id	sid	tid	token	lemma	pos
cord-265941-eff4le0g	1	1	key	key	NN
cord-265941-eff4le0g	1	2	:	:	:
cord-265941-eff4le0g	2	1	cord-265941-eff4le0	cord-265941-eff4le0	NNP
cord-265941-eff4le0g	2	2	g	g	NN
cord-265941-eff4le0g	2	3	authors	author	NNS
cord-265941-eff4le0g	2	4	:	:	:
cord-265941-eff4le0g	2	5	Eng	Eng	NNP
cord-265941-eff4le0g	2	6	,	,	,
cord-265941-eff4le0g	2	7	Vik	Vik	NNP
cord-265941-eff4le0g	2	8	Ven	Ven	NNP
cord-265941-eff4le0g	2	9	;	;	:
cord-265941-eff4le0g	2	10	Wemyss	Wemyss	NNP
cord-265941-eff4le0g	2	11	,	,	,
cord-265941-eff4le0g	2	12	Madeleine	Madeleine	NNP
cord-265941-eff4le0g	2	13	A.	A.	NNP
cord-265941-eff4le0g	2	14	;	;	:
cord-265941-eff4le0g	2	15	Pearson	Pearson	NNP
cord-265941-eff4le0g	2	16	,	,	,
cord-265941-eff4le0g	2	17	Jaclyn	Jaclyn	NNP
cord-265941-eff4le0g	2	18	S.	S.	NNP
cord-265941-eff4le0g	3	1	title	title	NN
cord-265941-eff4le0g	3	2	:	:	:
cord-265941-eff4le0g	4	1	The	the	DT
cord-265941-eff4le0g	4	2	diverse	diverse	JJ
cord-265941-eff4le0g	4	3	roles	role	NNS
cord-265941-eff4le0g	4	4	of	of	IN
cord-265941-eff4le0g	4	5	RIP	rip	NN
cord-265941-eff4le0g	4	6	kinases	kinase	NNS
cord-265941-eff4le0g	4	7	in	in	IN
cord-265941-eff4le0g	4	8	host	host	NN
cord-265941-eff4le0g	4	9	-	-	HYPH
cord-265941-eff4le0g	4	10	pathogen	pathogen	NN
cord-265941-eff4le0g	4	11	interactions	interaction	NNS
cord-265941-eff4le0g	4	12	date	date	NN
cord-265941-eff4le0g	4	13	:	:	:
cord-265941-eff4le0g	4	14	2020	2020	CD
cord-265941-eff4le0g	4	15	-	-	HYPH
cord-265941-eff4le0g	4	16	08	08	CD
cord-265941-eff4le0g	4	17	-	-	SYM
cord-265941-eff4le0g	4	18	26	26	CD
cord-265941-eff4le0g	4	19	journal	journal	NN
cord-265941-eff4le0g	4	20	:	:	:
cord-265941-eff4le0g	4	21	Semin	Semin	NNP
cord-265941-eff4le0g	4	22	Cell	Cell	NNP
cord-265941-eff4le0g	4	23	Dev	Dev	NNP
cord-265941-eff4le0g	4	24	Biol	Biol	NNP
cord-265941-eff4le0g	4	25	DOI	DOI	NNP
cord-265941-eff4le0g	4	26	:	:	:
cord-265941-eff4le0g	5	1	10.1016	10.1016	CD
cord-265941-eff4le0g	5	2	/	/	SYM
cord-265941-eff4le0g	5	3	j.semcdb.2020.08.005	j.semcdb.2020.08.005	CD
cord-265941-eff4le0g	5	4	sha	sha	NNP
cord-265941-eff4le0g	5	5	:	:	:
cord-265941-eff4le0g	6	1	e7c03d4f78b1f8f5eb60727f7f26aa9a0009da70	e7c03d4f78b1f8f5eb60727f7f26aa9a0009da70	RB
cord-265941-eff4le0g	7	1	doc_id	doc_id	CD
cord-265941-eff4le0g	7	2	:	:	:
cord-265941-eff4le0g	7	3	265941	265941	CD
cord-265941-eff4le0g	7	4	cord_uid	cord_uid	NNS
cord-265941-eff4le0g	7	5	:	:	:
cord-265941-eff4le0g	8	1	eff4le0	eff4le0	NNP
cord-265941-eff4le0g	8	2	g	g	NNP
cord-265941-eff4le0g	8	3	Receptor	Receptor	NNP
cord-265941-eff4le0g	8	4	Interacting	interact	VBG
cord-265941-eff4le0g	8	5	Protein	Protein	NNP
cord-265941-eff4le0g	8	6	Kinases	Kinases	NNP
cord-265941-eff4le0g	8	7	(	(	-LRB-
cord-265941-eff4le0g	8	8	RIPKs	ripks	NN
cord-265941-eff4le0g	8	9	)	)	-RRB-
cord-265941-eff4le0g	8	10	are	be	VBP
cord-265941-eff4le0g	8	11	cellular	cellular	JJ
cord-265941-eff4le0g	8	12	signaling	signal	VBG
cord-265941-eff4le0g	8	13	molecules	molecule	NNS
cord-265941-eff4le0g	8	14	that	that	WDT
cord-265941-eff4le0g	8	15	are	be	VBP
cord-265941-eff4le0g	8	16	critical	critical	JJ
cord-265941-eff4le0g	8	17	for	for	IN
cord-265941-eff4le0g	8	18	homeostatic	homeostatic	JJ
cord-265941-eff4le0g	8	19	signaling	signaling	NN
cord-265941-eff4le0g	8	20	in	in	IN
cord-265941-eff4le0g	8	21	both	both	CC
cord-265941-eff4le0g	8	22	communicable	communicable	JJ
cord-265941-eff4le0g	8	23	and	and	CC
cord-265941-eff4le0g	8	24	non	non	JJ
cord-265941-eff4le0g	8	25	-	-	JJ
cord-265941-eff4le0g	8	26	communicable	communicable	JJ
cord-265941-eff4le0g	8	27	disease	disease	NN
cord-265941-eff4le0g	8	28	processes	process	NNS
cord-265941-eff4le0g	8	29	.	.	.
cord-265941-eff4le0g	9	1	In	in	IN
cord-265941-eff4le0g	9	2	particular	particular	JJ
cord-265941-eff4le0g	9	3	,	,	,
cord-265941-eff4le0g	9	4	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	9	5	,	,	,
cord-265941-eff4le0g	9	6	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	9	7	,	,	,
cord-265941-eff4le0g	9	8	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	9	9	and	and	CC
cord-265941-eff4le0g	9	10	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	9	11	have	have	VBP
cord-265941-eff4le0g	9	12	emerged	emerge	VBN
cord-265941-eff4le0g	9	13	as	as	IN
cord-265941-eff4le0g	9	14	key	key	JJ
cord-265941-eff4le0g	9	15	mediators	mediator	NNS
cord-265941-eff4le0g	9	16	of	of	IN
cord-265941-eff4le0g	9	17	intracellular	intracellular	JJ
cord-265941-eff4le0g	9	18	signal	signal	NN
cord-265941-eff4le0g	9	19	transduction	transduction	NN
cord-265941-eff4le0g	9	20	including	include	VBG
cord-265941-eff4le0g	9	21	inflammation	inflammation	NN
cord-265941-eff4le0g	9	22	,	,	,
cord-265941-eff4le0g	9	23	autophagy	autophagy	NN
cord-265941-eff4le0g	9	24	and	and	CC
cord-265941-eff4le0g	9	25	programmed	programmed	JJ
cord-265941-eff4le0g	9	26	cell	cell	NN
cord-265941-eff4le0g	9	27	death	death	NN
cord-265941-eff4le0g	9	28	,	,	,
cord-265941-eff4le0g	9	29	and	and	CC
cord-265941-eff4le0g	9	30	are	be	VBP
cord-265941-eff4le0g	9	31	thus	thus	RB
cord-265941-eff4le0g	9	32	essential	essential	JJ
cord-265941-eff4le0g	9	33	for	for	IN
cord-265941-eff4le0g	9	34	the	the	DT
cord-265941-eff4le0g	9	35	early	early	JJ
cord-265941-eff4le0g	9	36	control	control	NN
cord-265941-eff4le0g	9	37	of	of	IN
cord-265941-eff4le0g	9	38	many	many	JJ
cord-265941-eff4le0g	9	39	diverse	diverse	JJ
cord-265941-eff4le0g	9	40	pathogenic	pathogenic	JJ
cord-265941-eff4le0g	9	41	organisms	organism	NNS
cord-265941-eff4le0g	9	42	.	.	.
cord-265941-eff4le0g	10	1	In	in	IN
cord-265941-eff4le0g	10	2	this	this	DT
cord-265941-eff4le0g	10	3	review	review	NN
cord-265941-eff4le0g	10	4	,	,	,
cord-265941-eff4le0g	10	5	we	-PRON-	PRP
cord-265941-eff4le0g	10	6	discuss	discuss	VBP
cord-265941-eff4le0g	10	7	the	the	DT
cord-265941-eff4le0g	10	8	role	role	NN
cord-265941-eff4le0g	10	9	of	of	IN
cord-265941-eff4le0g	10	10	each	each	DT
cord-265941-eff4le0g	10	11	RIPK	RIPK	NNP
cord-265941-eff4le0g	10	12	in	in	IN
cord-265941-eff4le0g	10	13	host	host	NN
cord-265941-eff4le0g	10	14	responses	response	NNS
cord-265941-eff4le0g	10	15	to	to	IN
cord-265941-eff4le0g	10	16	bacterial	bacterial	JJ
cord-265941-eff4le0g	10	17	and	and	CC
cord-265941-eff4le0g	10	18	viral	viral	JJ
cord-265941-eff4le0g	10	19	pathogens	pathogen	NNS
cord-265941-eff4le0g	10	20	,	,	,
cord-265941-eff4le0g	10	21	with	with	IN
cord-265941-eff4le0g	10	22	a	a	DT
cord-265941-eff4le0g	10	23	focus	focus	NN
cord-265941-eff4le0g	10	24	on	on	IN
cord-265941-eff4le0g	10	25	studies	study	NNS
cord-265941-eff4le0g	10	26	that	that	WDT
cord-265941-eff4le0g	10	27	have	have	VBP
cord-265941-eff4le0g	10	28	used	use	VBN
cord-265941-eff4le0g	10	29	pathogen	pathogen	NN
cord-265941-eff4le0g	10	30	infection	infection	NN
cord-265941-eff4le0g	10	31	models	model	NNS
cord-265941-eff4le0g	10	32	rather	rather	RB
cord-265941-eff4le0g	10	33	than	than	IN
cord-265941-eff4le0g	10	34	artificial	artificial	JJ
cord-265941-eff4le0g	10	35	stimulation	stimulation	NN
cord-265941-eff4le0g	10	36	with	with	IN
cord-265941-eff4le0g	10	37	purified	purify	VBN
cord-265941-eff4le0g	10	38	pathogen	pathogen	NN
cord-265941-eff4le0g	10	39	associated	associate	VBD
cord-265941-eff4le0g	10	40	molecular	molecular	JJ
cord-265941-eff4le0g	10	41	patterns	pattern	NNS
cord-265941-eff4le0g	10	42	.	.	.
cord-265941-eff4le0g	11	1	We	-PRON-	PRP
cord-265941-eff4le0g	11	2	also	also	RB
cord-265941-eff4le0g	11	3	discuss	discuss	VBP
cord-265941-eff4le0g	11	4	the	the	DT
cord-265941-eff4le0g	11	5	intricate	intricate	JJ
cord-265941-eff4le0g	11	6	mechanisms	mechanism	NNS
cord-265941-eff4le0g	11	7	of	of	IN
cord-265941-eff4le0g	11	8	host	host	NN
cord-265941-eff4le0g	11	9	evasion	evasion	NN
cord-265941-eff4le0g	11	10	by	by	IN
cord-265941-eff4le0g	11	11	pathogens	pathogen	NNS
cord-265941-eff4le0g	11	12	that	that	WDT
cord-265941-eff4le0g	11	13	specifically	specifically	RB
cord-265941-eff4le0g	11	14	target	target	VBP
cord-265941-eff4le0g	11	15	RIPKs	ripk	NNS
cord-265941-eff4le0g	11	16	for	for	IN
cord-265941-eff4le0g	11	17	inactivation	inactivation	NN
cord-265941-eff4le0g	11	18	,	,	,
cord-265941-eff4le0g	11	19	and	and	CC
cord-265941-eff4le0g	11	20	finally	finally	RB
cord-265941-eff4le0g	11	21	,	,	,
cord-265941-eff4le0g	11	22	we	-PRON-	PRP
cord-265941-eff4le0g	11	23	will	will	MD
cord-265941-eff4le0g	11	24	touch	touch	VB
cord-265941-eff4le0g	11	25	on	on	IN
cord-265941-eff4le0g	11	26	the	the	DT
cord-265941-eff4le0g	11	27	controversial	controversial	JJ
cord-265941-eff4le0g	11	28	issue	issue	NN
cord-265941-eff4le0g	11	29	of	of	IN
cord-265941-eff4le0g	11	30	drug	drug	NN
cord-265941-eff4le0g	11	31	development	development	NN
cord-265941-eff4le0g	11	32	for	for	IN
cord-265941-eff4le0g	11	33	kinase	kinase	NN
cord-265941-eff4le0g	11	34	inhibitors	inhibitor	NNS
cord-265941-eff4le0g	11	35	to	to	TO
cord-265941-eff4le0g	11	36	treat	treat	VB
cord-265941-eff4le0g	11	37	chronic	chronic	JJ
cord-265941-eff4le0g	11	38	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	11	39	and	and	CC
cord-265941-eff4le0g	11	40	neurological	neurological	JJ
cord-265941-eff4le0g	11	41	disorders	disorder	NNS
cord-265941-eff4le0g	11	42	,	,	,
cord-265941-eff4le0g	11	43	and	and	CC
cord-265941-eff4le0g	11	44	the	the	DT
cord-265941-eff4le0g	11	45	implications	implication	NNS
cord-265941-eff4le0g	11	46	this	this	DT
cord-265941-eff4le0g	11	47	may	may	MD
cord-265941-eff4le0g	11	48	have	have	VB
cord-265941-eff4le0g	11	49	on	on	IN
cord-265941-eff4le0g	11	50	the	the	DT
cord-265941-eff4le0g	11	51	outcome	outcome	NN
cord-265941-eff4le0g	11	52	of	of	IN
cord-265941-eff4le0g	11	53	pathogen	pathogen	NN
cord-265941-eff4le0g	11	54	infections	infection	NNS
cord-265941-eff4le0g	11	55	.	.	.
cord-265941-eff4le0g	12	1	Pathogen	pathogen	NN
cord-265941-eff4le0g	12	2	infection	infection	NN
cord-265941-eff4le0g	12	3	initiates	initiate	VBZ
cord-265941-eff4le0g	12	4	multiple	multiple	JJ
cord-265941-eff4le0g	12	5	innate	innate	JJ
cord-265941-eff4le0g	12	6	immune	immune	JJ
cord-265941-eff4le0g	12	7	signaling	signal	VBG
cord-265941-eff4le0g	12	8	pathways	pathway	NNS
cord-265941-eff4le0g	12	9	via	via	IN
cord-265941-eff4le0g	12	10	the	the	DT
cord-265941-eff4le0g	12	11	stimulation	stimulation	NN
cord-265941-eff4le0g	12	12	of	of	IN
cord-265941-eff4le0g	12	13	pattern	pattern	NN
cord-265941-eff4le0g	12	14	recognition	recognition	NN
cord-265941-eff4le0g	12	15	receptors	receptor	NNS
cord-265941-eff4le0g	12	16	(	(	-LRB-
cord-265941-eff4le0g	12	17	PRRs	PRRs	NNP
cord-265941-eff4le0g	12	18	)	)	-RRB-
cord-265941-eff4le0g	12	19	with	with	IN
cord-265941-eff4le0g	12	20	pathogen	pathogen	NN
cord-265941-eff4le0g	12	21	-	-	HYPH
cord-265941-eff4le0g	12	22	associated	associate	VBN
cord-265941-eff4le0g	12	23	molecular	molecular	JJ
cord-265941-eff4le0g	12	24	patterns	pattern	NNS
cord-265941-eff4le0g	12	25	(	(	-LRB-
cord-265941-eff4le0g	12	26	PAMPs	pamp	NNS
cord-265941-eff4le0g	12	27	)	)	-RRB-
cord-265941-eff4le0g	12	28	.	.	.
cord-265941-eff4le0g	13	1	The	the	DT
cord-265941-eff4le0g	13	2	outcomes	outcome	NNS
cord-265941-eff4le0g	13	3	of	of	IN
cord-265941-eff4le0g	13	4	PAMP	PAMP	NNP
cord-265941-eff4le0g	13	5	-	-	HYPH
cord-265941-eff4le0g	13	6	PRR	PRR	NNP
cord-265941-eff4le0g	13	7	signaling	signaling	NN
cord-265941-eff4le0g	13	8	are	be	VBP
cord-265941-eff4le0g	13	9	diverse	diverse	JJ
cord-265941-eff4le0g	13	10	,	,	,
cord-265941-eff4le0g	13	11	and	and	CC
cord-265941-eff4le0g	13	12	often	often	RB
cord-265941-eff4le0g	13	13	dependent	dependent	JJ
cord-265941-eff4le0g	13	14	on	on	IN
cord-265941-eff4le0g	13	15	pathogenspecific	pathogenspecific	NN
cord-265941-eff4le0g	13	16	virulence	virulence	NN
cord-265941-eff4le0g	13	17	factors	factor	NNS
cord-265941-eff4le0g	13	18	as	as	RB
cord-265941-eff4le0g	13	19	well	well	RB
cord-265941-eff4le0g	13	20	as	as	IN
cord-265941-eff4le0g	13	21	host	host	NN
cord-265941-eff4le0g	13	22	factors	factor	NNS
cord-265941-eff4le0g	13	23	including	include	VBG
cord-265941-eff4le0g	13	24	,	,	,
cord-265941-eff4le0g	13	25	cell	cell	NN
cord-265941-eff4le0g	13	26	type	type	NN
cord-265941-eff4le0g	13	27	,	,	,
cord-265941-eff4le0g	13	28	species	specie	NNS
cord-265941-eff4le0g	13	29	,	,	,
cord-265941-eff4le0g	13	30	existing	exist	VBG
cord-265941-eff4le0g	13	31	gene	gene	NN
cord-265941-eff4le0g	13	32	polymorphisms	polymorphism	NNS
cord-265941-eff4le0g	13	33	or	or	CC
cord-265941-eff4le0g	13	34	pre	pre	JJ
cord-265941-eff4le0g	13	35	-	-	JJ
cord-265941-eff4le0g	13	36	existing	existing	JJ
cord-265941-eff4le0g	13	37	co	co	NNS
cord-265941-eff4le0g	13	38	-	-	NNS
cord-265941-eff4le0g	13	39	morbidities	morbidity	NNS
cord-265941-eff4le0g	13	40	.	.	.
cord-265941-eff4le0g	14	1	Nevertheless	nevertheless	RB
cord-265941-eff4le0g	14	2	,	,	,
cord-265941-eff4le0g	14	3	the	the	DT
cord-265941-eff4le0g	14	4	signal	signal	NN
cord-265941-eff4le0g	14	5	transduction	transduction	NN
cord-265941-eff4le0g	14	6	that	that	WDT
cord-265941-eff4le0g	14	7	follows	follow	VBZ
cord-265941-eff4le0g	14	8	pathogen	pathogen	NN
cord-265941-eff4le0g	14	9	recognition	recognition	NN
cord-265941-eff4le0g	14	10	elicits	elicit	VBZ
cord-265941-eff4le0g	14	11	numerous	numerous	JJ
cord-265941-eff4le0g	14	12	defence	defence	NN
cord-265941-eff4le0g	14	13	mechanisms	mechanism	NNS
cord-265941-eff4le0g	14	14	,	,	,
cord-265941-eff4le0g	14	15	including	include	VBG
cord-265941-eff4le0g	14	16	the	the	DT
cord-265941-eff4le0g	14	17	induction	induction	NN
cord-265941-eff4le0g	14	18	of	of	IN
cord-265941-eff4le0g	14	19	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	14	20	cytokine	cytokine	NN
cord-265941-eff4le0g	14	21	,	,	,
cord-265941-eff4le0g	14	22	chemokine	chemokine	NN
cord-265941-eff4le0g	14	23	and	and	CC
cord-265941-eff4le0g	14	24	interferon	interferon	NN
cord-265941-eff4le0g	14	25	production	production	NN
cord-265941-eff4le0g	14	26	,	,	,
cord-265941-eff4le0g	14	27	activation	activation	NN
cord-265941-eff4le0g	14	28	of	of	IN
cord-265941-eff4le0g	14	29	programmed	programmed	JJ
cord-265941-eff4le0g	14	30	cell	cell	NN
cord-265941-eff4le0g	14	31	death	death	NN
cord-265941-eff4le0g	14	32	pathways	pathway	NNS
cord-265941-eff4le0g	14	33	,	,	,
cord-265941-eff4le0g	14	34	and	and	CC
cord-265941-eff4le0g	14	35	inevitably	inevitably	RB
cord-265941-eff4le0g	14	36	an	an	DT
cord-265941-eff4le0g	14	37	adaptive	adaptive	JJ
cord-265941-eff4le0g	14	38	immune	immune	JJ
cord-265941-eff4le0g	14	39	response	response	NN
cord-265941-eff4le0g	14	40	,	,	,
cord-265941-eff4le0g	14	41	all	all	DT
cord-265941-eff4le0g	14	42	of	of	IN
cord-265941-eff4le0g	14	43	which	which	WDT
cord-265941-eff4le0g	14	44	contribute	contribute	VBP
cord-265941-eff4le0g	14	45	to	to	IN
cord-265941-eff4le0g	14	46	pathogen	pathogen	NN
cord-265941-eff4le0g	14	47	control	control	NN
cord-265941-eff4le0g	14	48	and	and	CC
cord-265941-eff4le0g	14	49	elimination	elimination	NN
cord-265941-eff4le0g	14	50	[	[	-LRB-
cord-265941-eff4le0g	14	51	1	1	CD
cord-265941-eff4le0g	14	52	]	]	-RRB-
cord-265941-eff4le0g	14	53	.	.	.
cord-265941-eff4le0g	15	1	There	there	EX
cord-265941-eff4le0g	15	2	are	be	VBP
cord-265941-eff4le0g	15	3	seven	seven	CD
cord-265941-eff4le0g	15	4	members	member	NNS
cord-265941-eff4le0g	15	5	of	of	IN
cord-265941-eff4le0g	15	6	the	the	DT
cord-265941-eff4le0g	15	7	Receptor	Receptor	NNP
cord-265941-eff4le0g	15	8	Interacting	interact	VBG
cord-265941-eff4le0g	15	9	Protein	Protein	NNP
cord-265941-eff4le0g	15	10	Kinase	Kinase	NNP
cord-265941-eff4le0g	15	11	(	(	-LRB-
cord-265941-eff4le0g	15	12	RIPK	RIPK	NNP
cord-265941-eff4le0g	15	13	)	)	-RRB-
cord-265941-eff4le0g	15	14	family	family	NN
cord-265941-eff4le0g	15	15	,	,	,
cord-265941-eff4le0g	15	16	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	15	17	-	-	HYPH
cord-265941-eff4le0g	15	18	7	7	CD
cord-265941-eff4le0g	15	19	,	,	,
cord-265941-eff4le0g	15	20	some	some	DT
cord-265941-eff4le0g	15	21	of	of	IN
cord-265941-eff4le0g	15	22	which	which	WDT
cord-265941-eff4le0g	15	23	have	have	VBP
cord-265941-eff4le0g	15	24	emerged	emerge	VBN
cord-265941-eff4le0g	15	25	as	as	IN
cord-265941-eff4le0g	15	26	critical	critical	JJ
cord-265941-eff4le0g	15	27	effectors	effector	NNS
cord-265941-eff4le0g	15	28	of	of	IN
cord-265941-eff4le0g	15	29	immunity	immunity	NN
cord-265941-eff4le0g	15	30	to	to	IN
cord-265941-eff4le0g	15	31	infection	infection	NN
cord-265941-eff4le0g	15	32	with	with	IN
cord-265941-eff4le0g	15	33	a	a	DT
cord-265941-eff4le0g	15	34	diverse	diverse	JJ
cord-265941-eff4le0g	15	35	array	array	NN
cord-265941-eff4le0g	15	36	of	of	IN
cord-265941-eff4le0g	15	37	bacterial	bacterial	JJ
cord-265941-eff4le0g	15	38	,	,	,
cord-265941-eff4le0g	15	39	viral	viral	JJ
cord-265941-eff4le0g	15	40	and	and	CC
cord-265941-eff4le0g	15	41	protozoal	protozoal	JJ
cord-265941-eff4le0g	15	42	pathogens	pathogen	NNS
cord-265941-eff4le0g	15	43	.	.	.
cord-265941-eff4le0g	16	1	Structurally	structurally	RB
cord-265941-eff4le0g	16	2	and	and	CC
cord-265941-eff4le0g	16	3	functionally	functionally	RB
cord-265941-eff4le0g	16	4	,	,	,
cord-265941-eff4le0g	16	5	all	all	DT
cord-265941-eff4le0g	16	6	members	member	NNS
cord-265941-eff4le0g	16	7	of	of	IN
cord-265941-eff4le0g	16	8	the	the	DT
cord-265941-eff4le0g	16	9	RIPK	RIPK	NNP
cord-265941-eff4le0g	16	10	family	family	NN
cord-265941-eff4le0g	16	11	share	share	VBP
cord-265941-eff4le0g	16	12	a	a	DT
cord-265941-eff4le0g	16	13	homologous	homologous	JJ
cord-265941-eff4le0g	16	14	serine	serine	NN
cord-265941-eff4le0g	16	15	-	-	HYPH
cord-265941-eff4le0g	16	16	threonine	threonine	NN
cord-265941-eff4le0g	16	17	kinase	kinase	NN
cord-265941-eff4le0g	16	18	domain	domain	NN
cord-265941-eff4le0g	16	19	(	(	-LRB-
cord-265941-eff4le0g	16	20	KD	KD	NNP
cord-265941-eff4le0g	16	21	)	)	-RRB-
cord-265941-eff4le0g	16	22	with	with	IN
cord-265941-eff4le0g	16	23	a	a	DT
cord-265941-eff4le0g	16	24	catalytic	catalytic	JJ
cord-265941-eff4le0g	16	25	site	site	NN
cord-265941-eff4le0g	16	26	[	[	-LRB-
cord-265941-eff4le0g	16	27	2	2	CD
cord-265941-eff4le0g	16	28	]	]	-RRB-
cord-265941-eff4le0g	16	29	,	,	,
cord-265941-eff4le0g	16	30	with	with	IN
cord-265941-eff4le0g	16	31	RIPK2	ripk2	DT
cord-265941-eff4le0g	16	32	boasting	boast	VBG
cord-265941-eff4le0g	16	33	additional	additional	JJ
cord-265941-eff4le0g	16	34	tyrosine	tyrosine	NN
cord-265941-eff4le0g	16	35	kinase	kinase	NN
cord-265941-eff4le0g	16	36	activity	activity	NN
cord-265941-eff4le0g	16	37	[	[	-LRB-
cord-265941-eff4le0g	16	38	3	3	CD
cord-265941-eff4le0g	16	39	]	]	-RRB-
cord-265941-eff4le0g	16	40	.	.	.
