id sid tid token lemma pos cord-280130-ewqe9edq 1 1 key key JJ cord-280130-ewqe9edq 2 1 : : : cord-280130-ewqe9edq 2 2 cord-280130-ewqe9edq cord-280130-ewqe9edq NNS cord-280130-ewqe9edq 2 3 authors author NNS cord-280130-ewqe9edq 2 4 : : : cord-280130-ewqe9edq 2 5 Weber Weber NNP cord-280130-ewqe9edq 2 6 , , , cord-280130-ewqe9edq 2 7 Friedemann Friedemann NNP cord-280130-ewqe9edq 2 8 ; ; : cord-280130-ewqe9edq 2 9 Haller Haller NNP cord-280130-ewqe9edq 2 10 , , , cord-280130-ewqe9edq 2 11 Otto Otto NNP cord-280130-ewqe9edq 2 12 title title NN cord-280130-ewqe9edq 2 13 : : : cord-280130-ewqe9edq 2 14 Viral viral JJ cord-280130-ewqe9edq 2 15 suppression suppression NN cord-280130-ewqe9edq 2 16 of of IN cord-280130-ewqe9edq 2 17 the the DT cord-280130-ewqe9edq 2 18 interferon interferon NN cord-280130-ewqe9edq 2 19 system system NN cord-280130-ewqe9edq 2 20 date date NN cord-280130-ewqe9edq 2 21 : : : cord-280130-ewqe9edq 2 22 2007 2007 CD cord-280130-ewqe9edq 2 23 - - HYPH cord-280130-ewqe9edq 2 24 01 01 CD cord-280130-ewqe9edq 2 25 - - HYPH cord-280130-ewqe9edq 2 26 27 27 CD cord-280130-ewqe9edq 2 27 journal journal NN cord-280130-ewqe9edq 2 28 : : : cord-280130-ewqe9edq 3 1 Biochimie Biochimie NNP cord-280130-ewqe9edq 3 2 DOI DOI NNP cord-280130-ewqe9edq 3 3 : : : cord-280130-ewqe9edq 3 4 10.1016 10.1016 CD cord-280130-ewqe9edq 3 5 / / SYM cord-280130-ewqe9edq 3 6 j.biochi.2007.01.005 j.biochi.2007.01.005 NNP cord-280130-ewqe9edq 3 7 sha sha NNP cord-280130-ewqe9edq 3 8 : : : cord-280130-ewqe9edq 3 9 c6f251b9bf9fc4d89c3f16ae0d62829a18b1b95e c6f251b9bf9fc4d89c3f16ae0d62829a18b1b95e NNP cord-280130-ewqe9edq 3 10 doc_id doc_id NNP cord-280130-ewqe9edq 3 11 : : : cord-280130-ewqe9edq 3 12 280130 280130 CD cord-280130-ewqe9edq 3 13 cord_uid cord_uid NNS cord-280130-ewqe9edq 3 14 : : : cord-280130-ewqe9edq 3 15 ewqe9edq ewqe9edq RB cord-280130-ewqe9edq 4 1 Type type NN cord-280130-ewqe9edq 5 1 I -PRON- PRP cord-280130-ewqe9edq 5 2 interferons interferon NNS cord-280130-ewqe9edq 5 3 ( ( -LRB- cord-280130-ewqe9edq 5 4 IFN IFN NNP cord-280130-ewqe9edq 5 5 - - HYPH cord-280130-ewqe9edq 5 6 α α NNP cord-280130-ewqe9edq 5 7 / / SYM cord-280130-ewqe9edq 5 8 β β NN cord-280130-ewqe9edq 5 9 ) ) -RRB- cord-280130-ewqe9edq 5 10 were be VBD cord-280130-ewqe9edq 5 11 originally originally RB cord-280130-ewqe9edq 5 12 discovered discover VBN cord-280130-ewqe9edq 5 13 by by IN cord-280130-ewqe9edq 5 14 their -PRON- PRP$ cord-280130-ewqe9edq 5 15 strong strong JJ cord-280130-ewqe9edq 5 16 and and CC cord-280130-ewqe9edq 5 17 direct direct JJ cord-280130-ewqe9edq 5 18 antiviral antiviral JJ cord-280130-ewqe9edq 5 19 activity activity NN cord-280130-ewqe9edq 5 20 [ [ -LRB- cord-280130-ewqe9edq 5 21 A. A. NNP cord-280130-ewqe9edq 5 22 Isaacs Isaacs NNP cord-280130-ewqe9edq 5 23 , , , cord-280130-ewqe9edq 5 24 J. J. NNP cord-280130-ewqe9edq 5 25 Lindenmann Lindenmann NNP cord-280130-ewqe9edq 5 26 , , , cord-280130-ewqe9edq 5 27 Virus Virus NNP cord-280130-ewqe9edq 5 28 interference interference NN cord-280130-ewqe9edq 5 29 . . . cord-280130-ewqe9edq 6 1 I. I. NNP cord-280130-ewqe9edq 7 1 The the DT cord-280130-ewqe9edq 7 2 interferon interferon NN cord-280130-ewqe9edq 7 3 , , , cord-280130-ewqe9edq 7 4 Proc proc NN cord-280130-ewqe9edq 7 5 . . . cord-280130-ewqe9edq 8 1 R. R. NNP cord-280130-ewqe9edq 8 2 Soc Soc NNP cord-280130-ewqe9edq 8 3 . . . cord-280130-ewqe9edq 9 1 Lond Lond NNP cord-280130-ewqe9edq 9 2 . . . cord-280130-ewqe9edq 10 1 B B NNP cord-280130-ewqe9edq 10 2 Biol Biol NNP cord-280130-ewqe9edq 10 3 . . . cord-280130-ewqe9edq 11 1 Sci Sci NNP cord-280130-ewqe9edq 11 2 . . NNP cord-280130-ewqe9edq 11 3 147 147 CD cord-280130-ewqe9edq 11 4 ( ( -LRB- cord-280130-ewqe9edq 11 5 1957 1957 CD cord-280130-ewqe9edq 11 6 ) ) -RRB- cord-280130-ewqe9edq 11 7 258–267 258–267 CD cord-280130-ewqe9edq 11 8 ] ] -RRB- cord-280130-ewqe9edq 11 9 . . . cord-280130-ewqe9edq 12 1 ( ( -LRB- cord-280130-ewqe9edq 12 2 see see VB cord-280130-ewqe9edq 12 3 review review NN cord-280130-ewqe9edq 12 4 by by IN cord-280130-ewqe9edq 12 5 J. J. NNP cord-280130-ewqe9edq 12 6 Lindenmann Lindenmann NNP cord-280130-ewqe9edq 12 7 on on IN cord-280130-ewqe9edq 12 8 p. p. NN cord-280130-ewqe9edq 12 9 719 719 CD cord-280130-ewqe9edq 12 10 , , , cord-280130-ewqe9edq 12 11 in in IN cord-280130-ewqe9edq 12 12 this this DT cord-280130-ewqe9edq 12 13 issue issue NN cord-280130-ewqe9edq 12 14 ) ) -RRB- cord-280130-ewqe9edq 12 15 . . . cord-280130-ewqe9edq 13 1 Nevertheless nevertheless RB cord-280130-ewqe9edq 13 2 , , , cord-280130-ewqe9edq 13 3 only only RB cord-280130-ewqe9edq 13 4 very very RB cord-280130-ewqe9edq 13 5 recently recently RB cord-280130-ewqe9edq 13 6 it -PRON- PRP cord-280130-ewqe9edq 13 7 was be VBD cord-280130-ewqe9edq 13 8 entirely entirely RB cord-280130-ewqe9edq 13 9 realized realize VBN cord-280130-ewqe9edq 13 10 that that IN cord-280130-ewqe9edq 13 11 viruses virus NNS cord-280130-ewqe9edq 13 12 would would MD cord-280130-ewqe9edq 13 13 not not RB cord-280130-ewqe9edq 13 14 succeed succeed VB cord-280130-ewqe9edq 13 15 without without IN cord-280130-ewqe9edq 13 16 efficient efficient JJ cord-280130-ewqe9edq 13 17 tools tool NNS cord-280130-ewqe9edq 13 18 to to TO cord-280130-ewqe9edq 13 19 undermine undermine VB cord-280130-ewqe9edq 13 20 this this DT cord-280130-ewqe9edq 13 21 potent potent JJ cord-280130-ewqe9edq 13 22 host host NN cord-280130-ewqe9edq 13 23 defense defense NN cord-280130-ewqe9edq 13 24 system system NN cord-280130-ewqe9edq 13 25 . . . cord-280130-ewqe9edq 14 1 Current current JJ cord-280130-ewqe9edq 14 2 investigations investigation NNS cord-280130-ewqe9edq 14 3 are be VBP cord-280130-ewqe9edq 14 4 revealing reveal VBG cord-280130-ewqe9edq 14 5 an an DT cord-280130-ewqe9edq 14 6 astonishing astonishing JJ cord-280130-ewqe9edq 14 7 variety variety NN cord-280130-ewqe9edq 14 8 of of IN cord-280130-ewqe9edq 14 9 viral viral JJ cord-280130-ewqe9edq 14 10 IFN IFN NNP cord-280130-ewqe9edq 14 11 antagonistic antagonistic JJ cord-280130-ewqe9edq 14 12 strategies strategy NNS cord-280130-ewqe9edq 14 13 targeting target VBG cord-280130-ewqe9edq 14 14 virtually virtually RB cord-280130-ewqe9edq 14 15 all all DT cord-280130-ewqe9edq 14 16 parts part NNS cord-280130-ewqe9edq 14 17 of of IN cord-280130-ewqe9edq 14 18 the the DT cord-280130-ewqe9edq 14 19 IFN IFN NNP cord-280130-ewqe9edq 14 20 system system NN cord-280130-ewqe9edq 14 21 , , , cord-280130-ewqe9edq 14 22 often often RB cord-280130-ewqe9edq 14 23 in in IN cord-280130-ewqe9edq 14 24 a a DT cord-280130-ewqe9edq 14 25 highly highly RB cord-280130-ewqe9edq 14 26 specific specific JJ cord-280130-ewqe9edq 14 27 manner manner NN cord-280130-ewqe9edq 14 28 . . . cord-280130-ewqe9edq 15 1 Viruses virus NNS cord-280130-ewqe9edq 15 2 were be VBD cord-280130-ewqe9edq 15 3 found find VBN cord-280130-ewqe9edq 15 4 to to TO cord-280130-ewqe9edq 15 5 interfere interfere VB cord-280130-ewqe9edq 15 6 with with IN cord-280130-ewqe9edq 15 7 induction induction NN cord-280130-ewqe9edq 15 8 of of IN cord-280130-ewqe9edq 15 9 IFN IFN NNP cord-280130-ewqe9edq 15 10 synthesis synthesis NN cord-280130-ewqe9edq 15 11 , , , cord-280130-ewqe9edq 15 12 IFN IFN NNP cord-280130-ewqe9edq 15 13 - - HYPH cord-280130-ewqe9edq 15 14 induced induce VBN cord-280130-ewqe9edq 15 15 signaling signal VBG cord-280130-ewqe9edq 15 16 events event NNS cord-280130-ewqe9edq 15 17 , , , cord-280130-ewqe9edq 15 18 the the DT cord-280130-ewqe9edq 15 19 antiviral antiviral JJ cord-280130-ewqe9edq 15 20 effector effector NN cord-280130-ewqe9edq 15 21 proteins protein NNS cord-280130-ewqe9edq 15 22 , , , cord-280130-ewqe9edq 15 23 or or CC cord-280130-ewqe9edq 15 24 simply simply RB cord-280130-ewqe9edq 15 25 shut shut VB cord-280130-ewqe9edq 15 26 off off RP cord-280130-ewqe9edq 15 27 the the DT cord-280130-ewqe9edq 15 28 host host NN cord-280130-ewqe9edq 15 29 cell cell NN cord-280130-ewqe9edq 15 30 macromolecule macromolecule NN cord-280130-ewqe9edq 15 31 synthesis synthesis NN cord-280130-ewqe9edq 15 32 machinery machinery NN cord-280130-ewqe9edq 15 33 to to TO cord-280130-ewqe9edq 15 34 avoid avoid VB cord-280130-ewqe9edq 15 35 booting boot VBG cord-280130-ewqe9edq 15 36 of of IN cord-280130-ewqe9edq 15 37 the the DT cord-280130-ewqe9edq 15 38 antiviral antiviral JJ cord-280130-ewqe9edq 15 39 host host NN cord-280130-ewqe9edq 15 40 defense defense NN cord-280130-ewqe9edq 15 41 . . . cord-280130-ewqe9edq 16 1 Here here RB cord-280130-ewqe9edq 16 2 , , , cord-280130-ewqe9edq 16 3 we -PRON- PRP cord-280130-ewqe9edq 16 4 will will MD cord-280130-ewqe9edq 16 5 describe describe VB cord-280130-ewqe9edq 16 6 a a DT cord-280130-ewqe9edq 16 7 few few JJ cord-280130-ewqe9edq 16 8 well well RB cord-280130-ewqe9edq 16 9 - - HYPH cord-280130-ewqe9edq 16 10 characterized characterize VBN cord-280130-ewqe9edq 16 11 examples example NNS cord-280130-ewqe9edq 16 12 to to TO cord-280130-ewqe9edq 16 13 illustrate illustrate VB cord-280130-ewqe9edq 16 14 the the DT cord-280130-ewqe9edq 16 15 sophisticated sophisticated JJ cord-280130-ewqe9edq 16 16 and and CC cord-280130-ewqe9edq 16 17 often often RB cord-280130-ewqe9edq 16 18 multi multi JJ cord-280130-ewqe9edq 16 19 - - JJ cord-280130-ewqe9edq 16 20 layered layered JJ cord-280130-ewqe9edq 16 21 anti anti JJ cord-280130-ewqe9edq 16 22 - - JJ cord-280130-ewqe9edq 16 23 IFN IFN NNP cord-280130-ewqe9edq 16 24 mechanisms mechanism NNS cord-280130-ewqe9edq 16 25 employed employ VBN cord-280130-ewqe9edq 16 26 by by IN cord-280130-ewqe9edq 16 27 viruses virus NNS cord-280130-ewqe9edq 16 28 . . . cord-280130-ewqe9edq 17 1 In in IN cord-280130-ewqe9edq 17 2 most most RBS cord-280130-ewqe9edq 17 3 nucleated nucleated JJ cord-280130-ewqe9edq 17 4 body body NN cord-280130-ewqe9edq 17 5 cells cell NNS cord-280130-ewqe9edq 17 6 , , , cord-280130-ewqe9edq 17 7 viral viral JJ cord-280130-ewqe9edq 17 8 infections infection NNS cord-280130-ewqe9edq 17 9 activate activate VBP cord-280130-ewqe9edq 17 10 transcription transcription NN cord-280130-ewqe9edq 17 11 of of IN cord-280130-ewqe9edq 17 12 the the DT cord-280130-ewqe9edq 17 13 ' ' `` cord-280130-ewqe9edq 17 14 ' ' `` cord-280130-ewqe9edq 17 15 classic classic JJ cord-280130-ewqe9edq 17 16 ' ' '' cord-280130-ewqe9edq 17 17 ' ' '' cord-280130-ewqe9edq 17 18 IFN IFN NNP cord-280130-ewqe9edq 17 19 - - HYPH cord-280130-ewqe9edq 17 20 b b NN cord-280130-ewqe9edq 17 21 gene gene NN cord-280130-ewqe9edq 17 22 [ [ -LRB- cord-280130-ewqe9edq 17 23 1 1 CD cord-280130-ewqe9edq 17 24 ] ] -RRB- cord-280130-ewqe9edq 17 25 by by IN cord-280130-ewqe9edq 17 26 a a DT cord-280130-ewqe9edq 17 27 signaling signal VBG cord-280130-ewqe9edq 17 28 chain chain NN cord-280130-ewqe9edq 17 29 which which WDT cord-280130-ewqe9edq 17 30 is be VBZ cord-280130-ewqe9edq 17 31 initiated initiate VBN cord-280130-ewqe9edq 17 32 by by IN cord-280130-ewqe9edq 17 33 the the DT cord-280130-ewqe9edq 17 34 RNA RNA NNP cord-280130-ewqe9edq 17 35 sensors sensor NNS cord-280130-ewqe9edq 17 36 RIG rig NN cord-280130-ewqe9edq 17 37 - - : cord-280130-ewqe9edq 17 38 I I NNP cord-280130-ewqe9edq 17 39 and and CC cord-280130-ewqe9edq 17 40 MDA-5 MDA-5 NNP cord-280130-ewqe9edq 17 41 , , , cord-280130-ewqe9edq 17 42 which which WDT cord-280130-ewqe9edq 17 43 in in IN cord-280130-ewqe9edq 17 44 turn turn NN cord-280130-ewqe9edq 17 45 act act RB cord-280130-ewqe9edq 17 46 trough trough IN cord-280130-ewqe9edq 17 47 the the DT cord-280130-ewqe9edq 17 48 adaptor adaptor NN cord-280130-ewqe9edq 17 49 IPS-1 IPS-1 NNP cord-280130-ewqe9edq 17 50 and and CC cord-280130-ewqe9edq 17 51 the the DT cord-280130-ewqe9edq 17 52 kinases kinase NNS cord-280130-ewqe9edq 17 53 TBK-1 TBK-1 NNP cord-280130-ewqe9edq 17 54 and and CC cord-280130-ewqe9edq 17 55 IKK-3 IKK-3 NNP cord-280130-ewqe9edq 17 56 to to TO cord-280130-ewqe9edq 17 57 activate activate VB cord-280130-ewqe9edq 17 58 the the DT cord-280130-ewqe9edq 17 59 transcription transcription NN cord-280130-ewqe9edq 17 60 factor factor NN cord-280130-ewqe9edq 17 61 IRF-3 IRF-3 NNP cord-280130-ewqe9edq 18 1 ( ( -LRB- cord-280130-ewqe9edq 18 2 see see VB cord-280130-ewqe9edq 18 3 reviews review NNS cord-280130-ewqe9edq 18 4 by by IN cord-280130-ewqe9edq 18 5 P. P. NNP cord-280130-ewqe9edq 18 6 Pitha Pitha NNP cord-280130-ewqe9edq 18 7 and and CC cord-280130-ewqe9edq 18 8 by by IN cord-280130-ewqe9edq 18 9 T. T. NNP cord-280130-ewqe9edq 18 10 Fujita Fujita NNP cord-280130-ewqe9edq 18 11 on on IN cord-280130-ewqe9edq 18 12 pages page NNS cord-280130-ewqe9edq 18 13 744 744 CD cord-280130-ewqe9edq 18 14 and and CC cord-280130-ewqe9edq 18 15 754 754 CD cord-280130-ewqe9edq 18 16 this this DT cord-280130-ewqe9edq 18 17 issue issue NN cord-280130-ewqe9edq 18 18 respectively respectively RB cord-280130-ewqe9edq 18 19 ) ) -RRB- cord-280130-ewqe9edq 18 20 . . . cord-280130-ewqe9edq 19 1 A a DT cord-280130-ewqe9edq 19 2 parallel parallel JJ cord-280130-ewqe9edq 19 3 pathway pathway NN cord-280130-ewqe9edq 19 4 involves involve VBZ cord-280130-ewqe9edq 19 5 the the DT cord-280130-ewqe9edq 19 6 dsRNA dsrna RB cord-280130-ewqe9edq 19 7 - - HYPH cord-280130-ewqe9edq 19 8 binding bind VBG cord-280130-ewqe9edq 19 9 kinase kinase NN cord-280130-ewqe9edq 19 10 PKR PKR NNP cord-280130-ewqe9edq 19 11 , , , cord-280130-ewqe9edq 19 12 the the DT cord-280130-ewqe9edq 19 13 TRAF TRAF NNP cord-280130-ewqe9edq 19 14 adaptor adaptor NN cord-280130-ewqe9edq 19 15 molecules molecule NNS cord-280130-ewqe9edq 19 16 and and CC cord-280130-ewqe9edq 19 17 the the DT cord-280130-ewqe9edq 19 18 NF NF NNP cord-280130-ewqe9edq 19 19 - - HYPH cord-280130-ewqe9edq 19 20 kB kB NNP cord-280130-ewqe9edq 19 21 kinase kinase NNP cord-280130-ewqe9edq 19 22 IKKa IKKa NNP cord-280130-ewqe9edq 19 23 / / SYM cord-280130-ewqe9edq 19 24 b b LS cord-280130-ewqe9edq 19 25 ( ( -LRB- cord-280130-ewqe9edq 19 26 see see VB cord-280130-ewqe9edq 19 27 review review NN cord-280130-ewqe9edq 19 28 by by IN cord-280130-ewqe9edq 19 29 García García NNP cord-280130-ewqe9edq 19 30 et et NNP cord-280130-ewqe9edq 19 31 al al NNP cord-280130-ewqe9edq 19 32 . . NNP cord-280130-ewqe9edq 19 33 , , , cord-280130-ewqe9edq 19 34 on on IN cord-280130-ewqe9edq 19 35 p. p. NN cord-280130-ewqe9edq 19 36 799 799 CD cord-280130-ewqe9edq 19 37 this this DT cord-280130-ewqe9edq 19 38 issue issue NN cord-280130-ewqe9edq 19 39 ) ) -RRB- cord-280130-ewqe9edq 19 40 . . . cord-280130-ewqe9edq 20 1 Most Most JJS cord-280130-ewqe9edq 20 2 viruses virus NNS cord-280130-ewqe9edq 20 3 investigated investigate VBN cord-280130-ewqe9edq 20 4 so so RB cord-280130-ewqe9edq 20 5 far far RB cord-280130-ewqe9edq 20 6 interfere interfere VBP cord-280130-ewqe9edq 20 7 with with IN cord-280130-ewqe9edq 20 8 one one CD cord-280130-ewqe9edq 20 9 or or CC cord-280130-ewqe9edq 20 10 several several JJ cord-280130-ewqe9edq 20 11 steps step NNS cord-280130-ewqe9edq 20 12 in in IN cord-280130-ewqe9edq 20 13 these these DT cord-280130-ewqe9edq 20 14 important important JJ cord-280130-ewqe9edq 20 15 signaling signal VBG cord-280130-ewqe9edq 20 16 chains chain NNS cord-280130-ewqe9edq 20 17 [ [ -LRB- cord-280130-ewqe9edq 20 18 2e6 2e6 CD cord-280130-ewqe9edq 20 19 ] ] -RRB- cord-280130-ewqe9edq 20 20 . . . cord-280130-ewqe9edq 21 1 Fig Fig NNP cord-280130-ewqe9edq 21 2 . . NNP cord-280130-ewqe9edq 21 3 1 1 CD cord-280130-ewqe9edq 21 4 provides provide VBZ cord-280130-ewqe9edq 21 5 a a DT cord-280130-ewqe9edq 21 6 schematic schematic JJ cord-280130-ewqe9edq 21 7 overview overview NN cord-280130-ewqe9edq 21 8 over over IN cord-280130-ewqe9edq 21 9 the the DT cord-280130-ewqe9edq 21 10 IFN IFN NNP cord-280130-ewqe9edq 21 11 induction induction NN cord-280130-ewqe9edq 21 12 pathway pathway NN cord-280130-ewqe9edq 21 13 and and CC cord-280130-ewqe9edq 21 14 some some DT cord-280130-ewqe9edq 21 15 selected select VBN cord-280130-ewqe9edq 21 16 viral viral JJ cord-280130-ewqe9edq 21 17 counterparts counterpart NNS cord-280130-ewqe9edq 21 18 . . . cord-280130-ewqe9edq 22 1 Until until IN cord-280130-ewqe9edq 22 2 very very RB cord-280130-ewqe9edq 22 3 recently recently RB cord-280130-ewqe9edq 22 4 , , , cord-280130-ewqe9edq 22 5 it -PRON- PRP cord-280130-ewqe9edq 22 6 was be VBD cord-280130-ewqe9edq 22 7 thought think VBN cord-280130-ewqe9edq 22 8 that that IN cord-280130-ewqe9edq 22 9 the the DT cord-280130-ewqe9edq 22 10 only only JJ cord-280130-ewqe9edq 22 11 IFN IFN NNP cord-280130-ewqe9edq 22 12 - - HYPH cord-280130-ewqe9edq 22 13 inducing induce VBG cord-280130-ewqe9edq 22 14 molecule molecule NN cord-280130-ewqe9edq 22 15 which which WDT cord-280130-ewqe9edq 22 16 clearly clearly RB cord-280130-ewqe9edq 22 17 distinguishes distinguish VBZ cord-280130-ewqe9edq 22 18 viruses virus NNS cord-280130-ewqe9edq 22 19 from from IN cord-280130-ewqe9edq 22 20 their -PRON- PRP$ cord-280130-ewqe9edq 22 21 host host NN cord-280130-ewqe9edq 22 22 ( ( -LRB- cord-280130-ewqe9edq 22 23 i.e. i.e. FW cord-280130-ewqe9edq 22 24 self self NN cord-280130-ewqe9edq 22 25 vs. vs. FW cord-280130-ewqe9edq 22 26 non non JJ cord-280130-ewqe9edq 22 27 - - JJ cord-280130-ewqe9edq 22 28 self self JJ cord-280130-ewqe9edq 22 29 ) ) -RRB- cord-280130-ewqe9edq 22 30 is be VBZ cord-280130-ewqe9edq 22 31 double double RB cord-280130-ewqe9edq 22 32 - - HYPH cord-280130-ewqe9edq 22 33 stranded strand VBN cord-280130-ewqe9edq 22 34 RNA RNA NNP cord-280130-ewqe9edq 22 35 ( ( -LRB- cord-280130-ewqe9edq 22 36 dsRNA dsrna NN cord-280130-ewqe9edq 22 37 ) ) -RRB- cord-280130-ewqe9edq 22 38 . . . cord-280130-ewqe9edq 23 1 Many many JJ cord-280130-ewqe9edq 23 2 RNA RNA NNP cord-280130-ewqe9edq 23 3 and and CC cord-280130-ewqe9edq 23 4 DNA dna NN cord-280130-ewqe9edq 23 5 viruses virus NNS cord-280130-ewqe9edq 23 6 therefore therefore RB cord-280130-ewqe9edq 23 7 express express VBP cord-280130-ewqe9edq 23 8 proteins protein NNS cord-280130-ewqe9edq 23 9 which which WDT cord-280130-ewqe9edq 23 10 bind bind VBP cord-280130-ewqe9edq 23 11 this this DT cord-280130-ewqe9edq 23 12 key key JJ cord-280130-ewqe9edq 23 13 molecule molecule NN cord-280130-ewqe9edq 23 14 to to TO cord-280130-ewqe9edq 23 15 avoid avoid VB cord-280130-ewqe9edq 23 16 both both CC cord-280130-ewqe9edq 23 17 IFN IFN NNP cord-280130-ewqe9edq 23 18 induction induction NN cord-280130-ewqe9edq 23 19 and and CC cord-280130-ewqe9edq 23 20 activation activation NN cord-280130-ewqe9edq 23 21 of of IN cord-280130-ewqe9edq 23 22 dsRNA dsrna JJ cord-280130-ewqe9edq 23 23 - - HYPH cord-280130-ewqe9edq 23 24 dependent dependent JJ cord-280130-ewqe9edq 23 25 antiviral antiviral JJ cord-280130-ewqe9edq 23 26 enzymes enzyme NNS cord-280130-ewqe9edq 23 27 [ [ -LRB- cord-280130-ewqe9edq 23 28 7 7 CD cord-280130-ewqe9edq 23 29 , , , cord-280130-ewqe9edq 23 30 8 8 CD cord-280130-ewqe9edq 23 31 ] ] -RRB- cord-280130-ewqe9edq 23 32 . . . cord-280130-ewqe9edq 24 1 Well well RB cord-280130-ewqe9edq 24 2 - - HYPH cord-280130-ewqe9edq 24 3 investigated investigate VBN cord-280130-ewqe9edq 24 4 examples example NNS cord-280130-ewqe9edq 24 5 are be VBP cord-280130-ewqe9edq 24 6 the the DT cord-280130-ewqe9edq 24 7 NS1 ns1 NN cord-280130-ewqe9edq 24 8 protein protein NN cord-280130-ewqe9edq 24 9 of of IN cord-280130-ewqe9edq 24 10 influenza influenza NN cord-280130-ewqe9edq 24 11 A a DT cord-280130-ewqe9edq 24 12 virus virus NN cord-280130-ewqe9edq 24 13 [ [ -LRB- cord-280130-ewqe9edq 24 14 9e12 9e12 CD cord-280130-ewqe9edq 24 15 ] ] -RRB- cord-280130-ewqe9edq 24 16 , , , cord-280130-ewqe9edq 24 17 the the DT cord-280130-ewqe9edq 24 18 E3L e3l NN cord-280130-ewqe9edq 24 19 protein protein NN cord-280130-ewqe9edq 24 20 of of IN cord-280130-ewqe9edq 24 21 poxviruses poxvirus NNS cord-280130-ewqe9edq 24 22 [ [ -LRB- cord-280130-ewqe9edq 24 23 13 13 CD cord-280130-ewqe9edq 24 24 , , , cord-280130-ewqe9edq 24 25 14 14 CD cord-280130-ewqe9edq 24 26 ] ] -RRB- cord-280130-ewqe9edq 24 27 , , , cord-280130-ewqe9edq 24 28 the the DT cord-280130-ewqe9edq 24 29 VP35 VP35 NNP cord-280130-ewqe9edq 24 30 protein protein NN cord-280130-ewqe9edq 24 31 of of IN cord-280130-ewqe9edq 24 32 Ebola Ebola NNP cord-280130-ewqe9edq 24 33 virus virus NN cord-280130-ewqe9edq 24 34 [ [ -LRB- cord-280130-ewqe9edq 24 35 15 15 CD cord-280130-ewqe9edq 24 36 , , , cord-280130-ewqe9edq 24 37 16 16 CD cord-280130-ewqe9edq 24 38 ] ] -RRB- cord-280130-ewqe9edq 24 39 , , , cord-280130-ewqe9edq 24 40 the the DT cord-280130-ewqe9edq 24 41 sigma3 sigma3 NN cord-280130-ewqe9edq 24 42 protein protein NN cord-280130-ewqe9edq 24 43 of of IN cord-280130-ewqe9edq 24 44 reoviruses reovirus NNS cord-280130-ewqe9edq 24 45 [ [ -LRB- cord-280130-ewqe9edq 24 46 17 17 CD cord-280130-ewqe9edq 24 47 ] ] -RRB- cord-280130-ewqe9edq 24 48 , , , cord-280130-ewqe9edq 24 49 and and CC cord-280130-ewqe9edq 24 50 the the DT cord-280130-ewqe9edq 24 51 US11 US11 NNP cord-280130-ewqe9edq 24 52 protein protein NN cord-280130-ewqe9edq 24 53 of of IN cord-280130-ewqe9edq 24 54 herpes herpes NNP cord-280130-ewqe9edq 24 55 simplex simplex NNP cord-280130-ewqe9edq 24 56 virus virus NN cord-280130-ewqe9edq 24 57 [ [ -LRB- cord-280130-ewqe9edq 24 58 18 18 CD cord-280130-ewqe9edq 24 59 , , , cord-280130-ewqe9edq 24 60 19 19 CD cord-280130-ewqe9edq 24 61 ] ] -RRB- cord-280130-ewqe9edq 24 62 . . . cord-280130-ewqe9edq 25 1 The the DT cord-280130-ewqe9edq 25 2 murine murine JJ cord-280130-ewqe9edq 25 3 cytomegalovirus cytomegalovirus NN cord-280130-ewqe9edq 25 4 encodes encode VBZ cord-280130-ewqe9edq 25 5 two two CD cord-280130-ewqe9edq 25 6 proteins protein NNS cord-280130-ewqe9edq 25 7 , , , cord-280130-ewqe9edq 25 8 m142 m142 NN cord-280130-ewqe9edq 25 9 and and CC cord-280130-ewqe9edq 25 10 m143 m143 NN cord-280130-ewqe9edq 25 11 which which WDT cord-280130-ewqe9edq 25 12 together together RB cord-280130-ewqe9edq 25 13 block block VBP cord-280130-ewqe9edq 25 14 dsRNA dsrna RB cord-280130-ewqe9edq 25 15 - - HYPH cord-280130-ewqe9edq 25 16 mediated mediate VBN cord-280130-ewqe9edq 25 17 signaling signal VBG cord-280130-ewqe9edq 25 18 pathways pathway NNS cord-280130-ewqe9edq 25 19 [ [ -LRB- cord-280130-ewqe9edq 25 20 20 20 CD cord-280130-ewqe9edq 25 21 , , , cord-280130-ewqe9edq 25 22 21 21 CD cord-280130-ewqe9edq 25 23 ] ] -RRB- cord-280130-ewqe9edq 25 24 . . . cord-280130-ewqe9edq 26 1 However however RB cord-280130-ewqe9edq 26 2 , , , cord-280130-ewqe9edq 26 3 in in IN cord-280130-ewqe9edq 26 4 the the DT cord-280130-ewqe9edq 26 5 case case NN cord-280130-ewqe9edq 26 6 of of IN cord-280130-ewqe9edq 26 7 the the DT cord-280130-ewqe9edq 26 8 influenza influenza NN cord-280130-ewqe9edq 26 9 virus virus NN cord-280130-ewqe9edq 26 10 NS1 ns1 NN cord-280130-ewqe9edq 26 11 and and CC cord-280130-ewqe9edq 26 12 the the DT cord-280130-ewqe9edq 26 13 Ebola Ebola NNP cord-280130-ewqe9edq 26 14 virus virus NN cord-280130-ewqe9edq 26 15 VP35 VP35 NNP cord-280130-ewqe9edq 26 16 dsRNA dsrna RB cord-280130-ewqe9edq 26 17 - - HYPH cord-280130-ewqe9edq 26 18 binding bind VBG cord-280130-ewqe9edq 26 19 appears appear VBZ cord-280130-ewqe9edq 26 20 only only RB cord-280130-ewqe9edq 26 21 to to TO cord-280130-ewqe9edq 26 22 contribute contribute VB cord-280130-ewqe9edq 26 23 to to IN cord-280130-ewqe9edq 26 24 the the DT cord-280130-ewqe9edq 26 25 IFN IFN NNP cord-280130-ewqe9edq 26 26 antagonism antagonism NN cord-280130-ewqe9edq 26 27 without without IN cord-280130-ewqe9edq 26 28 being be VBG cord-280130-ewqe9edq 26 29 essential essential JJ cord-280130-ewqe9edq 26 30 [ [ -LRB- cord-280130-ewqe9edq 26 31 15 15 CD cord-280130-ewqe9edq 26 32 , , , cord-280130-ewqe9edq 26 33 22 22 CD cord-280130-ewqe9edq 26 34 , , , cord-280130-ewqe9edq 26 35 23 23 CD cord-280130-ewqe9edq 26 36 ] ] -RRB- cord-280130-ewqe9edq 26 37 . . . cord-280130-ewqe9edq 27 1 In in IN cord-280130-ewqe9edq 27 2 addition addition NN cord-280130-ewqe9edq 27 3 , , , cord-280130-ewqe9edq 27 4 we -PRON- PRP cord-280130-ewqe9edq 27 5 have have VBP cord-280130-ewqe9edq 27 6 recently recently RB cord-280130-ewqe9edq 27 7 shown show VBN cord-280130-ewqe9edq 27 8 that that IN cord-280130-ewqe9edq 27 9 some some DT cord-280130-ewqe9edq 27 10 viruses virus NNS cord-280130-ewqe9edq 27 11 do do VBP cord-280130-ewqe9edq 27 12 not not RB cord-280130-ewqe9edq 27 13 produce produce VB cord-280130-ewqe9edq 27 14 detectable detectable JJ cord-280130-ewqe9edq 27 15 amounts amount NNS cord-280130-ewqe9edq 27 16 of of IN cord-280130-ewqe9edq 27 17 dsRNA dsrna NN cord-280130-ewqe9edq 27 18 at at RB cord-280130-ewqe9edq 27 19 all all RB cord-280130-ewqe9edq 27 20 [ [ -LRB- cord-280130-ewqe9edq 27 21 24 24 CD cord-280130-ewqe9edq 27 22 ] ] -RRB- cord-280130-ewqe9edq 27 23 , , , cord-280130-ewqe9edq 27 24 indicating indicate VBG cord-280130-ewqe9edq 27 25 that that IN cord-280130-ewqe9edq 27 26 in in IN cord-280130-ewqe9edq 27 27 these these DT cord-280130-ewqe9edq 27 28 cases case NNS cord-280130-ewqe9edq 27 29 other other JJ cord-280130-ewqe9edq 27 30 molecules molecule NNS cord-280130-ewqe9edq 27 31 IFN IFN NNP cord-280130-ewqe9edq 27 32 - - HYPH cord-280130-ewqe9edq 27 33 eliciting elicit VBG cord-280130-ewqe9edq 27 34 molecules molecule NNS cord-280130-ewqe9edq 27 35 are be VBP cord-280130-ewqe9edq 27 36 important important JJ cord-280130-ewqe9edq 27 37 . . . cord-280130-ewqe9edq 28 1 Indeed indeed RB cord-280130-ewqe9edq 28 2 , , , cord-280130-ewqe9edq 28 3 viral viral JJ cord-280130-ewqe9edq 28 4 ssRNAs ssRNAs NNP cord-280130-ewqe9edq 28 5 bearing bear VBG cord-280130-ewqe9edq 28 6 a a DT cord-280130-ewqe9edq 28 7 5 5 CD cord-280130-ewqe9edq 28 8 0 0 CD cord-280130-ewqe9edq 28 9 triphosphate triphosphate NN cord-280130-ewqe9edq 28 10 group group NN cord-280130-ewqe9edq 28 11 are be VBP cord-280130-ewqe9edq 28 12 a a DT cord-280130-ewqe9edq 28 13 potent potent JJ cord-280130-ewqe9edq 28 14 trigger trigger NN cord-280130-ewqe9edq 28 15 of of IN cord-280130-ewqe9edq 28 16 IFN IFN NNP cord-280130-ewqe9edq 28 17 induction induction NN cord-280130-ewqe9edq 28 18 , , , cord-280130-ewqe9edq 28 19 acting act VBG cord-280130-ewqe9edq 28 20 through through IN cord-280130-ewqe9edq 28 21 RIG rig NN cord-280130-ewqe9edq 28 22 - - : cord-280130-ewqe9edq 28 23 I i NN cord-280130-ewqe9edq 28 24 [ [ -LRB- cord-280130-ewqe9edq 28 25 25 25 CD cord-280130-ewqe9edq 28 26 , , , cord-280130-ewqe9edq 28 27 26 26 CD cord-280130-ewqe9edq 