id	sid	tid	token	lemma	pos
cord-282246-wyanwvxa	1	1	key	key	NN
cord-282246-wyanwvxa	1	2	:	:	:
cord-282246-wyanwvxa	2	1	cord-282246-wyanwvxa	cord-282246-wyanwvxa	CD
cord-282246-wyanwvxa	2	2	authors	author	NNS
cord-282246-wyanwvxa	2	3	:	:	:
cord-282246-wyanwvxa	2	4	Sen	Sen	NNP
cord-282246-wyanwvxa	2	5	,	,	,
cord-282246-wyanwvxa	2	6	Adrish	Adrish	NNP
cord-282246-wyanwvxa	2	7	;	;	:
cord-282246-wyanwvxa	2	8	Ding	Ding	NNP
cord-282246-wyanwvxa	2	9	,	,	,
cord-282246-wyanwvxa	2	10	Siyuan	Siyuan	NNP
cord-282246-wyanwvxa	2	11	;	;	:
cord-282246-wyanwvxa	2	12	Greenberg	Greenberg	NNP
cord-282246-wyanwvxa	2	13	,	,	,
cord-282246-wyanwvxa	2	14	Harry	Harry	NNP
cord-282246-wyanwvxa	2	15	B.	B.	NNP
cord-282246-wyanwvxa	2	16	title	title	NN
cord-282246-wyanwvxa	2	17	:	:	:
cord-282246-wyanwvxa	2	18	Chapter	chapter	NN
cord-282246-wyanwvxa	2	19	40	40	CD
cord-282246-wyanwvxa	3	1	The	the	DT
cord-282246-wyanwvxa	3	2	Role	role	NN
cord-282246-wyanwvxa	3	3	of	of	IN
cord-282246-wyanwvxa	3	4	Innate	Innate	NNP
cord-282246-wyanwvxa	3	5	Immunity	Immunity	NNP
cord-282246-wyanwvxa	3	6	in	in	IN
cord-282246-wyanwvxa	3	7	Regulating	regulate	VBG
cord-282246-wyanwvxa	3	8	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	3	9	Replication	Replication	NNP
cord-282246-wyanwvxa	3	10	,	,	,
cord-282246-wyanwvxa	3	11	Pathogenesis	Pathogenesis	NNP
cord-282246-wyanwvxa	3	12	,	,	,
cord-282246-wyanwvxa	3	13	and	and	CC
cord-282246-wyanwvxa	3	14	Host	Host	NNP
cord-282246-wyanwvxa	3	15	Range	Range	NNP
cord-282246-wyanwvxa	3	16	Restriction	Restriction	NNP
cord-282246-wyanwvxa	3	17	and	and	CC
cord-282246-wyanwvxa	3	18	the	the	DT
cord-282246-wyanwvxa	3	19	Implications	implication	NNS
cord-282246-wyanwvxa	3	20	for	for	IN
cord-282246-wyanwvxa	3	21	Live	live	JJ
cord-282246-wyanwvxa	3	22	Rotaviral	Rotaviral	NNP
cord-282246-wyanwvxa	3	23	Vaccine	Vaccine	NNP
cord-282246-wyanwvxa	3	24	Development	Development	NNP
cord-282246-wyanwvxa	3	25	date	date	NN
cord-282246-wyanwvxa	3	26	:	:	:
cord-282246-wyanwvxa	3	27	2020	2020	CD
cord-282246-wyanwvxa	3	28	-	-	SYM
cord-282246-wyanwvxa	3	29	12	12	CD
cord-282246-wyanwvxa	3	30	-	-	SYM
cord-282246-wyanwvxa	3	31	31	31	CD
cord-282246-wyanwvxa	3	32	journal	journal	NN
cord-282246-wyanwvxa	3	33	:	:	:
cord-282246-wyanwvxa	4	1	Mucosal	Mucosal	NNP
cord-282246-wyanwvxa	4	2	Vaccines	vaccine	NNS
cord-282246-wyanwvxa	4	3	DOI	DOI	NNP
cord-282246-wyanwvxa	4	4	:	:	:
cord-282246-wyanwvxa	4	5	10.1016	10.1016	CD
cord-282246-wyanwvxa	4	6	/	/	SYM
cord-282246-wyanwvxa	4	7	b978	b978	NN
cord-282246-wyanwvxa	4	8	-	-	HYPH
cord-282246-wyanwvxa	4	9	0	0	CD
cord-282246-wyanwvxa	4	10	-	-	HYPH
cord-282246-wyanwvxa	4	11	12	12	CD
cord-282246-wyanwvxa	4	12	-	-	HYPH
cord-282246-wyanwvxa	4	13	811924	811924	CD
cord-282246-wyanwvxa	4	14	-	-	HYPH
cord-282246-wyanwvxa	4	15	2.00041	2.00041	CD
cord-282246-wyanwvxa	4	16	-	-	SYM
cord-282246-wyanwvxa	4	17	9	9	CD
cord-282246-wyanwvxa	4	18	sha	sha	NN
cord-282246-wyanwvxa	4	19	:	:	:
cord-282246-wyanwvxa	5	1	75662e9515101f5b72f81b1bdc2d3917b1338b24	75662e9515101f5b72f81b1bdc2d3917b1338b24	CD
cord-282246-wyanwvxa	5	2	doc_id	doc_id	CD
cord-282246-wyanwvxa	5	3	:	:	:
cord-282246-wyanwvxa	5	4	282246	282246	CD
cord-282246-wyanwvxa	5	5	cord_uid	cord_uid	NNS
cord-282246-wyanwvxa	5	6	:	:	:
cord-282246-wyanwvxa	6	1	wyanwvxa	wyanwvxa	NNP
cord-282246-wyanwvxa	6	2	Abstract	Abstract	NNP
cord-282246-wyanwvxa	6	3	Rotaviruses	Rotaviruses	NNP
cord-282246-wyanwvxa	6	4	(	(	-LRB-
cord-282246-wyanwvxa	6	5	RVs	rv	NNS
cord-282246-wyanwvxa	6	6	)	)	-RRB-
cord-282246-wyanwvxa	6	7	are	be	VBP
cord-282246-wyanwvxa	6	8	important	important	JJ
cord-282246-wyanwvxa	6	9	causative	causative	JJ
cord-282246-wyanwvxa	6	10	agents	agent	NNS
cord-282246-wyanwvxa	6	11	of	of	IN
cord-282246-wyanwvxa	6	12	viral	viral	JJ
cord-282246-wyanwvxa	6	13	gastroenteritis	gastroenteritis	NN
cord-282246-wyanwvxa	6	14	in	in	IN
cord-282246-wyanwvxa	6	15	the	the	DT
cord-282246-wyanwvxa	6	16	young	young	JJ
cord-282246-wyanwvxa	6	17	of	of	IN
cord-282246-wyanwvxa	6	18	most	most	JJS
cord-282246-wyanwvxa	6	19	mammalian	mammalian	JJ
cord-282246-wyanwvxa	6	20	species	specie	NNS
cord-282246-wyanwvxa	6	21	studied	study	VBN
cord-282246-wyanwvxa	6	22	,	,	,
cord-282246-wyanwvxa	6	23	including	include	VBG
cord-282246-wyanwvxa	6	24	humans	human	NNS
cord-282246-wyanwvxa	6	25	,	,	,
cord-282246-wyanwvxa	6	26	in	in	IN
cord-282246-wyanwvxa	6	27	which	which	WDT
cord-282246-wyanwvxa	6	28	they	-PRON-	PRP
cord-282246-wyanwvxa	6	29	are	be	VBP
cord-282246-wyanwvxa	6	30	the	the	DT
cord-282246-wyanwvxa	6	31	most	most	RBS
cord-282246-wyanwvxa	6	32	important	important	JJ
cord-282246-wyanwvxa	6	33	cause	cause	NN
cord-282246-wyanwvxa	6	34	of	of	IN
cord-282246-wyanwvxa	6	35	severe	severe	JJ
cord-282246-wyanwvxa	6	36	gastroenteritis	gastroenteritis	NN
cord-282246-wyanwvxa	6	37	worldwide	worldwide	RB
cord-282246-wyanwvxa	6	38	despite	despite	IN
cord-282246-wyanwvxa	6	39	the	the	DT
cord-282246-wyanwvxa	6	40	availability	availability	NN
cord-282246-wyanwvxa	6	41	of	of	IN
cord-282246-wyanwvxa	6	42	several	several	JJ
cord-282246-wyanwvxa	6	43	safe	safe	JJ
cord-282246-wyanwvxa	6	44	and	and	CC
cord-282246-wyanwvxa	6	45	effective	effective	JJ
cord-282246-wyanwvxa	6	46	vaccines	vaccine	NNS
cord-282246-wyanwvxa	6	47	.	.	.
cord-282246-wyanwvxa	7	1	Replication	replication	NN
cord-282246-wyanwvxa	7	2	of	of	IN
cord-282246-wyanwvxa	7	3	RVs	rv	NNS
cord-282246-wyanwvxa	7	4	is	be	VBZ
cord-282246-wyanwvxa	7	5	restricted	restrict	VBN
cord-282246-wyanwvxa	7	6	in	in	IN
cord-282246-wyanwvxa	7	7	a	a	DT
cord-282246-wyanwvxa	7	8	host	host	NN
cord-282246-wyanwvxa	7	9	species	species	NN
cord-282246-wyanwvxa	7	10	-	-	HYPH
cord-282246-wyanwvxa	7	11	specific	specific	JJ
cord-282246-wyanwvxa	7	12	manner	manner	NN
cord-282246-wyanwvxa	7	13	,	,	,
cord-282246-wyanwvxa	7	14	and	and	CC
cord-282246-wyanwvxa	7	15	this	this	DT
cord-282246-wyanwvxa	7	16	barrier	barrier	NN
cord-282246-wyanwvxa	7	17	is	be	VBZ
cord-282246-wyanwvxa	7	18	determined	determine	VBN
cord-282246-wyanwvxa	7	19	predominantly	predominantly	RB
cord-282246-wyanwvxa	7	20	by	by	IN
cord-282246-wyanwvxa	7	21	the	the	DT
cord-282246-wyanwvxa	7	22	host	host	NN
cord-282246-wyanwvxa	7	23	interferon	interferon	NN
cord-282246-wyanwvxa	7	24	(	(	-LRB-
cord-282246-wyanwvxa	7	25	IFN	IFN	NNP
cord-282246-wyanwvxa	7	26	)	)	-RRB-
cord-282246-wyanwvxa	7	27	signaling	signal	VBG
cord-282246-wyanwvxa	7	28	and	and	CC
cord-282246-wyanwvxa	7	29	the	the	DT
cord-282246-wyanwvxa	7	30	ability	ability	NN
cord-282246-wyanwvxa	7	31	of	of	IN
cord-282246-wyanwvxa	7	32	different	different	JJ
cord-282246-wyanwvxa	7	33	RV	rv	NN
cord-282246-wyanwvxa	7	34	strains	strain	NNS
cord-282246-wyanwvxa	7	35	to	to	TO
cord-282246-wyanwvxa	7	36	successfully	successfully	RB
cord-282246-wyanwvxa	7	37	negate	negate	VB
cord-282246-wyanwvxa	7	38	IFN	IFN	NNP
cord-282246-wyanwvxa	7	39	activation	activation	NN
cord-282246-wyanwvxa	7	40	and	and	CC
cord-282246-wyanwvxa	7	41	amplification	amplification	NN
cord-282246-wyanwvxa	7	42	pathways	pathway	NNS
cord-282246-wyanwvxa	7	43	.	.	.
cord-282246-wyanwvxa	8	1	In	in	IN
cord-282246-wyanwvxa	8	2	addition	addition	NN
cord-282246-wyanwvxa	8	3	,	,	,
cord-282246-wyanwvxa	8	4	viral	viral	JJ
cord-282246-wyanwvxa	8	5	attachment	attachment	NN
cord-282246-wyanwvxa	8	6	to	to	IN
cord-282246-wyanwvxa	8	7	the	the	DT
cord-282246-wyanwvxa	8	8	target	target	NN
cord-282246-wyanwvxa	8	9	intestinal	intestinal	JJ
cord-282246-wyanwvxa	8	10	epithelial	epithelial	JJ
cord-282246-wyanwvxa	8	11	cells	cell	NNS
cord-282246-wyanwvxa	8	12	also	also	RB
cord-282246-wyanwvxa	8	13	regulates	regulate	VBZ
cord-282246-wyanwvxa	8	14	host	host	NN
cord-282246-wyanwvxa	8	15	range	range	NN
cord-282246-wyanwvxa	8	16	restriction	restriction	NN
cord-282246-wyanwvxa	8	17	.	.	.
cord-282246-wyanwvxa	9	1	Several	several	JJ
cord-282246-wyanwvxa	9	2	studies	study	NNS
cord-282246-wyanwvxa	9	3	have	have	VBP
cord-282246-wyanwvxa	9	4	focused	focus	VBN
cord-282246-wyanwvxa	9	5	on	on	IN
cord-282246-wyanwvxa	9	6	the	the	DT
cord-282246-wyanwvxa	9	7	role	role	NN
cord-282246-wyanwvxa	9	8	of	of	IN
cord-282246-wyanwvxa	9	9	the	the	DT
cord-282246-wyanwvxa	9	10	innate	innate	JJ
cord-282246-wyanwvxa	9	11	immune	immune	JJ
cord-282246-wyanwvxa	9	12	response	response	NN
cord-282246-wyanwvxa	9	13	in	in	IN
cord-282246-wyanwvxa	9	14	regulating	regulate	VBG
cord-282246-wyanwvxa	9	15	RV	rv	NN
cord-282246-wyanwvxa	9	16	replication	replication	NN
cord-282246-wyanwvxa	9	17	and	and	CC
cord-282246-wyanwvxa	9	18	pathogenesis	pathogenesis	NN
cord-282246-wyanwvxa	9	19	.	.	.
cord-282246-wyanwvxa	10	1	The	the	DT
cord-282246-wyanwvxa	10	2	knowledge	knowledge	NN
cord-282246-wyanwvxa	10	3	accrued	accrue	VBN
cord-282246-wyanwvxa	10	4	from	from	IN
cord-282246-wyanwvxa	10	5	these	these	DT
cord-282246-wyanwvxa	10	6	efforts	effort	NNS
cord-282246-wyanwvxa	10	7	is	be	VBZ
cord-282246-wyanwvxa	10	8	likely	likely	JJ
cord-282246-wyanwvxa	10	9	to	to	TO
cord-282246-wyanwvxa	10	10	result	result	VB
cord-282246-wyanwvxa	10	11	in	in	IN
cord-282246-wyanwvxa	10	12	rational	rational	JJ
cord-282246-wyanwvxa	10	13	attenuation	attenuation	NN
cord-282246-wyanwvxa	10	14	of	of	IN
cord-282246-wyanwvxa	10	15	RV	RV	NNP
cord-282246-wyanwvxa	10	16	vaccines	vaccine	NNS
cord-282246-wyanwvxa	10	17	to	to	TO
cord-282246-wyanwvxa	10	18	closely	closely	RB
cord-282246-wyanwvxa	10	19	match	match	VB
cord-282246-wyanwvxa	10	20	circulating	circulating	NN
cord-282246-wyanwvxa	10	21	(	(	-LRB-
cord-282246-wyanwvxa	10	22	and	and	CC
cord-282246-wyanwvxa	10	23	host	host	NN
cord-282246-wyanwvxa	10	24	species	specie	NNS
cord-282246-wyanwvxa	10	25	-	-	HYPH
cord-282246-wyanwvxa	10	26	matched	match	VBN
cord-282246-wyanwvxa	10	27	)	)	-RRB-
cord-282246-wyanwvxa	10	28	virus	virus	NN
cord-282246-wyanwvxa	10	29	strains	strain	NNS
cord-282246-wyanwvxa	10	30	.	.	.
cord-282246-wyanwvxa	11	1	In	in	IN
cord-282246-wyanwvxa	11	2	this	this	DT
cord-282246-wyanwvxa	11	3	chapter	chapter	NN
cord-282246-wyanwvxa	11	4	,	,	,
cord-282246-wyanwvxa	11	5	we	-PRON-	PRP
cord-282246-wyanwvxa	11	6	review	review	VBP
cord-282246-wyanwvxa	11	7	prevalent	prevalent	JJ
cord-282246-wyanwvxa	11	8	models	model	NNS
cord-282246-wyanwvxa	11	9	of	of	IN
cord-282246-wyanwvxa	11	10	RV	RV	NNP
cord-282246-wyanwvxa	11	11	interactions	interaction	NNS
cord-282246-wyanwvxa	11	12	with	with	IN
cord-282246-wyanwvxa	11	13	innate	innate	JJ
cord-282246-wyanwvxa	11	14	immune	immune	JJ
cord-282246-wyanwvxa	11	15	factors	factor	NNS
cord-282246-wyanwvxa	11	16	,	,	,
cord-282246-wyanwvxa	11	17	viral	viral	JJ
cord-282246-wyanwvxa	11	18	strategies	strategy	NNS
cord-282246-wyanwvxa	11	19	employed	employ	VBN
cord-282246-wyanwvxa	11	20	to	to	TO
cord-282246-wyanwvxa	11	21	regulate	regulate	VB
cord-282246-wyanwvxa	11	22	their	-PRON-	PRP$
cord-282246-wyanwvxa	11	23	function	function	NN
cord-282246-wyanwvxa	11	24	,	,	,
cord-282246-wyanwvxa	11	25	and	and	CC
cord-282246-wyanwvxa	11	26	the	the	DT
cord-282246-wyanwvxa	11	27	implications	implication	NNS
cord-282246-wyanwvxa	11	28	of	of	IN
cord-282246-wyanwvxa	11	29	these	these	DT
cord-282246-wyanwvxa	11	30	findings	finding	NNS
cord-282246-wyanwvxa	11	31	for	for	IN
cord-282246-wyanwvxa	11	32	improved	improve	VBN
cord-282246-wyanwvxa	11	33	RV	RV	NNP
cord-282246-wyanwvxa	11	34	vaccine	vaccine	NN
cord-282246-wyanwvxa	11	35	development	development	NN
cord-282246-wyanwvxa	11	36	.	.	.
cord-282246-wyanwvxa	12	1	Rotaviruses	Rotaviruses	NNP
cord-282246-wyanwvxa	12	2	(	(	-LRB-
cord-282246-wyanwvxa	12	3	RVs	rv	NNS
cord-282246-wyanwvxa	12	4	)	)	-RRB-
cord-282246-wyanwvxa	12	5	remain	remain	VBP
cord-282246-wyanwvxa	12	6	one	one	CD
cord-282246-wyanwvxa	12	7	of	of	IN
cord-282246-wyanwvxa	12	8	the	the	DT
cord-282246-wyanwvxa	12	9	two	two	CD
cord-282246-wyanwvxa	12	10	most	most	RBS
cord-282246-wyanwvxa	12	11	important	important	JJ
cord-282246-wyanwvxa	12	12	viral	viral	JJ
cord-282246-wyanwvxa	12	13	causes	cause	NNS
cord-282246-wyanwvxa	12	14	of	of	IN
cord-282246-wyanwvxa	12	15	gastroenteritis	gastroenteritis	NN
cord-282246-wyanwvxa	12	16	despite	despite	IN
cord-282246-wyanwvxa	12	17	the	the	DT
cord-282246-wyanwvxa	12	18	availability	availability	NN
cord-282246-wyanwvxa	12	19	of	of	IN
cord-282246-wyanwvxa	12	20	several	several	JJ
cord-282246-wyanwvxa	12	21	safe	safe	JJ
cord-282246-wyanwvxa	12	22	and	and	CC
cord-282246-wyanwvxa	12	23	effective	effective	JJ
cord-282246-wyanwvxa	12	24	live	live	JJ
cord-282246-wyanwvxa	12	25	attenuated	attenuated	JJ
cord-282246-wyanwvxa	12	26	vaccines	vaccine	NNS
cord-282246-wyanwvxa	12	27	[	[	-LRB-
cord-282246-wyanwvxa	12	28	1	1	CD
cord-282246-wyanwvxa	12	29	,	,	,
cord-282246-wyanwvxa	12	30	2	2	CD
cord-282246-wyanwvxa	12	31	]	]	-RRB-
cord-282246-wyanwvxa	12	32	.	.	.
cord-282246-wyanwvxa	13	1	Rotavirus	rotavirus	NN
cord-282246-wyanwvxa	13	2	infection	infection	NN
cord-282246-wyanwvxa	13	3	has	have	VBZ
cord-282246-wyanwvxa	13	4	its	-PRON-	PRP$
cord-282246-wyanwvxa	13	5	biggest	big	JJS
cord-282246-wyanwvxa	13	6	health	health	NN
cord-282246-wyanwvxa	13	7	impact	impact	NN
cord-282246-wyanwvxa	13	8	on	on	IN
cord-282246-wyanwvxa	13	9	children	child	NNS
cord-282246-wyanwvxa	13	10	under	under	IN
cord-282246-wyanwvxa	13	11	the	the	DT
cord-282246-wyanwvxa	13	12	age	age	NN
cord-282246-wyanwvxa	13	13	of	of	IN
cord-282246-wyanwvxa	13	14	3	3	CD
cord-282246-wyanwvxa	13	15	years	year	NNS
cord-282246-wyanwvxa	13	16	,	,	,
cord-282246-wyanwvxa	13	17	in	in	IN
cord-282246-wyanwvxa	13	18	whom	whom	WP
cord-282246-wyanwvxa	13	19	it	-PRON-	PRP
cord-282246-wyanwvxa	13	20	still	still	RB
cord-282246-wyanwvxa	13	21	accounts	account	VBZ
cord-282246-wyanwvxa	13	22	for	for	IN
cord-282246-wyanwvxa	13	23	approximately	approximately	RB
cord-282246-wyanwvxa	13	24	200,000	200,000	CD
cord-282246-wyanwvxa	13	25	deaths	death	NNS
cord-282246-wyanwvxa	13	26	annually	annually	RB
cord-282246-wyanwvxa	13	27	,	,	,
cord-282246-wyanwvxa	13	28	almost	almost	RB
cord-282246-wyanwvxa	13	29	entirely	entirely	RB
cord-282246-wyanwvxa	13	30	in	in	IN
cord-282246-wyanwvxa	13	31	less	less	RBR
cord-282246-wyanwvxa	13	32	-	-	HYPH
cord-282246-wyanwvxa	13	33	developed	develop	VBN
cord-282246-wyanwvxa	13	34	countries	country	NNS
cord-282246-wyanwvxa	13	35	[	[	-LRB-
cord-282246-wyanwvxa	13	36	2	2	CD
cord-282246-wyanwvxa	13	37	]	]	-RRB-
cord-282246-wyanwvxa	13	38	.	.	.
cord-282246-wyanwvxa	14	1	RVs	rv	NNS
cord-282246-wyanwvxa	14	2	can	can	MD
cord-282246-wyanwvxa	14	3	infect	infect	VB
cord-282246-wyanwvxa	14	4	many	many	JJ
cord-282246-wyanwvxa	14	5	cells	cell	NNS
cord-282246-wyanwvxa	14	6	of	of	IN
cord-282246-wyanwvxa	14	7	the	the	DT
cord-282246-wyanwvxa	14	8	nonimmune	nonimmune	JJ
cord-282246-wyanwvxa	14	9	host	host	NN
cord-282246-wyanwvxa	14	10	,	,	,
cord-282246-wyanwvxa	14	11	but	but	CC
cord-282246-wyanwvxa	14	12	the	the	DT
cord-282246-wyanwvxa	14	13	overwhelming	overwhelming	JJ
cord-282246-wyanwvxa	14	14	bulk	bulk	NN
cord-282246-wyanwvxa	14	15	of	of	IN
cord-282246-wyanwvxa	14	16	viral	viral	JJ
cord-282246-wyanwvxa	14	17	replication	replication	NN
cord-282246-wyanwvxa	14	18	occurs	occur	VBZ
cord-282246-wyanwvxa	14	19	in	in	IN
cord-282246-wyanwvxa	14	20	the	the	DT
cord-282246-wyanwvxa	14	21	mature	mature	JJ
cord-282246-wyanwvxa	14	22	villus	villus	NN
cord-282246-wyanwvxa	14	23	tip	tip	NN
cord-282246-wyanwvxa	14	24	cells	cell	NNS
cord-282246-wyanwvxa	14	25	of	of	IN
cord-282246-wyanwvxa	14	26	the	the	DT
cord-282246-wyanwvxa	14	27	small	small	JJ
cord-282246-wyanwvxa	14	28	intestine	intestine	NN
cord-282246-wyanwvxa	14	29	[	[	-LRB-
cord-282246-wyanwvxa	14	30	3	3	CD
cord-282246-wyanwvxa	14	31	]	]	-RRB-
cord-282246-wyanwvxa	14	32	.	.	.
cord-282246-wyanwvxa	15	1	In	in	IN
cord-282246-wyanwvxa	15	2	this	this	DT
cord-282246-wyanwvxa	15	3	review	review	NN
cord-282246-wyanwvxa	15	4	,	,	,
cord-282246-wyanwvxa	15	5	we	-PRON-	PRP
cord-282246-wyanwvxa	15	6	focus	focus	VBP
cord-282246-wyanwvxa	15	7	on	on	IN
cord-282246-wyanwvxa	15	8	the	the	DT
cord-282246-wyanwvxa	15	9	regulation	regulation	NN
cord-282246-wyanwvxa	15	10	of	of	IN
cord-282246-wyanwvxa	15	11	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	15	12	replication	replication	NN
cord-282246-wyanwvxa	15	13	by	by	IN
cord-282246-wyanwvxa	15	14	the	the	DT
cord-282246-wyanwvxa	15	15	host	host	NN
cord-282246-wyanwvxa	15	16	innate	innate	JJ
cord-282246-wyanwvxa	15	17	immune	immune	JJ
cord-282246-wyanwvxa	15	18	system	system	NN
cord-282246-wyanwvxa	15	19	,	,	,
cord-282246-wyanwvxa	15	20	the	the	DT
cord-282246-wyanwvxa	15	21	host	host	NN
cord-282246-wyanwvxa	15	22	-	-	HYPH
cord-282246-wyanwvxa	15	23	restricted	restrict	VBN
cord-282246-wyanwvxa	15	24	nature	nature	NN
cord-282246-wyanwvxa	15	25	of	of	IN
cord-282246-wyanwvxa	15	26	the	the	DT
cord-282246-wyanwvxa	15	27	innate	innate	JJ
cord-282246-wyanwvxa	15	28	immune	immune	JJ
cord-282246-wyanwvxa	15	29	response	response	NN
cord-282246-wyanwvxa	15	30	to	to	IN
cord-282246-wyanwvxa	15	31	specific	specific	JJ
cord-282246-wyanwvxa	15	32	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	15	33	strains	strain	NNS
cord-282246-wyanwvxa	15	34	,	,	,
cord-282246-wyanwvxa	15	35	and	and	CC
cord-282246-wyanwvxa	15	36	the	the	DT
cord-282246-wyanwvxa	15	37	practical	practical	JJ
cord-282246-wyanwvxa	15	38	utility	utility	NN
cord-282246-wyanwvxa	15	39	of	of	IN
cord-282246-wyanwvxa	15	40	these	these	DT
cord-282246-wyanwvxa	15	41	host	host	NN
cord-282246-wyanwvxa	15	42	range	range	NN
cord-282246-wyanwvxa	15	43	barriers	barrier	NNS
cord-282246-wyanwvxa	15	44	in	in	IN
cord-282246-wyanwvxa	15	45	the	the	DT
cord-282246-wyanwvxa	15	46	development	development	NN
cord-282246-wyanwvxa	15	47	of	of	IN
cord-282246-wyanwvxa	15	48	safe	safe	JJ
cord-282246-wyanwvxa	15	49	and	and	CC
cord-282246-wyanwvxa	15	50	effective	effective	JJ
cord-282246-wyanwvxa	15	51	RV	RV	NNP
cord-282246-wyanwvxa	15	52	vaccines	vaccine	NNS
cord-282246-wyanwvxa	15	53	.	.	.
cord-282246-wyanwvxa	16	1	Infection	infection	NN
cord-282246-wyanwvxa	16	2	with	with	IN
cord-282246-wyanwvxa	16	3	RV	RV	NNP
cord-282246-wyanwvxa	16	4	results	result	NNS
cord-282246-wyanwvxa	16	5	in	in	IN
cord-282246-wyanwvxa	16	6	the	the	DT
cord-282246-wyanwvxa	16	7	immediate	immediate	JJ
cord-282246-wyanwvxa	16	8	activation	activation	NN
cord-282246-wyanwvxa	16	9	of	of	IN
cord-282246-wyanwvxa	16	10	a	a	DT
cord-282246-wyanwvxa	16	11	conserved	conserved	JJ
cord-282246-wyanwvxa	16	12	cellular	cellular	JJ
cord-282246-wyanwvxa	16	13	innate	innate	JJ
cord-282246-wyanwvxa	16	14	immune	immune	NN
cord-282246-wyanwvxa	16	15	signaling	signal	VBG
cord-282246-wyanwvxa	16	16	pathway	pathway	NN
cord-282246-wyanwvxa	16	17	that	that	WDT
cord-282246-wyanwvxa	16	18	involves	involve	VBZ
cord-282246-wyanwvxa	16	19	multiple	multiple	JJ
cord-282246-wyanwvxa	16	20	pattern	pattern	NN
cord-282246-wyanwvxa	16	21	recognition	recognition	NN
cord-282246-wyanwvxa	16	22	receptors	receptor	NNS
cord-282246-wyanwvxa	16	23	(	(	-LRB-
cord-282246-wyanwvxa	16	24	PRRs	PRRs	NNP
cord-282246-wyanwvxa	16	25	)	)	-RRB-
cord-282246-wyanwvxa	16	26	recognizing	recognize	VBG
cord-282246-wyanwvxa	16	27	discrete	discrete	JJ
cord-282246-wyanwvxa	16	28	RV	rv	NN
cord-282246-wyanwvxa	16	29	-	-	HYPH
cord-282246-wyanwvxa	16	30	encoded	encode	VBN
cord-282246-wyanwvxa	16	31	pathogen	pathogen	NN
cord-282246-wyanwvxa	16	32	-	-	HYPH
cord-282246-wyanwvxa	16	33	associated	associate	VBN
cord-282246-wyanwvxa	16	34	molecular	molecular	JJ
cord-282246-wyanwvxa	16	35	patterns	pattern	NNS
cord-282246-wyanwvxa	16	36	(	(	-LRB-
cord-282246-wyanwvxa	16	37	PAMPs	pamp	NNS
cord-282246-wyanwvxa	16	38	)	)	-RRB-
cord-282246-wyanwvxa	16	39	.	.	.
cord-282246-wyanwvxa	17	1	A	a	DT
cord-282246-wyanwvxa	17	2	primary	primary	JJ
cord-282246-wyanwvxa	17	3	purpose	purpose	NN
cord-282246-wyanwvxa	17	4	of	of	IN
cord-282246-wyanwvxa	17	5	this	this	DT
cord-282246-wyanwvxa	17	6	diverse	diverse	JJ
cord-282246-wyanwvxa	17	7	host	host	NN
cord-282246-wyanwvxa	17	8	-	-	HYPH
cord-282246-wyanwvxa	17	9	signaling	signal	VBG
cord-282246-wyanwvxa	17	10	system	system	NN
cord-282246-wyanwvxa	17	11	is	be	VBZ
cord-282246-wyanwvxa	17	12	to	to	TO
cord-282246-wyanwvxa	17	13	induce	induce	VB
cord-282246-wyanwvxa	17	14	different	different	JJ
cord-282246-wyanwvxa	17	15	types	type	NNS
cord-282246-wyanwvxa	17	16	of	of	IN
cord-282246-wyanwvxa	17	17	interferons	interferon	NNS
cord-282246-wyanwvxa	17	18	(	(	-LRB-
cord-282246-wyanwvxa	17	19	IFNs	IFNs	NNP
cord-282246-wyanwvxa	17	20	)	)	-RRB-
cord-282246-wyanwvxa	17	21	and	and	CC
cord-282246-wyanwvxa	17	22	a	a	DT
cord-282246-wyanwvxa	17	23	set	set	NN
cord-282246-wyanwvxa	17	24	of	of	IN
cord-282246-wyanwvxa	17	25	virus	virus	NN
cord-282246-wyanwvxa	17	26	-	-	HYPH
cord-282246-wyanwvxa	17	27	induced	induce	VBN
cord-282246-wyanwvxa	17	28	stress	stress	NN
cord-282246-wyanwvxa	17	29	genes	gene	NNS
cord-282246-wyanwvxa	17	30	(	(	-LRB-
cord-282246-wyanwvxa	17	31	vISGs	vISGs	NFP
cord-282246-wyanwvxa	17	32	)	)	-RRB-
cord-282246-wyanwvxa	17	33	through	through	IN
cord-282246-wyanwvxa	17	34	two	two	CD
cord-282246-wyanwvxa	17	35	principal	principal	JJ
cord-282246-wyanwvxa	17	36	transcriptional	transcriptional	JJ
cord-282246-wyanwvxa	17	37	factors	factor	NNS
cord-282246-wyanwvxa	17	38	:	:	:
cord-282246-wyanwvxa	17	39	nuclear	nuclear	JJ
cord-282246-wyanwvxa	17	40	factor	factor	NN
cord-282246-wyanwvxa	17	41	-	-	:
cord-282246-wyanwvxa	17	42	κB	κB	NNP
cord-282246-wyanwvxa	17	43	(	(	-LRB-
cord-282246-wyanwvxa	17	44	NF	nf	NN
cord-282246-wyanwvxa	17	45	-	-	HYPH
cord-282246-wyanwvxa	17	46	κB	κB	NNP
cord-282246-wyanwvxa	17	47	)	)	-RRB-
cord-282246-wyanwvxa	17	48	and	and	CC
cord-282246-wyanwvxa	17	49	IFN	IFN	NNP
cord-282246-wyanwvxa	17	50	regulatory	regulatory	JJ
cord-282246-wyanwvxa	17	51	factor	factor	NN
cord-282246-wyanwvxa	17	52	3	3	CD
cord-282246-wyanwvxa	17	53	(	(	-LRB-
cord-282246-wyanwvxa	17	54	IRF3	IRF3	NNP
cord-282246-wyanwvxa	17	55	)	)	-RRB-
cord-282246-wyanwvxa	17	56	[	[	-LRB-
cord-282246-wyanwvxa	17	57	4	4	CD
cord-282246-wyanwvxa	17	58	,	,	,
cord-282246-wyanwvxa	17	59	5	5	CD
cord-282246-wyanwvxa	17	60	]	]	-RRB-
cord-282246-wyanwvxa	17	61	.	.	.
cord-282246-wyanwvxa	18	1	The	the	DT
cord-282246-wyanwvxa	18	2	induced	induced	JJ
cord-282246-wyanwvxa	18	3	IFNs	ifns	NN
cord-282246-wyanwvxa	18	4	and	and	CC
cord-282246-wyanwvxa	18	5	vISGs	visgs	NN
cord-282246-wyanwvxa	18	6	then	then	RB
cord-282246-wyanwvxa	18	7	function	function	VB
cord-282246-wyanwvxa	18	8	to	to	TO
cord-282246-wyanwvxa	18	9	restrict	restrict	VB
cord-282246-wyanwvxa	18	10	RV	rv	NN
cord-282246-wyanwvxa	18	11	replication	replication	NN
cord-282246-wyanwvxa	18	12	and	and	CC
cord-282246-wyanwvxa	18	13	pathogen	pathogen	NN
cord-282246-wyanwvxa	18	14	-	-	HYPH
cord-282246-wyanwvxa	18	15	induced	induce	VBN
cord-282246-wyanwvxa	18	16	cell	cell	NN
cord-282246-wyanwvxa	18	17	injury	injury	NN
cord-282246-wyanwvxa	18	18	[	[	-LRB-
cord-282246-wyanwvxa	18	19	6	6	CD
cord-282246-wyanwvxa	18	20	]	]	-RRB-
cord-282246-wyanwvxa	18	21	.	.	.
cord-282246-wyanwvxa	19	1	Of	of	IN
cord-282246-wyanwvxa	19	2	note	note	NN
cord-282246-wyanwvxa	19	3	,	,	,
cord-282246-wyanwvxa	19	4	RVs	rv	NNS
cord-282246-wyanwvxa	19	5	,	,	,
cord-282246-wyanwvxa	19	6	like	like	IN
cord-282246-wyanwvxa	19	7	virtually	virtually	RB
cord-282246-wyanwvxa	19	8	all	all	DT
cord-282246-wyanwvxa	19	9	other	other	JJ
cord-282246-wyanwvxa	19	10	viral	viral	JJ
cord-282246-wyanwvxa	19	11	pathogens	pathogen	NNS
cord-282246-wyanwvxa	19	12	,	,	,
cord-282246-wyanwvxa	19	13	have	have	VBP
cord-282246-wyanwvxa	19	14	evolved	evolve	VBN
cord-282246-wyanwvxa	19	15	a	a	DT
cord-282246-wyanwvxa	19	16	set	set	NN
cord-282246-wyanwvxa	19	17	of	of	IN
cord-282246-wyanwvxa	19	18	countermeasures	countermeasure	NNS
cord-282246-wyanwvxa	19	19	to	to	TO
cord-282246-wyanwvxa	19	20	inhibit	inhibit	VB
cord-282246-wyanwvxa	19	21	the	the	DT
cord-282246-wyanwvxa	19	22	host	host	NN
cord-282246-wyanwvxa	19	23	innate	innate	JJ
cord-282246-wyanwvxa	19	24	immune	immune	JJ
cord-282246-wyanwvxa	19	25	response	response	NN
cord-282246-wyanwvxa	19	26	,	,	,
cord-282246-wyanwvxa	19	27	and	and	CC
cord-282246-wyanwvxa	19	28	these	these	DT
cord-282246-wyanwvxa	19	29	countermeasures	countermeasure	NNS
cord-282246-wyanwvxa	19	30	are	be	VBP
cord-282246-wyanwvxa	19	31	most	most	RBS
cord-282246-wyanwvxa	19	32	pronounced	pronounce	VBN
cord-282246-wyanwvxa	19	33	during	during	IN
cord-282246-wyanwvxa	19	34	homologous	homologous	JJ
cord-282246-wyanwvxa	19	35	RV	rv	NN
cord-282246-wyanwvxa	19	36	infection	infection	NN
cord-282246-wyanwvxa	19	37	(	(	-LRB-
cord-282246-wyanwvxa	19	38	RV	rv	NN
cord-282246-wyanwvxa	19	39	infection	infection	NN
cord-282246-wyanwvxa	19	40	with	with	IN
cord-282246-wyanwvxa	19	41	a	a	DT
cord-282246-wyanwvxa	19	42	strain	strain	NN
cord-282246-wyanwvxa	19	43	routinely	routinely	RB
cord-282246-wyanwvxa	19	44	isolated	isolate	VBN
cord-282246-wyanwvxa	19	45	from	from	IN
cord-282246-wyanwvxa	19	46	that	that	DT
cord-282246-wyanwvxa	19	47	specific	specific	JJ
cord-282246-wyanwvxa	19	48	host	host	NN
cord-282246-wyanwvxa	19	49	species	specie	NNS
cord-282246-wyanwvxa	19	50	)	)	-RRB-
cord-282246-wyanwvxa	20	1	[	[	-LRB-
cord-282246-wyanwvxa	20	2	7	7	CD
cord-282246-wyanwvxa	20	3	]	]	-RRB-
cord-282246-wyanwvxa	20	4	.	.	.
cord-282246-wyanwvxa	21	1	Interestingly	interestingly	RB
cord-282246-wyanwvxa	21	2	,	,	,
cord-282246-wyanwvxa	21	3	RV	rv	NN
cord-282246-wyanwvxa	21	4	strains	strain	NNS
cord-282246-wyanwvxa	21	5	that	that	WDT
cord-282246-wyanwvxa	21	6	differ	differ	VBP
cord-282246-wyanwvxa	21	7	in	in	IN
cord-282246-wyanwvxa	21	8	their	-PRON-	PRP$
cord-282246-wyanwvxa	21	9	ability	ability	NN
cord-282246-wyanwvxa	21	10	to	to	TO
cord-282246-wyanwvxa	21	11	regulate	regulate	VB
cord-282246-wyanwvxa	21	12	the	the	DT
cord-282246-wyanwvxa	21	13	secretion	secretion	NN
cord-282246-wyanwvxa	21	14	of	of	IN
cord-282246-wyanwvxa	21	15	IFNs	ifn	NNS
cord-282246-wyanwvxa	21	16	similarly	similarly	RB
cord-282246-wyanwvxa	21	17	induce	induce	VBP
cord-282246-wyanwvxa	21	18	this	this	DT
cord-282246-wyanwvxa	21	19	early	early	JJ
cord-282246-wyanwvxa	21	20	recognition	recognition	NN
cord-282246-wyanwvxa	21	21	pathway	pathway	NN
cord-282246-wyanwvxa	21	22	,	,	,
cord-282246-wyanwvxa	21	23	as	as	IN
cord-282246-wyanwvxa	21	24	indicated	indicate	VBN
cord-282246-wyanwvxa	21	25	by	by	IN
cord-282246-wyanwvxa	21	26	the	the	DT
cord-282246-wyanwvxa	21	27	transcriptional	transcriptional	JJ
cord-282246-wyanwvxa	21	28	upregulation	upregulation	NN
cord-282246-wyanwvxa	21	29	of	of	IN
cord-282246-wyanwvxa	21	30	IFNs	ifn	NNS
cord-282246-wyanwvxa	21	31	and	and	CC
cord-282246-wyanwvxa	21	32	several	several	JJ
cord-282246-wyanwvxa	21	33	vISGs	vISGs	.
cord-282246-wyanwvxa	21	34	[	[	-LRB-
cord-282246-wyanwvxa	21	35	8	8	CD
cord-282246-wyanwvxa	21	36	]	]	-RRB-
cord-282246-wyanwvxa	21	37	.	.	.
cord-282246-wyanwvxa	22	1	Based	base	VBN
cord-282246-wyanwvxa	22	2	on	on	IN
cord-282246-wyanwvxa	22	3	the	the	DT
cord-282246-wyanwvxa	22	4	collective	collective	JJ
cord-282246-wyanwvxa	22	5	evidence	evidence	NN
cord-282246-wyanwvxa	22	6	,	,	,
cord-282246-wyanwvxa	22	7	initial	initial	JJ
cord-282246-wyanwvxa	22	8	RV	rv	NN
cord-282246-wyanwvxa	22	9	transcription	transcription	NN
cord-282246-wyanwvxa	22	10	engages	engage	VBZ
cord-282246-wyanwvxa	22	11	the	the	DT
cord-282246-wyanwvxa	22	12	two	two	CD
cord-282246-wyanwvxa	22	13	related	relate	VBN
cord-282246-wyanwvxa	22	14	PRRs	PRRs	NNP
cord-282246-wyanwvxa	22	15	RIG	rig	NN
cord-282246-wyanwvxa	22	16	-	-	:
cord-282246-wyanwvxa	22	17	I	-PRON-	PRP
cord-282246-wyanwvxa	22	18	and	and	CC
cord-282246-wyanwvxa	22	19	MDA-5	MDA-5	NNP
cord-282246-wyanwvxa	23	1	(	(	-LRB-
cord-282246-wyanwvxa	23	2	members	member	NNS
cord-282246-wyanwvxa	23	3	of	of	IN
cord-282246-wyanwvxa	23	4	the	the	DT
cord-282246-wyanwvxa	23	5	family	family	NN
cord-282246-wyanwvxa	23	6	of	of	IN
cord-282246-wyanwvxa	23	7	RIG	rig	NN
cord-282246-wyanwvxa	23	8	-	-	HYPH
cord-282246-wyanwvxa	23	9	I	i	NN
cord-282246-wyanwvxa	23	10	-	-	HYPH
cord-282246-wyanwvxa	23	11	like	like	JJ
cord-282246-wyanwvxa	23	12	receptors	receptor	NNS
cord-282246-wyanwvxa	23	13	,	,	,
cord-282246-wyanwvxa	23	14	or	or	CC
cord-282246-wyanwvxa	23	15	RLRs	rlr	NNS
cord-282246-wyanwvxa	23	16	)	)	-RRB-
cord-282246-wyanwvxa	23	17	[	[	-LRB-
cord-282246-wyanwvxa	23	18	8	8	CD
cord-282246-wyanwvxa	23	19	,	,	,
cord-282246-wyanwvxa	23	20	9	9	CD
cord-282246-wyanwvxa	23	21	]	]	-RRB-
cord-282246-wyanwvxa	23	22	,	,	,
cord-282246-wyanwvxa	23	23	which	which	WDT
cord-282246-wyanwvxa	23	24	then	then	RB
cord-282246-wyanwvxa	23	25	trigger	trigger	VBP
cord-282246-wyanwvxa	23	26	activation	activation	NN
cord-282246-wyanwvxa	23	27	of	of	IN
cord-282246-wyanwvxa	23	28	the	the	DT
cord-282246-wyanwvxa	23	29	mitochondrial	mitochondrial	JJ
cord-282246-wyanwvxa	23	30	antiviral	antiviral	JJ
cord-282246-wyanwvxa	23	31	-	-	HYPH
cord-282246-wyanwvxa	23	32	signaling	signal	VBG
cord-282246-wyanwvxa	23	33	protein	protein	NN
cord-282246-wyanwvxa	23	34	(	(	-LRB-
cord-282246-wyanwvxa	23	35	MAVS	MAVS	NNP
cord-282246-wyanwvxa	23	36	)	)	-RRB-
cord-282246-wyanwvxa	23	37	.	.	.
cord-282246-wyanwvxa	24	1	These	these	DT
cord-282246-wyanwvxa	24	2	receptors	receptor	NNS
cord-282246-wyanwvxa	24	3	are	be	VBP
cord-282246-wyanwvxa	24	4	likely	likely	JJ
cord-282246-wyanwvxa	24	5	to	to	TO
cord-282246-wyanwvxa	24	6	be	be	VB
cord-282246-wyanwvxa	24	7	stimulated	stimulate	VBN
cord-282246-wyanwvxa	24	8	by	by	IN
cord-282246-wyanwvxa	24	9	early	early	JJ
cord-282246-wyanwvxa	24	10	RV	rv	NN
cord-282246-wyanwvxa	24	11	transcriptional	transcriptional	NN
cord-282246-wyanwvxa	24	12	by	by	NN
cord-282246-wyanwvxa	24	13	-	-	HYPH
cord-282246-wyanwvxa	24	14	products	product	NNS
cord-282246-wyanwvxa	24	15	such	such	JJ
cord-282246-wyanwvxa	24	16	as	as	IN
cord-282246-wyanwvxa	24	17	exposed	expose	VBN
cord-282246-wyanwvxa	24	18	5	5	CD
cord-282246-wyanwvxa	24	19	0	0	CD
cord-282246-wyanwvxa	24	20	-phosphate	-phosphate	CD
cord-282246-wyanwvxa	24	21	groups	group	NNS
cord-282246-wyanwvxa	24	22	,	,	,
cord-282246-wyanwvxa	24	23	incompletely	incompletely	RB
cord-282246-wyanwvxa	24	24	methylated	methylate	VBN
cord-282246-wyanwvxa	24	25	5	5	CD
cord-282246-wyanwvxa	24	26	0	0	CD
cord-282246-wyanwvxa	24	27	-cap	-cap	:
cord-282246-wyanwvxa	24	28	structures	structure	NNS
cord-282246-wyanwvxa	24	29	,	,	,
cord-282246-wyanwvxa	24	30	and	and	CC
cord-282246-wyanwvxa	24	31	local	local	JJ
cord-282246-wyanwvxa	24	32	dsRNA	dsrna	NN
cord-282246-wyanwvxa	24	33	structures	structure	NNS
cord-282246-wyanwvxa	24	34	such	such	JJ
cord-282246-wyanwvxa	24	35	as	as	IN
cord-282246-wyanwvxa	24	36	panhandle	panhandle	NN
cord-282246-wyanwvxa	24	37	loops	loop	NNS
cord-282246-wyanwvxa	24	38	in	in	IN
cord-282246-wyanwvxa	24	39	viral	viral	JJ
cord-282246-wyanwvxa	24	40	transcripts	transcript	NNS
cord-282246-wyanwvxa	24	41	[	[	-LRB-
cord-282246-wyanwvxa	24	42	10	10	CD
cord-282246-wyanwvxa	24	43	]	]	-RRB-
cord-282246-wyanwvxa	24	44	.	.	.
cord-282246-wyanwvxa	25	1	In	in	IN
cord-282246-wyanwvxa	25	2	addition	addition	NN
cord-282246-wyanwvxa	25	3	to	to	IN
cord-282246-wyanwvxa	25	4	inducing	induce	VBG
cord-282246-wyanwvxa	25	5	the	the	DT
cord-282246-wyanwvxa	25	6	secretion	secretion	NN
cord-282246-wyanwvxa	25	7	of	of	IN
cord-282246-wyanwvxa	25	8	different	different	JJ
cord-282246-wyanwvxa	25	9	IFNs	ifn	NNS
cord-282246-wyanwvxa	25	10	,	,	,
cord-282246-wyanwvxa	25	11	RLR	RLR	NNP
cord-282246-wyanwvxa	25	12	responses	response	NNS
cord-282246-wyanwvxa	25	13	to	to	IN
cord-282246-wyanwvxa	25	14	RV	RV	NNP
cord-282246-wyanwvxa	25	15	are	be	VBP
cord-282246-wyanwvxa	25	16	likely	likely	JJ
cord-282246-wyanwvxa	25	17	to	to	TO
cord-282246-wyanwvxa	25	18	orchestrate	orchestrate	VB
cord-282246-wyanwvxa	25	19	other	other	JJ
cord-282246-wyanwvxa	25	20	host	host	NN
cord-282246-wyanwvxa	25	21	responses	response	NNS
cord-282246-wyanwvxa	25	22	.	.	.
cord-282246-wyanwvxa	26	1	Rotavirus	rotavirus	NN
cord-282246-wyanwvxa	26	2	activation	activation	NN
cord-282246-wyanwvxa	26	3	of	of	IN
cord-282246-wyanwvxa	26	4	MDA-5	MDA-5	NNP
cord-282246-wyanwvxa	26	5	results	result	NNS
cord-282246-wyanwvxa	26	6	in	in	IN
cord-282246-wyanwvxa	26	7	apoptosis	apoptosis	NN
cord-282246-wyanwvxa	26	8	,	,	,
cord-282246-wyanwvxa	26	9	which	which	WDT
cord-282246-wyanwvxa	26	10	occurs	occur	VBZ
cord-282246-wyanwvxa	26	11	mostly	mostly	RB
cord-282246-wyanwvxa	26	12	in	in	IN
cord-282246-wyanwvxa	26	13	the	the	DT
cord-282246-wyanwvxa	26	14	pancreas	pancreas	NN
cord-282246-wyanwvxa	26	15	of	of	IN
cord-282246-wyanwvxa	26	16	RV	rv	NN
cord-282246-wyanwvxa	26	17	-	-	HYPH
cord-282246-wyanwvxa	26	18	infected	infect	VBN
cord-282246-wyanwvxa	26	19	mice	mouse	NNS
cord-282246-wyanwvxa	26	20	,	,	,
cord-282246-wyanwvxa	26	21	indicating	indicate	VBG
cord-282246-wyanwvxa	26	22	that	that	IN
cord-282246-wyanwvxa	26	23	such	such	JJ
cord-282246-wyanwvxa	26	24	PRRdependent	prrdependent	NN
cord-282246-wyanwvxa	26	25	consequences	consequence	NNS
cord-282246-wyanwvxa	26	26	can	can	MD
cord-282246-wyanwvxa	26	27	occur	occur	VB
cord-282246-wyanwvxa	26	28	in	in	IN
cord-282246-wyanwvxa	26	29	a	a	DT
cord-282246-wyanwvxa	26	30	cell	cell	NN
cord-282246-wyanwvxa	26	31	or	or	CC
cord-282246-wyanwvxa	26	32	organ	organ	NN
cord-282246-wyanwvxa	26	33	type	type	NN
cord-282246-wyanwvxa	26	34	-	-	HYPH
cord-282246-wyanwvxa	26	35	specific	specific	JJ
cord-282246-wyanwvxa	26	36	fashion	fashion	NN
cord-282246-wyanwvxa	26	37	[	[	-LRB-
cord-282246-wyanwvxa	26	38	11	11	CD
cord-282246-wyanwvxa	26	39	]	]	-RRB-
cord-282246-wyanwvxa	27	1	(	(	-LRB-
cord-282246-wyanwvxa	27	2	Chapter	chapter	NN
cord-282246-wyanwvxa	27	3	6	6	CD
cord-282246-wyanwvxa	27	4	:	:	:
cord-282246-wyanwvxa	28	1	Innate	innate	JJ
cord-282246-wyanwvxa	28	2	Immunity	Immunity	NNP
cord-282246-wyanwvxa	28	3	at	at	IN
cord-282246-wyanwvxa	28	4	Mucosal	Mucosal	NNP
cord-282246-wyanwvxa	28	5	Surfaces	Surfaces	NNP
cord-282246-wyanwvxa	28	6	)	)	-RRB-
cord-282246-wyanwvxa	28	7	.	.	.
cord-282246-wyanwvxa	29	1	In	in	IN
cord-282246-wyanwvxa	29	2	addition	addition	NN
cord-282246-wyanwvxa	29	3	to	to	IN
cord-282246-wyanwvxa	29	4	RIG	rig	NN
cord-282246-wyanwvxa	29	5	-	-	HYPH
cord-282246-wyanwvxa	29	6	I	i	NN
cord-282246-wyanwvxa	29	7	-	-	HYPH
cord-282246-wyanwvxa	29	8	and	and	CC
cord-282246-wyanwvxa	29	9	MDA-5-dependent	MDA-5-dependent	NNP
cord-282246-wyanwvxa	29	10	host	host	NN
cord-282246-wyanwvxa	29	11	responses	response	NNS
cord-282246-wyanwvxa	29	12	to	to	IN
cord-282246-wyanwvxa	29	13	RV	RV	NNP
cord-282246-wyanwvxa	29	14	RNA	RNA	NNP
cord-282246-wyanwvxa	29	15	,	,	,
cord-282246-wyanwvxa	29	16	other	other	JJ
cord-282246-wyanwvxa	29	17	sensors	sensor	NNS
cord-282246-wyanwvxa	29	18	are	be	VBP
cord-282246-wyanwvxa	29	19	also	also	RB
cord-282246-wyanwvxa	29	20	recruited	recruit	VBN
cord-282246-wyanwvxa	29	21	by	by	IN
cord-282246-wyanwvxa	29	22	the	the	DT
cord-282246-wyanwvxa	29	23	innate	innate	JJ
cord-282246-wyanwvxa	29	24	immune	immune	JJ
cord-282246-wyanwvxa	29	25	machinery	machinery	NN
cord-282246-wyanwvxa	29	26	to	to	TO
cord-282246-wyanwvxa	29	27	trigger	trigger	VB
cord-282246-wyanwvxa	29	28	early	early	JJ
cord-282246-wyanwvxa	29	29	anti	anti	JJ
cord-282246-wyanwvxa	29	30	-	-	JJ
cord-282246-wyanwvxa	29	31	RV	rv	JJ
cord-282246-wyanwvxa	29	32	responses	response	NNS
cord-282246-wyanwvxa	29	33	.	.	.
cord-282246-wyanwvxa	30	1	Among	among	IN
cord-282246-wyanwvxa	30	2	these	these	DT
cord-282246-wyanwvxa	30	3	is	be	VBZ
cord-282246-wyanwvxa	30	4	a	a	DT
cord-282246-wyanwvxa	30	5	third	third	JJ
cord-282246-wyanwvxa	30	6	member	member	NN
cord-282246-wyanwvxa	30	7	of	of	IN
cord-282246-wyanwvxa	30	8	the	the	DT
cord-282246-wyanwvxa	30	9	RLR	RLR	NNP
cord-282246-wyanwvxa	30	10	family	family	NN
cord-282246-wyanwvxa	30	11	:	:	:
cord-282246-wyanwvxa	30	12	LGP2	LGP2	NNP
cord-282246-wyanwvxa	30	13	,	,	,
cord-282246-wyanwvxa	30	14	which	which	WDT
cord-282246-wyanwvxa	30	15	seems	seem	VBZ
cord-282246-wyanwvxa	30	16	to	to	TO
cord-282246-wyanwvxa	30	17	exert	exert	VB
cord-282246-wyanwvxa	30	18	a	a	DT
cord-282246-wyanwvxa	30	19	proviral	proviral	JJ
cord-282246-wyanwvxa	30	20	effect	effect	NN
cord-282246-wyanwvxa	30	21	on	on	IN
cord-282246-wyanwvxa	30	22	RV	RV	NNP
cord-282246-wyanwvxa	30	23	replication	replication	NN
cord-282246-wyanwvxa	30	24	[	[	-LRB-
cord-282246-wyanwvxa	30	25	9	9	CD
cord-282246-wyanwvxa	30	26	]	]	-RRB-
cord-282246-wyanwvxa	30	27	and	and	CC
cord-282246-wyanwvxa	30	28	whose	whose	WP$
cord-282246-wyanwvxa	30	29	activation	activation	NN
cord-282246-wyanwvxa	30	30	during	during	IN
cord-282246-wyanwvxa	30	31	RV	RV	NNP
cord-282246-wyanwvxa	30	32	infection	infection	NN
cord-282246-wyanwvxa	30	33	may	may	MD
cord-282246-wyanwvxa	30	34	represent	represent	VB
cord-282246-wyanwvxa	30	35	a	a	DT
cord-282246-wyanwvxa	30	36	viral	viral	JJ
cord-282246-wyanwvxa	30	37	strategy	strategy	NN
cord-282246-wyanwvxa	30	38	to	to	TO
cord-282246-wyanwvxa	30	39	dampen	dampen	VB
cord-282246-wyanwvxa	30	40	this	this	DT
cord-282246-wyanwvxa	30	41	pathway	pathway	NN
cord-282246-wyanwvxa	30	42	.	.	.
cord-282246-wyanwvxa	31	1	Yet	yet	RB
cord-282246-wyanwvxa	31	2	another	another	DT
cord-282246-wyanwvxa	31	3	player	player	NN
cord-282246-wyanwvxa	31	4	in	in	IN
cord-282246-wyanwvxa	31	5	the	the	DT
cord-282246-wyanwvxa	31	6	innate	innate	JJ
cord-282246-wyanwvxa	31	7	recognition	recognition	NN
cord-282246-wyanwvxa	31	8	of	of	IN
cord-282246-wyanwvxa	31	9	RV	RV	NNP
cord-282246-wyanwvxa	31	10	is	be	VBZ
cord-282246-wyanwvxa	31	11	the	the	DT
cord-282246-wyanwvxa	31	12	dsRNAdependent	dsrnadependent	JJ
cord-282246-wyanwvxa	31	13	protein	protein	NN
cord-282246-wyanwvxa	31	14	kinase	kinase	VBZ
cord-282246-wyanwvxa	31	15	PKR	PKR	NNP
cord-282246-wyanwvxa	31	16	,	,	,
cord-282246-wyanwvxa	31	17	which	which	WDT
cord-282246-wyanwvxa	31	18	is	be	VBZ
cord-282246-wyanwvxa	31	19	essential	essential	JJ
cord-282246-wyanwvxa	31	20	for	for	IN
cord-282246-wyanwvxa	31	21	RV	rv	NN
cord-282246-wyanwvxa	31	22	-	-	HYPH
cord-282246-wyanwvxa	31	23	infected	infect	VBN
cord-282246-wyanwvxa	31	24	cells	cell	NNS
cord-282246-wyanwvxa	31	25	to	to	TO
cord-282246-wyanwvxa	31	26	secrete	secrete	VB
cord-282246-wyanwvxa	31	27	IFN	IFN	NNP
cord-282246-wyanwvxa	31	28	[	[	-LRB-
cord-282246-wyanwvxa	31	29	8	8	CD
cord-282246-wyanwvxa	31	30	]	]	-RRB-
cord-282246-wyanwvxa	31	31	.	.	.
cord-282246-wyanwvxa	32	1	The	the	DT
cord-282246-wyanwvxa	32	2	molecular	molecular	JJ
cord-282246-wyanwvxa	32	3	basis	basis	NN
cord-282246-wyanwvxa	32	4	for	for	IN
cord-282246-wyanwvxa	32	5	PKR	PKR	NNP
cord-282246-wyanwvxa	32	6	's	's	POS
cord-282246-wyanwvxa	32	7	role	role	NN
cord-282246-wyanwvxa	32	8	during	during	IN
cord-282246-wyanwvxa	32	9	RV	RV	NNP
cord-282246-wyanwvxa	32	10	infection	infection	NN
cord-282246-wyanwvxa	32	11	is	be	VBZ
cord-282246-wyanwvxa	32	12	not	not	RB
cord-282246-wyanwvxa	32	13	well	well	RB
cord-282246-wyanwvxa	32	14	understood	understand	VBN
cord-282246-wyanwvxa	32	15	,	,	,
cord-282246-wyanwvxa	32	16	but	but	CC
cord-282246-wyanwvxa	32	17	given	give	VBN
cord-282246-wyanwvxa	32	18	the	the	DT
cord-282246-wyanwvxa	32	19	importance	importance	NN
cord-282246-wyanwvxa	32	20	of	of	IN
cord-282246-wyanwvxa	32	21	PKR	PKR	NNP
cord-282246-wyanwvxa	32	22	in	in	IN
cord-282246-wyanwvxa	32	23	antiviral	antiviral	JJ
cord-282246-wyanwvxa	32	24	signaling	signaling	NN
cord-282246-wyanwvxa	32	25	in	in	IN
cord-282246-wyanwvxa	32	26	general	general	JJ
cord-282246-wyanwvxa	32	27	and	and	CC
cord-282246-wyanwvxa	32	28	its	-PRON-	PRP$
cord-282246-wyanwvxa	32	29	inhibition	inhibition	NN
cord-282246-wyanwvxa	32	30	by	by	IN
cord-282246-wyanwvxa	32	31	a	a	DT
cord-282246-wyanwvxa	32	32	majority	majority	NN
cord-282246-wyanwvxa	32	33	of	of	IN
cord-282246-wyanwvxa	32	34	viruses	virus	NNS
cord-282246-wyanwvxa	32	35	,	,	,
cord-282246-wyanwvxa	32	36	PKR	PKR	NNP
cord-282246-wyanwvxa	32	37	is	be	VBZ
cord-282246-wyanwvxa	32	38	likely	likely	JJ
cord-282246-wyanwvxa	32	39	to	to	TO
cord-282246-wyanwvxa	32	40	be	be	VB
cord-282246-wyanwvxa	32	41	important	important	JJ
cord-282246-wyanwvxa	32	42	for	for	IN
cord-282246-wyanwvxa	32	43	RV	rv	NN
cord-282246-wyanwvxa	32	44	pathogenicity	pathogenicity	NN
cord-282246-wyanwvxa	32	45	.	.	.
cord-282246-wyanwvxa	33	1	Distinct	distinct	JJ
cord-282246-wyanwvxa	33	2	from	from	IN
cord-282246-wyanwvxa	33	3	the	the	DT
cord-282246-wyanwvxa	33	4	cytosolic	cytosolic	JJ
cord-282246-wyanwvxa	33	5	receptors	receptor	NNS
cord-282246-wyanwvxa	33	6	discussed	discuss	VBN
cord-282246-wyanwvxa	33	7	above	above	RB
cord-282246-wyanwvxa	33	8	,	,	,
cord-282246-wyanwvxa	33	9	RV	RV	NNP
cord-282246-wyanwvxa	33	10	recognition	recognition	NN
cord-282246-wyanwvxa	33	11	also	also	RB
cord-282246-wyanwvxa	33	12	involves	involve	VBZ
cord-282246-wyanwvxa	33	13	the	the	DT
cord-282246-wyanwvxa	33	14	toll	toll	NN
cord-282246-wyanwvxa	33	15	-	-	HYPH
cord-282246-wyanwvxa	33	16	like	like	JJ
cord-282246-wyanwvxa	33	17	receptors	receptor	NNS
cord-282246-wyanwvxa	33	18	(	(	-LRB-
cord-282246-wyanwvxa	33	19	TLRs	TLRs	NNP
cord-282246-wyanwvxa	33	20	)	)	-RRB-
cord-282246-wyanwvxa	33	21	,	,	,
cord-282246-wyanwvxa	33	22	a	a	DT
cord-282246-wyanwvxa	33	23	class	class	NN
cord-282246-wyanwvxa	33	24	of	of	IN
cord-282246-wyanwvxa	33	25	viral	viral	JJ
cord-282246-wyanwvxa	33	26	receptors	receptor	NNS
cord-282246-wyanwvxa	33	27	that	that	WDT
cord-282246-wyanwvxa	33	28	function	function	VBP
cord-282246-wyanwvxa	33	29	in	in	IN
cord-282246-wyanwvxa	33	30	the	the	DT
cord-282246-wyanwvxa	33	31	context	context	NN
cord-282246-wyanwvxa	33	32	of	of	IN
cord-282246-wyanwvxa	33	33	cellular	cellular	JJ
cord-282246-wyanwvxa	33	34	membranes	membrane	NNS
cord-282246-wyanwvxa	33	35	,	,	,
cord-282246-wyanwvxa	33	36	including	include	VBG
cord-282246-wyanwvxa	33	37	surface	surface	NN
cord-282246-wyanwvxa	33	38	and	and	CC
cord-282246-wyanwvxa	33	39	endosomal	endosomal	NNP
cord-282246-wyanwvxa	33	40	membranous	membranous	JJ
cord-282246-wyanwvxa	33	41	components	component	NNS
cord-282246-wyanwvxa	33	42	.	.	.
cord-282246-wyanwvxa	34	1	This	this	DT
cord-282246-wyanwvxa	34	2	aspect	aspect	NN
cord-282246-wyanwvxa	34	3	of	of	IN
cord-282246-wyanwvxa	34	4	innate	innate	JJ
cord-282246-wyanwvxa	34	5	RV	rv	NN
cord-282246-wyanwvxa	34	6	recognition	recognition	NN
cord-282246-wyanwvxa	34	7	possibly	possibly	RB
cord-282246-wyanwvxa	34	8	reflects	reflect	VBZ
cord-282246-wyanwvxa	34	9	the	the	DT
cord-282246-wyanwvxa	34	10	RV	RV	NNP
cord-282246-wyanwvxa	34	11	entry	entry	NN
cord-282246-wyanwvxa	34	12	process	process	NN
cord-282246-wyanwvxa	34	13	that	that	WDT
cord-282246-wyanwvxa	34	14	exploits	exploit	VBZ
cord-282246-wyanwvxa	34	15	endosomal	endosomal	NNP
cord-282246-wyanwvxa	34	16	vesicle	vesicle	NN
cord-282246-wyanwvxa	34	17	transport	transport	NN
cord-282246-wyanwvxa	34	18	to	to	TO
cord-282246-wyanwvxa	34	19	gain	gain	VB
cord-282246-wyanwvxa	34	20	access	access	NN
cord-282246-wyanwvxa	34	21	into	into	IN
cord-282246-wyanwvxa	34	22	host	host	NN
cord-282246-wyanwvxa	34	23	cells	cell	NNS
cord-282246-wyanwvxa	34	24	.	.	.
cord-282246-wyanwvxa	35	1	So	so	RB
cord-282246-wyanwvxa	35	2	far	far	RB
cord-282246-wyanwvxa	35	3	,	,	,
cord-282246-wyanwvxa	35	4	TLR3	TLR3	NNP
cord-282246-wyanwvxa	35	5	,	,	,
cord-282246-wyanwvxa	35	6	TLR7	TLR7	NNP
cord-282246-wyanwvxa	35	7	,	,	,
cord-282246-wyanwvxa	35	8	TLR2	TLR2	NNP
cord-282246-wyanwvxa	35	9	,	,	,
cord-282246-wyanwvxa	35	10	and	and	CC
cord-282246-wyanwvxa	35	11	TLR5	TLR5	NNP
cord-282246-wyanwvxa	35	12	have	have	VBP
cord-282246-wyanwvxa	35	13	all	all	DT
cord-282246-wyanwvxa	35	14	been	be	VBN
cord-282246-wyanwvxa	35	15	implicated	implicate	VBN
cord-282246-wyanwvxa	35	16	as	as	IN
cord-282246-wyanwvxa	35	17	potential	potential	JJ
cord-282246-wyanwvxa	35	18	players	player	NNS
cord-282246-wyanwvxa	35	19	in	in	IN
cord-282246-wyanwvxa	35	20	the	the	DT
cord-282246-wyanwvxa	35	21	innate	innate	JJ
cord-282246-wyanwvxa	35	22	RV	RV	NNP
cord-282246-wyanwvxa	35	23	detection	detection	NN
cord-282246-wyanwvxa	35	24	cascade	cascade	NN
cord-282246-wyanwvxa	35	25	[	[	-LRB-
cord-282246-wyanwvxa	35	26	12À17	12à17	CD
cord-282246-wyanwvxa	35	27	]	]	-RRB-
cord-282246-wyanwvxa	35	28	.	.	.
cord-282246-wyanwvxa	36	1	The	the	DT
cord-282246-wyanwvxa	36	2	ability	ability	NN
cord-282246-wyanwvxa	36	3	of	of	IN
cord-282246-wyanwvxa	36	4	TLR3	TLR3	NNP
cord-282246-wyanwvxa	36	5	to	to	TO
cord-282246-wyanwvxa	36	6	recognize	recognize	VB
cord-282246-wyanwvxa	36	7	and	and	CC
cord-282246-wyanwvxa	36	8	regulate	regulate	VB
cord-282246-wyanwvxa	36	9	RV	RV	NNP
cord-282246-wyanwvxa	36	10	and	and	CC
cord-282246-wyanwvxa	36	11	thus	thus	RB
cord-282246-wyanwvxa	36	12	perpetuate	perpetuate	VB
cord-282246-wyanwvxa	36	13	an	an	DT
cord-282246-wyanwvxa	36	14	antiviral	antiviral	JJ
cord-282246-wyanwvxa	36	15	effect	effect	NN
cord-282246-wyanwvxa	36	16	has	have	VBZ
cord-282246-wyanwvxa	36	17	been	be	VBN
cord-282246-wyanwvxa	36	18	tied	tie	VBN
cord-282246-wyanwvxa	36	19	to	to	IN
cord-282246-wyanwvxa	36	20	TLR3	TLR3	NNP
cord-282246-wyanwvxa	36	21	's	's	POS
cord-282246-wyanwvxa	36	22	agedependent	agedependent	NN
cord-282246-wyanwvxa	36	23	expression	expression	NN
cord-282246-wyanwvxa	36	24	in	in	IN
cord-282246-wyanwvxa	36	25	the	the	DT
cord-282246-wyanwvxa	36	26	intestine	intestine	NN
cord-282246-wyanwvxa	36	27	[	[	-LRB-
cord-282246-wyanwvxa	36	28	18	18	CD
cord-282246-wyanwvxa	36	29	]	]	-RRB-
cord-282246-wyanwvxa	36	30	.	.	.