cord-265941-eff4le0g	17	1	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	17	2	has	have	VBZ
cord-265941-eff4le0g	17	3	a	a	DT
cord-265941-eff4le0g	17	4	C	c	NN
cord-265941-eff4le0g	17	5	-	-	HYPH
cord-265941-eff4le0g	17	6	terminal	terminal	NN
cord-265941-eff4le0g	17	7	death	death	NN
cord-265941-eff4le0g	17	8	domain	domain	NN
cord-265941-eff4le0g	17	9	(	(	-LRB-
cord-265941-eff4le0g	17	10	DD	DD	NNP
cord-265941-eff4le0g	17	11	)	)	-RRB-
cord-265941-eff4le0g	17	12	,	,	,
cord-265941-eff4le0g	17	13	and	and	CC
cord-265941-eff4le0g	17	14	an	an	DT
cord-265941-eff4le0g	17	15	intermediate	intermediate	JJ
cord-265941-eff4le0g	17	16	domain	domain	NN
cord-265941-eff4le0g	17	17	(	(	-LRB-
cord-265941-eff4le0g	17	18	ID	ID	NNP
cord-265941-eff4le0g	17	19	)	)	-RRB-
cord-265941-eff4le0g	17	20	which	which	WDT
cord-265941-eff4le0g	17	21	harbors	harbor	VBZ
cord-265941-eff4le0g	17	22	a	a	DT
cord-265941-eff4le0g	17	23	RIP	RIP	NNP
cord-265941-eff4le0g	17	24	homotypic	homotypic	JJ
cord-265941-eff4le0g	17	25	interaction	interaction	NN
cord-265941-eff4le0g	17	26	motif	motif	NN
cord-265941-eff4le0g	17	27	(	(	-LRB-
cord-265941-eff4le0g	17	28	RHIM	RHIM	NNP
cord-265941-eff4le0g	17	29	)	)	-RRB-
cord-265941-eff4le0g	17	30	.	.	.
cord-265941-eff4le0g	18	1	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	18	2	contains	contain	VBZ
cord-265941-eff4le0g	18	3	a	a	DT
cord-265941-eff4le0g	18	4	C	c	NN
cord-265941-eff4le0g	18	5	-	-	HYPH
cord-265941-eff4le0g	18	6	terminal	terminal	NN
cord-265941-eff4le0g	18	7	CARD	card	NN
cord-265941-eff4le0g	18	8	(	(	-LRB-
cord-265941-eff4le0g	18	9	caspase	caspase	NN
cord-265941-eff4le0g	18	10	activation	activation	NN
cord-265941-eff4le0g	18	11	and	and	CC
cord-265941-eff4le0g	18	12	recruitment	recruitment	NN
cord-265941-eff4le0g	18	13	domain	domain	NN
cord-265941-eff4le0g	18	14	)	)	-RRB-
cord-265941-eff4le0g	18	15	and	and	CC
cord-265941-eff4le0g	18	16	an	an	DT
cord-265941-eff4le0g	18	17	ID	ID	NNP
cord-265941-eff4le0g	18	18	.	.	.
cord-265941-eff4le0g	19	1	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	19	2	has	have	VBZ
cord-265941-eff4le0g	19	3	a	a	DT
cord-265941-eff4le0g	19	4	C	c	NN
cord-265941-eff4le0g	19	5	-	-	HYPH
cord-265941-eff4le0g	19	6	terminal	terminal	JJ
cord-265941-eff4le0g	19	7	RHIM	RHIM	NNP
cord-265941-eff4le0g	19	8	domain	domain	NN
cord-265941-eff4le0g	19	9	alongside	alongside	IN
cord-265941-eff4le0g	19	10	the	the	DT
cord-265941-eff4le0g	19	11	N	n	CD
cord-265941-eff4le0g	19	12	-	-	HYPH
cord-265941-eff4le0g	19	13	terminal	terminal	NN
cord-265941-eff4le0g	19	14	KD	KD	NNP
cord-265941-eff4le0g	19	15	.	.	.
cord-265941-eff4le0g	20	1	RIPK4	RIPK4	NNP
cord-265941-eff4le0g	20	2	and	and	CC
cord-265941-eff4le0g	21	1	RIPK5	RIPK5	NNP
cord-265941-eff4le0g	21	2	are	be	VBP
cord-265941-eff4le0g	21	3	characterized	characterize	VBN
cord-265941-eff4le0g	21	4	by	by	IN
cord-265941-eff4le0g	21	5	C	c	NN
cord-265941-eff4le0g	21	6	-	-	HYPH
cord-265941-eff4le0g	21	7	terminal	terminal	NN
cord-265941-eff4le0g	21	8	ankyrin	ankyrin	NN
cord-265941-eff4le0g	21	9	repeats	repeat	VBZ
cord-265941-eff4le0g	21	10	,	,	,
cord-265941-eff4le0g	21	11	and	and	CC
cord-265941-eff4le0g	21	12	RIPK6	ripk6	NN
cord-265941-eff4le0g	21	13	and	and	CC
cord-265941-eff4le0g	21	14	RIPK7	RIPK7	VBN
cord-265941-eff4le0g	22	1	each	each	DT
cord-265941-eff4le0g	22	2	harbor	harbor	VBP
cord-265941-eff4le0g	22	3	a	a	DT
cord-265941-eff4le0g	22	4	leucine	leucine	NN
cord-265941-eff4le0g	22	5	-	-	HYPH
cord-265941-eff4le0g	22	6	rich	rich	JJ
cord-265941-eff4le0g	22	7	repeat	repeat	NN
cord-265941-eff4le0g	22	8	(	(	-LRB-
cord-265941-eff4le0g	22	9	LRR	LRR	NNP
cord-265941-eff4le0g	22	10	)	)	-RRB-
cord-265941-eff4le0g	22	11	motif	motif	NN
cord-265941-eff4le0g	22	12	,	,	,
cord-265941-eff4le0g	22	13	ankyrin	ankyrin	NNP
cord-265941-eff4le0g	22	14	repeats	repeat	VBZ
cord-265941-eff4le0g	22	15	,	,	,
cord-265941-eff4le0g	22	16	a	a	DT
cord-265941-eff4le0g	22	17	Ras	Ras	NNP
cord-265941-eff4le0g	22	18	-	-	HYPH
cord-265941-eff4le0g	22	19	of	of	IN
cord-265941-eff4le0g	22	20	-	-	HYPH
cord-265941-eff4le0g	22	21	complex	complex	JJ
cord-265941-eff4le0g	22	22	(	(	-LRB-
cord-265941-eff4le0g	22	23	Roc	Roc	NNP
cord-265941-eff4le0g	22	24	)	)	-RRB-
cord-265941-eff4le0g	22	25	domain	domain	NN
cord-265941-eff4le0g	22	26	followed	follow	VBN
cord-265941-eff4le0g	22	27	by	by	IN
cord-265941-eff4le0g	22	28	a	a	DT
cord-265941-eff4le0g	22	29	C	c	NN
cord-265941-eff4le0g	22	30	-	-	HYPH
cord-265941-eff4le0g	22	31	terminal	terminal	NN
cord-265941-eff4le0g	22	32	of	of	IN
cord-265941-eff4le0g	22	33	Roc	Roc	NNP
cord-265941-eff4le0g	22	34	(	(	-LRB-
cord-265941-eff4le0g	22	35	COR	COR	NNP
cord-265941-eff4le0g	22	36	)	)	-RRB-
cord-265941-eff4le0g	22	37	domain	domain	NN
cord-265941-eff4le0g	22	38	,	,	,
cord-265941-eff4le0g	22	39	and	and	CC
cord-265941-eff4le0g	22	40	a	a	DT
cord-265941-eff4le0g	22	41	WD40	WD40	NNP
cord-265941-eff4le0g	22	42	domain	domain	NN
cord-265941-eff4le0g	22	43	.	.	.
cord-265941-eff4le0g	23	1	To	to	IN
cord-265941-eff4le0g	23	2	date	date	NN
cord-265941-eff4le0g	23	3	,	,	,
cord-265941-eff4le0g	23	4	the	the	DT
cord-265941-eff4le0g	23	5	most	most	RBS
cord-265941-eff4le0g	23	6	studied	study	VBN
cord-265941-eff4le0g	23	7	RIPKs	ripks	NN
cord-265941-eff4le0g	23	8	in	in	IN
cord-265941-eff4le0g	23	9	relation	relation	NN
cord-265941-eff4le0g	23	10	to	to	IN
cord-265941-eff4le0g	23	11	inflammation	inflammation	NN
cord-265941-eff4le0g	23	12	of	of	IN
cord-265941-eff4le0g	23	13	host	host	NN
cord-265941-eff4le0g	23	14	immune	immune	JJ
cord-265941-eff4le0g	23	15	responses	response	NNS
cord-265941-eff4le0g	23	16	are	be	VBP
cord-265941-eff4le0g	23	17	RIPK1	ripk1	JJ
cord-265941-eff4le0g	23	18	,	,	,
cord-265941-eff4le0g	23	19	2	2	CD
cord-265941-eff4le0g	23	20	and	and	CC
cord-265941-eff4le0g	23	21	3	3	CD
cord-265941-eff4le0g	23	22	,	,	,
cord-265941-eff4le0g	23	23	with	with	IN
cord-265941-eff4le0g	23	24	RIPK7	RIPK7	VBN
cord-265941-eff4le0g	23	25	following	follow	VBG
cord-265941-eff4le0g	23	26	steadily	steadily	RB
cord-265941-eff4le0g	23	27	behind	behind	RB
cord-265941-eff4le0g	23	28	.	.	.
cord-265941-eff4le0g	24	1	This	this	DT
cord-265941-eff4le0g	24	2	rapidly	rapidly	RB
cord-265941-eff4le0g	24	3	moving	move	VBG
cord-265941-eff4le0g	24	4	field	field	NN
cord-265941-eff4le0g	24	5	has	have	VBZ
cord-265941-eff4le0g	24	6	brought	bring	VBN
cord-265941-eff4le0g	24	7	the	the	DT
cord-265941-eff4le0g	24	8	biochemical	biochemical	JJ
cord-265941-eff4le0g	24	9	functions	function	NNS
cord-265941-eff4le0g	24	10	of	of	IN
cord-265941-eff4le0g	24	11	RIPKs	ripks	PRP
cord-265941-eff4le0g	24	12	to	to	IN
cord-265941-eff4le0g	24	13	the	the	DT
cord-265941-eff4le0g	24	14	forefront	forefront	NN
cord-265941-eff4le0g	24	15	of	of	IN
cord-265941-eff4le0g	24	16	cellular	cellular	JJ
cord-265941-eff4le0g	24	17	immunity	immunity	NN
cord-265941-eff4le0g	24	18	.	.	.
cord-265941-eff4le0g	25	1	Here	here	RB
cord-265941-eff4le0g	25	2	,	,	,
cord-265941-eff4le0g	25	3	model	model	NN
cord-265941-eff4le0g	25	4	pathogens	pathogen	NNS
cord-265941-eff4le0g	25	5	including	include	VBG
cord-265941-eff4le0g	25	6	Listeria	Listeria	NNP
cord-265941-eff4le0g	25	7	monocytogenes	monocytogenes	NNP
cord-265941-eff4le0g	25	8	,	,	,
cord-265941-eff4le0g	25	9	Shigella	Shigella	NNP
cord-265941-eff4le0g	25	10	flexneri	flexneri	NN
cord-265941-eff4le0g	25	11	,	,	,
cord-265941-eff4le0g	25	12	Mycobacterium	Mycobacterium	NNP
cord-265941-eff4le0g	25	13	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	25	14	,	,	,
cord-265941-eff4le0g	25	15	influenza	influenza	NN
cord-265941-eff4le0g	25	16	A	a	DT
cord-265941-eff4le0g	25	17	virus	virus	NN
cord-265941-eff4le0g	25	18	(	(	-LRB-
cord-265941-eff4le0g	25	19	IAV	IAV	NNP
cord-265941-eff4le0g	25	20	)	)	-RRB-
cord-265941-eff4le0g	25	21	and	and	CC
cord-265941-eff4le0g	25	22	cytomegaloviruses	cytomegalovirus	NNS
cord-265941-eff4le0g	25	23	(	(	-LRB-
cord-265941-eff4le0g	25	24	CMV	CMV	NNP
cord-265941-eff4le0g	25	25	)	)	-RRB-
cord-265941-eff4le0g	25	26	have	have	VBP
cord-265941-eff4le0g	25	27	been	be	VBN
cord-265941-eff4le0g	25	28	instrumental	instrumental	JJ
cord-265941-eff4le0g	25	29	in	in	IN
cord-265941-eff4le0g	25	30	dissecting	dissect	VBG
cord-265941-eff4le0g	25	31	the	the	DT
cord-265941-eff4le0g	25	32	role	role	NN
cord-265941-eff4le0g	25	33	of	of	IN
cord-265941-eff4le0g	25	34	RIPKs	ripks	NN
cord-265941-eff4le0g	25	35	in	in	IN
cord-265941-eff4le0g	25	36	host	host	NN
cord-265941-eff4le0g	25	37	immunity	immunity	NN
cord-265941-eff4le0g	25	38	.	.	.
cord-265941-eff4le0g	26	1	Furthermore	furthermore	RB
cord-265941-eff4le0g	26	2	,	,	,
cord-265941-eff4le0g	26	3	research	research	NN
cord-265941-eff4le0g	26	4	over	over	IN
cord-265941-eff4le0g	26	5	the	the	DT
cord-265941-eff4le0g	26	6	past	past	JJ
cord-265941-eff4le0g	26	7	decade	decade	NN
cord-265941-eff4le0g	26	8	has	have	VBZ
cord-265941-eff4le0g	26	9	revealed	reveal	VBN
cord-265941-eff4le0g	26	10	multiple	multiple	JJ
cord-265941-eff4le0g	26	11	pathogenic	pathogenic	JJ
cord-265941-eff4le0g	26	12	mechanisms	mechanism	NNS
cord-265941-eff4le0g	26	13	of	of	IN
cord-265941-eff4le0g	26	14	bacteria	bacteria	NNS
cord-265941-eff4le0g	26	15	and	and	CC
cord-265941-eff4le0g	26	16	viruses	virus	NNS
cord-265941-eff4le0g	26	17	that	that	WDT
cord-265941-eff4le0g	26	18	specifically	specifically	RB
cord-265941-eff4le0g	26	19	target	target	VBP
cord-265941-eff4le0g	26	20	RIPKs	ripk	NNS
cord-265941-eff4le0g	26	21	or	or	CC
cord-265941-eff4le0g	26	22	their	-PRON-	PRP$
cord-265941-eff4le0g	26	23	downstream	downstream	JJ
cord-265941-eff4le0g	26	24	signaling	signal	VBG
cord-265941-eff4le0g	26	25	networks	network	NNS
cord-265941-eff4le0g	26	26	for	for	IN
cord-265941-eff4le0g	26	27	inactivation	inactivation	NN
cord-265941-eff4le0g	26	28	.	.	.
cord-265941-eff4le0g	27	1	Despite	despite	IN
cord-265941-eff4le0g	27	2	the	the	DT
cord-265941-eff4le0g	27	3	volume	volume	NN
cord-265941-eff4le0g	27	4	of	of	IN
cord-265941-eff4le0g	27	5	research	research	NN
cord-265941-eff4le0g	27	6	on	on	IN
cord-265941-eff4le0g	27	7	RIPKs	ripks	NN
cord-265941-eff4le0g	27	8	and	and	CC
cord-265941-eff4le0g	27	9	host	host	NN
cord-265941-eff4le0g	27	10	responses	response	NNS
cord-265941-eff4le0g	27	11	to	to	IN
cord-265941-eff4le0g	27	12	infection	infection	NN
cord-265941-eff4le0g	27	13	,	,	,
cord-265941-eff4le0g	27	14	there	there	EX
cord-265941-eff4le0g	27	15	is	be	VBZ
cord-265941-eff4le0g	27	16	a	a	DT
cord-265941-eff4le0g	27	17	long	long	JJ
cord-265941-eff4le0g	27	18	way	way	NN
cord-265941-eff4le0g	27	19	to	to	TO
cord-265941-eff4le0g	27	20	go	go	VB
cord-265941-eff4le0g	27	21	in	in	IN
cord-265941-eff4le0g	27	22	understanding	understand	VBG
cord-265941-eff4le0g	27	23	the	the	DT
cord-265941-eff4le0g	27	24	physiological	physiological	JJ
cord-265941-eff4le0g	27	25	role	role	NN
cord-265941-eff4le0g	27	26	of	of	IN
cord-265941-eff4le0g	27	27	each	each	DT
cord-265941-eff4le0g	27	28	RIPK	RIPK	NNS
cord-265941-eff4le0g	27	29	and	and	CC
cord-265941-eff4le0g	27	30	their	-PRON-	PRP$
cord-265941-eff4le0g	27	31	functional	functional	JJ
cord-265941-eff4le0g	27	32	domains	domain	NNS
cord-265941-eff4le0g	27	33	in	in	IN
cord-265941-eff4le0g	27	34	specific	specific	JJ
cord-265941-eff4le0g	27	35	infection	infection	NN
cord-265941-eff4le0g	27	36	settings	setting	NNS
cord-265941-eff4le0g	27	37	.	.	.
cord-265941-eff4le0g	28	1	This	this	DT
cord-265941-eff4le0g	28	2	is	be	VBZ
cord-265941-eff4le0g	28	3	partly	partly	RB
cord-265941-eff4le0g	28	4	due	due	JJ
cord-265941-eff4le0g	28	5	the	the	DT
cord-265941-eff4le0g	28	6	fact	fact	NN
cord-265941-eff4le0g	28	7	that	that	IN
cord-265941-eff4le0g	28	8	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	28	9	and	and	CC
cord-265941-eff4le0g	28	10	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	28	11	are	be	VBP
cord-265941-eff4le0g	28	12	implicated	implicate	VBN
cord-265941-eff4le0g	28	13	in	in	IN
cord-265941-eff4le0g	28	14	pro	pro	JJ
cord-265941-eff4le0g	28	15	-	-	JJ
cord-265941-eff4le0g	28	16	survival	survival	JJ
cord-265941-eff4le0g	28	17	transcriptional	transcriptional	JJ
cord-265941-eff4le0g	28	18	pathways	pathway	NNS
cord-265941-eff4le0g	28	19	as	as	RB
cord-265941-eff4le0g	28	20	well	well	RB
cord-265941-eff4le0g	28	21	as	as	IN
cord-265941-eff4le0g	28	22	cell	cell	NN
cord-265941-eff4le0g	28	23	death	death	NN
cord-265941-eff4le0g	28	24	,	,	,
cord-265941-eff4le0g	28	25	but	but	CC
cord-265941-eff4le0g	28	26	also	also	RB
cord-265941-eff4le0g	28	27	due	due	IN
cord-265941-eff4le0g	28	28	to	to	IN
cord-265941-eff4le0g	28	29	the	the	DT
cord-265941-eff4le0g	28	30	ongoing	ongoing	JJ
cord-265941-eff4le0g	28	31	discovery	discovery	NN
cord-265941-eff4le0g	28	32	of	of	IN
cord-265941-eff4le0g	28	33	novel	novel	JJ
cord-265941-eff4le0g	28	34	virulence	virulence	NN
cord-265941-eff4le0g	28	35	mechanisms	mechanism	NNS
cord-265941-eff4le0g	28	36	of	of	IN
cord-265941-eff4le0g	28	37	pathogens	pathogen	NNS
cord-265941-eff4le0g	28	38	.	.	.
cord-265941-eff4le0g	29	1	In	in	IN
cord-265941-eff4le0g	29	2	this	this	DT
cord-265941-eff4le0g	29	3	review	review	NN
cord-265941-eff4le0g	29	4	,	,	,
cord-265941-eff4le0g	29	5	we	-PRON-	PRP
cord-265941-eff4le0g	29	6	will	will	MD
cord-265941-eff4le0g	29	7	provide	provide	VB
cord-265941-eff4le0g	29	8	an	an	DT
cord-265941-eff4le0g	29	9	up	up	NN
cord-265941-eff4le0g	29	10	to	to	IN
cord-265941-eff4le0g	29	11	date	date	NN
cord-265941-eff4le0g	29	12	account	account	NN
cord-265941-eff4le0g	29	13	of	of	IN
cord-265941-eff4le0g	29	14	RIPKmediated	ripkmediated	JJ
cord-265941-eff4le0g	29	15	host	host	NN
cord-265941-eff4le0g	29	16	responses	response	NNS
cord-265941-eff4le0g	29	17	to	to	IN
cord-265941-eff4le0g	29	18	bacterial	bacterial	JJ
cord-265941-eff4le0g	29	19	and	and	CC
cord-265941-eff4le0g	29	20	viral	viral	JJ
cord-265941-eff4le0g	29	21	infections	infection	NNS
cord-265941-eff4le0g	29	22	as	as	RB
cord-265941-eff4le0g	29	23	well	well	RB
cord-265941-eff4le0g	29	24	as	as	IN
cord-265941-eff4le0g	29	25	the	the	DT
cord-265941-eff4le0g	29	26	mechanisms	mechanism	NNS
cord-265941-eff4le0g	29	27	pathogens	pathogen	NNS
cord-265941-eff4le0g	29	28	have	have	VBP
cord-265941-eff4le0g	29	29	evolved	evolve	VBN
cord-265941-eff4le0g	29	30	to	to	TO
cord-265941-eff4le0g	29	31	evade	evade	VB
cord-265941-eff4le0g	29	32	RIPK	ripk	JJ
cord-265941-eff4le0g	29	33	signaling	signaling	NN
cord-265941-eff4le0g	29	34	outcomes	outcome	NNS
cord-265941-eff4le0g	29	35	.	.	.
cord-265941-eff4le0g	30	1	Importantly	importantly	RB
cord-265941-eff4le0g	30	2	,	,	,
cord-265941-eff4le0g	30	3	we	-PRON-	PRP
cord-265941-eff4le0g	30	4	have	have	VBP
cord-265941-eff4le0g	30	5	focused	focus	VBN
cord-265941-eff4le0g	30	6	on	on	IN
cord-265941-eff4le0g	30	7	studies	study	NNS
cord-265941-eff4le0g	30	8	that	that	WDT
cord-265941-eff4le0g	30	9	have	have	VBP
cord-265941-eff4le0g	30	10	utilised	utilise	VBN
cord-265941-eff4le0g	30	11	in	in	IN
cord-265941-eff4le0g	30	12	vitro	vitro	FW
cord-265941-eff4le0g	30	13	or	or	CC
cord-265941-eff4le0g	30	14	in	in	IN
cord-265941-eff4le0g	30	15	vivo	vivo	NN
cord-265941-eff4le0g	30	16	infections	infection	NNS
cord-265941-eff4le0g	30	17	with	with	IN
cord-265941-eff4le0g	30	18	pathogenic	pathogenic	JJ
cord-265941-eff4le0g	30	19	organisms	organism	NNS
cord-265941-eff4le0g	30	20	to	to	TO
cord-265941-eff4le0g	30	21	stimulate	stimulate	VB
cord-265941-eff4le0g	30	22	physiological	physiological	JJ
cord-265941-eff4le0g	30	23	immune	immune	JJ
cord-265941-eff4le0g	30	24	responses	response	NNS
cord-265941-eff4le0g	30	25	,	,	,
cord-265941-eff4le0g	30	26	rather	rather	RB
cord-265941-eff4le0g	30	27	than	than	IN
cord-265941-eff4le0g	30	28	those	those	DT
cord-265941-eff4le0g	30	29	that	that	WDT
cord-265941-eff4le0g	30	30	have	have	VBP
cord-265941-eff4le0g	30	31	used	use	VBN
cord-265941-eff4le0g	30	32	purified	purify	VBN
cord-265941-eff4le0g	30	33	or	or	CC
cord-265941-eff4le0g	30	34	synthetic	synthetic	JJ
cord-265941-eff4le0g	30	35	stimulants	stimulant	NNS
cord-265941-eff4le0g	30	36	,	,	,
cord-265941-eff4le0g	30	37	for	for	IN
cord-265941-eff4le0g	30	38	example	example	NN
cord-265941-eff4le0g	30	39	lipopolysaccharide	lipopolysaccharide	NN
cord-265941-eff4le0g	30	40	(	(	-LRB-
cord-265941-eff4le0g	30	41	LPS	LPS	NNP
cord-265941-eff4le0g	30	42	)	)	-RRB-
cord-265941-eff4le0g	30	43	or	or	CC
cord-265941-eff4le0g	30	44	polyinosinic	polyinosinic	NNP
cord-265941-eff4le0g	30	45	:	:	:
cord-265941-eff4le0g	30	46	polycytidylic	polycytidylic	JJ
cord-265941-eff4le0g	30	47	acid	acid	NNP
cord-265941-eff4le0g	30	48	(	(	-LRB-
cord-265941-eff4le0g	30	49	Poly	Poly	NNP
cord-265941-eff4le0g	30	50	I	i	NN
cord-265941-eff4le0g	30	51	:	:	:
cord-265941-eff4le0g	30	52	C	C	NNP
cord-265941-eff4le0g	30	53	)	)	-RRB-
cord-265941-eff4le0g	30	54	.	.	.
cord-265941-eff4le0g	31	1	We	-PRON-	PRP
cord-265941-eff4le0g	31	2	note	note	VBP
cord-265941-eff4le0g	31	3	that	that	IN
cord-265941-eff4le0g	31	4	although	although	IN
cord-265941-eff4le0g	31	5	we	-PRON-	PRP
cord-265941-eff4le0g	31	6	were	be	VBD
cord-265941-eff4le0g	31	7	not	not	RB
cord-265941-eff4le0g	31	8	able	able	JJ
cord-265941-eff4le0g	31	9	to	to	TO
cord-265941-eff4le0g	31	10	discuss	discuss	VB
cord-265941-eff4le0g	31	11	all	all	DT
cord-265941-eff4le0g	31	12	relevant	relevant	JJ
cord-265941-eff4le0g	31	13	pathogens	pathogen	NNS
cord-265941-eff4le0g	31	14	,	,	,
cord-265941-eff4le0g	31	15	including	include	VBG
cord-265941-eff4le0g	31	16	protozoal	protozoal	NNP
cord-265941-eff4le0g	31	17	organisms	organism	NNS
cord-265941-eff4le0g	31	18	,	,	,
cord-265941-eff4le0g	31	19	we	-PRON-	PRP
cord-265941-eff4le0g	31	20	have	have	VBP
cord-265941-eff4le0g	31	21	generated	generate	VBN
cord-265941-eff4le0g	31	22	a	a	DT
cord-265941-eff4le0g	31	23	comprehensive	comprehensive	JJ
cord-265941-eff4le0g	31	24	list	list	NN
cord-265941-eff4le0g	31	25	of	of	IN
cord-265941-eff4le0g	31	26	pathogens	pathogen	NNS
cord-265941-eff4le0g	31	27	,	,	,
cord-265941-eff4le0g	31	28	the	the	DT
cord-265941-eff4le0g	31	29	associated	associate	VBN
cord-265941-eff4le0g	31	30	RIPK	RIPK	NNP
cord-265941-eff4le0g	31	31	signaling	signal	VBG
cord-265941-eff4le0g	31	32	pathways	pathway	NNS
cord-265941-eff4le0g	31	33	and	and	CC
cord-265941-eff4le0g	31	34	relevant	relevant	JJ
cord-265941-eff4le0g	31	35	references	reference	NNS
cord-265941-eff4le0g	31	36	in	in	IN
cord-265941-eff4le0g	31	37	Table	Table	NNP
cord-265941-eff4le0g	31	38	1	1	CD
cord-265941-eff4le0g	31	39	.	.	.