28 28 ] ] -RRB- cord-280130-ewqe9edq 28 29 . . . cord-280130-ewqe9edq 29 1 In in IN cord-280130-ewqe9edq 29 2 line line NN cord-280130-ewqe9edq 29 3 with with IN cord-280130-ewqe9edq 29 4 this this DT cord-280130-ewqe9edq 29 5 , , , cord-280130-ewqe9edq 29 6 it -PRON- PRP cord-280130-ewqe9edq 29 7 was be VBD cord-280130-ewqe9edq 29 8 shown show VBN cord-280130-ewqe9edq 29 9 that that IN cord-280130-ewqe9edq 29 10 the the DT cord-280130-ewqe9edq 29 11 NS1 ns1 NN cord-280130-ewqe9edq 29 12 of of IN cord-280130-ewqe9edq 29 13 influenza influenza NN cord-280130-ewqe9edq 29 14 A a DT cord-280130-ewqe9edq 29 15 virus virus NN cord-280130-ewqe9edq 29 16 can can MD cord-280130-ewqe9edq 29 17 bind bind VB cord-280130-ewqe9edq 29 18 ssRNA ssRNA `` cord-280130-ewqe9edq 29 19 as as RB cord-280130-ewqe9edq 29 20 well well RB cord-280130-ewqe9edq 29 21 , , , cord-280130-ewqe9edq 29 22 and and CC cord-280130-ewqe9edq 29 23 is be VBZ cord-280130-ewqe9edq 29 24 able able JJ cord-280130-ewqe9edq 29 25 to to TO cord-280130-ewqe9edq 29 26 form form VB cord-280130-ewqe9edq 29 27 complexes complex NNS cord-280130-ewqe9edq 29 28 with with IN cord-280130-ewqe9edq 29 29 RIG rig NN cord-280130-ewqe9edq 29 30 - - : cord-280130-ewqe9edq 29 31 I i NN cord-280130-ewqe9edq 29 32 [ [ -LRB- cord-280130-ewqe9edq 29 33 26 26 CD cord-280130-ewqe9edq 29 34 , , , cord-280130-ewqe9edq 29 35 27 27 CD cord-280130-ewqe9edq 29 36 ] ] -RRB- cord-280130-ewqe9edq 29 37 . . . cord-280130-ewqe9edq 30 1 Similarly similarly RB cord-280130-ewqe9edq 30 2 , , , cord-280130-ewqe9edq 30 3 a a DT cord-280130-ewqe9edq 30 4 dsRNA dsrna RB cord-280130-ewqe9edq 30 5 - - HYPH cord-280130-ewqe9edq 30 6 binding bind VBG cord-280130-ewqe9edq 30 7 defective defective JJ cord-280130-ewqe9edq 30 8 VP35 VP35 NNP cord-280130-ewqe9edq 30 9 mutant mutant NN cord-280130-ewqe9edq 30 10 can can MD cord-280130-ewqe9edq 30 11 still still RB cord-280130-ewqe9edq 30 12 block block VB cord-280130-ewqe9edq 30 13 IFN IFN NNP cord-280130-ewqe9edq 30 14 induction induction NN cord-280130-ewqe9edq 30 15 [ [ -LRB- cord-280130-ewqe9edq 30 16 15 15 CD cord-280130-ewqe9edq 30 17 ] ] -RRB- cord-280130-ewqe9edq 30 18 , , , cord-280130-ewqe9edq 30 19 suggesting suggest VBG cord-280130-ewqe9edq 30 20 a a DT cord-280130-ewqe9edq 30 21 similar similar JJ cord-280130-ewqe9edq 30 22 mode mode NN cord-280130-ewqe9edq 30 23 of of IN cord-280130-ewqe9edq 30 24 action action NN cord-280130-ewqe9edq 30 25 . . . cord-280130-ewqe9edq 31 1 Thus thus RB cord-280130-ewqe9edq 31 2 , , , cord-280130-ewqe9edq 31 3 RNA RNA NNP cord-280130-ewqe9edq 31 4 binding bind VBG cord-280130-ewqe9edq 31 5 by by IN cord-280130-ewqe9edq 31 6 these these DT cord-280130-ewqe9edq 31 7 viral viral JJ cord-280130-ewqe9edq 31 8 IFN IFN NNP cord-280130-ewqe9edq 31 9 antagonists antagonist NNS cord-280130-ewqe9edq 31 10 appears appear VBZ cord-280130-ewqe9edq 31 11 to to TO cord-280130-ewqe9edq 31 12 be be VB cord-280130-ewqe9edq 31 13 contributing contribute VBG cord-280130-ewqe9edq 31 14 to to IN cord-280130-ewqe9edq 31 15 their -PRON- PRP$ cord-280130-ewqe9edq 31 16 IFN IFN NNP cord-280130-ewqe9edq 31 17 antagonism antagonism NN cord-280130-ewqe9edq 31 18 without without IN cord-280130-ewqe9edq 31 19 being be VBG cord-280130-ewqe9edq 31 20 sufficient sufficient JJ cord-280130-ewqe9edq 31 21 . . . cord-280130-ewqe9edq 32 1 An an DT cord-280130-ewqe9edq 32 2 IFN IFN NNP cord-280130-ewqe9edq 32 3 induction induction NN cord-280130-ewqe9edq 32 4 antagonist antagonist NN cord-280130-ewqe9edq 32 5 devoid devoid JJ cord-280130-ewqe9edq 32 6 of of IN cord-280130-ewqe9edq 32 7 any any DT cord-280130-ewqe9edq 32 8 RNA RNA NNP cord-280130-ewqe9edq 32 9 - - HYPH cord-280130-ewqe9edq 32 10 binding bind VBG cord-280130-ewqe9edq 32 11 activity activity NN cord-280130-ewqe9edq 32 12 is be VBZ cord-280130-ewqe9edq 32 13 the the DT cord-280130-ewqe9edq 32 14 V V NNP cord-280130-ewqe9edq 32 15 protein protein NN cord-280130-ewqe9edq 32 16 of of IN cord-280130-ewqe9edq 32 17 the the DT cord-280130-ewqe9edq 32 18 paramyxovirus paramyxovirus NNP cord-280130-ewqe9edq 32 19 SV5 SV5 NNP cord-280130-ewqe9edq 32 20 . . . cord-280130-ewqe9edq 33 1 This this DT cord-280130-ewqe9edq 33 2 small small JJ cord-280130-ewqe9edq 33 3 protein protein NN cord-280130-ewqe9edq 33 4 inhibits inhibit VBZ cord-280130-ewqe9edq 33 5 IFN IFN NNP cord-280130-ewqe9edq 33 6 induction induction NN cord-280130-ewqe9edq 33 7 by by IN cord-280130-ewqe9edq 33 8 sequestering sequester VBG cord-280130-ewqe9edq 33 9 the the DT cord-280130-ewqe9edq 33 10 RIG rig NN cord-280130-ewqe9edq 33 11 - - HYPH cord-280130-ewqe9edq 33 12 I i NN cord-280130-ewqe9edq 33 13 - - HYPH cord-280130-ewqe9edq 33 14 related relate VBN cord-280130-ewqe9edq 33 15 RNA RNA NNP cord-280130-ewqe9edq 33 16 sensor sensor NN cord-280130-ewqe9edq 33 17 MDA-5 MDA-5 NNP cord-280130-ewqe9edq 34 1 [ [ -LRB- cord-280130-ewqe9edq 34 2 28 28 CD cord-280130-ewqe9edq 34 3 , , , cord-280130-ewqe9edq 34 4 29 29 CD cord-280130-ewqe9edq 34 5 ] ] -RRB- cord-280130-ewqe9edq 34 6 , , , cord-280130-ewqe9edq 34 7 raising raise VBG cord-280130-ewqe9edq 34 8 the the DT cord-280130-ewqe9edq 34 9 question question NN cord-280130-ewqe9edq 34 10 how how WRB cord-280130-ewqe9edq 34 11 SV5 sv5 JJ cord-280130-ewqe9edq 34 12 deals deal NNS cord-280130-ewqe9edq 34 13 with with IN cord-280130-ewqe9edq 34 14 the the DT cord-280130-ewqe9edq 34 15 parallel parallel JJ cord-280130-ewqe9edq 34 16 RIG rig NN cord-280130-ewqe9edq 34 17 - - : cord-280130-ewqe9edq 34 18 I -PRON- PRP cord-280130-ewqe9edq 34 19 pathway pathway NN cord-280130-ewqe9edq 34 20 . . . cord-280130-ewqe9edq 35 1 This this DT cord-280130-ewqe9edq 35 2 paramyxovirus paramyxovirus JJ cord-280130-ewqe9edq 35 3 - - HYPH cord-280130-ewqe9edq 35 4 specific specific JJ cord-280130-ewqe9edq 35 5 problem problem NN cord-280130-ewqe9edq 35 6 can can MD cord-280130-ewqe9edq 35 7 be be VB cord-280130-ewqe9edq 35 8 avoided avoid VBN cord-280130-ewqe9edq 35 9 by by IN cord-280130-ewqe9edq 35 10 blocking block VBG cord-280130-ewqe9edq 35 11 components component NNS cord-280130-ewqe9edq 35 12 of of IN cord-280130-ewqe9edq 35 13 the the DT cord-280130-ewqe9edq 35 14 signaling signal VBG cord-280130-ewqe9edq 35 15 pathway pathway NN cord-280130-ewqe9edq 35 16 which which WDT cord-280130-ewqe9edq 35 17 are be VBP cord-280130-ewqe9edq 35 18 situated situate VBN cord-280130-ewqe9edq 35 19 further further RB cord-280130-ewqe9edq 35 20 downstream downstream RB cord-280130-ewqe9edq 35 21 and and CC cord-280130-ewqe9edq 35 22 therefore therefore RB cord-280130-ewqe9edq 35 23 needed need VBN cord-280130-ewqe9edq 35 24 by by IN cord-280130-ewqe9edq 35 25 both both DT cord-280130-ewqe9edq 35 26 RIG rig NN cord-280130-ewqe9edq 35 27 - - : cord-280130-ewqe9edq 35 28 I -PRON- PRP cord-280130-ewqe9edq 35 29 and and CC cord-280130-ewqe9edq 35 30 MDA-5 MDA-5 NNP cord-280130-ewqe9edq 35 31 . . . cord-280130-ewqe9edq 36 1 The the DT cord-280130-ewqe9edq 36 2 next next JJ cord-280130-ewqe9edq 36 3 in in IN cord-280130-ewqe9edq 36 4 line line NN cord-280130-ewqe9edq 36 5 , , , cord-280130-ewqe9edq 36 6 the the DT cord-280130-ewqe9edq 36 7 adaptor adaptor NN cord-280130-ewqe9edq 36 8 protein protein NN cord-280130-ewqe9edq 36 9 IPS-1 IPS-1 NNP cord-280130-ewqe9edq 36 10 , , , cord-280130-ewqe9edq 36 11 connects connect VBZ cord-280130-ewqe9edq 36 12 the the DT cord-280130-ewqe9edq 36 13 RNA RNA NNP cord-280130-ewqe9edq 36 14 sensors sensor NNS cord-280130-ewqe9edq 36 15 with with IN cord-280130-ewqe9edq 36 16 the the DT cord-280130-ewqe9edq 36 17 IRF-3 IRF-3 NNP cord-280130-ewqe9edq 36 18 kinases kinase NNS cord-280130-ewqe9edq 36 19 TBK-1 TBK-1 NNP cord-280130-ewqe9edq 36 20 / / SYM cord-280130-ewqe9edq 36 21 IKK-3 IKK-3 NNP cord-280130-ewqe9edq 36 22 and and CC cord-280130-ewqe9edq 36 23 is be VBZ cord-280130-ewqe9edq 36 24 specifically specifically RB cord-280130-ewqe9edq 36 25 cleaved cleave VBN cord-280130-ewqe9edq 36 26 by by IN cord-280130-ewqe9edq 36 27 the the DT cord-280130-ewqe9edq 36 28 NS3 ns3 RB cord-280130-ewqe9edq 36 29 - - HYPH cord-280130-ewqe9edq 36 30 4A 4a CD cord-280130-ewqe9edq 36 31 protease protease NN cord-280130-ewqe9edq 36 32 of of IN cord-280130-ewqe9edq 36 33 hepatitis hepatitis NN cord-280130-ewqe9edq 36 34 C C NNP cord-280130-ewqe9edq 36 35 virus virus NN cord-280130-ewqe9edq 36 36 [ [ -LRB- cord-280130-ewqe9edq 36 37 30 30 CD cord-280130-ewqe9edq 36 38 , , , cord-280130-ewqe9edq 36 39 31 31 CD cord-280130-ewqe9edq 36 40 ] ] -RRB- cord-280130-ewqe9edq 36 41 . . . cord-280130-ewqe9edq 37 1 The the DT cord-280130-ewqe9edq 37 2 activation activation NN cord-280130-ewqe9edq 37 3 of of IN cord-280130-ewqe9edq 37 4 IRF-3 IRF-3 NNP cord-280130-ewqe9edq 37 5 by by IN cord-280130-ewqe9edq 37 6 TBK-1 TBK-1 NNP cord-280130-ewqe9edq 37 7 is be VBZ cord-280130-ewqe9edq 37 8 prevented prevent VBN cord-280130-ewqe9edq 37 9 by by IN cord-280130-ewqe9edq 37 10 the the DT cord-280130-ewqe9edq 37 11 phosphoprotein phosphoprotein NN cord-280130-ewqe9edq 37 12 P p NN cord-280130-ewqe9edq 37 13 of of IN cord-280130-ewqe9edq 37 14 Rabies Rabies NNP cord-280130-ewqe9edq 37 15 virus virus NN cord-280130-ewqe9edq 37 16 [ [ -LRB- cord-280130-ewqe9edq 37 17 32 32 CD cord-280130-ewqe9edq 37 18 ] ] -RRB- cord-280130-ewqe9edq 37 19 and and CC cord-280130-ewqe9edq 37 20 the the DT cord-280130-ewqe9edq 37 21 G1 G1 NNP cord-280130-ewqe9edq 37 22 glycoprotein glycoprotein NN cord-280130-ewqe9edq 37 23 of of IN cord-280130-ewqe9edq 37 24 the the DT cord-280130-ewqe9edq 37 25 hantavirus hantavirus NN cord-280130-ewqe9edq 37 26 NY-1 ny-1 NN cord-280130-ewqe9edq 37 27 [ [ -LRB- cord-280130-ewqe9edq 37 28 33 33 CD cord-280130-ewqe9edq 37 29 ] ] -RRB- cord-280130-ewqe9edq 37 30 . . . cord-280130-ewqe9edq 38 1 IRF-3 IRF-3 NNP cord-280130-ewqe9edq 38 2 itself -PRON- PRP cord-280130-ewqe9edq 38 3 is be VBZ cord-280130-ewqe9edq 38 4 degraded degrade VBN cord-280130-ewqe9edq 38 5 by by IN cord-280130-ewqe9edq 38 6 the the DT cord-280130-ewqe9edq 38 7 NPro NPro NNP cord-280130-ewqe9edq 38 8 proteins protein NNS cord-280130-ewqe9edq 38 9 of of IN cord-280130-ewqe9edq 38 10 classical classical JJ cord-280130-ewqe9edq 38 11 swine swine NN cord-280130-ewqe9edq 38 12 fever fever NN cord-280130-ewqe9edq 38 13 virus virus NN cord-280130-ewqe9edq 38 14 and and CC cord-280130-ewqe9edq 38 15 of of IN cord-280130-ewqe9edq 38 16 bovine bovine JJ cord-280130-ewqe9edq 38 17 viral viral JJ cord-280130-ewqe9edq 38 18 diarrhea diarrhea NN cord-280130-ewqe9edq 38 19 virus virus NN cord-280130-ewqe9edq 38 20 [ [ -LRB- cord-280130-ewqe9edq 38 21 34e37 34e37 CD cord-280130-ewqe9edq 38 22 ] ] -RRB- cord-280130-ewqe9edq 38 23 . . . cord-280130-ewqe9edq 39 1 Also also RB cord-280130-ewqe9edq 39 2 , , , cord-280130-ewqe9edq 39 3 the the DT cord-280130-ewqe9edq 39 4 E6 E6 NNP cord-280130-ewqe9edq 39 5 protein protein NN cord-280130-ewqe9edq 39 6 of of IN cord-280130-ewqe9edq 39 7 human human JJ cord-280130-ewqe9edq 39 8 papilloma papilloma NN cord-280130-ewqe9edq 39 9 virus virus NN cord-280130-ewqe9edq 39 10 16 16 CD cord-280130-ewqe9edq 39 11 binds bind VBZ cord-280130-ewqe9edq 39 12 and and CC cord-280130-ewqe9edq 39 13 inactivates inactivate VBZ cord-280130-ewqe9edq 39 14 IRF-3 IRF-3 NNP cord-280130-ewqe9edq 39 15 [ [ -LRB- cord-280130-ewqe9edq 39 16 38 38 CD cord-280130-ewqe9edq 39 17 ] ] -RRB- cord-280130-ewqe9edq 39 18 , , , cord-280130-ewqe9edq 39 19 and and CC cord-280130-ewqe9edq 39 20 human human JJ cord-280130-ewqe9edq 39 21 herpes herpes NN cord-280130-ewqe9edq 39 22 virus virus NN cord-280130-ewqe9edq 39 23 8 8 CD cord-280130-ewqe9edq 39 24 ( ( -LRB- cord-280130-ewqe9edq 39 25 HHV-8 HHV-8 NNP cord-280130-ewqe9edq 39 26 ) ) -RRB- cord-280130-ewqe9edq 39 27 expresses express VBZ cord-280130-ewqe9edq 39 28 several several JJ cord-280130-ewqe9edq 39 29 IRF IRF NNP cord-280130-ewqe9edq 39 30 homologues homologue NNS cord-280130-ewqe9edq 39 31 , , , cord-280130-ewqe9edq 39 32 termed term VBD cord-280130-ewqe9edq 39 33 vIRFs virfs NN cord-280130-ewqe9edq 39 34 , , , cord-280130-ewqe9edq 39 35 which which WDT cord-280130-ewqe9edq 39 36 exert exert VBP cord-280130-ewqe9edq 39 37 a a DT cord-280130-ewqe9edq 39 38 dominant dominant JJ cord-280130-ewqe9edq 39 39 - - HYPH cord-280130-ewqe9edq 39 40 negative negative JJ cord-280130-ewqe9edq 39 41 effect effect NN cord-280130-ewqe9edq 39 42 [ [ -LRB- cord-280130-ewqe9edq 39 43 39e45 39e45 CD cord-280130-ewqe9edq 39 44 ] ] -RRB- cord-280130-ewqe9edq 39 45 . . . cord-280130-ewqe9edq 40 1 Target target NN cord-280130-ewqe9edq 40 2 - - HYPH cord-280130-ewqe9edq 40 3 specific specific JJ cord-280130-ewqe9edq 40 4 IFN IFN NNP cord-280130-ewqe9edq 40 5 - - HYPH cord-280130-ewqe9edq 40 6 escape escape NN cord-280130-ewqe9edq 40 7 strategies strategy NNS cord-280130-ewqe9edq 40 8 are be VBP cord-280130-ewqe9edq 40 9 often often RB cord-280130-ewqe9edq 40 10 pursued pursue VBN cord-280130-ewqe9edq 40 11 by by IN cord-280130-ewqe9edq 40 12 viruses virus NNS cord-280130-ewqe9edq 40 13 causing cause VBG cord-280130-ewqe9edq 40 14 persistent persistent JJ cord-280130-ewqe9edq 40 15 infections infection NNS cord-280130-ewqe9edq 40 16 , , , cord-280130-ewqe9edq 40 17 e.g. e.g. IN cord-280130-ewqe9edq 40 18 herpes herpes NN cord-280130-ewqe9edq 40 19 viruses virus NNS cord-280130-ewqe9edq 40 20 . . . cord-280130-ewqe9edq 41 1 By by IN cord-280130-ewqe9edq 41 2 contrast contrast NN cord-280130-ewqe9edq 41 3 , , , cord-280130-ewqe9edq 41 4 many many JJ cord-280130-ewqe9edq 41 5 viruses virus NNS cord-280130-ewqe9edq 41 6 which which WDT cord-280130-ewqe9edq 41 7 lytically lytically RB cord-280130-ewqe9edq 41 8 infect infect VBP cord-280130-ewqe9edq 41 9 the the DT cord-280130-ewqe9edq 41 10 host host NN cord-280130-ewqe9edq 41 11 cell cell NN cord-280130-ewqe9edq 41 12 simply simply RB cord-280130-ewqe9edq 41 13 impose impose VBP cord-280130-ewqe9edq 41 14 a a DT cord-280130-ewqe9edq 41 15 general general JJ cord-280130-ewqe9edq 41 16 block block NN cord-280130-ewqe9edq 41 17 on on IN cord-280130-ewqe9edq 41 18 host host NN cord-280130-ewqe9edq 41 19 cell cell NN cord-280130-ewqe9edq 41 20 transcription transcription NN cord-280130-ewqe9edq 41 21 and and CC cord-280130-ewqe9edq 41 22 translation translation NN cord-280130-ewqe9edq 41 23 . . . cord-280130-ewqe9edq 42 1 For for IN cord-280130-ewqe9edq 42 2 example example NN cord-280130-ewqe9edq 42 3 , , , cord-280130-ewqe9edq 42 4 the the DT cord-280130-ewqe9edq 42 5 non non JJ cord-280130-ewqe9edq 42 6 - - JJ cord-280130-ewqe9edq 42 7 structural structural JJ cord-280130-ewqe9edq 42 8 NSs nss NN cord-280130-ewqe9edq 42 9 proteins protein NNS cord-280130-ewqe9edq 42 10 of of IN cord-280130-ewqe9edq 42 11 the the DT cord-280130-ewqe9edq 42 12 Rift Rift NNP cord-280130-ewqe9edq 42 13 Valley Valley NNP cord-280130-ewqe9edq 42 14 Fever Fever NNP cord-280130-ewqe9edq 42 15 virus virus NN cord-280130-ewqe9edq 42 16 and and CC cord-280130-ewqe9edq 42 17 Bunyamwera Bunyamwera NNP cord-280130-ewqe9edq 42 18 virus virus NN cord-280130-ewqe9edq 42 19 interfere interfere VBP cord-280130-ewqe9edq 42 20 with with IN cord-280130-ewqe9edq 42 21 the the DT cord-280130-ewqe9edq 42 22 basic basic JJ cord-280130-ewqe9edq 42 23 cellular cellular JJ cord-280130-ewqe9edq 42 24 transcription transcription NN cord-280130-ewqe9edq 42 25 machinery machinery NN cord-280130-ewqe9edq 42 26 [ [ -LRB- cord-280130-ewqe9edq 42 27 46e48 46e48 CD cord-280130-ewqe9edq 42 28 ] ] -RRB- cord-280130-ewqe9edq 42 29 . . . cord-280130-ewqe9edq 43 1 Although although IN cord-280130-ewqe9edq 43 2 this this DT cord-280130-ewqe9edq 43 3 strategy strategy NN cord-280130-ewqe9edq 43 4 appears appear VBZ cord-280130-ewqe9edq 43 5 to to TO cord-280130-ewqe9edq 43 6 be be VB cord-280130-ewqe9edq 43 7 unspecific unspecific JJ cord-280130-ewqe9edq 43 8 , , , cord-280130-ewqe9edq 43 9 in in IN cord-280130-ewqe9edq 43 10 vivo vivo NN cord-280130-ewqe9edq 43 11 experiments experiment NNS cord-280130-ewqe9edq 43 12 clearly clearly RB cord-280130-ewqe9edq 43 13 demonstrated demonstrate VBD cord-280130-ewqe9edq 43 14 that that IN cord-280130-ewqe9edq 43 15 the the DT cord-280130-ewqe9edq 43 16 biological biological JJ cord-280130-ewqe9edq 43 17 purpose purpose NN cord-280130-ewqe9edq 43 18 of of IN cord-280130-ewqe9edq 43 19 this this DT cord-280130-ewqe9edq 43 20 broad broad JJ cord-280130-ewqe9edq 43 21 - - HYPH cord-280130-ewqe9edq 43 22 band band NN cord-280130-ewqe9edq 43 23 shut shut NN cord-280130-ewqe9edq 43 24 - - HYPH cord-280130-ewqe9edq 43 25 off off NN cord-280130-ewqe9edq 43 26 is be VBZ cord-280130-ewqe9edq 43 27 to to TO cord-280130-ewqe9edq 43 28 inhibit inhibit VB cord-280130-ewqe9edq 43 29 IFN IFN NNP cord-280130-ewqe9edq 43 30 synthesis synthesis NN cord-280130-ewqe9edq 43 31 [ [ -LRB- cord-280130-ewqe9edq 43 32 49 49 CD cord-280130-ewqe9edq 43 33 , , , cord-280130-ewqe9edq 43 34 50 50 CD cord-280130-ewqe9edq 43 35 ] ] -RRB- cord-280130-ewqe9edq 43 36 . . . cord-280130-ewqe9edq 44 1 The the DT cord-280130-ewqe9edq 44 2 matrix matrix NN cord-280130-ewqe9edq 44 3 ( ( -LRB- cord-280130-ewqe9edq 44 4 M M NNP cord-280130-ewqe9edq 44 5 ) ) -RRB- cord-280130-ewqe9edq 44 6 protein protein NN cord-280130-ewqe9edq 44 7 of of IN cord-280130-ewqe9edq 44 8 vesicular vesicular JJ cord-280130-ewqe9edq 44 9 stomatitis stomatitis NN cord-280130-ewqe9edq 44 10 virus virus NN cord-280130-ewqe9edq 44 11 ( ( -LRB- cord-280130-ewqe9edq 44 12 VSV VSV NNP cord-280130-ewqe9edq 44 13 ) ) -RRB- cord-280130-ewqe9edq 44 14 is be VBZ cord-280130-ewqe9edq 44 15 also also RB cord-280130-ewqe9edq 44 16 a a DT cord-280130-ewqe9edq 44 17 potent potent JJ cord-280130-ewqe9edq 44 18 host host NN cord-280130-ewqe9edq 44 19 cell cell NN cord-280130-ewqe9edq 44 20 shutoff shutoff NN cord-280130-ewqe9edq 44 21 factor factor NN cord-280130-ewqe9edq 44 22 which which WDT cord-280130-ewqe9edq 44 23 inhibits inhibit VBZ cord-280130-ewqe9edq 44 24 basal basal NN cord-280130-ewqe9edq 44 25 transcription transcription NN cord-280130-ewqe9edq 44 26 [ [ -LRB- cord-280130-ewqe9edq 44 27 51 51 CD cord-280130-ewqe9edq 44 28 ] ] -RRB- cord-280130-ewqe9edq 44 29 , , , cord-280130-ewqe9edq 44 30 impairs impair VBZ cord-280130-ewqe9edq 44 31 nuclear nuclear JJ cord-280130-ewqe9edq 44 32 - - HYPH cord-280130-ewqe9edq 44 33 cytoplasmic cytoplasmic JJ cord-280130-ewqe9edq 44 34 transport transport NN cord-280130-ewqe9edq 44 35 of of IN cord-280130-ewqe9edq 44 36 RNAs rna NNS cord-280130-ewqe9edq 44 37 and and CC cord-280130-ewqe9edq 44 38 proteins protein NNS cord-280130-ewqe9edq 44 39 [ [ -LRB- cord-280130-ewqe9edq 44 40 52 52 CD cord-280130-ewqe9edq 44 41 ] ] -RRB- cord-280130-ewqe9edq 44 42 , , , cord-280130-ewqe9edq 44 43 and and CC cord-280130-ewqe9edq 44 44 inactivates inactivate VBZ cord-280130-ewqe9edq 44 45 translation translation NN cord-280130-ewqe9edq 44 46 factors factor NNS cord-280130-ewqe9edq 44 47 [ [ -LRB- cord-280130-ewqe9edq 44 48 53 53 CD cord-280130-ewqe9edq 44 49 ] ] -RRB- cord-280130-ewqe9edq 44 50 . . . cord-280130-ewqe9edq 45 1 As as IN cord-280130-ewqe9edq 45 2 is be VBZ cord-280130-ewqe9edq 45 3 the the DT cord-280130-ewqe9edq 45 4 case case NN cord-280130-ewqe9edq 45 5 with with IN cord-280130-ewqe9edq 45 6 bunyavirus bunyavirus NNP cord-280130-ewqe9edq 45 7 NSs NSs NNP cord-280130-ewqe9edq 45 8 , , , cord-280130-ewqe9edq 45 9 the the DT cord-280130-ewqe9edq 45 10 biological biological JJ cord-280130-ewqe9edq 45 11 significance significance NN cord-280130-ewqe9edq 45 12 of of IN cord-280130-ewqe9edq 45 13 VSV VSV NNP cord-280130-ewqe9edq 45 14 M M NNP cord-280130-ewqe9edq 45 15 - - HYPH cord-280130-ewqe9edq 45 16 mediated mediate VBN cord-280130-ewqe9edq 45 17 shutoff shutoff NN cord-280130-ewqe9edq 45 18 is be VBZ cord-280130-ewqe9edq 45 19 to to TO cord-280130-ewqe9edq 45 20 suppress suppress VB cord-280130-ewqe9edq 45 21 IFN IFN NNP cord-280130-ewqe9edq 45 22 induction induction NN cord-280130-ewqe9edq 45 23 [ [ -LRB- cord-280130-ewqe9edq 45 24 54 54 CD cord-280130-ewqe9edq 45 25 , , , cord-280130-ewqe9edq 45 26 55 55 CD cord-280130-ewqe9edq 45 27 ] ] -RRB- cord-280130-ewqe9edq 45 28 . . . cord-280130-ewqe9edq 46 1 Also also RB cord-280130-ewqe9edq 46 2 , , , cord-280130-ewqe9edq 46 3 proteinases proteinase NNS cord-280130-ewqe9edq 46 4 of of IN cord-280130-ewqe9edq 46 5 Picornaviruses Picornaviruses NNP cord-280130-ewqe9edq 46 6 ( ( -LRB- cord-280130-ewqe9edq 46 7 e.g. e.g. RB cord-280130-ewqe9edq 46 8 Foot Foot NNP cord-280130-ewqe9edq 46 9 and and CC cord-280130-ewqe9edq 46 10 Mouth Mouth NNP cord-280130-ewqe9edq 46 11 disease disease NN cord-280130-ewqe9edq 46 12 virus virus NN cord-280130-ewqe9edq 46 13 , , , cord-280130-ewqe9edq 46 14 Theiler Theiler NNP cord-280130-ewqe9edq 46 15 's 's POS cord-280130-ewqe9edq 46 16 virus virus NN cord-280130-ewqe9edq 46 17 , , , cord-280130-ewqe9edq 46 18 Polio Polio NNP cord-280130-ewqe9edq 46 19 virus virus NN cord-280130-ewqe9edq 46 20 ) ) -RRB- cord-280130-ewqe9edq 46 21 and and CC cord-280130-ewqe9edq 46 22 Pestiviruses Pestiviruses NNP cord-280130-ewqe9edq 46 23 ( ( -LRB- cord-280130-ewqe9edq 46 24 e.g. e.g. RB cord-280130-ewqe9edq 46 25 Classical Classical NNP cord-280130-ewqe9edq 46 26 Swine Swine NNP cord-280130-ewqe9edq 46 27 fever fever NN cord-280130-ewqe9edq 46 28 virus virus NN cord-280130-ewqe9edq 46 29 ) ) -RRB- cord-280130-ewqe9edq 46 30 cause cause VB cord-280130-ewqe9edq 46 31 a a DT cord-280130-ewqe9edq 46 32 shutoff shutoff NN cord-280130-ewqe9edq 46 33 - - : cord-280130-ewqe9edq 46 34 of of IN cord-280130-ewqe9edq 46 35 the the DT cord-280130-ewqe9edq 46 36 host host NN cord-280130-ewqe9edq 46 37 cell cell NN cord-280130-ewqe9edq 46 38 metabolism metabolism NN cord-280130-ewqe9edq 46 39 to to TO cord-280130-ewqe9edq 46 40 interfere interfere VB cord-280130-ewqe9edq 46 41 with with IN cord-280130-ewqe9edq 46 42 the the DT cord-280130-ewqe9edq 46 43 IFN IFN NNP cord-280130-ewqe9edq 46 44 response response NN cord-280130-ewqe9edq 46 45 [ [ -LRB- cord-280130-ewqe9edq 46 46 37,56e60 37,56e60 CD cord-280130-ewqe9edq 46 47 ] ] -RRB- cord-280130-ewqe9edq 46 48 . . . cord-280130-ewqe9edq 47 1 Interestingly interestingly RB cord-280130-ewqe9edq 47 2 , , , cord-280130-ewqe9edq 47 3 the the DT cord-280130-ewqe9edq 47 4 non non JJ cord-280130-ewqe9edq 47 5 - - JJ cord-280130-ewqe9edq 47 6 structural structural JJ cord-280130-ewqe9edq 47 7 protein protein NN cord-280130-ewqe9edq 47 8 NS1 NS1 NNS cord-280130-ewqe9edq 47 9 of of IN cord-280130-ewqe9edq 47 10 influenza influenza NN cord-280130-ewqe9edq 47 11 A a DT cord-280130-ewqe9edq 47 12 virus virus NN cord-280130-ewqe9edq 47 13 also also RB cord-280130-ewqe9edq 47 14 impairs impair VBZ cord-280130-ewqe9edq 47 15 the the DT cord-280130-ewqe9edq 47 16 post post JJ cord-280130-ewqe9edq 47 17 - - JJ cord-280130-ewqe9edq 47 18 transcriptional transcriptional JJ cord-280130-ewqe9edq 47 19 processing processing NN cord-280130-ewqe9edq 47 20 and and CC cord-280130-ewqe9edq 47 21 nuclear nuclear JJ cord-280130-ewqe9edq 47 22 export export NN cord-280130-ewqe9edq 47 23 of of IN cord-280130-ewqe9edq 47 24 cellular cellular JJ cord-280130-ewqe9edq 47 25 pre pre NNS cord-280130-ewqe9edq 47 26 - - NNS cord-280130-ewqe9edq 47 27 mRNAs mrnas JJ cord-280130-ewqe9edq 47 28 [ [ -LRB- cord-280130-ewqe9edq 47 29 61e63 61e63 CD cord-280130-ewqe9edq 47 30 ] ] -RRB- cord-280130-ewqe9edq 47 31 in in IN cord-280130-ewqe9edq 47 32 order order NN cord-280130-ewqe9edq 47 33 to to TO cord-280130-ewqe9edq 47 34 counteract counteract VB cord-280130-ewqe9edq 47 35 the the DT cord-280130-ewqe9edq 47 36 antiviral antiviral JJ cord-280130-ewqe9edq 47 37 host host NN cord-280130-ewqe9edq 47 38 response response NN cord-280130-ewqe9edq 47 39 [ [ -LRB- cord-280130-ewqe9edq 47 40 64 64 CD cord-280130-ewqe9edq 47 41 , , , cord-280130-ewqe9edq 47 42 65 65 CD cord-280130-ewqe9edq 47 43 ] ] -RRB- cord-280130-ewqe9edq 47 44 . . . cord-280130-ewqe9edq 48 1 Thus thus RB cord-280130-ewqe9edq 48 2 , , , cord-280130-ewqe9edq 48 3 NS1 ns1 UH cord-280130-ewqe9edq 48 4 is be VBZ cord-280130-ewqe9edq 48 5 a a DT cord-280130-ewqe9edq 48 6 versatile versatile JJ cord-280130-ewqe9edq 48 7 protein protein NN cord-280130-ewqe9edq 48 8 with with IN cord-280130-ewqe9edq 48 9 the the DT cord-280130-ewqe9edq 48 10 ability ability NN cord-280130-ewqe9edq 48 11 to to TO cord-280130-ewqe9edq 48 12 prevent prevent VB cord-280130-ewqe9edq 48 13 IFN IFN NNP cord-280130-ewqe9edq 48 14 induction induction NN cord-280130-ewqe9edq 48 15 both both DT cord-280130-ewqe9edq 48 16 by by IN cord-280130-ewqe9edq 48 17 IFN IFN NNP cord-280130-ewqe9edq 48 18 pathway pathway NN cord-280130-ewqe9edq 48 19 - - HYPH cord-280130-ewqe9edq 48 20 specific specific JJ cord-280130-ewqe9edq 48 21 and and CC cord-280130-ewqe9edq 48 22 by by IN cord-280130-ewqe9edq 48 23 less less RBR cord-280130-ewqe9edq 48 24 specific specific JJ cord-280130-ewqe9edq 48 25 means mean NNS cord-280130-ewqe9edq 48 26 , , , cord-280130-ewqe9edq 48 27 and and CC cord-280130-ewqe9edq 48 28 recent recent JJ cord-280130-ewqe9edq 48 29 studies study NNS cord-280130-ewqe9edq 48 30 suggest suggest VBP cord-280130-ewqe9edq 48 31 that that IN cord-280130-ewqe9edq 48 32 there there EX cord-280130-ewqe9edq 48 33 is be VBZ cord-280130-ewqe9edq 48 34 a a DT cord-280130-ewqe9edq 48 35 surprisingly surprisingly RB cord-280130-ewqe9edq 48 36 great great JJ cord-280130-ewqe9edq 48 37 strain strain NN cord-280130-ewqe9edq 48 38 - - HYPH cord-280130-ewqe9edq 48 39 specific specific JJ cord-280130-ewqe9edq 48 40 variation variation NN cord-280130-ewqe9edq 48 41 in in IN cord-280130-ewqe9edq 48 42 these these DT cord-280130-ewqe9edq 48 43 activities activity NNS cord-280130-ewqe9edq 48 44 [ [ -LRB- cord-280130-ewqe9edq 48 45 66 66 CD cord-280130-ewqe9edq 48 46 ] ] -RRB- cord-280130-ewqe9edq 48 47 . . . cord-280130-ewqe9edq 49 1 IFN IFN NNP cord-280130-ewqe9edq 49 2 - - HYPH cord-280130-ewqe9edq 49 3 b b NNP cord-280130-ewqe9edq 49 4 and and CC cord-280130-ewqe9edq 49 5 the the DT cord-280130-ewqe9edq 49 6 multiple multiple JJ cord-280130-ewqe9edq 49 7 IFN IFN NNP cord-280130-ewqe9edq 49 8 - - HYPH cord-280130-ewqe9edq 49 9 a a DT cord-280130-ewqe9edq 49 10 subspecies subspecies NN cord-280130-ewqe9edq 49 11 activate activate VBP