cord-282246-wyanwvxa	37	1	Since	since	IN
cord-282246-wyanwvxa	37	2	RV	RV	NNP
cord-282246-wyanwvxa	37	3	typically	typically	RB
cord-282246-wyanwvxa	37	4	causes	cause	VBZ
cord-282246-wyanwvxa	37	5	severe	severe	JJ
cord-282246-wyanwvxa	37	6	disease	disease	NN
cord-282246-wyanwvxa	37	7	and	and	CC
cord-282246-wyanwvxa	37	8	replicates	replicate	VBZ
cord-282246-wyanwvxa	37	9	in	in	IN
cord-282246-wyanwvxa	37	10	the	the	DT
cord-282246-wyanwvxa	37	11	intestine	intestine	NN
cord-282246-wyanwvxa	37	12	of	of	IN
cord-282246-wyanwvxa	37	13	infants	infant	NNS
cord-282246-wyanwvxa	37	14	and	and	CC
cord-282246-wyanwvxa	37	15	young	young	JJ
cord-282246-wyanwvxa	37	16	children	child	NNS
cord-282246-wyanwvxa	37	17	(	(	-LRB-
cord-282246-wyanwvxa	37	18	in	in	IN
cord-282246-wyanwvxa	37	19	many	many	JJ
cord-282246-wyanwvxa	37	20	mammalian	mammalian	JJ
cord-282246-wyanwvxa	37	21	species	specie	NNS
cord-282246-wyanwvxa	37	22	)	)	-RRB-
cord-282246-wyanwvxa	37	23	,	,	,
cord-282246-wyanwvxa	37	24	coincidental	coincidental	JJ
cord-282246-wyanwvxa	37	25	with	with	IN
cord-282246-wyanwvxa	37	26	lower	low	JJR
cord-282246-wyanwvxa	37	27	levels	level	NNS
cord-282246-wyanwvxa	37	28	of	of	IN
cord-282246-wyanwvxa	37	29	TLR3	tlr3	CD
cord-282246-wyanwvxa	37	30	expression	expression	NN
cord-282246-wyanwvxa	37	31	in	in	IN
cord-282246-wyanwvxa	37	32	infants	infant	NNS
cord-282246-wyanwvxa	37	33	[	[	-LRB-
cord-282246-wyanwvxa	37	34	18	18	CD
cord-282246-wyanwvxa	37	35	]	]	-RRB-
cord-282246-wyanwvxa	37	36	,	,	,
cord-282246-wyanwvxa	37	37	one	one	CD
cord-282246-wyanwvxa	37	38	possible	possible	JJ
cord-282246-wyanwvxa	37	39	implication	implication	NN
cord-282246-wyanwvxa	37	40	is	be	VBZ
cord-282246-wyanwvxa	37	41	that	that	IN
cord-282246-wyanwvxa	37	42	age	age	NN
cord-282246-wyanwvxa	37	43	-	-	HYPH
cord-282246-wyanwvxa	37	44	restricted	restrict	VBN
cord-282246-wyanwvxa	37	45	RV	rv	NN
cord-282246-wyanwvxa	37	46	intestinal	intestinal	JJ
cord-282246-wyanwvxa	37	47	replication	replication	NN
cord-282246-wyanwvxa	37	48	is	be	VBZ
cord-282246-wyanwvxa	37	49	partly	partly	RB
cord-282246-wyanwvxa	37	50	due	due	JJ
cord-282246-wyanwvxa	37	51	to	to	IN
cord-282246-wyanwvxa	37	52	enhanced	enhance	VBN
cord-282246-wyanwvxa	37	53	TLR3	TLR3	NNP
cord-282246-wyanwvxa	37	54	signaling	signal	VBG
cord-282246-wyanwvxa	37	55	with	with	IN
cord-282246-wyanwvxa	37	56	age	age	NN
cord-282246-wyanwvxa	37	57	in	in	IN
cord-282246-wyanwvxa	37	58	this	this	DT
cord-282246-wyanwvxa	37	59	mucosal	mucosal	JJ
cord-282246-wyanwvxa	37	60	compartment	compartment	NN
cord-282246-wyanwvxa	37	61	.	.	.
cord-282246-wyanwvxa	38	1	Other	other	JJ
cord-282246-wyanwvxa	38	2	TLRs	tlr	NNS
cord-282246-wyanwvxa	38	3	play	play	VBP
cord-282246-wyanwvxa	38	4	specialized	specialize	VBN
cord-282246-wyanwvxa	38	5	roles	role	NNS
cord-282246-wyanwvxa	38	6	in	in	IN
cord-282246-wyanwvxa	38	7	discrete	discrete	JJ
cord-282246-wyanwvxa	38	8	types	type	NNS
cord-282246-wyanwvxa	38	9	of	of	IN
cord-282246-wyanwvxa	38	10	cells	cell	NNS
cord-282246-wyanwvxa	38	11	during	during	IN
cord-282246-wyanwvxa	38	12	RV	RV	NNP
cord-282246-wyanwvxa	38	13	infection	infection	NN
cord-282246-wyanwvxa	38	14	.	.	.
cord-282246-wyanwvxa	39	1	The	the	DT
cord-282246-wyanwvxa	39	2	RVencoded	RVencoded	NNP
cord-282246-wyanwvxa	39	3	enterotoxin	enterotoxin	NNP
cord-282246-wyanwvxa	39	4	NSP4	NSP4	NNP
cord-282246-wyanwvxa	39	5	may	may	MD
cord-282246-wyanwvxa	39	6	function	function	VB
cord-282246-wyanwvxa	39	7	as	as	IN
cord-282246-wyanwvxa	39	8	a	a	DT
cord-282246-wyanwvxa	39	9	PAMP	PAMP	NNP
cord-282246-wyanwvxa	39	10	and	and	CC
cord-282246-wyanwvxa	39	11	in	in	IN
cord-282246-wyanwvxa	39	12	macrophages	macrophage	NNS
cord-282246-wyanwvxa	39	13	triggers	trigger	VBZ
cord-282246-wyanwvxa	39	14	inflammatory	inflammatory	JJ
cord-282246-wyanwvxa	39	15	cytokine	cytokine	JJ
cord-282246-wyanwvxa	39	16	secretion	secretion	NN
cord-282246-wyanwvxa	39	17	by	by	IN
cord-282246-wyanwvxa	39	18	a	a	DT
cord-282246-wyanwvxa	39	19	TLR2-dependent	tlr2-dependent	NN
cord-282246-wyanwvxa	39	20	pathway	pathway	NN
cord-282246-wyanwvxa	39	21	[	[	-LRB-
cord-282246-wyanwvxa	39	22	14	14	CD
cord-282246-wyanwvxa	39	23	]	]	-RRB-
cord-282246-wyanwvxa	39	24	.	.	.
cord-282246-wyanwvxa	40	1	During	during	IN
cord-282246-wyanwvxa	40	2	RV	RV	NNP
cord-282246-wyanwvxa	40	3	infection	infection	NN
cord-282246-wyanwvxa	40	4	in	in	IN
cord-282246-wyanwvxa	40	5	human	human	JJ
cord-282246-wyanwvxa	40	6	enteroid	enteroid	NN
cord-282246-wyanwvxa	40	7	cultures	culture	NNS
cord-282246-wyanwvxa	40	8	[	[	-LRB-
cord-282246-wyanwvxa	40	9	19	19	CD
cord-282246-wyanwvxa	40	10	]	]	-RRB-
cord-282246-wyanwvxa	40	11	and	and	CC
cord-282246-wyanwvxa	40	12	in	in	IN
cord-282246-wyanwvxa	40	13	different	different	JJ
cord-282246-wyanwvxa	40	14	species	specie	NNS
cord-282246-wyanwvxa	40	15	of	of	IN
cord-282246-wyanwvxa	40	16	mammals	mammal	NNS
cord-282246-wyanwvxa	40	17	[	[	-LRB-
cord-282246-wyanwvxa	40	18	20À25	20à25	CD
cord-282246-wyanwvxa	40	19	]	]	-RRB-
cord-282246-wyanwvxa	40	20	,	,	,
cord-282246-wyanwvxa	40	21	different	different	JJ
cord-282246-wyanwvxa	40	22	types	type	NNS
cord-282246-wyanwvxa	40	23	of	of	IN
cord-282246-wyanwvxa	40	24	IFNs	ifn	NNS
cord-282246-wyanwvxa	40	25	are	be	VBP
cord-282246-wyanwvxa	40	26	secreted	secrete	VBN
cord-282246-wyanwvxa	40	27	,	,	,
cord-282246-wyanwvxa	40	28	and	and	CC
cord-282246-wyanwvxa	40	29	as	as	IN
cord-282246-wyanwvxa	40	30	will	will	MD
cord-282246-wyanwvxa	40	31	be	be	VB
cord-282246-wyanwvxa	40	32	discuss	discuss	VB
cord-282246-wyanwvxa	40	33	below	below	RB
cord-282246-wyanwvxa	40	34	,	,	,
cord-282246-wyanwvxa	40	35	antiviral	antiviral	JJ
cord-282246-wyanwvxa	40	36	actions	action	NNS
cord-282246-wyanwvxa	40	37	of	of	IN
cord-282246-wyanwvxa	40	38	these	these	DT
cord-282246-wyanwvxa	40	39	IFNs	ifn	NNS
cord-282246-wyanwvxa	40	40	are	be	VBP
cord-282246-wyanwvxa	40	41	actively	actively	RB
cord-282246-wyanwvxa	40	42	countered	counter	VBN
cord-282246-wyanwvxa	40	43	in	in	IN
cord-282246-wyanwvxa	40	44	a	a	DT
cord-282246-wyanwvxa	40	45	host	host	NN
cord-282246-wyanwvxa	40	46	-	-	HYPH
cord-282246-wyanwvxa	40	47	range	range	NN
cord-282246-wyanwvxa	40	48	-	-	HYPH
cord-282246-wyanwvxa	40	49	specific	specific	JJ
cord-282246-wyanwvxa	40	50	manner	manner	NN
cord-282246-wyanwvxa	40	51	by	by	IN
cord-282246-wyanwvxa	40	52	pathogenic	pathogenic	JJ
cord-282246-wyanwvxa	40	53	RVs	rv	NNS
cord-282246-wyanwvxa	40	54	.	.	.
cord-282246-wyanwvxa	41	1	Of	of	IN
cord-282246-wyanwvxa	41	2	the	the	DT
cord-282246-wyanwvxa	41	3	IFNs	ifns	NN
cord-282246-wyanwvxa	41	4	,	,	,
cord-282246-wyanwvxa	41	5	type	type	NN
cord-282246-wyanwvxa	42	1	I	-PRON-	PRP
cord-282246-wyanwvxa	42	2	IFN	IFN	NNP
cord-282246-wyanwvxa	42	3	is	be	VBZ
cord-282246-wyanwvxa	42	4	mostly	mostly	RB
cord-282246-wyanwvxa	42	5	expressed	express	VBN
cord-282246-wyanwvxa	42	6	in	in	IN
cord-282246-wyanwvxa	42	7	the	the	DT
cord-282246-wyanwvxa	42	8	intestinal	intestinal	JJ
cord-282246-wyanwvxa	42	9	hematopoietic	hematopoietic	JJ
cord-282246-wyanwvxa	42	10	cell	cell	NN
cord-282246-wyanwvxa	42	11	compartment	compartment	NN
cord-282246-wyanwvxa	42	12	rather	rather	RB
cord-282246-wyanwvxa	42	13	than	than	IN
cord-282246-wyanwvxa	42	14	in	in	IN
cord-282246-wyanwvxa	42	15	the	the	DT
cord-282246-wyanwvxa	42	16	epithelium	epithelium	NN
cord-282246-wyanwvxa	42	17	where	where	WRB
cord-282246-wyanwvxa	42	18	RV	RV	NNP
cord-282246-wyanwvxa	42	19	primarily	primarily	RB
cord-282246-wyanwvxa	42	20	replicates	replicate	VBZ
cord-282246-wyanwvxa	42	21	[	[	-LRB-
cord-282246-wyanwvxa	42	22	26	26	CD
cord-282246-wyanwvxa	42	23	]	]	-RRB-
cord-282246-wyanwvxa	42	24	.	.	.
cord-282246-wyanwvxa	43	1	Studies	study	NNS
cord-282246-wyanwvxa	43	2	to	to	IN
cord-282246-wyanwvxa	43	3	date	date	NN
cord-282246-wyanwvxa	43	4	have	have	VBP
cord-282246-wyanwvxa	43	5	implicated	implicate	VBN
cord-282246-wyanwvxa	43	6	TLRdependent	tlrdependent	NN
cord-282246-wyanwvxa	43	7	signaling	signaling	NN
cord-282246-wyanwvxa	43	8	in	in	IN
cord-282246-wyanwvxa	43	9	dendritic	dendritic	JJ
cord-282246-wyanwvxa	43	10	cells	cell	NNS
cord-282246-wyanwvxa	43	11	in	in	IN
cord-282246-wyanwvxa	43	12	the	the	DT
cord-282246-wyanwvxa	43	13	type	type	NN
cord-282246-wyanwvxa	43	14	I	-PRON-	PRP
cord-282246-wyanwvxa	43	15	IFN	IFN	NNP
cord-282246-wyanwvxa	43	16	secretion	secretion	NN
cord-282246-wyanwvxa	43	17	process	process	NN
cord-282246-wyanwvxa	43	18	during	during	IN
cord-282246-wyanwvxa	43	19	RV	rv	NN
cord-282246-wyanwvxa	43	20	infection	infection	NN
cord-282246-wyanwvxa	43	21	[	[	-LRB-
cord-282246-wyanwvxa	43	22	16	16	CD
cord-282246-wyanwvxa	43	23	,	,	,
cord-282246-wyanwvxa	43	24	27	27	CD
cord-282246-wyanwvxa	43	25	,	,	,
cord-282246-wyanwvxa	43	26	28	28	CD
cord-282246-wyanwvxa	43	27	]	]	-RRB-
cord-282246-wyanwvxa	43	28	.	.	.
cord-282246-wyanwvxa	44	1	Infection	infection	NN
cord-282246-wyanwvxa	44	2	of	of	IN
cord-282246-wyanwvxa	44	3	plasmacytoid	plasmacytoid	NN
cord-282246-wyanwvxa	44	4	dendritic	dendritic	JJ
cord-282246-wyanwvxa	44	5	cells	cell	NNS
cord-282246-wyanwvxa	44	6	with	with	IN
cord-282246-wyanwvxa	44	7	RV	RV	NNP
cord-282246-wyanwvxa	44	8	,	,	,
cord-282246-wyanwvxa	44	9	which	which	WDT
cord-282246-wyanwvxa	44	10	are	be	VBP
cord-282246-wyanwvxa	44	11	a	a	DT
cord-282246-wyanwvxa	44	12	major	major	JJ
cord-282246-wyanwvxa	44	13	source	source	NN
cord-282246-wyanwvxa	44	14	of	of	IN
cord-282246-wyanwvxa	44	15	type	type	NN
cord-282246-wyanwvxa	45	1	I	-PRON-	PRP
cord-282246-wyanwvxa	45	2	IFN	IFN	NNP
cord-282246-wyanwvxa	45	3	secretion	secretion	NN
cord-282246-wyanwvxa	45	4	during	during	IN
cord-282246-wyanwvxa	45	5	viral	viral	JJ
cord-282246-wyanwvxa	45	6	infections	infection	NNS
cord-282246-wyanwvxa	45	7	,	,	,
cord-282246-wyanwvxa	45	8	leads	lead	VBZ
cord-282246-wyanwvxa	45	9	to	to	IN
cord-282246-wyanwvxa	45	10	endosome	endosome	NN
cord-282246-wyanwvxa	45	11	-	-	HYPH
cord-282246-wyanwvxa	45	12	dependent	dependent	JJ
cord-282246-wyanwvxa	45	13	(	(	-LRB-
cord-282246-wyanwvxa	45	14	and	and	CC
cord-282246-wyanwvxa	45	15	possibly	possibly	RB
cord-282246-wyanwvxa	45	16	TLR7-mediated	tlr7-mediated	JJ
cord-282246-wyanwvxa	45	17	)	)	-RRB-
cord-282246-wyanwvxa	45	18	type	type	NN
cord-282246-wyanwvxa	45	19	I	-PRON-	PRP
cord-282246-wyanwvxa	45	20	IFN	IFN	NNP
cord-282246-wyanwvxa	45	21	secretion	secretion	NN
cord-282246-wyanwvxa	45	22	that	that	WDT
cord-282246-wyanwvxa	45	23	is	be	VBZ
cord-282246-wyanwvxa	45	24	triggered	trigger	VBN
cord-282246-wyanwvxa	45	25	by	by	IN
cord-282246-wyanwvxa	45	26	viral	viral	JJ
cord-282246-wyanwvxa	45	27	genomic	genomic	NNP
cord-282246-wyanwvxa	45	28	dsRNA	dsRNA	.
cord-282246-wyanwvxa	46	1	(	(	-LRB-
cord-282246-wyanwvxa	46	2	or	or	CC
cord-282246-wyanwvxa	46	3	,	,	,
cord-282246-wyanwvxa	46	4	potentially	potentially	RB
cord-282246-wyanwvxa	46	5	,	,	,
cord-282246-wyanwvxa	46	6	a	a	DT
cord-282246-wyanwvxa	46	7	RV	RV	NNP
cord-282246-wyanwvxa	46	8	structural	structural	JJ
cord-282246-wyanwvxa	46	9	protein	protein	NN
cord-282246-wyanwvxa	46	10	)	)	-RRB-
cord-282246-wyanwvxa	46	11	[	[	-LRB-
cord-282246-wyanwvxa	46	12	13	13	CD
cord-282246-wyanwvxa	46	13	,	,	,
cord-282246-wyanwvxa	46	14	16	16	CD
cord-282246-wyanwvxa	46	15	,	,	,
cord-282246-wyanwvxa	46	16	27	27	CD
cord-282246-wyanwvxa	46	17	,	,	,
cord-282246-wyanwvxa	46	18	28	28	CD
cord-282246-wyanwvxa	46	19	]	]	-RRB-
cord-282246-wyanwvxa	46	20	.	.	.
cord-282246-wyanwvxa	47	1	A	a	DT
cord-282246-wyanwvxa	47	2	central	central	JJ
cord-282246-wyanwvxa	47	3	role	role	NN
cord-282246-wyanwvxa	47	4	for	for	IN
cord-282246-wyanwvxa	47	5	TLR	tlr	NN
cord-282246-wyanwvxa	47	6	-	-	HYPH
cord-282246-wyanwvxa	47	7	dependent	dependent	JJ
cord-282246-wyanwvxa	47	8	defense	defense	NN
cord-282246-wyanwvxa	47	9	against	against	IN
cord-282246-wyanwvxa	47	10	RV	RV	NNP
cord-282246-wyanwvxa	47	11	is	be	VBZ
cord-282246-wyanwvxa	47	12	also	also	RB
cord-282246-wyanwvxa	47	13	indicated	indicate	VBN
cord-282246-wyanwvxa	47	14	by	by	IN
cord-282246-wyanwvxa	47	15	the	the	DT
cord-282246-wyanwvxa	47	16	finding	finding	NN
cord-282246-wyanwvxa	47	17	that	that	IN
cord-282246-wyanwvxa	47	18	the	the	DT
cord-282246-wyanwvxa	47	19	absence	absence	NN
cord-282246-wyanwvxa	47	20	of	of	IN
cord-282246-wyanwvxa	47	21	MyD88	MyD88	NNS
cord-282246-wyanwvxa	47	22	,	,	,
cord-282246-wyanwvxa	47	23	an	an	DT
cord-282246-wyanwvxa	47	24	essential	essential	JJ
cord-282246-wyanwvxa	47	25	convergent	convergent	JJ
cord-282246-wyanwvxa	47	26	adaptor	adaptor	NN
cord-282246-wyanwvxa	47	27	in	in	IN
cord-282246-wyanwvxa	47	28	signaling	signal	VBG
cord-282246-wyanwvxa	47	29	from	from	IN
cord-282246-wyanwvxa	47	30	the	the	DT
cord-282246-wyanwvxa	47	31	different	different	JJ
cord-282246-wyanwvxa	47	32	TLRs	tlr	NNS
cord-282246-wyanwvxa	47	33	,	,	,
cord-282246-wyanwvxa	47	34	results	result	NNS
cord-282246-wyanwvxa	47	35	in	in	IN
cord-282246-wyanwvxa	47	36	increased	increase	VBN
cord-282246-wyanwvxa	47	37	RV	rv	NN
cord-282246-wyanwvxa	47	38	infectivity	infectivity	NN
cord-282246-wyanwvxa	47	39	,	,	,
cord-282246-wyanwvxa	47	40	severity	severity	NN
cord-282246-wyanwvxa	47	41	of	of	IN
cord-282246-wyanwvxa	47	42	diarrhea	diarrhea	NN
cord-282246-wyanwvxa	47	43	,	,	,
cord-282246-wyanwvxa	47	44	and	and	CC
cord-282246-wyanwvxa	47	45	impaired	impair	VBN
cord-282246-wyanwvxa	47	46	humoral	humoral	JJ
cord-282246-wyanwvxa	47	47	immunity	immunity	NN
cord-282246-wyanwvxa	47	48	[	[	-LRB-
cord-282246-wyanwvxa	47	49	12	12	CD
cord-282246-wyanwvxa	47	50	]	]	-RRB-
cord-282246-wyanwvxa	47	51	.	.	.
cord-282246-wyanwvxa	48	1	In	in	IN
cord-282246-wyanwvxa	48	2	addition	addition	NN
cord-282246-wyanwvxa	48	3	,	,	,
cord-282246-wyanwvxa	48	4	RV	RV	NNP
cord-282246-wyanwvxa	48	5	is	be	VBZ
cord-282246-wyanwvxa	48	6	susceptible	susceptible	JJ
cord-282246-wyanwvxa	48	7	to	to	IN
cord-282246-wyanwvxa	48	8	the	the	DT
cord-282246-wyanwvxa	48	9	antiviral	antiviral	JJ
cord-282246-wyanwvxa	48	10	effects	effect	NNS
cord-282246-wyanwvxa	48	11	of	of	IN
cord-282246-wyanwvxa	48	12	TLR5	TLR5	NNP
cord-282246-wyanwvxa	48	13	,	,	,
cord-282246-wyanwvxa	48	14	since	since	IN
cord-282246-wyanwvxa	48	15	activation	activation	NN
cord-282246-wyanwvxa	48	16	of	of	IN
cord-282246-wyanwvxa	48	17	this	this	DT
cord-282246-wyanwvxa	48	18	receptor	receptor	NN
cord-282246-wyanwvxa	48	19	by	by	IN
cord-282246-wyanwvxa	48	20	bacterial	bacterial	JJ
cord-282246-wyanwvxa	48	21	flagellin	flagellin	NN
cord-282246-wyanwvxa	48	22	prevents	prevent	VBZ
cord-282246-wyanwvxa	48	23	or	or	CC
cord-282246-wyanwvxa	48	24	cures	cure	VBZ
cord-282246-wyanwvxa	48	25	RV	rv	NN
cord-282246-wyanwvxa	48	26	infection	infection	NN
cord-282246-wyanwvxa	48	27	by	by	IN
cord-282246-wyanwvxa	48	28	a	a	DT
cord-282246-wyanwvxa	48	29	process	process	NN
cord-282246-wyanwvxa	48	30	that	that	WDT
cord-282246-wyanwvxa	48	31	involves	involve	VBZ
cord-282246-wyanwvxa	48	32	the	the	DT
cord-282246-wyanwvxa	48	33	secretion	secretion	NN
cord-282246-wyanwvxa	48	34	of	of	IN
cord-282246-wyanwvxa	48	35	IL	IL	NNP
cord-282246-wyanwvxa	48	36	22	22	CD
cord-282246-wyanwvxa	48	37	[	[	-LRB-
cord-282246-wyanwvxa	48	38	17	17	CD
cord-282246-wyanwvxa	48	39	,	,	,
cord-282246-wyanwvxa	48	40	29	29	CD
cord-282246-wyanwvxa	48	41	,	,	,
cord-282246-wyanwvxa	48	42	30	30	CD
cord-282246-wyanwvxa	48	43	]	]	-RRB-
cord-282246-wyanwvxa	48	44	.	.	.
cord-282246-wyanwvxa	49	1	Inflammasomes	inflammasome	NNS
cord-282246-wyanwvxa	49	2	are	be	VBP
cord-282246-wyanwvxa	49	3	cytosolic	cytosolic	JJ
cord-282246-wyanwvxa	49	4	multiprotein	multiprotein	NNP
cord-282246-wyanwvxa	49	5	complexes	complex	NNS
cord-282246-wyanwvxa	49	6	that	that	WDT
cord-282246-wyanwvxa	49	7	remain	remain	VBP
cord-282246-wyanwvxa	49	8	quiescent	quiescent	JJ
cord-282246-wyanwvxa	49	9	at	at	IN
cord-282246-wyanwvxa	49	10	resting	rest	VBG
cord-282246-wyanwvxa	49	11	state	state	NN
cord-282246-wyanwvxa	49	12	[	[	-LRB-
cord-282246-wyanwvxa	49	13	31	31	CD
cord-282246-wyanwvxa	49	14	]	]	-RRB-
cord-282246-wyanwvxa	49	15	.	.	.
cord-282246-wyanwvxa	50	1	Upon	upon	IN
cord-282246-wyanwvxa	50	2	activation	activation	NN
cord-282246-wyanwvxa	50	3	,	,	,
cord-282246-wyanwvxa	50	4	apoptosis	apoptosis	NN
cord-282246-wyanwvxa	50	5	-	-	HYPH
cord-282246-wyanwvxa	50	6	associated	associate	VBN
cord-282246-wyanwvxa	50	7	speck	speck	NN
cord-282246-wyanwvxa	50	8	-	-	HYPH
cord-282246-wyanwvxa	50	9	like	like	JJ
cord-282246-wyanwvxa	50	10	protein	protein	NN
cord-282246-wyanwvxa	50	11	containing	contain	VBG
cord-282246-wyanwvxa	50	12	CARD	card	NN
cord-282246-wyanwvxa	50	13	protein	protein	NN
cord-282246-wyanwvxa	50	14	,	,	,
cord-282246-wyanwvxa	50	15	named	name	VBN
cord-282246-wyanwvxa	50	16	ASC	ASC	NNP
cord-282246-wyanwvxa	50	17	(	(	-LRB-
cord-282246-wyanwvxa	50	18	encoded	encode	VBN
cord-282246-wyanwvxa	50	19	by	by	IN
cord-282246-wyanwvxa	50	20	PYCARD	PYCARD	NNP
cord-282246-wyanwvxa	50	21	)	)	-RRB-
cord-282246-wyanwvxa	50	22	and	and	CC
cord-282246-wyanwvxa	50	23	caspase-1	caspase-1	NNP
cord-282246-wyanwvxa	50	24	(	(	-LRB-
cord-282246-wyanwvxa	50	25	encoded	encode	VBN
cord-282246-wyanwvxa	50	26	by	by	IN
cord-282246-wyanwvxa	50	27	CASP1	CASP1	NNP
cord-282246-wyanwvxa	50	28	)	)	-RRB-
cord-282246-wyanwvxa	50	29	,	,	,
cord-282246-wyanwvxa	50	30	oligomerize	oligomerize	NNP
cord-282246-wyanwvxa	50	31	and	and	CC
cord-282246-wyanwvxa	50	32	mediate	mediate	VB
cord-282246-wyanwvxa	50	33	the	the	DT
cord-282246-wyanwvxa	50	34	proteolytic	proteolytic	JJ
cord-282246-wyanwvxa	50	35	processing	processing	NN
cord-282246-wyanwvxa	50	36	of	of	IN
cord-282246-wyanwvxa	50	37	proinflammatory	proinflammatory	JJ
cord-282246-wyanwvxa	50	38	cytokines	cytokine	NNS
cord-282246-wyanwvxa	50	39	such	such	JJ
cord-282246-wyanwvxa	50	40	as	as	IN
cord-282246-wyanwvxa	50	41	pro	pro	JJ
cord-282246-wyanwvxa	50	42	-	-	JJ
cord-282246-wyanwvxa	50	43	IL-1β	il-1β	JJ
cord-282246-wyanwvxa	50	44	and	and	CC
cord-282246-wyanwvxa	50	45	pro	pro	JJ
cord-282246-wyanwvxa	50	46	-	-	:
cord-282246-wyanwvxa	50	47	IL-18	IL-18	NNP
cord-282246-wyanwvxa	50	48	and	and	CC
cord-282246-wyanwvxa	50	49	the	the	DT
cord-282246-wyanwvxa	50	50	pore	pore	NN
cord-282246-wyanwvxa	50	51	-	-	HYPH
cord-282246-wyanwvxa	50	52	forming	form	VBG
cord-282246-wyanwvxa	50	53	protein	protein	NN
cord-282246-wyanwvxa	50	54	gasdermin	gasdermin	NNP
cord-282246-wyanwvxa	50	55	D	D	NNP
cord-282246-wyanwvxa	50	56	,	,	,
cord-282246-wyanwvxa	50	57	ultimately	ultimately	RB
cord-282246-wyanwvxa	50	58	leading	lead	VBG
cord-282246-wyanwvxa	50	59	to	to	IN
cord-282246-wyanwvxa	50	60	a	a	DT
cord-282246-wyanwvxa	50	61	lytic	lytic	JJ
cord-282246-wyanwvxa	50	62	form	form	NN
cord-282246-wyanwvxa	50	63	of	of	IN
cord-282246-wyanwvxa	50	64	cell	cell	NN
cord-282246-wyanwvxa	50	65	death	death	NN
cord-282246-wyanwvxa	50	66	known	know	VBN
cord-282246-wyanwvxa	50	67	as	as	IN
cord-282246-wyanwvxa	50	68	pyroptosis	pyroptosis	NNP
cord-282246-wyanwvxa	50	69	[	[	-LRB-
cord-282246-wyanwvxa	50	70	32	32	CD
cord-282246-wyanwvxa	50	71	]	]	-RRB-
cord-282246-wyanwvxa	50	72	.	.	.
cord-282246-wyanwvxa	51	1	These	these	DT
cord-282246-wyanwvxa	51	2	events	event	NNS
cord-282246-wyanwvxa	51	3	not	not	RB
cord-282246-wyanwvxa	51	4	only	only	RB
cord-282246-wyanwvxa	51	5	contribute	contribute	VBP
cord-282246-wyanwvxa	51	6	to	to	IN
cord-282246-wyanwvxa	51	7	the	the	DT
cord-282246-wyanwvxa	51	8	host	host	NN
cord-282246-wyanwvxa	51	9	defense	defense	NN
cord-282246-wyanwvxa	51	10	against	against	IN
cord-282246-wyanwvxa	51	11	bacterial	bacterial	JJ
cord-282246-wyanwvxa	51	12	and	and	CC
cord-282246-wyanwvxa	51	13	other	other	JJ
cord-282246-wyanwvxa	51	14	microbial	microbial	JJ
cord-282246-wyanwvxa	51	15	infections	infection	NNS
cord-282246-wyanwvxa	51	16	,	,	,
cord-282246-wyanwvxa	51	17	but	but	CC
cord-282246-wyanwvxa	51	18	also	also	RB
cord-282246-wyanwvxa	51	19	regulate	regulate	VBP
cord-282246-wyanwvxa	51	20	the	the	DT
cord-282246-wyanwvxa	51	21	homeostasis	homeostasis	NN
cord-282246-wyanwvxa	51	22	of	of	IN
cord-282246-wyanwvxa	51	23	the	the	DT
cord-282246-wyanwvxa	51	24	immune	immune	JJ
cord-282246-wyanwvxa	51	25	system	system	NN
cord-282246-wyanwvxa	51	26	and	and	CC
cord-282246-wyanwvxa	51	27	the	the	DT
cord-282246-wyanwvxa	51	28	development	development	NN
cord-282246-wyanwvxa	51	29	of	of	IN
cord-282246-wyanwvxa	51	30	various	various	JJ
cord-282246-wyanwvxa	51	31	inflammatory	inflammatory	JJ
cord-282246-wyanwvxa	51	32	diseases	disease	NNS
cord-282246-wyanwvxa	51	33	and	and	CC
cord-282246-wyanwvxa	51	34	cancer	cancer	NN
cord-282246-wyanwvxa	51	35	[	[	-LRB-
cord-282246-wyanwvxa	51	36	33	33	CD
cord-282246-wyanwvxa	51	37	]	]	-RRB-
cord-282246-wyanwvxa	51	38	.	.	.
cord-282246-wyanwvxa	52	1	Although	although	IN
cord-282246-wyanwvxa	52	2	it	-PRON-	PRP
cord-282246-wyanwvxa	52	3	is	be	VBZ
cord-282246-wyanwvxa	52	4	known	know	VBN
cord-282246-wyanwvxa	52	5	that	that	IN
cord-282246-wyanwvxa	52	6	AIM2	AIM2	NNP
cord-282246-wyanwvxa	52	7	and	and	CC
cord-282246-wyanwvxa	52	8	IFI16	IFI16	NNP
cord-282246-wyanwvxa	52	9	inflammasomes	inflammasome	NNS
cord-282246-wyanwvxa	52	10	recognize	recognize	VBP
cord-282246-wyanwvxa	52	11	DNA	dna	NN
cord-282246-wyanwvxa	52	12	viruses	virus	NNS
cord-282246-wyanwvxa	52	13	and	and	CC
cord-282246-wyanwvxa	52	14	that	that	IN
cord-282246-wyanwvxa	52	15	NLRP3	NLRP3	NNP
cord-282246-wyanwvxa	52	16	inflammasome	inflammasome	NNP
cord-282246-wyanwvxa	52	17	responds	respond	VBZ
cord-282246-wyanwvxa	52	18	to	to	IN
cord-282246-wyanwvxa	52	19	general	general	JJ
cord-282246-wyanwvxa	52	20	stress	stress	NN
cord-282246-wyanwvxa	52	21	and	and	CC
cord-282246-wyanwvxa	52	22	breach	breach	NN
cord-282246-wyanwvxa	52	23	of	of	IN
cord-282246-wyanwvxa	52	24	plasma	plasma	NN
cord-282246-wyanwvxa	52	25	/	/	SYM
cord-282246-wyanwvxa	52	26	endosomal	endosomal	NNP
cord-282246-wyanwvxa	52	27	membrane	membrane	NN
cord-282246-wyanwvxa	52	28	integrity	integrity	NN
cord-282246-wyanwvxa	52	29	[	[	-LRB-
cord-282246-wyanwvxa	52	30	34	34	CD
cord-282246-wyanwvxa	52	31	,	,	,
cord-282246-wyanwvxa	52	32	35	35	CD
cord-282246-wyanwvxa	52	33	]	]	-RRB-
cord-282246-wyanwvxa	52	34	,	,	,
cord-282246-wyanwvxa	52	35	how	how	WRB
cord-282246-wyanwvxa	52	36	inflammasomes	inflammasomes	NNP
cord-282246-wyanwvxa	52	37	control	control	NNP
cord-282246-wyanwvxa	52	38	RNA	RNA	NNP
cord-282246-wyanwvxa	52	39	virus	virus	NN
cord-282246-wyanwvxa	52	40	replication	replication	NN
cord-282246-wyanwvxa	52	41	is	be	VBZ
cord-282246-wyanwvxa	52	42	less	less	RBR
cord-282246-wyanwvxa	52	43	well	well	RB
cord-282246-wyanwvxa	52	44	understood	understand	VBN
cord-282246-wyanwvxa	52	45	.	.	.
cord-282246-wyanwvxa	53	1	In	in	IN
cord-282246-wyanwvxa	53	2	addition	addition	NN
cord-282246-wyanwvxa	53	3	,	,	,
cord-282246-wyanwvxa	53	4	whether	whether	IN
cord-282246-wyanwvxa	53	5	noncanonical	noncanonical	JJ
cord-282246-wyanwvxa	53	6	inflammasomes	inflammasome	NNS
cord-282246-wyanwvxa	53	7	operate	operate	VBP
cord-282246-wyanwvxa	53	8	in	in	IN
cord-282246-wyanwvxa	53	9	cell	cell	NN
cord-282246-wyanwvxa	53	10	types	type	NNS
cord-282246-wyanwvxa	53	11	other	other	JJ
cord-282246-wyanwvxa	53	12	than	than	IN
cord-282246-wyanwvxa	53	13	myeloid	myeloid	JJ
cord-282246-wyanwvxa	53	14	cells	cell	NNS
cord-282246-wyanwvxa	53	15	is	be	VBZ
cord-282246-wyanwvxa	53	16	largely	largely	RB
cord-282246-wyanwvxa	53	17	unknown	unknown	JJ
cord-282246-wyanwvxa	53	18	.	.	.
cord-282246-wyanwvxa	54	1	Recently	recently	RB
cord-282246-wyanwvxa	54	2	,	,	,
cord-282246-wyanwvxa	54	3	we	-PRON-	PRP
cord-282246-wyanwvxa	54	4	found	find	VBD
cord-282246-wyanwvxa	54	5	that	that	IN
cord-282246-wyanwvxa	54	6	oral	oral	JJ
cord-282246-wyanwvxa	54	7	infection	infection	NN
cord-282246-wyanwvxa	54	8	of	of	IN
cord-282246-wyanwvxa	54	9	suckling	suckle	VBG
cord-282246-wyanwvxa	54	10	mice	mouse	NNS
cord-282246-wyanwvxa	54	11	with	with	IN
cord-282246-wyanwvxa	54	12	murine	murine	JJ
cord-282246-wyanwvxa	54	13	RV	rv	NN
cord-282246-wyanwvxa	54	14	-	-	HYPH
cord-282246-wyanwvxa	54	15	induced	induce	VBN
cord-282246-wyanwvxa	54	16	robust	robust	JJ
cord-282246-wyanwvxa	54	17	activation	activation	NN
cord-282246-wyanwvxa	54	18	of	of	IN
cord-282246-wyanwvxa	54	19	CASP1	casp1	NN
cord-282246-wyanwvxa	54	20	in	in	IN
cord-282246-wyanwvxa	54	21	the	the	DT
cord-282246-wyanwvxa	54	22	small	small	JJ
cord-282246-wyanwvxa	54	23	intestinal	intestinal	JJ
cord-282246-wyanwvxa	54	24	tissue	tissue	NN
cord-282246-wyanwvxa	54	25	,	,	,
cord-282246-wyanwvxa	54	26	indicating	indicate	VBG
cord-282246-wyanwvxa	54	27	a	a	DT
cord-282246-wyanwvxa	54	28	potential	potential	JJ
cord-282246-wyanwvxa	54	29	role	role	NN
cord-282246-wyanwvxa	54	30	for	for	IN
cord-282246-wyanwvxa	54	31	inflammasomes	inflammasome	NNS
cord-282246-wyanwvxa	54	32	in	in	IN
cord-282246-wyanwvxa	54	33	RV	rv	NN
cord-282246-wyanwvxa	54	34	pathogenesis	pathogenesis	NN
cord-282246-wyanwvxa	54	35	[	[	-LRB-
cord-282246-wyanwvxa	54	36	36	36	CD
cord-282246-wyanwvxa	54	37	]	]	-RRB-
cord-282246-wyanwvxa	54	38	.	.	.
cord-282246-wyanwvxa	55	1	Of	of	IN
cord-282246-wyanwvxa	55	2	note	note	VB
cord-282246-wyanwvxa	55	3	,	,	,
cord-282246-wyanwvxa	55	4	in	in	IN
cord-282246-wyanwvxa	55	5	contrast	contrast	NN
cord-282246-wyanwvxa	55	6	to	to	IN
cord-282246-wyanwvxa	55	7	other	other	JJ
cord-282246-wyanwvxa	55	8	NOD	nod	JJ
cord-282246-wyanwvxa	55	9	-	-	HYPH
cord-282246-wyanwvxa	55	10	like	like	JJ
cord-282246-wyanwvxa	55	11	receptors	receptor	NNS
cord-282246-wyanwvxa	55	12	,	,	,
cord-282246-wyanwvxa	55	13	including	include	VBG
cord-282246-wyanwvxa	55	14	NLRP3	nlrp3	XX
cord-282246-wyanwvxa	55	15	,	,	,
cord-282246-wyanwvxa	55	16	NLRP6	NLRP6	NNP
cord-282246-wyanwvxa	55	17	,	,	,
cord-282246-wyanwvxa	55	18	NLRC4	NLRC4	NNP
cord-282246-wyanwvxa	55	19	,	,	,
cord-282246-wyanwvxa	55	20	and	and	CC
cord-282246-wyanwvxa	55	21	NAIPs	naip	NNS
cord-282246-wyanwvxa	55	22	,	,	,
cord-282246-wyanwvxa	55	23	targeted	target	VBN
cord-282246-wyanwvxa	55	24	deletion	deletion	NN
cord-282246-wyanwvxa	55	25	of	of	IN
cord-282246-wyanwvxa	55	26	NLRP9b	NLRP9b	NNP
cord-282246-wyanwvxa	55	27	in	in	IN
cord-282246-wyanwvxa	55	28	intestinal	intestinal	JJ
cord-282246-wyanwvxa	55	29	epithelial	epithelial	JJ
cord-282246-wyanwvxa	55	30	cells	cell	NNS
cord-282246-wyanwvxa	55	31	(	(	-LRB-
cord-282246-wyanwvxa	55	32	IECs	iec	NNS
cord-282246-wyanwvxa	55	33	)	)	-RRB-
cord-282246-wyanwvxa	55	34	of	of	IN
cord-282246-wyanwvxa	55	35	suckling	suckle	VBG
cord-282246-wyanwvxa	55	36	mice	mouse	NNS
cord-282246-wyanwvxa	55	37	led	lead	VBD
cord-282246-wyanwvxa	55	38	to	to	IN
cord-282246-wyanwvxa	55	39	an	an	DT
cord-282246-wyanwvxa	55	40	increase	increase	NN
cord-282246-wyanwvxa	55	41	in	in	IN
cord-282246-wyanwvxa	55	42	diarrhea	diarrhea	NN
cord-282246-wyanwvxa	55	43	,	,	,
cord-282246-wyanwvxa	55	44	RV	RV	NNP
cord-282246-wyanwvxa	55	45	shedding	shed	VBG
cord-282246-wyanwvxa	55	46	in	in	IN
cord-282246-wyanwvxa	55	47	the	the	DT
cord-282246-wyanwvxa	55	48	feces	fece	NNS
cord-282246-wyanwvxa	55	49	,	,	,
cord-282246-wyanwvxa	55	50	and	and	CC
cord-282246-wyanwvxa	55	51	intraintestinal	intraintestinal	JJ
cord-282246-wyanwvxa	55	52	viral	viral	JJ
cord-282246-wyanwvxa	55	53	replication	replication	NN
cord-282246-wyanwvxa	55	54	compared	compare	VBN
cord-282246-wyanwvxa	55	55	to	to	IN
cord-282246-wyanwvxa	55	56	wild	wild	JJ
cord-282246-wyanwvxa	55	57	-	-	HYPH
cord-282246-wyanwvxa	55	58	type	type	NN
cord-282246-wyanwvxa	55	59	pups	pup	NNS
cord-282246-wyanwvxa	55	60	,	,	,
cord-282246-wyanwvxa	55	61	highlighting	highlight	VBG
cord-282246-wyanwvxa	55	62	a	a	DT
cord-282246-wyanwvxa	55	63	crucial	crucial	JJ
cord-282246-wyanwvxa	55	64	role	role	NN
cord-282246-wyanwvxa	55	65	of	of	IN
cord-282246-wyanwvxa	55	66	NLRP9b	NLRP9b	NNP
cord-282246-wyanwvxa	55	67	in	in	IN
cord-282246-wyanwvxa	55	68	controlling	control	VBG
cord-282246-wyanwvxa	55	69	RV	rv	NN
cord-282246-wyanwvxa	55	70	replication	replication	NN
cord-282246-wyanwvxa	55	71	.	.	.
cord-282246-wyanwvxa	56	1	Mechanistically	Mechanistically	NNP
cord-282246-wyanwvxa	56	2	,	,	,
cord-282246-wyanwvxa	56	3	we	-PRON-	PRP
cord-282246-wyanwvxa	56	4	found	find	VBD
cord-282246-wyanwvxa	56	5	that	that	IN
cord-282246-wyanwvxa	56	6	during	during	IN
cord-282246-wyanwvxa	56	7	RV	RV	NNP
cord-282246-wyanwvxa	56	8	infection	infection	NN
cord-282246-wyanwvxa	56	9	,	,	,
cord-282246-wyanwvxa	56	10	DExH	DExH	NNP
cord-282246-wyanwvxa	56	11	-	-	HYPH
cord-282246-wyanwvxa	56	12	box	box	NN
cord-282246-wyanwvxa	56	13	helicase	helicase	NN
cord-282246-wyanwvxa	56	14	9	9	CD
cord-282246-wyanwvxa	56	15	(	(	-LRB-
cord-282246-wyanwvxa	56	16	DHX9	DHX9	NNP
cord-282246-wyanwvxa	56	17	)	)	-RRB-
cord-282246-wyanwvxa	56	18	binds	bind	VBZ
cord-282246-wyanwvxa	56	19	to	to	IN
cord-282246-wyanwvxa	56	20	viral	viral	JJ
cord-282246-wyanwvxa	56	21	RNA	RNA	NNP
cord-282246-wyanwvxa	56	22	PAMP	PAMP	NNP
cord-282246-wyanwvxa	56	23	and	and	CC
cord-282246-wyanwvxa	56	24	interacts	interact	VBZ
cord-282246-wyanwvxa	56	25	with	with	IN
cord-282246-wyanwvxa	56	26	NLRP9	NLRP9	NNP
cord-282246-wyanwvxa	56	27	to	to	TO
cord-282246-wyanwvxa	56	28	activate	activate	VB
cord-282246-wyanwvxa	56	29	the	the	DT
cord-282246-wyanwvxa	56	30	downstream	downstream	JJ
cord-282246-wyanwvxa	56	31	signaling	signal	VBG
cord-282246-wyanwvxa	56	32	pathway	pathway	NN
cord-282246-wyanwvxa	56	33	(	(	-LRB-
cord-282246-wyanwvxa	56	34	Fig	Fig	NNP
cord-282246-wyanwvxa	56	35	.	.	.
cord-282246-wyanwvxa	56	36	40.1	40.1	CD
cord-282246-wyanwvxa	56	37	)	)	-RRB-
cord-282246-wyanwvxa	56	38	.	.	.
cord-282246-wyanwvxa	57	1	Furthermore	furthermore	RB
cord-282246-wyanwvxa	57	2	,	,	,
cord-282246-wyanwvxa	57	3	primary	primary	JJ
cord-282246-wyanwvxa	57	4	mouse	mouse	NN
cord-282246-wyanwvxa	57	5	intestinal	intestinal	JJ
cord-282246-wyanwvxa	57	6	enteroids	enteroid	NNS
cord-282246-wyanwvxa	57	7	generated	generate	VBN
cord-282246-wyanwvxa	57	8	from	from	IN
cord-282246-wyanwvxa	57	9	DHX9-or	DHX9-or	NNP
cord-282246-wyanwvxa	57	10	NLRP9deficient	NLRP9deficient	NNP
cord-282246-wyanwvxa	57	11	mice	mouse	NNS
cord-282246-wyanwvxa	57	12	produced	produce	VBD
cord-282246-wyanwvxa	57	13	less	less	JJR
cord-282246-wyanwvxa	57	14	IL-18	IL-18	NNP
cord-282246-wyanwvxa	57	15	and	and	CC
cord-282246-wyanwvxa	57	16	underwent	undergo	VBD
cord-282246-wyanwvxa	57	17	less	less	JJR
cord-282246-wyanwvxa	57	18	pyroptosis	pyroptosis	NN
cord-282246-wyanwvxa	57	19	compared	compare	VBN
cord-282246-wyanwvxa	57	20	to	to	IN
cord-282246-wyanwvxa	57	21	wildtype	wildtype	JJ
cord-282246-wyanwvxa	57	22	enteroids	enteroid	NNS
cord-282246-wyanwvxa	57	23	upon	upon	IN
cord-282246-wyanwvxa	57	24	RV	rv	NN
cord-282246-wyanwvxa	57	25	infection	infection	NN
cord-282246-wyanwvxa	57	26	,	,	,
cord-282246-wyanwvxa	57	27	confirming	confirm	VBG
cord-282246-wyanwvxa	57	28	a	a	DT
cord-282246-wyanwvxa	57	29	role	role	NN
cord-282246-wyanwvxa	57	30	for	for	IN
cord-282246-wyanwvxa	57	31	DHX9	DHX9	NNP
cord-282246-wyanwvxa	57	32	in	in	IN
cord-282246-wyanwvxa	57	33	the	the	DT
cord-282246-wyanwvxa	57	34	activation	activation	NN
cord-282246-wyanwvxa	57	35	of	of	IN
cord-282246-wyanwvxa	57	36	the	the	DT
cord-282246-wyanwvxa	57	37	NLRP9b	NLRP9b	NNP
cord-282246-wyanwvxa	57	38	inflammasome	inflammasome	NN
cord-282246-wyanwvxa	57	39	during	during	IN
cord-282246-wyanwvxa	57	40	RV	RV	NNP
cord-282246-wyanwvxa	57	41	infection	infection	NN
cord-282246-wyanwvxa	57	42	[	[	-LRB-
cord-282246-wyanwvxa	57	43	36	36	CD
cord-282246-wyanwvxa	57	44	]	]	-RRB-
cord-282246-wyanwvxa	57	45	.	.	.
cord-282246-wyanwvxa	58	1	Identification	identification	NN
cord-282246-wyanwvxa	58	2	of	of	IN
cord-282246-wyanwvxa	58	3	the	the	DT
cord-282246-wyanwvxa	58	4	DHX9-NLRP9b	DHX9-NLRP9b	NNP
cord-282246-wyanwvxa	58	5	-	-	HYPH
cord-282246-wyanwvxa	58	6	ASC	ASC	NNP
cord-282246-wyanwvxa	58	7	-	-	HYPH
cord-282246-wyanwvxa	58	8	CASP1	casp1	NN
cord-282246-wyanwvxa	58	9	cascade	cascade	NN
cord-282246-wyanwvxa	58	10	as	as	IN
cord-282246-wyanwvxa	58	11	a	a	DT
cord-282246-wyanwvxa	58	12	novel	novel	JJ
cord-282246-wyanwvxa	58	13	RV	rv	NN
cord-282246-wyanwvxa	58	14	-	-	HYPH
cord-282246-wyanwvxa	58	15	sensing	sense	VBG
cord-282246-wyanwvxa	58	16	pathway	pathway	NN
cord-282246-wyanwvxa	58	17	opened	open	VBD
cord-282246-wyanwvxa	58	18	up	up	RP
cord-282246-wyanwvxa	58	19	new	new	JJ
cord-282246-wyanwvxa	58	20	research	research	NN
cord-282246-wyanwvxa	58	21	directions	direction	NNS
cord-282246-wyanwvxa	58	22	.	.	.
cord-282246-wyanwvxa	59	1	Are	be	VBP
cord-282246-wyanwvxa	59	2	there	there	EX
cord-282246-wyanwvxa	59	3	other	other	JJ
cord-282246-wyanwvxa	59	4	inflammasome	inflammasome	NN
cord-282246-wyanwvxa	59	5	sensors	sensor	NNS
cord-282246-wyanwvxa	59	6	of	of	IN
cord-282246-wyanwvxa	59	7	RV	RV	NNP
cord-282246-wyanwvxa	59	8	or	or	CC
cord-282246-wyanwvxa	59	9	other	other	JJ
cord-282246-wyanwvxa	59	10	enteric	enteric	JJ
cord-282246-wyanwvxa	59	11	viruses	virus	NNS
cord-282246-wyanwvxa	59	12	?	?	.
cord-282246-wyanwvxa	60	1	How	how	WRB
cord-282246-wyanwvxa	60	2	do	do	VBP
cord-282246-wyanwvxa	60	3	different	different	JJ
cord-282246-wyanwvxa	60	4	RNAbinding	rnabinding	NN
cord-282246-wyanwvxa	60	5	proteins	protein	NNS
cord-282246-wyanwvxa	60	6	(	(	-LRB-
cord-282246-wyanwvxa	60	7	DHX9	DHX9	NNP
cord-282246-wyanwvxa	60	8	,	,	,
cord-282246-wyanwvxa	60	9	RIG	rig	NN
cord-282246-wyanwvxa	60	10	-	-	:
cord-282246-wyanwvxa	60	11	I	I	NNP
cord-282246-wyanwvxa	60	12	,	,	,
cord-282246-wyanwvxa	60	13	MDA-5	MDA-5	NNP
cord-282246-wyanwvxa	60	14	,	,	,
cord-282246-wyanwvxa	60	15	etc	etc	FW
cord-282246-wyanwvxa	60	16	.	.	.
cord-282246-wyanwvxa	60	17	)	)	-RRB-
cord-282246-wyanwvxa	61	1	coordinate	coordinate	VB
cord-282246-wyanwvxa	61	2	in	in	IN
cord-282246-wyanwvxa	61	3	the	the	DT
cord-282246-wyanwvxa	61	4	cytoplasm	cytoplasm	NN
cord-282246-wyanwvxa	61	5	?	?	.
cord-282246-wyanwvxa	62	1	What	what	WP
cord-282246-wyanwvxa	62	2	is	be	VBZ
cord-282246-wyanwvxa	62	3	the	the	DT
cord-282246-wyanwvxa	62	4	physiological	physiological	JJ
cord-282246-wyanwvxa	62	5	relevance	relevance	NN
cord-282246-wyanwvxa	62	6	of	of	IN
cord-282246-wyanwvxa	62	7	these	these	DT
cord-282246-wyanwvxa	62	8	s	s	NNP
cord-282246-wyanwvxa	62	9	sensors	sensor	NNS
cord-282246-wyanwvxa	62	10	in	in	IN
cord-282246-wyanwvxa	62	11	the	the	DT
cord-282246-wyanwvxa	62	12	human	human	JJ
cord-282246-wyanwvxa	62	13	intestine	intestine	NN
cord-282246-wyanwvxa	62	14	?	?	.
cord-282246-wyanwvxa	63	1	Addressing	address	VBG
cord-282246-wyanwvxa	63	2	these	these	DT
cord-282246-wyanwvxa	63	3	fundamental	fundamental	JJ
cord-282246-wyanwvxa	63	4	issues	issue	NNS
cord-282246-wyanwvxa	63	5	will	will	MD
cord-282246-wyanwvxa	63	6	provide	provide	VB
cord-282246-wyanwvxa	63	7	new	new	JJ
cord-282246-wyanwvxa	63	8	insights	insight	NNS
cord-282246-wyanwvxa	63	9	into	into	IN
cord-282246-wyanwvxa	63	10	the	the	DT
cord-282246-wyanwvxa	63	11	biological	biological	JJ
cord-282246-wyanwvxa	63	12	functions	function	NNS
cord-282246-wyanwvxa	63	13	of	of	IN
cord-282246-wyanwvxa	63	14	host	host	NN
cord-282246-wyanwvxa	63	15	innate	innate	JJ
cord-282246-wyanwvxa	63	16	immune	immune	JJ
cord-282246-wyanwvxa	63	17	recognition	recognition	NN
cord-282246-wyanwvxa	63	18	during	during	IN
cord-282246-wyanwvxa	63	19	acute	acute	JJ
cord-282246-wyanwvxa	63	20	RV	RV	NNP
cord-282246-wyanwvxa	63	21	infection	infection	NN
cord-282246-wyanwvxa	63	22	and	and	CC
cord-282246-wyanwvxa	63	23	,	,	,
cord-282246-wyanwvxa	63	24	more	more	RBR
cord-282246-wyanwvxa	63	25	generally	generally	RB
cord-282246-wyanwvxa	63	26	,	,	,
cord-282246-wyanwvxa	63	27	in	in	IN
cord-282246-wyanwvxa	63	28	overall	overall	JJ
cord-282246-wyanwvxa	63	29	human	human	JJ
cord-282246-wyanwvxa	63	30	enteric	enteric	JJ
cord-282246-wyanwvxa	63	31	health	health	NN
cord-282246-wyanwvxa	63	32	and	and	CC
cord-282246-wyanwvxa	63	33	disease	disease	NN
cord-282246-wyanwvxa	63	34	.	.	.
cord-282246-wyanwvxa	64	1	In	in	IN
cord-282246-wyanwvxa	64	2	addition	addition	NN
cord-282246-wyanwvxa	64	3	,	,	,
cord-282246-wyanwvxa	64	4	answering	answer	VBG
cord-282246-wyanwvxa	64	5	these	these	DT
cord-282246-wyanwvxa	64	6	basic	basic	JJ
cord-282246-wyanwvxa	64	7	questions	question	NNS
cord-282246-wyanwvxa	64	8	is	be	VBZ
cord-282246-wyanwvxa	64	9	likely	likely	JJ
cord-282246-wyanwvxa	64	10	to	to	TO
cord-282246-wyanwvxa	64	11	inform	inform	VB
cord-282246-wyanwvxa	64	12	more	more	RBR
cord-282246-wyanwvxa	64	13	practical	practical	JJ
cord-282246-wyanwvxa	64	14	considerations	consideration	NNS
cord-282246-wyanwvxa	64	15	,	,	,
cord-282246-wyanwvxa	64	16	such	such	JJ
cord-282246-wyanwvxa	64	17	as	as	IN
cord-282246-wyanwvxa	64	18	the	the	DT
cord-282246-wyanwvxa	64	19	development	development	NN
cord-282246-wyanwvxa	64	20	of	of	IN
cord-282246-wyanwvxa	64	21	better	well	JJR
cord-282246-wyanwvxa	64	22	therapeutics	therapeutic	NNS
cord-282246-wyanwvxa	64	23	and	and	CC
cord-282246-wyanwvxa	64	24	preventive	preventive	JJ
cord-282246-wyanwvxa	64	25	strategies	strategy	NNS
cord-282246-wyanwvxa	64	26	for	for	IN
cord-282246-wyanwvxa	64	27	enteric	enteric	JJ
cord-282246-wyanwvxa	64	28	infectious	infectious	JJ
cord-282246-wyanwvxa	64	29	diseases	disease	NNS
cord-282246-wyanwvxa	64	30	.	.	.
cord-282246-wyanwvxa	65	1	The	the	DT
cord-282246-wyanwvxa	65	2	concept	concept	NN
cord-282246-wyanwvxa	65	3	of	of	IN
cord-282246-wyanwvxa	65	4	host	host	NN
cord-282246-wyanwvxa	65	5	range	range	NN
cord-282246-wyanwvxa	65	6	restriction	restriction	NN
cord-282246-wyanwvxa	65	7	(	(	-LRB-
cord-282246-wyanwvxa	65	8	HRR	HRR	NNP
cord-282246-wyanwvxa	65	9	)	)	-RRB-
cord-282246-wyanwvxa	65	10	is	be	VBZ
cord-282246-wyanwvxa	65	11	central	central	JJ
cord-282246-wyanwvxa	65	12	to	to	IN
cord-282246-wyanwvxa	65	13	many	many	JJ
cord-282246-wyanwvxa	65	14	aspects	aspect	NNS
cord-282246-wyanwvxa	65	15	of	of	IN
cord-282246-wyanwvxa	65	16	RV	rv	NN
cord-282246-wyanwvxa	65	17	replication	replication	NN
cord-282246-wyanwvxa	65	18	and	and	CC
cord-282246-wyanwvxa	65	19	disease	disease	NN
cord-282246-wyanwvxa	65	20	,	,	,
cord-282246-wyanwvxa	65	21	including	include	VBG
cord-282246-wyanwvxa	65	22	the	the	DT
cord-282246-wyanwvxa	65	23	development	development	NN
cord-282246-wyanwvxa	65	24	of	of	IN
cord-282246-wyanwvxa	65	25	several	several	JJ
cord-282246-wyanwvxa	65	26	of	of	IN
cord-282246-wyanwvxa	65	27	the	the	DT
cord-282246-wyanwvxa	65	28	currently	currently	RB
cord-282246-wyanwvxa	65	29	available	available	JJ
cord-282246-wyanwvxa	65	30	safe	safe	JJ
cord-282246-wyanwvxa	65	31	and	and	CC
cord-282246-wyanwvxa	65	32	effective	effective	JJ
cord-282246-wyanwvxa	65	33	RV	RV	NNP
cord-282246-wyanwvxa	65	34	vaccines	vaccine	NNS
cord-282246-wyanwvxa	65	35	[	[	-LRB-
cord-282246-wyanwvxa	65	36	37	37	CD
cord-282246-wyanwvxa	65	37	]	]	-RRB-
cord-282246-wyanwvxa	65	38	.	.	.
cord-282246-wyanwvxa	66	1	RVs	rv	NNS
cord-282246-wyanwvxa	66	2	are	be	VBP
cord-282246-wyanwvxa	66	3	distinguished	distinguish	VBN
cord-282246-wyanwvxa	66	4	by	by	IN
cord-282246-wyanwvxa	66	5	being	be	VBG
cord-282246-wyanwvxa	66	6	highly	highly	RB
cord-282246-wyanwvxa	66	7	pathogenic	pathogenic	JJ
cord-282246-wyanwvxa	66	8	and	and	CC
cord-282246-wyanwvxa	66	9	infectious	infectious	JJ
cord-282246-wyanwvxa	66	10	to	to	IN
cord-282246-wyanwvxa	66	11	their	-PRON-	PRP$
cord-282246-wyanwvxa	66	12	homologous	homologous	JJ
cord-282246-wyanwvxa	66	13	host	host	NN
cord-282246-wyanwvxa	66	14	species	specie	NNS
cord-282246-wyanwvxa	66	15	(	(	-LRB-
cord-282246-wyanwvxa	66	16	i.e.	i.e.	FW
cord-282246-wyanwvxa	66	17	,	,	,
cord-282246-wyanwvxa	66	18	the	the	DT
cord-282246-wyanwvxa	66	19	species	specie	NNS
cord-282246-wyanwvxa	66	20	of	of	IN
cord-282246-wyanwvxa	66	21	host	host	NN
cord-282246-wyanwvxa	66	22	normally	normally	RB
cord-282246-wyanwvxa	66	23	infected	infect	VBN
cord-282246-wyanwvxa	66	24	by	by	IN
cord-282246-wyanwvxa	66	25	the	the	DT
cord-282246-wyanwvxa	66	26	particular	particular	JJ
cord-282246-wyanwvxa	66	27	RV	RV	NNP
cord-282246-wyanwvxa	66	28	strain	strain	NN
cord-282246-wyanwvxa	66	29	and	and	CC
cord-282246-wyanwvxa	66	30	the	the	DT
cord-282246-wyanwvxa	66	31	species	specie	NNS
cord-282246-wyanwvxa	66	32	in	in	IN
cord-282246-wyanwvxa	66	33	which	which	WDT
cord-282246-wyanwvxa	66	34	that	that	IN
cord-282246-wyanwvxa	66	35	RV	RV	NNP
cord-282246-wyanwvxa	66	36	strain	strain	NN
cord-282246-wyanwvxa	66	37	spreads	spread	VBZ
cord-282246-wyanwvxa	66	38	efficiently	efficiently	RB
cord-282246-wyanwvxa	66	39	)	)	-RRB-
cord-282246-wyanwvxa	67	1	[	[	-LRB-
cord-282246-wyanwvxa	67	2	38	38	CD
cord-282246-wyanwvxa	67	3	]	]	-RRB-
cord-282246-wyanwvxa	67	4	.	.	.
cord-282246-wyanwvxa	68	1	RVs	rv	NNS
cord-282246-wyanwvxa	68	2	are	be	VBP
cord-282246-wyanwvxa	68	3	also	also	RB
cord-282246-wyanwvxa	68	4	subject	subject	JJ
cord-282246-wyanwvxa	68	5	to	to	IN
cord-282246-wyanwvxa	68	6	very	very	RB
cord-282246-wyanwvxa	68	7	severe	severe	JJ
cord-282246-wyanwvxa	68	8	species	species	NN
cord-282246-wyanwvxa	68	9	-	-	HYPH
cord-282246-wyanwvxa	68	10	specific	specific	JJ
cord-282246-wyanwvxa	68	11	restriction	restriction	NN
cord-282246-wyanwvxa	68	12	of	of	IN
cord-282246-wyanwvxa	68	13	replication	replication	NN
cord-282246-wyanwvxa	68	14	and	and	CC
cord-282246-wyanwvxa	68	15	transmission	transmission	NN
cord-282246-wyanwvxa	68	16	in	in	IN
cord-282246-wyanwvxa	68	17	heterologous	heterologous	JJ
cord-282246-wyanwvxa	68	18	host	host	NN
cord-282246-wyanwvxa	68	19	species	specie	NNS
cord-282246-wyanwvxa	68	20	[	[	-LRB-
cord-282246-wyanwvxa	68	21	39	39	CD
cord-282246-wyanwvxa	68	22	]	]	-RRB-
cord-282246-wyanwvxa	68	23	.	.	.
cord-282246-wyanwvxa	69	1	These	these	DT
cord-282246-wyanwvxa	69	2	fundamental	fundamental	JJ
cord-282246-wyanwvxa	69	3	properties	property	NNS
cord-282246-wyanwvxa	69	4	of	of	IN
cord-282246-wyanwvxa	69	5	RVs	rv	NNS
cord-282246-wyanwvxa	69	6	are	be	VBP
cord-282246-wyanwvxa	69	7	not	not	RB
cord-282246-wyanwvxa	69	8	only	only	RB
cord-282246-wyanwvxa	69	9	of	of	IN
cord-282246-wyanwvxa	69	10	great	great	JJ
cord-282246-wyanwvxa	69	11	importance	importance	NN
cord-282246-wyanwvxa	69	12	for	for	IN
cord-282246-wyanwvxa	69	13	viral	viral	JJ
cord-282246-wyanwvxa	69	14	pathogenicity	pathogenicity	NN
cord-282246-wyanwvxa	69	15	.	.	.
cord-282246-wyanwvxa	70	1	They	-PRON-	PRP
cord-282246-wyanwvxa	70	2	also	also	RB
cord-282246-wyanwvxa	70	3	form	form	VBP
cord-282246-wyanwvxa	70	4	the	the	DT
cord-282246-wyanwvxa	70	5	basis	basis	NN
cord-282246-wyanwvxa	70	6	for	for	IN
cord-282246-wyanwvxa	70	7	several	several	JJ
cord-282246-wyanwvxa	70	8	licensed	license	VBN
cord-282246-wyanwvxa	70	9	live	live	NN
cord-282246-wyanwvxa	70	10	attenuated	attenuate	VBN
cord-282246-wyanwvxa	70	11	orally	orally	RB
cord-282246-wyanwvxa	70	12	administered	administer	VBN
cord-282246-wyanwvxa	70	13	RV	RV	NNP
cord-282246-wyanwvxa	70	14	vaccines	vaccine	NNS
cord-282246-wyanwvxa	70	15	(	(	-LRB-
cord-282246-wyanwvxa	70	16	which	which	WDT
cord-282246-wyanwvxa	70	17	are	be	VBP
cord-282246-wyanwvxa	70	18	attenuated	attenuate	VBN
cord-282246-wyanwvxa	70	19	by	by	IN
cord-282246-wyanwvxa	70	20	virtue	virtue	NN
cord-282246-wyanwvxa	70	21	of	of	IN
cord-282246-wyanwvxa	70	22	their	-PRON-	PRP$
cord-282246-wyanwvxa	70	23	HRR	HRR	NNP
cord-282246-wyanwvxa	70	24	)	)	-RRB-
cord-282246-wyanwvxa	70	25	.	.	.
cord-282246-wyanwvxa	71	1	In	in	IN
cord-282246-wyanwvxa	71	2	traditional	traditional	JJ
cord-282246-wyanwvxa	71	3	continuous	continuous	JJ
cord-282246-wyanwvxa	71	4	cell	cell	NN
cord-282246-wyanwvxa	71	5	line	line	NN
cord-282246-wyanwvxa	71	6	culture	culture	NN
cord-282246-wyanwvxa	71	7	systems	system	NNS
cord-282246-wyanwvxa	71	8	,	,	,
cord-282246-wyanwvxa	71	9	most	most	JJS
cord-282246-wyanwvxa	71	10	RV	rv	NN
cord-282246-wyanwvxa	71	11	strains	strain	NNS
cord-282246-wyanwvxa	71	12	efficiently	efficiently	RB
cord-282246-wyanwvxa	71	13	block	block	VBP
cord-282246-wyanwvxa	71	14	the	the	DT
cord-282246-wyanwvxa	71	15	induction	induction	NN
cord-282246-wyanwvxa	71	16	of	of	IN
cord-282246-wyanwvxa	71	17	type	type	NN
cord-282246-wyanwvxa	72	1	I	-PRON-	PRP
cord-282246-wyanwvxa	72	2	IFN	IFN	NNP
cord-282246-wyanwvxa	72	3	and	and	CC
cord-282246-wyanwvxa	72	4	have	have	VBP
cord-282246-wyanwvxa	72	5	evolved	evolve	VBN
cord-282246-wyanwvxa	72	6	to	to	TO
cord-282246-wyanwvxa	72	7	target	target	VB
cord-282246-wyanwvxa	72	8	several	several	JJ
cord-282246-wyanwvxa	72	9	different	different	JJ
cord-282246-wyanwvxa	72	10	host	host	NN
cord-282246-wyanwvxa	72	11	factors	factor	NNS
cord-282246-wyanwvxa	72	12	that	that	WDT
cord-282246-wyanwvxa	72	13	regulate	regulate	VBP
cord-282246-wyanwvxa	72	14	the	the	DT
cord-282246-wyanwvxa	72	15	IFN	IFN	NNP
cord-282246-wyanwvxa	72	16	pathway	pathway	NN
cord-282246-wyanwvxa	72	17	[	[	-LRB-
cord-282246-wyanwvxa	72	18	40	40	CD
cord-282246-wyanwvxa	72	19	]	]	-RRB-
cord-282246-wyanwvxa	72	20	.	.	.
cord-282246-wyanwvxa	73	1	This	this	DT
cord-282246-wyanwvxa	73	2	multipronged	multipronge	VBN
cord-282246-wyanwvxa	73	3	subversion	subversion	NN
cord-282246-wyanwvxa	73	4	of	of	IN
cord-282246-wyanwvxa	73	5	the	the	DT
cord-282246-wyanwvxa	73	6	IFN	IFN	NNP
cord-282246-wyanwvxa	73	7	response	response	NN
cord-282246-wyanwvxa	73	8	is	be	VBZ
cord-282246-wyanwvxa	73	9	accomplished	accomplish	VBN
cord-282246-wyanwvxa	73	10	primarily	primarily	RB
cord-282246-wyanwvxa	73	11	by	by	IN
cord-282246-wyanwvxa	73	12	the	the	DT
cord-282246-wyanwvxa	73	13	versatile	versatile	JJ
cord-282246-wyanwvxa	73	14	RV	RV	NNP
cord-282246-wyanwvxa	73	15	nonstructural	nonstructural	JJ
cord-282246-wyanwvxa	73	16	NSP1	NSP1	NNP
cord-282246-wyanwvxa	73	17	protein	protein	NN
cord-282246-wyanwvxa	73	18	,	,	,
cord-282246-wyanwvxa	73	19	the	the	DT
cord-282246-wyanwvxa	73	20	product	product	NN
cord-282246-wyanwvxa	73	21	of	of	IN
cord-282246-wyanwvxa	73	22	RV	RV	NNP
cord-282246-wyanwvxa	73	23	gene	gene	NN
cord-282246-wyanwvxa	73	24	5	5	CD
cord-282246-wyanwvxa	73	25	(	(	-LRB-
cord-282246-wyanwvxa	73	26	see	see	VB
cord-282246-wyanwvxa	73	27	below	below	RB
cord-282246-wyanwvxa	73	28	)	)	-RRB-
cord-282246-wyanwvxa	73	29	.	.	.
cord-282246-wyanwvxa	74	1	Most	Most	JJS
cord-282246-wyanwvxa	74	2	IFN	IFN	NNP
cord-282246-wyanwvxa	74	3	-	-	HYPH
cord-282246-wyanwvxa	74	4	sensitive	sensitive	JJ
cord-282246-wyanwvxa	74	5	RV	RV	NNP
cord-282246-wyanwvxa	74	6	strains	strain	NNS
cord-282246-wyanwvxa	74	7	encode	encode	VBP
cord-282246-wyanwvxa	74	8	forms	form	NNS
cord-282246-wyanwvxa	74	9	of	of	IN
cord-282246-wyanwvxa	74	10	NSP1	NSP1	NNP
cord-282246-wyanwvxa	74	11	that	that	WDT
cord-282246-wyanwvxa	74	12	exhibit	exhibit	VBP
cord-282246-wyanwvxa	74	13	defective	defective	JJ
cord-282246-wyanwvxa	74	14	IFN	IFN	NNP
cord-282246-wyanwvxa	74	15	inhibition	inhibition	NN
cord-282246-wyanwvxa	74	16	and	and	CC
cord-282246-wyanwvxa	74	17	therefore	therefore	RB
cord-282246-wyanwvxa	74	18	elicit	elicit	VB
cord-282246-wyanwvxa	74	19	enhanced	enhance	VBN
cord-282246-wyanwvxa	74	20	IFN	IFN	NNP
cord-282246-wyanwvxa	74	21	secretion	secretion	NN
cord-282246-wyanwvxa	74	22	[	[	-LRB-
cord-282246-wyanwvxa	74	23	40À48	40à48	CD
cord-282246-wyanwvxa	74	24	]	]	-RRB-
cord-282246-wyanwvxa	74	25	.	.	.