cord-265941-eff4le0g	32	1	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	32	2	regulates	regulate	VBZ
cord-265941-eff4le0g	32	3	inflammation	inflammation	NN
cord-265941-eff4le0g	32	4	in	in	IN
cord-265941-eff4le0g	32	5	response	response	NN
cord-265941-eff4le0g	32	6	to	to	IN
cord-265941-eff4le0g	32	7	death	death	NN
cord-265941-eff4le0g	32	8	receptors	receptor	NNS
cord-265941-eff4le0g	32	9	(	(	-LRB-
cord-265941-eff4le0g	32	10	DR	DR	NNP
cord-265941-eff4le0g	32	11	)	)	-RRB-
cord-265941-eff4le0g	32	12	,	,	,
cord-265941-eff4le0g	32	13	including	include	VBG
cord-265941-eff4le0g	32	14	tumour	tumour	NN
cord-265941-eff4le0g	32	15	necrosis	necrosis	NN
cord-265941-eff4le0g	32	16	factor	factor	NN
cord-265941-eff4le0g	32	17	receptor	receptor	NN
cord-265941-eff4le0g	32	18	1	1	CD
cord-265941-eff4le0g	32	19	(	(	-LRB-
cord-265941-eff4le0g	32	20	TNFR1	TNFR1	NNP
cord-265941-eff4le0g	32	21	)	)	-RRB-
cord-265941-eff4le0g	32	22	,	,	,
cord-265941-eff4le0g	32	23	TNF	tnf	NN
cord-265941-eff4le0g	32	24	-	-	HYPH
cord-265941-eff4le0g	32	25	related	relate	VBN
cord-265941-eff4le0g	32	26	apoptosis	apoptosis	NN
cord-265941-eff4le0g	32	27	-	-	HYPH
cord-265941-eff4le0g	32	28	inducing	induce	VBG
cord-265941-eff4le0g	32	29	ligand	ligand	NN
cord-265941-eff4le0g	32	30	receptors	receptor	NNS
cord-265941-eff4le0g	32	31	1	1	CD
cord-265941-eff4le0g	32	32	and	and	CC
cord-265941-eff4le0g	32	33	2	2	CD
cord-265941-eff4le0g	32	34	(	(	-LRB-
cord-265941-eff4le0g	32	35	TRAILR1/2	trailr1/2	NN
cord-265941-eff4le0g	32	36	)	)	-RRB-
cord-265941-eff4le0g	32	37	and	and	CC
cord-265941-eff4le0g	32	38	Fas	Fas	NNP
cord-265941-eff4le0g	32	39	[	[	-LRB-
cord-265941-eff4le0g	32	40	4	4	CD
cord-265941-eff4le0g	32	41	]	]	-RRB-
cord-265941-eff4le0g	32	42	[	[	-LRB-
cord-265941-eff4le0g	32	43	5	5	CD
cord-265941-eff4le0g	32	44	]	]	-RRB-
cord-265941-eff4le0g	32	45	[	[	-LRB-
cord-265941-eff4le0g	32	46	6	6	CD
cord-265941-eff4le0g	32	47	]	]	-RRB-
cord-265941-eff4le0g	32	48	,	,	,
cord-265941-eff4le0g	32	49	as	as	RB
cord-265941-eff4le0g	32	50	well	well	RB
cord-265941-eff4le0g	32	51	as	as	IN
cord-265941-eff4le0g	32	52	toll	toll	NN
cord-265941-eff4le0g	32	53	-	-	HYPH
cord-265941-eff4le0g	32	54	like	like	JJ
cord-265941-eff4le0g	32	55	receptor	receptor	NN
cord-265941-eff4le0g	32	56	(	(	-LRB-
cord-265941-eff4le0g	32	57	TLR)3	TLR)3	NNP
cord-265941-eff4le0g	32	58	and	and	CC
cord-265941-eff4le0g	32	59	TLR4	TLR4	NNP
cord-265941-eff4le0g	32	60	[	[	-LRB-
cord-265941-eff4le0g	32	61	7	7	CD
cord-265941-eff4le0g	32	62	,	,	,
cord-265941-eff4le0g	32	63	8	8	CD
cord-265941-eff4le0g	32	64	]	]	-RRB-
cord-265941-eff4le0g	32	65	(	(	-LRB-
cord-265941-eff4le0g	32	66	Fig	Fig	NNP
cord-265941-eff4le0g	32	67	.	.	.
cord-265941-eff4le0g	32	68	1	1	CD
cord-265941-eff4le0g	32	69	)	)	-RRB-
cord-265941-eff4le0g	32	70	.	.	.
cord-265941-eff4le0g	33	1	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	33	2	,	,	,
cord-265941-eff4le0g	33	3	although	although	IN
cord-265941-eff4le0g	33	4	best	well	RBS
cord-265941-eff4le0g	33	5	known	know	VBN
cord-265941-eff4le0g	33	6	for	for	IN
cord-265941-eff4le0g	33	7	its	-PRON-	PRP$
cord-265941-eff4le0g	33	8	role	role	NN
cord-265941-eff4le0g	33	9	in	in	IN
cord-265941-eff4le0g	33	10	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	33	11	(	(	-LRB-
cord-265941-eff4le0g	33	12	discussed	discuss	VBN
cord-265941-eff4le0g	33	13	later	later	RB
cord-265941-eff4le0g	33	14	)	)	-RRB-
cord-265941-eff4le0g	33	15	,	,	,
cord-265941-eff4le0g	33	16	can	can	MD
cord-265941-eff4le0g	33	17	act	act	VB
cord-265941-eff4le0g	33	18	in	in	IN
cord-265941-eff4le0g	33	19	concert	concert	NN
cord-265941-eff4le0g	33	20	with	with	IN
cord-265941-eff4le0g	33	21	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	33	22	to	to	TO
cord-265941-eff4le0g	33	23	engage	engage	VB
cord-265941-eff4le0g	33	24	in	in	IN
cord-265941-eff4le0g	33	25	pro	pro	JJ
cord-265941-eff4le0g	33	26	-	-	JJ
cord-265941-eff4le0g	33	27	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	33	28	,	,	,
cord-265941-eff4le0g	33	29	non	non	JJ
cord-265941-eff4le0g	33	30	-	-	JJ
cord-265941-eff4le0g	33	31	cell	cell	JJ
cord-265941-eff4le0g	33	32	death	death	NN
cord-265941-eff4le0g	33	33	signaling	signal	VBG
cord-265941-eff4le0g	33	34	[	[	-LRB-
cord-265941-eff4le0g	33	35	9	9	CD
cord-265941-eff4le0g	33	36	]	]	-RRB-
cord-265941-eff4le0g	33	37	.	.	.
cord-265941-eff4le0g	34	1	Here	here	RB
cord-265941-eff4le0g	34	2	we	-PRON-	PRP
cord-265941-eff4le0g	34	3	will	will	MD
cord-265941-eff4le0g	34	4	focus	focus	VB
cord-265941-eff4le0g	34	5	on	on	IN
cord-265941-eff4le0g	34	6	research	research	NN
cord-265941-eff4le0g	34	7	that	that	WDT
cord-265941-eff4le0g	34	8	indicate	indicate	VBP
cord-265941-eff4le0g	34	9	direct	direct	JJ
cord-265941-eff4le0g	34	10	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	34	11	and/or	and/or	CC
cord-265941-eff4le0g	34	12	RIPK3	ripk3	NN
cord-265941-eff4le0g	34	13	involvement	involvement	NN
cord-265941-eff4le0g	34	14	in	in	IN
cord-265941-eff4le0g	34	15	pathways	pathway	NNS
cord-265941-eff4le0g	34	16	specifically	specifically	RB
cord-265941-eff4le0g	34	17	described	describe	VBN
cord-265941-eff4le0g	34	18	to	to	TO
cord-265941-eff4le0g	34	19	be	be	VB
cord-265941-eff4le0g	34	20	cell	cell	NN
cord-265941-eff4le0g	34	21	death	death	NN
cord-265941-eff4le0g	34	22	-	-	HYPH
cord-265941-eff4le0g	34	23	independent	independent	JJ
cord-265941-eff4le0g	34	24	during	during	IN
cord-265941-eff4le0g	34	25	host	host	NN
cord-265941-eff4le0g	34	26	infection	infection	NN
cord-265941-eff4le0g	34	27	.	.	.
cord-265941-eff4le0g	35	1	West	West	NNP
cord-265941-eff4le0g	35	2	Nile	Nile	NNP
cord-265941-eff4le0g	35	3	virus	virus	NN
cord-265941-eff4le0g	35	4	(	(	-LRB-
cord-265941-eff4le0g	35	5	WNV	WNV	NNP
cord-265941-eff4le0g	35	6	)	)	-RRB-
cord-265941-eff4le0g	35	7	and	and	CC
cord-265941-eff4le0g	35	8	Zika	Zika	NNP
cord-265941-eff4le0g	35	9	virus	virus	NN
cord-265941-eff4le0g	35	10	(	(	-LRB-
cord-265941-eff4le0g	35	11	ZIKV	ZIKV	NNP
cord-265941-eff4le0g	35	12	)	)	-RRB-
cord-265941-eff4le0g	35	13	are	be	VBP
cord-265941-eff4le0g	35	14	medically	medically	RB
cord-265941-eff4le0g	35	15	important	important	JJ
cord-265941-eff4le0g	35	16	arboviruses	arbovirus	NNS
cord-265941-eff4le0g	35	17	that	that	WDT
cord-265941-eff4le0g	35	18	cause	cause	VBP
cord-265941-eff4le0g	35	19	severe	severe	JJ
cord-265941-eff4le0g	35	20	neurological	neurological	JJ
cord-265941-eff4le0g	35	21	disease	disease	NN
cord-265941-eff4le0g	35	22	in	in	IN
cord-265941-eff4le0g	35	23	humans	human	NNS
cord-265941-eff4le0g	35	24	[	[	-LRB-
cord-265941-eff4le0g	35	25	23	23	CD
cord-265941-eff4le0g	35	26	,	,	,
cord-265941-eff4le0g	35	27	24	24	CD
cord-265941-eff4le0g	35	28	]	]	-RRB-
cord-265941-eff4le0g	35	29	.	.	.
cord-265941-eff4le0g	36	1	Control	Control	NNP
cord-265941-eff4le0g	36	2	of	of	IN
cord-265941-eff4le0g	36	3	WNV	WNV	NNP
cord-265941-eff4le0g	36	4	requires	require	VBZ
cord-265941-eff4le0g	36	5	robust	robust	JJ
cord-265941-eff4le0g	36	6	neuroinflammation	neuroinflammation	NN
cord-265941-eff4le0g	36	7	and	and	CC
cord-265941-eff4le0g	36	8	infiltration	infiltration	NN
cord-265941-eff4le0g	36	9	of	of	IN
cord-265941-eff4le0g	36	10	peripheral	peripheral	JJ
cord-265941-eff4le0g	36	11	leukocytes	leukocyte	NNS
cord-265941-eff4le0g	36	12	into	into	IN
cord-265941-eff4le0g	36	13	the	the	DT
cord-265941-eff4le0g	36	14	central	central	JJ
cord-265941-eff4le0g	36	15	nervous	nervous	JJ
cord-265941-eff4le0g	36	16	system	system	NN
cord-265941-eff4le0g	36	17	(	(	-LRB-
cord-265941-eff4le0g	36	18	CNS	CNS	NNP
cord-265941-eff4le0g	36	19	)	)	-RRB-
cord-265941-eff4le0g	36	20	,	,	,
cord-265941-eff4le0g	36	21	mediated	mediate	VBN
cord-265941-eff4le0g	36	22	by	by	IN
cord-265941-eff4le0g	36	23	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	36	24	and	and	CC
cord-265941-eff4le0g	36	25	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	36	26	[	[	-LRB-
cord-265941-eff4le0g	36	27	23	23	CD
cord-265941-eff4le0g	36	28	,	,	,
cord-265941-eff4le0g	36	29	25	25	CD
cord-265941-eff4le0g	36	30	]	]	-RRB-
cord-265941-eff4le0g	36	31	.	.	.
cord-265941-eff4le0g	37	1	Daniels	Daniels	NNP
cord-265941-eff4le0g	37	2	et	et	NNP
cord-265941-eff4le0g	37	3	al	al	NNP
cord-265941-eff4le0g	37	4	.	.	.
cord-265941-eff4le0g	38	1	[	[	-LRB-
cord-265941-eff4le0g	38	2	25	25	CD
cord-265941-eff4le0g	38	3	]	]	-RRB-
cord-265941-eff4le0g	38	4	demonstrated	demonstrate	VBD
cord-265941-eff4le0g	38	5	that	that	IN
cord-265941-eff4le0g	38	6	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	38	7	−	−	NNP
cord-265941-eff4le0g	39	1	/−	/−	.
cord-265941-eff4le0g	40	1	and	and	CC
cord-265941-eff4le0g	40	2	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	41	1	kinase	kinase	NN
cord-265941-eff4le0g	41	2	-	-	HYPH
cord-265941-eff4le0g	41	3	dead	dead	JJ
cord-265941-eff4le0g	41	4	(	(	-LRB-
cord-265941-eff4le0g	41	5	Ripk1	ripk1	JJ
cord-265941-eff4le0g	41	6	K45A	K45A	NNP
cord-265941-eff4le0g	41	7	/	/	SYM
cord-265941-eff4le0g	41	8	K45A	K45A	NNP
cord-265941-eff4le0g	41	9	)	)	-RRB-
cord-265941-eff4le0g	42	1	mice	mouse	NNS
cord-265941-eff4le0g	42	2	have	have	VBP
cord-265941-eff4le0g	42	3	suppressed	suppress	VBN
cord-265941-eff4le0g	42	4	TLR	TLR	NNP
cord-265941-eff4le0g	42	5	-	-	HYPH
cord-265941-eff4le0g	42	6	induced	induce	VBN
cord-265941-eff4le0g	42	7	chemokine	chemokine	NN
cord-265941-eff4le0g	42	8	expression	expression	NN
cord-265941-eff4le0g	42	9	,	,	,
cord-265941-eff4le0g	42	10	as	as	RB
cord-265941-eff4le0g	42	11	well	well	RB
cord-265941-eff4le0g	42	12	as	as	IN
cord-265941-eff4le0g	42	13	reduced	reduce	VBN
cord-265941-eff4le0g	42	14	recruitment	recruitment	NN
cord-265941-eff4le0g	42	15	of	of	IN
cord-265941-eff4le0g	42	16	T	T	NNP
cord-265941-eff4le0g	42	17	lymphocytes	lymphocyte	NNS
cord-265941-eff4le0g	42	18	and	and	CC
cord-265941-eff4le0g	42	19	myeloid	myeloid	NN
cord-265941-eff4le0g	42	20	cells	cell	NNS
cord-265941-eff4le0g	42	21	into	into	IN
cord-265941-eff4le0g	42	22	the	the	DT
cord-265941-eff4le0g	42	23	CNS	CNS	NNP
cord-265941-eff4le0g	42	24	,	,	,
cord-265941-eff4le0g	42	25	resulting	result	VBG
cord-265941-eff4le0g	42	26	in	in	IN
cord-265941-eff4le0g	42	27	accelerated	accelerated	JJ
cord-265941-eff4le0g	42	28	virus	virus	NN
cord-265941-eff4le0g	42	29	-	-	HYPH
cord-265941-eff4le0g	42	30	induced	induce	VBN
cord-265941-eff4le0g	42	31	mortality	mortality	NN
cord-265941-eff4le0g	42	32	.	.	.
cord-265941-eff4le0g	43	1	Similarly	similarly	RB
cord-265941-eff4le0g	43	2	,	,	,
cord-265941-eff4le0g	43	3	direct	direct	JJ
cord-265941-eff4le0g	43	4	ZIKV	zikv	NN
cord-265941-eff4le0g	43	5	infection	infection	NN
cord-265941-eff4le0g	43	6	in	in	IN
cord-265941-eff4le0g	43	7	the	the	DT
cord-265941-eff4le0g	43	8	CNS	CNS	NNP
cord-265941-eff4le0g	43	9	of	of	IN
cord-265941-eff4le0g	43	10	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	43	11	−	−	NNP
cord-265941-eff4le0g	44	1	/−	/−	.
cord-265941-eff4le0g	44	2	,	,	,
cord-265941-eff4le0g	45	1	Ripk1	Ripk1	NNP
cord-265941-eff4le0g	45	2	K45A	K45A	NNP
cord-265941-eff4le0g	45	3	/	/	SYM
cord-265941-eff4le0g	45	4	K45A	K45A	NNP
cord-265941-eff4le0g	45	5	and	and	CC
cord-265941-eff4le0g	45	6	Dai	Dai	NNP
cord-265941-eff4le0g	45	7	−	−	NNP
cord-265941-eff4le0g	46	1	/−	/−	.
cord-265941-eff4le0g	47	1	mice	mouse	NNS
cord-265941-eff4le0g	47	2	induces	induce	VBZ
cord-265941-eff4le0g	47	3	rapid	rapid	JJ
cord-265941-eff4le0g	47	4	mortality	mortality	NN
cord-265941-eff4le0g	47	5	and	and	CC
cord-265941-eff4le0g	47	6	elevated	elevate	VBN
cord-265941-eff4le0g	47	7	viral	viral	JJ
cord-265941-eff4le0g	47	8	titres	titre	NNS
cord-265941-eff4le0g	47	9	within	within	IN
cord-265941-eff4le0g	47	10	the	the	DT
cord-265941-eff4le0g	47	11	brain	brain	NN
cord-265941-eff4le0g	47	12	[	[	-LRB-
cord-265941-eff4le0g	47	13	26	26	CD
cord-265941-eff4le0g	47	14	]	]	-RRB-
cord-265941-eff4le0g	47	15	.	.	.
cord-265941-eff4le0g	48	1	Pharmacological	pharmacological	JJ
cord-265941-eff4le0g	48	2	blockade	blockade	NN
cord-265941-eff4le0g	48	3	of	of	IN
cord-265941-eff4le0g	48	4	RIPK3	ripk3	NN
cord-265941-eff4le0g	48	5	also	also	RB
cord-265941-eff4le0g	48	6	enhances	enhance	VBZ
cord-265941-eff4le0g	48	7	ZIKV	ZIKV	NNP
cord-265941-eff4le0g	48	8	replication	replication	NN
cord-265941-eff4le0g	48	9	in	in	IN
cord-265941-eff4le0g	48	10	human	human	JJ
cord-265941-eff4le0g	48	11	neuroblastomas	neuroblastomas	NN
cord-265941-eff4le0g	48	12	.	.	.
cord-265941-eff4le0g	49	1	This	this	DT
cord-265941-eff4le0g	49	2	intrinsic	intrinsic	JJ
cord-265941-eff4le0g	49	3	neuronal	neuronal	JJ
cord-265941-eff4le0g	49	4	cell	cell	NN
cord-265941-eff4le0g	49	5	defect	defect	NN
cord-265941-eff4le0g	49	6	results	result	NNS
cord-265941-eff4le0g	49	7	from	from	IN
cord-265941-eff4le0g	49	8	disrupted	disrupt	VBN
cord-265941-eff4le0g	49	9	DAI	DAI	NNP
cord-265941-eff4le0g	49	10	/	/	SYM
cord-265941-eff4le0g	49	11	RIPK	ripk	NN
cord-265941-eff4le0g	49	12	-	-	HYPH
cord-265941-eff4le0g	49	13	mediated	mediate	VBN
cord-265941-eff4le0g	49	14	transcription	transcription	NN
cord-265941-eff4le0g	49	15	of	of	IN
cord-265941-eff4le0g	49	16	immunoresponsive	immunoresponsive	JJ
cord-265941-eff4le0g	49	17	gene	gene	NN
cord-265941-eff4le0g	49	18	1	1	CD
cord-265941-eff4le0g	49	19	(	(	-LRB-
cord-265941-eff4le0g	49	20	IRG1	IRG1	NNP
cord-265941-eff4le0g	49	21	)	)	-RRB-
cord-265941-eff4le0g	49	22	required	require	VBN
cord-265941-eff4le0g	49	23	for	for	IN
cord-265941-eff4le0g	49	24	itaconate	itaconate	NN
cord-265941-eff4le0g	49	25	production	production	NN
cord-265941-eff4le0g	49	26	.	.	.
cord-265941-eff4le0g	50	1	Itaconate	Itaconate	NNP
cord-265941-eff4le0g	50	2	inhibits	inhibit	VBZ
cord-265941-eff4le0g	50	3	succinate	succinate	NN
cord-265941-eff4le0g	50	4	dehydrogenase	dehydrogenase	NN
cord-265941-eff4le0g	50	5	(	(	-LRB-
cord-265941-eff4le0g	50	6	SDH	SDH	NNP
cord-265941-eff4le0g	50	7	)	)	-RRB-
cord-265941-eff4le0g	50	8	activity	activity	NN
cord-265941-eff4le0g	50	9	and	and	CC
cord-265941-eff4le0g	50	10	subsequently	subsequently	RB
cord-265941-eff4le0g	50	11	reprograms	reprogram	VBZ
cord-265941-eff4le0g	50	12	neuronal	neuronal	JJ
cord-265941-eff4le0g	50	13	metabolism	metabolism	NN
cord-265941-eff4le0g	50	14	into	into	IN
cord-265941-eff4le0g	50	15	an	an	DT
cord-265941-eff4le0g	50	16	antiviral	antiviral	JJ
cord-265941-eff4le0g	50	17	state	state	NN
cord-265941-eff4le0g	50	18	[	[	-LRB-
cord-265941-eff4le0g	50	19	26	26	CD
cord-265941-eff4le0g	50	20	]	]	-RRB-
cord-265941-eff4le0g	51	1	[	[	-LRB-
cord-265941-eff4le0g	51	2	27	27	CD
cord-265941-eff4le0g	51	3	]	]	-RRB-
cord-265941-eff4le0g	51	4	[	[	-LRB-
cord-265941-eff4le0g	51	5	28	28	CD
cord-265941-eff4le0g	51	6	]	]	-RRB-
cord-265941-eff4le0g	51	7	.	.	.
cord-265941-eff4le0g	52	1	As	as	IN
cord-265941-eff4le0g	52	2	such	such	JJ
cord-265941-eff4le0g	52	3	,	,	,
cord-265941-eff4le0g	52	4	these	these	DT
cord-265941-eff4le0g	52	5	results	result	NNS
cord-265941-eff4le0g	52	6	highlight	highlight	VBP
cord-265941-eff4le0g	52	7	the	the	DT
cord-265941-eff4le0g	52	8	contribution	contribution	NN
cord-265941-eff4le0g	52	9	of	of	IN
cord-265941-eff4le0g	52	10	RIPK1/3	RIPK1/3	NNP
cord-265941-eff4le0g	52	11	in	in	IN
cord-265941-eff4le0g	52	12	defence	defence	NN
cord-265941-eff4le0g	52	13	against	against	IN
cord-265941-eff4le0g	52	14	neurovirulent	neurovirulent	NNP
cord-265941-eff4le0g	52	15	viruses	virus	NNS
cord-265941-eff4le0g	52	16	,	,	,
cord-265941-eff4le0g	52	17	independently	independently	RB
cord-265941-eff4le0g	52	18	of	of	IN
cord-265941-eff4le0g	52	19	cell	cell	NN
cord-265941-eff4le0g	52	20	death	death	NN
cord-265941-eff4le0g	52	21	.	.	.
cord-265941-eff4le0g	53	1	CMVs	CMVs	NNPS
cord-265941-eff4le0g	53	2	are	be	VBP
cord-265941-eff4le0g	53	3	large	large	JJ
cord-265941-eff4le0g	53	4	double	double	RB
cord-265941-eff4le0g	53	5	-	-	HYPH
cord-265941-eff4le0g	53	6	stranded	strand	VBN
cord-265941-eff4le0g	53	7	DNA	dna	NN
cord-265941-eff4le0g	53	8	viruses	virus	NNS
cord-265941-eff4le0g	53	9	that	that	WDT
cord-265941-eff4le0g	53	10	have	have	VBP
cord-265941-eff4le0g	53	11	the	the	DT
cord-265941-eff4le0g	53	12	capacity	capacity	NN
cord-265941-eff4le0g	53	13	to	to	TO
cord-265941-eff4le0g	53	14	encode	encode	VB
cord-265941-eff4le0g	53	15	viral	viral	JJ
cord-265941-eff4le0g	53	16	effectors	effector	NNS
cord-265941-eff4le0g	53	17	that	that	WDT
cord-265941-eff4le0g	53	18	directly	directly	RB
cord-265941-eff4le0g	53	19	manipulate	manipulate	VBP
cord-265941-eff4le0g	53	20	components	component	NNS
cord-265941-eff4le0g	53	21	of	of	IN
cord-265941-eff4le0g	53	22	host	host	NN
cord-265941-eff4le0g	53	23	immune	immune	JJ
cord-265941-eff4le0g	53	24	pathways	pathway	NNS
cord-265941-eff4le0g	53	25	.	.	.
cord-265941-eff4le0g	54	1	Murine	murine	JJ
cord-265941-eff4le0g	54	2	CMV	CMV	NNP
cord-265941-eff4le0g	54	3	(	(	-LRB-
cord-265941-eff4le0g	54	4	MCMV	MCMV	NNP
cord-265941-eff4le0g	54	5	)	)	-RRB-
cord-265941-eff4le0g	54	6	expresses	express	VBZ
cord-265941-eff4le0g	54	7	the	the	DT
cord-265941-eff4le0g	54	8	M45	M45	NNP
cord-265941-eff4le0g	54	9	protein	protein	NN
cord-265941-eff4le0g	54	10	,	,	,
cord-265941-eff4le0g	54	11	which	which	WDT
cord-265941-eff4le0g	54	12	interacts	interact	VBZ
cord-265941-eff4le0g	54	13	with	with	IN
cord-265941-eff4le0g	54	14	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	54	15	through	through	IN
cord-265941-eff4le0g	54	16	its	-PRON-	PRP$
cord-265941-eff4le0g	54	17	catalytically	catalytically	RB
cord-265941-eff4le0g	54	18	inactive	inactive	JJ
cord-265941-eff4le0g	54	19	ribonucleotide	ribonucleotide	NN
cord-265941-eff4le0g	54	20	reductase	reductase	NN
cord-265941-eff4le0g	54	21	(	(	-LRB-
cord-265941-eff4le0g	54	22	RR	rr	NN
cord-265941-eff4le0g	54	23	)	)	-RRB-
cord-265941-eff4le0g	54	24	domain	domain	NN
cord-265941-eff4le0g	54	25	and	and	CC
cord-265941-eff4le0g	54	26	inhibits	inhibit	VBZ
cord-265941-eff4le0g	54	27	RIPK1	ripk1	JJ
cord-265941-eff4le0g	54	28	ubiquitylation	ubiquitylation	NNP
cord-265941-eff4le0g	54	29	[	[	-LRB-
cord-265941-eff4le0g	54	30	29	29	CD
cord-265941-eff4le0g	54	31	]	]	-RRB-
cord-265941-eff4le0g	54	32	.	.	.
cord-265941-eff4le0g	55	1	This	this	DT
cord-265941-eff4le0g	55	2	process	process	NN
cord-265941-eff4le0g	55	3	blocks	block	VBZ
cord-265941-eff4le0g	55	4	pathways	pathway	NNS
cord-265941-eff4le0g	55	5	dependent	dependent	JJ
cord-265941-eff4le0g	55	6	on	on	IN
cord-265941-eff4le0g	55	7	polyubiquitylated	polyubiquitylated	NNP
cord-265941-eff4le0g	55	8	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	55	9	,	,	,
cord-265941-eff4le0g	55	10	including	include	VBG
cord-265941-eff4le0g	55	11	TNF	tnf	NN
cord-265941-eff4le0g	55	12	-	-	HYPH
cord-265941-eff4le0g	55	13	induced	induce	VBN
cord-265941-eff4le0g	55	14	NF	nf	NN
cord-265941-eff4le0g	55	15	-	-	HYPH
cord-265941-eff4le0g	55	16	ĸB	ĸB	NNP
cord-265941-eff4le0g	55	17	and	and	CC
cord-265941-eff4le0g	55	18	p38	p38	CD
cord-265941-eff4le0g	55	19	MAPK	MAPK	NNP
cord-265941-eff4le0g	55	20	activation	activation	NN
cord-265941-eff4le0g	55	21	,	,	,
cord-265941-eff4le0g	55	22	as	as	RB
cord-265941-eff4le0g	55	23	well	well	RB
cord-265941-eff4le0g	55	24	as	as	IN
cord-265941-eff4le0g	55	25	TLR3-induced	TLR3-induced	NNP
cord-265941-eff4le0g	55	26	NF	NF	NNP
cord-265941-eff4le0g	55	27	-	-	HYPH
cord-265941-eff4le0g	55	28	ĸB	ĸB	NNP
cord-265941-eff4le0g	55	29	activation	activation	NN
cord-265941-eff4le0g	55	30	,	,	,
cord-265941-eff4le0g	55	31	thus	thus	RB
cord-265941-eff4le0g	55	32	facilitating	facilitate	VBG
cord-265941-eff4le0g	55	33	immune	immune	JJ
cord-265941-eff4le0g	55	34	evasion	evasion	NN
cord-265941-eff4le0g	55	35	.	.	.