cord-280130-ewqe9edq 49 12 a a DT cord-280130-ewqe9edq 49 13 common common JJ cord-280130-ewqe9edq 49 14 type type NN cord-280130-ewqe9edq 49 15 I -PRON- PRP cord-280130-ewqe9edq 49 16 IFN IFN NNP cord-280130-ewqe9edq 49 17 receptor receptor NN cord-280130-ewqe9edq 49 18 ( ( -LRB- cord-280130-ewqe9edq 49 19 IFNAR IFNAR NNP cord-280130-ewqe9edq 49 20 ) ) -RRB- cord-280130-ewqe9edq 49 21 which which WDT cord-280130-ewqe9edq 49 22 signals signal VBZ cord-280130-ewqe9edq 49 23 to to IN cord-280130-ewqe9edq 49 24 the the DT cord-280130-ewqe9edq 49 25 nucleus nucleus NN cord-280130-ewqe9edq 49 26 through through IN cord-280130-ewqe9edq 49 27 the the DT cord-280130-ewqe9edq 49 28 so so RB cord-280130-ewqe9edq 49 29 - - HYPH cord-280130-ewqe9edq 49 30 called call VBN cord-280130-ewqe9edq 49 31 JAK JAK NNP cord-280130-ewqe9edq 49 32 - - HYPH cord-280130-ewqe9edq 49 33 STAT STAT NNP cord-280130-ewqe9edq 49 34 pathway pathway NN cord-280130-ewqe9edq 49 35 ( ( -LRB- cord-280130-ewqe9edq 49 36 Fig Fig NNP cord-280130-ewqe9edq 49 37 . . NNP cord-280130-ewqe9edq 49 38 2 2 CD cord-280130-ewqe9edq 49 39 ) ) -RRB- cord-280130-ewqe9edq 49 40 . . . cord-280130-ewqe9edq 50 1 The the DT cord-280130-ewqe9edq 50 2 STAT stat NN cord-280130-ewqe9edq 50 3 proteins protein NNS cord-280130-ewqe9edq 50 4 are be VBP cord-280130-ewqe9edq 50 5 latent latent JJ cord-280130-ewqe9edq 50 6 cytoplasmic cytoplasmic JJ cord-280130-ewqe9edq 50 7 transcription transcription NN cord-280130-ewqe9edq 50 8 factors factor NNS cord-280130-ewqe9edq 50 9 which which WDT cord-280130-ewqe9edq 50 10 become become VBP cord-280130-ewqe9edq 50 11 phosphorylated phosphorylate VBN cord-280130-ewqe9edq 50 12 by by IN cord-280130-ewqe9edq 50 13 the the DT cord-280130-ewqe9edq 50 14 Janus Janus NNP cord-280130-ewqe9edq 50 15 kinases kinase NNS cord-280130-ewqe9edq 50 16 JAK-1 JAK-1 NNP cord-280130-ewqe9edq 50 17 and and CC cord-280130-ewqe9edq 50 18 TYK-2 TYK-2 NNP cord-280130-ewqe9edq 50 19 [ [ -LRB- cord-280130-ewqe9edq 50 20 67 67 CD cord-280130-ewqe9edq 50 21 ] ] -RRB- cord-280130-ewqe9edq 50 22 . . . cord-280130-ewqe9edq 51 1 Phosphorylated Phosphorylated NNP cord-280130-ewqe9edq 51 2 STAT-1 STAT-1 NNPS cord-280130-ewqe9edq 51 3 and and CC cord-280130-ewqe9edq 51 4 STAT-2 STAT-2 NNP cord-280130-ewqe9edq 51 5 recruit recruit NNP cord-280130-ewqe9edq 51 6 a a DT cord-280130-ewqe9edq 51 7 third third JJ cord-280130-ewqe9edq 51 8 factor factor NN cord-280130-ewqe9edq 51 9 , , , cord-280130-ewqe9edq 51 10 IRF-9 IRF-9 NNP cord-280130-ewqe9edq 51 11 , , , cord-280130-ewqe9edq 51 12 to to TO cord-280130-ewqe9edq 51 13 form form VB cord-280130-ewqe9edq 51 14 a a DT cord-280130-ewqe9edq 51 15 complex complex NN cord-280130-ewqe9edq 51 16 known know VBN cord-280130-ewqe9edq 51 17 as as IN cord-280130-ewqe9edq 51 18 IFN IFN NNP cord-280130-ewqe9edq 51 19 - - HYPH cord-280130-ewqe9edq 51 20 stimulated stimulate VBN cord-280130-ewqe9edq 51 21 gene gene NN cord-280130-ewqe9edq 51 22 factor factor NN cord-280130-ewqe9edq 51 23 3 3 CD cord-280130-ewqe9edq 51 24 ( ( -LRB- cord-280130-ewqe9edq 51 25 ISGF-3 ISGF-3 NNP cord-280130-ewqe9edq 51 26 ) ) -RRB- cord-280130-ewqe9edq 51 27 which which WDT cord-280130-ewqe9edq 51 28 translocates translocate VBZ cord-280130-ewqe9edq 51 29 to to IN cord-280130-ewqe9edq 51 30 the the DT cord-280130-ewqe9edq 51 31 nucleus nucleus NN cord-280130-ewqe9edq 51 32 and and CC cord-280130-ewqe9edq 51 33 binds bind VBZ cord-280130-ewqe9edq 51 34 to to IN cord-280130-ewqe9edq 51 35 the the DT cord-280130-ewqe9edq 51 36 IFN IFN NNP cord-280130-ewqe9edq 51 37 - - HYPH cord-280130-ewqe9edq 51 38 stimulated stimulate VBN cord-280130-ewqe9edq 51 39 response response NN cord-280130-ewqe9edq 51 40 element element NN cord-280130-ewqe9edq 51 41 ( ( -LRB- cord-280130-ewqe9edq 51 42 ISRE ISRE NNP cord-280130-ewqe9edq 51 43 ) ) -RRB- cord-280130-ewqe9edq 51 44 in in IN cord-280130-ewqe9edq 51 45 the the DT cord-280130-ewqe9edq 51 46 promoter promoter NN cord-280130-ewqe9edq 51 47 region region NN cord-280130-ewqe9edq 51 48 of of IN cord-280130-ewqe9edq 51 49 interferon interferon NN cord-280130-ewqe9edq 51 50 - - HYPH cord-280130-ewqe9edq 51 51 stimulated stimulate VBN cord-280130-ewqe9edq 51 52 genes gene NNS cord-280130-ewqe9edq 51 53 ( ( -LRB- cord-280130-ewqe9edq 51 54 ISGs ISGs NNP cord-280130-ewqe9edq 51 55 ) ) -RRB- cord-280130-ewqe9edq 51 56 . . . cord-280130-ewqe9edq 52 1 The the DT cord-280130-ewqe9edq 52 2 IFN IFN NNP cord-280130-ewqe9edq 52 3 signal signal NN cord-280130-ewqe9edq 52 4 transduction transduction NN cord-280130-ewqe9edq 52 5 pathway pathway NN cord-280130-ewqe9edq 52 6 represents represent VBZ cord-280130-ewqe9edq 52 7 another another DT cord-280130-ewqe9edq 52 8 important important JJ cord-280130-ewqe9edq 52 9 target target NN cord-280130-ewqe9edq 52 10 of of IN cord-280130-ewqe9edq 52 11 viruses virus NNS cord-280130-ewqe9edq 52 12 ( ( -LRB- cord-280130-ewqe9edq 52 13 Fig fig NN cord-280130-ewqe9edq 52 14 . . NNP cord-280130-ewqe9edq 52 15 2 2 CD cord-280130-ewqe9edq 52 16 ) ) -RRB- cord-280130-ewqe9edq 52 17 . . . cord-280130-ewqe9edq 53 1 Members member NNS cord-280130-ewqe9edq 53 2 of of IN cord-280130-ewqe9edq 53 3 the the DT cord-280130-ewqe9edq 53 4 paramyxovirus paramyxovirus NNP cord-280130-ewqe9edq 53 5 family family NN cord-280130-ewqe9edq 53 6 , , , cord-280130-ewqe9edq 53 7 which which WDT cord-280130-ewqe9edq 53 8 contains contain VBZ cord-280130-ewqe9edq 53 9 mainly mainly RB cord-280130-ewqe9edq 53 10 important important JJ cord-280130-ewqe9edq 53 11 pathogens pathogen NNS cord-280130-ewqe9edq 53 12 , , , cord-280130-ewqe9edq 53 13 encode encode VB cord-280130-ewqe9edq 53 14 two two CD cord-280130-ewqe9edq 53 15 different different JJ cord-280130-ewqe9edq 53 16 ( ( -LRB- cord-280130-ewqe9edq 53 17 but but CC cord-280130-ewqe9edq 53 18 genetically genetically RB cord-280130-ewqe9edq 53 19 related related JJ cord-280130-ewqe9edq 53 20 ) ) -RRB- cord-280130-ewqe9edq 53 21 proteins protein NNS cord-280130-ewqe9edq 53 22 named name VBN cord-280130-ewqe9edq 53 23 C c NN cord-280130-ewqe9edq 53 24 and and CC cord-280130-ewqe9edq 53 25 V v NN cord-280130-ewqe9edq 53 26 which which WDT cord-280130-ewqe9edq 53 27 interfere interfere VBP cord-280130-ewqe9edq 53 28 with with IN cord-280130-ewqe9edq 53 29 STAT stat NN cord-280130-ewqe9edq 53 30 function function NN cord-280130-ewqe9edq 53 31 . . . cord-280130-ewqe9edq 54 1 Depending depend VBG cord-280130-ewqe9edq 54 2 on on IN cord-280130-ewqe9edq 54 3 the the DT cord-280130-ewqe9edq 54 4 virus virus NN cord-280130-ewqe9edq 54 5 species species NN cord-280130-ewqe9edq 54 6 , , , cord-280130-ewqe9edq 54 7 these these DT cord-280130-ewqe9edq 54 8 IFN IFN NNP cord-280130-ewqe9edq 54 9 antagonists antagonist NNS cord-280130-ewqe9edq 54 10 act act VBP cord-280130-ewqe9edq 54 11 either either CC cord-280130-ewqe9edq 54 12 by by IN cord-280130-ewqe9edq 54 13 binding bind VBG cord-280130-ewqe9edq 54 14 the the DT cord-280130-ewqe9edq 54 15 STAT stat NN cord-280130-ewqe9edq 54 16 proteins protein NNS cord-280130-ewqe9edq 54 17 , , , cord-280130-ewqe9edq 54 18 by by IN cord-280130-ewqe9edq 54 19 inducing induce VBG cord-280130-ewqe9edq 54 20 their -PRON- PRP$ cord-280130-ewqe9edq 54 21 degradation degradation NN cord-280130-ewqe9edq 54 22 , , , cord-280130-ewqe9edq 54 23 or or CC cord-280130-ewqe9edq 54 24 by by IN cord-280130-ewqe9edq 54 25 inhibiting inhibit VBG cord-280130-ewqe9edq 54 26 the the DT cord-280130-ewqe9edq 54 27 JAK JAK NNP cord-280130-ewqe9edq 54 28 kinases kinase NNS cord-280130-ewqe9edq 54 29 [ [ -LRB- cord-280130-ewqe9edq 54 30 68e82 68e82 CD cord-280130-ewqe9edq 54 31 ] ] -RRB- cord-280130-ewqe9edq 54 32 . . . cord-280130-ewqe9edq 55 1 The the DT cord-280130-ewqe9edq 55 2 P p NN cord-280130-ewqe9edq 55 3 protein protein NN cord-280130-ewqe9edq 55 4 of of IN cord-280130-ewqe9edq 55 5 Rabies Rabies NNP cord-280130-ewqe9edq 55 6 virus virus NN cord-280130-ewqe9edq 55 7 binds bind VBZ cord-280130-ewqe9edq 55 8 to to IN cord-280130-ewqe9edq 55 9 activated activate VBN cord-280130-ewqe9edq 55 10 STAT1 stat1 NN cord-280130-ewqe9edq 55 11 and and CC cord-280130-ewqe9edq 55 12 STAT2 STAT2 NNS cord-280130-ewqe9edq 55 13 and and CC cord-280130-ewqe9edq 55 14 retains retain VBZ cord-280130-ewqe9edq 55 15 them -PRON- PRP cord-280130-ewqe9edq 55 16 in in IN cord-280130-ewqe9edq 55 17 the the DT cord-280130-ewqe9edq 55 18 cytoplasm cytoplasm NN cord-280130-ewqe9edq 55 19 [ [ -LRB- cord-280130-ewqe9edq 55 20 83 83 CD cord-280130-ewqe9edq 55 21 ] ] -RRB- cord-280130-ewqe9edq 55 22 . . . cord-280130-ewqe9edq 56 1 Thus thus RB cord-280130-ewqe9edq 56 2 , , , cord-280130-ewqe9edq 56 3 the the DT cord-280130-ewqe9edq 56 4 paramyxoviral paramyxoviral JJ cord-280130-ewqe9edq 56 5 V V NNP cord-280130-ewqe9edq 56 6 protein protein NN cord-280130-ewqe9edq 56 7 as as RB cord-280130-ewqe9edq 56 8 well well RB cord-280130-ewqe9edq 56 9 as as IN cord-280130-ewqe9edq 56 10 the the DT cord-280130-ewqe9edq 56 11 rabies rabies NN cord-280130-ewqe9edq 56 12 virus virus NN cord-280130-ewqe9edq 56 13 P p NN cord-280130-ewqe9edq 56 14 protein protein NN cord-280130-ewqe9edq 56 15 have have VBP cord-280130-ewqe9edq 56 16 a a DT cord-280130-ewqe9edq 56 17 dual dual JJ cord-280130-ewqe9edq 56 18 anti anti JJ cord-280130-ewqe9edq 56 19 - - JJ cord-280130-ewqe9edq 56 20 IFN IFN NNP cord-280130-ewqe9edq 56 21 function function NN cord-280130-ewqe9edq 56 22 as as IN cord-280130-ewqe9edq 56 23 they -PRON- PRP cord-280130-ewqe9edq 56 24 block block VBP cord-280130-ewqe9edq 56 25 both both CC cord-280130-ewqe9edq 56 26 IFN IFN NNP cord-280130-ewqe9edq 56 27 induction induction NN cord-280130-ewqe9edq 56 28 ( ( -LRB- cord-280130-ewqe9edq 56 29 see see VB cord-280130-ewqe9edq 56 30 above above RB cord-280130-ewqe9edq 56 31 ) ) -RRB- cord-280130-ewqe9edq 56 32 and and CC cord-280130-ewqe9edq 56 33 STAT stat NN cord-280130-ewqe9edq 56 34 signaling signal VBG cord-280130-ewqe9edq 56 35 . . . cord-280130-ewqe9edq 57 1 Ebola Ebola NNP cord-280130-ewqe9edq 57 2 virus virus NN cord-280130-ewqe9edq 57 3 , , , cord-280130-ewqe9edq 57 4 by by IN cord-280130-ewqe9edq 57 5 contrast contrast NN cord-280130-ewqe9edq 57 6 uses use VBZ cord-280130-ewqe9edq 57 7 a a DT cord-280130-ewqe9edq 57 8 different different JJ cord-280130-ewqe9edq 57 9 protein protein NN cord-280130-ewqe9edq 57 10 , , , cord-280130-ewqe9edq 57 11 VP24 VP24 NNP cord-280130-ewqe9edq 57 12 , , , cord-280130-ewqe9edq 57 13 to to TO cord-280130-ewqe9edq 57 14 block block VB cord-280130-ewqe9edq 57 15 nuclear nuclear JJ cord-280130-ewqe9edq 57 16 import import NN cord-280130-ewqe9edq 57 17 of of IN cord-280130-ewqe9edq 57 18 STAT stat NN cord-280130-ewqe9edq 57 19 by by IN cord-280130-ewqe9edq 57 20 interacting interact VBG cord-280130-ewqe9edq 57 21 with with IN cord-280130-ewqe9edq 57 22 the the DT cord-280130-ewqe9edq 57 23 transporter transporter NN cord-280130-ewqe9edq 57 24 protein protein NN cord-280130-ewqe9edq 57 25 karyopherin karyopherin NNP cord-280130-ewqe9edq 57 26 alpha1 alpha1 NN cord-280130-ewqe9edq 57 27 [ [ -LRB- cord-280130-ewqe9edq 57 28 84 84 CD cord-280130-ewqe9edq 57 29 ] ] -RRB- cord-280130-ewqe9edq 57 30 . . . cord-280130-ewqe9edq 58 1 STAT stat NN cord-280130-ewqe9edq 58 2 signaling signaling NN cord-280130-ewqe9edq 58 3 is be VBZ cord-280130-ewqe9edq 58 4 also also RB cord-280130-ewqe9edq 58 5 disturbed disturb VBN cord-280130-ewqe9edq 58 6 by by IN cord-280130-ewqe9edq 58 7 viruses virus NNS cord-280130-ewqe9edq 58 8 causing cause VBG cord-280130-ewqe9edq 58 9 persistent persistent JJ cord-280130-ewqe9edq 58 10 infections infection NNS cord-280130-ewqe9edq 58 11 , , , cord-280130-ewqe9edq 58 12 such such JJ cord-280130-ewqe9edq 58 13 as as IN cord-280130-ewqe9edq 58 14 Hepatitis Hepatitis NNP cord-280130-ewqe9edq 58 15 C C NNP cord-280130-ewqe9edq 58 16 virus virus NN cord-280130-ewqe9edq 58 17 [ [ -LRB- cord-280130-ewqe9edq 58 18 _SP cord-280130-ewqe9edq 58 19 The the DT cord-280130-ewqe9edq 58 20 dsRNA dsrna RB cord-280130-ewqe9edq 58 21 - - HYPH cord-280130-ewqe9edq 58 22 binding bind VBG cord-280130-ewqe9edq 58 23 proteins protein NNS cord-280130-ewqe9edq 58 24 mentioned mention VBN cord-280130-ewqe9edq 58 25 above above RB cord-280130-ewqe9edq 58 26 also also RB cord-280130-ewqe9edq 58 27 serve serve VBP cord-280130-ewqe9edq 58 28 a a DT cord-280130-ewqe9edq 58 29 second second JJ cord-280130-ewqe9edq 58 30 purpose purpose NN cord-280130-ewqe9edq 58 31 , , , cord-280130-ewqe9edq 58 32 namely namely RB cord-280130-ewqe9edq 58 33 the the DT cord-280130-ewqe9edq 58 34 inhibition inhibition NN cord-280130-ewqe9edq 58 35 of of IN cord-280130-ewqe9edq 58 36 the the DT cord-280130-ewqe9edq 58 37 dsRNA dsrna NN cord-280130-ewqe9edq 58 38 - - HYPH cord-280130-ewqe9edq 58 39 activated activate VBN cord-280130-ewqe9edq 58 40 antiviral antiviral JJ cord-280130-ewqe9edq 58 41 enzymes enzyme NNS cord-280130-ewqe9edq 58 42 . . . cord-280130-ewqe9edq 59 1 This this DT cord-280130-ewqe9edq 59 2 has have VBZ cord-280130-ewqe9edq 59 3 been be VBN cord-280130-ewqe9edq 59 4 demonstrated demonstrate VBN cord-280130-ewqe9edq 59 5 for for IN cord-280130-ewqe9edq 59 6 the the DT cord-280130-ewqe9edq 59 7 influenza influenza NN cord-280130-ewqe9edq 59 8 virus virus NN cord-280130-ewqe9edq 59 9 NS1 ns1 CD cord-280130-ewqe9edq 59 10 [ [ -LRB- cord-280130-ewqe9edq 59 11 11,12,95e99 11,12,95e99 CD cord-280130-ewqe9edq 59 12 ] ] -RRB- cord-280130-ewqe9edq 59 13 , , , cord-280130-ewqe9edq 59 14 the the DT cord-280130-ewqe9edq 59 15 poxvirus poxvirus NNP cord-280130-ewqe9edq 59 16 E3L e3l NN cord-280130-ewqe9edq 59 17 [ [ -LRB- cord-280130-ewqe9edq 59 18 97 97 CD cord-280130-ewqe9edq 59 19 ] ] -RRB- cord-280130-ewqe9edq 59 20 , , , cord-280130-ewqe9edq 59 21 the the DT cord-280130-ewqe9edq 59 22 reovirus reovirus NNP cord-280130-ewqe9edq 59 23 sigma3 sigma3 NNP cord-280130-ewqe9edq 59 24 [ [ -LRB- cord-280130-ewqe9edq 59 25 100 100 CD cord-280130-ewqe9edq 59 26 ] ] -RRB- cord-280130-ewqe9edq 59 27 , , . cord-280130-ewqe9edq 60 1 the the DT cord-280130-ewqe9edq 60 2 herpesvirus herpesvirus NN cord-280130-ewqe9edq 60 3 US11 US11 NNP cord-280130-ewqe9edq 60 4 [ [ -LRB- cord-280130-ewqe9edq 60 5 19 19 CD cord-280130-ewqe9edq 60 6 , , , cord-280130-ewqe9edq 60 7 101 101 CD cord-280130-ewqe9edq 60 8 ] ] -RRB- cord-280130-ewqe9edq 60 9 , , , cord-280130-ewqe9edq 60 10 and and CC cord-280130-ewqe9edq 60 11 the the DT cord-280130-ewqe9edq 60 12 dsRNA dsrna NN cord-280130-ewqe9edq 60 13 - - HYPH cord-280130-ewqe9edq 60 14 binding bind VBG cord-280130-ewqe9edq 60 15 proteins protein NNS cord-280130-ewqe9edq 60 16 of of IN cord-280130-ewqe9edq 60 17 human human JJ cord-280130-ewqe9edq 60 18 and and CC cord-280130-ewqe9edq 60 19 murine murine JJ cord-280130-ewqe9edq 60 20 cytomegaloviruses cytomegalovirus NNS cord-280130-ewqe9edq 60 21 [ [ -LRB- cord-280130-ewqe9edq 60 22 20 20 CD cord-280130-ewqe9edq 60 23 , , , cord-280130-ewqe9edq 60 24 21 21 CD cord-280130-ewqe9edq 60 25 , , , cord-280130-ewqe9edq 60 26 102 102 CD cord-280130-ewqe9edq 60 27 ] ] -RRB- cord-280130-ewqe9edq 60 28 . . . cord-280130-ewqe9edq 61 1 Importantly importantly RB cord-280130-ewqe9edq 61 2 , , , cord-280130-ewqe9edq 61 3 also also RB cord-280130-ewqe9edq 61 4 for for IN cord-280130-ewqe9edq 61 5 this this DT cord-280130-ewqe9edq 61 6 anti anti JJ cord-280130-ewqe9edq 61 7 - - JJ cord-280130-ewqe9edq 61 8 IFN IFN NNP cord-280130-ewqe9edq 61 9 effector effector NN cord-280130-ewqe9edq 61 10 function function NN cord-280130-ewqe9edq 61 11 more more RBR cord-280130-ewqe9edq 61 12 that that IN cord-280130-ewqe9edq 61 13 just just RB cord-280130-ewqe9edq 61 14 dsRNA dsrna NN cord-280130-ewqe9edq 61 15 binding binding NN cord-280130-ewqe9edq 61 16 appears appear VBZ cord-280130-ewqe9edq 61 17 to to TO cord-280130-ewqe9edq 61 18 be be VB cord-280130-ewqe9edq 61 19 necessary necessary JJ cord-280130-ewqe9edq 61 20 , , , cord-280130-ewqe9edq 61 21 since since IN cord-280130-ewqe9edq 61 22 in in IN cord-280130-ewqe9edq 61 23 many many JJ cord-280130-ewqe9edq 61 24 cases case NNS cord-280130-ewqe9edq 61 25 a a DT cord-280130-ewqe9edq 61 26 direct direct JJ cord-280130-ewqe9edq 61 27 interaction interaction NN cord-280130-ewqe9edq 61 28 with with IN cord-280130-ewqe9edq 61 29 e.g. e.g. JJ cord-280130-ewqe9edq 61 30 PKR PKR NNP cord-280130-ewqe9edq 61 31 has have VBZ cord-280130-ewqe9edq 61 32 been be VBN cord-280130-ewqe9edq 61 33 demonstrated demonstrate VBN cord-280130-ewqe9edq 61 34 ( ( -LRB- cord-280130-ewqe9edq 61 35 reviewed review VBN cord-280130-ewqe9edq 61 36 in in IN cord-280130-ewqe9edq 61 37 Ref Ref NNP cord-280130-ewqe9edq 61 38 . . . cord-280130-ewqe9edq 62 1 [ [ -LRB- cord-280130-ewqe9edq 62 2 7 7 CD cord-280130-ewqe9edq 62 3 ] ] -RRB- cord-280130-ewqe9edq 62 4 ) ) -RRB- cord-280130-ewqe9edq 62 5 . . . cord-280130-ewqe9edq 63 1 Sequestering sequestering NN cord-280130-ewqe9edq 63 2 dsRNA dsrna JJ cord-280130-ewqe9edq 63 3 may may MD cord-280130-ewqe9edq 63 4 also also RB cord-280130-ewqe9edq 63 5 inhibit inhibit VB cord-280130-ewqe9edq 63 6 the the DT cord-280130-ewqe9edq 63 7 2e5OAS 2e5oas CD cord-280130-ewqe9edq 63 8 pathway pathway NN cord-280130-ewqe9edq 63 9 and and CC cord-280130-ewqe9edq 63 10 ADAR ADAR NNP cord-280130-ewqe9edq 63 11 , , , cord-280130-ewqe9edq 63 12 although although IN cord-280130-ewqe9edq 63 13 this this DT cord-280130-ewqe9edq 63 14 has have VBZ cord-280130-ewqe9edq 63 15 only only RB cord-280130-ewqe9edq 63 16 been be VBN cord-280130-ewqe9edq 63 17 shown show VBN cord-280130-ewqe9edq 63 18 in in IN cord-280130-ewqe9edq 63 19 a a DT cord-280130-ewqe9edq 63 20 few few JJ cord-280130-ewqe9edq 63 21 cases case NNS cord-280130-ewqe9edq 63 22 [ [ -LRB- cord-280130-ewqe9edq 63 23 12 12 CD cord-280130-ewqe9edq 63 24 , , , cord-280130-ewqe9edq 63 25 14 14 CD cord-280130-ewqe9edq 63 26 ] ] -RRB- cord-280130-ewqe9edq 63 27 . . . cord-280130-ewqe9edq 64 1 dsRNA dsrna JJ cord-280130-ewqe9edq 65 1 -independent -independent JJ cord-280130-ewqe9edq 65 2 inhibition inhibition NN cord-280130-ewqe9edq 65 3 of of IN cord-280130-ewqe9edq 65 4 the the DT cord-280130-ewqe9edq 65 5 RNaseL RNaseL NNP cord-280130-ewqe9edq 65 6 system system NN cord-280130-ewqe9edq 65 7 is be VBZ cord-280130-ewqe9edq 65 8 achieved achieve VBN cord-280130-ewqe9edq 65 9 by by IN cord-280130-ewqe9edq 65 10 the the DT cord-280130-ewqe9edq 65 11 ICP0 ICP0 NNP cord-280130-ewqe9edq 65 12 protein protein NN cord-280130-ewqe9edq 65 13 of of IN cord-280130-ewqe9edq 65 14 herpes herpes NNP cord-280130-ewqe9edq 65 15 simplex simplex NNP cord-280130-ewqe9edq 65 16 virus virus NN cord-280130-ewqe9edq 65 17 [ [ -LRB- cord-280130-ewqe9edq 65 18 103 103 CD cord-280130-ewqe9edq 65 19 ] ] -RRB- cord-280130-ewqe9edq 65 20 and and CC cord-280130-ewqe9edq 65 21 by by IN cord-280130-ewqe9edq 65 22 upregulation upregulation NN cord-280130-ewqe9edq 65 23 of of IN cord-280130-ewqe9edq 65 24 RLI RLI NNP cord-280130-ewqe9edq 65 25 , , , cord-280130-ewqe9edq 65 26 a a DT cord-280130-ewqe9edq 65 27 cellular cellular JJ cord-280130-ewqe9edq 65 28 inhibitor inhibitor NN cord-280130-ewqe9edq 65 29 of of IN cord-280130-ewqe9edq 65 30 RNaseL RNaseL NNP cord-280130-ewqe9edq 65 31 , , , cord-280130-ewqe9edq 65 32 in in IN cord-280130-ewqe9edq 65 33 HIV HIV NNP cord-280130-ewqe9edq 65 34 - - : cord-280130-ewqe9edq 65 35 and and CC cord-280130-ewqe9edq 65 36 Picornavirus Picornavirus NNP cord-280130-ewqe9edq 65 37 - - HYPH cord-280130-ewqe9edq 65 38 infected infect VBN cord-280130-ewqe9edq 65 39 cells cell NNS cord-280130-ewqe9edq 65 40 [ [ -LRB- cord-280130-ewqe9edq 65 41 104 104 CD cord-280130-ewqe9edq 65 42 , , , cord-280130-ewqe9edq 65 43 105 105 CD cord-280130-ewqe9edq 65 44 ] ] -RRB- cord-280130-ewqe9edq 65 45 . . . cord-280130-ewqe9edq 66 1 PKR PKR NNP cord-280130-ewqe9edq 66 2 is be VBZ cord-280130-ewqe9edq 66 3 also also RB cord-280130-ewqe9edq 66 4 attacked attack VBN cord-280130-ewqe9edq 66 5 by by IN cord-280130-ewqe9edq 66 6 other other JJ cord-280130-ewqe9edq 66 7 means mean NNS cord-280130-ewqe9edq 66 8 . . . cord-280130-ewqe9edq 67 1 The the DT cord-280130-ewqe9edq 67 2 g34.5 g34.5 NNP cord-280130-ewqe9edq 67 3 protein protein NN cord-280130-ewqe9edq 67 4 of of IN cord-280130-ewqe9edq 67 5 Herpes Herpes NNP cord-280130-ewqe9edq 67 6 simplex simplex NN cord-280130-ewqe9edq 67 7 virus virus NN cord-280130-ewqe9edq 67 8 triggers trigger VBZ cord-280130-ewqe9edq 67 9 the the DT cord-280130-ewqe9edq 67 10 dephosphorylation dephosphorylation NN cord-280130-ewqe9edq 67 11 of of IN cord-280130-ewqe9edq 67 12 eIF-2a eif-2a NN cord-280130-ewqe9edq 67 13 , , , cord-280130-ewqe9edq 67 14 thus thus RB cord-280130-ewqe9edq 67 15 reverting revert VBG cord-280130-ewqe9edq 67 16 the the DT cord-280130-ewqe9edq 67 17 translational translational JJ cord-280130-ewqe9edq 67 18 block block NN cord-280130-ewqe9edq 67 19 established establish VBN cord-280130-ewqe9edq 67 20 by by IN cord-280130-ewqe9edq 67 21 PKR PKR NNP cord-280130-ewqe9edq 67 22 [ [ -LRB- cord-280130-ewqe9edq 67 23 106 106 CD cord-280130-ewqe9edq 67 24 ] ] -RRB- cord-280130-ewqe9edq 67 25 . . . cord-280130-ewqe9edq 68 1 The the DT cord-280130-ewqe9edq 68 2 E2 E2 NNP cord-280130-ewqe9edq 68 3 protein protein NN cord-280130-ewqe9edq 68 4 of of IN cord-280130-ewqe9edq 68 5 Hepatitis Hepatitis NNP cord-280130-ewqe9edq 68 6 C C NNP cord-280130-ewqe9edq 68 7 virus virus NN cord-280130-ewqe9edq 68 8 [ [ -LRB- cord-280130-ewqe9edq 68 9 107 107 CD cord-280130-ewqe9edq 68 10 ] ] -RRB- cord-280130-ewqe9edq 68 11 , , , cord-280130-ewqe9edq 68 12 the the DT cord-280130-ewqe9edq 68 13 Tat Tat NNP cord-280130-ewqe9edq 68 14 protein protein NN cord-280130-ewqe9edq 68 15 of of IN cord-280130-ewqe9edq 68 16 HIV HIV NNP cord-280130-ewqe9edq 68 17 [ [ -LRB- cord-280130-ewqe9edq 68 18 108 108 CD cord-280130-ewqe9edq 68 19 ] ] -RRB- cord-280130-ewqe9edq 68 20 and and CC cord-280130-ewqe9edq 68 21 the the DT cord-280130-ewqe9edq 68 22 K3L K3L NNP cord-280130-ewqe9edq 68 23 protein protein NN cord-280130-ewqe9edq 68 24 of of IN cord-280130-ewqe9edq 69 1 Vaccinia vaccinia NN cord-280130-ewqe9edq 69 2 virus virus NN cord-280130-ewqe9edq 69 3 [ [ -LRB- cord-280130-ewqe9edq 69 4 109 109 CD cord-280130-ewqe9edq 69 5 ] ] -RRB- cord-280130-ewqe9edq 69 6 act act NN cord-280130-ewqe9edq 69 7 as as IN cord-280130-ewqe9edq 69 8 pseudosubstrates pseudosubstrates NNP cord-280130-ewqe9edq 69 9 for for IN cord-280130-ewqe9edq 69 10 PKR PKR NNP cord-280130-ewqe9edq 69 11 . . . cord-280130-ewqe9edq 70 1 Another another DT cord-280130-ewqe9edq 70 2 strategy strategy NN cord-280130-ewqe9edq 70 3 is be VBZ cord-280130-ewqe9edq 70 4 to to TO cord-280130-ewqe9edq 70 5 encode encode VB cord-280130-ewqe9edq 70 6 small small JJ cord-280130-ewqe9edq 70 7 , , , cord-280130-ewqe9edq 70 8 highly highly RB cord-280130-ewqe9edq 70 9 structured structured JJ cord-280130-ewqe9edq 70 10 RNAs rna NNS cord-280130-ewqe9edq 70 11 which which WDT cord-280130-ewqe9edq 70 12 compete compete VBP cord-280130-ewqe9edq 70 13 with with IN cord-280130-ewqe9edq 70 14 dsRNA dsRNA NNS cord-280130-ewqe9edq 70 15 and and CC cord-280130-ewqe9edq 70 16 inactivate inactivate VB cord-280130-ewqe9edq 70 17 PKR PKR NNP cord-280130-ewqe9edq 70 18 . . . cord-280130-ewqe9edq 71 1 This this DT cord-280130-ewqe9edq 71 2 was be VBD cord-280130-ewqe9edq 71 3 demonstrated demonstrate VBN cord-280130-ewqe9edq 71 4 for for IN cord-280130-ewqe9edq 71 5 adenoviruses adenovirus NNS cord-280130-ewqe9edq 71 6 [ [ -LRB- cord-280130-ewqe9edq 71 7 110 110 CD cord-280130-ewqe9edq 71 8 ] ] -RRB- cord-280130-ewqe9edq 71 9 , , , cord-280130-ewqe9edq 71 10 Hepatitis Hepatitis NNP cord-280130-ewqe9edq 71 11 C C NNP cord-280130-ewqe9edq 71 12 virus virus NN cord-280130-ewqe9edq 71 13 [ [ -LRB- cord-280130-ewqe9edq 71 14 111 111 CD cord-280130-ewqe9edq 71 15 ] ] -RRB- cord-280130-ewqe9edq 71 16 , , , cord-280130-ewqe9edq 71 17 Epstein Epstein NNP cord-280130-ewqe9edq 71 18 - - HYPH cord-280130-ewqe9edq 71 19 Barr Barr NNP cord-280130-ewqe9edq 71 20 virus virus NN cord-280130-ewqe9edq 71 21 [ [ -LRB- cord-280130-ewqe9edq 71 22 112 112 CD cord-280130-ewqe9edq 71 23 ] ] -RRB- cord-280130-ewqe9edq 71 24 , , , cord-280130-ewqe9edq 71 25 and and CC cord-280130-ewqe9edq 71 26 HIV HIV NNP cord-280130-ewqe9edq 71 27 [ [ -LRB- cord-280130-ewqe9edq 71 28 113 113 CD cord-280130-ewqe9edq 71 29 ] ] -RRB- cord-280130-ewqe9edq 71 30 . . . cord-280130-ewqe9edq 72 1 However however RB cord-280130-ewqe9edq 72 2 , , , cord-280130-ewqe9edq 72 3 for for IN cord-280130-ewqe9edq 72 4 Epstein Epstein NNP cord-280130-ewqe9edq 72 5 - - HYPH cord-280130-ewqe9edq 72 6 Barr Barr NNP cord-280130-ewqe9edq 72 7 virus virus NN cord-280130-ewqe9edq 72 8 it -PRON- PRP cord-280130-ewqe9edq 72 9 was be VBD cord-280130-ewqe9edq 72 10 shown show VBN cord-280130-ewqe9edq 72 11 that that IN cord-280130-ewqe9edq 72 12 the the DT cord-280130-ewqe9edq 72 13 PKR PKR NNP cord-280130-ewqe9edq 72 14 inhibition inhibition NN cord-280130-ewqe9edq 72 15 by by IN cord-280130-ewqe9edq 72 16 the the DT cord-280130-ewqe9edq 72 17 so so RB cord-280130-ewqe9edq 72 18 - - HYPH cord-280130-ewqe9edq 72 19 called call VBN cord-280130-ewqe9edq 72 20 EBER EBER NNP cord-280130-ewqe9edq 72 21 RNAs rna NNS cord-280130-ewqe9edq 72 22 observed observe VBD cord-280130-ewqe9edq 72 23 in in IN cord-280130-ewqe9edq 72 24 vitro vitro FW cord-280130-ewqe9edq 72 25 does do VBZ cord-280130-ewqe9edq 72 26 not not RB cord-280130-ewqe9edq 72 27 occur occur VB cord-280130-ewqe9edq 72 28 in in IN cord-280130-ewqe9edq 72 29 vivo vivo NN cord-280130-ewqe9edq 72 30 [ [ -LRB- cord-280130-ewqe9edq 72 31 114 114 CD cord-280130-ewqe9edq 72 32 ] ] -RRB- cord-280130-ewqe9edq 72 33 , , , cord-280130-ewqe9edq 72 34 suggesting suggest VBG cord-280130-ewqe9edq 72 35 that that IN cord-280130-ewqe9edq 72 36 EBERs eber NNS cord-280130-ewqe9edq 72 37 are be VBP cord-280130-ewqe9edq 72 38 important important JJ cord-280130-ewqe9edq 72 39 for for IN cord-280130-ewqe9edq 72 40 other other JJ cord-280130-ewqe9edq 72 41 activities activity NNS cord-280130-ewqe9edq 72 42 such such JJ cord-280130-ewqe9edq 72 43 as as IN cord-280130-ewqe9edq 72 44 inhibition inhibition NN cord-280130-ewqe9edq 72 45 of of IN cord-280130-ewqe9edq 72 46 apoptosis apoptosis NN cord-280130-ewqe9edq 