cord-282246-wyanwvxa	75	1	Although	although	IN
cord-282246-wyanwvxa	75	2	such	such	JJ
cord-282246-wyanwvxa	75	3	strains	strain	NNS
cord-282246-wyanwvxa	75	4	are	be	VBP
cord-282246-wyanwvxa	75	5	still	still	RB
cord-282246-wyanwvxa	75	6	viable	viable	JJ
cord-282246-wyanwvxa	75	7	infectious	infectious	JJ
cord-282246-wyanwvxa	75	8	agents	agent	NNS
cord-282246-wyanwvxa	75	9	,	,	,
cord-282246-wyanwvxa	75	10	their	-PRON-	PRP$
cord-282246-wyanwvxa	75	11	ability	ability	NN
cord-282246-wyanwvxa	75	12	to	to	TO
cord-282246-wyanwvxa	75	13	replicate	replicate	VB
cord-282246-wyanwvxa	75	14	is	be	VBZ
cord-282246-wyanwvxa	75	15	substantially	substantially	RB
cord-282246-wyanwvxa	75	16	hampered	hamper	VBN
cord-282246-wyanwvxa	75	17	.	.	.
cord-282246-wyanwvxa	76	1	In	in	IN
cord-282246-wyanwvxa	76	2	addition	addition	NN
cord-282246-wyanwvxa	76	3	,	,	,
cord-282246-wyanwvxa	76	4	IFN	IFN	NNP
cord-282246-wyanwvxa	76	5	sensitivity	sensitivity	NN
cord-282246-wyanwvxa	76	6	of	of	IN
cord-282246-wyanwvxa	76	7	RVs	rv	NNS
cord-282246-wyanwvxa	76	8	encoding	encode	VBG
cord-282246-wyanwvxa	76	9	full	full	JJ
cord-282246-wyanwvxa	76	10	-	-	HYPH
cord-282246-wyanwvxa	76	11	length	length	NN
cord-282246-wyanwvxa	76	12	"	"	``
cord-282246-wyanwvxa	76	13	functional	functional	JJ
cord-282246-wyanwvxa	76	14	"	"	''
cord-282246-wyanwvxa	76	15	NSP1	nsp1	NN
cord-282246-wyanwvxa	76	16	proteins	protein	NNS
cord-282246-wyanwvxa	76	17	also	also	RB
cord-282246-wyanwvxa	76	18	occurs	occur	VBZ
cord-282246-wyanwvxa	76	19	in	in	IN
cord-282246-wyanwvxa	76	20	specific	specific	JJ
cord-282246-wyanwvxa	76	21	cell	cell	NN
cord-282246-wyanwvxa	76	22	lines	line	NNS
cord-282246-wyanwvxa	76	23	,	,	,
cord-282246-wyanwvxa	76	24	possibly	possibly	RB
cord-282246-wyanwvxa	76	25	reflecting	reflect	VBG
cord-282246-wyanwvxa	76	26	NSP1	NSP1	NNP
cord-282246-wyanwvxa	76	27	's	's	POS
cord-282246-wyanwvxa	76	28	inability	inability	NN
cord-282246-wyanwvxa	76	29	to	to	TO
cord-282246-wyanwvxa	76	30	target	target	VB
cord-282246-wyanwvxa	76	31	host	host	NN
cord-282246-wyanwvxa	76	32	innate	innate	JJ
cord-282246-wyanwvxa	76	33	factors	factor	NNS
cord-282246-wyanwvxa	76	34	across	across	IN
cord-282246-wyanwvxa	76	35	different	different	JJ
cord-282246-wyanwvxa	76	36	species	specie	NNS
cord-282246-wyanwvxa	76	37	[	[	-LRB-
cord-282246-wyanwvxa	76	38	49	49	CD
cord-282246-wyanwvxa	76	39	]	]	-RRB-
cord-282246-wyanwvxa	76	40	.	.	.
cord-282246-wyanwvxa	77	1	Enteric	enteric	JJ
cord-282246-wyanwvxa	77	2	infection	infection	NN
cord-282246-wyanwvxa	77	3	of	of	IN
cord-282246-wyanwvxa	77	4	suckling	suckle	VBG
cord-282246-wyanwvxa	78	1	(	(	-LRB-
cord-282246-wyanwvxa	78	2	i.e.	i.e.	FW
cord-282246-wyanwvxa	78	3	,	,	,
cord-282246-wyanwvxa	78	4	3-to	3-to	CD
cord-282246-wyanwvxa	78	5	5-dayold	5-dayold	CD
cord-282246-wyanwvxa	78	6	)	)	-RRB-
cord-282246-wyanwvxa	78	7	mice	mouse	NNS
cord-282246-wyanwvxa	78	8	with	with	IN
cord-282246-wyanwvxa	78	9	a	a	DT
cord-282246-wyanwvxa	78	10	homologous	homologous	JJ
cord-282246-wyanwvxa	78	11	murine	murine	NN
cord-282246-wyanwvxa	78	12	RV	rv	NN
cord-282246-wyanwvxa	78	13	compared	compare	VBN
cord-282246-wyanwvxa	78	14	to	to	IN
cord-282246-wyanwvxa	78	15	a	a	DT
cord-282246-wyanwvxa	78	16	heterologous	heterologous	JJ
cord-282246-wyanwvxa	78	17	simian	simian	JJ
cord-282246-wyanwvxa	78	18	RV	RV	NNP
cord-282246-wyanwvxa	78	19	strain	strain	NN
cord-282246-wyanwvxa	78	20	reveals	reveal	VBZ
cord-282246-wyanwvxa	78	21	a	a	DT
cord-282246-wyanwvxa	78	22	substantial	substantial	JJ
cord-282246-wyanwvxa	78	23	(	(	-LRB-
cord-282246-wyanwvxa	78	24	B4À5	B4À5	NNP
cord-282246-wyanwvxa	78	25	log	log	NN
cord-282246-wyanwvxa	78	26	)	)	-RRB-
cord-282246-wyanwvxa	78	27	host	host	NN
cord-282246-wyanwvxa	78	28	restriction	restriction	NN
cord-282246-wyanwvxa	78	29	of	of	IN
cord-282246-wyanwvxa	78	30	the	the	DT
cord-282246-wyanwvxa	78	31	simian	simian	JJ
cord-282246-wyanwvxa	78	32	RV	RV	NNP
cord-282246-wyanwvxa	78	33	replication	replication	NN
cord-282246-wyanwvxa	78	34	in	in	IN
cord-282246-wyanwvxa	78	35	the	the	DT
cord-282246-wyanwvxa	78	36	intestine	intestine	NN
cord-282246-wyanwvxa	78	37	[	[	-LRB-
cord-282246-wyanwvxa	78	38	7	7	CD
cord-282246-wyanwvxa	78	39	,	,	,
cord-282246-wyanwvxa	78	40	26	26	CD
cord-282246-wyanwvxa	78	41	,	,	,
cord-282246-wyanwvxa	78	42	50	50	CD
cord-282246-wyanwvxa	78	43	,	,	,
cord-282246-wyanwvxa	78	44	51	51	CD
cord-282246-wyanwvxa	78	45	]	]	-RRB-
cord-282246-wyanwvxa	78	46	.	.	.
cord-282246-wyanwvxa	79	1	This	this	DT
cord-282246-wyanwvxa	79	2	host	host	NN
cord-282246-wyanwvxa	79	3	restriction	restriction	NN
cord-282246-wyanwvxa	79	4	phenotype	phenotype	NN
cord-282246-wyanwvxa	79	5	is	be	VBZ
cord-282246-wyanwvxa	79	6	substantially	substantially	RB
cord-282246-wyanwvxa	79	7	reduced	reduce	VBN
cord-282246-wyanwvxa	79	8	(	(	-LRB-
cord-282246-wyanwvxa	79	9	down	down	RB
cord-282246-wyanwvxa	79	10	to	to	IN
cord-282246-wyanwvxa	79	11	1	1	CD
cord-282246-wyanwvxa	79	12	log	log	NN
cord-282246-wyanwvxa	79	13	or	or	CC
cord-282246-wyanwvxa	79	14	less	less	JJR
cord-282246-wyanwvxa	79	15	)	)	-RRB-
cord-282246-wyanwvxa	79	16	in	in	IN
cord-282246-wyanwvxa	79	17	mice	mouse	NNS
cord-282246-wyanwvxa	79	18	lacking	lack	VBG
cord-282246-wyanwvxa	79	19	and	and	CC
cord-282246-wyanwvxa	79	20	three	three	CD
cord-282246-wyanwvxa	79	21	IFN	IFN	NNP
cord-282246-wyanwvxa	79	22	receptors	receptor	NNS
cord-282246-wyanwvxa	79	23	(	(	-LRB-
cord-282246-wyanwvxa	79	24	IFNRs	IFNRs	NNPS
cord-282246-wyanwvxa	79	25	)	)	-RRB-
cord-282246-wyanwvxa	79	26	or	or	CC
cord-282246-wyanwvxa	79	27	STAT1	stat1	XX
cord-282246-wyanwvxa	79	28	,	,	,
cord-282246-wyanwvxa	79	29	a	a	DT
cord-282246-wyanwvxa	79	30	key	key	JJ
cord-282246-wyanwvxa	79	31	transcription	transcription	NN
cord-282246-wyanwvxa	79	32	factor	factor	NN
cord-282246-wyanwvxa	79	33	relaying	relay	VBG
cord-282246-wyanwvxa	79	34	antiviral	antiviral	JJ
cord-282246-wyanwvxa	79	35	signals	signal	NNS
cord-282246-wyanwvxa	79	36	from	from	IN
cord-282246-wyanwvxa	79	37	different	different	JJ
cord-282246-wyanwvxa	79	38	IFNRs	ifnr	NNS
cord-282246-wyanwvxa	79	39	[	[	-LRB-
cord-282246-wyanwvxa	79	40	7	7	CD
cord-282246-wyanwvxa	79	41	,	,	,
cord-282246-wyanwvxa	79	42	26	26	CD
cord-282246-wyanwvxa	79	43	,	,	,
cord-282246-wyanwvxa	79	44	50	50	CD
cord-282246-wyanwvxa	79	45	,	,	,
cord-282246-wyanwvxa	79	46	51	51	CD
cord-282246-wyanwvxa	79	47	]	]	-RRB-
cord-282246-wyanwvxa	79	48	.	.	.
cord-282246-wyanwvxa	80	1	The	the	DT
cord-282246-wyanwvxa	80	2	replication	replication	NN
cord-282246-wyanwvxa	80	3	phenotype	phenotype	NN
cord-282246-wyanwvxa	80	4	strongly	strongly	RB
cord-282246-wyanwvxa	80	5	cosegregates	cosegregate	VBZ
cord-282246-wyanwvxa	80	6	with	with	IN
cord-282246-wyanwvxa	80	7	the	the	DT
cord-282246-wyanwvxa	80	8	genetic	genetic	JJ
cord-282246-wyanwvxa	80	9	origin	origin	NN
cord-282246-wyanwvxa	80	10	of	of	IN
cord-282246-wyanwvxa	80	11	the	the	DT
cord-282246-wyanwvxa	80	12	VI	VI	NNP
cord-282246-wyanwvxa	80	13	.	.	.
cord-282246-wyanwvxa	81	1	MUCOSAL	MUCOSAL	NNP
cord-282246-wyanwvxa	81	2	VACCINES	vaccine	NNS
cord-282246-wyanwvxa	81	3	FOR	for	IN
cord-282246-wyanwvxa	81	4	VIRAL	viral	JJ
cord-282246-wyanwvxa	81	5	DISEASES	disease	NNS
cord-282246-wyanwvxa	81	6	murine	murine	JJ
cord-282246-wyanwvxa	81	7	or	or	CC
cord-282246-wyanwvxa	81	8	simian	simian	JJ
cord-282246-wyanwvxa	81	9	RV	RV	NNP
cord-282246-wyanwvxa	81	10	NSP1	NSP1	NNP
cord-282246-wyanwvxa	81	11	encoding	encode	VBG
cord-282246-wyanwvxa	81	12	gene	gene	NN
cord-282246-wyanwvxa	81	13	5	5	CD
cord-282246-wyanwvxa	81	14	segments	segment	NNS
cord-282246-wyanwvxa	81	15	.	.	.
cord-282246-wyanwvxa	82	1	The	the	DT
cord-282246-wyanwvxa	82	2	suckling	suckle	VBG
cord-282246-wyanwvxa	82	3	mouse	mouse	NN
cord-282246-wyanwvxa	82	4	thus	thus	RB
cord-282246-wyanwvxa	82	5	presents	present	VBZ
cord-282246-wyanwvxa	82	6	a	a	DT
cord-282246-wyanwvxa	82	7	highly	highly	RB
cord-282246-wyanwvxa	82	8	tractable	tractable	JJ
cord-282246-wyanwvxa	82	9	model	model	NN
cord-282246-wyanwvxa	82	10	in	in	IN
cord-282246-wyanwvxa	82	11	which	which	WDT
cord-282246-wyanwvxa	82	12	IFN	IFN	NNP
cord-282246-wyanwvxa	82	13	-	-	HYPH
cord-282246-wyanwvxa	82	14	specific	specific	JJ
cord-282246-wyanwvxa	82	15	effects	effect	NNS
cord-282246-wyanwvxa	82	16	on	on	IN
cord-282246-wyanwvxa	82	17	RV	rv	NN
cord-282246-wyanwvxa	82	18	replication	replication	NN
cord-282246-wyanwvxa	82	19	can	can	MD
cord-282246-wyanwvxa	82	20	be	be	VB
cord-282246-wyanwvxa	82	21	studied	study	VBN
cord-282246-wyanwvxa	82	22	within	within	IN
cord-282246-wyanwvxa	82	23	the	the	DT
cord-282246-wyanwvxa	82	24	biologically	biologically	RB
cord-282246-wyanwvxa	82	25	relevant	relevant	JJ
cord-282246-wyanwvxa	82	26	framework	framework	NN
cord-282246-wyanwvxa	82	27	of	of	IN
cord-282246-wyanwvxa	82	28	intestinal	intestinal	JJ
cord-282246-wyanwvxa	82	29	RV	rv	NN
cord-282246-wyanwvxa	82	30	replication	replication	NN
cord-282246-wyanwvxa	82	31	in	in	IN
cord-282246-wyanwvxa	82	32	a	a	DT
cord-282246-wyanwvxa	82	33	natural	natural	JJ
cord-282246-wyanwvxa	82	34	host	host	NN
cord-282246-wyanwvxa	82	35	and	and	CC
cord-282246-wyanwvxa	82	36	in	in	IN
cord-282246-wyanwvxa	82	37	a	a	DT
cord-282246-wyanwvxa	82	38	host	host	NN
cord-282246-wyanwvxa	82	39	-	-	HYPH
cord-282246-wyanwvxa	82	40	range	range	NN
cord-282246-wyanwvxa	82	41	-	-	HYPH
cord-282246-wyanwvxa	82	42	restricted	restrict	VBN
cord-282246-wyanwvxa	82	43	manner	manner	NN
cord-282246-wyanwvxa	82	44	.	.	.
cord-282246-wyanwvxa	83	1	Ectopic	ectopic	JJ
cord-282246-wyanwvxa	83	2	parenteral	parenteral	JJ
cord-282246-wyanwvxa	83	3	injection	injection	NN
cord-282246-wyanwvxa	83	4	of	of	IN
cord-282246-wyanwvxa	83	5	purified	purify	VBN
cord-282246-wyanwvxa	83	6	IFN	IFN	NNP
cord-282246-wyanwvxa	83	7	types	type	NNS
cord-282246-wyanwvxa	83	8	I	-PRON-	PRP
cord-282246-wyanwvxa	83	9	,	,	,
cord-282246-wyanwvxa	83	10	II	II	NNP
cord-282246-wyanwvxa	83	11	,	,	,
cord-282246-wyanwvxa	83	12	or	or	CC
cord-282246-wyanwvxa	83	13	III	iii	CD
cord-282246-wyanwvxa	83	14	in	in	IN
cord-282246-wyanwvxa	83	15	many	many	JJ
cord-282246-wyanwvxa	83	16	species	specie	NNS
cord-282246-wyanwvxa	83	17	,	,	,
cord-282246-wyanwvxa	83	18	including	include	VBG
cord-282246-wyanwvxa	83	19	mice	mouse	NNS
cord-282246-wyanwvxa	83	20	,	,	,
cord-282246-wyanwvxa	83	21	results	result	NNS
cord-282246-wyanwvxa	83	22	in	in	IN
cord-282246-wyanwvxa	83	23	the	the	DT
cord-282246-wyanwvxa	83	24	activation	activation	NN
cord-282246-wyanwvxa	83	25	of	of	IN
cord-282246-wyanwvxa	83	26	the	the	DT
cord-282246-wyanwvxa	83	27	key	key	JJ
cord-282246-wyanwvxa	83	28	downstream	downstream	JJ
cord-282246-wyanwvxa	83	29	transcription	transcription	NN
cord-282246-wyanwvxa	83	30	factor	factor	NN
cord-282246-wyanwvxa	83	31	STAT1	stat1	XX
cord-282246-wyanwvxa	83	32	in	in	IN
cord-282246-wyanwvxa	83	33	small	small	JJ
cord-282246-wyanwvxa	83	34	IECs	iec	NNS
cord-282246-wyanwvxa	83	35	(	(	-LRB-
cord-282246-wyanwvxa	83	36	the	the	DT
cord-282246-wyanwvxa	83	37	predominant	predominant	JJ
cord-282246-wyanwvxa	83	38	site	site	NN
cord-282246-wyanwvxa	83	39	of	of	IN
cord-282246-wyanwvxa	83	40	RV	RV	NNP
cord-282246-wyanwvxa	83	41	replication	replication	NN
cord-282246-wyanwvxa	83	42	)	)	-RRB-
cord-282246-wyanwvxa	84	1	[	[	-LRB-
cord-282246-wyanwvxa	84	2	52	52	CD
cord-282246-wyanwvxa	84	3	]	]	-RRB-
cord-282246-wyanwvxa	84	4	.	.	.
cord-282246-wyanwvxa	85	1	Multiple	multiple	JJ
cord-282246-wyanwvxa	85	2	lines	line	NNS
cord-282246-wyanwvxa	85	3	of	of	IN
cord-282246-wyanwvxa	85	4	evidence	evidence	NN
cord-282246-wyanwvxa	85	5	indicate	indicate	VBP
cord-282246-wyanwvxa	85	6	important	important	JJ
cord-282246-wyanwvxa	85	7	roles	role	NNS
cord-282246-wyanwvxa	85	8	for	for	IN
cord-282246-wyanwvxa	85	9	IFN	IFN	NNP
cord-282246-wyanwvxa	85	10	types	type	NNS
cord-282246-wyanwvxa	85	11	I	-PRON-	PRP
cord-282246-wyanwvxa	85	12	,	,	,
cord-282246-wyanwvxa	85	13	II	II	NNP
cord-282246-wyanwvxa	85	14	,	,	,
cord-282246-wyanwvxa	85	15	and	and	CC
cord-282246-wyanwvxa	85	16	III	iii	CD
cord-282246-wyanwvxa	85	17	in	in	IN
cord-282246-wyanwvxa	85	18	restricting	restrict	VBG
cord-282246-wyanwvxa	85	19	RV	rv	NN
cord-282246-wyanwvxa	85	20	replication	replication	NN
cord-282246-wyanwvxa	85	21	in	in	IN
cord-282246-wyanwvxa	85	22	the	the	DT
cord-282246-wyanwvxa	85	23	gut	gut	NN
cord-282246-wyanwvxa	85	24	and	and	CC
cord-282246-wyanwvxa	85	25	in	in	IN
cord-282246-wyanwvxa	85	26	cell	cell	NN
cord-282246-wyanwvxa	85	27	culture	culture	NN
cord-282246-wyanwvxa	85	28	[	[	-LRB-
cord-282246-wyanwvxa	85	29	7	7	CD
cord-282246-wyanwvxa	85	30	,	,	,
cord-282246-wyanwvxa	85	31	26	26	CD
cord-282246-wyanwvxa	85	32	,	,	,
cord-282246-wyanwvxa	85	33	50	50	CD
cord-282246-wyanwvxa	85	34	,	,	,
cord-282246-wyanwvxa	85	35	51	51	CD
cord-282246-wyanwvxa	85	36	,	,	,
cord-282246-wyanwvxa	85	37	53	53	CD
cord-282246-wyanwvxa	85	38	]	]	-RRB-
cord-282246-wyanwvxa	85	39	.	.	.
cord-282246-wyanwvxa	86	1	In	in	IN
cord-282246-wyanwvxa	86	2	mouse	mouse	NN
cord-282246-wyanwvxa	86	3	embryonic	embryonic	JJ
cord-282246-wyanwvxa	86	4	fibroblasts	fibroblast	NNS
cord-282246-wyanwvxa	86	5	lacking	lack	VBG
cord-282246-wyanwvxa	86	6	both	both	DT
cord-282246-wyanwvxa	86	7	types	type	NNS
cord-282246-wyanwvxa	86	8	I	-PRON-	PRP
cord-282246-wyanwvxa	86	9	and	and	CC
cord-282246-wyanwvxa	86	10	II	II	NNP
cord-282246-wyanwvxa	86	11	IFNRs	IFNRs	NNPS
cord-282246-wyanwvxa	86	12	,	,	,
cord-282246-wyanwvxa	86	13	the	the	DT
cord-282246-wyanwvxa	86	14	replication	replication	NN
cord-282246-wyanwvxa	86	15	of	of	IN
cord-282246-wyanwvxa	86	16	several	several	JJ
cord-282246-wyanwvxa	86	17	nonmurine	nonmurine	JJ
cord-282246-wyanwvxa	86	18	RV	RV	NNP
cord-282246-wyanwvxa	86	19	strains	strain	NNS
cord-282246-wyanwvxa	86	20	is	be	VBZ
cord-282246-wyanwvxa	86	21	substantially	substantially	RB
cord-282246-wyanwvxa	86	22	enhanced	enhance	VBN
cord-282246-wyanwvxa	86	23	(	(	-LRB-
cord-282246-wyanwvxa	86	24	by	by	IN
cord-282246-wyanwvxa	86	25	four	four	CD
cord-282246-wyanwvxa	86	26	to	to	TO
cord-282246-wyanwvxa	86	27	five	five	CD
cord-282246-wyanwvxa	86	28	orders	order	NNS
cord-282246-wyanwvxa	86	29	of	of	IN
cord-282246-wyanwvxa	86	30	magnitude	magnitude	NN
cord-282246-wyanwvxa	86	31	)	)	-RRB-
cord-282246-wyanwvxa	86	32	.	.	.
cord-282246-wyanwvxa	87	1	In	in	IN
cord-282246-wyanwvxa	87	2	suckling	suckle	VBG
cord-282246-wyanwvxa	87	3	mice	mouse	NNS
cord-282246-wyanwvxa	87	4	lacking	lack	VBG
cord-282246-wyanwvxa	87	5	the	the	DT
cord-282246-wyanwvxa	87	6	types	type	NNS
cord-282246-wyanwvxa	88	1	I	-PRON-	PRP
cord-282246-wyanwvxa	88	2	,	,	,
cord-282246-wyanwvxa	88	3	II	II	NNP
cord-282246-wyanwvxa	88	4	,	,	,
cord-282246-wyanwvxa	88	5	and	and	CC
cord-282246-wyanwvxa	88	6	III	iii	CD
cord-282246-wyanwvxa	88	7	IFNRs	ifnr	NNS
cord-282246-wyanwvxa	88	8	(	(	-LRB-
cord-282246-wyanwvxa	88	9	either	either	CC
cord-282246-wyanwvxa	88	10	singly	singly	RB
cord-282246-wyanwvxa	88	11	or	or	CC
cord-282246-wyanwvxa	88	12	in	in	IN
cord-282246-wyanwvxa	88	13	combination	combination	NN
cord-282246-wyanwvxa	88	14	)	)	-RRB-
cord-282246-wyanwvxa	88	15	significant	significant	JJ
cord-282246-wyanwvxa	88	16	enhancement	enhancement	NN
cord-282246-wyanwvxa	88	17	of	of	IN
cord-282246-wyanwvxa	88	18	simian	simian	JJ
cord-282246-wyanwvxa	88	19	RV	RV	NNP
cord-282246-wyanwvxa	88	20	intestinal	intestinal	JJ
cord-282246-wyanwvxa	88	21	replication	replication	NN
cord-282246-wyanwvxa	88	22	occurs	occur	VBZ
cord-282246-wyanwvxa	88	23	demonstrating	demonstrate	VBG
cord-282246-wyanwvxa	88	24	the	the	DT
cord-282246-wyanwvxa	88	25	sensitivity	sensitivity	NN
cord-282246-wyanwvxa	88	26	of	of	IN
cord-282246-wyanwvxa	88	27	heterologous	heterologous	NNP
cord-282246-wyanwvxa	88	28	nonmurine	nonmurine	NNP
cord-282246-wyanwvxa	88	29	RVs	rv	NNS
cord-282246-wyanwvxa	88	30	to	to	TO
cord-282246-wyanwvxa	88	31	different	different	JJ
cord-282246-wyanwvxa	88	32	IFN	IFN	NNP
cord-282246-wyanwvxa	88	33	types	type	NNS
cord-282246-wyanwvxa	88	34	in	in	IN
cord-282246-wyanwvxa	88	35	the	the	DT
cord-282246-wyanwvxa	88	36	mouse	mouse	NN
cord-282246-wyanwvxa	88	37	gut	gut	NN
cord-282246-wyanwvxa	88	38	[	[	-LRB-
cord-282246-wyanwvxa	88	39	7	7	CD
cord-282246-wyanwvxa	88	40	,	,	,
cord-282246-wyanwvxa	88	41	26	26	CD
cord-282246-wyanwvxa	88	42	,	,	,
cord-282246-wyanwvxa	88	43	50	50	CD
cord-282246-wyanwvxa	88	44	,	,	,
cord-282246-wyanwvxa	88	45	51	51	CD
cord-282246-wyanwvxa	88	46	]	]	-RRB-
cord-282246-wyanwvxa	88	47	.	.	.
cord-282246-wyanwvxa	89	1	In	in	IN
cord-282246-wyanwvxa	89	2	contrast	contrast	NN
cord-282246-wyanwvxa	89	3	,	,	,
cord-282246-wyanwvxa	89	4	replication	replication	NN
cord-282246-wyanwvxa	89	5	of	of	IN
cord-282246-wyanwvxa	89	6	the	the	DT
cord-282246-wyanwvxa	89	7	homologous	homologous	JJ
cord-282246-wyanwvxa	89	8	murine	murine	NN
cord-282246-wyanwvxa	89	9	RV	RV	NNP
cord-282246-wyanwvxa	89	10	is	be	VBZ
cord-282246-wyanwvxa	89	11	quite	quite	RB
cord-282246-wyanwvxa	89	12	resistant	resistant	JJ
cord-282246-wyanwvxa	89	13	to	to	IN
cord-282246-wyanwvxa	89	14	these	these	DT
cord-282246-wyanwvxa	89	15	IFNs	ifn	NNS
cord-282246-wyanwvxa	89	16	(	(	-LRB-
cord-282246-wyanwvxa	89	17	B1	b1	NN
cord-282246-wyanwvxa	89	18	log	log	NN
cord-282246-wyanwvxa	89	19	or	or	CC
cord-282246-wyanwvxa	89	20	less	less	JJR
cord-282246-wyanwvxa	89	21	replication	replication	NN
cord-282246-wyanwvxa	89	22	gain	gain	NN
cord-282246-wyanwvxa	89	23	)	)	-RRB-
cord-282246-wyanwvxa	89	24	.	.	.
cord-282246-wyanwvxa	90	1	The	the	DT
cord-282246-wyanwvxa	90	2	collective	collective	JJ
cord-282246-wyanwvxa	90	3	evidence	evidence	NN
cord-282246-wyanwvxa	90	4	thus	thus	RB
cord-282246-wyanwvxa	90	5	highlights	highlight	VBZ
cord-282246-wyanwvxa	90	6	the	the	DT
cord-282246-wyanwvxa	90	7	important	important	JJ
cord-282246-wyanwvxa	90	8	role	role	NN
cord-282246-wyanwvxa	90	9	of	of	IN
cord-282246-wyanwvxa	90	10	different	different	JJ
cord-282246-wyanwvxa	90	11	types	type	NNS
cord-282246-wyanwvxa	90	12	of	of	IN
cord-282246-wyanwvxa	90	13	IFNs	ifn	NNS
cord-282246-wyanwvxa	90	14	(	(	-LRB-
cord-282246-wyanwvxa	90	15	and	and	CC
cord-282246-wyanwvxa	90	16	their	-PRON-	PRP$
cord-282246-wyanwvxa	90	17	inhibition	inhibition	NN
cord-282246-wyanwvxa	90	18	by	by	IN
cord-282246-wyanwvxa	90	19	the	the	DT
cord-282246-wyanwvxa	90	20	RV	RV	NNP
cord-282246-wyanwvxa	90	21	NSP1	NSP1	NNP
cord-282246-wyanwvxa	90	22	protein	protein	NN
cord-282246-wyanwvxa	90	23	)	)	-RRB-
cord-282246-wyanwvxa	90	24	in	in	IN
cord-282246-wyanwvxa	90	25	RV	rv	NN
cord-282246-wyanwvxa	90	26	pathogenicity	pathogenicity	NN
cord-282246-wyanwvxa	90	27	and	and	CC
cord-282246-wyanwvxa	90	28	attenuation	attenuation	NN
cord-282246-wyanwvxa	90	29	[	[	-LRB-
cord-282246-wyanwvxa	90	30	7	7	CD
cord-282246-wyanwvxa	90	31	,	,	,
cord-282246-wyanwvxa	90	32	26	26	CD
cord-282246-wyanwvxa	90	33	,	,	,
cord-282246-wyanwvxa	90	34	50	50	CD
cord-282246-wyanwvxa	90	35	,	,	,
cord-282246-wyanwvxa	90	36	51	51	CD
cord-282246-wyanwvxa	90	37	,	,	,
cord-282246-wyanwvxa	90	38	53	53	CD
cord-282246-wyanwvxa	90	39	]	]	-RRB-
cord-282246-wyanwvxa	90	40	.	.	.
cord-282246-wyanwvxa	91	1	Deciphering	decipher	VBG
cord-282246-wyanwvxa	91	2	the	the	DT
cord-282246-wyanwvxa	91	3	mechanisms	mechanism	NNS
cord-282246-wyanwvxa	91	4	underlying	underlie	VBG
cord-282246-wyanwvxa	91	5	these	these	DT
cord-282246-wyanwvxa	91	6	interactions	interaction	NNS
cord-282246-wyanwvxa	91	7	is	be	VBZ
cord-282246-wyanwvxa	91	8	key	key	JJ
cord-282246-wyanwvxa	91	9	for	for	IN
cord-282246-wyanwvxa	91	10	rational	rational	JJ
cord-282246-wyanwvxa	91	11	RV	RV	NNP
cord-282246-wyanwvxa	91	12	strain	strain	NN
cord-282246-wyanwvxa	91	13	attenuation	attenuation	NN
cord-282246-wyanwvxa	91	14	and	and	CC
cord-282246-wyanwvxa	91	15	designing	designing	NN
cord-282246-wyanwvxa	91	16	improved	improve	VBN
cord-282246-wyanwvxa	91	17	third	third	JJ
cord-282246-wyanwvxa	91	18	-	-	HYPH
cord-282246-wyanwvxa	91	19	generation	generation	NN
cord-282246-wyanwvxa	91	20	live	live	VBP
cord-282246-wyanwvxa	91	21	attenuated	attenuated	JJ
cord-282246-wyanwvxa	91	22	RV	RV	NNP
cord-282246-wyanwvxa	91	23	vaccines	vaccine	NNS
cord-282246-wyanwvxa	91	24	.	.	.
cord-282246-wyanwvxa	92	1	In	in	IN
cord-282246-wyanwvxa	92	2	a	a	DT
cord-282246-wyanwvxa	92	3	manner	manner	NN
cord-282246-wyanwvxa	92	4	analogous	analogous	JJ
cord-282246-wyanwvxa	92	5	to	to	IN
cord-282246-wyanwvxa	92	6	that	that	DT
cord-282246-wyanwvxa	92	7	of	of	IN
cord-282246-wyanwvxa	92	8	other	other	JJ
cord-282246-wyanwvxa	92	9	RNA	RNA	NNP
cord-282246-wyanwvxa	92	10	viruses	virus	NNS
cord-282246-wyanwvxa	92	11	,	,	,
cord-282246-wyanwvxa	92	12	RV	rv	NN
cord-282246-wyanwvxa	92	13	-	-	HYPH
cord-282246-wyanwvxa	92	14	induced	induce	VBN
cord-282246-wyanwvxa	92	15	IFN	IFN	NNP
cord-282246-wyanwvxa	92	16	activation	activation	NN
cord-282246-wyanwvxa	92	17	is	be	VBZ
cord-282246-wyanwvxa	92	18	dependent	dependent	JJ
cord-282246-wyanwvxa	92	19	on	on	IN
cord-282246-wyanwvxa	92	20	an	an	DT
cord-282246-wyanwvxa	92	21	intact	intact	JJ
cord-282246-wyanwvxa	92	22	RNA	RNA	NNP
cord-282246-wyanwvxa	92	23	sensing	sensing	NN
cord-282246-wyanwvxa	92	24	pathway	pathway	NN
cord-282246-wyanwvxa	92	25	[	[	-LRB-
cord-282246-wyanwvxa	92	26	8	8	CD
cord-282246-wyanwvxa	92	27	]	]	-RRB-
cord-282246-wyanwvxa	92	28	.	.	.
cord-282246-wyanwvxa	93	1	Postrecognition	postrecognition	NN
cord-282246-wyanwvxa	93	2	of	of	IN
cord-282246-wyanwvxa	93	3	viral	viral	JJ
cord-282246-wyanwvxa	93	4	RNA	RNA	NNP
cord-282246-wyanwvxa	93	5	by	by	IN
cord-282246-wyanwvxa	93	6	the	the	DT
cord-282246-wyanwvxa	93	7	cytoplasmic	cytoplasmic	JJ
cord-282246-wyanwvxa	93	8	sensors	sensor	NNS
cord-282246-wyanwvxa	93	9	RIG	rig	NN
cord-282246-wyanwvxa	93	10	-	-	:
cord-282246-wyanwvxa	93	11	I	i	NN
cord-282246-wyanwvxa	93	12	and/or	and/or	CC
cord-282246-wyanwvxa	93	13	MDA-5	MDA-5	NNP
cord-282246-wyanwvxa	93	14	,	,	,
cord-282246-wyanwvxa	93	15	epithelial	epithelial	JJ
cord-282246-wyanwvxa	93	16	cells	cell	NNS
cord-282246-wyanwvxa	93	17	activate	activate	VBP
cord-282246-wyanwvxa	93	18	the	the	DT
cord-282246-wyanwvxa	93	19	MAVS	MAVS	NNPS
cord-282246-wyanwvxa	93	20	,	,	,
cord-282246-wyanwvxa	93	21	a	a	DT
cord-282246-wyanwvxa	93	22	mitochondriaresident	mitochondriaresident	NN
cord-282246-wyanwvxa	93	23	adaptor	adaptor	NN
cord-282246-wyanwvxa	93	24	protein	protein	NN
cord-282246-wyanwvxa	93	25	that	that	WDT
cord-282246-wyanwvxa	93	26	is	be	VBZ
cord-282246-wyanwvxa	93	27	alternatively	alternatively	RB
cord-282246-wyanwvxa	93	28	known	know	VBN
cord-282246-wyanwvxa	93	29	as	as	IN
cord-282246-wyanwvxa	93	30	IFN	IFN	NNP
cord-282246-wyanwvxa	93	31	-	-	HYPH
cord-282246-wyanwvxa	93	32	β	β	NNP
cord-282246-wyanwvxa	93	33	promoter	promoter	NN
cord-282246-wyanwvxa	93	34	stimulator	stimulator	NN
cord-282246-wyanwvxa	93	35	1	1	CD
cord-282246-wyanwvxa	93	36	(	(	-LRB-
cord-282246-wyanwvxa	93	37	IPS-1	IPS-1	NNP
cord-282246-wyanwvxa	93	38	)	)	-RRB-
cord-282246-wyanwvxa	93	39	,	,	,
cord-282246-wyanwvxa	93	40	CARD	card	NN
cord-282246-wyanwvxa	93	41	adapter	adapter	NN
cord-282246-wyanwvxa	93	42	inducing	induce	VBG
cord-282246-wyanwvxa	93	43	IFN	IFN	NNP
cord-282246-wyanwvxa	93	44	beta	beta	NN
cord-282246-wyanwvxa	93	45	(	(	-LRB-
cord-282246-wyanwvxa	93	46	Cardif	Cardif	NNP
cord-282246-wyanwvxa	93	47	)	)	-RRB-
cord-282246-wyanwvxa	93	48	,	,	,
cord-282246-wyanwvxa	93	49	or	or	CC
cord-282246-wyanwvxa	93	50	virus	virus	NN
cord-282246-wyanwvxa	93	51	-	-	HYPH
cord-282246-wyanwvxa	93	52	induced	induce	VBN
cord-282246-wyanwvxa	93	53	signaling	signal	VBG
cord-282246-wyanwvxa	93	54	adapter	adapter	NN
cord-282246-wyanwvxa	93	55	(	(	-LRB-
cord-282246-wyanwvxa	93	56	VISA	VISA	NNP
cord-282246-wyanwvxa	93	57	)	)	-RRB-
cord-282246-wyanwvxa	93	58	[	[	-LRB-
cord-282246-wyanwvxa	93	59	54À57	54à57	LS
cord-282246-wyanwvxa	93	60	]	]	-RRB-
cord-282246-wyanwvxa	93	61	.	.	.
cord-282246-wyanwvxa	94	1	MAVS	MAVS	NNP
cord-282246-wyanwvxa	94	2	serves	serve	VBZ
cord-282246-wyanwvxa	94	3	as	as	IN
cord-282246-wyanwvxa	94	4	a	a	DT
cord-282246-wyanwvxa	94	5	central	central	JJ
cord-282246-wyanwvxa	94	6	hub	hub	NN
cord-282246-wyanwvxa	94	7	in	in	IN
cord-282246-wyanwvxa	94	8	the	the	DT
cord-282246-wyanwvxa	94	9	IFN	IFN	NNP
cord-282246-wyanwvxa	94	10	induction	induction	NN
cord-282246-wyanwvxa	94	11	pathway	pathway	NN
cord-282246-wyanwvxa	94	12	by	by	IN
cord-282246-wyanwvxa	94	13	activating	activate	VBG
cord-282246-wyanwvxa	94	14	further	further	JJ
cord-282246-wyanwvxa	94	15	downstream	downstream	JJ
cord-282246-wyanwvxa	94	16	kinases	kinase	NNS
cord-282246-wyanwvxa	94	17	including	include	VBG
cord-282246-wyanwvxa	94	18	TANK	tank	NN
cord-282246-wyanwvxa	94	19	-	-	HYPH
cord-282246-wyanwvxa	94	20	binding	bind	VBG
cord-282246-wyanwvxa	94	21	kinase	kinase	NN
cord-282246-wyanwvxa	94	22	1	1	CD
cord-282246-wyanwvxa	94	23	(	(	-LRB-
cord-282246-wyanwvxa	94	24	TBK1	TBK1	NNP
cord-282246-wyanwvxa	94	25	)	)	-RRB-
cord-282246-wyanwvxa	94	26	and	and	CC
cord-282246-wyanwvxa	94	27	inhibitor	inhibitor	NN
cord-282246-wyanwvxa	94	28	of	of	IN
cord-282246-wyanwvxa	94	29	kappa	kappa	NNP
cord-282246-wyanwvxa	94	30	light	light	NNP
cord-282246-wyanwvxa	94	31	polypeptide	polypeptide	NN
cord-282246-wyanwvxa	94	32	gene	gene	NN
cord-282246-wyanwvxa	94	33	enhancer	enhancer	NN
cord-282246-wyanwvxa	94	34	in	in	IN
cord-282246-wyanwvxa	94	35	B	b	NN
cord-282246-wyanwvxa	94	36	cells	cell	NNS
cord-282246-wyanwvxa	94	37	,	,	,
cord-282246-wyanwvxa	94	38	kinase	kinase	NN
cord-282246-wyanwvxa	94	39	epsilon	epsilon	NN
cord-282246-wyanwvxa	94	40	(	(	-LRB-
cord-282246-wyanwvxa	94	41	IKK	IKK	NNP
cord-282246-wyanwvxa	94	42	-	-	HYPH
cord-282246-wyanwvxa	94	43	ε	ε	NNP
cord-282246-wyanwvxa	94	44	)	)	-RRB-
cord-282246-wyanwvxa	94	45	that	that	WDT
cord-282246-wyanwvxa	94	46	phosphorylate	phosphorylate	VBP
cord-282246-wyanwvxa	94	47	IRF3	IRF3	NNP
cord-282246-wyanwvxa	94	48	and	and	CC
cord-282246-wyanwvxa	94	49	NF	NF	NNP
cord-282246-wyanwvxa	94	50	-	-	HYPH
cord-282246-wyanwvxa	94	51	κB	κB	NNP
cord-282246-wyanwvxa	94	52	,	,	,
cord-282246-wyanwvxa	94	53	respectively	respectively	RB
cord-282246-wyanwvxa	94	54	[	[	-LRB-
cord-282246-wyanwvxa	94	55	58	58	CD
cord-282246-wyanwvxa	94	56	]	]	-RRB-
cord-282246-wyanwvxa	94	57	.	.	.
cord-282246-wyanwvxa	95	1	These	these	DT
cord-282246-wyanwvxa	95	2	molecules	molecule	NNS
cord-282246-wyanwvxa	95	3	translocate	translocate	VBP
cord-282246-wyanwvxa	95	4	into	into	IN
cord-282246-wyanwvxa	95	5	the	the	DT
cord-282246-wyanwvxa	95	6	nucleus	nucleus	NN
cord-282246-wyanwvxa	95	7	upon	upon	IN
cord-282246-wyanwvxa	95	8	phosphorylation	phosphorylation	NN
cord-282246-wyanwvxa	95	9	and	and	CC
cord-282246-wyanwvxa	95	10	function	function	NN
cord-282246-wyanwvxa	95	11	as	as	IN
cord-282246-wyanwvxa	95	12	transcription	transcription	NN
cord-282246-wyanwvxa	95	13	factors	factor	NNS
cord-282246-wyanwvxa	95	14	,	,	,
cord-282246-wyanwvxa	95	15	which	which	WDT
cord-282246-wyanwvxa	95	16	ultimately	ultimately	RB
cord-282246-wyanwvxa	95	17	leads	lead	VBZ
cord-282246-wyanwvxa	95	18	to	to	IN
cord-282246-wyanwvxa	95	19	the	the	DT
cord-282246-wyanwvxa	95	20	expression	expression	NN
cord-282246-wyanwvxa	95	21	of	of	IN
cord-282246-wyanwvxa	95	22	different	different	JJ
cord-282246-wyanwvxa	95	23	IFNs	ifn	NNS
cord-282246-wyanwvxa	95	24	and	and	CC
cord-282246-wyanwvxa	95	25	the	the	DT
cord-282246-wyanwvxa	95	26	activation	activation	NN
cord-282246-wyanwvxa	95	27	of	of	IN
cord-282246-wyanwvxa	95	28	IFNstimulated	ifnstimulate	VBN
cord-282246-wyanwvxa	95	29	response	response	NN
cord-282246-wyanwvxa	95	30	elements	element	NNS
cord-282246-wyanwvxa	95	31	(	(	-LRB-
cord-282246-wyanwvxa	95	32	ISREs	ISREs	NNP
cord-282246-wyanwvxa	95	33	)	)	-RRB-
cord-282246-wyanwvxa	95	34	.	.	.
cord-282246-wyanwvxa	96	1	In	in	IN
cord-282246-wyanwvxa	96	2	addition	addition	NN
cord-282246-wyanwvxa	96	3	to	to	IN
cord-282246-wyanwvxa	96	4	IRF3	IRF3	NNP
cord-282246-wyanwvxa	96	5	,	,	,
cord-282246-wyanwvxa	96	6	IRF7	IRF7	NNP
cord-282246-wyanwvxa	96	7	has	have	VBZ
cord-282246-wyanwvxa	96	8	been	be	VBN
cord-282246-wyanwvxa	96	9	characterized	characterize	VBN
cord-282246-wyanwvxa	96	10	as	as	IN
cord-282246-wyanwvxa	96	11	an	an	DT
cord-282246-wyanwvxa	96	12	important	important	JJ
cord-282246-wyanwvxa	96	13	transcription	transcription	NN
cord-282246-wyanwvxa	96	14	factor	factor	NN
cord-282246-wyanwvxa	96	15	for	for	IN
cord-282246-wyanwvxa	96	16	type	type	NN
cord-282246-wyanwvxa	96	17	I	-PRON-	PRP
cord-282246-wyanwvxa	96	18	IFN	IFN	NNP
cord-282246-wyanwvxa	96	19	induction	induction	NN
cord-282246-wyanwvxa	96	20	in	in	IN
cord-282246-wyanwvxa	96	21	immune	immune	JJ
cord-282246-wyanwvxa	96	22	cells	cell	NNS
cord-282246-wyanwvxa	96	23	,	,	,
cord-282246-wyanwvxa	96	24	in	in	IN
cord-282246-wyanwvxa	96	25	particular	particular	JJ
cord-282246-wyanwvxa	96	26	dendritic	dendritic	JJ
cord-282246-wyanwvxa	96	27	cells	cell	NNS
cord-282246-wyanwvxa	96	28	[	[	-LRB-
cord-282246-wyanwvxa	96	29	59	59	CD
cord-282246-wyanwvxa	96	30	]	]	-RRB-
cord-282246-wyanwvxa	96	31	.	.	.
cord-282246-wyanwvxa	97	1	Similar	similar	JJ
cord-282246-wyanwvxa	97	2	to	to	IN
cord-282246-wyanwvxa	97	3	IRF3	IRF3	NNP
cord-282246-wyanwvxa	97	4	,	,	,
cord-282246-wyanwvxa	97	5	IRF7	IRF7	NNP
cord-282246-wyanwvxa	97	6	undergoes	undergo	VBZ
cord-282246-wyanwvxa	97	7	phosphorylation	phosphorylation	NN
cord-282246-wyanwvxa	97	8	and	and	CC
cord-282246-wyanwvxa	97	9	subsequent	subsequent	JJ
cord-282246-wyanwvxa	97	10	translocation	translocation	NN
cord-282246-wyanwvxa	97	11	into	into	IN
cord-282246-wyanwvxa	97	12	the	the	DT
cord-282246-wyanwvxa	97	13	nucleus	nucleus	NN
cord-282246-wyanwvxa	97	14	in	in	IN
cord-282246-wyanwvxa	97	15	response	response	NN
cord-282246-wyanwvxa	97	16	to	to	IN
cord-282246-wyanwvxa	97	17	RV	rv	NN
cord-282246-wyanwvxa	97	18	infection	infection	NN
cord-282246-wyanwvxa	97	19	and	and	CC
cord-282246-wyanwvxa	97	20	activates	activate	VBZ
cord-282246-wyanwvxa	97	21	IFN	IFN	NNP
cord-282246-wyanwvxa	97	22	expression	expression	NN
cord-282246-wyanwvxa	97	23	by	by	IN
cord-282246-wyanwvxa	97	24	functioning	function	VBG
cord-282246-wyanwvxa	97	25	as	as	IN
cord-282246-wyanwvxa	97	26	transcription	transcription	NN
cord-282246-wyanwvxa	97	27	factors	factor	NNS
cord-282246-wyanwvxa	97	28	.	.	.
cord-282246-wyanwvxa	98	1	To	to	TO
cord-282246-wyanwvxa	98	2	block	block	VB
cord-282246-wyanwvxa	98	3	such	such	PDT
cord-282246-wyanwvxa	98	4	an	an	DT
cord-282246-wyanwvxa	98	5	important	important	JJ
cord-282246-wyanwvxa	98	6	pathway	pathway	NN
cord-282246-wyanwvxa	98	7	,	,	,
cord-282246-wyanwvxa	98	8	the	the	DT
cord-282246-wyanwvxa	98	9	RV	RV	NNP
cord-282246-wyanwvxa	98	10	-	-	HYPH
cord-282246-wyanwvxa	98	11	encoded	encode	VBN
cord-282246-wyanwvxa	98	12	NSP1	NSP1	NNP
cord-282246-wyanwvxa	98	13	protein	protein	NN
cord-282246-wyanwvxa	98	14	efficiently	efficiently	RB
cord-282246-wyanwvxa	98	15	degrades	degrade	VBZ
cord-282246-wyanwvxa	98	16	both	both	CC
cord-282246-wyanwvxa	98	17	IRF3	IRF3	NNP
cord-282246-wyanwvxa	98	18	and	and	CC
cord-282246-wyanwvxa	98	19	IRF7	IRF7	NNP
cord-282246-wyanwvxa	98	20	in	in	IN
cord-282246-wyanwvxa	98	21	a	a	DT
cord-282246-wyanwvxa	98	22	virus	virus	NN
cord-282246-wyanwvxa	98	23	-	-	HYPH
cord-282246-wyanwvxa	98	24	strain	strain	NN
cord-282246-wyanwvxa	98	25	-	-	HYPH
cord-282246-wyanwvxa	98	26	dependent	dependent	JJ
cord-282246-wyanwvxa	98	27	manner	manner	NN
cord-282246-wyanwvxa	98	28	[	[	-LRB-
cord-282246-wyanwvxa	98	29	42	42	CD
cord-282246-wyanwvxa	98	30	,	,	,
cord-282246-wyanwvxa	98	31	60	60	CD
cord-282246-wyanwvxa	98	32	]	]	-RRB-
cord-282246-wyanwvxa	98	33	.	.	.
cord-282246-wyanwvxa	99	1	This	this	DT
cord-282246-wyanwvxa	99	2	process	process	NN
cord-282246-wyanwvxa	99	3	takes	take	VBZ
cord-282246-wyanwvxa	99	4	place	place	NN
cord-282246-wyanwvxa	99	5	first	first	RB
cord-282246-wyanwvxa	99	6	through	through	IN
cord-282246-wyanwvxa	99	7	the	the	DT
cord-282246-wyanwvxa	99	8	recognition	recognition	NN
cord-282246-wyanwvxa	99	9	of	of	IN
cord-282246-wyanwvxa	99	10	IRF3	IRF3	NNP
cord-282246-wyanwvxa	99	11	using	use	VBG
cord-282246-wyanwvxa	99	12	an	an	DT
cord-282246-wyanwvxa	99	13	ELLIS	ELLIS	NNP
cord-282246-wyanwvxa	99	14	motif	motif	NN
cord-282246-wyanwvxa	99	15	localized	localize	VBN
cord-282246-wyanwvxa	99	16	at	at	IN
cord-282246-wyanwvxa	99	17	the	the	DT
cord-282246-wyanwvxa	99	18	C	C	NNP
cord-282246-wyanwvxa	99	19	-	-	HYPH
cord-282246-wyanwvxa	99	20	terminal	terminal	NN
cord-282246-wyanwvxa	99	21	end	end	NN
cord-282246-wyanwvxa	99	22	of	of	IN
cord-282246-wyanwvxa	99	23	NSP1	NSP1	NNP
cord-282246-wyanwvxa	99	24	present	present	NN
cord-282246-wyanwvxa	99	25	on	on	IN
cord-282246-wyanwvxa	99	26	the	the	DT
cord-282246-wyanwvxa	99	27	NSP1	NSP1	NNP
cord-282246-wyanwvxa	99	28	molecule	molecule	NN
cord-282246-wyanwvxa	99	29	derived	derive	VBN
cord-282246-wyanwvxa	99	30	from	from	IN
cord-282246-wyanwvxa	99	31	simian	simian	JJ
cord-282246-wyanwvxa	99	32	,	,	,
cord-282246-wyanwvxa	99	33	murine	murine	JJ
cord-282246-wyanwvxa	99	34	,	,	,
cord-282246-wyanwvxa	99	35	and	and	CC
cord-282246-wyanwvxa	99	36	some	some	DT
cord-282246-wyanwvxa	99	37	other	other	JJ
cord-282246-wyanwvxa	99	38	nonhuman	nonhuman	NN
cord-282246-wyanwvxa	99	39	RV	rv	NN
cord-282246-wyanwvxa	99	40	strains	strain	NNS
cord-282246-wyanwvxa	99	41	[	[	-LRB-
cord-282246-wyanwvxa	99	42	61	61	CD
cord-282246-wyanwvxa	99	43	]	]	-RRB-
cord-282246-wyanwvxa	99	44	.	.	.
cord-282246-wyanwvxa	100	1	The	the	DT
cord-282246-wyanwvxa	100	2	NSP1ÀIRF3	NSP1ÀIRF3	NNP
cord-282246-wyanwvxa	100	3	interaction	interaction	NN
cord-282246-wyanwvxa	100	4	subsequently	subsequently	RB
cord-282246-wyanwvxa	100	5	results	result	VBZ
cord-282246-wyanwvxa	100	6	in	in	IN
cord-282246-wyanwvxa	100	7	a	a	DT
cord-282246-wyanwvxa	100	8	rapid	rapid	JJ
cord-282246-wyanwvxa	100	9	and	and	CC
cord-282246-wyanwvxa	100	10	efficient	efficient	JJ
cord-282246-wyanwvxa	100	11	degradation	degradation	NN
cord-282246-wyanwvxa	100	12	of	of	IN
cord-282246-wyanwvxa	100	13	IRF3	IRF3	NNP
cord-282246-wyanwvxa	100	14	at	at	IN
cord-282246-wyanwvxa	100	15	the	the	DT
cord-282246-wyanwvxa	100	16	proteasome	proteasome	NN
cord-282246-wyanwvxa	100	17	and	and	CC
cord-282246-wyanwvxa	100	18	suppression	suppression	NN
cord-282246-wyanwvxa	100	19	of	of	IN
cord-282246-wyanwvxa	100	20	IFN	IFN	NNP
cord-282246-wyanwvxa	100	21	production	production	NN
cord-282246-wyanwvxa	100	22	in	in	IN
cord-282246-wyanwvxa	100	23	RV	rv	NN
cord-282246-wyanwvxa	100	24	-	-	HYPH
cord-282246-wyanwvxa	100	25	infected	infect	VBN
cord-282246-wyanwvxa	100	26	cells	cell	NNS
cord-282246-wyanwvxa	100	27	(	(	-LRB-
cord-282246-wyanwvxa	100	28	Fig	fig	NN
cord-282246-wyanwvxa	100	29	.	.	.
cord-282246-wyanwvxa	100	30	40.2	40.2	CD
cord-282246-wyanwvxa	100	31	)	)	-RRB-
cord-282246-wyanwvxa	100	32	.	.	.
cord-282246-wyanwvxa	101	1	Besides	besides	IN
cord-282246-wyanwvxa	101	2	the	the	DT
cord-282246-wyanwvxa	101	3	IRF	IRF	NNP
cord-282246-wyanwvxa	101	4	family	family	NN
cord-282246-wyanwvxa	101	5	members	member	NNS
cord-282246-wyanwvxa	101	6	,	,	,
cord-282246-wyanwvxa	101	7	NF	NF	NNP
cord-282246-wyanwvxa	101	8	-	-	HYPH
cord-282246-wyanwvxa	101	9	κB	κB	NNP
cord-282246-wyanwvxa	101	10	has	have	VBZ
cord-282246-wyanwvxa	101	11	been	be	VBN
cord-282246-wyanwvxa	101	12	shown	show	VBN
cord-282246-wyanwvxa	101	13	to	to	TO
cord-282246-wyanwvxa	101	14	be	be	VB
cord-282246-wyanwvxa	101	15	another	another	DT
cord-282246-wyanwvxa	101	16	key	key	JJ
cord-282246-wyanwvxa	101	17	arm	arm	NN
cord-282246-wyanwvxa	101	18	of	of	IN
cord-282246-wyanwvxa	101	19	the	the	DT
cord-282246-wyanwvxa	101	20	host	host	NN
cord-282246-wyanwvxa	101	21	innate	innate	JJ
cord-282246-wyanwvxa	101	22	immune	immune	JJ
cord-282246-wyanwvxa	101	23	response	response	NN
cord-282246-wyanwvxa	101	24	downstream	downstream	RB
cord-282246-wyanwvxa	101	25	of	of	IN
cord-282246-wyanwvxa	101	26	MAVS	MAVS	NNPS
cord-282246-wyanwvxa	101	27	in	in	IN
cord-282246-wyanwvxa	101	28	many	many	JJ
cord-282246-wyanwvxa	101	29	virus	virus	NN
cord-282246-wyanwvxa	101	30	-	-	HYPH
cord-282246-wyanwvxa	101	31	infected	infect	VBN
cord-282246-wyanwvxa	101	32	cells	cell	NNS
cord-282246-wyanwvxa	101	33	[	[	-LRB-
cord-282246-wyanwvxa	101	34	56	56	CD
cord-282246-wyanwvxa	101	35	]	]	-RRB-
cord-282246-wyanwvxa	101	36	.	.	.
cord-282246-wyanwvxa	102	1	NF	NF	NNP
cord-282246-wyanwvxa	102	2	-	-	HYPH
cord-282246-wyanwvxa	102	3	κB	κB	NNP
cord-282246-wyanwvxa	102	4	signaling	signaling	NN
cord-282246-wyanwvxa	102	5	is	be	VBZ
cord-282246-wyanwvxa	102	6	robustly	robustly	RB
cord-282246-wyanwvxa	102	7	activated	activate	VBN
cord-282246-wyanwvxa	102	8	by	by	IN
cord-282246-wyanwvxa	102	9	virus	virus	NN
cord-282246-wyanwvxa	102	10	infection	infection	NN
cord-282246-wyanwvxa	102	11	as	as	RB
cord-282246-wyanwvxa	102	12	well	well	RB
cord-282246-wyanwvxa	102	13	as	as	IN
cord-282246-wyanwvxa	102	14	proinflammatory	proinflammatory	JJ
cord-282246-wyanwvxa	102	15	cytokines	cytokine	NNS
cord-282246-wyanwvxa	102	16	,	,	,
cord-282246-wyanwvxa	102	17	including	include	VBG
cord-282246-wyanwvxa	102	18	IL-1β	IL-1β	NNP
cord-282246-wyanwvxa	102	19	and	and	CC
cord-282246-wyanwvxa	102	20	TNF	TNF	NNP
cord-282246-wyanwvxa	102	21	-	-	HYPH
cord-282246-wyanwvxa	102	22	α	α	NNP
cord-282246-wyanwvxa	102	23	,	,	,
cord-282246-wyanwvxa	102	24	the	the	DT
cord-282246-wyanwvxa	102	25	latter	latter	JJ
cord-282246-wyanwvxa	102	26	of	of	IN
cord-282246-wyanwvxa	102	27	which	which	WDT
cord-282246-wyanwvxa	102	28	has	have	VBZ
cord-282246-wyanwvxa	102	29	recently	recently	RB
cord-282246-wyanwvxa	102	30	been	be	VBN
cord-282246-wyanwvxa	102	31	shown	show	VBN
cord-282246-wyanwvxa	102	32	to	to	TO
cord-282246-wyanwvxa	102	33	be	be	VB
cord-282246-wyanwvxa	102	34	directly	directly	RB
cord-282246-wyanwvxa	102	35	antiviral	antiviral	JJ
cord-282246-wyanwvxa	102	36	against	against	IN
cord-282246-wyanwvxa	102	37	RV	RV	NNP
cord-282246-wyanwvxa	102	38	[	[	-LRB-
cord-282246-wyanwvxa	102	39	62	62	CD
cord-282246-wyanwvxa	102	40	]	]	-RRB-
cord-282246-wyanwvxa	102	41	.	.	.
cord-282246-wyanwvxa	103	1	For	for	IN
cord-282246-wyanwvxa	103	2	RV	rv	NN
cord-282246-wyanwvxa	103	3	infection	infection	NN
cord-282246-wyanwvxa	103	4	of	of	IN
cord-282246-wyanwvxa	103	5	HT-29	HT-29	NNP
cord-282246-wyanwvxa	103	6	cells	cell	NNS
cord-282246-wyanwvxa	103	7	,	,	,
cord-282246-wyanwvxa	103	8	the	the	DT
cord-282246-wyanwvxa	103	9	secretion	secretion	NN
cord-282246-wyanwvxa	103	10	of	of	IN
cord-282246-wyanwvxa	103	11	IL-8	IL-8	NNP
cord-282246-wyanwvxa	103	12	is	be	VBZ
cord-282246-wyanwvxa	103	13	dependent	dependent	JJ
cord-282246-wyanwvxa	103	14	on	on	IN
cord-282246-wyanwvxa	103	15	the	the	DT
cord-282246-wyanwvxa	103	16	NF	nf	NN
cord-282246-wyanwvxa	103	17	-	-	HYPH
cord-282246-wyanwvxa	103	18	κB	κb	CD
cord-282246-wyanwvxa	103	19	activation	activation	NN
cord-282246-wyanwvxa	103	20	[	[	-LRB-
cord-282246-wyanwvxa	103	21	63	63	CD
cord-282246-wyanwvxa	103	22	]	]	-RRB-
cord-282246-wyanwvxa	103	23	.	.	.
cord-282246-wyanwvxa	104	1	In	in	IN
cord-282246-wyanwvxa	104	2	a	a	DT
cord-282246-wyanwvxa	104	3	suckling	suckle	VBG
cord-282246-wyanwvxa	104	4	mouse	mouse	NN
cord-282246-wyanwvxa	104	5	model	model	NN
cord-282246-wyanwvxa	104	6	,	,	,
cord-282246-wyanwvxa	104	7	other	other	JJ
cord-282246-wyanwvxa	104	8	chemokines	chemokine	NNS
cord-282246-wyanwvxa	104	9	such	such	JJ
cord-282246-wyanwvxa	104	10	as	as	IN
cord-282246-wyanwvxa	104	11	CCL3	CCL3	NNP
cord-282246-wyanwvxa	104	12	,	,	,
cord-282246-wyanwvxa	104	13	CCL5	CCL5	NNP
cord-282246-wyanwvxa	104	14	,	,	,
cord-282246-wyanwvxa	104	15	CXCL10	CXCL10	NNP
cord-282246-wyanwvxa	104	16	,	,	,
cord-282246-wyanwvxa	104	17	and	and	CC
cord-282246-wyanwvxa	104	18	GM	GM	NNP
cord-282246-wyanwvxa	104	19	-	-	HYPH
cord-282246-wyanwvxa	104	20	CSF	CSF	NNP
cord-282246-wyanwvxa	104	21	were	be	VBD
cord-282246-wyanwvxa	104	22	also	also	RB
cord-282246-wyanwvxa	104	23	upregulated	upregulate	VBN
cord-282246-wyanwvxa	104	24	following	follow	VBG
cord-282246-wyanwvxa	104	25	RV	rv	NN
cord-282246-wyanwvxa	104	26	infection	infection	NN
cord-282246-wyanwvxa	104	27	[	[	-LRB-
cord-282246-wyanwvxa	104	28	64	64	CD
cord-282246-wyanwvxa	104	29	]	]	-RRB-
cord-282246-wyanwvxa	104	30	,	,	,
cord-282246-wyanwvxa	104	31	although	although	IN
cord-282246-wyanwvxa	104	32	whether	whether	IN
cord-282246-wyanwvxa	104	33	these	these	DT
cord-282246-wyanwvxa	104	34	canonical	canonical	JJ
cord-282246-wyanwvxa	104	35	NF	nf	NN
cord-282246-wyanwvxa	104	36	-	-	HYPH
cord-282246-wyanwvxa	104	37	κB	κb	CD
cord-282246-wyanwvxa	104	38	cytokines	cytokine	NNS
cord-282246-wyanwvxa	104	39	are	be	VBP
cord-282246-wyanwvxa	104	40	activated	activate	VBN
cord-282246-wyanwvxa	104	41	through	through	IN
cord-282246-wyanwvxa	104	42	MAVS	MAVS	NNPS
cord-282246-wyanwvxa	104	43	or	or	CC
cord-282246-wyanwvxa	104	44	TLRs	TLRs	NNP
cord-282246-wyanwvxa	104	45	remains	remain	VBZ
cord-282246-wyanwvxa	104	46	unknown	unknown	JJ
cord-282246-wyanwvxa	104	47	.	.	.
cord-282246-wyanwvxa	105	1	Similar	similar	JJ
cord-282246-wyanwvxa	105	2	to	to	IN
cord-282246-wyanwvxa	105	3	IRF3	IRF3	NNP
cord-282246-wyanwvxa	105	4	,	,	,
cord-282246-wyanwvxa	105	5	β	β	NN
cord-282246-wyanwvxa	105	6	-	-	HYPH
cord-282246-wyanwvxa	105	7	TrCP	TrCP	NNP
cord-282246-wyanwvxa	105	8	,	,	,
cord-282246-wyanwvxa	105	9	a	a	DT
cord-282246-wyanwvxa	105	10	critical	critical	JJ
cord-282246-wyanwvxa	105	11	protein	protein	NN
cord-282246-wyanwvxa	105	12	essential	essential	JJ
cord-282246-wyanwvxa	105	13	for	for	IN
cord-282246-wyanwvxa	105	14	degrading	degrade	VBG
cord-282246-wyanwvxa	105	15	cellular	cellular	JJ
cord-282246-wyanwvxa	105	16	NF	nf	NN
cord-282246-wyanwvxa	105	17	-	-	HYPH
cord-282246-wyanwvxa	105	18	κB	κb	CD
cord-282246-wyanwvxa	105	19	inhibitor	inhibitor	NN
cord-282246-wyanwvxa	105	20	IκB	iκb	NN
cord-282246-wyanwvxa	105	21	,	,	,
cord-282246-wyanwvxa	105	22	is	be	VBZ
cord-282246-wyanwvxa	105	23	also	also	RB
cord-282246-wyanwvxa	105	24	targeted	target	VBN
cord-282246-wyanwvxa	105	25	by	by	IN
cord-282246-wyanwvxa	105	26	NSP1	NSP1	NNP
cord-282246-wyanwvxa	105	27	for	for	IN
cord-282246-wyanwvxa	105	28	proteasomal	proteasomal	JJ
cord-282246-wyanwvxa	105	29	degradation	degradation	NN
cord-282246-wyanwvxa	105	30	[	[	-LRB-
cord-282246-wyanwvxa	105	31	45	45	CD
cord-282246-wyanwvxa	105	32	]	]	-RRB-
cord-282246-wyanwvxa	105	33	.	.	.
cord-282246-wyanwvxa	106	1	In	in	IN
cord-282246-wyanwvxa	106	2	the	the	DT
cord-282246-wyanwvxa	106	3	case	case	NN
cord-282246-wyanwvxa	106	4	of	of	IN
cord-282246-wyanwvxa	106	5	β	β	NN
cord-282246-wyanwvxa	106	6	-	-	HYPH
cord-282246-wyanwvxa	106	7	TrCP	TrCP	NNP
cord-282246-wyanwvxa	106	8	,	,	,
cord-282246-wyanwvxa	106	9	the	the	DT
cord-282246-wyanwvxa	106	10	binding	bind	VBG
cord-282246-wyanwvxa	106	11	domain	domain	NN
cord-282246-wyanwvxa	106	12	within	within	IN
cord-282246-wyanwvxa	106	13	NSP1	NSP1	NNP
cord-282246-wyanwvxa	106	14	maps	map	NNS
cord-282246-wyanwvxa	106	15	to	to	IN
cord-282246-wyanwvxa	106	16	a	a	DT
cord-282246-wyanwvxa	106	17	C	c	NN
cord-282246-wyanwvxa	106	18	-	-	HYPH
cord-282246-wyanwvxa	106	19	terminal	terminal	NN
cord-282246-wyanwvxa	106	20	DSGIS	DSGIS	NNP
cord-282246-wyanwvxa	106	21	motif	motif	NN
cord-282246-wyanwvxa	106	22	in	in	IN
cord-282246-wyanwvxa	106	23	human	human	JJ
cord-282246-wyanwvxa	106	24	and	and	CC
cord-282246-wyanwvxa	106	25	porcine	porcine	JJ
cord-282246-wyanwvxa	106	26	RV	rv	NN
cord-282246-wyanwvxa	106	27	strains	strain	NNS
cord-282246-wyanwvxa	106	28	[	[	-LRB-
cord-282246-wyanwvxa	106	29	65	65	CD
cord-282246-wyanwvxa	106	30	]	]	-RRB-
cord-282246-wyanwvxa	106	31	.	.	.
cord-282246-wyanwvxa	107	1	Importantly	importantly	RB
cord-282246-wyanwvxa	107	2	,	,	,
cord-282246-wyanwvxa	107	3	this	this	DT
cord-282246-wyanwvxa	107	4	is	be	VBZ
cord-282246-wyanwvxa	107	5	the	the	DT
cord-282246-wyanwvxa	107	6	same	same	JJ
cord-282246-wyanwvxa	107	7	region	region	NN
cord-282246-wyanwvxa	107	8	as	as	IN
cord-282246-wyanwvxa	107	9	the	the	DT
cord-282246-wyanwvxa	107	10	ELLIS	ELLIS	NNP
cord-282246-wyanwvxa	107	11	motif	motif	NN
cord-282246-wyanwvxa	107	12	responsible	responsible	JJ
cord-282246-wyanwvxa	107	13	for	for	IN
cord-282246-wyanwvxa	107	14	IRF3	IRF3	NNP
cord-282246-wyanwvxa	107	15	binding	binding	NN
cord-282246-wyanwvxa	107	16	mentioned	mention	VBN
cord-282246-wyanwvxa	107	17	above	above	RB
cord-282246-wyanwvxa	107	18	.	.	.
cord-282246-wyanwvxa	108	1	This	this	DT
cord-282246-wyanwvxa	108	2	interesting	interesting	JJ
cord-282246-wyanwvxa	108	3	dichotomy	dichotomy	NN
cord-282246-wyanwvxa	108	4	of	of	IN
cord-282246-wyanwvxa	108	5	NSP1Àsubstrate	NSP1Àsubstrate	NNP
cord-282246-wyanwvxa	108	6	interaction	interaction	NN
cord-282246-wyanwvxa	108	7	may	may	MD
cord-282246-wyanwvxa	108	8	stem	stem	VB
cord-282246-wyanwvxa	108	9	from	from	IN
cord-282246-wyanwvxa	108	10	the	the	DT
cord-282246-wyanwvxa	108	11	distinct	distinct	JJ
cord-282246-wyanwvxa	108	12	contribution	contribution	NN
cord-282246-wyanwvxa	108	13	of	of	IN
cord-282246-wyanwvxa	108	14	IRF3	IRF3	NNP
cord-282246-wyanwvxa	108	15	versus	versus	IN
cord-282246-wyanwvxa	108	16	β	β	NN
cord-282246-wyanwvxa	108	17	-	-	HYPH
cord-282246-wyanwvxa	108	18	TrCP	trcp	NN
cord-282246-wyanwvxa	108	19	in	in	IN
cord-282246-wyanwvxa	108	20	IFN	IFN	NNP
cord-282246-wyanwvxa	108	21	induction	induction	NN
cord-282246-wyanwvxa	108	22	in	in	IN
cord-282246-wyanwvxa	108	23	different	different	JJ
cord-282246-wyanwvxa	108	24	human	human	NN
cord-282246-wyanwvxa	108	25	and	and	CC
cord-282246-wyanwvxa	108	26	animal	animal	NN
cord-282246-wyanwvxa	108	27	RV	rv	NN
cord-282246-wyanwvxa	108	28	species	specie	NNS
cord-282246-wyanwvxa	108	29	[	[	-LRB-
cord-282246-wyanwvxa	108	30	45	45	CD
cord-282246-wyanwvxa	108	31	]	]	-RRB-
cord-282246-wyanwvxa	108	32	.	.	.