cord-265941-eff4le0g	56	1	M45	M45	NNP
cord-265941-eff4le0g	56	2	is	be	VBZ
cord-265941-eff4le0g	56	3	also	also	RB
cord-265941-eff4le0g	56	4	shown	show	VBN
cord-265941-eff4le0g	56	5	to	to	TO
cord-265941-eff4le0g	56	6	bind	bind	VB
cord-265941-eff4le0g	56	7	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	56	8	,	,	,
cord-265941-eff4le0g	56	9	RIPK3	ripk3	NN
cord-265941-eff4le0g	56	10	and	and	CC
cord-265941-eff4le0g	56	11	DAI	DAI	NNP
cord-265941-eff4le0g	56	12	via	via	IN
cord-265941-eff4le0g	56	13	its	-PRON-	PRP$
cord-265941-eff4le0g	56	14	N	n	CD
cord-265941-eff4le0g	56	15	-	-	HYPH
cord-265941-eff4le0g	56	16	terminal	terminal	JJ
cord-265941-eff4le0g	56	17	RHIM	RHIM	NNP
cord-265941-eff4le0g	56	18	domain	domain	NN
cord-265941-eff4le0g	56	19	,	,	,
cord-265941-eff4le0g	56	20	which	which	WDT
cord-265941-eff4le0g	56	21	interferes	interfere	VBZ
cord-265941-eff4le0g	56	22	with	with	IN
cord-265941-eff4le0g	56	23	DAI	DAI	NNP
cord-265941-eff4le0g	56	24	-	-	HYPH
cord-265941-eff4le0g	56	25	induced	induce	VBN
cord-265941-eff4le0g	56	26	NF	nf	NN
cord-265941-eff4le0g	56	27	-	-	HYPH
cord-265941-eff4le0g	56	28	ĸB	ĸB	NNP
cord-265941-eff4le0g	56	29	signaling	signal	VBG
cord-265941-eff4le0g	56	30	[	[	-LRB-
cord-265941-eff4le0g	56	31	22	22	CD
cord-265941-eff4le0g	56	32	]	]	-RRB-
cord-265941-eff4le0g	56	33	.	.	.
cord-265941-eff4le0g	57	1	Similarly	similarly	RB
cord-265941-eff4le0g	57	2	,	,	,
cord-265941-eff4le0g	57	3	human	human	JJ
cord-265941-eff4le0g	57	4	CMV	CMV	NNP
cord-265941-eff4le0g	57	5	(	(	-LRB-
cord-265941-eff4le0g	57	6	HCMV	HCMV	NNP
cord-265941-eff4le0g	57	7	)	)	-RRB-
cord-265941-eff4le0g	57	8	is	be	VBZ
cord-265941-eff4le0g	57	9	able	able	JJ
cord-265941-eff4le0g	57	10	to	to	TO
cord-265941-eff4le0g	57	11	inhibit	inhibit	VB
cord-265941-eff4le0g	57	12	RIPK1-mediated	RIPK1-mediated	NNP
cord-265941-eff4le0g	57	13	NF	NF	NNP
cord-265941-eff4le0g	57	14	-	-	HYPH
cord-265941-eff4le0g	57	15	ĸB	ĸB	NNP
cord-265941-eff4le0g	58	1	signaling	signal	VBG
cord-265941-eff4le0g	58	2	through	through	IN
cord-265941-eff4le0g	58	3	synergistic	synergistic	JJ
cord-265941-eff4le0g	58	4	function	function	NN
cord-265941-eff4le0g	58	5	of	of	IN
cord-265941-eff4le0g	58	6	its	-PRON-	PRP$
cord-265941-eff4le0g	58	7	encoded	encode	VBN
cord-265941-eff4le0g	58	8	UL48	UL48	NNP
cord-265941-eff4le0g	58	9	and	and	CC
cord-265941-eff4le0g	58	10	UL45	UL45	NNP
cord-265941-eff4le0g	58	11	proteins	protein	NNS
cord-265941-eff4le0g	58	12	[	[	-LRB-
cord-265941-eff4le0g	58	13	30	30	CD
cord-265941-eff4le0g	58	14	]	]	-RRB-
cord-265941-eff4le0g	58	15	.	.	.
cord-265941-eff4le0g	59	1	During	during	IN
cord-265941-eff4le0g	59	2	the	the	DT
cord-265941-eff4le0g	59	3	late	late	JJ
cord-265941-eff4le0g	59	4	stages	stage	NNS
cord-265941-eff4le0g	59	5	of	of	IN
cord-265941-eff4le0g	59	6	infection	infection	NN
cord-265941-eff4le0g	59	7	,	,	,
cord-265941-eff4le0g	59	8	UL48	UL48	NNP
cord-265941-eff4le0g	59	9	cleaves	cleave	VBZ
cord-265941-eff4le0g	59	10	the	the	DT
cord-265941-eff4le0g	59	11	K63-polyubiquitin	K63-polyubiquitin	NNP
cord-265941-eff4le0g	59	12	chains	chain	NNS
cord-265941-eff4le0g	59	13	on	on	IN
cord-265941-eff4le0g	59	14	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	59	15	,	,	,
cord-265941-eff4le0g	59	16	thus	thus	RB
cord-265941-eff4le0g	59	17	preventing	prevent	VBG
cord-265941-eff4le0g	59	18	TNF	TNF	NNP
cord-265941-eff4le0g	59	19	-	-	HYPH
cord-265941-eff4le0g	59	20	induced	induce	VBN
cord-265941-eff4le0g	59	21	NF	nf	NN
cord-265941-eff4le0g	59	22	-	-	HYPH
cord-265941-eff4le0g	59	23	ĸB	ĸb	NN
cord-265941-eff4le0g	59	24	activation	activation	NN
cord-265941-eff4le0g	59	25	[	[	-LRB-
cord-265941-eff4le0g	59	26	30	30	CD
cord-265941-eff4le0g	59	27	,	,	,
cord-265941-eff4le0g	59	28	31	31	CD
cord-265941-eff4le0g	59	29	]	]	-RRB-
cord-265941-eff4le0g	59	30	.	.	.
cord-265941-eff4le0g	60	1	UL45	UL45	NNP
cord-265941-eff4le0g	60	2	supports	support	VBZ
cord-265941-eff4le0g	60	3	this	this	DT
cord-265941-eff4le0g	60	4	process	process	NN
cord-265941-eff4le0g	60	5	by	by	IN
cord-265941-eff4le0g	60	6	enhancing	enhance	VBG
cord-265941-eff4le0g	60	7	UL48-RIPK1	ul48-ripk1	JJ
cord-265941-eff4le0g	60	8	interaction	interaction	NN
cord-265941-eff4le0g	60	9	and	and	CC
cord-265941-eff4le0g	60	10	re	re	NN
cord-265941-eff4le0g	60	11	-	-	NN
cord-265941-eff4le0g	60	12	localization	localization	NN
cord-265941-eff4le0g	60	13	of	of	IN
cord-265941-eff4le0g	60	14	RIPK1	ripk1	XX
cord-265941-eff4le0g	60	15	to	to	IN
cord-265941-eff4le0g	60	16	the	the	DT
cord-265941-eff4le0g	60	17	cytoplasmic	cytoplasmic	JJ
cord-265941-eff4le0g	60	18	virion	virion	NN
cord-265941-eff4le0g	60	19	assembly	assembly	NN
cord-265941-eff4le0g	60	20	complex	complex	NN
cord-265941-eff4le0g	60	21	.	.	.
cord-265941-eff4le0g	61	1	Conversely	conversely	RB
cord-265941-eff4le0g	61	2	,	,	,
cord-265941-eff4le0g	61	3	RIP	rip	NN
cord-265941-eff4le0g	61	4	kinases	kinase	NNS
cord-265941-eff4le0g	61	5	can	can	MD
cord-265941-eff4le0g	61	6	also	also	RB
cord-265941-eff4le0g	61	7	be	be	VB
cord-265941-eff4le0g	61	8	utilised	utilise	VBN
cord-265941-eff4le0g	61	9	to	to	TO
cord-265941-eff4le0g	61	10	promote	promote	VB
cord-265941-eff4le0g	61	11	viral	viral	JJ
cord-265941-eff4le0g	61	12	propagation	propagation	NN
cord-265941-eff4le0g	61	13	.	.	.
cord-265941-eff4le0g	62	1	Following	follow	VBG
cord-265941-eff4le0g	62	2	Japanese	japanese	JJ
cord-265941-eff4le0g	62	3	encephalitis	encephalitis	RB
cord-265941-eff4le0g	62	4	virus	virus	NN
cord-265941-eff4le0g	62	5	(	(	-LRB-
cord-265941-eff4le0g	62	6	JEV	JEV	NNP
cord-265941-eff4le0g	62	7	)	)	-RRB-
cord-265941-eff4le0g	62	8	infection	infection	NN
cord-265941-eff4le0g	62	9	,	,	,
cord-265941-eff4le0g	62	10	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	62	11	gene	gene	NN
cord-265941-eff4le0g	62	12	expression	expression	NN
cord-265941-eff4le0g	62	13	is	be	VBZ
cord-265941-eff4le0g	62	14	upregulated	upregulate	VBN
cord-265941-eff4le0g	62	15	in	in	IN
cord-265941-eff4le0g	62	16	primary	primary	JJ
cord-265941-eff4le0g	62	17	neurons	neuron	NNS
cord-265941-eff4le0g	62	18	of	of	IN
cord-265941-eff4le0g	62	19	wild	wild	JJ
cord-265941-eff4le0g	62	20	-	-	HYPH
cord-265941-eff4le0g	62	21	type	type	NN
cord-265941-eff4le0g	62	22	(	(	-LRB-
cord-265941-eff4le0g	62	23	WT	WT	NNP
cord-265941-eff4le0g	62	24	)	)	-RRB-
cord-265941-eff4le0g	62	25	mice	mouse	NNS
cord-265941-eff4le0g	62	26	,	,	,
cord-265941-eff4le0g	62	27	which	which	WDT
cord-265941-eff4le0g	62	28	corresponds	correspond	VBZ
cord-265941-eff4le0g	62	29	to	to	IN
cord-265941-eff4le0g	62	30	heightened	heighten	VBN
cord-265941-eff4le0g	62	31	viral	viral	JJ
cord-265941-eff4le0g	62	32	titres	titre	NNS
cord-265941-eff4le0g	62	33	[	[	-LRB-
cord-265941-eff4le0g	62	34	32	32	CD
cord-265941-eff4le0g	62	35	]	]	-RRB-
cord-265941-eff4le0g	62	36	.	.	.
cord-265941-eff4le0g	63	1	RNA	rna	NN
cord-265941-eff4le0g	63	2	-	-	HYPH
cord-265941-eff4le0g	63	3	sequencing	sequencing	NN
cord-265941-eff4le0g	63	4	of	of	IN
cord-265941-eff4le0g	63	5	infected	infected	JJ
cord-265941-eff4le0g	63	6	brain	brain	NN
cord-265941-eff4le0g	63	7	tissues	tissue	NNS
cord-265941-eff4le0g	63	8	revealed	reveal	VBD
cord-265941-eff4le0g	63	9	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	63	10	−	−	NNP
cord-265941-eff4le0g	64	1	/−	/−	.
cord-265941-eff4le0g	65	1	mice	mouse	NNS
cord-265941-eff4le0g	65	2	upregulate	upregulate	VBP
cord-265941-eff4le0g	65	3	a	a	DT
cord-265941-eff4le0g	65	4	number	number	NN
cord-265941-eff4le0g	65	5	of	of	IN
cord-265941-eff4le0g	65	6	IFN	IFN	NNP
cord-265941-eff4le0g	65	7	-	-	HYPH
cord-265941-eff4le0g	65	8	stimulated	stimulate	VBN
cord-265941-eff4le0g	65	9	genes	gene	NNS
cord-265941-eff4le0g	65	10	(	(	-LRB-
cord-265941-eff4le0g	65	11	ISGs	ISGs	NNP
cord-265941-eff4le0g	65	12	)	)	-RRB-
cord-265941-eff4le0g	65	13	,	,	,
cord-265941-eff4le0g	65	14	independently	independently	RB
cord-265941-eff4le0g	65	15	of	of	IN
cord-265941-eff4le0g	65	16	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	65	17	and	and	CC
cord-265941-eff4le0g	65	18	MLKL	MLKL	NNP
cord-265941-eff4le0g	65	19	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	65	20	.	.	.
cord-265941-eff4le0g	66	1	Silencing	silence	VBG
cord-265941-eff4le0g	66	2	of	of	IN
cord-265941-eff4le0g	66	3	the	the	DT
cord-265941-eff4le0g	66	4	ISG	ISG	NNP
cord-265941-eff4le0g	66	5	,	,	,
cord-265941-eff4le0g	66	6	IFI44	IFI44	NNP
cord-265941-eff4le0g	66	7	L	L	NNP
cord-265941-eff4le0g	66	8	,	,	,
cord-265941-eff4le0g	66	9	in	in	IN
cord-265941-eff4le0g	66	10	both	both	CC
cord-265941-eff4le0g	66	11	WT	WT	NNP
cord-265941-eff4le0g	66	12	and	and	CC
cord-265941-eff4le0g	66	13	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	66	14	−	−	NNP
cord-265941-eff4le0g	66	15	/−	/−	.
cord-265941-eff4le0g	66	16	neurons	neuron	NNS
cord-265941-eff4le0g	66	17	increases	increase	VBZ
cord-265941-eff4le0g	66	18	viral	viral	JJ
cord-265941-eff4le0g	66	19	RNA	RNA	NNP
cord-265941-eff4le0g	66	20	levels	level	NNS
cord-265941-eff4le0g	66	21	,	,	,
cord-265941-eff4le0g	66	22	suggesting	suggest	VBG
cord-265941-eff4le0g	66	23	that	that	IN
cord-265941-eff4le0g	66	24	the	the	DT
cord-265941-eff4le0g	66	25	elevated	elevated	JJ
cord-265941-eff4le0g	66	26	RIPK3	ripk3	NN
cord-265941-eff4le0g	66	27	assists	assist	VBZ
cord-265941-eff4le0g	66	28	with	with	IN
cord-265941-eff4le0g	66	29	JEV	JEV	NNP
cord-265941-eff4le0g	66	30	immune	immune	JJ
cord-265941-eff4le0g	66	31	evasion	evasion	NN
cord-265941-eff4le0g	66	32	.	.	.
cord-265941-eff4le0g	67	1	[	[	-LRB-
cord-265941-eff4le0g	67	2	194	194	CD
cord-265941-eff4le0g	67	3	]	]	-RRB-
cord-265941-eff4le0g	67	4	Chlamydia	Chlamydia	NNP
cord-265941-eff4le0g	67	5	muridarum	muridarum	NN
cord-265941-eff4le0g	67	6	Gram	Gram	NNP
cord-265941-eff4le0g	67	7	-	-	HYPH
cord-265941-eff4le0g	67	8	negative	negative	JJ
cord-265941-eff4le0g	68	1	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	68	2	Activates	activate	VBZ
cord-265941-eff4le0g	68	3	-Mouse	-mouse	NN
cord-265941-eff4le0g	68	4	,	,	,
cord-265941-eff4le0g	68	5	human	human	JJ
cord-265941-eff4le0g	68	6	[	[	-LRB-
cord-265941-eff4le0g	68	7	194	194	CD
cord-265941-eff4le0g	68	8	,	,	,
cord-265941-eff4le0g	68	9	195	195	CD
cord-265941-eff4le0g	68	10	]	]	-RRB-
cord-265941-eff4le0g	68	11	Citrobacter	Citrobacter	NNP
cord-265941-eff4le0g	68	12	rodentium	rodentium	NN
cord-265941-eff4le0g	69	1	Gram	gram	NN
cord-265941-eff4le0g	69	2	-	-	HYPH
cord-265941-eff4le0g	69	3	negative	negative	JJ
cord-265941-eff4le0g	69	4	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	69	5	,	,	.
cord-265941-eff4le0g	70	1	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	71	1	Inhibits	inhibit	VBZ
cord-265941-eff4le0g	71	2	EspL	EspL	NNP
cord-265941-eff4le0g	71	3	Mouse	Mouse	NNP
cord-265941-eff4le0g	71	4	[	[	-LRB-
cord-265941-eff4le0g	71	5	113	113	CD
cord-265941-eff4le0g	71	6	]	]	-RRB-
cord-265941-eff4le0g	72	1	Enteropathogenic	Enteropathogenic	NNP
cord-265941-eff4le0g	72	2	RIPK3-regulated	RIPK3-regulated	NNP
cord-265941-eff4le0g	72	3	type	type	NN
cord-265941-eff4le0g	73	1	I	-PRON-	PRP
cord-265941-eff4le0g	73	2	IFN	IFN	NNP
cord-265941-eff4le0g	73	3	signaling	signal	VBG
cord-265941-eff4le0g	73	4	is	be	VBZ
cord-265941-eff4le0g	73	5	also	also	RB
cord-265941-eff4le0g	73	6	shown	show	VBN
cord-265941-eff4le0g	73	7	to	to	TO
cord-265941-eff4le0g	73	8	be	be	VB
cord-265941-eff4le0g	73	9	crucial	crucial	JJ
cord-265941-eff4le0g	73	10	in	in	IN
cord-265941-eff4le0g	73	11	anti	anti	JJ
cord-265941-eff4le0g	73	12	-	-	JJ
cord-265941-eff4le0g	73	13	IAV	IAV	NNP
cord-265941-eff4le0g	73	14	immunity	immunity	NN
cord-265941-eff4le0g	73	15	.	.	.
cord-265941-eff4le0g	74	1	Indeed	indeed	RB
cord-265941-eff4le0g	74	2	,	,	,
cord-265941-eff4le0g	74	3	infected	infected	JJ
cord-265941-eff4le0g	74	4	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	74	5	−	−	NNP
cord-265941-eff4le0g	75	1	/−	/−	.
cord-265941-eff4le0g	76	1	mice	mouse	NNS
cord-265941-eff4le0g	76	2	exhibit	exhibit	VBP
cord-265941-eff4le0g	76	3	increased	increase	VBN
cord-265941-eff4le0g	76	4	pulmonary	pulmonary	JJ
cord-265941-eff4le0g	76	5	viral	viral	JJ
cord-265941-eff4le0g	76	6	load	load	NN
cord-265941-eff4le0g	76	7	and	and	CC
cord-265941-eff4le0g	76	8	enhanced	enhance	VBN
cord-265941-eff4le0g	76	9	immunopathology	immunopathology	NN
cord-265941-eff4le0g	76	10	and	and	CC
cord-265941-eff4le0g	76	11	mortality	mortality	NN
cord-265941-eff4le0g	76	12	[	[	-LRB-
cord-265941-eff4le0g	76	13	33	33	CD
cord-265941-eff4le0g	76	14	]	]	-RRB-
cord-265941-eff4le0g	76	15	.	.	.
cord-265941-eff4le0g	77	1	This	this	DT
cord-265941-eff4le0g	77	2	susceptibility	susceptibility	NN
cord-265941-eff4le0g	77	3	is	be	VBZ
cord-265941-eff4le0g	77	4	largely	largely	RB
cord-265941-eff4le0g	77	5	attributed	attribute	VBN
cord-265941-eff4le0g	77	6	to	to	IN
cord-265941-eff4le0g	77	7	defective	defective	JJ
cord-265941-eff4le0g	77	8	IFN	IFN	NNP
cord-265941-eff4le0g	77	9	production	production	NN
cord-265941-eff4le0g	77	10	from	from	IN
cord-265941-eff4le0g	77	11	infected	infected	JJ
cord-265941-eff4le0g	77	12	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	77	13	-/macrophages	-/macrophage	NNS
cord-265941-eff4le0g	77	14	,	,	,
cord-265941-eff4le0g	77	15	independent	independent	JJ
cord-265941-eff4le0g	77	16	of	of	IN
cord-265941-eff4le0g	77	17	IAV	IAV	NNP
cord-265941-eff4le0g	77	18	-	-	HYPH
cord-265941-eff4le0g	77	19	associated	associate	VBN
cord-265941-eff4le0g	77	20	cell	cell	NN
cord-265941-eff4le0g	77	21	death	death	NN
cord-265941-eff4le0g	77	22	outcomes	outcome	NNS
cord-265941-eff4le0g	77	23	.	.	.
cord-265941-eff4le0g	78	1	Specifically	specifically	RB
cord-265941-eff4le0g	78	2	,	,	,
cord-265941-eff4le0g	78	3	RIPK3	ripk3	NN
cord-265941-eff4le0g	78	4	controls	control	NNS
cord-265941-eff4le0g	78	5	type	type	NN
cord-265941-eff4le0g	79	1	I	-PRON-	PRP
cord-265941-eff4le0g	79	2	IFN	IFN	NNP
cord-265941-eff4le0g	79	3	signaling	signal	VBG
cord-265941-eff4le0g	79	4	at	at	IN
cord-265941-eff4le0g	79	5	the	the	DT
cord-265941-eff4le0g	79	6	transcriptional	transcriptional	JJ
cord-265941-eff4le0g	79	7	level	level	NN
cord-265941-eff4le0g	79	8	,	,	,
cord-265941-eff4le0g	79	9	where	where	WRB
cord-265941-eff4le0g	79	10	virus	virus	NN
cord-265941-eff4le0g	79	11	-	-	HYPH
cord-265941-eff4le0g	79	12	induced	induce	VBN
cord-265941-eff4le0g	79	13	upregulation	upregulation	NN
cord-265941-eff4le0g	79	14	of	of	IN
cord-265941-eff4le0g	79	15	RIPK3	ripk3	NN
cord-265941-eff4le0g	79	16	disrupts	disrupt	VBZ
cord-265941-eff4le0g	79	17	RIPK1-MAVS	RIPK1-MAVS	NNP
cord-265941-eff4le0g	79	18	interaction	interaction	NN
cord-265941-eff4le0g	79	19	and	and	CC
cord-265941-eff4le0g	79	20	reduces	reduce	VBZ
cord-265941-eff4le0g	79	21	IFN	IFN	NNP
cord-265941-eff4le0g	79	22	-	-	HYPH
cord-265941-eff4le0g	79	23	β	β	NNP
cord-265941-eff4le0g	79	24	mRNA	mrna	NN
cord-265941-eff4le0g	79	25	expression	expression	NN
cord-265941-eff4le0g	79	26	,	,	,
cord-265941-eff4le0g	79	27	which	which	WDT
cord-265941-eff4le0g	79	28	facilitates	facilitate	VBZ
cord-265941-eff4le0g	79	29	IAV	IAV	NNP
cord-265941-eff4le0g	79	30	persistence	persistence	NN
cord-265941-eff4le0g	79	31	[	[	-LRB-
cord-265941-eff4le0g	79	32	19	19	CD
cord-265941-eff4le0g	79	33	,	,	,
cord-265941-eff4le0g	79	34	33	33	CD
cord-265941-eff4le0g	79	35	]	]	-RRB-
cord-265941-eff4le0g	79	36	.	.	.
cord-265941-eff4le0g	80	1	Interestingly	interestingly	RB
cord-265941-eff4le0g	80	2	,	,	,
cord-265941-eff4le0g	80	3	the	the	DT
cord-265941-eff4le0g	80	4	increased	increase	VBN
cord-265941-eff4le0g	80	5	RIPK3	ripk3	NN
cord-265941-eff4le0g	80	6	also	also	RB
cord-265941-eff4le0g	80	7	activates	activate	VBZ
cord-265941-eff4le0g	80	8	protein	protein	NN
cord-265941-eff4le0g	80	9	kinase	kinase	NN
cord-265941-eff4le0g	80	10	R	r	NN
cord-265941-eff4le0g	80	11	(	(	-LRB-
cord-265941-eff4le0g	80	12	PKR	PKR	NNP
cord-265941-eff4le0g	80	13	)	)	-RRB-
cord-265941-eff4le0g	80	14	that	that	WDT
cord-265941-eff4le0g	80	15	stabilises	stabilise	VBZ
cord-265941-eff4le0g	80	16	IFN	IFN	NNP
cord-265941-eff4le0g	80	17	-	-	HYPH
cord-265941-eff4le0g	80	18	β	β	NNP
cord-265941-eff4le0g	80	19	transcripts	transcript	NNS
cord-265941-eff4le0g	80	20	[	[	-LRB-
cord-265941-eff4le0g	80	21	34	34	CD
cord-265941-eff4le0g	80	22	]	]	-RRB-
cord-265941-eff4le0g	80	23	,	,	,
cord-265941-eff4le0g	80	24	thus	thus	RB
cord-265941-eff4le0g	80	25	elevating	elevate	VBG
cord-265941-eff4le0g	80	26	IFN	IFN	NNP
cord-265941-eff4le0g	80	27	-	-	HYPH
cord-265941-eff4le0g	80	28	β	β	NN
cord-265941-eff4le0g	80	29	production	production	NN
cord-265941-eff4le0g	80	30	and	and	CC
cord-265941-eff4le0g	80	31	type	type	NN
cord-265941-eff4le0g	81	1	I	-PRON-	PRP
cord-265941-eff4le0g	81	2	IFN	IFN	NNP
cord-265941-eff4le0g	81	3	protection	protection	NN
cord-265941-eff4le0g	81	4	[	[	-LRB-
cord-265941-eff4le0g	81	5	33	33	CD
cord-265941-eff4le0g	81	6	]	]	-RRB-
cord-265941-eff4le0g	81	7	.	.	.
cord-265941-eff4le0g	82	1	This	this	DT
cord-265941-eff4le0g	82	2	is	be	VBZ
cord-265941-eff4le0g	82	3	presumed	presume	VBN
cord-265941-eff4le0g	82	4	to	to	TO
cord-265941-eff4le0g	82	5	have	have	VB
cord-265941-eff4le0g	82	6	been	be	VBN
cord-265941-eff4le0g	82	7	counter	counter	RB
cord-265941-eff4le0g	82	8	-	-	VBN
cord-265941-eff4le0g	82	9	evolved	evolve	VBN
cord-265941-eff4le0g	82	10	by	by	IN
cord-265941-eff4le0g	82	11	hosts	host	NNS
cord-265941-eff4le0g	82	12	in	in	IN
cord-265941-eff4le0g	82	13	response	response	NN
cord-265941-eff4le0g	82	14	to	to	IN
cord-265941-eff4le0g	82	15	viral	viral	JJ
cord-265941-eff4le0g	82	16	evasion	evasion	NN
cord-265941-eff4le0g	82	17	and	and	CC
cord-265941-eff4le0g	82	18	represents	represent	VBZ
cord-265941-eff4le0g	82	19	a	a	DT
cord-265941-eff4le0g	82	20	potential	potential	JJ
cord-265941-eff4le0g	82	21	avenue	avenue	NN
cord-265941-eff4le0g	82	22	for	for	IN
cord-265941-eff4le0g	82	23	therapy	therapy	NN
cord-265941-eff4le0g	82	24	against	against	IN
cord-265941-eff4le0g	82	25	pathogenic	pathogenic	JJ
cord-265941-eff4le0g	82	26	IAV	IAV	NNP
cord-265941-eff4le0g	82	27	.	.	.
cord-265941-eff4le0g	83	1	Several	several	JJ
cord-265941-eff4le0g	83	2	other	other	JJ
cord-265941-eff4le0g	83	3	viruses	virus	NNS
cord-265941-eff4le0g	83	4	are	be	VBP
cord-265941-eff4le0g	83	5	known	know	VBN
cord-265941-eff4le0g	83	6	to	to	TO
cord-265941-eff4le0g	83	7	modulate	modulate	VB
cord-265941-eff4le0g	83	8	RIPK1/3	RIPK1/3	NNP
cord-265941-eff4le0g	83	9	signaling	signal	VBG
cord-265941-eff4le0g	83	10	in	in	IN
cord-265941-eff4le0g	83	11	non	non	JJ
cord-265941-eff4le0g	83	12	-	-	JJ
cord-265941-eff4le0g	83	13	cell	cell	JJ
cord-265941-eff4le0g	83	14	death	death	NN
cord-265941-eff4le0g	83	15	pathways	pathway	NNS
cord-265941-eff4le0g	83	16	to	to	TO
cord-265941-eff4le0g	83	17	benefit	benefit	VB
cord-265941-eff4le0g	83	18	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	83	19	.	.	.
