CD cord-299949-kmn53e2z 135 17 ; ; : cord-299949-kmn53e2z 135 18 Hooper Hooper NNP cord-299949-kmn53e2z 135 19 et et NNP cord-299949-kmn53e2z 135 20 al al NNP cord-299949-kmn53e2z 135 21 . . . cord-299949-kmn53e2z 136 1 , , , cord-299949-kmn53e2z 136 2 2009 2009 CD cord-299949-kmn53e2z 136 3 ; ; : cord-299949-kmn53e2z 136 4 Tschen Tschen NNP cord-299949-kmn53e2z 136 5 et et NNP cord-299949-kmn53e2z 136 6 al al NNP cord-299949-kmn53e2z 136 7 . . NNP cord-299949-kmn53e2z 136 8 , , , cord-299949-kmn53e2z 136 9 2006 2006 CD cord-299949-kmn53e2z 136 10 ; ; . cord-299949-kmn53e2z 137 1 Binder Binder NNP cord-299949-kmn53e2z 137 2 and and CC cord-299949-kmn53e2z 137 3 Griffin Griffin NNP cord-299949-kmn53e2z 137 4 , , , cord-299949-kmn53e2z 137 5 2001 2001 CD cord-299949-kmn53e2z 137 6 ; ; : cord-299949-kmn53e2z 137 7 Ubol Ubol NNP cord-299949-kmn53e2z 137 8 et et NNP cord-299949-kmn53e2z 137 9 al al NNP cord-299949-kmn53e2z 137 10 . . NNP cord-299949-kmn53e2z 137 11 , , , cord-299949-kmn53e2z 137 12 1995 1995 CD cord-299949-kmn53e2z 137 13 ; ; : cord-299949-kmn53e2z 137 14 Levine Levine NNP cord-299949-kmn53e2z 137 15 et et NNP cord-299949-kmn53e2z 137 16 al al NNP cord-299949-kmn53e2z 137 17 . . NNP cord-299949-kmn53e2z 137 18 , , , cord-299949-kmn53e2z 137 19 1991 1991 CD cord-299949-kmn53e2z 137 20 ) ) -RRB- cord-299949-kmn53e2z 137 21 . . . cord-299949-kmn53e2z 138 1 For for IN cord-299949-kmn53e2z 138 2 full full JJ cord-299949-kmn53e2z 138 3 recovery recovery NN cord-299949-kmn53e2z 138 4 , , , cord-299949-kmn53e2z 138 5 virus virus NN cord-299949-kmn53e2z 138 6 - - HYPH cord-299949-kmn53e2z 138 7 infected infect VBN cord-299949-kmn53e2z 138 8 cells cell NNS cord-299949-kmn53e2z 138 9 or or CC cord-299949-kmn53e2z 138 10 viral viral JJ cord-299949-kmn53e2z 138 11 genomes genome NNS cord-299949-kmn53e2z 138 12 need need VBP cord-299949-kmn53e2z 138 13 to to TO cord-299949-kmn53e2z 138 14 be be VB cord-299949-kmn53e2z 138 15 cleared clear VBN cord-299949-kmn53e2z 138 16 from from IN cord-299949-kmn53e2z 138 17 the the DT cord-299949-kmn53e2z 138 18 CNS CNS NNP cord-299949-kmn53e2z 138 19 . . . cord-299949-kmn53e2z 139 1 In in IN cord-299949-kmn53e2z 139 2 peripheral peripheral JJ cord-299949-kmn53e2z 139 3 tissues tissue NNS cord-299949-kmn53e2z 139 4 , , , cord-299949-kmn53e2z 139 5 virus virus NN cord-299949-kmn53e2z 139 6 - - HYPH cord-299949-kmn53e2z 139 7 infected infect VBN cord-299949-kmn53e2z 139 8 cells cell NNS cord-299949-kmn53e2z 139 9 are be VBP cord-299949-kmn53e2z 139 10 usually usually RB cord-299949-kmn53e2z 139 11 eliminated eliminate VBN cord-299949-kmn53e2z 139 12 by by IN cord-299949-kmn53e2z 139 13 virus virus NN cord-299949-kmn53e2z 139 14 - - HYPH cord-299949-kmn53e2z 139 15 induced induce VBN cord-299949-kmn53e2z 139 16 or or CC cord-299949-kmn53e2z 139 17 immunemediated immunemediate VBN cord-299949-kmn53e2z 139 18 cytolysis cytolysis NNP cord-299949-kmn53e2z 139 19 . . . cord-299949-kmn53e2z 140 1 Clearance clearance NN cord-299949-kmn53e2z 140 2 of of IN cord-299949-kmn53e2z 140 3 virus virus NN cord-299949-kmn53e2z 140 4 - - HYPH cord-299949-kmn53e2z 140 5 infected infect VBN cord-299949-kmn53e2z 140 6 cells cell NNS cord-299949-kmn53e2z 140 7 in in IN cord-299949-kmn53e2z 140 8 the the DT cord-299949-kmn53e2z 140 9 CNS CNS NNP cord-299949-kmn53e2z 140 10 becomes become VBZ cord-299949-kmn53e2z 140 11 a a DT cord-299949-kmn53e2z 140 12 more more RBR cord-299949-kmn53e2z 140 13 complicated complicated JJ cord-299949-kmn53e2z 140 14 process process NN cord-299949-kmn53e2z 140 15 due due IN cord-299949-kmn53e2z 140 16 to to IN cord-299949-kmn53e2z 140 17 the the DT cord-299949-kmn53e2z 140 18 nonrenewable nonrenewable JJ cord-299949-kmn53e2z 140 19 and and CC cord-299949-kmn53e2z 140 20 essential essential JJ cord-299949-kmn53e2z 140 21 nature nature NN cord-299949-kmn53e2z 140 22 of of IN cord-299949-kmn53e2z 140 23 neurons neuron NNS cord-299949-kmn53e2z 140 24 and and CC cord-299949-kmn53e2z 140 25 the the DT cord-299949-kmn53e2z 140 26 important important JJ cord-299949-kmn53e2z 140 27 role role NN cord-299949-kmn53e2z 140 28 of of IN cord-299949-kmn53e2z 140 29 glial glial JJ cord-299949-kmn53e2z 140 30 cells cell NNS cord-299949-kmn53e2z 140 31 in in IN cord-299949-kmn53e2z 140 32 maintaining maintain VBG cord-299949-kmn53e2z 140 33 neuronal neuronal JJ cord-299949-kmn53e2z 140 34 function function NN cord-299949-kmn53e2z 140 35 . . . cord-299949-kmn53e2z 141 1 If if IN cord-299949-kmn53e2z 141 2 the the DT cord-299949-kmn53e2z 141 3 immune immune JJ cord-299949-kmn53e2z 141 4 system system NN cord-299949-kmn53e2z 141 5 destroys destroy VBZ cord-299949-kmn53e2z 141 6 the the DT cord-299949-kmn53e2z 141 7 infected infected JJ cord-299949-kmn53e2z 141 8 cell cell NN cord-299949-kmn53e2z 141 9 , , , cord-299949-kmn53e2z 141 10 then then RB cord-299949-kmn53e2z 141 11 the the DT cord-299949-kmn53e2z 141 12 outcome outcome NN cord-299949-kmn53e2z 141 13 of of IN cord-299949-kmn53e2z 141 14 infection infection NN cord-299949-kmn53e2z 141 15 will will MD cord-299949-kmn53e2z 141 16 be be VB cord-299949-kmn53e2z 141 17 the the DT cord-299949-kmn53e2z 141 18 same same JJ cord-299949-kmn53e2z 141 19 as as IN cord-299949-kmn53e2z 141 20 if if IN cord-299949-kmn53e2z 141 21 the the DT cord-299949-kmn53e2z 141 22 virus virus NN cord-299949-kmn53e2z 141 23 caused cause VBD cord-299949-kmn53e2z 141 24 cell cell NN cord-299949-kmn53e2z 141 25 death death NN cord-299949-kmn53e2z 141 26 . . . cord-299949-kmn53e2z 142 1 However however RB cord-299949-kmn53e2z 142 2 , , , cord-299949-kmn53e2z 142 3 if if IN cord-299949-kmn53e2z 142 4 infected infected JJ cord-299949-kmn53e2z 142 5 cells cell NNS cord-299949-kmn53e2z 142 6 are be VBP cord-299949-kmn53e2z 142 7 allowed allow VBN cord-299949-kmn53e2z 142 8 to to TO cord-299949-kmn53e2z 142 9 survive survive VB cord-299949-kmn53e2z 142 10 , , , cord-299949-kmn53e2z 142 11 there there EX cord-299949-kmn53e2z 142 12 must must MD cord-299949-kmn53e2z 142 13 be be VB cord-299949-kmn53e2z 142 14 a a DT cord-299949-kmn53e2z 142 15 clearance clearance NN cord-299949-kmn53e2z 142 16 mechanism mechanism NN cord-299949-kmn53e2z 142 17 that that WDT cord-299949-kmn53e2z 142 18 inhibits inhibit VBZ cord-299949-kmn53e2z 142 19 synthesis synthesis NN cord-299949-kmn53e2z 142 20 of of IN cord-299949-kmn53e2z 142 21 viral viral JJ cord-299949-kmn53e2z 142 22 nucleic nucleic JJ cord-299949-kmn53e2z 142 23 acid acid NN cord-299949-kmn53e2z 142 24 and and CC cord-299949-kmn53e2z 142 25 proteins protein NNS cord-299949-kmn53e2z 142 26 and and CC cord-299949-kmn53e2z 142 27 eliminates eliminate VBZ cord-299949-kmn53e2z 142 28 viral viral JJ cord-299949-kmn53e2z 142 29 genomes genome NNS cord-299949-kmn53e2z 142 30 . . . cord-299949-kmn53e2z 143 1 If if IN cord-299949-kmn53e2z 143 2 clearance clearance NN cord-299949-kmn53e2z 143 3 is be VBZ cord-299949-kmn53e2z 143 4 not not RB cord-299949-kmn53e2z 143 5 complete complete JJ cord-299949-kmn53e2z 143 6 , , , cord-299949-kmn53e2z 143 7 mechanisms mechanism NNS cord-299949-kmn53e2z 143 8 are be VBP cord-299949-kmn53e2z 143 9 needed need VBN cord-299949-kmn53e2z 143 10 to to TO cord-299949-kmn53e2z 143 11 avoid avoid VB cord-299949-kmn53e2z 143 12 progressive progressive JJ cord-299949-kmn53e2z 143 13 or or CC cord-299949-kmn53e2z 143 14 relapsing relapse VBG cord-299949-kmn53e2z 143 15 disease disease NN cord-299949-kmn53e2z 143 16 . . . cord-299949-kmn53e2z 144 1 These these DT cord-299949-kmn53e2z 144 2 processes process NNS cord-299949-kmn53e2z 144 3 must must MD cord-299949-kmn53e2z 144 4 be be VB cord-299949-kmn53e2z 144 5 tightly tightly RB cord-299949-kmn53e2z 144 6 regulated regulate VBN cord-299949-kmn53e2z 144 7 to to TO cord-299949-kmn53e2z 144 8 prevent prevent VB cord-299949-kmn53e2z 144 9 immune immune NN cord-299949-kmn53e2z 144 10 - - HYPH cord-299949-kmn53e2z 144 11 mediated mediate VBN cord-299949-kmn53e2z 144 12 damage damage NN cord-299949-kmn53e2z 144 13 to to IN cord-299949-kmn53e2z 144 14 both both CC cord-299949-kmn53e2z 144 15 infected infected JJ cord-299949-kmn53e2z 144 16 and and CC cord-299949-kmn53e2z 144 17 uninfected uninfected JJ cord-299949-kmn53e2z 144 18 cells cell NNS cord-299949-kmn53e2z 144 19 during during IN cord-299949-kmn53e2z 144 20 the the DT cord-299949-kmn53e2z 144 21 response response NN cord-299949-kmn53e2z 144 22 to to IN cord-299949-kmn53e2z 144 23 CNS CNS NNP cord-299949-kmn53e2z 144 24 infection infection NN cord-299949-kmn53e2z 144 25 . . . cord-299949-kmn53e2z 145 1 For for IN cord-299949-kmn53e2z 145 2 instance instance NN cord-299949-kmn53e2z 145 3 , , , cord-299949-kmn53e2z 145 4 the the DT cord-299949-kmn53e2z 145 5 CD8 CD8 NNP cord-299949-kmn53e2z 145 6 þ þ NNP cord-299949-kmn53e2z 145 7 T T NNP cord-299949-kmn53e2z 145 8 cell cell NN cord-299949-kmn53e2z 145 9 response response NN cord-299949-kmn53e2z 145 10 can can MD cord-299949-kmn53e2z 145 11 be be VB cord-299949-kmn53e2z 145 12 detrimental detrimental JJ cord-299949-kmn53e2z 145 13 during during IN cord-299949-kmn53e2z 145 14 WNV WNV NNP cord-299949-kmn53e2z 145 15 infection infection NN cord-299949-kmn53e2z 146 1 ( ( -LRB- cord-299949-kmn53e2z 146 2 Szretter Szretter NNP cord-299949-kmn53e2z 146 3 et et NNP cord-299949-kmn53e2z 146 4 al al NNP cord-299949-kmn53e2z 146 5 . . NNP cord-299949-kmn53e2z 146 6 , , , cord-299949-kmn53e2z 146 7 2012 2012 CD cord-299949-kmn53e2z 146 8 ; ; : cord-299949-kmn53e2z 146 9 Wang Wang NNP cord-299949-kmn53e2z 146 10 et et NNP cord-299949-kmn53e2z 146 11 al al NNP cord-299949-kmn53e2z 146 12 . . NNP cord-299949-kmn53e2z 146 13 , , , cord-299949-kmn53e2z 146 14 2003 2003 CD cord-299949-kmn53e2z 146 15 ) ) -RRB- cord-299949-kmn53e2z 146 16 . . . cord-299949-kmn53e2z 147 1 During during IN cord-299949-kmn53e2z 147 2 fatal fatal JJ cord-299949-kmn53e2z 147 3 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 147 4 due due IN cord-299949-kmn53e2z 147 5 to to IN cord-299949-kmn53e2z 147 6 infection infection NN cord-299949-kmn53e2z 147 7 with with IN cord-299949-kmn53e2z 147 8 a a DT cord-299949-kmn53e2z 147 9 neurovirulent neurovirulent NN cord-299949-kmn53e2z 147 10 strain strain NN cord-299949-kmn53e2z 147 11 of of IN cord-299949-kmn53e2z 147 12 the the DT cord-299949-kmn53e2z 147 13 alphavirus alphavirus NNP cord-299949-kmn53e2z 147 14 SINV SINV NNP cord-299949-kmn53e2z 147 15 , , , cord-299949-kmn53e2z 147 16 infiltration infiltration NN cord-299949-kmn53e2z 147 17 of of IN cord-299949-kmn53e2z 147 18 Th1 th1 NN cord-299949-kmn53e2z 147 19 and and CC cord-299949-kmn53e2z 147 20 Th1/ Th1/ NNP cord-299949-kmn53e2z 148 1 Th17 Th17 NNP cord-299949-kmn53e2z 149 1 CD4 CD4 NNP cord-299949-kmn53e2z 149 2 þ þ NNP cord-299949-kmn53e2z 149 3 T t NN cord-299949-kmn53e2z 149 4 cells cell NNS cord-299949-kmn53e2z 149 5 is be VBZ cord-299949-kmn53e2z 149 6 associated associate VBN cord-299949-kmn53e2z 149 7 with with IN cord-299949-kmn53e2z 149 8 a a DT cord-299949-kmn53e2z 149 9 rapidly rapidly RB cord-299949-kmn53e2z 149 10 fatal fatal JJ cord-299949-kmn53e2z 149 11 paralytic paralytic JJ cord-299949-kmn53e2z 149 12 disease disease NN cord-299949-kmn53e2z 149 13 . . . cord-299949-kmn53e2z 150 1 This this DT cord-299949-kmn53e2z 150 2 response response NN cord-299949-kmn53e2z 150 3 is be VBZ cord-299949-kmn53e2z 150 4 modulated modulate VBN cord-299949-kmn53e2z 150 5 by by IN cord-299949-kmn53e2z 150 6 IL-10 IL-10 NNP cord-299949-kmn53e2z 150 7 produced produce VBN cord-299949-kmn53e2z 150 8 by by IN cord-299949-kmn53e2z 150 9 intrinsic intrinsic JJ cord-299949-kmn53e2z 150 10 cells cell NNS cord-299949-kmn53e2z 150 11 of of IN cord-299949-kmn53e2z 150 12 the the DT cord-299949-kmn53e2z 150 13 CNS CNS NNP cord-299949-kmn53e2z 150 14 and and CC cord-299949-kmn53e2z 150 15 by by IN cord-299949-kmn53e2z 150 16 infiltrating infiltrate VBG cord-299949-kmn53e2z 150 17 regulatory regulatory JJ cord-299949-kmn53e2z 150 18 T t NN cord-299949-kmn53e2z 150 19 cells cell NNS cord-299949-kmn53e2z 150 20 ( ( -LRB- cord-299949-kmn53e2z 150 21 Kulcsar Kulcsar NNP cord-299949-kmn53e2z 150 22 et et FW cord-299949-kmn53e2z 150 23 al al NNP cord-299949-kmn53e2z 150 24 . . . cord-299949-kmn53e2z 151 1 , , , cord-299949-kmn53e2z 151 2 2014 2014 CD cord-299949-kmn53e2z 151 3 ) ) -RRB- cord-299949-kmn53e2z 151 4 . . . cord-299949-kmn53e2z 152 1 IL-10 IL-10 NNP cord-299949-kmn53e2z 152 2 also also RB cord-299949-kmn53e2z 152 3 plays play VBZ cord-299949-kmn53e2z 152 4 a a DT cord-299949-kmn53e2z 152 5 protective protective JJ cord-299949-kmn53e2z 152 6 role role NN cord-299949-kmn53e2z 152 7 during during IN cord-299949-kmn53e2z 152 8 coronavirus coronavirus NN cord-299949-kmn53e2z 152 9 and and CC cord-299949-kmn53e2z 152 10 flavivirus flavivirus JJ cord-299949-kmn53e2z 152 11 infections infection NNS cord-299949-kmn53e2z 152 12 of of IN cord-299949-kmn53e2z 152 13 the the DT cord-299949-kmn53e2z 152 14 CNS CNS NNP cord-299949-kmn53e2z 152 15 ( ( -LRB- cord-299949-kmn53e2z 152 16 Tun Tun NNP cord-299949-kmn53e2z 152 17 et et FW cord-299949-kmn53e2z 152 18 al al NNP cord-299949-kmn53e2z 152 19 . . NNP cord-299949-kmn53e2z 152 20 , , , cord-299949-kmn53e2z 152 21 2014 2014 CD cord-299949-kmn53e2z 152 22 ; ; : cord-299949-kmn53e2z 152 23 Hayasaka Hayasaka NNP cord-299949-kmn53e2z 152 24 et et NNP cord-299949-kmn53e2z 152 25 al al NNP cord-299949-kmn53e2z 152 26 . . NNP cord-299949-kmn53e2z 152 27 , , , cord-299949-kmn53e2z 152 28 2013 2013 CD cord-299949-kmn53e2z 152 29 ; ; : cord-299949-kmn53e2z 152 30 Trandem Trandem NNP cord-299949-kmn53e2z 152 31 et et FW cord-299949-kmn53e2z 152 32 al al NNP cord-299949-kmn53e2z 152 33 . . NNP cord-299949-kmn53e2z 152 34 , , , cord-299949-kmn53e2z 152 35 2011 2011 CD cord-299949-kmn53e2z 152 36 ) ) -RRB- cord-299949-kmn53e2z 152 37 . . . cord-299949-kmn53e2z 153 1 Generally generally RB cord-299949-kmn53e2z 153 2 , , , cord-299949-kmn53e2z 153 3 clearance clearance NN cord-299949-kmn53e2z 153 4 of of IN cord-299949-kmn53e2z 153 5 RNA RNA NNP cord-299949-kmn53e2z 153 6 viruses virus NNS cord-299949-kmn53e2z 153 7 from from IN cord-299949-kmn53e2z 153 8 neurons neuron NNS cord-299949-kmn53e2z 153 9 occurs occur VBZ cord-299949-kmn53e2z 153 10 through through IN cord-299949-kmn53e2z 153 11 noncytolytic noncytolytic JJ cord-299949-kmn53e2z 153 12 antibody antibody NN cord-299949-kmn53e2z 153 13 and and CC cord-299949-kmn53e2z 153 14 cytokine cytokine NN cord-299949-kmn53e2z 153 15 - - HYPH cord-299949-kmn53e2z 153 16 mediated mediate VBN cord-299949-kmn53e2z 153 17 mechanisms mechanism NNS cord-299949-kmn53e2z 153 18 to to TO cord-299949-kmn53e2z 153 19 preserve preserve VB cord-299949-kmn53e2z 153 20 neuronal neuronal JJ cord-299949-kmn53e2z 153 21 function function NN cord-299949-kmn53e2z 153 22 . . . cord-299949-kmn53e2z 154 1 This this DT cord-299949-kmn53e2z 154 2 process process NN cord-299949-kmn53e2z 154 3 has have VBZ cord-299949-kmn53e2z 154 4 been be VBN cord-299949-kmn53e2z 154 5 studied study VBN cord-299949-kmn53e2z 154 6 both both CC cord-299949-kmn53e2z 154 7 in in IN cord-299949-kmn53e2z 154 8 virus virus NN cord-299949-kmn53e2z 154 9 - - HYPH cord-299949-kmn53e2z 154 10 infected infect VBN cord-299949-kmn53e2z 154 11 mice mouse NNS cord-299949-kmn53e2z 154 12 and and CC cord-299949-kmn53e2z 154 13 in in IN cord-299949-kmn53e2z 154 14 cultured cultured JJ cord-299949-kmn53e2z 154 15 neurons neuron NNS cord-299949-kmn53e2z 154 16 . . . cord-299949-kmn53e2z 155 1 In in IN cord-299949-kmn53e2z 155 2 mice mouse NNS cord-299949-kmn53e2z 155 3 , , , cord-299949-kmn53e2z 155 4 the the DT cord-299949-kmn53e2z 155 5 clearance clearance NN cord-299949-kmn53e2z 155 6 of of IN cord-299949-kmn53e2z 155 7 SINV SINV NNP cord-299949-kmn53e2z 155 8 is be VBZ cord-299949-kmn53e2z 155 9 a a DT cord-299949-kmn53e2z 155 10 two two CD cord-299949-kmn53e2z 155 11 - - HYPH cord-299949-kmn53e2z 155 12 phase phase NN cord-299949-kmn53e2z 155 13 process process NN cord-299949-kmn53e2z 155 14 ( ( -LRB- cord-299949-kmn53e2z 155 15 Metcalf Metcalf NNP cord-299949-kmn53e2z 155 16 and and CC cord-299949-kmn53e2z 155 17 Griffin Griffin NNP cord-299949-kmn53e2z 155 18 , , , cord-299949-kmn53e2z 155 19 2011 2011 CD cord-299949-kmn53e2z 155 20 ) ) -RRB- cord-299949-kmn53e2z 155 21 . . . cord-299949-kmn53e2z 156 1 Infectious infectious JJ cord-299949-kmn53e2z 156 2 virus virus NN cord-299949-kmn53e2z 156 3 is be VBZ cord-299949-kmn53e2z 156 4 rapidly rapidly RB cord-299949-kmn53e2z 156 5 cleared clear VBN cord-299949-kmn53e2z 156 6 during during IN cord-299949-kmn53e2z 156 7 the the DT cord-299949-kmn53e2z 156 8 first first JJ cord-299949-kmn53e2z 156 9 week week NN cord-299949-kmn53e2z 156 10 after after IN cord-299949-kmn53e2z 156 11 infection infection NN cord-299949-kmn53e2z 156 12 and and CC cord-299949-kmn53e2z 156 13 then then RB cord-299949-kmn53e2z 156 14 viral viral JJ cord-299949-kmn53e2z 156 15 RNA RNA NNP cord-299949-kmn53e2z 156 16 is be VBZ cord-299949-kmn53e2z 156 17 cleared clear VBN cord-299949-kmn53e2z 156 18 slowly slowly RB cord-299949-kmn53e2z 156 19 over over IN cord-299949-kmn53e2z 156 20 the the DT cord-299949-kmn53e2z 156 21 next next JJ cord-299949-kmn53e2z 156 22 30 30 CD cord-299949-kmn53e2z 156 23 - - SYM cord-299949-kmn53e2z 156 24 60 60 CD cord-299949-kmn53e2z 156 25 days day NNS cord-299949-kmn53e2z 156 26 followed follow VBN cord-299949-kmn53e2z 156 27 by by IN cord-299949-kmn53e2z 156 28 persistence persistence NN cord-299949-kmn53e2z 156 29 of of IN cord-299949-kmn53e2z 156 30 a a DT cord-299949-kmn53e2z 156 31 low low JJ cord-299949-kmn53e2z 156 32 level level NN cord-299949-kmn53e2z 156 33 of of IN cord-299949-kmn53e2z 156 34 RNA RNA NNP cord-299949-kmn53e2z 156 35 . . . cord-299949-kmn53e2z 157 1 CD8 CD8 NNP cord-299949-kmn53e2z 157 2 þ þ NNP cord-299949-kmn53e2z 157 3 T T NNP cord-299949-kmn53e2z 157 4 cells cell NNS cord-299949-kmn53e2z 157 5 followed follow VBN cord-299949-kmn53e2z 157 6 by by IN cord-299949-kmn53e2z 157 7 CD4 CD4 NNP cord-299949-kmn53e2z 157 8 þ þ NNP cord-299949-kmn53e2z 157 9 T T NNP cord-299949-kmn53e2z 157 10 cells cell NNS cord-299949-kmn53e2z 157 11 and and CC cord-299949-kmn53e2z 157 12 B b NN cord-299949-kmn53e2z 157 13 cells cell NNS cord-299949-kmn53e2z 157 14 enter enter VBP cord-299949-kmn53e2z 157 15 the the DT cord-299949-kmn53e2z 157 16 CNS CNS NNP cord-299949-kmn53e2z 157 17 during during IN cord-299949-kmn53e2z 157 18 the the DT cord-299949-kmn53e2z 157 19 first first JJ cord-299949-kmn53e2z 157 20 phase phase NN cord-299949-kmn53e2z 157 21 when when WRB cord-299949-kmn53e2z 157 22 infectious infectious JJ cord-299949-kmn53e2z 157 23 virus virus NN cord-299949-kmn53e2z 157 24 is be VBZ cord-299949-kmn53e2z 157 25 cleared clear VBN cord-299949-kmn53e2z 157 26 . . . cord-299949-kmn53e2z 158 1 In in IN cord-299949-kmn53e2z 158 2 the the DT cord-299949-kmn53e2z 158 3 second second JJ cord-299949-kmn53e2z 158 4 phase phase NN cord-299949-kmn53e2z 158 5 , , , cord-299949-kmn53e2z 158 6 T t NN cord-299949-kmn53e2z 158 7 cell cell NN cord-299949-kmn53e2z 158 8 and and CC cord-299949-kmn53e2z 158 9 B b NN cord-299949-kmn53e2z 158 10 cell cell NN cord-299949-kmn53e2z 158 11 are be VBP cord-299949-kmn53e2z 158 12 retained retain VBN cord-299949-kmn53e2z 158 13 in in IN cord-299949-kmn53e2z 158 14 the the DT cord-299949-kmn53e2z 158 15 CNS CNS NNP cord-299949-kmn53e2z 158 16 during during IN cord-299949-kmn53e2z 158 17 viral viral JJ cord-299949-kmn53e2z 158 18 RNA RNA NNP cord-299949-kmn53e2z 158 19 clearance clearance NN cord-299949-kmn53e2z 158 20 with with IN cord-299949-kmn53e2z 158 21 overall overall JJ cord-299949-kmn53e2z 158 22 larger large JJR cord-299949-kmn53e2z 158 23 numbers number NNS cord-299949-kmn53e2z 158 24 of of IN cord-299949-kmn53e2z 158 25 CD4 CD4 NNP cord-299949-kmn53e2z 158 26 þ þ NNP cord-299949-kmn53e2z 158 27 T T NNP cord-299949-kmn53e2z 158 28 cells cell NNS cord-299949-kmn53e2z 158 29 and and CC cord-299949-kmn53e2z 158 30 B b NN cord-299949-kmn53e2z 158 31 cells cell NNS cord-299949-kmn53e2z 158 32 than than IN cord-299949-kmn53e2z 158 33 CD8 CD8 NNP cord-299949-kmn53e2z 158 34 þ þ NNP cord-299949-kmn53e2z 158 35 T T NNP cord-299949-kmn53e2z 158 36 cells cell NNS cord-299949-kmn53e2z 158 37 . . . cord-299949-kmn53e2z 159 1 Numbers number NNS cord-299949-kmn53e2z 159 2 of of IN cord-299949-kmn53e2z 159 3 immune immune JJ cord-299949-kmn53e2z 159 4 cells cell NNS cord-299949-kmn53e2z 159 5 in in IN cord-299949-kmn53e2z 159 6 the the DT cord-299949-kmn53e2z 159 7 CNS CNS NNP cord-299949-kmn53e2z 159 8 gradually gradually RB cord-299949-kmn53e2z 159 9 decrease decrease VBP cord-299949-kmn53e2z 159 10 with with IN cord-299949-kmn53e2z 159 11 decreasing decrease VBG cord-299949-kmn53e2z 159 12 RNA RNA NNP cord-299949-kmn53e2z 159 13 , , , cord-299949-kmn53e2z 159 14 but but CC cord-299949-kmn53e2z 159 15 the the DT cord-299949-kmn53e2z 159 16 resident resident JJ cord-299949-kmn53e2z 159 17 populations population NNS cord-299949-kmn53e2z 159 18 are be VBP cord-299949-kmn53e2z 159 19 steadily steadily RB cord-299949-kmn53e2z 159 20 enriched enrich VBN cord-299949-kmn53e2z 159 21 in in IN cord-299949-kmn53e2z 159 22 those those DT cord-299949-kmn53e2z 159 23 that that WDT cord-299949-kmn53e2z 159 24 are be VBP cord-299949-kmn53e2z 159 25 virus virus NN cord-299949-kmn53e2z 159 26 specific specific JJ cord-299949-kmn53e2z 159 27 . . . cord-299949-kmn53e2z 160 1 Within within IN cord-299949-kmn53e2z 160 2 2 2 CD cord-299949-kmn53e2z 160 3 months month NNS cord-299949-kmn53e2z 160 4 after after IN cord-299949-kmn53e2z 160 5 SINV SINV NNP cord-299949-kmn53e2z 160 6 infection infection NN cord-299949-kmn53e2z 160 7 , , , cord-299949-kmn53e2z 160 8 most most JJS cord-299949-kmn53e2z 160 9 antibody antibody NN cord-299949-kmn53e2z 160 10 - - HYPH cord-299949-kmn53e2z 160 11 secreting secrete VBG cord-299949-kmn53e2z 160 12 cells cell NNS cord-299949-kmn53e2z 160 13 ( ( -LRB- cord-299949-kmn53e2z 160 14 ASCs asc NNS cord-299949-kmn53e2z 160 15 ) ) -RRB- cord-299949-kmn53e2z 160 16 produce produce VBP cord-299949-kmn53e2z 160 17 SINVspecific sinvspecific NN cord-299949-kmn53e2z 160 18 IgG IgG NNP cord-299949-kmn53e2z 160 19 ( ( -LRB- cord-299949-kmn53e2z 160 20 Metcalf Metcalf NNP cord-299949-kmn53e2z 160 21 and and CC cord-299949-kmn53e2z 160 22 Griffin Griffin NNP cord-299949-kmn53e2z 160 23 , , , cord-299949-kmn53e2z 160 24 2011 2011 CD cord-299949-kmn53e2z 160 25 ; ; : cord-299949-kmn53e2z 161 1 Tyor Tyor NNP cord-299949-kmn53e2z 161 2 et et NNP cord-299949-kmn53e2z 161 3 al al NNP cord-299949-kmn53e2z 161 4 . . NNP cord-299949-kmn53e2z 161 5 , , , cord-299949-kmn53e2z 161 6 1992 1992 CD cord-299949-kmn53e2z 161 7 ) ) -RRB- cord-299949-kmn53e2z 161 8 . . . cord-299949-kmn53e2z 162 1 Antibody antibody NN cord-299949-kmn53e2z 162 2 that that WDT cord-299949-kmn53e2z 162 3 mediates mediate VBZ cord-299949-kmn53e2z 162 4 virus virus NN cord-299949-kmn53e2z 162 5 clearance clearance NN cord-299949-kmn53e2z 162 6 from from IN cord-299949-kmn53e2z 162 7 neurons neuron NNS cord-299949-kmn53e2z 162 8 is be VBZ cord-299949-kmn53e2z 162 9 often often RB cord-299949-kmn53e2z 162 10 directed direct VBN cord-299949-kmn53e2z 162 11 against against IN cord-299949-kmn53e2z 162 12 viral viral JJ cord-299949-kmn53e2z 162 13 structural structural JJ cord-299949-kmn53e2z 162 14 proteins protein NNS cord-299949-kmn53e2z 162 15 on on IN cord-299949-kmn53e2z 162 16 the the DT cord-299949-kmn53e2z 162 17 infected infected JJ cord-299949-kmn53e2z 162 18 cell cell NN cord-299949-kmn53e2z 162 19 surface surface NN cord-299949-kmn53e2z 162 20 and and CC cord-299949-kmn53e2z 162 21 has have VBZ cord-299949-kmn53e2z 162 22 been be VBN cord-299949-kmn53e2z 162 23 most most RBS cord-299949-kmn53e2z 162 24 completely completely RB cord-299949-kmn53e2z 162 25 analyzed analyze VBN cord-299949-kmn53e2z 162 26 for for IN cord-299949-kmn53e2z 162 27 cells cell NNS cord-299949-kmn53e2z 162 28 infected infect VBN cord-299949-kmn53e2z 162 29 with with IN cord-299949-kmn53e2z 162 30 SINV SINV NNP cord-299949-kmn53e2z 163 1 ( ( -LRB- cord-299949-kmn53e2z 163 2 Hooper Hooper NNP cord-299949-kmn53e2z 163 3 et et NNP cord-299949-kmn53e2z 163 4 al al NNP cord-299949-kmn53e2z 163 5 . . . cord-299949-kmn53e2z 164 1 , , , cord-299949-kmn53e2z 164 2 2009 2009 CD cord-299949-kmn53e2z 164 3 ; ; : cord-299949-kmn53e2z 164 4 Levine Levine NNP cord-299949-kmn53e2z 164 5 et et NNP cord-299949-kmn53e2z 164 6 al al NNP cord-299949-kmn53e2z 164 7 . . NNP cord-299949-kmn53e2z 164 8 , , , cord-299949-kmn53e2z 164 9 1991 1991 CD cord-299949-kmn53e2z 164 10 ) ) -RRB- cord-299949-kmn53e2z 164 11 . . . cord-299949-kmn53e2z 165 1 In in IN cord-299949-kmn53e2z 165 2 addition addition NN cord-299949-kmn53e2z 165 3 to to IN cord-299949-kmn53e2z 165 4 neutralizing neutralize VBG cord-299949-kmn53e2z 165 5 free free JJ cord-299949-kmn53e2z 165 6 virus virus NN cord-299949-kmn53e2z 165 7 , , , cord-299949-kmn53e2z 165 8 antibody antibody NN cord-299949-kmn53e2z 165 9 to to IN cord-299949-kmn53e2z 165 10 the the DT cord-299949-kmn53e2z 165 11 SINV SINV NNP cord-299949-kmn53e2z 165 12 E2 E2 NNP cord-299949-kmn53e2z 165 13 glycoprotein glycoprotein NN cord-299949-kmn53e2z 165 14 can can MD cord-299949-kmn53e2z 165 15 bind bind VB cord-299949-kmn53e2z 165 16 to to IN cord-299949-kmn53e2z 165 17 the the DT cord-299949-kmn53e2z 165 18 surface surface NN cord-299949-kmn53e2z 165 19 of of IN cord-299949-kmn53e2z 165 20 infected infected JJ cord-299949-kmn53e2z 165 21 cells cell NNS cord-299949-kmn53e2z 165 22 and and CC cord-299949-kmn53e2z 165 23 may may MD cord-299949-kmn53e2z 165 24 direct direct VB cord-299949-kmn53e2z 165 25 intracellular intracellular JJ cord-299949-kmn53e2z 165 26 signaling signaling NN cord-299949-kmn53e2z 165 27 to to IN cord-299949-kmn53e2z 165 28 control control VB cord-299949-kmn53e2z 165 29 virus virus NN cord-299949-kmn53e2z 165 30 replication replication NN cord-299949-kmn53e2z 165 31 ( ( -LRB- cord-299949-kmn53e2z 166 1 Després Després NNP cord-299949-kmn53e2z 166 2 et et FW cord-299949-kmn53e2z 166 3 al al NNP cord-299949-kmn53e2z 166 4 . . . cord-299949-kmn53e2z 167 1 , , , cord-299949-kmn53e2z 167 2 1995b 1995b CD cord-299949-kmn53e2z 167 3 ; ; : cord-299949-kmn53e2z 167 4 Levine Levine NNP cord-299949-kmn53e2z 167 5 and and CC cord-299949-kmn53e2z 167 6 Griffin Griffin NNP cord-299949-kmn53e2z 167 7 , , , cord-299949-kmn53e2z 167 8 1992 1992 CD cord-299949-kmn53e2z 167 9 ) ) -RRB- cord-299949-kmn53e2z 167 10 . . . cord-299949-kmn53e2z 168 1 The the DT cord-299949-kmn53e2z 168 2 antiviral antiviral JJ cord-299949-kmn53e2z 168 3 effect effect NN cord-299949-kmn53e2z 168 4 of of IN cord-299949-kmn53e2z 168 5 this this DT cord-299949-kmn53e2z 168 6 antibody antibody NN cord-299949-kmn53e2z 