cord-282246-wyanwvxa	109	1	In	in	IN
cord-282246-wyanwvxa	109	2	contrast	contrast	NN
cord-282246-wyanwvxa	109	3	to	to	IN
cord-282246-wyanwvxa	109	4	the	the	DT
cord-282246-wyanwvxa	109	5	previous	previous	JJ
cord-282246-wyanwvxa	109	6	speculation	speculation	NN
cord-282246-wyanwvxa	109	7	of	of	IN
cord-282246-wyanwvxa	109	8	NSP1	NSP1	NNP
cord-282246-wyanwvxa	109	9	as	as	IN
cord-282246-wyanwvxa	109	10	a	a	DT
cord-282246-wyanwvxa	109	11	viral	viral	JJ
cord-282246-wyanwvxa	109	12	E3	e3	NN
cord-282246-wyanwvxa	109	13	ligase	ligase	NN
cord-282246-wyanwvxa	109	14	due	due	IN
cord-282246-wyanwvxa	109	15	to	to	IN
cord-282246-wyanwvxa	109	16	the	the	DT
cord-282246-wyanwvxa	109	17	presence	presence	NN
cord-282246-wyanwvxa	109	18	of	of	IN
cord-282246-wyanwvxa	109	19	an	an	DT
cord-282246-wyanwvxa	109	20	N	n	CD
cord-282246-wyanwvxa	109	21	-	-	HYPH
cord-282246-wyanwvxa	109	22	terminal	terminal	NN
cord-282246-wyanwvxa	109	23	RING	ring	NN
cord-282246-wyanwvxa	109	24	finger	finger	NN
cord-282246-wyanwvxa	109	25	domain	domain	NN
cord-282246-wyanwvxa	109	26	,	,	,
cord-282246-wyanwvxa	109	27	we	-PRON-	PRP
cord-282246-wyanwvxa	109	28	recently	recently	RB
cord-282246-wyanwvxa	109	29	discovered	discover	VBD
cord-282246-wyanwvxa	109	30	an	an	DT
cord-282246-wyanwvxa	109	31	interesting	interesting	JJ
cord-282246-wyanwvxa	109	32	codestruction	codestruction	NN
cord-282246-wyanwvxa	109	33	mechanism	mechanism	NN
cord-282246-wyanwvxa	109	34	,	,	,
cord-282246-wyanwvxa	109	35	in	in	IN
cord-282246-wyanwvxa	109	36	which	which	WDT
cord-282246-wyanwvxa	109	37	NSP1	NSP1	NNP
cord-282246-wyanwvxa	109	38	localizes	localize	VBZ
cord-282246-wyanwvxa	109	39	to	to	IN
cord-282246-wyanwvxa	109	40	the	the	DT
cord-282246-wyanwvxa	109	41	Golgi	Golgi	NNP
cord-282246-wyanwvxa	109	42	apparatus	apparatus	NN
cord-282246-wyanwvxa	109	43	and	and	CC
cord-282246-wyanwvxa	109	44	hijacks	hijack	VBZ
cord-282246-wyanwvxa	109	45	the	the	DT
cord-282246-wyanwvxa	109	46	host	host	NN
cord-282246-wyanwvxa	110	1	cullin	cullin	NNP
cord-282246-wyanwvxa	110	2	3ÀRING	3àring	CD
cord-282246-wyanwvxa	110	3	box	box	NNP
cord-282246-wyanwvxa	110	4	protein	protein	NN
cord-282246-wyanwvxa	110	5	1	1	CD
cord-282246-wyanwvxa	110	6	E3	E3	NNP
cord-282246-wyanwvxa	110	7	ligase	ligase	NN
cord-282246-wyanwvxa	110	8	complex	complex	NN
cord-282246-wyanwvxa	110	9	to	to	TO
cord-282246-wyanwvxa	110	10	induce	induce	VB
cord-282246-wyanwvxa	110	11	the	the	DT
cord-282246-wyanwvxa	110	12	proteasomal	proteasomal	JJ
cord-282246-wyanwvxa	110	13	degradation	degradation	NN
cord-282246-wyanwvxa	110	14	of	of	IN
cord-282246-wyanwvxa	110	15	both	both	CC
cord-282246-wyanwvxa	110	16	β	β	NN
cord-282246-wyanwvxa	110	17	-	-	HYPH
cord-282246-wyanwvxa	110	18	TrCP	TrCP	NNP
cord-282246-wyanwvxa	110	19	and	and	CC
cord-282246-wyanwvxa	110	20	NSP1	NSP1	NNP
cord-282246-wyanwvxa	110	21	itself	-PRON-	PRP
cord-282246-wyanwvxa	110	22	[	[	-LRB-
cord-282246-wyanwvxa	110	23	44	44	CD
cord-282246-wyanwvxa	110	24	]	]	-RRB-
cord-282246-wyanwvxa	110	25	.	.	.
cord-282246-wyanwvxa	111	1	Chemical	chemical	NN
cord-282246-wyanwvxa	111	2	blockade	blockade	NN
cord-282246-wyanwvxa	111	3	or	or	CC
cord-282246-wyanwvxa	111	4	siRNA	siRNA	NNP
cord-282246-wyanwvxa	111	5	knockdown	knockdown	NN
cord-282246-wyanwvxa	111	6	of	of	IN
cord-282246-wyanwvxa	111	7	cullin-3	cullin-3	NN
cord-282246-wyanwvxa	111	8	components	component	NNS
cord-282246-wyanwvxa	111	9	impaired	impair	VBD
cord-282246-wyanwvxa	111	10	NSP1	NSP1	NNP
cord-282246-wyanwvxa	111	11	's	's	POS
cord-282246-wyanwvxa	111	12	ability	ability	NN
cord-282246-wyanwvxa	111	13	to	to	TO
cord-282246-wyanwvxa	111	14	degrade	degrade	VB
cord-282246-wyanwvxa	111	15	β	β	NN
cord-282246-wyanwvxa	111	16	-	-	HYPH
cord-282246-wyanwvxa	111	17	TrCP	TrCP	NNP
cord-282246-wyanwvxa	111	18	,	,	,
cord-282246-wyanwvxa	111	19	leading	lead	VBG
cord-282246-wyanwvxa	111	20	to	to	IN
cord-282246-wyanwvxa	111	21	a	a	DT
cord-282246-wyanwvxa	111	22	significant	significant	JJ
cord-282246-wyanwvxa	111	23	increase	increase	NN
cord-282246-wyanwvxa	111	24	in	in	IN
cord-282246-wyanwvxa	111	25	the	the	DT
cord-282246-wyanwvxa	111	26	levels	level	NNS
cord-282246-wyanwvxa	111	27	of	of	IN
cord-282246-wyanwvxa	111	28	β	β	NN
cord-282246-wyanwvxa	111	29	-	-	HYPH
cord-282246-wyanwvxa	111	30	TrCP	trcp	NN
cord-282246-wyanwvxa	111	31	and	and	CC
cord-282246-wyanwvxa	111	32	reduced	reduce	VBN
cord-282246-wyanwvxa	111	33	RV	rv	NN
cord-282246-wyanwvxa	111	34	replication	replication	NN
cord-282246-wyanwvxa	111	35	(	(	-LRB-
cord-282246-wyanwvxa	111	36	Fig	fig	NN
cord-282246-wyanwvxa	111	37	.	.	.
cord-282246-wyanwvxa	111	38	40.2	40.2	CD
cord-282246-wyanwvxa	111	39	)	)	-RRB-
cord-282246-wyanwvxa	111	40	.	.	.
cord-282246-wyanwvxa	112	1	Interestingly	interestingly	RB
cord-282246-wyanwvxa	112	2	,	,	,
cord-282246-wyanwvxa	112	3	the	the	DT
cord-282246-wyanwvxa	112	4	cullin	cullin	NNP
cord-282246-wyanwvxa	112	5	complex	complex	NN
cord-282246-wyanwvxa	112	6	did	do	VBD
cord-282246-wyanwvxa	112	7	not	not	RB
cord-282246-wyanwvxa	112	8	appear	appear	VB
cord-282246-wyanwvxa	112	9	to	to	TO
cord-282246-wyanwvxa	112	10	be	be	VB
cord-282246-wyanwvxa	112	11	required	require	VBN
cord-282246-wyanwvxa	112	12	for	for	IN
cord-282246-wyanwvxa	112	13	NSP1-mediated	NSP1-mediated	NNP
cord-282246-wyanwvxa	112	14	IRF3	IRF3	NNP
cord-282246-wyanwvxa	112	15	degradation	degradation	NN
cord-282246-wyanwvxa	112	16	,	,	,
cord-282246-wyanwvxa	112	17	suggesting	suggest	VBG
cord-282246-wyanwvxa	112	18	an	an	DT
cord-282246-wyanwvxa	112	19	alternative	alternative	JJ
cord-282246-wyanwvxa	112	20	mechanism	mechanism	NN
cord-282246-wyanwvxa	112	21	of	of	IN
cord-282246-wyanwvxa	112	22	action	action	NN
cord-282246-wyanwvxa	112	23	at	at	IN
cord-282246-wyanwvxa	112	24	work	work	NN
cord-282246-wyanwvxa	112	25	.	.	.
cord-282246-wyanwvxa	113	1	More	more	RBR
cord-282246-wyanwvxa	113	2	recent	recent	JJ
cord-282246-wyanwvxa	113	3	unpublished	unpublished	JJ
cord-282246-wyanwvxa	113	4	data	datum	NNS
cord-282246-wyanwvxa	113	5	from	from	IN
cord-282246-wyanwvxa	113	6	our	-PRON-	PRP$
cord-282246-wyanwvxa	113	7	lab	lab	NN
cord-282246-wyanwvxa	113	8	indicate	indicate	VBP
cord-282246-wyanwvxa	113	9	that	that	IN
cord-282246-wyanwvxa	113	10	in	in	IN
cord-282246-wyanwvxa	113	11	addition	addition	NN
cord-282246-wyanwvxa	113	12	to	to	IN
cord-282246-wyanwvxa	113	13	IRFs	irfs	NN
cord-282246-wyanwvxa	113	14	and	and	CC
cord-282246-wyanwvxa	113	15	β	β	NN
cord-282246-wyanwvxa	113	16	-	-	HYPH
cord-282246-wyanwvxa	113	17	TrCP	TrCP	NNP
cord-282246-wyanwvxa	113	18	,	,	,
cord-282246-wyanwvxa	113	19	MAVS	MAVS	NNP
cord-282246-wyanwvxa	113	20	itself	-PRON-	PRP
cord-282246-wyanwvxa	113	21	is	be	VBZ
cord-282246-wyanwvxa	113	22	also	also	RB
cord-282246-wyanwvxa	113	23	subject	subject	JJ
cord-282246-wyanwvxa	113	24	to	to	IN
cord-282246-wyanwvxa	113	25	RV	RV	NNP
cord-282246-wyanwvxa	113	26	inhibition	inhibition	NN
cord-282246-wyanwvxa	113	27	.	.	.
cord-282246-wyanwvxa	114	1	MAVS	MAVS	NNP
cord-282246-wyanwvxa	114	2	levels	level	NNS
cord-282246-wyanwvxa	114	3	were	be	VBD
cord-282246-wyanwvxa	114	4	significantly	significantly	RB
cord-282246-wyanwvxa	114	5	reduced	reduce	VBN
cord-282246-wyanwvxa	114	6	during	during	IN
cord-282246-wyanwvxa	114	7	RV	RV	NNP
cord-282246-wyanwvxa	114	8	infection	infection	NN
cord-282246-wyanwvxa	114	9	,	,	,
cord-282246-wyanwvxa	114	10	and	and	CC
cord-282246-wyanwvxa	114	11	this	this	DT
cord-282246-wyanwvxa	114	12	process	process	NN
cord-282246-wyanwvxa	114	13	is	be	VBZ
cord-282246-wyanwvxa	114	14	mediated	mediate	VBN
cord-282246-wyanwvxa	114	15	,	,	,
cord-282246-wyanwvxa	114	16	surprisingly	surprisingly	RB
cord-282246-wyanwvxa	114	17	,	,	,
cord-282246-wyanwvxa	114	18	by	by	IN
cord-282246-wyanwvxa	114	19	the	the	DT
cord-282246-wyanwvxa	114	20	RNA	RNA	NNP
cord-282246-wyanwvxa	114	21	methyl	methyl	NN
cord-282246-wyanwvxa	114	22	-	-	:
cord-282246-wyanwvxa	114	23	and	and	CC
cord-282246-wyanwvxa	114	24	guanylyltransferase	guanylyltransferase	NNP
cord-282246-wyanwvxa	114	25	VP3	VP3	NNP
cord-282246-wyanwvxa	114	26	protein	protein	NN
cord-282246-wyanwvxa	114	27	(	(	-LRB-
cord-282246-wyanwvxa	114	28	Fig	Fig	NNP
cord-282246-wyanwvxa	114	29	.	.	.
cord-282246-wyanwvxa	114	30	40.2	40.2	CD
cord-282246-wyanwvxa	114	31	)	)	-RRB-
cord-282246-wyanwvxa	114	32	.	.	.
cord-282246-wyanwvxa	115	1	By	by	IN
cord-282246-wyanwvxa	115	2	localizing	localize	VBG
cord-282246-wyanwvxa	115	3	to	to	IN
cord-282246-wyanwvxa	115	4	the	the	DT
cord-282246-wyanwvxa	115	5	mitochondria	mitochondrion	NNS
cord-282246-wyanwvxa	115	6	and	and	CC
cord-282246-wyanwvxa	115	7	binding	bind	VBG
cord-282246-wyanwvxa	115	8	to	to	IN
cord-282246-wyanwvxa	115	9	MAVS	MAVS	NNP
cord-282246-wyanwvxa	115	10	through	through	IN
cord-282246-wyanwvxa	115	11	an	an	DT
cord-282246-wyanwvxa	115	12	N	n	CD
cord-282246-wyanwvxa	115	13	-	-	HYPH
cord-282246-wyanwvxa	115	14	terminal	terminal	NN
cord-282246-wyanwvxa	115	15	domain	domain	NN
cord-282246-wyanwvxa	115	16	,	,	,
cord-282246-wyanwvxa	115	17	VP3	VP3	NNP
cord-282246-wyanwvxa	115	18	induced	induce	VBN
cord-282246-wyanwvxa	115	19	efficiently	efficiently	RB
cord-282246-wyanwvxa	115	20	proteasomal	proteasomal	JJ
cord-282246-wyanwvxa	115	21	degradation	degradation	NN
cord-282246-wyanwvxa	115	22	of	of	IN
cord-282246-wyanwvxa	115	23	MAVS	MAVS	NNPS
cord-282246-wyanwvxa	115	24	in	in	IN
cord-282246-wyanwvxa	115	25	a	a	DT
cord-282246-wyanwvxa	115	26	host	host	NN
cord-282246-wyanwvxa	115	27	-	-	HYPH
cord-282246-wyanwvxa	115	28	species	species	NN
cord-282246-wyanwvxa	115	29	-	-	HYPH
cord-282246-wyanwvxa	115	30	and	and	CC
cord-282246-wyanwvxa	115	31	virus	virus	NN
cord-282246-wyanwvxa	115	32	-	-	HYPH
cord-282246-wyanwvxa	115	33	strain	strain	NN
cord-282246-wyanwvxa	115	34	-	-	HYPH
cord-282246-wyanwvxa	115	35	specific	specific	JJ
cord-282246-wyanwvxa	115	36	manner	manner	NN
cord-282246-wyanwvxa	115	37	.	.	.
cord-282246-wyanwvxa	116	1	MAVS	MAVS	NNP
cord-282246-wyanwvxa	116	2	inhibition	inhibition	NN
cord-282246-wyanwvxa	116	3	by	by	IN
cord-282246-wyanwvxa	116	4	VP3	VP3	NNP
cord-282246-wyanwvxa	116	5	is	be	VBZ
cord-282246-wyanwvxa	116	6	another	another	DT
cord-282246-wyanwvxa	116	7	striking	striking	JJ
cord-282246-wyanwvxa	116	8	manifestation	manifestation	NN
cord-282246-wyanwvxa	116	9	of	of	IN
cord-282246-wyanwvxa	116	10	RV	RV	NNP
cord-282246-wyanwvxa	116	11	's	's	POS
cord-282246-wyanwvxa	116	12	ability	ability	NN
cord-282246-wyanwvxa	116	13	to	to	TO
cord-282246-wyanwvxa	116	14	subvert	subvert	VB
cord-282246-wyanwvxa	116	15	host	host	NN
cord-282246-wyanwvxa	116	16	innate	innate	JJ
cord-282246-wyanwvxa	116	17	immune	immune	JJ
cord-282246-wyanwvxa	116	18	signaling	signaling	NN
cord-282246-wyanwvxa	116	19	.	.	.
cord-282246-wyanwvxa	117	1	This	this	DT
cord-282246-wyanwvxa	117	2	is	be	VBZ
cord-282246-wyanwvxa	117	3	the	the	DT
cord-282246-wyanwvxa	117	4	first	first	JJ
cord-282246-wyanwvxa	117	5	example	example	NN
cord-282246-wyanwvxa	117	6	of	of	IN
cord-282246-wyanwvxa	117	7	MAVS	MAVS	NNP
cord-282246-wyanwvxa	117	8	degradation	degradation	NN
cord-282246-wyanwvxa	117	9	by	by	IN
cord-282246-wyanwvxa	117	10	an	an	DT
cord-282246-wyanwvxa	117	11	enteric	enteric	JJ
cord-282246-wyanwvxa	117	12	virus	virus	NN
cord-282246-wyanwvxa	117	13	,	,	,
cord-282246-wyanwvxa	117	14	and	and	CC
cord-282246-wyanwvxa	117	15	it	-PRON-	PRP
cord-282246-wyanwvxa	117	16	would	would	MD
cord-282246-wyanwvxa	117	17	be	be	VB
cord-282246-wyanwvxa	117	18	of	of	IN
cord-282246-wyanwvxa	117	19	interest	interest	NN
cord-282246-wyanwvxa	117	20	to	to	TO
cord-282246-wyanwvxa	117	21	further	further	JJ
cord-282246-wyanwvxa	117	22	test	test	VB
cord-282246-wyanwvxa	117	23	other	other	JJ
cord-282246-wyanwvxa	117	24	enteric	enteric	JJ
cord-282246-wyanwvxa	117	25	RNA	RNA	NNP
cord-282246-wyanwvxa	117	26	viruses	virus	NNS
cord-282246-wyanwvxa	117	27	such	such	JJ
cord-282246-wyanwvxa	117	28	as	as	IN
cord-282246-wyanwvxa	117	29	norovirus	norovirus	NN
cord-282246-wyanwvxa	117	30	.	.	.
cord-282246-wyanwvxa	118	1	The	the	DT
cord-282246-wyanwvxa	118	2	antiviral	antiviral	JJ
cord-282246-wyanwvxa	118	3	IFN	IFN	NNP
cord-282246-wyanwvxa	118	4	response	response	NN
cord-282246-wyanwvxa	118	5	to	to	IN
cord-282246-wyanwvxa	118	6	RV	RV	NNP
cord-282246-wyanwvxa	118	7	infection	infection	NN
cord-282246-wyanwvxa	118	8	follows	follow	VBZ
cord-282246-wyanwvxa	118	9	a	a	DT
cord-282246-wyanwvxa	118	10	biphasic	biphasic	JJ
cord-282246-wyanwvxa	118	11	pattern	pattern	NN
cord-282246-wyanwvxa	118	12	consisting	consist	VBG
cord-282246-wyanwvxa	118	13	of	of	IN
cord-282246-wyanwvxa	118	14	an	an	DT
cord-282246-wyanwvxa	118	15	pathway	pathway	NN
cord-282246-wyanwvxa	118	16	.	.	.
cord-282246-wyanwvxa	119	1	RV	RV	NNP
cord-282246-wyanwvxa	119	2	RNA	RNA	NNP
cord-282246-wyanwvxa	119	3	PAMP	PAMP	NNP
cord-282246-wyanwvxa	119	4	activates	activate	VBZ
cord-282246-wyanwvxa	119	5	the	the	DT
cord-282246-wyanwvxa	119	6	RNA	RNA	NNP
cord-282246-wyanwvxa	119	7	sensing	sensing	NN
cord-282246-wyanwvxa	119	8	pathway	pathway	NN
cord-282246-wyanwvxa	119	9	,	,	,
cord-282246-wyanwvxa	119	10	which	which	WDT
cord-282246-wyanwvxa	119	11	is	be	VBZ
cord-282246-wyanwvxa	119	12	antagonized	antagonize	VBN
cord-282246-wyanwvxa	119	13	by	by	IN
cord-282246-wyanwvxa	119	14	RV	rv	NN
cord-282246-wyanwvxa	119	15	-	-	HYPH
cord-282246-wyanwvxa	119	16	encoded	encode	VBN
cord-282246-wyanwvxa	119	17	proteins	protein	NNS
cord-282246-wyanwvxa	119	18	at	at	IN
cord-282246-wyanwvxa	119	19	multiple	multiple	JJ
cord-282246-wyanwvxa	119	20	steps	step	NNS
cord-282246-wyanwvxa	119	21	.	.	.
cord-282246-wyanwvxa	120	1	In	in	IN
cord-282246-wyanwvxa	120	2	unpublished	unpublished	JJ
cord-282246-wyanwvxa	120	3	studies	study	NNS
cord-282246-wyanwvxa	120	4	,	,	,
cord-282246-wyanwvxa	120	5	VP3	VP3	NNP
cord-282246-wyanwvxa	120	6	has	have	VBZ
cord-282246-wyanwvxa	120	7	been	be	VBN
cord-282246-wyanwvxa	120	8	shown	show	VBN
cord-282246-wyanwvxa	120	9	to	to	TO
cord-282246-wyanwvxa	120	10	directly	directly	RB
cord-282246-wyanwvxa	120	11	induce	induce	VB
cord-282246-wyanwvxa	120	12	the	the	DT
cord-282246-wyanwvxa	120	13	proteasomal	proteasomal	JJ
cord-282246-wyanwvxa	120	14	degradation	degradation	NN
cord-282246-wyanwvxa	120	15	of	of	IN
cord-282246-wyanwvxa	120	16	MAVS	MAVS	NNPS
cord-282246-wyanwvxa	120	17	.	.	.
cord-282246-wyanwvxa	121	1	In	in	IN
cord-282246-wyanwvxa	121	2	addition	addition	NN
cord-282246-wyanwvxa	121	3	,	,	,
cord-282246-wyanwvxa	121	4	NSP1	NSP1	NNP
cord-282246-wyanwvxa	121	5	from	from	IN
cord-282246-wyanwvxa	121	6	different	different	JJ
cord-282246-wyanwvxa	121	7	RV	rv	NN
cord-282246-wyanwvxa	121	8	strains	strain	NNS
cord-282246-wyanwvxa	121	9	degrades	degrade	VBZ
cord-282246-wyanwvxa	121	10	either	either	CC
cord-282246-wyanwvxa	121	11	IRF3	IRF3	NNP
cord-282246-wyanwvxa	121	12	or	or	CC
cord-282246-wyanwvxa	121	13	β	β	NN
cord-282246-wyanwvxa	121	14	-	-	HYPH
cord-282246-wyanwvxa	121	15	TrCP	TrCP	NNP
cord-282246-wyanwvxa	121	16	,	,	,
cord-282246-wyanwvxa	122	1	the	the	DT
cord-282246-wyanwvxa	122	2	latter	latter	JJ
cord-282246-wyanwvxa	122	3	of	of	IN
cord-282246-wyanwvxa	122	4	which	which	WDT
cord-282246-wyanwvxa	122	5	is	be	VBZ
cord-282246-wyanwvxa	122	6	mediated	mediate	VBN
cord-282246-wyanwvxa	122	7	by	by	IN
cord-282246-wyanwvxa	122	8	the	the	DT
cord-282246-wyanwvxa	122	9	host	host	NN
cord-282246-wyanwvxa	122	10	cullin	cullin	NNP
cord-282246-wyanwvxa	122	11	3ÀE3	3àe3	CD
cord-282246-wyanwvxa	122	12	ligase	ligase	NNP
cord-282246-wyanwvxa	122	13	complex	complex	JJ
cord-282246-wyanwvxa	122	14	.	.	.
cord-282246-wyanwvxa	123	1	Together	together	RB
cord-282246-wyanwvxa	123	2	,	,	,
cord-282246-wyanwvxa	123	3	these	these	DT
cord-282246-wyanwvxa	123	4	RV	rv	NN
cord-282246-wyanwvxa	123	5	proteins	protein	NNS
cord-282246-wyanwvxa	123	6	work	work	VBP
cord-282246-wyanwvxa	123	7	in	in	IN
cord-282246-wyanwvxa	123	8	concert	concert	NN
cord-282246-wyanwvxa	123	9	to	to	TO
cord-282246-wyanwvxa	123	10	dampen	dampen	VB
cord-282246-wyanwvxa	123	11	IFN	IFN	NNP
cord-282246-wyanwvxa	123	12	induction	induction	NN
cord-282246-wyanwvxa	123	13	in	in	IN
cord-282246-wyanwvxa	123	14	RV	rv	NN
cord-282246-wyanwvxa	123	15	-	-	HYPH
cord-282246-wyanwvxa	123	16	infected	infect	VBN
cord-282246-wyanwvxa	123	17	cells	cell	NNS
cord-282246-wyanwvxa	123	18	.	.	.
cord-282246-wyanwvxa	124	1	VI	VI	NNP
cord-282246-wyanwvxa	124	2	.	.	.
cord-282246-wyanwvxa	125	1	MUCOSAL	MUCOSAL	NNP
cord-282246-wyanwvxa	125	2	VACCINES	vaccine	NNS
cord-282246-wyanwvxa	125	3	FOR	for	IN
cord-282246-wyanwvxa	125	4	VIRAL	viral	JJ
cord-282246-wyanwvxa	125	5	DISEASES	disease	NNS
cord-282246-wyanwvxa	125	6	initial	initial	JJ
cord-282246-wyanwvxa	125	7	IFN	IFN	NNP
cord-282246-wyanwvxa	125	8	induction	induction	NN
cord-282246-wyanwvxa	125	9	phase	phase	NN
cord-282246-wyanwvxa	125	10	followed	follow	VBN
cord-282246-wyanwvxa	125	11	by	by	IN
cord-282246-wyanwvxa	125	12	a	a	DT
cord-282246-wyanwvxa	125	13	ligand	ligand	NN
cord-282246-wyanwvxa	125	14	-	-	HYPH
cord-282246-wyanwvxa	125	15	mediated	mediate	VBN
cord-282246-wyanwvxa	125	16	(	(	-LRB-
cord-282246-wyanwvxa	125	17	and	and	CC
cord-282246-wyanwvxa	125	18	IFN	IFN	NNP
cord-282246-wyanwvxa	125	19	receptor	receptor	NN
cord-282246-wyanwvxa	125	20	-	-	HYPH
cord-282246-wyanwvxa	125	21	relayed	relay	VBN
cord-282246-wyanwvxa	125	22	)	)	-RRB-
cord-282246-wyanwvxa	125	23	amplification	amplification	NN
cord-282246-wyanwvxa	125	24	phase	phase	NN
cord-282246-wyanwvxa	125	25	[	[	-LRB-
cord-282246-wyanwvxa	125	26	7	7	CD
cord-282246-wyanwvxa	125	27	,	,	,
cord-282246-wyanwvxa	125	28	8	8	CD
cord-282246-wyanwvxa	125	29	]	]	-RRB-
cord-282246-wyanwvxa	125	30	.	.	.
cord-282246-wyanwvxa	126	1	As	as	IN
cord-282246-wyanwvxa	126	2	was	be	VBD
cord-282246-wyanwvxa	126	3	discussed	discuss	VBN
cord-282246-wyanwvxa	126	4	above	above	RB
cord-282246-wyanwvxa	126	5	,	,	,
cord-282246-wyanwvxa	126	6	RVs	rv	NNS
cord-282246-wyanwvxa	126	7	are	be	VBP
cord-282246-wyanwvxa	126	8	adept	adept	JJ
cord-282246-wyanwvxa	126	9	at	at	IN
cord-282246-wyanwvxa	126	10	inhibiting	inhibit	VBG
cord-282246-wyanwvxa	126	11	IFN	IFN	NNP
cord-282246-wyanwvxa	126	12	induction	induction	NN
cord-282246-wyanwvxa	126	13	and	and	CC
cord-282246-wyanwvxa	126	14	the	the	DT
cord-282246-wyanwvxa	126	15	RV	RV	NNP
cord-282246-wyanwvxa	126	16	NSP1	NSP1	NNP
cord-282246-wyanwvxa	126	17	protein	protein	NN
cord-282246-wyanwvxa	126	18	functions	function	NNS
cord-282246-wyanwvxa	126	19	to	to	TO
cord-282246-wyanwvxa	126	20	degrade	degrade	VB
cord-282246-wyanwvxa	126	21	the	the	DT
cord-282246-wyanwvxa	126	22	essential	essential	JJ
cord-282246-wyanwvxa	126	23	factors	factor	NNS
cord-282246-wyanwvxa	126	24	β	β	NN
cord-282246-wyanwvxa	126	25	-	-	HYPH
cord-282246-wyanwvxa	126	26	TrCP	TrCP	NNP
cord-282246-wyanwvxa	127	1	and/or	and/or	CC
cord-282246-wyanwvxa	127	2	IRF3	IRF3	NNP
cord-282246-wyanwvxa	128	1	during	during	IN
cord-282246-wyanwvxa	128	2	IFN	IFN	NNP
cord-282246-wyanwvxa	128	3	induction	induction	NN
cord-282246-wyanwvxa	128	4	in	in	IN
cord-282246-wyanwvxa	128	5	a	a	DT
cord-282246-wyanwvxa	128	6	RV	rv	NN
cord-282246-wyanwvxa	128	7	strainspecific	strainspecific	NN
cord-282246-wyanwvxa	128	8	manner	manner	NN
cord-282246-wyanwvxa	128	9	[	[	-LRB-
cord-282246-wyanwvxa	128	10	66	66	CD
cord-282246-wyanwvxa	128	11	]	]	-RRB-
cord-282246-wyanwvxa	128	12	.	.	.
cord-282246-wyanwvxa	129	1	Interestingly	interestingly	RB
cord-282246-wyanwvxa	129	2	,	,	,
cord-282246-wyanwvxa	129	3	in	in	IN
cord-282246-wyanwvxa	129	4	spite	spite	NN
cord-282246-wyanwvxa	129	5	of	of	IN
cord-282246-wyanwvxa	129	6	viral	viral	JJ
cord-282246-wyanwvxa	129	7	antagonism	antagonism	NN
cord-282246-wyanwvxa	129	8	of	of	IN
cord-282246-wyanwvxa	129	9	IFN	IFN	NNP
cord-282246-wyanwvxa	129	10	induction	induction	NN
cord-282246-wyanwvxa	129	11	,	,	,
cord-282246-wyanwvxa	129	12	infection	infection	NN
cord-282246-wyanwvxa	129	13	with	with	IN
cord-282246-wyanwvxa	129	14	RV	RV	NNP
cord-282246-wyanwvxa	129	15	leads	lead	VBZ
cord-282246-wyanwvxa	129	16	to	to	IN
cord-282246-wyanwvxa	129	17	the	the	DT
cord-282246-wyanwvxa	129	18	transcriptional	transcriptional	JJ
cord-282246-wyanwvxa	129	19	induction	induction	NN
cord-282246-wyanwvxa	129	20	and	and	CC
cord-282246-wyanwvxa	129	21	secretion	secretion	NN
cord-282246-wyanwvxa	129	22	of	of	IN
cord-282246-wyanwvxa	129	23	different	different	JJ
cord-282246-wyanwvxa	129	24	IFN	IFN	NNP
cord-282246-wyanwvxa	129	25	types	type	NNS
cord-282246-wyanwvxa	129	26	in	in	IN
cord-282246-wyanwvxa	129	27	both	both	DT
cord-282246-wyanwvxa	129	28	cell	cell	NN
cord-282246-wyanwvxa	129	29	culture	culture	NN
cord-282246-wyanwvxa	129	30	and	and	CC
cord-282246-wyanwvxa	129	31	in	in	IN
cord-282246-wyanwvxa	129	32	vivo	vivo	NNP
cord-282246-wyanwvxa	129	33	[	[	-LRB-
cord-282246-wyanwvxa	129	34	8	8	CD
cord-282246-wyanwvxa	129	35	,	,	,
cord-282246-wyanwvxa	129	36	19	19	CD
cord-282246-wyanwvxa	129	37	,	,	,
cord-282246-wyanwvxa	129	38	26	26	CD
cord-282246-wyanwvxa	129	39	,	,	,
cord-282246-wyanwvxa	129	40	49	49	CD
cord-282246-wyanwvxa	129	41	,	,	,
cord-282246-wyanwvxa	129	42	52	52	CD
cord-282246-wyanwvxa	129	43	,	,	,
cord-282246-wyanwvxa	129	44	67	67	CD
cord-282246-wyanwvxa	129	45	]	]	-RRB-
cord-282246-wyanwvxa	129	46	.	.	.
cord-282246-wyanwvxa	130	1	At	at	RB
cord-282246-wyanwvxa	130	2	least	least	RBS
cord-282246-wyanwvxa	130	3	two	two	CD
cord-282246-wyanwvxa	130	4	factors	factor	NNS
cord-282246-wyanwvxa	130	5	contribute	contribute	VBP
cord-282246-wyanwvxa	130	6	to	to	IN
cord-282246-wyanwvxa	130	7	the	the	DT
cord-282246-wyanwvxa	130	8	failure	failure	NN
cord-282246-wyanwvxa	130	9	of	of	IN
cord-282246-wyanwvxa	130	10	RV	RV	NNP
cord-282246-wyanwvxa	130	11	to	to	TO
cord-282246-wyanwvxa	130	12	completely	completely	RB
cord-282246-wyanwvxa	130	13	suppress	suppress	VB
cord-282246-wyanwvxa	130	14	the	the	DT
cord-282246-wyanwvxa	130	15	induction	induction	NN
cord-282246-wyanwvxa	130	16	of	of	IN
cord-282246-wyanwvxa	130	17	IFN	IFN	NNP
cord-282246-wyanwvxa	130	18	secretion	secretion	NN
cord-282246-wyanwvxa	130	19	.	.	.
cord-282246-wyanwvxa	131	1	First	first	RB
cord-282246-wyanwvxa	131	2	,	,	,
cord-282246-wyanwvxa	131	3	synthesis	synthesis	NN
cord-282246-wyanwvxa	131	4	of	of	IN
cord-282246-wyanwvxa	131	5	the	the	DT
cord-282246-wyanwvxa	131	6	IFN	IFN	NNP
cord-282246-wyanwvxa	131	7	antagonist	antagonist	NN
cord-282246-wyanwvxa	131	8	NSP1	NSP1	NNP
cord-282246-wyanwvxa	131	9	occurs	occur	VBZ
cord-282246-wyanwvxa	131	10	only	only	RB
cord-282246-wyanwvxa	131	11	after	after	IN
cord-282246-wyanwvxa	131	12	viral	viral	JJ
cord-282246-wyanwvxa	131	13	entry	entry	NN
cord-282246-wyanwvxa	131	14	,	,	,
cord-282246-wyanwvxa	131	15	uncoating	uncoating	NN
cord-282246-wyanwvxa	131	16	of	of	IN
cord-282246-wyanwvxa	131	17	the	the	DT
cord-282246-wyanwvxa	131	18	virion	virion	NN
cord-282246-wyanwvxa	131	19	,	,	,
cord-282246-wyanwvxa	131	20	RV	rv	NN
cord-282246-wyanwvxa	131	21	transcription	transcription	NN
cord-282246-wyanwvxa	131	22	,	,	,
cord-282246-wyanwvxa	131	23	and	and	CC
cord-282246-wyanwvxa	131	24	translation	translation	NN
cord-282246-wyanwvxa	131	25	.	.	.
cord-282246-wyanwvxa	132	1	During	during	IN
cord-282246-wyanwvxa	132	2	this	this	DT
cord-282246-wyanwvxa	132	3	initial	initial	JJ
cord-282246-wyanwvxa	132	4	infection	infection	NN
cord-282246-wyanwvxa	132	5	process	process	NN
cord-282246-wyanwvxa	132	6	,	,	,
cord-282246-wyanwvxa	132	7	several	several	JJ
cord-282246-wyanwvxa	132	8	byproducts	byproduct	NNS
cord-282246-wyanwvxa	132	9	of	of	IN
cord-282246-wyanwvxa	132	10	viral	viral	JJ
cord-282246-wyanwvxa	132	11	transcription	transcription	NN
cord-282246-wyanwvxa	132	12	are	be	VBP
cord-282246-wyanwvxa	132	13	generated	generate	VBN
cord-282246-wyanwvxa	132	14	that	that	WDT
cord-282246-wyanwvxa	132	15	act	act	NN
cord-282246-wyanwvxa	132	16	as	as	IN
cord-282246-wyanwvxa	132	17	potent	potent	JJ
cord-282246-wyanwvxa	132	18	triggers	trigger	NNS
cord-282246-wyanwvxa	132	19	of	of	IN
cord-282246-wyanwvxa	132	20	the	the	DT
cord-282246-wyanwvxa	132	21	IFN	IFN	NNP
cord-282246-wyanwvxa	132	22	induction	induction	NN
cord-282246-wyanwvxa	132	23	pathway	pathway	NN
cord-282246-wyanwvxa	132	24	[	[	-LRB-
cord-282246-wyanwvxa	132	25	8	8	CD
cord-282246-wyanwvxa	132	26	,	,	,
cord-282246-wyanwvxa	132	27	10	10	CD
cord-282246-wyanwvxa	132	28	]	]	-RRB-
cord-282246-wyanwvxa	132	29	.	.	.
cord-282246-wyanwvxa	133	1	Second	second	RB
cord-282246-wyanwvxa	133	2	,	,	,
cord-282246-wyanwvxa	133	3	RV	RV	NNP
cord-282246-wyanwvxa	133	4	entry	entry	NN
cord-282246-wyanwvxa	133	5	into	into	IN
cord-282246-wyanwvxa	133	6	different	different	JJ
cord-282246-wyanwvxa	133	7	types	type	NNS
cord-282246-wyanwvxa	133	8	of	of	IN
cord-282246-wyanwvxa	133	9	cells	cell	NNS
cord-282246-wyanwvxa	133	10	may	may	MD
cord-282246-wyanwvxa	133	11	not	not	RB
cord-282246-wyanwvxa	133	12	always	always	RB
cord-282246-wyanwvxa	133	13	result	result	VB
cord-282246-wyanwvxa	133	14	in	in	IN
cord-282246-wyanwvxa	133	15	productive	productive	JJ
cord-282246-wyanwvxa	133	16	infection	infection	NN
cord-282246-wyanwvxa	133	17	.	.	.
cord-282246-wyanwvxa	134	1	For	for	IN
cord-282246-wyanwvxa	134	2	example	example	NN
cord-282246-wyanwvxa	134	3	,	,	,
cord-282246-wyanwvxa	134	4	RV	RV	NNP
cord-282246-wyanwvxa	134	5	exposure	exposure	NN
cord-282246-wyanwvxa	134	6	to	to	IN
cord-282246-wyanwvxa	134	7	primary	primary	JJ
cord-282246-wyanwvxa	134	8	human	human	NN
cord-282246-wyanwvxa	134	9	pDCs	pdcs	NN
cord-282246-wyanwvxa	134	10	results	result	NNS
cord-282246-wyanwvxa	134	11	in	in	IN
cord-282246-wyanwvxa	134	12	two	two	CD
cord-282246-wyanwvxa	134	13	distinct	distinct	JJ
cord-282246-wyanwvxa	134	14	populations	population	NNS
cord-282246-wyanwvxa	134	15	of	of	IN
cord-282246-wyanwvxa	134	16	cells	cell	NNS
cord-282246-wyanwvxa	134	17	that	that	WDT
cord-282246-wyanwvxa	134	18	differ	differ	VBP
cord-282246-wyanwvxa	134	19	in	in	IN
cord-282246-wyanwvxa	134	20	their	-PRON-	PRP$
cord-282246-wyanwvxa	134	21	level	level	NN
cord-282246-wyanwvxa	134	22	of	of	IN
cord-282246-wyanwvxa	134	23	viral	viral	JJ
cord-282246-wyanwvxa	134	24	infectivity	infectivity	NN
cord-282246-wyanwvxa	134	25	[	[	-LRB-
cord-282246-wyanwvxa	134	26	16	16	CD
cord-282246-wyanwvxa	134	27	]	]	-RRB-
cord-282246-wyanwvxa	134	28	.	.	.
cord-282246-wyanwvxa	135	1	Dendritic	dendritic	JJ
cord-282246-wyanwvxa	135	2	cells	cell	NNS
cord-282246-wyanwvxa	135	3	that	that	WDT
cord-282246-wyanwvxa	135	4	are	be	VBP
cord-282246-wyanwvxa	135	5	not	not	RB
cord-282246-wyanwvxa	135	6	productively	productively	RB
cord-282246-wyanwvxa	135	7	infected	infect	VBN
cord-282246-wyanwvxa	135	8	nevertheless	nevertheless	RB
cord-282246-wyanwvxa	135	9	exhibit	exhibit	VBP
cord-282246-wyanwvxa	135	10	robust	robust	JJ
cord-282246-wyanwvxa	135	11	activation	activation	NN
cord-282246-wyanwvxa	135	12	of	of	IN
cord-282246-wyanwvxa	135	13	the	the	DT
cord-282246-wyanwvxa	135	14	IFN	IFN	NNP
cord-282246-wyanwvxa	135	15	induction	induction	NN
cord-282246-wyanwvxa	135	16	response	response	NN
cord-282246-wyanwvxa	135	17	[	[	-LRB-
cord-282246-wyanwvxa	135	18	16	16	CD
cord-282246-wyanwvxa	135	19	,	,	,
cord-282246-wyanwvxa	135	20	27	27	CD
cord-282246-wyanwvxa	135	21	]	]	-RRB-
cord-282246-wyanwvxa	135	22	.	.	.
cord-282246-wyanwvxa	136	1	Given	give	VBN
cord-282246-wyanwvxa	136	2	the	the	DT
cord-282246-wyanwvxa	136	3	remarkable	remarkable	JJ
cord-282246-wyanwvxa	136	4	efficiency	efficiency	NN
cord-282246-wyanwvxa	136	5	of	of	IN
cord-282246-wyanwvxa	136	6	IFN	IFN	NNP
cord-282246-wyanwvxa	136	7	secretion	secretion	NN
cord-282246-wyanwvxa	136	8	in	in	IN
cord-282246-wyanwvxa	136	9	this	this	DT
cord-282246-wyanwvxa	136	10	cell	cell	NN
cord-282246-wyanwvxa	136	11	type	type	NN
cord-282246-wyanwvxa	136	12	,	,	,
cord-282246-wyanwvxa	136	13	they	-PRON-	PRP
cord-282246-wyanwvxa	136	14	are	be	VBP
cord-282246-wyanwvxa	136	15	a	a	DT
cord-282246-wyanwvxa	136	16	likely	likely	JJ
cord-282246-wyanwvxa	136	17	source	source	NN
cord-282246-wyanwvxa	136	18	of	of	IN
cord-282246-wyanwvxa	136	19	substantial	substantial	JJ
cord-282246-wyanwvxa	136	20	IFN	IFN	NNP
cord-282246-wyanwvxa	136	21	secretion	secretion	NN
cord-282246-wyanwvxa	136	22	from	from	IN
cord-282246-wyanwvxa	136	23	a	a	DT
cord-282246-wyanwvxa	136	24	nonepithelial	nonepithelial	JJ
cord-282246-wyanwvxa	136	25	cellular	cellular	JJ
cord-282246-wyanwvxa	136	26	compartment	compartment	NN
cord-282246-wyanwvxa	136	27	where	where	WRB
cord-282246-wyanwvxa	136	28	RV	RV	NNP
cord-282246-wyanwvxa	136	29	does	do	VBZ
cord-282246-wyanwvxa	136	30	not	not	RB
cord-282246-wyanwvxa	136	31	replicate	replicate	VB
cord-282246-wyanwvxa	136	32	efficiently	efficiently	RB
cord-282246-wyanwvxa	136	33	.	.	.
cord-282246-wyanwvxa	137	1	In	in	IN
cord-282246-wyanwvxa	137	2	suckling	suckle	VBG
cord-282246-wyanwvxa	137	3	mice	mouse	NNS
cord-282246-wyanwvxa	137	4	,	,	,
cord-282246-wyanwvxa	137	5	infection	infection	NN
cord-282246-wyanwvxa	137	6	with	with	IN
cord-282246-wyanwvxa	137	7	RV	RV	NNP
cord-282246-wyanwvxa	137	8	leads	lead	VBZ
cord-282246-wyanwvxa	137	9	to	to	IN
cord-282246-wyanwvxa	137	10	significant	significant	JJ
cord-282246-wyanwvxa	137	11	induction	induction	NN
cord-282246-wyanwvxa	137	12	of	of	IN
cord-282246-wyanwvxa	137	13	different	different	JJ
cord-282246-wyanwvxa	137	14	types	type	NNS
cord-282246-wyanwvxa	137	15	of	of	IN
cord-282246-wyanwvxa	137	16	IFNs	ifn	NNS
cord-282246-wyanwvxa	137	17	,	,	,
cord-282246-wyanwvxa	137	18	of	of	IN
cord-282246-wyanwvxa	137	19	which	which	WDT
cord-282246-wyanwvxa	137	20	the	the	DT
cord-282246-wyanwvxa	137	21	type	type	NN
cord-282246-wyanwvxa	137	22	I	-PRON-	PRP
cord-282246-wyanwvxa	137	23	IFNs	ifn	NNS
cord-282246-wyanwvxa	137	24	are	be	VBP
cord-282246-wyanwvxa	137	25	induced	induce	VBN
cord-282246-wyanwvxa	137	26	primarily	primarily	RB
cord-282246-wyanwvxa	137	27	in	in	IN
cord-282246-wyanwvxa	137	28	intestinal	intestinal	JJ
cord-282246-wyanwvxa	137	29	immune	immune	JJ
cord-282246-wyanwvxa	137	30	cells	cell	NNS
cord-282246-wyanwvxa	137	31	rather	rather	RB
cord-282246-wyanwvxa	137	32	than	than	IN
cord-282246-wyanwvxa	137	33	being	be	VBG
cord-282246-wyanwvxa	137	34	derived	derive	VBN
cord-282246-wyanwvxa	137	35	from	from	IN
cord-282246-wyanwvxa	137	36	IECs	iec	NNS
cord-282246-wyanwvxa	137	37	,	,	,
cord-282246-wyanwvxa	137	38	where	where	WRB
cord-282246-wyanwvxa	137	39	viral	viral	JJ
cord-282246-wyanwvxa	137	40	infectivity	infectivity	NN
cord-282246-wyanwvxa	137	41	is	be	VBZ
cord-282246-wyanwvxa	137	42	maximal	maximal	JJ
cord-282246-wyanwvxa	137	43	[	[	-LRB-
cord-282246-wyanwvxa	137	44	26	26	CD
cord-282246-wyanwvxa	137	45	]	]	-RRB-
cord-282246-wyanwvxa	137	46	.	.	.
cord-282246-wyanwvxa	138	1	The	the	DT
cord-282246-wyanwvxa	138	2	secretion	secretion	NN
cord-282246-wyanwvxa	138	3	of	of	IN
cord-282246-wyanwvxa	138	4	IFNs	ifn	NNS
cord-282246-wyanwvxa	138	5	from	from	IN
cord-282246-wyanwvxa	138	6	different	different	JJ
cord-282246-wyanwvxa	138	7	cell	cell	NN
cord-282246-wyanwvxa	138	8	types	type	NNS
cord-282246-wyanwvxa	138	9	poses	pose	VBZ
cord-282246-wyanwvxa	138	10	a	a	DT
cord-282246-wyanwvxa	138	11	unique	unique	JJ
cord-282246-wyanwvxa	138	12	challenge	challenge	NN
cord-282246-wyanwvxa	138	13	to	to	IN
cord-282246-wyanwvxa	138	14	successful	successful	JJ
cord-282246-wyanwvxa	138	15	viral	viral	JJ
cord-282246-wyanwvxa	138	16	propagation	propagation	NN
cord-282246-wyanwvxa	138	17	and	and	CC
cord-282246-wyanwvxa	138	18	spread	spread	VBD
cord-282246-wyanwvxa	138	19	to	to	IN
cord-282246-wyanwvxa	138	20	uninfected	uninfected	JJ
cord-282246-wyanwvxa	138	21	bystander	bystander	NN
cord-282246-wyanwvxa	138	22	IECs	iec	NNS
cord-282246-wyanwvxa	138	23	.	.	.
cord-282246-wyanwvxa	139	1	This	this	DT
cord-282246-wyanwvxa	139	2	is	be	VBZ
cord-282246-wyanwvxa	139	3	because	because	IN
cord-282246-wyanwvxa	139	4	IFN	IFN	NNP
cord-282246-wyanwvxa	139	5	binding	bind	VBG
cord-282246-wyanwvxa	139	6	to	to	IN
cord-282246-wyanwvxa	139	7	its	-PRON-	PRP$
cord-282246-wyanwvxa	139	8	cognate	cognate	JJ
cord-282246-wyanwvxa	139	9	cell	cell	NN
cord-282246-wyanwvxa	139	10	surface	surface	NN
cord-282246-wyanwvxa	139	11	receptor	receptor	NN
cord-282246-wyanwvxa	139	12	activates	activate	VBZ
cord-282246-wyanwvxa	139	13	a	a	DT
cord-282246-wyanwvxa	139	14	positive	positive	JJ
cord-282246-wyanwvxa	139	15	feedback	feedback	NN
cord-282246-wyanwvxa	139	16	loop	loop	NN
cord-282246-wyanwvxa	139	17	that	that	WDT
cord-282246-wyanwvxa	139	18	amplifies	amplify	VBZ
cord-282246-wyanwvxa	139	19	the	the	DT
cord-282246-wyanwvxa	139	20	expression	expression	NN
cord-282246-wyanwvxa	139	21	of	of	IN
cord-282246-wyanwvxa	139	22	IFNs	ifn	NNS
cord-282246-wyanwvxa	139	23	as	as	RB
cord-282246-wyanwvxa	139	24	well	well	RB
cord-282246-wyanwvxa	139	25	as	as	IN
cord-282246-wyanwvxa	139	26	more	more	JJR
cord-282246-wyanwvxa	139	27	than	than	IN
cord-282246-wyanwvxa	139	28	300	300	CD
cord-282246-wyanwvxa	139	29	different	different	JJ
cord-282246-wyanwvxa	139	30	IFN	IFN	NNP
cord-282246-wyanwvxa	139	31	-	-	HYPH
cord-282246-wyanwvxa	139	32	stimulated	stimulate	VBN
cord-282246-wyanwvxa	139	33	genes	gene	NNS
cord-282246-wyanwvxa	139	34	[	[	-LRB-
cord-282246-wyanwvxa	139	35	68	68	CD
cord-282246-wyanwvxa	139	36	]	]	-RRB-
cord-282246-wyanwvxa	139	37	.	.	.
cord-282246-wyanwvxa	140	1	This	this	DT
cord-282246-wyanwvxa	140	2	IFN	IFN	NNP
cord-282246-wyanwvxa	140	3	release	release	NN
cord-282246-wyanwvxa	140	4	then	then	RB
cord-282246-wyanwvxa	140	5	efficiently	efficiently	RB
cord-282246-wyanwvxa	140	6	amplifies	amplify	VBZ
cord-282246-wyanwvxa	140	7	the	the	DT
cord-282246-wyanwvxa	140	8	expression	expression	NN
cord-282246-wyanwvxa	140	9	of	of	IN
cord-282246-wyanwvxa	140	10	antiviral	antiviral	JJ
cord-282246-wyanwvxa	140	11	proteins	protein	NNS
cord-282246-wyanwvxa	140	12	targeting	target	VBG
cord-282246-wyanwvxa	140	13	a	a	DT
cord-282246-wyanwvxa	140	14	variety	variety	NN
cord-282246-wyanwvxa	140	15	of	of	IN
cord-282246-wyanwvxa	140	16	viral	viral	JJ
cord-282246-wyanwvxa	140	17	replication	replication	NN
cord-282246-wyanwvxa	140	18	steps	step	NNS
cord-282246-wyanwvxa	140	19	in	in	IN
cord-282246-wyanwvxa	140	20	uninfected	uninfected	JJ
cord-282246-wyanwvxa	140	21	bystander	bystander	NN
cord-282246-wyanwvxa	140	22	cells	cell	NNS
cord-282246-wyanwvxa	140	23	.	.	.
cord-282246-wyanwvxa	141	1	Each	each	DT
cord-282246-wyanwvxa	141	2	of	of	IN
cord-282246-wyanwvxa	141	3	the	the	DT
cord-282246-wyanwvxa	141	4	three	three	CD
cord-282246-wyanwvxa	141	5	major	major	JJ
cord-282246-wyanwvxa	141	6	IFN	IFN	NNP
cord-282246-wyanwvxa	141	7	types	type	NNS
cord-282246-wyanwvxa	141	8	(	(	-LRB-
cord-282246-wyanwvxa	141	9	I	-PRON-	PRP
cord-282246-wyanwvxa	141	10	,	,	,
cord-282246-wyanwvxa	141	11	II	II	NNP
cord-282246-wyanwvxa	141	12	,	,	,
cord-282246-wyanwvxa	141	13	and	and	CC
cord-282246-wyanwvxa	141	14	III	III	NNP
cord-282246-wyanwvxa	141	15	)	)	-RRB-
cord-282246-wyanwvxa	141	16	that	that	WDT
cord-282246-wyanwvxa	141	17	are	be	VBP
cord-282246-wyanwvxa	141	18	found	find	VBN
cord-282246-wyanwvxa	141	19	to	to	TO
cord-282246-wyanwvxa	141	20	be	be	VB
cord-282246-wyanwvxa	141	21	induced	induce	VBN
cord-282246-wyanwvxa	141	22	in	in	IN
cord-282246-wyanwvxa	141	23	the	the	DT
cord-282246-wyanwvxa	141	24	intestine	intestine	NN
cord-282246-wyanwvxa	141	25	following	follow	VBG
cord-282246-wyanwvxa	141	26	RV	RV	NNP
cord-282246-wyanwvxa	141	27	infection	infection	NN
cord-282246-wyanwvxa	141	28	is	be	VBZ
cord-282246-wyanwvxa	141	29	capable	capable	JJ
cord-282246-wyanwvxa	141	30	of	of	IN
cord-282246-wyanwvxa	141	31	mediating	mediate	VBG
cord-282246-wyanwvxa	141	32	phosphorylation	phosphorylation	NN
cord-282246-wyanwvxa	141	33	of	of	IN
cord-282246-wyanwvxa	141	34	the	the	DT
cord-282246-wyanwvxa	141	35	key	key	JJ
cord-282246-wyanwvxa	141	36	convergent	convergent	JJ
cord-282246-wyanwvxa	141	37	transcription	transcription	NN
cord-282246-wyanwvxa	141	38	factor	factor	NN
cord-282246-wyanwvxa	141	39	STAT1	stat1	XX
cord-282246-wyanwvxa	142	1	(	(	-LRB-
cord-282246-wyanwvxa	142	2	at	at	IN
cord-282246-wyanwvxa	142	3	Y701	Y701	NNP
cord-282246-wyanwvxa	142	4	,	,	,
cord-282246-wyanwvxa	142	5	an	an	DT
cord-282246-wyanwvxa	142	6	event	event	NN
cord-282246-wyanwvxa	142	7	that	that	WDT
cord-282246-wyanwvxa	142	8	is	be	VBZ
cord-282246-wyanwvxa	142	9	critical	critical	JJ
cord-282246-wyanwvxa	142	10	for	for	IN
cord-282246-wyanwvxa	142	11	unlocking	unlock	VBG
cord-282246-wyanwvxa	142	12	the	the	DT
cord-282246-wyanwvxa	142	13	transcriptional	transcriptional	JJ
cord-282246-wyanwvxa	142	14	program	program	NN
cord-282246-wyanwvxa	142	15	resulting	result	VBG
cord-282246-wyanwvxa	142	16	in	in	IN
cord-282246-wyanwvxa	142	17	an	an	DT
cord-282246-wyanwvxa	142	18	antiviral	antiviral	JJ
cord-282246-wyanwvxa	142	19	state	state	NN
cord-282246-wyanwvxa	142	20	)	)	-RRB-
cord-282246-wyanwvxa	142	21	(	(	-LRB-
cord-282246-wyanwvxa	142	22	Fig	Fig	NNP
cord-282246-wyanwvxa	142	23	.	.	.
cord-282246-wyanwvxa	142	24	40.3	40.3	CD
cord-282246-wyanwvxa	142	25	)	)	-RRB-
cord-282246-wyanwvxa	142	26	.	.	.
cord-282246-wyanwvxa	143	1	Each	each	DT
cord-282246-wyanwvxa	143	2	of	of	IN
cord-282246-wyanwvxa	143	3	these	these	DT
cord-282246-wyanwvxa	143	4	IFN	IFN	NNP
cord-282246-wyanwvxa	143	5	types	type	NNS
cord-282246-wyanwvxa	143	6	is	be	VBZ
cord-282246-wyanwvxa	143	7	biologically	biologically	RB
cord-282246-wyanwvxa	143	8	relevant	relevant	JJ
cord-282246-wyanwvxa	143	9	in	in	IN
cord-282246-wyanwvxa	143	10	the	the	DT
cord-282246-wyanwvxa	143	11	context	context	NN
cord-282246-wyanwvxa	143	12	of	of	IN
cord-282246-wyanwvxa	143	13	modulating	modulate	VBG
cord-282246-wyanwvxa	143	14	RV	RV	NNP
cord-282246-wyanwvxa	143	15	infection	infection	NN
cord-282246-wyanwvxa	143	16	and	and	CC
cord-282246-wyanwvxa	143	17	spread	spread	VBD
cord-282246-wyanwvxa	143	18	[	[	-LRB-
cord-282246-wyanwvxa	143	19	7	7	CD
cord-282246-wyanwvxa	143	20	,	,	,
cord-282246-wyanwvxa	143	21	52	52	CD
cord-282246-wyanwvxa	143	22	]	]	-RRB-
cord-282246-wyanwvxa	143	23	.	.	.
cord-282246-wyanwvxa	144	1	Several	several	JJ
cord-282246-wyanwvxa	144	2	lines	line	NNS
cord-282246-wyanwvxa	144	3	of	of	IN
cord-282246-wyanwvxa	144	4	evidence	evidence	NN
cord-282246-wyanwvxa	144	5	indicate	indicate	VBP
cord-282246-wyanwvxa	144	6	that	that	IN
cord-282246-wyanwvxa	144	7	RV	RV	NNP
cord-282246-wyanwvxa	144	8	employs	employ	VBZ
cord-282246-wyanwvxa	144	9	potent	potent	JJ
cord-282246-wyanwvxa	144	10	countermeasures	countermeasure	NNS
cord-282246-wyanwvxa	144	11	to	to	TO
cord-282246-wyanwvxa	144	12	subvert	subvert	VB
cord-282246-wyanwvxa	144	13	the	the	DT
cord-282246-wyanwvxa	144	14	antiviral	antiviral	JJ
cord-282246-wyanwvxa	144	15	state	state	NN
cord-282246-wyanwvxa	144	16	mediated	mediate	VBN
cord-282246-wyanwvxa	144	17	by	by	IN
cord-282246-wyanwvxa	144	18	secreted	secrete	VBN
cord-282246-wyanwvxa	144	19	IFNs	ifn	NNS
cord-282246-wyanwvxa	144	20	during	during	IN
cord-282246-wyanwvxa	144	21	initial	initial	JJ
cord-282246-wyanwvxa	144	22	infection	infection	NN
cord-282246-wyanwvxa	144	23	[	[	-LRB-
cord-282246-wyanwvxa	144	24	7	7	CD
cord-282246-wyanwvxa	144	25	,	,	,
cord-282246-wyanwvxa	144	26	19	19	CD
cord-282246-wyanwvxa	144	27	,	,	,
cord-282246-wyanwvxa	144	28	26	26	CD
cord-282246-wyanwvxa	144	29	,	,	,
cord-282246-wyanwvxa	144	30	52	52	CD
cord-282246-wyanwvxa	144	31	,	,	,
cord-282246-wyanwvxa	144	32	67	67	CD
cord-282246-wyanwvxa	144	33	]	]	-RRB-
cord-282246-wyanwvxa	144	34	.	.	.
cord-282246-wyanwvxa	145	1	In	in	IN
cord-282246-wyanwvxa	145	2	cell	cell	NN
cord-282246-wyanwvxa	145	3	culture	culture	NN
cord-282246-wyanwvxa	145	4	,	,	,
cord-282246-wyanwvxa	145	5	addition	addition	NN
cord-282246-wyanwvxa	145	6	of	of	IN
cord-282246-wyanwvxa	145	7	purified	purify	VBN
cord-282246-wyanwvxa	145	8	exogenous	exogenous	JJ
cord-282246-wyanwvxa	145	9	IFNs	ifn	NNS
cord-282246-wyanwvxa	145	10	after	after	IN
cord-282246-wyanwvxa	145	11	RV	rv	NN
cord-282246-wyanwvxa	145	12	adsorption	adsorption	NN
cord-282246-wyanwvxa	145	13	does	do	VBZ
cord-282246-wyanwvxa	145	14	not	not	RB
cord-282246-wyanwvxa	145	15	significantly	significantly	RB
cord-282246-wyanwvxa	145	16	hamper	hamper	VB
cord-282246-wyanwvxa	145	17	viral	viral	JJ
cord-282246-wyanwvxa	145	18	replication	replication	NN
cord-282246-wyanwvxa	145	19	;	;	:
cord-282246-wyanwvxa	145	20	instead	instead	RB
cord-282246-wyanwvxa	145	21	,	,	,
cord-282246-wyanwvxa	145	22	IFN	IFN	NNP
cord-282246-wyanwvxa	145	23	treatment	treatment	NN
cord-282246-wyanwvxa	145	24	of	of	IN
cord-282246-wyanwvxa	145	25	cells	cell	NNS
cord-282246-wyanwvxa	145	26	prior	prior	RB
cord-282246-wyanwvxa	145	27	to	to	IN
cord-282246-wyanwvxa	145	28	RV	rv	NN
cord-282246-wyanwvxa	145	29	infection	infection	NN
cord-282246-wyanwvxa	145	30	is	be	VBZ
cord-282246-wyanwvxa	145	31	required	require	VBN
cord-282246-wyanwvxa	145	32	to	to	TO
cord-282246-wyanwvxa	145	33	achieve	achieve	VB
cord-282246-wyanwvxa	145	34	efficient	efficient	JJ
cord-282246-wyanwvxa	145	35	RV	rv	NN
cord-282246-wyanwvxa	145	36	replication	replication	NN
cord-282246-wyanwvxa	145	37	restriction	restriction	NN
cord-282246-wyanwvxa	145	38	[	[	-LRB-
cord-282246-wyanwvxa	145	39	69	69	CD
cord-282246-wyanwvxa	145	40	]	]	-RRB-
cord-282246-wyanwvxa	145	41	.	.	.
cord-282246-wyanwvxa	146	1	In	in	IN
cord-282246-wyanwvxa	146	2	the	the	DT
cord-282246-wyanwvxa	146	3	RV	rv	NN
cord-282246-wyanwvxa	146	4	suckling	suckle	VBG
cord-282246-wyanwvxa	146	5	mouse	mouse	NN
cord-282246-wyanwvxa	146	6	model	model	NN
cord-282246-wyanwvxa	146	7	,	,	,
cord-282246-wyanwvxa	146	8	infection	infection	NN
cord-282246-wyanwvxa	146	9	with	with	IN
cord-282246-wyanwvxa	146	10	a	a	DT
cord-282246-wyanwvxa	146	11	homologous	homologous	JJ
cord-282246-wyanwvxa	146	12	murine	murine	NN
cord-282246-wyanwvxa	146	13	RV	rv	NN
cord-282246-wyanwvxa	146	14	and	and	CC
cord-282246-wyanwvxa	146	15	infection	infection	NN
cord-282246-wyanwvxa	146	16	with	with	IN
cord-282246-wyanwvxa	146	17	a	a	DT
cord-282246-wyanwvxa	146	18	heterologous	heterologous	JJ
cord-282246-wyanwvxa	146	19	simian	simian	JJ
cord-282246-wyanwvxa	146	20	RV	RV	NNP
cord-282246-wyanwvxa	146	21	strain	strain	NN
cord-282246-wyanwvxa	146	22	result	result	NN
cord-282246-wyanwvxa	146	23	in	in	IN
cord-282246-wyanwvxa	146	24	comparable	comparable	JJ
cord-282246-wyanwvxa	146	25	levels	level	NNS
cord-282246-wyanwvxa	146	26	of	of	IN
cord-282246-wyanwvxa	146	27	induction	induction	NN
cord-282246-wyanwvxa	146	28	of	of	IN
cord-282246-wyanwvxa	146	29	different	different	JJ
cord-282246-wyanwvxa	146	30	IFNs	ifn	NNS
cord-282246-wyanwvxa	146	31	from	from	IN
cord-282246-wyanwvxa	146	32	the	the	DT
cord-282246-wyanwvxa	146	33	intestine	intestine	NN
cord-282246-wyanwvxa	146	34	[	[	-LRB-
cord-282246-wyanwvxa	146	35	7	7	CD
cord-282246-wyanwvxa	146	36	,	,	,
cord-282246-wyanwvxa	146	37	26	26	CD
cord-282246-wyanwvxa	146	38	]	]	-RRB-
cord-282246-wyanwvxa	146	39	.	.	.
cord-282246-wyanwvxa	147	1	However	however	RB
cord-282246-wyanwvxa	147	2	,	,	,
cord-282246-wyanwvxa	147	3	as	as	IN
cord-282246-wyanwvxa	147	4	was	be	VBD
cord-282246-wyanwvxa	147	5	noted	note	VBN
cord-282246-wyanwvxa	147	6	above	above	RB
cord-282246-wyanwvxa	147	7	,	,	,
cord-282246-wyanwvxa	147	8	the	the	DT
cord-282246-wyanwvxa	147	9	presence	presence	NN
cord-282246-wyanwvxa	147	10	of	of	IN
cord-282246-wyanwvxa	147	11	IFNs	ifn	NNS
cord-282246-wyanwvxa	147	12	during	during	IN
cord-282246-wyanwvxa	147	13	infection	infection	NN
cord-282246-wyanwvxa	147	14	has	have	VBZ
cord-282246-wyanwvxa	147	15	a	a	DT
cord-282246-wyanwvxa	147	16	negligible	negligible	JJ
cord-282246-wyanwvxa	147	17	effect	effect	NN
cord-282246-wyanwvxa	147	18	on	on	IN
cord-282246-wyanwvxa	147	19	murine	murine	JJ
cord-282246-wyanwvxa	147	20	RV	RV	NNP
cord-282246-wyanwvxa	147	21	replication	replication	NN
cord-282246-wyanwvxa	147	22	(	(	-LRB-
cord-282246-wyanwvxa	147	23	B1-log	b1-log	NN
cord-282246-wyanwvxa	147	24	restriction	restriction	NN
cord-282246-wyanwvxa	147	25	in	in	IN
cord-282246-wyanwvxa	147	26	titer	titer	NN
cord-282246-wyanwvxa	147	27	)	)	-RRB-
cord-282246-wyanwvxa	147	28	but	but	CC
cord-282246-wyanwvxa	147	29	has	have	VBZ
cord-282246-wyanwvxa	147	30	a	a	DT
cord-282246-wyanwvxa	147	31	potent	potent	JJ
cord-282246-wyanwvxa	147	32	effect	effect	NN
cord-282246-wyanwvxa	147	33	on	on	IN
cord-282246-wyanwvxa	147	34	heterologous	heterologous	JJ
cord-282246-wyanwvxa	147	35	simian	simian	JJ
cord-282246-wyanwvxa	147	36	RV	RV	NNP
cord-282246-wyanwvxa	147	37	replication	replication	NN
cord-282246-wyanwvxa	147	38	(	(	-LRB-
cord-282246-wyanwvxa	147	39	4-to	4-to	CD
cord-282246-wyanwvxa	147	40	5-log	5-log	JJ
cord-282246-wyanwvxa	147	41	restriction	restriction	NN
cord-282246-wyanwvxa	147	42	in	in	IN
cord-282246-wyanwvxa	147	43	titer	titer	NN
cord-282246-wyanwvxa	147	44	)	)	-RRB-
cord-282246-wyanwvxa	147	45	[	[	-LRB-
cord-282246-wyanwvxa	147	46	26	26	CD
cord-282246-wyanwvxa	147	47	,	,	,
cord-282246-wyanwvxa	147	48	50	50	CD
cord-282246-wyanwvxa	147	49	]	]	-RRB-
cord-282246-wyanwvxa	147	50	.	.	.
cord-282246-wyanwvxa	148	1	These	these	DT
cord-282246-wyanwvxa	148	2	observations	observation	NNS
cord-282246-wyanwvxa	148	3	suggest	suggest	VBP
cord-282246-wyanwvxa	148	4	that	that	IN
cord-282246-wyanwvxa	148	5	in	in	IN
cord-282246-wyanwvxa	148	6	order	order	NN
cord-282246-wyanwvxa	148	7	to	to	TO
cord-282246-wyanwvxa	148	8	replicate	replicate	VB
cord-282246-wyanwvxa	148	9	successfully	successfully	RB
cord-282246-wyanwvxa	148	10	,	,	,
cord-282246-wyanwvxa	148	11	homologous	homologous	JJ
cord-282246-wyanwvxa	148	12	RVs	rv	NNS
cord-282246-wyanwvxa	148	13	have	have	VBP
cord-282246-wyanwvxa	148	14	evolved	evolve	VBN
cord-282246-wyanwvxa	148	15	strategies	strategy	NNS
cord-282246-wyanwvxa	148	16	to	to	TO
cord-282246-wyanwvxa	148	17	induce	induce	VB
cord-282246-wyanwvxa	148	18	resistance	resistance	NN
cord-282246-wyanwvxa	148	19	to	to	IN
cord-282246-wyanwvxa	148	20	the	the	DT
cord-282246-wyanwvxa	148	21	actions	action	NNS
cord-282246-wyanwvxa	148	22	of	of	IN
cord-282246-wyanwvxa	148	23	different	different	JJ
cord-282246-wyanwvxa	148	24	secreted	secrete	VBN
cord-282246-wyanwvxa	148	25	IFN	IFN	NNP
cord-282246-wyanwvxa	148	26	types	type	NNS
cord-282246-wyanwvxa	148	27	in	in	IN
cord-282246-wyanwvxa	148	28	cells	cell	NNS
cord-282246-wyanwvxa	148	29	prior	prior	RB
cord-282246-wyanwvxa	148	30	to	to	IN
cord-282246-wyanwvxa	148	31	their	-PRON-	PRP$
cord-282246-wyanwvxa	148	32	actual	actual	JJ
cord-282246-wyanwvxa	148	33	infection	infection	NN
cord-282246-wyanwvxa	148	34	(	(	-LRB-
cord-282246-wyanwvxa	148	35	bystander	bystander	NN
cord-282246-wyanwvxa	148	36	cells	cell	NNS
cord-282246-wyanwvxa	148	37	)	)	-RRB-
cord-282246-wyanwvxa	148	38	.	.	.