cord-265941-eff4le0g	84	1	For	for	IN
cord-265941-eff4le0g	84	2	example	example	NN
cord-265941-eff4le0g	84	3	,	,	,
cord-265941-eff4le0g	84	4	the	the	DT
cord-265941-eff4le0g	84	5	common	common	JJ
cord-265941-eff4le0g	84	6	cause	cause	NN
cord-265941-eff4le0g	84	7	for	for	IN
cord-265941-eff4le0g	84	8	infectious	infectious	JJ
cord-265941-eff4le0g	84	9	mononucleosis	mononucleosis	NN
cord-265941-eff4le0g	84	10	,	,	,
cord-265941-eff4le0g	84	11	Epstein	Epstein	NNP
cord-265941-eff4le0g	84	12	-	-	HYPH
cord-265941-eff4le0g	84	13	Barr	Barr	NNP
cord-265941-eff4le0g	84	14	virus	virus	NN
cord-265941-eff4le0g	84	15	(	(	-LRB-
cord-265941-eff4le0g	84	16	EBV	EBV	NNP
cord-265941-eff4le0g	84	17	)	)	-RRB-
cord-265941-eff4le0g	84	18	,	,	,
cord-265941-eff4le0g	84	19	encodes	encode	VBZ
cord-265941-eff4le0g	84	20	a	a	DT
cord-265941-eff4le0g	84	21	latent	latent	JJ
cord-265941-eff4le0g	84	22	membrane	membrane	NN
cord-265941-eff4le0g	84	23	protein	protein	NN
cord-265941-eff4le0g	84	24	(	(	-LRB-
cord-265941-eff4le0g	84	25	LMP1	LMP1	NNP
cord-265941-eff4le0g	84	26	)	)	-RRB-
cord-265941-eff4le0g	84	27	that	that	WDT
cord-265941-eff4le0g	84	28	binds	bind	VBZ
cord-265941-eff4le0g	84	29	both	both	DT
cord-265941-eff4le0g	84	30	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	84	31	and	and	CC
cord-265941-eff4le0g	84	32	RIPK3	ripk3	NN
cord-265941-eff4le0g	84	33	,	,	,
cord-265941-eff4le0g	84	34	and	and	CC
cord-265941-eff4le0g	84	35	recruits	recruit	VBZ
cord-265941-eff4le0g	84	36	E3	e3	NN
cord-265941-eff4le0g	84	37	ligases	ligase	NNS
cord-265941-eff4le0g	84	38	to	to	TO
cord-265941-eff4le0g	84	39	regulate	regulate	VB
cord-265941-eff4le0g	84	40	protein	protein	NN
cord-265941-eff4le0g	84	41	ubiquitylation	ubiquitylation	NN
cord-265941-eff4le0g	84	42	[	[	-LRB-
cord-265941-eff4le0g	84	43	35	35	CD
cord-265941-eff4le0g	84	44	]	]	-RRB-
cord-265941-eff4le0g	84	45	.	.	.
cord-265941-eff4le0g	85	1	Consequently	consequently	RB
cord-265941-eff4le0g	85	2	,	,	,
cord-265941-eff4le0g	85	3	LMP1	LMP1	NNP
cord-265941-eff4le0g	85	4	promotes	promote	VBZ
cord-265941-eff4le0g	85	5	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	85	6	polyubiquitylation	polyubiquitylation	NN
cord-265941-eff4le0g	85	7	,	,	,
cord-265941-eff4le0g	85	8	while	while	IN
cord-265941-eff4le0g	85	9	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	85	10	polyubiquitylation	polyubiquitylation	NNP
cord-265941-eff4le0g	85	11	is	be	VBZ
cord-265941-eff4le0g	85	12	suppressed	suppress	VBN
cord-265941-eff4le0g	85	13	through	through	IN
cord-265941-eff4le0g	85	14	yet	yet	RB
cord-265941-eff4le0g	85	15	undefined	undefined	JJ
cord-265941-eff4le0g	85	16	means	mean	NNS
cord-265941-eff4le0g	85	17	,	,	,
cord-265941-eff4le0g	85	18	which	which	WDT
cord-265941-eff4le0g	85	19	switches	switch	VBZ
cord-265941-eff4le0g	85	20	cell	cell	NN
cord-265941-eff4le0g	85	21	fate	fate	NN
cord-265941-eff4le0g	85	22	from	from	IN
cord-265941-eff4le0g	85	23	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	85	24	to	to	IN
cord-265941-eff4le0g	85	25	survival	survival	NN
cord-265941-eff4le0g	85	26	.	.	.
cord-265941-eff4le0g	86	1	Human	human	JJ
cord-265941-eff4le0g	86	2	immunodeficiency	immunodeficiency	NN
cord-265941-eff4le0g	86	3	virus	virus	NN
cord-265941-eff4le0g	86	4	type	type	NN
cord-265941-eff4le0g	86	5	1	1	CD
cord-265941-eff4le0g	87	1	(	(	-LRB-
cord-265941-eff4le0g	87	2	HIV-1	HIV-1	NNP
cord-265941-eff4le0g	87	3	)	)	-RRB-
cord-265941-eff4le0g	87	4	protease	protease	NN
cord-265941-eff4le0g	87	5	(	(	-LRB-
cord-265941-eff4le0g	87	6	PR	PR	NNP
cord-265941-eff4le0g	87	7	)	)	-RRB-
cord-265941-eff4le0g	87	8	cleaves	cleave	VBZ
cord-265941-eff4le0g	87	9	RIPK1	ripk1	JJ
cord-265941-eff4le0g	87	10	with	with	IN
cord-265941-eff4le0g	87	11	high	high	JJ
cord-265941-eff4le0g	87	12	specificity	specificity	NN
cord-265941-eff4le0g	87	13	in	in	IN
cord-265941-eff4le0g	87	14	human	human	JJ
cord-265941-eff4le0g	87	15	T	t	NN
cord-265941-eff4le0g	87	16	lymphocytes	lymphocyte	NNS
cord-265941-eff4le0g	87	17	,	,	,
cord-265941-eff4le0g	87	18	resulting	result	VBG
cord-265941-eff4le0g	87	19	in	in	IN
cord-265941-eff4le0g	87	20	failure	failure	NN
cord-265941-eff4le0g	87	21	to	to	TO
cord-265941-eff4le0g	87	22	activate	activate	VB
cord-265941-eff4le0g	87	23	NF	NF	NNP
cord-265941-eff4le0g	87	24	-	-	HYPH
cord-265941-eff4le0g	87	25	ĸB	ĸB	NNP
cord-265941-eff4le0g	87	26	[	[	-LRB-
cord-265941-eff4le0g	87	27	35	35	CD
cord-265941-eff4le0g	87	28	]	]	-RRB-
cord-265941-eff4le0g	87	29	.	.	.
cord-265941-eff4le0g	88	1	Conversely	conversely	RB
cord-265941-eff4le0g	88	2	,	,	,
cord-265941-eff4le0g	88	3	coxsackievirus	coxsackievirus	NNP
cord-265941-eff4le0g	88	4	B3	B3	NNP
cord-265941-eff4le0g	88	5	(	(	-LRB-
cord-265941-eff4le0g	88	6	CVB	CVB	NNP
cord-265941-eff4le0g	88	7	)	)	-RRB-
cord-265941-eff4le0g	88	8	employs	employ	VBZ
cord-265941-eff4le0g	88	9	RIPK3	ripk3	NN
cord-265941-eff4le0g	88	10	to	to	TO
cord-265941-eff4le0g	88	11	promote	promote	VB
cord-265941-eff4le0g	88	12	autophagic	autophagic	NN
cord-265941-eff4le0g	88	13	flux	flux	NN
cord-265941-eff4le0g	88	14	for	for	IN
cord-265941-eff4le0g	88	15	viral	viral	JJ
cord-265941-eff4le0g	88	16	assembly	assembly	NN
cord-265941-eff4le0g	88	17	[	[	-LRB-
cord-265941-eff4le0g	88	18	36	36	CD
cord-265941-eff4le0g	88	19	]	]	-RRB-
cord-265941-eff4le0g	88	20	,	,	,
cord-265941-eff4le0g	88	21	and	and	CC
cord-265941-eff4le0g	88	22	as	as	RB
cord-265941-eff4le0g	88	23	such	such	JJ
cord-265941-eff4le0g	88	24	,	,	,
cord-265941-eff4le0g	88	25	silencing	silence	VBG
cord-265941-eff4le0g	88	26	of	of	IN
cord-265941-eff4le0g	88	27	RIPK3	ripk3	NN
cord-265941-eff4le0g	88	28	in	in	IN
cord-265941-eff4le0g	88	29	human	human	JJ
cord-265941-eff4le0g	88	30	intestinal	intestinal	JJ
cord-265941-eff4le0g	88	31	epithelial	epithelial	JJ
cord-265941-eff4le0g	88	32	cells	cell	NNS
cord-265941-eff4le0g	88	33	restricts	restrict	VBZ
cord-265941-eff4le0g	88	34	early	early	JJ
cord-265941-eff4le0g	88	35	viral	viral	JJ
cord-265941-eff4le0g	88	36	replication	replication	NN
cord-265941-eff4le0g	88	37	[	[	-LRB-
cord-265941-eff4le0g	88	38	37	37	CD
cord-265941-eff4le0g	88	39	]	]	-RRB-
cord-265941-eff4le0g	88	40	.	.	.
cord-265941-eff4le0g	89	1	Yersinia	Yersinia	NNP
cord-265941-eff4le0g	89	2	pestis	pestis	NN
cord-265941-eff4le0g	89	3	,	,	,
cord-265941-eff4le0g	89	4	the	the	DT
cord-265941-eff4le0g	89	5	etiological	etiological	JJ
cord-265941-eff4le0g	89	6	agent	agent	NN
cord-265941-eff4le0g	89	7	of	of	IN
cord-265941-eff4le0g	89	8	bubonic	bubonic	NNP
cord-265941-eff4le0g	89	9	plague	plague	NN
cord-265941-eff4le0g	89	10	,	,	,
cord-265941-eff4le0g	89	11	produces	produce	VBZ
cord-265941-eff4le0g	89	12	an	an	DT
cord-265941-eff4le0g	89	13	array	array	NN
cord-265941-eff4le0g	89	14	of	of	IN
cord-265941-eff4le0g	89	15	Yersinia	Yersinia	NNP
cord-265941-eff4le0g	89	16	outer	outer	JJ
cord-265941-eff4le0g	89	17	protein	protein	NN
cord-265941-eff4le0g	89	18	(	(	-LRB-
cord-265941-eff4le0g	89	19	Yop	Yop	NNP
cord-265941-eff4le0g	89	20	)	)	-RRB-
cord-265941-eff4le0g	89	21	virulence	virulence	NN
cord-265941-eff4le0g	89	22	effectors	effector	NNS
cord-265941-eff4le0g	89	23	that	that	WDT
cord-265941-eff4le0g	89	24	are	be	VBP
cord-265941-eff4le0g	89	25	translocated	translocate	VBN
cord-265941-eff4le0g	89	26	into	into	IN
cord-265941-eff4le0g	89	27	host	host	NN
cord-265941-eff4le0g	89	28	cells	cell	NNS
cord-265941-eff4le0g	89	29	via	via	IN
cord-265941-eff4le0g	89	30	a	a	DT
cord-265941-eff4le0g	89	31	type	type	NN
cord-265941-eff4le0g	89	32	III	iii	CD
cord-265941-eff4le0g	89	33	secretion	secretion	NN
cord-265941-eff4le0g	89	34	system	system	NN
cord-265941-eff4le0g	89	35	(	(	-LRB-
cord-265941-eff4le0g	89	36	T3SS	t3ss	NN
cord-265941-eff4le0g	89	37	)	)	-RRB-
cord-265941-eff4le0g	89	38	to	to	TO
cord-265941-eff4le0g	89	39	alter	alter	VB
cord-265941-eff4le0g	89	40	host	host	NN
cord-265941-eff4le0g	89	41	cell	cell	NN
cord-265941-eff4le0g	89	42	signaling	signal	VBG
cord-265941-eff4le0g	89	43	[	[	-LRB-
cord-265941-eff4le0g	89	44	38	38	CD
cord-265941-eff4le0g	89	45	]	]	-RRB-
cord-265941-eff4le0g	89	46	.	.	.
cord-265941-eff4le0g	90	1	Infection	infection	NN
cord-265941-eff4le0g	90	2	of	of	IN
cord-265941-eff4le0g	90	3	macrophages	macrophage	NNS
cord-265941-eff4le0g	90	4	with	with	IN
cord-265941-eff4le0g	90	5	Y.	Y.	NNP
cord-265941-eff4le0g	90	6	pestis	pestis	NN
cord-265941-eff4le0g	90	7	results	result	NNS
cord-265941-eff4le0g	90	8	in	in	IN
cord-265941-eff4le0g	90	9	TNF	TNF	NNP
cord-265941-eff4le0g	90	10	,	,	,
cord-265941-eff4le0g	90	11	IL-6	IL-6	NNP
cord-265941-eff4le0g	90	12	and	and	CC
cord-265941-eff4le0g	90	13	IL-1β	IL-1β	NNP
cord-265941-eff4le0g	90	14	secretion	secretion	NN
cord-265941-eff4le0g	90	15	,	,	,
cord-265941-eff4le0g	90	16	mediated	mediate	VBN
cord-265941-eff4le0g	90	17	through	through	IN
cord-265941-eff4le0g	90	18	a	a	DT
cord-265941-eff4le0g	90	19	RIPK1	ripk1	NN
cord-265941-eff4le0g	90	20	and	and	CC
cord-265941-eff4le0g	90	21	caspase-8	caspase-8	JJ
cord-265941-eff4le0g	90	22	dependent	dependent	JJ
cord-265941-eff4le0g	90	23	,	,	,
cord-265941-eff4le0g	91	1	but	but	CC
cord-265941-eff4le0g	91	2	RIPK3-independent	ripk3-independent	CD
cord-265941-eff4le0g	91	3	mechanism	mechanism	NN
cord-265941-eff4le0g	91	4	[	[	-LRB-
cord-265941-eff4le0g	91	5	39	39	CD
cord-265941-eff4le0g	91	6	]	]	-RRB-
cord-265941-eff4le0g	91	7	.	.	.
cord-265941-eff4le0g	92	1	As	as	IN
cord-265941-eff4le0g	92	2	a	a	DT
cord-265941-eff4le0g	92	3	result	result	NN
cord-265941-eff4le0g	92	4	,	,	,
cord-265941-eff4le0g	92	5	RIPK1	ripk1	JJ
cord-265941-eff4le0g	92	6	deletion	deletion	NN
cord-265941-eff4le0g	92	7	in	in	IN
cord-265941-eff4le0g	92	8	murine	murine	JJ
cord-265941-eff4le0g	92	9	myeloid	myeloid	NN
cord-265941-eff4le0g	92	10	cells	cell	NNS
cord-265941-eff4le0g	92	11	causes	cause	VBZ
cord-265941-eff4le0g	92	12	defective	defective	JJ
cord-265941-eff4le0g	92	13	cytokine	cytokine	NN
cord-265941-eff4le0g	92	14	release	release	NN
cord-265941-eff4le0g	92	15	,	,	,
cord-265941-eff4le0g	92	16	associated	associate	VBN
cord-265941-eff4le0g	92	17	with	with	IN
cord-265941-eff4le0g	92	18	decreased	decrease	VBN
cord-265941-eff4le0g	92	19	IĸBα	iĸbα	JJ
cord-265941-eff4le0g	92	20	degradation	degradation	NN
cord-265941-eff4le0g	92	21	and	and	CC
cord-265941-eff4le0g	92	22	NF	nf	NN
cord-265941-eff4le0g	92	23	-	-	HYPH
cord-265941-eff4le0g	92	24	ĸB	ĸB	NNP
cord-265941-eff4le0g	92	25	nuclear	nuclear	JJ
cord-265941-eff4le0g	92	26	translocation	translocation	NN
cord-265941-eff4le0g	92	27	.	.	.
cord-265941-eff4le0g	93	1	In	in	IN
cord-265941-eff4le0g	93	2	the	the	DT
cord-265941-eff4le0g	93	3	absence	absence	NN
cord-265941-eff4le0g	93	4	of	of	IN
cord-265941-eff4le0g	93	5	caspase	caspase	NN
cord-265941-eff4le0g	93	6	activity	activity	NN
cord-265941-eff4le0g	93	7	,	,	,
cord-265941-eff4le0g	93	8	Y.	Y.	NNP
cord-265941-eff4le0g	93	9	pseudotuberculosis	pseudotuberculosis	NN
cord-265941-eff4le0g	93	10	is	be	VBZ
cord-265941-eff4le0g	93	11	also	also	RB
cord-265941-eff4le0g	93	12	shown	show	VBN
cord-265941-eff4le0g	93	13	to	to	TO
cord-265941-eff4le0g	93	14	induce	induce	VB
cord-265941-eff4le0g	93	15	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	93	16	/	/	SYM
cord-265941-eff4le0g	93	17	RIPK3	ripk3	NN
cord-265941-eff4le0g	93	18	/	/	SYM
cord-265941-eff4le0g	93	19	TRIF	TRIF	NNP
cord-265941-eff4le0g	93	20	-	-	HYPH
cord-265941-eff4le0g	93	21	mediated	mediate	VBN
cord-265941-eff4le0g	93	22	synthesis	synthesis	NN
cord-265941-eff4le0g	93	23	of	of	IN
cord-265941-eff4le0g	93	24	IFN	IFN	NNP
cord-265941-eff4le0g	93	25	-	-	HYPH
cord-265941-eff4le0g	93	26	β	β	NNP
cord-265941-eff4le0g	93	27	in	in	IN
cord-265941-eff4le0g	93	28	macrophages	macrophage	NNS
cord-265941-eff4le0g	93	29	,	,	,
cord-265941-eff4le0g	93	30	similar	similar	JJ
cord-265941-eff4le0g	93	31	to	to	IN
cord-265941-eff4le0g	93	32	Klebsiella	Klebsiella	NNP
cord-265941-eff4le0g	93	33	pneumoniae	pneumoniae	NN
cord-265941-eff4le0g	93	34	[	[	-LRB-
cord-265941-eff4le0g	93	35	17	17	CD
cord-265941-eff4le0g	93	36	]	]	-RRB-
cord-265941-eff4le0g	93	37	.	.	.
cord-265941-eff4le0g	94	1	This	this	DT
cord-265941-eff4le0g	94	2	process	process	NN
cord-265941-eff4le0g	94	3	requires	require	VBZ
cord-265941-eff4le0g	94	4	the	the	DT
cord-265941-eff4le0g	94	5	kinase	kinase	NN
cord-265941-eff4le0g	94	6	activity	activity	NN
cord-265941-eff4le0g	94	7	of	of	IN
cord-265941-eff4le0g	94	8	both	both	DT
cord-265941-eff4le0g	94	9	RIPKs	ripk	NNS
cord-265941-eff4le0g	94	10	but	but	CC
cord-265941-eff4le0g	94	11	operates	operate	VBZ
cord-265941-eff4le0g	94	12	independently	independently	RB
cord-265941-eff4le0g	94	13	of	of	IN
cord-265941-eff4le0g	94	14	MLKL	MLKL	NNP
cord-265941-eff4le0g	94	15	-	-	HYPH
cord-265941-eff4le0g	94	16	mediated	mediate	VBN
cord-265941-eff4le0g	94	17	necroptosis	necroptosis	NN
cord-265941-eff4le0g	94	18	and	and	CC
cord-265941-eff4le0g	94	19	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	94	20	apoptosis	apoptosis	NN
cord-265941-eff4le0g	94	21	.	.	.
cord-265941-eff4le0g	95	1	To	to	TO
cord-265941-eff4le0g	95	2	counter	counter	VB
cord-265941-eff4le0g	95	3	host	host	NN
cord-265941-eff4le0g	95	4	inflammation	inflammation	NN
cord-265941-eff4le0g	95	5	,	,	,
cord-265941-eff4le0g	95	6	Y.	Y.	NNP
cord-265941-eff4le0g	95	7	pestis	pestis	NN
cord-265941-eff4le0g	95	8	encodes	encode	VBZ
cord-265941-eff4le0g	95	9	YopJ	YopJ	NNP
cord-265941-eff4le0g	95	10	,	,	,
cord-265941-eff4le0g	95	11	which	which	WDT
cord-265941-eff4le0g	95	12	acetylates	acetylate	VBZ
cord-265941-eff4le0g	95	13	MAPKs	MAPKs	NNP
cord-265941-eff4le0g	95	14	,	,	,
cord-265941-eff4le0g	95	15	IKKβ	IKKβ	NNP
cord-265941-eff4le0g	95	16	and	and	CC
cord-265941-eff4le0g	95	17	TAK1	TAK1	NNP
cord-265941-eff4le0g	95	18	within	within	IN
cord-265941-eff4le0g	95	19	their	-PRON-	PRP$
cord-265941-eff4le0g	95	20	activation	activation	NN
cord-265941-eff4le0g	95	21	loops	loop	NNS
cord-265941-eff4le0g	95	22	,	,	,
cord-265941-eff4le0g	95	23	thus	thus	RB
cord-265941-eff4le0g	95	24	dampening	dampen	VBG
cord-265941-eff4le0g	95	25	host	host	NN
cord-265941-eff4le0g	95	26	MAPK	MAPK	NNP
cord-265941-eff4le0g	95	27	and	and	CC
cord-265941-eff4le0g	95	28	NF	nf	NN
cord-265941-eff4le0g	95	29	-	-	HYPH
cord-265941-eff4le0g	95	30	ĸB	ĸB	NNP
cord-265941-eff4le0g	96	1	signaling	signal	VBG
cord-265941-eff4le0g	96	2	[	[	-LRB-
cord-265941-eff4le0g	96	3	40	40	CD
cord-265941-eff4le0g	96	4	]	]	-RRB-
cord-265941-eff4le0g	96	5	.	.	.
cord-265941-eff4le0g	97	1	Legionella	Legionella	NNP
cord-265941-eff4le0g	97	2	pneumophila	pneumophila	NN
cord-265941-eff4le0g	97	3	is	be	VBZ
cord-265941-eff4le0g	97	4	an	an	DT
cord-265941-eff4le0g	97	5	environmental	environmental	JJ
cord-265941-eff4le0g	97	6	organism	organism	NN
cord-265941-eff4le0g	97	7	and	and	CC
cord-265941-eff4le0g	97	8	accidental	accidental	JJ
cord-265941-eff4le0g	97	9	human	human	JJ
cord-265941-eff4le0g	97	10	pathogen	pathogen	NN
cord-265941-eff4le0g	97	11	that	that	WDT
cord-265941-eff4le0g	97	12	causes	cause	VBZ
cord-265941-eff4le0g	97	13	Legionnaires	legionnaire	NNS
cord-265941-eff4le0g	97	14	'	'	POS
cord-265941-eff4le0g	97	15	disease	disease	NN
cord-265941-eff4le0g	97	16	,	,	,
cord-265941-eff4le0g	97	17	a	a	DT
cord-265941-eff4le0g	97	18	severe	severe	JJ
cord-265941-eff4le0g	97	19	form	form	NN
cord-265941-eff4le0g	97	20	of	of	IN
cord-265941-eff4le0g	97	21	acute	acute	JJ
cord-265941-eff4le0g	97	22	pneumonia	pneumonia	NN
cord-265941-eff4le0g	97	23	[	[	-LRB-
cord-265941-eff4le0g	97	24	41	41	CD
cord-265941-eff4le0g	97	25	]	]	-RRB-
cord-265941-eff4le0g	97	26	.	.	.
cord-265941-eff4le0g	98	1	Following	follow	VBG
cord-265941-eff4le0g	98	2	infection	infection	NN
cord-265941-eff4le0g	98	3	,	,	,
cord-265941-eff4le0g	98	4	L.	L.	NNP
cord-265941-eff4le0g	98	5	pneumophila	pneumophila	NN
cord-265941-eff4le0g	98	6	effector	effector	JJ
cord-265941-eff4le0g	98	7	MavC	MavC	NNP
cord-265941-eff4le0g	98	8	(	(	-LRB-
cord-265941-eff4le0g	98	9	also	also	RB
cord-265941-eff4le0g	98	10	known	know	VBN
cord-265941-eff4le0g	98	11	as	as	IN
cord-265941-eff4le0g	98	12	Lpg2147	Lpg2147	NNP
cord-265941-eff4le0g	98	13	)	)	-RRB-
cord-265941-eff4le0g	98	14	deamidates	deamidate	VBZ
cord-265941-eff4le0g	98	15	the	the	DT
cord-265941-eff4le0g	98	16	human	human	JJ
cord-265941-eff4le0g	98	17	ubiquitin	ubiquitin	NN
cord-265941-eff4le0g	98	18	-	-	HYPH
cord-265941-eff4le0g	98	19	conjugating	conjugate	VBG
cord-265941-eff4le0g	98	20	enzyme	enzyme	NN
cord-265941-eff4le0g	98	21	E2N	E2N	NNP
cord-265941-eff4le0g	98	22	(	(	-LRB-
cord-265941-eff4le0g	98	23	UBE2N	UBE2N	NNP
cord-265941-eff4le0g	98	24	)	)	-RRB-
cord-265941-eff4le0g	98	25	,	,	,
cord-265941-eff4le0g	98	26	which	which	WDT
cord-265941-eff4le0g	98	27	disrupts	disrupt	VBZ
cord-265941-eff4le0g	98	28	UBE2N	ube2n	NN
cord-265941-eff4le0g	98	29	-	-	HYPH
cord-265941-eff4le0g	98	30	mediated	mediate	VBN
cord-265941-eff4le0g	98	31	formation	formation	NN
cord-265941-eff4le0g	98	32	of	of	IN
cord-265941-eff4le0g	98	33	Lys63	Lys63	NNP
cord-265941-eff4le0g	98	34	polyubiquitin	polyubiquitin	NNS
cord-265941-eff4le0g	98	35	chains	chain	NNS
cord-265941-eff4le0g	98	36	[	[	-LRB-
cord-265941-eff4le0g	98	37	42	42	CD
cord-265941-eff4le0g	98	38	]	]	-RRB-
cord-265941-eff4le0g	98	39	.	.	.
cord-265941-eff4le0g	99	1	This	this	DT
cord-265941-eff4le0g	99	2	prevents	prevent	VBZ
cord-265941-eff4le0g	99	3	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	99	4	polyubiquitylation	polyubiquitylation	NN
cord-265941-eff4le0g	99	5	,	,	,
cord-265941-eff4le0g	99	6	thus	thus	RB
cord-265941-eff4le0g	99	7	suppressing	suppress	VBG
cord-265941-eff4le0g	99	8	downstream	downstream	JJ
cord-265941-eff4le0g	99	9	NF	nf	NN
cord-265941-eff4le0g	99	10	-	-	HYPH
cord-265941-eff4le0g	99	11	ĸB	ĸB	NNP
cord-265941-eff4le0g	99	12	signaling	signaling	NN
cord-265941-eff4le0g	99	13	in	in	IN
cord-265941-eff4le0g	99	14	infected	infected	JJ
cord-265941-eff4le0g	99	15	cells	cell	NNS
cord-265941-eff4le0g	99	16	in	in	IN
cord-265941-eff4le0g	99	17	vitro	vitro	FW
cord-265941-eff4le0g	99	18	.	.	.