72 47 . . . cord-280130-ewqe9edq 73 1 It -PRON- PRP cord-280130-ewqe9edq 73 2 is be VBZ cord-280130-ewqe9edq 73 3 obvious obvious JJ cord-280130-ewqe9edq 73 4 from from IN cord-280130-ewqe9edq 73 5 the the DT cord-280130-ewqe9edq 73 6 listings listing NNS cord-280130-ewqe9edq 73 7 above above IN cord-280130-ewqe9edq 73 8 that that IN cord-280130-ewqe9edq 73 9 viruses virus NNS cord-280130-ewqe9edq 73 10 have have VBP cord-280130-ewqe9edq 73 11 evolved evolve VBN cord-280130-ewqe9edq 73 12 multiple multiple JJ cord-280130-ewqe9edq 73 13 means mean NNS cord-280130-ewqe9edq 73 14 to to TO cord-280130-ewqe9edq 73 15 disrupt disrupt VB cord-280130-ewqe9edq 73 16 the the DT cord-280130-ewqe9edq 73 17 IFN IFN NNP cord-280130-ewqe9edq 73 18 response response NN cord-280130-ewqe9edq 73 19 . . . cord-280130-ewqe9edq 74 1 In in IN cord-280130-ewqe9edq 74 2 some some DT cord-280130-ewqe9edq 74 3 cases case NNS cord-280130-ewqe9edq 74 4 , , , cord-280130-ewqe9edq 74 5 there there EX cord-280130-ewqe9edq 74 6 are be VBP cord-280130-ewqe9edq 74 7 specialized specialized JJ cord-280130-ewqe9edq 74 8 anti anti JJ cord-280130-ewqe9edq 74 9 - - JJ cord-280130-ewqe9edq 74 10 IFN IFN NNP cord-280130-ewqe9edq 74 11 factors factor NNS cord-280130-ewqe9edq 74 12 such such JJ cord-280130-ewqe9edq 74 13 the the DT cord-280130-ewqe9edq 74 14 non non JJ cord-280130-ewqe9edq 74 15 - - JJ cord-280130-ewqe9edq 74 16 structural structural JJ cord-280130-ewqe9edq 74 17 proteins protein NNS cord-280130-ewqe9edq 74 18 of of IN cord-280130-ewqe9edq 74 19 influenza influenza NN cord-280130-ewqe9edq 74 20 viruses virus NNS cord-280130-ewqe9edq 74 21 . . . cord-280130-ewqe9edq 75 1 In in IN cord-280130-ewqe9edq 75 2 many many JJ cord-280130-ewqe9edq 75 3 other other JJ cord-280130-ewqe9edq 75 4 cases case NNS cord-280130-ewqe9edq 75 5 , , , cord-280130-ewqe9edq 75 6 however however RB cord-280130-ewqe9edq 75 7 , , , cord-280130-ewqe9edq 75 8 viral viral JJ cord-280130-ewqe9edq 75 9 gene gene NN cord-280130-ewqe9edq 75 10 products product NNS cord-280130-ewqe9edq 75 11 with with IN cord-280130-ewqe9edq 75 12 a a DT cord-280130-ewqe9edq 75 13 defined define VBN cord-280130-ewqe9edq 75 14 function function NN cord-280130-ewqe9edq 75 15 in in IN cord-280130-ewqe9edq 75 16 virus virus NN cord-280130-ewqe9edq 75 17 replication replication NN cord-280130-ewqe9edq 75 18 cycle cycle NN cord-280130-ewqe9edq 75 19 can can MD cord-280130-ewqe9edq 75 20 additionally additionally RB cord-280130-ewqe9edq 75 21 acquire acquire VB cord-280130-ewqe9edq 75 22 the the DT cord-280130-ewqe9edq 75 23 ability ability NN cord-280130-ewqe9edq 75 24 to to TO cord-280130-ewqe9edq 75 25 block block VB cord-280130-ewqe9edq 75 26 the the DT cord-280130-ewqe9edq 75 27 IFN IFN NNP cord-280130-ewqe9edq 75 28 system system NN cord-280130-ewqe9edq 75 29 . . . cord-280130-ewqe9edq 76 1 Important important JJ cord-280130-ewqe9edq 76 2 examples example NNS cord-280130-ewqe9edq 76 3 include include VBP cord-280130-ewqe9edq 76 4 the the DT cord-280130-ewqe9edq 76 5 V v NN cord-280130-ewqe9edq 76 6 , , , cord-280130-ewqe9edq 76 7 W W NNP cord-280130-ewqe9edq 76 8 and and CC cord-280130-ewqe9edq 76 9 C C NNP cord-280130-ewqe9edq 76 10 proteins protein NNS cord-280130-ewqe9edq 76 11 of of IN cord-280130-ewqe9edq 76 12 paramyxoviruses paramyxovirus NNS cord-280130-ewqe9edq 76 13 [ [ -LRB- cord-280130-ewqe9edq 76 14 79 79 CD cord-280130-ewqe9edq 76 15 , , , cord-280130-ewqe9edq 76 16 115 115 CD cord-280130-ewqe9edq 76 17 ] ] -RRB- cord-280130-ewqe9edq 76 18 , , , cord-280130-ewqe9edq 76 19 the the DT cord-280130-ewqe9edq 76 20 P p NN cord-280130-ewqe9edq 76 21 protein protein NN cord-280130-ewqe9edq 76 22 of of IN cord-280130-ewqe9edq 76 23 rabies rabies NN cord-280130-ewqe9edq 76 24 virus virus NN cord-280130-ewqe9edq 76 25 [ [ -LRB- cord-280130-ewqe9edq 76 26 32 32 CD cord-280130-ewqe9edq 76 27 , , , cord-280130-ewqe9edq 76 28 83 83 CD cord-280130-ewqe9edq 76 29 ] ] -RRB- cord-280130-ewqe9edq 76 30 and and CC cord-280130-ewqe9edq 76 31 the the DT cord-280130-ewqe9edq 76 32 VP35 VP35 NNP cord-280130-ewqe9edq 76 33 protein protein NN cord-280130-ewqe9edq 76 34 of of IN cord-280130-ewqe9edq 76 35 Ebola Ebola NNP cord-280130-ewqe9edq 76 36 virus virus NN cord-280130-ewqe9edq 76 37 [ [ -LRB- cord-280130-ewqe9edq 76 38 116 116 CD cord-280130-ewqe9edq 76 39 ] ] -RRB- cord-280130-ewqe9edq 76 40 , , , cord-280130-ewqe9edq 76 41 which which WDT cord-280130-ewqe9edq 76 42 are be VBP cord-280130-ewqe9edq 76 43 regulators regulator NNS cord-280130-ewqe9edq 76 44 of of IN cord-280130-ewqe9edq 76 45 the the DT cord-280130-ewqe9edq 76 46 viral viral JJ cord-280130-ewqe9edq 76 47 polymerase polymerase NN cord-280130-ewqe9edq 76 48 . . . cord-280130-ewqe9edq 77 1 Also also RB cord-280130-ewqe9edq 77 2 , , , cord-280130-ewqe9edq 77 3 the the DT cord-280130-ewqe9edq 77 4 matrix matrix NN cord-280130-ewqe9edq 77 5 proteins protein NNS cord-280130-ewqe9edq 77 6 of of IN cord-280130-ewqe9edq 77 7 Thogoto Thogoto NNP cord-280130-ewqe9edq 77 8 virus virus NN cord-280130-ewqe9edq 77 9 [ [ -LRB- cord-280130-ewqe9edq 77 10 117 117 CD cord-280130-ewqe9edq 77 11 ] ] -RRB- cord-280130-ewqe9edq 77 12 and and CC cord-280130-ewqe9edq 77 13 vesicular vesicular JJ cord-280130-ewqe9edq 77 14 stomatitis stomatitis NN cord-280130-ewqe9edq 77 15 virus virus NN cord-280130-ewqe9edq 77 16 [ [ -LRB- cord-280130-ewqe9edq 77 17 58 58 CD cord-280130-ewqe9edq 77 18 ] ] -RRB- cord-280130-ewqe9edq 77 19 , , , cord-280130-ewqe9edq 77 20 the the DT cord-280130-ewqe9edq 77 21 nucleoprotein nucleoprotein NNP cord-280130-ewqe9edq 77 22 of of IN cord-280130-ewqe9edq 77 23 arenaviruses arenaviruses NNP cord-280130-ewqe9edq 77 24 [ [ -LRB- cord-280130-ewqe9edq 77 25 118 118 CD cord-280130-ewqe9edq 77 26 ] ] -RRB- cord-280130-ewqe9edq 77 27 , , , cord-280130-ewqe9edq 77 28 and and CC cord-280130-ewqe9edq 77 29 the the DT cord-280130-ewqe9edq 77 30 glycoprotein glycoprotein NN cord-280130-ewqe9edq 77 31 of of IN cord-280130-ewqe9edq 77 32 hantaviruses hantaviruses NNPS cord-280130-ewqe9edq 77 33 [ [ -LRB- cord-280130-ewqe9edq 77 34 33 33 CD cord-280130-ewqe9edq 77 35 ] ] -RRB- cord-280130-ewqe9edq 77 36 not not RB cord-280130-ewqe9edq 77 37 only only RB cord-280130-ewqe9edq 77 38 have have VBP cord-280130-ewqe9edq 77 39 structural structural JJ cord-280130-ewqe9edq 77 40 functions function NNS cord-280130-ewqe9edq 77 41 , , , cord-280130-ewqe9edq 77 42 but but CC cord-280130-ewqe9edq 77 43 are be VBP cord-280130-ewqe9edq 77 44 IFN IFN NNP cord-280130-ewqe9edq 77 45 antagonists antagonist NNS cord-280130-ewqe9edq 77 46 as as RB cord-280130-ewqe9edq 77 47 well well RB cord-280130-ewqe9edq 77 48 . . . cord-280130-ewqe9edq 78 1 Some some DT cord-280130-ewqe9edq 78 2 viruses virus NNS cord-280130-ewqe9edq 78 3 such such JJ cord-280130-ewqe9edq 78 4 as as IN cord-280130-ewqe9edq 78 5 Dengue Dengue NNP cord-280130-ewqe9edq 78 6 virus virus NN cord-280130-ewqe9edq 78 7 or or CC cord-280130-ewqe9edq 78 8 SARS SARS NNP cord-280130-ewqe9edq 78 9 - - HYPH cord-280130-ewqe9edq 78 10 coronavirus coronavirus NN cord-280130-ewqe9edq 78 11 encode encode VBP cord-280130-ewqe9edq 78 12 a a DT cord-280130-ewqe9edq 78 13 multitude multitude NN cord-280130-ewqe9edq 78 14 of of IN cord-280130-ewqe9edq 78 15 anti anti JJ cord-280130-ewqe9edq 78 16 - - JJ cord-280130-ewqe9edq 78 17 IFN IFN NNP cord-280130-ewqe9edq 78 18 factors factor NNS cord-280130-ewqe9edq 78 19 which which WDT cord-280130-ewqe9edq 78 20 together together RB cord-280130-ewqe9edq 78 21 may may MD cord-280130-ewqe9edq 78 22 strongly strongly RB cord-280130-ewqe9edq 78 23 contribute contribute VB cord-280130-ewqe9edq 78 24 to to IN cord-280130-ewqe9edq 78 25 an an DT cord-280130-ewqe9edq 78 26 enhanced enhance VBN cord-280130-ewqe9edq 78 27 virulence virulence NN cord-280130-ewqe9edq 78 28 [ [ -LRB- cord-280130-ewqe9edq 78 29 119e121 119e121 CD cord-280130-ewqe9edq 78 30 ] ] -RRB- cord-280130-ewqe9edq 78 31 . . . cord-280130-ewqe9edq 79 1 Apparently apparently RB cord-280130-ewqe9edq 79 2 , , , cord-280130-ewqe9edq 79 3 modulating modulate VBG cord-280130-ewqe9edq 79 4 the the DT cord-280130-ewqe9edq 79 5 IFN IFN NNP cord-280130-ewqe9edq 79 6 system system NN cord-280130-ewqe9edq 79 7 can can MD cord-280130-ewqe9edq 79 8 be be VB cord-280130-ewqe9edq 79 9 achieved achieve VBN cord-280130-ewqe9edq 79 10 either either CC cord-280130-ewqe9edq 79 11 by by IN cord-280130-ewqe9edq 79 12 ' ' '' cord-280130-ewqe9edq 79 13 ' ' `` cord-280130-ewqe9edq 79 14 inventing invent VBG cord-280130-ewqe9edq 79 15 ' ' '' cord-280130-ewqe9edq 79 16 ' ' '' cord-280130-ewqe9edq 79 17 one one CD cord-280130-ewqe9edq 79 18 or or CC cord-280130-ewqe9edq 79 19 several several JJ cord-280130-ewqe9edq 79 20 specialized specialized JJ cord-280130-ewqe9edq 79 21 factors factor NNS cord-280130-ewqe9edq 79 22 or or CC cord-280130-ewqe9edq 79 23 by by IN cord-280130-ewqe9edq 79 24 expanding expand VBG cord-280130-ewqe9edq 79 25 the the DT cord-280130-ewqe9edq 79 26 function function NN cord-280130-ewqe9edq 79 27 of of IN cord-280130-ewqe9edq 79 28 existant existant JJ cord-280130-ewqe9edq 79 29 gene gene NN cord-280130-ewqe9edq 79 30 products product NNS cord-280130-ewqe9edq 79 31 . . . cord-280130-ewqe9edq 80 1 Understanding understand VBG cord-280130-ewqe9edq 80 2 the the DT cord-280130-ewqe9edq 80 3 interplay interplay NN cord-280130-ewqe9edq 80 4 between between IN cord-280130-ewqe9edq 80 5 viruses virus NNS cord-280130-ewqe9edq 80 6 and and CC cord-280130-ewqe9edq 80 7 the the DT cord-280130-ewqe9edq 80 8 IFN IFN NNP cord-280130-ewqe9edq 80 9 response response NN cord-280130-ewqe9edq 80 10 can can MD cord-280130-ewqe9edq 80 11 help help VB cord-280130-ewqe9edq 80 12 to to TO cord-280130-ewqe9edq 80 13 design design VB cord-280130-ewqe9edq 80 14 new new JJ cord-280130-ewqe9edq 80 15 strategies strategy NNS cord-280130-ewqe9edq 80 16 for for IN cord-280130-ewqe9edq 80 17 prevention prevention NN cord-280130-ewqe9edq 80 18 and and CC cord-280130-ewqe9edq 80 19 therapy therapy NN cord-280130-ewqe9edq 80 20 . . . cord-280130-ewqe9edq 81 1 Viruses virus NNS cord-280130-ewqe9edq 81 2 unable unable JJ cord-280130-ewqe9edq 81 3 to to TO cord-280130-ewqe9edq 81 4 counteract counteract VB cord-280130-ewqe9edq 81 5 the the DT cord-280130-ewqe9edq 81 6 IFN IFN NNP cord-280130-ewqe9edq 81 7 response response NN cord-280130-ewqe9edq 81 8 are be VBP cord-280130-ewqe9edq 81 9 excellent excellent JJ cord-280130-ewqe9edq 81 10 candidates candidate NNS cord-280130-ewqe9edq 81 11 for for IN cord-280130-ewqe9edq 81 12 live live JJ cord-280130-ewqe9edq 81 13 virus virus NN cord-280130-ewqe9edq 81 14 vaccines vaccine NNS cord-280130-ewqe9edq 81 15 . . . cord-280130-ewqe9edq 82 1 They -PRON- PRP cord-280130-ewqe9edq 82 2 can can MD cord-280130-ewqe9edq 82 3 be be VB cord-280130-ewqe9edq 82 4 grown grow VBN cord-280130-ewqe9edq 82 5 to to IN cord-280130-ewqe9edq 82 6 high high JJ cord-280130-ewqe9edq 82 7 titers titer NNS cord-280130-ewqe9edq 82 8 in in IN cord-280130-ewqe9edq 82 9 IFN IFN NNP cord-280130-ewqe9edq 82 10 - - HYPH cord-280130-ewqe9edq 82 11 deficient deficient JJ cord-280130-ewqe9edq 82 12 cell cell NN cord-280130-ewqe9edq 82 13 cultures culture NNS cord-280130-ewqe9edq 82 14 but but CC cord-280130-ewqe9edq 82 15 are be VBP cord-280130-ewqe9edq 82 16 attenuated attenuate VBN cord-280130-ewqe9edq 82 17 in in IN cord-280130-ewqe9edq 82 18 vivo vivo NN cord-280130-ewqe9edq 82 19 since since IN cord-280130-ewqe9edq 82 20 they -PRON- PRP cord-280130-ewqe9edq 82 21 elicit elicit VBP cord-280130-ewqe9edq 82 22 a a DT cord-280130-ewqe9edq 82 23 robust robust JJ cord-280130-ewqe9edq 82 24 innate innate JJ cord-280130-ewqe9edq 82 25 and and CC cord-280130-ewqe9edq 82 26 adaptive adaptive JJ cord-280130-ewqe9edq 82 27 immune immune JJ cord-280130-ewqe9edq 82 28 responses response NNS cord-280130-ewqe9edq 82 29 . . . cord-280130-ewqe9edq 83 1 This this DT cord-280130-ewqe9edq 83 2 concept concept NN cord-280130-ewqe9edq 83 3 has have VBZ cord-280130-ewqe9edq 83 4 been be VBN cord-280130-ewqe9edq 83 5 proven prove VBN cord-280130-ewqe9edq 83 6 for for IN cord-280130-ewqe9edq 83 7 influenza influenza NN cord-280130-ewqe9edq 83 8 viruses virus NNS cord-280130-ewqe9edq 83 9 [ [ -LRB- cord-280130-ewqe9edq 83 10 122e125 122e125 CD cord-280130-ewqe9edq 83 11 ] ] -RRB- cord-280130-ewqe9edq 83 12 , , , cord-280130-ewqe9edq 83 13 human human JJ cord-280130-ewqe9edq 83 14 parainfluenza parainfluenza NNP cord-280130-ewqe9edq 83 15 virus virus NNP cord-280130-ewqe9edq 83 16 type type NNP cord-280130-ewqe9edq 83 17 1 1 CD cord-280130-ewqe9edq 83 18 [ [ -LRB- cord-280130-ewqe9edq 83 19 126 126 CD cord-280130-ewqe9edq 83 20 ] ] -RRB- cord-280130-ewqe9edq 83 21 , , , cord-280130-ewqe9edq 83 22 human human JJ cord-280130-ewqe9edq 83 23 and and CC cord-280130-ewqe9edq 83 24 bovine bovine JJ cord-280130-ewqe9edq 83 25 respiratory respiratory JJ cord-280130-ewqe9edq 83 26 syncytial syncytial JJ cord-280130-ewqe9edq 83 27 viruses virus NNS cord-280130-ewqe9edq 83 28 [ [ -LRB- cord-280130-ewqe9edq 83 29 127e129 127e129 CD cord-280130-ewqe9edq 83 30 ] ] -RRB- cord-280130-ewqe9edq 83 31 , , , cord-280130-ewqe9edq 83 32 and and CC cord-280130-ewqe9edq 83 33 may may MD cord-280130-ewqe9edq 83 34 likewise likewise RB cord-280130-ewqe9edq 83 35 apply apply VB cord-280130-ewqe9edq 83 36 to to IN cord-280130-ewqe9edq 83 37 other other JJ cord-280130-ewqe9edq 83 38 viruses virus NNS cord-280130-ewqe9edq 83 39 . . . cord-280130-ewqe9edq 84 1 Oncolytic oncolytic JJ cord-280130-ewqe9edq 84 2 viruses virus NNS cord-280130-ewqe9edq 84 3 designed design VBN cord-280130-ewqe9edq 84 4 for for IN cord-280130-ewqe9edq 84 5 the the DT cord-280130-ewqe9edq 84 6 targeted target VBN cord-280130-ewqe9edq 84 7 destruction destruction NN cord-280130-ewqe9edq 84 8 of of IN cord-280130-ewqe9edq 84 9 tumors tumor NNS cord-280130-ewqe9edq 84 10 is be VBZ cord-280130-ewqe9edq 84 11 another another DT cord-280130-ewqe9edq 84 12 promising promising JJ cord-280130-ewqe9edq 84 13 application application NN cord-280130-ewqe9edq 84 14 . . . cord-280130-ewqe9edq 85 1 Tumor tumor NN cord-280130-ewqe9edq 85 2 cells cell NNS cord-280130-ewqe9edq 85 3 often often RB cord-280130-ewqe9edq 85 4 eliminate eliminate VBP cord-280130-ewqe9edq 85 5 one one CD cord-280130-ewqe9edq 85 6 or or CC cord-280130-ewqe9edq 85 7 several several JJ cord-280130-ewqe9edq 85 8 parts part NNS cord-280130-ewqe9edq 85 9 of of IN cord-280130-ewqe9edq 85 10 the the DT cord-280130-ewqe9edq 85 11 IFN IFN NNP cord-280130-ewqe9edq 85 12 system system NN cord-280130-ewqe9edq 85 13 during during IN cord-280130-ewqe9edq 85 14 the the DT cord-280130-ewqe9edq 85 15 transformation transformation NN cord-280130-ewqe9edq 85 16 process process NN cord-280130-ewqe9edq 85 17 [ [ -LRB- cord-280130-ewqe9edq 85 18 130e133 130e133 CD cord-280130-ewqe9edq 85 19 ] ] -RRB- cord-280130-ewqe9edq 85 20 . . . cord-280130-ewqe9edq 86 1 For for IN cord-280130-ewqe9edq 86 2 example example NN cord-280130-ewqe9edq 86 3 , , , cord-280130-ewqe9edq 86 4 tumor tumor NN cord-280130-ewqe9edq 86 5 cells cell NNS cord-280130-ewqe9edq 86 6 were be VBD cord-280130-ewqe9edq 86 7 shown show VBN cord-280130-ewqe9edq 86 8 to to TO cord-280130-ewqe9edq 86 9 acquire acquire VB cord-280130-ewqe9edq 86 10 specific specific JJ cord-280130-ewqe9edq 86 11 mutations mutation NNS cord-280130-ewqe9edq 86 12 leading lead VBG cord-280130-ewqe9edq 86 13 to to IN cord-280130-ewqe9edq 86 14 resistance resistance NN cord-280130-ewqe9edq 86 15 of of IN cord-280130-ewqe9edq 86 16 cellular cellular JJ cord-280130-ewqe9edq 86 17 translation translation NN cord-280130-ewqe9edq 86 18 to to IN cord-280130-ewqe9edq 86 19 inhibition inhibition NN cord-280130-ewqe9edq 86 20 by by IN cord-280130-ewqe9edq 86 21 PKR PKR NNP cord-280130-ewqe9edq 86 22 [ [ -LRB- cord-280130-ewqe9edq 86 23 134 134 CD cord-280130-ewqe9edq 86 24 ] ] -RRB- cord-280130-ewqe9edq 86 25 . . . cord-280130-ewqe9edq 87 1 The the DT cord-280130-ewqe9edq 87 2 payoff payoff NN cord-280130-ewqe9edq 87 3 is be VBZ cord-280130-ewqe9edq 87 4 an an DT cord-280130-ewqe9edq 87 5 increased increase VBN cord-280130-ewqe9edq 87 6 susceptibility susceptibility NN cord-280130-ewqe9edq 87 7 to to IN cord-280130-ewqe9edq 87 8 infection infection NN cord-280130-ewqe9edq 87 9 [ [ -LRB- cord-280130-ewqe9edq 87 10 131 131 CD cord-280130-ewqe9edq 87 11 , , , cord-280130-ewqe9edq 87 12 134 134 CD cord-280130-ewqe9edq 87 13 , , , cord-280130-ewqe9edq 87 14 135 135 CD cord-280130-ewqe9edq 87 15 ] ] -RRB- cord-280130-ewqe9edq 87 16 , , , cord-280130-ewqe9edq 87 17 and and CC cord-280130-ewqe9edq 87 18 the the DT cord-280130-ewqe9edq 87 19 tumor tumor NN cord-280130-ewqe9edq 87 20 selectivity selectivity NN cord-280130-ewqe9edq 87 21 of of IN cord-280130-ewqe9edq 87 22 viruses virus NNS cord-280130-ewqe9edq 87 23 can can MD cord-280130-ewqe9edq 87 24 be be VB cord-280130-ewqe9edq 87 25 further further RB cord-280130-ewqe9edq 87 26 increased increase VBN cord-280130-ewqe9edq 87 27 by by IN cord-280130-ewqe9edq 87 28 using use VBG cord-280130-ewqe9edq 87 29 mutants mutant NNS cord-280130-ewqe9edq 87 30 with with IN cord-280130-ewqe9edq 87 31 defective defective JJ cord-280130-ewqe9edq 87 32 IFN IFN NNP cord-280130-ewqe9edq 87 33 antagonists antagonist NNS cord-280130-ewqe9edq 87 34 . . . cord-280130-ewqe9edq 88 1 The the DT cord-280130-ewqe9edq 88 2 inability inability NN cord-280130-ewqe9edq 88 3 of of IN cord-280130-ewqe9edq 88 4 these these DT cord-280130-ewqe9edq 88 5 mutant mutant JJ cord-280130-ewqe9edq 88 6 viruses virus NNS cord-280130-ewqe9edq 88 7 to to TO cord-280130-ewqe9edq 88 8 fight fight VB cord-280130-ewqe9edq 88 9 the the DT cord-280130-ewqe9edq 88 10 IFN IFN NNP cord-280130-ewqe9edq 88 11 response response NN cord-280130-ewqe9edq 88 12 is be VBZ cord-280130-ewqe9edq 88 13 complemented complement VBN cord-280130-ewqe9edq 88 14 by by IN cord-280130-ewqe9edq 88 15 the the DT cord-280130-ewqe9edq 88 16 IFN IFN NNP cord-280130-ewqe9edq 88 17 - - HYPH cord-280130-ewqe9edq 88 18 deficiency deficiency NN cord-280130-ewqe9edq 88 19 of of IN cord-280130-ewqe9edq 88 20 the the DT cord-280130-ewqe9edq 88 21 tumor tumor NN cord-280130-ewqe9edq 88 22 cells cell NNS cord-280130-ewqe9edq 88 23 . . . cord-280130-ewqe9edq 89 1 At at IN cord-280130-ewqe9edq 89 2 the the DT cord-280130-ewqe9edq 89 3 same same JJ cord-280130-ewqe9edq 89 4 time time NN cord-280130-ewqe9edq 89 5 , , , cord-280130-ewqe9edq 89 6 these these DT cord-280130-ewqe9edq 89 7 viruses virus NNS cord-280130-ewqe9edq 89 8 are be VBP cord-280130-ewqe9edq 89 9 unable unable JJ cord-280130-ewqe9edq 89 10 to to TO cord-280130-ewqe9edq 89 11 infect infect VB cord-280130-ewqe9edq 89 12 the the DT cord-280130-ewqe9edq 89 13 IFN IFN NNP cord-280130-ewqe9edq 89 14 - - HYPH cord-280130-ewqe9edq 89 15 competent competent JJ cord-280130-ewqe9edq 89 16 body body NN cord-280130-ewqe9edq 89 17 cells cell NNS cord-280130-ewqe9edq 89 18 . . . cord-280130-ewqe9edq 90 1 This this DT cord-280130-ewqe9edq 90 2 concept concept NN cord-280130-ewqe9edq 90 3 is be VBZ cord-280130-ewqe9edq 90 4 proven prove VBN cord-280130-ewqe9edq 90 5 by by IN cord-280130-ewqe9edq 90 6 an an DT cord-280130-ewqe9edq 90 7 IFN IFN NNP cord-280130-ewqe9edq 90 8 - - HYPH cord-280130-ewqe9edq 90 9 inducing induce VBG cord-280130-ewqe9edq 90 10 VSV VSV NNP cord-280130-ewqe9edq 90 11 mutant mutant NN cord-280130-ewqe9edq 90 12 [ [ -LRB- cord-280130-ewqe9edq 90 13 55 55 CD cord-280130-ewqe9edq 90 14 ] ] -RRB- cord-280130-ewqe9edq 90 15 and and CC cord-280130-ewqe9edq 90 16 a a DT cord-280130-ewqe9edq 90 17 herpes herpes NN cord-280130-ewqe9edq 90 18 simplex simplex NN cord-280130-ewqe9edq 90 19 virus virus NN cord-280130-ewqe9edq 90 20 lacking lack VBG cord-280130-ewqe9edq 90 21 the the DT cord-280130-ewqe9edq 90 22 anti anti NNP cord-280130-ewqe9edq 90 23 - - JJ cord-280130-ewqe9edq 90 24 PKR PKR NNP cord-280130-ewqe9edq 90 25 gene gene NN cord-280130-ewqe9edq 90 26 g34.5 g34.5 ADD cord-280130-ewqe9edq 90 27 [ [ -LRB- cord-280130-ewqe9edq 90 28 136 136 CD cord-280130-ewqe9edq 90 29 , , , cord-280130-ewqe9edq 90 30 137 137 CD cord-280130-ewqe9edq 90 31 ] ] -RRB- cord-280130-ewqe9edq 90 32 which which WDT cord-280130-ewqe9edq 90 33 specifically specifically RB cord-280130-ewqe9edq 90 34 destroyed destroy VBD cord-280130-ewqe9edq 90 35 tumors tumor NNS cord-280130-ewqe9edq 90 36 in in IN cord-280130-ewqe9edq 90 37 immunocompetent immunocompetent JJ cord-280130-ewqe9edq 90 38 hosts host NNS cord-280130-ewqe9edq 90 39 . . . cord-280130-ewqe9edq 91 1 Thus thus RB cord-280130-ewqe9edq 91 2 , , , cord-280130-ewqe9edq 91 3 unravelling unravel VBG cord-280130-ewqe9edq 91 4 the the DT cord-280130-ewqe9edq 91 5 strategies strategy NNS cord-280130-ewqe9edq 91 6 by by IN cord-280130-ewqe9edq 91 7 which which WDT cord-280130-ewqe9edq 91 8 viruses virus NNS cord-280130-ewqe9edq 91 9 counteract counteract VBP cord-280130-ewqe9edq 91 10 the the DT cord-280130-ewqe9edq 91 11 IFN IFN NNP cord-280130-ewqe9edq 91 12 system system NN cord-280130-ewqe9edq 91 13 not not RB cord-280130-ewqe9edq 91 14 only only RB cord-280130-ewqe9edq 91 15 helps help VBZ cord-280130-ewqe9edq 91 16 to to TO cord-280130-ewqe9edq 91 17 better well RBR cord-280130-ewqe9edq 91 18 understand understand VB cord-280130-ewqe9edq 91 19 viral viral JJ cord-280130-ewqe9edq 91 20 pathogenesis pathogenesis NN cord-280130-ewqe9edq 91 21 but but CC cord-280130-ewqe9edq 91 22 can can MD cord-280130-ewqe9edq 91 23 also also RB cord-280130-ewqe9edq 91 24 result result VB cord-280130-ewqe9edq 91 25 in in IN cord-280130-ewqe9edq 91 26 novel novel JJ cord-280130-ewqe9edq 91 27 vaccination vaccination NN cord-280130-ewqe9edq 91 28 strategies strategy NNS cord-280130-ewqe9edq 91 29 and and CC cord-280130-ewqe9edq 91 30 therapies therapy NNS cord-280130-ewqe9edq 91 31 . . . cord-280130-ewqe9edq 92 1 Virus virus NN cord-280130-ewqe9edq 92 2 interference interference NN cord-280130-ewqe9edq 92 3 . . . cord-280130-ewqe9edq 93 1 I. I. NNP cord-280130-ewqe9edq 93 2 , , , cord-280130-ewqe9edq 93 3 The the DT cord-280130-ewqe9edq 93 4 interferon interferon NN cord-280130-ewqe9edq 93 5 Viruses virus NNS cord-280130-ewqe9edq 93 6 and and CC cord-280130-ewqe9edq 93 7 the the DT cord-280130-ewqe9edq 93 8 type type NN cord-280130-ewqe9edq 94 1 I -PRON- PRP cord-280130-ewqe9edq 94 2 interferon interferon VBP cord-280130-ewqe9edq 94 3 antiviral antiviral JJ cord-280130-ewqe9edq 94 4 system system NN cord-280130-ewqe9edq 94 5 : : : cord-280130-ewqe9edq 95 1 induction induction NN cord-280130-ewqe9edq 95 2 and and CC cord-280130-ewqe9edq 95 3 evasion evasion NN cord-280130-ewqe9edq 95 4 Transcriptional Transcriptional NNP cord-280130-ewqe9edq 95 5 activation activation NN cord-280130-ewqe9edq 95 6 of of IN cord-280130-ewqe9edq 95 7 alpha alpha NN cord-280130-ewqe9edq 95 8 / / SYM cord-280130-ewqe9edq 95 9 beta beta NN cord-280130-ewqe9edq 95 10 interferon interferon NN cord-280130-ewqe9edq 95 11 genes gene NNS cord-280130-ewqe9edq 95 12 : : : cord-280130-ewqe9edq 95 13 interference interference NN cord-280130-ewqe9edq 95 14 by by IN cord-280130-ewqe9edq 95 15 nonsegmented nonsegmente VBN cord-280130-ewqe9edq 95 16 negative negative JJ cord-280130-ewqe9edq 95 17 - - HYPH cord-280130-ewqe9edq 95 18 strand strand NN cord-280130-ewqe9edq 95 19 RNA RNA NNP cord-280130-ewqe9edq 95 20 viruses virus NNS cord-280130-ewqe9edq 96 1 Type type NN cord-280130-ewqe9edq 96 2 1 1 CD cord-280130-ewqe9edq 96 3 interferons interferon NNS cord-280130-ewqe9edq 96 4 and and CC cord-280130-ewqe9edq 96 5 the the DT cord-280130-ewqe9edq 96 6 virus virus NN cord-280130-ewqe9edq 96 7 - - HYPH cord-280130-ewqe9edq 96 8 host host NN cord-280130-ewqe9edq 96 9 relationship relationship NN cord-280130-ewqe9edq 96 10 : : : cord-280130-ewqe9edq 96 11 a a DT cord-280130-ewqe9edq 96 12 lesson lesson NN cord-280130-ewqe9edq 96 13 in in IN cord-280130-ewqe9edq 96 14 detente detente NN cord-280130-ewqe9edq 97 1 The the DT cord-280130-ewqe9edq 97 2 interferon interferon NN cord-280130-ewqe9edq 97 3 response response NN cord-280130-ewqe9edq 97 4 circuit circuit NN cord-280130-ewqe9edq 97 5 : : : cord-280130-ewqe9edq 98 1 Induction induction NN cord-280130-ewqe9edq 98 2 and and CC cord-280130-ewqe9edq 98 3 suppression suppression NN cord-280130-ewqe9edq 98 4 by by IN cord-280130-ewqe9edq 98 5 pathogenic pathogenic JJ cord-280130-ewqe9edq 98 6 viruses virus NNS cord-280130-ewqe9edq 99 1 Inverse inverse JJ cord-280130-ewqe9edq 99 2 interference interference NN cord-280130-ewqe9edq 99 3 : : : cord-280130-ewqe9edq 99 4 how how WRB cord-280130-ewqe9edq 99 5 viruses virus NNS cord-280130-ewqe9edq 99 6 fight fight VBP cord-280130-ewqe9edq 99 7 the the DT cord-280130-ewqe9edq 99 8 interferon interferon NN cord-280130-ewqe9edq 99 9 system system NN cord-280130-ewqe9edq 99 10 Inhibition Inhibition NNP cord-280130-ewqe9edq 99 11 of of IN cord-280130-ewqe9edq 99 12 PKR PKR NNP cord-280130-ewqe9edq 99 13 by by IN cord-280130-ewqe9edq 99 14 RNA RNA NNP cord-280130-ewqe9edq 99 15 and and CC cord-280130-ewqe9edq 99 16 DNA dna NN cord-280130-ewqe9edq 99 17 viruses virus NNS cord-280130-ewqe9edq 99 18 Characterization characterization NN cord-280130-ewqe9edq 99 19 of of IN cord-280130-ewqe9edq 99 20 viral viral JJ cord-280130-ewqe9edq 99 21 doublestranded doublestranded NNP cord-280130-ewqe9edq 99 22 RNA RNA NNP cord-280130-ewqe9edq 99 23 - - HYPH cord-280130-ewqe9edq 99 24 binding bind VBG cord-280130-ewqe9edq 99 25 proteins protein NNS cord-280130-ewqe9edq 100 1 Influenza Influenza NNP cord-280130-ewqe9edq 100 2 A a DT cord-280130-ewqe9edq 100 3 virus virus NN cord-280130-ewqe9edq 100 4 lacking lack VBG cord-280130-ewqe9edq 101 1 the the DT cord-280130-ewqe9edq 101 2 NS1 NS1 NNP cord-280130-ewqe9edq 101 3 gene gene NN cord-280130-ewqe9edq 101 4 replicates replicate NNS cord-280130-ewqe9edq 101 5 in in IN cord-280130-ewqe9edq 101 6 interferon interferon NN cord-280130-ewqe9edq 101 7 - - HYPH cord-280130-ewqe9edq 101 8 deficient deficient JJ cord-280130-ewqe9edq 101 9 systems system NNS cord-280130-ewqe9edq 101 10 Inhibition inhibition NN cord-280130-ewqe9edq 101 11 of of IN cord-280130-ewqe9edq 101 12 interferon interferon NN cord-280130-ewqe9edq 