cord-282246-wyanwvxa	149	1	Classical	classical	JJ
cord-282246-wyanwvxa	149	2	reassortment	reassortment	JJ
cord-282246-wyanwvxa	149	3	genetic	genetic	JJ
cord-282246-wyanwvxa	149	4	studies	study	NNS
cord-282246-wyanwvxa	149	5	of	of	IN
cord-282246-wyanwvxa	149	6	the	the	DT
cord-282246-wyanwvxa	149	7	IFN	IFN	NNP
cord-282246-wyanwvxa	149	8	-	-	HYPH
cord-282246-wyanwvxa	149	9	mediated	mediate	VBN
cord-282246-wyanwvxa	149	10	replication	replication	NN
cord-282246-wyanwvxa	149	11	phenotype	phenotype	NN
cord-282246-wyanwvxa	149	12	of	of	IN
cord-282246-wyanwvxa	149	13	murine	murine	JJ
cord-282246-wyanwvxa	149	14	and	and	CC
cord-282246-wyanwvxa	149	15	simian	simian	JJ
cord-282246-wyanwvxa	149	16	RVs	rv	NNS
cord-282246-wyanwvxa	149	17	implicated	implicate	VBD
cord-282246-wyanwvxa	149	18	a	a	DT
cord-282246-wyanwvxa	149	19	constellation	constellation	NN
cord-282246-wyanwvxa	149	20	of	of	IN
cord-282246-wyanwvxa	149	21	RV	RV	NNP
cord-282246-wyanwvxa	149	22	genes	gene	NNS
cord-282246-wyanwvxa	149	23	(	(	-LRB-
cord-282246-wyanwvxa	149	24	encoding	encode	VBG
cord-282246-wyanwvxa	149	25	the	the	DT
cord-282246-wyanwvxa	149	26	VP3	vp3	NN
cord-282246-wyanwvxa	149	27	,	,	,
cord-282246-wyanwvxa	149	28	NSP1	NSP1	NNP
cord-282246-wyanwvxa	149	29	,	,	,
cord-282246-wyanwvxa	149	30	NSP2	NSP2	NNP
cord-282246-wyanwvxa	149	31	,	,	,
cord-282246-wyanwvxa	149	32	and	and	CC
cord-282246-wyanwvxa	149	33	NSP3	nsp3	CD
cord-282246-wyanwvxa	149	34	viral	viral	JJ
cord-282246-wyanwvxa	149	35	proteins	protein	NNS
cord-282246-wyanwvxa	149	36	)	)	-RRB-
cord-282246-wyanwvxa	149	37	in	in	IN
cord-282246-wyanwvxa	149	38	determining	determine	VBG
cord-282246-wyanwvxa	149	39	the	the	DT
cord-282246-wyanwvxa	149	40	resistance	resistance	NN
cord-282246-wyanwvxa	149	41	to	to	IN
cord-282246-wyanwvxa	149	42	IFN	IFN	NNP
cord-282246-wyanwvxa	149	43	signaling	signal	VBG
cord-282246-wyanwvxa	149	44	[	[	-LRB-
cord-282246-wyanwvxa	149	45	51	51	CD
cord-282246-wyanwvxa	149	46	]	]	-RRB-
cord-282246-wyanwvxa	149	47	.	.	.
cord-282246-wyanwvxa	150	1	Of	of	IN
cord-282246-wyanwvxa	150	2	these	these	DT
cord-282246-wyanwvxa	150	3	,	,	,
cord-282246-wyanwvxa	150	4	NSP1	NSP1	NNP
cord-282246-wyanwvxa	150	5	is	be	VBZ
cord-282246-wyanwvxa	150	6	a	a	DT
cord-282246-wyanwvxa	150	7	necessary	necessary	JJ
cord-282246-wyanwvxa	150	8	and	and	CC
cord-282246-wyanwvxa	150	9	the	the	DT
cord-282246-wyanwvxa	150	10	major	major	JJ
cord-282246-wyanwvxa	150	11	determinant	determinant	NN
cord-282246-wyanwvxa	150	12	of	of	IN
cord-282246-wyanwvxa	150	13	efficient	efficient	JJ
cord-282246-wyanwvxa	150	14	intestinal	intestinal	JJ
cord-282246-wyanwvxa	150	15	RV	rv	NN
cord-282246-wyanwvxa	150	16	replication	replication	NN
cord-282246-wyanwvxa	150	17	in	in	IN
cord-282246-wyanwvxa	150	18	an	an	DT
cord-282246-wyanwvxa	150	19	IFN	IFN	NNP
cord-282246-wyanwvxa	150	20	-	-	HYPH
cord-282246-wyanwvxa	150	21	dependent	dependent	JJ
cord-282246-wyanwvxa	150	22	fashion	fashion	NN
cord-282246-wyanwvxa	150	23	.	.	.
cord-282246-wyanwvxa	151	1	Direct	direct	JJ
cord-282246-wyanwvxa	151	2	evidence	evidence	NN
cord-282246-wyanwvxa	151	3	for	for	IN
cord-282246-wyanwvxa	151	4	RV	rv	NN
cord-282246-wyanwvxa	151	5	subversion	subversion	NN
cord-282246-wyanwvxa	151	6	of	of	IN
cord-282246-wyanwvxa	151	7	the	the	DT
cord-282246-wyanwvxa	151	8	antiviral	antiviral	JJ
cord-282246-wyanwvxa	151	9	state	state	NN
cord-282246-wyanwvxa	151	10	mediated	mediate	VBN
cord-282246-wyanwvxa	151	11	by	by	IN
cord-282246-wyanwvxa	151	12	exogenous	exogenous	JJ
cord-282246-wyanwvxa	151	13	IFNs	ifn	NNS
cord-282246-wyanwvxa	151	14	comes	come	VBZ
cord-282246-wyanwvxa	151	15	from	from	IN
cord-282246-wyanwvxa	151	16	the	the	DT
cord-282246-wyanwvxa	151	17	finding	finding	NN
cord-282246-wyanwvxa	151	18	that	that	IN
cord-282246-wyanwvxa	151	19	RV	rv	NN
cord-282246-wyanwvxa	151	20	-	-	HYPH
cord-282246-wyanwvxa	151	21	infected	infect	VBN
cord-282246-wyanwvxa	151	22	HT-29	HT-29	NNP
cord-282246-wyanwvxa	151	23	cells	cell	NNS
cord-282246-wyanwvxa	151	24	(	(	-LRB-
cord-282246-wyanwvxa	151	25	a	a	DT
cord-282246-wyanwvxa	151	26	human	human	JJ
cord-282246-wyanwvxa	151	27	IEC	IEC	NNP
cord-282246-wyanwvxa	151	28	colonic	colonic	JJ
cord-282246-wyanwvxa	151	29	cancer	cancer	NN
cord-282246-wyanwvxa	151	30	cell	cell	NN
cord-282246-wyanwvxa	151	31	derived	derive	VBN
cord-282246-wyanwvxa	151	32	line	line	NN
cord-282246-wyanwvxa	151	33	)	)	-RRB-
cord-282246-wyanwvxa	151	34	are	be	VBP
cord-282246-wyanwvxa	151	35	able	able	JJ
cord-282246-wyanwvxa	151	36	to	to	TO
cord-282246-wyanwvxa	151	37	efficiently	efficiently	RB
cord-282246-wyanwvxa	151	38	block	block	VB
cord-282246-wyanwvxa	151	39	STAT1-Y701	STAT1-Y701	NNP
cord-282246-wyanwvxa	151	40	phosphorylation	phosphorylation	NN
cord-282246-wyanwvxa	151	41	in	in	IN
cord-282246-wyanwvxa	151	42	response	response	NN
cord-282246-wyanwvxa	151	43	to	to	IN
cord-282246-wyanwvxa	151	44	exogenously	exogenously	RB
cord-282246-wyanwvxa	151	45	added	add	VBN
cord-282246-wyanwvxa	151	46	purified	purify	VBN
cord-282246-wyanwvxa	151	47	IFNs	IFNs	NNP
cord-282246-wyanwvxa	151	48	I	I	NNP
cord-282246-wyanwvxa	151	49	and	and	CC
cord-282246-wyanwvxa	151	50	II	II	NNP
cord-282246-wyanwvxa	151	51	[	[	-LRB-
cord-282246-wyanwvxa	151	52	52	52	CD
cord-282246-wyanwvxa	151	53	,	,	,
cord-282246-wyanwvxa	151	54	67	67	CD
cord-282246-wyanwvxa	151	55	]	]	-RRB-
cord-282246-wyanwvxa	151	56	.	.	.
cord-282246-wyanwvxa	152	1	Using	use	VBG
cord-282246-wyanwvxa	152	2	single	single	JJ
cord-282246-wyanwvxa	152	3	-	-	HYPH
cord-282246-wyanwvxa	152	4	cell	cell	NN
cord-282246-wyanwvxa	152	5	analytic	analytic	JJ
cord-282246-wyanwvxa	152	6	techniques	technique	NNS
cord-282246-wyanwvxa	152	7	,	,	,
cord-282246-wyanwvxa	152	8	IFN	IFN	NNP
cord-282246-wyanwvxa	152	9	-	-	HYPH
cord-282246-wyanwvxa	152	10	mediated	mediate	VBN
cord-282246-wyanwvxa	152	11	STAT1	stat1	NN
cord-282246-wyanwvxa	152	12	inhibition	inhibition	NN
cord-282246-wyanwvxa	152	13	is	be	VBZ
cord-282246-wyanwvxa	152	14	found	find	VBN
cord-282246-wyanwvxa	152	15	to	to	TO
cord-282246-wyanwvxa	152	16	occur	occur	VB
cord-282246-wyanwvxa	152	17	within	within	IN
cord-282246-wyanwvxa	152	18	RVinfected	rvinfected	JJ
cord-282246-wyanwvxa	152	19	cells	cell	NNS
cord-282246-wyanwvxa	152	20	.	.	.
cord-282246-wyanwvxa	153	1	Remarkably	remarkably	RB
cord-282246-wyanwvxa	153	2	,	,	,
cord-282246-wyanwvxa	153	3	STAT1	stat1	VB
cord-282246-wyanwvxa	153	4	responses	response	NNS
cord-282246-wyanwvxa	153	5	to	to	IN
cord-282246-wyanwvxa	153	6	exogenous	exogenous	JJ
cord-282246-wyanwvxa	153	7	IFN	IFN	NNP
cord-282246-wyanwvxa	153	8	ligand	ligand	NN
cord-282246-wyanwvxa	153	9	are	be	VBP
cord-282246-wyanwvxa	153	10	also	also	RB
cord-282246-wyanwvxa	153	11	potently	potently	RB
cord-282246-wyanwvxa	153	12	inhibited	inhibit	VBN
cord-282246-wyanwvxa	153	13	in	in	IN
cord-282246-wyanwvxa	153	14	RV	rv	NN
cord-282246-wyanwvxa	153	15	uninfected	uninfected	JJ
cord-282246-wyanwvxa	153	16	bystander	bystander	NN
cord-282246-wyanwvxa	153	17	cells	cell	NNS
cord-282246-wyanwvxa	153	18	,	,	,
cord-282246-wyanwvxa	153	19	which	which	WDT
cord-282246-wyanwvxa	153	20	do	do	VBP
cord-282246-wyanwvxa	153	21	not	not	RB
cord-282246-wyanwvxa	153	22	express	express	VB
cord-282246-wyanwvxa	153	23	any	any	DT
cord-282246-wyanwvxa	153	24	detectable	detectable	JJ
cord-282246-wyanwvxa	153	25	viral	viral	JJ
cord-282246-wyanwvxa	153	26	antigen	antigen	NN
cord-282246-wyanwvxa	153	27	[	[	-LRB-
cord-282246-wyanwvxa	153	28	67	67	CD
cord-282246-wyanwvxa	153	29	]	]	-RRB-
cord-282246-wyanwvxa	153	30	(	(	-LRB-
cord-282246-wyanwvxa	153	31	Fig	Fig	NNP
cord-282246-wyanwvxa	153	32	.	.	.
cord-282246-wyanwvxa	153	33	40.3	40.3	CD
cord-282246-wyanwvxa	153	34	)	)	-RRB-
cord-282246-wyanwvxa	153	35	.	.	.
cord-282246-wyanwvxa	154	1	Although	although	IN
cord-282246-wyanwvxa	154	2	initially	initially	RB
cord-282246-wyanwvxa	154	3	described	describe	VBD
cord-282246-wyanwvxa	154	4	for	for	IN
cord-282246-wyanwvxa	154	5	a	a	DT
cord-282246-wyanwvxa	154	6	porcine	porcine	JJ
cord-282246-wyanwvxa	154	7	RV	RV	NNP
cord-282246-wyanwvxa	154	8	strain	strain	NN
cord-282246-wyanwvxa	154	9	SB1-A	SB1-A	NNP
cord-282246-wyanwvxa	154	10	,	,	,
cord-282246-wyanwvxa	154	11	this	this	DT
cord-282246-wyanwvxa	154	12	bystander	bystander	NN
cord-282246-wyanwvxa	154	13	inhibitory	inhibitory	JJ
cord-282246-wyanwvxa	154	14	effect	effect	NN
cord-282246-wyanwvxa	154	15	has	have	VBZ
cord-282246-wyanwvxa	154	16	now	now	RB
cord-282246-wyanwvxa	154	17	been	be	VBN
cord-282246-wyanwvxa	154	18	observed	observe	VBN
cord-282246-wyanwvxa	154	19	in	in	IN
cord-282246-wyanwvxa	154	20	vitro	vitro	FW
cord-282246-wyanwvxa	154	21	with	with	IN
cord-282246-wyanwvxa	154	22	several	several	JJ
cord-282246-wyanwvxa	154	23	other	other	JJ
cord-282246-wyanwvxa	154	24	RV	RV	NNP
cord-282246-wyanwvxa	154	25	strains	strain	NNS
cord-282246-wyanwvxa	154	26	,	,	,
cord-282246-wyanwvxa	154	27	albeit	albeit	IN
cord-282246-wyanwvxa	154	28	with	with	IN
cord-282246-wyanwvxa	154	29	lower	low	JJR
cord-282246-wyanwvxa	154	30	efficiency	efficiency	NN
cord-282246-wyanwvxa	154	31	(	(	-LRB-
cord-282246-wyanwvxa	154	32	Sen	Sen	NNP
cord-282246-wyanwvxa	154	33	and	and	CC
cord-282246-wyanwvxa	154	34	Greenberg	Greenberg	NNP
cord-282246-wyanwvxa	154	35	,	,	,
cord-282246-wyanwvxa	154	36	unpublished	unpublished	JJ
cord-282246-wyanwvxa	154	37	observations	observation	NNS
cord-282246-wyanwvxa	154	38	)	)	-RRB-
cord-282246-wyanwvxa	154	39	.	.	.
cord-282246-wyanwvxa	155	1	The	the	DT
cord-282246-wyanwvxa	155	2	ability	ability	NN
cord-282246-wyanwvxa	155	3	of	of	IN
cord-282246-wyanwvxa	155	4	RV	RV	NNP
cord-282246-wyanwvxa	155	5	to	to	TO
cord-282246-wyanwvxa	155	6	block	block	VB
cord-282246-wyanwvxa	155	7	IFNdependent	ifndependent	NN
cord-282246-wyanwvxa	155	8	signaling	signaling	NN
cord-282246-wyanwvxa	155	9	has	have	VBZ
cord-282246-wyanwvxa	155	10	also	also	RB
cord-282246-wyanwvxa	155	11	been	be	VBN
cord-282246-wyanwvxa	155	12	observed	observe	VBN
cord-282246-wyanwvxa	155	13	in	in	IN
cord-282246-wyanwvxa	155	14	vivo	vivo	NNP
cord-282246-wyanwvxa	155	15	.	.	.
cord-282246-wyanwvxa	156	1	Suckling	suckle	VBG
cord-282246-wyanwvxa	156	2	mice	mouse	NNS
cord-282246-wyanwvxa	156	3	infected	infect	VBN
cord-282246-wyanwvxa	156	4	with	with	IN
cord-282246-wyanwvxa	156	5	murine	murine	JJ
cord-282246-wyanwvxa	156	6	RV	RV	NNP
cord-282246-wyanwvxa	156	7	are	be	VBP
cord-282246-wyanwvxa	156	8	able	able	JJ
cord-282246-wyanwvxa	156	9	to	to	TO
cord-282246-wyanwvxa	156	10	significantly	significantly	RB
cord-282246-wyanwvxa	156	11	suppress	suppress	VB
cord-282246-wyanwvxa	156	12	IEC	IEC	NNP
cord-282246-wyanwvxa	156	13	STAT1-Y701	STAT1-Y701	NNP
cord-282246-wyanwvxa	156	14	phosphorylation	phosphorylation	NN
cord-282246-wyanwvxa	156	15	and	and	CC
cord-282246-wyanwvxa	156	16	subsequent	subsequent	JJ
cord-282246-wyanwvxa	156	17	transcription	transcription	NN
cord-282246-wyanwvxa	156	18	that	that	WDT
cord-282246-wyanwvxa	156	19	occurs	occur	VBZ
cord-282246-wyanwvxa	156	20	in	in	IN
cord-282246-wyanwvxa	156	21	response	response	NN
cord-282246-wyanwvxa	156	22	to	to	TO
cord-282246-wyanwvxa	156	23	parenterally	parenterally	RB
cord-282246-wyanwvxa	156	24	FIGURE	figure	VB
cord-282246-wyanwvxa	156	25	40	40	CD
cord-282246-wyanwvxa	156	26	.3	.3	.
cord-282246-wyanwvxa	157	1	RV	rv	NN
cord-282246-wyanwvxa	157	2	regulation	regulation	NN
cord-282246-wyanwvxa	157	3	of	of	IN
cord-282246-wyanwvxa	157	4	the	the	DT
cord-282246-wyanwvxa	157	5	IFN	IFN	NNP
cord-282246-wyanwvxa	157	6	amplification	amplification	NN
cord-282246-wyanwvxa	157	7	pathway	pathway	NN
cord-282246-wyanwvxa	157	8	.	.	.
cord-282246-wyanwvxa	158	1	Following	follow	VBG
cord-282246-wyanwvxa	158	2	infection	infection	NN
cord-282246-wyanwvxa	158	3	,	,	,
cord-282246-wyanwvxa	158	4	RV	RV	NNP
cord-282246-wyanwvxa	158	5	NSP1	NSP1	NNP
cord-282246-wyanwvxa	158	6	efficiently	efficiently	RB
cord-282246-wyanwvxa	158	7	blocks	block	VBZ
cord-282246-wyanwvxa	158	8	exogenous	exogenous	JJ
cord-282246-wyanwvxa	158	9	IFN	IFN	NNP
cord-282246-wyanwvxa	158	10	-	-	HYPH
cord-282246-wyanwvxa	158	11	directed	direct	VBN
cord-282246-wyanwvxa	158	12	phosphorylation	phosphorylation	NN
cord-282246-wyanwvxa	158	13	of	of	IN
cord-282246-wyanwvxa	158	14	STAT1	stat1	NN
cord-282246-wyanwvxa	158	15	at	at	IN
cord-282246-wyanwvxa	158	16	Y701	y701	NN
cord-282246-wyanwvxa	158	17	,	,	,
cord-282246-wyanwvxa	158	18	shown	show	VBN
cord-282246-wyanwvxa	158	19	here	here	RB
cord-282246-wyanwvxa	158	20	for	for	IN
cord-282246-wyanwvxa	158	21	the	the	DT
cord-282246-wyanwvxa	158	22	IFNAR1	ifnar1	NN
cord-282246-wyanwvxa	158	23	(	(	-LRB-
cord-282246-wyanwvxa	158	24	1	1	CD
cord-282246-wyanwvxa	158	25	)	)	-RRB-
cord-282246-wyanwvxa	158	26	.	.	.
cord-282246-wyanwvxa	159	1	In	in	IN
cord-282246-wyanwvxa	159	2	the	the	DT
cord-282246-wyanwvxa	159	3	virus	virus	NN
cord-282246-wyanwvxa	159	4	-	-	HYPH
cord-282246-wyanwvxa	159	5	infected	infect	VBN
cord-282246-wyanwvxa	159	6	cell	cell	NN
cord-282246-wyanwvxa	159	7	,	,	,
cord-282246-wyanwvxa	159	8	RV	RV	NNP
cord-282246-wyanwvxa	159	9	also	also	RB
cord-282246-wyanwvxa	159	10	mediates	mediate	VBZ
cord-282246-wyanwvxa	159	11	the	the	DT
cord-282246-wyanwvxa	159	12	lysosomal	lysosomal	JJ
cord-282246-wyanwvxa	159	13	degradation	degradation	NN
cord-282246-wyanwvxa	159	14	of	of	IN
cord-282246-wyanwvxa	159	15	receptors	receptor	NNS
cord-282246-wyanwvxa	159	16	for	for	IN
cord-282246-wyanwvxa	159	17	types	type	NNS
cord-282246-wyanwvxa	159	18	I	-PRON-	PRP
cord-282246-wyanwvxa	159	19	,	,	,
cord-282246-wyanwvxa	159	20	II	II	NNP
cord-282246-wyanwvxa	159	21	,	,	,
cord-282246-wyanwvxa	159	22	and	and	CC
cord-282246-wyanwvxa	159	23	III	III	NNP
cord-282246-wyanwvxa	159	24	IFN	IFN	NNP
cord-282246-wyanwvxa	159	25	by	by	IN
cord-282246-wyanwvxa	159	26	an	an	DT
cord-282246-wyanwvxa	159	27	unknown	unknown	JJ
cord-282246-wyanwvxa	159	28	process	process	NN
cord-282246-wyanwvxa	159	29	(	(	-LRB-
cord-282246-wyanwvxa	159	30	2	2	CD
cord-282246-wyanwvxa	159	31	)	)	-RRB-
cord-282246-wyanwvxa	159	32	.	.	.
cord-282246-wyanwvxa	160	1	Along	along	IN
cord-282246-wyanwvxa	160	2	with	with	IN
cord-282246-wyanwvxa	160	3	IRF3	IRF3	NNP
cord-282246-wyanwvxa	160	4	and	and	CC
cord-282246-wyanwvxa	160	5	IRF5	IRF5	NNP
cord-282246-wyanwvxa	160	6	,	,	,
cord-282246-wyanwvxa	160	7	the	the	DT
cord-282246-wyanwvxa	160	8	viral	viral	JJ
cord-282246-wyanwvxa	160	9	NSP1	NSP1	NNP
cord-282246-wyanwvxa	160	10	protein	protein	NN
cord-282246-wyanwvxa	160	11	also	also	RB
cord-282246-wyanwvxa	160	12	proteasomally	proteasomally	RB
cord-282246-wyanwvxa	160	13	degrades	degrade	VBZ
cord-282246-wyanwvxa	160	14	IRF9	IRF9	NNP
cord-282246-wyanwvxa	160	15	and	and	CC
cord-282246-wyanwvxa	160	16	IRF7	IRF7	NNP
cord-282246-wyanwvxa	160	17	in	in	IN
cord-282246-wyanwvxa	160	18	the	the	DT
cord-282246-wyanwvxa	160	19	infected	infected	JJ
cord-282246-wyanwvxa	160	20	cells	cell	NNS
cord-282246-wyanwvxa	160	21	,	,	,
cord-282246-wyanwvxa	160	22	which	which	WDT
cord-282246-wyanwvxa	160	23	are	be	VBP
cord-282246-wyanwvxa	160	24	required	require	VBN
cord-282246-wyanwvxa	160	25	for	for	IN
cord-282246-wyanwvxa	160	26	optimal	optimal	JJ
cord-282246-wyanwvxa	160	27	IFN	IFN	NNP
cord-282246-wyanwvxa	160	28	amplification	amplification	NN
cord-282246-wyanwvxa	160	29	responses	response	NNS
cord-282246-wyanwvxa	160	30	(	(	-LRB-
cord-282246-wyanwvxa	160	31	3	3	CD
cord-282246-wyanwvxa	160	32	)	)	-RRB-
cord-282246-wyanwvxa	160	33	.	.	.
cord-282246-wyanwvxa	161	1	In	in	IN
cord-282246-wyanwvxa	161	2	addition	addition	NN
cord-282246-wyanwvxa	161	3	,	,	,
cord-282246-wyanwvxa	161	4	RV	RV	NNP
cord-282246-wyanwvxa	161	5	can	can	MD
cord-282246-wyanwvxa	161	6	inhibit	inhibit	VB
cord-282246-wyanwvxa	161	7	the	the	DT
cord-282246-wyanwvxa	161	8	nuclear	nuclear	JJ
cord-282246-wyanwvxa	161	9	translocation	translocation	NN
cord-282246-wyanwvxa	161	10	of	of	IN
cord-282246-wyanwvxa	161	11	STAT1-pY701	STAT1-pY701	VBG
cord-282246-wyanwvxa	161	12	by	by	IN
cord-282246-wyanwvxa	161	13	an	an	DT
cord-282246-wyanwvxa	161	14	unknown	unknown	JJ
cord-282246-wyanwvxa	161	15	mechanism	mechanism	NN
cord-282246-wyanwvxa	161	16	(	(	-LRB-
cord-282246-wyanwvxa	161	17	4	4	CD
cord-282246-wyanwvxa	161	18	)	)	-RRB-
cord-282246-wyanwvxa	161	19	.	.	.
cord-282246-wyanwvxa	162	1	Remarkably	remarkably	RB
cord-282246-wyanwvxa	162	2	,	,	,
cord-282246-wyanwvxa	162	3	in	in	IN
cord-282246-wyanwvxa	162	4	addition	addition	NN
cord-282246-wyanwvxa	162	5	to	to	IN
cord-282246-wyanwvxa	162	6	these	these	DT
cord-282246-wyanwvxa	162	7	viral	viral	JJ
cord-282246-wyanwvxa	162	8	effects	effect	NNS
cord-282246-wyanwvxa	162	9	in	in	IN
cord-282246-wyanwvxa	162	10	infected	infected	JJ
cord-282246-wyanwvxa	162	11	cells	cell	NNS
cord-282246-wyanwvxa	162	12	,	,	,
cord-282246-wyanwvxa	162	13	RV	RV	NNP
cord-282246-wyanwvxa	162	14	also	also	RB
cord-282246-wyanwvxa	162	15	potently	potently	RB
cord-282246-wyanwvxa	162	16	inhibits	inhibit	VBZ
cord-282246-wyanwvxa	162	17	STAT1	stat1	NN
cord-282246-wyanwvxa	162	18	phosphorylation	phosphorylation	NN
cord-282246-wyanwvxa	162	19	in	in	IN
cord-282246-wyanwvxa	162	20	uninfected	uninfected	JJ
cord-282246-wyanwvxa	162	21	bystander	bystander	NN
cord-282246-wyanwvxa	162	22	cells	cell	NNS
cord-282246-wyanwvxa	162	23	in	in	IN
cord-282246-wyanwvxa	162	24	response	response	NN
cord-282246-wyanwvxa	162	25	to	to	IN
cord-282246-wyanwvxa	162	26	different	different	JJ
cord-282246-wyanwvxa	162	27	types	type	NNS
cord-282246-wyanwvxa	162	28	of	of	IN
cord-282246-wyanwvxa	162	29	IFNs	ifn	NNS
cord-282246-wyanwvxa	162	30	(	(	-LRB-
cord-282246-wyanwvxa	162	31	5	5	CD
cord-282246-wyanwvxa	162	32	)	)	-RRB-
cord-282246-wyanwvxa	162	33	.	.	.
cord-282246-wyanwvxa	163	1	The	the	DT
cord-282246-wyanwvxa	163	2	viral	viral	JJ
cord-282246-wyanwvxa	163	3	and	and	CC
cord-282246-wyanwvxa	163	4	host	host	NN
cord-282246-wyanwvxa	163	5	factors	factor	NNS
cord-282246-wyanwvxa	163	6	underlying	underlie	VBG
cord-282246-wyanwvxa	163	7	this	this	DT
cord-282246-wyanwvxa	163	8	bystander	bystander	NN
cord-282246-wyanwvxa	163	9	inhibition	inhibition	NN
cord-282246-wyanwvxa	163	10	of	of	IN
cord-282246-wyanwvxa	163	11	IFNs	ifn	NNS
cord-282246-wyanwvxa	163	12	are	be	VBP
cord-282246-wyanwvxa	163	13	unknown	unknown	JJ
cord-282246-wyanwvxa	163	14	.	.	.
cord-282246-wyanwvxa	164	1	VI	VI	NNP
cord-282246-wyanwvxa	164	2	.	.	.
cord-282246-wyanwvxa	165	1	MUCOSAL	MUCOSAL	NNP
cord-282246-wyanwvxa	165	2	VACCINES	vaccine	NNS
cord-282246-wyanwvxa	165	3	FOR	for	IN
cord-282246-wyanwvxa	165	4	VIRAL	viral	JJ
cord-282246-wyanwvxa	165	5	DISEASES	disease	NNS
cord-282246-wyanwvxa	165	6	administered	administer	VBN
cord-282246-wyanwvxa	165	7	purified	purify	VBN
cord-282246-wyanwvxa	165	8	IFNs	ifn	NNS
cord-282246-wyanwvxa	165	9	I	-PRON-	PRP
cord-282246-wyanwvxa	165	10	or	or	CC
cord-282246-wyanwvxa	165	11	III	III	NNP
cord-282246-wyanwvxa	165	12	[	[	-LRB-
cord-282246-wyanwvxa	165	13	52	52	CD
cord-282246-wyanwvxa	165	14	]	]	-RRB-
cord-282246-wyanwvxa	165	15	.	.	.
cord-282246-wyanwvxa	166	1	Although	although	IN
cord-282246-wyanwvxa	166	2	IFNA4	IFNA4	NNS
cord-282246-wyanwvxa	166	3	,	,	,
cord-282246-wyanwvxa	166	4	IFNA5	IFNA5	NNP
cord-282246-wyanwvxa	166	5	,	,	,
cord-282246-wyanwvxa	166	6	and	and	CC
cord-282246-wyanwvxa	166	7	IFNA5	IFNA5	NNP
cord-282246-wyanwvxa	166	8	transcripts	transcript	NNS
cord-282246-wyanwvxa	166	9	are	be	VBP
cord-282246-wyanwvxa	166	10	induced	induce	VBN
cord-282246-wyanwvxa	166	11	in	in	IN
cord-282246-wyanwvxa	166	12	the	the	DT
cord-282246-wyanwvxa	166	13	intestines	intestine	NNS
cord-282246-wyanwvxa	166	14	of	of	IN
cord-282246-wyanwvxa	166	15	murine	murine	JJ
cord-282246-wyanwvxa	166	16	RV	rv	NN
cord-282246-wyanwvxa	166	17	-	-	HYPH
cord-282246-wyanwvxa	166	18	infected	infect	VBN
cord-282246-wyanwvxa	166	19	mice	mouse	NNS
cord-282246-wyanwvxa	166	20	,	,	,
cord-282246-wyanwvxa	166	21	transcriptional	transcriptional	JJ
cord-282246-wyanwvxa	166	22	analysis	analysis	NN
cord-282246-wyanwvxa	166	23	of	of	IN
cord-282246-wyanwvxa	166	24	isolated	isolate	VBN
cord-282246-wyanwvxa	166	25	mature	mature	JJ
cord-282246-wyanwvxa	166	26	villous	villous	NNP
cord-282246-wyanwvxa	166	27	enterocytes	enterocytes	NNP
cord-282246-wyanwvxa	166	28	revealed	reveal	VBD
cord-282246-wyanwvxa	166	29	that	that	IN
cord-282246-wyanwvxa	166	30	within	within	IN
cord-282246-wyanwvxa	166	31	this	this	DT
cord-282246-wyanwvxa	166	32	compartment	compartment	NN
cord-282246-wyanwvxa	166	33	(	(	-LRB-
cord-282246-wyanwvxa	166	34	where	where	WRB
cord-282246-wyanwvxa	166	35	RV	rv	NN
cord-282246-wyanwvxa	166	36	replication	replication	NN
cord-282246-wyanwvxa	166	37	predominantly	predominantly	RB
cord-282246-wyanwvxa	166	38	occurs	occur	VBZ
cord-282246-wyanwvxa	166	39	)	)	-RRB-
cord-282246-wyanwvxa	166	40	,	,	,
cord-282246-wyanwvxa	166	41	both	both	CC
cord-282246-wyanwvxa	166	42	infected	infect	VBN
cord-282246-wyanwvxa	166	43	and	and	CC
cord-282246-wyanwvxa	166	44	bystander	bystander	NN
cord-282246-wyanwvxa	166	45	cells	cell	NNS
cord-282246-wyanwvxa	166	46	fail	fail	VBP
cord-282246-wyanwvxa	166	47	to	to	TO
cord-282246-wyanwvxa	166	48	amplify	amplify	VB
cord-282246-wyanwvxa	166	49	the	the	DT
cord-282246-wyanwvxa	166	50	type	type	NN
cord-282246-wyanwvxa	167	1	I	-PRON-	PRP
cord-282246-wyanwvxa	167	2	IFN	IFN	NNP
cord-282246-wyanwvxa	167	3	genes	gene	NNS
cord-282246-wyanwvxa	167	4	[	[	-LRB-
cord-282246-wyanwvxa	167	5	26	26	CD
cord-282246-wyanwvxa	167	6	]	]	-RRB-
cord-282246-wyanwvxa	167	7	.	.	.
cord-282246-wyanwvxa	168	1	In	in	IN
cord-282246-wyanwvxa	168	2	the	the	DT
cord-282246-wyanwvxa	168	3	villous	villous	JJ
cord-282246-wyanwvxa	168	4	epithelium	epithelium	NN
cord-282246-wyanwvxa	168	5	,	,	,
cord-282246-wyanwvxa	168	6	RV	RV	NNP
cord-282246-wyanwvxa	168	7	bystander	bystander	NN
cord-282246-wyanwvxa	168	8	cells	cell	NNS
cord-282246-wyanwvxa	168	9	also	also	RB
cord-282246-wyanwvxa	168	10	do	do	VBP
cord-282246-wyanwvxa	168	11	not	not	RB
cord-282246-wyanwvxa	168	12	express	express	VB
cord-282246-wyanwvxa	168	13	elevated	elevated	JJ
cord-282246-wyanwvxa	168	14	levels	level	NNS
cord-282246-wyanwvxa	168	15	of	of	IN
cord-282246-wyanwvxa	168	16	transcripts	transcript	NNS
cord-282246-wyanwvxa	168	17	encoding	encode	VBG
cord-282246-wyanwvxa	168	18	IRF7	IRF7	NNP
cord-282246-wyanwvxa	168	19	,	,	,
cord-282246-wyanwvxa	168	20	which	which	WDT
cord-282246-wyanwvxa	168	21	is	be	VBZ
cord-282246-wyanwvxa	168	22	upregulated	upregulate	VBN
cord-282246-wyanwvxa	168	23	in	in	IN
cord-282246-wyanwvxa	168	24	response	response	NN
cord-282246-wyanwvxa	168	25	to	to	IN
cord-282246-wyanwvxa	168	26	stimulation	stimulation	NN
cord-282246-wyanwvxa	168	27	of	of	IN
cord-282246-wyanwvxa	168	28	cells	cell	NNS
cord-282246-wyanwvxa	168	29	with	with	IN
cord-282246-wyanwvxa	168	30	secreted	secrete	VBN
cord-282246-wyanwvxa	168	31	IFNs	ifn	NNS
cord-282246-wyanwvxa	168	32	and	and	CC
cord-282246-wyanwvxa	168	33	is	be	VBZ
cord-282246-wyanwvxa	168	34	critical	critical	JJ
cord-282246-wyanwvxa	168	35	for	for	IN
cord-282246-wyanwvxa	168	36	the	the	DT
cord-282246-wyanwvxa	168	37	optimal	optimal	JJ
cord-282246-wyanwvxa	168	38	expression	expression	NN
cord-282246-wyanwvxa	168	39	of	of	IN
cord-282246-wyanwvxa	168	40	several	several	JJ
cord-282246-wyanwvxa	168	41	antiviral	antiviral	JJ
cord-282246-wyanwvxa	168	42	genes	gene	NNS
cord-282246-wyanwvxa	168	43	.	.	.
cord-282246-wyanwvxa	169	1	The	the	DT
cord-282246-wyanwvxa	169	2	effectors	effector	NNS
cord-282246-wyanwvxa	169	3	in	in	IN
cord-282246-wyanwvxa	169	4	RV	rv	NN
cord-282246-wyanwvxa	169	5	-	-	HYPH
cord-282246-wyanwvxa	169	6	infected	infect	VBN
cord-282246-wyanwvxa	169	7	cells	cell	NNS
cord-282246-wyanwvxa	169	8	that	that	WDT
cord-282246-wyanwvxa	169	9	mediate	mediate	VBP
cord-282246-wyanwvxa	169	10	STAT1	stat1	NN
cord-282246-wyanwvxa	169	11	inhibition	inhibition	NN
cord-282246-wyanwvxa	169	12	in	in	IN
cord-282246-wyanwvxa	169	13	bystander	bystander	NN
cord-282246-wyanwvxa	169	14	cells	cell	NNS
cord-282246-wyanwvxa	169	15	and	and	CC
cord-282246-wyanwvxa	169	16	the	the	DT
cord-282246-wyanwvxa	169	17	rotaviral	rotaviral	JJ
cord-282246-wyanwvxa	169	18	factors	factor	NNS
cord-282246-wyanwvxa	169	19	responsible	responsible	JJ
cord-282246-wyanwvxa	169	20	have	have	VBP
cord-282246-wyanwvxa	169	21	not	not	RB
cord-282246-wyanwvxa	169	22	been	be	VBN
cord-282246-wyanwvxa	169	23	identified	identify	VBN
cord-282246-wyanwvxa	169	24	.	.	.
cord-282246-wyanwvxa	170	1	In	in	IN
cord-282246-wyanwvxa	170	2	contrast	contrast	NN
cord-282246-wyanwvxa	170	3	,	,	,
cord-282246-wyanwvxa	170	4	RV	RV	NNP
cord-282246-wyanwvxa	170	5	inhibition	inhibition	NN
cord-282246-wyanwvxa	170	6	of	of	IN
cord-282246-wyanwvxa	170	7	IFNdirected	ifndirecte	VBN
cord-282246-wyanwvxa	170	8	STAT1	stat1	NN
cord-282246-wyanwvxa	170	9	activation	activation	NN
cord-282246-wyanwvxa	170	10	in	in	IN
cord-282246-wyanwvxa	170	11	RV	rv	NN
cord-282246-wyanwvxa	170	12	-	-	HYPH
cord-282246-wyanwvxa	170	13	infected	infect	VBN
cord-282246-wyanwvxa	170	14	cells	cell	NNS
cord-282246-wyanwvxa	170	15	is	be	VBZ
cord-282246-wyanwvxa	170	16	well	well	RB
cord-282246-wyanwvxa	170	17	characterized	characterize	VBN
cord-282246-wyanwvxa	170	18	[	[	-LRB-
cord-282246-wyanwvxa	170	19	26	26	CD
cord-282246-wyanwvxa	170	20	,	,	,
cord-282246-wyanwvxa	170	21	52	52	CD
cord-282246-wyanwvxa	170	22	,	,	,
cord-282246-wyanwvxa	170	23	67	67	CD
cord-282246-wyanwvxa	170	24	]	]	-RRB-
cord-282246-wyanwvxa	170	25	.	.	.
cord-282246-wyanwvxa	171	1	Recent	recent	JJ
cord-282246-wyanwvxa	171	2	findings	finding	NNS
cord-282246-wyanwvxa	171	3	demonstrate	demonstrate	VBP
cord-282246-wyanwvxa	171	4	that	that	IN
cord-282246-wyanwvxa	171	5	at	at	IN
cord-282246-wyanwvxa	171	6	the	the	DT
cord-282246-wyanwvxa	171	7	single	single	JJ
cord-282246-wyanwvxa	171	8	-	-	HYPH
cord-282246-wyanwvxa	171	9	cell	cell	NN
cord-282246-wyanwvxa	171	10	level	level	NN
cord-282246-wyanwvxa	171	11	,	,	,
cord-282246-wyanwvxa	171	12	RV	rv	NN
cord-282246-wyanwvxa	171	13	infection	infection	NN
cord-282246-wyanwvxa	171	14	results	result	VBZ
cord-282246-wyanwvxa	171	15	in	in	IN
cord-282246-wyanwvxa	171	16	the	the	DT
cord-282246-wyanwvxa	171	17	efficient	efficient	JJ
cord-282246-wyanwvxa	171	18	depletion	depletion	NN
cord-282246-wyanwvxa	171	19	of	of	IN
cord-282246-wyanwvxa	171	20	type	type	NN
cord-282246-wyanwvxa	171	21	I	i	NN
cord-282246-wyanwvxa	171	22	,	,	,
cord-282246-wyanwvxa	171	23	II	II	NNP
cord-282246-wyanwvxa	171	24	,	,	,
cord-282246-wyanwvxa	171	25	and	and	CC
cord-282246-wyanwvxa	171	26	III	iii	CD
cord-282246-wyanwvxa	171	27	IFNRs	ifnr	NNS
cord-282246-wyanwvxa	171	28	within	within	IN
cord-282246-wyanwvxa	171	29	RV	RV	NNP
cord-282246-wyanwvxa	171	30	(	(	-LRB-
cord-282246-wyanwvxa	171	31	VP6	VP6	NNP
cord-282246-wyanwvxa	171	32	antigen	antigen	NNP
cord-282246-wyanwvxa	171	33	1	1	CD
cord-282246-wyanwvxa	171	34	)	)	-RRB-
cord-282246-wyanwvxa	171	35	infected	infect	VBN
cord-282246-wyanwvxa	171	36	cells	cell	NNS
cord-282246-wyanwvxa	171	37	[	[	-LRB-
cord-282246-wyanwvxa	171	38	52	52	CD
cord-282246-wyanwvxa	171	39	]	]	-RRB-
cord-282246-wyanwvxa	171	40	.	.	.
cord-282246-wyanwvxa	172	1	Such	such	JJ
cord-282246-wyanwvxa	172	2	RV	rv	NN
cord-282246-wyanwvxa	172	3	-	-	HYPH
cord-282246-wyanwvxa	172	4	mediated	mediate	VBN
cord-282246-wyanwvxa	172	5	IFNR	IFNR	NNP
cord-282246-wyanwvxa	172	6	degradation	degradation	NN
cord-282246-wyanwvxa	172	7	is	be	VBZ
cord-282246-wyanwvxa	172	8	unlikely	unlikely	JJ
cord-282246-wyanwvxa	172	9	to	to	TO
cord-282246-wyanwvxa	172	10	be	be	VB
cord-282246-wyanwvxa	172	11	directed	direct	VBN
cord-282246-wyanwvxa	172	12	by	by	IN
cord-282246-wyanwvxa	172	13	secreted	secrete	VBN
cord-282246-wyanwvxa	172	14	IFNs	ifn	NNS
cord-282246-wyanwvxa	172	15	(	(	-LRB-
cord-282246-wyanwvxa	172	16	i.e.	i.e.	FW
cord-282246-wyanwvxa	172	17	,	,	,
cord-282246-wyanwvxa	172	18	by	by	IN
cord-282246-wyanwvxa	172	19	a	a	DT
cord-282246-wyanwvxa	172	20	ligand	ligand	NN
cord-282246-wyanwvxa	172	21	-	-	HYPH
cord-282246-wyanwvxa	172	22	dependent	dependent	JJ
cord-282246-wyanwvxa	172	23	pathway	pathway	NN
cord-282246-wyanwvxa	172	24	)	)	-RRB-
cord-282246-wyanwvxa	172	25	and	and	CC
cord-282246-wyanwvxa	172	26	despite	despite	IN
cord-282246-wyanwvxa	172	27	prolonged	prolonged	JJ
cord-282246-wyanwvxa	172	28	infection	infection	NN
cord-282246-wyanwvxa	172	29	of	of	IN
cord-282246-wyanwvxa	172	30	cells	cell	NNS
cord-282246-wyanwvxa	172	31	is	be	VBZ
cord-282246-wyanwvxa	172	32	restricted	restrict	VBN
cord-282246-wyanwvxa	172	33	exclusively	exclusively	RB
cord-282246-wyanwvxa	172	34	to	to	IN
cord-282246-wyanwvxa	172	35	the	the	DT
cord-282246-wyanwvxa	172	36	subset	subset	NN
cord-282246-wyanwvxa	172	37	of	of	IN
cord-282246-wyanwvxa	172	38	cells	cell	NNS
cord-282246-wyanwvxa	172	39	expressing	express	VBG
cord-282246-wyanwvxa	172	40	VP6	VP6	NNS
cord-282246-wyanwvxa	172	41	.	.	.
cord-282246-wyanwvxa	173	1	The	the	DT
cord-282246-wyanwvxa	173	2	depletion	depletion	NN
cord-282246-wyanwvxa	173	3	of	of	IN
cord-282246-wyanwvxa	173	4	IFNRs	IFNRs	NNPS
cord-282246-wyanwvxa	173	5	in	in	IN
cord-282246-wyanwvxa	173	6	RV	rv	NN
cord-282246-wyanwvxa	173	7	-	-	HYPH
cord-282246-wyanwvxa	173	8	infected	infect	VBN
cord-282246-wyanwvxa	173	9	cells	cell	NNS
cord-282246-wyanwvxa	173	10	occurs	occur	VBZ
cord-282246-wyanwvxa	173	11	from	from	IN
cord-282246-wyanwvxa	173	12	6	6	CD
cord-282246-wyanwvxa	173	13	to	to	TO
cord-282246-wyanwvxa	173	14	8	8	CD
cord-282246-wyanwvxa	173	15	hours	hour	NNS
cord-282246-wyanwvxa	173	16	postinfection	postinfection	NN
cord-282246-wyanwvxa	173	17	(	(	-LRB-
cord-282246-wyanwvxa	173	18	hpi	hpi	NNP
cord-282246-wyanwvxa	173	19	)	)	-RRB-
cord-282246-wyanwvxa	173	20	onwards	onwards	RB
cord-282246-wyanwvxa	173	21	by	by	IN
cord-282246-wyanwvxa	173	22	a	a	DT
cord-282246-wyanwvxa	173	23	lysosomalÀproteasomal	lysosomalàproteasomal	JJ
cord-282246-wyanwvxa	173	24	pathway	pathway	NN
cord-282246-wyanwvxa	173	25	of	of	IN
cord-282246-wyanwvxa	173	26	protein	protein	NN
cord-282246-wyanwvxa	173	27	degradation	degradation	NN
cord-282246-wyanwvxa	173	28	and	and	CC
cord-282246-wyanwvxa	173	29	is	be	VBZ
cord-282246-wyanwvxa	173	30	not	not	RB
cord-282246-wyanwvxa	173	31	observed	observe	VBN
cord-282246-wyanwvxa	173	32	in	in	IN
cord-282246-wyanwvxa	173	33	the	the	DT
cord-282246-wyanwvxa	173	34	RV	RV	NNP
cord-282246-wyanwvxa	173	35	(	(	-LRB-
cord-282246-wyanwvxa	173	36	VP	VP	NNP
cord-282246-wyanwvxa	173	37	6	6	CD
cord-282246-wyanwvxa	173	38	antigen	antigen	NN
cord-282246-wyanwvxa	173	39	)	)	-RRB-
cord-282246-wyanwvxa	173	40	uninfected	uninfected	JJ
cord-282246-wyanwvxa	173	41	bystander	bystander	NN
cord-282246-wyanwvxa	173	42	cells	cell	NNS
cord-282246-wyanwvxa	173	43	,	,	,
cord-282246-wyanwvxa	173	44	which	which	WDT
cord-282246-wyanwvxa	173	45	are	be	VBP
cord-282246-wyanwvxa	173	46	nevertheless	nevertheless	RB
cord-282246-wyanwvxa	173	47	highly	highly	RB
cord-282246-wyanwvxa	173	48	refractory	refractory	JJ
cord-282246-wyanwvxa	173	49	to	to	IN
cord-282246-wyanwvxa	173	50	IFN	IFN	NNP
cord-282246-wyanwvxa	173	51	-	-	HYPH
cord-282246-wyanwvxa	173	52	directed	direct	VBN
cord-282246-wyanwvxa	173	53	STAT1	stat1	NN
cord-282246-wyanwvxa	173	54	activation	activation	NN
cord-282246-wyanwvxa	173	55	(	(	-LRB-
cord-282246-wyanwvxa	173	56	Fig	Fig	NNP
cord-282246-wyanwvxa	173	57	.	.	.
cord-282246-wyanwvxa	173	58	40.3	40.3	CD
cord-282246-wyanwvxa	173	59	)	)	-RRB-
cord-282246-wyanwvxa	173	60	.	.	.
cord-282246-wyanwvxa	174	1	The	the	DT
cord-282246-wyanwvxa	174	2	relevance	relevance	NN
cord-282246-wyanwvxa	174	3	of	of	IN
cord-282246-wyanwvxa	174	4	RV	rv	NN
cord-282246-wyanwvxa	174	5	-	-	HYPH
cord-282246-wyanwvxa	174	6	mediated	mediate	VBN
cord-282246-wyanwvxa	174	7	IFNR	IFNR	NNP
cord-282246-wyanwvxa	174	8	degradation	degradation	NN
cord-282246-wyanwvxa	174	9	is	be	VBZ
cord-282246-wyanwvxa	174	10	shown	show	VBN
cord-282246-wyanwvxa	174	11	in	in	IN
cord-282246-wyanwvxa	174	12	vivo	vivo	NN
cord-282246-wyanwvxa	174	13	by	by	IN
cord-282246-wyanwvxa	174	14	the	the	DT
cord-282246-wyanwvxa	174	15	significant	significant	JJ
cord-282246-wyanwvxa	174	16	decrease	decrease	NN
cord-282246-wyanwvxa	174	17	in	in	IN
cord-282246-wyanwvxa	174	18	intestinal	intestinal	JJ
cord-282246-wyanwvxa	174	19	type	type	NN
cord-282246-wyanwvxa	174	20	I	-PRON-	PRP
cord-282246-wyanwvxa	174	21	and	and	CC
cord-282246-wyanwvxa	174	22	II	II	NNP
cord-282246-wyanwvxa	174	23	IFNR	IFNR	NNP
cord-282246-wyanwvxa	174	24	protein	protein	NN
cord-282246-wyanwvxa	174	25	expression	expression	NN
cord-282246-wyanwvxa	174	26	in	in	IN
cord-282246-wyanwvxa	174	27	the	the	DT
cord-282246-wyanwvxa	174	28	small	small	JJ
cord-282246-wyanwvxa	174	29	intestine	intestine	NN
cord-282246-wyanwvxa	174	30	following	follow	VBG
cord-282246-wyanwvxa	174	31	murine	murine	JJ
cord-282246-wyanwvxa	174	32	RV	RV	NNP
cord-282246-wyanwvxa	174	33	infection	infection	NN
cord-282246-wyanwvxa	174	34	[	[	-LRB-
cord-282246-wyanwvxa	174	35	52	52	CD
cord-282246-wyanwvxa	174	36	]	]	-RRB-
cord-282246-wyanwvxa	174	37	.	.	.
cord-282246-wyanwvxa	175	1	Degradation	degradation	NN
cord-282246-wyanwvxa	175	2	of	of	IN
cord-282246-wyanwvxa	175	3	different	different	JJ
cord-282246-wyanwvxa	175	4	types	type	NNS
cord-282246-wyanwvxa	175	5	of	of	IN
cord-282246-wyanwvxa	175	6	IFNRs	ifnr	NNS
cord-282246-wyanwvxa	175	7	by	by	IN
cord-282246-wyanwvxa	175	8	RV	RV	NNP
cord-282246-wyanwvxa	175	9	represents	represent	VBZ
cord-282246-wyanwvxa	175	10	an	an	DT
cord-282246-wyanwvxa	175	11	ingenious	ingenious	JJ
cord-282246-wyanwvxa	175	12	strategy	strategy	NN
cord-282246-wyanwvxa	175	13	to	to	TO
cord-282246-wyanwvxa	175	14	ensure	ensure	VB
cord-282246-wyanwvxa	175	15	that	that	IN
cord-282246-wyanwvxa	175	16	any	any	DT
cord-282246-wyanwvxa	175	17	autocrine	autocrine	NN
cord-282246-wyanwvxa	175	18	IFN	IFN	NNP
cord-282246-wyanwvxa	175	19	antiviral	antiviral	JJ
cord-282246-wyanwvxa	175	20	amplification	amplification	NN
cord-282246-wyanwvxa	175	21	is	be	VBZ
cord-282246-wyanwvxa	175	22	inhibited	inhibit	VBN
cord-282246-wyanwvxa	175	23	,	,	,
cord-282246-wyanwvxa	175	24	thus	thus	RB
cord-282246-wyanwvxa	175	25	allowing	allow	VBG
cord-282246-wyanwvxa	175	26	viral	viral	JJ
cord-282246-wyanwvxa	175	27	replication	replication	NN
cord-282246-wyanwvxa	175	28	and	and	CC
cord-282246-wyanwvxa	175	29	cell	cell	NN
cord-282246-wyanwvxa	175	30	to	to	IN
cord-282246-wyanwvxa	175	31	cell	cell	NN
cord-282246-wyanwvxa	175	32	spread	spread	VBN
cord-282246-wyanwvxa	175	33	to	to	TO
cord-282246-wyanwvxa	175	34	proceed	proceed	VB
cord-282246-wyanwvxa	175	35	efficiently	efficiently	RB
cord-282246-wyanwvxa	175	36	[	[	-LRB-
cord-282246-wyanwvxa	175	37	52	52	CD
cord-282246-wyanwvxa	175	38	]	]	-RRB-
cord-282246-wyanwvxa	175	39	.	.	.
cord-282246-wyanwvxa	176	1	Interestingly	interestingly	RB
cord-282246-wyanwvxa	176	2	,	,	,
cord-282246-wyanwvxa	176	3	these	these	DT
cord-282246-wyanwvxa	176	4	findings	finding	NNS
cord-282246-wyanwvxa	176	5	indicate	indicate	VBP
cord-282246-wyanwvxa	176	6	the	the	DT
cord-282246-wyanwvxa	176	7	likelihood	likelihood	NN
cord-282246-wyanwvxa	176	8	that	that	IN
cord-282246-wyanwvxa	176	9	RV	RV	NNP
cord-282246-wyanwvxa	176	10	targets	target	VBZ
cord-282246-wyanwvxa	176	11	a	a	DT
cord-282246-wyanwvxa	176	12	common	common	JJ
cord-282246-wyanwvxa	176	13	hostsignaling	hostsignaling	NN
cord-282246-wyanwvxa	176	14	pathway	pathway	NN
cord-282246-wyanwvxa	176	15	that	that	WDT
cord-282246-wyanwvxa	176	16	is	be	VBZ
cord-282246-wyanwvxa	176	17	responsible	responsible	JJ
cord-282246-wyanwvxa	176	18	for	for	IN
cord-282246-wyanwvxa	176	19	the	the	DT
cord-282246-wyanwvxa	176	20	expression	expression	NN
cord-282246-wyanwvxa	176	21	of	of	IN
cord-282246-wyanwvxa	176	22	all	all	DT
cord-282246-wyanwvxa	176	23	three	three	CD
cord-282246-wyanwvxa	176	24	IFNRs	ifnr	NNS
cord-282246-wyanwvxa	176	25	.	.	.
cord-282246-wyanwvxa	177	1	Continuing	continue	VBG
cord-282246-wyanwvxa	177	2	to	to	TO
cord-282246-wyanwvxa	177	3	unravel	unravel	VB
cord-282246-wyanwvxa	177	4	the	the	DT
cord-282246-wyanwvxa	177	5	mechanisms	mechanism	NNS
cord-282246-wyanwvxa	177	6	by	by	IN
cord-282246-wyanwvxa	177	7	which	which	WDT
cord-282246-wyanwvxa	177	8	RV	RV	NNP
cord-282246-wyanwvxa	177	9	also	also	RB
cord-282246-wyanwvxa	177	10	inhibits	inhibit	VBZ
cord-282246-wyanwvxa	177	11	the	the	DT
cord-282246-wyanwvxa	177	12	response	response	NN
cord-282246-wyanwvxa	177	13	to	to	IN
cord-282246-wyanwvxa	177	14	different	different	JJ
cord-282246-wyanwvxa	177	15	IFNs	ifn	NNS
cord-282246-wyanwvxa	177	16	in	in	IN
cord-282246-wyanwvxa	177	17	bystander	bystander	NN
cord-282246-wyanwvxa	177	18	cells	cell	NNS
cord-282246-wyanwvxa	177	19	is	be	VBZ
cord-282246-wyanwvxa	177	20	important	important	JJ
cord-282246-wyanwvxa	177	21	for	for	IN
cord-282246-wyanwvxa	177	22	several	several	JJ
cord-282246-wyanwvxa	177	23	reasons	reason	NNS
cord-282246-wyanwvxa	177	24	.	.	.
cord-282246-wyanwvxa	178	1	First	first	RB
cord-282246-wyanwvxa	178	2	,	,	,
cord-282246-wyanwvxa	178	3	since	since	IN
cord-282246-wyanwvxa	178	4	the	the	DT
cord-282246-wyanwvxa	178	5	level	level	NN
cord-282246-wyanwvxa	178	6	of	of	IN
cord-282246-wyanwvxa	178	7	RV	rv	NN
cord-282246-wyanwvxa	178	8	replication	replication	NN
cord-282246-wyanwvxa	178	9	substantially	substantially	RB
cord-282246-wyanwvxa	178	10	determines	determine	VBZ
cord-282246-wyanwvxa	178	11	host	host	NN
cord-282246-wyanwvxa	178	12	pathogenicity	pathogenicity	NN
cord-282246-wyanwvxa	178	13	,	,	,
cord-282246-wyanwvxa	178	14	such	such	JJ
cord-282246-wyanwvxa	178	15	information	information	NN
cord-282246-wyanwvxa	178	16	will	will	MD
cord-282246-wyanwvxa	178	17	enable	enable	VB
cord-282246-wyanwvxa	178	18	more	more	RBR
cord-282246-wyanwvxa	178	19	rational	rational	JJ
cord-282246-wyanwvxa	178	20	attenuation	attenuation	NN
cord-282246-wyanwvxa	178	21	of	of	IN
cord-282246-wyanwvxa	178	22	homologous	homologous	JJ
cord-282246-wyanwvxa	178	23	and	and	CC
cord-282246-wyanwvxa	178	24	heterologous	heterologous	JJ
cord-282246-wyanwvxa	178	25	RV	RV	NNP
cord-282246-wyanwvxa	178	26	strains	strain	NNS
cord-282246-wyanwvxa	178	27	and	and	CC
cord-282246-wyanwvxa	178	28	their	-PRON-	PRP$
cord-282246-wyanwvxa	178	29	use	use	NN
cord-282246-wyanwvxa	178	30	as	as	IN
cord-282246-wyanwvxa	178	31	candidate	candidate	NN
cord-282246-wyanwvxa	178	32	thirdgeneration	thirdgeneration	NNP
cord-282246-wyanwvxa	178	33	live	live	VBP
cord-282246-wyanwvxa	178	34	vaccines	vaccine	NNS
cord-282246-wyanwvxa	178	35	.	.	.
cord-282246-wyanwvxa	179	1	Second	second	RB
cord-282246-wyanwvxa	179	2	,	,	,
cord-282246-wyanwvxa	179	3	for	for	IN
cord-282246-wyanwvxa	179	4	several	several	JJ
cord-282246-wyanwvxa	179	5	diseases	disease	NNS
cord-282246-wyanwvxa	179	6	(	(	-LRB-
cord-282246-wyanwvxa	179	7	including	include	VBG
cord-282246-wyanwvxa	179	8	sepsis	sepsis	NN
cord-282246-wyanwvxa	179	9	and	and	CC
cord-282246-wyanwvxa	179	10	systemic	systemic	JJ
cord-282246-wyanwvxa	179	11	lupus	lupus	NN
cord-282246-wyanwvxa	179	12	erythematosus	erythematosus	NN
cord-282246-wyanwvxa	179	13	)	)	-RRB-
cord-282246-wyanwvxa	179	14	,	,	,
cord-282246-wyanwvxa	179	15	an	an	DT
cord-282246-wyanwvxa	179	16	excessive	excessive	JJ
cord-282246-wyanwvxa	179	17	IFN	IFN	NNP
cord-282246-wyanwvxa	179	18	response	response	NN
cord-282246-wyanwvxa	179	19	is	be	VBZ
cord-282246-wyanwvxa	179	20	undesirable	undesirable	JJ
cord-282246-wyanwvxa	179	21	and	and	CC
cord-282246-wyanwvxa	179	22	implicated	implicate	VBN
cord-282246-wyanwvxa	179	23	as	as	IN
cord-282246-wyanwvxa	179	24	a	a	DT
cord-282246-wyanwvxa	179	25	causative	causative	NN
cord-282246-wyanwvxa	179	26	and/or	and/or	CC
cord-282246-wyanwvxa	179	27	exacerbation	exacerbation	NN
cord-282246-wyanwvxa	179	28	trigger	trigger	NN
cord-282246-wyanwvxa	179	29	of	of	IN
cord-282246-wyanwvxa	179	30	disease	disease	NN
cord-282246-wyanwvxa	179	31	.	.	.
cord-282246-wyanwvxa	180	1	In	in	IN
cord-282246-wyanwvxa	180	2	these	these	DT
cord-282246-wyanwvxa	180	3	situations	situation	NNS
cord-282246-wyanwvxa	180	4	,	,	,
cord-282246-wyanwvxa	180	5	discovering	discover	VBG
cord-282246-wyanwvxa	180	6	novel	novel	JJ
cord-282246-wyanwvxa	180	7	therapeutic	therapeutic	JJ
cord-282246-wyanwvxa	180	8	modalities	modality	NNS
cord-282246-wyanwvxa	180	9	that	that	WDT
cord-282246-wyanwvxa	180	10	can	can	MD
cord-282246-wyanwvxa	180	11	dampen	dampen	VB
cord-282246-wyanwvxa	180	12	IFN	IFN	NNP
cord-282246-wyanwvxa	180	13	signaling	signaling	NN
cord-282246-wyanwvxa	180	14	is	be	VBZ
cord-282246-wyanwvxa	180	15	potentially	potentially	RB
cord-282246-wyanwvxa	180	16	valuable	valuable	JJ
cord-282246-wyanwvxa	180	17	.	.	.
cord-282246-wyanwvxa	181	1	Other	other	JJ
cord-282246-wyanwvxa	181	2	RV	RV	NNP
cord-282246-wyanwvxa	181	3	strategies	strategy	NNS
cord-282246-wyanwvxa	181	4	have	have	VBP
cord-282246-wyanwvxa	181	5	also	also	RB
cord-282246-wyanwvxa	181	6	been	be	VBN
cord-282246-wyanwvxa	181	7	identified	identify	VBN
cord-282246-wyanwvxa	181	8	that	that	WDT
cord-282246-wyanwvxa	181	9	are	be	VBP
cord-282246-wyanwvxa	181	10	directed	direct	VBN
cord-282246-wyanwvxa	181	11	at	at	IN
cord-282246-wyanwvxa	181	12	disrupting	disrupt	VBG
cord-282246-wyanwvxa	181	13	STAT1	stat1	NN
cord-282246-wyanwvxa	181	14	signaling	signaling	NN
cord-282246-wyanwvxa	181	15	during	during	IN
cord-282246-wyanwvxa	181	16	infection	infection	NN
cord-282246-wyanwvxa	181	17	.	.	.
cord-282246-wyanwvxa	182	1	The	the	DT
cord-282246-wyanwvxa	182	2	ability	ability	NN
cord-282246-wyanwvxa	182	3	of	of	IN
cord-282246-wyanwvxa	182	4	RV	RV	NNP
cord-282246-wyanwvxa	182	5	to	to	TO
cord-282246-wyanwvxa	182	6	perturb	perturb	VB
cord-282246-wyanwvxa	182	7	STAT1	stat1	NN
cord-282246-wyanwvxa	182	8	signaling	signaling	NN
cord-282246-wyanwvxa	182	9	was	be	VBD
cord-282246-wyanwvxa	182	10	first	first	RB
cord-282246-wyanwvxa	182	11	reported	report	VBN
cord-282246-wyanwvxa	182	12	by	by	IN
cord-282246-wyanwvxa	182	13	Holloway	Holloway	NNP
cord-282246-wyanwvxa	182	14	and	and	CC
cord-282246-wyanwvxa	182	15	colleagues	colleague	NNS
cord-282246-wyanwvxa	182	16	[	[	-LRB-
cord-282246-wyanwvxa	182	17	70	70	CD
cord-282246-wyanwvxa	182	18	,	,	,
cord-282246-wyanwvxa	182	19	71	71	CD
cord-282246-wyanwvxa	182	20	]	]	-RRB-
cord-282246-wyanwvxa	182	21	,	,	,
cord-282246-wyanwvxa	182	22	who	who	WP
cord-282246-wyanwvxa	182	23	observed	observe	VBD
cord-282246-wyanwvxa	182	24	that	that	IN
cord-282246-wyanwvxa	182	25	as	as	RB
cord-282246-wyanwvxa	182	26	early	early	RB
cord-282246-wyanwvxa	182	27	as	as	IN
cord-282246-wyanwvxa	182	28	6	6	CD
cord-282246-wyanwvxa	182	29	hpi	hpi	NNP
cord-282246-wyanwvxa	182	30	,	,	,
cord-282246-wyanwvxa	182	31	several	several	JJ
cord-282246-wyanwvxa	182	32	RV	RV	NNP
cord-282246-wyanwvxa	182	33	strains	strain	NNS
cord-282246-wyanwvxa	182	34	inhibited	inhibit	VBD
cord-282246-wyanwvxa	182	35	the	the	DT
cord-282246-wyanwvxa	182	36	nuclear	nuclear	JJ
cord-282246-wyanwvxa	182	37	translocation	translocation	NN
cord-282246-wyanwvxa	182	38	of	of	IN
cord-282246-wyanwvxa	182	39	phosphorylated	phosphorylated	JJ
cord-282246-wyanwvxa	182	40	STAT1-Y701	STAT1-Y701	NNP
cord-282246-wyanwvxa	182	41	in	in	IN
cord-282246-wyanwvxa	182	42	response	response	NN
cord-282246-wyanwvxa	182	43	to	to	IN
cord-282246-wyanwvxa	182	44	exogenous	exogenous	JJ
cord-282246-wyanwvxa	182	45	IFN	IFN	NNP
cord-282246-wyanwvxa	182	46	stimulation	stimulation	NN
cord-282246-wyanwvxa	182	47	(	(	-LRB-
cord-282246-wyanwvxa	182	48	Fig	Fig	NNP
cord-282246-wyanwvxa	182	49	.	.	.
cord-282246-wyanwvxa	182	50	40.3	40.3	CD
cord-282246-wyanwvxa	182	51	)	)	-RRB-
cord-282246-wyanwvxa	182	52	.	.	.
cord-282246-wyanwvxa	183	1	Although	although	IN
cord-282246-wyanwvxa	183	2	viral	viral	JJ
cord-282246-wyanwvxa	183	3	factors	factor	NNS
cord-282246-wyanwvxa	183	4	responsible	responsible	JJ
cord-282246-wyanwvxa	183	5	for	for	IN
cord-282246-wyanwvxa	183	6	this	this	DT
cord-282246-wyanwvxa	183	7	inhibitory	inhibitory	JJ
cord-282246-wyanwvxa	183	8	effect	effect	NN
cord-282246-wyanwvxa	183	9	downstream	downstream	RB
cord-282246-wyanwvxa	183	10	of	of	IN
cord-282246-wyanwvxa	183	11	STAT1	stat1	NN
cord-282246-wyanwvxa	183	12	activation	activation	NN
cord-282246-wyanwvxa	183	13	have	have	VBP
cord-282246-wyanwvxa	183	14	not	not	RB
cord-282246-wyanwvxa	183	15	yet	yet	RB
cord-282246-wyanwvxa	183	16	been	be	VBN
cord-282246-wyanwvxa	183	17	identified	identify	VBN
cord-282246-wyanwvxa	183	18	,	,	,
cord-282246-wyanwvxa	183	19	it	-PRON-	PRP
cord-282246-wyanwvxa	183	20	is	be	VBZ
cord-282246-wyanwvxa	183	21	possible	possible	JJ
cord-282246-wyanwvxa	183	22	that	that	IN
cord-282246-wyanwvxa	183	23	redundancy	redundancy	NN
cord-282246-wyanwvxa	183	24	in	in	IN
cord-282246-wyanwvxa	183	25	RV	RV	NNP
cord-282246-wyanwvxa	183	26	inhibition	inhibition	NN
cord-282246-wyanwvxa	183	27	of	of	IN
cord-282246-wyanwvxa	183	28	the	the	DT
cord-282246-wyanwvxa	183	29	STAT1	stat1	NN
cord-282246-wyanwvxa	183	30	pathway	pathway	NN
cord-282246-wyanwvxa	183	31	exists	exist	VBZ
cord-282246-wyanwvxa	183	32	,	,	,
cord-282246-wyanwvxa	183	33	perhaps	perhaps	RB
cord-282246-wyanwvxa	183	34	indicative	indicative	JJ
cord-282246-wyanwvxa	183	35	of	of	IN
cord-282246-wyanwvxa	183	36	the	the	DT
cord-282246-wyanwvxa	183	37	vital	vital	JJ
cord-282246-wyanwvxa	183	38	role	role	NN
cord-282246-wyanwvxa	183	39	of	of	IN
cord-282246-wyanwvxa	183	40	inhibiting	inhibit	VBG
cord-282246-wyanwvxa	183	41	IFN	IFN	NNP
cord-282246-wyanwvxa	183	42	signaling	signal	VBG
cord-282246-wyanwvxa	183	43	in	in	IN
cord-282246-wyanwvxa	183	44	enabling	enable	VBG
cord-282246-wyanwvxa	183	45	RV	RV	NNP
cord-282246-wyanwvxa	183	46	replication	replication	NN
cord-282246-wyanwvxa	183	47	.	.	.
cord-282246-wyanwvxa	184	1	The	the	DT
cord-282246-wyanwvxa	184	2	ability	ability	NN
cord-282246-wyanwvxa	184	3	of	of	IN
cord-282246-wyanwvxa	184	4	the	the	DT
cord-282246-wyanwvxa	184	5	RV	RV	NNP
cord-282246-wyanwvxa	184	6	NSP1	NSP1	NNP
cord-282246-wyanwvxa	184	7	protein	protein	NN
cord-282246-wyanwvxa	184	8	to	to	TO
cord-282246-wyanwvxa	184	9	target	target	VB
cord-282246-wyanwvxa	184	10	IRFs	irfs	NN
cord-282246-wyanwvxa	184	11	for	for	IN
cord-282246-wyanwvxa	184	12	proteasomal	proteasomal	JJ
cord-282246-wyanwvxa	184	13	degradation	degradation	NN
cord-282246-wyanwvxa	184	14	extends	extend	VBZ
cord-282246-wyanwvxa	184	15	to	to	IN
cord-282246-wyanwvxa	184	16	IRF7	IRF7	NNP
cord-282246-wyanwvxa	184	17	and	and	CC
cord-282246-wyanwvxa	184	18	IRF9	IRF9	NNP
cord-282246-wyanwvxa	184	19	,	,	,
cord-282246-wyanwvxa	184	20	two	two	CD
cord-282246-wyanwvxa	184	21	additional	additional	JJ
cord-282246-wyanwvxa	184	22	factors	factor	NNS
cord-282246-wyanwvxa	184	23	that	that	WDT
cord-282246-wyanwvxa	184	24	are	be	VBP
cord-282246-wyanwvxa	184	25	critical	critical	JJ
cord-282246-wyanwvxa	184	26	for	for	IN
cord-282246-wyanwvxa	184	27	the	the	DT
cord-282246-wyanwvxa	184	28	optimal	optimal	JJ
cord-282246-wyanwvxa	184	29	amplification	amplification	NN
cord-282246-wyanwvxa	184	30	of	of	IN
cord-282246-wyanwvxa	184	31	IFNdependent	ifndependent	NN
cord-282246-wyanwvxa	184	32	antiviral	antiviral	JJ
cord-282246-wyanwvxa	184	33	responses	response	NNS
cord-282246-wyanwvxa	184	34	[	[	-LRB-
cord-282246-wyanwvxa	184	35	40	40	CD
cord-282246-wyanwvxa	184	36	,	,	,
cord-282246-wyanwvxa	184	37	42	42	CD
cord-282246-wyanwvxa	184	38	]	]	-RRB-
cord-282246-wyanwvxa	184	39	.	.	.