cord-265941-eff4le0g	100	1	Given	give	VBN
cord-265941-eff4le0g	100	2	the	the	DT
cord-265941-eff4le0g	100	3	presence	presence	NN
cord-265941-eff4le0g	100	4	of	of	IN
cord-265941-eff4le0g	100	5	MavC	MavC	NNP
cord-265941-eff4le0g	100	6	homologues	homologue	NNS
cord-265941-eff4le0g	100	7	in	in	IN
cord-265941-eff4le0g	100	8	the	the	DT
cord-265941-eff4le0g	100	9	cycle	cycle	NN
cord-265941-eff4le0g	100	10	inhibiting	inhibit	VBG
cord-265941-eff4le0g	100	11	factor	factor	NN
cord-265941-eff4le0g	100	12	(	(	-LRB-
cord-265941-eff4le0g	100	13	Cif	Cif	NNP
cord-265941-eff4le0g	100	14	)	)	-RRB-
cord-265941-eff4le0g	100	15	effector	effector	VBP
cord-265941-eff4le0g	100	16	family	family	NN
cord-265941-eff4le0g	100	17	of	of	IN
cord-265941-eff4le0g	100	18	T3SS	T3SS	NNP
cord-265941-eff4le0g	100	19	pathogens	pathogen	NNS
cord-265941-eff4le0g	100	20	[	[	-LRB-
cord-265941-eff4le0g	100	21	43	43	CD
cord-265941-eff4le0g	100	22	,	,	,
cord-265941-eff4le0g	100	23	44	44	CD
cord-265941-eff4le0g	100	24	]	]	-RRB-
cord-265941-eff4le0g	100	25	,	,	,
cord-265941-eff4le0g	100	26	there	there	EX
cord-265941-eff4le0g	100	27	may	may	MD
cord-265941-eff4le0g	100	28	be	be	VB
cord-265941-eff4le0g	100	29	similar	similar	JJ
cord-265941-eff4le0g	100	30	routes	route	NNS
cord-265941-eff4le0g	100	31	for	for	IN
cord-265941-eff4le0g	100	32	RIPK1	ripk1	JJ
cord-265941-eff4le0g	100	33	inhibition	inhibition	NN
cord-265941-eff4le0g	100	34	in	in	IN
cord-265941-eff4le0g	100	35	other	other	JJ
cord-265941-eff4le0g	100	36	bacterial	bacterial	JJ
cord-265941-eff4le0g	100	37	contexts	context	NNS
cord-265941-eff4le0g	100	38	.	.	.
cord-265941-eff4le0g	101	1	Bacterial	bacterial	JJ
cord-265941-eff4le0g	101	2	effectors	effector	NNS
cord-265941-eff4le0g	101	3	can	can	MD
cord-265941-eff4le0g	101	4	also	also	RB
cord-265941-eff4le0g	101	5	directly	directly	RB
cord-265941-eff4le0g	101	6	manipulate	manipulate	VB
cord-265941-eff4le0g	101	7	RIPKs	ripks	PRP
cord-265941-eff4le0g	101	8	.	.	.
cord-265941-eff4le0g	102	1	Enteropathogenic	Enteropathogenic	NNP
cord-265941-eff4le0g	102	2	Escherichia	escherichia	NN
cord-265941-eff4le0g	102	3	coli	coli	NNS
cord-265941-eff4le0g	102	4	(	(	-LRB-
cord-265941-eff4le0g	102	5	EPEC	EPEC	NNP
cord-265941-eff4le0g	102	6	)	)	-RRB-
cord-265941-eff4le0g	102	7	encodes	encode	VBZ
cord-265941-eff4le0g	102	8	an	an	DT
cord-265941-eff4le0g	102	9	arginine	arginine	NN
cord-265941-eff4le0g	102	10	glycosyltransferase	glycosyltransferase	NN
cord-265941-eff4le0g	102	11	,	,	,
cord-265941-eff4le0g	102	12	NleB1	NleB1	NNP
cord-265941-eff4le0g	102	13	,	,	,
cord-265941-eff4le0g	102	14	that	that	WDT
cord-265941-eff4le0g	102	15	modifies	modify	VBZ
cord-265941-eff4le0g	102	16	RIPK1	ripk1	JJ
cord-265941-eff4le0g	102	17	following	follow	VBG
cord-265941-eff4le0g	102	18	infection	infection	NN
cord-265941-eff4le0g	102	19	of	of	IN
cord-265941-eff4le0g	102	20	human	human	JJ
cord-265941-eff4le0g	102	21	cells	cell	NNS
cord-265941-eff4le0g	102	22	[	[	-LRB-
cord-265941-eff4le0g	102	23	45	45	CD
cord-265941-eff4le0g	102	24	,	,	,
cord-265941-eff4le0g	102	25	46	46	CD
cord-265941-eff4le0g	102	26	]	]	-RRB-
cord-265941-eff4le0g	102	27	.	.	.
cord-265941-eff4le0g	103	1	This	this	DT
cord-265941-eff4le0g	103	2	activity	activity	NN
cord-265941-eff4le0g	103	3	inhibits	inhibit	VBZ
cord-265941-eff4le0g	103	4	the	the	DT
cord-265941-eff4le0g	103	5	recruitment	recruitment	NN
cord-265941-eff4le0g	103	6	of	of	IN
cord-265941-eff4le0g	103	7	ubiquitinated	ubiquitinated	JJ
cord-265941-eff4le0g	103	8	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	103	9	to	to	IN
cord-265941-eff4le0g	103	10	TNFR1	TNFR1	NNP
cord-265941-eff4le0g	103	11	,	,	,
cord-265941-eff4le0g	103	12	thus	thus	RB
cord-265941-eff4le0g	103	13	disrupting	disrupt	VBG
cord-265941-eff4le0g	103	14	the	the	DT
cord-265941-eff4le0g	103	15	assembly	assembly	NN
cord-265941-eff4le0g	103	16	of	of	IN
cord-265941-eff4le0g	103	17	Complex	Complex	NNP
cord-265941-eff4le0g	104	1	I	-PRON-	PRP
cord-265941-eff4le0g	104	2	required	require	VBD
cord-265941-eff4le0g	104	3	for	for	IN
cord-265941-eff4le0g	105	1	TNF	TNF	NNP
cord-265941-eff4le0g	105	2	-	-	HYPH
cord-265941-eff4le0g	105	3	induced	induce	VBN
cord-265941-eff4le0g	105	4	NF	nf	NN
cord-265941-eff4le0g	105	5	-	-	HYPH
cord-265941-eff4le0g	105	6	ĸB	ĸB	NNP
cord-265941-eff4le0g	105	7	signaling	signal	VBG
cord-265941-eff4le0g	105	8	[	[	-LRB-
cord-265941-eff4le0g	105	9	45	45	CD
cord-265941-eff4le0g	105	10	]	]	-RRB-
cord-265941-eff4le0g	105	11	.	.	.
cord-265941-eff4le0g	106	1	Although	although	IN
cord-265941-eff4le0g	106	2	transient	transient	JJ
cord-265941-eff4le0g	106	3	expression	expression	NN
cord-265941-eff4le0g	106	4	of	of	IN
cord-265941-eff4le0g	106	5	NleB1	NleB1	NNP
cord-265941-eff4le0g	106	6	inhibits	inhibit	VBZ
cord-265941-eff4le0g	106	7	NF	nf	NN
cord-265941-eff4le0g	106	8	-	-	HYPH
cord-265941-eff4le0g	106	9	ĸB	ĸb	NN
cord-265941-eff4le0g	106	10	activation	activation	NN
cord-265941-eff4le0g	106	11	[	[	-LRB-
cord-265941-eff4le0g	106	12	47	47	CD
cord-265941-eff4le0g	106	13	]	]	-RRB-
cord-265941-eff4le0g	106	14	,	,	,
cord-265941-eff4le0g	106	15	NleB1	NleB1	NNP
cord-265941-eff4le0g	106	16	alone	alone	RB
cord-265941-eff4le0g	106	17	is	be	VBZ
cord-265941-eff4le0g	106	18	not	not	RB
cord-265941-eff4le0g	106	19	sufficient	sufficient	JJ
cord-265941-eff4le0g	106	20	to	to	TO
cord-265941-eff4le0g	106	21	inhibit	inhibit	VB
cord-265941-eff4le0g	106	22	NF	nf	NN
cord-265941-eff4le0g	106	23	-	-	HYPH
cord-265941-eff4le0g	106	24	ĸB	ĸb	NN
cord-265941-eff4le0g	106	25	-	-	HYPH
cord-265941-eff4le0g	106	26	mediated	mediate	VBN
cord-265941-eff4le0g	106	27	IL-8	il-8	NN
cord-265941-eff4le0g	106	28	production	production	NN
cord-265941-eff4le0g	106	29	during	during	IN
cord-265941-eff4le0g	106	30	EPEC	EPEC	NNP
cord-265941-eff4le0g	106	31	infection	infection	NN
cord-265941-eff4le0g	106	32	in	in	IN
cord-265941-eff4le0g	106	33	vitro	vitro	FW
cord-265941-eff4le0g	106	34	[	[	-LRB-
cord-265941-eff4le0g	106	35	46	46	CD
cord-265941-eff4le0g	106	36	]	]	-RRB-
cord-265941-eff4le0g	106	37	,	,	,
cord-265941-eff4le0g	106	38	as	as	IN
cord-265941-eff4le0g	106	39	multiple	multiple	JJ
cord-265941-eff4le0g	106	40	effectors	effector	NNS
cord-265941-eff4le0g	106	41	are	be	VBP
cord-265941-eff4le0g	106	42	required	require	VBN
cord-265941-eff4le0g	106	43	to	to	TO
cord-265941-eff4le0g	106	44	achieve	achieve	VB
cord-265941-eff4le0g	106	45	this	this	DT
cord-265941-eff4le0g	106	46	outcome	outcome	NN
cord-265941-eff4le0g	106	47	[	[	-LRB-
cord-265941-eff4le0g	106	48	48	48	CD
cord-265941-eff4le0g	106	49	]	]	-RRB-
cord-265941-eff4le0g	106	50	.	.	.
cord-265941-eff4le0g	107	1	Apoptosis	apoptosis	NN
cord-265941-eff4le0g	107	2	is	be	VBZ
cord-265941-eff4le0g	107	3	a	a	DT
cord-265941-eff4le0g	107	4	common	common	JJ
cord-265941-eff4le0g	107	5	host	host	NN
cord-265941-eff4le0g	107	6	response	response	NN
cord-265941-eff4le0g	107	7	to	to	IN
cord-265941-eff4le0g	107	8	infection	infection	NN
cord-265941-eff4le0g	107	9	that	that	WDT
cord-265941-eff4le0g	107	10	helps	help	VBZ
cord-265941-eff4le0g	107	11	restrict	restrict	VB
cord-265941-eff4le0g	107	12	the	the	DT
cord-265941-eff4le0g	107	13	replicative	replicative	JJ
cord-265941-eff4le0g	107	14	niche	niche	NN
cord-265941-eff4le0g	107	15	of	of	IN
cord-265941-eff4le0g	107	16	pathogens	pathogen	NNS
cord-265941-eff4le0g	107	17	,	,	,
cord-265941-eff4le0g	107	18	and	and	CC
cord-265941-eff4le0g	107	19	facilitates	facilitate	VBZ
cord-265941-eff4le0g	107	20	phagocytosis	phagocytosis	NN
cord-265941-eff4le0g	107	21	and	and	CC
cord-265941-eff4le0g	107	22	antigen	antigen	NN
cord-265941-eff4le0g	107	23	presentation	presentation	NN
cord-265941-eff4le0g	107	24	through	through	IN
cord-265941-eff4le0g	107	25	the	the	DT
cord-265941-eff4le0g	107	26	production	production	NN
cord-265941-eff4le0g	107	27	of	of	IN
cord-265941-eff4le0g	107	28	apoptotic	apoptotic	JJ
cord-265941-eff4le0g	107	29	bodies	body	NNS
cord-265941-eff4le0g	107	30	[	[	-LRB-
cord-265941-eff4le0g	107	31	49	49	CD
cord-265941-eff4le0g	107	32	]	]	-RRB-
cord-265941-eff4le0g	107	33	.	.	.
cord-265941-eff4le0g	108	1	Many	many	JJ
cord-265941-eff4le0g	108	2	pathogens	pathogen	NNS
cord-265941-eff4le0g	108	3	however	however	RB
cord-265941-eff4le0g	108	4	,	,	,
cord-265941-eff4le0g	108	5	have	have	VBP
cord-265941-eff4le0g	108	6	evolved	evolve	VBN
cord-265941-eff4le0g	108	7	mechanisms	mechanism	NNS
cord-265941-eff4le0g	108	8	to	to	TO
cord-265941-eff4le0g	108	9	manipulate	manipulate	VB
cord-265941-eff4le0g	108	10	apoptotic	apoptotic	JJ
cord-265941-eff4le0g	108	11	processes	process	NNS
cord-265941-eff4le0g	108	12	to	to	TO
cord-265941-eff4le0g	108	13	benefit	benefit	VB
cord-265941-eff4le0g	108	14	survival	survival	NN
cord-265941-eff4le0g	108	15	and	and	CC
cord-265941-eff4le0g	108	16	virulence	virulence	NN
cord-265941-eff4le0g	108	17	(	(	-LRB-
cord-265941-eff4le0g	108	18	Fig	fig	NN
cord-265941-eff4le0g	108	19	.	.	NNP
cord-265941-eff4le0g	108	20	2	2	CD
cord-265941-eff4le0g	108	21	)	)	-RRB-
cord-265941-eff4le0g	108	22	.	.	.
cord-265941-eff4le0g	108	23	 	 	_SP
cord-265941-eff4le0g	109	1	The	the	DT
cord-265941-eff4le0g	109	2	execution	execution	NN
cord-265941-eff4le0g	109	3	of	of	IN
cord-265941-eff4le0g	109	4	apoptosis	apoptosis	NN
cord-265941-eff4le0g	109	5	is	be	VBZ
cord-265941-eff4le0g	109	6	heavily	heavily	RB
cord-265941-eff4le0g	109	7	reliant	reliant	JJ
cord-265941-eff4le0g	109	8	on	on	IN
cord-265941-eff4le0g	109	9	host	host	NN
cord-265941-eff4le0g	109	10	caspases	caspase	NNS
cord-265941-eff4le0g	109	11	,	,	,
cord-265941-eff4le0g	109	12	thus	thus	RB
cord-265941-eff4le0g	109	13	most	most	RBS
cord-265941-eff4le0g	109	14	large	large	JJ
cord-265941-eff4le0g	109	15	DNA	dna	NN
cord-265941-eff4le0g	109	16	viruses	virus	NNS
cord-265941-eff4le0g	109	17	encode	encode	VBP
cord-265941-eff4le0g	109	18	effectors	effector	NNS
cord-265941-eff4le0g	109	19	for	for	IN
cord-265941-eff4le0g	109	20	inhibiting	inhibit	VBG
cord-265941-eff4le0g	109	21	caspase	caspase	NN
cord-265941-eff4le0g	109	22	activity	activity	NN
cord-265941-eff4le0g	109	23	[	[	-LRB-
cord-265941-eff4le0g	109	24	70	70	CD
cord-265941-eff4le0g	109	25	]	]	-RRB-
cord-265941-eff4le0g	109	26	,	,	,
cord-265941-eff4le0g	109	27	however	however	RB
cord-265941-eff4le0g	109	28	,	,	,
cord-265941-eff4le0g	109	29	few	few	JJ
cord-265941-eff4le0g	109	30	viral	viral	JJ
cord-265941-eff4le0g	109	31	factors	factor	NNS
cord-265941-eff4le0g	109	32	target	target	VBP
cord-265941-eff4le0g	109	33	RIPKs	ripks	RB
cord-265941-eff4le0g	109	34	directly	directly	RB
cord-265941-eff4le0g	109	35	.	.	.
cord-265941-eff4le0g	110	1	Herpes	Herpes	NNP
cord-265941-eff4le0g	110	2	simplex	simplex	NN
cord-265941-eff4le0g	110	3	virus	virus	NN
cord-265941-eff4le0g	110	4	(	(	-LRB-
cord-265941-eff4le0g	110	5	HSV	HSV	NNP
cord-265941-eff4le0g	110	6	)	)	-RRB-
cord-265941-eff4le0g	110	7	contains	contain	VBZ
cord-265941-eff4le0g	110	8	numerous	numerous	JJ
cord-265941-eff4le0g	110	9	proteins	protein	NNS
cord-265941-eff4le0g	110	10	that	that	WDT
cord-265941-eff4le0g	110	11	can	can	MD
cord-265941-eff4le0g	110	12	interact	interact	VB
cord-265941-eff4le0g	110	13	with	with	IN
cord-265941-eff4le0g	110	14	apoptotic	apoptotic	JJ
cord-265941-eff4le0g	110	15	signaling	signal	VBG
cord-265941-eff4le0g	110	16	components	component	NNS
cord-265941-eff4le0g	110	17	,	,	,
cord-265941-eff4le0g	110	18	including	include	VBG
cord-265941-eff4le0g	110	19	ICP6	ICP6	NNP
cord-265941-eff4le0g	110	20	and	and	CC
cord-265941-eff4le0g	110	21	ICP10	ICP10	NNP
cord-265941-eff4le0g	110	22	encoded	encode	VBN
cord-265941-eff4le0g	110	23	by	by	IN
cord-265941-eff4le0g	110	24	HSV-1	hsv-1	NN
cord-265941-eff4le0g	110	25	and	and	CC
cord-265941-eff4le0g	110	26	HSV-2	HSV-2	NNP
cord-265941-eff4le0g	110	27	respectively	respectively	RB
cord-265941-eff4le0g	110	28	[	[	-LRB-
cord-265941-eff4le0g	110	29	71	71	CD
cord-265941-eff4le0g	110	30	]	]	-RRB-
cord-265941-eff4le0g	110	31	.	.	.
cord-265941-eff4le0g	111	1	These	these	DT
cord-265941-eff4le0g	111	2	proteins	protein	NNS
cord-265941-eff4le0g	111	3	possess	possess	VBP
cord-265941-eff4le0g	111	4	a	a	DT
cord-265941-eff4le0g	111	5	C	c	NN
cord-265941-eff4le0g	111	6	-	-	HYPH
cord-265941-eff4le0g	111	7	terminal	terminal	NN
cord-265941-eff4le0g	111	8	RR	rr	NN
cord-265941-eff4le0g	111	9	domain	domain	NN
cord-265941-eff4le0g	111	10	that	that	WDT
cord-265941-eff4le0g	111	11	inhibits	inhibit	VBZ
cord-265941-eff4le0g	111	12	caspase-8	caspase-8	JJ
cord-265941-eff4le0g	111	13	function	function	NN
cord-265941-eff4le0g	111	14	,	,	,
cord-265941-eff4le0g	111	15	thus	thus	RB
cord-265941-eff4le0g	111	16	suppressing	suppress	VBG
cord-265941-eff4le0g	111	17	TNF	TNF	NNP
cord-265941-eff4le0g	111	18	and	and	CC
cord-265941-eff4le0g	111	19	Fas	Fas	NNP
cord-265941-eff4le0g	111	20	-	-	HYPH
cord-265941-eff4le0g	111	21	induced	induce	VBN
cord-265941-eff4le0g	111	22	apoptosis	apoptosis	NN
cord-265941-eff4le0g	111	23	[	[	-LRB-
cord-265941-eff4le0g	111	24	72	72	CD
cord-265941-eff4le0g	111	25	]	]	-RRB-
cord-265941-eff4le0g	111	26	.	.	.
cord-265941-eff4le0g	112	1	Curiously	curiously	RB
cord-265941-eff4le0g	112	2	,	,	,
cord-265941-eff4le0g	112	3	this	this	DT
cord-265941-eff4le0g	112	4	C	c	NN
cord-265941-eff4le0g	112	5	-	-	HYPH
cord-265941-eff4le0g	112	6	terminal	terminal	NN
cord-265941-eff4le0g	112	7	RR	rr	NN
cord-265941-eff4le0g	112	8	,	,	,
cord-265941-eff4le0g	112	9	and	and	CC
cord-265941-eff4le0g	112	10	not	not	RB
cord-265941-eff4le0g	112	11	its	-PRON-	PRP$
cord-265941-eff4le0g	112	12	N	n	CD
cord-265941-eff4le0g	112	13	-	-	HYPH
cord-265941-eff4le0g	112	14	terminal	terminal	JJ
cord-265941-eff4le0g	112	15	RHIM	RHIM	NNP
cord-265941-eff4le0g	112	16	-	-	HYPH
cord-265941-eff4le0g	112	17	like	like	JJ
cord-265941-eff4le0g	112	18	domain	domain	NN
cord-265941-eff4le0g	112	19	,	,	,
cord-265941-eff4le0g	112	20	also	also	RB
cord-265941-eff4le0g	112	21	binds	bind	VBZ
cord-265941-eff4le0g	112	22	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	112	23	and	and	CC
cord-265941-eff4le0g	112	24	prevents	prevent	VBZ
cord-265941-eff4le0g	112	25	poly(I	poly(I	NNS
cord-265941-eff4le0g	112	26	:	:	:
cord-265941-eff4le0g	112	27	C)-induced	c)-induced	JJ
cord-265941-eff4le0g	112	28	apoptosis	apoptosis	NN
cord-265941-eff4le0g	112	29	in	in	IN
cord-265941-eff4le0g	112	30	human	human	JJ
cord-265941-eff4le0g	112	31	cells	cell	NNS
cord-265941-eff4le0g	112	32	[	[	-LRB-
cord-265941-eff4le0g	112	33	73	73	CD
cord-265941-eff4le0g	112	34	]	]	-RRB-
cord-265941-eff4le0g	112	35	.	.	.
cord-265941-eff4le0g	113	1	Moreover	moreover	RB
cord-265941-eff4le0g	113	2	,	,	,
cord-265941-eff4le0g	113	3	ICP6	ICP6	NNP
cord-265941-eff4le0g	113	4	and	and	CC
cord-265941-eff4le0g	113	5	ICP10	ICP10	NNP
cord-265941-eff4le0g	113	6	can	can	MD
cord-265941-eff4le0g	113	7	disrupt	disrupt	VB
cord-265941-eff4le0g	113	8	the	the	DT
cord-265941-eff4le0g	113	9	RHIM	RHIM	NNP
cord-265941-eff4le0g	113	10	-	-	HYPH
cord-265941-eff4le0g	113	11	dependent	dependent	JJ
cord-265941-eff4le0g	113	12	interaction	interaction	NN
cord-265941-eff4le0g	113	13	between	between	IN
cord-265941-eff4le0g	113	14	TRIF	TRIF	NNP
cord-265941-eff4le0g	113	15	and	and	CC
cord-265941-eff4le0g	113	16	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	113	17	,	,	,
cord-265941-eff4le0g	113	18	which	which	WDT
cord-265941-eff4le0g	113	19	may	may	MD
cord-265941-eff4le0g	113	20	contribute	contribute	VB
cord-265941-eff4le0g	113	21	to	to	IN
cord-265941-eff4le0g	113	22	the	the	DT
cord-265941-eff4le0g	113	23	disabling	disabling	NN
cord-265941-eff4le0g	113	24	of	of	IN
cord-265941-eff4le0g	113	25	apoptosis	apoptosis	NN
cord-265941-eff4le0g	113	26	.	.	.
cord-265941-eff4le0g	114	1	Although	although	IN
cord-265941-eff4le0g	114	2	the	the	DT
cord-265941-eff4le0g	114	3	role	role	NN
cord-265941-eff4le0g	114	4	of	of	IN
cord-265941-eff4le0g	114	5	this	this	DT
cord-265941-eff4le0g	114	6	cell	cell	NN
cord-265941-eff4le0g	114	7	death	death	NN
cord-265941-eff4le0g	114	8	inhibition	inhibition	NN
cord-265941-eff4le0g	114	9	in	in	IN
cord-265941-eff4le0g	114	10	viral	viral	JJ
cord-265941-eff4le0g	114	11	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	114	12	has	have	VBZ
cord-265941-eff4le0g	114	13	not	not	RB
cord-265941-eff4le0g	114	14	been	be	VBN
cord-265941-eff4le0g	114	15	examined	examine	VBN
cord-265941-eff4le0g	114	16	,	,	,
cord-265941-eff4le0g	114	17	it	-PRON-	PRP
cord-265941-eff4le0g	114	18	appears	appear	VBZ
cord-265941-eff4le0g	114	19	HSV	HSV	NNP
cord-265941-eff4le0g	114	20	has	have	VBZ
cord-265941-eff4le0g	114	21	a	a	DT
cord-265941-eff4le0g	114	22	strategy	strategy	NN
cord-265941-eff4le0g	114	23	for	for	IN
cord-265941-eff4le0g	114	24	managing	manage	VBG
cord-265941-eff4le0g	114	25	dsRNA	dsrna	JJ
cord-265941-eff4le0g	114	26	mediated	mediate	VBN
cord-265941-eff4le0g	114	27	apoptosis	apoptosis	NN
cord-265941-eff4le0g	114	28	.	.	.
cord-265941-eff4le0g	115	1	Similarly	similarly	RB
cord-265941-eff4le0g	115	2	,	,	,
cord-265941-eff4le0g	115	3	initiation	initiation	NN
cord-265941-eff4le0g	115	4	of	of	IN
cord-265941-eff4le0g	115	5	IAV	IAV	NNP
cord-265941-eff4le0g	115	6	-	-	HYPH
cord-265941-eff4le0g	115	7	induced	induce	VBN
cord-265941-eff4le0g	115	8	PAN	PAN	NNP
cord-265941-eff4le0g	115	9	-	-	HYPH
cord-265941-eff4le0g	115	10	optosis	optosis	NNP
cord-265941-eff4le0g	115	11	(	(	-LRB-
cord-265941-eff4le0g	115	12	pyroptosis	pyroptosis	NNP
cord-265941-eff4le0g	115	13	,	,	,
cord-265941-eff4le0g	115	14	apoptosis	apoptosis	NN
cord-265941-eff4le0g	115	15	,	,	,
cord-265941-eff4le0g	115	16	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	115	17	)	)	-RRB-
cord-265941-eff4le0g	115	18	requires	require	VBZ
cord-265941-eff4le0g	115	19	DAI	DAI	NNP
cord-265941-eff4le0g	115	20	sensing	sensing	NN
cord-265941-eff4le0g	115	21	of	of	IN
cord-265941-eff4le0g	115	22	viral	viral	JJ
cord-265941-eff4le0g	115	23	RNA	RNA	NNP
cord-265941-eff4le0g	115	24	through	through	IN
cord-265941-eff4le0g	115	25	its	-PRON-	PRP$
cord-265941-eff4le0g	115	26	second	second	JJ
cord-265941-eff4le0g	115	27	Zα	Zα	NNP
cord-265941-eff4le0g	115	28	domain	domain	NN
cord-265941-eff4le0g	115	29	[	[	-LRB-
cord-265941-eff4le0g	115	30	74	74	CD
cord-265941-eff4le0g	115	31	,	,	,
cord-265941-eff4le0g	115	32	75	75	CD
cord-265941-eff4le0g	115	33	]	]	-RRB-
cord-265941-eff4le0g	115	34	,	,	,
cord-265941-eff4le0g	115	35	though	though	IN
cord-265941-eff4le0g	115	36	DAI	DAI	NNP
cord-265941-eff4le0g	115	37	is	be	VBZ
cord-265941-eff4le0g	115	38	recently	recently	RB
cord-265941-eff4le0g	115	39	reported	report	VBN
cord-265941-eff4le0g	115	40	to	to	TO
cord-265941-eff4le0g	115	41	also	also	RB
cord-265941-eff4le0g	115	42	detect	detect	VB
cord-265941-eff4le0g	115	43	IAV	IAV	NNP
cord-265941-eff4le0g	115	44	nucleoprotein	nucleoprotein	NNP
cord-265941-eff4le0g	115	45	(	(	-LRB-
cord-265941-eff4le0g	115	46	NP	NP	NNP
cord-265941-eff4le0g	115	47	)	)	-RRB-
cord-265941-eff4le0g	115	48	and	and	CC
cord-265941-eff4le0g	115	49	polymerase	polymerase	NN
cord-265941-eff4le0g	115	50	subunit	subunit	NN
cord-265941-eff4le0g	115	51	(	(	-LRB-
cord-265941-eff4le0g	115	52	PB1	PB1	NNP
cord-265941-eff4le0g	115	53	)	)	-RRB-
cord-265941-eff4le0g	115	54	,	,	,
cord-265941-eff4le0g	115	55	as	as	IN
cord-265941-eff4le0g	115	56	a	a	DT
cord-265941-eff4le0g	115	57	collective	collective	JJ
cord-265941-eff4le0g	115	58	unit	unit	NN
cord-265941-eff4le0g	115	59	of	of	IN
cord-265941-eff4le0g	115	60	viral	viral	JJ
cord-265941-eff4le0g	115	61	ribonucleoprotein	ribonucleoprotein	NN
cord-265941-eff4le0g	115	62	[	[	-LRB-
cord-265941-eff4le0g	115	63	76	76	CD
cord-265941-eff4le0g	115	64	,	,	,
cord-265941-eff4le0g	115	65	77	77	CD
cord-265941-eff4le0g	115	66	]	]	-RRB-
cord-265941-eff4le0g	115	67	.	.	.