168 7 does do VBZ cord-299949-kmn53e2z 168 8 not not RB cord-299949-kmn53e2z 168 9 require require VB cord-299949-kmn53e2z 168 10 complement complement NN cord-299949-kmn53e2z 168 11 or or CC cord-299949-kmn53e2z 168 12 phagocytic phagocytic JJ cord-299949-kmn53e2z 168 13 cells cell NNS cord-299949-kmn53e2z 168 14 , , , cord-299949-kmn53e2z 168 15 but but CC cord-299949-kmn53e2z 168 16 is be VBZ cord-299949-kmn53e2z 168 17 dependent dependent JJ cord-299949-kmn53e2z 168 18 on on IN cord-299949-kmn53e2z 168 19 bivalent bivalent JJ cord-299949-kmn53e2z 168 20 antibody antibody NN cord-299949-kmn53e2z 168 21 , , , cord-299949-kmn53e2z 168 22 implying imply VBG cord-299949-kmn53e2z 168 23 that that IN cord-299949-kmn53e2z 168 24 cross cross NN cord-299949-kmn53e2z 168 25 - - NN cord-299949-kmn53e2z 168 26 linking linking NN cord-299949-kmn53e2z 168 27 of of IN cord-299949-kmn53e2z 168 28 viral viral JJ cord-299949-kmn53e2z 168 29 proteins protein NNS cord-299949-kmn53e2z 168 30 at at IN cord-299949-kmn53e2z 168 31 the the DT cord-299949-kmn53e2z 168 32 cell cell NN cord-299949-kmn53e2z 168 33 surface surface NN cord-299949-kmn53e2z 168 34 results result NNS cord-299949-kmn53e2z 168 35 in in IN cord-299949-kmn53e2z 168 36 intracellular intracellular JJ cord-299949-kmn53e2z 168 37 inhibition inhibition NN cord-299949-kmn53e2z 168 38 of of IN cord-299949-kmn53e2z 168 39 virus virus NN cord-299949-kmn53e2z 168 40 production production NN cord-299949-kmn53e2z 169 1 ( ( -LRB- cord-299949-kmn53e2z 169 2 Ubol Ubol NNP cord-299949-kmn53e2z 169 3 et et NNP cord-299949-kmn53e2z 169 4 al al NNP cord-299949-kmn53e2z 169 5 . . . cord-299949-kmn53e2z 170 1 , , , cord-299949-kmn53e2z 170 2 1995 1995 CD cord-299949-kmn53e2z 170 3 ; ; : cord-299949-kmn53e2z 170 4 Levine Levine NNP cord-299949-kmn53e2z 170 5 et et NNP cord-299949-kmn53e2z 170 6 al al NNP cord-299949-kmn53e2z 170 7 . . NNP cord-299949-kmn53e2z 170 8 , , , cord-299949-kmn53e2z 170 9 1991 1991 CD cord-299949-kmn53e2z 170 10 ) ) -RRB- cord-299949-kmn53e2z 170 11 . . . cord-299949-kmn53e2z 171 1 Antibody antibody NN cord-299949-kmn53e2z 171 2 acts act NNS cord-299949-kmn53e2z 171 3 by by IN cord-299949-kmn53e2z 171 4 unknown unknown JJ cord-299949-kmn53e2z 171 5 mechanisms mechanism NNS cord-299949-kmn53e2z 171 6 to to TO cord-299949-kmn53e2z 171 7 suppress suppress VB cord-299949-kmn53e2z 171 8 virus virus NN cord-299949-kmn53e2z 171 9 replication replication NN cord-299949-kmn53e2z 171 10 and and CC cord-299949-kmn53e2z 171 11 restore restore VB cord-299949-kmn53e2z 171 12 host host NN cord-299949-kmn53e2z 171 13 protein protein NN cord-299949-kmn53e2z 171 14 synthesis synthesis NN cord-299949-kmn53e2z 171 15 , , , cord-299949-kmn53e2z 171 16 membrane membrane NN cord-299949-kmn53e2z 171 17 potential potential NN cord-299949-kmn53e2z 171 18 , , , cord-299949-kmn53e2z 171 19 and and CC cord-299949-kmn53e2z 171 20 type type NN cord-299949-kmn53e2z 172 1 -I -I NFP cord-299949-kmn53e2z 172 2 IFN IFN NNP cord-299949-kmn53e2z 172 3 responsiveness responsiveness NN cord-299949-kmn53e2z 173 1 ( ( -LRB- cord-299949-kmn53e2z 173 2 Després Després NNP cord-299949-kmn53e2z 173 3 et et FW cord-299949-kmn53e2z 173 4 al al NNP cord-299949-kmn53e2z 173 5 . . NNP cord-299949-kmn53e2z 173 6 , , , cord-299949-kmn53e2z 173 7 1995a 1995a CD cord-299949-kmn53e2z 173 8 , , , cord-299949-kmn53e2z 173 9 b b LS cord-299949-kmn53e2z 173 10 ) ) -RRB- cord-299949-kmn53e2z 173 11 . . . cord-299949-kmn53e2z 174 1 CD8 CD8 NNP cord-299949-kmn53e2z 174 2 þ þ NNP cord-299949-kmn53e2z 174 3 T T NNP cord-299949-kmn53e2z 174 4 cells cell NNS cord-299949-kmn53e2z 174 5 can can MD cord-299949-kmn53e2z 174 6 exert exert VB cord-299949-kmn53e2z 174 7 antiviral antiviral JJ cord-299949-kmn53e2z 174 8 effector effector NN cord-299949-kmn53e2z 174 9 functions function NNS cord-299949-kmn53e2z 174 10 either either CC cord-299949-kmn53e2z 174 11 through through IN cord-299949-kmn53e2z 174 12 a a DT cord-299949-kmn53e2z 174 13 noncytotoxic noncytotoxic NN cord-299949-kmn53e2z 174 14 , , , cord-299949-kmn53e2z 174 15 cytokine cytokine NN cord-299949-kmn53e2z 174 16 - - HYPH cord-299949-kmn53e2z 174 17 mediated mediate VBN cord-299949-kmn53e2z 174 18 , , , cord-299949-kmn53e2z 174 19 or or CC cord-299949-kmn53e2z 174 20 a a DT cord-299949-kmn53e2z 174 21 cytotoxic cytotoxic JJ cord-299949-kmn53e2z 174 22 pathway pathway NN cord-299949-kmn53e2z 174 23 . . . cord-299949-kmn53e2z 175 1 The the DT cord-299949-kmn53e2z 175 2 most most RBS cord-299949-kmn53e2z 175 3 effective effective JJ cord-299949-kmn53e2z 175 4 noncytotoxic noncytotoxic NN cord-299949-kmn53e2z 175 5 cytokine cytokine NN cord-299949-kmn53e2z 175 6 identified identify VBN cord-299949-kmn53e2z 175 7 is be VBZ cord-299949-kmn53e2z 175 8 IFN IFN NNP cord-299949-kmn53e2z 175 9 - - HYPH cord-299949-kmn53e2z 175 10 g g NNP cord-299949-kmn53e2z 175 11 and and CC cord-299949-kmn53e2z 176 1 the the DT cord-299949-kmn53e2z 176 2 cytotoxic cytotoxic JJ cord-299949-kmn53e2z 176 3 effector effector NN cord-299949-kmn53e2z 176 4 pathways pathway NNS cord-299949-kmn53e2z 176 5 involve involve VBP cord-299949-kmn53e2z 176 6 perforin perforin NNP cord-299949-kmn53e2z 176 7 and and CC cord-299949-kmn53e2z 176 8 granzymes granzyme NNS cord-299949-kmn53e2z 176 9 or or CC cord-299949-kmn53e2z 176 10 CD95 CD95 NNP cord-299949-kmn53e2z 176 11 ( ( -LRB- cord-299949-kmn53e2z 176 12 Fas)-CD95L fas)-cd95l CD cord-299949-kmn53e2z 176 13 interaction interaction NN cord-299949-kmn53e2z 176 14 . . . cord-299949-kmn53e2z 177 1 CD8 CD8 NNP cord-299949-kmn53e2z 177 2 þ þ NNP cord-299949-kmn53e2z 177 3 T T NNP cord-299949-kmn53e2z 177 4 cells cell NNS cord-299949-kmn53e2z 177 5 can can MD cord-299949-kmn53e2z 177 6 be be VB cord-299949-kmn53e2z 177 7 activated activate VBN cord-299949-kmn53e2z 177 8 by by IN cord-299949-kmn53e2z 177 9 interactions interaction NNS cord-299949-kmn53e2z 177 10 with with IN cord-299949-kmn53e2z 177 11 MHC MHC NNP cord-299949-kmn53e2z 177 12 class class NN cord-299949-kmn53e2z 178 1 I -PRON- PRP cord-299949-kmn53e2z 178 2 complexes complex NNS cord-299949-kmn53e2z 178 3 on on IN cord-299949-kmn53e2z 178 4 neurons neuron NNS cord-299949-kmn53e2z 179 1 ( ( -LRB- cord-299949-kmn53e2z 179 2 Chevalier Chevalier NNP cord-299949-kmn53e2z 179 3 et et NNP cord-299949-kmn53e2z 179 4 al al NNP cord-299949-kmn53e2z 179 5 . . NNP cord-299949-kmn53e2z 179 6 , , , cord-299949-kmn53e2z 179 7 2011 2011 CD cord-299949-kmn53e2z 179 8 ) ) -RRB- cord-299949-kmn53e2z 179 9 or or CC cord-299949-kmn53e2z 179 10 through through IN cord-299949-kmn53e2z 179 11 cross cross JJ cord-299949-kmn53e2z 179 12 - - JJ cord-299949-kmn53e2z 179 13 priming priming JJ cord-299949-kmn53e2z 179 14 interactions interaction NNS cord-299949-kmn53e2z 179 15 with with IN cord-299949-kmn53e2z 179 16 MHC MHC NNP cord-299949-kmn53e2z 179 17 class class NN cord-299949-kmn53e2z 180 1 I -PRON- PRP cord-299949-kmn53e2z 180 2 molecules molecule VBZ cord-299949-kmn53e2z 180 3 on on IN cord-299949-kmn53e2z 180 4 surrounding surround VBG cord-299949-kmn53e2z 180 5 glial glial JJ cord-299949-kmn53e2z 180 6 cells cell NNS cord-299949-kmn53e2z 180 7 . . . cord-299949-kmn53e2z 181 1 T t NN cord-299949-kmn53e2z 181 2 cells cell NNS cord-299949-kmn53e2z 181 3 recruited recruit VBN cord-299949-kmn53e2z 181 4 into into IN cord-299949-kmn53e2z 181 5 the the DT cord-299949-kmn53e2z 181 6 CNS CNS NNP cord-299949-kmn53e2z 181 7 during during IN cord-299949-kmn53e2z 181 8 SINV SINV NNP cord-299949-kmn53e2z 181 9 infection infection NN cord-299949-kmn53e2z 181 10 facilitate facilitate VBP cord-299949-kmn53e2z 181 11 , , , cord-299949-kmn53e2z 181 12 but but CC cord-299949-kmn53e2z 181 13 are be VBP cord-299949-kmn53e2z 181 14 not not RB cord-299949-kmn53e2z 181 15 necessary necessary JJ cord-299949-kmn53e2z 181 16 , , , cord-299949-kmn53e2z 181 17 for for IN cord-299949-kmn53e2z 181 18 RNA RNA NNP cord-299949-kmn53e2z 181 19 clearance clearance NN cord-299949-kmn53e2z 182 1 ( ( -LRB- cord-299949-kmn53e2z 182 2 Rowell Rowell NNP cord-299949-kmn53e2z 182 3 and and CC cord-299949-kmn53e2z 182 4 Griffin Griffin NNP cord-299949-kmn53e2z 182 5 , , , cord-299949-kmn53e2z 182 6 2002 2002 CD cord-299949-kmn53e2z 182 7 ; ; : cord-299949-kmn53e2z 182 8 Kimura Kimura NNP cord-299949-kmn53e2z 182 9 and and CC cord-299949-kmn53e2z 182 10 Griffin Griffin NNP cord-299949-kmn53e2z 182 11 , , , cord-299949-kmn53e2z 182 12 2000 2000 CD cord-299949-kmn53e2z 182 13 ) ) -RRB- cord-299949-kmn53e2z 182 14 . . . cord-299949-kmn53e2z 183 1 IFN IFN NNP cord-299949-kmn53e2z 183 2 - - HYPH cord-299949-kmn53e2z 183 3 g g NNP cord-299949-kmn53e2z 183 4 alone alone RB cord-299949-kmn53e2z 183 5 can can MD cord-299949-kmn53e2z 183 6 clear clear VB cord-299949-kmn53e2z 183 7 SINV SINV NNP cord-299949-kmn53e2z 183 8 from from IN cord-299949-kmn53e2z 183 9 motor motor NN cord-299949-kmn53e2z 183 10 neurons neuron NNS cord-299949-kmn53e2z 183 11 , , , cord-299949-kmn53e2z 183 12 but but CC cord-299949-kmn53e2z 183 13 not not RB cord-299949-kmn53e2z 183 14 from from IN cord-299949-kmn53e2z 183 15 cortical cortical JJ cord-299949-kmn53e2z 183 16 or or CC cord-299949-kmn53e2z 183 17 hippocampal hippocampal JJ cord-299949-kmn53e2z 183 18 neurons neuron NNS cord-299949-kmn53e2z 183 19 which which WDT cord-299949-kmn53e2z 183 20 require require VBP cord-299949-kmn53e2z 183 21 antibody antibody NN cord-299949-kmn53e2z 183 22 ( ( -LRB- cord-299949-kmn53e2z 183 23 Burdeinick Burdeinick NNP cord-299949-kmn53e2z 183 24 - - HYPH cord-299949-kmn53e2z 183 25 Kerr Kerr NNP cord-299949-kmn53e2z 183 26 and and CC cord-299949-kmn53e2z 183 27 Griffin Griffin NNP cord-299949-kmn53e2z 183 28 , , , cord-299949-kmn53e2z 183 29 2005 2005 CD cord-299949-kmn53e2z 183 30 ; ; : cord-299949-kmn53e2z 183 31 Binder Binder NNP cord-299949-kmn53e2z 183 32 and and CC cord-299949-kmn53e2z 183 33 Griffin Griffin NNP cord-299949-kmn53e2z 183 34 , , , cord-299949-kmn53e2z 183 35 2001 2001 CD cord-299949-kmn53e2z 183 36 ) ) -RRB- cord-299949-kmn53e2z 183 37 . . . cord-299949-kmn53e2z 184 1 IFN IFN NNP cord-299949-kmn53e2z 184 2 - - HYPH cord-299949-kmn53e2z 184 3 g g NN cord-299949-kmn53e2z 184 4 production production NN cord-299949-kmn53e2z 184 5 by by IN cord-299949-kmn53e2z 184 6 T t NN cord-299949-kmn53e2z 184 7 cells cell NNS cord-299949-kmn53e2z 184 8 is be VBZ cord-299949-kmn53e2z 184 9 also also RB cord-299949-kmn53e2z 184 10 important important JJ cord-299949-kmn53e2z 184 11 for for IN cord-299949-kmn53e2z 184 12 clearance clearance NN cord-299949-kmn53e2z 184 13 of of IN cord-299949-kmn53e2z 184 14 MHV MHV NNP cord-299949-kmn53e2z 184 15 , , , cord-299949-kmn53e2z 184 16 Borna Borna NNP cord-299949-kmn53e2z 184 17 disease disease NN cord-299949-kmn53e2z 184 18 virus virus NN cord-299949-kmn53e2z 184 19 , , , cord-299949-kmn53e2z 184 20 and and CC cord-299949-kmn53e2z 184 21 measles measles NN cord-299949-kmn53e2z 184 22 virus virus NN cord-299949-kmn53e2z 184 23 infections infection NNS cord-299949-kmn53e2z 184 24 from from IN cord-299949-kmn53e2z 184 25 the the DT cord-299949-kmn53e2z 184 26 CNS CNS NNP cord-299949-kmn53e2z 185 1 ( ( -LRB- cord-299949-kmn53e2z 185 2 O'Donnell O'Donnell NNP cord-299949-kmn53e2z 185 3 et et NNP cord-299949-kmn53e2z 185 4 al al NNP cord-299949-kmn53e2z 185 5 . . NNP cord-299949-kmn53e2z 185 6 , , , cord-299949-kmn53e2z 185 7 2012 2012 CD cord-299949-kmn53e2z 185 8 ; ; : cord-299949-kmn53e2z 185 9 Stubblefield Stubblefield NNP cord-299949-kmn53e2z 185 10 Park Park NNP cord-299949-kmn53e2z 185 11 et et NNP cord-299949-kmn53e2z 185 12 al al NNP cord-299949-kmn53e2z 185 13 . . NNP cord-299949-kmn53e2z 185 14 , , , cord-299949-kmn53e2z 185 15 2011 2011 CD cord-299949-kmn53e2z 185 16 ; ; : cord-299949-kmn53e2z 185 17 Richter Richter NNP cord-299949-kmn53e2z 185 18 et et NNP cord-299949-kmn53e2z 185 19 al al NNP cord-299949-kmn53e2z 185 20 . . NNP cord-299949-kmn53e2z 185 21 , , , cord-299949-kmn53e2z 185 22 2009 2009 CD cord-299949-kmn53e2z 185 23 ; ; . cord-299949-kmn53e2z 186 1 Templeton Templeton NNP cord-299949-kmn53e2z 186 2 and and CC cord-299949-kmn53e2z 186 3 Perlman Perlman NNP cord-299949-kmn53e2z 186 4 , , , cord-299949-kmn53e2z 186 5 2008 2008 CD cord-299949-kmn53e2z 186 6 ; ; : cord-299949-kmn53e2z 186 7 Pearce Pearce NNP cord-299949-kmn53e2z 186 8 et et NNP cord-299949-kmn53e2z 186 9 al al NNP cord-299949-kmn53e2z 186 10 . . NNP cord-299949-kmn53e2z 186 11 , , , cord-299949-kmn53e2z 186 12 1994 1994 CD cord-299949-kmn53e2z 186 13 ) ) -RRB- cord-299949-kmn53e2z 186 14 . . . cord-299949-kmn53e2z 187 1 Clearance clearance NN cord-299949-kmn53e2z 187 2 of of IN cord-299949-kmn53e2z 187 3 WNV WNV NNP cord-299949-kmn53e2z 187 4 is be VBZ cord-299949-kmn53e2z 187 5 dependent dependent JJ cord-299949-kmn53e2z 187 6 on on IN cord-299949-kmn53e2z 187 7 CD8 CD8 NNP cord-299949-kmn53e2z 187 8 þ þ NNP cord-299949-kmn53e2z 187 9 T T NNP cord-299949-kmn53e2z 187 10 cells cell NNS cord-299949-kmn53e2z 187 11 and and CC cord-299949-kmn53e2z 187 12 monocytes monocyte NNS cord-299949-kmn53e2z 187 13 , , , cord-299949-kmn53e2z 187 14 not not RB cord-299949-kmn53e2z 187 15 antibody antibody NN cord-299949-kmn53e2z 187 16 ( ( -LRB- cord-299949-kmn53e2z 187 17 Sitati Sitati NNP cord-299949-kmn53e2z 187 18 et et NNP cord-299949-kmn53e2z 187 19 al al NNP cord-299949-kmn53e2z 187 20 . . NNP cord-299949-kmn53e2z 187 21 , , , cord-299949-kmn53e2z 187 22 2007 2007 CD cord-299949-kmn53e2z 187 23 ; ; : cord-299949-kmn53e2z 187 24 Shrestha Shrestha NNP cord-299949-kmn53e2z 187 25 et et NNP cord-299949-kmn53e2z 187 26 al al NNP cord-299949-kmn53e2z 187 27 . . NNP cord-299949-kmn53e2z 187 28 , , , cord-299949-kmn53e2z 187 29 2006 2006 CD cord-299949-kmn53e2z 187 30 ; ; . cord-299949-kmn53e2z 188 1 Klein Klein NNP cord-299949-kmn53e2z 188 2 et et NNP cord-299949-kmn53e2z 188 3 al al NNP cord-299949-kmn53e2z 188 4 . . NNP cord-299949-kmn53e2z 188 5 , , , cord-299949-kmn53e2z 188 6 2005 2005 CD cord-299949-kmn53e2z 188 7 ) ) -RRB- cord-299949-kmn53e2z 188 8 . . . cord-299949-kmn53e2z 189 1 Monocyte Monocyte NNP cord-299949-kmn53e2z 189 2 - - HYPH cord-299949-kmn53e2z 189 3 derived derive VBN cord-299949-kmn53e2z 189 4 cells cell NNS cord-299949-kmn53e2z 189 5 likely likely RB cord-299949-kmn53e2z 189 6 signal signal NN cord-299949-kmn53e2z 189 7 to to IN cord-299949-kmn53e2z 189 8 T t NN cord-299949-kmn53e2z 189 9 cells cell NNS cord-299949-kmn53e2z 189 10 , , , cord-299949-kmn53e2z 189 11 leading lead VBG cord-299949-kmn53e2z 189 12 to to IN cord-299949-kmn53e2z 189 13 optimal optimal JJ cord-299949-kmn53e2z 189 14 activation activation NN cord-299949-kmn53e2z 189 15 necessary necessary JJ cord-299949-kmn53e2z 189 16 for for IN cord-299949-kmn53e2z 189 17 virus virus NN cord-299949-kmn53e2z 189 18 clearance clearance NN cord-299949-kmn53e2z 189 19 ( ( -LRB- cord-299949-kmn53e2z 189 20 Durrant Durrant NNP cord-299949-kmn53e2z 189 21 et et NNP cord-299949-kmn53e2z 189 22 al al NNP cord-299949-kmn53e2z 189 23 . . NNP cord-299949-kmn53e2z 189 24 , , , cord-299949-kmn53e2z 189 25 2013 2013 CD cord-299949-kmn53e2z 189 26 ) ) -RRB- cord-299949-kmn53e2z 189 27 . . . cord-299949-kmn53e2z 190 1 T t NN cord-299949-kmn53e2z 190 2 cells cell NNS cord-299949-kmn53e2z 190 3 clear clear JJ cord-299949-kmn53e2z 190 4 virus virus NN cord-299949-kmn53e2z 190 5 through through IN cord-299949-kmn53e2z 190 6 IFN IFN NNP cord-299949-kmn53e2z 190 7 - - HYPH cord-299949-kmn53e2z 190 8 g g NN cord-299949-kmn53e2z 190 9 production production NN cord-299949-kmn53e2z 190 10 or or CC cord-299949-kmn53e2z 190 11 through through IN cord-299949-kmn53e2z 190 12 cytotoxic cytotoxic JJ cord-299949-kmn53e2z 190 13 methods method NNS cord-299949-kmn53e2z 190 14 , , , cord-299949-kmn53e2z 190 15 such such JJ cord-299949-kmn53e2z 190 16 as as IN cord-299949-kmn53e2z 190 17 perforin perforin NNP cord-299949-kmn53e2z 190 18 ( ( -LRB- cord-299949-kmn53e2z 190 19 Shrestha Shrestha NNP cord-299949-kmn53e2z 190 20 et et FW cord-299949-kmn53e2z 190 21 al al NNP cord-299949-kmn53e2z 190 22 . . NNP cord-299949-kmn53e2z 190 23 , , , cord-299949-kmn53e2z 190 24 2006 2006 CD cord-299949-kmn53e2z 190 25 ) ) -RRB- cord-299949-kmn53e2z 190 26 . . . cord-299949-kmn53e2z 191 1 Cytotoxic Cytotoxic NNP cord-299949-kmn53e2z 191 2 T t NN cord-299949-kmn53e2z 191 3 cells cell NNS cord-299949-kmn53e2z 191 4 are be VBP cord-299949-kmn53e2z 191 5 targeted target VBN cord-299949-kmn53e2z 191 6 to to IN cord-299949-kmn53e2z 191 7 infected infected JJ cord-299949-kmn53e2z 191 8 neurons neuron NNS cord-299949-kmn53e2z 191 9 upon upon IN cord-299949-kmn53e2z 191 10 upregulation upregulation NN cord-299949-kmn53e2z 191 11 of of IN cord-299949-kmn53e2z 191 12 prodeath prodeath JJ cord-299949-kmn53e2z 191 13 molecules molecule NNS cord-299949-kmn53e2z 191 14 ( ( -LRB- cord-299949-kmn53e2z 191 15 Fas Fas NNP cord-299949-kmn53e2z 191 16 or or CC cord-299949-kmn53e2z 191 17 TRAIL TRAIL NNP cord-299949-kmn53e2z 191 18 ligand ligand NN cord-299949-kmn53e2z 191 19 ) ) -RRB- cord-299949-kmn53e2z 191 20 and and CC cord-299949-kmn53e2z 191 21 increased increase VBD cord-299949-kmn53e2z 191 22 MHC MHC NNP cord-299949-kmn53e2z 191 23 class class NN cord-299949-kmn53e2z 191 24 I -PRON- PRP cord-299949-kmn53e2z 191 25 expression expression NN cord-299949-kmn53e2z 191 26 ( ( -LRB- cord-299949-kmn53e2z 191 27 Shrestha Shrestha NNP cord-299949-kmn53e2z 191 28 et et FW cord-299949-kmn53e2z 191 29 al al NNP cord-299949-kmn53e2z 191 30 . . NNP cord-299949-kmn53e2z 191 31 , , , cord-299949-kmn53e2z 191 32 2012 2012 CD cord-299949-kmn53e2z 191 33 ; ; : cord-299949-kmn53e2z 191 34 Chevalier Chevalier NNP cord-299949-kmn53e2z 191 35 et et NNP cord-299949-kmn53e2z 191 36 al al NNP cord-299949-kmn53e2z 191 37 . . NNP cord-299949-kmn53e2z 191 38 , , , cord-299949-kmn53e2z 191 39 2011 2011 CD cord-299949-kmn53e2z 191 40 ; ; : cord-299949-kmn53e2z 191 41 Shrestha Shrestha NNP cord-299949-kmn53e2z 191 42 and and CC cord-299949-kmn53e2z 191 43 Diamond Diamond NNP cord-299949-kmn53e2z 191 44 , , , cord-299949-kmn53e2z 191 45 2007 2007 CD cord-299949-kmn53e2z 191 46 ) ) -RRB- cord-299949-kmn53e2z 191 47 . . . cord-299949-kmn53e2z 192 1 Neurons neuron NNS cord-299949-kmn53e2z 192 2 infected infect VBN cord-299949-kmn53e2z 192 3 with with IN cord-299949-kmn53e2z 192 4 virulent virulent JJ cord-299949-kmn53e2z 192 5 strains strain NNS cord-299949-kmn53e2z 192 6 of of IN cord-299949-kmn53e2z 192 7 rabies rabies NN cord-299949-kmn53e2z 192 8 virus virus NN cord-299949-kmn53e2z 192 9 upregulate upregulate VBD cord-299949-kmn53e2z 192 10 FasL FasL NNP cord-299949-kmn53e2z 192 11 and and CC cord-299949-kmn53e2z 192 12 B7-H1 B7-H1 NNP cord-299949-kmn53e2z 192 13 to to TO cord-299949-kmn53e2z 192 14 inhibit inhibit VB cord-299949-kmn53e2z 192 15 T t NN cord-299949-kmn53e2z 192 16 cell cell NN cord-299949-kmn53e2z 192 17 function function NN cord-299949-kmn53e2z 192 18 and and CC cord-299949-kmn53e2z 192 19 prevent prevent VBP cord-299949-kmn53e2z 192 20 virus virus NN cord-299949-kmn53e2z 192 21 clearance clearance NN cord-299949-kmn53e2z 192 22 and and CC cord-299949-kmn53e2z 192 23 the the DT cord-299949-kmn53e2z 192 24 virus virus NN cord-299949-kmn53e2z 192 25 - - HYPH cord-299949-kmn53e2z 192 26 induced induce VBN cord-299949-kmn53e2z 192 27 inflammatory inflammatory JJ cord-299949-kmn53e2z 192 28 response response NN cord-299949-kmn53e2z 192 29 ( ( -LRB- cord-299949-kmn53e2z 192 30 Lafon Lafon NNP cord-299949-kmn53e2z 192 31 et et FW cord-299949-kmn53e2z 192 32 al al NNP cord-299949-kmn53e2z 192 33 . . NNP cord-299949-kmn53e2z 192 34 , , , cord-299949-kmn53e2z 192 35 2008 2008 CD cord-299949-kmn53e2z 192 36 ; ; . cord-299949-kmn53e2z 193 1 Baloul Baloul NNP cord-299949-kmn53e2z 193 2 et et NNP cord-299949-kmn53e2z 193 3 al al NNP cord-299949-kmn53e2z 193 4 . . NNP cord-299949-kmn53e2z 193 5 , , , cord-299949-kmn53e2z 193 6 2004 2004 CD cord-299949-kmn53e2z 193 7 ) ) -RRB- cord-299949-kmn53e2z 193 8 . . . cord-299949-kmn53e2z 194 1 Additional additional JJ cord-299949-kmn53e2z 194 2 upregulation upregulation NN cord-299949-kmn53e2z 194 3 of of IN cord-299949-kmn53e2z 194 4 the the DT cord-299949-kmn53e2z 194 5 nonclassical nonclassical JJ cord-299949-kmn53e2z 194 6 MHC MHC NNP cord-299949-kmn53e2z 194 7 class class NN cord-299949-kmn53e2z 194 8 I -PRON- PRP cord-299949-kmn53e2z 194 9 molecule molecule VBP cord-299949-kmn53e2z 194 10 HLA HLA NNP cord-299949-kmn53e2z 194 11 - - HYPH cord-299949-kmn53e2z 194 12 G G NNP cord-299949-kmn53e2z 194 13 on on IN cord-299949-kmn53e2z 194 14 infected infected JJ cord-299949-kmn53e2z 194 15 neurons neuron NNS cord-299949-kmn53e2z 194 16 may may MD cord-299949-kmn53e2z 194 17 promote promote VB cord-299949-kmn53e2z 194 18 tolerance tolerance NN cord-299949-kmn53e2z 194 19 . . . cord-299949-kmn53e2z 195 1 The the DT cord-299949-kmn53e2z 195 2 best well RBS cord-299949-kmn53e2z 195 3 - - HYPH cord-299949-kmn53e2z 195 4 studied study VBN cord-299949-kmn53e2z 195 5 examples example NNS cord-299949-kmn53e2z 195 6 of of IN cord-299949-kmn53e2z 195 7 glial glial JJ cord-299949-kmn53e2z 195 8 cell cell NN cord-299949-kmn53e2z 195 9 infections infection NNS cord-299949-kmn53e2z 195 10 in in IN cord-299949-kmn53e2z 195 11 mice mouse NNS cord-299949-kmn53e2z 195 12 are be VBP cord-299949-kmn53e2z 195 13 the the DT cord-299949-kmn53e2z 195 14 picornavirus picornavirus NN cord-299949-kmn53e2z 195 15 TMEV TMEV NNP cord-299949-kmn53e2z 195 16 and and CC cord-299949-kmn53e2z 195 17 coronavirus coronavirus NN cord-299949-kmn53e2z 195 18 MHV mhv NN cord-299949-kmn53e2z 195 19 . . . cord-299949-kmn53e2z 196 1 Failure failure NN cord-299949-kmn53e2z 196 2 to to TO cord-299949-kmn53e2z 196 3 clear clear VB cord-299949-kmn53e2z 196 4 the the DT cord-299949-kmn53e2z 196 5 acute acute JJ cord-299949-kmn53e2z 196 6 infection infection NN cord-299949-kmn53e2z 196 7 by by IN cord-299949-kmn53e2z 196 8 susceptible susceptible JJ cord-299949-kmn53e2z 196 9 strains strain NNS cord-299949-kmn53e2z 196 10 of of IN cord-299949-kmn53e2z 196 11 mice mouse NNS cord-299949-kmn53e2z 196 12 leads lead VBZ cord-299949-kmn53e2z 196 13 to to IN cord-299949-kmn53e2z 196 14 persistent persistent JJ cord-299949-kmn53e2z 196 15 production production NN cord-299949-kmn53e2z 196 16 of of IN cord-299949-kmn53e2z 196 17 infectious infectious JJ cord-299949-kmn53e2z 196 18 virus virus NN cord-299949-kmn53e2z 196 19 and and CC cord-299949-kmn53e2z 196 20 immune immune NN cord-299949-kmn53e2z 196 21 - - HYPH cord-299949-kmn53e2z 196 22 mediated mediate VBN cord-299949-kmn53e2z 196 23 demyelinating demyelinating NN cord-299949-kmn53e2z 196 24 disease disease NN cord-299949-kmn53e2z 196 25 . . . cord-299949-kmn53e2z 197 1 Thus thus RB cord-299949-kmn53e2z 197 2 , , , cord-299949-kmn53e2z 197 3 these these DT cord-299949-kmn53e2z 197 4 infections infection NNS cord-299949-kmn53e2z 197 5 have have VBP cord-299949-kmn53e2z 197 6 become become VBN cord-299949-kmn53e2z 197 7 models model NNS cord-299949-kmn53e2z 197 8 for for IN cord-299949-kmn53e2z 197 9 the the DT cord-299949-kmn53e2z 197 10 human human JJ cord-299949-kmn53e2z 197 11 demyelinating demyelinate VBG cord-299949-kmn53e2z 197 12 disease disease NN cord-299949-kmn53e2z 197 13 multiple multiple JJ cord-299949-kmn53e2z 197 14 sclerosis sclerosis NN cord-299949-kmn53e2z 197 15 . . . cord-299949-kmn53e2z 198 1 TMEV TMEV NNP cord-299949-kmn53e2z 198 2 has have VBZ cord-299949-kmn53e2z 198 3 an an DT cord-299949-kmn53e2z 198 4 early early JJ cord-299949-kmn53e2z 198 5 encephalitic encephalitic JJ cord-299949-kmn53e2z 198 6 phase phase NN cord-299949-kmn53e2z 198 7 , , , cord-299949-kmn53e2z 198 8 which which WDT cord-299949-kmn53e2z 198 9 mainly mainly RB cord-299949-kmn53e2z 198 10 involves involve VBZ cord-299949-kmn53e2z 198 11 infection infection NN cord-299949-kmn53e2z 198 12 of of IN cord-299949-kmn53e2z 198 13 neurons neuron NNS cord-299949-kmn53e2z 198 14 , , , cord-299949-kmn53e2z 198 15 followed follow VBN cord-299949-kmn53e2z 198 16 by by IN cord-299949-kmn53e2z 198 17 persistent persistent JJ cord-299949-kmn53e2z 198 18 infection infection NN cord-299949-kmn53e2z 198 19 of of IN cord-299949-kmn53e2z 198 20 glial glial JJ cord-299949-kmn53e2z 198 21 cells cell NNS cord-299949-kmn53e2z 198 22 . . . cord-299949-kmn53e2z 199 1 In in IN cord-299949-kmn53e2z 199 2 resistant resistant JJ cord-299949-kmn53e2z 199 3 strains strain NNS cord-299949-kmn53e2z 199 4 of of IN cord-299949-kmn53e2z 199 5 mice mouse NNS cord-299949-kmn53e2z 199 6 , , , cord-299949-kmn53e2z 199 7 virus virus NN cord-299949-kmn53e2z 199 8 clearance clearance NN cord-299949-kmn53e2z 199 9 is be VBZ cord-299949-kmn53e2z 199 10 dependent dependent JJ cord-299949-kmn53e2z 199 11 on on IN cord-299949-kmn53e2z 199 12 a a DT cord-299949-kmn53e2z 199 13 rapid rapid JJ cord-299949-kmn53e2z 199 14 CD8 CD8 NNP cord-299949-kmn53e2z 199 15 þ þ NNP cord-299949-kmn53e2z 199 16 T T NNP cord-299949-kmn53e2z 199 17 cell cell NN cord-299949-kmn53e2z 199 18 response response NN cord-299949-kmn53e2z 199 19 ( ( -LRB- cord-299949-kmn53e2z 199 20 Lindsley Lindsley NNP cord-299949-kmn53e2z 199 21 and and CC cord-299949-kmn53e2z 199 22 Rodriguez Rodriguez NNP cord-299949-kmn53e2z 199 23 , , , cord-299949-kmn53e2z 199 24 1989 1989 CD cord-299949-kmn53e2z 199 25 ) ) -RRB- cord-299949-kmn53e2z 199 26 . . . cord-299949-kmn53e2z 200 1 In in IN cord-299949-kmn53e2z 200 2 susceptible susceptible JJ cord-299949-kmn53e2z 200 3 strains strain NNS cord-299949-kmn53e2z 200 4 , , , cord-299949-kmn53e2z 200 5 infectious infectious JJ cord-299949-kmn53e2z 200 6 virus virus NN cord-299949-kmn53e2z 200 7 is be VBZ cord-299949-kmn53e2z 200 8 cleared clear VBN cord-299949-kmn53e2z 200 9 from from IN cord-299949-kmn53e2z 200 10 the the DT cord-299949-kmn53e2z 200 11 neurons neuron NNS cord-299949-kmn53e2z 200 12 , , , cord-299949-kmn53e2z 200 13 but but CC cord-299949-kmn53e2z 200 14 not not RB cord-299949-kmn53e2z 200 15 from from IN cord-299949-kmn53e2z 200 16 microglia microglia NNS cord-299949-kmn53e2z 200 17 , , , cord-299949-kmn53e2z 200 18 astrocytes astrocyte NNS cord-299949-kmn53e2z 200 19 , , , cord-299949-kmn53e2z 200 20 or or CC cord-299949-kmn53e2z 200 21 oligodendrocytes oligodendrocyte NNS cord-299949-kmn53e2z 200 22 . . . cord-299949-kmn53e2z 201 1 Establishment establishment NN cord-299949-kmn53e2z 201 2 of of IN cord-299949-kmn53e2z 201 3 a a DT cord-299949-kmn53e2z 201 4 persistent persistent JJ cord-299949-kmn53e2z 201 5 infection infection NN cord-299949-kmn53e2z 201 6 involves involve VBZ cord-299949-kmn53e2z 201 7 failure failure NN cord-299949-kmn53e2z 201 8 of of IN cord-299949-kmn53e2z 201 9 all all DT cord-299949-kmn53e2z 201 10 stages stage NNS cord-299949-kmn53e2z 201 11 of of IN cord-299949-kmn53e2z 201 12 the the