cord-282246-wyanwvxa	185	1	Whereas	whereas	IN
cord-282246-wyanwvxa	185	2	early	early	JJ
cord-282246-wyanwvxa	185	3	induction	induction	NN
cord-282246-wyanwvxa	185	4	of	of	IN
cord-282246-wyanwvxa	185	5	different	different	JJ
cord-282246-wyanwvxa	185	6	IFNs	ifn	NNS
cord-282246-wyanwvxa	185	7	and	and	CC
cord-282246-wyanwvxa	185	8	antiviral	antiviral	JJ
cord-282246-wyanwvxa	185	9	transcripts	transcript	NNS
cord-282246-wyanwvxa	185	10	is	be	VBZ
cord-282246-wyanwvxa	185	11	mediated	mediate	VBN
cord-282246-wyanwvxa	185	12	primarily	primarily	RB
cord-282246-wyanwvxa	185	13	by	by	IN
cord-282246-wyanwvxa	185	14	IRF3	IRF3	NNP
cord-282246-wyanwvxa	185	15	,	,	,
cord-282246-wyanwvxa	185	16	IFNmediated	ifnmediate	VBN
cord-282246-wyanwvxa	186	1	signaling	signal	VBG
cord-282246-wyanwvxa	186	2	results	result	NNS
cord-282246-wyanwvxa	186	3	in	in	IN
cord-282246-wyanwvxa	186	4	an	an	DT
cord-282246-wyanwvxa	186	5	increase	increase	NN
cord-282246-wyanwvxa	186	6	in	in	IN
cord-282246-wyanwvxa	186	7	IRF7	IRF7	NNP
cord-282246-wyanwvxa	186	8	expression	expression	NN
cord-282246-wyanwvxa	186	9	,	,	,
cord-282246-wyanwvxa	186	10	which	which	WDT
cord-282246-wyanwvxa	186	11	subsequently	subsequently	RB
cord-282246-wyanwvxa	186	12	orchestrates	orchestrate	VBZ
cord-282246-wyanwvxa	186	13	the	the	DT
cord-282246-wyanwvxa	186	14	amplification	amplification	NN
cord-282246-wyanwvxa	186	15	of	of	IN
cord-282246-wyanwvxa	186	16	IFNs	ifn	NNS
cord-282246-wyanwvxa	186	17	and	and	CC
cord-282246-wyanwvxa	186	18	of	of	IN
cord-282246-wyanwvxa	186	19	ISGs	isg	NNS
cord-282246-wyanwvxa	186	20	.	.	.
cord-282246-wyanwvxa	187	1	The	the	DT
cord-282246-wyanwvxa	187	2	IFN	IFN	NNP
cord-282246-wyanwvxa	187	3	-	-	HYPH
cord-282246-wyanwvxa	187	4	mediated	mediate	VBN
cord-282246-wyanwvxa	187	5	effects	effect	NNS
cord-282246-wyanwvxa	187	6	on	on	IN
cord-282246-wyanwvxa	187	7	transcription	transcription	NN
cord-282246-wyanwvxa	187	8	of	of	IN
cord-282246-wyanwvxa	187	9	several	several	JJ
cord-282246-wyanwvxa	187	10	genes	gene	NNS
cord-282246-wyanwvxa	187	11	(	(	-LRB-
cord-282246-wyanwvxa	187	12	including	include	VBG
cord-282246-wyanwvxa	187	13	IRF7	IRF7	NNP
cord-282246-wyanwvxa	187	14	)	)	-RRB-
cord-282246-wyanwvxa	187	15	require	require	VBP
cord-282246-wyanwvxa	187	16	the	the	DT
cord-282246-wyanwvxa	187	17	assembly	assembly	NN
cord-282246-wyanwvxa	187	18	of	of	IN
cord-282246-wyanwvxa	187	19	a	a	DT
cord-282246-wyanwvxa	187	20	transcriptional	transcriptional	JJ
cord-282246-wyanwvxa	187	21	complex	complex	NN
cord-282246-wyanwvxa	187	22	ISGF3	isgf3	NN
cord-282246-wyanwvxa	187	23	,	,	,
cord-282246-wyanwvxa	187	24	which	which	WDT
cord-282246-wyanwvxa	187	25	includes	include	VBZ
cord-282246-wyanwvxa	187	26	STAT1	stat1	NN
cord-282246-wyanwvxa	187	27	and	and	CC
cord-282246-wyanwvxa	187	28	IRF9	IRF9	NNP
cord-282246-wyanwvxa	187	29	.	.	.
cord-282246-wyanwvxa	188	1	The	the	DT
cord-282246-wyanwvxa	188	2	role	role	NN
cord-282246-wyanwvxa	188	3	of	of	IN
cord-282246-wyanwvxa	188	4	IRF7	IRF7	NNP
cord-282246-wyanwvxa	188	5	and	and	CC
cord-282246-wyanwvxa	188	6	IRF9	IRF9	NNP
cord-282246-wyanwvxa	188	7	degradation	degradation	NN
cord-282246-wyanwvxa	188	8	in	in	IN
cord-282246-wyanwvxa	188	9	IFN	IFN	NNP
cord-282246-wyanwvxa	188	10	-	-	HYPH
cord-282246-wyanwvxa	188	11	dependent	dependent	JJ
cord-282246-wyanwvxa	188	12	responses	response	NNS
cord-282246-wyanwvxa	188	13	during	during	IN
cord-282246-wyanwvxa	188	14	RV	RV	NNP
cord-282246-wyanwvxa	188	15	infection	infection	NN
cord-282246-wyanwvxa	188	16	has	have	VBZ
cord-282246-wyanwvxa	188	17	not	not	RB
cord-282246-wyanwvxa	188	18	yet	yet	RB
cord-282246-wyanwvxa	188	19	been	be	VBN
cord-282246-wyanwvxa	188	20	well	well	RB
cord-282246-wyanwvxa	188	21	studied	study	VBN
cord-282246-wyanwvxa	188	22	.	.	.
cord-282246-wyanwvxa	189	1	Nevertheless	nevertheless	RB
cord-282246-wyanwvxa	189	2	,	,	,
cord-282246-wyanwvxa	189	3	the	the	DT
cord-282246-wyanwvxa	189	4	degradation	degradation	NN
cord-282246-wyanwvxa	189	5	of	of	IN
cord-282246-wyanwvxa	189	6	IRF7	IRF7	NNP
cord-282246-wyanwvxa	189	7	and	and	CC
cord-282246-wyanwvxa	189	8	IRF9	IRF9	NNP
cord-282246-wyanwvxa	189	9	by	by	IN
cord-282246-wyanwvxa	189	10	NSP1	NSP1	NNP
cord-282246-wyanwvxa	189	11	is	be	VBZ
cord-282246-wyanwvxa	189	12	likely	likely	JJ
cord-282246-wyanwvxa	189	13	to	to	TO
cord-282246-wyanwvxa	189	14	be	be	VB
cord-282246-wyanwvxa	189	15	an	an	DT
cord-282246-wyanwvxa	189	16	additional	additional	JJ
cord-282246-wyanwvxa	189	17	weapon	weapon	NN
cord-282246-wyanwvxa	189	18	in	in	IN
cord-282246-wyanwvxa	189	19	the	the	DT
cord-282246-wyanwvxa	189	20	RV	RV	NNP
cord-282246-wyanwvxa	189	21	arsenal	arsenal	NN
cord-282246-wyanwvxa	189	22	that	that	WDT
cord-282246-wyanwvxa	189	23	can	can	MD
cord-282246-wyanwvxa	189	24	be	be	VB
cord-282246-wyanwvxa	189	25	used	use	VBN
cord-282246-wyanwvxa	189	26	to	to	TO
cord-282246-wyanwvxa	189	27	halt	halt	VB
cord-282246-wyanwvxa	189	28	an	an	DT
cord-282246-wyanwvxa	189	29	efficient	efficient	JJ
cord-282246-wyanwvxa	189	30	IFN	IFN	NNP
cord-282246-wyanwvxa	189	31	amplification	amplification	NN
cord-282246-wyanwvxa	189	32	response	response	NN
cord-282246-wyanwvxa	189	33	(	(	-LRB-
cord-282246-wyanwvxa	189	34	Fig	Fig	NNP
cord-282246-wyanwvxa	189	35	.	.	.
cord-282246-wyanwvxa	189	36	40.3	40.3	CD
cord-282246-wyanwvxa	189	37	)	)	-RRB-
cord-282246-wyanwvxa	189	38	.	.	.
cord-282246-wyanwvxa	190	1	In	in	IN
cord-282246-wyanwvxa	190	2	addition	addition	NN
cord-282246-wyanwvxa	190	3	to	to	IN
cord-282246-wyanwvxa	190	4	the	the	DT
cord-282246-wyanwvxa	190	5	IFN	IFN	NNP
cord-282246-wyanwvxa	190	6	induction	induction	NN
cord-282246-wyanwvxa	190	7	and	and	CC
cord-282246-wyanwvxa	190	8	amplification	amplification	NN
cord-282246-wyanwvxa	190	9	pathway	pathway	NN
cord-282246-wyanwvxa	190	10	,	,	,
cord-282246-wyanwvxa	190	11	RV	RV	NNP
cord-282246-wyanwvxa	190	12	is	be	VBZ
cord-282246-wyanwvxa	190	13	equipped	equip	VBN
cord-282246-wyanwvxa	190	14	with	with	IN
cord-282246-wyanwvxa	190	15	the	the	DT
cord-282246-wyanwvxa	190	16	ability	ability	NN
cord-282246-wyanwvxa	190	17	to	to	TO
cord-282246-wyanwvxa	190	18	block	block	VB
cord-282246-wyanwvxa	190	19	further	further	JJ
cord-282246-wyanwvxa	190	20	downstream	downstream	JJ
cord-282246-wyanwvxa	190	21	effector	effector	NN
cord-282246-wyanwvxa	190	22	antiviral	antiviral	JJ
cord-282246-wyanwvxa	190	23	proteins	protein	NNS
cord-282246-wyanwvxa	190	24	.	.	.
cord-282246-wyanwvxa	191	1	One	one	CD
cord-282246-wyanwvxa	191	2	such	such	JJ
cord-282246-wyanwvxa	191	3	example	example	NN
cord-282246-wyanwvxa	191	4	is	be	VBZ
cord-282246-wyanwvxa	191	5	ribonuclease	ribonuclease	NN
cord-282246-wyanwvxa	191	6	L	L	NNP
cord-282246-wyanwvxa	191	7	(	(	-LRB-
cord-282246-wyanwvxa	191	8	RNaseL	RNaseL	NNP
cord-282246-wyanwvxa	191	9	)	)	-RRB-
cord-282246-wyanwvxa	191	10	,	,	,
cord-282246-wyanwvxa	191	11	a	a	DT
cord-282246-wyanwvxa	191	12	key	key	JJ
cord-282246-wyanwvxa	191	13	enzyme	enzyme	NN
cord-282246-wyanwvxa	191	14	in	in	IN
cord-282246-wyanwvxa	191	15	the	the	DT
cord-282246-wyanwvxa	191	16	IFN	IFN	NNP
cord-282246-wyanwvxa	191	17	-	-	HYPH
cord-282246-wyanwvxa	191	18	inducible	inducible	JJ
cord-282246-wyanwvxa	191	19	2	2	CD
cord-282246-wyanwvxa	191	20	0	0	CD
cord-282246-wyanwvxa	191	21	-5	-5	CD
cord-282246-wyanwvxa	191	22	0	0	CD
cord-282246-wyanwvxa	191	23	-oligoadenylate	-oligoadenylate	NN
cord-282246-wyanwvxa	191	24	synthetase	synthetase	NN
cord-282246-wyanwvxa	191	25	(	(	-LRB-
cord-282246-wyanwvxa	191	26	OAS)-RNaseL	OAS)-RNaseL	NNP
cord-282246-wyanwvxa	191	27	pathway	pathway	NN
cord-282246-wyanwvxa	191	28	responsible	responsible	JJ
cord-282246-wyanwvxa	191	29	for	for	IN
cord-282246-wyanwvxa	191	30	potent	potent	JJ
cord-282246-wyanwvxa	191	31	RNA	RNA	NNP
cord-282246-wyanwvxa	191	32	degradation	degradation	NN
cord-282246-wyanwvxa	191	33	,	,	,
cord-282246-wyanwvxa	191	34	including	include	VBG
cord-282246-wyanwvxa	191	35	both	both	DT
cord-282246-wyanwvxa	191	36	host	host	NN
cord-282246-wyanwvxa	191	37	and	and	CC
cord-282246-wyanwvxa	191	38	viral	viral	JJ
cord-282246-wyanwvxa	191	39	RNA	rna	NN
cord-282246-wyanwvxa	191	40	molecules	molecule	NNS
cord-282246-wyanwvxa	191	41	[	[	-LRB-
cord-282246-wyanwvxa	191	42	72	72	CD
cord-282246-wyanwvxa	191	43	]	]	-RRB-
cord-282246-wyanwvxa	191	44	.	.	.
cord-282246-wyanwvxa	192	1	The	the	DT
cord-282246-wyanwvxa	192	2	RV	RV	NNP
cord-282246-wyanwvxa	192	3	RNA	RNA	NNP
cord-282246-wyanwvxa	192	4	capping	cap	VBG
cord-282246-wyanwvxa	192	5	enzyme	enzyme	NN
cord-282246-wyanwvxa	192	6	VP3	VP3	NNP
cord-282246-wyanwvxa	192	7	encodes	encode	VBZ
cord-282246-wyanwvxa	192	8	a	a	DT
cord-282246-wyanwvxa	192	9	C	c	NN
cord-282246-wyanwvxa	192	10	-	-	HYPH
cord-282246-wyanwvxa	192	11	terminal	terminal	NN
cord-282246-wyanwvxa	192	12	phosphodiesterase	phosphodiesterase	NN
cord-282246-wyanwvxa	192	13	(	(	-LRB-
cord-282246-wyanwvxa	192	14	PDE	PDE	NNP
cord-282246-wyanwvxa	192	15	)	)	-RRB-
cord-282246-wyanwvxa	192	16	domain	domain	NN
cord-282246-wyanwvxa	192	17	that	that	WDT
cord-282246-wyanwvxa	192	18	was	be	VBD
cord-282246-wyanwvxa	192	19	recently	recently	RB
cord-282246-wyanwvxa	192	20	shown	show	VBN
cord-282246-wyanwvxa	192	21	to	to	TO
cord-282246-wyanwvxa	192	22	induce	induce	VB
cord-282246-wyanwvxa	192	23	the	the	DT
cord-282246-wyanwvxa	192	24	degradation	degradation	NN
cord-282246-wyanwvxa	192	25	of	of	IN
cord-282246-wyanwvxa	192	26	2	2	CD
cord-282246-wyanwvxa	192	27	0	0	CD
cord-282246-wyanwvxa	192	28	,	,	,
cord-282246-wyanwvxa	192	29	5	5	CD
cord-282246-wyanwvxa	192	30	0	0	CD
cord-282246-wyanwvxa	192	31	-oligoadenylate	-oligoadenylate	CD
cord-282246-wyanwvxa	192	32	,	,	,
cord-282246-wyanwvxa	192	33	the	the	DT
cord-282246-wyanwvxa	192	34	second	second	JJ
cord-282246-wyanwvxa	192	35	messenger	messenger	NN
cord-282246-wyanwvxa	192	36	responsible	responsible	JJ
cord-282246-wyanwvxa	192	37	for	for	IN
cord-282246-wyanwvxa	192	38	RNaseL	RNaseL	NNP
cord-282246-wyanwvxa	192	39	activation	activation	NN
cord-282246-wyanwvxa	192	40	and	and	CC
cord-282246-wyanwvxa	192	41	dimerization	dimerization	NN
cord-282246-wyanwvxa	192	42	[	[	-LRB-
cord-282246-wyanwvxa	192	43	73	73	CD
cord-282246-wyanwvxa	192	44	]	]	-RRB-
cord-282246-wyanwvxa	192	45	.	.	.
cord-282246-wyanwvxa	193	1	The	the	DT
cord-282246-wyanwvxa	193	2	RV	RV	NNP
cord-282246-wyanwvxa	193	3	VP3	vp3	NN
cord-282246-wyanwvxa	193	4	PDE	PDE	NNP
cord-282246-wyanwvxa	193	5	domain	domain	NN
cord-282246-wyanwvxa	193	6	functionally	functionally	RB
cord-282246-wyanwvxa	193	7	replaced	replace	VBD
cord-282246-wyanwvxa	193	8	the	the	DT
cord-282246-wyanwvxa	193	9	comparable	comparable	JJ
cord-282246-wyanwvxa	193	10	domain	domain	NN
cord-282246-wyanwvxa	193	11	in	in	IN
cord-282246-wyanwvxa	193	12	the	the	DT
cord-282246-wyanwvxa	193	13	murine	murine	JJ
cord-282246-wyanwvxa	193	14	coronavirus	coronavirus	NN
cord-282246-wyanwvxa	193	15	ns2	ns2	CD
cord-282246-wyanwvxa	193	16	protein	protein	NN
cord-282246-wyanwvxa	193	17	and	and	CC
cord-282246-wyanwvxa	193	18	inhibited	inhibit	VBD
cord-282246-wyanwvxa	193	19	RNaseL	rnasel	JJ
cord-282246-wyanwvxa	193	20	activity	activity	NN
cord-282246-wyanwvxa	193	21	.	.	.
cord-282246-wyanwvxa	194	1	A	a	DT
cord-282246-wyanwvxa	194	2	more	more	RBR
cord-282246-wyanwvxa	194	3	recent	recent	JJ
cord-282246-wyanwvxa	194	4	study	study	NN
cord-282246-wyanwvxa	194	5	suggests	suggest	VBZ
cord-282246-wyanwvxa	194	6	that	that	IN
cord-282246-wyanwvxa	194	7	another	another	DT
cord-282246-wyanwvxa	194	8	VP3-independent	vp3-independent	NN
cord-282246-wyanwvxa	194	9	,	,	,
cord-282246-wyanwvxa	194	10	yet	yet	RB
cord-282246-wyanwvxa	194	11	-	-	HYPH
cord-282246-wyanwvxa	194	12	to	to	TO
cord-282246-wyanwvxa	194	13	-	-	HYPH
cord-282246-wyanwvxa	194	14	be	be	VB
cord-282246-wyanwvxa	194	15	identified	identify	VBN
cord-282246-wyanwvxa	194	16	,	,	,
cord-282246-wyanwvxa	194	17	mechanism	mechanism	NN
cord-282246-wyanwvxa	194	18	also	also	RB
cord-282246-wyanwvxa	194	19	exists	exist	VBZ
cord-282246-wyanwvxa	194	20	and	and	CC
cord-282246-wyanwvxa	194	21	contributes	contribute	VBZ
cord-282246-wyanwvxa	194	22	to	to	IN
cord-282246-wyanwvxa	194	23	RV	RV	NNP
cord-282246-wyanwvxa	194	24	inhibition	inhibition	NN
cord-282246-wyanwvxa	194	25	of	of	IN
cord-282246-wyanwvxa	194	26	RNaseL	RNaseL	NNP
cord-282246-wyanwvxa	194	27	[	[	-LRB-
cord-282246-wyanwvxa	194	28	74	74	CD
cord-282246-wyanwvxa	194	29	]	]	-RRB-
cord-282246-wyanwvxa	194	30	.	.	.
cord-282246-wyanwvxa	195	1	However	however	RB
cord-282246-wyanwvxa	195	2	,	,	,
cord-282246-wyanwvxa	195	3	the	the	DT
cord-282246-wyanwvxa	195	4	actual	actual	JJ
cord-282246-wyanwvxa	195	5	physiological	physiological	JJ
cord-282246-wyanwvxa	195	6	roles	role	NNS
cord-282246-wyanwvxa	195	7	of	of	IN
cord-282246-wyanwvxa	195	8	RNaseL	RNaseL	NNP
cord-282246-wyanwvxa	195	9	in	in	IN
cord-282246-wyanwvxa	195	10	modulating	modulate	VBG
cord-282246-wyanwvxa	195	11	RV	RV	NNP
cord-282246-wyanwvxa	195	12	replication	replication	NN
cord-282246-wyanwvxa	195	13	and	and	CC
cord-282246-wyanwvxa	195	14	of	of	IN
cord-282246-wyanwvxa	195	15	VP3	VP3	NNP
cord-282246-wyanwvxa	195	16	in	in	IN
cord-282246-wyanwvxa	195	17	antagonizing	antagonize	VBG
cord-282246-wyanwvxa	195	18	RNaseL	RNaseL	NNP
cord-282246-wyanwvxa	195	19	in	in	IN
cord-282246-wyanwvxa	195	20	vivo	vivo	NN
cord-282246-wyanwvxa	195	21	remain	remain	VBP
cord-282246-wyanwvxa	195	22	to	to	TO
cord-282246-wyanwvxa	195	23	be	be	VB
cord-282246-wyanwvxa	195	24	demonstrated	demonstrate	VBN
cord-282246-wyanwvxa	195	25	.	.	.
cord-282246-wyanwvxa	196	1	There	there	EX
cord-282246-wyanwvxa	196	2	are	be	VBP
cord-282246-wyanwvxa	196	3	currently	currently	RB
cord-282246-wyanwvxa	196	4	two	two	CD
cord-282246-wyanwvxa	196	5	time	time	NN
cord-282246-wyanwvxa	196	6	-	-	HYPH
cord-282246-wyanwvxa	196	7	honored	honor	VBN
cord-282246-wyanwvxa	196	8	and	and	CC
cord-282246-wyanwvxa	196	9	demonstrably	demonstrably	RB
cord-282246-wyanwvxa	196	10	successful	successful	JJ
cord-282246-wyanwvxa	196	11	approaches	approach	NNS
cord-282246-wyanwvxa	196	12	to	to	IN
cord-282246-wyanwvxa	196	13	developing	develop	VBG
cord-282246-wyanwvxa	196	14	safe	safe	JJ
cord-282246-wyanwvxa	196	15	and	and	CC
cord-282246-wyanwvxa	196	16	effective	effective	JJ
cord-282246-wyanwvxa	196	17	human	human	JJ
cord-282246-wyanwvxa	196	18	viral	viral	JJ
cord-282246-wyanwvxa	196	19	vaccines	vaccine	NNS
cord-282246-wyanwvxa	196	20	[	[	-LRB-
cord-282246-wyanwvxa	196	21	75	75	CD
cord-282246-wyanwvxa	196	22	]	]	-RRB-
cord-282246-wyanwvxa	196	23	.	.	.
cord-282246-wyanwvxa	197	1	In	in	IN
cord-282246-wyanwvxa	197	2	the	the	DT
cord-282246-wyanwvxa	197	3	first	first	JJ
cord-282246-wyanwvxa	197	4	case	case	NN
cord-282246-wyanwvxa	197	5	,	,	,
cord-282246-wyanwvxa	197	6	a	a	DT
cord-282246-wyanwvxa	197	7	wide	wide	JJ
cord-282246-wyanwvxa	197	8	variety	variety	NN
cord-282246-wyanwvxa	197	9	of	of	IN
cord-282246-wyanwvxa	197	10	current	current	JJ
cord-282246-wyanwvxa	197	11	viral	viral	JJ
cord-282246-wyanwvxa	197	12	vaccines	vaccine	NNS
cord-282246-wyanwvxa	197	13	rely	rely	VBP
cord-282246-wyanwvxa	197	14	on	on	IN
cord-282246-wyanwvxa	197	15	the	the	DT
cord-282246-wyanwvxa	197	16	parenteral	parenteral	JJ
cord-282246-wyanwvxa	197	17	administration	administration	NN
cord-282246-wyanwvxa	197	18	of	of	IN
cord-282246-wyanwvxa	197	19	replication	replication	NN
cord-282246-wyanwvxa	197	20	-	-	HYPH
cord-282246-wyanwvxa	197	21	incompetent	incompetent	JJ
cord-282246-wyanwvxa	197	22	inactivated	inactivate	VBN
cord-282246-wyanwvxa	197	23	whole	whole	JJ
cord-282246-wyanwvxa	197	24	virus	virus	NN
cord-282246-wyanwvxa	197	25	,	,	,
cord-282246-wyanwvxa	197	26	the	the	DT
cord-282246-wyanwvxa	197	27	parenteral	parenteral	JJ
cord-282246-wyanwvxa	197	28	administration	administration	NN
cord-282246-wyanwvxa	197	29	of	of	IN
cord-282246-wyanwvxa	197	30	a	a	DT
cord-282246-wyanwvxa	197	31	viral	viral	JJ
cord-282246-wyanwvxa	197	32	protein(s	protein(s	NNP
cord-282246-wyanwvxa	197	33	)	)	-RRB-
cord-282246-wyanwvxa	197	34	component	component	NN
cord-282246-wyanwvxa	197	35	,	,	,
cord-282246-wyanwvxa	197	36	or	or	CC
cord-282246-wyanwvxa	197	37	the	the	DT
cord-282246-wyanwvxa	197	38	administration	administration	NN
cord-282246-wyanwvxa	197	39	a	a	DT
cord-282246-wyanwvxa	197	40	molecularly	molecularly	RB
cord-282246-wyanwvxa	197	41	produced	produce	VBN
cord-282246-wyanwvxa	197	42	virus	virus	NN
cord-282246-wyanwvxa	197	43	-	-	HYPH
cord-282246-wyanwvxa	197	44	like	like	JJ
cord-282246-wyanwvxa	197	45	particle	particle	NN
cord-282246-wyanwvxa	197	46	(	(	-LRB-
cord-282246-wyanwvxa	197	47	VLP	VLP	NNP
cord-282246-wyanwvxa	197	48	)	)	-RRB-
cord-282246-wyanwvxa	197	49	.	.	.
cord-282246-wyanwvxa	198	1	All	all	DT
cord-282246-wyanwvxa	198	2	of	of	IN
cord-282246-wyanwvxa	198	3	these	these	DT
cord-282246-wyanwvxa	198	4	entities	entity	NNS
cord-282246-wyanwvxa	198	5	are	be	VBP
cord-282246-wyanwvxa	198	6	selected	select	VBN
cord-282246-wyanwvxa	198	7	because	because	IN
cord-282246-wyanwvxa	198	8	immunity	immunity	NN
cord-282246-wyanwvxa	198	9	to	to	IN
cord-282246-wyanwvxa	198	10	the	the	DT
cord-282246-wyanwvxa	198	11	individual	individual	JJ
cord-282246-wyanwvxa	198	12	protein	protein	NN
cord-282246-wyanwvxa	198	13	,	,	,
cord-282246-wyanwvxa	198	14	inactivated	inactivate	VBD
cord-282246-wyanwvxa	198	15	whole	whole	JJ
cord-282246-wyanwvxa	198	16	virus	virus	NN
cord-282246-wyanwvxa	198	17	,	,	,
cord-282246-wyanwvxa	198	18	or	or	CC
cord-282246-wyanwvxa	198	19	VLP	VLP	NNP
cord-282246-wyanwvxa	198	20	induces	induce	VBZ
cord-282246-wyanwvxa	198	21	protective	protective	JJ
cord-282246-wyanwvxa	198	22	immunity	immunity	NN
cord-282246-wyanwvxa	198	23	to	to	IN
cord-282246-wyanwvxa	198	24	the	the	DT
cord-282246-wyanwvxa	198	25	host	host	NN
cord-282246-wyanwvxa	198	26	and	and	CC
cord-282246-wyanwvxa	198	27	,	,	,
cord-282246-wyanwvxa	198	28	at	at	IN
cord-282246-wyanwvxa	198	29	the	the	DT
cord-282246-wyanwvxa	198	30	same	same	JJ
cord-282246-wyanwvxa	198	31	time	time	NN
cord-282246-wyanwvxa	198	32	,	,	,
cord-282246-wyanwvxa	198	33	is	be	VBZ
cord-282246-wyanwvxa	198	34	both	both	DT
cord-282246-wyanwvxa	198	35	safe	safe	JJ
cord-282246-wyanwvxa	198	36	and	and	CC
cord-282246-wyanwvxa	198	37	well	well	RB
cord-282246-wyanwvxa	198	38	tolerated	tolerate	VBN
cord-282246-wyanwvxa	198	39	.	.	.
cord-282246-wyanwvxa	199	1	There	there	EX
cord-282246-wyanwvxa	199	2	are	be	VBP
cord-282246-wyanwvxa	199	3	numerous	numerous	JJ
cord-282246-wyanwvxa	199	4	highly	highly	RB
cord-282246-wyanwvxa	199	5	successful	successful	JJ
cord-282246-wyanwvxa	199	6	examples	example	NNS
cord-282246-wyanwvxa	199	7	of	of	IN
cord-282246-wyanwvxa	199	8	this	this	DT
cord-282246-wyanwvxa	199	9	category	category	NN
cord-282246-wyanwvxa	199	10	of	of	IN
cord-282246-wyanwvxa	199	11	viral	viral	JJ
cord-282246-wyanwvxa	199	12	vaccine	vaccine	NN
cord-282246-wyanwvxa	199	13	(	(	-LRB-
cord-282246-wyanwvxa	199	14	e.g.	e.g.	RB
cord-282246-wyanwvxa	199	15	,	,	,
cord-282246-wyanwvxa	199	16	the	the	DT
cord-282246-wyanwvxa	199	17	inactivated	inactivated	JJ
cord-282246-wyanwvxa	199	18	polio	polio	NN
cord-282246-wyanwvxa	199	19	vaccine	vaccine	NN
cord-282246-wyanwvxa	199	20	,	,	,
cord-282246-wyanwvxa	199	21	the	the	DT
cord-282246-wyanwvxa	199	22	various	various	JJ
cord-282246-wyanwvxa	199	23	preparations	preparation	NNS
cord-282246-wyanwvxa	199	24	of	of	IN
cord-282246-wyanwvxa	199	25	inactivated	inactivate	VBN
cord-282246-wyanwvxa	199	26	influenza	influenza	NN
cord-282246-wyanwvxa	199	27	hemagglutinin	hemagglutinin	NN
cord-282246-wyanwvxa	199	28	-	-	HYPH
cord-282246-wyanwvxa	199	29	based	base	VBN
cord-282246-wyanwvxa	199	30	vaccines	vaccine	NNS
cord-282246-wyanwvxa	199	31	,	,	,
cord-282246-wyanwvxa	199	32	the	the	DT
cord-282246-wyanwvxa	199	33	human	human	JJ
cord-282246-wyanwvxa	199	34	papilloma	papilloma	NN
cord-282246-wyanwvxa	199	35	VLP	VLP	NNP
cord-282246-wyanwvxa	199	36	vaccine	vaccine	NN
cord-282246-wyanwvxa	199	37	,	,	,
cord-282246-wyanwvxa	199	38	the	the	DT
cord-282246-wyanwvxa	199	39	hepatitis	hepatitis	NN
cord-282246-wyanwvxa	199	40	B	B	NNP
cord-282246-wyanwvxa	199	41	virus	virus	NN
cord-282246-wyanwvxa	199	42	vaccine	vaccine	NN
cord-282246-wyanwvxa	199	43	,	,	,
cord-282246-wyanwvxa	199	44	and	and	CC
cord-282246-wyanwvxa	199	45	the	the	DT
cord-282246-wyanwvxa	199	46	recently	recently	RB
cord-282246-wyanwvxa	199	47	licensed	license	VBN
cord-282246-wyanwvxa	199	48	herpes	herpes	NNP
cord-282246-wyanwvxa	199	49	zoster	zoster	NNP
cord-282246-wyanwvxa	199	50	gE	gE	NNP
cord-282246-wyanwvxa	199	51	protein	protein	NN
cord-282246-wyanwvxa	199	52	-	-	HYPH
cord-282246-wyanwvxa	199	53	based	base	VBN
cord-282246-wyanwvxa	199	54	vaccine	vaccine	NN
cord-282246-wyanwvxa	199	55	)	)	-RRB-
cord-282246-wyanwvxa	199	56	.	.	.
cord-282246-wyanwvxa	200	1	In	in	IN
cord-282246-wyanwvxa	200	2	all	all	DT
cord-282246-wyanwvxa	200	3	cases	case	NNS
cord-282246-wyanwvxa	200	4	,	,	,
cord-282246-wyanwvxa	200	5	these	these	DT
cord-282246-wyanwvxa	200	6	vaccines	vaccine	NNS
cord-282246-wyanwvxa	200	7	are	be	VBP
cord-282246-wyanwvxa	200	8	administered	administer	VBN
cord-282246-wyanwvxa	200	9	parenterally	parenterally	RB
cord-282246-wyanwvxa	200	10	.	.	.
cord-282246-wyanwvxa	201	1	Several	several	JJ
cord-282246-wyanwvxa	201	2	are	be	VBP
cord-282246-wyanwvxa	201	3	administered	administer	VBN
cord-282246-wyanwvxa	201	4	with	with	IN
cord-282246-wyanwvxa	201	5	adjuvants	adjuvant	NNS
cord-282246-wyanwvxa	201	6	of	of	IN
cord-282246-wyanwvxa	201	7	one	one	CD
cord-282246-wyanwvxa	201	8	kind	kind	NN
cord-282246-wyanwvxa	201	9	or	or	CC
cord-282246-wyanwvxa	201	10	another	another	DT
cord-282246-wyanwvxa	201	11	to	to	TO
cord-282246-wyanwvxa	201	12	enhance	enhance	VB
cord-282246-wyanwvxa	201	13	immune	immune	JJ
cord-282246-wyanwvxa	201	14	responses	response	NNS
cord-282246-wyanwvxa	201	15	,	,	,
cord-282246-wyanwvxa	201	16	and	and	CC
cord-282246-wyanwvxa	201	17	in	in	IN
cord-282246-wyanwvxa	201	18	all	all	DT
cord-282246-wyanwvxa	201	19	cases	case	NNS
cord-282246-wyanwvxa	201	20	,	,	,
cord-282246-wyanwvxa	201	21	they	-PRON-	PRP
cord-282246-wyanwvxa	201	22	appear	appear	VBP
cord-282246-wyanwvxa	201	23	to	to	TO
cord-282246-wyanwvxa	201	24	function	function	VB
cord-282246-wyanwvxa	201	25	primarily	primarily	RB
cord-282246-wyanwvxa	201	26	by	by	IN
cord-282246-wyanwvxa	201	27	stimulating	stimulate	VBG
cord-282246-wyanwvxa	201	28	systemic	systemic	JJ
cord-282246-wyanwvxa	201	29	immunity	immunity	NN
cord-282246-wyanwvxa	201	30	,	,	,
cord-282246-wyanwvxa	201	31	with	with	IN
cord-282246-wyanwvxa	201	32	the	the	DT
cord-282246-wyanwvxa	201	33	primary	primary	JJ
cord-282246-wyanwvxa	201	34	effector	effector	NN
cord-282246-wyanwvxa	201	35	function	function	NN
cord-282246-wyanwvxa	201	36	generally	generally	RB
cord-282246-wyanwvxa	201	37	mediated	mediate	VBN
cord-282246-wyanwvxa	201	38	by	by	IN
cord-282246-wyanwvxa	201	39	systemic	systemic	JJ
cord-282246-wyanwvxa	201	40	antibodies	antibody	NNS
cord-282246-wyanwvxa	201	41	.	.	.
cord-282246-wyanwvxa	202	1	Of	of	IN
cord-282246-wyanwvxa	202	2	note	note	NN
cord-282246-wyanwvxa	202	3	,	,	,
cord-282246-wyanwvxa	202	4	none	none	NN
cord-282246-wyanwvxa	202	5	of	of	IN
cord-282246-wyanwvxa	202	6	these	these	DT
cord-282246-wyanwvxa	202	7	types	type	NNS
cord-282246-wyanwvxa	202	8	of	of	IN
cord-282246-wyanwvxa	202	9	vaccines	vaccine	NNS
cord-282246-wyanwvxa	202	10	are	be	VBP
cord-282246-wyanwvxa	202	11	directed	direct	VBN
cord-282246-wyanwvxa	202	12	at	at	IN
cord-282246-wyanwvxa	202	13	a	a	DT
cord-282246-wyanwvxa	202	14	predominantly	predominantly	RB
cord-282246-wyanwvxa	202	15	enteric	enteric	JJ
cord-282246-wyanwvxa	202	16	pathogen	pathogen	NN
cord-282246-wyanwvxa	202	17	,	,	,
cord-282246-wyanwvxa	202	18	although	although	IN
cord-282246-wyanwvxa	202	19	an	an	DT
cord-282246-wyanwvxa	202	20	investigation	investigation	NN
cord-282246-wyanwvxa	202	21	of	of	IN
cord-282246-wyanwvxa	202	22	a	a	DT
cord-282246-wyanwvxa	202	23	potential	potential	JJ
cord-282246-wyanwvxa	202	24	parenterally	parenterally	NN
cord-282246-wyanwvxa	202	25	administered	administer	VBN
cord-282246-wyanwvxa	202	26	norovirus	norovirus	NN
cord-282246-wyanwvxa	202	27	VLP	VLP	NNP
cord-282246-wyanwvxa	202	28	vaccine	vaccine	NN
cord-282246-wyanwvxa	202	29	is	be	VBZ
cord-282246-wyanwvxa	202	30	currently	currently	RB
cord-282246-wyanwvxa	202	31	under	under	IN
cord-282246-wyanwvxa	202	32	way	way	NN
cord-282246-wyanwvxa	202	33	[	[	-LRB-
cord-282246-wyanwvxa	202	34	76	76	CD
cord-282246-wyanwvxa	202	35	]	]	-RRB-
cord-282246-wyanwvxa	202	36	,	,	,
cord-282246-wyanwvxa	202	37	and	and	CC
cord-282246-wyanwvxa	202	38	there	there	EX
cord-282246-wyanwvxa	202	39	are	be	VBP
cord-282246-wyanwvxa	202	40	plans	plan	NNS
cord-282246-wyanwvxa	202	41	to	to	TO
cord-282246-wyanwvxa	202	42	study	study	VB
cord-282246-wyanwvxa	202	43	the	the	DT
cord-282246-wyanwvxa	202	44	utility	utility	NN
cord-282246-wyanwvxa	202	45	of	of	IN
cord-282246-wyanwvxa	202	46	a	a	DT
cord-282246-wyanwvxa	202	47	heat	heat	NN
cord-282246-wyanwvxa	202	48	-	-	HYPH
cord-282246-wyanwvxa	202	49	inactivated	inactivate	VBN
cord-282246-wyanwvxa	202	50	RV	RV	NNP
cord-282246-wyanwvxa	202	51	virion	virion	NN
cord-282246-wyanwvxa	202	52	-	-	HYPH
cord-282246-wyanwvxa	202	53	based	base	VBN
cord-282246-wyanwvxa	202	54	vaccine	vaccine	NN
cord-282246-wyanwvxa	202	55	in	in	IN
cord-282246-wyanwvxa	202	56	humans	human	NNS
cord-282246-wyanwvxa	202	57	[	[	-LRB-
cord-282246-wyanwvxa	202	58	77	77	CD
cord-282246-wyanwvxa	202	59	]	]	-RRB-
cord-282246-wyanwvxa	202	60	.	.	.
cord-282246-wyanwvxa	203	1	The	the	DT
cord-282246-wyanwvxa	203	2	greatest	great	JJS
cord-282246-wyanwvxa	203	3	advantages	advantage	NNS
cord-282246-wyanwvxa	203	4	of	of	IN
cord-282246-wyanwvxa	203	5	the	the	DT
cord-282246-wyanwvxa	203	6	inactivated	inactivate	VBN
cord-282246-wyanwvxa	203	7	/	/	SYM
cord-282246-wyanwvxa	203	8	recombinant	recombinant	JJ
cord-282246-wyanwvxa	203	9	protein	protein	NN
cord-282246-wyanwvxa	203	10	-	-	HYPH
cord-282246-wyanwvxa	203	11	based	base	VBN
cord-282246-wyanwvxa	203	12	vaccines	vaccine	NNS
cord-282246-wyanwvxa	203	13	are	be	VBP
cord-282246-wyanwvxa	203	14	their	-PRON-	PRP$
cord-282246-wyanwvxa	203	15	general	general	JJ
cord-282246-wyanwvxa	203	16	safety	safety	NN
cord-282246-wyanwvxa	203	17	and	and	CC
cord-282246-wyanwvxa	203	18	the	the	DT
cord-282246-wyanwvxa	203	19	fact	fact	NN
cord-282246-wyanwvxa	203	20	that	that	IN
cord-282246-wyanwvxa	203	21	they	-PRON-	PRP
cord-282246-wyanwvxa	203	22	can	can	MD
cord-282246-wyanwvxa	203	23	be	be	VB
cord-282246-wyanwvxa	203	24	produced	produce	VBN
cord-282246-wyanwvxa	203	25	even	even	RB
cord-282246-wyanwvxa	203	26	when	when	WRB
cord-282246-wyanwvxa	203	27	the	the	DT
cord-282246-wyanwvxa	203	28	actual	actual	JJ
cord-282246-wyanwvxa	203	29	pathogen	pathogen	NN
cord-282246-wyanwvxa	203	30	can	can	MD
cord-282246-wyanwvxa	203	31	not	not	RB
cord-282246-wyanwvxa	203	32	be	be	VB
cord-282246-wyanwvxa	203	33	readily	readily	RB
cord-282246-wyanwvxa	203	34	propagated	propagate	VBN
cord-282246-wyanwvxa	203	35	.	.	.
cord-282246-wyanwvxa	204	1	The	the	DT
cord-282246-wyanwvxa	204	2	general	general	JJ
cord-282246-wyanwvxa	204	3	disadvantage	disadvantage	NN
cord-282246-wyanwvxa	204	4	of	of	IN
cord-282246-wyanwvxa	204	5	such	such	JJ
cord-282246-wyanwvxa	204	6	vaccines	vaccine	NNS
cord-282246-wyanwvxa	204	7	is	be	VBZ
cord-282246-wyanwvxa	204	8	that	that	IN
cord-282246-wyanwvxa	204	9	they	-PRON-	PRP
cord-282246-wyanwvxa	204	10	are	be	VBP
cord-282246-wyanwvxa	204	11	almost	almost	RB
cord-282246-wyanwvxa	204	12	always	always	RB
cord-282246-wyanwvxa	204	13	less	less	RBR
cord-282246-wyanwvxa	204	14	effective	effective	JJ
cord-282246-wyanwvxa	204	15	at	at	IN
cord-282246-wyanwvxa	204	16	stimulating	stimulate	VBG
cord-282246-wyanwvxa	204	17	T	t	NN
cord-282246-wyanwvxa	204	18	-	-	HYPH
cord-282246-wyanwvxa	204	19	cell	cell	NN
cord-282246-wyanwvxa	204	20	-	-	HYPH
cord-282246-wyanwvxa	204	21	based	base	VBN
cord-282246-wyanwvxa	204	22	immune	immune	JJ
cord-282246-wyanwvxa	204	23	responses	response	NNS
cord-282246-wyanwvxa	204	24	,	,	,
cord-282246-wyanwvxa	204	25	they	-PRON-	PRP
cord-282246-wyanwvxa	204	26	are	be	VBP
cord-282246-wyanwvxa	204	27	not	not	RB
cord-282246-wyanwvxa	204	28	very	very	RB
cord-282246-wyanwvxa	204	29	efficient	efficient	JJ
cord-282246-wyanwvxa	204	30	at	at	IN
cord-282246-wyanwvxa	204	31	stimulating	stimulate	VBG
cord-282246-wyanwvxa	204	32	mucosal	mucosal	JJ
cord-282246-wyanwvxa	204	33	immune	immune	JJ
cord-282246-wyanwvxa	204	34	responses	response	NNS
cord-282246-wyanwvxa	204	35	,	,	,
cord-282246-wyanwvxa	204	36	that	that	IN
cord-282246-wyanwvxa	204	37	highly	highly	RB
cord-282246-wyanwvxa	204	38	effective	effective	JJ
cord-282246-wyanwvxa	204	39	mucosal	mucosal	JJ
cord-282246-wyanwvxa	204	40	immune	immune	JJ
cord-282246-wyanwvxa	204	41	adjuvants	adjuvant	NNS
cord-282246-wyanwvxa	204	42	are	be	VBP
cord-282246-wyanwvxa	204	43	not	not	RB
cord-282246-wyanwvxa	204	44	yet	yet	RB
cord-282246-wyanwvxa	204	45	readily	readily	RB
cord-282246-wyanwvxa	204	46	available	available	JJ
cord-282246-wyanwvxa	204	47	,	,	,
cord-282246-wyanwvxa	204	48	and	and	CC
cord-282246-wyanwvxa	204	49	in	in	IN
cord-282246-wyanwvxa	204	50	some	some	DT
cord-282246-wyanwvxa	204	51	cases	case	NNS
cord-282246-wyanwvxa	204	52	,	,	,
cord-282246-wyanwvxa	204	53	immune	immune	JJ
cord-282246-wyanwvxa	204	54	responses	response	NNS
cord-282246-wyanwvxa	204	55	to	to	IN
cord-282246-wyanwvxa	204	56	these	these	DT
cord-282246-wyanwvxa	204	57	inactivated	inactivate	VBN
cord-282246-wyanwvxa	204	58	vaccine	vaccine	NN
cord-282246-wyanwvxa	204	59	preparations	preparation	NNS
cord-282246-wyanwvxa	204	60	tend	tend	VBP
cord-282246-wyanwvxa	204	61	to	to	TO
cord-282246-wyanwvxa	204	62	diminish	diminish	VB
cord-282246-wyanwvxa	204	63	over	over	IN
cord-282246-wyanwvxa	204	64	time	time	NN
cord-282246-wyanwvxa	204	65	more	more	RBR
cord-282246-wyanwvxa	204	66	rapidly	rapidly	RB
cord-282246-wyanwvxa	204	67	than	than	IN
cord-282246-wyanwvxa	204	68	do	do	VB
cord-282246-wyanwvxa	204	69	responses	response	NNS
cord-282246-wyanwvxa	204	70	to	to	IN
cord-282246-wyanwvxa	204	71	several	several	JJ
cord-282246-wyanwvxa	204	72	live	live	JJ
cord-282246-wyanwvxa	204	73	viral	viral	JJ
cord-282246-wyanwvxa	204	74	vaccines	vaccine	NNS
cord-282246-wyanwvxa	204	75	.	.	.
cord-282246-wyanwvxa	205	1	Other	other	JJ
cord-282246-wyanwvxa	205	2	potential	potential	JJ
cord-282246-wyanwvxa	205	3	disadvantages	disadvantage	NNS
cord-282246-wyanwvxa	205	4	of	of	IN
cord-282246-wyanwvxa	205	5	inactivated	inactivate	VBN
cord-282246-wyanwvxa	205	6	vaccines	vaccine	NNS
cord-282246-wyanwvxa	205	7	become	become	VBP
cord-282246-wyanwvxa	205	8	apparent	apparent	JJ
cord-282246-wyanwvxa	205	9	when	when	WRB
cord-282246-wyanwvxa	205	10	the	the	DT
cord-282246-wyanwvxa	205	11	antigen	antigen	NN
cord-282246-wyanwvxa	205	12	or	or	CC
cord-282246-wyanwvxa	205	13	antigens	antigen	NNS
cord-282246-wyanwvxa	205	14	required	require	VBN
cord-282246-wyanwvxa	205	15	to	to	TO
cord-282246-wyanwvxa	205	16	induce	induce	VB
cord-282246-wyanwvxa	205	17	protective	protective	JJ
cord-282246-wyanwvxa	205	18	immunity	immunity	NN
cord-282246-wyanwvxa	205	19	are	be	VBP
cord-282246-wyanwvxa	205	20	difficult	difficult	JJ
cord-282246-wyanwvxa	205	21	to	to	TO
cord-282246-wyanwvxa	205	22	synthesize	synthesize	VB
cord-282246-wyanwvxa	205	23	artificially	artificially	RB
cord-282246-wyanwvxa	205	24	or	or	CC
cord-282246-wyanwvxa	205	25	when	when	WRB
cord-282246-wyanwvxa	205	26	immunity	immunity	NN
cord-282246-wyanwvxa	205	27	is	be	VBZ
cord-282246-wyanwvxa	205	28	most	most	RBS
cord-282246-wyanwvxa	205	29	potent	potent	JJ
cord-282246-wyanwvxa	205	30	when	when	WRB
cord-282246-wyanwvxa	205	31	it	-PRON-	PRP
cord-282246-wyanwvxa	205	32	is	be	VBZ
cord-282246-wyanwvxa	205	33	directed	direct	VBN
cord-282246-wyanwvxa	205	34	at	at	IN
cord-282246-wyanwvxa	205	35	multiple	multiple	JJ
cord-282246-wyanwvxa	205	36	antigens	antigen	NNS
cord-282246-wyanwvxa	205	37	that	that	WDT
cord-282246-wyanwvxa	205	38	are	be	VBP
cord-282246-wyanwvxa	205	39	correctly	correctly	RB
cord-282246-wyanwvxa	205	40	folded	fold	VBN
cord-282246-wyanwvxa	205	41	only	only	RB
cord-282246-wyanwvxa	205	42	on	on	IN
cord-282246-wyanwvxa	205	43	the	the	DT
cord-282246-wyanwvxa	205	44	actual	actual	JJ
cord-282246-wyanwvxa	205	45	or	or	CC
cord-282246-wyanwvxa	205	46	recombinant	recombinant	JJ
cord-282246-wyanwvxa	205	47	multiprotein	multiprotein	NNP
cord-282246-wyanwvxa	205	48	viral	viral	JJ
cord-282246-wyanwvxa	205	49	particle	particle	NN
cord-282246-wyanwvxa	205	50	.	.	.
cord-282246-wyanwvxa	206	1	Of	of	IN
cord-282246-wyanwvxa	206	2	note	note	NN
cord-282246-wyanwvxa	206	3	,	,	,
cord-282246-wyanwvxa	206	4	RVs	rv	NNS
cord-282246-wyanwvxa	206	5	have	have	VBP
cord-282246-wyanwvxa	206	6	at	at	RB
cord-282246-wyanwvxa	206	7	least	least	RBS
cord-282246-wyanwvxa	206	8	two	two	CD
cord-282246-wyanwvxa	206	9	separate	separate	JJ
cord-282246-wyanwvxa	206	10	proteins	protein	NNS
cord-282246-wyanwvxa	206	11	(	(	-LRB-
cord-282246-wyanwvxa	206	12	VP4	VP4	NNP
cord-282246-wyanwvxa	206	13	and	and	CC
cord-282246-wyanwvxa	206	14	VP7	VP7	NNP
cord-282246-wyanwvxa	206	15	)	)	-RRB-
cord-282246-wyanwvxa	206	16	that	that	WDT
cord-282246-wyanwvxa	206	17	are	be	VBP
cord-282246-wyanwvxa	206	18	targets	target	NNS
cord-282246-wyanwvxa	206	19	of	of	IN
cord-282246-wyanwvxa	206	20	protective	protective	JJ
cord-282246-wyanwvxa	206	21	antibodies	antibody	NNS
cord-282246-wyanwvxa	206	22	,	,	,
cord-282246-wyanwvxa	206	23	and	and	CC
cord-282246-wyanwvxa	206	24	VP4	VP4	NNP
cord-282246-wyanwvxa	206	25	is	be	VBZ
cord-282246-wyanwvxa	206	26	cleaved	cleave	VBN
cord-282246-wyanwvxa	206	27	by	by	IN
cord-282246-wyanwvxa	206	28	enteric	enteric	JJ
cord-282246-wyanwvxa	206	29	trypsin	trypsin	NN
cord-282246-wyanwvxa	206	30	into	into	IN
cord-282246-wyanwvxa	206	31	two	two	CD
cord-282246-wyanwvxa	206	32	separate	separate	JJ
cord-282246-wyanwvxa	206	33	protein	protein	NN
cord-282246-wyanwvxa	206	34	components	component	NNS
cord-282246-wyanwvxa	206	35	:	:	:
cord-282246-wyanwvxa	206	36	VP8	VP8	NNP
cord-282246-wyanwvxa	206	37	*	*	NFP
cord-282246-wyanwvxa	206	38	and	and	CC
cord-282246-wyanwvxa	206	39	VP5	VP5	NNS
cord-282246-wyanwvxa	206	40	*	*	NFP
cord-282246-wyanwvxa	206	41	[	[	-LRB-
cord-282246-wyanwvxa	206	42	78	78	CD
cord-282246-wyanwvxa	206	43	]	]	-RRB-
cord-282246-wyanwvxa	206	44	.	.	.
cord-282246-wyanwvxa	207	1	Both	both	DT
cord-282246-wyanwvxa	207	2	VP8	VP8	NNP
cord-282246-wyanwvxa	207	3	*	*	NFP
cord-282246-wyanwvxa	207	4	and	and	CC
cord-282246-wyanwvxa	207	5	VP5	VP5	NNS
cord-282246-wyanwvxa	207	6	*	*	NFP
cord-282246-wyanwvxa	207	7	are	be	VBP
cord-282246-wyanwvxa	207	8	individually	individually	RB
cord-282246-wyanwvxa	207	9	targeted	target	VBN
cord-282246-wyanwvxa	207	10	by	by	IN
cord-282246-wyanwvxa	207	11	protective	protective	JJ
cord-282246-wyanwvxa	207	12	antibody	antibody	NN
cord-282246-wyanwvxa	207	13	responses	response	NNS
cord-282246-wyanwvxa	207	14	.	.	.
cord-282246-wyanwvxa	208	1	VP7	VP7	NNP
cord-282246-wyanwvxa	208	2	is	be	VBZ
cord-282246-wyanwvxa	208	3	correctly	correctly	RB
cord-282246-wyanwvxa	208	4	folded	fold	VBN
cord-282246-wyanwvxa	208	5	into	into	IN
cord-282246-wyanwvxa	208	6	its	-PRON-	PRP$
cord-282246-wyanwvxa	208	7	proper	proper	JJ
cord-282246-wyanwvxa	208	8	antigenic	antigenic	JJ
cord-282246-wyanwvxa	208	9	trimeric	trimeric	NN
cord-282246-wyanwvxa	208	10	form	form	NN
cord-282246-wyanwvxa	208	11	only	only	RB
cord-282246-wyanwvxa	208	12	within	within	IN
cord-282246-wyanwvxa	208	13	the	the	DT
cord-282246-wyanwvxa	208	14	context	context	NN
cord-282246-wyanwvxa	208	15	of	of	IN
cord-282246-wyanwvxa	208	16	the	the	DT
cord-282246-wyanwvxa	208	17	RV	RV	NNP
cord-282246-wyanwvxa	208	18	virion	virion	NN
cord-282246-wyanwvxa	208	19	,	,	,
cord-282246-wyanwvxa	208	20	and	and	CC
cord-282246-wyanwvxa	208	21	a	a	DT
cord-282246-wyanwvxa	208	22	similar	similar	JJ
cord-282246-wyanwvxa	208	23	issue	issue	NN
cord-282246-wyanwvxa	208	24	likely	likely	RB
cord-282246-wyanwvxa	208	25	is	be	VBZ
cord-282246-wyanwvxa	208	26	true	true	JJ
cord-282246-wyanwvxa	208	27	for	for	IN
cord-282246-wyanwvxa	208	28	VP5	VP5	NNS
cord-282246-wyanwvxa	209	1	*	*	NFP
cord-282246-wyanwvxa	209	2	.	.	.
cord-282246-wyanwvxa	210	1	On	on	IN
cord-282246-wyanwvxa	210	2	the	the	DT
cord-282246-wyanwvxa	210	3	other	other	JJ
cord-282246-wyanwvxa	210	4	hand	hand	NN
cord-282246-wyanwvxa	210	5	,	,	,
cord-282246-wyanwvxa	210	6	the	the	DT
cord-282246-wyanwvxa	210	7	RV	RV	NNP
cord-282246-wyanwvxa	210	8	VP8	vp8	NN
cord-282246-wyanwvxa	210	9	*	*	NFP
cord-282246-wyanwvxa	210	10	protein	protein	NN
cord-282246-wyanwvxa	210	11	can	can	MD
cord-282246-wyanwvxa	210	12	be	be	VB
cord-282246-wyanwvxa	210	13	relatively	relatively	RB
cord-282246-wyanwvxa	210	14	simply	simply	RB
cord-282246-wyanwvxa	210	15	and	and	CC
cord-282246-wyanwvxa	210	16	accurately	accurately	RB
cord-282246-wyanwvxa	210	17	synthesized	synthesize	VBN
cord-282246-wyanwvxa	210	18	in	in	IN
cord-282246-wyanwvxa	210	19	several	several	JJ
cord-282246-wyanwvxa	210	20	prokaryote	prokaryote	NN
cord-282246-wyanwvxa	210	21	and	and	CC
cord-282246-wyanwvxa	210	22	eukaryote	eukaryote	NN
cord-282246-wyanwvxa	210	23	systems	system	NNS
cord-282246-wyanwvxa	210	24	,	,	,
cord-282246-wyanwvxa	210	25	and	and	CC
cord-282246-wyanwvxa	210	26	because	because	IN
cord-282246-wyanwvxa	210	27	of	of	IN
cord-282246-wyanwvxa	210	28	this	this	DT
cord-282246-wyanwvxa	210	29	feature	feature	NN
cord-282246-wyanwvxa	210	30	,	,	,
cord-282246-wyanwvxa	210	31	it	-PRON-	PRP
cord-282246-wyanwvxa	210	32	is	be	VBZ
cord-282246-wyanwvxa	210	33	currently	currently	RB
cord-282246-wyanwvxa	210	34	being	be	VBG
cord-282246-wyanwvxa	210	35	examined	examine	VBN
cord-282246-wyanwvxa	210	36	as	as	IN
cord-282246-wyanwvxa	210	37	a	a	DT
cord-282246-wyanwvxa	210	38	potential	potential	JJ
cord-282246-wyanwvxa	210	39	inactivated	inactivate	VBN
cord-282246-wyanwvxa	210	40	vaccine	vaccine	NN
cord-282246-wyanwvxa	210	41	to	to	TO
cord-282246-wyanwvxa	210	42	be	be	VB
cord-282246-wyanwvxa	210	43	administered	administer	VBN
cord-282246-wyanwvxa	210	44	parenterally	parenterally	RB
cord-282246-wyanwvxa	210	45	[	[	-LRB-
cord-282246-wyanwvxa	210	46	79	79	CD
cord-282246-wyanwvxa	210	47	]	]	-RRB-
cord-282246-wyanwvxa	211	1	(	(	-LRB-
cord-282246-wyanwvxa	211	2	Chapter	chapter	NN
cord-282246-wyanwvxa	211	3	41	41	CD
cord-282246-wyanwvxa	211	4	:	:	:
cord-282246-wyanwvxa	211	5	Development	development	NN
cord-282246-wyanwvxa	211	6	of	of	IN
cord-282246-wyanwvxa	211	7	Oral	Oral	NNP
cord-282246-wyanwvxa	211	8	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	211	9	&	&	CC
cord-282246-wyanwvxa	211	10	Norovirus	Norovirus	NNP
cord-282246-wyanwvxa	211	11	Vaccines	Vaccines	NNPS
cord-282246-wyanwvxa	211	12	)	)	-RRB-
cord-282246-wyanwvxa	211	13	.	.	.
cord-282246-wyanwvxa	212	1	The	the	DT
cord-282246-wyanwvxa	212	2	second	second	JJ
cord-282246-wyanwvxa	212	3	highly	highly	RB
cord-282246-wyanwvxa	212	4	successful	successful	JJ
cord-282246-wyanwvxa	212	5	approach	approach	NN
cord-282246-wyanwvxa	212	6	to	to	IN
cord-282246-wyanwvxa	212	7	human	human	JJ
cord-282246-wyanwvxa	212	8	viral	viral	JJ
cord-282246-wyanwvxa	212	9	vaccine	vaccine	NN
cord-282246-wyanwvxa	212	10	development	development	NN
cord-282246-wyanwvxa	212	11	has	have	VBZ
cord-282246-wyanwvxa	212	12	been	be	VBN
cord-282246-wyanwvxa	212	13	the	the	DT
cord-282246-wyanwvxa	212	14	production	production	NN
cord-282246-wyanwvxa	212	15	of	of	IN
cord-282246-wyanwvxa	212	16	live	live	JJ
cord-282246-wyanwvxa	212	17	attenuated	attenuated	JJ
cord-282246-wyanwvxa	212	18	viral	viral	JJ
cord-282246-wyanwvxa	212	19	vaccines	vaccine	NNS
cord-282246-wyanwvxa	212	20	that	that	WDT
cord-282246-wyanwvxa	212	21	actually	actually	RB
cord-282246-wyanwvxa	212	22	infect	infect	VBP
cord-282246-wyanwvxa	212	23	susceptible	susceptible	JJ
cord-282246-wyanwvxa	212	24	people	people	NNS
cord-282246-wyanwvxa	212	25	but	but	CC
cord-282246-wyanwvxa	212	26	are	be	VBP
cord-282246-wyanwvxa	212	27	attenuated	attenuate	VBN
cord-282246-wyanwvxa	212	28	to	to	IN
cord-282246-wyanwvxa	212	29	such	such	PDT
cord-282246-wyanwvxa	212	30	a	a	DT
cord-282246-wyanwvxa	212	31	degree	degree	NN
cord-282246-wyanwvxa	212	32	that	that	IN
cord-282246-wyanwvxa	212	33	their	-PRON-	PRP$
cord-282246-wyanwvxa	212	34	level	level	NN
cord-282246-wyanwvxa	212	35	of	of	IN
cord-282246-wyanwvxa	212	36	reactogenicity	reactogenicity	NN
cord-282246-wyanwvxa	212	37	and	and	CC
cord-282246-wyanwvxa	212	38	pathogenicity	pathogenicity	NN
cord-282246-wyanwvxa	212	39	is	be	VBZ
cord-282246-wyanwvxa	212	40	acceptable	acceptable	JJ
cord-282246-wyanwvxa	212	41	,	,	,
cord-282246-wyanwvxa	212	42	while	while	IN
cord-282246-wyanwvxa	212	43	they	-PRON-	PRP
cord-282246-wyanwvxa	212	44	reliably	reliably	RB
cord-282246-wyanwvxa	212	45	generate	generate	VBP
cord-282246-wyanwvxa	212	46	protective	protective	JJ
cord-282246-wyanwvxa	212	47	immunity	immunity	NN
cord-282246-wyanwvxa	212	48	.	.	.
cord-282246-wyanwvxa	213	1	As	as	IN
cord-282246-wyanwvxa	213	2	with	with	IN
cord-282246-wyanwvxa	213	3	inactivated	inactivate	VBN
cord-282246-wyanwvxa	213	4	vaccines	vaccine	NNS
cord-282246-wyanwvxa	213	5	,	,	,
cord-282246-wyanwvxa	213	6	a	a	DT
cord-282246-wyanwvxa	213	7	number	number	NN
cord-282246-wyanwvxa	213	8	of	of	IN
cord-282246-wyanwvxa	213	9	highly	highly	RB
cord-282246-wyanwvxa	213	10	effective	effective	JJ
cord-282246-wyanwvxa	213	11	replication	replication	NN
cord-282246-wyanwvxa	213	12	-	-	HYPH
cord-282246-wyanwvxa	213	13	competent	competent	JJ
cord-282246-wyanwvxa	213	14	viral	viral	JJ
cord-282246-wyanwvxa	213	15	vaccines	vaccine	NNS
cord-282246-wyanwvxa	213	16	are	be	VBP
cord-282246-wyanwvxa	213	17	currently	currently	RB
cord-282246-wyanwvxa	213	18	available	available	JJ
cord-282246-wyanwvxa	213	19	(	(	-LRB-
cord-282246-wyanwvxa	213	20	e.g.	e.g.	RB
cord-282246-wyanwvxa	213	21	,	,	,
cord-282246-wyanwvxa	213	22	oral	oral	JJ
cord-282246-wyanwvxa	213	23	Sabin	Sabin	NNP
cord-282246-wyanwvxa	213	24	polio	polio	NN
cord-282246-wyanwvxa	213	25	vaccine	vaccine	NN
cord-282246-wyanwvxa	213	26	,	,	,
cord-282246-wyanwvxa	213	27	measles	measles	NN
cord-282246-wyanwvxa	213	28	vaccine	vaccine	NN
cord-282246-wyanwvxa	213	29	,	,	,
cord-282246-wyanwvxa	213	30	rubella	rubella	NN
cord-282246-wyanwvxa	213	31	vaccine	vaccine	NN
cord-282246-wyanwvxa	213	32	,	,	,
cord-282246-wyanwvxa	213	33	yellow	yellow	JJ
cord-282246-wyanwvxa	213	34	fever	fever	NN
cord-282246-wyanwvxa	213	35	vaccine	vaccine	NN
cord-282246-wyanwvxa	213	36	,	,	,
cord-282246-wyanwvxa	213	37	smallpox	smallpox	NN
cord-282246-wyanwvxa	213	38	vaccine	vaccine	NN
cord-282246-wyanwvxa	213	39	,	,	,
cord-282246-wyanwvxa	213	40	live	live	VBP
cord-282246-wyanwvxa	213	41	attenuated	attenuated	JJ
cord-282246-wyanwvxa	213	42	influenza	influenza	NN
cord-282246-wyanwvxa	213	43	vaccine	vaccine	NN
cord-282246-wyanwvxa	213	44	,	,	,
cord-282246-wyanwvxa	213	45	and	and	CC
cord-282246-wyanwvxa	213	46	,	,	,
cord-282246-wyanwvxa	213	47	of	of	IN
cord-282246-wyanwvxa	213	48	course	course	NN
cord-282246-wyanwvxa	213	49	,	,	,
cord-282246-wyanwvxa	213	50	several	several	JJ
cord-282246-wyanwvxa	213	51	licensed	license	VBN
cord-282246-wyanwvxa	213	52	RV	RV	NNP
cord-282246-wyanwvxa	213	53	vaccines	vaccine	NNS
cord-282246-wyanwvxa	213	54	,	,	,
cord-282246-wyanwvxa	213	55	such	such	JJ
cord-282246-wyanwvxa	213	56	as	as	IN
cord-282246-wyanwvxa	213	57	RotaTeq	RotaTeq	NNP
cord-282246-wyanwvxa	213	58	,	,	,
cord-282246-wyanwvxa	213	59	Rotarix	Rotarix	NNP
cord-282246-wyanwvxa	213	60	,	,	,
cord-282246-wyanwvxa	213	61	and	and	CC
cord-282246-wyanwvxa	213	62	Rotavac	Rotavac	NNP
cord-282246-wyanwvxa	213	63	)	)	-RRB-
cord-282246-wyanwvxa	213	64	[	[	-LRB-
cord-282246-wyanwvxa	213	65	75	75	CD
cord-282246-wyanwvxa	213	66	]	]	-RRB-
cord-282246-wyanwvxa	213	67	.	.	.
cord-282246-wyanwvxa	214	1	Most	Most	JJS
cord-282246-wyanwvxa	214	2	but	but	CC
cord-282246-wyanwvxa	214	3	not	not	RB
cord-282246-wyanwvxa	214	4	all	all	DT
cord-282246-wyanwvxa	214	5	of	of	IN
cord-282246-wyanwvxa	214	6	the	the	DT
cord-282246-wyanwvxa	214	7	live	live	JJ
cord-282246-wyanwvxa	214	8	attenuated	attenuated	JJ
cord-282246-wyanwvxa	214	9	viral	viral	JJ
cord-282246-wyanwvxa	214	10	vaccines	vaccine	NNS
cord-282246-wyanwvxa	214	11	are	be	VBP
cord-282246-wyanwvxa	214	12	administered	administer	VBN
cord-282246-wyanwvxa	214	13	by	by	IN
cord-282246-wyanwvxa	214	14	parenteral	parenteral	JJ
cord-282246-wyanwvxa	214	15	injection	injection	NN
cord-282246-wyanwvxa	214	16	;	;	:
cord-282246-wyanwvxa	214	17	however	however	RB
cord-282246-wyanwvxa	214	18	,	,	,
cord-282246-wyanwvxa	214	19	oral	oral	JJ
cord-282246-wyanwvxa	214	20	polio	polio	NN
cord-282246-wyanwvxa	214	21	,	,	,
cord-282246-wyanwvxa	214	22	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	214	23	,	,	,
cord-282246-wyanwvxa	214	24	and	and	CC
cord-282246-wyanwvxa	214	25	live	live	VB
cord-282246-wyanwvxa	214	26	attenuated	attenuated	JJ
cord-282246-wyanwvxa	214	27	influenza	influenza	NN
cord-282246-wyanwvxa	214	28	vaccine	vaccine	NN
cord-282246-wyanwvxa	214	29	are	be	VBP
cord-282246-wyanwvxa	214	30	all	all	DT
cord-282246-wyanwvxa	214	31	administered	administer	VBN
cord-282246-wyanwvxa	214	32	to	to	IN
cord-282246-wyanwvxa	214	33	a	a	DT
cord-282246-wyanwvxa	214	34	mucosal	mucosal	JJ
cord-282246-wyanwvxa	214	35	surface	surface	NN
cord-282246-wyanwvxa	214	36	(	(	-LRB-
cord-282246-wyanwvxa	214	37	the	the	DT
cord-282246-wyanwvxa	214	38	GI	GI	NNP
cord-282246-wyanwvxa	214	39	tract	tract	NN
cord-282246-wyanwvxa	214	40	and	and	CC
cord-282246-wyanwvxa	214	41	the	the	DT
cord-282246-wyanwvxa	214	42	respiratory	respiratory	JJ
cord-282246-wyanwvxa	214	43	tract	tract	NN
cord-282246-wyanwvxa	214	44	,	,	,
cord-282246-wyanwvxa	214	45	respectively	respectively	RB
cord-282246-wyanwvxa	214	46	)	)	-RRB-
cord-282246-wyanwvxa	214	47	.	.	.
cord-282246-wyanwvxa	215	1	The	the	DT
cord-282246-wyanwvxa	215	2	general	general	JJ
cord-282246-wyanwvxa	215	3	thinking	thinking	NN
cord-282246-wyanwvxa	215	4	is	be	VBZ
cord-282246-wyanwvxa	215	5	that	that	IN
cord-282246-wyanwvxa	215	6	live	live	JJ
cord-282246-wyanwvxa	215	7	attenuated	attenuated	JJ
cord-282246-wyanwvxa	215	8	viral	viral	JJ
cord-282246-wyanwvxa	215	9	vaccines	vaccine	NNS
cord-282246-wyanwvxa	215	10	more	more	RBR
cord-282246-wyanwvxa	215	11	closely	closely	RB
cord-282246-wyanwvxa	215	12	mimic	mimic	VBP
cord-282246-wyanwvxa	215	13	the	the	DT
cord-282246-wyanwvxa	215	14	type	type	NN
cord-282246-wyanwvxa	215	15	and	and	CC
cord-282246-wyanwvxa	215	16	level	level	NN
cord-282246-wyanwvxa	215	17	of	of	IN
cord-282246-wyanwvxa	215	18	immunity	immunity	NN
cord-282246-wyanwvxa	215	19	induced	induce	VBN
cord-282246-wyanwvxa	215	20	by	by	IN
cord-282246-wyanwvxa	215	21	natural	natural	JJ
cord-282246-wyanwvxa	215	22	infection	infection	NN
cord-282246-wyanwvxa	215	23	than	than	IN
cord-282246-wyanwvxa	215	24	parenterally	parenterally	RB
cord-282246-wyanwvxa	215	25	administered	administer	VBN
cord-282246-wyanwvxa	215	26	inactivated	inactivate	VBN
cord-282246-wyanwvxa	215	27	vaccines	vaccine	NNS
cord-282246-wyanwvxa	215	28	do	do	VBP
cord-282246-wyanwvxa	215	29	.	.	.
cord-282246-wyanwvxa	216	1	If	if	IN
cord-282246-wyanwvxa	216	2	natural	natural	JJ
cord-282246-wyanwvxa	216	3	infection	infection	NN
cord-282246-wyanwvxa	216	4	is	be	VBZ
cord-282246-wyanwvxa	216	5	an	an	DT
cord-282246-wyanwvxa	216	6	effective	effective	JJ
cord-282246-wyanwvxa	216	7	preventative	preventative	NN
cord-282246-wyanwvxa	216	8	of	of	IN
cord-282246-wyanwvxa	216	9	severe	severe	JJ
cord-282246-wyanwvxa	216	10	secondary	secondary	JJ
cord-282246-wyanwvxa	216	11	infection	infection	NN
cord-282246-wyanwvxa	216	12	,	,	,
cord-282246-wyanwvxa	216	13	then	then	RB
cord-282246-wyanwvxa	216	14	reproducing	reproduce	VBG
cord-282246-wyanwvxa	216	15	it	-PRON-	PRP
cord-282246-wyanwvxa	216	16	without	without	IN
cord-282246-wyanwvxa	216	17	undue	undue	JJ
cord-282246-wyanwvxa	216	18	reactogenicity	reactogenicity	NN
cord-282246-wyanwvxa	216	19	can	can	MD
cord-282246-wyanwvxa	216	20	be	be	VB
cord-282246-wyanwvxa	216	21	desirable	desirable	JJ
cord-282246-wyanwvxa	216	22	.	.	.