cord-265941-eff4le0g	116	1	Upon	upon	IN
cord-265941-eff4le0g	116	2	stimulation	stimulation	NN
cord-265941-eff4le0g	116	3	,	,	,
cord-265941-eff4le0g	116	4	DAI	DAI	NNP
cord-265941-eff4le0g	116	5	associates	associate	NNS
cord-265941-eff4le0g	116	6	with	with	IN
cord-265941-eff4le0g	116	7	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	116	8	,	,	,
cord-265941-eff4le0g	116	9	which	which	WDT
cord-265941-eff4le0g	116	10	recruits	recruit	VBZ
cord-265941-eff4le0g	116	11	RIPK1	ripk1	JJ
cord-265941-eff4le0g	116	12	,	,	,
cord-265941-eff4le0g	116	13	FADD	FADD	NNP
cord-265941-eff4le0g	116	14	and	and	CC
cord-265941-eff4le0g	116	15	MLKL	MLKL	NNP
cord-265941-eff4le0g	116	16	to	to	TO
cord-265941-eff4le0g	116	17	form	form	VB
cord-265941-eff4le0g	116	18	a	a	DT
cord-265941-eff4le0g	116	19	"	"	``
cord-265941-eff4le0g	116	20	ripoptosome	ripoptosome	JJ
cord-265941-eff4le0g	116	21	"	"	''
cord-265941-eff4le0g	116	22	complex	complex	JJ
cord-265941-eff4le0g	116	23	[	[	-LRB-
cord-265941-eff4le0g	116	24	75	75	CD
cord-265941-eff4le0g	116	25	,	,	,
cord-265941-eff4le0g	116	26	78	78	CD
cord-265941-eff4le0g	116	27	]	]	-RRB-
cord-265941-eff4le0g	116	28	.	.	.
cord-265941-eff4le0g	117	1	Here	here	RB
cord-265941-eff4le0g	117	2	,	,	,
cord-265941-eff4le0g	117	3	the	the	DT
cord-265941-eff4le0g	117	4	apoptotic	apoptotic	JJ
cord-265941-eff4le0g	117	5	arm	arm	NN
cord-265941-eff4le0g	117	6	operates	operate	VBZ
cord-265941-eff4le0g	117	7	under	under	IN
cord-265941-eff4le0g	117	8	Fig	Fig	NNP
cord-265941-eff4le0g	117	9	.	.	.
cord-265941-eff4le0g	118	1	1	1	LS
cord-265941-eff4le0g	118	2	.	.	.
cord-265941-eff4le0g	119	1	Inflammatory	inflammatory	JJ
cord-265941-eff4le0g	119	2	pathways	pathway	NNS
cord-265941-eff4le0g	119	3	mediated	mediate	VBN
cord-265941-eff4le0g	119	4	by	by	IN
cord-265941-eff4le0g	119	5	RIPK1/3	RIPK1/3	NNP
cord-265941-eff4le0g	119	6	in	in	IN
cord-265941-eff4le0g	119	7	response	response	NN
cord-265941-eff4le0g	119	8	to	to	IN
cord-265941-eff4le0g	119	9	pathogen	pathogen	NN
cord-265941-eff4le0g	119	10	sensing	sensing	NN
cord-265941-eff4le0g	119	11	.	.	.
cord-265941-eff4le0g	120	1	Upon	upon	IN
cord-265941-eff4le0g	120	2	stimulation	stimulation	NN
cord-265941-eff4le0g	120	3	with	with	IN
cord-265941-eff4le0g	120	4	TNF	TNF	NNP
cord-265941-eff4le0g	120	5	,	,	,
cord-265941-eff4le0g	120	6	TNFR1	TNFR1	NNP
cord-265941-eff4le0g	120	7	recruits	recruit	VBZ
cord-265941-eff4le0g	120	8	TRADD	TRADD	NNP
cord-265941-eff4le0g	120	9	and	and	CC
cord-265941-eff4le0g	120	10	RIPK1	ripk1	XX
cord-265941-eff4le0g	120	11	via	via	IN
cord-265941-eff4le0g	120	12	the	the	DT
cord-265941-eff4le0g	120	13	DD	DD	NNP
cord-265941-eff4le0g	120	14	,	,	,
cord-265941-eff4le0g	120	15	then	then	RB
cord-265941-eff4le0g	120	16	subsequently	subsequently	RB
cord-265941-eff4le0g	120	17	TRAF2/5	TRAF2/5	NNP
cord-265941-eff4le0g	120	18	and	and	CC
cord-265941-eff4le0g	120	19	cIAP1/2	ciap1/2	XX
cord-265941-eff4le0g	120	20	to	to	TO
cord-265941-eff4le0g	120	21	form	form	VB
cord-265941-eff4le0g	120	22	a	a	DT
cord-265941-eff4le0g	120	23	membrane	membrane	NN
cord-265941-eff4le0g	120	24	-	-	HYPH
cord-265941-eff4le0g	120	25	bound	bind	VBN
cord-265941-eff4le0g	120	26	pro	pro	JJ
cord-265941-eff4le0g	120	27	-	-	JJ
cord-265941-eff4le0g	120	28	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	120	29	signaling	signaling	NN
cord-265941-eff4le0g	120	30	complex	complex	NN
cord-265941-eff4le0g	120	31	[	[	-LRB-
cord-265941-eff4le0g	120	32	10	10	CD
cord-265941-eff4le0g	120	33	,	,	,
cord-265941-eff4le0g	120	34	11	11	CD
cord-265941-eff4le0g	120	35	]	]	-RRB-
cord-265941-eff4le0g	120	36	.	.	.
cord-265941-eff4le0g	121	1	Ubiquitylation	Ubiquitylation	NNP
cord-265941-eff4le0g	121	2	of	of	IN
cord-265941-eff4le0g	121	3	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	121	4	by	by	IN
cord-265941-eff4le0g	121	5	cIAP1/2	cIAP1/2	NNPS
cord-265941-eff4le0g	121	6	and	and	CC
cord-265941-eff4le0g	121	7	LUBAC	LUBAC	NNP
cord-265941-eff4le0g	121	8	enables	enable	VBZ
cord-265941-eff4le0g	121	9	recruitment	recruitment	NN
cord-265941-eff4le0g	121	10	of	of	IN
cord-265941-eff4le0g	121	11	TAK1	TAK1	NNP
cord-265941-eff4le0g	121	12	and	and	CC
cord-265941-eff4le0g	121	13	the	the	DT
cord-265941-eff4le0g	121	14	IKK	IKK	NNP
cord-265941-eff4le0g	121	15	complex	complex	NN
cord-265941-eff4le0g	121	16	,	,	,
cord-265941-eff4le0g	121	17	which	which	WDT
cord-265941-eff4le0g	121	18	promotes	promote	VBZ
cord-265941-eff4le0g	121	19	activation	activation	NN
cord-265941-eff4le0g	121	20	of	of	IN
cord-265941-eff4le0g	121	21	MAPK	MAPK	NNP
cord-265941-eff4le0g	121	22	and	and	CC
cord-265941-eff4le0g	121	23	canonical	canonical	JJ
cord-265941-eff4le0g	121	24	NF	nf	NN
cord-265941-eff4le0g	121	25	-	-	HYPH
cord-265941-eff4le0g	121	26	κB	κB	NNP
cord-265941-eff4le0g	121	27	signaling	signal	VBG
cord-265941-eff4le0g	121	28	[	[	-LRB-
cord-265941-eff4le0g	121	29	12	12	CD
cord-265941-eff4le0g	121	30	]	]	-RRB-
cord-265941-eff4le0g	122	1	[	[	-LRB-
cord-265941-eff4le0g	122	2	13	13	CD
cord-265941-eff4le0g	122	3	]	]	-RRB-
cord-265941-eff4le0g	122	4	[	[	-LRB-
cord-265941-eff4le0g	122	5	14	14	CD
cord-265941-eff4le0g	122	6	]	]	-RRB-
cord-265941-eff4le0g	122	7	[	[	-LRB-
cord-265941-eff4le0g	122	8	15	15	CD
cord-265941-eff4le0g	122	9	]	]	-RRB-
cord-265941-eff4le0g	122	10	.	.	.
cord-265941-eff4le0g	123	1	Ligation	ligation	NN
cord-265941-eff4le0g	123	2	of	of	IN
cord-265941-eff4le0g	123	3	TLR3/4	TLR3/4	NNP
cord-265941-eff4le0g	123	4	reinforces	reinforce	VBZ
cord-265941-eff4le0g	123	5	these	these	DT
cord-265941-eff4le0g	123	6	pathways	pathway	NNS
cord-265941-eff4le0g	123	7	through	through	IN
cord-265941-eff4le0g	123	8	RHIM	RHIM	NNP
cord-265941-eff4le0g	123	9	-	-	HYPH
cord-265941-eff4le0g	123	10	mediated	mediate	VBN
cord-265941-eff4le0g	123	11	interactions	interaction	NNS
cord-265941-eff4le0g	123	12	between	between	IN
cord-265941-eff4le0g	123	13	TRIF	TRIF	NNP
cord-265941-eff4le0g	123	14	and	and	CC
cord-265941-eff4le0g	123	15	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	123	16	,	,	,
cord-265941-eff4le0g	123	17	with	with	IN
cord-265941-eff4le0g	123	18	subsequent	subsequent	JJ
cord-265941-eff4le0g	123	19	RIPK1	ripk1	JJ
cord-265941-eff4le0g	123	20	ubiquitylation	ubiquitylation	NN
cord-265941-eff4le0g	123	21	continuing	continue	VBG
cord-265941-eff4le0g	123	22	to	to	TO
cord-265941-eff4le0g	123	23	drive	drive	VB
cord-265941-eff4le0g	123	24	NF	NF	NNP
cord-265941-eff4le0g	123	25	-	-	HYPH
cord-265941-eff4le0g	123	26	κB	κb	CD
cord-265941-eff4le0g	123	27	activation	activation	NN
cord-265941-eff4le0g	123	28	[	[	-LRB-
cord-265941-eff4le0g	123	29	7	7	CD
cord-265941-eff4le0g	123	30	,	,	,
cord-265941-eff4le0g	123	31	16	16	CD
cord-265941-eff4le0g	123	32	]	]	-RRB-
cord-265941-eff4le0g	123	33	.	.	.
cord-265941-eff4le0g	124	1	TLR4-TRIF	tlr4-trif	JJ
cord-265941-eff4le0g	124	2	interactions	interaction	NNS
cord-265941-eff4le0g	124	3	can	can	MD
cord-265941-eff4le0g	124	4	also	also	RB
cord-265941-eff4le0g	124	5	induce	induce	VB
cord-265941-eff4le0g	124	6	Type	type	NN
cord-265941-eff4le0g	124	7	I	-PRON-	PRP
cord-265941-eff4le0g	124	8	IFN	IFN	NNP
cord-265941-eff4le0g	124	9	signaling	signal	VBG
cord-265941-eff4le0g	124	10	via	via	IN
cord-265941-eff4le0g	124	11	recruitment	recruitment	NN
cord-265941-eff4le0g	124	12	of	of	IN
cord-265941-eff4le0g	124	13	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	124	14	and	and	CC
cord-265941-eff4le0g	124	15	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	124	16	,	,	,
cord-265941-eff4le0g	124	17	which	which	WDT
cord-265941-eff4le0g	124	18	activates	activate	VBZ
cord-265941-eff4le0g	124	19	TBK1	TBK1	NNP
cord-265941-eff4le0g	124	20	and	and	CC
cord-265941-eff4le0g	124	21	IKKε	IKKε	NNS
cord-265941-eff4le0g	124	22	to	to	TO
cord-265941-eff4le0g	124	23	promote	promote	VB
cord-265941-eff4le0g	124	24	nuclear	nuclear	JJ
cord-265941-eff4le0g	124	25	translocation	translocation	NN
cord-265941-eff4le0g	124	26	of	of	IN
cord-265941-eff4le0g	124	27	IRF3	IRF3	NNP
cord-265941-eff4le0g	124	28	[	[	-LRB-
cord-265941-eff4le0g	124	29	17	17	CD
cord-265941-eff4le0g	124	30	]	]	-RRB-
cord-265941-eff4le0g	124	31	.	.	.
cord-265941-eff4le0g	125	1	In	in	IN
cord-265941-eff4le0g	125	2	response	response	NN
cord-265941-eff4le0g	125	3	to	to	IN
cord-265941-eff4le0g	125	4	dsRNA	dsrna	NN
cord-265941-eff4le0g	125	5	sensing	sensing	NN
cord-265941-eff4le0g	125	6	by	by	IN
cord-265941-eff4le0g	125	7	cytosolic	cytosolic	JJ
cord-265941-eff4le0g	125	8	RIG	rig	NN
cord-265941-eff4le0g	125	9	-	-	:
cord-265941-eff4le0g	125	10	I	I	NNP
cord-265941-eff4le0g	125	11	or	or	CC
cord-265941-eff4le0g	125	12	MDA5	MDA5	NNP
cord-265941-eff4le0g	125	13	,	,	,
cord-265941-eff4le0g	125	14	MAVS	MAVS	NNP
cord-265941-eff4le0g	125	15	-	-	HYPH
cord-265941-eff4le0g	125	16	RIPK1	ripk1	NN
cord-265941-eff4le0g	125	17	interactions	interaction	NNS
cord-265941-eff4le0g	125	18	additionally	additionally	RB
cord-265941-eff4le0g	125	19	drive	drive	VBP
cord-265941-eff4le0g	125	20	IRF3	IRF3	NNP
cord-265941-eff4le0g	125	21	and	and	CC
cord-265941-eff4le0g	125	22	NF	NF	NNP
cord-265941-eff4le0g	125	23	-	-	HYPH
cord-265941-eff4le0g	125	24	ĸB	ĸb	NN
cord-265941-eff4le0g	125	25	transcription	transcription	NN
cord-265941-eff4le0g	125	26	pathways	pathway	NNS
cord-265941-eff4le0g	125	27	[	[	-LRB-
cord-265941-eff4le0g	125	28	18	18	CD
cord-265941-eff4le0g	125	29	]	]	-RRB-
cord-265941-eff4le0g	125	30	[	[	-LRB-
cord-265941-eff4le0g	125	31	19	19	CD
cord-265941-eff4le0g	125	32	]	]	-RRB-
cord-265941-eff4le0g	125	33	[	[	-LRB-
cord-265941-eff4le0g	125	34	20	20	CD
cord-265941-eff4le0g	125	35	]	]	-RRB-
cord-265941-eff4le0g	125	36	.	.	.
cord-265941-eff4le0g	126	1	Finally	finally	RB
cord-265941-eff4le0g	126	2	,	,	,
cord-265941-eff4le0g	126	3	cytosolic	cytosolic	JJ
cord-265941-eff4le0g	126	4	dsDNA	dsdna	RB
cord-265941-eff4le0g	127	1	sensing	sensing	NN
cord-265941-eff4le0g	127	2	by	by	IN
cord-265941-eff4le0g	127	3	DAI	DAI	NNP
cord-265941-eff4le0g	127	4	/	/	SYM
cord-265941-eff4le0g	127	5	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	127	6	promotes	promote	VBZ
cord-265941-eff4le0g	127	7	NF	nf	NN
cord-265941-eff4le0g	127	8	-	-	HYPH
cord-265941-eff4le0g	127	9	ĸB	ĸb	NN
cord-265941-eff4le0g	127	10	induction	induction	NN
cord-265941-eff4le0g	127	11	via	via	IN
cord-265941-eff4le0g	127	12	RHIM	RHIM	NNP
cord-265941-eff4le0g	127	13	-	-	HYPH
cord-265941-eff4le0g	127	14	mediated	mediate	VBN
cord-265941-eff4le0g	127	15	recruitment	recruitment	NN
cord-265941-eff4le0g	127	16	of	of	IN
cord-265941-eff4le0g	127	17	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	127	18	,	,	,
cord-265941-eff4le0g	127	19	with	with	IN
cord-265941-eff4le0g	127	20	RIPK3	ripk3	NN
cord-265941-eff4le0g	127	21	kinase	kinase	NN
cord-265941-eff4le0g	127	22	activity	activity	NN
cord-265941-eff4le0g	127	23	also	also	RB
cord-265941-eff4le0g	127	24	required	require	VBD
cord-265941-eff4le0g	127	25	for	for	IN
cord-265941-eff4le0g	127	26	synergistic	synergistic	JJ
cord-265941-eff4le0g	127	27	activation	activation	NN
cord-265941-eff4le0g	127	28	[	[	-LRB-
cord-265941-eff4le0g	127	29	21	21	CD
cord-265941-eff4le0g	127	30	,	,	,
cord-265941-eff4le0g	127	31	22	22	CD
cord-265941-eff4le0g	127	32	]	]	-RRB-
cord-265941-eff4le0g	127	33	.	.	.
cord-265941-eff4le0g	128	1	Virulence	virulence	NN
cord-265941-eff4le0g	128	2	factors	factor	NNS
cord-265941-eff4le0g	128	3	that	that	WDT
cord-265941-eff4le0g	128	4	interact	interact	VBP
cord-265941-eff4le0g	128	5	with	with	IN
cord-265941-eff4le0g	128	6	these	these	DT
cord-265941-eff4le0g	128	7	pathways	pathway	NNS
cord-265941-eff4le0g	128	8	are	be	VBP
cord-265941-eff4le0g	128	9	indicated	indicate	VBN
cord-265941-eff4le0g	128	10	,	,	,
cord-265941-eff4le0g	128	11	and	and	CC
cord-265941-eff4le0g	128	12	have	have	VBP
cord-265941-eff4le0g	128	13	been	be	VBN
cord-265941-eff4le0g	128	14	discussed	discuss	VBN
cord-265941-eff4le0g	128	15	in	in	IN
cord-265941-eff4le0g	128	16	text	text	NN
cord-265941-eff4le0g	128	17	the	the	DT
cord-265941-eff4le0g	128	18	main	main	JJ
cord-265941-eff4le0g	128	19	body	body	NN
cord-265941-eff4le0g	128	20	of	of	IN
cord-265941-eff4le0g	128	21	text	text	NN
cord-265941-eff4le0g	128	22	.	.	.
cord-265941-eff4le0g	129	1	a	a	DT
cord-265941-eff4le0g	129	2	RIPK1-FADD	RIPK1-FADD	NNP
cord-265941-eff4le0g	129	3	-	-	HYPH
cord-265941-eff4le0g	129	4	caspase-8	caspase-8	JJ
cord-265941-eff4le0g	129	5	axis	axis	NN
cord-265941-eff4le0g	129	6	,	,	,
cord-265941-eff4le0g	129	7	in	in	IN
cord-265941-eff4le0g	129	8	a	a	DT
cord-265941-eff4le0g	129	9	manner	manner	NN
cord-265941-eff4le0g	129	10	independent	independent	NN
cord-265941-eff4le0g	129	11	of	of	IN
cord-265941-eff4le0g	129	12	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	130	1	kinase	kinase	NN
cord-265941-eff4le0g	130	2	activity	activity	NN
cord-265941-eff4le0g	130	3	[	[	-LRB-
cord-265941-eff4le0g	130	4	78	78	CD
cord-265941-eff4le0g	130	5	]	]	-RRB-
cord-265941-eff4le0g	130	6	.	.	.
cord-265941-eff4le0g	131	1	Neither	neither	DT
cord-265941-eff4le0g	131	2	caspase	caspase	NN
cord-265941-eff4le0g	131	3	inhibition	inhibition	NN
cord-265941-eff4le0g	131	4	through	through	IN
cord-265941-eff4le0g	131	5	z	z	NNP
cord-265941-eff4le0g	131	6	-	-	HYPH
cord-265941-eff4le0g	131	7	VAD	VAD	NNP
cord-265941-eff4le0g	131	8	nor	nor	CC
cord-265941-eff4le0g	131	9	FADD	FADD	NNP
cord-265941-eff4le0g	131	10	deletion	deletion	NN
cord-265941-eff4le0g	131	11	in	in	IN
cord-265941-eff4le0g	131	12	mouse	mouse	NN
cord-265941-eff4le0g	131	13	fibroblasts	fibroblast	NNS
cord-265941-eff4le0g	131	14	rescues	rescue	VBZ
cord-265941-eff4le0g	131	15	cell	cell	NN
cord-265941-eff4le0g	131	16	viability	viability	NN
cord-265941-eff4le0g	131	17	,	,	,
cord-265941-eff4le0g	131	18	but	but	CC
cord-265941-eff4le0g	131	19	pre	pre	JJ
cord-265941-eff4le0g	131	20	-	-	NN
cord-265941-eff4le0g	131	21	treatment	treatment	NN
cord-265941-eff4le0g	131	22	of	of	IN
cord-265941-eff4le0g	131	23	these	these	DT
cord-265941-eff4le0g	131	24	cells	cell	NNS
cord-265941-eff4le0g	131	25	with	with	IN
cord-265941-eff4le0g	131	26	RIPK3	ripk3	NN
cord-265941-eff4le0g	131	27	kinase	kinase	NN
cord-265941-eff4le0g	131	28	inhibitors	inhibitor	NNS
cord-265941-eff4le0g	131	29	grants	grant	VBZ
cord-265941-eff4le0g	131	30	significant	significant	JJ
cord-265941-eff4le0g	131	31	protection	protection	NN
cord-265941-eff4le0g	131	32	,	,	,
cord-265941-eff4le0g	131	33	thus	thus	RB
cord-265941-eff4le0g	131	34	highlighting	highlight	VBG
cord-265941-eff4le0g	131	35	the	the	DT
cord-265941-eff4le0g	131	36	importance	importance	NN
cord-265941-eff4le0g	131	37	of	of	IN
cord-265941-eff4le0g	131	38	RIPK3	ripk3	NN
cord-265941-eff4le0g	131	39	in	in	IN
cord-265941-eff4le0g	131	40	regulating	regulate	VBG
cord-265941-eff4le0g	131	41	the	the	DT
cord-265941-eff4le0g	131	42	parallel	parallel	JJ
cord-265941-eff4le0g	131	43	cell	cell	NN
cord-265941-eff4le0g	131	44	death	death	NN
cord-265941-eff4le0g	131	45	pathways	pathway	NNS
cord-265941-eff4le0g	131	46	.	.	.
cord-265941-eff4le0g	132	1	Surprisingly	surprisingly	RB
cord-265941-eff4le0g	132	2	,	,	,
cord-265941-eff4le0g	132	3	DAI	DAI	NNP
cord-265941-eff4le0g	132	4	also	also	RB
cord-265941-eff4le0g	132	5	triggers	trigger	VBZ
cord-265941-eff4le0g	132	6	RIPK3-independent	ripk3-independent	CD
cord-265941-eff4le0g	132	7	apoptosis	apoptosis	NN
cord-265941-eff4le0g	132	8	,	,	,
cord-265941-eff4le0g	132	9	where	where	WRB
cord-265941-eff4le0g	132	10	DAI	DAI	NNP
cord-265941-eff4le0g	132	11	engages	engage	VBZ
cord-265941-eff4le0g	132	12	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	132	13	directly	directly	RB
cord-265941-eff4le0g	132	14	to	to	TO
cord-265941-eff4le0g	132	15	recruit	recruit	VB
cord-265941-eff4le0g	132	16	FADD	FADD	NNP
cord-265941-eff4le0g	132	17	and	and	CC
cord-265941-eff4le0g	132	18	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	132	19	,	,	,
cord-265941-eff4le0g	132	20	which	which	WDT
cord-265941-eff4le0g	132	21	deploys	deploy	VBZ
cord-265941-eff4le0g	132	22	an	an	DT
cord-265941-eff4le0g	132	23	alternative	alternative	NN
cord-265941-eff4le0g	132	24	,	,	,
cord-265941-eff4le0g	132	25	delayed	delay	VBN
cord-265941-eff4le0g	132	26	apoptotic	apoptotic	JJ
cord-265941-eff4le0g	132	27	cell	cell	NN
cord-265941-eff4le0g	132	28	death	death	NN
cord-265941-eff4le0g	132	29	[	[	-LRB-
cord-265941-eff4le0g	132	30	75	75	CD
cord-265941-eff4le0g	132	31	,	,	,
cord-265941-eff4le0g	132	32	78	78	CD
cord-265941-eff4le0g	132	33	]	]	-RRB-
cord-265941-eff4le0g	132	34	.	.	.
cord-265941-eff4le0g	133	1	As	as	IN
cord-265941-eff4le0g	133	2	inhibition	inhibition	NN
cord-265941-eff4le0g	133	3	of	of	IN
cord-265941-eff4le0g	133	4	necroptosis	necroptosis	NN
cord-265941-eff4le0g	133	5	does	do	VBZ
cord-265941-eff4le0g	133	6	not	not	RB
cord-265941-eff4le0g	133	7	affect	affect	VB
cord-265941-eff4le0g	133	8	IAV	IAV	NNP
cord-265941-eff4le0g	133	9	control	control	NN
cord-265941-eff4le0g	133	10	,	,	,
cord-265941-eff4le0g	133	11	while	while	IN
cord-265941-eff4le0g	133	12	Mlkl-/-Fadd-/-mice	Mlkl-/-Fadd-/-mice	NNP
cord-265941-eff4le0g	133	13	exhibit	exhibit	NN
cord-265941-eff4le0g	133	14	marked	mark	VBN
cord-265941-eff4le0g	133	15	susceptibility	susceptibility	NN
cord-265941-eff4le0g	133	16	to	to	IN
cord-265941-eff4le0g	133	17	IAV	iav	NN
cord-265941-eff4le0g	133	18	-	-	HYPH
cord-265941-eff4le0g	133	19	induced	induce	VBN
cord-265941-eff4le0g	133	20	lethality	lethality	NN
cord-265941-eff4le0g	133	21	[	[	-LRB-
cord-265941-eff4le0g	133	22	78	78	CD
cord-265941-eff4le0g	133	23	]	]	-RRB-
cord-265941-eff4le0g	133	24	,	,	,
cord-265941-eff4le0g	133	25	it	-PRON-	PRP
cord-265941-eff4le0g	133	26	signifies	signify	VBZ
cord-265941-eff4le0g	133	27	that	that	IN
cord-265941-eff4le0g	133	28	RIPK1/3-mediated	ripk1/3-mediate	VBN
cord-265941-eff4le0g	133	29	apoptosis	apoptosis	NN
cord-265941-eff4le0g	133	30	is	be	VBZ
cord-265941-eff4le0g	133	31	a	a	DT
cord-265941-eff4le0g	133	32	major	major	JJ
cord-265941-eff4le0g	133	33	form	form	NN
cord-265941-eff4le0g	133	34	of	of	IN
cord-265941-eff4le0g	133	35	host	host	NN
cord-265941-eff4le0g	133	36	protection	protection	NN
cord-265941-eff4le0g	133	37	against	against	IN
cord-265941-eff4le0g	133	38	IAV	IAV	NNP
cord-265941-eff4le0g	133	39	infection	infection	NN
cord-265941-eff4le0g	133	40	.	.	.