DT cord-299949-kmn53e2z 201 13 immune immune JJ cord-299949-kmn53e2z 201 14 response response NN cord-299949-kmn53e2z 201 15 , , , cord-299949-kmn53e2z 201 16 beginning begin VBG cord-299949-kmn53e2z 201 17 with with IN cord-299949-kmn53e2z 201 18 innate innate JJ cord-299949-kmn53e2z 201 19 immune immune NN cord-299949-kmn53e2z 201 20 signaling signal VBG cord-299949-kmn53e2z 201 21 through through IN cord-299949-kmn53e2z 201 22 TLR3 TLR3 NNP cord-299949-kmn53e2z 201 23 and and CC cord-299949-kmn53e2z 201 24 TLR2 TLR2 NNP cord-299949-kmn53e2z 201 25 , , , cord-299949-kmn53e2z 201 26 proinflammatory proinflammatory JJ cord-299949-kmn53e2z 201 27 molecule molecule NN cord-299949-kmn53e2z 201 28 expression expression NN cord-299949-kmn53e2z 201 29 ( ( -LRB- cord-299949-kmn53e2z 201 30 IL-6 IL-6 NNP cord-299949-kmn53e2z 201 31 ) ) -RRB- cord-299949-kmn53e2z 201 32 , , , cord-299949-kmn53e2z 201 33 and and CC cord-299949-kmn53e2z 201 34 regulation regulation NN cord-299949-kmn53e2z 201 35 of of IN cord-299949-kmn53e2z 201 36 infiltrating infiltrate VBG cord-299949-kmn53e2z 201 37 T t NN cord-299949-kmn53e2z 201 38 cells cell NNS cord-299949-kmn53e2z 201 39 ( ( -LRB- cord-299949-kmn53e2z 201 40 Jin Jin NNP cord-299949-kmn53e2z 201 41 et et NNP cord-299949-kmn53e2z 201 42 al al NNP cord-299949-kmn53e2z 201 43 . . NNP cord-299949-kmn53e2z 201 44 , , , cord-299949-kmn53e2z 201 45 2010 2010 CD cord-299949-kmn53e2z 201 46 ; ; . cord-299949-kmn53e2z 202 1 So so RB cord-299949-kmn53e2z 202 2 and and CC cord-299949-kmn53e2z 202 3 Kim Kim NNP cord-299949-kmn53e2z 202 4 , , , cord-299949-kmn53e2z 202 5 2009 2009 CD cord-299949-kmn53e2z 202 6 ) ) -RRB- cord-299949-kmn53e2z 202 7 . . . cord-299949-kmn53e2z 203 1 IL-6 IL-6 NNP cord-299949-kmn53e2z 203 2 inhibits inhibit VBZ cord-299949-kmn53e2z 203 3 cytotoxic cytotoxic JJ cord-299949-kmn53e2z 203 4 T t NN cord-299949-kmn53e2z 203 5 cell cell NN cord-299949-kmn53e2z 203 6 function function NN cord-299949-kmn53e2z 203 7 and and CC cord-299949-kmn53e2z 203 8 apoptotic apoptotic JJ cord-299949-kmn53e2z 203 9 death death NN cord-299949-kmn53e2z 203 10 by by IN cord-299949-kmn53e2z 203 11 preferential preferential JJ cord-299949-kmn53e2z 203 12 induction induction NN cord-299949-kmn53e2z 203 13 of of IN cord-299949-kmn53e2z 203 14 IL-17-producing IL-17-producing NNP cord-299949-kmn53e2z 203 15 Th17 Th17 NNP cord-299949-kmn53e2z 203 16 cells cell NNS cord-299949-kmn53e2z 203 17 ( ( -LRB- cord-299949-kmn53e2z 203 18 Hou Hou NNP cord-299949-kmn53e2z 203 19 et et NNP cord-299949-kmn53e2z 203 20 al al NNP cord-299949-kmn53e2z 203 21 . . NNP cord-299949-kmn53e2z 203 22 , , , cord-299949-kmn53e2z 203 23 2009 2009 CD cord-299949-kmn53e2z 203 24 ) ) -RRB- cord-299949-kmn53e2z 203 25 . . . cord-299949-kmn53e2z 204 1 Additionally additionally RB cord-299949-kmn53e2z 204 2 , , , cord-299949-kmn53e2z 204 3 IL-17 IL-17 NNP cord-299949-kmn53e2z 204 4 and and CC cord-299949-kmn53e2z 204 5 IL-6 IL-6 NNP cord-299949-kmn53e2z 204 6 synergistically synergistically RB cord-299949-kmn53e2z 204 7 promote promote VBP cord-299949-kmn53e2z 204 8 expression expression NN cord-299949-kmn53e2z 204 9 of of IN cord-299949-kmn53e2z 204 10 prosurvival prosurvival NNP cord-299949-kmn53e2z 204 11 Bcl Bcl NNP cord-299949-kmn53e2z 204 12 family family NN cord-299949-kmn53e2z 204 13 members member NNS cord-299949-kmn53e2z 204 14 that that WDT cord-299949-kmn53e2z 204 15 facilitate facilitate VBP cord-299949-kmn53e2z 204 16 survival survival NN cord-299949-kmn53e2z 204 17 of of IN cord-299949-kmn53e2z 204 18 virus virus NN cord-299949-kmn53e2z 204 19 - - HYPH cord-299949-kmn53e2z 204 20 infected infect VBN cord-299949-kmn53e2z 204 21 cells cell NNS cord-299949-kmn53e2z 204 22 ( ( -LRB- cord-299949-kmn53e2z 204 23 Hou Hou NNP cord-299949-kmn53e2z 204 24 et et FW cord-299949-kmn53e2z 204 25 al al NNP cord-299949-kmn53e2z 204 26 . . NNP cord-299949-kmn53e2z 204 27 , , , cord-299949-kmn53e2z 204 28 2014 2014 CD cord-299949-kmn53e2z 204 29 ) ) -RRB- cord-299949-kmn53e2z 204 30 . . . cord-299949-kmn53e2z 205 1 MHV MHV NNP cord-299949-kmn53e2z 205 2 infects infect VBZ cord-299949-kmn53e2z 205 3 a a DT cord-299949-kmn53e2z 205 4 wide wide JJ cord-299949-kmn53e2z 205 5 range range NN cord-299949-kmn53e2z 205 6 of of IN cord-299949-kmn53e2z 205 7 cell cell NN cord-299949-kmn53e2z 205 8 types type NNS cord-299949-kmn53e2z 205 9 including include VBG cord-299949-kmn53e2z 205 10 macrophages macrophage NNS cord-299949-kmn53e2z 205 11 , , , cord-299949-kmn53e2z 205 12 microglia microglia NNS cord-299949-kmn53e2z 205 13 , , , cord-299949-kmn53e2z 205 14 astrocytes astrocyte NNS cord-299949-kmn53e2z 205 15 , , , cord-299949-kmn53e2z 205 16 and and CC cord-299949-kmn53e2z 205 17 oligodendrocytes oligodendrocyte NNS cord-299949-kmn53e2z 205 18 . . . cord-299949-kmn53e2z 206 1 The the DT cord-299949-kmn53e2z 206 2 early early JJ cord-299949-kmn53e2z 206 3 adaptive adaptive JJ cord-299949-kmn53e2z 206 4 response response NN cord-299949-kmn53e2z 206 5 to to IN cord-299949-kmn53e2z 206 6 MHV MHV NNP cord-299949-kmn53e2z 206 7 infection infection NN cord-299949-kmn53e2z 206 8 is be VBZ cord-299949-kmn53e2z 206 9 characterized characterize VBN cord-299949-kmn53e2z 206 10 by by IN cord-299949-kmn53e2z 206 11 expression expression NN cord-299949-kmn53e2z 206 12 of of IN cord-299949-kmn53e2z 206 13 the the DT cord-299949-kmn53e2z 206 14 chemokines chemokine NNS cord-299949-kmn53e2z 206 15 CXCL9 CXCL9 NNP cord-299949-kmn53e2z 206 16 , , , cord-299949-kmn53e2z 206 17 CXCL10 CXCL10 NNP cord-299949-kmn53e2z 206 18 , , , cord-299949-kmn53e2z 206 19 CCL2 CCL2 NNP cord-299949-kmn53e2z 206 20 , , , cord-299949-kmn53e2z 206 21 CCL3 CCL3 NNP cord-299949-kmn53e2z 206 22 , , , cord-299949-kmn53e2z 206 23 and and CC cord-299949-kmn53e2z 206 24 CCL5 CCL5 NNP cord-299949-kmn53e2z 206 25 and and CC cord-299949-kmn53e2z 206 26 their -PRON- PRP$ cord-299949-kmn53e2z 206 27 receptors receptor NNS cord-299949-kmn53e2z 206 28 CCR1 CCR1 NNP cord-299949-kmn53e2z 206 29 , , , cord-299949-kmn53e2z 206 30 CCR5 CCR5 NNP cord-299949-kmn53e2z 206 31 , , , cord-299949-kmn53e2z 206 32 and and CC cord-299949-kmn53e2z 206 33 CXCR3 CXCR3 VBN cord-299949-kmn53e2z 206 34 by by IN cord-299949-kmn53e2z 206 35 microglia microglia NNS cord-299949-kmn53e2z 206 36 and and CC cord-299949-kmn53e2z 206 37 astrocytes astrocyte NNS cord-299949-kmn53e2z 207 1 ( ( -LRB- cord-299949-kmn53e2z 207 2 Lane Lane NNP cord-299949-kmn53e2z 207 3 et et NNP cord-299949-kmn53e2z 207 4 al al NNP cord-299949-kmn53e2z 207 5 . . NNP cord-299949-kmn53e2z 207 6 , , , cord-299949-kmn53e2z 207 7 1998 1998 CD cord-299949-kmn53e2z 207 8 ) ) -RRB- cord-299949-kmn53e2z 207 9 . . . cord-299949-kmn53e2z 208 1 CXCL10 cxcl10 CD cord-299949-kmn53e2z 208 2 expression expression NN cord-299949-kmn53e2z 208 3 is be VBZ cord-299949-kmn53e2z 208 4 important important JJ cord-299949-kmn53e2z 208 5 for for IN cord-299949-kmn53e2z 208 6 recruitment recruitment NN cord-299949-kmn53e2z 208 7 of of IN cord-299949-kmn53e2z 208 8 T T NNP cord-299949-kmn53e2z 208 9 cells cell NNS cord-299949-kmn53e2z 208 10 ( ( -LRB- cord-299949-kmn53e2z 208 11 Phares Phares NNP cord-299949-kmn53e2z 208 12 et et NNP cord-299949-kmn53e2z 208 13 al al NNP cord-299949-kmn53e2z 208 14 . . NNP cord-299949-kmn53e2z 208 15 , , , cord-299949-kmn53e2z 208 16 2013 2013 CD cord-299949-kmn53e2z 208 17 ) ) -RRB- cord-299949-kmn53e2z 208 18 . . . cord-299949-kmn53e2z 209 1 Proinflammatory proinflammatory JJ cord-299949-kmn53e2z 209 2 cytokine cytokine NN cord-299949-kmn53e2z 209 3 expression expression NN cord-299949-kmn53e2z 209 4 ( ( -LRB- cord-299949-kmn53e2z 209 5 i.e. i.e. FW cord-299949-kmn53e2z 209 6 , , , cord-299949-kmn53e2z 209 7 decreases decrease VBZ cord-299949-kmn53e2z 209 8 as as IN cord-299949-kmn53e2z 209 9 the the DT cord-299949-kmn53e2z 209 10 percentage percentage NN cord-299949-kmn53e2z 209 11 of of IN cord-299949-kmn53e2z 209 12 virus virus NN cord-299949-kmn53e2z 209 13 - - HYPH cord-299949-kmn53e2z 209 14 specific specific JJ cord-299949-kmn53e2z 209 15 CD8 CD8 NNP cord-299949-kmn53e2z 209 16 þ þ NNP cord-299949-kmn53e2z 209 17 T T NNP cord-299949-kmn53e2z 209 18 cells cell NNS cord-299949-kmn53e2z 209 19 and and CC cord-299949-kmn53e2z 209 20 expression expression NN cord-299949-kmn53e2z 209 21 of of IN cord-299949-kmn53e2z 209 22 T T NNP cord-299949-kmn53e2z 209 23 cell cell NN cord-299949-kmn53e2z 209 24 support support NN cord-299949-kmn53e2z 209 25 molecules molecule NNS cord-299949-kmn53e2z 209 26 ( ( -LRB- cord-299949-kmn53e2z 209 27 i.e. i.e. FW cord-299949-kmn53e2z 209 28 , , , cord-299949-kmn53e2z 209 29 CXCL10 CXCL10 NNP cord-299949-kmn53e2z 209 30 , , , cord-299949-kmn53e2z 209 31 CCL5 CCL5 NNP cord-299949-kmn53e2z 209 32 , , , cord-299949-kmn53e2z 209 33 and and CC cord-299949-kmn53e2z 209 34 IFN IFN NNP cord-299949-kmn53e2z 209 35 - - HYPH cord-299949-kmn53e2z 209 36 g g NNP cord-299949-kmn53e2z 209 37 ) ) -RRB- cord-299949-kmn53e2z 209 38 increases increase NNS cord-299949-kmn53e2z 209 39 ( ( -LRB- cord-299949-kmn53e2z 210 1 Lane Lane NNP cord-299949-kmn53e2z 210 2 et et NNP cord-299949-kmn53e2z 210 3 al al NNP cord-299949-kmn53e2z 210 4 . . NNP cord-299949-kmn53e2z 210 5 , , , cord-299949-kmn53e2z 210 6 1998 1998 CD cord-299949-kmn53e2z 210 7 ; ; : cord-299949-kmn53e2z 210 8 Parra Parra NNP cord-299949-kmn53e2z 210 9 et et NNP cord-299949-kmn53e2z 210 10 al al NNP cord-299949-kmn53e2z 210 11 . . NNP cord-299949-kmn53e2z 210 12 , , , cord-299949-kmn53e2z 210 13 1997 1997 CD cord-299949-kmn53e2z 210 14 ) ) -RRB- cord-299949-kmn53e2z 210 15 . . . cord-299949-kmn53e2z 211 1 IFN IFN NNP cord-299949-kmn53e2z 211 2 - - HYPH cord-299949-kmn53e2z 211 3 g g NNP cord-299949-kmn53e2z 211 4 plays play VBZ cord-299949-kmn53e2z 211 5 a a DT cord-299949-kmn53e2z 211 6 key key JJ cord-299949-kmn53e2z 211 7 role role NN cord-299949-kmn53e2z 211 8 in in IN cord-299949-kmn53e2z 211 9 dampening dampen VBG cord-299949-kmn53e2z 211 10 MHV MHV NNP cord-299949-kmn53e2z 211 11 replication replication NN cord-299949-kmn53e2z 211 12 and and CC cord-299949-kmn53e2z 211 13 orchestrating orchestrate VBG cord-299949-kmn53e2z 211 14 T t NN cord-299949-kmn53e2z 211 15 cell cell NN cord-299949-kmn53e2z 211 16 infiltration infiltration NN cord-299949-kmn53e2z 211 17 , , , cord-299949-kmn53e2z 211 18 along along IN cord-299949-kmn53e2z 211 19 with with IN cord-299949-kmn53e2z 211 20 maximal maximal JJ cord-299949-kmn53e2z 211 21 expression expression NN cord-299949-kmn53e2z 211 22 of of IN cord-299949-kmn53e2z 211 23 MHC MHC NNP cord-299949-kmn53e2z 211 24 molecules molecule NNS cord-299949-kmn53e2z 211 25 on on IN cord-299949-kmn53e2z 211 26 microglia microglia NNS cord-299949-kmn53e2z 211 27 and and CC cord-299949-kmn53e2z 211 28 macrophages macrophage NNS cord-299949-kmn53e2z 211 29 ( ( -LRB- cord-299949-kmn53e2z 211 30 Whitman Whitman NNP cord-299949-kmn53e2z 211 31 et et NNP cord-299949-kmn53e2z 211 32 al al NNP cord-299949-kmn53e2z 211 33 . . . cord-299949-kmn53e2z 212 1 , , , cord-299949-kmn53e2z 212 2 2009 2009 CD cord-299949-kmn53e2z 212 3 ; ; : cord-299949-kmn53e2z 212 4 Bergmann Bergmann NNP cord-299949-kmn53e2z 212 5 et et NNP cord-299949-kmn53e2z 212 6 al al NNP cord-299949-kmn53e2z 212 7 . . NNP cord-299949-kmn53e2z 212 8 , , , cord-299949-kmn53e2z 212 9 2004 2004 CD cord-299949-kmn53e2z 213 1 Bergmann Bergmann NNP cord-299949-kmn53e2z 213 2 et et NNP cord-299949-kmn53e2z 213 3 al al NNP cord-299949-kmn53e2z 213 4 . . . cord-299949-kmn53e2z 214 1 , , , cord-299949-kmn53e2z 214 2 , , , cord-299949-kmn53e2z 214 3 2003 2003 CD cord-299949-kmn53e2z 214 4 Parra Parra NNP cord-299949-kmn53e2z 214 5 et et NNP cord-299949-kmn53e2z 214 6 al al NNP cord-299949-kmn53e2z 214 7 . . NNP cord-299949-kmn53e2z 214 8 , , , cord-299949-kmn53e2z 214 9 1997 1997 CD cord-299949-kmn53e2z 214 10 ) ) -RRB- cord-299949-kmn53e2z 214 11 . . . cord-299949-kmn53e2z 215 1 Infiltrating infiltrate VBG cord-299949-kmn53e2z 215 2 CD4 CD4 NNP cord-299949-kmn53e2z 215 3 þ þ NNP cord-299949-kmn53e2z 215 4 T t NN cord-299949-kmn53e2z 215 5 cells cell NNS cord-299949-kmn53e2z 215 6 accumulate accumulate VBP cord-299949-kmn53e2z 215 7 around around IN cord-299949-kmn53e2z 215 8 blood blood NN cord-299949-kmn53e2z 215 9 vessels vessel NNS cord-299949-kmn53e2z 215 10 and and CC cord-299949-kmn53e2z 215 11 provide provide VB cord-299949-kmn53e2z 215 12 supporting support VBG cord-299949-kmn53e2z 215 13 factors factor NNS cord-299949-kmn53e2z 215 14 for for IN cord-299949-kmn53e2z 215 15 infiltrating infiltrate VBG cord-299949-kmn53e2z 215 16 CD8 CD8 NNP cord-299949-kmn53e2z 215 17 þ þ NNP cord-299949-kmn53e2z 215 18 T T NNP cord-299949-kmn53e2z 215 19 cells cell NNS cord-299949-kmn53e2z 215 20 that that WDT cord-299949-kmn53e2z 215 21 invade invade VBP cord-299949-kmn53e2z 215 22 the the DT cord-299949-kmn53e2z 215 23 parenchyma parenchyma NN cord-299949-kmn53e2z 215 24 at at IN cord-299949-kmn53e2z 215 25 the the DT cord-299949-kmn53e2z 215 26 site site NN cord-299949-kmn53e2z 215 27 of of IN cord-299949-kmn53e2z 215 28 infection infection NN cord-299949-kmn53e2z 216 1 ( ( -LRB- cord-299949-kmn53e2z 216 2 Phares Phares NNP cord-299949-kmn53e2z 216 3 et et NNP cord-299949-kmn53e2z 216 4 al al NNP cord-299949-kmn53e2z 216 5 . . NNP cord-299949-kmn53e2z 216 6 , , , cord-299949-kmn53e2z 216 7 2011 2011 CD cord-299949-kmn53e2z 217 1 ; ; : cord-299949-kmn53e2z 217 2 Stohlman Stohlman NNP cord-299949-kmn53e2z 217 3 et et NNP cord-299949-kmn53e2z 217 4 al al NNP cord-299949-kmn53e2z 217 5 . . NNP cord-299949-kmn53e2z 217 6 , , , cord-299949-kmn53e2z 217 7 1998 1998 CD cord-299949-kmn53e2z 217 8 ) ) -RRB- cord-299949-kmn53e2z 217 9 . . . cord-299949-kmn53e2z 218 1 Granzyme Granzyme NNP cord-299949-kmn53e2z 218 2 B b NN cord-299949-kmn53e2z 218 3 - - HYPH cord-299949-kmn53e2z 218 4 positive positive JJ cord-299949-kmn53e2z 218 5 CD8 CD8 NNP cord-299949-kmn53e2z 218 6 þ þ NNP cord-299949-kmn53e2z 218 7 T T NNP cord-299949-kmn53e2z 218 8 cells cell NNS cord-299949-kmn53e2z 218 9 target target VBP cord-299949-kmn53e2z 218 10 MHC MHC NNP cord-299949-kmn53e2z 218 11 class class NN cord-299949-kmn53e2z 218 12 I i NN cord-299949-kmn53e2z 218 13 - - HYPH cord-299949-kmn53e2z 218 14 positive positive JJ cord-299949-kmn53e2z 218 15 , , , cord-299949-kmn53e2z 218 16 infected infected JJ cord-299949-kmn53e2z 218 17 cells cell NNS cord-299949-kmn53e2z 218 18 for for IN cord-299949-kmn53e2z 218 19 cytolysis cytolysis NN cord-299949-kmn53e2z 218 20 , , , cord-299949-kmn53e2z 218 21 but but CC cord-299949-kmn53e2z 218 22 effector effector JJ cord-299949-kmn53e2z 218 23 function function NN cord-299949-kmn53e2z 218 24 may may MD cord-299949-kmn53e2z 218 25 be be VB cord-299949-kmn53e2z 218 26 specific specific JJ cord-299949-kmn53e2z 218 27 for for IN cord-299949-kmn53e2z 218 28 the the DT cord-299949-kmn53e2z 218 29 targeted target VBN cord-299949-kmn53e2z 218 30 cell cell NN cord-299949-kmn53e2z 218 31 type type NN cord-299949-kmn53e2z 218 32 Lin Lin NNP cord-299949-kmn53e2z 218 33 et et NNP cord-299949-kmn53e2z 218 34 al al NNP cord-299949-kmn53e2z 218 35 . . NNP cord-299949-kmn53e2z 218 36 , , , cord-299949-kmn53e2z 218 37 1997 1997 CD cord-299949-kmn53e2z 218 38 ) ) -RRB- cord-299949-kmn53e2z 218 39 . . . cord-299949-kmn53e2z 219 1 IFN IFN NNP cord-299949-kmn53e2z 219 2 - - HYPH cord-299949-kmn53e2z 219 3 g g NNP cord-299949-kmn53e2z 219 4 is be VBZ cord-299949-kmn53e2z 219 5 particularly particularly RB cord-299949-kmn53e2z 219 6 important important JJ cord-299949-kmn53e2z 219 7 for for IN cord-299949-kmn53e2z 219 8 clearance clearance NN cord-299949-kmn53e2z 219 9 from from IN cord-299949-kmn53e2z 219 10 oligodendrocytes oligodendrocyte NNS cord-299949-kmn53e2z 219 11 , , , cord-299949-kmn53e2z 219 12 whereas whereas IN cord-299949-kmn53e2z 219 13 perforin perforin NNP cord-299949-kmn53e2z 219 14 and and CC cord-299949-kmn53e2z 219 15 CD8 CD8 NNP cord-299949-kmn53e2z 219 16 þ þ NNP cord-299949-kmn53e2z 219 17 T T NNP cord-299949-kmn53e2z 219 18 cell cell NN cord-299949-kmn53e2z 219 19 - - HYPH cord-299949-kmn53e2z 219 20 mediated mediate VBN cord-299949-kmn53e2z 219 21 cytolysis cytolysis NN cord-299949-kmn53e2z 219 22 is be VBZ cord-299949-kmn53e2z 219 23 important important JJ cord-299949-kmn53e2z 219 24 for for IN cord-299949-kmn53e2z 219 25 the the DT cord-299949-kmn53e2z 219 26 clearance clearance NN cord-299949-kmn53e2z 219 27 of of IN cord-299949-kmn53e2z 219 28 virus virus NN cord-299949-kmn53e2z 219 29 from from IN cord-299949-kmn53e2z 219 30 astrocytes astrocyte NNS cord-299949-kmn53e2z 219 31 and and CC cord-299949-kmn53e2z 219 32 microglia microglia NNS cord-299949-kmn53e2z 219 33 ( ( -LRB- cord-299949-kmn53e2z 219 34 González González NNP cord-299949-kmn53e2z 219 35 et et NNP cord-299949-kmn53e2z 219 36 al al NNP cord-299949-kmn53e2z 219 37 . . . cord-299949-kmn53e2z 220 1 , , , cord-299949-kmn53e2z 220 2 2005 2005 CD cord-299949-kmn53e2z 220 3 ; ; : cord-299949-kmn53e2z 220 4 Bergmann Bergmann NNP cord-299949-kmn53e2z 220 5 et et NNP cord-299949-kmn53e2z 220 6 al al NNP cord-299949-kmn53e2z 220 7 . . NNP cord-299949-kmn53e2z 220 8 , , , cord-299949-kmn53e2z 220 9 2003 2003 CD cord-299949-kmn53e2z 220 10 ; ; : cord-299949-kmn53e2z 220 11 Parra Parra NNP cord-299949-kmn53e2z 220 12 et et NNP cord-299949-kmn53e2z 220 13 al al NNP cord-299949-kmn53e2z 220 14 . . NNP cord-299949-kmn53e2z 220 15 , , , cord-299949-kmn53e2z 220 16 1999 1999 CD cord-299949-kmn53e2z 220 17 ; ; : cord-299949-kmn53e2z 220 18 Lin Lin NNP cord-299949-kmn53e2z 220 19 et et NNP cord-299949-kmn53e2z 220 20 al al NNP cord-299949-kmn53e2z 220 21 . . NNP cord-299949-kmn53e2z 220 22 , , , cord-299949-kmn53e2z 220 23 1997 1997 CD cord-299949-kmn53e2z 220 24 ; ; : cord-299949-kmn53e2z 220 25 Stohlman Stohlman NNP cord-299949-kmn53e2z 220 26 et et NNP cord-299949-kmn53e2z 220 27 al al NNP cord-299949-kmn53e2z 220 28 . . NNP cord-299949-kmn53e2z 220 29 , , , cord-299949-kmn53e2z 220 30 1995 1995 CD cord-299949-kmn53e2z 220 31 ) ) -RRB- cord-299949-kmn53e2z 220 32 . . . cord-299949-kmn53e2z 221 1 Oligodendrocyte Oligodendrocyte NNP cord-299949-kmn53e2z 221 2 killing kill VBG cord-299949-kmn53e2z 221 3 by by IN cord-299949-kmn53e2z 221 4 CD8 CD8 NNP cord-299949-kmn53e2z 221 5 þ þ NNP cord-299949-kmn53e2z 221 6 T T NNP cord-299949-kmn53e2z 221 7 cells cell NNS cord-299949-kmn53e2z 221 8 results result NNS cord-299949-kmn53e2z 221 9 in in IN cord-299949-kmn53e2z 221 10 demyelination demyelination NN cord-299949-kmn53e2z 221 11 during during IN cord-299949-kmn53e2z 221 12 the the DT cord-299949-kmn53e2z 221 13 acute acute JJ cord-299949-kmn53e2z 221 14 phase phase NN cord-299949-kmn53e2z 221 15 of of IN cord-299949-kmn53e2z 221 16 infection infection NN cord-299949-kmn53e2z 221 17 ( ( -LRB- cord-299949-kmn53e2z 221 18 Templeton Templeton NNP cord-299949-kmn53e2z 221 19 and and CC cord-299949-kmn53e2z 221 20 Perlman Perlman NNP cord-299949-kmn53e2z 221 21 , , , cord-299949-kmn53e2z 221 22 2008 2008 CD cord-299949-kmn53e2z 221 23 ) ) -RRB- cord-299949-kmn53e2z 221 24 . . . cord-299949-kmn53e2z 222 1 Cytolytic cytolytic JJ cord-299949-kmn53e2z 222 2 function function NN cord-299949-kmn53e2z 222 3 declines decline VBZ cord-299949-kmn53e2z 222 4 concomitant concomitant JJ cord-299949-kmn53e2z 222 5 with with IN cord-299949-kmn53e2z 222 6 loss loss NN cord-299949-kmn53e2z 222 7 of of IN cord-299949-kmn53e2z 222 8 viral viral JJ cord-299949-kmn53e2z 222 9 antigen antigen NN cord-299949-kmn53e2z 222 10 Lin Lin NNP cord-299949-kmn53e2z 222 11 et et FW cord-299949-kmn53e2z 222 12 al al NNP cord-299949-kmn53e2z 222 13 . . NNP cord-299949-kmn53e2z 222 14 , , , cord-299949-kmn53e2z 222 15 1999 1999 CD cord-299949-kmn53e2z 222 16 ) ) -RRB- cord-299949-kmn53e2z 222 17 . . . cord-299949-kmn53e2z 223 1 Viral Viral NNP cord-299949-kmn53e2z 223 2 RNA RNA NNP cord-299949-kmn53e2z 223 3 persists persist VBZ cord-299949-kmn53e2z 223 4 within within IN cord-299949-kmn53e2z 223 5 the the DT cord-299949-kmn53e2z 223 6 CNS CNS NNP cord-299949-kmn53e2z 223 7 for for IN cord-299949-kmn53e2z 223 8 over over IN cord-299949-kmn53e2z 223 9 12 12 CD cord-299949-kmn53e2z 223 10 months month NNS cord-299949-kmn53e2z 223 11 , , , cord-299949-kmn53e2z 223 12 regardless regardless RB cord-299949-kmn53e2z 223 13 of of IN cord-299949-kmn53e2z 223 14 the the DT cord-299949-kmn53e2z 223 15 presence presence NN cord-299949-kmn53e2z 223 16 of of IN cord-299949-kmn53e2z 223 17 nonanergic nonanergic NNP cord-299949-kmn53e2z 223 18 , , , cord-299949-kmn53e2z 223 19 virus virus NN cord-299949-kmn53e2z 223 20 - - HYPH cord-299949-kmn53e2z 223 21 specific specific JJ cord-299949-kmn53e2z 223 22 CD4 CD4 NNP cord-299949-kmn53e2z 223 23 þ þ NNP cord-299949-kmn53e2z 223 24 and and CC cord-299949-kmn53e2z 223 25 CD8 CD8 NNP cord-299949-kmn53e2z 223 26 þ þ NNP cord-299949-kmn53e2z 223 27 T T NNP cord-299949-kmn53e2z 223 28 cells cell NNS cord-299949-kmn53e2z 223 29 retained retain VBN cord-299949-kmn53e2z 223 30 in in IN cord-299949-kmn53e2z 223 31 the the DT cord-299949-kmn53e2z 223 32 CNS CNS NNP cord-299949-kmn53e2z 223 33 ( ( -LRB- cord-299949-kmn53e2z 223 34 Phares Phares NNP cord-299949-kmn53e2z 223 35 et et NNP cord-299949-kmn53e2z 223 36 al al NNP cord-299949-kmn53e2z 223 37 . . NNP cord-299949-kmn53e2z 223 38 , , , cord-299949-kmn53e2z 223 39 2011 2011 CD cord-299949-kmn53e2z 224 1 ( ( -LRB- cord-299949-kmn53e2z 224 2 Phares Phares NNP cord-299949-kmn53e2z 224 3 et et NNP cord-299949-kmn53e2z 224 4 al al NNP cord-299949-kmn53e2z 224 5 . . . cord-299949-kmn53e2z 225 1 , , , cord-299949-kmn53e2z 225 2 , , , cord-299949-kmn53e2z 225 3 2010 2010 CD cord-299949-kmn53e2z 225 4 Ramakrishna Ramakrishna NNP cord-299949-kmn53e2z 225 5 et et NNP cord-299949-kmn53e2z 225 6 al al NNP cord-299949-kmn53e2z 225 7 . . NNP cord-299949-kmn53e2z 225 8 , , , cord-299949-kmn53e2z 225 9 2004 2004 CD cord-299949-kmn53e2z 225 10 ; ; : cord-299949-kmn53e2z 226 1 Bergmann Bergmann NNP cord-299949-kmn53e2z 226 2 et et NNP cord-299949-kmn53e2z 226 3 al al NNP cord-299949-kmn53e2z 226 4 . . NNP cord-299949-kmn53e2z 226 5 , , , cord-299949-kmn53e2z 226 6 1999 1999 CD cord-299949-kmn53e2z 226 7 ) ) -RRB- cord-299949-kmn53e2z 226 8 . . . cord-299949-kmn53e2z 227 1 Additionally additionally RB cord-299949-kmn53e2z 227 2 , , , cord-299949-kmn53e2z 227 3 persistent persistent JJ cord-299949-kmn53e2z 227 4 oligodendrocyte oligodendrocyte NNP cord-299949-kmn53e2z 227 5 infection infection NN cord-299949-kmn53e2z 227 6 and and CC cord-299949-kmn53e2z 227 7 the the DT cord-299949-kmn53e2z 227 8 consequent consequent JJ cord-299949-kmn53e2z 227 9 immune immune JJ cord-299949-kmn53e2z 227 10 response response NN cord-299949-kmn53e2z 227 11 are be VBP cord-299949-kmn53e2z 227 12 associated associate VBN cord-299949-kmn53e2z 227 13 with with IN cord-299949-kmn53e2z 227 14 chronic chronic JJ cord-299949-kmn53e2z 227 15 demyelination demyelination NN cord-299949-kmn53e2z 227 16 . . . cord-299949-kmn53e2z 228 1 Long long JJ cord-299949-kmn53e2z 228 2 - - HYPH cord-299949-kmn53e2z 228 3 term term NN cord-299949-kmn53e2z 228 4 control control NN cord-299949-kmn53e2z 228 5 of of IN cord-299949-kmn53e2z 228 6 virus virus NN cord-299949-kmn53e2z 228 7 infection infection NN cord-299949-kmn53e2z 228 8 ( ( -LRB- cord-299949-kmn53e2z 228 9 Figure figure NN cord-299949-kmn53e2z 228 10 2(c 2(c CD cord-299949-kmn53e2z 228 11 ) ) -RRB- cord-299949-kmn53e2z 228 12 ) ) -RRB- cord-299949-kmn53e2z 228 13 , , , cord-299949-kmn53e2z 228 14 regardless regardless RB cord-299949-kmn53e2z 228 15 of of IN cord-299949-kmn53e2z 228 16 infected infected JJ cord-299949-kmn53e2z 228 17 cell cell NN cord-299949-kmn53e2z 228 18 type type NN cord-299949-kmn53e2z 228 19 , , , cord-299949-kmn53e2z 228 20 is be VBZ cord-299949-kmn53e2z 228 21 characterized characterize VBN cord-299949-kmn53e2z 228 22 by by IN cord-299949-kmn53e2z 228 23 virus virus NN cord-299949-kmn53e2z 228 24 - - HYPH cord-299949-kmn53e2z 228 25 specific specific JJ cord-299949-kmn53e2z 228 26 antibody antibody NN cord-299949-kmn53e2z 228 27 , , , cord-299949-kmn53e2z 228 28 a a DT cord-299949-kmn53e2z 228 29 lack lack NN cord-299949-kmn53e2z 228 30 of of IN cord-299949-kmn53e2z 228 31 infectious infectious JJ cord-299949-kmn53e2z 228 32 virus virus NN cord-299949-kmn53e2z 228 33 , , , cord-299949-kmn53e2z 228 34 and and CC cord-299949-kmn53e2z 228 35 low low JJ cord-299949-kmn53e2z 228 36 levels level NNS cord-299949-kmn53e2z 228 37 of of IN cord-299949-kmn53e2z 228 38 viral viral JJ cord-299949-kmn53e2z 228 39 RNA RNA NNP cord-299949-kmn53e2z 228 40 that that WDT cord-299949-kmn53e2z 228 41 are be VBP cord-299949-kmn53e2z 228 42 detected detect VBN cord-299949-kmn53e2z 228 43 by by IN cord-299949-kmn53e2z 228 44 sensitive sensitive JJ cord-299949-kmn53e2z 228 45 methods method NNS cord-299949-kmn53e2z 228 46 such such JJ cord-299949-kmn53e2z 228 47 as as IN cord-299949-kmn53e2z 228 48 qPCR qPCR NNP cord-299949-kmn53e2z 228 49 ( ( -LRB- cord-299949-kmn53e2z 228 50 Metcalf Metcalf NNP cord-299949-kmn53e2z 228 51 and and CC cord-299949-kmn53e2z 228 52 Griffin Griffin NNP cord-299949-kmn53e2z 228 53 , , , cord-299949-kmn53e2z 228 54 2011 2011 CD cord-299949-kmn53e2z 228 55 ; ; : cord-299949-kmn53e2z 228 56 Stewart Stewart NNP cord-299949-kmn53e2z 228 57 et et NNP cord-299949-kmn53e2z 228 58 al al NNP cord-299949-kmn53e2z 228 59 . . NNP cord-299949-kmn53e2z 228 60 , , , cord-299949-kmn53e2z 228 61 2011 2011 CD cord-299949-kmn53e2z 228 62 ; ; : cord-299949-kmn53e2z 228 63 Appler Appler NNP cord-299949-kmn53e2z 228 64 et et NNP cord-299949-kmn53e2z 228 65 al al NNP cord-299949-kmn53e2z 228 66 . . NNP cord-299949-kmn53e2z 228 67 , , , cord-299949-kmn53e2z 228 68 2010 2010 CD cord-299949-kmn53e2z 228 69 ; ; : cord-299949-kmn53e2z 228 70 Fragkoudis Fragkoudis NNP cord-299949-kmn53e2z 228 71 et et NNP cord-299949-kmn53e2z 228 72 al al NNP cord-299949-kmn53e2z 228 73 . . NNP cord-299949-kmn53e2z 228 74 , , , cord-299949-kmn53e2z 228 75 2008 2008 CD cord-299949-kmn53e2z 228 76 ; ; . cord-299949-kmn53e2z 229 1 Tschen Tschen NNP cord-299949-kmn53e2z 229 2 et et NNP cord-299949-kmn53e2z 229 3 al al NNP cord-299949-kmn53e2z 229 4 . . . cord-299949-kmn53e2z 230 1 , , , cord-299949-kmn53e2z 230 2 2002 2002 CD cord-299949-kmn53e2z 230 3 ; ; : cord-299949-kmn53e2z 230 4 Tyor Tyor NNP cord-299949-kmn53e2z 230 5 et et NNP cord-299949-kmn53e2z 230 6 al al NNP cord-299949-kmn53e2z 230 7 . . NNP cord-299949-kmn53e2z 230 8 , , , cord-299949-kmn53e2z 230 9 1992 1992 CD cord-299949-kmn53e2z 230 10 ) ) -RRB- cord-299949-kmn53e2z 230 11 . . . cord-299949-kmn53e2z 231 1 Although although IN cord-299949-kmn53e2z 231 2 control control NN cord-299949-kmn53e2z 231 3 of of IN cord-299949-kmn53e2z 231 4 the the DT cord-299949-kmn53e2z 231 5 acute acute