cord-282246-wyanwvxa	217	1	This	this	DT
cord-282246-wyanwvxa	217	2	feature	feature	NN
cord-282246-wyanwvxa	217	3	is	be	VBZ
cord-282246-wyanwvxa	217	4	present	present	JJ
cord-282246-wyanwvxa	217	5	when	when	WRB
cord-282246-wyanwvxa	217	6	natural	natural	JJ
cord-282246-wyanwvxa	217	7	immunity	immunity	NN
cord-282246-wyanwvxa	217	8	is	be	VBZ
cord-282246-wyanwvxa	217	9	operative	operative	JJ
cord-282246-wyanwvxa	217	10	primarily	primarily	RB
cord-282246-wyanwvxa	217	11	at	at	IN
cord-282246-wyanwvxa	217	12	a	a	DT
cord-282246-wyanwvxa	217	13	mucosal	mucosal	JJ
cord-282246-wyanwvxa	217	14	surface	surface	NN
cord-282246-wyanwvxa	217	15	,	,	,
cord-282246-wyanwvxa	217	16	as	as	IN
cord-282246-wyanwvxa	217	17	is	be	VBZ
cord-282246-wyanwvxa	217	18	the	the	DT
cord-282246-wyanwvxa	217	19	case	case	NN
cord-282246-wyanwvxa	217	20	for	for	IN
cord-282246-wyanwvxa	217	21	RVs	rv	NNS
cord-282246-wyanwvxa	217	22	.	.	.
cord-282246-wyanwvxa	218	1	Natural	natural	JJ
cord-282246-wyanwvxa	218	2	RV	RV	NNP
cord-282246-wyanwvxa	218	3	infection	infection	NN
cord-282246-wyanwvxa	218	4	efficiently	efficiently	RB
cord-282246-wyanwvxa	218	5	protects	protect	VBZ
cord-282246-wyanwvxa	218	6	against	against	IN
cord-282246-wyanwvxa	218	7	severe	severe	JJ
cord-282246-wyanwvxa	218	8	reinfection	reinfection	NN
cord-282246-wyanwvxa	218	9	,	,	,
cord-282246-wyanwvxa	218	10	and	and	CC
cord-282246-wyanwvxa	218	11	for	for	IN
cord-282246-wyanwvxa	218	12	this	this	DT
cord-282246-wyanwvxa	218	13	reason	reason	NN
cord-282246-wyanwvxa	218	14	,	,	,
cord-282246-wyanwvxa	218	15	a	a	DT
cord-282246-wyanwvxa	218	16	variety	variety	NN
cord-282246-wyanwvxa	218	17	of	of	IN
cord-282246-wyanwvxa	218	18	experimental	experimental	JJ
cord-282246-wyanwvxa	218	19	and	and	CC
cord-282246-wyanwvxa	218	20	licensed	license	VBD
cord-282246-wyanwvxa	218	21	live	live	JJ
cord-282246-wyanwvxa	218	22	attenuated	attenuated	JJ
cord-282246-wyanwvxa	218	23	RV	RV	NNP
cord-282246-wyanwvxa	218	24	vaccines	vaccine	NNS
cord-282246-wyanwvxa	218	25	have	have	VBP
cord-282246-wyanwvxa	218	26	been	be	VBN
cord-282246-wyanwvxa	218	27	developed	develop	VBN
cord-282246-wyanwvxa	218	28	or	or	CC
cord-282246-wyanwvxa	218	29	proposed	propose	VBN
cord-282246-wyanwvxa	218	30	.	.	.
cord-282246-wyanwvxa	219	1	The	the	DT
cord-282246-wyanwvxa	219	2	key	key	JJ
cord-282246-wyanwvxa	219	3	issue	issue	NN
cord-282246-wyanwvxa	219	4	to	to	TO
cord-282246-wyanwvxa	219	5	overcome	overcome	VB
cord-282246-wyanwvxa	219	6	in	in	IN
cord-282246-wyanwvxa	219	7	developing	develop	VBG
cord-282246-wyanwvxa	219	8	a	a	DT
cord-282246-wyanwvxa	219	9	live	live	JJ
cord-282246-wyanwvxa	219	10	viral	viral	JJ
cord-282246-wyanwvxa	219	11	vaccine	vaccine	NN
cord-282246-wyanwvxa	219	12	is	be	VBZ
cord-282246-wyanwvxa	219	13	to	to	TO
cord-282246-wyanwvxa	219	14	discover	discover	VB
cord-282246-wyanwvxa	219	15	a	a	DT
cord-282246-wyanwvxa	219	16	method	method	NN
cord-282246-wyanwvxa	219	17	that	that	WDT
cord-282246-wyanwvxa	219	18	reliably	reliably	RB
cord-282246-wyanwvxa	219	19	attenuates	attenuate	VBZ
cord-282246-wyanwvxa	219	20	viral	viral	JJ
cord-282246-wyanwvxa	219	21	pathogenicity	pathogenicity	NN
cord-282246-wyanwvxa	219	22	while	while	IN
cord-282246-wyanwvxa	219	23	retaining	retain	VBG
cord-282246-wyanwvxa	219	24	the	the	DT
cord-282246-wyanwvxa	219	25	ability	ability	NN
cord-282246-wyanwvxa	219	26	of	of	IN
cord-282246-wyanwvxa	219	27	the	the	DT
cord-282246-wyanwvxa	219	28	viral	viral	JJ
cord-282246-wyanwvxa	219	29	infection	infection	NN
cord-282246-wyanwvxa	219	30	to	to	TO
cord-282246-wyanwvxa	219	31	induce	induce	VB
cord-282246-wyanwvxa	219	32	protective	protective	JJ
cord-282246-wyanwvxa	219	33	immunity	immunity	NN
cord-282246-wyanwvxa	219	34	.	.	.
cord-282246-wyanwvxa	220	1	Traditionally	traditionally	RB
cord-282246-wyanwvxa	220	2	,	,	,
cord-282246-wyanwvxa	220	3	such	such	JJ
cord-282246-wyanwvxa	220	4	modification	modification	NN
cord-282246-wyanwvxa	220	5	has	have	VBZ
cord-282246-wyanwvxa	220	6	been	be	VBN
cord-282246-wyanwvxa	220	7	accomplished	accomplish	VBN
cord-282246-wyanwvxa	220	8	by	by	IN
cord-282246-wyanwvxa	220	9	multiple	multiple	JJ
cord-282246-wyanwvxa	220	10	passage	passage	NN
cord-282246-wyanwvxa	220	11	of	of	IN
cord-282246-wyanwvxa	220	12	virulent	virulent	JJ
cord-282246-wyanwvxa	220	13	viral	viral	JJ
cord-282246-wyanwvxa	220	14	strains	strain	NNS
cord-282246-wyanwvxa	220	15	in	in	IN
cord-282246-wyanwvxa	220	16	cell	cell	NN
cord-282246-wyanwvxa	220	17	culture	culture	NN
cord-282246-wyanwvxa	220	18	with	with	IN
cord-282246-wyanwvxa	220	19	the	the	DT
cord-282246-wyanwvxa	220	20	hope	hope	NN
cord-282246-wyanwvxa	220	21	that	that	IN
cord-282246-wyanwvxa	220	22	such	such	JJ
cord-282246-wyanwvxa	220	23	multiple	multiple	JJ
cord-282246-wyanwvxa	220	24	passages	passage	NNS
cord-282246-wyanwvxa	220	25	will	will	MD
cord-282246-wyanwvxa	220	26	lead	lead	VB
cord-282246-wyanwvxa	220	27	to	to	IN
cord-282246-wyanwvxa	220	28	the	the	DT
cord-282246-wyanwvxa	220	29	acquisition	acquisition	NN
cord-282246-wyanwvxa	220	30	of	of	IN
cord-282246-wyanwvxa	220	31	sufficient	sufficient	JJ
cord-282246-wyanwvxa	220	32	mutations	mutation	NNS
cord-282246-wyanwvxa	220	33	in	in	IN
cord-282246-wyanwvxa	220	34	the	the	DT
cord-282246-wyanwvxa	220	35	viral	viral	JJ
cord-282246-wyanwvxa	220	36	genome	genome	NN
cord-282246-wyanwvxa	220	37	(	(	-LRB-
cord-282246-wyanwvxa	220	38	acquired	acquire	VBN
cord-282246-wyanwvxa	220	39	to	to	TO
cord-282246-wyanwvxa	220	40	enhance	enhance	VB
cord-282246-wyanwvxa	220	41	cell	cell	NN
cord-282246-wyanwvxa	220	42	culture	culture	NN
cord-282246-wyanwvxa	220	43	replication	replication	NN
cord-282246-wyanwvxa	220	44	)	)	-RRB-
cord-282246-wyanwvxa	220	45	and	and	CC
cord-282246-wyanwvxa	220	46	that	that	IN
cord-282246-wyanwvxa	220	47	these	these	DT
cord-282246-wyanwvxa	220	48	cell	cell	NN
cord-282246-wyanwvxa	220	49	culture	culture	NN
cord-282246-wyanwvxa	220	50	adaptations	adaptation	NNS
cord-282246-wyanwvxa	220	51	will	will	MD
cord-282246-wyanwvxa	220	52	attenuate	attenuate	VB
cord-282246-wyanwvxa	220	53	viral	viral	JJ
cord-282246-wyanwvxa	220	54	pathogenicity	pathogenicity	NN
cord-282246-wyanwvxa	220	55	in	in	IN
cord-282246-wyanwvxa	220	56	the	the	DT
cord-282246-wyanwvxa	220	57	target	target	NN
cord-282246-wyanwvxa	220	58	host	host	NN
cord-282246-wyanwvxa	220	59	.	.	.
cord-282246-wyanwvxa	221	1	This	this	DT
cord-282246-wyanwvxa	221	2	strategy	strategy	NN
cord-282246-wyanwvxa	221	3	is	be	VBZ
cord-282246-wyanwvxa	221	4	VI	VI	NNP
cord-282246-wyanwvxa	221	5	.	.	.
cord-282246-wyanwvxa	222	1	MUCOSAL	MUCOSAL	NNP
cord-282246-wyanwvxa	222	2	VACCINES	vaccine	NNS
cord-282246-wyanwvxa	222	3	FOR	for	IN
cord-282246-wyanwvxa	222	4	VIRAL	viral	JJ
cord-282246-wyanwvxa	222	5	DISEASES	disease	NNS
cord-282246-wyanwvxa	222	6	time	time	NN
cord-282246-wyanwvxa	222	7	honored	honor	VBN
cord-282246-wyanwvxa	222	8	and	and	CC
cord-282246-wyanwvxa	222	9	has	have	VBZ
cord-282246-wyanwvxa	222	10	been	be	VBN
cord-282246-wyanwvxa	222	11	used	use	VBN
cord-282246-wyanwvxa	222	12	to	to	TO
cord-282246-wyanwvxa	222	13	develop	develop	VB
cord-282246-wyanwvxa	222	14	multiple	multiple	JJ
cord-282246-wyanwvxa	222	15	vaccines	vaccine	NNS
cord-282246-wyanwvxa	222	16	(	(	-LRB-
cord-282246-wyanwvxa	222	17	e.g.	e.g.	RB
cord-282246-wyanwvxa	222	18	,	,	,
cord-282246-wyanwvxa	222	19	live	live	JJ
cord-282246-wyanwvxa	222	20	polio	polio	NN
cord-282246-wyanwvxa	222	21	,	,	,
cord-282246-wyanwvxa	222	22	measles	measle	NNS
cord-282246-wyanwvxa	222	23	,	,	,
cord-282246-wyanwvxa	222	24	mumps	mumps	NN
cord-282246-wyanwvxa	222	25	,	,	,
cord-282246-wyanwvxa	222	26	rubella	rubella	NN
cord-282246-wyanwvxa	222	27	,	,	,
cord-282246-wyanwvxa	222	28	yellow	yellow	JJ
cord-282246-wyanwvxa	222	29	fever	fever	NN
cord-282246-wyanwvxa	222	30	,	,	,
cord-282246-wyanwvxa	222	31	and	and	CC
cord-282246-wyanwvxa	222	32	some	some	DT
cord-282246-wyanwvxa	222	33	RV	RV	NNP
cord-282246-wyanwvxa	222	34	vaccines	vaccine	NNS
cord-282246-wyanwvxa	222	35	)	)	-RRB-
cord-282246-wyanwvxa	222	36	.	.	.
cord-282246-wyanwvxa	223	1	While	while	IN
cord-282246-wyanwvxa	223	2	this	this	DT
cord-282246-wyanwvxa	223	3	approach	approach	NN
cord-282246-wyanwvxa	223	4	is	be	VBZ
cord-282246-wyanwvxa	223	5	frequently	frequently	RB
cord-282246-wyanwvxa	223	6	successful	successful	JJ
cord-282246-wyanwvxa	223	7	,	,	,
cord-282246-wyanwvxa	223	8	there	there	EX
cord-282246-wyanwvxa	223	9	is	be	VBZ
cord-282246-wyanwvxa	223	10	no	no	DT
cord-282246-wyanwvxa	223	11	way	way	NN
cord-282246-wyanwvxa	223	12	to	to	TO
cord-282246-wyanwvxa	223	13	determine	determine	VB
cord-282246-wyanwvxa	223	14	how	how	WRB
cord-282246-wyanwvxa	223	15	many	many	JJ
cord-282246-wyanwvxa	223	16	passages	passage	NNS
cord-282246-wyanwvxa	223	17	are	be	VBP
cord-282246-wyanwvxa	223	18	needed	need	VBN
cord-282246-wyanwvxa	223	19	to	to	TO
cord-282246-wyanwvxa	223	20	eliminate	eliminate	VB
cord-282246-wyanwvxa	223	21	residual	residual	JJ
cord-282246-wyanwvxa	223	22	virulence	virulence	NN
cord-282246-wyanwvxa	223	23	while	while	IN
cord-282246-wyanwvxa	223	24	retaining	retain	VBG
cord-282246-wyanwvxa	223	25	immunogenicity	immunogenicity	NN
cord-282246-wyanwvxa	223	26	,	,	,
cord-282246-wyanwvxa	223	27	so	so	CC
cord-282246-wyanwvxa	223	28	it	-PRON-	PRP
cord-282246-wyanwvxa	223	29	is	be	VBZ
cord-282246-wyanwvxa	223	30	often	often	RB
cord-282246-wyanwvxa	223	31	tedious	tedious	JJ
cord-282246-wyanwvxa	223	32	and	and	CC
cord-282246-wyanwvxa	223	33	always	always	RB
cord-282246-wyanwvxa	223	34	an	an	DT
cord-282246-wyanwvxa	223	35	inexact	inexact	JJ
cord-282246-wyanwvxa	223	36	approach	approach	NN
cord-282246-wyanwvxa	223	37	.	.	.
cord-282246-wyanwvxa	224	1	In	in	IN
cord-282246-wyanwvxa	224	2	addition	addition	NN
cord-282246-wyanwvxa	224	3	,	,	,
cord-282246-wyanwvxa	224	4	concerns	concern	NNS
cord-282246-wyanwvxa	224	5	about	about	IN
cord-282246-wyanwvxa	224	6	reversion	reversion	NN
cord-282246-wyanwvxa	224	7	to	to	IN
cord-282246-wyanwvxa	224	8	virulence	virulence	NN
cord-282246-wyanwvxa	224	9	are	be	VBP
cord-282246-wyanwvxa	224	10	always	always	RB
cord-282246-wyanwvxa	224	11	present	present	JJ
cord-282246-wyanwvxa	224	12	.	.	.
cord-282246-wyanwvxa	225	1	That	that	DT
cord-282246-wyanwvxa	225	2	said	say	VBD
cord-282246-wyanwvxa	225	3	,	,	,
cord-282246-wyanwvxa	225	4	this	this	DT
cord-282246-wyanwvxa	225	5	approach	approach	NN
cord-282246-wyanwvxa	225	6	was	be	VBD
cord-282246-wyanwvxa	225	7	used	use	VBN
cord-282246-wyanwvxa	225	8	successful	successful	JJ
cord-282246-wyanwvxa	225	9	to	to	TO
cord-282246-wyanwvxa	225	10	develop	develop	VB
cord-282246-wyanwvxa	225	11	a	a	DT
cord-282246-wyanwvxa	225	12	highly	highly	RB
cord-282246-wyanwvxa	225	13	effective	effective	JJ
cord-282246-wyanwvxa	225	14	human	human	JJ
cord-282246-wyanwvxa	225	15	RV	rv	NN
cord-282246-wyanwvxa	225	16	vaccine	vaccine	NN
cord-282246-wyanwvxa	225	17	(	(	-LRB-
cord-282246-wyanwvxa	225	18	R1	R1	NNP
cord-282246-wyanwvxa	225	19	,	,	,
cord-282246-wyanwvxa	225	20	Rotarix	Rotarix	NNP
cord-282246-wyanwvxa	225	21	)	)	-RRB-
cord-282246-wyanwvxa	225	22	,	,	,
cord-282246-wyanwvxa	225	23	which	which	WDT
cord-282246-wyanwvxa	225	24	consist	consist	VBP
cord-282246-wyanwvxa	225	25	of	of	IN
cord-282246-wyanwvxa	225	26	a	a	DT
cord-282246-wyanwvxa	225	27	single	single	JJ
cord-282246-wyanwvxa	225	28	human	human	JJ
cord-282246-wyanwvxa	225	29	RV	RV	NNP
cord-282246-wyanwvxa	225	30	strain	strain	NN
cord-282246-wyanwvxa	225	31	that	that	WDT
cord-282246-wyanwvxa	225	32	was	be	VBD
cord-282246-wyanwvxa	225	33	repeated	repeat	VBN
cord-282246-wyanwvxa	225	34	passed	pass	VBN
cord-282246-wyanwvxa	225	35	in	in	IN
cord-282246-wyanwvxa	225	36	several	several	JJ
cord-282246-wyanwvxa	225	37	cell	cell	NN
cord-282246-wyanwvxa	225	38	culture	culture	NN
cord-282246-wyanwvxa	225	39	systems	system	NNS
cord-282246-wyanwvxa	225	40	and	and	CC
cord-282246-wyanwvxa	225	41	,	,	,
cord-282246-wyanwvxa	225	42	over	over	IN
cord-282246-wyanwvxa	225	43	the	the	DT
cord-282246-wyanwvxa	225	44	passage	passage	NN
cord-282246-wyanwvxa	225	45	history	history	NN
cord-282246-wyanwvxa	225	46	,	,	,
cord-282246-wyanwvxa	225	47	became	become	VBD
cord-282246-wyanwvxa	225	48	attenuated	attenuated	JJ
cord-282246-wyanwvxa	225	49	in	in	IN
cord-282246-wyanwvxa	225	50	people	people	NNS
cord-282246-wyanwvxa	225	51	[	[	-LRB-
cord-282246-wyanwvxa	225	52	80	80	CD
cord-282246-wyanwvxa	225	53	]	]	-RRB-
cord-282246-wyanwvxa	225	54	.	.	.
cord-282246-wyanwvxa	226	1	While	while	IN
cord-282246-wyanwvxa	226	2	the	the	DT
cord-282246-wyanwvxa	226	3	genomic	genomic	JJ
cord-282246-wyanwvxa	226	4	sequence	sequence	NN
cord-282246-wyanwvxa	226	5	of	of	IN
cord-282246-wyanwvxa	226	6	both	both	CC
cord-282246-wyanwvxa	226	7	the	the	DT
cord-282246-wyanwvxa	226	8	virulent	virulent	JJ
cord-282246-wyanwvxa	226	9	wildtype	wildtype	NN
cord-282246-wyanwvxa	226	10	parental	parental	JJ
cord-282246-wyanwvxa	226	11	Rotarix	Rotarix	NNP
cord-282246-wyanwvxa	226	12	strain	strain	NN
cord-282246-wyanwvxa	226	13	and	and	CC
cord-282246-wyanwvxa	226	14	the	the	DT
cord-282246-wyanwvxa	226	15	eventual	eventual	JJ
cord-282246-wyanwvxa	226	16	vaccine	vaccine	NN
cord-282246-wyanwvxa	226	17	strain	strain	NN
cord-282246-wyanwvxa	226	18	are	be	VBP
cord-282246-wyanwvxa	226	19	known	know	VBN
cord-282246-wyanwvxa	226	20	,	,	,
cord-282246-wyanwvxa	226	21	the	the	DT
cord-282246-wyanwvxa	226	22	exact	exact	JJ
cord-282246-wyanwvxa	226	23	genomic	genomic	JJ
cord-282246-wyanwvxa	226	24	mutations	mutation	NNS
cord-282246-wyanwvxa	226	25	responsible	responsible	JJ
cord-282246-wyanwvxa	226	26	for	for	IN
cord-282246-wyanwvxa	226	27	attenuation	attenuation	NN
cord-282246-wyanwvxa	226	28	are	be	VBP
cord-282246-wyanwvxa	226	29	unclear	unclear	JJ
cord-282246-wyanwvxa	226	30	.	.	.
cord-282246-wyanwvxa	227	1	What	what	WP
cord-282246-wyanwvxa	227	2	has	have	VBZ
cord-282246-wyanwvxa	227	3	been	be	VBN
cord-282246-wyanwvxa	227	4	established	establish	VBN
cord-282246-wyanwvxa	227	5	,	,	,
cord-282246-wyanwvxa	227	6	however	however	RB
cord-282246-wyanwvxa	227	7	,	,	,
cord-282246-wyanwvxa	227	8	is	be	VBZ
cord-282246-wyanwvxa	227	9	that	that	IN
cord-282246-wyanwvxa	227	10	,	,	,
cord-282246-wyanwvxa	227	11	given	give	VBN
cord-282246-wyanwvxa	227	12	the	the	DT
cord-282246-wyanwvxa	227	13	very	very	RB
cord-282246-wyanwvxa	227	14	substantial	substantial	JJ
cord-282246-wyanwvxa	227	15	and	and	CC
cord-282246-wyanwvxa	227	16	decade	decade	NN
cord-282246-wyanwvxa	227	17	-	-	HYPH
cord-282246-wyanwvxa	227	18	long	long	JJ
cord-282246-wyanwvxa	227	19	safety	safety	NN
cord-282246-wyanwvxa	227	20	record	record	NN
cord-282246-wyanwvxa	227	21	,	,	,
cord-282246-wyanwvxa	227	22	this	this	DT
cord-282246-wyanwvxa	227	23	human	human	JJ
cord-282246-wyanwvxa	227	24	RV	RV	NNP
cord-282246-wyanwvxa	227	25	vaccine	vaccine	NN
cord-282246-wyanwvxa	227	26	strain	strain	NN
cord-282246-wyanwvxa	227	27	has	have	VBZ
cord-282246-wyanwvxa	227	28	sufficient	sufficient	JJ
cord-282246-wyanwvxa	227	29	attenuating	attenuate	VBG
cord-282246-wyanwvxa	227	30	mutations	mutation	NNS
cord-282246-wyanwvxa	227	31	to	to	TO
cord-282246-wyanwvxa	227	32	ensure	ensure	VB
cord-282246-wyanwvxa	227	33	a	a	DT
cord-282246-wyanwvxa	227	34	high	high	JJ
cord-282246-wyanwvxa	227	35	degree	degree	NN
cord-282246-wyanwvxa	227	36	of	of	IN
cord-282246-wyanwvxa	227	37	genetic	genetic	JJ
cord-282246-wyanwvxa	227	38	stability	stability	NN
cord-282246-wyanwvxa	227	39	in	in	IN
cord-282246-wyanwvxa	227	40	humans	human	NNS
cord-282246-wyanwvxa	227	41	.	.	.
cord-282246-wyanwvxa	228	1	Of	of	IN
cord-282246-wyanwvxa	228	2	note	note	NN
cord-282246-wyanwvxa	228	3	,	,	,
cord-282246-wyanwvxa	228	4	the	the	DT
cord-282246-wyanwvxa	228	5	R1	R1	NNP
cord-282246-wyanwvxa	228	6	Rotarix	Rotarix	NNP
cord-282246-wyanwvxa	228	7	vaccine	vaccine	NN
cord-282246-wyanwvxa	228	8	represents	represent	VBZ
cord-282246-wyanwvxa	228	9	a	a	DT
cord-282246-wyanwvxa	228	10	single	single	JJ
cord-282246-wyanwvxa	228	11	G	g	NN
cord-282246-wyanwvxa	228	12	and	and	CC
cord-282246-wyanwvxa	228	13	[	[	-LRB-
cord-282246-wyanwvxa	228	14	P	p	NN
cord-282246-wyanwvxa	228	15	]	]	-RRB-
cord-282246-wyanwvxa	228	16	serotype	serotype	NN
cord-282246-wyanwvxa	228	17	yet	yet	CC
cord-282246-wyanwvxa	228	18	reliably	reliably	RB
cord-282246-wyanwvxa	228	19	induces	induce	VBZ
cord-282246-wyanwvxa	228	20	protective	protective	JJ
cord-282246-wyanwvxa	228	21	immunity	immunity	NN
cord-282246-wyanwvxa	228	22	to	to	IN
cord-282246-wyanwvxa	228	23	virtually	virtually	RB
cord-282246-wyanwvxa	228	24	all	all	DT
cord-282246-wyanwvxa	228	25	frequently	frequently	RB
cord-282246-wyanwvxa	228	26	circulating	circulate	VBG
cord-282246-wyanwvxa	228	27	human	human	JJ
cord-282246-wyanwvxa	228	28	RV	rv	NN
cord-282246-wyanwvxa	228	29	strains	strain	NNS
cord-282246-wyanwvxa	228	30	.	.	.
cord-282246-wyanwvxa	229	1	This	this	DT
cord-282246-wyanwvxa	229	2	finding	finding	NN
cord-282246-wyanwvxa	229	3	strongly	strongly	RB
cord-282246-wyanwvxa	229	4	supports	support	VBZ
cord-282246-wyanwvxa	229	5	the	the	DT
cord-282246-wyanwvxa	229	6	conclusion	conclusion	NN
cord-282246-wyanwvxa	229	7	that	that	IN
cord-282246-wyanwvxa	229	8	serotype	serotype	NN
cord-282246-wyanwvxa	229	9	-	-	HYPH
cord-282246-wyanwvxa	229	10	specific	specific	JJ
cord-282246-wyanwvxa	229	11	immunity	immunity	NN
cord-282246-wyanwvxa	229	12	is	be	VBZ
cord-282246-wyanwvxa	229	13	not	not	RB
cord-282246-wyanwvxa	229	14	a	a	DT
cord-282246-wyanwvxa	229	15	major	major	JJ
cord-282246-wyanwvxa	229	16	determinant	determinant	NN
cord-282246-wyanwvxa	229	17	of	of	IN
cord-282246-wyanwvxa	229	18	immunity	immunity	NN
cord-282246-wyanwvxa	229	19	to	to	IN
cord-282246-wyanwvxa	229	20	severe	severe	JJ
cord-282246-wyanwvxa	229	21	RV	rv	NN
cord-282246-wyanwvxa	229	22	disease	disease	NN
cord-282246-wyanwvxa	229	23	in	in	IN
cord-282246-wyanwvxa	229	24	humans	human	NNS
cord-282246-wyanwvxa	229	25	[	[	-LRB-
cord-282246-wyanwvxa	229	26	81	81	CD
cord-282246-wyanwvxa	229	27	]	]	-RRB-
cord-282246-wyanwvxa	229	28	.	.	.
cord-282246-wyanwvxa	230	1	The	the	DT
cord-282246-wyanwvxa	230	2	other	other	JJ
cord-282246-wyanwvxa	230	3	strategy	strategy	NN
cord-282246-wyanwvxa	230	4	that	that	WDT
cord-282246-wyanwvxa	230	5	has	have	VBZ
cord-282246-wyanwvxa	230	6	proven	prove	VBN
cord-282246-wyanwvxa	230	7	highly	highly	RB
cord-282246-wyanwvxa	230	8	successful	successful	JJ
cord-282246-wyanwvxa	230	9	for	for	IN
cord-282246-wyanwvxa	230	10	the	the	DT
cord-282246-wyanwvxa	230	11	reproducible	reproducible	JJ
cord-282246-wyanwvxa	230	12	attenuation	attenuation	NN
cord-282246-wyanwvxa	230	13	of	of	IN
cord-282246-wyanwvxa	230	14	the	the	DT
cord-282246-wyanwvxa	230	15	RVs	rv	NNS
cord-282246-wyanwvxa	230	16	used	use	VBN
cord-282246-wyanwvxa	230	17	in	in	IN
cord-282246-wyanwvxa	230	18	live	live	JJ
cord-282246-wyanwvxa	230	19	attenuated	attenuated	JJ
cord-282246-wyanwvxa	230	20	RV	RV	NNP
cord-282246-wyanwvxa	230	21	vaccines	vaccine	NNS
cord-282246-wyanwvxa	230	22	has	have	VBZ
cord-282246-wyanwvxa	230	23	been	be	VBN
cord-282246-wyanwvxa	230	24	to	to	TO
cord-282246-wyanwvxa	230	25	take	take	VB
cord-282246-wyanwvxa	230	26	advantage	advantage	NN
cord-282246-wyanwvxa	230	27	of	of	IN
cord-282246-wyanwvxa	230	28	the	the	DT
cord-282246-wyanwvxa	230	29	HRR	HRR	NNP
cord-282246-wyanwvxa	230	30	(	(	-LRB-
cord-282246-wyanwvxa	230	31	see	see	VB
cord-282246-wyanwvxa	230	32	above	above	RB
cord-282246-wyanwvxa	230	33	)	)	-RRB-
cord-282246-wyanwvxa	230	34	of	of	IN
cord-282246-wyanwvxa	230	35	heterologous	heterologous	NNP
cord-282246-wyanwvxa	230	36	(	(	-LRB-
cord-282246-wyanwvxa	230	37	nonhuman	nonhuman	NN
cord-282246-wyanwvxa	230	38	origin	origin	NN
cord-282246-wyanwvxa	230	39	)	)	-RRB-
cord-282246-wyanwvxa	230	40	RVs	rv	NNS
cord-282246-wyanwvxa	230	41	as	as	IN
cord-282246-wyanwvxa	230	42	vaccine	vaccine	NN
cord-282246-wyanwvxa	230	43	candidates	candidate	NNS
cord-282246-wyanwvxa	230	44	for	for	IN
cord-282246-wyanwvxa	230	45	humans	human	NNS
cord-282246-wyanwvxa	230	46	[	[	-LRB-
cord-282246-wyanwvxa	230	47	82	82	CD
cord-282246-wyanwvxa	230	48	]	]	-RRB-
cord-282246-wyanwvxa	230	49	.	.	.
cord-282246-wyanwvxa	231	1	Several	several	JJ
cord-282246-wyanwvxa	231	2	currently	currently	RB
cord-282246-wyanwvxa	231	3	licensed	license	VBN
cord-282246-wyanwvxa	231	4	RV	RV	NNP
cord-282246-wyanwvxa	231	5	vaccines	vaccine	NNS
cord-282246-wyanwvxa	231	6	(	(	-LRB-
cord-282246-wyanwvxa	231	7	e.g.	e.g.	RB
cord-282246-wyanwvxa	231	8	,	,	,
cord-282246-wyanwvxa	231	9	the	the	DT
cord-282246-wyanwvxa	231	10	R5	R5	NNP
cord-282246-wyanwvxa	231	11	vaccines	vaccine	NNS
cord-282246-wyanwvxa	231	12	RotaTeq	RotaTeq	NNP
cord-282246-wyanwvxa	231	13	and	and	CC
cord-282246-wyanwvxa	231	14	Rotasil	Rotasil	NNP
cord-282246-wyanwvxa	231	15	and	and	CC
cord-282246-wyanwvxa	231	16	the	the	DT
cord-282246-wyanwvxa	231	17	R1	R1	NNP
cord-282246-wyanwvxa	231	18	vaccine	vaccine	NN
cord-282246-wyanwvxa	231	19	Rotavac	Rotavac	NNP
cord-282246-wyanwvxa	231	20	)	)	-RRB-
cord-282246-wyanwvxa	231	21	consist	consist	VBP
cord-282246-wyanwvxa	231	22	of	of	IN
cord-282246-wyanwvxa	231	23	either	either	DT
cord-282246-wyanwvxa	231	24	natural	natural	JJ
cord-282246-wyanwvxa	231	25	or	or	CC
cord-282246-wyanwvxa	231	26	experimentally	experimentally	RB
cord-282246-wyanwvxa	231	27	selected	select	VBN
cord-282246-wyanwvxa	231	28	reassortants	reassortant	NNS
cord-282246-wyanwvxa	231	29	between	between	IN
cord-282246-wyanwvxa	231	30	animal	animal	NN
cord-282246-wyanwvxa	231	31	RVs	rv	NNS
cord-282246-wyanwvxa	231	32	(	(	-LRB-
cord-282246-wyanwvxa	231	33	in	in	IN
cord-282246-wyanwvxa	231	34	these	these	DT
cord-282246-wyanwvxa	231	35	cases	case	NNS
cord-282246-wyanwvxa	231	36	,	,	,
cord-282246-wyanwvxa	231	37	all	all	DT
cord-282246-wyanwvxa	231	38	bovine	bovine	JJ
cord-282246-wyanwvxa	231	39	RVs	rv	NNS
cord-282246-wyanwvxa	231	40	)	)	-RRB-
cord-282246-wyanwvxa	231	41	and	and	CC
cord-282246-wyanwvxa	231	42	human	human	JJ
cord-282246-wyanwvxa	231	43	RVs	rv	NNS
cord-282246-wyanwvxa	231	44	.	.	.
cord-282246-wyanwvxa	232	1	Both	both	DT
cord-282246-wyanwvxa	232	2	R5	R5	NNP
cord-282246-wyanwvxa	232	3	vaccines	vaccine	NNS
cord-282246-wyanwvxa	232	4	are	be	VBP
cord-282246-wyanwvxa	232	5	pentavalent	pentavalent	JJ
cord-282246-wyanwvxa	232	6	constructs	construct	NNS
cord-282246-wyanwvxa	232	7	derived	derive	VBN
cord-282246-wyanwvxa	232	8	experimentally	experimentally	RB
cord-282246-wyanwvxa	232	9	on	on	IN
cord-282246-wyanwvxa	232	10	the	the	DT
cord-282246-wyanwvxa	232	11	basis	basis	NN
cord-282246-wyanwvxa	232	12	of	of	IN
cord-282246-wyanwvxa	232	13	bovine	bovine	JJ
cord-282246-wyanwvxa	232	14	RV	rv	NN
cord-282246-wyanwvxa	232	15	genomes	genome	NNS
cord-282246-wyanwvxa	232	16	but	but	CC
cord-282246-wyanwvxa	232	17	containing	contain	VBG
cord-282246-wyanwvxa	232	18	individual	individual	JJ
cord-282246-wyanwvxa	232	19	VP7-or	VP7-or	NNP
cord-282246-wyanwvxa	232	20	VP4s	vp4s	NN
cord-282246-wyanwvxa	232	21	-	-	HYPH
cord-282246-wyanwvxa	232	22	encoding	encode	VBG
cord-282246-wyanwvxa	232	23	genes	gene	NNS
cord-282246-wyanwvxa	232	24	derived	derive	VBN
cord-282246-wyanwvxa	232	25	from	from	IN
cord-282246-wyanwvxa	232	26	various	various	JJ
cord-282246-wyanwvxa	232	27	human	human	JJ
cord-282246-wyanwvxa	232	28	serotypes	serotype	NNS
cord-282246-wyanwvxa	232	29	.	.	.
cord-282246-wyanwvxa	233	1	RotaTeq	rotateq	NN
cord-282246-wyanwvxa	233	2	is	be	VBZ
cord-282246-wyanwvxa	233	3	broadly	broadly	RB
cord-282246-wyanwvxa	233	4	licensed	license	VBN
cord-282246-wyanwvxa	233	5	around	around	IN
cord-282246-wyanwvxa	233	6	the	the	DT
cord-282246-wyanwvxa	233	7	world	world	NN
cord-282246-wyanwvxa	233	8	,	,	,
cord-282246-wyanwvxa	233	9	while	while	IN
cord-282246-wyanwvxa	233	10	Rotasil	Rotasil	NNP
cord-282246-wyanwvxa	233	11	is	be	VBZ
cord-282246-wyanwvxa	233	12	currently	currently	RB
cord-282246-wyanwvxa	233	13	licensed	license	VBN
cord-282246-wyanwvxa	233	14	only	only	RB
cord-282246-wyanwvxa	233	15	in	in	IN
cord-282246-wyanwvxa	233	16	India	India	NNP
cord-282246-wyanwvxa	233	17	[	[	-LRB-
cord-282246-wyanwvxa	233	18	83	83	CD
cord-282246-wyanwvxa	233	19	]	]	-RRB-
cord-282246-wyanwvxa	233	20	.	.	.
cord-282246-wyanwvxa	234	1	Rotavac	Rotavac	NNP
cord-282246-wyanwvxa	234	2	is	be	VBZ
cord-282246-wyanwvxa	234	3	,	,	,
cord-282246-wyanwvxa	234	4	interestingly	interestingly	RB
cord-282246-wyanwvxa	234	5	,	,	,
cord-282246-wyanwvxa	234	6	a	a	DT
cord-282246-wyanwvxa	234	7	naturally	naturally	RB
cord-282246-wyanwvxa	234	8	occurring	occur	VBG
cord-282246-wyanwvxa	234	9	reassortant	reassortant	JJ
cord-282246-wyanwvxa	234	10	RV	RV	NNP
cord-282246-wyanwvxa	234	11	derived	derive	VBN
cord-282246-wyanwvxa	234	12	from	from	IN
cord-282246-wyanwvxa	234	13	a	a	DT
cord-282246-wyanwvxa	234	14	human	human	JJ
cord-282246-wyanwvxa	234	15	RV	rv	NN
cord-282246-wyanwvxa	234	16	and	and	CC
cord-282246-wyanwvxa	234	17	a	a	DT
cord-282246-wyanwvxa	234	18	bovine	bovine	JJ
cord-282246-wyanwvxa	234	19	RV	rv	NN
cord-282246-wyanwvxa	234	20	.	.	.
cord-282246-wyanwvxa	235	1	It	-PRON-	PRP
cord-282246-wyanwvxa	235	2	contains	contain	VBZ
cord-282246-wyanwvxa	235	3	only	only	RB
cord-282246-wyanwvxa	235	4	a	a	DT
cord-282246-wyanwvxa	235	5	bovine	bovine	JJ
cord-282246-wyanwvxa	235	6	VP4	VP4	NNP
cord-282246-wyanwvxa	235	7	,	,	,
cord-282246-wyanwvxa	235	8	with	with	IN
cord-282246-wyanwvxa	235	9	all	all	DT
cord-282246-wyanwvxa	235	10	other	other	JJ
cord-282246-wyanwvxa	235	11	ten	ten	CD
cord-282246-wyanwvxa	235	12	RV	RV	NNP
cord-282246-wyanwvxa	235	13	gene	gene	NN
cord-282246-wyanwvxa	235	14	segments	segment	NNS
cord-282246-wyanwvxa	235	15	derived	derive	VBN
cord-282246-wyanwvxa	235	16	from	from	IN
cord-282246-wyanwvxa	235	17	a	a	DT
cord-282246-wyanwvxa	235	18	human	human	JJ
cord-282246-wyanwvxa	235	19	RV	RV	NNP
cord-282246-wyanwvxa	235	20	strain	strain	NN
cord-282246-wyanwvxa	235	21	.	.	.
cord-282246-wyanwvxa	236	1	This	this	DT
cord-282246-wyanwvxa	236	2	virus	virus	NN
cord-282246-wyanwvxa	236	3	was	be	VBD
cord-282246-wyanwvxa	236	4	originally	originally	RB
cord-282246-wyanwvxa	236	5	isolated	isolate	VBN
cord-282246-wyanwvxa	236	6	from	from	IN
cord-282246-wyanwvxa	236	7	a	a	DT
cord-282246-wyanwvxa	236	8	neonatal	neonatal	JJ
cord-282246-wyanwvxa	236	9	nursery	nursery	NN
cord-282246-wyanwvxa	236	10	where	where	WRB
cord-282246-wyanwvxa	236	11	asymptomatic	asymptomatic	JJ
cord-282246-wyanwvxa	236	12	RV	RV	NNP
cord-282246-wyanwvxa	236	13	infection	infection	NN
cord-282246-wyanwvxa	236	14	was	be	VBD
cord-282246-wyanwvxa	236	15	endemic	endemic	JJ
cord-282246-wyanwvxa	236	16	[	[	-LRB-
cord-282246-wyanwvxa	236	17	84	84	CD
cord-282246-wyanwvxa	236	18	]	]	-RRB-
cord-282246-wyanwvxa	236	19	.	.	.
cord-282246-wyanwvxa	237	1	Finally	finally	RB
cord-282246-wyanwvxa	237	2	,	,	,
cord-282246-wyanwvxa	237	3	of	of	IN
cord-282246-wyanwvxa	237	4	relevance	relevance	NN
cord-282246-wyanwvxa	237	5	to	to	IN
cord-282246-wyanwvxa	237	6	this	this	DT
cord-282246-wyanwvxa	237	7	review	review	NN
cord-282246-wyanwvxa	237	8	,	,	,
cord-282246-wyanwvxa	237	9	an	an	DT
cord-282246-wyanwvxa	237	10	entirely	entirely	RB
cord-282246-wyanwvxa	237	11	lamb	lamb	NN
cord-282246-wyanwvxa	237	12	origin	origin	NN
cord-282246-wyanwvxa	237	13	RV	RV	NNP
cord-282246-wyanwvxa	237	14	strain	strain	NN
cord-282246-wyanwvxa	237	15	is	be	VBZ
cord-282246-wyanwvxa	237	16	currently	currently	RB
cord-282246-wyanwvxa	237	17	licensed	license	VBN
cord-282246-wyanwvxa	237	18	for	for	IN
cord-282246-wyanwvxa	237	19	RV	RV	NNP
cord-282246-wyanwvxa	237	20	prevention	prevention	NN
cord-282246-wyanwvxa	237	21	in	in	IN
cord-282246-wyanwvxa	237	22	China	China	NNP
cord-282246-wyanwvxa	237	23	.	.	.
cord-282246-wyanwvxa	238	1	This	this	DT
cord-282246-wyanwvxa	238	2	vaccine	vaccine	NN
cord-282246-wyanwvxa	238	3	is	be	VBZ
cord-282246-wyanwvxa	238	4	also	also	RB
cord-282246-wyanwvxa	238	5	highly	highly	RB
cord-282246-wyanwvxa	238	6	attenuated	attenuate	VBN
cord-282246-wyanwvxa	238	7	,	,	,
cord-282246-wyanwvxa	238	8	presumably	presumably	RB
cord-282246-wyanwvxa	238	9	because	because	IN
cord-282246-wyanwvxa	238	10	of	of	IN
cord-282246-wyanwvxa	238	11	the	the	DT
cord-282246-wyanwvxa	238	12	HRR	HRR	NNP
cord-282246-wyanwvxa	238	13	of	of	IN
cord-282246-wyanwvxa	238	14	a	a	DT
cord-282246-wyanwvxa	238	15	lamb	lamb	NN
cord-282246-wyanwvxa	238	16	origin	origin	NN
cord-282246-wyanwvxa	238	17	RV	RV	NNP
cord-282246-wyanwvxa	238	18	in	in	IN
cord-282246-wyanwvxa	238	19	humans	human	NNS
cord-282246-wyanwvxa	238	20	.	.	.
cord-282246-wyanwvxa	239	1	While	while	IN
cord-282246-wyanwvxa	239	2	this	this	DT
cord-282246-wyanwvxa	239	3	vaccine	vaccine	NN
cord-282246-wyanwvxa	239	4	seems	seem	VBZ
cord-282246-wyanwvxa	239	5	safe	safe	JJ
cord-282246-wyanwvxa	239	6	,	,	,
cord-282246-wyanwvxa	239	7	the	the	DT
cord-282246-wyanwvxa	239	8	data	datum	NNS
cord-282246-wyanwvxa	239	9	on	on	IN
cord-282246-wyanwvxa	239	10	its	-PRON-	PRP$
cord-282246-wyanwvxa	239	11	efficacy	efficacy	NN
cord-282246-wyanwvxa	239	12	are	be	VBP
cord-282246-wyanwvxa	239	13	limited	limit	VBN
cord-282246-wyanwvxa	239	14	[	[	-LRB-
cord-282246-wyanwvxa	239	15	85	85	CD
cord-282246-wyanwvxa	239	16	]	]	-RRB-
cord-282246-wyanwvxa	239	17	.	.	.
cord-282246-wyanwvxa	240	1	The	the	DT
cord-282246-wyanwvxa	240	2	key	key	JJ
cord-282246-wyanwvxa	240	3	point	point	NN
cord-282246-wyanwvxa	240	4	here	here	RB
cord-282246-wyanwvxa	240	5	is	be	VBZ
cord-282246-wyanwvxa	240	6	that	that	IN
cord-282246-wyanwvxa	240	7	all	all	PDT
cord-282246-wyanwvxa	240	8	these	these	DT
cord-282246-wyanwvxa	240	9	animal	animal	NN
cord-282246-wyanwvxa	240	10	virus	virus	NN
cord-282246-wyanwvxa	240	11	origin	origin	NN
cord-282246-wyanwvxa	240	12	based	base	VBN
cord-282246-wyanwvxa	240	13	RV	RV	NNP
cord-282246-wyanwvxa	240	14	vaccines	vaccine	NNS
cord-282246-wyanwvxa	240	15	are	be	VBP
cord-282246-wyanwvxa	240	16	highly	highly	RB
cord-282246-wyanwvxa	240	17	attenuated	attenuate	VBN
cord-282246-wyanwvxa	240	18	in	in	IN
cord-282246-wyanwvxa	240	19	humans	human	NNS
cord-282246-wyanwvxa	240	20	,	,	,
cord-282246-wyanwvxa	240	21	and	and	CC
cord-282246-wyanwvxa	240	22	this	this	DT
cord-282246-wyanwvxa	240	23	attenuation	attenuation	NN
cord-282246-wyanwvxa	240	24	,	,	,
cord-282246-wyanwvxa	240	25	as	as	IN
cord-282246-wyanwvxa	240	26	was	be	VBD
cord-282246-wyanwvxa	240	27	discussed	discuss	VBN
cord-282246-wyanwvxa	240	28	above	above	RB
cord-282246-wyanwvxa	240	29	,	,	,
cord-282246-wyanwvxa	240	30	is	be	VBZ
cord-282246-wyanwvxa	240	31	most	most	RBS
cord-282246-wyanwvxa	240	32	likely	likely	RB
cord-282246-wyanwvxa	240	33	based	base	VBN
cord-282246-wyanwvxa	240	34	on	on	IN
cord-282246-wyanwvxa	240	35	their	-PRON-	PRP$
cord-282246-wyanwvxa	240	36	host	host	NN
cord-282246-wyanwvxa	240	37	range	range	NN
cord-282246-wyanwvxa	240	38	replication	replication	NN
cord-282246-wyanwvxa	240	39	restriction	restriction	NN
cord-282246-wyanwvxa	240	40	in	in	IN
cord-282246-wyanwvxa	240	41	humans	human	NNS
cord-282246-wyanwvxa	240	42	.	.	.
cord-282246-wyanwvxa	241	1	This	this	DT
cord-282246-wyanwvxa	241	2	HRR	HRR	NNP
cord-282246-wyanwvxa	241	3	is	be	VBZ
cord-282246-wyanwvxa	241	4	primarily	primarily	RB
cord-282246-wyanwvxa	241	5	due	due	JJ
cord-282246-wyanwvxa	241	6	to	to	IN
cord-282246-wyanwvxa	241	7	the	the	DT
cord-282246-wyanwvxa	241	8	inability	inability	NN
cord-282246-wyanwvxa	241	9	of	of	IN
cord-282246-wyanwvxa	241	10	heterologous	heterologous	NNP
cord-282246-wyanwvxa	241	11	RV	RV	NNP
cord-282246-wyanwvxa	241	12	to	to	TO
cord-282246-wyanwvxa	241	13	efficiently	efficiently	RB
cord-282246-wyanwvxa	241	14	suppress	suppress	VB
cord-282246-wyanwvxa	241	15	the	the	DT
cord-282246-wyanwvxa	241	16	human	human	JJ
cord-282246-wyanwvxa	241	17	intestinal	intestinal	JJ
cord-282246-wyanwvxa	241	18	innate	innate	JJ
cord-282246-wyanwvxa	241	19	immune	immune	JJ
cord-282246-wyanwvxa	241	20	response	response	NN
cord-282246-wyanwvxa	241	21	,	,	,
cord-282246-wyanwvxa	241	22	primarily	primarily	RB
cord-282246-wyanwvxa	241	23	the	the	DT
cord-282246-wyanwvxa	241	24	human	human	JJ
cord-282246-wyanwvxa	241	25	IFN	IFN	NNP
cord-282246-wyanwvxa	241	26	response	response	NN
cord-282246-wyanwvxa	241	27	,	,	,
cord-282246-wyanwvxa	241	28	owing	owe	VBG
cord-282246-wyanwvxa	241	29	to	to	IN
cord-282246-wyanwvxa	241	30	the	the	DT
cord-282246-wyanwvxa	241	31	presence	presence	NN
cord-282246-wyanwvxa	241	32	of	of	IN
cord-282246-wyanwvxa	241	33	heterologous	heterologous	NNP
cord-282246-wyanwvxa	241	34	NSP1s	NSP1s	NNP
cord-282246-wyanwvxa	241	35	in	in	IN
cord-282246-wyanwvxa	241	36	the	the	DT
cord-282246-wyanwvxa	241	37	vaccine	vaccine	NN
cord-282246-wyanwvxa	241	38	candidates	candidate	NNS
cord-282246-wyanwvxa	241	39	.	.	.
cord-282246-wyanwvxa	242	1	The	the	DT
cord-282246-wyanwvxa	242	2	active	active	JJ
cord-282246-wyanwvxa	242	3	human	human	NN
cord-282246-wyanwvxa	242	4	IFN	IFN	NNP
cord-282246-wyanwvxa	242	5	response	response	NN
cord-282246-wyanwvxa	242	6	to	to	IN
cord-282246-wyanwvxa	242	7	these	these	DT
cord-282246-wyanwvxa	242	8	heterologous	heterologous	JJ
cord-282246-wyanwvxa	242	9	RV	RV	NNP
cord-282246-wyanwvxa	242	10	vaccines	vaccine	NNS
cord-282246-wyanwvxa	242	11	suppresses	suppress	VBZ
cord-282246-wyanwvxa	242	12	their	-PRON-	PRP$
cord-282246-wyanwvxa	242	13	replication	replication	NN
cord-282246-wyanwvxa	242	14	sufficiently	sufficiently	RB
cord-282246-wyanwvxa	242	15	to	to	TO
cord-282246-wyanwvxa	242	16	restrict	restrict	VB
cord-282246-wyanwvxa	242	17	pathogenicity	pathogenicity	NN
cord-282246-wyanwvxa	242	18	and	and	CC
cord-282246-wyanwvxa	242	19	reactogenicity	reactogenicity	NN
cord-282246-wyanwvxa	242	20	but	but	CC
cord-282246-wyanwvxa	242	21	not	not	RB
cord-282246-wyanwvxa	242	22	so	so	RB
cord-282246-wyanwvxa	242	23	much	much	JJ
cord-282246-wyanwvxa	242	24	that	that	IN
cord-282246-wyanwvxa	242	25	the	the	DT
cord-282246-wyanwvxa	242	26	generation	generation	NN
cord-282246-wyanwvxa	242	27	of	of	IN
cord-282246-wyanwvxa	242	28	effective	effective	JJ
cord-282246-wyanwvxa	242	29	RV	RV	NNP
cord-282246-wyanwvxa	242	30	immunity	immunity	NN
cord-282246-wyanwvxa	242	31	is	be	VBZ
cord-282246-wyanwvxa	242	32	suppressed	suppress	VBN
cord-282246-wyanwvxa	242	33	.	.	.
cord-282246-wyanwvxa	243	1	However	however	RB
cord-282246-wyanwvxa	243	2	,	,	,
cord-282246-wyanwvxa	243	3	in	in	IN
cord-282246-wyanwvxa	243	4	the	the	DT
cord-282246-wyanwvxa	243	5	case	case	NN
cord-282246-wyanwvxa	243	6	of	of	IN
cord-282246-wyanwvxa	243	7	the	the	DT
cord-282246-wyanwvxa	243	8	Indian	Indian	NNP
cord-282246-wyanwvxa	243	9	Rotavac	Rotavac	NNP
cord-282246-wyanwvxa	243	10	vaccine	vaccine	NN
cord-282246-wyanwvxa	243	11	,	,	,
cord-282246-wyanwvxa	243	12	attenuation	attenuation	NN
cord-282246-wyanwvxa	243	13	might	may	MD
cord-282246-wyanwvxa	243	14	be	be	VB
cord-282246-wyanwvxa	243	15	based	base	VBN
cord-282246-wyanwvxa	243	16	on	on	IN
cord-282246-wyanwvxa	243	17	the	the	DT
cord-282246-wyanwvxa	243	18	heterologous	heterologous	JJ
cord-282246-wyanwvxa	243	19	bovine	bovine	JJ
cord-282246-wyanwvxa	243	20	origin	origin	NN
cord-282246-wyanwvxa	243	21	VP4	VP4	NNP
cord-282246-wyanwvxa	243	22	,	,	,
cord-282246-wyanwvxa	243	23	which	which	WDT
cord-282246-wyanwvxa	243	24	might	may	MD
cord-282246-wyanwvxa	243	25	be	be	VB
cord-282246-wyanwvxa	243	26	expected	expect	VBN
cord-282246-wyanwvxa	243	27	to	to	TO
cord-282246-wyanwvxa	243	28	reduce	reduce	VB
cord-282246-wyanwvxa	243	29	RV	rv	NN
cord-282246-wyanwvxa	243	30	binding	bind	VBG
cord-282246-wyanwvxa	243	31	to	to	IN
cord-282246-wyanwvxa	243	32	human	human	JJ
cord-282246-wyanwvxa	243	33	IECs	iec	NNS
cord-282246-wyanwvxa	243	34	.	.	.
cord-282246-wyanwvxa	244	1	The	the	DT
cord-282246-wyanwvxa	244	2	big	big	JJ
cord-282246-wyanwvxa	244	3	question	question	NN
cord-282246-wyanwvxa	244	4	for	for	IN
cord-282246-wyanwvxa	244	5	the	the	DT
cord-282246-wyanwvxa	244	6	future	future	NN
cord-282246-wyanwvxa	244	7	is	be	VBZ
cord-282246-wyanwvxa	244	8	whether	whether	IN
cord-282246-wyanwvxa	244	9	,	,	,
cord-282246-wyanwvxa	244	10	with	with	IN
cord-282246-wyanwvxa	244	11	the	the	DT
cord-282246-wyanwvxa	244	12	advent	advent	NN
cord-282246-wyanwvxa	244	13	of	of	IN
cord-282246-wyanwvxa	244	14	a	a	DT
cord-282246-wyanwvxa	244	15	tractable	tractable	JJ
cord-282246-wyanwvxa	244	16	reverse	reverse	JJ
cord-282246-wyanwvxa	244	17	genetic	genetic	JJ
cord-282246-wyanwvxa	244	18	system	system	NN
cord-282246-wyanwvxa	244	19	and	and	CC
cord-282246-wyanwvxa	244	20	our	-PRON-	PRP$
cord-282246-wyanwvxa	244	21	improved	improved	JJ
cord-282246-wyanwvxa	244	22	understanding	understanding	NN
cord-282246-wyanwvxa	244	23	of	of	IN
cord-282246-wyanwvxa	244	24	the	the	DT
cord-282246-wyanwvxa	244	25	genetic	genetic	JJ
cord-282246-wyanwvxa	244	26	determinants	determinant	NNS
cord-282246-wyanwvxa	244	27	of	of	IN
cord-282246-wyanwvxa	244	28	HRR	HRR	NNP
cord-282246-wyanwvxa	244	29	,	,	,
cord-282246-wyanwvxa	244	30	we	-PRON-	PRP
cord-282246-wyanwvxa	244	31	will	will	MD
cord-282246-wyanwvxa	244	32	be	be	VB
cord-282246-wyanwvxa	244	33	able	able	JJ
cord-282246-wyanwvxa	244	34	to	to	TO
cord-282246-wyanwvxa	244	35	better	well	RBR
cord-282246-wyanwvxa	244	36	fine	fine	JJ
cord-282246-wyanwvxa	244	37	-	-	HYPH
cord-282246-wyanwvxa	244	38	tune	tune	VB
cord-282246-wyanwvxa	244	39	the	the	DT
cord-282246-wyanwvxa	244	40	replication	replication	NN
cord-282246-wyanwvxa	244	41	competence	competence	NN
cord-282246-wyanwvxa	244	42	and	and	CC
cord-282246-wyanwvxa	244	43	immunogenicity	immunogenicity	NN
cord-282246-wyanwvxa	244	44	potential	potential	NN
cord-282246-wyanwvxa	244	45	of	of	IN
cord-282246-wyanwvxa	244	46	RV	RV	NNP
cord-282246-wyanwvxa	244	47	vaccine	vaccine	NN
cord-282246-wyanwvxa	244	48	candidates	candidate	NNS
cord-282246-wyanwvxa	244	49	to	to	TO
cord-282246-wyanwvxa	244	50	further	further	RB
cord-282246-wyanwvxa	244	51	enhance	enhance	VB
cord-282246-wyanwvxa	244	52	their	-PRON-	PRP$
cord-282246-wyanwvxa	244	53	efficacy	efficacy	NN
cord-282246-wyanwvxa	244	54	.	.	.
cord-282246-wyanwvxa	245	1	Pathogen	pathogen	NN
cord-282246-wyanwvxa	245	2	-	-	HYPH
cord-282246-wyanwvxa	245	3	specific	specific	JJ
cord-282246-wyanwvxa	245	4	burdens	burden	NNS
cord-282246-wyanwvxa	245	5	of	of	IN
cord-282246-wyanwvxa	245	6	community	community	NN
cord-282246-wyanwvxa	245	7	diarrhoea	diarrhoea	NN
cord-282246-wyanwvxa	245	8	in	in	IN
cord-282246-wyanwvxa	245	9	developing	develop	VBG
cord-282246-wyanwvxa	245	10	countries	country	NNS
cord-282246-wyanwvxa	245	11	:	:	:
cord-282246-wyanwvxa	245	12	a	a	DT
cord-282246-wyanwvxa	245	13	multisite	multisite	JJ
cord-282246-wyanwvxa	245	14	birth	birth	NN
cord-282246-wyanwvxa	245	15	cohort	cohort	NN
cord-282246-wyanwvxa	245	16	study	study	NN
cord-282246-wyanwvxa	245	17	(	(	-LRB-
cord-282246-wyanwvxa	245	18	MAL	MAL	NNP
cord-282246-wyanwvxa	245	19	-	-	HYPH
cord-282246-wyanwvxa	245	20	ED	ED	NNP
cord-282246-wyanwvxa	245	21	)	)	-RRB-
cord-282246-wyanwvxa	245	22	Global	Global	NNP
cord-282246-wyanwvxa	245	23	,	,	,
cord-282246-wyanwvxa	245	24	regional	regional	JJ
cord-282246-wyanwvxa	245	25	,	,	,
cord-282246-wyanwvxa	245	26	and	and	CC
cord-282246-wyanwvxa	245	27	national	national	JJ
cord-282246-wyanwvxa	245	28	estimates	estimate	NNS
cord-282246-wyanwvxa	245	29	of	of	IN
cord-282246-wyanwvxa	245	30	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	245	31	mortality	mortality	NN
cord-282246-wyanwvxa	245	32	in	in	IN
cord-282246-wyanwvxa	245	33	children	child	NNS
cord-282246-wyanwvxa	245	34	,	,	,
cord-282246-wyanwvxa	245	35	5	5	CD
cord-282246-wyanwvxa	245	36	years	year	NNS
cord-282246-wyanwvxa	245	37	of	of	IN
cord-282246-wyanwvxa	245	38	age	age	NN
cord-282246-wyanwvxa	245	39	Fields	field	NNS
cord-282246-wyanwvxa	245	40	virology	virology	NN
cord-282246-wyanwvxa	246	1	The	the	DT
cord-282246-wyanwvxa	246	2	battle	battle	NN
cord-282246-wyanwvxa	246	3	between	between	IN
cord-282246-wyanwvxa	246	4	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	246	5	and	and	CC
cord-282246-wyanwvxa	246	6	its	-PRON-	PRP$
cord-282246-wyanwvxa	246	7	host	host	NN
cord-282246-wyanwvxa	246	8	for	for	IN
cord-282246-wyanwvxa	246	9	control	control	NN
cord-282246-wyanwvxa	246	10	of	of	IN
cord-282246-wyanwvxa	246	11	the	the	DT
cord-282246-wyanwvxa	246	12	interferon	interferon	NN
cord-282246-wyanwvxa	246	13	signaling	signal	VBG
cord-282246-wyanwvxa	246	14	pathway	pathway	NN
cord-282246-wyanwvxa	246	15	Activation	Activation	NNP
cord-282246-wyanwvxa	246	16	of	of	IN
cord-282246-wyanwvxa	246	17	host	host	NN
cord-282246-wyanwvxa	246	18	pattern	pattern	NN
cord-282246-wyanwvxa	246	19	recognition	recognition	NN
cord-282246-wyanwvxa	246	20	receptors	receptor	NNS
cord-282246-wyanwvxa	246	21	by	by	IN
cord-282246-wyanwvxa	246	22	viruses	virus	NNS
cord-282246-wyanwvxa	246	23	or	or	CC
cord-282246-wyanwvxa	246	24	not	not	RB
cord-282246-wyanwvxa	246	25	totranslate	totranslate	NNP
cord-282246-wyanwvxa	246	26	:	:	:
cord-282246-wyanwvxa	246	27	viral	viral	JJ
cord-282246-wyanwvxa	246	28	and	and	CC
cord-282246-wyanwvxa	246	29	host	host	NN
cord-282246-wyanwvxa	246	30	mRNA	mrna	NN
cord-282246-wyanwvxa	246	31	regulation	regulation	NN
cord-282246-wyanwvxa	246	32	by	by	IN
cord-282246-wyanwvxa	246	33	interferon	interferon	NN
cord-282246-wyanwvxa	246	34	-	-	HYPH
cord-282246-wyanwvxa	246	35	stimulated	stimulate	VBN
cord-282246-wyanwvxa	246	36	genes	gene	NNS
cord-282246-wyanwvxa	246	37	Distinct	distinct	JJ
cord-282246-wyanwvxa	246	38	roles	role	NNS
cord-282246-wyanwvxa	246	39	of	of	IN
cord-282246-wyanwvxa	246	40	type	type	NN
cord-282246-wyanwvxa	246	41	I	-PRON-	PRP
cord-282246-wyanwvxa	246	42	and	and	CC
cord-282246-wyanwvxa	246	43	type	type	NN
cord-282246-wyanwvxa	246	44	III	iii	CD
cord-282246-wyanwvxa	246	45	interferons	interferon	NNS
cord-282246-wyanwvxa	246	46	in	in	IN
cord-282246-wyanwvxa	246	47	intestinal	intestinal	JJ
cord-282246-wyanwvxa	246	48	immunity	immunity	NN
cord-282246-wyanwvxa	246	49	to	to	IN
cord-282246-wyanwvxa	246	50	homologous	homologous	JJ
cord-282246-wyanwvxa	246	51	and	and	CC
cord-282246-wyanwvxa	246	52	heterologous	heterologous	JJ
cord-282246-wyanwvxa	246	53	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	246	54	infections	infection	NNS
cord-282246-wyanwvxa	247	1	The	the	DT
cord-282246-wyanwvxa	247	2	early	early	JJ
cord-282246-wyanwvxa	247	3	interferon	interferon	NN
cord-282246-wyanwvxa	247	4	response	response	NN
cord-282246-wyanwvxa	247	5	to	to	IN
cord-282246-wyanwvxa	247	6	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	247	7	is	be	VBZ
cord-282246-wyanwvxa	247	8	regulated	regulate	VBN
cord-282246-wyanwvxa	247	9	by	by	IN
cord-282246-wyanwvxa	247	10	PKR	PKR	NNP
cord-282246-wyanwvxa	247	11	and	and	CC
cord-282246-wyanwvxa	247	12	depends	depend	VBZ
cord-282246-wyanwvxa	247	13	on	on	IN
cord-282246-wyanwvxa	247	14	MAVS	MAVS	NNP
cord-282246-wyanwvxa	247	15	/	/	,
cord-282246-wyanwvxa	247	16	IPS-1	IPS-1	NNP
cord-282246-wyanwvxa	247	17	,	,	,
cord-282246-wyanwvxa	247	18	RIG	rig	NN
cord-282246-wyanwvxa	247	19	-	-	:
cord-282246-wyanwvxa	247	20	I	I	NNP
cord-282246-wyanwvxa	247	21	,	,	,
cord-282246-wyanwvxa	247	22	MDA-5	MDA-5	NNP
cord-282246-wyanwvxa	247	23	,	,	,
cord-282246-wyanwvxa	247	24	and	and	CC
cord-282246-wyanwvxa	248	1	IRF3	IRF3	NNP
cord-282246-wyanwvxa	248	2	RIG	rig	NN
cord-282246-wyanwvxa	248	3	-	-	:
cord-282246-wyanwvxa	248	4	I	I	NNP
cord-282246-wyanwvxa	248	5	/	/	SYM
cord-282246-wyanwvxa	248	6	MDA5	MDA5	NNP
cord-282246-wyanwvxa	248	7	/	/	SYM
cord-282246-wyanwvxa	248	8	MAVS	MAVS	NNPS
cord-282246-wyanwvxa	248	9	are	be	VBP
cord-282246-wyanwvxa	248	10	required	require	VBN
cord-282246-wyanwvxa	248	11	to	to	TO
cord-282246-wyanwvxa	248	12	signal	signal	VB
cord-282246-wyanwvxa	248	13	a	a	DT
cord-282246-wyanwvxa	248	14	protective	protective	JJ
cord-282246-wyanwvxa	248	15	IFN	IFN	NNP
cord-282246-wyanwvxa	248	16	response	response	NN
cord-282246-wyanwvxa	248	17	in	in	IN
cord-282246-wyanwvxa	248	18	rotavirusinfected	rotavirusinfecte	VBN
cord-282246-wyanwvxa	248	19	intestinal	intestinal	JJ
cord-282246-wyanwvxa	248	20	epithelium	epithelium	NN
cord-282246-wyanwvxa	248	21	Characterization	characterization	NN
cord-282246-wyanwvxa	248	22	of	of	IN
cord-282246-wyanwvxa	248	23	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	248	24	RNAs	rna	NNS
cord-282246-wyanwvxa	248	25	that	that	WDT
cord-282246-wyanwvxa	248	26	activate	activate	VBP
cord-282246-wyanwvxa	248	27	innate	innate	JJ
cord-282246-wyanwvxa	248	28	immune	immune	JJ
cord-282246-wyanwvxa	248	29	signaling	signal	VBG
cord-282246-wyanwvxa	248	30	through	through	IN
cord-282246-wyanwvxa	248	31	the	the	DT
cord-282246-wyanwvxa	248	32	RIG	rig	NN
cord-282246-wyanwvxa	248	33	-	-	HYPH
cord-282246-wyanwvxa	248	34	I	i	NN
cord-282246-wyanwvxa	248	35	-	-	HYPH
cord-282246-wyanwvxa	248	36	like	like	JJ
cord-282246-wyanwvxa	248	37	receptors	receptor	NNS
cord-282246-wyanwvxa	249	1	The	the	DT
cord-282246-wyanwvxa	249	2	innate	innate	JJ
cord-282246-wyanwvxa	249	3	immune	immune	JJ
cord-282246-wyanwvxa	249	4	receptor	receptor	NN
cord-282246-wyanwvxa	249	5	MDA5	MDA5	NNP
cord-282246-wyanwvxa	249	6	limits	limit	VBZ
cord-282246-wyanwvxa	249	7	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	249	8	infection	infection	NN
cord-282246-wyanwvxa	249	9	but	but	CC
cord-282246-wyanwvxa	249	10	promotes	promote	VBZ
cord-282246-wyanwvxa	249	11	cell	cell	NN
cord-282246-wyanwvxa	249	12	death	death	NN
cord-282246-wyanwvxa	249	13	and	and	CC
cord-282246-wyanwvxa	249	14	pancreatic	pancreatic	JJ
cord-282246-wyanwvxa	249	15	inflammation	inflammation	NN
cord-282246-wyanwvxa	250	1	MyD88-mediated	MyD88-mediated	NNP
cord-282246-wyanwvxa	250	2	TLR	TLR	NNP
cord-282246-wyanwvxa	250	3	signaling	signal	VBG
cord-282246-wyanwvxa	250	4	protects	protect	VBZ
cord-282246-wyanwvxa	250	5	against	against	IN
cord-282246-wyanwvxa	250	6	acute	acute	JJ
cord-282246-wyanwvxa	250	7	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	250	8	infection	infection	NN
cord-282246-wyanwvxa	250	9	while	while	IN
cord-282246-wyanwvxa	250	10	inflammasome	inflammasome	NN
cord-282246-wyanwvxa	250	11	cytokines	cytokine	NNS
cord-282246-wyanwvxa	250	12	direct	direct	JJ
cord-282246-wyanwvxa	250	13	Ab	Ab	NNP
cord-282246-wyanwvxa	250	14	response	response	NN
cord-282246-wyanwvxa	250	15	Rotavirus	rotavirus	NN
cord-282246-wyanwvxa	250	16	activates	activate	VBZ
cord-282246-wyanwvxa	250	17	lymphocytes	lymphocyte	NNS
cord-282246-wyanwvxa	250	18	from	from	IN
cord-282246-wyanwvxa	250	19	non	non	JJ
cord-282246-wyanwvxa	250	20	-	-	JJ
cord-282246-wyanwvxa	250	21	obese	obese	JJ
cord-282246-wyanwvxa	250	22	diabetic	diabetic	JJ
cord-282246-wyanwvxa	250	23	mice	mouse	NNS
cord-282246-wyanwvxa	250	24	by	by	IN
cord-282246-wyanwvxa	250	25	triggering	trigger	VBG
cord-282246-wyanwvxa	250	26	toll	toll	NN
cord-282246-wyanwvxa	250	27	-	-	HYPH
cord-282246-wyanwvxa	250	28	like	like	JJ
cord-282246-wyanwvxa	250	29	receptor	receptor	NN
cord-282246-wyanwvxa	250	30	7	7	CD
cord-282246-wyanwvxa	250	31	signaling	signaling	NN
cord-282246-wyanwvxa	250	32	and	and	CC
cord-282246-wyanwvxa	250	33	interferon	interferon	NN
cord-282246-wyanwvxa	250	34	production	production	NN
cord-282246-wyanwvxa	250	35	in	in	IN
cord-282246-wyanwvxa	250	36	plasmacytoid	plasmacytoid	NNP
cord-282246-wyanwvxa	250	37	dendritic	dendritic	JJ
cord-282246-wyanwvxa	250	38	cells	cell	NNS
cord-282246-wyanwvxa	250	39	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	250	40	NSP4	NSP4	NNP
cord-282246-wyanwvxa	250	41	triggers	trigger	VBZ
cord-282246-wyanwvxa	250	42	secretion	secretion	NN
cord-282246-wyanwvxa	250	43	of	of	IN
cord-282246-wyanwvxa	250	44	proinflammatory	proinflammatory	JJ
cord-282246-wyanwvxa	250	45	cytokines	cytokine	NNS
cord-282246-wyanwvxa	250	46	from	from	IN
cord-282246-wyanwvxa	250	47	macrophages	macrophage	NNS
cord-282246-wyanwvxa	250	48	via	via	IN
cord-282246-wyanwvxa	250	49	toll	toll	NN
cord-282246-wyanwvxa	250	50	-	-	HYPH
cord-282246-wyanwvxa	250	51	like	like	JJ
cord-282246-wyanwvxa	250	52	receptor	receptor	NN
cord-282246-wyanwvxa	250	53	2	2	CD
cord-282246-wyanwvxa	250	54	Porcine	porcine	JJ
cord-282246-wyanwvxa	250	55	small	small	JJ
cord-282246-wyanwvxa	250	56	intestinal	intestinal	JJ
cord-282246-wyanwvxa	250	57	epithelial	epithelial	JJ
cord-282246-wyanwvxa	250	58	cell	cell	NN
cord-282246-wyanwvxa	250	59	line	line	NN
cord-282246-wyanwvxa	250	60	(	(	-LRB-
cord-282246-wyanwvxa	250	61	IPEC	IPEC	NNP
cord-282246-wyanwvxa	250	62	-	-	HYPH
cord-282246-wyanwvxa	250	63	J2	J2	NNP
cord-282246-wyanwvxa	250	64	)	)	-RRB-
cord-282246-wyanwvxa	250	65	of	of	IN
cord-282246-wyanwvxa	250	66	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	250	67	infection	infection	NN
cord-282246-wyanwvxa	250	68	as	as	IN
cord-282246-wyanwvxa	250	69	a	a	DT
cord-282246-wyanwvxa	250	70	new	new	JJ
cord-282246-wyanwvxa	250	71	model	model	NN
cord-282246-wyanwvxa	250	72	for	for	IN
cord-282246-wyanwvxa	250	73	the	the	DT
cord-282246-wyanwvxa	250	74	study	study	NN
cord-282246-wyanwvxa	250	75	of	of	IN
cord-282246-wyanwvxa	250	76	innate	innate	JJ
cord-282246-wyanwvxa	250	77	immune	immune	JJ
cord-282246-wyanwvxa	250	78	responses	response	NNS
cord-282246-wyanwvxa	250	79	to	to	IN
cord-282246-wyanwvxa	250	80	rotaviruses	rotaviruses	NNP
cord-282246-wyanwvxa	250	81	and	and	CC
cord-282246-wyanwvxa	250	82	probiotics	probiotics	NNPS
cord-282246-wyanwvxa	250	83	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	250	84	structural	structural	JJ
cord-282246-wyanwvxa	250	85	proteins	protein	NNS
cord-282246-wyanwvxa	250	86	and	and	CC
cord-282246-wyanwvxa	250	87	dsRNA	dsRNA	NNS
cord-282246-wyanwvxa	250	88	are	be	VBP
cord-282246-wyanwvxa	250	89	required	require	VBN
cord-282246-wyanwvxa	250	90	for	for	IN
cord-282246-wyanwvxa	250	91	the	the	DT
cord-282246-wyanwvxa	250	92	human	human	JJ
cord-282246-wyanwvxa	250	93	primary	primary	JJ
cord-282246-wyanwvxa	250	94	plasmacytoid	plasmacytoid	NNP
cord-282246-wyanwvxa	250	95	dendritic	dendritic	JJ
cord-282246-wyanwvxa	250	96	cell	cell	NN
cord-282246-wyanwvxa	250	97	IFNalpha	ifnalpha	NN
cord-282246-wyanwvxa	250	98	response	response	NN
cord-282246-wyanwvxa	250	99	Viral	viral	JJ
cord-282246-wyanwvxa	250	100	infection	infection	NN
cord-282246-wyanwvxa	250	101	.	.	.