101 13 - - HYPH cord-280130-ewqe9edq 101 14 mediated mediate VBN cord-280130-ewqe9edq 101 15 antiviral antiviral JJ cord-280130-ewqe9edq 101 16 responses response NNS cord-280130-ewqe9edq 101 17 by by IN cord-280130-ewqe9edq 101 18 Influenza Influenza NNP cord-280130-ewqe9edq 101 19 A A NNP cord-280130-ewqe9edq 101 20 viruses virus NNS cord-280130-ewqe9edq 101 21 and and CC cord-280130-ewqe9edq 101 22 other other JJ cord-280130-ewqe9edq 101 23 negative negative JJ cord-280130-ewqe9edq 101 24 - - HYPH cord-280130-ewqe9edq 101 25 strand strand NN cord-280130-ewqe9edq 101 26 RNA RNA NNP cord-280130-ewqe9edq 101 27 viruses virus NNS cord-280130-ewqe9edq 101 28 Binding bind VBG cord-280130-ewqe9edq 101 29 of of IN cord-280130-ewqe9edq 101 30 the the DT cord-280130-ewqe9edq 101 31 influenza influenza NN cord-280130-ewqe9edq 101 32 virus virus NN cord-280130-ewqe9edq 101 33 NS1 ns1 CD cord-280130-ewqe9edq 101 34 protein protein NN cord-280130-ewqe9edq 101 35 to to IN cord-280130-ewqe9edq 101 36 double double RB cord-280130-ewqe9edq 101 37 - - HYPH cord-280130-ewqe9edq 101 38 stranded strand VBN cord-280130-ewqe9edq 101 39 RNA RNA NNP cord-280130-ewqe9edq 101 40 inhibits inhibit VBZ cord-280130-ewqe9edq 101 41 the the DT cord-280130-ewqe9edq 101 42 activation activation NN cord-280130-ewqe9edq 101 43 of of IN cord-280130-ewqe9edq 101 44 the the DT cord-280130-ewqe9edq 101 45 protein protein NN cord-280130-ewqe9edq 101 46 kinase kinase NN cord-280130-ewqe9edq 101 47 that that WDT cord-280130-ewqe9edq 101 48 phosphorylates phosphorylate VBZ cord-280130-ewqe9edq 101 49 the the DT cord-280130-ewqe9edq 101 50 elF-2 elF-2 NNP cord-280130-ewqe9edq 101 51 translation translation NN cord-280130-ewqe9edq 101 52 initiation initiation NN cord-280130-ewqe9edq 101 53 factor factor NN cord-280130-ewqe9edq 101 54 The the DT cord-280130-ewqe9edq 101 55 primary primary JJ cord-280130-ewqe9edq 101 56 function function NN cord-280130-ewqe9edq 101 57 of of IN cord-280130-ewqe9edq 101 58 RNA RNA NNP cord-280130-ewqe9edq 101 59 binding bind VBG cord-280130-ewqe9edq 101 60 by by IN cord-280130-ewqe9edq 101 61 the the DT cord-280130-ewqe9edq 101 62 influenza influenza NN cord-280130-ewqe9edq 101 63 A a DT cord-280130-ewqe9edq 101 64 virus virus NN cord-280130-ewqe9edq 101 65 NS1 ns1 CD cord-280130-ewqe9edq 101 66 protein protein NN cord-280130-ewqe9edq 101 67 in in IN cord-280130-ewqe9edq 101 68 infected infected JJ cord-280130-ewqe9edq 101 69 cells cell NNS cord-280130-ewqe9edq 101 70 : : : cord-280130-ewqe9edq 101 71 Inhibiting inhibit VBG cord-280130-ewqe9edq 101 72 the the DT cord-280130-ewqe9edq 101 73 2 2 CD cord-280130-ewqe9edq 101 74 0 0 CD cord-280130-ewqe9edq 101 75 -5 -5 CD cord-280130-ewqe9edq 101 76 0 0 CD cord-280130-ewqe9edq 101 77 oligo oligo NN cord-280130-ewqe9edq 101 78 ( ( -LRB- cord-280130-ewqe9edq 101 79 A a NN cord-280130-ewqe9edq 101 80 ) ) -RRB- cord-280130-ewqe9edq 101 81 synthetase synthetase NN cord-280130-ewqe9edq 101 82 / / SYM cord-280130-ewqe9edq 101 83 RNase rnase NN cord-280130-ewqe9edq 101 84 L L NNP cord-280130-ewqe9edq 101 85 pathway pathway NN cord-280130-ewqe9edq 101 86 Replication replication NN cord-280130-ewqe9edq 101 87 of of IN cord-280130-ewqe9edq 101 88 modified modify VBN cord-280130-ewqe9edq 101 89 vaccinia vaccinia NN cord-280130-ewqe9edq 101 90 virus virus NN cord-280130-ewqe9edq 101 91 Ankara Ankara NNP cord-280130-ewqe9edq 101 92 in in IN cord-280130-ewqe9edq 101 93 primary primary JJ cord-280130-ewqe9edq 101 94 chicken chicken NN cord-280130-ewqe9edq 101 95 embryo embryo NN cord-280130-ewqe9edq 101 96 fibroblasts fibroblast NNS cord-280130-ewqe9edq 101 97 requires require VBZ cord-280130-ewqe9edq 101 98 expression expression NN cord-280130-ewqe9edq 101 99 of of IN cord-280130-ewqe9edq 101 100 the the DT cord-280130-ewqe9edq 101 101 interferon interferon NNP cord-280130-ewqe9edq 101 102 resistance resistance NN cord-280130-ewqe9edq 101 103 gene gene NN cord-280130-ewqe9edq 101 104 E3L e3l NN cord-280130-ewqe9edq 101 105 Blockade Blockade NNP cord-280130-ewqe9edq 101 106 of of IN cord-280130-ewqe9edq 101 107 interferon interferon NN cord-280130-ewqe9edq 101 108 induction induction NN cord-280130-ewqe9edq 101 109 and and CC cord-280130-ewqe9edq 101 110 action action NN cord-280130-ewqe9edq 101 111 by by IN cord-280130-ewqe9edq 101 112 the the DT cord-280130-ewqe9edq 101 113 E3L e3l NN cord-280130-ewqe9edq 101 114 double double RB cord-280130-ewqe9edq 101 115 - - HYPH cord-280130-ewqe9edq 101 116 stranded strand VBN cord-280130-ewqe9edq 101 117 RNA RNA NNP cord-280130-ewqe9edq 101 118 binding bind VBG cord-280130-ewqe9edq 101 119 proteins protein NNS cord-280130-ewqe9edq 101 120 of of IN cord-280130-ewqe9edq 101 121 vaccinia vaccinia NN cord-280130-ewqe9edq 101 122 virus virus NN cord-280130-ewqe9edq 101 123 Ebola Ebola NNP cord-280130-ewqe9edq 101 124 virus virus NN cord-280130-ewqe9edq 101 125 VP35 VP35 NNP cord-280130-ewqe9edq 101 126 protein protein NN cord-280130-ewqe9edq 101 127 binds bind VBZ cord-280130-ewqe9edq 101 128 double double RB cord-280130-ewqe9edq 101 129 - - HYPH cord-280130-ewqe9edq 101 130 stranded strand VBN cord-280130-ewqe9edq 101 131 RNA RNA NNP cord-280130-ewqe9edq 101 132 and and CC cord-280130-ewqe9edq 101 133 inhibits inhibit VBZ cord-280130-ewqe9edq 101 134 alpha alpha NN cord-280130-ewqe9edq 101 135 / / SYM cord-280130-ewqe9edq 101 136 beta beta NN cord-280130-ewqe9edq 101 137 interferon interferon NN cord-280130-ewqe9edq 101 138 production production NN cord-280130-ewqe9edq 101 139 induced induce VBN cord-280130-ewqe9edq 101 140 by by IN cord-280130-ewqe9edq 101 141 RIG rig NN cord-280130-ewqe9edq 102 1 -I -i DT cord-280130-ewqe9edq 102 2 signaling signal VBG cord-280130-ewqe9edq 102 3 Reverse reverse JJ cord-280130-ewqe9edq 102 4 genetic genetic JJ cord-280130-ewqe9edq 102 5 generation generation NN cord-280130-ewqe9edq 102 6 of of IN cord-280130-ewqe9edq 102 7 recombinant recombinant JJ cord-280130-ewqe9edq 102 8 Zaire Zaire NNP cord-280130-ewqe9edq 102 9 Ebola Ebola NNP cord-280130-ewqe9edq 102 10 viruses virus NNS cord-280130-ewqe9edq 102 11 containing contain VBG cord-280130-ewqe9edq 102 12 disrupted disrupt VBD cord-280130-ewqe9edq 102 13 IRF-3 IRF-3 NNP cord-280130-ewqe9edq 102 14 inhibitory inhibitory JJ cord-280130-ewqe9edq 102 15 domains domain NNS cord-280130-ewqe9edq 102 16 results result NNS cord-280130-ewqe9edq 102 17 in in IN cord-280130-ewqe9edq 102 18 attenuated attenuated JJ cord-280130-ewqe9edq 102 19 virus virus NN cord-280130-ewqe9edq 102 20 growth growth NN cord-280130-ewqe9edq 102 21 in in IN cord-280130-ewqe9edq 102 22 vitro vitro FW cord-280130-ewqe9edq 102 23 and and CC cord-280130-ewqe9edq 102 24 higher high JJR cord-280130-ewqe9edq 102 25 levels level NNS cord-280130-ewqe9edq 102 26 of of IN cord-280130-ewqe9edq 102 27 IRF-3 IRF-3 NNP cord-280130-ewqe9edq 102 28 activation activation NN cord-280130-ewqe9edq 102 29 without without IN cord-280130-ewqe9edq 102 30 inhibiting inhibit VBG cord-280130-ewqe9edq 102 31 viral viral JJ cord-280130-ewqe9edq 102 32 transcription transcription NN cord-280130-ewqe9edq 102 33 or or CC cord-280130-ewqe9edq 102 34 replication replication NN cord-280130-ewqe9edq 102 35 Reovirus Reovirus NNP cord-280130-ewqe9edq 102 36 sigma sigma NN cord-280130-ewqe9edq 102 37 3 3 CD cord-280130-ewqe9edq 102 38 protein protein NN cord-280130-ewqe9edq 102 39 : : : cord-280130-ewqe9edq 102 40 dsRNA dsRNA . cord-280130-ewqe9edq 103 1 binding bind VBG cord-280130-ewqe9edq 103 2 and and CC cord-280130-ewqe9edq 103 3 inhibition inhibition NN cord-280130-ewqe9edq 103 4 of of IN cord-280130-ewqe9edq 103 5 RNA RNA NNP cord-280130-ewqe9edq 103 6 - - HYPH cord-280130-ewqe9edq 103 7 activated activate VBN cord-280130-ewqe9edq 103 8 protein protein NN cord-280130-ewqe9edq 103 9 kinase kinase NN cord-280130-ewqe9edq 103 10 Neutralizing neutralize VBG cord-280130-ewqe9edq 103 11 innate innate JJ cord-280130-ewqe9edq 103 12 host host NN cord-280130-ewqe9edq 103 13 defenses defense NNS cord-280130-ewqe9edq 103 14 to to TO cord-280130-ewqe9edq 103 15 control control VB cord-280130-ewqe9edq 103 16 viral viral JJ cord-280130-ewqe9edq 103 17 translation translation NN cord-280130-ewqe9edq 103 18 in in IN cord-280130-ewqe9edq 103 19 HSV-1 HSV-1 NNP cord-280130-ewqe9edq 103 20 infected infect VBN cord-280130-ewqe9edq 103 21 cells cell NNS cord-280130-ewqe9edq 103 22 Inhibition inhibition NN cord-280130-ewqe9edq 103 23 of of IN cord-280130-ewqe9edq 103 24 PKR PKR NNP cord-280130-ewqe9edq 104 1 activation activation NN cord-280130-ewqe9edq 104 2 by by IN cord-280130-ewqe9edq 104 3 the the DT cord-280130-ewqe9edq 104 4 proline proline JJ cord-280130-ewqe9edq 104 5 - - HYPH cord-280130-ewqe9edq 104 6 rich rich JJ cord-280130-ewqe9edq 104 7 RNA RNA NNP cord-280130-ewqe9edq 104 8 binding binding NN cord-280130-ewqe9edq 104 9 domain domain NN cord-280130-ewqe9edq 104 10 of of IN cord-280130-ewqe9edq 104 11 the the DT cord-280130-ewqe9edq 104 12 herpes herpes NNP cord-280130-ewqe9edq 104 13 simplex simplex NNP cord-280130-ewqe9edq 104 14 virus virus NN cord-280130-ewqe9edq 104 15 type type NN cord-280130-ewqe9edq 104 16 1 1 CD cord-280130-ewqe9edq 104 17 Us11 Us11 NNP cord-280130-ewqe9edq 104 18 protein protein NN cord-280130-ewqe9edq 104 19 Double Double NNP cord-280130-ewqe9edq 104 20 - - HYPH cord-280130-ewqe9edq 104 21 stranded strand VBN cord-280130-ewqe9edq 104 22 RNA RNA NNP cord-280130-ewqe9edq 104 23 binding bind VBG cord-280130-ewqe9edq 104 24 by by IN cord-280130-ewqe9edq 104 25 a a DT cord-280130-ewqe9edq 104 26 heterodimeric heterodimeric JJ cord-280130-ewqe9edq 104 27 complex complex NN cord-280130-ewqe9edq 104 28 of of IN cord-280130-ewqe9edq 104 29 murine murine JJ cord-280130-ewqe9edq 104 30 cytomegalovirus cytomegalovirus NNP cord-280130-ewqe9edq 104 31 m142 m142 NN cord-280130-ewqe9edq 104 32 and and CC cord-280130-ewqe9edq 104 33 m143 m143 JJ cord-280130-ewqe9edq 104 34 proteins protein NNS cord-280130-ewqe9edq 104 35 Murine murine JJ cord-280130-ewqe9edq 104 36 cytomegalovirus cytomegalovirus JJ cord-280130-ewqe9edq 104 37 m142 m142 NNS cord-280130-ewqe9edq 104 38 and and CC cord-280130-ewqe9edq 104 39 m143 m143 NNS cord-280130-ewqe9edq 104 40 are be VBP cord-280130-ewqe9edq 104 41 both both DT cord-280130-ewqe9edq 104 42 required require VBN cord-280130-ewqe9edq 104 43 to to TO cord-280130-ewqe9edq 104 44 block block VB cord-280130-ewqe9edq 104 45 protein protein NN cord-280130-ewqe9edq 104 46 kinase kinase NN cord-280130-ewqe9edq 104 47 R r NN cord-280130-ewqe9edq 104 48 - - HYPH cord-280130-ewqe9edq 104 49 mediated mediate VBN cord-280130-ewqe9edq 104 50 shutdown shutdown NN cord-280130-ewqe9edq 104 51 of of IN cord-280130-ewqe9edq 104 52 protein protein NN cord-280130-ewqe9edq 104 53 synthesis synthesis NN cord-280130-ewqe9edq 105 1 The the DT cord-280130-ewqe9edq 105 2 N N NNP cord-280130-ewqe9edq 105 3 - - HYPH cord-280130-ewqe9edq 105 4 and and CC cord-280130-ewqe9edq 105 5 C c NN cord-280130-ewqe9edq 105 6 - - HYPH cord-280130-ewqe9edq 105 7 terminal terminal NN cord-280130-ewqe9edq 105 8 domains domain NNS cord-280130-ewqe9edq 105 9 of of IN cord-280130-ewqe9edq 105 10 the the DT cord-280130-ewqe9edq 105 11 NS1 ns1 NN cord-280130-ewqe9edq 105 12 protein protein NN cord-280130-ewqe9edq 105 13 of of IN cord-280130-ewqe9edq 105 14 influenza influenza NN cord-280130-ewqe9edq 105 15 B B NNP cord-280130-ewqe9edq 105 16 virus virus NN cord-280130-ewqe9edq 105 17 can can MD cord-280130-ewqe9edq 105 18 independently independently RB cord-280130-ewqe9edq 105 19 inhibit inhibit VB cord-280130-ewqe9edq 105 20 IRF-3 IRF-3 NNP cord-280130-ewqe9edq 105 21 and and CC cord-280130-ewqe9edq 105 22 beta beta NN cord-280130-ewqe9edq 105 23 interferon interferon NN cord-280130-ewqe9edq 105 24 promoter promoter NN cord-280130-ewqe9edq 105 25 activation activation NN cord-280130-ewqe9edq 105 26 A a DT cord-280130-ewqe9edq 105 27 recombinant recombinant JJ cord-280130-ewqe9edq 105 28 influenza influenza NN cord-280130-ewqe9edq 105 29 A a DT cord-280130-ewqe9edq 105 30 virus virus NN cord-280130-ewqe9edq 105 31 expressing express VBG cord-280130-ewqe9edq 105 32 an an DT cord-280130-ewqe9edq 105 33 RNA rna NN cord-280130-ewqe9edq 105 34 - - HYPH cord-280130-ewqe9edq 105 35 binding bind VBG cord-280130-ewqe9edq 105 36 - - HYPH cord-280130-ewqe9edq 105 37 defective defective JJ cord-280130-ewqe9edq 105 38 NS1 NS1 NNS cord-280130-ewqe9edq 105 39 protein protein NN cord-280130-ewqe9edq 105 40 induces induce VBZ cord-280130-ewqe9edq 105 41 high high JJ cord-280130-ewqe9edq 105 42 levels level NNS cord-280130-ewqe9edq 105 43 of of IN cord-280130-ewqe9edq 105 44 beta beta NN cord-280130-ewqe9edq 105 45 interferon interferon NN cord-280130-ewqe9edq 105 46 and and CC cord-280130-ewqe9edq 105 47 is be VBZ cord-280130-ewqe9edq 105 48 attenuated attenuate VBN cord-280130-ewqe9edq 105 49 in in IN cord-280130-ewqe9edq 105 50 mice mouse NNS cord-280130-ewqe9edq 105 51 Double double RB cord-280130-ewqe9edq 105 52 - - HYPH cord-280130-ewqe9edq 105 53 stranded strand VBN cord-280130-ewqe9edq 105 54 RNA RNA NNP cord-280130-ewqe9edq 105 55 is be VBZ cord-280130-ewqe9edq 105 56 produced produce VBN cord-280130-ewqe9edq 105 57 by by IN cord-280130-ewqe9edq 105 58 positive positive JJ cord-280130-ewqe9edq 105 59 - - HYPH cord-280130-ewqe9edq 105 60 strand strand NN cord-280130-ewqe9edq 105 61 RNA RNA NNP cord-280130-ewqe9edq 105 62 viruses virus NNS cord-280130-ewqe9edq 105 63 and and CC cord-280130-ewqe9edq 105 64 DNA dna NN cord-280130-ewqe9edq 105 65 viruses virus NNS cord-280130-ewqe9edq 105 66 but but CC cord-280130-ewqe9edq 105 67 not not RB cord-280130-ewqe9edq 105 68 in in IN cord-280130-ewqe9edq 105 69 detectable detectable JJ cord-280130-ewqe9edq 105 70 amounts amount NNS cord-280130-ewqe9edq 105 71 by by IN cord-280130-ewqe9edq 105 72 negative negative JJ cord-280130-ewqe9edq 105 73 - - HYPH cord-280130-ewqe9edq 105 74 strand strand NN cord-280130-ewqe9edq 105 75 RNA RNA NNP cord-280130-ewqe9edq 105 76 viruses virus NNS cord-280130-ewqe9edq 105 77 0 0 NFP cord-280130-ewqe9edq 106 1 -Triphosphate -Triphosphate . cord-280130-ewqe9edq 107 1 RNA RNA NNP cord-280130-ewqe9edq 107 2 is be VBZ cord-280130-ewqe9edq 107 3 the the DT cord-280130-ewqe9edq 107 4 ligand ligand NN cord-280130-ewqe9edq 107 5 for for IN cord-280130-ewqe9edq 107 6 RIG rig NN cord-280130-ewqe9edq 107 7 - - : cord-280130-ewqe9edq 107 8 I I NNP cord-280130-ewqe9edq 107 9 RIG rig NN cord-280130-ewqe9edq 107 10 - - : cord-280130-ewqe9edq 107 11 I i NN cord-280130-ewqe9edq 107 12 - - HYPH cord-280130-ewqe9edq 107 13 mediated mediate VBN cord-280130-ewqe9edq 107 14 antiviral antiviral JJ cord-280130-ewqe9edq 107 15 responses response NNS cord-280130-ewqe9edq 107 16 to to IN cord-280130-ewqe9edq 107 17 single single RB cord-280130-ewqe9edq 107 18 - - HYPH cord-280130-ewqe9edq 107 19 stranded strand VBN cord-280130-ewqe9edq 107 20 RNA RNA NNP cord-280130-ewqe9edq 107 21 bearing bear VBG cord-280130-ewqe9edq 107 22 5 5 CD cord-280130-ewqe9edq 107 23 0 0 CD cord-280130-ewqe9edq 107 24 phosphates phosphate NNS cord-280130-ewqe9edq 107 25 Inhibition inhibition NN cord-280130-ewqe9edq 107 26 of of IN cord-280130-ewqe9edq 107 27 retinoic retinoic JJ cord-280130-ewqe9edq 107 28 acid acid NN cord-280130-ewqe9edq 107 29 - - HYPH cord-280130-ewqe9edq 107 30 inducible inducible JJ cord-280130-ewqe9edq 107 31 gene gene NN cord-280130-ewqe9edq 107 32 - - HYPH cord-280130-ewqe9edq 107 33 I i NN cord-280130-ewqe9edq 107 34 - - HYPH cord-280130-ewqe9edq 107 35 mediated mediate VBN cord-280130-ewqe9edq 107 36 induction induction NN cord-280130-ewqe9edq 107 37 of of IN cord-280130-ewqe9edq 107 38 interferon-{beta interferon-{beta NN cord-280130-ewqe9edq 107 39 } } -RRB- cord-280130-ewqe9edq 107 40 by by IN cord-280130-ewqe9edq 107 41 the the DT cord-280130-ewqe9edq 107 42 NS1 ns1 NN cord-280130-ewqe9edq 107 43 protein protein NN cord-280130-ewqe9edq 107 44 of of IN cord-280130-ewqe9edq 107 45 influenza influenza NN cord-280130-ewqe9edq 107 46 A a DT cord-280130-ewqe9edq 107 47 virus virus NN cord-280130-ewqe9edq 108 1 The the DT cord-280130-ewqe9edq 108 2 V v NN cord-280130-ewqe9edq 108 3 proteins protein NNS cord-280130-ewqe9edq 108 4 of of IN cord-280130-ewqe9edq 108 5 paramyxoviruses paramyxovirus NNS cord-280130-ewqe9edq 108 6 bind bind VBP cord-280130-ewqe9edq 108 7 the the DT cord-280130-ewqe9edq 108 8 IFN IFN NNP cord-280130-ewqe9edq 108 9 - - HYPH cord-280130-ewqe9edq 108 10 inducible inducible JJ cord-280130-ewqe9edq 108 11 RNA RNA NNP cord-280130-ewqe9edq 108 12 helicase helicase NN cord-280130-ewqe9edq 108 13 , , , cord-280130-ewqe9edq 108 14 mda-5 mda-5 NNP cord-280130-ewqe9edq 108 15 , , , cord-280130-ewqe9edq 108 16 and and CC cord-280130-ewqe9edq 108 17 inhibit inhibit VB cord-280130-ewqe9edq 108 18 its -PRON- PRP$ cord-280130-ewqe9edq 108 19 activation activation NN cord-280130-ewqe9edq 108 20 of of IN cord-280130-ewqe9edq 108 21 the the DT cord-280130-ewqe9edq 108 22 IFN IFN NNP cord-280130-ewqe9edq 108 23 - - HYPH cord-280130-ewqe9edq 108 24 beta beta NN cord-280130-ewqe9edq 108 25 promoter promoter NN cord-280130-ewqe9edq 108 26 mda-5 mda-5 NNP cord-280130-ewqe9edq 108 27 , , , cord-280130-ewqe9edq 108 28 but but CC cord-280130-ewqe9edq 109 1 not not RB cord-280130-ewqe9edq 109 2 RIG rig NN cord-280130-ewqe9edq 109 3 - - : cord-280130-ewqe9edq 109 4 I I NNP cord-280130-ewqe9edq 109 5 , , , cord-280130-ewqe9edq 109 6 is be VBZ cord-280130-ewqe9edq 109 7 a a DT cord-280130-ewqe9edq 109 8 common common JJ cord-280130-ewqe9edq 109 9 target target NN cord-280130-ewqe9edq 109 10 for for IN cord-280130-ewqe9edq 109 11 paramyxovirus paramyxovirus JJ cord-280130-ewqe9edq 109 12 V V NNP cord-280130-ewqe9edq 109 13 proteins protein NNS cord-280130-ewqe9edq 109 14 Dissociation Dissociation NNP cord-280130-ewqe9edq 109 15 of of IN cord-280130-ewqe9edq 109 16 a a DT cord-280130-ewqe9edq 109 17 MAVS/ MAVS/ NNP cord-280130-ewqe9edq 109 18 IPS-1 IPS-1 NNP cord-280130-ewqe9edq 109 19 / / SYM cord-280130-ewqe9edq 109 20 VISA VISA NNP cord-280130-ewqe9edq 109 21 / / SYM cord-280130-ewqe9edq 109 22 Cardif Cardif NNP cord-280130-ewqe9edq 109 23 - - HYPH cord-280130-ewqe9edq 109 24 IKKepsilon IKKepsilon NNP cord-280130-ewqe9edq 109 25 molecular molecular JJ cord-280130-ewqe9edq 109 26 complex complex NN cord-280130-ewqe9edq 109 27 from from IN cord-280130-ewqe9edq 109 28 the the DT cord-280130-ewqe9edq 109 29 mitochondrial mitochondrial JJ cord-280130-ewqe9edq 109 30 outer outer JJ cord-280130-ewqe9edq 109 31 membrane membrane NN cord-280130-ewqe9edq 109 32 by by IN cord-280130-ewqe9edq 109 33 hepatitis hepatitis NN cord-280130-ewqe9edq 109 34 C C NNP cord-280130-ewqe9edq 109 35 virus virus NN cord-280130-ewqe9edq 110 1 NS3 ns3 RB cord-280130-ewqe9edq 110 2 - - HYPH cord-280130-ewqe9edq 110 3 4A 4a CD cord-280130-ewqe9edq 110 4 proteolytic proteolytic JJ cord-280130-ewqe9edq 110 5 cleavage cleavage NN cord-280130-ewqe9edq 110 6 Cardif Cardif NNP cord-280130-ewqe9edq 110 7 is be VBZ cord-280130-ewqe9edq 110 8 an an DT cord-280130-ewqe9edq 110 9 adaptor adaptor NN cord-280130-ewqe9edq 110 10 protein protein NN cord-280130-ewqe9edq 110 11 in in IN cord-280130-ewqe9edq 110 12 the the DT cord-280130-ewqe9edq 110 13 RIG rig NN cord-280130-ewqe9edq 110 14 - - : cord-280130-ewqe9edq 110 15 I I NNP cord-280130-ewqe9edq 110 16 antiviral antiviral JJ cord-280130-ewqe9edq 110 17 pathway pathway NN cord-280130-ewqe9edq 110 18 and and CC cord-280130-ewqe9edq 110 19 is be VBZ cord-280130-ewqe9edq 110 20 targeted target VBN cord-280130-ewqe9edq 110 21 by by IN cord-280130-ewqe9edq 110 22 hepatitis hepatitis NN cord-280130-ewqe9edq 110 23 C C NNP cord-280130-ewqe9edq 110 24 virus virus NN cord-280130-ewqe9edq 110 25 Identification identification NN cord-280130-ewqe9edq 110 26 of of IN cord-280130-ewqe9edq 110 27 the the DT cord-280130-ewqe9edq 110 28 rabies rabies NN cord-280130-ewqe9edq 110 29 virus virus NN cord-280130-ewqe9edq 111 1 alpha alpha NN cord-280130-ewqe9edq 111 2 / / SYM cord-280130-ewqe9edq 111 3 beta beta JJ cord-280130-ewqe9edq 111 4 interferon interferon NN cord-280130-ewqe9edq 111 5 antagonist antagonist NN cord-280130-ewqe9edq 111 6 : : : cord-280130-ewqe9edq 112 1 phosphoprotein phosphoprotein NNP cord-280130-ewqe9edq 112 2 P p NN cord-280130-ewqe9edq 112 3 interferes interfere VBZ cord-280130-ewqe9edq 112 4 with with IN cord-280130-ewqe9edq 112 5 phosphorylation phosphorylation NN cord-280130-ewqe9edq 112 6 of of IN cord-280130-ewqe9edq 112 7 interferon interferon NN cord-280130-ewqe9edq 112 8 regulatory regulatory JJ cord-280130-ewqe9edq 112 9 factor factor NN cord-280130-ewqe9edq 112 10 3 3 CD cord-280130-ewqe9edq 113 1 The the DT cord-280130-ewqe9edq 113 2 pathogenic pathogenic JJ cord-280130-ewqe9edq 113 3 NY-1 NY-1 NNP cord-280130-ewqe9edq 113 4 hantavirus hantavirus NN cord-280130-ewqe9edq 113 5 G1 G1 NNP cord-280130-ewqe9edq 113 6 cytoplasmic cytoplasmic JJ cord-280130-ewqe9edq 113 7 tail tail NN cord-280130-ewqe9edq 113 8 inhibits inhibit VBZ cord-280130-ewqe9edq 113 9 RIG rig NN cord-280130-ewqe9edq 113 10 - - HYPH cord-280130-ewqe9edq 113 11 I i NN cord-280130-ewqe9edq 113 12 - - HYPH cord-280130-ewqe9edq 113 13 and and CC cord-280130-ewqe9edq 113 14 TBK-1-directed tbk-1-directe VBD cord-280130-ewqe9edq 113 15 interferon interferon NN cord-280130-ewqe9edq 113 16 responses response NNS cord-280130-ewqe9edq 113 17 Role role NN cord-280130-ewqe9edq 113 18 of of IN cord-280130-ewqe9edq 113 19 double double RB cord-280130-ewqe9edq 113 20 - - HYPH cord-280130-ewqe9edq 113 21 stranded strand VBN cord-280130-ewqe9edq 113 22 RNA RNA NNP cord-280130-ewqe9edq 113 23 and and CC cord-280130-ewqe9edq 113 24 Npro Npro NNP cord-280130-ewqe9edq 113 25 of of IN cord-280130-ewqe9edq 113 26 classical classical JJ cord-280130-ewqe9edq 113 27 swine swine NN cord-280130-ewqe9edq 113 28 fever fever NN cord-280130-ewqe9edq 113 29 virus virus NN cord-280130-ewqe9edq 113 30 in in IN cord-280130-ewqe9edq 113 31 the the DT cord-280130-ewqe9edq 113 32 activation activation NN cord-280130-ewqe9edq 113 33 of of IN cord-280130-ewqe9edq 113 34 monocyte monocyte NNP cord-280130-ewqe9edq 113 35 - - HYPH cord-280130-ewqe9edq 113 36 derived derive VBN cord-280130-ewqe9edq 113 37 dendritic dendritic JJ cord-280130-ewqe9edq 113 38 cells cell NNS cord-280130-ewqe9edq 114 1 The the DT cord-280130-ewqe9edq 114 2 NPro NPro NNP cord-280130-ewqe9edq 114 3 product product NN cord-280130-ewqe9edq 114 4 of of IN cord-280130-ewqe9edq 114 5 bovine bovine JJ cord-280130-ewqe9edq 114 6 viral viral JJ cord-280130-ewqe9edq 114 7 diarrhea diarrhea NN cord-280130-ewqe9edq 114 8 virus virus NN cord-280130-ewqe9edq 114 9 inhibits inhibit VBZ cord-280130-ewqe9edq 114 10 DNA dna NN cord-280130-ewqe9edq 114 11 binding binding NN cord-280130-ewqe9edq 114 12 by by IN cord-280130-ewqe9edq 114 13 interferon interferon NN cord-280130-ewqe9edq 114 14 regulatory regulatory JJ cord-280130-ewqe9edq 114 15 factor factor NN cord-280130-ewqe9edq 114 16 3 3 CD cord-280130-ewqe9edq 114 17 and and CC cord-280130-ewqe9edq 114 18 targets target VBZ cord-280130-ewqe9edq 114 19 it -PRON- PRP cord-280130-ewqe9edq 114 20 for for IN cord-280130-ewqe9edq 114 21 proteasomal proteasomal JJ cord-280130-ewqe9edq 114 22 degradation degradation NN cord-280130-ewqe9edq 114 23 Loss Loss NNP cord-280130-ewqe9edq 114 24 of of IN cord-280130-ewqe9edq 114 25 interferon interferon NN cord-280130-ewqe9edq 114 26 regulatory regulatory JJ cord-280130-ewqe9edq 114 27 factor factor NN cord-280130-ewqe9edq 114 28 3 3 CD cord-280130-ewqe9edq 114 29 in in IN cord-280130-ewqe9edq 114 30 cells cell NNS cord-280130-ewqe9edq 114 31 infected infect VBN cord-280130-ewqe9edq 114 32 with with IN cord-280130-ewqe9edq 114 33 classical classical JJ cord-280130-ewqe9edq 114 34 swine swine NN cord-280130-ewqe9edq 114 35 fever fever NN cord-280130-ewqe9edq 114 36 virus virus NN cord-280130-ewqe9edq 114 37 involves involve VBZ cord-280130-ewqe9edq 114 38 the the DT cord-280130-ewqe9edq 114 39 N n CD cord-280130-ewqe9edq 114 40 - - HYPH cord-280130-ewqe9edq 114 41 terminal terminal NN cord-280130-ewqe9edq 114 42 protease protease NN cord-280130-ewqe9edq 114 43 , , , cord-280130-ewqe9edq 114 44 Npro Npro NNP cord-280130-ewqe9edq 114 45 N(pro N(pro NNP cord-280130-ewqe9edq 114 46 ) ) -RRB- cord-280130-ewqe9edq 114 47 of of IN cord-280130-ewqe9edq 114 48 classical classical JJ cord-280130-ewqe9edq 114 49 swine swine NN cord-280130-ewqe9edq 114 50 fever fever NN cord-280130-ewqe9edq 114 51 virus virus NN cord-280130-ewqe9edq 114 52 is be VBZ cord-280130-ewqe9edq 114 53 an an DT cord-280130-ewqe9edq 114 54 antagonist antagonist NN cord-280130-ewqe9edq 114 55 of of IN cord-280130-ewqe9edq 114 56 double double RB cord-280130-ewqe9edq 114 57 - - HYPH cord-280130-ewqe9edq 114 58 stranded strand VBN cord-280130-ewqe9edq 114 59 RNA rna NN cord-280130-ewqe9edq 114 60 - - HYPH cord-280130-ewqe9edq 114 61 mediated mediate VBN cord-280130-ewqe9edq 114 62 apoptosis apoptosis NN cord-280130-ewqe9edq 114 63 and and CC cord-280130-ewqe9edq 114 64 IFN IFN NNP cord-280130-ewqe9edq 114 65 - - HYPH cord-280130-ewqe9edq 114 66 alpha alpha NN cord-280130-ewqe9edq 114 67 / / SYM cord-280130-ewqe9edq 114 68 beta beta NN cord-280130-ewqe9edq 114 69 induction induction NN cord-280130-ewqe9edq 114 70 Human human JJ cord-280130-ewqe9edq 114 71 papillomavirus papillomavirus NN cord-280130-ewqe9edq 115 1 16 16 CD cord-280130-ewqe9edq 115 2 E6 E6 NNP cord-280130-ewqe9edq 115 3 oncoprotein oncoprotein NN cord-280130-ewqe9edq 115 4 binds bind VBZ cord-280130-ewqe9edq 115 5 to to IN cord-280130-ewqe9edq 115 6 interferon interferon NN cord-280130-ewqe9edq 115 7 regulatory regulatory JJ cord-280130-ewqe9edq 115 8 factor-3 factor-3 NNP cord-280130-ewqe9edq 115 9 and and CC cord-280130-ewqe9edq 115 10 inhibits inhibit VBZ cord-280130-ewqe9edq 115 11 its -PRON- PRP$ cord-280130-ewqe9edq 115 12 transcriptional transcriptional JJ cord-280130-ewqe9edq 115 13 activity activity NN cord-280130-ewqe9edq 115 14 Functional functional JJ cord-280130-ewqe9edq 115 15 analysis analysis NN cord-280130-ewqe9edq 115 16 of of IN cord-280130-ewqe9edq 115 17 human human JJ cord-280130-ewqe9edq 115 18 herpesvirus herpesvirus NN cord-280130-ewqe9edq 