JJ cord-299949-kmn53e2z 231 6 phase phase NN cord-299949-kmn53e2z 231 7 of of IN cord-299949-kmn53e2z 231 8 MHV MHV NNP cord-299949-kmn53e2z 231 9 infection infection NN cord-299949-kmn53e2z 231 10 by by IN cord-299949-kmn53e2z 231 11 the the DT cord-299949-kmn53e2z 231 12 adaptive adaptive JJ cord-299949-kmn53e2z 231 13 response response NN cord-299949-kmn53e2z 231 14 is be VBZ cord-299949-kmn53e2z 231 15 independent independent JJ cord-299949-kmn53e2z 231 16 of of IN cord-299949-kmn53e2z 231 17 antibody antibody NN cord-299949-kmn53e2z 231 18 , , , cord-299949-kmn53e2z 231 19 long long JJ cord-299949-kmn53e2z 231 20 - - HYPH cord-299949-kmn53e2z 231 21 term term NN cord-299949-kmn53e2z 231 22 production production NN cord-299949-kmn53e2z 231 23 of of IN cord-299949-kmn53e2z 231 24 antibody antibody NN cord-299949-kmn53e2z 231 25 is be VBZ cord-299949-kmn53e2z 231 26 necessary necessary JJ cord-299949-kmn53e2z 231 27 to to TO cord-299949-kmn53e2z 231 28 prevent prevent VB cord-299949-kmn53e2z 231 29 reactivation reactivation NN cord-299949-kmn53e2z 231 30 of of IN cord-299949-kmn53e2z 231 31 infection infection NN cord-299949-kmn53e2z 231 32 Lin Lin NNP cord-299949-kmn53e2z 231 33 et et NNP cord-299949-kmn53e2z 231 34 al al NNP cord-299949-kmn53e2z 231 35 . . NNP cord-299949-kmn53e2z 231 36 , , , cord-299949-kmn53e2z 231 37 1999 1999 CD cord-299949-kmn53e2z 231 38 ) ) -RRB- cord-299949-kmn53e2z 231 39 . . . cord-299949-kmn53e2z 232 1 As as IN cord-299949-kmn53e2z 232 2 the the DT cord-299949-kmn53e2z 232 3 BBB BBB NNP cord-299949-kmn53e2z 232 4 does do VBZ cord-299949-kmn53e2z 232 5 not not RB cord-299949-kmn53e2z 232 6 allow allow VB cord-299949-kmn53e2z 232 7 antibody antibody NN cord-299949-kmn53e2z 232 8 to to TO cord-299949-kmn53e2z 232 9 efficiently efficiently RB cord-299949-kmn53e2z 232 10 enter enter VB cord-299949-kmn53e2z 232 11 the the DT cord-299949-kmn53e2z 232 12 CNS CNS NNP cord-299949-kmn53e2z 232 13 from from IN cord-299949-kmn53e2z 232 14 the the DT cord-299949-kmn53e2z 232 15 periphery periphery NN cord-299949-kmn53e2z 232 16 , , , cord-299949-kmn53e2z 232 17 ASCs ASCs NNP cord-299949-kmn53e2z 232 18 must must MD cord-299949-kmn53e2z 232 19 either either CC cord-299949-kmn53e2z 232 20 be be VB cord-299949-kmn53e2z 232 21 continuously continuously RB cord-299949-kmn53e2z 232 22 recruited recruit VBN cord-299949-kmn53e2z 232 23 to to IN cord-299949-kmn53e2z 232 24 the the DT cord-299949-kmn53e2z 232 25 CNS CNS NNP cord-299949-kmn53e2z 232 26 or or CC cord-299949-kmn53e2z 232 27 maintained maintain VBN cord-299949-kmn53e2z 232 28 in in IN cord-299949-kmn53e2z 232 29 the the DT cord-299949-kmn53e2z 232 30 brain brain NN cord-299949-kmn53e2z 232 31 parenchyma parenchyma NN cord-299949-kmn53e2z 232 32 to to TO cord-299949-kmn53e2z 232 33 produce produce VB cord-299949-kmn53e2z 232 34 antibody antibody NN cord-299949-kmn53e2z 232 35 locally locally RB cord-299949-kmn53e2z 233 1 ( ( -LRB- cord-299949-kmn53e2z 233 2 Metcalf Metcalf NNP cord-299949-kmn53e2z 233 3 et et NNP cord-299949-kmn53e2z 233 4 al al NNP cord-299949-kmn53e2z 233 5 . . NNP cord-299949-kmn53e2z 233 6 , , , cord-299949-kmn53e2z 233 7 2013 2013 CD cord-299949-kmn53e2z 233 8 ; ; : cord-299949-kmn53e2z 234 1 Stewart Stewart NNP cord-299949-kmn53e2z 234 2 et et NNP cord-299949-kmn53e2z 234 3 al al NNP cord-299949-kmn53e2z 234 4 . . NNP cord-299949-kmn53e2z 234 5 , , , cord-299949-kmn53e2z 234 6 2011 2011 CD cord-299949-kmn53e2z 234 7 ; ; : cord-299949-kmn53e2z 235 1 Hooper Hooper NNP cord-299949-kmn53e2z 235 2 et et NNP cord-299949-kmn53e2z 235 3 al al NNP cord-299949-kmn53e2z 235 4 . . NNP cord-299949-kmn53e2z 235 5 , , , cord-299949-kmn53e2z 235 6 2009 2009 CD cord-299949-kmn53e2z 235 7 ; ; : cord-299949-kmn53e2z 235 8 Diamond Diamond NNP cord-299949-kmn53e2z 235 9 , , , cord-299949-kmn53e2z 235 10 2003 2003 CD cord-299949-kmn53e2z 235 11 ; ; : cord-299949-kmn53e2z 235 12 Diamond Diamond NNP cord-299949-kmn53e2z 235 13 et et NNP cord-299949-kmn53e2z 235 14 al al NNP cord-299949-kmn53e2z 235 15 . . NNP cord-299949-kmn53e2z 235 16 , , , cord-299949-kmn53e2z 235 17 2003 2003 CD cord-299949-kmn53e2z 235 18 ; ; : cord-299949-kmn53e2z 235 19 Ramakrishna Ramakrishna NNP cord-299949-kmn53e2z 235 20 et et NNP cord-299949-kmn53e2z 235 21 al al NNP cord-299949-kmn53e2z 235 22 . . NNP cord-299949-kmn53e2z 235 23 , , , cord-299949-kmn53e2z 235 24 2002 2002 CD cord-299949-kmn53e2z 235 25 ; ; : cord-299949-kmn53e2z 236 1 Tyor Tyor NNP cord-299949-kmn53e2z 236 2 et et NNP cord-299949-kmn53e2z 236 3 al al NNP cord-299949-kmn53e2z 236 4 . . NNP cord-299949-kmn53e2z 236 5 , , , cord-299949-kmn53e2z 236 6 1992 1992 CD cord-299949-kmn53e2z 236 7 ; ; : cord-299949-kmn53e2z 236 8 Levine Levine NNP cord-299949-kmn53e2z 236 9 and and CC cord-299949-kmn53e2z 236 10 Griffin Griffin NNP cord-299949-kmn53e2z 236 11 , , , cord-299949-kmn53e2z 236 12 1992 1992 CD cord-299949-kmn53e2z 236 13 ; ; : cord-299949-kmn53e2z 236 14 Parsons Parsons NNP cord-299949-kmn53e2z 236 15 , , , cord-299949-kmn53e2z 236 16 1989 1989 CD cord-299949-kmn53e2z 236 17 ) ) -RRB- cord-299949-kmn53e2z 236 18 . . . cord-299949-kmn53e2z 237 1 Antibody antibody NN cord-299949-kmn53e2z 237 2 controls control VBZ cord-299949-kmn53e2z 237 3 persistent persistent JJ cord-299949-kmn53e2z 237 4 infection infection NN cord-299949-kmn53e2z 237 5 in in IN cord-299949-kmn53e2z 237 6 the the DT cord-299949-kmn53e2z 237 7 CNS CNS NNP cord-299949-kmn53e2z 237 8 through through IN cord-299949-kmn53e2z 237 9 a a DT cord-299949-kmn53e2z 237 10 multifaceted multifaceted JJ cord-299949-kmn53e2z 237 11 defense defense NN cord-299949-kmn53e2z 237 12 strategy strategy NN cord-299949-kmn53e2z 237 13 that that WDT cord-299949-kmn53e2z 237 14 preserves preserve VBZ cord-299949-kmn53e2z 237 15 neuronal neuronal JJ cord-299949-kmn53e2z 237 16 function function NN cord-299949-kmn53e2z 237 17 following follow VBG cord-299949-kmn53e2z 237 18 infection infection NN cord-299949-kmn53e2z 237 19 . . . cord-299949-kmn53e2z 238 1 The the DT cord-299949-kmn53e2z 238 2 need need NN cord-299949-kmn53e2z 238 3 for for IN cord-299949-kmn53e2z 238 4 continued continued JJ cord-299949-kmn53e2z 238 5 antibody antibody NN cord-299949-kmn53e2z 238 6 production production NN cord-299949-kmn53e2z 238 7 in in IN cord-299949-kmn53e2z 238 8 the the DT cord-299949-kmn53e2z 238 9 CNS CNS NNP cord-299949-kmn53e2z 238 10 is be VBZ cord-299949-kmn53e2z 238 11 highlighted highlight VBN cord-299949-kmn53e2z 238 12 in in IN cord-299949-kmn53e2z 238 13 studies study NNS cord-299949-kmn53e2z 238 14 where where WRB cord-299949-kmn53e2z 238 15 passive passive JJ cord-299949-kmn53e2z 238 16 transfer transfer NN cord-299949-kmn53e2z 238 17 of of IN cord-299949-kmn53e2z 238 18 antibody antibody NN cord-299949-kmn53e2z 238 19 blocked block VBD cord-299949-kmn53e2z 238 20 recrudescence recrudescence NN cord-299949-kmn53e2z 238 21 only only RB cord-299949-kmn53e2z 238 22 during during IN cord-299949-kmn53e2z 238 23 the the DT cord-299949-kmn53e2z 238 24 time time NN cord-299949-kmn53e2z 238 25 of of IN cord-299949-kmn53e2z 238 26 treatment treatment NN cord-299949-kmn53e2z 238 27 Levine Levine NNP cord-299949-kmn53e2z 238 28 and and CC cord-299949-kmn53e2z 238 29 Griffin Griffin NNP cord-299949-kmn53e2z 238 30 , , , cord-299949-kmn53e2z 238 31 1992 1992 CD cord-299949-kmn53e2z 238 32 ; ; : cord-299949-kmn53e2z 238 33 Levine Levine NNP cord-299949-kmn53e2z 238 34 et et NNP cord-299949-kmn53e2z 238 35 al al NNP cord-299949-kmn53e2z 238 36 . . NNP cord-299949-kmn53e2z 238 37 , , , cord-299949-kmn53e2z 238 38 1991 1991 CD cord-299949-kmn53e2z 238 39 ) ) -RRB- cord-299949-kmn53e2z 238 40 . . . cord-299949-kmn53e2z 239 1 Molecular molecular JJ cord-299949-kmn53e2z 239 2 cues cue NNS cord-299949-kmn53e2z 239 3 in in IN cord-299949-kmn53e2z 239 4 the the DT cord-299949-kmn53e2z 239 5 brain brain NN cord-299949-kmn53e2z 239 6 microenvironment microenvironment NN cord-299949-kmn53e2z 239 7 orchestrate orchestrate VBP cord-299949-kmn53e2z 239 8 ASC ASC NNP cord-299949-kmn53e2z 239 9 recruitment recruitment NN cord-299949-kmn53e2z 239 10 , , , cord-299949-kmn53e2z 239 11 retention retention NN cord-299949-kmn53e2z 239 12 , , , cord-299949-kmn53e2z 239 13 and and CC cord-299949-kmn53e2z 239 14 maturation maturation NN cord-299949-kmn53e2z 239 15 . . . cord-299949-kmn53e2z 240 1 ASCs asc NNS cord-299949-kmn53e2z 240 2 remain remain VBP cord-299949-kmn53e2z 240 3 in in IN cord-299949-kmn53e2z 240 4 the the DT cord-299949-kmn53e2z 240 5 CNS CNS NNP cord-299949-kmn53e2z 240 6 to to TO cord-299949-kmn53e2z 240 7 block block VB cord-299949-kmn53e2z 240 8 reactivation reactivation NN cord-299949-kmn53e2z 240 9 of of IN cord-299949-kmn53e2z 240 10 virus virus NN cord-299949-kmn53e2z 240 11 replication replication NN cord-299949-kmn53e2z 240 12 . . . cord-299949-kmn53e2z 241 1 The the DT cord-299949-kmn53e2z 241 2 mechanisms mechanism NNS cord-299949-kmn53e2z 241 3 for for IN cord-299949-kmn53e2z 241 4 recruitment recruitment NN cord-299949-kmn53e2z 241 5 and and CC cord-299949-kmn53e2z 241 6 retention retention NN cord-299949-kmn53e2z 241 7 have have VBP cord-299949-kmn53e2z 241 8 been be VBN cord-299949-kmn53e2z 241 9 characterized characterize VBN cord-299949-kmn53e2z 241 10 during during IN cord-299949-kmn53e2z 241 11 MHV MHV NNP cord-299949-kmn53e2z 241 12 and and CC cord-299949-kmn53e2z 241 13 SINV SINV NNP cord-299949-kmn53e2z 241 14 infection infection NN cord-299949-kmn53e2z 241 15 ( ( -LRB- cord-299949-kmn53e2z 241 16 Metcalf Metcalf NNP cord-299949-kmn53e2z 241 17 and and CC cord-299949-kmn53e2z 241 18 Griffin Griffin NNP cord-299949-kmn53e2z 241 19 , , , cord-299949-kmn53e2z 241 20 2011 2011 CD cord-299949-kmn53e2z 241 21 ; ; : cord-299949-kmn53e2z 241 22 Marques Marques NNP cord-299949-kmn53e2z 241 23 et et NNP cord-299949-kmn53e2z 241 24 al al NNP cord-299949-kmn53e2z 241 25 . . . cord-299949-kmn53e2z 242 1 , , , cord-299949-kmn53e2z 242 2 2011 2011 CD cord-299949-kmn53e2z 242 3 ; ; : cord-299949-kmn53e2z 242 4 Lin Lin NNP cord-299949-kmn53e2z 242 5 et et NNP cord-299949-kmn53e2z 242 6 al al NNP cord-299949-kmn53e2z 242 7 . . . cord-299949-kmn53e2z 243 1 , , , cord-299949-kmn53e2z 243 2 1999 1999 CD cord-299949-kmn53e2z 243 3 ; ; : cord-299949-kmn53e2z 243 4 Tyor Tyor NNP cord-299949-kmn53e2z 243 5 and and CC cord-299949-kmn53e2z 243 6 Griffin Griffin NNP cord-299949-kmn53e2z 243 7 , , , cord-299949-kmn53e2z 243 8 1993 1993 CD cord-299949-kmn53e2z 243 9 ) ) -RRB- cord-299949-kmn53e2z 243 10 . . . cord-299949-kmn53e2z 244 1 The the DT cord-299949-kmn53e2z 244 2 chemokine chemokine NN cord-299949-kmn53e2z 244 3 receptor receptor NN cord-299949-kmn53e2z 244 4 CXCR3 cxcr3 NN cord-299949-kmn53e2z 244 5 and and CC cord-299949-kmn53e2z 244 6 its -PRON- PRP$ cord-299949-kmn53e2z 244 7 ligand ligand NN cord-299949-kmn53e2z 245 1 CXCL10 CXCL10 NNP cord-299949-kmn53e2z 245 2 are be VBP cord-299949-kmn53e2z 245 3 critical critical JJ cord-299949-kmn53e2z 245 4 for for IN cord-299949-kmn53e2z 245 5 recruitment recruitment NN cord-299949-kmn53e2z 245 6 of of IN cord-299949-kmn53e2z 245 7 ASCs ASCs NNP cord-299949-kmn53e2z 245 8 to to IN cord-299949-kmn53e2z 245 9 the the DT cord-299949-kmn53e2z 245 10 CNS CNS NNP cord-299949-kmn53e2z 245 11 during during IN cord-299949-kmn53e2z 245 12 MHV MHV NNP cord-299949-kmn53e2z 245 13 infection infection NN cord-299949-kmn53e2z 246 1 ( ( -LRB- cord-299949-kmn53e2z 246 2 Phares Phares NNP cord-299949-kmn53e2z 246 3 et et NNP cord-299949-kmn53e2z 246 4 al al NNP cord-299949-kmn53e2z 246 5 . . NNP cord-299949-kmn53e2z 246 6 , , , cord-299949-kmn53e2z 246 7 2013 2013 CD cord-299949-kmn53e2z 246 8 ; ; : cord-299949-kmn53e2z 246 9 Gil Gil NNP cord-299949-kmn53e2z 246 10 - - HYPH cord-299949-kmn53e2z 246 11 Cruz Cruz NNP cord-299949-kmn53e2z 246 12 and and CC cord-299949-kmn53e2z 246 13 Perez Perez NNP cord-299949-kmn53e2z 246 14 - - HYPH cord-299949-kmn53e2z 246 15 Shibayama Shibayama NNP cord-299949-kmn53e2z 246 16 , , , cord-299949-kmn53e2z 246 17 2012 2012 CD cord-299949-kmn53e2z 246 18 ; ; : cord-299949-kmn53e2z 246 19 Marques Marques NNP cord-299949-kmn53e2z 246 20 et et NNP cord-299949-kmn53e2z 246 21 al al NNP cord-299949-kmn53e2z 246 22 . . NNP cord-299949-kmn53e2z 246 23 , , , cord-299949-kmn53e2z 246 24 2011 2011 CD cord-299949-kmn53e2z 246 25 ) ) -RRB- cord-299949-kmn53e2z 246 26 . . . cord-299949-kmn53e2z 247 1 CXCL10 CXCL10 NNP cord-299949-kmn53e2z 247 2 is be VBZ cord-299949-kmn53e2z 247 3 also also RB cord-299949-kmn53e2z 247 4 elevated elevate VBN cord-299949-kmn53e2z 247 5 during during IN cord-299949-kmn53e2z 247 6 SINV SINV NNP cord-299949-kmn53e2z 247 7 , , , cord-299949-kmn53e2z 247 8 TMEV TMEV NNP cord-299949-kmn53e2z 247 9 , , , cord-299949-kmn53e2z 247 10 and and CC cord-299949-kmn53e2z 247 11 rabies rabies NN cord-299949-kmn53e2z 247 12 virus virus NN cord-299949-kmn53e2z 247 13 infections infection NNS cord-299949-kmn53e2z 247 14 , , , cord-299949-kmn53e2z 247 15 although although IN cord-299949-kmn53e2z 247 16 its -PRON- PRP$ cord-299949-kmn53e2z 247 17 role role NN cord-299949-kmn53e2z 247 18 in in IN cord-299949-kmn53e2z 247 19 ASC ASC NNP cord-299949-kmn53e2z 247 20 recruitment recruitment NN cord-299949-kmn53e2z 247 21 has have VBZ cord-299949-kmn53e2z 247 22 not not RB cord-299949-kmn53e2z 247 23 been be VBN cord-299949-kmn53e2z 247 24 defined define VBN cord-299949-kmn53e2z 247 25 ( ( -LRB- cord-299949-kmn53e2z 247 26 Rainey Rainey NNP cord-299949-kmn53e2z 247 27 - - HYPH cord-299949-kmn53e2z 247 28 Barger Barger NNP cord-299949-kmn53e2z 247 29 et et NNP cord-299949-kmn53e2z 247 30 al al NNP cord-299949-kmn53e2z 247 31 . . NNP cord-299949-kmn53e2z 247 32 , , , cord-299949-kmn53e2z 247 33 2011 2011 CD cord-299949-kmn53e2z 247 34 ; ; : cord-299949-kmn53e2z 247 35 Kuang Kuang NNP cord-299949-kmn53e2z 247 36 et et NNP cord-299949-kmn53e2z 247 37 al al NNP cord-299949-kmn53e2z 247 38 . . NNP cord-299949-kmn53e2z 247 39 , , , cord-299949-kmn53e2z 247 40 2009 2009 CD cord-299949-kmn53e2z 247 41 ; ; . cord-299949-kmn53e2z 248 1 Phares Phares NNP cord-299949-kmn53e2z 248 2 et et NNP cord-299949-kmn53e2z 248 3 al al NNP cord-299949-kmn53e2z 248 4 . . NNP cord-299949-kmn53e2z 248 5 , , , cord-299949-kmn53e2z 248 6 2006 2006 CD cord-299949-kmn53e2z 248 7 ; ; : cord-299949-kmn53e2z 248 8 Hoffman Hoffman NNP cord-299949-kmn53e2z 248 9 et et NNP cord-299949-kmn53e2z 248 10 al al NNP cord-299949-kmn53e2z 248 11 . . NNP cord-299949-kmn53e2z 248 12 , , , cord-299949-kmn53e2z 248 13 1999 1999 CD cord-299949-kmn53e2z 248 14 ) ) -RRB- cord-299949-kmn53e2z 248 15 . . . cord-299949-kmn53e2z 249 1 Infiltrating infiltrate VBG cord-299949-kmn53e2z 249 2 B b NN cord-299949-kmn53e2z 249 3 cells cell NNS cord-299949-kmn53e2z 249 4 early early RB cord-299949-kmn53e2z 249 5 in in IN cord-299949-kmn53e2z 249 6 infection infection NN cord-299949-kmn53e2z 249 7 are be VBP cord-299949-kmn53e2z 249 8 naïve naïve JJ cord-299949-kmn53e2z 249 9 / / SYM cord-299949-kmn53e2z 249 10 early early RB cord-299949-kmn53e2z 249 11 activated activate VBN cord-299949-kmn53e2z 249 12 but but CC cord-299949-kmn53e2z 249 13 progress progress NN cord-299949-kmn53e2z 249 14 to to IN cord-299949-kmn53e2z 249 15 a a DT cord-299949-kmn53e2z 249 16 more more RBR cord-299949-kmn53e2z 249 17 differentiated differentiated JJ cord-299949-kmn53e2z 249 18 , , , cord-299949-kmn53e2z 249 19 isotype isotype NN cord-299949-kmn53e2z 249 20 - - HYPH cord-299949-kmn53e2z 249 21 switched switch VBN cord-299949-kmn53e2z 249 22 phenotype phenotype NN cord-299949-kmn53e2z 249 23 . . . cord-299949-kmn53e2z 250 1 Consequently consequently RB cord-299949-kmn53e2z 250 2 , , , cord-299949-kmn53e2z 250 3 ASC ASC NNP cord-299949-kmn53e2z 250 4 that that WDT cord-299949-kmn53e2z 250 5 first first RB cord-299949-kmn53e2z 250 6 enter enter VBP cord-299949-kmn53e2z 250 7 the the DT cord-299949-kmn53e2z 250 8 CNS CNS NNP cord-299949-kmn53e2z 250 9 produce produce VB cord-299949-kmn53e2z 250 10 IgM IgM NNP cord-299949-kmn53e2z 250 11 , , , cord-299949-kmn53e2z 250 12 likely likely RB cord-299949-kmn53e2z 250 13 contributing contribute VBG cord-299949-kmn53e2z 250 14 to to IN cord-299949-kmn53e2z 250 15 neutralization neutralization NN cord-299949-kmn53e2z 250 16 of of IN cord-299949-kmn53e2z 250 17 free free JJ cord-299949-kmn53e2z 250 18 virus virus NN cord-299949-kmn53e2z 250 19 . . . cord-299949-kmn53e2z 251 1 Through through IN cord-299949-kmn53e2z 251 2 the the DT cord-299949-kmn53e2z 251 3 course course NN cord-299949-kmn53e2z 251 4 of of IN cord-299949-kmn53e2z 251 5 infection infection NN cord-299949-kmn53e2z 251 6 , , , cord-299949-kmn53e2z 251 7 IgG IgG NNP cord-299949-kmn53e2z 251 8 predominates predominate VBZ cord-299949-kmn53e2z 251 9 with with IN cord-299949-kmn53e2z 251 10 IgA IgA NNP cord-299949-kmn53e2z 251 11 also also RB cord-299949-kmn53e2z 251 12 present present VBP cord-299949-kmn53e2z 251 13 and and CC cord-299949-kmn53e2z 251 14 declining decline VBG cord-299949-kmn53e2z 251 15 levels level NNS cord-299949-kmn53e2z 251 16 of of IN cord-299949-kmn53e2z 251 17 IgM IgM NNP cord-299949-kmn53e2z 252 1 ( ( -LRB- cord-299949-kmn53e2z 252 2 Phares Phares NNP cord-299949-kmn53e2z 252 3 et et NNP cord-299949-kmn53e2z 252 4 al al NNP cord-299949-kmn53e2z 252 5 . . NNP cord-299949-kmn53e2z 252 6 , , , cord-299949-kmn53e2z 252 7 2014 2014 CD cord-299949-kmn53e2z 252 8 ; ; : cord-299949-kmn53e2z 252 9 Metcalf Metcalf NNP cord-299949-kmn53e2z 252 10 and and CC cord-299949-kmn53e2z 252 11 Griffin Griffin NNP cord-299949-kmn53e2z 252 12 , , , cord-299949-kmn53e2z 252 13 2011 2011 CD cord-299949-kmn53e2z 252 14 ; ; : cord-299949-kmn53e2z 252 15 Tschen Tschen NNP cord-299949-kmn53e2z 252 16 et et NNP cord-299949-kmn53e2z 252 17 al al NNP cord-299949-kmn53e2z 252 18 . . NNP cord-299949-kmn53e2z 252 19 , , , cord-299949-kmn53e2z 252 20 2002 2002 CD cord-299949-kmn53e2z 252 21 ; ; : cord-299949-kmn53e2z 253 1 Tyor Tyor NNP cord-299949-kmn53e2z 253 2 and and CC cord-299949-kmn53e2z 253 3 Griffin Griffin NNP cord-299949-kmn53e2z 253 4 , , , cord-299949-kmn53e2z 253 5 1993 1993 CD cord-299949-kmn53e2z 253 6 ) ) -RRB- cord-299949-kmn53e2z 253 7 . . . cord-299949-kmn53e2z 254 1 Long long JJ cord-299949-kmn53e2z 254 2 - - HYPH cord-299949-kmn53e2z 254 3 term term NN cord-299949-kmn53e2z 254 4 expression expression NN cord-299949-kmn53e2z 254 5 of of IN cord-299949-kmn53e2z 254 6 B b NN cord-299949-kmn53e2z 254 7 cell cell NN cord-299949-kmn53e2z 254 8 activating activate VBG cord-299949-kmn53e2z 254 9 factor factor NN cord-299949-kmn53e2z 254 10 ( ( -LRB- cord-299949-kmn53e2z 254 11 BAFF BAFF NNP cord-299949-kmn53e2z 254 12 ) ) -RRB- cord-299949-kmn53e2z 254 13 and and CC cord-299949-kmn53e2z 254 14 a a DT cord-299949-kmn53e2z 254 15 proliferating proliferate VBG cord-299949-kmn53e2z 254 16 - - HYPH cord-299949-kmn53e2z 254 17 inducing induce VBG cord-299949-kmn53e2z 254 18 ligand ligand NN cord-299949-kmn53e2z 254 19 ( ( -LRB- cord-299949-kmn53e2z 254 20 APRIL APRIL NNP cord-299949-kmn53e2z 254 21 ) ) -RRB- cord-299949-kmn53e2z 254 22 in in IN cord-299949-kmn53e2z 254 23 the the DT cord-299949-kmn53e2z 254 24 brain brain NN cord-299949-kmn53e2z 255 1 likely likely JJ cord-299949-kmn53e2z 255 2 support support VB cord-299949-kmn53e2z 255 3 ASC ASC NNP cord-299949-kmn53e2z 255 4 survival survival NN cord-299949-kmn53e2z 255 5 ( ( -LRB- cord-299949-kmn53e2z 255 6 Metcalf Metcalf NNP cord-299949-kmn53e2z 255 7 et et NNP cord-299949-kmn53e2z 255 8 al al NNP cord-299949-kmn53e2z 255 9 . . NNP cord-299949-kmn53e2z 255 10 , , , cord-299949-kmn53e2z 255 11 2013 2013 CD cord-299949-kmn53e2z 255 12 ; ; : cord-299949-kmn53e2z 255 13 Metcalf Metcalf NNP cord-299949-kmn53e2z 255 14 and and CC cord-299949-kmn53e2z 255 15 Griffin Griffin NNP cord-299949-kmn53e2z 255 16 , , , cord-299949-kmn53e2z 255 17 2011 2011 CD cord-299949-kmn53e2z 255 18 ; ; : cord-299949-kmn53e2z 255 19 Phares Phares NNP cord-299949-kmn53e2z 255 20 et et NNP cord-299949-kmn53e2z 255 21 al al NNP cord-299949-kmn53e2z 255 22 . . NNP cord-299949-kmn53e2z 255 23 , , , cord-299949-kmn53e2z 255 24 2011 2011 CD cord-299949-kmn53e2z 255 25 ; ; : cord-299949-kmn53e2z 255 26 Tschen Tschen NNP cord-299949-kmn53e2z 255 27 et et NNP cord-299949-kmn53e2z 255 28 al al NNP cord-299949-kmn53e2z 255 29 . . NNP cord-299949-kmn53e2z 255 30 , , , cord-299949-kmn53e2z 255 31 2006 2006 CD cord-299949-kmn53e2z 255 32 ) ) -RRB- cord-299949-kmn53e2z 255 33 . . . cord-299949-kmn53e2z 256 1 CD4 CD4 NNP cord-299949-kmn53e2z 256 2 þ þ NNP cord-299949-kmn53e2z 256 3 and and CC cord-299949-kmn53e2z 256 4 CD8 CD8 NNP cord-299949-kmn53e2z 256 5 þ þ NNP cord-299949-kmn53e2z 256 6 T T NNP cord-299949-kmn53e2z 256 7 cells cell NNS cord-299949-kmn53e2z 256 8 are be VBP cord-299949-kmn53e2z 256 9 also also RB cord-299949-kmn53e2z 256 10 retained retain VBN cord-299949-kmn53e2z 256 11 in in IN cord-299949-kmn53e2z 256 12 the the DT cord-299949-kmn53e2z 256 13 CNS CNS NNP cord-299949-kmn53e2z 256 14 after after IN cord-299949-kmn53e2z 256 15 virus virus NN cord-299949-kmn53e2z 256 16 infection infection NN cord-299949-kmn53e2z 256 17 ( ( -LRB- cord-299949-kmn53e2z 256 18 Metcalf Metcalf NNP cord-299949-kmn53e2z 256 19 and and CC cord-299949-kmn53e2z 256 20 Griffin Griffin NNP cord-299949-kmn53e2z 256 21 , , , cord-299949-kmn53e2z 256 22 2011 2011 CD cord-299949-kmn53e2z 256 23 ; ; : cord-299949-kmn53e2z 256 24 Stewart Stewart NNP cord-299949-kmn53e2z 256 25 et et NNP cord-299949-kmn53e2z 256 26 al al NNP cord-299949-kmn53e2z 256 27 . . NNP cord-299949-kmn53e2z 256 28 , , , cord-299949-kmn53e2z 256 29 2011 2011 CD cord-299949-kmn53e2z 256 30 ; ; : cord-299949-kmn53e2z 257 1 Wakim Wakim NNP cord-299949-kmn53e2z 257 2 et et NNP cord-299949-kmn53e2z 257 3 al al NNP cord-299949-kmn53e2z 257 4 . . NNP cord-299949-kmn53e2z 257 5 , , , cord-299949-kmn53e2z 257 6 2010 2010 CD cord-299949-kmn53e2z 257 7 ) ) -RRB- cord-299949-kmn53e2z 257 8 . . . cord-299949-kmn53e2z 258 1 Antigen antigen NN cord-299949-kmn53e2z 258 2 - - HYPH cord-299949-kmn53e2z 258 3 mediated mediate VBN cord-299949-kmn53e2z 258 4 upregulation upregulation NN cord-299949-kmn53e2z 258 5 of of IN cord-299949-kmn53e2z 258 6 the the DT cord-299949-kmn53e2z 258 7 adhesion adhesion NN cord-299949-kmn53e2z 258 8 molecule molecule NN cord-299949-kmn53e2z 258 9 CD103 CD103 NNP cord-299949-kmn53e2z 258 10 on on IN cord-299949-kmn53e2z 258 11 infiltrating infiltrate VBG cord-299949-kmn53e2z 258 12 effector effector JJ cord-299949-kmn53e2z 258 13 CD8 CD8 NNP cord-299949-kmn53e2z 258 14 þ þ NNP cord-299949-kmn53e2z 258 15 T T NNP cord-299949-kmn53e2z 258 16 cells cell NNS cord-299949-kmn53e2z 258 17 leads lead VBZ cord-299949-kmn53e2z 258 18 to to IN cord-299949-kmn53e2z 258 19 prolonged prolonged JJ cord-299949-kmn53e2z 258 20 retention retention NN cord-299949-kmn53e2z 258 21 of of IN cord-299949-kmn53e2z 258 22 T t NN cord-299949-kmn53e2z 258 23 cell cell NN cord-299949-kmn53e2z 258 24 clusters cluster NNS cord-299949-kmn53e2z 258 25 after after IN cord-299949-kmn53e2z 258 26 infection infection NN cord-299949-kmn53e2z 258 27 ( ( -LRB- cord-299949-kmn53e2z 259 1 Wakim Wakim NNP cord-299949-kmn53e2z 259 2 et et NNP cord-299949-kmn53e2z 259 3 al al NNP cord-299949-kmn53e2z 259 4 . . NNP cord-299949-kmn53e2z 259 5 , , , cord-299949-kmn53e2z 259 6 2010 2010 CD cord-299949-kmn53e2z 259 7 ) ) -RRB- cord-299949-kmn53e2z 259 8 . . . cord-299949-kmn53e2z 260 1 Together together RB cord-299949-kmn53e2z 260 2 , , , cord-299949-kmn53e2z 260 3 B b NN cord-299949-kmn53e2z 260 4 cells cell NNS cord-299949-kmn53e2z 260 5 and and CC cord-299949-kmn53e2z 260 6 T t NN cord-299949-kmn53e2z 260 7 cells cell NNS cord-299949-kmn53e2z 260 8 retained retain VBN cord-299949-kmn53e2z 260 9 in in IN cord-299949-kmn53e2z 260 10 the the DT cord-299949-kmn53e2z 260 11 CNS CNS NNP cord-299949-kmn53e2z 260 12 after after IN cord-299949-kmn53e2z 260 13 infection infection NN cord-299949-kmn53e2z 260 14 suppress suppress VBP cord-299949-kmn53e2z 260 15 reactivation reactivation NN cord-299949-kmn53e2z 260 16 of of IN cord-299949-kmn53e2z 260 17 virus virus NN cord-299949-kmn53e2z 260 18 replication replication NN cord-299949-kmn53e2z 260 19 by by IN cord-299949-kmn53e2z 260 20 residual residual JJ cord-299949-kmn53e2z 260 21 viral viral JJ cord-299949-kmn53e2z 260 22 RNA RNA NNP cord-299949-kmn53e2z 260 23 . . . cord-299949-kmn53e2z 260 24 _SP cord-299949-kmn53e2z 261 1 Persistence persistence NN cord-299949-kmn53e2z 261 2 of of IN cord-299949-kmn53e2z 261 3 West West NNP cord-299949-kmn53e2z 261 4 Nile Nile NNP cord-299949-kmn53e2z 261 5 virus virus NN cord-299949-kmn53e2z 261 6 in in IN cord-299949-kmn53e2z 261 7 the the DT cord-299949-kmn53e2z 261 8 central central JJ cord-299949-kmn53e2z 261 9 nervous nervous JJ cord-299949-kmn53e2z 261 10 system system NN cord-299949-kmn53e2z 261 11 and and CC cord-299949-kmn53e2z 261 12 periphery periphery NN cord-299949-kmn53e2z 261 13 of of IN cord-299949-kmn53e2z 261 14 mice mouse NNS cord-299949-kmn53e2z 262 1 Up up IN cord-299949-kmn53e2z 262 2 - - HYPH cord-299949-kmn53e2z 262 3 regulation regulation NN cord-299949-kmn53e2z 262 4 of of IN cord-299949-kmn53e2z 262 5 fas fas NNP cord-299949-kmn53e2z 262 6 ligand ligand NNP cord-299949-kmn53e2z 262 7 ( ( -LRB- cord-299949-kmn53e2z 262 8 FasL FasL NNP cord-299949-kmn53e2z 262 9 ) ) -RRB- cord-299949-kmn53e2z 262 10 in in IN cord-299949-kmn53e2z 262 11 the the DT cord-299949-kmn53e2z 262 12 central central JJ cord-299949-kmn53e2z 262 13 nervous nervous JJ cord-299949-kmn53e2z 262 14 system system NN cord-299949-kmn53e2z 262 15 : : : cord-299949-kmn53e2z 262 16 a a DT cord-299949-kmn53e2z 262 17 mechanism mechanism NN cord-299949-kmn53e2z 262 18 of of IN cord-299949-kmn53e2z 262 19 immune immune JJ cord-299949-kmn53e2z 262 20 evasion evasion NN cord-299949-kmn53e2z 262 21 by by IN cord-299949-kmn53e2z 262 22 rabies rabies NN cord-299949-kmn53e2z 262 23 virus virus NN cord-299949-kmn53e2z 263 1 The the DT cord-299949-kmn53e2z 263 2 olfactory olfactory JJ cord-299949-kmn53e2z 263 3 nerve nerve NN cord-299949-kmn53e2z 263 4 and and CC cord-299949-kmn53e2z 263 5 not not RB cord-299949-kmn53e2z 263 6 the the DT cord-299949-kmn53e2z 263 7 trigeminal trigeminal JJ cord-299949-kmn53e2z 263 8 nerve nerve NN cord-299949-kmn53e2z 263 9 is be VBZ cord-299949-kmn53e2z 263 10 the the DT cord-299949-kmn53e2z 263 11 major major JJ cord-299949-kmn53e2z 263 12 site site NN cord-299949-kmn53e2z 263 13 of of IN cord-299949-kmn53e2z 263 14 CNS CNS NNP cord-299949-kmn53e2z 263 15 entry entry NN cord-299949-kmn53e2z 263 16 for for IN cord-299949-kmn53e2z 263 17 mouse mouse NN cord-299949-kmn53e2z 263 18 hepatitis hepatitis NNP cord-299949-kmn53e2z 263 19 virus virus NN cord-299949-kmn53e2z 263 20 La La NNP cord-299949-kmn53e2z 263 21 Crosse Crosse NNP cord-299949-kmn53e2z 263 22 virus virus NN cord-299949-kmn53e2z 263 23 infectivity infectivity NN cord-299949-kmn53e2z 263 24 , , , cord-299949-kmn53e2z 263 25 pathogenesis pathogenesis NN cord-299949-kmn53e2z 263 26 , , , cord-299949-kmn53e2z 263 27 and and CC cord-299949-kmn53e2z 263 28 immunogenicity immunogenicity NN cord-299949-kmn53e2z 263 29 in in IN cord-299949-kmn53e2z 263 30 mice mouse NNS cord-299949-kmn53e2z 263 31 and and CC cord-299949-kmn53e2z 263 32 monkeys monkey NNS cord-299949-kmn53e2z 263 33 Inverted invert VBN cord-299949-kmn53e2z 263 34 immunodominance immunodominance NN cord-299949-kmn53e2z 263 35 and and CC cord-299949-kmn53e2z 263 36 impaired impair VBN cord-299949-kmn53e2z 263 37 cytolytic cytolytic JJ cord-299949-kmn53e2z 263 38 function function NN cord-299949-kmn53e2z 263 39 of of IN cord-299949-kmn53e2z 263 40 CD8 CD8 NNP cord-299949-kmn53e2z 263 41 þ þ NNP cord-299949-kmn53e2z 263 42 T T NNP cord-299949-kmn53e2z 263 43 cells cell NNS cord-299949-kmn53e2z 263 44 during during IN cord-299949-kmn53e2z 263 45 viral viral JJ cord-299949-kmn53e2z 263 46 persistence persistence NN cord-299949-kmn53e2z 263 47 in in IN cord-299949-kmn53e2z 263 48 the the DT cord-299949-kmn53e2z 263 49 central central JJ cord-299949-kmn53e2z 263 50 nervous nervous JJ cord-299949-kmn53e2z 263 51 system system NN cord-299949-kmn53e2z 263 52 Perforin Perforin NNP cord-299949-kmn53e2z 263 53 - - HYPH cord-299949-kmn53e2z 263 54 mediated mediate VBN cord-299949-kmn53e2z 263 55 effector effector NN cord-299949-kmn53e2z 263 56 function function NN cord-299949-kmn53e2z 263 57 within within IN cord-299949-kmn53e2z 263 58 the the DT cord-299949-kmn53e2z 263 59 central central JJ cord-299949-kmn53e2z 263 60 nervous nervous JJ cord-299949-kmn53e2z 263 61 system system NN cord-299949-kmn53e2z 264 1 requires require VBZ cord-299949-kmn53e2z 264 2 IFN IFN NNP cord-299949-kmn53e2z 264 3 -- -- : cord-299949-kmn53e2z 264 4 mediated mediate VBD cord-299949-kmn53e2z 264 5 MHC MHC NNP cord-299949-kmn53e2z 264 6 up up IN cord-299949-kmn53e2z 264 7 - - HYPH cord-299949-kmn53e2z 264 8 regulation regulation NN cord-299949-kmn53e2z 264 9 Perforin Perforin NNP cord-299949-kmn53e2z 264 10 and and CC cord-299949-kmn53e2z 264 11 gamma gamma NN cord-299949-kmn53e2z 264 12 interferon interferon NN cord-299949-kmn53e2z 264 13 - - HYPH cord-299949-kmn53e2z 264 14 mediated mediate VBN cord-299949-kmn53e2z 264 15 control control NN cord-299949-kmn53e2z 264 16 of of IN cord-299949-kmn53e2z 264 17 coronavirus coronavirus NN cord-299949-kmn53e2z 264 18 central central JJ cord-299949-kmn53e2z 264 19 nervous nervous JJ cord-299949-kmn53e2z 264 20 system system NN cord-299949-kmn53e2z 264 21 infection infection NN cord-299949-kmn53e2z 264 22 by by IN cord-299949-kmn53e2z 264 23 CD8 CD8 NNP cord-299949-kmn53e2z 264 24 T T NNP cord-299949-kmn53e2z 264 25 cells cell NNS cord-299949-kmn53e2z 264 26 in in IN cord-299949-kmn53e2z 264 27 the the DT cord-299949-kmn53e2z 264 28 absence absence NN cord-299949-kmn53e2z 264 29 of of IN cord-299949-kmn53e2z 264 30 CD4 CD4 NNP cord-299949-kmn53e2z 264 31 T T NNP cord-299949-kmn53e2z 264 32 cells cell NNS cord-299949-kmn53e2z 264 33 Interferon interferon NN cord-299949-kmn53e2z 264 34 - - HYPH cord-299949-kmn53e2z 264 35 gamma gamma NN cord-299949-kmn53e2z 264 36 - - HYPH cord-299949-kmn53e2z 264 37 mediated mediate VBN cord-299949-kmn53e2z 264 38 site site NN cord-299949-kmn53e2z 264 39 - - HYPH cord-299949-kmn53e2z 264 40 specific specific JJ cord-299949-kmn53e2z 264 41 clearance clearance NN cord-299949-kmn53e2z 264 42 of of IN cord-299949-kmn53e2z 264 43 alphavirus alphavirus NN cord-299949-kmn53e2z 264 44 from from IN cord-299949-kmn53e2z 264 45 CNS CNS NNP cord-299949-kmn53e2z 264 46 neurons neuron NNS cord-299949-kmn53e2z 265 1 Gamma gamma NN cord-299949-kmn53e2z 265 2 interferon interferon NN cord-299949-kmn53e2z 265 3 - - HYPH cord-299949-kmn53e2z 265 4 dependent dependent JJ cord-299949-kmn53e2z 265 5 , , , cord-299949-kmn53e2z 265 6 noncytolytic noncytolytic JJ cord-299949-kmn53e2z 265 7 clearance clearance NN cord-299949-kmn53e2z 265 8 of of IN cord-299949-kmn53e2z 265 9 sindbis sindbis NNP cord-299949-kmn53e2z 265 10 virus virus NN cord-299949-kmn53e2z 265 11 infection infection NN cord-299949-kmn53e2z 265 12 from from IN cord-299949-kmn53e2z 265 13 neurons neuron NNS cord-299949-kmn53e2z 265 14 in in IN cord-299949-kmn53e2z 265 15 vitro vitro FW cord-299949-kmn53e2z 265 16 Control Control NNP cord-299949-kmn53e2z 265 17 of of IN cord-299949-kmn53e2z 265 18 sindbis sindbis NNP cord-299949-kmn53e2z 265 19 virus virus NN cord-299949-kmn53e2z 265 20 infection infection NN cord-299949-kmn53e2z 265 21 by by IN cord-299949-kmn53e2z 265 22 antibody antibody NN cord-299949-kmn53e2z 265 23 in in IN cord-299949-kmn53e2z 265 24 interferon interferon NN cord-299949-kmn53e2z 265 25 - - HYPH cord-299949-kmn53e2z 265 26 deficient deficient JJ cord-299949-kmn53e2z 265 27 mice mouse NNS cord-299949-kmn53e2z 265 28 Maturation maturation NN cord-299949-kmn53e2z 265 29 - - HYPH cord-299949-kmn53e2z 265 30 dependent dependent JJ cord-299949-kmn53e2z 265 31 responses response NNS cord-299949-kmn53e2z 265 32 of of IN cord-299949-kmn53e2z 265 33 human human JJ cord-299949-kmn53e2z 265 34 neuronal neuronal JJ cord-299949-kmn53e2z 265 35 cells cell NNS cord-299949-kmn53e2z 265 36 to to IN cord-299949-kmn53e2z 265 37 western western JJ cord-299949-kmn53e2z 265 38 equine equine JJ cord-299949-kmn53e2z 265 39 encephalitis encephalitis NN cord-299949-kmn53e2z 265 40 virus virus NN cord-299949-kmn53e2z 265 41 infection infection NN cord-299949-kmn53e2z 265 42 and and CC cord-299949-kmn53e2z 265 43 type type NN cord-299949-kmn53e2z 265 44 I -PRON- PRP cord-299949-kmn53e2z 265 45 interferons interferon NNS cord-299949-kmn53e2z 265 46 Neurons neuron NNS cord-299949-kmn53e2z 265 47 under under IN cord-299949-kmn53e2z 265 48 viral viral JJ cord-299949-kmn53e2z 265 49 attack attack NN cord-299949-kmn53e2z 265 50 : : : cord-299949-kmn53e2z 265 51 victims victim NNS cord-299949-kmn53e2z 265 52 or or CC cord-299949-kmn53e2z 265 53 warriors warrior NNS cord-299949-kmn53e2z 265 54 ? ? . cord-299949-kmn53e2z 266 1 Differential differential JJ cord-299949-kmn53e2z 266 2 expression expression NN cord-299949-kmn53e2z 266 3 of of IN cord-299949-kmn53e2z 266 4 TGF TGF NNP cord-299949-kmn53e2z 266 5 - - HYPH cord-299949-kmn53e2z 266 6 b b NNP cord-299949-kmn53e2z 266 7 , , , cord-299949-kmn53e2z 266 8 IL-2 IL-2 NNP cord-299949-kmn53e2z 266 9 , , , cord-299949-kmn53e2z 266 10 and and CC cord-299949-kmn53e2z 266 11 other other JJ cord-299949-kmn53e2z 266 12 cytokines cytokine NNS cord-299949-kmn53e2z 266 13 in in IN cord-299949-kmn53e2z 266 14 the the DT cord-299949-kmn53e2z 266 15 CNS CNS NNP cord-299949-kmn53e2z 266 16 of of IN cord-299949-kmn53e2z 266 17 Theiler Theiler NNP cord-299949-kmn53e2z 266 18 's 's POS cord-299949-kmn53e2z 266 19 murine murine JJ cord-299949-kmn53e2z 266 20 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 266 21 virus virus NN cord-299949-kmn53e2z 266 22 - - HYPH cord-299949-kmn53e2z 266 23 infected infect VBN cord-299949-kmn53e2z 266 24 susceptible susceptible JJ cord-299949-kmn53e2z 266 25 and and CC cord-299949-kmn53e2z 266 26 resistant resistant JJ cord-299949-kmn53e2z 266 27 strains strain NNS cord-299949-kmn53e2z 266 28 of of IN cord-299949-kmn53e2z 266 29 mice mouse NNS cord-299949-kmn53e2z 266 30 Mechanism Mechanism NNP cord-299949-kmn53e2z 266 31 of of IN cord-299949-kmn53e2z 266 32 neuroinvasion neuroinvasion NN cord-299949-kmn53e2z 266 33 of of IN cord-299949-kmn53e2z 266 34 venezuelan venezuelan JJ cord-299949-kmn53e2z 266 35 equine equine NN cord-299949-kmn53e2z 266 36 encephalitis encephalitis NN cord-299949-kmn53e2z 266 37 virus virus NN cord-299949-kmn53e2z 266 38 in in IN cord-299949-kmn53e2z 266 39 the the DT cord-299949-kmn53e2z 266 40 mouse mouse NN cord-299949-kmn53e2z 266 41 Neuronal neuronal JJ cord-299949-kmn53e2z 266 42 influence influence NN cord-299949-kmn53e2z 266 43 behind behind IN cord-299949-kmn53e2z 266 44 the the DT cord-299949-kmn53e2z 266 45 central central JJ cord-299949-kmn53e2z 266 46 nervous nervous JJ cord-299949-kmn53e2z 266 47 system system NN cord-299949-kmn53e2z 266 48 regulation regulation NN cord-299949-kmn53e2z 266 49 of of IN cord-299949-kmn53e2z 266 50 the the DT cord-299949-kmn53e2z 266 51 immune immune JJ cord-299949-kmn53e2z 266 52 cells cell NNS cord-299949-kmn53e2z 267 1 Neurons neuron NNS cord-299949-kmn53e2z 267 2 are be VBP cord-299949-kmn53e2z 267 3 MHC MHC NNP cord-299949-kmn53e2z 267 4 class class NN cord-299949-kmn53e2z 267 5 i i NN cord-299949-kmn53e2z 267 6 - - HYPH cord-299949-kmn53e2z 267 7 dependent dependent JJ cord-299949-kmn53e2z 267 8 targets target NNS cord-299949-kmn53e2z 267 9 for for IN cord-299949-kmn53e2z 267 10 CD8 CD8 NNP cord-299949-kmn53e2z 267 11 T T NNP cord-299949-kmn53e2z 267 12 cells cell NNS cord-299949-kmn53e2z 267 13 upon upon IN cord-299949-kmn53e2z 267 14 neurotropic neurotropic NNP cord-299949-kmn53e2z 267 15 viral viral JJ cord-299949-kmn53e2z 267 16 infection infection NN cord-299949-kmn53e2z 268 1 Differential differential JJ cord-299949-kmn53e2z 268 2 innate innate JJ cord-299949-kmn53e2z 268 3 immune immune JJ cord-299949-kmn53e2z 268 4 response response NN cord-299949-kmn53e2z 268 5 programs program NNS cord-299949-kmn53e2z 268 6 in in IN cord-299949-kmn53e2z 268 7 neuronal neuronal JJ cord-299949-kmn53e2z 268 8 subtypes subtype NNS cord-299949-kmn53e2z 268 9 determine determine VBP cord-299949-kmn53e2z 268 10 susceptibility susceptibility NN cord-299949-kmn53e2z 268 11 to to IN cord-299949-kmn53e2z 268 12 infection infection NN cord-299949-kmn53e2z 268 13 in in IN cord-299949-kmn53e2z 268 14 the the DT cord-299949-kmn53e2z 268 15 brain brain NN cord-299949-kmn53e2z 268 16 by by IN cord-299949-kmn53e2z 268 17 positive positive JJ cord-299949-kmn53e2z 268 18 - - HYPH cord-299949-kmn53e2z 268 19 stranded strand VBN cord-299949-kmn53e2z 268 20 RNA RNA NNP cord-299949-kmn53e2z 268 21 viruses virus NNS cord-299949-kmn53e2z 268 22 A a DT cord-299949-kmn53e2z 268 23 role role NN cord-299949-kmn53e2z 268 24 for for IN cord-299949-kmn53e2z 268 25 Ifit2 Ifit2 NNP cord-299949-kmn53e2z 268 26 in in IN cord-299949-kmn53e2z 268 27 restricting restrict VBG cord-299949-kmn53e2z 268 28 West West NNP cord-299949-kmn53e2z 268 29 Nile Nile NNP cord-299949-kmn53e2z 268 30 virus virus NN cord-299949-kmn53e2z 268 31 infection infection NN cord-299949-kmn53e2z 268 32 in in IN cord-299949-kmn53e2z 268 33 the the DT cord-299949-kmn53e2z 268 34 brain brain NN cord-299949-kmn53e2z 268 35 Structural structural JJ cord-299949-kmn53e2z 268 36 and and CC cord-299949-kmn53e2z 268 37 molecular molecular JJ cord-299949-kmn53e2z 268 38 interrogation interrogation NN cord-299949-kmn53e2z 268 39 of of IN cord-299949-kmn53e2z 268 40 intact intact JJ cord-299949-kmn53e2z 268 41 biological biological JJ cord-299949-kmn53e2z 268 42 systems system NNS cord-299949-kmn53e2z 268 43 Cell cell NN cord-299949-kmn53e2z 268 44 - - HYPH cord-299949-kmn53e2z 268 45 specific specific JJ cord-299949-kmn53e2z 268 46 IRF-3 IRF-3 NNP cord-299949-kmn53e2z 268 47 responses response NNS cord-299949-kmn53e2z 268 48 protect protect VBP cord-299949-kmn53e2z 268 49 against against IN cord-299949-kmn53e2z 268 50 West West NNP cord-299949-kmn53e2z 268 51 Nile Nile NNP cord-299949-kmn53e2z 268 52 virus virus NN cord-299949-kmn53e2z 268 53 infection infection NN cord-299949-kmn53e2z 268 54 by by IN cord-299949-kmn53e2z 268 55 interferon interferon NN cord-299949-kmn53e2z 268 56 - - HYPH cord-299949-kmn53e2z 268 57 dependent dependent JJ cord-299949-kmn53e2z 268 58 and and CC cord-299949-kmn53e2z 268 59 -independent -independent JJ cord-299949-kmn53e2z 268 60 mechanisms mechanism NNS cord-299949-kmn53e2z 268 61 Toll toll NN cord-299949-kmn53e2z 268 62 - - HYPH cord-299949-kmn53e2z 268 63 like like JJ cord-299949-kmn53e2z 268 64 receptor receptor NN cord-299949-kmn53e2z 268 65 3 3 CD cord-299949-kmn53e2z 268 66 has have VBZ cord-299949-kmn53e2z 268 67 a a DT cord-299949-kmn53e2z 268 68 protective protective JJ cord-299949-kmn53e2z 268 69 role role NN cord-299949-kmn53e2z 268 70 against against IN cord-299949-kmn53e2z 268 71 West West NNP cord-299949-kmn53e2z 268 72 Nile Nile NNP cord-299949-kmn53e2z 268 73 virus virus NN cord-299949-kmn53e2z 268 74 infection infection NN cord-299949-kmn53e2z 269 1 Interferon interferon NN cord-299949-kmn53e2z 269 2 regulatory regulatory JJ cord-299949-kmn53e2z 269 3 factor factor NN cord-299949-kmn53e2z 270 1 IRF-7 IRF-7 NNP cord-299949-kmn53e2z 270 2 induces induce VBZ cord-299949-kmn53e2z 270 3 the the DT cord-299949-kmn53e2z 270 4 antiviral antiviral JJ cord-299949-kmn53e2z 270 5 alpha alpha NN cord-299949-kmn53e2z 270 6 interferon interferon NN cord-299949-kmn53e2z 270 7 response response NN cord-299949-kmn53e2z 270 8 and and CC cord-299949-kmn53e2z 270 9 protects protect VBZ cord-299949-kmn53e2z 270 10 against against IN cord-299949-kmn53e2z 270 11 lethal lethal JJ cord-299949-kmn53e2z 270 12 West West NNP cord-299949-kmn53e2z 270 13 Nile Nile NNP cord-299949-kmn53e2z 270 14 virus virus NN cord-299949-kmn53e2z 270 15 infection infection NN cord-299949-kmn53e2z 270 16 Neurons neuron NNS cord-299949-kmn53e2z 270 17 produce produce VBP cord-299949-kmn53e2z 270 18 type type NN cord-299949-kmn53e2z 270 19 I -PRON- PRP cord-299949-kmn53e2z 270 20 interferon interferon VBD cord-299949-kmn53e2z 270 21 during during IN cord-299949-kmn53e2z 270 22 viral viral JJ cord-299949-kmn53e2z 270 23 encephalitis encephalitis NN cord-299949-kmn53e2z 270 24 Antiviral antiviral JJ cord-299949-kmn53e2z 270 25 activity activity NN cord-299949-kmn53e2z 270 26 of of IN cord-299949-kmn53e2z 270 27 alpha alpha NN cord-299949-kmn53e2z 270 28 interferon interferon NN cord-299949-kmn53e2z 270 29 in in IN cord-299949-kmn53e2z 270 30 sindbis sindbis NNP cord-299949-kmn53e2z 270 31 virus virus NN cord-299949-kmn53e2z 270 32 - - HYPH cord-299949-kmn53e2z 270 33 infected infect VBN cord-299949-kmn53e2z 270 34 cells cell NNS cord-299949-kmn53e2z 270 35 is be VBZ cord-299949-kmn53e2z 270 36 restored restore VBN cord-299949-kmn53e2z 270 37 by by IN cord-299949-kmn53e2z 270 38 anti anti JJ cord-299949-kmn53e2z 270 39 - - JJ cord-299949-kmn53e2z 270 40 E2 e2 JJ cord-299949-kmn53e2z 270 41 monoclonal monoclonal JJ cord-299949-kmn53e2z 270 42 antibody antibody NN cord-299949-kmn53e2z 270 43 treatment treatment NN cord-299949-kmn53e2z 270 44 Effects effect NNS cord-299949-kmn53e2z 270 45 of of IN cord-299949-kmn53e2z 270 46 anti anti JJ cord-299949-kmn53e2z 270 47 - - JJ cord-299949-kmn53e2z 270 48 E2 e2 JJ cord-299949-kmn53e2z 270 49 monoclonal monoclonal JJ cord-299949-kmn53e2z 270 50 antibody antibody NN cord-299949-kmn53e2z 270 51 on on IN cord-299949-kmn53e2z 270 52 sindbis sindbis NNP cord-299949-kmn53e2z 270 53 virus virus NN cord-299949-kmn53e2z 270 54 replication replication NN cord-299949-kmn53e2z 270 55 in in IN cord-299949-kmn53e2z 270 56 AT3 at3 NN cord-299949-kmn53e2z 270 57 cells cell NNS cord-299949-kmn53e2z 270 58 expressing express VBG cord-299949-kmn53e2z 270 59 Bcl-2 Bcl-2 NNP cord-299949-kmn53e2z 270 60 A a DT cord-299949-kmn53e2z 270 61 critical critical JJ cord-299949-kmn53e2z 270 62 role role NN cord-299949-kmn53e2z 270 63 for for IN cord-299949-kmn53e2z 270 64 induced induce VBN cord-299949-kmn53e2z 270 65 IgM IgM NNP cord-299949-kmn53e2z 270 66 in in IN cord-299949-kmn53e2z 270 67 the the DT cord-299949-kmn53e2z 270 68 Protection Protection NNP cord-299949-kmn53e2z 270 69 against against IN cord-299949-kmn53e2z 270 70 West West NNP cord-299949-kmn53e2z 270 71 Nile Nile NNP cord-299949-kmn53e2z 270 72 virus virus NN cord-299949-kmn53e2z 270 73 infection infection NN cord-299949-kmn53e2z 270 74 Cell cell NN cord-299949-kmn53e2z 270 75 - - HYPH cord-299949-kmn53e2z 270 76 intrinsic intrinsic JJ cord-299949-kmn53e2z 270 77 innate innate JJ cord-299949-kmn53e2z 270 78 immune immune JJ cord-299949-kmn53e2z 270 79 control control NN cord-299949-kmn53e2z 270 80 of of IN cord-299949-kmn53e2z 270 81 West West NNP cord-299949-kmn53e2z 270 82 Nile Nile NNP cord-299949-kmn53e2z 270 83 virus virus NN cord-299949-kmn53e2z 270 84 infection infection NN cord-299949-kmn53e2z 270 85 B b NN cord-299949-kmn53e2z 270 86 cells cell NNS cord-299949-kmn53e2z 270 87 and and CC cord-299949-kmn53e2z 270 88 antibody antibody NN cord-299949-kmn53e2z 270 89 play play VBP cord-299949-kmn53e2z 270 90 critical critical JJ cord-299949-kmn53e2z 270 91 roles role NNS cord-299949-kmn53e2z 270 92 in in IN cord-299949-kmn53e2z 270 93 the the DT cord-299949-kmn53e2z 270 94 immediate immediate JJ cord-299949-kmn53e2z 270 95 defense defense NN cord-299949-kmn53e2z 270 96 of of IN cord-299949-kmn53e2z 270 97 disseminated disseminate VBN cord-299949-kmn53e2z 270 98 infection infection NN cord-299949-kmn53e2z 270 99 by by IN cord-299949-kmn53e2z 270 100 West West NNP cord-299949-kmn53e2z 270 101 Nile Nile NNP cord-299949-kmn53e2z 270 102 encephalitis encephalitis NN cord-299949-kmn53e2z 270 103 virus virus NN cord-299949-kmn53e2z 270 104 IL-1R1 il-1r1 NN cord-299949-kmn53e2z 270 105 is be VBZ cord-299949-kmn53e2z 270 106 required require VBN cord-299949-kmn53e2z 270 107 for for IN cord-299949-kmn53e2z 270 108 dendritic dendritic JJ cord-299949-kmn53e2z 270 109 cellmediated cellmediate VBN cord-299949-kmn53e2z 270 110 T T NNP cord-299949-kmn53e2z 270 111 cell cell NN cord-299949-kmn53e2z 270 112 reactivation reactivation NN cord-299949-kmn53e2z 270 113 within within IN cord-299949-kmn53e2z 270 114 the the DT cord-299949-kmn53e2z 270 115 CNS CNS NNP cord-299949-kmn53e2z 270 116 during during IN cord-299949-kmn53e2z 270 117 West West NNP cord-299949-kmn53e2z 270 118 Nile Nile NNP cord-299949-kmn53e2z 270 119 virus virus NN cord-299949-kmn53e2z 270 120 encephalitis encephalitis RB cord-299949-kmn53e2z 271 1 Japanese japanese JJ cord-299949-kmn53e2z 271 2 encephalitis encephalitis RB cord-299949-kmn53e2z 271 3 virus virus NN cord-299949-kmn53e2z 271 4 infection infection NN cord-299949-kmn53e2z 271 5 induces induce VBZ cord-299949-kmn53e2z 271 6 IL-18 IL-18 NNP cord-299949-kmn53e2z 271 7 and and CC cord-299949-kmn53e2z 271 8 IL-1beta il-1beta NN cord-299949-kmn53e2z 271 9 in in IN cord-299949-kmn53e2z 271 10 microglia microglia NN cord-299949-kmn53e2z 271 11 and and CC cord-299949-kmn53e2z 271 12 astrocytes astrocyte NNS cord-299949-kmn53e2z 271 13 : : : cord-299949-kmn53e2z 271 14 correlation correlation NN cord-299949-kmn53e2z 271 15 with with IN cord-299949-kmn53e2z 271 16 in in FW cord-299949-kmn53e2z 271 17 vitro vitro FW cord-299949-kmn53e2z 271 18 cytokine cytokine JJ cord-299949-kmn53e2z 271 19 responsiveness responsiveness NN cord-299949-kmn53e2z 271 20 of of IN cord-299949-kmn53e2z 271 21 glial glial JJ cord-299949-kmn53e2z 271 22 cells cell NNS cord-299949-kmn53e2z 271 23 and and CC cord-299949-kmn53e2z 271 24 subsequent subsequent JJ cord-299949-kmn53e2z 271 25 neuronal neuronal JJ cord-299949-kmn53e2z 271 26 death death NN cord-299949-kmn53e2z 271 27 Major major JJ cord-299949-kmn53e2z 271 28 histocompatibility histocompatibility NN cord-299949-kmn53e2z 271 29 complex complex NN cord-299949-kmn53e2z 271 30 class class NN cord-299949-kmn53e2z 272 1 I -PRON- PRP cord-299949-kmn53e2z 272 2 proteins protein VBZ cord-299949-kmn53e2z 272 3 in in IN cord-299949-kmn53e2z 272 4 brain brain NN cord-299949-kmn53e2z 272 5 development development NN cord-299949-kmn53e2z 272 6 and and CC cord-299949-kmn53e2z 272 7 plasticity plasticity NN cord-299949-kmn53e2z 273 1 TGF TGF NNP cord-299949-kmn53e2z 273 2 - - HYPH cord-299949-kmn53e2z 273 3 Beta Beta NNP cord-299949-kmn53e2z 273 4 2 2 CD cord-299949-kmn53e2z 273 5 decreases decrease VBZ cord-299949-kmn53e2z 273 6 migration migration NN cord-299949-kmn53e2z 273 7 of of IN cord-299949-kmn53e2z 273 8 lymphocytes lymphocyte NNS cord-299949-kmn53e2z 273 9 in in IN cord-299949-kmn53e2z 273 10 vitro vitro FW cord-299949-kmn53e2z 273 11 and and CC cord-299949-kmn53e2z 273 12 homing homing NN cord-299949-kmn53e2z 273 13 of of IN cord-299949-kmn53e2z 273 14 cells cell NNS cord-299949-kmn53e2z 273 15 into into IN cord-299949-kmn53e2z 273 16 the the DT cord-299949-kmn53e2z 273 17 central central JJ cord-299949-kmn53e2z 273 18 nervous nervous JJ cord-299949-kmn53e2z 273 19 system system NN cord-299949-kmn53e2z 273 20 in in IN cord-299949-kmn53e2z 273 21 vivo vivo NNP cord-299949-kmn53e2z 273 22 Activation Activation NNP cord-299949-kmn53e2z 273 23 of of IN cord-299949-kmn53e2z 273 24 the the DT cord-299949-kmn53e2z 273 25 type type NN cord-299949-kmn53e2z 274 1 I -PRON- PRP cord-299949-kmn53e2z 274 2 interferon interferon VBD cord-299949-kmn53e2z 274 3 pathway pathway NN cord-299949-kmn53e2z 274 4 is be VBZ cord-299949-kmn53e2z 274 5 enhanced enhance VBN cord-299949-kmn53e2z 274 6 in in IN cord-299949-kmn53e2z 274 7 response response NN cord-299949-kmn53e2z 274 8 to to IN cord-299949-kmn53e2z 274 9 human human JJ cord-299949-kmn53e2z 274 10 neuronal neuronal JJ cord-299949-kmn53e2z 274 11 differentiation differentiation NN cord-299949-kmn53e2z 275 1 Western western JJ cord-299949-kmn53e2z 275 2 equine equine NN cord-299949-kmn53e2z 275 3 and and CC cord-299949-kmn53e2z 275 4 St. St. NNP cord-299949-kmn53e2z 275 5 Louis Louis NNP cord-299949-kmn53e2z 275 6 encephalitis encephalitis RB cord-299949-kmn53e2z 275 7 preliminary preliminary JJ cord-299949-kmn53e2z 275 8 report report NN cord-299949-kmn53e2z 275 9 of of IN cord-299949-kmn53e2z 275 10 a a DT cord-299949-kmn53e2z 275 11 clinical clinical JJ cord-299949-kmn53e2z 275 12 follow follow NN cord-299949-kmn53e2z 275 13 - - HYPH cord-299949-kmn53e2z 275 14 up up NN cord-299949-kmn53e2z 275 15 study study NN cord-299949-kmn53e2z 275 16 in in IN cord-299949-kmn53e2z 275 17 California California NNP cord-299949-kmn53e2z 275 18 In in IN cord-299949-kmn53e2z 275 19 Semliki Semliki NNP cord-299949-kmn53e2z 275 20 Forest Forest NNP cord-299949-kmn53e2z 275 21 virus virus NN cord-299949-kmn53e2z 275 22 encephalitis encephalitis RB cord-299949-kmn53e2z 275 23 , , , cord-299949-kmn53e2z 275 24 antibody antibody NN cord-299949-kmn53e2z 275 25 rapidly rapidly RB cord-299949-kmn53e2z 275 26 clears clear VBZ cord-299949-kmn53e2z 275 27 infectious infectious JJ cord-299949-kmn53e2z 275 28 virus virus NN cord-299949-kmn53e2z 275 29 and and CC cord-299949-kmn53e2z 275 30 is be VBZ cord-299949-kmn53e2z 275 31 required require VBN cord-299949-kmn53e2z 275 32 to to TO cord-299949-kmn53e2z 275 33 eliminate eliminate VB cord-299949-kmn53e2z 275 34 viral viral JJ cord-299949-kmn53e2z 275 35 material material NN cord-299949-kmn53e2z 275 36 from from IN cord-299949-kmn53e2z 275 37 the the DT cord-299949-kmn53e2z 275 38 brain brain NN cord-299949-kmn53e2z 275 39 , , , cord-299949-kmn53e2z 275 40 but but CC cord-299949-kmn53e2z 275 41 is be VBZ cord-299949-kmn53e2z 275 42 not not RB cord-299949-kmn53e2z 275 43 required require VBN cord-299949-kmn53e2z 275 44 to to TO cord-299949-kmn53e2z 275 45 generate generate VB cord-299949-kmn53e2z 275 46 lesions lesion NNS cord-299949-kmn53e2z 275 47 of of IN cord-299949-kmn53e2z 275 48 demyelination demyelination NN cord-299949-kmn53e2z 276 1 Early early JJ cord-299949-kmn53e2z 276 2 events event NNS cord-299949-kmn53e2z 276 3 in in IN cord-299949-kmn53e2z 276 4 alphavirus alphavirus NNP cord-299949-kmn53e2z 276 5 replication replication NN cord-299949-kmn53e2z 276 6 determine determine VBP cord-299949-kmn53e2z 276 7 the the DT cord-299949-kmn53e2z 276 8 outcome outcome NN cord-299949-kmn53e2z 276 9 of of IN cord-299949-kmn53e2z 276 10 infection infection NN cord-299949-kmn53e2z 276 11 T T NNP cord-299949-kmn53e2z 276 12 Helper helper NN cord-299949-kmn53e2z 276 13 cell cell NN cord-299949-kmn53e2z 276 14 - - : cord-299949-kmn53e2z 276 15 and and CC cord-299949-kmn53e2z 276 16 CD40-dependent cd40-dependent CD cord-299949-kmn53e2z 276 17 germline germline NN cord-299949-kmn53e2z 276 18 IgM igm NN cord-299949-kmn53e2z 276 19 prevents prevent VBZ cord-299949-kmn53e2z 276 20 chronic chronic JJ cord-299949-kmn53e2z 276 21 virus virus NN cord-299949-kmn53e2z 276 22 - - HYPH cord-299949-kmn53e2z 276 23 induced induce VBN cord-299949-kmn53e2z 276 24 demyelinating demyelinate VBG cord-299949-kmn53e2z 276 25 disease disease NN cord-299949-kmn53e2z 276 26 Expression expression NN cord-299949-kmn53e2z 276 27 of of IN cord-299949-kmn53e2z 276 28 a a DT cord-299949-kmn53e2z 276 29 dominant dominant JJ cord-299949-kmn53e2z 276 30 negative negative JJ cord-299949-kmn53e2z 276 31 IFN IFN NNP cord-299949-kmn53e2z 276 32 - - HYPH cord-299949-kmn53e2z 276 33 G G NNP cord-299949-kmn53e2z 276 34 receptor receptor NN cord-299949-kmn53e2z 276 35 on on IN cord-299949-kmn53e2z 276 36 mouse mouse NN cord-299949-kmn53e2z 276 37 oligodendrocytes oligodendrocyte NNS cord-299949-kmn53e2z 276 38 Role role NN cord-299949-kmn53e2z 276 39 of of IN cord-299949-kmn53e2z 276 40 interferon interferon NN cord-299949-kmn53e2z 276 41 and and CC cord-299949-kmn53e2z 276 42 interferon interferon NN cord-299949-kmn53e2z 276 43 regulatory regulatory JJ cord-299949-kmn53e2z 276 44 factors factor NNS cord-299949-kmn53e2z 276 45 in in IN cord-299949-kmn53e2z 276 46 early early JJ cord-299949-kmn53e2z 276 47 protection protection NN cord-299949-kmn53e2z 276 48 against against IN cord-299949-kmn53e2z 276 49 venezuelan venezuelan JJ cord-299949-kmn53e2z 276 50 equine equine NN cord-299949-kmn53e2z 276 51 encephalitis encephalitis NN cord-299949-kmn53e2z 276 52 virus virus NN cord-299949-kmn53e2z 276 53 infection infection NN cord-299949-kmn53e2z 277 1 The the DT cord-299949-kmn53e2z 277 2 functional functional JJ cord-299949-kmn53e2z 277 3 , , , cord-299949-kmn53e2z 277 4 social social JJ cord-299949-kmn53e2z 277 5 and and CC cord-299949-kmn53e2z 277 6 economic economic JJ cord-299949-kmn53e2z 277 7 impact impact NN cord-299949-kmn53e2z 277 8 of of IN cord-299949-kmn53e2z 277 9 acute acute JJ cord-299949-kmn53e2z 277 10 encephalitis encephalitis JJ cord-299949-kmn53e2z 277 11 syndrome syndrome NN cord-299949-kmn53e2z 277 12 in in IN cord-299949-kmn53e2z 277 13 Nepal Nepal NNP cord-299949-kmn53e2z 277 14 -a -a : cord-299949-kmn53e2z 277 15 longitudinal longitudinal JJ cord-299949-kmn53e2z 277 16 follow follow NN cord-299949-kmn53e2z 277 17 - - HYPH cord-299949-kmn53e2z 277 18 up up NN cord-299949-kmn53e2z 277 19 study study NN cord-299949-kmn53e2z 277 20 ( ( -LRB- cord-299949-kmn53e2z 277 21 Zunt Zunt NNP cord-299949-kmn53e2z 277 22 Pathogenesis Pathogenesis NNP cord-299949-kmn53e2z 277 23 of of IN cord-299949-kmn53e2z 277 24 lentivirus lentivirus NN cord-299949-kmn53e2z 277 25 infections infection NNS cord-299949-kmn53e2z 277 26 West West NNP cord-299949-kmn53e2z 