cord-282246-wyanwvxa	251	1	Prevention	prevention	NN
cord-282246-wyanwvxa	251	2	and	and	CC
cord-282246-wyanwvxa	251	3	cure	cure	NN
cord-282246-wyanwvxa	251	4	of	of	IN
cord-282246-wyanwvxa	251	5	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	251	6	infection	infection	NN
cord-282246-wyanwvxa	251	7	via	via	IN
cord-282246-wyanwvxa	252	1	TLR5	TLR5	NNP
cord-282246-wyanwvxa	252	2	/	/	SYM
cord-282246-wyanwvxa	252	3	NLRC4-mediated	nlrc4-mediated	JJ
cord-282246-wyanwvxa	252	4	production	production	NN
cord-282246-wyanwvxa	252	5	of	of	IN
cord-282246-wyanwvxa	252	6	IL-22	IL-22	NNP
cord-282246-wyanwvxa	252	7	and	and	CC
cord-282246-wyanwvxa	252	8	IL-18	IL-18	NNP
cord-282246-wyanwvxa	252	9	Age	Age	NNP
cord-282246-wyanwvxa	252	10	-	-	HYPH
cord-282246-wyanwvxa	252	11	dependent	dependent	JJ
cord-282246-wyanwvxa	252	12	TLR3	tlr3	CD
cord-282246-wyanwvxa	252	13	expression	expression	NN
cord-282246-wyanwvxa	252	14	of	of	IN
cord-282246-wyanwvxa	252	15	the	the	DT
cord-282246-wyanwvxa	252	16	intestinal	intestinal	JJ
cord-282246-wyanwvxa	252	17	epithelium	epithelium	NN
cord-282246-wyanwvxa	252	18	contributes	contribute	VBZ
cord-282246-wyanwvxa	252	19	to	to	IN
cord-282246-wyanwvxa	252	20	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	252	21	susceptibility	susceptibility	NN
cord-282246-wyanwvxa	252	22	A	a	DT
cord-282246-wyanwvxa	252	23	paradox	paradox	NN
cord-282246-wyanwvxa	252	24	of	of	IN
cord-282246-wyanwvxa	252	25	transcriptional	transcriptional	JJ
cord-282246-wyanwvxa	252	26	and	and	CC
cord-282246-wyanwvxa	252	27	functional	functional	JJ
cord-282246-wyanwvxa	252	28	innate	innate	JJ
cord-282246-wyanwvxa	252	29	interferon	interferon	NN
cord-282246-wyanwvxa	252	30	responses	response	NNS
cord-282246-wyanwvxa	252	31	of	of	IN
cord-282246-wyanwvxa	252	32	human	human	JJ
cord-282246-wyanwvxa	252	33	intestinal	intestinal	JJ
cord-282246-wyanwvxa	252	34	enteroids	enteroid	NNS
cord-282246-wyanwvxa	252	35	to	to	IN
cord-282246-wyanwvxa	252	36	enteric	enteric	JJ
cord-282246-wyanwvxa	252	37	virus	virus	NN
cord-282246-wyanwvxa	252	38	infection	infection	NN
cord-282246-wyanwvxa	252	39	Frequencies	Frequencies	NNPS
cord-282246-wyanwvxa	252	40	of	of	IN
cord-282246-wyanwvxa	252	41	virus	virus	NN
cord-282246-wyanwvxa	252	42	-	-	HYPH
cord-282246-wyanwvxa	252	43	specific	specific	JJ
cord-282246-wyanwvxa	252	44	CD4(1	cd4(1	NN
cord-282246-wyanwvxa	252	45	)	)	-RRB-
cord-282246-wyanwvxa	252	46	and	and	CC
cord-282246-wyanwvxa	253	1	CD8(1	CD8(1	NNP
cord-282246-wyanwvxa	253	2	)	)	-RRB-
cord-282246-wyanwvxa	253	3	T	t	NN
cord-282246-wyanwvxa	253	4	lymphocytes	lymphocyte	NNS
cord-282246-wyanwvxa	253	5	secreting	secrete	VBG
cord-282246-wyanwvxa	253	6	gamma	gamma	NN
cord-282246-wyanwvxa	253	7	interferon	interferon	NN
cord-282246-wyanwvxa	253	8	after	after	IN
cord-282246-wyanwvxa	253	9	acute	acute	JJ
cord-282246-wyanwvxa	253	10	natural	natural	JJ
cord-282246-wyanwvxa	253	11	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	253	12	infection	infection	NN
cord-282246-wyanwvxa	253	13	in	in	IN
cord-282246-wyanwvxa	253	14	children	child	NNS
cord-282246-wyanwvxa	253	15	and	and	CC
cord-282246-wyanwvxa	253	16	adults	adult	NNS
cord-282246-wyanwvxa	254	1	The	the	DT
cord-282246-wyanwvxa	254	2	cloning	cloning	NN
cord-282246-wyanwvxa	254	3	of	of	IN
cord-282246-wyanwvxa	254	4	cattle	cattle	NNS
cord-282246-wyanwvxa	254	5	interferon	interferon	NN
cord-282246-wyanwvxa	254	6	-	-	:
cord-282246-wyanwvxa	254	7	A	a	NN
cord-282246-wyanwvxa	254	8	subtypes	subtype	NNS
cord-282246-wyanwvxa	254	9	isolated	isolate	VBN
cord-282246-wyanwvxa	254	10	from	from	IN
cord-282246-wyanwvxa	254	11	the	the	DT
cord-282246-wyanwvxa	254	12	gut	gut	NN
cord-282246-wyanwvxa	254	13	epithelium	epithelium	NN
cord-282246-wyanwvxa	254	14	of	of	IN
cord-282246-wyanwvxa	254	15	rotavirusinfected	rotavirusinfecte	VBN
cord-282246-wyanwvxa	254	16	calves	calf	NNS
cord-282246-wyanwvxa	254	17	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	254	18	induces	induce	VBZ
cord-282246-wyanwvxa	254	19	alphainterferon	alphainterferon	NNP
cord-282246-wyanwvxa	254	20	release	release	NN
cord-282246-wyanwvxa	254	21	in	in	IN
cord-282246-wyanwvxa	254	22	children	child	NNS
cord-282246-wyanwvxa	254	23	with	with	IN
cord-282246-wyanwvxa	254	24	gastroenteritis	gastroenteritis	JJ
cord-282246-wyanwvxa	254	25	Treatment	treatment	NN
cord-282246-wyanwvxa	254	26	of	of	IN
cord-282246-wyanwvxa	254	27	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	254	28	infection	infection	NN
cord-282246-wyanwvxa	254	29	in	in	IN
cord-282246-wyanwvxa	254	30	neonate	neonate	NN
cord-282246-wyanwvxa	254	31	and	and	CC
cord-282246-wyanwvxa	254	32	weanling	weanle	VBG
cord-282246-wyanwvxa	254	33	pigs	pig	NNS
cord-282246-wyanwvxa	254	34	using	use	VBG
cord-282246-wyanwvxa	254	35	natural	natural	JJ
cord-282246-wyanwvxa	254	36	human	human	JJ
cord-282246-wyanwvxa	254	37	interferon	interferon	NNP
cord-282246-wyanwvxa	254	38	alpha	alpha	NN
cord-282246-wyanwvxa	255	1	Interferon	interferon	NN
cord-282246-wyanwvxa	255	2	response	response	NN
cord-282246-wyanwvxa	255	3	in	in	IN
cord-282246-wyanwvxa	255	4	colostrum	colostrum	NN
cord-282246-wyanwvxa	255	5	-	-	HYPH
cord-282246-wyanwvxa	255	6	deprived	deprive	VBN
cord-282246-wyanwvxa	255	7	newborn	newborn	JJ
cord-282246-wyanwvxa	255	8	calves	calf	NNS
cord-282246-wyanwvxa	255	9	infected	infect	VBN
cord-282246-wyanwvxa	255	10	with	with	IN
cord-282246-wyanwvxa	255	11	bovine	bovine	JJ
cord-282246-wyanwvxa	255	12	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	255	13	:	:	:
cord-282246-wyanwvxa	255	14	its	-PRON-	PRP$
cord-282246-wyanwvxa	255	15	possible	possible	JJ
cord-282246-wyanwvxa	255	16	role	role	NN
cord-282246-wyanwvxa	255	17	in	in	IN
cord-282246-wyanwvxa	255	18	the	the	DT
cord-282246-wyanwvxa	255	19	control	control	NN
cord-282246-wyanwvxa	255	20	of	of	IN
cord-282246-wyanwvxa	255	21	the	the	DT
cord-282246-wyanwvxa	255	22	pathogenicity	pathogenicity	NN
cord-282246-wyanwvxa	255	23	Interferon	Interferon	NNP
cord-282246-wyanwvxa	255	24	activity	activity	NN
cord-282246-wyanwvxa	255	25	in	in	IN
cord-282246-wyanwvxa	255	26	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	255	27	infected	infect	VBN
cord-282246-wyanwvxa	255	28	newborn	newborn	JJ
cord-282246-wyanwvxa	255	29	calves	calf	NNS
cord-282246-wyanwvxa	256	1	Innate	innate	JJ
cord-282246-wyanwvxa	256	2	immune	immune	JJ
cord-282246-wyanwvxa	256	3	response	response	NN
cord-282246-wyanwvxa	256	4	to	to	IN
cord-282246-wyanwvxa	256	5	homologous	homologous	JJ
cord-282246-wyanwvxa	256	6	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	256	7	infection	infection	NN
cord-282246-wyanwvxa	256	8	in	in	IN
cord-282246-wyanwvxa	256	9	the	the	DT
cord-282246-wyanwvxa	256	10	small	small	JJ
cord-282246-wyanwvxa	256	11	intestinal	intestinal	JJ
cord-282246-wyanwvxa	256	12	villous	villous	NN
cord-282246-wyanwvxa	256	13	epithelium	epithelium	NN
cord-282246-wyanwvxa	256	14	at	at	IN
cord-282246-wyanwvxa	256	15	single	single	JJ
cord-282246-wyanwvxa	256	16	-	-	HYPH
cord-282246-wyanwvxa	256	17	cell	cell	NN
cord-282246-wyanwvxa	256	18	resolution	resolution	NN
cord-282246-wyanwvxa	257	1	Plasmacytoid	Plasmacytoid	NNP
cord-282246-wyanwvxa	257	2	dendritic	dendritic	JJ
cord-282246-wyanwvxa	257	3	cells	cell	NNS
cord-282246-wyanwvxa	257	4	promote	promote	VBP
cord-282246-wyanwvxa	257	5	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	257	6	-	-	HYPH
cord-282246-wyanwvxa	257	7	induced	induce	VBN
cord-282246-wyanwvxa	257	8	human	human	NN
cord-282246-wyanwvxa	257	9	and	and	CC
cord-282246-wyanwvxa	257	10	murine	murine	JJ
cord-282246-wyanwvxa	257	11	B	b	NN
cord-282246-wyanwvxa	257	12	cell	cell	NN
cord-282246-wyanwvxa	257	13	responses	response	NNS
cord-282246-wyanwvxa	257	14	Role	role	NN
cord-282246-wyanwvxa	257	15	of	of	IN
cord-282246-wyanwvxa	257	16	interferon	interferon	NN
cord-282246-wyanwvxa	257	17	regulatory	regulatory	JJ
cord-282246-wyanwvxa	257	18	factor	factor	NN
cord-282246-wyanwvxa	257	19	3	3	CD
cord-282246-wyanwvxa	257	20	in	in	IN
cord-282246-wyanwvxa	257	21	type	type	NN
cord-282246-wyanwvxa	258	1	I	-PRON-	PRP
cord-282246-wyanwvxa	259	1	interferon	interferon	NN
cord-282246-wyanwvxa	259	2	responses	response	NNS
cord-282246-wyanwvxa	259	3	in	in	IN
cord-282246-wyanwvxa	259	4	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	259	5	-	-	HYPH
cord-282246-wyanwvxa	259	6	infected	infect	VBN
cord-282246-wyanwvxa	259	7	dendritic	dendritic	JJ
cord-282246-wyanwvxa	259	8	cells	cell	NNS
cord-282246-wyanwvxa	259	9	and	and	CC
cord-282246-wyanwvxa	259	10	fibroblasts	fibroblast	NNS
cord-282246-wyanwvxa	259	11	Flagellin	flagellin	JJ
cord-282246-wyanwvxa	259	12	treatment	treatment	NN
cord-282246-wyanwvxa	259	13	protects	protect	VBZ
cord-282246-wyanwvxa	259	14	against	against	IN
cord-282246-wyanwvxa	259	15	chemicals	chemical	NNS
cord-282246-wyanwvxa	259	16	,	,	,
cord-282246-wyanwvxa	259	17	bacteria	bacteria	NNS
cord-282246-wyanwvxa	259	18	,	,	,
cord-282246-wyanwvxa	259	19	viruses	virus	NNS
cord-282246-wyanwvxa	259	20	,	,	,
cord-282246-wyanwvxa	259	21	and	and	CC
cord-282246-wyanwvxa	259	22	radiation	radiation	NN
cord-282246-wyanwvxa	259	23	Interferon	interferon	NN
cord-282246-wyanwvxa	259	24	-	-	HYPH
cord-282246-wyanwvxa	259	25	lambda	lambda	NN
cord-282246-wyanwvxa	259	26	and	and	CC
cord-282246-wyanwvxa	259	27	interleukin	interleukin	NN
cord-282246-wyanwvxa	259	28	22	22	CD
cord-282246-wyanwvxa	259	29	act	act	NN
cord-282246-wyanwvxa	259	30	synergistically	synergistically	RB
cord-282246-wyanwvxa	259	31	for	for	IN
cord-282246-wyanwvxa	259	32	the	the	DT
cord-282246-wyanwvxa	259	33	induction	induction	NN
cord-282246-wyanwvxa	259	34	of	of	IN
cord-282246-wyanwvxa	259	35	interferon	interferon	NN
cord-282246-wyanwvxa	259	36	-	-	HYPH
cord-282246-wyanwvxa	259	37	stimulated	stimulate	VBN
cord-282246-wyanwvxa	259	38	genes	gene	NNS
cord-282246-wyanwvxa	259	39	and	and	CC
cord-282246-wyanwvxa	259	40	control	control	NN
cord-282246-wyanwvxa	259	41	of	of	IN
cord-282246-wyanwvxa	259	42	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	259	43	infection	infection	NN
cord-282246-wyanwvxa	260	1	The	the	DT
cord-282246-wyanwvxa	260	2	inflammasomes	inflammasome	NNS
cord-282246-wyanwvxa	261	1	Inflammasome	Inflammasome	NNP
cord-282246-wyanwvxa	261	2	-	-	HYPH
cord-282246-wyanwvxa	261	3	activated	activate	VBN
cord-282246-wyanwvxa	261	4	gasdermin	gasdermin	NNP
cord-282246-wyanwvxa	261	5	D	D	NNP
cord-282246-wyanwvxa	261	6	causes	cause	VBZ
cord-282246-wyanwvxa	261	7	pyroptosis	pyroptosis	NN
cord-282246-wyanwvxa	261	8	by	by	IN
cord-282246-wyanwvxa	261	9	forming	form	VBG
cord-282246-wyanwvxa	261	10	membrane	membrane	NN
cord-282246-wyanwvxa	261	11	pores	pore	VBZ
cord-282246-wyanwvxa	261	12	Inflammatory	inflammatory	JJ
cord-282246-wyanwvxa	261	13	bowel	bowel	NN
cord-282246-wyanwvxa	261	14	disease	disease	NN
cord-282246-wyanwvxa	261	15	and	and	CC
cord-282246-wyanwvxa	261	16	the	the	DT
cord-282246-wyanwvxa	261	17	NLRP3	NLRP3	NNP
cord-282246-wyanwvxa	261	18	inflammasome	inflammasome	NNP
cord-282246-wyanwvxa	262	1	The	the	DT
cord-282246-wyanwvxa	262	2	AIM2	AIM2	NNP
cord-282246-wyanwvxa	262	3	inflammasome	inflammasome	NN
cord-282246-wyanwvxa	262	4	is	be	VBZ
cord-282246-wyanwvxa	262	5	essential	essential	JJ
cord-282246-wyanwvxa	262	6	for	for	IN
cord-282246-wyanwvxa	262	7	host	host	NN
cord-282246-wyanwvxa	262	8	defense	defense	NN
cord-282246-wyanwvxa	262	9	against	against	IN
cord-282246-wyanwvxa	262	10	cytosolic	cytosolic	JJ
cord-282246-wyanwvxa	262	11	bacteria	bacteria	NNS
cord-282246-wyanwvxa	262	12	and	and	CC
cord-282246-wyanwvxa	262	13	DNA	dna	NN
cord-282246-wyanwvxa	262	14	viruses	virus	NNS
cord-282246-wyanwvxa	263	1	K(1	k(1	LS
cord-282246-wyanwvxa	263	2	)	)	-RRB-
cord-282246-wyanwvxa	263	3	efflux	efflux	NN
cord-282246-wyanwvxa	263	4	is	be	VBZ
cord-282246-wyanwvxa	263	5	the	the	DT
cord-282246-wyanwvxa	263	6	common	common	JJ
cord-282246-wyanwvxa	263	7	trigger	trigger	NN
cord-282246-wyanwvxa	263	8	of	of	IN
cord-282246-wyanwvxa	263	9	NLRP3	NLRP3	NNP
cord-282246-wyanwvxa	263	10	inflammasome	inflammasome	NNP
cord-282246-wyanwvxa	263	11	activation	activation	NN
cord-282246-wyanwvxa	263	12	by	by	IN
cord-282246-wyanwvxa	263	13	bacterial	bacterial	JJ
cord-282246-wyanwvxa	263	14	toxins	toxin	NNS
cord-282246-wyanwvxa	263	15	and	and	CC
cord-282246-wyanwvxa	263	16	particulate	particulate	NN
cord-282246-wyanwvxa	263	17	matter	matter	NN
cord-282246-wyanwvxa	264	1	Nlrp9b	Nlrp9b	NNP
cord-282246-wyanwvxa	264	2	inflammasome	inflammasome	NNP
cord-282246-wyanwvxa	264	3	restricts	restrict	VBZ
cord-282246-wyanwvxa	264	4	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	264	5	infection	infection	NN
cord-282246-wyanwvxa	264	6	in	in	IN
cord-282246-wyanwvxa	264	7	intestinal	intestinal	JJ
cord-282246-wyanwvxa	264	8	epithelial	epithelial	JJ
cord-282246-wyanwvxa	264	9	cells	cell	NNS
cord-282246-wyanwvxa	264	10	Global	global	JJ
cord-282246-wyanwvxa	264	11	impact	impact	NN
cord-282246-wyanwvxa	264	12	of	of	IN
cord-282246-wyanwvxa	264	13	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	264	14	vaccination	vaccination	NN
cord-282246-wyanwvxa	264	15	on	on	IN
cord-282246-wyanwvxa	264	16	childhood	childhood	NN
cord-282246-wyanwvxa	264	17	hospitalizations	hospitalization	NNS
cord-282246-wyanwvxa	264	18	and	and	CC
cord-282246-wyanwvxa	264	19	mortality	mortality	NN
cord-282246-wyanwvxa	264	20	from	from	IN
cord-282246-wyanwvxa	264	21	diarrhea	diarrhea	NN
cord-282246-wyanwvxa	264	22	Roles	role	NNS
cord-282246-wyanwvxa	264	23	of	of	IN
cord-282246-wyanwvxa	264	24	VP4	VP4	NNP
cord-282246-wyanwvxa	264	25	and	and	CC
cord-282246-wyanwvxa	264	26	NSP1	NSP1	NNP
cord-282246-wyanwvxa	264	27	in	in	IN
cord-282246-wyanwvxa	264	28	determining	determine	VBG
cord-282246-wyanwvxa	264	29	the	the	DT
cord-282246-wyanwvxa	264	30	distinctive	distinctive	JJ
cord-282246-wyanwvxa	264	31	replication	replication	NN
cord-282246-wyanwvxa	264	32	capacities	capacity	NNS
cord-282246-wyanwvxa	264	33	of	of	IN
cord-282246-wyanwvxa	264	34	simian	simian	JJ
cord-282246-wyanwvxa	264	35	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	264	36	RRV	RRV	NNP
cord-282246-wyanwvxa	264	37	and	and	CC
cord-282246-wyanwvxa	264	38	bovine	bovine	JJ
cord-282246-wyanwvxa	264	39	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	264	40	UK	UK	NNP
cord-282246-wyanwvxa	264	41	in	in	IN
cord-282246-wyanwvxa	264	42	the	the	DT
cord-282246-wyanwvxa	264	43	mouse	mouse	NN
cord-282246-wyanwvxa	264	44	biliary	biliary	JJ
cord-282246-wyanwvxa	264	45	tract	tract	NN
cord-282246-wyanwvxa	264	46	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	264	47	infection	infection	NN
cord-282246-wyanwvxa	264	48	Diversity	diversity	NN
cord-282246-wyanwvxa	264	49	of	of	IN
cord-282246-wyanwvxa	264	50	interferon	interferon	NN
cord-282246-wyanwvxa	264	51	antagonist	antagonist	NN
cord-282246-wyanwvxa	264	52	activities	activity	NNS
cord-282246-wyanwvxa	264	53	mediated	mediate	VBN
cord-282246-wyanwvxa	264	54	by	by	IN
cord-282246-wyanwvxa	264	55	NSP1	NSP1	NNP
cord-282246-wyanwvxa	264	56	proteins	protein	NNS
cord-282246-wyanwvxa	264	57	of	of	IN
cord-282246-wyanwvxa	264	58	different	different	JJ
cord-282246-wyanwvxa	264	59	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	264	60	strains	strain	NNS
cord-282246-wyanwvxa	265	1	The	the	DT
cord-282246-wyanwvxa	265	2	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	265	3	interferon	interferon	NN
cord-282246-wyanwvxa	265	4	antagonist	antagonist	NN
cord-282246-wyanwvxa	265	5	NSP1	NSP1	NNP
cord-282246-wyanwvxa	265	6	:	:	:
cord-282246-wyanwvxa	265	7	many	many	JJ
cord-282246-wyanwvxa	265	8	targets	target	NNS
cord-282246-wyanwvxa	265	9	,	,	,
cord-282246-wyanwvxa	265	10	many	many	JJ
cord-282246-wyanwvxa	265	11	questions	question	NNS
cord-282246-wyanwvxa	265	12	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	265	13	NSP1	NSP1	NNP
cord-282246-wyanwvxa	265	14	mediates	mediate	VBZ
cord-282246-wyanwvxa	265	15	degradation	degradation	NN
cord-282246-wyanwvxa	265	16	of	of	IN
cord-282246-wyanwvxa	265	17	interferon	interferon	NN
cord-282246-wyanwvxa	265	18	regulatory	regulatory	JJ
cord-282246-wyanwvxa	265	19	factors	factor	NNS
cord-282246-wyanwvxa	265	20	through	through	IN
cord-282246-wyanwvxa	265	21	targeting	target	VBG
cord-282246-wyanwvxa	265	22	of	of	IN
cord-282246-wyanwvxa	265	23	the	the	DT
cord-282246-wyanwvxa	265	24	dimerization	dimerization	NN
cord-282246-wyanwvxa	265	25	domain	domain	NN
cord-282246-wyanwvxa	265	26	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	265	27	NSP1	NSP1	NNP
cord-282246-wyanwvxa	265	28	inhibits	inhibit	VBZ
cord-282246-wyanwvxa	265	29	expression	expression	NN
cord-282246-wyanwvxa	265	30	of	of	IN
cord-282246-wyanwvxa	265	31	type	type	NN
cord-282246-wyanwvxa	266	1	I	-PRON-	PRP
cord-282246-wyanwvxa	266	2	interferon	interferon	RB
cord-282246-wyanwvxa	266	3	by	by	IN
cord-282246-wyanwvxa	266	4	antagonizing	antagonize	VBG
cord-282246-wyanwvxa	266	5	the	the	DT
cord-282246-wyanwvxa	266	6	function	function	NN
cord-282246-wyanwvxa	266	7	of	of	IN
cord-282246-wyanwvxa	266	8	interferon	interferon	NN
cord-282246-wyanwvxa	266	9	regulatory	regulatory	JJ
cord-282246-wyanwvxa	266	10	factors	factor	NNS
cord-282246-wyanwvxa	266	11	IRF3	IRF3	NNP
cord-282246-wyanwvxa	266	12	,	,	,
cord-282246-wyanwvxa	266	13	IRF5	IRF5	NNP
cord-282246-wyanwvxa	266	14	,	,	,
cord-282246-wyanwvxa	266	15	and	and	CC
cord-282246-wyanwvxa	266	16	IRF7	IRF7	NNP
cord-282246-wyanwvxa	267	1	Comparative	comparative	JJ
cord-282246-wyanwvxa	267	2	proteomics	proteomic	NNS
cord-282246-wyanwvxa	267	3	reveals	reveal	VBZ
cord-282246-wyanwvxa	267	4	strainspecific	strainspecific	JJ
cord-282246-wyanwvxa	267	5	beta	beta	NN
cord-282246-wyanwvxa	267	6	-	-	HYPH
cord-282246-wyanwvxa	267	7	TrCP	trcp	NN
cord-282246-wyanwvxa	267	8	degradation	degradation	NN
cord-282246-wyanwvxa	267	9	via	via	IN
cord-282246-wyanwvxa	267	10	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	267	11	NSP1	NSP1	NNP
cord-282246-wyanwvxa	267	12	hijacking	hijacking	NN
cord-282246-wyanwvxa	267	13	a	a	DT
cord-282246-wyanwvxa	267	14	host	host	NN
cord-282246-wyanwvxa	267	15	cullin-3-Rbx1	cullin-3-rbx1	CD
cord-282246-wyanwvxa	267	16	complex	complex	JJ
cord-282246-wyanwvxa	267	17	Rotavirus	rotavirus	NN
cord-282246-wyanwvxa	267	18	NSP1	NSP1	NNP
cord-282246-wyanwvxa	268	1	inhibits	inhibit	VBZ
cord-282246-wyanwvxa	268	2	NFkappaB	NFkappaB	NNP
cord-282246-wyanwvxa	268	3	activation	activation	NN
cord-282246-wyanwvxa	268	4	by	by	IN
cord-282246-wyanwvxa	268	5	inducing	induce	VBG
cord-282246-wyanwvxa	268	6	proteasome	proteasome	VBN
cord-282246-wyanwvxa	268	7	-	-	HYPH
cord-282246-wyanwvxa	268	8	dependent	dependent	JJ
cord-282246-wyanwvxa	268	9	degradation	degradation	NN
cord-282246-wyanwvxa	268	10	of	of	IN
cord-282246-wyanwvxa	268	11	beta	beta	NN
cord-282246-wyanwvxa	268	12	-	-	HYPH
cord-282246-wyanwvxa	268	13	TrCP	trcp	NN
cord-282246-wyanwvxa	268	14	:	:	:
cord-282246-wyanwvxa	269	1	a	a	DT
cord-282246-wyanwvxa	269	2	novel	novel	JJ
cord-282246-wyanwvxa	269	3	mechanism	mechanism	NN
cord-282246-wyanwvxa	269	4	of	of	IN
cord-282246-wyanwvxa	269	5	IFN	IFN	NNP
cord-282246-wyanwvxa	269	6	antagonism	antagonism	NN
cord-282246-wyanwvxa	269	7	Zinc	zinc	NN
cord-282246-wyanwvxa	269	8	-	-	HYPH
cord-282246-wyanwvxa	269	9	binding	bind	VBG
cord-282246-wyanwvxa	269	10	domain	domain	NN
cord-282246-wyanwvxa	269	11	of	of	IN
cord-282246-wyanwvxa	269	12	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	269	13	NSP1	NSP1	NNP
cord-282246-wyanwvxa	269	14	is	be	VBZ
cord-282246-wyanwvxa	269	15	required	require	VBN
cord-282246-wyanwvxa	269	16	for	for	IN
cord-282246-wyanwvxa	269	17	proteasome	proteasome	VBN
cord-282246-wyanwvxa	269	18	-	-	HYPH
cord-282246-wyanwvxa	269	19	dependent	dependent	JJ
cord-282246-wyanwvxa	269	20	degradation	degradation	NN
cord-282246-wyanwvxa	269	21	of	of	IN
cord-282246-wyanwvxa	269	22	IRF3	IRF3	NNP
cord-282246-wyanwvxa	269	23	and	and	CC
cord-282246-wyanwvxa	269	24	autoregulatory	autoregulatory	NNP
cord-282246-wyanwvxa	269	25	NSP1	NSP1	NNP
cord-282246-wyanwvxa	269	26	stability	stability	NN
cord-282246-wyanwvxa	270	1	Interferon	interferon	NN
cord-282246-wyanwvxa	270	2	regulatory	regulatory	JJ
cord-282246-wyanwvxa	270	3	factor	factor	NN
cord-282246-wyanwvxa	270	4	3	3	CD
cord-282246-wyanwvxa	270	5	is	be	VBZ
cord-282246-wyanwvxa	270	6	a	a	DT
cord-282246-wyanwvxa	270	7	cellular	cellular	JJ
cord-282246-wyanwvxa	270	8	partner	partner	NN
cord-282246-wyanwvxa	270	9	of	of	IN
cord-282246-wyanwvxa	270	10	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	270	11	NSP1	NSP1	NNP
cord-282246-wyanwvxa	270	12	NSP1	NSP1	NNP
cord-282246-wyanwvxa	270	13	of	of	IN
cord-282246-wyanwvxa	270	14	human	human	JJ
cord-282246-wyanwvxa	270	15	rotaviruses	rotavirus	NNS
cord-282246-wyanwvxa	270	16	commonly	commonly	RB
cord-282246-wyanwvxa	270	17	inhibits	inhibit	VBZ
cord-282246-wyanwvxa	270	18	NF	nf	NN
cord-282246-wyanwvxa	270	19	-	-	HYPH
cord-282246-wyanwvxa	270	20	kappaB	kappaB	NNP
cord-282246-wyanwvxa	270	21	signalling	signal	VBG
cord-282246-wyanwvxa	270	22	by	by	IN
cord-282246-wyanwvxa	270	23	inducing	induce	VBG
cord-282246-wyanwvxa	270	24	beta	beta	NN
cord-282246-wyanwvxa	270	25	-	-	HYPH
cord-282246-wyanwvxa	270	26	TrCP	trcp	NN
cord-282246-wyanwvxa	270	27	degradation	degradation	NN
cord-282246-wyanwvxa	271	1	IRF3	irf3	CD
cord-282246-wyanwvxa	271	2	inhibition	inhibition	NN
cord-282246-wyanwvxa	271	3	by	by	IN
cord-282246-wyanwvxa	271	4	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	271	5	NSP1	NSP1	NNP
cord-282246-wyanwvxa	271	6	is	be	VBZ
cord-282246-wyanwvxa	272	1	host	host	NN
cord-282246-wyanwvxa	272	2	cell	cell	NN
cord-282246-wyanwvxa	272	3	and	and	CC
cord-282246-wyanwvxa	272	4	virus	virus	NN
cord-282246-wyanwvxa	272	5	strain	strain	VBP
cord-282246-wyanwvxa	272	6	dependent	dependent	JJ
cord-282246-wyanwvxa	272	7	but	but	CC
cord-282246-wyanwvxa	272	8	independent	independent	JJ
cord-282246-wyanwvxa	272	9	of	of	IN
cord-282246-wyanwvxa	273	1	NSP1	NSP1	NNP
cord-282246-wyanwvxa	273	2	proteasomal	proteasomal	JJ
cord-282246-wyanwvxa	273	3	degradation	degradation	NN
cord-282246-wyanwvxa	273	4	Role	role	NN
cord-282246-wyanwvxa	273	5	of	of	IN
cord-282246-wyanwvxa	273	6	interferon	interferon	NN
cord-282246-wyanwvxa	273	7	in	in	IN
cord-282246-wyanwvxa	273	8	homologous	homologous	JJ
cord-282246-wyanwvxa	273	9	and	and	CC
cord-282246-wyanwvxa	273	10	heterologous	heterologous	JJ
cord-282246-wyanwvxa	273	11	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	273	12	infection	infection	NN
cord-282246-wyanwvxa	273	13	in	in	IN
cord-282246-wyanwvxa	273	14	the	the	DT
cord-282246-wyanwvxa	273	15	intestines	intestine	NNS
cord-282246-wyanwvxa	273	16	and	and	CC
cord-282246-wyanwvxa	273	17	extraintestinal	extraintestinal	JJ
cord-282246-wyanwvxa	273	18	organs	organ	NNS
cord-282246-wyanwvxa	273	19	of	of	IN
cord-282246-wyanwvxa	273	20	suckling	suckle	VBG
cord-282246-wyanwvxa	273	21	mice	mouse	NNS
cord-282246-wyanwvxa	273	22	Permissive	permissive	JJ
cord-282246-wyanwvxa	273	23	replication	replication	NN
cord-282246-wyanwvxa	273	24	of	of	IN
cord-282246-wyanwvxa	273	25	homologous	homologous	JJ
cord-282246-wyanwvxa	273	26	murine	murine	JJ
cord-282246-wyanwvxa	273	27	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	273	28	in	in	IN
cord-282246-wyanwvxa	273	29	the	the	DT
cord-282246-wyanwvxa	273	30	mouse	mouse	NN
cord-282246-wyanwvxa	273	31	intestine	intestine	NN
cord-282246-wyanwvxa	273	32	is	be	VBZ
cord-282246-wyanwvxa	273	33	primarily	primarily	RB
cord-282246-wyanwvxa	273	34	regulated	regulate	VBN
cord-282246-wyanwvxa	273	35	by	by	IN
cord-282246-wyanwvxa	273	36	VP4	VP4	NNP
cord-282246-wyanwvxa	273	37	and	and	CC
cord-282246-wyanwvxa	273	38	NSP1	NSP1	NNP
cord-282246-wyanwvxa	273	39	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	273	40	degrades	degrade	VBZ
cord-282246-wyanwvxa	273	41	multiple	multiple	JJ
cord-282246-wyanwvxa	273	42	type	type	NN
cord-282246-wyanwvxa	273	43	interferon	interferon	NN
cord-282246-wyanwvxa	273	44	receptors	receptor	NNS
cord-282246-wyanwvxa	273	45	to	to	TO
cord-282246-wyanwvxa	273	46	inhibit	inhibit	VB
cord-282246-wyanwvxa	273	47	IFN	IFN	NNP
cord-282246-wyanwvxa	273	48	signaling	signal	VBG
cord-282246-wyanwvxa	273	49	and	and	CC
cord-282246-wyanwvxa	273	50	protects	protect	VBZ
cord-282246-wyanwvxa	273	51	against	against	IN
cord-282246-wyanwvxa	273	52	mortality	mortality	NN
cord-282246-wyanwvxa	273	53	from	from	IN
cord-282246-wyanwvxa	273	54	endotoxin	endotoxin	NN
cord-282246-wyanwvxa	273	55	in	in	IN
cord-282246-wyanwvxa	273	56	suckling	suckle	VBG
cord-282246-wyanwvxa	273	57	mice	mice	NN
cord-282246-wyanwvxa	273	58	Variation	variation	NN
cord-282246-wyanwvxa	273	59	in	in	IN
cord-282246-wyanwvxa	273	60	antagonism	antagonism	NN
cord-282246-wyanwvxa	273	61	of	of	IN
cord-282246-wyanwvxa	273	62	the	the	DT
cord-282246-wyanwvxa	273	63	interferon	interferon	NN
cord-282246-wyanwvxa	273	64	response	response	NN
cord-282246-wyanwvxa	273	65	to	to	TO
cord-282246-wyanwvxa	273	66	rotavirus	rotavirus	VB
cord-282246-wyanwvxa	273	67	NSP1	NSP1	NNP
cord-282246-wyanwvxa	273	68	results	result	NNS
cord-282246-wyanwvxa	273	69	in	in	IN
cord-282246-wyanwvxa	273	70	differential	differential	JJ
cord-282246-wyanwvxa	273	71	infectivity	infectivity	NN
cord-282246-wyanwvxa	273	72	in	in	IN
cord-282246-wyanwvxa	273	73	mouse	mouse	NN
cord-282246-wyanwvxa	273	74	embryonic	embryonic	JJ
cord-282246-wyanwvxa	273	75	fibroblasts	fibroblast	NNS
cord-282246-wyanwvxa	274	1	IPS-1	IPS-1	NNP
cord-282246-wyanwvxa	274	2	,	,	,
cord-282246-wyanwvxa	274	3	an	an	DT
cord-282246-wyanwvxa	274	4	adaptor	adaptor	NN
cord-282246-wyanwvxa	274	5	triggering	trigger	VBG
cord-282246-wyanwvxa	274	6	RIG	rig	NN
cord-282246-wyanwvxa	274	7	-	-	HYPH
cord-282246-wyanwvxa	274	8	I	i	NN
cord-282246-wyanwvxa	274	9	-	-	HYPH
cord-282246-wyanwvxa	274	10	and	and	CC
cord-282246-wyanwvxa	274	11	Mda5-mediated	Mda5-mediated	NNP
cord-282246-wyanwvxa	275	1	type	type	NN
cord-282246-wyanwvxa	276	1	I	-PRON-	PRP
cord-282246-wyanwvxa	277	1	interferon	interferon	NNP
cord-282246-wyanwvxa	277	2	induction	induction	NN
cord-282246-wyanwvxa	277	3	Cardif	Cardif	NNP
cord-282246-wyanwvxa	277	4	is	be	VBZ
cord-282246-wyanwvxa	277	5	an	an	DT
cord-282246-wyanwvxa	277	6	adaptor	adaptor	NN
cord-282246-wyanwvxa	277	7	protein	protein	NN
cord-282246-wyanwvxa	277	8	in	in	IN
cord-282246-wyanwvxa	277	9	the	the	DT
cord-282246-wyanwvxa	277	10	RIG	rig	NN
cord-282246-wyanwvxa	277	11	-	-	:
cord-282246-wyanwvxa	277	12	I	I	NNP
cord-282246-wyanwvxa	277	13	antiviral	antiviral	JJ
cord-282246-wyanwvxa	277	14	pathway	pathway	NN
cord-282246-wyanwvxa	277	15	and	and	CC
cord-282246-wyanwvxa	277	16	is	be	VBZ
cord-282246-wyanwvxa	277	17	targeted	target	VBN
cord-282246-wyanwvxa	277	18	by	by	IN
cord-282246-wyanwvxa	277	19	hepatitis	hepatitis	NN
cord-282246-wyanwvxa	277	20	C	C	NNP
cord-282246-wyanwvxa	277	21	virus	virus	NN
cord-282246-wyanwvxa	277	22	Identification	identification	NN
cord-282246-wyanwvxa	277	23	and	and	CC
cord-282246-wyanwvxa	277	24	characterization	characterization	NN
cord-282246-wyanwvxa	277	25	of	of	IN
cord-282246-wyanwvxa	277	26	MAVS	MAVS	NNPS
cord-282246-wyanwvxa	277	27	,	,	,
cord-282246-wyanwvxa	277	28	a	a	DT
cord-282246-wyanwvxa	277	29	mitochondrial	mitochondrial	JJ
cord-282246-wyanwvxa	277	30	antiviral	antiviral	JJ
cord-282246-wyanwvxa	277	31	signaling	signal	VBG
cord-282246-wyanwvxa	277	32	protein	protein	NN
cord-282246-wyanwvxa	277	33	that	that	WDT
cord-282246-wyanwvxa	277	34	activates	activate	VBZ
cord-282246-wyanwvxa	277	35	NF	NF	NNP
cord-282246-wyanwvxa	277	36	-	-	HYPH
cord-282246-wyanwvxa	277	37	kappaB	kappaB	NNP
cord-282246-wyanwvxa	277	38	and	and	CC
cord-282246-wyanwvxa	277	39	IRF	IRF	NNP
cord-282246-wyanwvxa	277	40	3	3	CD
cord-282246-wyanwvxa	277	41	VISA	VISA	NNP
cord-282246-wyanwvxa	277	42	is	be	VBZ
cord-282246-wyanwvxa	277	43	an	an	DT
cord-282246-wyanwvxa	277	44	adapter	adapter	NN
cord-282246-wyanwvxa	277	45	protein	protein	NN
cord-282246-wyanwvxa	277	46	required	require	VBN
cord-282246-wyanwvxa	277	47	for	for	IN
cord-282246-wyanwvxa	277	48	virus	virus	NN
cord-282246-wyanwvxa	277	49	-	-	HYPH
cord-282246-wyanwvxa	277	50	triggered	trigger	VBN
cord-282246-wyanwvxa	277	51	IFN	IFN	NNP
cord-282246-wyanwvxa	277	52	-	-	HYPH
cord-282246-wyanwvxa	277	53	beta	beta	NN
cord-282246-wyanwvxa	277	54	signaling	signal	VBG
cord-282246-wyanwvxa	277	55	Phosphorylation	Phosphorylation	NNP
cord-282246-wyanwvxa	277	56	of	of	IN
cord-282246-wyanwvxa	277	57	innate	innate	JJ
cord-282246-wyanwvxa	277	58	immune	immune	JJ
cord-282246-wyanwvxa	277	59	adaptor	adaptor	NN
cord-282246-wyanwvxa	277	60	proteins	protein	NNS
cord-282246-wyanwvxa	277	61	MAVS	mavs	RB
cord-282246-wyanwvxa	277	62	,	,	,
cord-282246-wyanwvxa	277	63	STING	sting	NN
cord-282246-wyanwvxa	277	64	,	,	,
cord-282246-wyanwvxa	277	65	and	and	CC
cord-282246-wyanwvxa	277	66	TRIF	TRIF	NNP
cord-282246-wyanwvxa	277	67	induces	induce	VBZ
cord-282246-wyanwvxa	277	68	IRF3	IRF3	NNP
cord-282246-wyanwvxa	277	69	activation	activation	NN
cord-282246-wyanwvxa	278	1	IRF-7	IRF-7	NNP
cord-282246-wyanwvxa	278	2	is	be	VBZ
cord-282246-wyanwvxa	278	3	the	the	DT
cord-282246-wyanwvxa	278	4	master	master	NN
cord-282246-wyanwvxa	278	5	regulator	regulator	NN
cord-282246-wyanwvxa	278	6	of	of	IN
cord-282246-wyanwvxa	278	7	type	type	NN
cord-282246-wyanwvxa	278	8	-	-	:
cord-282246-wyanwvxa	278	9	I	-PRON-	PRP
cord-282246-wyanwvxa	278	10	interferon	interferon	NN
cord-282246-wyanwvxa	278	11	-	-	HYPH
cord-282246-wyanwvxa	278	12	dependent	dependent	JJ
cord-282246-wyanwvxa	278	13	immune	immune	JJ
cord-282246-wyanwvxa	278	14	responses	response	NNS
cord-282246-wyanwvxa	279	1	Rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	279	2	nonstructural	nonstructural	JJ
cord-282246-wyanwvxa	279	3	protein	protein	NN
cord-282246-wyanwvxa	279	4	1	1	CD
cord-282246-wyanwvxa	279	5	subverts	subvert	VBZ
cord-282246-wyanwvxa	279	6	innate	innate	JJ
cord-282246-wyanwvxa	279	7	immune	immune	JJ
cord-282246-wyanwvxa	279	8	response	response	NN
cord-282246-wyanwvxa	279	9	by	by	IN
cord-282246-wyanwvxa	279	10	inducing	induce	VBG
cord-282246-wyanwvxa	279	11	degradation	degradation	NN
cord-282246-wyanwvxa	279	12	of	of	IN
cord-282246-wyanwvxa	279	13	IFN	IFN	NNP
cord-282246-wyanwvxa	279	14	regulatory	regulatory	JJ
cord-282246-wyanwvxa	279	15	factor	factor	NN
cord-282246-wyanwvxa	279	16	3	3	CD
cord-282246-wyanwvxa	279	17	Structural	structural	JJ
cord-282246-wyanwvxa	279	18	basis	basis	NN
cord-282246-wyanwvxa	279	19	for	for	IN
cord-282246-wyanwvxa	279	20	concerted	concerted	JJ
cord-282246-wyanwvxa	279	21	recruitment	recruitment	NN
cord-282246-wyanwvxa	279	22	and	and	CC
cord-282246-wyanwvxa	279	23	activation	activation	NN
cord-282246-wyanwvxa	279	24	of	of	IN
cord-282246-wyanwvxa	279	25	IRF-3	IRF-3	NNP
cord-282246-wyanwvxa	279	26	by	by	IN
cord-282246-wyanwvxa	280	1	innate	innate	JJ
cord-282246-wyanwvxa	280	2	immune	immune	JJ
cord-282246-wyanwvxa	280	3	adaptor	adaptor	NN
cord-282246-wyanwvxa	280	4	proteins	protein	NNS
cord-282246-wyanwvxa	280	5	TNF	TNF	NNP
cord-282246-wyanwvxa	280	6	-	-	HYPH
cord-282246-wyanwvxa	280	7	alpha	alpha	NN
cord-282246-wyanwvxa	280	8	exerts	exert	VBZ
cord-282246-wyanwvxa	280	9	potent	potent	JJ
cord-282246-wyanwvxa	280	10	antirotavirus	antirotavirus	JJ
cord-282246-wyanwvxa	280	11	effects	effect	NNS
cord-282246-wyanwvxa	280	12	via	via	IN
cord-282246-wyanwvxa	280	13	the	the	DT
cord-282246-wyanwvxa	280	14	activation	activation	NN
cord-282246-wyanwvxa	280	15	of	of	IN
cord-282246-wyanwvxa	280	16	classical	classical	JJ
cord-282246-wyanwvxa	280	17	NF	nf	NN
cord-282246-wyanwvxa	280	18	-	-	HYPH
cord-282246-wyanwvxa	280	19	kappaB	kappaB	NNP
cord-282246-wyanwvxa	280	20	pathway	pathway	NN
cord-282246-wyanwvxa	280	21	Rotavirus	rotavirus	NN
cord-282246-wyanwvxa	281	1	stimulates	stimulate	NNS
cord-282246-wyanwvxa	282	1	IL-8	IL-8	NNP
cord-282246-wyanwvxa	282	2	secretion	secretion	NN
cord-282246-wyanwvxa	282	3	from	from	IN
cord-282246-wyanwvxa	282	4	cultured	cultured	JJ
cord-282246-wyanwvxa	282	5	epithelial	epithelial	JJ
cord-282246-wyanwvxa	282	6	cells	cell	NNS
cord-282246-wyanwvxa	282	7	Rotavirus	rotavirus	NN
cord-282246-wyanwvxa	282	8	and	and	CC
cord-282246-wyanwvxa	282	9	coxsackievirus	coxsackievirus	NNP
cord-282246-wyanwvxa	282	10	infection	infection	NN
cord-282246-wyanwvxa	282	11	activated	activate	VBD
cord-282246-wyanwvxa	282	12	different	different	JJ
cord-282246-wyanwvxa	282	13	profiles	profile	NNS
cord-282246-wyanwvxa	282	14	of	of	IN
cord-282246-wyanwvxa	282	15	toll	toll	NN
cord-282246-wyanwvxa	282	16	-	-	HYPH
cord-282246-wyanwvxa	282	17	like	like	JJ
cord-282246-wyanwvxa	282	18	receptors	receptor	NNS
cord-282246-wyanwvxa	282	19	and	and	CC
cord-282246-wyanwvxa	282	20	chemokines	chemokine	NNS
cord-282246-wyanwvxa	282	21	in	in	IN
cord-282246-wyanwvxa	282	22	intestinal	intestinal	JJ
cord-282246-wyanwvxa	282	23	epithelial	epithelial	JJ
cord-282246-wyanwvxa	282	24	cells	cell	NNS
cord-282246-wyanwvxa	282	25	Putative	putative	JJ
cord-282246-wyanwvxa	282	26	E3	e3	NN
cord-282246-wyanwvxa	282	27	ubiquitin	ubiquitin	NN
cord-282246-wyanwvxa	282	28	ligase	ligase	NN
cord-282246-wyanwvxa	282	29	of	of	IN
cord-282246-wyanwvxa	282	30	human	human	JJ
cord-282246-wyanwvxa	282	31	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	282	32	inhibits	inhibit	VBZ
cord-282246-wyanwvxa	282	33	NF	nf	NN
cord-282246-wyanwvxa	282	34	-	-	HYPH
cord-282246-wyanwvxa	282	35	kappaB	kappaB	NNP
cord-282246-wyanwvxa	282	36	activation	activation	NN
cord-282246-wyanwvxa	282	37	by	by	IN
cord-282246-wyanwvxa	282	38	using	use	VBG
cord-282246-wyanwvxa	282	39	molecular	molecular	JJ
cord-282246-wyanwvxa	282	40	mimicry	mimicry	NN
cord-282246-wyanwvxa	282	41	to	to	TO
cord-282246-wyanwvxa	282	42	target	target	VB
cord-282246-wyanwvxa	282	43	beta	beta	NN
cord-282246-wyanwvxa	282	44	-	-	HYPH
cord-282246-wyanwvxa	282	45	TrCP	trcp	NN
cord-282246-wyanwvxa	282	46	Silencing	silence	VBG
cord-282246-wyanwvxa	282	47	the	the	DT
cord-282246-wyanwvxa	282	48	alarms	alarm	NNS
cord-282246-wyanwvxa	282	49	:	:	:
cord-282246-wyanwvxa	282	50	innate	innate	JJ
cord-282246-wyanwvxa	282	51	immune	immune	JJ
cord-282246-wyanwvxa	282	52	antagonism	antagonism	NN
cord-282246-wyanwvxa	282	53	by	by	IN
cord-282246-wyanwvxa	282	54	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	282	55	NSP1	NSP1	NNP
cord-282246-wyanwvxa	282	56	and	and	CC
cord-282246-wyanwvxa	282	57	VP3	VP3	NNP
cord-282246-wyanwvxa	282	58	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	282	59	NSP1	NSP1	NNP
cord-282246-wyanwvxa	282	60	protein	protein	NN
cord-282246-wyanwvxa	282	61	inhibits	inhibit	VBZ
cord-282246-wyanwvxa	282	62	interferon	interferon	NN
cord-282246-wyanwvxa	282	63	-	-	HYPH
cord-282246-wyanwvxa	282	64	mediated	mediate	VBN
cord-282246-wyanwvxa	282	65	STAT1	stat1	NN
cord-282246-wyanwvxa	282	66	activation	activation	NN
cord-282246-wyanwvxa	282	67	Interferons	interferon	NNS
cord-282246-wyanwvxa	282	68	and	and	CC
cord-282246-wyanwvxa	282	69	viruses	virus	NNS
cord-282246-wyanwvxa	282	70	:	:	:
cord-282246-wyanwvxa	282	71	an	an	DT
cord-282246-wyanwvxa	282	72	evolutionary	evolutionary	JJ
cord-282246-wyanwvxa	282	73	arms	arm	NNS
cord-282246-wyanwvxa	282	74	race	race	NN
cord-282246-wyanwvxa	282	75	of	of	IN
cord-282246-wyanwvxa	282	76	molecular	molecular	JJ
cord-282246-wyanwvxa	282	77	interactions	interaction	NNS
cord-282246-wyanwvxa	283	1	Interferon	interferon	NN
cord-282246-wyanwvxa	283	2	gamma	gamma	NN
cord-282246-wyanwvxa	283	3	and	and	CC
cord-282246-wyanwvxa	283	4	interleukin	interleukin	NN
cord-282246-wyanwvxa	283	5	1	1	CD
cord-282246-wyanwvxa	283	6	,	,	,
cord-282246-wyanwvxa	283	7	but	but	CC
cord-282246-wyanwvxa	283	8	not	not	RB
cord-282246-wyanwvxa	283	9	interferon	interferon	VBN
cord-282246-wyanwvxa	283	10	alfa	alfa	NNP
cord-282246-wyanwvxa	283	11	,	,	,
cord-282246-wyanwvxa	283	12	inhibit	inhibit	VBP
cord-282246-wyanwvxa	283	13	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	283	14	entry	entry	NN
cord-282246-wyanwvxa	283	15	into	into	IN
cord-282246-wyanwvxa	283	16	human	human	JJ
cord-282246-wyanwvxa	283	17	intestinal	intestinal	JJ
cord-282246-wyanwvxa	283	18	cell	cell	NN
cord-282246-wyanwvxa	283	19	lines	line	NNS
cord-282246-wyanwvxa	284	1	Rotavirus	rotavirus	NN
cord-282246-wyanwvxa	284	2	inhibits	inhibit	VBZ
cord-282246-wyanwvxa	284	3	IFN	IFN	NNP
cord-282246-wyanwvxa	284	4	-	-	HYPH
cord-282246-wyanwvxa	284	5	induced	induce	VBN
cord-282246-wyanwvxa	284	6	STAT	stat	NN
cord-282246-wyanwvxa	284	7	nuclear	nuclear	JJ
cord-282246-wyanwvxa	284	8	translocation	translocation	NN
cord-282246-wyanwvxa	284	9	by	by	IN
cord-282246-wyanwvxa	284	10	a	a	DT
cord-282246-wyanwvxa	284	11	mechanism	mechanism	NN
cord-282246-wyanwvxa	284	12	that	that	WDT
cord-282246-wyanwvxa	284	13	acts	act	VBZ
cord-282246-wyanwvxa	284	14	after	after	IN
cord-282246-wyanwvxa	284	15	STAT	stat	NN
cord-282246-wyanwvxa	284	16	binding	bind	VBG
cord-282246-wyanwvxa	284	17	to	to	IN
cord-282246-wyanwvxa	284	18	importin	importin	JJ
cord-282246-wyanwvxa	284	19	-	-	HYPH
cord-282246-wyanwvxa	284	20	alpha	alpha	NN
cord-282246-wyanwvxa	284	21	Rotavirus	rotavirus	NN
cord-282246-wyanwvxa	284	22	antagonizes	antagonize	VBZ
cord-282246-wyanwvxa	284	23	cellular	cellular	JJ
cord-282246-wyanwvxa	284	24	antiviral	antiviral	JJ
cord-282246-wyanwvxa	284	25	responses	response	NNS
cord-282246-wyanwvxa	284	26	by	by	IN
cord-282246-wyanwvxa	284	27	inhibiting	inhibit	VBG
cord-282246-wyanwvxa	284	28	the	the	DT
cord-282246-wyanwvxa	284	29	nuclear	nuclear	JJ
cord-282246-wyanwvxa	284	30	accumulation	accumulation	NN
cord-282246-wyanwvxa	284	31	of	of	IN
cord-282246-wyanwvxa	284	32	STAT1	stat1	NN
cord-282246-wyanwvxa	284	33	,	,	,
cord-282246-wyanwvxa	284	34	STAT2	STAT2	NNS
cord-282246-wyanwvxa	284	35	,	,	,
cord-282246-wyanwvxa	284	36	and	and	CC
cord-282246-wyanwvxa	284	37	NF	NF	NNP
cord-282246-wyanwvxa	284	38	-	-	HYPH
cord-282246-wyanwvxa	284	39	kappaB	kappaB	NNP
cord-282246-wyanwvxa	284	40	Viral	viral	JJ
cord-282246-wyanwvxa	284	41	encounters	encounter	VBZ
cord-282246-wyanwvxa	284	42	with	with	IN
cord-282246-wyanwvxa	284	43	2',5'-oligoadenylate	2',5'-oligoadenylate	CD
cord-282246-wyanwvxa	284	44	synthetase	synthetase	NN
cord-282246-wyanwvxa	284	45	and	and	CC
cord-282246-wyanwvxa	284	46	RNase	RNase	NNP
cord-282246-wyanwvxa	284	47	L	L	NNP
cord-282246-wyanwvxa	284	48	during	during	IN
cord-282246-wyanwvxa	284	49	the	the	DT
cord-282246-wyanwvxa	284	50	interferon	interferon	NN
cord-282246-wyanwvxa	284	51	antiviral	antiviral	JJ
cord-282246-wyanwvxa	284	52	response	response	NN
cord-282246-wyanwvxa	284	53	Homologous	Homologous	NNP
cord-282246-wyanwvxa	284	54	2',5'-phosphodiesterases	2',5'-phosphodiesterases	NNP
cord-282246-wyanwvxa	284	55	from	from	IN
cord-282246-wyanwvxa	284	56	disparate	disparate	JJ
cord-282246-wyanwvxa	284	57	RNA	RNA	NNP
cord-282246-wyanwvxa	284	58	viruses	virus	NNS
cord-282246-wyanwvxa	284	59	antagonize	antagonize	VBP
cord-282246-wyanwvxa	284	60	antiviral	antiviral	JJ
cord-282246-wyanwvxa	284	61	innate	innate	JJ
cord-282246-wyanwvxa	284	62	immunity	immunity	NN
cord-282246-wyanwvxa	284	63	Rotavirus	Rotavirus	NNP
cord-282246-wyanwvxa	284	64	controls	control	NNS
cord-282246-wyanwvxa	284	65	activation	activation	NN
cord-282246-wyanwvxa	284	66	of	of	IN
cord-282246-wyanwvxa	284	67	the	the	DT
cord-282246-wyanwvxa	284	68	2	2	CD
cord-282246-wyanwvxa	284	69	0	0	CD
cord-282246-wyanwvxa	284	70	-5	-5	CD
cord-282246-wyanwvxa	284	71	0	0	CD
cord-282246-wyanwvxa	284	72	-oligoadenylate	-oligoadenylate	HYPH
cord-282246-wyanwvxa	284	73	synthetase	synthetase	NN
cord-282246-wyanwvxa	284	74	/	/	SYM
cord-282246-wyanwvxa	284	75	RNase	rnase	NN
cord-282246-wyanwvxa	284	76	L	L	NNP
cord-282246-wyanwvxa	284	77	pathway	pathway	NN
cord-282246-wyanwvxa	284	78	using	use	VBG
cord-282246-wyanwvxa	284	79	at	at	RB
cord-282246-wyanwvxa	284	80	least	least	JJS
cord-282246-wyanwvxa	284	81	two	two	CD
cord-282246-wyanwvxa	284	82	distinct	distinct	JJ
cord-282246-wyanwvxa	284	83	mechanisms	mechanism	NNS
cord-282246-wyanwvxa	284	84	Plotkin	Plotkin	NNP
cord-282246-wyanwvxa	284	85	's	's	POS
cord-282246-wyanwvxa	284	86	vaccines	vaccine	NNS
cord-282246-wyanwvxa	284	87	Status	status	NN
cord-282246-wyanwvxa	284	88	of	of	IN
cord-282246-wyanwvxa	284	89	vaccine	vaccine	NN
cord-282246-wyanwvxa	284	90	research	research	NN
cord-282246-wyanwvxa	284	91	and	and	CC
cord-282246-wyanwvxa	284	92	development	development	NN
cord-282246-wyanwvxa	284	93	for	for	IN
cord-282246-wyanwvxa	284	94	norovirus	norovirus	NN
cord-282246-wyanwvxa	285	1	Does	do	VBZ
cord-282246-wyanwvxa	285	2	a	a	DT
cord-282246-wyanwvxa	285	3	monovalent	monovalent	NN
cord-282246-wyanwvxa	285	4	inactivated	inactivate	VBN
cord-282246-wyanwvxa	285	5	human	human	JJ
cord-282246-wyanwvxa	285	6	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	285	7	vaccine	vaccine	NN
cord-282246-wyanwvxa	285	8	induce	induce	VB
cord-282246-wyanwvxa	285	9	heterotypic	heterotypic	JJ
cord-282246-wyanwvxa	285	10	immunity	immunity	NN
cord-282246-wyanwvxa	285	11	?	?	.
cord-282246-wyanwvxa	286	1	Evidence	evidence	NN
cord-282246-wyanwvxa	286	2	from	from	IN
cord-282246-wyanwvxa	286	3	animal	animal	NN
cord-282246-wyanwvxa	286	4	studies	study	NNS
cord-282246-wyanwvxa	287	1	VP4-and	VP4-and	NNP
cord-282246-wyanwvxa	288	1	VP7-specific	VP7-specific	NNP
cord-282246-wyanwvxa	288	2	antibodies	antibody	NNS
cord-282246-wyanwvxa	288	3	mediate	mediate	VBP
cord-282246-wyanwvxa	288	4	heterotypic	heterotypic	JJ
cord-282246-wyanwvxa	288	5	immunity	immunity	NN
cord-282246-wyanwvxa	288	6	to	to	TO
cord-282246-wyanwvxa	288	7	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	288	8	in	in	IN
cord-282246-wyanwvxa	288	9	humans	human	NNS
cord-282246-wyanwvxa	288	10	Safety	Safety	NNP
cord-282246-wyanwvxa	288	11	and	and	CC
cord-282246-wyanwvxa	288	12	immunogenicity	immunogenicity	NN
cord-282246-wyanwvxa	288	13	of	of	IN
cord-282246-wyanwvxa	288	14	a	a	DT
cord-282246-wyanwvxa	288	15	parenterally	parenterally	NN
cord-282246-wyanwvxa	288	16	administered	administer	VBN
cord-282246-wyanwvxa	288	17	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	288	18	VP8	VP8	NNP
cord-282246-wyanwvxa	288	19	subunit	subunit	NN
cord-282246-wyanwvxa	288	20	vaccine	vaccine	NN
cord-282246-wyanwvxa	288	21	in	in	IN
cord-282246-wyanwvxa	288	22	healthy	healthy	JJ
cord-282246-wyanwvxa	288	23	adults	adult	NNS
cord-282246-wyanwvxa	288	24	Efficacy	Efficacy	NNP
cord-282246-wyanwvxa	288	25	of	of	IN
cord-282246-wyanwvxa	288	26	human	human	JJ
cord-282246-wyanwvxa	288	27	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	288	28	vaccine	vaccine	NN
cord-282246-wyanwvxa	288	29	against	against	IN
cord-282246-wyanwvxa	288	30	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	288	31	gastroenteritis	gastroenteritis	NN
cord-282246-wyanwvxa	288	32	during	during	IN
cord-282246-wyanwvxa	288	33	the	the	DT
cord-282246-wyanwvxa	288	34	first	first	JJ
cord-282246-wyanwvxa	288	35	2	2	CD
cord-282246-wyanwvxa	288	36	years	year	NNS
cord-282246-wyanwvxa	288	37	of	of	IN
cord-282246-wyanwvxa	288	38	life	life	NN
cord-282246-wyanwvxa	288	39	in	in	IN
cord-282246-wyanwvxa	288	40	European	european	JJ
cord-282246-wyanwvxa	288	41	infants	infant	NNS
cord-282246-wyanwvxa	288	42	:	:	:
cord-282246-wyanwvxa	288	43	randomised	randomised	JJ
cord-282246-wyanwvxa	288	44	,	,	,
cord-282246-wyanwvxa	288	45	double	double	JJ
cord-282246-wyanwvxa	288	46	-	-	HYPH
cord-282246-wyanwvxa	288	47	blind	blind	JJ
cord-282246-wyanwvxa	288	48	controlled	control	VBN
cord-282246-wyanwvxa	288	49	study	study	NN
cord-282246-wyanwvxa	288	50	Rotavirus	rotavirus	NN
cord-282246-wyanwvxa	288	51	vaccines	vaccine	NNS
cord-282246-wyanwvxa	288	52	-a	-a	.
cord-282246-wyanwvxa	289	1	new	new	JJ
cord-282246-wyanwvxa	289	2	hope	hope	NN
cord-282246-wyanwvxa	289	3	Jennerian	Jennerian	NNP
cord-282246-wyanwvxa	289	4	and	and	CC
cord-282246-wyanwvxa	289	5	modified	modify	VBD
cord-282246-wyanwvxa	289	6	Jennerian	Jennerian	NNP
cord-282246-wyanwvxa	289	7	approach	approach	NN
cord-282246-wyanwvxa	289	8	to	to	IN
cord-282246-wyanwvxa	289	9	vaccination	vaccination	NN
cord-282246-wyanwvxa	289	10	against	against	IN
cord-282246-wyanwvxa	289	11	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	289	12	diarrhea	diarrhea	NN
cord-282246-wyanwvxa	289	13	using	use	VBG
cord-282246-wyanwvxa	289	14	a	a	DT
cord-282246-wyanwvxa	289	15	quadrivalent	quadrivalent	NN
cord-282246-wyanwvxa	289	16	rhesus	rhesus	NN
cord-282246-wyanwvxa	289	17	rotavirus	rotavirus	NN
cord-282246-wyanwvxa	289	18	(	(	-LRB-
cord-282246-wyanwvxa	289	19	RRV	RRV	NNP
cord-282246-wyanwvxa	289	20	)	)	-RRB-
cord-282246-wyanwvxa	289	21	and	and	CC
cord-282246-wyanwvxa	289	22	human	human	JJ
cord-282246-wyanwvxa	289	23	-	-	HYPH
cord-282246-wyanwvxa	289	24	RRV	rrv	JJ
cord-282246-wyanwvxa	289	25	reassortant	reassortant	JJ
cord-282246-wyanwvxa	289	26	vaccine	vaccine	NN
cord-282246-wyanwvxa	289	27	Safety	safety	NN
cord-282246-wyanwvxa	289	28	and	and	CC
cord-282246-wyanwvxa	289	29	efficacy	efficacy	NN
cord-282246-wyanwvxa	289	30	of	of	IN
cord-282246-wyanwvxa	289	31	a	a	DT
cord-282246-wyanwvxa	289	32	pentavalent	pentavalent	JJ
cord-282246-wyanwvxa	289	33	human	human	JJ
cord-282246-wyanwvxa	289	34	-	-	HYPH
cord-282246-wyanwvxa	289	35	bovine	bovine	JJ
cord-282246-wyanwvxa	289	36	(	(	-LRB-
cord-282246-wyanwvxa	289	37	WC3	wc3	NN
cord-282246-wyanwvxa	289	38	)	)	-RRB-
cord-282246-wyanwvxa	289	39	reassortant	reassortant	JJ
cord-282246-wyanwvxa	289	40	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	289	41	vaccine	vaccine	NN
cord-282246-wyanwvxa	289	42	Efficacy	Efficacy	NNP
cord-282246-wyanwvxa	289	43	of	of	IN
cord-282246-wyanwvxa	289	44	a	a	DT
cord-282246-wyanwvxa	289	45	monovalent	monovalent	NN
cord-282246-wyanwvxa	289	46	humanbovine	humanbovine	NN
cord-282246-wyanwvxa	289	47	(	(	-LRB-
cord-282246-wyanwvxa	289	48	116E	116e	CD
cord-282246-wyanwvxa	289	49	)	)	-RRB-
cord-282246-wyanwvxa	289	50	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	289	51	vaccine	vaccine	NN
cord-282246-wyanwvxa	289	52	in	in	IN
cord-282246-wyanwvxa	289	53	Indian	indian	JJ
cord-282246-wyanwvxa	289	54	infants	infant	NNS
cord-282246-wyanwvxa	289	55	:	:	:
cord-282246-wyanwvxa	289	56	a	a	DT
cord-282246-wyanwvxa	289	57	randomised	randomised	JJ
cord-282246-wyanwvxa	289	58	,	,	,
cord-282246-wyanwvxa	289	59	double	double	JJ
cord-282246-wyanwvxa	289	60	-	-	HYPH
cord-282246-wyanwvxa	289	61	blind	blind	JJ
cord-282246-wyanwvxa	289	62	,	,	,
cord-282246-wyanwvxa	289	63	placebo	placebo	NN
cord-282246-wyanwvxa	289	64	-	-	HYPH
cord-282246-wyanwvxa	289	65	controlled	control	VBN
cord-282246-wyanwvxa	289	66	trial	trial	NN
cord-282246-wyanwvxa	289	67	Effectiveness	Effectiveness	NNP
cord-282246-wyanwvxa	289	68	of	of	IN
cord-282246-wyanwvxa	289	69	the	the	DT
cord-282246-wyanwvxa	289	70	live	live	JJ
cord-282246-wyanwvxa	289	71	attenuated	attenuated	JJ
cord-282246-wyanwvxa	289	72	rotavirus	rotavirus	JJ
cord-282246-wyanwvxa	289	73	vaccine	vaccine	NN
cord-282246-wyanwvxa	289	74	produced	produce	VBN
cord-282246-wyanwvxa	289	75	by	by	IN
cord-282246-wyanwvxa	289	76	a	a	DT
cord-282246-wyanwvxa	289	77	domestic	domestic	JJ
cord-282246-wyanwvxa	289	78	manufacturer	manufacturer	NN
cord-282246-wyanwvxa	289	79	in	in	IN
cord-282246-wyanwvxa	289	80	China	China	NNP
cord-282246-wyanwvxa	289	81	studied	study	VBD
cord-282246-wyanwvxa	289	82	using	use	VBG
cord-282246-wyanwvxa	289	83	a	a	DT
cord-282246-wyanwvxa	289	84	population	population	NN
cord-282246-wyanwvxa	289	85	-	-	HYPH
cord-282246-wyanwvxa	289	86	based	base	VBN
cord-282246-wyanwvxa	289	87	case	case	NN
cord-282246-wyanwvxa	289	88	-	-	HYPH
cord-282246-wyanwvxa	289	89	control	control	NN
cord-282246-wyanwvxa	289	90	design	design	NN