115 19 8-encoded 8-encoded CD cord-280130-ewqe9edq 115 20 viral viral JJ cord-280130-ewqe9edq 115 21 interferon interferon NN cord-280130-ewqe9edq 115 22 regulatory regulatory JJ cord-280130-ewqe9edq 115 23 factor factor NN cord-280130-ewqe9edq 115 24 1 1 CD cord-280130-ewqe9edq 115 25 and and CC cord-280130-ewqe9edq 115 26 its -PRON- PRP$ cord-280130-ewqe9edq 115 27 association association NN cord-280130-ewqe9edq 115 28 with with IN cord-280130-ewqe9edq 115 29 cellular cellular JJ cord-280130-ewqe9edq 115 30 interferon interferon NN cord-280130-ewqe9edq 115 31 regulatory regulatory JJ cord-280130-ewqe9edq 115 32 factors factor NNS cord-280130-ewqe9edq 115 33 and and CC cord-280130-ewqe9edq 115 34 p300 p300 NN cord-280130-ewqe9edq 115 35 Unique unique JJ cord-280130-ewqe9edq 115 36 properties property NNS cord-280130-ewqe9edq 115 37 of of IN cord-280130-ewqe9edq 115 38 a a DT cord-280130-ewqe9edq 115 39 second second JJ cord-280130-ewqe9edq 115 40 human human JJ cord-280130-ewqe9edq 115 41 herpesvirus herpesvirus NN cord-280130-ewqe9edq 115 42 8-encoded 8-encoded CD cord-280130-ewqe9edq 115 43 interferon interferon NN cord-280130-ewqe9edq 115 44 regulatory regulatory JJ cord-280130-ewqe9edq 115 45 factor factor NN cord-280130-ewqe9edq 115 46 ( ( -LRB- cord-280130-ewqe9edq 115 47 vIRF-2 virf-2 CD cord-280130-ewqe9edq 115 48 ) ) -RRB- cord-280130-ewqe9edq 115 49 Inhibition inhibition NN cord-280130-ewqe9edq 115 50 of of IN cord-280130-ewqe9edq 115 51 interferon interferon NN cord-280130-ewqe9edq 115 52 signaling signal VBG cord-280130-ewqe9edq 115 53 by by IN cord-280130-ewqe9edq 115 54 the the DT cord-280130-ewqe9edq 115 55 Kaposi Kaposi NNP cord-280130-ewqe9edq 115 56 's 's POS cord-280130-ewqe9edq 115 57 sarcoma sarcoma NN cord-280130-ewqe9edq 115 58 - - HYPH cord-280130-ewqe9edq 115 59 associated associate VBN cord-280130-ewqe9edq 115 60 herpesvirus herpesvirus NN cord-280130-ewqe9edq 115 61 full full JJ cord-280130-ewqe9edq 115 62 - - HYPH cord-280130-ewqe9edq 115 63 length length NN cord-280130-ewqe9edq 115 64 viral viral JJ cord-280130-ewqe9edq 115 65 interferon interferon NN cord-280130-ewqe9edq 115 66 regulatory regulatory JJ cord-280130-ewqe9edq 115 67 factor factor NN cord-280130-ewqe9edq 115 68 2 2 CD cord-280130-ewqe9edq 115 69 protein protein NN cord-280130-ewqe9edq 115 70 Kaposi Kaposi NNP cord-280130-ewqe9edq 115 71 's 's POS cord-280130-ewqe9edq 115 72 sarcoma sarcoma NN cord-280130-ewqe9edq 115 73 - - HYPH cord-280130-ewqe9edq 115 74 associated associate VBN cord-280130-ewqe9edq 115 75 herpesvirus herpesvirus NN cord-280130-ewqe9edq 115 76 viral viral JJ cord-280130-ewqe9edq 115 77 interferon interferon NN cord-280130-ewqe9edq 115 78 regulatory regulatory JJ cord-280130-ewqe9edq 115 79 factor factor NN cord-280130-ewqe9edq 115 80 Characterization characterization NN cord-280130-ewqe9edq 115 81 of of IN cord-280130-ewqe9edq 115 82 a a DT cord-280130-ewqe9edq 115 83 novel novel JJ cord-280130-ewqe9edq 115 84 human human JJ cord-280130-ewqe9edq 115 85 herpesvirus herpesvirus NN cord-280130-ewqe9edq 115 86 8-encoded 8-encoded CD cord-280130-ewqe9edq 115 87 protein protein NN cord-280130-ewqe9edq 115 88 , , , cord-280130-ewqe9edq 115 89 vIRF-3 virf-3 CD cord-280130-ewqe9edq 115 90 , , , cord-280130-ewqe9edq 115 91 that that DT cord-280130-ewqe9edq 115 92 shows show VBZ cord-280130-ewqe9edq 115 93 homology homology NN cord-280130-ewqe9edq 115 94 to to IN cord-280130-ewqe9edq 115 95 viral viral JJ cord-280130-ewqe9edq 115 96 and and CC cord-280130-ewqe9edq 115 97 cellular cellular JJ cord-280130-ewqe9edq 115 98 interferon interferon NN cord-280130-ewqe9edq 115 99 regulatory regulatory JJ cord-280130-ewqe9edq 115 100 factors factor NNS cord-280130-ewqe9edq 116 1 Kaposi Kaposi NNP cord-280130-ewqe9edq 116 2 's 's POS cord-280130-ewqe9edq 116 3 sarcoma sarcoma NN cord-280130-ewqe9edq 116 4 - - HYPH cord-280130-ewqe9edq 116 5 associated associate VBN cord-280130-ewqe9edq 116 6 herpesvirus herpesvirus NN cord-280130-ewqe9edq 116 7 - - HYPH cord-280130-ewqe9edq 116 8 encoded encode VBN cord-280130-ewqe9edq 116 9 vIRF-3 virf-3 NN cord-280130-ewqe9edq 116 10 stimulates stimulate VBZ cord-280130-ewqe9edq 116 11 the the DT cord-280130-ewqe9edq 116 12 transcriptional transcriptional JJ cord-280130-ewqe9edq 116 13 activity activity NN cord-280130-ewqe9edq 116 14 of of IN cord-280130-ewqe9edq 116 15 cellular cellular JJ cord-280130-ewqe9edq 116 16 IRF-3 IRF-3 NNP cord-280130-ewqe9edq 116 17 and and CC cord-280130-ewqe9edq 116 18 IRF-7 IRF-7 NNP cord-280130-ewqe9edq 116 19 Human Human NNP cord-280130-ewqe9edq 116 20 herpesvirus herpesvirus NN cord-280130-ewqe9edq 116 21 8 8 CD cord-280130-ewqe9edq 117 1 encodes encode VBZ cord-280130-ewqe9edq 117 2 an an DT cord-280130-ewqe9edq 117 3 interferon interferon NN cord-280130-ewqe9edq 117 4 regulatory regulatory JJ cord-280130-ewqe9edq 117 5 factor factor NN cord-280130-ewqe9edq 117 6 ( ( -LRB- cord-280130-ewqe9edq 117 7 IRF IRF NNP cord-280130-ewqe9edq 117 8 ) ) -RRB- cord-280130-ewqe9edq 117 9 homolog homolog NN cord-280130-ewqe9edq 117 10 that that WDT cord-280130-ewqe9edq 117 11 represses repress VBZ cord-280130-ewqe9edq 117 12 IRF-1-mediated irf-1-mediate VBN cord-280130-ewqe9edq 117 13 transcription transcription NN cord-280130-ewqe9edq 117 14 NSs nss NN cord-280130-ewqe9edq 117 15 protein protein NN cord-280130-ewqe9edq 117 16 of of IN cord-280130-ewqe9edq 117 17 Rift Rift NNP cord-280130-ewqe9edq 117 18 Valley Valley NNP cord-280130-ewqe9edq 117 19 Fever Fever NNP cord-280130-ewqe9edq 117 20 Virus virus NN cord-280130-ewqe9edq 118 1 blocks block NNS cord-280130-ewqe9edq 118 2 interferon interferon NN cord-280130-ewqe9edq 118 3 production production NN cord-280130-ewqe9edq 118 4 by by IN cord-280130-ewqe9edq 118 5 inhibiting inhibit VBG cord-280130-ewqe9edq 118 6 host host NN cord-280130-ewqe9edq 118 7 gene gene NN cord-280130-ewqe9edq 118 8 transcription transcription NN cord-280130-ewqe9edq 118 9 TFIIH TFIIH NNP cord-280130-ewqe9edq 118 10 transcription transcription NN cord-280130-ewqe9edq 118 11 factor factor NN cord-280130-ewqe9edq 118 12 , , , cord-280130-ewqe9edq 118 13 a a DT cord-280130-ewqe9edq 118 14 target target NN cord-280130-ewqe9edq 118 15 for for IN cord-280130-ewqe9edq 118 16 the the DT cord-280130-ewqe9edq 118 17 Rift Rift NNP cord-280130-ewqe9edq 118 18 Valley Valley NNP cord-280130-ewqe9edq 118 19 hemorrhagic hemorrhagic JJ cord-280130-ewqe9edq 118 20 fever fever NN cord-280130-ewqe9edq 118 21 virus virus NN cord-280130-ewqe9edq 118 22 Inhibition Inhibition NNP cord-280130-ewqe9edq 118 23 of of IN cord-280130-ewqe9edq 118 24 RNA RNA NNP cord-280130-ewqe9edq 118 25 polymerase polymerase NN cord-280130-ewqe9edq 118 26 II II NNP cord-280130-ewqe9edq 118 27 phosphorylation phosphorylation NN cord-280130-ewqe9edq 118 28 by by IN cord-280130-ewqe9edq 118 29 a a DT cord-280130-ewqe9edq 118 30 viral viral JJ cord-280130-ewqe9edq 118 31 interferon interferon NN cord-280130-ewqe9edq 118 32 antagonist antagonist NN cord-280130-ewqe9edq 118 33 Genetic genetic JJ cord-280130-ewqe9edq 118 34 evidence evidence NN cord-280130-ewqe9edq 118 35 for for IN cord-280130-ewqe9edq 118 36 an an DT cord-280130-ewqe9edq 118 37 interferon interferon NN cord-280130-ewqe9edq 118 38 - - HYPH cord-280130-ewqe9edq 118 39 antagonistic antagonistic JJ cord-280130-ewqe9edq 118 40 function function NN cord-280130-ewqe9edq 118 41 of of IN cord-280130-ewqe9edq 118 42 rift rift NNP cord-280130-ewqe9edq 118 43 valley valley NNP cord-280130-ewqe9edq 118 44 fever fever NN cord-280130-ewqe9edq 118 45 virus virus NN cord-280130-ewqe9edq 118 46 nonstructural nonstructural JJ cord-280130-ewqe9edq 118 47 protein protein NN cord-280130-ewqe9edq 118 48 NSs NSs NNP cord-280130-ewqe9edq 118 49 Bunyamwera Bunyamwera NNP cord-280130-ewqe9edq 118 50 bunyavirus bunyavirus NN cord-280130-ewqe9edq 118 51 nonstructural nonstructural JJ cord-280130-ewqe9edq 118 52 protein protein NN cord-280130-ewqe9edq 118 53 NSs NSs NNP cord-280130-ewqe9edq 119 1 counteracts counteract VBZ cord-280130-ewqe9edq 119 2 the the DT cord-280130-ewqe9edq 119 3 induction induction NN cord-280130-ewqe9edq 119 4 of of IN cord-280130-ewqe9edq 119 5 alpha alpha NN cord-280130-ewqe9edq 119 6 / / SYM cord-280130-ewqe9edq 119 7 beta beta NN cord-280130-ewqe9edq 119 8 interferon interferon NN cord-280130-ewqe9edq 119 9 Inhibition Inhibition NNP cord-280130-ewqe9edq 119 10 of of IN cord-280130-ewqe9edq 119 11 host host NN cord-280130-ewqe9edq 120 1 RNA RNA NNP cord-280130-ewqe9edq 120 2 polymerase polymerase NN cord-280130-ewqe9edq 120 3 IIdependent IIdependent NNP cord-280130-ewqe9edq 120 4 transcription transcription NN cord-280130-ewqe9edq 120 5 by by IN cord-280130-ewqe9edq 120 6 vesicular vesicular JJ cord-280130-ewqe9edq 120 7 stomatitis stomatitis NN cord-280130-ewqe9edq 120 8 virus virus NN cord-280130-ewqe9edq 120 9 results result VBZ cord-280130-ewqe9edq 120 10 from from IN cord-280130-ewqe9edq 120 11 inactivation inactivation NN cord-280130-ewqe9edq 120 12 of of IN cord-280130-ewqe9edq 120 13 TFIID TFIID NNP cord-280130-ewqe9edq 120 14 Inhibition Inhibition NNP cord-280130-ewqe9edq 120 15 of of IN cord-280130-ewqe9edq 120 16 Ran Ran NNP cord-280130-ewqe9edq 120 17 guanosine guanosine NN cord-280130-ewqe9edq 120 18 triphosphatase triphosphatase NN cord-280130-ewqe9edq 120 19 - - HYPH cord-280130-ewqe9edq 120 20 dependent dependent JJ cord-280130-ewqe9edq 120 21 nuclear nuclear JJ cord-280130-ewqe9edq 120 22 transport transport NN cord-280130-ewqe9edq 120 23 by by IN cord-280130-ewqe9edq 120 24 the the DT cord-280130-ewqe9edq 120 25 matrix matrix NN cord-280130-ewqe9edq 120 26 protein protein NN cord-280130-ewqe9edq 120 27 of of IN cord-280130-ewqe9edq 120 28 vesicular vesicular JJ cord-280130-ewqe9edq 120 29 stomatitis stomatitis NN cord-280130-ewqe9edq 120 30 virus virus NN cord-280130-ewqe9edq 120 31 Vesicular Vesicular NNP cord-280130-ewqe9edq 120 32 stomatitis stomatitis NN cord-280130-ewqe9edq 120 33 virus virus NN cord-280130-ewqe9edq 120 34 infection infection NN cord-280130-ewqe9edq 120 35 alters alter VBZ cord-280130-ewqe9edq 120 36 the the DT cord-280130-ewqe9edq 120 37 eIF4F eif4f CD cord-280130-ewqe9edq 120 38 translation translation NN cord-280130-ewqe9edq 120 39 initiation initiation NN cord-280130-ewqe9edq 120 40 complex complex NN cord-280130-ewqe9edq 120 41 and and CC cord-280130-ewqe9edq 120 42 causes cause VBZ cord-280130-ewqe9edq 120 43 dephosphorylation dephosphorylation NN cord-280130-ewqe9edq 120 44 of of IN cord-280130-ewqe9edq 120 45 the the DT cord-280130-ewqe9edq 120 46 eIF4E eif4e CD cord-280130-ewqe9edq 120 47 binding bind VBG cord-280130-ewqe9edq 120 48 protein protein NN cord-280130-ewqe9edq 120 49 4E 4E NNP cord-280130-ewqe9edq 120 50 - - : cord-280130-ewqe9edq 120 51 BP1 BP1 NNP cord-280130-ewqe9edq 120 52 The the DT cord-280130-ewqe9edq 120 53 vesicular vesicular JJ cord-280130-ewqe9edq 120 54 stomatitis stomatitis NN cord-280130-ewqe9edq 120 55 virus virus NN cord-280130-ewqe9edq 120 56 matrix matrix NN cord-280130-ewqe9edq 120 57 protein protein NN cord-280130-ewqe9edq 120 58 inhibits inhibit VBZ cord-280130-ewqe9edq 120 59 transcription transcription NN cord-280130-ewqe9edq 120 60 from from IN cord-280130-ewqe9edq 120 61 the the DT cord-280130-ewqe9edq 120 62 human human JJ cord-280130-ewqe9edq 120 63 beta beta NN cord-280130-ewqe9edq 120 64 interferon interferon NN cord-280130-ewqe9edq 120 65 promoter promoter NN cord-280130-ewqe9edq 120 66 VSV VSV NNP cord-280130-ewqe9edq 120 67 strains strain NNS cord-280130-ewqe9edq 120 68 with with IN cord-280130-ewqe9edq 120 69 defects defect NNS cord-280130-ewqe9edq 120 70 in in IN cord-280130-ewqe9edq 120 71 their -PRON- PRP$ cord-280130-ewqe9edq 120 72 ability ability NN cord-280130-ewqe9edq 120 73 to to TO cord-280130-ewqe9edq 120 74 shutdown shutdown VB cord-280130-ewqe9edq 120 75 innate innate JJ cord-280130-ewqe9edq 120 76 immunity immunity NN cord-280130-ewqe9edq 120 77 are be VBP cord-280130-ewqe9edq 120 78 potent potent JJ cord-280130-ewqe9edq 120 79 systemic systemic JJ cord-280130-ewqe9edq 120 80 anti anti JJ cord-280130-ewqe9edq 120 81 - - JJ cord-280130-ewqe9edq 120 82 cancer cancer JJ cord-280130-ewqe9edq 120 83 agents agent NNS cord-280130-ewqe9edq 121 1 The the DT cord-280130-ewqe9edq 121 2 leader leader NN cord-280130-ewqe9edq 121 3 protein protein NN cord-280130-ewqe9edq 121 4 of of IN cord-280130-ewqe9edq 121 5 Theiler Theiler NNP cord-280130-ewqe9edq 121 6 's 's POS cord-280130-ewqe9edq 121 7 virus virus NN cord-280130-ewqe9edq 121 8 interferes interfere VBZ cord-280130-ewqe9edq 121 9 with with IN cord-280130-ewqe9edq 121 10 nucleocytoplasmic nucleocytoplasmic JJ cord-280130-ewqe9edq 121 11 trafficking trafficking NN cord-280130-ewqe9edq 121 12 of of IN cord-280130-ewqe9edq 121 13 cellular cellular JJ cord-280130-ewqe9edq 121 14 proteins protein NNS cord-280130-ewqe9edq 122 1 The the DT cord-280130-ewqe9edq 122 2 leader leader NN cord-280130-ewqe9edq 122 3 proteinase proteinase NN cord-280130-ewqe9edq 122 4 of of IN cord-280130-ewqe9edq 122 5 foot foot NN cord-280130-ewqe9edq 122 6 - - HYPH cord-280130-ewqe9edq 122 7 and and CC cord-280130-ewqe9edq 122 8 - - HYPH cord-280130-ewqe9edq 122 9 mouth mouth NN cord-280130-ewqe9edq 122 10 disease disease NN cord-280130-ewqe9edq 122 11 virus virus NN cord-280130-ewqe9edq 122 12 inhibits inhibit VBZ cord-280130-ewqe9edq 122 13 the the DT cord-280130-ewqe9edq 122 14 induction induction NN cord-280130-ewqe9edq 122 15 of of IN cord-280130-ewqe9edq 122 16 beta beta NNP cord-280130-ewqe9edq 122 17 interferon interferon NN cord-280130-ewqe9edq 122 18 mRNA mRNA NNP cord-280130-ewqe9edq 122 19 and and CC cord-280130-ewqe9edq 122 20 blocks block VBZ cord-280130-ewqe9edq 122 21 the the DT cord-280130-ewqe9edq 122 22 host host NN cord-280130-ewqe9edq 122 23 innate innate JJ cord-280130-ewqe9edq 122 24 immune immune JJ cord-280130-ewqe9edq 122 25 response response NN cord-280130-ewqe9edq 122 26 Cytopathogenesis Cytopathogenesis NNP cord-280130-ewqe9edq 122 27 and and CC cord-280130-ewqe9edq 122 28 inhibition inhibition NN cord-280130-ewqe9edq 122 29 of of IN cord-280130-ewqe9edq 122 30 host host NN cord-280130-ewqe9edq 122 31 gene gene NN cord-280130-ewqe9edq 122 32 expression expression NN cord-280130-ewqe9edq 122 33 by by IN cord-280130-ewqe9edq 122 34 RNA RNA NNP cord-280130-ewqe9edq 122 35 viruses virus NNS cord-280130-ewqe9edq 122 36 , , , cord-280130-ewqe9edq 122 37 Microbiol Microbiol NNP cord-280130-ewqe9edq 122 38 Classical Classical NNP cord-280130-ewqe9edq 122 39 swine swine NN cord-280130-ewqe9edq 122 40 fever fever NN cord-280130-ewqe9edq 122 41 virus virus NN cord-280130-ewqe9edq 122 42 interferes interfere VBZ cord-280130-ewqe9edq 122 43 with with IN cord-280130-ewqe9edq 122 44 cellular cellular JJ cord-280130-ewqe9edq 122 45 antiviral antiviral JJ cord-280130-ewqe9edq 122 46 defense defense NN cord-280130-ewqe9edq 122 47 : : : cord-280130-ewqe9edq 122 48 evidence evidence NN cord-280130-ewqe9edq 122 49 for for IN cord-280130-ewqe9edq 122 50 a a DT cord-280130-ewqe9edq 122 51 novel novel JJ cord-280130-ewqe9edq 122 52 function function NN cord-280130-ewqe9edq 122 53 of of IN cord-280130-ewqe9edq 122 54 N(pro N(pro NNP cord-280130-ewqe9edq 122 55 ) ) -RRB- cord-280130-ewqe9edq 123 1 The the DT cord-280130-ewqe9edq 123 2 leader leader NN cord-280130-ewqe9edq 123 3 protein protein NN cord-280130-ewqe9edq 123 4 of of IN cord-280130-ewqe9edq 123 5 Theiler Theiler NNP cord-280130-ewqe9edq 123 6 's 's POS cord-280130-ewqe9edq 123 7 virus virus NN cord-280130-ewqe9edq 123 8 inhibits inhibit VBZ cord-280130-ewqe9edq 123 9 immediate immediate JJ cord-280130-ewqe9edq 123 10 - - HYPH cord-280130-ewqe9edq 123 11 early early JJ cord-280130-ewqe9edq 123 12 alpha alpha NN cord-280130-ewqe9edq 123 13 / / SYM cord-280130-ewqe9edq 123 14 beta beta NN cord-280130-ewqe9edq 123 15 interferon interferon NN cord-280130-ewqe9edq 123 16 production production NN cord-280130-ewqe9edq 124 1 Influenza Influenza NNP cord-280130-ewqe9edq 124 2 A A NNP cord-280130-ewqe9edq 125 1 virus virus NN cord-280130-ewqe9edq 125 2 NS1 NS1 NNP cord-280130-ewqe9edq 125 3 protein protein NN cord-280130-ewqe9edq 125 4 targets target NNS cord-280130-ewqe9edq 126 1 poly(A)-binding poly(A)-binding NNP cord-280130-ewqe9edq 127 1 protein protein NNP cord-280130-ewqe9edq 127 2 II II NNP cord-280130-ewqe9edq 127 3 of of IN cord-280130-ewqe9edq 127 4 the the DT cord-280130-ewqe9edq 127 5 cellular cellular JJ cord-280130-ewqe9edq 127 6 3 3 CD cord-280130-ewqe9edq 127 7 0 0 CD cord-280130-ewqe9edq 127 8 -end -end HYPH cord-280130-ewqe9edq 127 9 processing process VBG cord-280130-ewqe9edq 127 10 machinery machinery NN cord-280130-ewqe9edq 127 11 Influenza Influenza NNP cord-280130-ewqe9edq 127 12 virus virus NN cord-280130-ewqe9edq 127 13 NS1 ns1 CD cord-280130-ewqe9edq 127 14 protein protein NN cord-280130-ewqe9edq 128 1 inhibits inhibit VBZ cord-280130-ewqe9edq 128 2 pre pre JJ cord-280130-ewqe9edq 128 3 - - JJ cord-280130-ewqe9edq 128 4 mRNA mrna JJ cord-280130-ewqe9edq 128 5 splicing splicing NN cord-280130-ewqe9edq 128 6 and and CC cord-280130-ewqe9edq 128 7 blocks block NNS cord-280130-ewqe9edq 129 1 mRNA mRNA NNP cord-280130-ewqe9edq 130 1 nucleocytoplasmic nucleocytoplasmic NNP cord-280130-ewqe9edq 130 2 transport transport NNP cord-280130-ewqe9edq 131 1 The the DT cord-280130-ewqe9edq 131 2 3 3 CD cord-280130-ewqe9edq 131 3 0 0 CD cord-280130-ewqe9edq 131 4 -end -end : cord-280130-ewqe9edq 131 5 - - HYPH cord-280130-ewqe9edq 131 6 processing processing NN cord-280130-ewqe9edq 131 7 factor factor NN cord-280130-ewqe9edq 131 8 CPSF CPSF NNP cord-280130-ewqe9edq 131 9 is be VBZ cord-280130-ewqe9edq 131 10 required require VBN cord-280130-ewqe9edq 131 11 for for IN cord-280130-ewqe9edq 131 12 the the DT cord-280130-ewqe9edq 131 13 splicing splicing NN cord-280130-ewqe9edq 131 14 of of IN cord-280130-ewqe9edq 131 15 single single JJ cord-280130-ewqe9edq 131 16 - - HYPH cord-280130-ewqe9edq 131 17 intron intron NN cord-280130-ewqe9edq 131 18 pre pre NN cord-280130-ewqe9edq 131 19 - - NNS cord-280130-ewqe9edq 131 20 mRNAs mRNAs NNPS cord-280130-ewqe9edq 131 21 in in IN cord-280130-ewqe9edq 131 22 vivo vivo NNP cord-280130-ewqe9edq 131 23 Human human JJ cord-280130-ewqe9edq 131 24 influenza influenza NN cord-280130-ewqe9edq 131 25 viruses virus NNS cord-280130-ewqe9edq 131 26 activate activate VBP cord-280130-ewqe9edq 131 27 an an DT cord-280130-ewqe9edq 131 28 interferon interferon NN cord-280130-ewqe9edq 131 29 - - HYPH cord-280130-ewqe9edq 131 30 independent independent JJ cord-280130-ewqe9edq 131 31 transcription transcription NN cord-280130-ewqe9edq 131 32 of of IN cord-280130-ewqe9edq 131 33 cellular cellular JJ cord-280130-ewqe9edq 131 34 antiviral antiviral JJ cord-280130-ewqe9edq 131 35 genes gene NNS cord-280130-ewqe9edq 131 36 : : : cord-280130-ewqe9edq 131 37 outcome outcome VB cord-280130-ewqe9edq 131 38 with with IN cord-280130-ewqe9edq 131 39 influenza influenza NN cord-280130-ewqe9edq 131 40 A a DT cord-280130-ewqe9edq 131 41 virus virus NN cord-280130-ewqe9edq 131 42 is be VBZ cord-280130-ewqe9edq 131 43 unique unique JJ cord-280130-ewqe9edq 131 44 Cellular cellular JJ cord-280130-ewqe9edq 131 45 antiviral antiviral JJ cord-280130-ewqe9edq 131 46 responses response NNS cord-280130-ewqe9edq 131 47 against against IN cord-280130-ewqe9edq 131 48 influenza influenza NN cord-280130-ewqe9edq 131 49 A a DT cord-280130-ewqe9edq 131 50 virus virus NN cord-280130-ewqe9edq 131 51 are be VBP cord-280130-ewqe9edq 131 52 countered counter VBN cord-280130-ewqe9edq 131 53 at at IN cord-280130-ewqe9edq 131 54 the the DT cord-280130-ewqe9edq 131 55 posttranscriptional posttranscriptional JJ cord-280130-ewqe9edq 131 56 level level NN cord-280130-ewqe9edq 131 57 by by IN cord-280130-ewqe9edq 131 58 the the DT cord-280130-ewqe9edq 131 59 viral viral JJ cord-280130-ewqe9edq 131 60 NS1A NS1A NNP cord-280130-ewqe9edq 131 61 protein protein NN cord-280130-ewqe9edq 131 62 via via IN cord-280130-ewqe9edq 131 63 its -PRON- PRP$ cord-280130-ewqe9edq 131 64 binding binding NN cord-280130-ewqe9edq 131 65 to to IN cord-280130-ewqe9edq 131 66 a a DT cord-280130-ewqe9edq 131 67 cellular cellular JJ cord-280130-ewqe9edq 131 68 protein protein NN cord-280130-ewqe9edq 131 69 required require VBN cord-280130-ewqe9edq 131 70 for for IN cord-280130-ewqe9edq 131 71 the the DT cord-280130-ewqe9edq 131 72 3 3 CD cord-280130-ewqe9edq 131 73 0 0 CD cord-280130-ewqe9edq 131 74 end end NN cord-280130-ewqe9edq 131 75 processing processing NN cord-280130-ewqe9edq 131 76 of of IN cord-280130-ewqe9edq 131 77 cellular cellular JJ cord-280130-ewqe9edq 131 78 pre pre NN cord-280130-ewqe9edq 131 79 - - JJ cord-280130-ewqe9edq 131 80 mRNAS mrnas JJ cord-280130-ewqe9edq 131 81 Variation variation NN cord-280130-ewqe9edq 131 82 in in IN cord-280130-ewqe9edq 131 83 the the DT cord-280130-ewqe9edq 131 84 ability ability NN cord-280130-ewqe9edq 131 85 of of IN cord-280130-ewqe9edq 131 86 human human JJ cord-280130-ewqe9edq 131 87 influenza influenza NN cord-280130-ewqe9edq 131 88 A a DT cord-280130-ewqe9edq 131 89 viruses virus NNS cord-280130-ewqe9edq 131 90 to to TO cord-280130-ewqe9edq 131 91 induce induce VB cord-280130-ewqe9edq 131 92 and and CC cord-280130-ewqe9edq 131 93 inhibit inhibit VB cord-280130-ewqe9edq 131 94 the the DT cord-280130-ewqe9edq 131 95 IFN IFN NNP cord-280130-ewqe9edq 131 96 - - HYPH cord-280130-ewqe9edq 131 97 beta beta NN cord-280130-ewqe9edq 131 98 pathway pathway NN cord-280130-ewqe9edq 131 99 Stats stat NNS cord-280130-ewqe9edq 131 100 : : : cord-280130-ewqe9edq 131 101 transcriptional transcriptional JJ cord-280130-ewqe9edq 131 102 control control NN cord-280130-ewqe9edq 131 103 and and CC cord-280130-ewqe9edq 131 104 biological biological JJ cord-280130-ewqe9edq 131 105 impact impact NN cord-280130-ewqe9edq 131 106 Degradation degradation NN cord-280130-ewqe9edq 131 107 of of IN cord-280130-ewqe9edq 131 108 STAT1 stat1 NN cord-280130-ewqe9edq 131 109 and and CC cord-280130-ewqe9edq 131 110 STAT2 STAT2 NNS cord-280130-ewqe9edq 131 111 by by IN cord-280130-ewqe9edq 131 112 the the DT cord-280130-ewqe9edq 131 113 V v NN cord-280130-ewqe9edq 131 114 proteins protein NNS cord-280130-ewqe9edq 131 115 of of IN cord-280130-ewqe9edq 131 116 simian simian JJ cord-280130-ewqe9edq 131 117 virus virus NN cord-280130-ewqe9edq 131 118 5 5 CD cord-280130-ewqe9edq 131 119 and and CC cord-280130-ewqe9edq 131 120 human human JJ cord-280130-ewqe9edq 131 121 parainfluenza parainfluenza NNP cord-280130-ewqe9edq 131 122 virus virus NNP cord-280130-ewqe9edq 131 123 type type NNP cord-280130-ewqe9edq 131 124 2 2 CD cord-280130-ewqe9edq 131 125 , , , cord-280130-ewqe9edq 131 126 respectively respectively RB cord-280130-ewqe9edq 131 127 : : : cord-280130-ewqe9edq 131 128 consequences consequence NNS cord-280130-ewqe9edq 131 129 for for IN cord-280130-ewqe9edq 131 130 virus virus NN cord-280130-ewqe9edq 131 131 replication replication NN cord-280130-ewqe9edq 131 132 in in IN cord-280130-ewqe9edq 131 133 the the DT cord-280130-ewqe9edq 131 134 presence presence NN cord-280130-ewqe9edq 131 135 of of IN cord-280130-ewqe9edq 131 136 alpha alpha NN cord-280130-ewqe9edq 131 137 / / SYM cord-280130-ewqe9edq 131 138 beta beta NN cord-280130-ewqe9edq 131 139 and and CC cord-280130-ewqe9edq 131 140 gamma gamma NN cord-280130-ewqe9edq 131 141 interferons interferon NNS cord-280130-ewqe9edq 132 1 The the DT cord-280130-ewqe9edq 132 2 V V NNP cord-280130-ewqe9edq 132 3 protein protein NN cord-280130-ewqe9edq 132 4 of of IN cord-280130-ewqe9edq 132 5 simian simian JJ cord-280130-ewqe9edq 132 6 virus virus NN cord-280130-ewqe9edq 132 7 5 5 CD cord-280130-ewqe9edq 132 8 inhibits inhibit VBZ cord-280130-ewqe9edq 132 9 interferon interferon NN cord-280130-ewqe9edq 132 10 signalling signal VBG cord-280130-ewqe9edq 132 11 by by IN cord-280130-ewqe9edq 132 12 targeting target VBG cord-280130-ewqe9edq 132 13 STAT1 stat1 NN cord-280130-ewqe9edq 132 14 for for IN cord-280130-ewqe9edq 132 15 proteasome proteasome NN cord-280130-ewqe9edq 132 16 - - HYPH cord-280130-ewqe9edq 132 17 mediated mediate VBN cord-280130-ewqe9edq 132 18 degradation degradation NN cord-280130-ewqe9edq 132 19 All all DT cord-280130-ewqe9edq 132 20 four four CD cord-280130-ewqe9edq 132 21 Sendai Sendai NNP cord-280130-ewqe9edq 132 22 Virus Virus NNP cord-280130-ewqe9edq 132 23 C c NN cord-280130-ewqe9edq 132 24 proteins protein NNS cord-280130-ewqe9edq 132 25 bind bind VBP cord-280130-ewqe9edq 132 26 Stat1 Stat1 NNS cord-280130-ewqe9edq 132 27 , , , cord-280130-ewqe9edq 132 28 but but CC cord-280130-ewqe9edq 132 29 only only RB cord-280130-ewqe9edq 132 30 the the DT cord-280130-ewqe9edq 132 31 larger large JJR cord-280130-ewqe9edq 132 32 forms form NNS cord-280130-ewqe9edq 132 33 also also RB cord-280130-ewqe9edq 132 34 induce induce VBP cord-280130-ewqe9edq 132 35 its -PRON- PRP$ cord-280130-ewqe9edq 132 36 mono mono NN cord-280130-ewqe9edq 132 37 - - HYPH cord-280130-ewqe9edq 132 38 ubiquitination ubiquitination NN cord-280130-ewqe9edq 132 39 and and CC cord-280130-ewqe9edq 132 40 degradation degradation NN cord-280130-ewqe9edq 133 1 The the DT cord-280130-ewqe9edq 133 2 V V NNP cord-280130-ewqe9edq 133 3 protein protein NN cord-280130-ewqe9edq 133 4 of of IN cord-280130-ewqe9edq 133 5 human human JJ cord-280130-ewqe9edq 133 6 parainfluenza parainfluenza NNP cord-280130-ewqe9edq 133 7 virus virus NNP cord-280130-ewqe9edq 133 8 2 2 CD cord-280130-ewqe9edq 133 9 antagonizes antagonize VBZ cord-280130-ewqe9edq 133 10 type type NN cord-280130-ewqe9edq 133 11 I -PRON- PRP cord-280130-ewqe9edq 133 12 interferon interferon NN cord-280130-ewqe9edq 133 13 responses response NNS cord-280130-ewqe9edq 133 14 by by IN cord-280130-ewqe9edq 133 15 destabilizing destabilize VBG cord-280130-ewqe9edq 133 16 signal signal NN cord-280130-ewqe9edq 133 17 transducer transducer NN cord-280130-ewqe9edq 133 18 and and CC cord-280130-ewqe9edq 133 19 activator activator NN cord-280130-ewqe9edq 133 20 of of IN cord-280130-ewqe9edq 133 21 transcription transcription NN cord-280130-ewqe9edq 133 22 2 2 CD cord-280130-ewqe9edq 133 23 STAT3 stat3 CD cord-280130-ewqe9edq 133 24 ubiquitylation ubiquitylation NN cord-280130-ewqe9edq 133 25 and and CC cord-280130-ewqe9edq 133 26 degradation degradation NN cord-280130-ewqe9edq 133 27 by by IN cord-280130-ewqe9edq 133 28 mumps mumps NN cord-280130-ewqe9edq 133 29 virus virus NN cord-280130-ewqe9edq 133 30 suppress suppress VBP cord-280130-ewqe9edq 133 31 cytokine cytokine NN cord-280130-ewqe9edq 133 32 and and CC cord-280130-ewqe9edq 133 33 oncogene oncogene NN cord-280130-ewqe9edq 133 34 signaling signal VBG cord-280130-ewqe9edq 133 35 The the DT cord-280130-ewqe9edq 133 36 STAT2 STAT2 NNS cord-280130-ewqe9edq 133 37 activation activation NN cord-280130-ewqe9edq 133 38 process process NN cord-280130-ewqe9edq 133 39 is be VBZ cord-280130-ewqe9edq 133 40 a a DT cord-280130-ewqe9edq 133 41 crucial crucial JJ cord-280130-ewqe9edq 133 42 target target NN cord-280130-ewqe9edq 133 43 of of IN cord-280130-ewqe9edq 133 44 Sendai Sendai NNP cord-280130-ewqe9edq 133 45 virus virus NN cord-280130-ewqe9edq 133 46 C c NN cord-280130-ewqe9edq 133 47 protein protein NN cord-280130-ewqe9edq 133 48 for for IN cord-280130-ewqe9edq 133 49 the the DT cord-280130-ewqe9edq 133 50 blockade blockade NN cord-280130-ewqe9edq 133 51 of of IN cord-280130-ewqe9edq 133 52 alpha alpha NN cord-280130-ewqe9edq 133 53 interferon interferon NN cord-280130-ewqe9edq 133 54 signaling signal VBG cord-280130-ewqe9edq 133 55 Rinderpest rinderpest NN cord-280130-ewqe9edq 133 56 virus virus NN cord-280130-ewqe9edq 133 57 blocks block VBZ cord-280130-ewqe9edq 133 58 type type NN cord-280130-ewqe9edq 133 59 I -PRON- PRP cord-280130-ewqe9edq 133 60 and and CC cord-280130-ewqe9edq 133 61 type type NN cord-280130-ewqe9edq 133 62 II II NNP cord-280130-ewqe9edq 133 63 interferon interferon NN cord-280130-ewqe9edq 133 64 action action NN cord-280130-ewqe9edq 133 65 : : : cord-280130-ewqe9edq 133 66 role role NN cord-280130-ewqe9edq 133 67 of of IN cord-280130-ewqe9edq 133 68 structural structural JJ cord-280130-ewqe9edq 133 69 and and CC cord-280130-ewqe9edq 133 70 nonstructural nonstructural JJ cord-280130-ewqe9edq 133 71 proteins protein NNS cord-280130-ewqe9edq 133 72 STAT stat NN cord-280130-ewqe9edq 133 73 protein protein NN cord-280130-ewqe9edq 133 74 interference interference NN cord-280130-ewqe9edq 133 75 and and CC cord-280130-ewqe9edq 133 76 suppression suppression NN cord-280130-ewqe9edq 133 77 of of IN cord-280130-ewqe9edq 133 78 cytokine cytokine NN cord-280130-ewqe9edq 133 79 signal signal NN cord-280130-ewqe9edq 133 80 transduction transduction NN cord-280130-ewqe9edq 133 81 by by IN cord-280130-ewqe9edq 133 82 measles measle NNS cord-280130-ewqe9edq 133 83 virus virus NN cord-280130-ewqe9edq 133 84 V V NNP cord-280130-ewqe9edq 133 85 protein protein NN cord-280130-ewqe9edq 133 86 Newcastle Newcastle NNP cord-280130-ewqe9edq 133 87 disease disease NN cord-280130-ewqe9edq 133 88 virus virus NN cord-280130-ewqe9edq 133 89 ( ( -LRB- cord-280130-ewqe9edq 133 90 NDV)-based ndv)-based JJ cord-280130-ewqe9edq 133 91 assay assay NN cord-280130-ewqe9edq 133 92 demonstrates demonstrate VBZ cord-280130-ewqe9edq 133 93 interferon interferon NN cord-280130-ewqe9edq 133 94 - - HYPH cord-280130-ewqe9edq 133 95 antagonist antagonist NN cord-280130-ewqe9edq 133 96 activity activity NN cord-280130-ewqe9edq 133 97 for for IN cord-280130-ewqe9edq 133 98 the the DT cord-280130-ewqe9edq 133 99 NDV NDV NNP cord-280130-ewqe9edq 133 100 V V NNP cord-280130-ewqe9edq 133 101 protein protein NN cord-280130-ewqe9edq 133 102 and and CC cord-280130-ewqe9edq 133 103 the the DT cord-280130-ewqe9edq 133 104 Nipah Nipah NNP cord-280130-ewqe9edq 133 105 virus virus NN cord-280130-ewqe9edq 133 106 V v NN cord-280130-ewqe9edq 133 107 , , , cord-280130-ewqe9edq 133 108 W W NNP cord-280130-ewqe9edq 133 109 , , , cord-280130-ewqe9edq 133 110 and and CC cord-280130-ewqe9edq 134 1 C C NNP cord-280130-ewqe9edq 134 2 proteins protein NNS cord-280130-ewqe9edq 135 1 Nipah Nipah NNP cord-280130-ewqe9edq 135 2 virus virus NN cord-280130-ewqe9edq 135 3 V v NN cord-280130-ewqe9edq 135 4 protein protein NN cord-280130-ewqe9edq 135 5 evades evade VBZ cord-280130-ewqe9edq 135 6 alpha alpha NN cord-280130-ewqe9edq 135 7 and and CC cord-280130-ewqe9edq 135 8 gamma gamma NN cord-280130-ewqe9edq 135 9 interferons interferon NNS cord-280130-ewqe9edq 135 10 by by IN cord-280130-ewqe9edq 135 11 preventing prevent VBG cord-280130-ewqe9edq 136 1 STAT1 STAT1 NNP cord-280130-ewqe9edq 136 2 and and CC cord-280130-ewqe9edq 136 3 STAT2 STAT2 NNS cord-280130-ewqe9edq 136 4 activation activation NN cord-280130-ewqe9edq 136 5 and and CC cord-280130-ewqe9edq 136 6 nuclear nuclear JJ cord-280130-ewqe9edq 136 7 accumulation accumulation NN cord-280130-ewqe9edq 136 8 Hendra Hendra NNP cord-280130-ewqe9edq 136 9 virus virus NN cord-280130-ewqe9edq 136 10 V v NN cord-280130-ewqe9edq 136 11 protein protein NN cord-280130-ewqe9edq 136 12 inhibits inhibit VBZ cord-280130-ewqe9edq 136 13 interferon interferon NN cord-280130-ewqe9edq 136 14 signaling signal VBG cord-280130-ewqe9edq 136 15 by by IN cord-280130-ewqe9edq 136 16 preventing prevent VBG cord-280130-ewqe9edq 136 17 STAT1 stat1 NN cord-280130-ewqe9edq 136 18 and and CC cord-280130-ewqe9edq 137 1 STAT2 STAT2 NNPS cord-280130-ewqe9edq 137 2 nuclear nuclear JJ cord-280130-ewqe9edq 137 3 accumulation accumulation NN cord-280130-ewqe9edq 137 4 Nipah Nipah NNP cord-280130-ewqe9edq 137 5 virus virus NN cord-280130-ewqe9edq 137 6 V v NN cord-280130-ewqe9edq 137 7 and and CC cord-280130-ewqe9edq 137 8 W w NN cord-280130-ewqe9edq 137 9 proteins protein NNS cord-280130-ewqe9edq 137 10 have have VBP cord-280130-ewqe9edq 137 11 a a DT cord-280130-ewqe9edq 137 12 common common JJ cord-280130-ewqe9edq 137 13 STAT1-binding stat1-binding NN cord-280130-ewqe9edq 137 14 domain domain NN cord-280130-ewqe9edq 138 1 yet yet CC cord-280130-ewqe9edq 138 2 inhibit inhibit VB cord-280130-ewqe9edq 138 3 STAT1 stat1 NN cord-280130-ewqe9edq 138 4 activation activation NN cord-280130-ewqe9edq 138 5 from from IN cord-280130-ewqe9edq 138 6 the the DT cord-280130-ewqe9edq 138 7 cytoplasmic cytoplasmic JJ cord-280130-ewqe9edq 138 8 and and CC cord-280130-ewqe9edq 138 9 nuclear nuclear JJ cord-280130-ewqe9edq 138 10 compartments compartment NNS cord-280130-ewqe9edq 138 11 , , , cord-280130-ewqe9edq 138 12 respectively respectively RB cord-280130-ewqe9edq 138 13 Nuclear nuclear JJ cord-280130-ewqe9edq 138 14 localization localization NN cord-280130-ewqe9edq 138 15 of of IN cord-280130-ewqe9edq 138 16 the the DT cord-280130-ewqe9edq 138 17 Nipah Nipah NNP cord-280130-ewqe9edq 138 18 virus virus NN cord-280130-ewqe9edq 138 19 W w NN cord-280130-ewqe9edq 138 20 protein protein NN cord-280130-ewqe9edq 139 1 allows allow VBZ cord-280130-ewqe9edq 139 2 for for IN cord-280130-ewqe9edq 139 3 inhibition inhibition NN cord-280130-ewqe9edq 139 4 of of IN cord-280130-ewqe9edq 139 5 both both DT cord-280130-ewqe9edq 139 6 virus virus NN cord-280130-ewqe9edq 139 7 - - : cord-280130-ewqe9edq 139 8 and and CC cord-280130-ewqe9edq 139 9 toll toll NN cord-280130-ewqe9edq 139 10 - - HYPH cord-280130-ewqe9edq 139 11 like like JJ cord-280130-ewqe9edq 139 12 receptor receptor NN cord-280130-ewqe9edq 139 13 3-triggered 3-triggered CD cord-280130-ewqe9edq 139 14 signaling signal VBG cord-280130-ewqe9edq 139 15 pathways pathway NNS cord-280130-ewqe9edq 139 16 Sendai Sendai NNP cord-280130-ewqe9edq 139 17 virus virus NN cord-280130-ewqe9edq 139 18 C c NN cord-280130-ewqe9edq 139 19 protein protein NN cord-280130-ewqe9edq 139 20 physically physically RB cord-280130-ewqe9edq 139 21 associates associate VBZ cord-280130-ewqe9edq 139 22 with with IN cord-280130-ewqe9edq 139 23 Stat1 Stat1 NNS cord-280130-ewqe9edq 140 1 Measles measles NN cord-280130-ewqe9edq 140 2 virus virus NN cord-280130-ewqe9edq 140 3 suppresses suppress VBZ cord-280130-ewqe9edq 140 4 interferon interferon NN cord-280130-ewqe9edq 140 5 - - HYPH cord-280130-ewqe9edq 140 6 alpha alpha NN cord-280130-ewqe9edq 140 7 signaling signaling NN cord-280130-ewqe9edq 140 8 pathway pathway NN cord-280130-ewqe9edq 140 9 : : : cord-280130-ewqe9edq 140 10 suppression suppression NN cord-280130-ewqe9edq 140 11 of of IN cord-280130-ewqe9edq 140 12 Jak1 Jak1 NNP cord-280130-ewqe9edq 140 13 phosphorylation phosphorylation NN cord-280130-ewqe9edq 140 14 and and CC cord-280130-ewqe9edq 140 15 association association NN cord-280130-ewqe9edq 140 16 of of IN cord-280130-ewqe9edq 140 17 viral viral JJ cord-280130-ewqe9edq 140 18 accessory accessory NN cord-280130-ewqe9edq 140 19 proteins protein NNS cord-280130-ewqe9edq 140 20 , , , cord-280130-ewqe9edq 140 21 C C NNP cord-280130-ewqe9edq 140 22 and and CC cord-280130-ewqe9edq 140 23 V V NNP cord-280130-ewqe9edq 140 24 , , , cord-280130-ewqe9edq 140 25 with with IN cord-280130-ewqe9edq 140 26 interferon interferon NN cord-280130-ewqe9edq 140 27 - - HYPH cord-280130-ewqe9edq 140 28 alpha alpha NN cord-280130-ewqe9edq 140 29 receptor receptor NN cord-280130-ewqe9edq 140 30 complex complex JJ cord-280130-ewqe9edq 140 31 Inhibition inhibition NN cord-280130-ewqe9edq 140 32 of of IN cord-280130-ewqe9edq 140 33 interferon interferon NN cord-280130-ewqe9edq 140 34 signaling signal VBG cord-280130-ewqe9edq 140 35 by by IN cord-280130-ewqe9edq 140 36 rabies rabies NN cord-280130-ewqe9edq 140 37 virus virus NN cord-280130-ewqe9edq 140 38 phosphoprotein phosphoprotein NN cord-280130-ewqe9edq 140 39 P p NN cord-280130-ewqe9edq 140 40 : : : cord-280130-ewqe9edq 140 41 activation activation NN cord-280130-ewqe9edq 140 42 - - HYPH cord-280130-ewqe9edq 140 43 dependent dependent JJ cord-280130-ewqe9edq 140 44 binding binding NN cord-280130-ewqe9edq 140 45 of of IN cord-280130-ewqe9edq 140 46 STAT1 stat1 NN cord-280130-ewqe9edq 140 47 and and CC cord-280130-ewqe9edq 140 48 STAT2 STAT2 NNS cord-280130-ewqe9edq 140 49 Ebola Ebola NNP cord-280130-ewqe9edq 140 50 virus virus NN cord-280130-ewqe9edq 140 51 VP24 VP24 NNP cord-280130-ewqe9edq 140 52 binds bind VBZ cord-280130-ewqe9edq 140 53 karyopherin karyopherin NNP cord-280130-ewqe9edq 140 54 alpha1 alpha1 NN cord-280130-ewqe9edq 140 55 and and CC cord-280130-ewqe9edq 140 56 blocks block VBZ cord-280130-ewqe9edq 140 57 STAT1 STAT1 NNP cord-280130-ewqe9edq 140 58 nuclear nuclear JJ cord-280130-ewqe9edq 140 59 accumulation accumulation NN cord-280130-ewqe9edq 140 60 Expression expression NN cord-280130-ewqe9edq 140 61 of of IN cord-280130-ewqe9edq 140 62 hepatitis hepatitis NN cord-280130-ewqe9edq 140 63 C C NNP cord-280130-ewqe9edq 140 64 virus virus NN cord-280130-ewqe9edq 140 65 proteins protein NNS cord-280130-ewqe9edq 140 66 interferes interfere VBZ cord-280130-ewqe9edq 140 67 with with IN cord-280130-ewqe9edq 140 68 the the DT cord-280130-ewqe9edq 140 69 antiviral antiviral JJ cord-280130-ewqe9edq 140 70 action action NN cord-280130-ewqe9edq 140 71 of of IN cord-280130-ewqe9edq 140 72 interferon interferon NN cord-280130-ewqe9edq 141 1 independently independently RB cord-280130-ewqe9edq 141 2 of of IN cord-280130-ewqe9edq 141 3 PKR PKR NNP cord-280130-ewqe9edq 141 4 - - HYPH cord-280130-ewqe9edq 141 5 mediated mediate VBN cord-280130-ewqe9edq 141 6 control control NN cord-280130-ewqe9edq 141 7 of of IN cord-280130-ewqe9edq 141 8 protein protein NN cord-280130-ewqe9edq 141 9 synthesis synthesis NN cord-280130-ewqe9edq 141 10 Expression expression NN cord-280130-ewqe9edq 141 11 of of IN cord-280130-ewqe9edq 141 12 hepatitis hepatitis NN cord-280130-ewqe9edq 141 13 C C NNP cord-280130-ewqe9edq 141 14 virus virus NN cord-280130-ewqe9edq 141 15 proteins protein NNS cord-280130-ewqe9edq 141 16 inhibits inhibit VBZ cord-280130-ewqe9edq 141 17 signal signal JJ cord-280130-ewqe9edq 141 18 transduction transduction NN cord-280130-ewqe9edq 141 19 through through IN cord-280130-ewqe9edq 141 20 the the DT cord-280130-ewqe9edq 141 21 Jak Jak NNP cord-280130-ewqe9edq 141 22 - - HYPH cord-280130-ewqe9edq 141 23 STAT STAT NNP cord-280130-ewqe9edq 141 24 pathway pathway NN cord-280130-ewqe9edq 141 25 Herpes Herpes NNP cord-280130-ewqe9edq 141 26 simplex simplex NN cord-280130-ewqe9edq 141 27 virus virus NN cord-280130-ewqe9edq 141 28 1 1 CD cord-280130-ewqe9edq 141 29 gene gene NN cord-280130-ewqe9edq 141 30 products product NNS cord-280130-ewqe9edq 142 1 occlude occlude VB cord-280130-ewqe9edq 142 2 the the DT cord-280130-ewqe9edq 142 3 interferon interferon NN cord-280130-ewqe9edq 142 4 signaling signal VBG cord-280130-ewqe9edq 142 5 pathway pathway NN cord-280130-ewqe9edq 142 6 at at IN cord-280130-ewqe9edq 142 7 multiple multiple JJ cord-280130-ewqe9edq 142 8 sites site NNS cord-280130-ewqe9edq 143 1 Induction induction NN cord-280130-ewqe9edq 143 2 of of IN cord-280130-ewqe9edq 143 3 suppressor suppressor NN cord-280130-ewqe9edq 143 4 of of IN cord-280130-ewqe9edq 143 5 cytokine cytokine NN cord-280130-ewqe9edq 143 6 signaling-3 signaling-3 NNP cord-280130-ewqe9edq 143 7 by by IN cord-280130-ewqe9edq 143 8 herpes herpes NNP cord-280130-ewqe9edq 143 9 simplex simplex NNP cord-280130-ewqe9edq 143 10 virus virus NN cord-280130-ewqe9edq 143 11 type type NN cord-280130-ewqe9edq 143 12 1 1 CD cord-280130-ewqe9edq 143 13 contributes contribute VBZ cord-280130-ewqe9edq 143 14 to to IN cord-280130-ewqe9edq 143 15 inhibition inhibition NN cord-280130-ewqe9edq 143 16 of of IN cord-280130-ewqe9edq 143 17 the the DT cord-280130-ewqe9edq 143 18 interferon interferon NN cord-280130-ewqe9edq 143 19 signaling signal VBG cord-280130-ewqe9edq 143 20 pathway pathway NN cord-280130-ewqe9edq 143 21 A a DT cord-280130-ewqe9edq 143 22 cytomegalovirus cytomegalovirus JJ cord-280130-ewqe9edq 143 23 inhibitor inhibitor NN cord-280130-ewqe9edq 143 24 of of IN cord-280130-ewqe9edq 143 25 gamma gamma NN cord-280130-ewqe9edq 143 26 interferon interferon NN cord-280130-ewqe9edq 143 27 signaling signal VBG cord-280130-ewqe9edq 143 28 controls control NNS cord-280130-ewqe9edq 143 29 immunoproteasome immunoproteasome NNP cord-280130-ewqe9edq 143 30 induction induction NN cord-280130-ewqe9edq 144 1 A a DT cord-280130-ewqe9edq 144 2 cytomegaloviral cytomegaloviral JJ cord-280130-ewqe9edq 144 3 protein protein NN cord-280130-ewqe9edq 144 4 reveals reveal VBZ cord-280130-ewqe9edq 144 5 a a DT cord-280130-ewqe9edq 144 6 dual dual JJ cord-280130-ewqe9edq 144 7 role role NN cord-280130-ewqe9edq 144 8 for for IN cord-280130-ewqe9edq 144 9 STAT2 STAT2 NNS cord-280130-ewqe9edq 144 10 in in IN cord-280130-ewqe9edq 144 11 IFN-{gamma ifn-{gamma NN cord-280130-ewqe9edq 144 12 } } -RRB- cord-280130-ewqe9edq 144 13 signaling signal VBG cord-280130-ewqe9edq 144 14 and and CC cord-280130-ewqe9edq 144 15 antiviral antiviral JJ cord-280130-ewqe9edq 144 16 responses response NNS cord-280130-ewqe9edq 144 17 Vaccinia Vaccinia NNP cord-280130-ewqe9edq 144 18 , , , cord-280130-ewqe9edq 144 19 cowpox cowpox NN cord-280130-ewqe9edq 144 20 , , , cord-280130-ewqe9edq 144 21 and and CC cord-280130-ewqe9edq 144 22 camelpox camelpox NN cord-280130-ewqe9edq 144 23 viruses virus NNS cord-280130-ewqe9edq 144 24 encode encode VBP cord-280130-ewqe9edq 144 25 soluble soluble JJ cord-280130-ewqe9edq 144 26 gamma gamma NN cord-280130-ewqe9edq 144 27 interferon interferon NN cord-280130-ewqe9edq 144 28 receptors receptor NNS cord-280130-ewqe9edq 144 29 with with IN cord-280130-ewqe9edq 144 30 novel novel JJ cord-280130-ewqe9edq 144 31 broad broad JJ cord-280130-ewqe9edq 144 32 species specie NNS cord-280130-ewqe9edq 144 33 specificity specificity NN cord-280130-ewqe9edq 145 1 The the DT cord-280130-ewqe9edq 145 2 vaccinia vaccinia NN cord-280130-ewqe9edq 145 3 virus virus NN cord-280130-ewqe9edq 145 4 soluble soluble JJ cord-280130-ewqe9edq 145 5 alpha/ alpha/ CD cord-280130-ewqe9edq 146 1 beta beta NN cord-280130-ewqe9edq 146 2 interferon interferon NNP cord-280130-ewqe9edq 146 3 ( ( -LRB- cord-280130-ewqe9edq 146 4 IFN IFN NNP cord-280130-ewqe9edq 146 5 ) ) -RRB- cord-280130-ewqe9edq 146 6 receptor receptor NN cord-280130-ewqe9edq 146 7 binds bind VBZ cord-280130-ewqe9edq 146 8 to to IN cord-280130-ewqe9edq 146 9 the the DT cord-280130-ewqe9edq 146 10 cell cell NN cord-280130-ewqe9edq 146 11 surface surface NN cord-280130-ewqe9edq 146 12 and and CC cord-280130-ewqe9edq 146 13 protects protect VBZ cord-280130-ewqe9edq 146 14 cells cell NNS cord-280130-ewqe9edq 146 15 from from IN cord-280130-ewqe9edq 146 16 the the DT cord-280130-ewqe9edq 146 17 antiviral antiviral JJ cord-280130-ewqe9edq 146 18 effects effect NNS cord-280130-ewqe9edq 146 19 of of IN cord-280130-ewqe9edq 146 20 IFN IFN NNP cord-280130-ewqe9edq 146 21 Vaccinia Vaccinia NNP cord-280130-ewqe9edq 146 22 virus virus NN cord-280130-ewqe9edq 146 23 - - HYPH cord-280130-ewqe9edq 146 24 encoded encode VBN cord-280130-ewqe9edq 146 25 cytokine cytokine NN cord-280130-ewqe9edq 146 26 receptor receptor NN cord-280130-ewqe9edq 146 27 binds bind VBZ cord-280130-ewqe9edq 146 28 and and CC cord-280130-ewqe9edq 146 29 neutralizes neutralize VBZ cord-280130-ewqe9edq 146 30 chicken chicken NN cord-280130-ewqe9edq 147 1 interferon interferon NN cord-280130-ewqe9edq 147 2 - - HYPH cord-280130-ewqe9edq 147 3 gamma gamma NN cord-280130-ewqe9edq 147 4 Vaccinia Vaccinia NNP cord-280130-ewqe9edq 147 5 virus virus NN cord-280130-ewqe9edq 147 6 encodes encode VBZ cord-280130-ewqe9edq 147 7 a a DT cord-280130-ewqe9edq 147 8 soluble soluble JJ cord-280130-ewqe9edq 147 9 type type NN cord-280130-ewqe9edq 147 10 I -PRON- PRP cord-280130-ewqe9edq 147 11 interferon interferon VBD cord-280130-ewqe9edq 147 12 receptor receptor NN cord-280130-ewqe9edq 147 13 of of IN cord-280130-ewqe9edq 147 14 novel novel JJ cord-280130-ewqe9edq 147 15 structure structure NN cord-280130-ewqe9edq 147 16 and and CC cord-280130-ewqe9edq 148 1 broad broad JJ cord-280130-ewqe9edq 148 2 species specie NNS cord-280130-ewqe9edq 148 3 specificity specificity NN cord-280130-ewqe9edq 149 1 Influenza influenza NN cord-280130-ewqe9edq 149 2 virus virus NN cord-280130-ewqe9edq 149 3 NS1 ns1 NN cord-280130-ewqe9edq 149 4 protein protein NN cord-280130-ewqe9edq 149 5 counteracts counteract VBZ cord-280130-ewqe9edq 149 6 PKR PKR NNP cord-280130-ewqe9edq 149 7 - - HYPH cord-280130-ewqe9edq 149 8 mediated mediate VBN cord-280130-ewqe9edq 149 9 inhibition inhibition NN cord-280130-ewqe9edq 149 10 of of IN cord-280130-ewqe9edq 149 11 replication replication NN cord-280130-ewqe9edq 149 12 Mutant mutant JJ cord-280130-ewqe9edq 149 13 influenza influenza NN cord-280130-ewqe9edq 149 14 viruses viruse VBZ cord-280130-ewqe9edq 149 15 with with IN cord-280130-ewqe9edq 149 16 a a DT cord-280130-ewqe9edq 149 17 defective defective JJ cord-280130-ewqe9edq 149 18 NS1 NS1 NNS cord-280130-ewqe9edq 149 19 protein protein NN cord-280130-ewqe9edq 149 20 can can MD cord-280130-ewqe9edq 149 21 not not RB cord-280130-ewqe9edq 149 22 block block VB cord-280130-ewqe9edq 149 23 the the DT cord-280130-ewqe9edq 149 24 activation activation NN cord-280130-ewqe9edq 149 25 of of IN cord-280130-ewqe9edq 149 26 PKR PKR NNP cord-280130-ewqe9edq 149 27 in in IN cord-280130-ewqe9edq 149 28 infected infected JJ cord-280130-ewqe9edq 149 29 cells cell NNS cord-280130-ewqe9edq 149 30 Inhibition inhibition NN cord-280130-ewqe9edq 149 31 of of IN cord-280130-ewqe9edq 149 32 PKR PKR NNP cord-280130-ewqe9edq 149 33 by by IN cord-280130-ewqe9edq 149 34 vaccinia vaccinia NN cord-280130-ewqe9edq 149 35 virus virus NN cord-280130-ewqe9edq 149 36 : : : cord-280130-ewqe9edq 150 1 role role NN cord-280130-ewqe9edq 150 2 of of IN cord-280130-ewqe9edq 150 3 the the DT cord-280130-ewqe9edq 150 4 N N NNP cord-280130-ewqe9edq 150 5 - - HYPH cord-280130-ewqe9edq 150 6 and and CC cord-280130-ewqe9edq 150 7 C c NN cord-280130-ewqe9edq 150 8 - - HYPH cord-280130-ewqe9edq 150 9 terminal terminal NN cord-280130-ewqe9edq 150 10 domains domain NNS cord-280130-ewqe9edq 150 11 of of IN cord-280130-ewqe9edq 150 12 E3L e3l NN cord-280130-ewqe9edq 150 13 Binding bind VBG cord-280130-ewqe9edq 150 14 of of IN cord-280130-ewqe9edq 150 15 the the DT cord-280130-ewqe9edq 150 16 influenza influenza NN cord-280130-ewqe9edq 150 17 A a DT cord-280130-ewqe9edq 150 18 virus virus NN cord-280130-ewqe9edq 150 19 NS1 ns1 NN cord-280130-ewqe9edq 150 20 protein protein NN cord-280130-ewqe9edq 150 21 to to IN cord-280130-ewqe9edq 150 22 PKR PKR NNP cord-280130-ewqe9edq 150 23 mediates mediate VBZ cord-280130-ewqe9edq 150 24 the the DT cord-280130-ewqe9edq 150 25 inhibition inhibition NN cord-280130-ewqe9edq 150 26 of of IN cord-280130-ewqe9edq 150 27 its -PRON- PRP$ cord-280130-ewqe9edq 150 28 activation activation NN cord-280130-ewqe9edq 150 29 by by IN cord-280130-ewqe9edq 150 30 either either CC cord-280130-ewqe9edq 150 31 PACT pact NN cord-280130-ewqe9edq 150 32 or or CC cord-280130-ewqe9edq 150 33 double double RB cord-280130-ewqe9edq 150 34 - - HYPH cord-280130-ewqe9edq 150 35 stranded strand VBN cord-280130-ewqe9edq 150 36 RNA RNA NNP cord-280130-ewqe9edq 150 37 Double double RB cord-280130-ewqe9edq 150 38 - - HYPH cord-280130-ewqe9edq 150 39 stranded strand VBN cord-280130-ewqe9edq 150 40 RNA RNA NNP cord-280130-ewqe9edq 150 41 binding bind VBG cord-280130-ewqe9edq 150 42 of of IN cord-280130-ewqe9edq 150 43 influenza influenza NN cord-280130-ewqe9edq 150 44 B b NN cord-280130-ewqe9edq 150 45 virus virus NN cord-280130-ewqe9edq 150 46 nonstructural nonstructural JJ cord-280130-ewqe9edq 150 47 NS1 ns1 NN cord-280130-ewqe9edq 150 48 protein protein NN cord-280130-ewqe9edq 150 49 inhibits inhibit VBZ cord-280130-ewqe9edq 150 50 protein protein NN cord-280130-ewqe9edq 150 51 kinase kinase NN cord-280130-ewqe9edq 150 52 R r NN cord-280130-ewqe9edq 150 53 but but CC cord-280130-ewqe9edq 150 54 is be VBZ cord-280130-ewqe9edq 150 55 not not RB cord-280130-ewqe9edq 150 56 essential essential JJ cord-280130-ewqe9edq 150 57 to to TO cord-280130-ewqe9edq 150 58 antagonize antagonize VB cord-280130-ewqe9edq 150 59 production production NN cord-280130-ewqe9edq 150 60 of of IN cord-280130-ewqe9edq 150 61 alpha alpha NN cord-280130-ewqe9edq 150 62 / / SYM cord-280130-ewqe9edq 150 63 beta beta NN cord-280130-ewqe9edq 150 64 interferon interferon NN cord-280130-ewqe9edq 150 65 Inhibitory inhibitory JJ cord-280130-ewqe9edq 150 66 activity activity NN cord-280130-ewqe9edq 150 67 for for IN cord-280130-ewqe9edq 150 68 the the DT cord-280130-ewqe9edq 150 69 interferon interferon NN cord-280130-ewqe9edq 150 70 - - HYPH cord-280130-ewqe9edq 150 71 induced induce VBN cord-280130-ewqe9edq 150 72 protein protein NN cord-280130-ewqe9edq 150 73 kinase kinase NN cord-280130-ewqe9edq 150 74 is be VBZ cord-280130-ewqe9edq 150 75 associated associate VBN cord-280130-ewqe9edq 150 76 with with IN cord-280130-ewqe9edq 150 77 the the DT cord-280130-ewqe9edq 150 78 reovirus reovirus NNP cord-280130-ewqe9edq 150 79 serotype serotype NNP cord-280130-ewqe9edq 150 80 1 1 CD cord-280130-ewqe9edq 150 81 sigma sigma NNP cord-280130-ewqe9edq 150 82 3 3 CD cord-280130-ewqe9edq 150 83 protein protein NN cord-280130-ewqe9edq 150 84 Inhibition Inhibition NNP cord-280130-ewqe9edq 150 85 of of IN cord-280130-ewqe9edq 150 86 PACT PACT NNP cord-280130-ewqe9edq 150 87 - - HYPH cord-280130-ewqe9edq 150 88 mediated mediate VBN cord-280130-ewqe9edq 150 89 activation activation NN cord-280130-ewqe9edq 150 90 of of IN cord-280130-ewqe9edq 150 91 PKR PKR NNP cord-280130-ewqe9edq 150 92 by by IN cord-280130-ewqe9edq 150 93 the the DT cord-280130-ewqe9edq 150 94 herpes herpes NNP cord-280130-ewqe9edq 150 95 simplex simplex NNP cord-280130-ewqe9edq 150 96 virus virus NN cord-280130-ewqe9edq 150 97 type type NN cord-280130-ewqe9edq 150 98 1 1 CD cord-280130-ewqe9edq 150 99 Us11 Us11 NNP cord-280130-ewqe9edq 150 100 protein protein NN cord-280130-ewqe9edq 150 101 Double Double NNP cord-280130-ewqe9edq 150 102 - - HYPH cord-280130-ewqe9edq 150 103 stranded strand VBN cord-280130-ewqe9edq 150 104 RNA RNA NNP cord-280130-ewqe9edq 150 105 binding bind VBG cord-280130-ewqe9edq 150 106 by by IN cord-280130-ewqe9edq 150 107 human human JJ cord-280130-ewqe9edq 150 108 cytomegalovirus cytomegalovirus NN cord-280130-ewqe9edq 150 109 pTRS1 ptrs1 NN cord-280130-ewqe9edq 151 1 ICP0 ICP0 NNP cord-280130-ewqe9edq 151 2 prevents prevent VBZ cord-280130-ewqe9edq 151 3 RNase RNase NNP cord-280130-ewqe9edq 151 4 L l NN cord-280130-ewqe9edq 151 5 - - HYPH cord-280130-ewqe9edq 151 6 independent independent JJ cord-280130-ewqe9edq 151 7 rRNA rRNA NNP cord-280130-ewqe9edq 151 8 cleavage cleavage NN cord-280130-ewqe9edq 151 9 in in IN cord-280130-ewqe9edq 151 10 herpes herpes NNP cord-280130-ewqe9edq 151 11 simplex simplex NNP cord-280130-ewqe9edq 151 12 virus virus NN cord-280130-ewqe9edq 151 13 type type NN cord-280130-ewqe9edq 151 14 1-infected 1-infected CD cord-280130-ewqe9edq 151 15 cells cell NNS cord-280130-ewqe9edq 152 1 RNase RNase NNP cord-280130-ewqe9edq 152 2 L L NNP cord-280130-ewqe9edq 152 3 inhibitor inhibitor NN cord-280130-ewqe9edq 152 4 is be VBZ cord-280130-ewqe9edq 152 5 induced induce VBN cord-280130-ewqe9edq 152 6 during during IN cord-280130-ewqe9edq 152 7 human human JJ cord-280130-ewqe9edq 152 8 immunodeficiency immunodeficiency NN cord-280130-ewqe9edq 152 9 virus virus NN cord-280130-ewqe9edq 152 10 type type NN cord-280130-ewqe9edq 152 11 1 1 CD cord-280130-ewqe9edq 152 12 infection infection NN cord-280130-ewqe9edq 152 13 and and CC cord-280130-ewqe9edq 152 14 down down RB cord-280130-ewqe9edq 152 15 regulates regulate VBZ cord-280130-ewqe9edq 152 16 the the DT cord-280130-ewqe9edq 152 17 2e5A 2e5a CD cord-280130-ewqe9edq 152 18 / / SYM cord-280130-ewqe9edq 152 19 RNase rnase NN cord-280130-ewqe9edq 152 20 L L NNP cord-280130-ewqe9edq 152 21 pathway pathway NN cord-280130-ewqe9edq 152 22 in in IN cord-280130-ewqe9edq 152 23 human human JJ cord-280130-ewqe9edq 152 24 T t NN cord-280130-ewqe9edq 152 25 cells cell NNS cord-280130-ewqe9edq 152 26 RNase RNase NNP cord-280130-ewqe9edq 152 27 L l NN cord-280130-ewqe9edq 152 28 inhibitor inhibitor NN cord-280130-ewqe9edq 152 29 ( ( -LRB- cord-280130-ewqe9edq 152 30 RLI RLI NNP cord-280130-ewqe9edq 152 31 ) ) -RRB- cord-280130-ewqe9edq 152 32 antisense antisense NN cord-280130-ewqe9edq 152 33 constructions construction NNS cord-280130-ewqe9edq 152 34 block block NN cord-280130-ewqe9edq 152 35 partially partially RB cord-280130-ewqe9edq 152 36 the the DT cord-280130-ewqe9edq 152 37 down down JJ cord-280130-ewqe9edq 152 38 regulation regulation NN cord-280130-ewqe9edq 152 39 of of IN cord-280130-ewqe9edq 152 40 the the DT cord-280130-ewqe9edq 152 41 2e5A/ 2e5a/ CD cord-280130-ewqe9edq 153 1 RNase RNase NNP cord-280130-ewqe9edq 153 2 L L NNP cord-280130-ewqe9edq 153 3 pathway pathway NN cord-280130-ewqe9edq 153 4 in in IN cord-280130-ewqe9edq 153 5 encephalomyocarditis encephalomyocarditis NNP cord-280130-ewqe9edq 153 6 - - HYPH cord-280130-ewqe9edq 153 7 virus-(EMCV)-infected virus-(emcv)-infecte VBN cord-280130-ewqe9edq 153 8 cells cell NNS cord-280130-ewqe9edq 154 1 The the DT cord-280130-ewqe9edq 154 2 gamma(1)34.5 gamma(1)34.5 NNP cord-280130-ewqe9edq 154 3 protein protein NN cord-280130-ewqe9edq 154 4 of of IN cord-280130-ewqe9edq 154 5 herpes herpes NNP cord-280130-ewqe9edq 154 6 simplex simplex NNP cord-280130-ewqe9edq 154 7 virus virus NN cord-280130-ewqe9edq 154 8 1 1 CD cord-280130-ewqe9edq 154 9 complexes complex NNS cord-280130-ewqe9edq 154 10 with with IN cord-280130-ewqe9edq 154 11 protein protein NN cord-280130-ewqe9edq 154 12 phosphatase phosphatase NN cord-280130-ewqe9edq 154 13 1alpha 1alpha CD cord-280130-ewqe9edq 154 14 to to TO cord-280130-ewqe9edq 154 15 dephosphorylate dephosphorylate VB cord-280130-ewqe9edq 154 16 the the DT cord-280130-ewqe9edq 154 17 alpha alpha NN cord-280130-ewqe9edq 154 18 subunit subunit NN cord-280130-ewqe9edq 154 19 of of IN cord-280130-ewqe9edq 154 20 the the DT cord-280130-ewqe9edq 154 21 eukaryotic eukaryotic JJ cord-280130-ewqe9edq 154 22 translation translation NN cord-280130-ewqe9edq 154 23 initiation initiation NN cord-280130-ewqe9edq 154 24 factor factor NN cord-280130-ewqe9edq 154 25 2 2 CD cord-280130-ewqe9edq 154 26 and and CC cord-280130-ewqe9edq 154 27 preclude preclude VB cord-280130-ewqe9edq 154 28 the the DT cord-280130-ewqe9edq 154 29 shutoff shutoff NN cord-280130-ewqe9edq 154 30 of of IN cord-280130-ewqe9edq 154 31 protein protein NN cord-280130-ewqe9edq 154 32 synthesis synthesis NN cord-280130-ewqe9edq 154 33 by by IN cord-280130-ewqe9edq 154 34 double double RB cord-280130-ewqe9edq 154 35 - - HYPH cord-280130-ewqe9edq 154 36 stranded strand VBN cord-280130-ewqe9edq 154 37 RNA RNA NNP cord-280130-ewqe9edq 154 38 - - HYPH cord-280130-ewqe9edq 154 39 activated activate VBN cord-280130-ewqe9edq 154 40 protein protein NN cord-280130-ewqe9edq 154 41 kinase kinase NN cord-280130-ewqe9edq 154 42 Inhibition inhibition NN cord-280130-ewqe9edq 154 43 of of IN cord-280130-ewqe9edq 154 44 the the DT cord-280130-ewqe9edq 154 45 interferon interferon NN cord-280130-ewqe9edq 154 46 - - HYPH cord-280130-ewqe9edq 154 47 inducible inducible JJ cord-280130-ewqe9edq 154 48 protein protein NN cord-280130-ewqe9edq 154 49 kinase kinase VBZ cord-280130-ewqe9edq 154 50 PKR PKR NNP cord-280130-ewqe9edq 154 51 by by IN cord-280130-ewqe9edq 154 52 HCV HCV NNP cord-280130-ewqe9edq 154 53 E2 E2 NNP cord-280130-ewqe9edq 154 54 protein protein NN cord-280130-ewqe9edq 154 55 Control Control NNP cord-280130-ewqe9edq 154 56 of of IN cord-280130-ewqe9edq 154 57 the the DT cord-280130-ewqe9edq 154 58 interferon interferon NN cord-280130-ewqe9edq 154 59 - - HYPH cord-280130-ewqe9edq 154 60 induced induce VBN cord-280130-ewqe9edq 154 61 68-kilodalton 68-kilodalton CD cord-280130-ewqe9edq 154 62 protein protein NN cord-280130-ewqe9edq 154 63 kinase kinase NN cord-280130-ewqe9edq 154 64 by by IN cord-280130-ewqe9edq 154 65 the the DT cord-280130-ewqe9edq 154 66 HIV-1 HIV-1 NNP cord-280130-ewqe9edq 154 67 tat tat NN cord-280130-ewqe9edq 154 68 gene gene NN cord-280130-ewqe9edq 154 69 product product NN cord-280130-ewqe9edq 155 1 The the DT cord-280130-ewqe9edq 155 2 vaccinia vaccinia NN cord-280130-ewqe9edq 155 3 virus virus NN cord-280130-ewqe9edq 155 4 K3L k3l CD cord-280130-ewqe9edq 155 5 gene gene NN cord-280130-ewqe9edq 155 6 product product NN cord-280130-ewqe9edq 155 7 potentiates potentiate VBZ cord-280130-ewqe9edq 155 8 translation translation NN cord-280130-ewqe9edq 155 9 by by IN cord-280130-ewqe9edq 155 10 inhibiting inhibit VBG cord-280130-ewqe9edq 155 11 double double RB cord-280130-ewqe9edq 155 12 - - HYPH cord-280130-ewqe9edq 155 13 stranded stranded JJ cord-280130-ewqe9edq 155 14 - - HYPH cord-280130-ewqe9edq 155 15 RNA rna NN cord-280130-ewqe9edq 155 16 - - HYPH cord-280130-ewqe9edq 155 17 activated activate VBN cord-280130-ewqe9edq 155 18 protein protein NN cord-280130-ewqe9edq 155 19 kinase kinase NN cord-280130-ewqe9edq 155 20 and and CC cord-280130-ewqe9edq 155 21 phosphorylation phosphorylation NN cord-280130-ewqe9edq 155 22 of of IN cord-280130-ewqe9edq 155 23 the the DT cord-280130-ewqe9edq 155 24 alpha alpha NN cord-280130-ewqe9edq 155 25 subunit subunit NN cord-280130-ewqe9edq 155 26 of of IN cord-280130-ewqe9edq 155 27 eukaryotic eukaryotic JJ cord-280130-ewqe9edq 155 28 initiation initiation NN cord-280130-ewqe9edq 155 29 factor factor NN cord-280130-ewqe9edq 155 30 2 2 CD cord-280130-ewqe9edq 155 31 Adenovirus Adenovirus NNP cord-280130-ewqe9edq 155 32 virus virus NN cord-280130-ewqe9edq 155 33 - - HYPH cord-280130-ewqe9edq 155 34 associated associate VBN cord-280130-ewqe9edq 155 35 RNA RNA NNP cord-280130-ewqe9edq 155 36 and and CC cord-280130-ewqe9edq 155 37 translation translation NN cord-280130-ewqe9edq 155 38 control control NN cord-280130-ewqe9edq 155 39 Inhibition inhibition NN cord-280130-ewqe9edq 155 40 of of IN cord-280130-ewqe9edq 155 41 the the DT cord-280130-ewqe9edq 155 42 protein protein NN cord-280130-ewqe9edq 155 43 kinase kinase VBZ cord-280130-ewqe9edq 155 44 PKR PKR NNP cord-280130-ewqe9edq 155 45 by by IN cord-280130-ewqe9edq 155 46 the the DT cord-280130-ewqe9edq 155 47 internal internal JJ cord-280130-ewqe9edq 155 48 ribosome ribosome NN cord-280130-ewqe9edq 155 49 entry entry NN cord-280130-ewqe9edq 155 50 site site NN cord-280130-ewqe9edq 155 51 of of IN cord-280130-ewqe9edq 155 52 hepatitis hepatitis NN cord-280130-ewqe9edq 155 53 C C NNP cord-280130-ewqe9edq 155 54 virus virus NN cord-280130-ewqe9edq 155 55 genomic genomic JJ cord-280130-ewqe9edq 155 56 RNA RNA NNP cord-280130-ewqe9edq 155 57 Regulation Regulation NNP cord-280130-ewqe9edq 155 58 of of IN cord-280130-ewqe9edq 155 59 the the DT cord-280130-ewqe9edq 155 60 double double RB cord-280130-ewqe9edq 155 61 - - HYPH cord-280130-ewqe9edq 155 62 stranded strand VBN cord-280130-ewqe9edq 155 63 RNA rna NN cord-280130-ewqe9edq 155 64 - - HYPH cord-280130-ewqe9edq 155 65 dependent dependent JJ cord-280130-ewqe9edq 155 66 protein protein NN cord-280130-ewqe9edq 155 67 kinase kinase VBZ cord-280130-ewqe9edq 155 68 PKR PKR NNP cord-280130-ewqe9edq 155 69 by by IN cord-280130-ewqe9edq 155 70 RNAs rna NNS cord-280130-ewqe9edq 155 71 encoded encode VBN cord-280130-ewqe9edq 155 72 by by IN cord-280130-ewqe9edq 155 73 a a DT cord-280130-ewqe9edq 155 74 repeated repeat VBN cord-280130-ewqe9edq 155 75 sequence sequence NN cord-280130-ewqe9edq 155 76 in in IN cord-280130-ewqe9edq 155 77 the the DT cord-280130-ewqe9edq 155 78 EpsteineBarr EpsteineBarr NNP cord-280130-ewqe9edq 155 79 virus virus NN cord-280130-ewqe9edq 156 1 genome genome NN cord-280130-ewqe9edq 156 2 Tat tat NN cord-280130-ewqe9edq 156 3 - - HYPH cord-280130-ewqe9edq 156 4 responsive responsive JJ cord-280130-ewqe9edq 156 5 region region NN cord-280130-ewqe9edq 156 6 RNA RNA NNP cord-280130-ewqe9edq 156 7 of of IN cord-280130-ewqe9edq 156 8 human human JJ cord-280130-ewqe9edq 156 9 immunodeficiency immunodeficiency NN cord-280130-ewqe9edq 156 10 virus virus NN cord-280130-ewqe9edq 156 11 1 1 CD cord-280130-ewqe9edq 156 12 can can MD cord-280130-ewqe9edq 156 13 prevent prevent VB cord-280130-ewqe9edq 156 14 activation activation NN cord-280130-ewqe9edq 156 15 of of IN cord-280130-ewqe9edq 156 16 the the DT cord-280130-ewqe9edq 156 17 double double RB cord-280130-ewqe9edq 156 18 - - HYPH cord-280130-ewqe9edq 156 19 stranded stranded JJ cord-280130-ewqe9edq 156 20 - - HYPH cord-280130-ewqe9edq 156 21 RNA rna NN cord-280130-ewqe9edq 156 22 - - HYPH cord-280130-ewqe9edq 156 23 activated activate VBN cord-280130-ewqe9edq 156 24 protein protein NN cord-280130-ewqe9edq 156 25 kinase kinase NN cord-280130-ewqe9edq 156 26 Protection Protection NNP cord-280130-ewqe9edq 156 27 from from IN cord-280130-ewqe9edq 156 28 interferon interferon NN cord-280130-ewqe9edq 156 29 - - HYPH cord-280130-ewqe9edq 156 30 induced induce VBN cord-280130-ewqe9edq 156 31 apoptosis apoptosis NN cord-280130-ewqe9edq 156 32 by by IN cord-280130-ewqe9edq 156 33 EpsteineBarr EpsteineBarr NNP cord-280130-ewqe9edq 156 34 virus virus NN cord-280130-ewqe9edq 157 1 small small JJ cord-280130-ewqe9edq 157 2 RNAs rna NNS cord-280130-ewqe9edq 157 3 is be VBZ cord-280130-ewqe9edq 157 4 not not RB cord-280130-ewqe9edq 157 5 mediated mediate VBN cord-280130-ewqe9edq 157 6 by by IN cord-280130-ewqe9edq 157 7 inhibition inhibition NN cord-280130-ewqe9edq 157 8 of of IN cord-280130-ewqe9edq 157 9 PKR PKR NNP cord-280130-ewqe9edq 157 10 Interferons interferon NNS cord-280130-ewqe9edq 157 11 : : : cord-280130-ewqe9edq 157 12 cell cell NN cord-280130-ewqe9edq 157 13 signalling signalling NN cord-280130-ewqe9edq 157 14 , , , cord-280130-ewqe9edq 157 15 immune immune JJ cord-280130-ewqe9edq 157 16 modulation modulation NN cord-280130-ewqe9edq 157 17 , , , cord-280130-ewqe9edq 157 18 antiviral antiviral JJ cord-280130-ewqe9edq 157 19 response response NN cord-280130-ewqe9edq 157 20 and and CC cord-280130-ewqe9edq 157 21 virus virus NN cord-280130-ewqe9edq 157 22 countermeasures countermeasure NNS cord-280130-ewqe9edq 158 1 The the DT cord-280130-ewqe9edq 158 2 Ebola Ebola NNP cord-280130-ewqe9edq 158 3 virus virus NN cord-280130-ewqe9edq 158 4 VP35 VP35 NNP cord-280130-ewqe9edq 158 5 protein protein NN cord-280130-ewqe9edq 158 6 inhibits inhibit VBZ cord-280130-ewqe9edq 158 7 activation activation NN cord-280130-ewqe9edq 158 8 of of IN cord-280130-ewqe9edq 158 9 interferon interferon NN cord-280130-ewqe9edq 158 10 regulatory regulatory JJ cord-280130-ewqe9edq 158 11 factor factor NN cord-280130-ewqe9edq 158 12 3 3 CD cord-280130-ewqe9edq 158 13 Thogoto Thogoto NNP cord-280130-ewqe9edq 158 14 virus virus NN cord-280130-ewqe9edq 158 15 lacking lack VBG cord-280130-ewqe9edq 158 16 interferon interferon NN cord-280130-ewqe9edq 158 17 - - HYPH cord-280130-ewqe9edq 158 18 antagonistic antagonistic JJ cord-280130-ewqe9edq 158 19 protein protein NN cord-280130-ewqe9edq 158 20 ML ML NNP cord-280130-ewqe9edq 158 21 is be VBZ cord-280130-ewqe9edq 158 22 strongly strongly RB cord-280130-ewqe9edq 158 23 attenuated attenuate VBN cord-280130-ewqe9edq 158 24 in in IN cord-280130-ewqe9edq 158 25 newborn newborn JJ cord-280130-ewqe9edq 158 26 Mx1-positive Mx1-positive NNP cord-280130-ewqe9edq 159 1 but but CC cord-280130-ewqe9edq 159 2 not not RB cord-280130-ewqe9edq 159 3 Mx1-negative Mx1-negative NNP cord-280130-ewqe9edq 159 4 mice mouse NNS cord-280130-ewqe9edq 159 5 Inhibition inhibition NN cord-280130-ewqe9edq 159 6 of of IN cord-280130-ewqe9edq 159 7 the the DT cord-280130-ewqe9edq 159 8 type type NN cord-280130-ewqe9edq 160 1 I -PRON- PRP cord-280130-ewqe9edq 161 1 interferon interferon NNP cord-280130-ewqe9edq 161 2 response response NN cord-280130-ewqe9edq 161 3 by by IN cord-280130-ewqe9edq 161 4 the the DT cord-280130-ewqe9edq 161 5 nucleoprotein nucleoprotein NNP cord-280130-ewqe9edq 161 6 of of IN cord-280130-ewqe9edq 161 7 the the DT cord-280130-ewqe9edq 161 8 prototypic prototypic NNP cord-280130-ewqe9edq 161 9 arenavirus arenavirus NNP cord-280130-ewqe9edq 161 10 lymphocytic lymphocytic NNP cord-280130-ewqe9edq 161 11 choriomeningitis choriomeningitis NNP cord-280130-ewqe9edq 161 12 virus virus NN cord-280130-ewqe9edq 161 13 Sars Sars NNP cord-280130-ewqe9edq 161 14 coronavirus coronavirus NN cord-280130-ewqe9edq 161 15 proteins protein VBZ cord-280130-ewqe9edq 161 16 Orf Orf NNP cord-280130-ewqe9edq 161 17 3b 3b CD cord-280130-ewqe9edq 161 18 , , , cord-280130-ewqe9edq 161 19 Orf Orf NNP cord-280130-ewqe9edq 161 20 6 6 CD cord-280130-ewqe9edq 161 21 , , , cord-280130-ewqe9edq 161 22 and and CC cord-280130-ewqe9edq 161 23 nucleocapsid nucleocapsid NN cord-280130-ewqe9edq 161 24 function function VB cord-280130-ewqe9edq 161 25 as as IN cord-280130-ewqe9edq 161 26 interferon interferon NN cord-280130-ewqe9edq 161 27 antagonists antagonist NNS cord-280130-ewqe9edq 161 28 Inhibition Inhibition NNP cord-280130-ewqe9edq 161 29 of of IN cord-280130-ewqe9edq 161 30 interferon interferon NN cord-280130-ewqe9edq 161 31 signaling signal VBG cord-280130-ewqe9edq 161 32 by by IN cord-280130-ewqe9edq 161 33 dengue dengue NN cord-280130-ewqe9edq 161 34 virus virus NN cord-280130-ewqe9edq 161 35 Inhibition inhibition NN cord-280130-ewqe9edq 161 36 of of IN cord-280130-ewqe9edq 161 37 Beta Beta NNP cord-280130-ewqe9edq 161 38 interferon interferon NN cord-280130-ewqe9edq 161 39 induction induction NN cord-280130-ewqe9edq 161 40 by by IN cord-280130-ewqe9edq 161 41 severe severe JJ cord-280130-ewqe9edq 161 42 acute acute JJ cord-280130-ewqe9edq 161 43 respiratory respiratory JJ cord-280130-ewqe9edq 161 44 syndrome syndrome NN cord-280130-ewqe9edq 161 45 coronavirus coronavirus NN cord-280130-ewqe9edq 161 46 suggests suggest VBZ cord-280130-ewqe9edq 161 47 a a DT cord-280130-ewqe9edq 161 48 two two CD cord-280130-ewqe9edq 161 49 - - HYPH cord-280130-ewqe9edq 161 50 step step NN cord-280130-ewqe9edq 161 51 model model NN cord-280130-ewqe9edq 161 52 for for IN cord-280130-ewqe9edq 161 53 activation activation NN cord-280130-ewqe9edq 161 54 of of IN cord-280130-ewqe9edq 161 55 interferon interferon NN cord-280130-ewqe9edq 161 56 regulatory regulatory JJ cord-280130-ewqe9edq 161 57 factor factor NN cord-280130-ewqe9edq 161 58 3 3 CD cord-280130-ewqe9edq 161 59 Immunogenicity Immunogenicity NNP cord-280130-ewqe9edq 161 60 and and CC cord-280130-ewqe9edq 161 61 protection protection NN cord-280130-ewqe9edq 161 62 efficacy efficacy NN cord-280130-ewqe9edq 161 63 of of IN cord-280130-ewqe9edq 161 64 replication replication NN cord-280130-ewqe9edq 161 65 - - HYPH cord-280130-ewqe9edq 161 66 deficient deficient JJ cord-280130-ewqe9edq 161 67 influenza influenza NN cord-280130-ewqe9edq 161 68 A a DT cord-280130-ewqe9edq 161 69 viruses virus NNS cord-280130-ewqe9edq 161 70 with with IN cord-280130-ewqe9edq 161 71 altered alter VBN cord-280130-ewqe9edq 161 72 NS1 ns1 NN cord-280130-ewqe9edq 161 73 genes gene NNS cord-280130-ewqe9edq 161 74 Influenza Influenza NNP cord-280130-ewqe9edq 161 75 virus virus NN cord-280130-ewqe9edq 161 76 evades evade VBZ cord-280130-ewqe9edq 161 77 innate innate JJ cord-280130-ewqe9edq 161 78 and and CC cord-280130-ewqe9edq 161 79 adaptive adaptive JJ cord-280130-ewqe9edq 161 80 immunity immunity NN cord-280130-ewqe9edq 161 81 via via IN cord-280130-ewqe9edq 161 82 the the DT cord-280130-ewqe9edq 161 83 NS1 ns1 NN cord-280130-ewqe9edq 161 84 protein protein NN cord-280130-ewqe9edq 161 85 Vaccination vaccination NN cord-280130-ewqe9edq 161 86 of of IN cord-280130-ewqe9edq 161 87 pigs pig NNS cord-280130-ewqe9edq 161 88 against against IN cord-280130-ewqe9edq 161 89 swine swine NN cord-280130-ewqe9edq 161 90 influenza influenza NN cord-280130-ewqe9edq 161 91 viruses virus NNS cord-280130-ewqe9edq 161 92 by by IN cord-280130-ewqe9edq 161 93 using use VBG cord-280130-ewqe9edq 161 94 an an DT cord-280130-ewqe9edq 161 95 NS1-truncated ns1-truncate VBN cord-280130-ewqe9edq 161 96 modified modify VBN cord-280130-ewqe9edq 161 97 live live NN cord-280130-ewqe9edq 161 98 - - HYPH cord-280130-ewqe9edq 161 99 virus virus NN cord-280130-ewqe9edq 161 100 vaccine vaccine NN cord-280130-ewqe9edq 161 101 Influenza Influenza NNP cord-280130-ewqe9edq 161 102 A A NNP cord-280130-ewqe9edq 161 103 and and CC cord-280130-ewqe9edq 161 104 B b NN cord-280130-ewqe9edq 161 105 viruses virus NNS cord-280130-ewqe9edq 161 106 expressing express VBG cord-280130-ewqe9edq 161 107 altered alter VBN cord-280130-ewqe9edq 161 108 NS1 ns1 NN cord-280130-ewqe9edq 161 109 proteins protein NNS cord-280130-ewqe9edq 161 110 : : : cord-280130-ewqe9edq 161 111 A a DT cord-280130-ewqe9edq 161 112 vaccine vaccine NN cord-280130-ewqe9edq 161 113 approach approach NN cord-280130-ewqe9edq 161 114 Attenuating Attenuating NNP cord-280130-ewqe9edq 161 115 mutations mutation NNS cord-280130-ewqe9edq 161 116 in in IN cord-280130-ewqe9edq 161 117 the the DT cord-280130-ewqe9edq 161 118 P p NN cord-280130-ewqe9edq 161 119 / / SYM cord-280130-ewqe9edq 161 120 C C NNP cord-280130-ewqe9edq 161 121 gene gene NN cord-280130-ewqe9edq 161 122 of of IN cord-280130-ewqe9edq 161 123 human human NNP cord-280130-ewqe9edq 161 124 parainfluenza parainfluenza NNP cord-280130-ewqe9edq 161 125 virus virus NNP cord-280130-ewqe9edq 161 126 type type NNP cord-280130-ewqe9edq 161 127 1 1 CD cord-280130-ewqe9edq 162 1 ( ( -LRB- cord-280130-ewqe9edq 162 2 HPIV1 HPIV1 NNP cord-280130-ewqe9edq 162 3 ) ) -RRB- cord-280130-ewqe9edq 162 4 vaccine vaccine NN cord-280130-ewqe9edq 162 5 candidates candidate NNS cord-280130-ewqe9edq 162 6 abrogate abrogate VBP cord-280130-ewqe9edq 162 7 the the DT cord-280130-ewqe9edq 162 8 inhibition inhibition NN cord-280130-ewqe9edq 162 9 of of IN cord-280130-ewqe9edq 162 10 both both DT cord-280130-ewqe9edq 162 11 induction induction NN cord-280130-ewqe9edq 162 12 and and CC cord-280130-ewqe9edq 162 13 signaling signaling NN cord-280130-ewqe9edq 162 14 of of IN cord-280130-ewqe9edq 162 15 type type NN cord-280130-ewqe9edq 163 1 I -PRON- PRP cord-280130-ewqe9edq 163 2 interferon interferon NN cord-280130-ewqe9edq 163 3 ( ( -LRB- cord-280130-ewqe9edq 163 4 IFN IFN NNP cord-280130-ewqe9edq 163 5 ) ) -RRB- cord-280130-ewqe9edq 163 6 by by IN cord-280130-ewqe9edq 163 7 wild wild JJ cord-280130-ewqe9edq 163 8 - - HYPH cord-280130-ewqe9edq 163 9 type type NN cord-280130-ewqe9edq 163 10 HPIV1 HPIV1 NNP cord-280130-ewqe9edq 163 11 Role role NN cord-280130-ewqe9edq 163 12 of of IN cord-280130-ewqe9edq 163 13 alpha alpha NN cord-280130-ewqe9edq 163 14 / / SYM cord-280130-ewqe9edq 163 15 beta beta NN cord-280130-ewqe9edq 163 16 interferons interferon NNS cord-280130-ewqe9edq 163 17 in in IN cord-280130-ewqe9edq 163 18 the the DT cord-280130-ewqe9edq 163 19 attenuation attenuation NN cord-280130-ewqe9edq 163 20 and and CC cord-280130-ewqe9edq 163 21 immunogenicity immunogenicity NN cord-280130-ewqe9edq 163 22 of of IN cord-280130-ewqe9edq 163 23 recombinant recombinant JJ cord-280130-ewqe9edq 163 24 bovine bovine JJ cord-280130-ewqe9edq 163 25 respiratory respiratory JJ cord-280130-ewqe9edq 163 26 syncytial syncytial JJ cord-280130-ewqe9edq 163 27 viruses virus NNS cord-280130-ewqe9edq 163 28 lacking lack VBG cord-280130-ewqe9edq 163 29 NS NS NNP cord-280130-ewqe9edq 163 30 proteins protein NNS cord-280130-ewqe9edq 164 1 The the DT cord-280130-ewqe9edq 164 2 interferon interferon NN cord-280130-ewqe9edq 164 3 antagonist antagonist NN cord-280130-ewqe9edq 164 4 NS2 NS2 NNP cord-280130-ewqe9edq 164 5 protein protein NN cord-280130-ewqe9edq 164 6 of of IN cord-280130-ewqe9edq 164 7 respiratory respiratory JJ cord-280130-ewqe9edq 164 8 syncytial syncytial JJ cord-280130-ewqe9edq 164 9 virus virus NN cord-280130-ewqe9edq 164 10 is be VBZ cord-280130-ewqe9edq 164 11 an an DT cord-280130-ewqe9edq 164 12 important important JJ cord-280130-ewqe9edq 164 13 virulence virulence NN cord-280130-ewqe9edq 164 14 determinant determinant NN cord-280130-ewqe9edq 164 15 for for IN cord-280130-ewqe9edq 164 16 humans human NNS cord-280130-ewqe9edq 165 1 Recombinant recombinant JJ cord-280130-ewqe9edq 165 2 respiratory respiratory JJ cord-280130-ewqe9edq 165 3 syncytial syncytial JJ cord-280130-ewqe9edq 165 4 virus virus NN cord-280130-ewqe9edq 165 5 that that WDT cord-280130-ewqe9edq 165 6 does do VBZ cord-280130-ewqe9edq 165 7 not not RB cord-280130-ewqe9edq 165 8 express express VB cord-280130-ewqe9edq 165 9 the the DT cord-280130-ewqe9edq 165 10 NS1 ns1 NN cord-280130-ewqe9edq 165 11 or or CC cord-280130-ewqe9edq 165 12 M2 m2 JJ cord-280130-ewqe9edq 165 13 - - SYM cord-280130-ewqe9edq 165 14 2 2 CD cord-280130-ewqe9edq 165 15 protein protein NN cord-280130-ewqe9edq 165 16 is be VBZ cord-280130-ewqe9edq 165 17 highly highly RB cord-280130-ewqe9edq 165 18 attenuated attenuated JJ cord-280130-ewqe9edq 165 19 and and CC cord-280130-ewqe9edq 165 20 immunogenic immunogenic JJ cord-280130-ewqe9edq 165 21 in in IN cord-280130-ewqe9edq 165 22 chimpanzees chimpanzee NNS cord-280130-ewqe9edq 166 1 Negative negative JJ cord-280130-ewqe9edq 166 2 regulation regulation NN cord-280130-ewqe9edq 166 3 of of IN cord-280130-ewqe9edq 166 4 the the DT cord-280130-ewqe9edq 166 5 alpha alpha NN cord-280130-ewqe9edq 166 6 interferon interferon NN cord-280130-ewqe9edq 166 7 - - HYPH cord-280130-ewqe9edq 166 8 induced induce VBN cord-280130-ewqe9edq 166 9 antiviral antiviral JJ cord-280130-ewqe9edq 166 10 response response NN cord-280130-ewqe9edq 166 11 by by IN cord-280130-ewqe9edq 166 12 the the DT cord-280130-ewqe9edq 166 13 Ras Ras NNP cord-280130-ewqe9edq 166 14 / / SYM cord-280130-ewqe9edq 166 15 Raf Raf NNP cord-280130-ewqe9edq 166 16 / / SYM cord-280130-ewqe9edq 166 17 MEK MEK NNP cord-280130-ewqe9edq 166 18 pathway pathway NN cord-280130-ewqe9edq 167 1 Differentially differentially RB cord-280130-ewqe9edq 167 2 regulated regulate VBN cord-280130-ewqe9edq 167 3 interferon interferon NN cord-280130-ewqe9edq 167 4 response response NN cord-280130-ewqe9edq 167 5 determines determine VBZ cord-280130-ewqe9edq 167 6 the the DT cord-280130-ewqe9edq 167 7 outcome outcome NN cord-280130-ewqe9edq 167 8 of of IN cord-280130-ewqe9edq 167 9 Newcastle Newcastle NNP cord-280130-ewqe9edq 167 10 disease disease NN cord-280130-ewqe9edq 167 11 virus virus NN cord-280130-ewqe9edq 167 12 infection infection NN cord-280130-ewqe9edq 167 13 in in IN cord-280130-ewqe9edq 167 14 normal normal JJ cord-280130-ewqe9edq 167 15 and and CC cord-280130-ewqe9edq 167 16 tumor tumor NN cord-280130-ewqe9edq 167 17 cell cell NN cord-280130-ewqe9edq 167 18 lines line NNS cord-280130-ewqe9edq 167 19 Exploiting exploit VBG cord-280130-ewqe9edq 167 20 tumor tumor NN cord-280130-ewqe9edq 167 21 - - HYPH cord-280130-ewqe9edq 167 22 specific specific JJ cord-280130-ewqe9edq 167 23 defects defect NNS cord-280130-ewqe9edq 167 24 in in IN cord-280130-ewqe9edq 167 25 the the DT cord-280130-ewqe9edq 167 26 interferon interferon NN cord-280130-ewqe9edq 167 27 pathway pathway NN cord-280130-ewqe9edq 167 28 with with IN cord-280130-ewqe9edq 167 29 a a DT cord-280130-ewqe9edq 167 30 previously previously RB cord-280130-ewqe9edq 167 31 unknown unknown JJ cord-280130-ewqe9edq 167 32 oncolytic oncolytic JJ cord-280130-ewqe9edq 167 33 virus virus NN cord-280130-ewqe9edq 168 1 The the DT cord-280130-ewqe9edq 168 2 molecular molecular JJ cord-280130-ewqe9edq 168 3 basis basis NN cord-280130-ewqe9edq 168 4 of of IN cord-280130-ewqe9edq 168 5 viral viral JJ cord-280130-ewqe9edq 168 6 oncolysis oncolysis NN cord-280130-ewqe9edq 168 7 : : : cord-280130-ewqe9edq 168 8 usurpation usurpation NN cord-280130-ewqe9edq 168 9 of of IN cord-280130-ewqe9edq 168 10 the the DT cord-280130-ewqe9edq 168 11 Ras Ras NNP cord-280130-ewqe9edq 168 12 signaling signal VBG cord-280130-ewqe9edq 168 13 pathway pathway NN cord-280130-ewqe9edq 168 14 by by IN cord-280130-ewqe9edq 168 15 reovirus reovirus NNP cord-280130-ewqe9edq 168 16 Defective defective JJ cord-280130-ewqe9edq 168 17 translational translational JJ cord-280130-ewqe9edq 168 18 control control NN cord-280130-ewqe9edq 168 19 facilitates facilitate VBZ cord-280130-ewqe9edq 168 20 vesicular vesicular JJ cord-280130-ewqe9edq 168 21 stomatitis stomatitis NN cord-280130-ewqe9edq 168 22 virus virus NN cord-280130-ewqe9edq 168 23 oncolysis oncolysis NNP cord-280130-ewqe9edq 168 24 Reovirus Reovirus NNP cord-280130-ewqe9edq 168 25 therapy therapy NN cord-280130-ewqe9edq 168 26 of of IN cord-280130-ewqe9edq 168 27 tumors tumor NNS cord-280130-ewqe9edq 168 28 with with IN cord-280130-ewqe9edq 169 1 activated activate VBN cord-280130-ewqe9edq 169 2 Ras Ras NNP cord-280130-ewqe9edq 169 3 pathway pathway NN cord-280130-ewqe9edq 169 4 Attenuated attenuate VBN cord-280130-ewqe9edq 169 5 , , , cord-280130-ewqe9edq 169 6 replication replication NN cord-280130-ewqe9edq 169 7 - - HYPH cord-280130-ewqe9edq 169 8 competent competent JJ cord-280130-ewqe9edq 169 9 herpes herpes NN cord-280130-ewqe9edq 169 10 simplex simplex NN cord-280130-ewqe9edq 169 11 virus virus NN cord-280130-ewqe9edq 169 12 type type NN cord-280130-ewqe9edq 169 13 1 1 CD cord-280130-ewqe9edq 169 14 mutant mutant JJ cord-280130-ewqe9edq 169 15 G207 g207 NN cord-280130-ewqe9edq 169 16 : : : cord-280130-ewqe9edq 169 17 safety safety NN cord-280130-ewqe9edq 169 18 evaluation evaluation NN cord-280130-ewqe9edq 169 19 of of IN cord-280130-ewqe9edq 169 20 intracerebral intracerebral JJ cord-280130-ewqe9edq 169 21 injection injection NN cord-280130-ewqe9edq 169 22 in in IN cord-280130-ewqe9edq 169 23 nonhuman nonhuman NN cord-280130-ewqe9edq 169 24 primates primate NNS cord-280130-ewqe9edq 170 1 Attenuated attenuated JJ cord-280130-ewqe9edq 170 2 multi multi JJ cord-280130-ewqe9edq 170 3 - - JJ cord-280130-ewqe9edq 170 4 mutated mutated JJ cord-280130-ewqe9edq 170 5 herpes herpes NN cord-280130-ewqe9edq 170 6 simplex simplex NN cord-280130-ewqe9edq 170 7 virus-1 virus-1 NN cord-280130-ewqe9edq 170 8 for for IN cord-280130-ewqe9edq 170 9 the the DT cord-280130-ewqe9edq 170 10 treatment treatment NN cord-280130-ewqe9edq 170 11 of of IN cord-280130-ewqe9edq 170 12 malignant malignant JJ cord-280130-ewqe9edq 170 13 gliomas glioma NNS cord-280130-ewqe9edq 171 1 Our -PRON- PRP$ cord-280130-ewqe9edq 171 2 own own JJ cord-280130-ewqe9edq 171 3 work work NN cord-280130-ewqe9edq 171 4 described describe VBN cord-280130-ewqe9edq 171 5 in in IN cord-280130-ewqe9edq 171 6 the the DT cord-280130-ewqe9edq 171 7 text text NN cord-280130-ewqe9edq 171 8 was be VBD cord-280130-ewqe9edq 171 9 supported support VBN cord-280130-ewqe9edq 171 10 by by IN cord-280130-ewqe9edq 171 11 grants grant NNS cord-280130-ewqe9edq 171 12 from from IN cord-280130-ewqe9edq 171 13 the the DT cord-280130-ewqe9edq 171 14 Deutsche Deutsche NNP cord-280130-ewqe9edq 171 15 Forschungsgemeinschaft Forschungsgemeinschaft NNP cord-280130-ewqe9edq 171 16 . . .