277 27 Nile Nile NNP cord-299949-kmn53e2z 277 28 virus virus NN cord-299949-kmn53e2z 277 29 neuroinvasive neuroinvasive JJ cord-299949-kmn53e2z 277 30 disease disease NN cord-299949-kmn53e2z 277 31 : : : cord-299949-kmn53e2z 277 32 neurological neurological JJ cord-299949-kmn53e2z 277 33 manifestations manifestation NNS cord-299949-kmn53e2z 277 34 and and CC cord-299949-kmn53e2z 277 35 prospective prospective JJ cord-299949-kmn53e2z 277 36 longitudinal longitudinal JJ cord-299949-kmn53e2z 277 37 outcomes outcome NNS cord-299949-kmn53e2z 277 38 TNFa TNFa NNP cord-299949-kmn53e2z 277 39 acts act VBZ cord-299949-kmn53e2z 277 40 as as IN cord-299949-kmn53e2z 277 41 an an DT cord-299949-kmn53e2z 277 42 immunoregulator immunoregulator NN cord-299949-kmn53e2z 277 43 in in IN cord-299949-kmn53e2z 277 44 the the DT cord-299949-kmn53e2z 277 45 mouse mouse NN cord-299949-kmn53e2z 277 46 brain brain NN cord-299949-kmn53e2z 277 47 by by IN cord-299949-kmn53e2z 277 48 reducing reduce VBG cord-299949-kmn53e2z 277 49 the the DT cord-299949-kmn53e2z 277 50 incidence incidence NN cord-299949-kmn53e2z 277 51 of of IN cord-299949-kmn53e2z 277 52 severe severe JJ cord-299949-kmn53e2z 277 53 disease disease NN cord-299949-kmn53e2z 277 54 following follow VBG cord-299949-kmn53e2z 277 55 Japanese japanese JJ cord-299949-kmn53e2z 277 56 encephalitis encephalitis RB cord-299949-kmn53e2z 277 57 virus virus NN cord-299949-kmn53e2z 277 58 infection infection NN cord-299949-kmn53e2z 277 59 CD200-CD200R1 CD200-CD200R1 NNP cord-299949-kmn53e2z 277 60 interaction interaction NN cord-299949-kmn53e2z 277 61 contributes contribute VBZ cord-299949-kmn53e2z 277 62 to to IN cord-299949-kmn53e2z 277 63 neuroprotective neuroprotective JJ cord-299949-kmn53e2z 277 64 effects effect NNS cord-299949-kmn53e2z 277 65 of of IN cord-299949-kmn53e2z 277 66 anandamide anandamide NN cord-299949-kmn53e2z 277 67 on on IN cord-299949-kmn53e2z 277 68 experimentally experimentally RB cord-299949-kmn53e2z 277 69 induced induce VBN cord-299949-kmn53e2z 277 70 inflammation inflammation NN cord-299949-kmn53e2z 277 71 Down down IN cord-299949-kmn53e2z 277 72 - - HYPH cord-299949-kmn53e2z 277 73 regulation regulation NN cord-299949-kmn53e2z 277 74 of of IN cord-299949-kmn53e2z 277 75 the the DT cord-299949-kmn53e2z 277 76 macrophage macrophage NN cord-299949-kmn53e2z 277 77 lineage lineage NN cord-299949-kmn53e2z 277 78 through through IN cord-299949-kmn53e2z 277 79 interaction interaction NN cord-299949-kmn53e2z 277 80 with with IN cord-299949-kmn53e2z 277 81 OX2 OX2 NNP cord-299949-kmn53e2z 277 82 ( ( -LRB- cord-299949-kmn53e2z 277 83 CD200 cd200 NN cord-299949-kmn53e2z 277 84 ) ) -RRB- cord-299949-kmn53e2z 277 85 Central central JJ cord-299949-kmn53e2z 277 86 nervous nervous JJ cord-299949-kmn53e2z 277 87 system system NN cord-299949-kmn53e2z 277 88 chemokine chemokine NN cord-299949-kmn53e2z 277 89 expression expression NN cord-299949-kmn53e2z 277 90 during during IN cord-299949-kmn53e2z 277 91 Theiler Theiler NNP cord-299949-kmn53e2z 277 92 's 's POS cord-299949-kmn53e2z 277 93 virus virus NN cord-299949-kmn53e2z 277 94 - - HYPH cord-299949-kmn53e2z 277 95 induced induce VBN cord-299949-kmn53e2z 277 96 demyelinating demyelinate VBG cord-299949-kmn53e2z 277 97 disease disease NN cord-299949-kmn53e2z 278 1 The the DT cord-299949-kmn53e2z 278 2 production production NN cord-299949-kmn53e2z 278 3 of of IN cord-299949-kmn53e2z 278 4 antibody antibody NN cord-299949-kmn53e2z 278 5 by by IN cord-299949-kmn53e2z 278 6 invading invade VBG cord-299949-kmn53e2z 278 7 B b NN cord-299949-kmn53e2z 278 8 cells cell NNS cord-299949-kmn53e2z 278 9 is be VBZ cord-299949-kmn53e2z 278 10 required require VBN cord-299949-kmn53e2z 278 11 for for IN cord-299949-kmn53e2z 278 12 the the DT cord-299949-kmn53e2z 278 13 clearance clearance NN cord-299949-kmn53e2z 278 14 of of IN cord-299949-kmn53e2z 278 15 rabies rabies NN cord-299949-kmn53e2z 278 16 virus virus NN cord-299949-kmn53e2z 278 17 from from IN cord-299949-kmn53e2z 278 18 the the DT cord-299949-kmn53e2z 278 19 central central JJ cord-299949-kmn53e2z 278 20 nervous nervous JJ cord-299949-kmn53e2z 278 21 system system NN cord-299949-kmn53e2z 278 22 Interleukin-6 Interleukin-6 NNP cord-299949-kmn53e2z 278 23 ( ( -LRB- cord-299949-kmn53e2z 278 24 IL-6 IL-6 NNP cord-299949-kmn53e2z 278 25 ) ) -RRB- cord-299949-kmn53e2z 278 26 and and CC cord-299949-kmn53e2z 278 27 IL-17 IL-17 NNP cord-299949-kmn53e2z 278 28 synergistically synergistically RB cord-299949-kmn53e2z 278 29 promote promote VB cord-299949-kmn53e2z 278 30 viral viral JJ cord-299949-kmn53e2z 278 31 persistence persistence NN cord-299949-kmn53e2z 278 32 by by IN cord-299949-kmn53e2z 278 33 inhibiting inhibit VBG cord-299949-kmn53e2z 278 34 cellular cellular JJ cord-299949-kmn53e2z 278 35 apoptosis apoptosis NN cord-299949-kmn53e2z 278 36 and and CC cord-299949-kmn53e2z 278 37 cytotoxic cytotoxic JJ cord-299949-kmn53e2z 278 38 T T NNP cord-299949-kmn53e2z 278 39 cell cell NN cord-299949-kmn53e2z 278 40 function function NN cord-299949-kmn53e2z 278 41 Th17 Th17 . cord-299949-kmn53e2z 279 1 cells cell NNS cord-299949-kmn53e2z 279 2 enhance enhance VBP cord-299949-kmn53e2z 279 3 viral viral JJ cord-299949-kmn53e2z 279 4 persistence persistence NN cord-299949-kmn53e2z 279 5 and and CC cord-299949-kmn53e2z 279 6 inhibit inhibit VB cord-299949-kmn53e2z 279 7 T t NN cord-299949-kmn53e2z 279 8 cell cell NN cord-299949-kmn53e2z 279 9 cytotoxicity cytotoxicity NN cord-299949-kmn53e2z 279 10 in in IN cord-299949-kmn53e2z 279 11 a a DT cord-299949-kmn53e2z 279 12 model model NN cord-299949-kmn53e2z 279 13 of of IN cord-299949-kmn53e2z 279 14 chronic chronic JJ cord-299949-kmn53e2z 279 15 virus virus NN cord-299949-kmn53e2z 279 16 infection infection NN cord-299949-kmn53e2z 279 17 Regulation regulation NN cord-299949-kmn53e2z 279 18 of of IN cord-299949-kmn53e2z 279 19 lymphocyte lymphocyte NN cord-299949-kmn53e2z 279 20 homing homing NN cord-299949-kmn53e2z 279 21 into into IN cord-299949-kmn53e2z 279 22 the the DT cord-299949-kmn53e2z 279 23 brain brain NN cord-299949-kmn53e2z 279 24 during during IN cord-299949-kmn53e2z 279 25 viral viral JJ cord-299949-kmn53e2z 279 26 encephalitis encephalitis RB cord-299949-kmn53e2z 279 27 at at IN cord-299949-kmn53e2z 279 28 various various JJ cord-299949-kmn53e2z 279 29 stages stage NNS cord-299949-kmn53e2z 279 30 of of IN cord-299949-kmn53e2z 279 31 infection infection NN cord-299949-kmn53e2z 279 32 Expression expression NN cord-299949-kmn53e2z 279 33 of of IN cord-299949-kmn53e2z 279 34 toll toll NN cord-299949-kmn53e2z 279 35 - - HYPH cord-299949-kmn53e2z 279 36 like like JJ cord-299949-kmn53e2z 279 37 receptor receptor NN cord-299949-kmn53e2z 279 38 3 3 CD cord-299949-kmn53e2z 279 39 in in IN cord-299949-kmn53e2z 279 40 the the DT cord-299949-kmn53e2z 279 41 human human JJ cord-299949-kmn53e2z 279 42 cerebellar cerebellar JJ cord-299949-kmn53e2z 279 43 cortex cortex NN cord-299949-kmn53e2z 279 44 in in IN cord-299949-kmn53e2z 279 45 rabies rabie NNS cord-299949-kmn53e2z 279 46 , , , cord-299949-kmn53e2z 279 47 herpes herpes NN cord-299949-kmn53e2z 279 48 simplex simplex NN cord-299949-kmn53e2z 279 49 encephalitis encephalitis RB cord-299949-kmn53e2z 279 50 , , , cord-299949-kmn53e2z 279 51 and and CC cord-299949-kmn53e2z 279 52 other other JJ cord-299949-kmn53e2z 279 53 neurological neurological JJ cord-299949-kmn53e2z 279 54 diseases disease NNS cord-299949-kmn53e2z 280 1 Type type NN cord-299949-kmn53e2z 281 1 I -PRON- PRP cord-299949-kmn53e2z 282 1 interferon interferon NN cord-299949-kmn53e2z 282 2 signals signal VBZ cord-299949-kmn53e2z 282 3 control control VBP cord-299949-kmn53e2z 282 4 Theiler Theiler NNP cord-299949-kmn53e2z 282 5 's 's POS cord-299949-kmn53e2z 282 6 virus virus NN cord-299949-kmn53e2z 282 7 infection infection NN cord-299949-kmn53e2z 282 8 site site NN cord-299949-kmn53e2z 282 9 , , , cord-299949-kmn53e2z 282 10 cellular cellular JJ cord-299949-kmn53e2z 282 11 Infiltration Infiltration NNP cord-299949-kmn53e2z 282 12 and and CC cord-299949-kmn53e2z 282 13 T T NNP cord-299949-kmn53e2z 282 14 cell cell NN cord-299949-kmn53e2z 282 15 stimulation stimulation NN cord-299949-kmn53e2z 282 16 in in IN cord-299949-kmn53e2z 282 17 the the DT cord-299949-kmn53e2z 282 18 CNS CNS NNP cord-299949-kmn53e2z 282 19 Evidence evidence NN cord-299949-kmn53e2z 282 20 for for IN cord-299949-kmn53e2z 282 21 transforming transform VBG cord-299949-kmn53e2z 282 22 growth growth NN cord-299949-kmn53e2z 282 23 factorbeta factorbeta NN cord-299949-kmn53e2z 282 24 expression expression NN cord-299949-kmn53e2z 282 25 in in IN cord-299949-kmn53e2z 282 26 human human JJ cord-299949-kmn53e2z 282 27 leptomeningeal leptomeningeal NN cord-299949-kmn53e2z 282 28 cells cell NNS cord-299949-kmn53e2z 282 29 and and CC cord-299949-kmn53e2z 282 30 transforming transform VBG cord-299949-kmn53e2z 282 31 growth growth NN cord-299949-kmn53e2z 282 32 factorbeta factorbeta NN cord-299949-kmn53e2z 282 33 - - HYPH cord-299949-kmn53e2z 282 34 like like JJ cord-299949-kmn53e2z 282 35 activity activity NN cord-299949-kmn53e2z 282 36 in in IN cord-299949-kmn53e2z 282 37 human human JJ cord-299949-kmn53e2z 282 38 cerebrospinal cerebrospinal NN cord-299949-kmn53e2z 282 39 fluid fluid NN cord-299949-kmn53e2z 282 40 NLRP3 NLRP3 NNP cord-299949-kmn53e2z 282 41 inflammasome inflammasome NN cord-299949-kmn53e2z 282 42 : : : cord-299949-kmn53e2z 282 43 key key JJ cord-299949-kmn53e2z 282 44 mediator mediator NN cord-299949-kmn53e2z 282 45 of of IN cord-299949-kmn53e2z 282 46 neuroinflammation neuroinflammation NN cord-299949-kmn53e2z 282 47 in in IN cord-299949-kmn53e2z 282 48 murine murine JJ cord-299949-kmn53e2z 282 49 japanese japanese JJ cord-299949-kmn53e2z 282 50 encephalitis encephalitis RB cord-299949-kmn53e2z 282 51 Pattern Pattern NNP cord-299949-kmn53e2z 282 52 recognition recognition NN cord-299949-kmn53e2z 282 53 receptors receptor NNS cord-299949-kmn53e2z 282 54 and and CC cord-299949-kmn53e2z 282 55 central central JJ cord-299949-kmn53e2z 282 56 nervous nervous JJ cord-299949-kmn53e2z 282 57 system system NN cord-299949-kmn53e2z 283 1 repair repair VB cord-299949-kmn53e2z 284 1 Monocyte Monocyte NNP cord-299949-kmn53e2z 284 2 / / SYM cord-299949-kmn53e2z 284 3 Macrophage macrophage NN cord-299949-kmn53e2z 284 4 traffic traffic NN cord-299949-kmn53e2z 284 5 in in IN cord-299949-kmn53e2z 284 6 HIV HIV NNP cord-299949-kmn53e2z 284 7 and and CC cord-299949-kmn53e2z 284 8 SIV SIV NNP cord-299949-kmn53e2z 284 9 encephalitis encephalitis RB cord-299949-kmn53e2z 285 1 The the DT cord-299949-kmn53e2z 285 2 role role NN cord-299949-kmn53e2z 285 3 of of IN cord-299949-kmn53e2z 285 4 CD8 CD8 NNP cord-299949-kmn53e2z 285 5 þ þ NNP cord-299949-kmn53e2z 285 6 T T NNP cord-299949-kmn53e2z 285 7 cells cell NNS cord-299949-kmn53e2z 285 8 and and CC cord-299949-kmn53e2z 285 9 major major JJ cord-299949-kmn53e2z 285 10 histocompatibility histocompatibility NN cord-299949-kmn53e2z 285 11 complex complex NN cord-299949-kmn53e2z 285 12 class class NN cord-299949-kmn53e2z 286 1 I -PRON- PRP cord-299949-kmn53e2z 286 2 expression expression VBP cord-299949-kmn53e2z 286 3 in in IN cord-299949-kmn53e2z 286 4 the the DT cord-299949-kmn53e2z 286 5 central central JJ cord-299949-kmn53e2z 286 6 nervous nervous JJ cord-299949-kmn53e2z 286 7 system system NN cord-299949-kmn53e2z 286 8 of of IN cord-299949-kmn53e2z 286 9 mice mouse NNS cord-299949-kmn53e2z 286 10 infected infect VBN cord-299949-kmn53e2z 286 11 with with IN cord-299949-kmn53e2z 286 12 neurovirulent neurovirulent NNP cord-299949-kmn53e2z 286 13 sindbis sindbis NNP cord-299949-kmn53e2z 286 14 virus virus NN cord-299949-kmn53e2z 287 1 Neuronal neuronal JJ cord-299949-kmn53e2z 287 2 CXCL10 CXCL10 NNP cord-299949-kmn53e2z 287 3 directs direct VBZ cord-299949-kmn53e2z 287 4 CD8 CD8 NNP cord-299949-kmn53e2z 287 5 þ þ NNP cord-299949-kmn53e2z 287 6 T T NNP cord-299949-kmn53e2z 287 7 - - HYPH cord-299949-kmn53e2z 287 8 cell cell NN cord-299949-kmn53e2z 287 9 recruitment recruitment NN cord-299949-kmn53e2z 287 10 and and CC cord-299949-kmn53e2z 287 11 control control NN cord-299949-kmn53e2z 287 12 of of IN cord-299949-kmn53e2z 287 13 West West NNP cord-299949-kmn53e2z 287 14 Nile Nile NNP cord-299949-kmn53e2z 287 15 virus virus NN cord-299949-kmn53e2z 287 16 encephalitis encephalitis RB cord-299949-kmn53e2z 287 17 Virus virus NN cord-299949-kmn53e2z 287 18 infections infection NNS cord-299949-kmn53e2z 287 19 in in IN cord-299949-kmn53e2z 287 20 the the DT cord-299949-kmn53e2z 287 21 nervous nervous JJ cord-299949-kmn53e2z 287 22 system system NN cord-299949-kmn53e2z 287 23 Role role NN cord-299949-kmn53e2z 287 24 of of IN cord-299949-kmn53e2z 287 25 chemokines chemokine NNS cord-299949-kmn53e2z 287 26 in in IN cord-299949-kmn53e2z 287 27 the the DT cord-299949-kmn53e2z 287 28 enhancement enhancement NN cord-299949-kmn53e2z 287 29 of of IN cord-299949-kmn53e2z 287 30 BBB BBB NNP cord-299949-kmn53e2z 287 31 permeability permeability NN cord-299949-kmn53e2z 287 32 and and CC cord-299949-kmn53e2z 287 33 inflammatory inflammatory JJ cord-299949-kmn53e2z 287 34 infiltration infiltration NN cord-299949-kmn53e2z 287 35 after after IN cord-299949-kmn53e2z 287 36 rabies rabies NN cord-299949-kmn53e2z 287 37 virus virus NN cord-299949-kmn53e2z 287 38 infection infection NN cord-299949-kmn53e2z 287 39 Interleukin Interleukin NNP cord-299949-kmn53e2z 287 40 10 10 CD cord-299949-kmn53e2z 287 41 modulation modulation NN cord-299949-kmn53e2z 287 42 of of IN cord-299949-kmn53e2z 287 43 pathogenic pathogenic JJ cord-299949-kmn53e2z 287 44 Th17 Th17 NNP cord-299949-kmn53e2z 287 45 cells cell NNS cord-299949-kmn53e2z 287 46 during during IN cord-299949-kmn53e2z 287 47 fatal fatal JJ cord-299949-kmn53e2z 287 48 alphavirus alphavirus NN cord-299949-kmn53e2z 287 49 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 287 50 Inflammasome Inflammasome NNP cord-299949-kmn53e2z 287 51 adaptor adaptor NN cord-299949-kmn53e2z 287 52 protein protein NN cord-299949-kmn53e2z 287 53 apoptosis apoptosis NN cord-299949-kmn53e2z 287 54 - - HYPH cord-299949-kmn53e2z 287 55 associated associate VBN cord-299949-kmn53e2z 287 56 speck speck NN cord-299949-kmn53e2z 287 57 - - HYPH cord-299949-kmn53e2z 287 58 like like JJ cord-299949-kmn53e2z 287 59 protein protein NN cord-299949-kmn53e2z 287 60 containing contain VBG cord-299949-kmn53e2z 287 61 CARD card NN cord-299949-kmn53e2z 287 62 ( ( -LRB- cord-299949-kmn53e2z 287 63 ASC ASC NNP cord-299949-kmn53e2z 287 64 ) ) -RRB- cord-299949-kmn53e2z 287 65 is be VBZ cord-299949-kmn53e2z 287 66 critical critical JJ cord-299949-kmn53e2z 287 67 for for IN cord-299949-kmn53e2z 287 68 the the DT cord-299949-kmn53e2z 287 69 immune immune JJ cord-299949-kmn53e2z 287 70 response response NN cord-299949-kmn53e2z 287 71 and and CC cord-299949-kmn53e2z 287 72 survival survival NN cord-299949-kmn53e2z 287 73 in in IN cord-299949-kmn53e2z 287 74 West West NNP cord-299949-kmn53e2z 287 75 Nile Nile NNP cord-299949-kmn53e2z 287 76 virus virus NN cord-299949-kmn53e2z 287 77 encephalitis encephalitis RB cord-299949-kmn53e2z 287 78 Detrimental detrimental JJ cord-299949-kmn53e2z 287 79 contribution contribution NN cord-299949-kmn53e2z 287 80 of of IN cord-299949-kmn53e2z 287 81 the the DT cord-299949-kmn53e2z 287 82 immuno immuno JJ cord-299949-kmn53e2z 287 83 - - JJ cord-299949-kmn53e2z 287 84 inhibitor inhibitor NN cord-299949-kmn53e2z 287 85 B7-H1 B7-H1 NNP cord-299949-kmn53e2z 287 86 to to IN cord-299949-kmn53e2z 287 87 rabies rabies NN cord-299949-kmn53e2z 287 88 virus virus NN cord-299949-kmn53e2z 287 89 encephalitis encephalitis NN cord-299949-kmn53e2z 287 90 Modulation modulation NN cord-299949-kmn53e2z 287 91 of of IN cord-299949-kmn53e2z 287 92 HLA HLA NNP cord-299949-kmn53e2z 287 93 - - HYPH cord-299949-kmn53e2z 287 94 g g NN cord-299949-kmn53e2z 287 95 expression expression NN cord-299949-kmn53e2z 287 96 in in IN cord-299949-kmn53e2z 287 97 human human JJ cord-299949-kmn53e2z 287 98 neural neural JJ cord-299949-kmn53e2z 287 99 cells cell NNS cord-299949-kmn53e2z 287 100 after after IN cord-299949-kmn53e2z 287 101 neurotropic neurotropic NNP cord-299949-kmn53e2z 287 102 viral viral JJ cord-299949-kmn53e2z 287 103 infections infection NNS cord-299949-kmn53e2z 287 104 Dynamic dynamic JJ cord-299949-kmn53e2z 287 105 regulation regulation NN cord-299949-kmn53e2z 287 106 of of IN cord-299949-kmn53e2z 287 107 a a DT cord-299949-kmn53e2z 287 108 - - : cord-299949-kmn53e2z 287 109 and and CC cord-299949-kmn53e2z 287 110 b b NN cord-299949-kmn53e2z 287 111 - - HYPH cord-299949-kmn53e2z 287 112 chemokine chemokine NN cord-299949-kmn53e2z 287 113 expression expression NN cord-299949-kmn53e2z 287 114 in in IN cord-299949-kmn53e2z 287 115 the the DT cord-299949-kmn53e2z 287 116 central central JJ cord-299949-kmn53e2z 287 117 nervous nervous JJ cord-299949-kmn53e2z 287 118 system system NN cord-299949-kmn53e2z 287 119 during during IN cord-299949-kmn53e2z 287 120 mouse mouse NNP cord-299949-kmn53e2z 287 121 hepatitis hepatitis NNP cord-299949-kmn53e2z 287 122 virus virus NN cord-299949-kmn53e2z 287 123 - - HYPH cord-299949-kmn53e2z 287 124 induced induce VBN cord-299949-kmn53e2z 287 125 demyelinating demyelinate VBG cord-299949-kmn53e2z 287 126 disease disease NN cord-299949-kmn53e2z 287 127 Mice mouse NNS cord-299949-kmn53e2z 287 128 deficient deficient JJ cord-299949-kmn53e2z 287 129 in in IN cord-299949-kmn53e2z 287 130 interferon interferon NN cord-299949-kmn53e2z 287 131 - - HYPH cord-299949-kmn53e2z 287 132 gamma gamma NN cord-299949-kmn53e2z 287 133 or or CC cord-299949-kmn53e2z 287 134 interferon interferon NN cord-299949-kmn53e2z 287 135 - - HYPH cord-299949-kmn53e2z 287 136 gamma gamma NN cord-299949-kmn53e2z 287 137 receptor receptor NN cord-299949-kmn53e2z 287 138 1 1 CD cord-299949-kmn53e2z 287 139 have have VBP cord-299949-kmn53e2z 287 140 distinct distinct JJ cord-299949-kmn53e2z 287 141 inflammatory inflammatory JJ cord-299949-kmn53e2z 287 142 responses response NNS cord-299949-kmn53e2z 287 143 to to IN cord-299949-kmn53e2z 287 144 acute acute JJ cord-299949-kmn53e2z 287 145 viral viral JJ cord-299949-kmn53e2z 287 146 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 287 147 Persistence persistence NN cord-299949-kmn53e2z 287 148 of of IN cord-299949-kmn53e2z 287 149 viral viral JJ cord-299949-kmn53e2z 287 150 RNA RNA NNP cord-299949-kmn53e2z 287 151 in in IN cord-299949-kmn53e2z 287 152 mouse mouse NN cord-299949-kmn53e2z 287 153 brains brain NNS cord-299949-kmn53e2z 287 154 after after IN cord-299949-kmn53e2z 287 155 recovery recovery NN cord-299949-kmn53e2z 287 156 from from IN cord-299949-kmn53e2z 287 157 acute acute JJ cord-299949-kmn53e2z 287 158 alphavirus alphavirus NNP cord-299949-kmn53e2z 287 159 encephalitis encephalitis NNP cord-299949-kmn53e2z 287 160 Antibody antibody NN cord-299949-kmn53e2z 287 161 - - HYPH cord-299949-kmn53e2z 287 162 mediated mediate VBN cord-299949-kmn53e2z 287 163 clearance clearance NN cord-299949-kmn53e2z 287 164 of of IN cord-299949-kmn53e2z 287 165 alphavirus alphavirus NNP cord-299949-kmn53e2z 287 166 infection infection NN cord-299949-kmn53e2z 287 167 from from IN cord-299949-kmn53e2z 287 168 neurons neuron NNS cord-299949-kmn53e2z 287 169 Resistance resistance NN cord-299949-kmn53e2z 287 170 of of IN cord-299949-kmn53e2z 287 171 interleukin-1beta interleukin-1beta RB cord-299949-kmn53e2z 287 172 - - HYPH cord-299949-kmn53e2z 287 173 deficient deficient JJ cord-299949-kmn53e2z 287 174 mice mouse NNS cord-299949-kmn53e2z 287 175 to to IN cord-299949-kmn53e2z 287 176 fatal fatal JJ cord-299949-kmn53e2z 287 177 sindbis sindbis NN cord-299949-kmn53e2z 287 178 virus virus NN cord-299949-kmn53e2z 287 179 encephalitis encephalitis NNP cord-299949-kmn53e2z 287 180 Antibody Antibody NNP cord-299949-kmn53e2z 287 181 prevents prevent VBZ cord-299949-kmn53e2z 287 182 virus virus NN cord-299949-kmn53e2z 287 183 reactivation reactivation NN cord-299949-kmn53e2z 287 184 within within IN cord-299949-kmn53e2z 287 185 the the DT cord-299949-kmn53e2z 287 186 central central JJ cord-299949-kmn53e2z 287 187 nervous nervous JJ cord-299949-kmn53e2z 287 188 system system NN cord-299949-kmn53e2z 287 189 Mouse Mouse NNP cord-299949-kmn53e2z 287 190 hepatitis hepatitis NN cord-299949-kmn53e2z 287 191 virus virus NN cord-299949-kmn53e2z 287 192 is be VBZ cord-299949-kmn53e2z 287 193 cleared clear VBN cord-299949-kmn53e2z 287 194 from from IN cord-299949-kmn53e2z 287 195 the the DT cord-299949-kmn53e2z 287 196 central central JJ cord-299949-kmn53e2z 287 197 nervous nervous JJ cord-299949-kmn53e2z 287 198 systems system NNS cord-299949-kmn53e2z 287 199 of of IN cord-299949-kmn53e2z 287 200 mice mouse NNS cord-299949-kmn53e2z 287 201 lacking lack VBG cord-299949-kmn53e2z 287 202 perforin perforin NNP cord-299949-kmn53e2z 287 203 - - HYPH cord-299949-kmn53e2z 287 204 mediated mediate VBN cord-299949-kmn53e2z 287 205 cytolysis cytolysis NN cord-299949-kmn53e2z 287 206 Characterization characterization NN cord-299949-kmn53e2z 287 207 of of IN cord-299949-kmn53e2z 287 208 the the DT cord-299949-kmn53e2z 287 209 inflammatory inflammatory JJ cord-299949-kmn53e2z 287 210 response response NN cord-299949-kmn53e2z 287 211 in in IN cord-299949-kmn53e2z 287 212 the the DT cord-299949-kmn53e2z 287 213 central central JJ cord-299949-kmn53e2z 287 214 nervous nervous JJ cord-299949-kmn53e2z 287 215 system system NN cord-299949-kmn53e2z 287 216 of of IN cord-299949-kmn53e2z 287 217 mice mouse NNS cord-299949-kmn53e2z 287 218 susceptible susceptible JJ cord-299949-kmn53e2z 287 219 or or CC cord-299949-kmn53e2z 287 220 resistant resistant JJ cord-299949-kmn53e2z 287 221 to to IN cord-299949-kmn53e2z 287 222 demyelination demyelination NN cord-299949-kmn53e2z 287 223 by by IN cord-299949-kmn53e2z 287 224 Theiler Theiler NNP cord-299949-kmn53e2z 287 225 's 's POS cord-299949-kmn53e2z 287 226 virus virus NN cord-299949-kmn53e2z 287 227 Infection infection NN cord-299949-kmn53e2z 287 228 of of IN cord-299949-kmn53e2z 287 229 mouse mouse NN cord-299949-kmn53e2z 287 230 neurones neurone NNS cord-299949-kmn53e2z 287 231 by by IN cord-299949-kmn53e2z 287 232 West West NNP cord-299949-kmn53e2z 287 233 Nile Nile NNP cord-299949-kmn53e2z 287 234 virus virus NN cord-299949-kmn53e2z 287 235 is be VBZ cord-299949-kmn53e2z 287 236 modulated modulate VBN cord-299949-kmn53e2z 287 237 by by IN cord-299949-kmn53e2z 287 238 the the DT cord-299949-kmn53e2z 287 239 interferon interferon NN cord-299949-kmn53e2z 287 240 - - HYPH cord-299949-kmn53e2z 287 241 inducible inducible JJ cord-299949-kmn53e2z 287 242 2 2 CD cord-299949-kmn53e2z 287 243 0 0 CD cord-299949-kmn53e2z 287 244 -5 -5 CD cord-299949-kmn53e2z 287 245 0 0 CD cord-299949-kmn53e2z 287 246 oligoadenylate oligoadenylate NNP cord-299949-kmn53e2z 287 247 synthetase synthetase NNP cord-299949-kmn53e2z 287 248 1b 1b NNP cord-299949-kmn53e2z 287 249 protein protein NNP cord-299949-kmn53e2z 287 250 CXCR3-Dependent cxcr3-dependent NN cord-299949-kmn53e2z 287 251 plasma plasma NN cord-299949-kmn53e2z 287 252 blast blast NN cord-299949-kmn53e2z 287 253 migration migration NN cord-299949-kmn53e2z 287 254 to to IN cord-299949-kmn53e2z 287 255 the the DT cord-299949-kmn53e2z 287 256 central central JJ cord-299949-kmn53e2z 287 257 nervous nervous JJ cord-299949-kmn53e2z 287 258 system system NN cord-299949-kmn53e2z 287 259 during during IN cord-299949-kmn53e2z 287 260 viral viral JJ cord-299949-kmn53e2z 287 261 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 287 262 CXCR4 cxcr4 NN cord-299949-kmn53e2z 287 263 antagonism antagonism NN cord-299949-kmn53e2z 288 1 increases increase VBZ cord-299949-kmn53e2z 288 2 T T NNP cord-299949-kmn53e2z 288 3 cell cell NN cord-299949-kmn53e2z 288 4 trafficking trafficking NN cord-299949-kmn53e2z 288 5 in in IN cord-299949-kmn53e2z 288 6 the the DT cord-299949-kmn53e2z 288 7 central central JJ cord-299949-kmn53e2z 288 8 nervous nervous JJ cord-299949-kmn53e2z 288 9 system system NN cord-299949-kmn53e2z 288 10 and and CC cord-299949-kmn53e2z 288 11 improves improve VBZ cord-299949-kmn53e2z 288 12 survival survival NN cord-299949-kmn53e2z 288 13 from from IN cord-299949-kmn53e2z 288 14 West West NNP cord-299949-kmn53e2z 288 15 Nile Nile NNP cord-299949-kmn53e2z 288 16 virus virus NN cord-299949-kmn53e2z 288 17 encephalitis encephalitis RB cord-299949-kmn53e2z 288 18 Illuminating illuminate VBG cord-299949-kmn53e2z 288 19 viral viral JJ cord-299949-kmn53e2z 288 20 infections infection NNS cord-299949-kmn53e2z 288 21 in in IN cord-299949-kmn53e2z 288 22 the the DT cord-299949-kmn53e2z 288 23 nervous nervous JJ cord-299949-kmn53e2z 288 24 system system NN cord-299949-kmn53e2z 288 25 Immune immune NN cord-299949-kmn53e2z 288 26 and and CC cord-299949-kmn53e2z 288 27 non non JJ cord-299949-kmn53e2z 288 28 - - JJ cord-299949-kmn53e2z 288 29 immune immune JJ cord-299949-kmn53e2z 288 30 actions action NNS cord-299949-kmn53e2z 288 31 of of IN cord-299949-kmn53e2z 288 32 interferon interferon NN cord-299949-kmn53e2z 288 33 - - HYPH cord-299949-kmn53e2z 288 34 b-1b b-1b NNS cord-299949-kmn53e2z 288 35 on on IN cord-299949-kmn53e2z 288 36 primary primary JJ cord-299949-kmn53e2z 288 37 human human JJ cord-299949-kmn53e2z 288 38 neural neural JJ cord-299949-kmn53e2z 288 39 cells cell NNS cord-299949-kmn53e2z 288 40 Alphavirus Alphavirus NNP cord-299949-kmn53e2z 288 41 - - HYPH cord-299949-kmn53e2z 288 42 induced induce VBN cord-299949-kmn53e2z 288 43 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 288 44 : : : cord-299949-kmn53e2z 288 45 antibodysecreting antibodysecreting NN cord-299949-kmn53e2z 288 46 cells cell NNS cord-299949-kmn53e2z 288 47 and and CC cord-299949-kmn53e2z 288 48 viral viral JJ cord-299949-kmn53e2z 288 49 clearance clearance NN cord-299949-kmn53e2z 288 50 from from IN cord-299949-kmn53e2z 288 51 the the DT cord-299949-kmn53e2z 288 52 nervous nervous JJ cord-299949-kmn53e2z 288 53 system system NN cord-299949-kmn53e2z 288 54 Recruitment recruitment NN cord-299949-kmn53e2z 288 55 and and CC cord-299949-kmn53e2z 288 56 retention retention NN cord-299949-kmn53e2z 288 57 of of IN cord-299949-kmn53e2z 288 58 B b NN cord-299949-kmn53e2z 288 59 cells cell NNS cord-299949-kmn53e2z 288 60 in in IN cord-299949-kmn53e2z 288 61 the the DT cord-299949-kmn53e2z 288 62 central central JJ cord-299949-kmn53e2z 288 63 nervous nervous JJ cord-299949-kmn53e2z 288 64 system system NN cord-299949-kmn53e2z 288 65 in in IN cord-299949-kmn53e2z 288 66 response response NN cord-299949-kmn53e2z 288 67 to to IN cord-299949-kmn53e2z 288 68 alphavirus alphavirus NNP cord-299949-kmn53e2z 288 69 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 288 70 Mode mode NN cord-299949-kmn53e2z 288 71 of of IN cord-299949-kmn53e2z 288 72 entry entry NN cord-299949-kmn53e2z 288 73 of of IN cord-299949-kmn53e2z 288 74 a a DT cord-299949-kmn53e2z 288 75 neurotropic neurotropic NNP cord-299949-kmn53e2z 288 76 arbovirus arbovirus NN cord-299949-kmn53e2z 288 77 into into IN cord-299949-kmn53e2z 288 78 the the DT cord-299949-kmn53e2z 288 79 central central JJ cord-299949-kmn53e2z 288 80 nervous nervous JJ cord-299949-kmn53e2z 288 81 system system NN cord-299949-kmn53e2z 288 82 . . . cord-299949-kmn53e2z 289 1 Reinvestigation reinvestigation NN cord-299949-kmn53e2z 289 2 of of IN cord-299949-kmn53e2z 289 3 an an DT cord-299949-kmn53e2z 289 4 old old JJ cord-299949-kmn53e2z 289 5 controversy controversy NN cord-299949-kmn53e2z 290 1 Immunologic immunologic JJ cord-299949-kmn53e2z 290 2 privilege privilege NN cord-299949-kmn53e2z 290 3 in in IN cord-299949-kmn53e2z 290 4 the the DT cord-299949-kmn53e2z 290 5 central central JJ cord-299949-kmn53e2z 290 6 nervous nervous JJ cord-299949-kmn53e2z 290 7 system system NN cord-299949-kmn53e2z 290 8 and and CC cord-299949-kmn53e2z 290 9 the the DT cord-299949-kmn53e2z 290 10 bloodbrain bloodbrain NN cord-299949-kmn53e2z 290 11 barrier barrier NN cord-299949-kmn53e2z 290 12 Rapid Rapid NNP cord-299949-kmn53e2z 290 13 nipah nipah JJ cord-299949-kmn53e2z 290 14 virus virus NN cord-299949-kmn53e2z 290 15 entry entry NN cord-299949-kmn53e2z 290 16 into into IN cord-299949-kmn53e2z 290 17 the the DT cord-299949-kmn53e2z 290 18 central central JJ cord-299949-kmn53e2z 290 19 nervous nervous JJ cord-299949-kmn53e2z 290 20 system system NN cord-299949-kmn53e2z 290 21 of of IN cord-299949-kmn53e2z 290 22 hamsters hamster NNS cord-299949-kmn53e2z 290 23 via via IN cord-299949-kmn53e2z 290 24 the the DT cord-299949-kmn53e2z 290 25 olfactory olfactory JJ cord-299949-kmn53e2z 290 26 route route NN cord-299949-kmn53e2z 290 27 Functional functional JJ cord-299949-kmn53e2z 290 28 role role NN cord-299949-kmn53e2z 290 29 of of IN cord-299949-kmn53e2z 290 30 type type NN cord-299949-kmn53e2z 290 31 I -PRON- PRP cord-299949-kmn53e2z 290 32 and and CC cord-299949-kmn53e2z 290 33 type type NN cord-299949-kmn53e2z 290 34 II II NNP cord-299949-kmn53e2z 290 35 interferons interferon NNS cord-299949-kmn53e2z 290 36 in in IN cord-299949-kmn53e2z 290 37 antiviral antiviral JJ cord-299949-kmn53e2z 290 38 defense defense NN cord-299949-kmn53e2z 290 39 Interferons interferon NNS cord-299949-kmn53e2z 290 40 , , , cord-299949-kmn53e2z 290 41 signal signal NN cord-299949-kmn53e2z 290 42 transduction transduction NN cord-299949-kmn53e2z 290 43 pathways pathway NNS cord-299949-kmn53e2z 290 44 , , , cord-299949-kmn53e2z 290 45 and and CC cord-299949-kmn53e2z 290 46 the the DT cord-299949-kmn53e2z 290 47 central central JJ cord-299949-kmn53e2z 290 48 nervous nervous JJ cord-299949-kmn53e2z 290 49 system system NN cord-299949-kmn53e2z 291 1 Flaviviruses flavivirus NNS cord-299949-kmn53e2z 291 2 are be VBP cord-299949-kmn53e2z 291 3 neurotropic neurotropic NNS cord-299949-kmn53e2z 291 4 , , , cord-299949-kmn53e2z 291 5 but but CC cord-299949-kmn53e2z 291 6 how how WRB cord-299949-kmn53e2z 291 7 do do VBP cord-299949-kmn53e2z 291 8 they -PRON- PRP cord-299949-kmn53e2z 291 9 invade invade VB cord-299949-kmn53e2z 291 10 the the DT cord-299949-kmn53e2z 291 11 CNS CNS NNP cord-299949-kmn53e2z 291 12 ? ? . cord-299949-kmn53e2z 292 1 The the DT cord-299949-kmn53e2z 292 2 epidemiology epidemiology NN cord-299949-kmn53e2z 292 3 , , , cord-299949-kmn53e2z 292 4 clinical clinical JJ cord-299949-kmn53e2z 292 5 features feature NNS cord-299949-kmn53e2z 292 6 , , , cord-299949-kmn53e2z 292 7 and and CC cord-299949-kmn53e2z 292 8 long long JJ cord-299949-kmn53e2z 292 9 - - HYPH cord-299949-kmn53e2z 292 10 term term NN cord-299949-kmn53e2z 292 11 prognosis prognosis NN cord-299949-kmn53e2z 292 12 of of IN cord-299949-kmn53e2z 292 13 japanese japanese JJ cord-299949-kmn53e2z 292 14 encephalitis encephalitis RB cord-299949-kmn53e2z 292 15 in in IN cord-299949-kmn53e2z 292 16 central central JJ cord-299949-kmn53e2z 292 17 sarawak sarawak NNP cord-299949-kmn53e2z 292 18 STAT1-independent STAT1-independent NNP cord-299949-kmn53e2z 292 19 control control NN cord-299949-kmn53e2z 292 20 of of IN cord-299949-kmn53e2z 292 21 a a DT cord-299949-kmn53e2z 292 22 neurotropic neurotropic NNP cord-299949-kmn53e2z 292 23 measles measle NNS cord-299949-kmn53e2z 292 24 virus virus NN cord-299949-kmn53e2z 292 25 Challenge Challenge NNP cord-299949-kmn53e2z 292 26 in in IN cord-299949-kmn53e2z 292 27 primary primary JJ cord-299949-kmn53e2z 292 28 neurons neuron NNS cord-299949-kmn53e2z 292 29 and and CC cord-299949-kmn53e2z 292 30 infected infected JJ cord-299949-kmn53e2z 292 31 mice mouse NNS cord-299949-kmn53e2z 292 32 Identification identification NN cord-299949-kmn53e2z 292 33 of of IN cord-299949-kmn53e2z 292 34 immunoglobulin immunoglobulin NN cord-299949-kmn53e2z 292 35 - - HYPH cord-299949-kmn53e2z 292 36 containing contain VBG cord-299949-kmn53e2z 292 37 cells cell NNS cord-299949-kmn53e2z 292 38 in in IN cord-299949-kmn53e2z 292 39 the the DT cord-299949-kmn53e2z 292 40 central central JJ cord-299949-kmn53e2z 292 41 nervous nervous JJ cord-299949-kmn53e2z 292 42 system system NN cord-299949-kmn53e2z 292 43 of of IN cord-299949-kmn53e2z 292 44 the the DT cord-299949-kmn53e2z 292 45 mouse mouse NN cord-299949-kmn53e2z 292 46 following follow VBG cord-299949-kmn53e2z 292 47 infection infection NN cord-299949-kmn53e2z 292 48 with with IN cord-299949-kmn53e2z 292 49 the the DT cord-299949-kmn53e2z 292 50 demyelinating demyelinating JJ cord-299949-kmn53e2z 292 51 strain strain NN cord-299949-kmn53e2z 292 52 of of IN cord-299949-kmn53e2z 292 53 Semliki Semliki NNP cord-299949-kmn53e2z 292 54 Forest Forest NNP cord-299949-kmn53e2z 292 55 virus virus NN cord-299949-kmn53e2z 292 56 Kinetics Kinetics NNP cord-299949-kmn53e2z 292 57 of of IN cord-299949-kmn53e2z 292 58 cytokine cytokine NN cord-299949-kmn53e2z 292 59 mRNA mrna NN cord-299949-kmn53e2z 292 60 expression expression NN cord-299949-kmn53e2z 292 61 in in IN cord-299949-kmn53e2z 292 62 the the DT cord-299949-kmn53e2z 292 63 central central JJ cord-299949-kmn53e2z 292 64 nervous nervous JJ cord-299949-kmn53e2z 292 65 system system NN cord-299949-kmn53e2z 292 66 following follow VBG cord-299949-kmn53e2z 293 1 lethal lethal JJ cord-299949-kmn53e2z 293 2 and and CC cord-299949-kmn53e2z 293 3 nonlethal nonlethal JJ cord-299949-kmn53e2z 293 4 coronavirus coronavirus NN cord-299949-kmn53e2z 293 5 - - HYPH cord-299949-kmn53e2z 293 6 induced induce VBN cord-299949-kmn53e2z 293 7 acute acute JJ cord-299949-kmn53e2z 293 8 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 293 9 IFN IFN NNP cord-299949-kmn53e2z 293 10 - - HYPH cord-299949-kmn53e2z 293 11 g g NNP cord-299949-kmn53e2z 293 12 is be VBZ cord-299949-kmn53e2z 293 13 required require VBN cord-299949-kmn53e2z 293 14 for for IN cord-299949-kmn53e2z 293 15 viral viral JJ cord-299949-kmn53e2z 293 16 clearance clearance NN cord-299949-kmn53e2z 293 17 from from IN cord-299949-kmn53e2z 293 18 central central JJ cord-299949-kmn53e2z 293 19 nervous nervous JJ cord-299949-kmn53e2z 293 20 system system NN cord-299949-kmn53e2z 293 21 oligodendroglia oligodendroglia NNP cord-299949-kmn53e2z 293 22 Cytokine cytokine NN cord-299949-kmn53e2z 293 23 induction induction NN cord-299949-kmn53e2z 293 24 during during IN cord-299949-kmn53e2z 293 25 T t NN cord-299949-kmn53e2z 293 26 - - HYPH cord-299949-kmn53e2z 293 27 cell cell NN cord-299949-kmn53e2z 293 28 - - HYPH cord-299949-kmn53e2z 293 29 mediated mediate VBN cord-299949-kmn53e2z 293 30 clearance clearance NN cord-299949-kmn53e2z 293 31 of of IN cord-299949-kmn53e2z 293 32 mouse mouse NN cord-299949-kmn53e2z 293 33 hepatitis hepatitis NN cord-299949-kmn53e2z 293 34 virus virus NN cord-299949-kmn53e2z 293 35 from from IN cord-299949-kmn53e2z 293 36 neurons neuron NNS cord-299949-kmn53e2z 293 37 in in IN cord-299949-kmn53e2z 293 38 vivo vivo NN cord-299949-kmn53e2z 294 1 Neurotropic Neurotropic NNP cord-299949-kmn53e2z 294 2 arboviruses arbovirus NNS cord-299949-kmn53e2z 294 3 induce induce VBP cord-299949-kmn53e2z 294 4 interferon interferon NN cord-299949-kmn53e2z 294 5 regulatory regulatory JJ cord-299949-kmn53e2z 294 6 factor factor NN cord-299949-kmn53e2z 294 7 3-mediated 3-mediated CD cord-299949-kmn53e2z 294 8 neuronal neuronal JJ cord-299949-kmn53e2z 294 9 responses response NNS cord-299949-kmn53e2z 294 10 that that WDT cord-299949-kmn53e2z 294 11 are be VBP cord-299949-kmn53e2z 294 12 cytoprotective cytoprotective JJ cord-299949-kmn53e2z 294 13 , , , cord-299949-kmn53e2z 294 14 interferon interferon NN cord-299949-kmn53e2z 294 15 independent independent JJ cord-299949-kmn53e2z 294 16 , , , cord-299949-kmn53e2z 294 17 and and CC cord-299949-kmn53e2z 294 18 inhibited inhibit VBN cord-299949-kmn53e2z 294 19 by by IN cord-299949-kmn53e2z 294 20 western western JJ cord-299949-kmn53e2z 294 21 equine equine JJ cord-299949-kmn53e2z 294 22 encephalitis encephalitis NN cord-299949-kmn53e2z 294 23 virus virus NN cord-299949-kmn53e2z 294 24 capsid capsid NN cord-299949-kmn53e2z 294 25 Human human JJ cord-299949-kmn53e2z 294 26 neuronal neuronal JJ cord-299949-kmn53e2z 294 27 cells cell NNS cord-299949-kmn53e2z 294 28 possess possess VBP cord-299949-kmn53e2z 294 29 functional functional JJ cord-299949-kmn53e2z 294 30 cytoplasmic cytoplasmic JJ cord-299949-kmn53e2z 294 31 and and CC cord-299949-kmn53e2z 294 32 TLR tlr NN cord-299949-kmn53e2z 294 33 - - HYPH cord-299949-kmn53e2z 294 34 mediated mediate VBN cord-299949-kmn53e2z 294 35 innate innate JJ cord-299949-kmn53e2z 294 36 immune immune JJ cord-299949-kmn53e2z 294 37 pathways pathway NNS cord-299949-kmn53e2z 294 38 influenced influence VBN cord-299949-kmn53e2z 294 39 by by IN cord-299949-kmn53e2z 294 40 phosphatidylinositol-3 phosphatidylinositol-3 NNP cord-299949-kmn53e2z 294 41 kinase kinase NN cord-299949-kmn53e2z 294 42 signaling signal VBG cord-299949-kmn53e2z 294 43 Multiplexed Multiplexed NNP cord-299949-kmn53e2z 294 44 digital digital NNP cord-299949-kmn53e2z 295 1 mRNA mrna NN cord-299949-kmn53e2z 295 2 profiling profiling NN cord-299949-kmn53e2z 295 3 of of IN cord-299949-kmn53e2z 295 4 the the DT cord-299949-kmn53e2z 295 5 inflammatory inflammatory JJ cord-299949-kmn53e2z 295 6 response response NN cord-299949-kmn53e2z 295 7 in in IN cord-299949-kmn53e2z 295 8 the the DT cord-299949-kmn53e2z 295 9 West West NNP cord-299949-kmn53e2z 295 10 Nile Nile NNP cord-299949-kmn53e2z 295 11 swiss swiss JJ cord-299949-kmn53e2z 295 12 webster webster NNP cord-299949-kmn53e2z 295 13 mouse mouse NN cord-299949-kmn53e2z 295 14 model model NN cord-299949-kmn53e2z 295 15 Progression Progression NNP cord-299949-kmn53e2z 295 16 from from IN cord-299949-kmn53e2z 295 17 IgD igd NN cord-299949-kmn53e2z 296 1 þ þ NNP cord-299949-kmn53e2z 296 2 IgM IgM NNP cord-299949-kmn53e2z 296 3 þ þ NNP cord-299949-kmn53e2z 296 4 to to IN cord-299949-kmn53e2z 296 5 isotype isotype NN cord-299949-kmn53e2z 296 6 - - HYPH cord-299949-kmn53e2z 296 7 switched switch VBN cord-299949-kmn53e2z 296 8 B b NN cord-299949-kmn53e2z 296 9 cells cell NNS cord-299949-kmn53e2z 296 10 is be VBZ cord-299949-kmn53e2z 296 11 site site NN cord-299949-kmn53e2z 296 12 specific specific JJ cord-299949-kmn53e2z 296 13 during during IN cord-299949-kmn53e2z 296 14 coronavirus coronavirus NN cord-299949-kmn53e2z 296 15 - - HYPH cord-299949-kmn53e2z 296 16 induced induce VBN cord-299949-kmn53e2z 296 17 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 296 18 Regional regional JJ cord-299949-kmn53e2z 296 19 differences difference NNS cord-299949-kmn53e2z 296 20 in in IN cord-299949-kmn53e2z 296 21 blood blood NN cord-299949-kmn53e2z 296 22 - - HYPH cord-299949-kmn53e2z 296 23 brain brain NN cord-299949-kmn53e2z 296 24 barrier barrier NN cord-299949-kmn53e2z 296 25 permeability permeability NN cord-299949-kmn53e2z 296 26 changes change NNS cord-299949-kmn53e2z 296 27 and and CC cord-299949-kmn53e2z 296 28 inflammation inflammation NN cord-299949-kmn53e2z 296 29 in in IN cord-299949-kmn53e2z 296 30 the the DT cord-299949-kmn53e2z 296 31 apathogenic apathogenic JJ cord-299949-kmn53e2z 296 32 clearance clearance NN cord-299949-kmn53e2z 296 33 of of IN cord-299949-kmn53e2z 296 34 virus virus NN cord-299949-kmn53e2z 296 35 from from IN cord-299949-kmn53e2z 296 36 the the DT cord-299949-kmn53e2z 296 37 central central JJ cord-299949-kmn53e2z 296 38 nervous nervous JJ cord-299949-kmn53e2z 296 39 system system NN cord-299949-kmn53e2z 296 40 Factors factor NNS cord-299949-kmn53e2z 296 41 supporting support VBG cord-299949-kmn53e2z 296 42 intrathecal intrathecal JJ cord-299949-kmn53e2z 296 43 humoral humoral JJ cord-299949-kmn53e2z 296 44 responses response NNS cord-299949-kmn53e2z 296 45 following follow VBG cord-299949-kmn53e2z 296 46 viral viral JJ cord-299949-kmn53e2z 296 47 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 296 48 Astrocyte Astrocyte NNP cord-299949-kmn53e2z 296 49 - - HYPH cord-299949-kmn53e2z 296 50 derived derive VBN cord-299949-kmn53e2z 296 51 CXCL10 CXCL10 NNP cord-299949-kmn53e2z 296 52 drives drive VBZ cord-299949-kmn53e2z 296 53 accumulation accumulation NN cord-299949-kmn53e2z 296 54 of of IN cord-299949-kmn53e2z 296 55 antibody antibody NN cord-299949-kmn53e2z 296 56 - - HYPH cord-299949-kmn53e2z 296 57 secreting secrete VBG cord-299949-kmn53e2z 296 58 cells cell NNS cord-299949-kmn53e2z 296 59 in in IN cord-299949-kmn53e2z 296 60 the the DT cord-299949-kmn53e2z 296 61 central central JJ cord-299949-kmn53e2z 296 62 nervous nervous JJ cord-299949-kmn53e2z 296 63 system system NN cord-299949-kmn53e2z 296 64 during during IN cord-299949-kmn53e2z 296 65 viral viral JJ cord-299949-kmn53e2z 296 66 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 296 67 Enhanced enhance VBN cord-299949-kmn53e2z 296 68 antiviral antiviral JJ cord-299949-kmn53e2z 296 69 T T NNP cord-299949-kmn53e2z 296 70 cell cell NN cord-299949-kmn53e2z 296 71 function function NN cord-299949-kmn53e2z 296 72 in in IN cord-299949-kmn53e2z 296 73 the the DT cord-299949-kmn53e2z 296 74 absence absence NN cord-299949-kmn53e2z 296 75 of of IN cord-299949-kmn53e2z 296 76 B7-H1 B7-H1 NNP cord-299949-kmn53e2z 297 1 is be VBZ cord-299949-kmn53e2z 297 2 insufficient insufficient JJ cord-299949-kmn53e2z 297 3 to to TO cord-299949-kmn53e2z 297 4 prevent prevent VB cord-299949-kmn53e2z 297 5 persistence persistence NN cord-299949-kmn53e2z 297 6 but but CC cord-299949-kmn53e2z 297 7 exacerbates exacerbate VBZ cord-299949-kmn53e2z 297 8 axonal axonal JJ cord-299949-kmn53e2z 297 9 bystander bystander NN cord-299949-kmn53e2z 297 10 damage damage NN cord-299949-kmn53e2z 297 11 during during IN cord-299949-kmn53e2z 297 12 viral viral JJ cord-299949-kmn53e2z 297 13 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 297 14 Bioluminescent Bioluminescent NNP cord-299949-kmn53e2z 297 15 imaging imaging NN cord-299949-kmn53e2z 297 16 and and CC cord-299949-kmn53e2z 297 17 histopathologic histopathologic JJ cord-299949-kmn53e2z 297 18 characterization characterization NN cord-299949-kmn53e2z 297 19 of of IN cord-299949-kmn53e2z 297 20 WEEV WEEV NNP cord-299949-kmn53e2z 297 21 neuroinvasion neuroinvasion NN cord-299949-kmn53e2z 297 22 in in IN cord-299949-kmn53e2z 297 23 outbred outbred JJ cord-299949-kmn53e2z 297 24 CD-1 CD-1 NNP cord-299949-kmn53e2z 297 25 mice mouse NNS cord-299949-kmn53e2z 297 26 Virus Virus NNP cord-299949-kmn53e2z 297 27 infection infection NN cord-299949-kmn53e2z 298 1 switches switch NNS cord-299949-kmn53e2z 298 2 TLR-3-positive TLR-3-positive NNP cord-299949-kmn53e2z 298 3 human human JJ cord-299949-kmn53e2z 298 4 neurons neuron NNS cord-299949-kmn53e2z 298 5 to to TO cord-299949-kmn53e2z 298 6 become become VB cord-299949-kmn53e2z 298 7 strong strong JJ cord-299949-kmn53e2z 298 8 producers producer NNS cord-299949-kmn53e2z 298 9 of of IN cord-299949-kmn53e2z 298 10 beta beta NN cord-299949-kmn53e2z 298 11 interferon interferon NN cord-299949-kmn53e2z 299 1 The the DT cord-299949-kmn53e2z 299 2 inflammatory inflammatory JJ cord-299949-kmn53e2z 299 3 cytokine cytokine NN cord-299949-kmn53e2z 299 4 , , , cord-299949-kmn53e2z 299 5 interleukin-1 interleukin-1 NN cord-299949-kmn53e2z 299 6 beta beta NN cord-299949-kmn53e2z 299 7 , , , cord-299949-kmn53e2z 299 8 mediates mediate VBZ cord-299949-kmn53e2z 299 9 loss loss NN cord-299949-kmn53e2z 299 10 of of IN cord-299949-kmn53e2z 299 11 astroglial astroglial JJ cord-299949-kmn53e2z 299 12 glutamate glutamate NN cord-299949-kmn53e2z 299 13 transport transport NN cord-299949-kmn53e2z 299 14 and and CC cord-299949-kmn53e2z 299 15 drives drive VBZ cord-299949-kmn53e2z 299 16 excitotoxic excitotoxic JJ cord-299949-kmn53e2z 299 17 motor motor NN cord-299949-kmn53e2z 299 18 neuron neuron NN cord-299949-kmn53e2z 299 19 injury injury NN cord-299949-kmn53e2z 299 20 in in IN cord-299949-kmn53e2z 299 21 the the DT cord-299949-kmn53e2z 299 22 spinal spinal JJ cord-299949-kmn53e2z 299 23 cord cord NN cord-299949-kmn53e2z 299 24 during during IN cord-299949-kmn53e2z 299 25 acute acute JJ cord-299949-kmn53e2z 299 26 viral viral JJ cord-299949-kmn53e2z 299 27 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 299 28 The the DT cord-299949-kmn53e2z 299 29 lymphoid lymphoid JJ cord-299949-kmn53e2z 299 30 chemokine chemokine NN cord-299949-kmn53e2z 299 31 , , , cord-299949-kmn53e2z 299 32 CXCL13 CXCL13 NNP cord-299949-kmn53e2z 299 33 , , , cord-299949-kmn53e2z 299 34 is be VBZ cord-299949-kmn53e2z 299 35 dispensable dispensable JJ cord-299949-kmn53e2z 299 36 for for IN cord-299949-kmn53e2z 299 37 the the DT cord-299949-kmn53e2z 299 38 initial initial JJ cord-299949-kmn53e2z 299 39 recruitment recruitment NN cord-299949-kmn53e2z 299 40 of of IN cord-299949-kmn53e2z 299 41 B b NN cord-299949-kmn53e2z 299 42 cells cell NNS cord-299949-kmn53e2z 299 43 to to IN cord-299949-kmn53e2z 299 44 the the DT cord-299949-kmn53e2z 299 45 acutely acutely RB cord-299949-kmn53e2z 299 46 inflamed inflamed JJ cord-299949-kmn53e2z 299 47 central central JJ cord-299949-kmn53e2z 299 48 nervous nervous JJ cord-299949-kmn53e2z 299 49 system system NN cord-299949-kmn53e2z 299 50 Differential differential JJ cord-299949-kmn53e2z 299 51 regulation regulation NN cord-299949-kmn53e2z 299 52 of of IN cord-299949-kmn53e2z 299 53 primary primary JJ cord-299949-kmn53e2z 299 54 and and CC cord-299949-kmn53e2z 299 55 secondary secondary JJ cord-299949-kmn53e2z 299 56 CD8 CD8 NNP cord-299949-kmn53e2z 299 57 þ þ NNP cord-299949-kmn53e2z 299 58 T T NNP cord-299949-kmn53e2z 299 59 cells cell NNS cord-299949-kmn53e2z 299 60 in in IN cord-299949-kmn53e2z 299 61 the the DT cord-299949-kmn53e2z 299 62 central central JJ cord-299949-kmn53e2z 299 63 nervous nervous JJ cord-299949-kmn53e2z 299 64 system system NN cord-299949-kmn53e2z 299 65 Mechanisms Mechanisms NNPS cord-299949-kmn53e2z 299 66 of of IN cord-299949-kmn53e2z 299 67 central central JJ cord-299949-kmn53e2z 299 68 nervous nervous JJ cord-299949-kmn53e2z 299 69 system system NN cord-299949-kmn53e2z 299 70 viral viral JJ cord-299949-kmn53e2z 299 71 persistence persistence NN cord-299949-kmn53e2z 299 72 : : : cord-299949-kmn53e2z 299 73 the the DT cord-299949-kmn53e2z 299 74 critical critical JJ cord-299949-kmn53e2z 299 75 role role NN cord-299949-kmn53e2z 299 76 of of IN cord-299949-kmn53e2z 299 77 antibody antibody NN cord-299949-kmn53e2z 299 78 and and CC cord-299949-kmn53e2z 299 79 B b NN cord-299949-kmn53e2z 299 80 cells cell NNS cord-299949-kmn53e2z 300 1 IL-1b IL-1b NNP cord-299949-kmn53e2z 300 2 signaling signal VBG cord-299949-kmn53e2z 300 3 promotes promote VBZ cord-299949-kmn53e2z 300 4 CNS CNS NNP cord-299949-kmn53e2z 300 5 - - HYPH cord-299949-kmn53e2z 300 6 intrinsic intrinsic JJ cord-299949-kmn53e2z 300 7 immune immune JJ cord-299949-kmn53e2z 300 8 control control NN cord-299949-kmn53e2z 300 9 of of IN cord-299949-kmn53e2z 300 10 West West NNP cord-299949-kmn53e2z 300 11 Nile Nile NNP cord-299949-kmn53e2z 300 12 virus virus NN cord-299949-kmn53e2z 300 13 infection infection NN cord-299949-kmn53e2z 301 1 The the DT cord-299949-kmn53e2z 301 2 myeloid myeloid NN cord-299949-kmn53e2z 301 3 cells cell NNS cord-299949-kmn53e2z 301 4 of of IN cord-299949-kmn53e2z 301 5 the the DT cord-299949-kmn53e2z 301 6 central central JJ cord-299949-kmn53e2z 301 7 nervous nervous JJ cord-299949-kmn53e2z 301 8 system system NN cord-299949-kmn53e2z 302 1 parenchyma parenchyma NNP cord-299949-kmn53e2z 302 2 Interferon Interferon NNP cord-299949-kmn53e2z 302 3 modulates modulate VBZ cord-299949-kmn53e2z 302 4 central central JJ cord-299949-kmn53e2z 302 5 nervous nervous JJ cord-299949-kmn53e2z 302 6 system system NN cord-299949-kmn53e2z 302 7 function function NN cord-299949-kmn53e2z 303 1 Enterovirus enterovirus NN cord-299949-kmn53e2z 303 2 infections infection NNS cord-299949-kmn53e2z 303 3 of of IN cord-299949-kmn53e2z 303 4 the the DT cord-299949-kmn53e2z 303 5 central central JJ cord-299949-kmn53e2z 303 6 nervous nervous JJ cord-299949-kmn53e2z 303 7 system system NN cord-299949-kmn53e2z 303 8 Interferon interferon NN cord-299949-kmn53e2z 303 9 - - HYPH cord-299949-kmn53e2z 303 10 gamma gamma NN cord-299949-kmn53e2z 303 11 prevents prevent VBZ cord-299949-kmn53e2z 303 12 death death NN cord-299949-kmn53e2z 303 13 of of IN cord-299949-kmn53e2z 303 14 bystander bystander NN cord-299949-kmn53e2z 303 15 neurons neuron NNS cord-299949-kmn53e2z 303 16 during during IN cord-299949-kmn53e2z 303 17 CD8 CD8 NNP cord-299949-kmn53e2z 303 18 T T NNP cord-299949-kmn53e2z 303 19 cell cell NN cord-299949-kmn53e2z 303 20 responses response NNS cord-299949-kmn53e2z 303 21 in in IN cord-299949-kmn53e2z 303 22 the the DT cord-299949-kmn53e2z 303 23 brain brain NN cord-299949-kmn53e2z 304 1 The the DT cord-299949-kmn53e2z 304 2 inflammatory inflammatory JJ cord-299949-kmn53e2z 304 3 response response NN cord-299949-kmn53e2z 304 4 to to IN cord-299949-kmn53e2z 304 5 nonfatal nonfatal JJ cord-299949-kmn53e2z 304 6 sindbis sindbis NN cord-299949-kmn53e2z 304 7 virus virus NN cord-299949-kmn53e2z 304 8 infection infection NN cord-299949-kmn53e2z 304 9 of of IN cord-299949-kmn53e2z 304 10 the the DT cord-299949-kmn53e2z 304 11 nervous nervous JJ cord-299949-kmn53e2z 304 12 system system NN cord-299949-kmn53e2z 304 13 is be VBZ cord-299949-kmn53e2z 304 14 more more RBR cord-299949-kmn53e2z 304 15 severe severe JJ cord-299949-kmn53e2z 304 16 in in IN cord-299949-kmn53e2z 304 17 SJL SJL NNP cord-299949-kmn53e2z 304 18 than than IN cord-299949-kmn53e2z 304 19 in in IN cord-299949-kmn53e2z 304 20 BALB BALB NNP cord-299949-kmn53e2z 304 21 / / SYM cord-299949-kmn53e2z 304 22 C C NNP cord-299949-kmn53e2z 304 23 mice mouse NNS cord-299949-kmn53e2z 304 24 and and CC cord-299949-kmn53e2z 304 25 is be VBZ cord-299949-kmn53e2z 304 26 associated associate VBN cord-299949-kmn53e2z 304 27 with with IN cord-299949-kmn53e2z 304 28 low low JJ cord-299949-kmn53e2z 304 29 levels level NNS cord-299949-kmn53e2z 304 30 of of IN cord-299949-kmn53e2z 304 31 IL-4 IL-4 NNP cord-299949-kmn53e2z 304 32 mRNA mRNA NNP cord-299949-kmn53e2z 304 33 and and CC cord-299949-kmn53e2z 304 34 high high JJ cord-299949-kmn53e2z 304 35 levels level NNS cord-299949-kmn53e2z 304 36 of of IN cord-299949-kmn53e2z 304 37 IL-10-Producing il-10-producing CD cord-299949-kmn53e2z 305 1 CD4 CD4 NNP cord-299949-kmn53e2z 305 2 þ þ NNP cord-299949-kmn53e2z 305 3 T t NN cord-299949-kmn53e2z 305 4 cells cell NNS cord-299949-kmn53e2z 306 1 Contribution contribution NN cord-299949-kmn53e2z 306 2 of of IN cord-299949-kmn53e2z 306 3 T T NNP cord-299949-kmn53e2z 306 4 cells cell NNS cord-299949-kmn53e2z 306 5 to to IN cord-299949-kmn53e2z 306 6 mortality mortality NN cord-299949-kmn53e2z 306 7 in in IN cord-299949-kmn53e2z 306 8 neurovirulent neurovirulent NNP cord-299949-kmn53e2z 306 9 sindbis sindbis NNP cord-299949-kmn53e2z 306 10 virus virus NNP cord-299949-kmn53e2z 306 11 encephalomyelitis encephalomyelitis NNP cord-299949-kmn53e2z 307 1 Alpha/ alpha/ NN cord-299949-kmn53e2z 307 2 Beta beta NN cord-299949-kmn53e2z 307 3 interferon interferon NN cord-299949-kmn53e2z 307 4 protects protect VBZ cord-299949-kmn53e2z 307 5 adult adult NN cord-299949-kmn53e2z 307 6 mice mouse NNS cord-299949-kmn53e2z 307 7 from from IN cord-299949-kmn53e2z 307 8 fatal fatal JJ cord-299949-kmn53e2z 307 9 sindbis sindbis NN cord-299949-kmn53e2z 307 10 virus virus NN cord-299949-kmn53e2z 307 11 infection infection NN cord-299949-kmn53e2z 307 12 and and CC cord-299949-kmn53e2z 307 13 is be VBZ cord-299949-kmn53e2z 307 14 an an DT cord-299949-kmn53e2z 307 15 important important JJ cord-299949-kmn53e2z 307 16 determinant determinant NN cord-299949-kmn53e2z 307 17 of of IN cord-299949-kmn53e2z 307 18 cell cell NN cord-299949-kmn53e2z 307 19 and and CC cord-299949-kmn53e2z 307 20 tissue tissue NN cord-299949-kmn53e2z 307 21 tropism tropism NN cord-299949-kmn53e2z 307 22 Evidence evidence NN cord-299949-kmn53e2z 307 23 for for IN cord-299949-kmn53e2z 307 24 influenza influenza NN cord-299949-kmn53e2z 307 25 virus virus NN cord-299949-kmn53e2z 307 26 CNS CNS NNP cord-299949-kmn53e2z 307 27 invasion invasion NN cord-299949-kmn53e2z 307 28 along along IN cord-299949-kmn53e2z 307 29 the the DT cord-299949-kmn53e2z 307 30 olfactory olfactory JJ cord-299949-kmn53e2z 307 31 route route NN cord-299949-kmn53e2z 307 32 in in IN cord-299949-kmn53e2z 307 33 an an DT cord-299949-kmn53e2z 307 34 immunocompromised immunocompromised JJ cord-299949-kmn53e2z 307 35 infant infant NN cord-299949-kmn53e2z 307 36 A a DT cord-299949-kmn53e2z 307 37 Hitchhiker Hitchhiker NNP cord-299949-kmn53e2z 307 38 's 's POS cord-299949-kmn53e2z 307 39 guide guide NN cord-299949-kmn53e2z 307 40 to to IN cord-299949-kmn53e2z 307 41 the the DT cord-299949-kmn53e2z 307 42 nervous nervous JJ cord-299949-kmn53e2z 307 43 system system NN cord-299949-kmn53e2z 307 44 : : : cord-299949-kmn53e2z 307 45 the the DT cord-299949-kmn53e2z 307 46 complex complex JJ cord-299949-kmn53e2z 307 47 journey journey NN cord-299949-kmn53e2z 307 48 of of IN cord-299949-kmn53e2z 307 49 viruses virus NNS cord-299949-kmn53e2z 307 50 and and CC cord-299949-kmn53e2z 307 51 toxins toxin NNS cord-299949-kmn53e2z 308 1 Alpha alpha NN cord-299949-kmn53e2z 308 2 / / SYM cord-299949-kmn53e2z 308 3 beta beta NN cord-299949-kmn53e2z 308 4 interferon interferon NN cord-299949-kmn53e2z 308 5 protects protect VBZ cord-299949-kmn53e2z 308 6 against against IN cord-299949-kmn53e2z 308 7 lethal lethal JJ cord-299949-kmn53e2z 308 8 West West NNP cord-299949-kmn53e2z 308 9 Nile Nile NNP cord-299949-kmn53e2z 308 10 virus virus NN cord-299949-kmn53e2z 308 11 infection infection NN cord-299949-kmn53e2z 308 12 by by IN cord-299949-kmn53e2z 308 13 restricting restrict VBG cord-299949-kmn53e2z 308 14 cellular cellular JJ cord-299949-kmn53e2z 308 15 tropism tropism NN cord-299949-kmn53e2z 308 16 and and CC cord-299949-kmn53e2z 308 17 enhancing enhance VBG cord-299949-kmn53e2z 308 18 neuronal neuronal JJ cord-299949-kmn53e2z 308 19 survival survival NN cord-299949-kmn53e2z 308 20 Learning learn VBG cord-299949-kmn53e2z 308 21 deficits deficit NNS cord-299949-kmn53e2z 308 22 in in IN cord-299949-kmn53e2z 308 23 mice mouse NNS cord-299949-kmn53e2z 308 24 with with IN cord-299949-kmn53e2z 308 25 persistent persistent JJ cord-299949-kmn53e2z 308 26 borna borna NNP cord-299949-kmn53e2z 308 27 disease disease NNP cord-299949-kmn53e2z 308 28 virus virus NN cord-299949-kmn53e2z 308 29 infection infection NN cord-299949-kmn53e2z 308 30 of of IN cord-299949-kmn53e2z 308 31 the the DT cord-299949-kmn53e2z 308 32 CNS CNS NNP cord-299949-kmn53e2z 308 33 associated associate VBN cord-299949-kmn53e2z 308 34 with with IN cord-299949-kmn53e2z 308 35 elevated elevated JJ cord-299949-kmn53e2z 308 36 chemokine chemokine NN cord-299949-kmn53e2z 308 37 expression expression NN cord-299949-kmn53e2z 309 1 A a DT cord-299949-kmn53e2z 309 2 diverse diverse JJ cord-299949-kmn53e2z 309 3 range range NN cord-299949-kmn53e2z 309 4 of of IN cord-299949-kmn53e2z 309 5 gene gene NN cord-299949-kmn53e2z 309 6 products product NNS cord-299949-kmn53e2z 309 7 are be VBP cord-299949-kmn53e2z 309 8 effectors effector NNS cord-299949-kmn53e2z 309 9 of of IN cord-299949-kmn53e2z 309 10 the the DT cord-299949-kmn53e2z 309 11 type type NN cord-299949-kmn53e2z 310 1 I -PRON- PRP cord-299949-kmn53e2z 310 2 interferon interferon VBP cord-299949-kmn53e2z 310 3 antiviral antiviral JJ cord-299949-kmn53e2z 310 4 response response NN cord-299949-kmn53e2z 311 1 Differentiation differentiation NN cord-299949-kmn53e2z 311 2 of of IN cord-299949-kmn53e2z 311 3 neurons neuron NNS cord-299949-kmn53e2z 311 4 restricts restrict VBZ cord-299949-kmn53e2z 311 5 arbovirus arbovirus NN cord-299949-kmn53e2z 311 6 replication replication NN cord-299949-kmn53e2z 311 7 and and CC cord-299949-kmn53e2z 311 8 increases increase VBZ cord-299949-kmn53e2z 311 9 expression expression NN cord-299949-kmn53e2z 311 10 of of IN cord-299949-kmn53e2z 311 11 the the DT cord-299949-kmn53e2z 311 12 alpha alpha NN cord-299949-kmn53e2z 311 13 isoform isoform NN cord-299949-kmn53e2z 311 14 of of IN cord-299949-kmn53e2z 311 15 IRF-7 IRF-7 NNP cord-299949-kmn53e2z 312 1 How how WRB cord-299949-kmn53e2z 312 2 do do VBP cord-299949-kmn53e2z 312 3 immune immune JJ cord-299949-kmn53e2z 312 4 cells cell NNS cord-299949-kmn53e2z 312 5 support support NN cord-299949-kmn53e2z 312 6 and and CC cord-299949-kmn53e2z 312 7 shape shape VB cord-299949-kmn53e2z 312 8 the the DT cord-299949-kmn53e2z 312 9 brain brain NN cord-299949-kmn53e2z 312 10 in in IN cord-299949-kmn53e2z 312 11 health health NN cord-299949-kmn53e2z 312 12 , , , cord-299949-kmn53e2z 312 13 disease disease NN cord-299949-kmn53e2z 312 14 , , , cord-299949-kmn53e2z 312 15 and and CC cord-299949-kmn53e2z 312 16 aging age VBG cord-299949-kmn53e2z 312 17 ? ? . cord-299949-kmn53e2z 313 1 Tumor tumor NN cord-299949-kmn53e2z 313 2 necrosis necrosis NN cord-299949-kmn53e2z 313 3 factor factor NN cord-299949-kmn53e2z 313 4 - - : cord-299949-kmn53e2z 313 5 A a NN cord-299949-kmn53e2z 313 6 and and CC cord-299949-kmn53e2z 313 7 interleukin interleukin NN cord-299949-kmn53e2z 313 8 -1b -1b NNS cord-299949-kmn53e2z 313 9 play play VBP cord-299949-kmn53e2z 313 10 a a DT cord-299949-kmn53e2z 313 11 critical critical JJ cord-299949-kmn53e2z 313 12 role role NN cord-299949-kmn53e2z 313 13 in in IN cord-299949-kmn53e2z 313 14 the the DT cord-299949-kmn53e2z 313 15 resistance resistance NN cord-299949-kmn53e2z 313 16 against against IN cord-299949-kmn53e2z 313 17 lethal lethal JJ cord-299949-kmn53e2z 313 18 herpes herpe NNS cord-299949-kmn53e2z 314 1 simplex simplex NNP cord-299949-kmn53e2z 314 2 virus virus NN cord-299949-kmn53e2z 314 3 encephalitis encephalitis NN cord-299949-kmn53e2z 314 4 Fas Fas NNP cord-299949-kmn53e2z 314 5 ligand ligand NN cord-299949-kmn53e2z 314 6 interactions interaction NNS cord-299949-kmn53e2z 314 7 contribute contribute VBP cord-299949-kmn53e2z 314 8 to to IN cord-299949-kmn53e2z 314 9 CD8 CD8 NNP cord-299949-kmn53e2z 314 10 þ þ NNP cord-299949-kmn53e2z 314 11 T T NNP cord-299949-kmn53e2z 314 12 - - HYPH cord-299949-kmn53e2z 314 13 cellmediated cellmediate VBN cord-299949-kmn53e2z 314 14 control control NN cord-299949-kmn53e2z 314 15 of of IN cord-299949-kmn53e2z 314 16 West West NNP cord-299949-kmn53e2z 314 17 Nile Nile NNP cord-299949-kmn53e2z 314 18 virus virus NN cord-299949-kmn53e2z 314 19 infection infection NN cord-299949-kmn53e2z 314 20 in in IN cord-299949-kmn53e2z 314 21 the the DT cord-299949-kmn53e2z 314 22 central central JJ cord-299949-kmn53e2z 314 23 nervous nervous JJ cord-299949-kmn53e2z 314 24 system system NN cord-299949-kmn53e2z 315 1 CD8 CD8 NNP cord-299949-kmn53e2z 315 2 þ þ NNP cord-299949-kmn53e2z 315 3 T T NNP cord-299949-kmn53e2z 315 4 cells cell NNS cord-299949-kmn53e2z 315 5 use use VBP cord-299949-kmn53e2z 315 6 TRAIL TRAIL NNP cord-299949-kmn53e2z 315 7 to to TO cord-299949-kmn53e2z 315 8 restrict restrict VB cord-299949-kmn53e2z 315 9 West West NNP cord-299949-kmn53e2z 315 10 Nile Nile NNP cord-299949-kmn53e2z 315 11 virus virus NN cord-299949-kmn53e2z 315 12 pathogenesis pathogenesis NN cord-299949-kmn53e2z 315 13 by by IN cord-299949-kmn53e2z 315 14 controlling control VBG cord-299949-kmn53e2z 315 15 infection infection NN cord-299949-kmn53e2z 315 16 in in IN cord-299949-kmn53e2z 315 17 neurons neuron NNS cord-299949-kmn53e2z 316 1 Gamma gamma NN cord-299949-kmn53e2z 316 2 interferon interferon NN cord-299949-kmn53e2z 316 3 plays play VBZ cord-299949-kmn53e2z 316 4 a a DT cord-299949-kmn53e2z 316 5 crucial crucial JJ cord-299949-kmn53e2z 316 6 early early JJ cord-299949-kmn53e2z 316 7 antiviral antiviral JJ cord-299949-kmn53e2z 316 8 role role NN cord-299949-kmn53e2z 316 9 in in IN cord-299949-kmn53e2z 316 10 protection protection NN cord-299949-kmn53e2z 316 11 against against IN cord-299949-kmn53e2z 316 12 West West NNP cord-299949-kmn53e2z 316 13 Nile Nile NNP cord-299949-kmn53e2z 316 14 virus virus NN cord-299949-kmn53e2z 316 15 infection infection NN cord-299949-kmn53e2z 316 16 Eastern eastern JJ cord-299949-kmn53e2z 316 17 equine equine NN cord-299949-kmn53e2z 316 18 encephalitis encephalitis RB cord-299949-kmn53e2z 316 19 in in IN cord-299949-kmn53e2z 316 20 children child NNS cord-299949-kmn53e2z 316 21 CD40-CD40 cd40-cd40 IN cord-299949-kmn53e2z 316 22 ligand ligand NN cord-299949-kmn53e2z 316 23 interactions interaction NNS cord-299949-kmn53e2z 316 24 promote promote VBP cord-299949-kmn53e2z 316 25 trafficking trafficking NN cord-299949-kmn53e2z 316 26 of of IN cord-299949-kmn53e2z 316 27 CD8 CD8 NNP cord-299949-kmn53e2z 316 28 þ þ NNP cord-299949-kmn53e2z 316 29 T T NNP cord-299949-kmn53e2z 316 30 cells cell NNS cord-299949-kmn53e2z 316 31 into into IN cord-299949-kmn53e2z 316 32 the the DT cord-299949-kmn53e2z 316 33 brain brain NN cord-299949-kmn53e2z 316 34 and and CC cord-299949-kmn53e2z 316 35 protection protection NN cord-299949-kmn53e2z 316 36 against against IN cord-299949-kmn53e2z 316 37 West West NNP cord-299949-kmn53e2z 316 38 Nile Nile NNP cord-299949-kmn53e2z 316 39 virus virus NN cord-299949-kmn53e2z 316 40 encephalitis encephalitis RB cord-299949-kmn53e2z 316 41 Theiler Theiler NNP cord-299949-kmn53e2z 316 42 's 's POS cord-299949-kmn53e2z 316 43 virus virus NN cord-299949-kmn53e2z 316 44 infection infection NN cord-299949-kmn53e2z 317 1 induces induce VBZ cord-299949-kmn53e2z 317 2 TLR3-dependent TLR3-dependent NNP cord-299949-kmn53e2z 317 3 upregulation upregulation NN cord-299949-kmn53e2z 317 4 of of IN cord-299949-kmn53e2z 317 5 TLR2 TLR2 NNP cord-299949-kmn53e2z 317 6 critical critical JJ cord-299949-kmn53e2z 317 7 for for IN cord-299949-kmn53e2z 317 8 proinflammatory proinflammatory JJ cord-299949-kmn53e2z 317 9 cytokine cytokine NN cord-299949-kmn53e2z 317 10 production production NN cord-299949-kmn53e2z 317 11 Persistence persistence NN cord-299949-kmn53e2z 317 12 of of IN cord-299949-kmn53e2z 317 13 virus virus NN cord-299949-kmn53e2z 317 14 - - HYPH cord-299949-kmn53e2z 317 15 specific specific JJ cord-299949-kmn53e2z 317 16 immune immune JJ cord-299949-kmn53e2z 317 17 responses response NNS cord-299949-kmn53e2z 317 18 in in IN cord-299949-kmn53e2z 317 19 the the DT cord-299949-kmn53e2z 317 20 central central JJ cord-299949-kmn53e2z 317 21 nervous nervous JJ cord-299949-kmn53e2z 317 22 system system NN cord-299949-kmn53e2z 317 23 of of IN cord-299949-kmn53e2z 317 24 mice mouse NNS cord-299949-kmn53e2z 317 25 after after IN cord-299949-kmn53e2z 317 26 West West NNP cord-299949-kmn53e2z 317 27 Nile Nile NNP cord-299949-kmn53e2z 317 28 virus virus NN cord-299949-kmn53e2z 317 29 infection infection NN cord-299949-kmn53e2z 317 30 CTL CTL NNP cord-299949-kmn53e2z 317 31 effector effector NN cord-299949-kmn53e2z 317 32 function function NN cord-299949-kmn53e2z 317 33 within within IN cord-299949-kmn53e2z 317 34 the the DT cord-299949-kmn53e2z 317 35 central central JJ cord-299949-kmn53e2z 317 36 nervous nervous JJ cord-299949-kmn53e2z 317 37 system system NN cord-299949-kmn53e2z 317 38 requires require VBZ cord-299949-kmn53e2z 317 39 CD4 CD4 NNP cord-299949-kmn53e2z 317 40 þ þ NNP cord-299949-kmn53e2z 317 41 T t NN cord-299949-kmn53e2z 317 42 cells cell VBZ cord-299949-kmn53e2z 317 43 Mouse Mouse NNP cord-299949-kmn53e2z 317 44 hepatitis hepatitis NN cord-299949-kmn53e2z 317 45 virus virus NN cord-299949-kmn53e2z 317 46 - - HYPH cord-299949-kmn53e2z 317 47 specific specific JJ cord-299949-kmn53e2z 317 48 cytotoxic cytotoxic JJ cord-299949-kmn53e2z 317 49 T t NN cord-299949-kmn53e2z 317 50 lymphocytes lymphocyte NNS cord-299949-kmn53e2z 317 51 protect protect VBP cord-299949-kmn53e2z 317 52 from from IN cord-299949-kmn53e2z 317 53 lethal lethal JJ cord-299949-kmn53e2z 317 54 infection infection NN cord-299949-kmn53e2z 317 55 without without IN cord-299949-kmn53e2z 317 56 eliminating eliminate VBG cord-299949-kmn53e2z 317 57 virus virus NN cord-299949-kmn53e2z 317 58 from from IN cord-299949-kmn53e2z 317 59 the the DT cord-299949-kmn53e2z 317 60 central central JJ cord-299949-kmn53e2z 317 61 nervous nervous JJ cord-299949-kmn53e2z 317 62 system system NN cord-299949-kmn53e2z 317 63 T T NNP cord-299949-kmn53e2z 317 64 cell- cell- NN cord-299949-kmn53e2z 317 65 , , , cord-299949-kmn53e2z 317 66 interleukin-12- interleukin-12- NNPS cord-299949-kmn53e2z 317 67 , , , cord-299949-kmn53e2z 317 68 and and CC cord-299949-kmn53e2z 317 69 gamma gamma NN cord-299949-kmn53e2z 317 70 interferon interferon NN cord-299949-kmn53e2z 317 71 - - HYPH cord-299949-kmn53e2z 317 72 driven drive VBN cord-299949-kmn53e2z 317 73 viral viral JJ cord-299949-kmn53e2z 317 74 clearance clearance NN cord-299949-kmn53e2z 317 75 in in IN cord-299949-kmn53e2z 317 76 measles measle NNS cord-299949-kmn53e2z 317 77 virusinfected virusinfecte VBD cord-299949-kmn53e2z 317 78 brain brain NN cord-299949-kmn53e2z 317 79 tissue tissue NN cord-299949-kmn53e2z 317 80 Induction Induction NNP cord-299949-kmn53e2z 317 81 of of IN cord-299949-kmn53e2z 317 82 glial glial JJ cord-299949-kmn53e2z 317 83 cell cell NN cord-299949-kmn53e2z 317 84 MHC MHC NNP cord-299949-kmn53e2z 317 85 antigen antigen NN cord-299949-kmn53e2z 317 86 expression expression NN cord-299949-kmn53e2z 317 87 in in IN cord-299949-kmn53e2z 317 88 neurotropic neurotropic NNP cord-299949-kmn53e2z 317 89 coronavirus coronavirus NN cord-299949-kmn53e2z 317 90 infections infection NNS cord-299949-kmn53e2z 317 91 . . . cord-299949-kmn53e2z 318 1 Characterization characterization NN cord-299949-kmn53e2z 318 2 of of IN cord-299949-kmn53e2z 318 3 the the DT cord-299949-kmn53e2z 318 4 H-2-inducing h-2-induce VBG cord-299949-kmn53e2z 318 5 soluble soluble JJ cord-299949-kmn53e2z 318 6 factor factor NN cord-299949-kmn53e2z 318 7 elaborated elaborate VBN cord-299949-kmn53e2z 318 8 by by IN cord-299949-kmn53e2z 318 9 infected infected JJ cord-299949-kmn53e2z 318 10 brain brain NN cord-299949-kmn53e2z 318 11 cells cell NNS cord-299949-kmn53e2z 318 12 0 0 CD cord-299949-kmn53e2z 318 13 -O -O : cord-299949-kmn53e2z 318 14 methylation methylation NN cord-299949-kmn53e2z 318 15 of of IN cord-299949-kmn53e2z 318 16 the the DT cord-299949-kmn53e2z 318 17 viral viral JJ cord-299949-kmn53e2z 318 18 mRNA mRNA NNP cord-299949-kmn53e2z 318 19 cap cap NN cord-299949-kmn53e2z 318 20 by by IN cord-299949-kmn53e2z 318 21 West West NNP cord-299949-kmn53e2z 318 22 Nile Nile NNP cord-299949-kmn53e2z 318 23 virus virus NN cord-299949-kmn53e2z 318 24 evades evade VBZ cord-299949-kmn53e2z 318 25 IFIT1-dependent IFIT1-dependent NNP cord-299949-kmn53e2z 318 26 and and CC cord-299949-kmn53e2z 318 27 -independent -independent JJ cord-299949-kmn53e2z 318 28 mechanisms mechanism NNS cord-299949-kmn53e2z 318 29 of of IN cord-299949-kmn53e2z 318 30 host host NN cord-299949-kmn53e2z 318 31 restriction restriction NN cord-299949-kmn53e2z 318 32 in in IN cord-299949-kmn53e2z 318 33 vivo vivo NN cord-299949-kmn53e2z 318 34 Role role NN cord-299949-kmn53e2z 318 35 of of IN cord-299949-kmn53e2z 318 36 IFN IFN NNP cord-299949-kmn53e2z 318 37 - - HYPH cord-299949-kmn53e2z 318 38 g g NNP cord-299949-kmn53e2z 318 39 responsiveness responsiveness NN cord-299949-kmn53e2z 318 40 in in IN cord-299949-kmn53e2z 318 41 CD8 CD8 NNP cord-299949-kmn53e2z 318 42 T T NNP cord-299949-kmn53e2z 318 43 cellmediated cellmediate VBN cord-299949-kmn53e2z 318 44 viral viral JJ cord-299949-kmn53e2z 318 45 clearance clearance NN cord-299949-kmn53e2z 318 46 and and CC cord-299949-kmn53e2z 318 47 demyelination demyelination NN cord-299949-kmn53e2z 318 48 in in IN cord-299949-kmn53e2z 318 49 coronavirus coronavirus NN cord-299949-kmn53e2z 318 50 - - HYPH cord-299949-kmn53e2z 318 51 infected infect VBN cord-299949-kmn53e2z 318 52 mice mouse NNS cord-299949-kmn53e2z 319 1 Virally Virally NNP cord-299949-kmn53e2z 319 2 expressed express VBD cord-299949-kmn53e2z 319 3 interleukin-10 interleukin-10 NNP cord-299949-kmn53e2z 319 4 ameliorates ameliorate VBZ cord-299949-kmn53e2z 319 5 acute acute JJ cord-299949-kmn53e2z 319 6 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 319 7 and and CC cord-299949-kmn53e2z 319 8 chronic chronic JJ cord-299949-kmn53e2z 319 9 demyelination demyelination NN cord-299949-kmn53e2z 319 10 in in IN cord-299949-kmn53e2z 319 11 coronavirus coronavirus NN cord-299949-kmn53e2z 319 12 - - HYPH cord-299949-kmn53e2z 319 13 infected infect VBN cord-299949-kmn53e2z 319 14 mice mouse NNS cord-299949-kmn53e2z 319 15 Recruitment recruitment NN cord-299949-kmn53e2z 319 16 kinetics kinetic NNS cord-299949-kmn53e2z 319 17 and and CC cord-299949-kmn53e2z 319 18 composition composition NN cord-299949-kmn53e2z 319 19 of of IN cord-299949-kmn53e2z 319 20 antibody antibody NN cord-299949-kmn53e2z 319 21 - - HYPH cord-299949-kmn53e2z 319 22 secreting secrete VBG cord-299949-kmn53e2z 319 23 cells cell NNS cord-299949-kmn53e2z 319 24 within within IN cord-299949-kmn53e2z 319 25 the the DT cord-299949-kmn53e2z 319 26 central central JJ cord-299949-kmn53e2z 319 27 nervous nervous JJ cord-299949-kmn53e2z 319 28 system system NN cord-299949-kmn53e2z 319 29 following follow VBG cord-299949-kmn53e2z 319 30 viral viral JJ cord-299949-kmn53e2z 319 31 encephalomyelitis encephalomyelitis NN cord-299949-kmn53e2z 319 32 CNS cns NN cord-299949-kmn53e2z 319 33 viral viral JJ cord-299949-kmn53e2z 319 34 infection infection NN cord-299949-kmn53e2z 319 35 diverts divert VBZ cord-299949-kmn53e2z 319 36 homing homing NN cord-299949-kmn53e2z 319 37 of of IN cord-299949-kmn53e2z 319 38 antibody antibody NN cord-299949-kmn53e2z 319 39 - - HYPH cord-299949-kmn53e2z 319 40 secreting secrete VBG cord-299949-kmn53e2z 319 41 cells cell NNS cord-299949-kmn53e2z 319 42 from from IN cord-299949-kmn53e2z 319 43 lymphoid lymphoid JJ cord-299949-kmn53e2z 319 44 organs organ NNS cord-299949-kmn53e2z 319 45 to to IN cord-299949-kmn53e2z 319 46 the the DT cord-299949-kmn53e2z 319 47 CNS CNS NNP cord-299949-kmn53e2z 319 48 Protective protective JJ cord-299949-kmn53e2z 319 49 role role NN cord-299949-kmn53e2z 319 50 of of IN cord-299949-kmn53e2z 319 51 TNF TNF NNP cord-299949-kmn53e2z 319 52 - - : cord-299949-kmn53e2z 319 53 a a DT cord-299949-kmn53e2z 320 1 , , , cord-299949-kmn53e2z 320 2 IL-10 IL-10 NNP cord-299949-kmn53e2z 320 3 and and CC cord-299949-kmn53e2z 320 4 IL-2 IL-2 NNP cord-299949-kmn53e2z 320 5 in in IN cord-299949-kmn53e2z 320 6 mice mouse NNS cord-299949-kmn53e2z 320 7 infected infect VBN cord-299949-kmn53e2z 320 8 with with IN cord-299949-kmn53e2z 320 9 the the DT cord-299949-kmn53e2z 320 10 Oshima Oshima NNP cord-299949-kmn53e2z 320 11 strain strain NN cord-299949-kmn53e2z 320 12 of of IN cord-299949-kmn53e2z 320 13 Tick tick NN cord-299949-kmn53e2z 320 14 - - HYPH cord-299949-kmn53e2z 320 15 borne bear VBN cord-299949-kmn53e2z 320 16 encephalitis encephalitis JJ cord-299949-kmn53e2z 320 17 virus virus NN cord-299949-kmn53e2z 320 18 Virus virus NN cord-299949-kmn53e2z 320 19 specificity specificity NN cord-299949-kmn53e2z 320 20 and and CC cord-299949-kmn53e2z 320 21 isotype isotype JJ cord-299949-kmn53e2z 320 22 expression expression NN cord-299949-kmn53e2z 320 23 of of IN cord-299949-kmn53e2z 320 24 intraparenchymal intraparenchymal JJ cord-299949-kmn53e2z 320 25 antibody antibody NN cord-299949-kmn53e2z 320 26 - - HYPH cord-299949-kmn53e2z 320 27 secreting secrete VBG cord-299949-kmn53e2z 320 28 cells cell NNS cord-299949-kmn53e2z 320 29 during during IN cord-299949-kmn53e2z 320 30 sindbis sindbis NN cord-299949-kmn53e2z 320 31 virus virus NN cord-299949-kmn53e2z 320 32 encephalitis encephalitis RB cord-299949-kmn53e2z 320 33 in in IN cord-299949-kmn53e2z 320 34 mice mouse NNS cord-299949-kmn53e2z 321 1 Long long JJ cord-299949-kmn53e2z 321 2 term term NN cord-299949-kmn53e2z 321 3 intraparenchymal intraparenchymal NNP cord-299949-kmn53e2z 322 1 Ig ig JJ cord-299949-kmn53e2z 322 2 secretion secretion NN cord-299949-kmn53e2z 322 3 after after IN cord-299949-kmn53e2z 322 4 acute acute JJ cord-299949-kmn53e2z 322 5 viral viral JJ cord-299949-kmn53e2z 322 6 encephalitis encephalitis RB cord-299949-kmn53e2z 322 7 in in IN cord-299949-kmn53e2z 322 8 mice mouse NNS cord-299949-kmn53e2z 322 9 Roles role NNS cord-299949-kmn53e2z 322 10 of of IN cord-299949-kmn53e2z 322 11 immunoglobulin immunoglobulin NN cord-299949-kmn53e2z 322 12 valency valency NN cord-299949-kmn53e2z 322 13 and and CC cord-299949-kmn53e2z 322 14 the the DT cord-299949-kmn53e2z 322 15 heavy heavy JJ cord-299949-kmn53e2z 322 16 - - HYPH cord-299949-kmn53e2z 322 17 chain chain NN cord-299949-kmn53e2z 322 18 constant constant JJ cord-299949-kmn53e2z 322 19 domain domain NN cord-299949-kmn53e2z 322 20 in in IN cord-299949-kmn53e2z 322 21 antibodymediated antibodymediated JJ cord-299949-kmn53e2z 322 22 downregulation downregulation NN cord-299949-kmn53e2z 322 23 of of IN cord-299949-kmn53e2z 322 24 sindbis sindbis NNP cord-299949-kmn53e2z 322 25 virus virus NN cord-299949-kmn53e2z 322 26 replication replication NN cord-299949-kmn53e2z 322 27 in in IN cord-299949-kmn53e2z 322 28 persistently persistently RB cord-299949-kmn53e2z 322 29 infected infect VBN cord-299949-kmn53e2z 322 30 neurons neuron NNS cord-299949-kmn53e2z 322 31 Memory Memory NNP cord-299949-kmn53e2z 322 32 T T NNP cord-299949-kmn53e2z 322 33 cells cell NNS cord-299949-kmn53e2z 322 34 persisting persist VBG cord-299949-kmn53e2z 322 35 within within IN cord-299949-kmn53e2z 322 36 the the DT cord-299949-kmn53e2z 322 37 brain brain NN cord-299949-kmn53e2z 322 38 after after IN cord-299949-kmn53e2z 322 39 local local JJ cord-299949-kmn53e2z 322 40 infection infection NN cord-299949-kmn53e2z 322 41 show show VBP cord-299949-kmn53e2z 322 42 functional functional JJ cord-299949-kmn53e2z 322 43 adaptations adaptation NNS cord-299949-kmn53e2z 322 44 to to IN cord-299949-kmn53e2z 322 45 their -PRON- PRP$ cord-299949-kmn53e2z 322 46 tissue tissue NN cord-299949-kmn53e2z 322 47 of of IN cord-299949-kmn53e2z 322 48 residence residence NN cord-299949-kmn53e2z 322 49 CD8 CD8 NNP cord-299949-kmn53e2z 322 50 þ þ NNP cord-299949-kmn53e2z 322 51 T T NNP cord-299949-kmn53e2z 322 52 cells cell NNS cord-299949-kmn53e2z 322 53 mediate mediate VBP cord-299949-kmn53e2z 322 54 recovery recovery NN cord-299949-kmn53e2z 322 55 and and CC cord-299949-kmn53e2z 322 56 immunopathology immunopathology NN cord-299949-kmn53e2z 322 57 in in IN cord-299949-kmn53e2z 322 58 West West NNP cord-299949-kmn53e2z 322 59 Nile Nile NNP cord-299949-kmn53e2z 322 60 virus virus NN cord-299949-kmn53e2z 322 61 encephalitis encephalitis RB cord-299949-kmn53e2z 322 62 Interaction Interaction NNP cord-299949-kmn53e2z 322 63 of of IN cord-299949-kmn53e2z 322 64 T T NNP cord-299949-kmn53e2z 322 65 Lymphocytes lymphocyte NNS cord-299949-kmn53e2z 322 66 with with IN cord-299949-kmn53e2z 322 67 cerebral cerebral JJ cord-299949-kmn53e2z 322 68 endothelial endothelial JJ cord-299949-kmn53e2z 322 69 cells cell NNS cord-299949-kmn53e2z 322 70 in in IN cord-299949-kmn53e2z 322 71 vitro vitro FW cord-299949-kmn53e2z 322 72 Cellular cellular JJ cord-299949-kmn53e2z 322 73 immune immune JJ cord-299949-kmn53e2z 322 74 reactivity reactivity NN cord-299949-kmn53e2z 322 75 within within IN cord-299949-kmn53e2z 322 76 the the DT cord-299949-kmn53e2z 322 77 CNS CNS NNP cord-299949-kmn53e2z 322 78 Intracerebral Intracerebral NNP cord-299949-kmn53e2z 322 79 cytokine cytokine NN cord-299949-kmn53e2z 322 80 mRNA mrna NN cord-299949-kmn53e2z 322 81 expression expression NN cord-299949-kmn53e2z 322 82 during during IN cord-299949-kmn53e2z 322 83 fatal fatal JJ cord-299949-kmn53e2z 322 84 and and CC cord-299949-kmn53e2z 322 85 nonfatal nonfatal JJ cord-299949-kmn53e2z 322 86 alphavirus alphavirus NN cord-299949-kmn53e2z 322 87 encephalitis encephalitis RB cord-299949-kmn53e2z 322 88 suggests suggest VBZ cord-299949-kmn53e2z 322 89 a a DT cord-299949-kmn53e2z 322 90 predominant predominant JJ cord-299949-kmn53e2z 322 91 type type NN cord-299949-kmn53e2z 322 92 2 2 CD cord-299949-kmn53e2z 322 93 T t NN cord-299949-kmn53e2z 322 94 cell cell NN cord-299949-kmn53e2z 322 95 response response NN cord-299949-kmn53e2z 322 96 IFN IFN NNP cord-299949-kmn53e2z 322 97 - - HYPH cord-299949-kmn53e2z 322 98 g g NNP cord-299949-kmn53e2z 322 99 - - HYPH cord-299949-kmn53e2z 322 100 mediated mediate VBN cord-299949-kmn53e2z 322 101 suppression suppression NN cord-299949-kmn53e2z 322 102 of of IN cord-299949-kmn53e2z 322 103 coronavirus coronavirus NN cord-299949-kmn53e2z 322 104 replication replication NN cord-299949-kmn53e2z 322 105 in in IN cord-299949-kmn53e2z 322 106 glial glial NN cord-299949-kmn53e2z 322 107 - - HYPH cord-299949-kmn53e2z 322 108 committed commit VBN cord-299949-kmn53e2z 322 109 progenitor progenitor NN cord-299949-kmn53e2z 322 110 cells cell NNS cord-299949-kmn53e2z 322 111 Trafficking traffic VBG cord-299949-kmn53e2z 322 112 of of IN cord-299949-kmn53e2z 322 113 immune immune JJ cord-299949-kmn53e2z 322 114 cells cell NNS cord-299949-kmn53e2z 322 115 in in IN cord-299949-kmn53e2z 322 116 the the DT cord-299949-kmn53e2z 322 117 central central JJ cord-299949-kmn53e2z 322 118 nervous nervous JJ cord-299949-kmn53e2z 322 119 system system NN cord-299949-kmn53e2z 323 1 Emerging emerge VBG cord-299949-kmn53e2z 323 2 viral viral JJ cord-299949-kmn53e2z 323 3 infections infection NNS cord-299949-kmn53e2z 323 4 Brain Brain NNP cord-299949-kmn53e2z 323 5 lesions lesion NNS cord-299949-kmn53e2z 323 6 induced induce VBN cord-299949-kmn53e2z 323 7 by by IN cord-299949-kmn53e2z 323 8 experimental experimental JJ cord-299949-kmn53e2z 323 9 intranasal intranasal NN cord-299949-kmn53e2z 323 10 infection infection NN cord-299949-kmn53e2z 323 11 of of IN cord-299949-kmn53e2z 323 12 japanese japanese JJ cord-299949-kmn53e2z 323 13 encephalitis encephalitis NN cord-299949-kmn53e2z 323 14 virus virus NN cord-299949-kmn53e2z 323 15 in in IN cord-299949-kmn53e2z 323 16 piglets piglet NNS cord-299949-kmn53e2z 323 17 Single single JJ cord-299949-kmn53e2z 323 18 - - HYPH cord-299949-kmn53e2z 323 19 cell cell NN cord-299949-kmn53e2z 323 20 phenotyping phenotyping NN cord-299949-kmn53e2z 323 21 within within IN cord-299949-kmn53e2z 323 22 transparent transparent JJ cord-299949-kmn53e2z 323 23 intact intact JJ cord-299949-kmn53e2z 323 24 tissue tissue NN cord-299949-kmn53e2z 323 25 through through IN cord-299949-kmn53e2z 323 26 whole whole JJ cord-299949-kmn53e2z 323 27 - - HYPH cord-299949-kmn53e2z 323 28 body body NN cord-299949-kmn53e2z 323 29 clearing clearing NN cord-299949-kmn53e2z 323 30 CXCR3 CXCR3 NNP cord-299949-kmn53e2z 323 31 mediates mediate VBZ cord-299949-kmn53e2z 323 32 region region NN cord-299949-kmn53e2z 323 33 - - HYPH cord-299949-kmn53e2z 323 34 specific specific JJ cord-299949-kmn53e2z 323 35 antiviral antiviral JJ cord-299949-kmn53e2z 323 36 T t NN cord-299949-kmn53e2z 323 37 cell cell NN cord-299949-kmn53e2z 323 38 trafficking trafficking NN cord-299949-kmn53e2z 323 39 within within IN cord-299949-kmn53e2z 323 40 the the DT cord-299949-kmn53e2z 323 41 central central JJ cord-299949-kmn53e2z 323 42 nervous nervous JJ cord-299949-kmn53e2z 323 43 system system NN cord-299949-kmn53e2z 323 44 during during IN cord-299949-kmn53e2z 323 45 West West NNP cord-299949-kmn53e2z 323 46 Nile Nile NNP cord-299949-kmn53e2z 323 47 virus virus NN cord-299949-kmn53e2z 323 48 encephalitis encephalitis NN cord-299949-kmn53e2z 323 49 Global global JJ cord-299949-kmn53e2z 323 50 gene gene NN cord-299949-kmn53e2z 323 51 expression expression NN cord-299949-kmn53e2z 323 52 changes change NNS cord-299949-kmn53e2z 323 53 in in IN cord-299949-kmn53e2z 323 54 BV2 BV2 NNP cord-299949-kmn53e2z 323 55 microglial microglial JJ cord-299949-kmn53e2z 323 56 cell cell NN cord-299949-kmn53e2z 323 57 line line NN cord-299949-kmn53e2z 323 58 during during IN cord-299949-kmn53e2z 323 59 rabies rabies NN cord-299949-kmn53e2z 323 60 virus virus NN cord-299949-kmn53e2z 323 61 infection infection NN cord-299949-kmn53e2z 324 1 Innate innate JJ cord-299949-kmn53e2z 324 2 immune immune JJ cord-299949-kmn53e2z 324 3 response response NN cord-299949-kmn53e2z 324 4 gene gene NN cord-299949-kmn53e2z 324 5 expression expression NN cord-299949-kmn53e2z 324 6 profiles profile NNS cord-299949-kmn53e2z 324 7 in in IN cord-299949-kmn53e2z 324 8 central central JJ cord-299949-kmn53e2z 324 9 nervous nervous JJ cord-299949-kmn53e2z 324 10 system system NN cord-299949-kmn53e2z 324 11 of of IN cord-299949-kmn53e2z 324 12 mice mouse NNS cord-299949-kmn53e2z 324 13 infected infect VBN cord-299949-kmn53e2z 324 14 with with IN cord-299949-kmn53e2z 324 15 rabies rabie NNS cord-299949-kmn53e2z 324 16 virus virus NN