cord-265941-eff4le0g	134	1	In	in	IN
cord-265941-eff4le0g	134	2	response	response	NN
cord-265941-eff4le0g	134	3	to	to	IN
cord-265941-eff4le0g	134	4	YopJ	YopJ	NNP
cord-265941-eff4le0g	134	5	-	-	HYPH
cord-265941-eff4le0g	134	6	mediated	mediate	VBN
cord-265941-eff4le0g	134	7	abrogation	abrogation	NN
cord-265941-eff4le0g	134	8	of	of	IN
cord-265941-eff4le0g	134	9	inflammation	inflammation	NN
cord-265941-eff4le0g	134	10	during	during	IN
cord-265941-eff4le0g	134	11	Yersinia	Yersinia	NNP
cord-265941-eff4le0g	134	12	infection	infection	NN
cord-265941-eff4le0g	134	13	[	[	-LRB-
cord-265941-eff4le0g	134	14	40	40	CD
cord-265941-eff4le0g	134	15	]	]	-RRB-
cord-265941-eff4le0g	134	16	,	,	,
cord-265941-eff4le0g	134	17	infected	infected	JJ
cord-265941-eff4le0g	134	18	macrophages	macrophage	NNS
cord-265941-eff4le0g	134	19	engage	engage	VBP
cord-265941-eff4le0g	134	20	TLR4	TLR4	NNP
cord-265941-eff4le0g	134	21	/	/	SYM
cord-265941-eff4le0g	134	22	TRIF	TRIF	NNP
cord-265941-eff4le0g	134	23	and	and	CC
cord-265941-eff4le0g	134	24	TNFR1	TNFR1	NNP
cord-265941-eff4le0g	135	1	to	to	TO
cord-265941-eff4le0g	135	2	induce	induce	VB
cord-265941-eff4le0g	135	3	apoptotic	apoptotic	JJ
cord-265941-eff4le0g	135	4	cell	cell	NN
cord-265941-eff4le0g	135	5	death	death	NN
cord-265941-eff4le0g	135	6	[	[	-LRB-
cord-265941-eff4le0g	135	7	39	39	CD
cord-265941-eff4le0g	135	8	]	]	-RRB-
cord-265941-eff4le0g	135	9	.	.	.
cord-265941-eff4le0g	136	1	Both	both	DT
cord-265941-eff4le0g	136	2	cell	cell	NN
cord-265941-eff4le0g	136	3	death	death	NN
cord-265941-eff4le0g	136	4	pathways	pathway	NNS
cord-265941-eff4le0g	136	5	occur	occur	VBP
cord-265941-eff4le0g	136	6	in	in	IN
cord-265941-eff4le0g	136	7	a	a	DT
cord-265941-eff4le0g	136	8	non	non	JJ
cord-265941-eff4le0g	136	9	-	-	JJ
cord-265941-eff4le0g	136	10	redundant	redundant	JJ
cord-265941-eff4le0g	136	11	manner	manner	NN
cord-265941-eff4le0g	136	12	and	and	CC
cord-265941-eff4le0g	136	13	rely	rely	VB
cord-265941-eff4le0g	136	14	on	on	IN
cord-265941-eff4le0g	136	15	RIPK1-mediated	RIPK1-mediated	NNP
cord-265941-eff4le0g	136	16	activation	activation	NN
cord-265941-eff4le0g	136	17	of	of	IN
cord-265941-eff4le0g	136	18	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	136	19	for	for	IN
cord-265941-eff4le0g	136	20	downstream	downstream	JJ
cord-265941-eff4le0g	136	21	signaling	signal	VBG
cord-265941-eff4le0g	136	22	[	[	-LRB-
cord-265941-eff4le0g	136	23	39	39	CD
cord-265941-eff4le0g	136	24	,	,	,
cord-265941-eff4le0g	136	25	79	79	CD
cord-265941-eff4le0g	136	26	]	]	-RRB-
cord-265941-eff4le0g	136	27	.	.	.
cord-265941-eff4le0g	137	1	The	the	DT
cord-265941-eff4le0g	137	2	RIPK1-dependent	RIPK1-dependent	NNP
cord-265941-eff4le0g	137	3	apoptosis	apoptosis	NN
cord-265941-eff4le0g	137	4	provides	provide	VBZ
cord-265941-eff4le0g	137	5	a	a	DT
cord-265941-eff4le0g	137	6	cell	cell	NN
cord-265941-eff4le0g	137	7	-	-	HYPH
cord-265941-eff4le0g	137	8	extrinsic	extrinsic	JJ
cord-265941-eff4le0g	137	9	signal	signal	NN
cord-265941-eff4le0g	137	10	required	require	VBN
cord-265941-eff4le0g	137	11	for	for	IN
cord-265941-eff4le0g	137	12	Programmed	programmed	JJ
cord-265941-eff4le0g	137	13	cell	cell	NN
cord-265941-eff4le0g	137	14	death	death	NN
cord-265941-eff4le0g	137	15	pathways	pathway	NNS
cord-265941-eff4le0g	137	16	regulated	regulate	VBN
cord-265941-eff4le0g	137	17	by	by	IN
cord-265941-eff4le0g	137	18	RIPK1/3	RIPK1/3	NNP
cord-265941-eff4le0g	137	19	.	.	.
cord-265941-eff4le0g	138	1	Following	follow	VBG
cord-265941-eff4le0g	138	2	the	the	DT
cord-265941-eff4le0g	138	3	TNFR1-mediated	TNFR1-mediated	NNP
cord-265941-eff4le0g	138	4	assembly	assembly	NN
cord-265941-eff4le0g	138	5	of	of	IN
cord-265941-eff4le0g	138	6	pro	pro	JJ
cord-265941-eff4le0g	138	7	-	-	JJ
cord-265941-eff4le0g	138	8	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	138	9	complex	complex	NN
cord-265941-eff4le0g	139	1	I	-PRON-	PRP
cord-265941-eff4le0g	139	2	,	,	,
cord-265941-eff4le0g	139	3	deubiquitinases	deubiquitinase	NNS
cord-265941-eff4le0g	139	4	(	(	-LRB-
cord-265941-eff4le0g	139	5	CYLD	CYLD	NNP
cord-265941-eff4le0g	139	6	or	or	CC
cord-265941-eff4le0g	139	7	A20	A20	NNP
cord-265941-eff4le0g	139	8	)	)	-RRB-
cord-265941-eff4le0g	139	9	remove	remove	VBP
cord-265941-eff4le0g	139	10	polyubiquitin	polyubiquitin	NNS
cord-265941-eff4le0g	139	11	chains	chain	NNS
cord-265941-eff4le0g	139	12	from	from	IN
cord-265941-eff4le0g	139	13	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	139	14	to	to	TO
cord-265941-eff4le0g	139	15	terminate	terminate	VB
cord-265941-eff4le0g	139	16	inflammation	inflammation	NN
cord-265941-eff4le0g	139	17	and	and	CC
cord-265941-eff4le0g	139	18	enable	enable	VB
cord-265941-eff4le0g	139	19	downstream	downstream	JJ
cord-265941-eff4le0g	139	20	death	death	NN
cord-265941-eff4le0g	139	21	signaling	signal	VBG
cord-265941-eff4le0g	139	22	[	[	-LRB-
cord-265941-eff4le0g	139	23	50	50	CD
cord-265941-eff4le0g	139	24	,	,	,
cord-265941-eff4le0g	139	25	51	51	CD
cord-265941-eff4le0g	139	26	]	]	-RRB-
cord-265941-eff4le0g	139	27	.	.	.
cord-265941-eff4le0g	140	1	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	141	1	(	(	-LRB-
cord-265941-eff4le0g	141	2	with	with	IN
cord-265941-eff4le0g	141	3	RIPK3	ripk3	NN
cord-265941-eff4le0g	141	4	)	)	-RRB-
cord-265941-eff4le0g	141	5	interacts	interact	VBZ
cord-265941-eff4le0g	141	6	with	with	IN
cord-265941-eff4le0g	141	7	FADD	FADD	NNP
cord-265941-eff4le0g	141	8	and	and	CC
cord-265941-eff4le0g	141	9	pro	pro	NNP
cord-265941-eff4le0g	141	10	-	-	JJ
cord-265941-eff4le0g	141	11	caspase-8	caspase-8	JJ
cord-265941-eff4le0g	141	12	to	to	TO
cord-265941-eff4le0g	141	13	form	form	VB
cord-265941-eff4le0g	141	14	complex	complex	JJ
cord-265941-eff4le0g	141	15	IIb	iib	NN
cord-265941-eff4le0g	141	16	(	(	-LRB-
cord-265941-eff4le0g	141	17	ripoptosome	ripoptosome	NNP
cord-265941-eff4le0g	141	18	)	)	-RRB-
cord-265941-eff4le0g	141	19	[	[	-LRB-
cord-265941-eff4le0g	141	20	52	52	CD
cord-265941-eff4le0g	141	21	,	,	,
cord-265941-eff4le0g	141	22	53	53	CD
cord-265941-eff4le0g	141	23	]	]	-RRB-
cord-265941-eff4le0g	141	24	,	,	,
cord-265941-eff4le0g	141	25	and	and	CC
cord-265941-eff4le0g	141	26	can	can	MD
cord-265941-eff4le0g	141	27	initiate	initiate	VB
cord-265941-eff4le0g	141	28	extrinsic	extrinsic	JJ
cord-265941-eff4le0g	141	29	apoptosis	apoptosis	NN
cord-265941-eff4le0g	141	30	[	[	-LRB-
cord-265941-eff4le0g	141	31	54	54	CD
cord-265941-eff4le0g	141	32	,	,	,
cord-265941-eff4le0g	141	33	55	55	CD
cord-265941-eff4le0g	141	34	]	]	-RRB-
cord-265941-eff4le0g	141	35	.	.	.
cord-265941-eff4le0g	142	1	Active	Active	NNP
cord-265941-eff4le0g	142	2	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	142	3	facilitates	facilitate	VBZ
cord-265941-eff4le0g	142	4	repression	repression	NN
cord-265941-eff4le0g	142	5	of	of	IN
cord-265941-eff4le0g	142	6	necroptosis	necroptosis	NN
cord-265941-eff4le0g	142	7	and	and	CC
cord-265941-eff4le0g	142	8	NF	NF	NNP
cord-265941-eff4le0g	142	9	-	-	HYPH
cord-265941-eff4le0g	142	10	ĸB	ĸB	NNP
cord-265941-eff4le0g	142	11	signaling	signaling	NN
cord-265941-eff4le0g	142	12	by	by	IN
cord-265941-eff4le0g	142	13	cleaving	cleave	VBG
cord-265941-eff4le0g	142	14	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	142	15	and	and	CC
cord-265941-eff4le0g	142	16	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	143	1	[	[	-LRB-
cord-265941-eff4le0g	143	2	56	56	CD
cord-265941-eff4le0g	143	3	]	]	-RRB-
cord-265941-eff4le0g	143	4	[	[	-LRB-
cord-265941-eff4le0g	143	5	57	57	CD
cord-265941-eff4le0g	143	6	]	]	-RRB-
cord-265941-eff4le0g	143	7	[	[	-LRB-
cord-265941-eff4le0g	143	8	58	58	CD
cord-265941-eff4le0g	143	9	]	]	-RRB-
cord-265941-eff4le0g	143	10	.	.	.
cord-265941-eff4le0g	144	1	In	in	IN
cord-265941-eff4le0g	144	2	the	the	DT
cord-265941-eff4le0g	144	3	absence	absence	NN
cord-265941-eff4le0g	144	4	of	of	IN
cord-265941-eff4le0g	144	5	caspase	caspase	NN
cord-265941-eff4le0g	144	6	activity	activity	NN
cord-265941-eff4le0g	144	7	,	,	,
cord-265941-eff4le0g	144	8	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	144	9	and	and	CC
cord-265941-eff4le0g	144	10	RIPK3	ripk3	NN
cord-265941-eff4le0g	144	11	oligomerize	oligomerize	NNP
cord-265941-eff4le0g	144	12	to	to	TO
cord-265941-eff4le0g	144	13	form	form	VB
cord-265941-eff4le0g	144	14	complex	complex	JJ
cord-265941-eff4le0g	144	15	IIc	IIc	NNP
cord-265941-eff4le0g	144	16	(	(	-LRB-
cord-265941-eff4le0g	144	17	necrosome	necrosome	NNP
cord-265941-eff4le0g	144	18	)	)	-RRB-
cord-265941-eff4le0g	144	19	that	that	WDT
cord-265941-eff4le0g	144	20	phosphorylates	phosphorylate	VBZ
cord-265941-eff4le0g	144	21	MLKL	MLKL	NNP
cord-265941-eff4le0g	144	22	and	and	CC
cord-265941-eff4le0g	144	23	induces	induce	VBZ
cord-265941-eff4le0g	144	24	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	144	25	[	[	-LRB-
cord-265941-eff4le0g	144	26	59	59	CD
cord-265941-eff4le0g	144	27	]	]	-RRB-
cord-265941-eff4le0g	144	28	[	[	-LRB-
cord-265941-eff4le0g	144	29	60	60	CD
cord-265941-eff4le0g	144	30	]	]	-RRB-
cord-265941-eff4le0g	144	31	[	[	-LRB-
cord-265941-eff4le0g	144	32	61	61	CD
cord-265941-eff4le0g	144	33	]	]	-RRB-
cord-265941-eff4le0g	144	34	.	.	.
cord-265941-eff4le0g	145	1	TLR	TLR	NNP
cord-265941-eff4le0g	145	2	-	-	HYPH
cord-265941-eff4le0g	145	3	driven	drive	VBN
cord-265941-eff4le0g	145	4	TRIF	TRIF	NNP
cord-265941-eff4le0g	145	5	-	-	HYPH
cord-265941-eff4le0g	145	6	RIPK1	ripk1	JJ
cord-265941-eff4le0g	145	7	interactions	interaction	NNS
cord-265941-eff4le0g	145	8	can	can	MD
cord-265941-eff4le0g	145	9	also	also	RB
cord-265941-eff4le0g	145	10	promote	promote	VB
cord-265941-eff4le0g	145	11	ripoptosome	ripoptosome	NN
cord-265941-eff4le0g	145	12	formation	formation	NN
cord-265941-eff4le0g	145	13	[	[	-LRB-
cord-265941-eff4le0g	145	14	62	62	CD
cord-265941-eff4le0g	145	15	]	]	-RRB-
cord-265941-eff4le0g	145	16	,	,	,
cord-265941-eff4le0g	145	17	while	while	IN
cord-265941-eff4le0g	145	18	TRIF	TRIF	NNP
cord-265941-eff4le0g	145	19	-	-	HYPH
cord-265941-eff4le0g	145	20	RIPK3	ripk3	NN
cord-265941-eff4le0g	145	21	phosphorylates	phosphorylate	VBZ
cord-265941-eff4le0g	145	22	MLKL	MLKL	NNP
cord-265941-eff4le0g	145	23	for	for	IN
cord-265941-eff4le0g	145	24	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	145	25	[	[	-LRB-
cord-265941-eff4le0g	145	26	63	63	CD
cord-265941-eff4le0g	145	27	]	]	-RRB-
cord-265941-eff4le0g	145	28	.	.	.
cord-265941-eff4le0g	146	1	Following	follow	VBG
cord-265941-eff4le0g	146	2	nucleic	nucleic	JJ
cord-265941-eff4le0g	146	3	acid	acid	NN
cord-265941-eff4le0g	146	4	sensing	sensing	NN
cord-265941-eff4le0g	146	5	,	,	,
cord-265941-eff4le0g	146	6	RHIM	RHIM	NNP
cord-265941-eff4le0g	146	7	interactions	interaction	NNS
cord-265941-eff4le0g	146	8	between	between	IN
cord-265941-eff4le0g	146	9	DAI	DAI	NNP
cord-265941-eff4le0g	146	10	/	/	SYM
cord-265941-eff4le0g	146	11	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	146	12	and	and	CC
cord-265941-eff4le0g	146	13	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	146	14	induces	induce	VBZ
cord-265941-eff4le0g	146	15	ripoptosome	ripoptosome	NNP
cord-265941-eff4le0g	146	16	formation	formation	NN
cord-265941-eff4le0g	146	17	or	or	CC
cord-265941-eff4le0g	146	18	direct	direct	JJ
cord-265941-eff4le0g	146	19	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	146	20	of	of	IN
cord-265941-eff4le0g	146	21	MLKL	MLKL	NNP
cord-265941-eff4le0g	146	22	[	[	-LRB-
cord-265941-eff4le0g	146	23	64	64	CD
cord-265941-eff4le0g	146	24	,	,	,
cord-265941-eff4le0g	146	25	65	65	CD
cord-265941-eff4le0g	146	26	]	]	-RRB-
cord-265941-eff4le0g	146	27	.	.	.
cord-265941-eff4le0g	147	1	However	however	RB
cord-265941-eff4le0g	147	2	,	,	,
cord-265941-eff4le0g	147	3	the	the	DT
cord-265941-eff4le0g	147	4	resulting	result	VBG
cord-265941-eff4le0g	147	5	necroptosis	necroptosis	NN
cord-265941-eff4le0g	147	6	can	can	MD
cord-265941-eff4le0g	147	7	be	be	VB
cord-265941-eff4le0g	147	8	suppressed	suppress	VBN
cord-265941-eff4le0g	147	9	by	by	IN
cord-265941-eff4le0g	147	10	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	147	11	RHIM	RHIM	NNP
cord-265941-eff4le0g	147	12	[	[	-LRB-
cord-265941-eff4le0g	147	13	66	66	CD
cord-265941-eff4le0g	147	14	,	,	,
cord-265941-eff4le0g	147	15	67	67	CD
cord-265941-eff4le0g	147	16	]	]	-RRB-
cord-265941-eff4le0g	147	17	.	.	.
cord-265941-eff4le0g	148	1	DAI	DAI	NNP
cord-265941-eff4le0g	148	2	/	/	SYM
cord-265941-eff4le0g	148	3	ZBP1-RIPK3	zbp1-ripk3	NN
cord-265941-eff4le0g	148	4	complexing	complexing	NN
cord-265941-eff4le0g	148	5	also	also	RB
cord-265941-eff4le0g	148	6	promotes	promote	VBZ
cord-265941-eff4le0g	148	7	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	148	8	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	148	9	activation	activation	NN
cord-265941-eff4le0g	148	10	and	and	CC
cord-265941-eff4le0g	148	11	death	death	NN
cord-265941-eff4le0g	148	12	via	via	IN
cord-265941-eff4le0g	148	13	pyroptosis	pyroptosis	NNP
cord-265941-eff4le0g	148	14	[	[	-LRB-
cord-265941-eff4le0g	148	15	68	68	CD
cord-265941-eff4le0g	148	16	,	,	,
cord-265941-eff4le0g	148	17	69	69	CD
cord-265941-eff4le0g	148	18	]	]	-RRB-
cord-265941-eff4le0g	148	19	.	.	.
cord-265941-eff4le0g	149	1	Virulence	virulence	NN
cord-265941-eff4le0g	149	2	factors	factor	NNS
cord-265941-eff4le0g	149	3	that	that	WDT
cord-265941-eff4le0g	149	4	interact	interact	VBP
cord-265941-eff4le0g	149	5	with	with	IN
cord-265941-eff4le0g	149	6	these	these	DT
cord-265941-eff4le0g	149	7	pathways	pathway	NNS
cord-265941-eff4le0g	149	8	are	be	VBP
cord-265941-eff4le0g	149	9	indicated	indicate	VBN
cord-265941-eff4le0g	149	10	,	,	,
cord-265941-eff4le0g	149	11	and	and	CC
cord-265941-eff4le0g	149	12	have	have	VBP
cord-265941-eff4le0g	149	13	been	be	VBN
cord-265941-eff4le0g	149	14	discussed	discuss	VBN
cord-265941-eff4le0g	149	15	in	in	IN
cord-265941-eff4le0g	149	16	the	the	DT
cord-265941-eff4le0g	149	17	main	main	JJ
cord-265941-eff4le0g	149	18	body	body	NN
cord-265941-eff4le0g	149	19	of	of	IN
cord-265941-eff4le0g	149	20	the	the	DT
cord-265941-eff4le0g	149	21	text	text	NN
cord-265941-eff4le0g	149	22	.	.	.
cord-265941-eff4le0g	150	1	cytokine	cytokine	JJ
cord-265941-eff4le0g	150	2	production	production	NN
cord-265941-eff4le0g	150	3	by	by	IN
cord-265941-eff4le0g	150	4	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	150	5	monocytes	monocyte	NNS
cord-265941-eff4le0g	150	6	and	and	CC
cord-265941-eff4le0g	150	7	neutrophils	neutrophil	NNS
cord-265941-eff4le0g	150	8	[	[	-LRB-
cord-265941-eff4le0g	150	9	80	80	CD
cord-265941-eff4le0g	150	10	]	]	-RRB-
cord-265941-eff4le0g	150	11	.	.	.
cord-265941-eff4le0g	151	1	Consequently	consequently	RB
cord-265941-eff4le0g	151	2	,	,	,
cord-265941-eff4le0g	151	3	Ripk1	ripk1	JJ
cord-265941-eff4le0g	151	4	K45A	K45A	NNP
cord-265941-eff4le0g	151	5	/	/	SYM
cord-265941-eff4le0g	151	6	K45A	K45A	NNP
cord-265941-eff4le0g	151	7	mice	mouse	NNS
cord-265941-eff4le0g	151	8	orally	orally	RB
cord-265941-eff4le0g	151	9	infected	infect	VBN
cord-265941-eff4le0g	151	10	with	with	IN
cord-265941-eff4le0g	151	11	Y.	Y.	NNP
cord-265941-eff4le0g	151	12	pseudotuberculosis	pseudotuberculosis	NN
cord-265941-eff4le0g	151	13	exhibit	exhibit	NN
cord-265941-eff4le0g	151	14	decreased	decrease	VBD
cord-265941-eff4le0g	151	15	caspase-3	caspase-3	NNP
cord-265941-eff4le0g	151	16	staining	stain	VBG
cord-265941-eff4le0g	151	17	within	within	IN
cord-265941-eff4le0g	151	18	the	the	DT
cord-265941-eff4le0g	151	19	mesenteric	mesenteric	JJ
cord-265941-eff4le0g	151	20	lymph	lymph	NN
cord-265941-eff4le0g	151	21	nodes	node	NNS
cord-265941-eff4le0g	151	22	,	,	,
cord-265941-eff4le0g	151	23	as	as	RB
cord-265941-eff4le0g	151	24	well	well	RB
cord-265941-eff4le0g	151	25	as	as	IN
cord-265941-eff4le0g	151	26	reduced	reduce	VBN
cord-265941-eff4le0g	151	27	levels	level	NNS
cord-265941-eff4le0g	151	28	of	of	IN
cord-265941-eff4le0g	151	29	IL-12-producing	il-12-producing	NN
cord-265941-eff4le0g	151	30	monocytes	monocyte	NNS
cord-265941-eff4le0g	151	31	and	and	CC
cord-265941-eff4le0g	151	32	TNF	tnf	NN
cord-265941-eff4le0g	151	33	-	-	HYPH
cord-265941-eff4le0g	151	34	producing	produce	VBG
cord-265941-eff4le0g	151	35	neutrophils	neutrophil	NNS
cord-265941-eff4le0g	151	36	.	.	.
cord-265941-eff4le0g	152	1	These	these	DT
cord-265941-eff4le0g	152	2	mice	mouse	NNS
cord-265941-eff4le0g	152	3	are	be	VBP
cord-265941-eff4le0g	152	4	unable	unable	JJ
cord-265941-eff4le0g	152	5	to	to	TO
cord-265941-eff4le0g	152	6	restrict	restrict	VB
cord-265941-eff4le0g	152	7	bacterial	bacterial	JJ
cord-265941-eff4le0g	152	8	replication	replication	NN
cord-265941-eff4le0g	152	9	and	and	CC
cord-265941-eff4le0g	152	10	systemic	systemic	JJ
cord-265941-eff4le0g	152	11	dissemination	dissemination	NN
cord-265941-eff4le0g	152	12	,	,	,
cord-265941-eff4le0g	152	13	resulting	result	VBG
cord-265941-eff4le0g	152	14	in	in	IN
cord-265941-eff4le0g	152	15	rapid	rapid	JJ
cord-265941-eff4le0g	152	16	mortality	mortality	NN
cord-265941-eff4le0g	152	17	.	.	.
cord-265941-eff4le0g	153	1	Necroptosis	Necroptosis	NNP
cord-265941-eff4le0g	153	2	has	have	VBZ
cord-265941-eff4le0g	153	3	largely	largely	RB
cord-265941-eff4le0g	153	4	been	be	VBN
cord-265941-eff4le0g	153	5	studied	study	VBN
cord-265941-eff4le0g	153	6	in	in	IN
cord-265941-eff4le0g	153	7	the	the	DT
cord-265941-eff4le0g	153	8	context	context	NN
cord-265941-eff4le0g	153	9	of	of	IN
cord-265941-eff4le0g	153	10	antiviral	antiviral	JJ
cord-265941-eff4le0g	153	11	responses	response	NNS
cord-265941-eff4le0g	153	12	,	,	,
cord-265941-eff4le0g	153	13	often	often	RB
cord-265941-eff4le0g	153	14	as	as	IN
cord-265941-eff4le0g	153	15	an	an	DT
cord-265941-eff4le0g	153	16	alternate	alternate	JJ
cord-265941-eff4le0g	153	17	form	form	NN
cord-265941-eff4le0g	153	18	of	of	IN
cord-265941-eff4le0g	153	19	cell	cell	NN
cord-265941-eff4le0g	153	20	death	death	NN
cord-265941-eff4le0g	153	21	for	for	IN
cord-265941-eff4le0g	153	22	restricting	restrict	VBG
cord-265941-eff4le0g	153	23	viral	viral	JJ
cord-265941-eff4le0g	153	24	replication	replication	NN
cord-265941-eff4le0g	153	25	.	.	.
cord-265941-eff4le0g	154	1	Necroptosis	Necroptosis	NNP
cord-265941-eff4le0g	154	2	is	be	VBZ
cord-265941-eff4le0g	154	3	a	a	DT
cord-265941-eff4le0g	154	4	form	form	NN
cord-265941-eff4le0g	154	5	of	of	IN
cord-265941-eff4le0g	154	6	regulated	regulated	JJ
cord-265941-eff4le0g	154	7	lytic	lytic	JJ
cord-265941-eff4le0g	154	8	cell	cell	NN
cord-265941-eff4le0g	154	9	death	death	NN
cord-265941-eff4le0g	154	10	that	that	WDT
cord-265941-eff4le0g	154	11	operates	operate	VBZ
cord-265941-eff4le0g	154	12	independent	independent	JJ
cord-265941-eff4le0g	154	13	of	of	IN
cord-265941-eff4le0g	154	14	caspases	caspase	NNS
cord-265941-eff4le0g	154	15	,	,	,
cord-265941-eff4le0g	154	16	and	and	CC
cord-265941-eff4le0g	154	17	requires	require	VBZ
cord-265941-eff4le0g	154	18	both	both	DT
cord-265941-eff4le0g	154	19	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	154	20	and	and	CC
cord-265941-eff4le0g	154	21	MLKL	MLKL	NNP
cord-265941-eff4le0g	154	22	function	function	NN
cord-265941-eff4le0g	154	23	(	(	-LRB-
cord-265941-eff4le0g	154	24	Fig	fig	NN
cord-265941-eff4le0g	154	25	.	.	NNP
cord-265941-eff4le0g	154	26	2	2	CD
cord-265941-eff4le0g	154	27	)	)	-RRB-
cord-265941-eff4le0g	154	28	.	.	.
cord-265941-eff4le0g	155	1	It	-PRON-	PRP
cord-265941-eff4le0g	155	2	is	be	VBZ
cord-265941-eff4le0g	155	3	important	important	JJ
cord-265941-eff4le0g	155	4	to	to	TO
cord-265941-eff4le0g	155	5	note	note	VB
cord-265941-eff4le0g	155	6	that	that	IN
cord-265941-eff4le0g	155	7	although	although	IN
cord-265941-eff4le0g	155	8	the	the	DT
cord-265941-eff4le0g	155	9	studies	study	NNS
cord-265941-eff4le0g	155	10	discussed	discuss	VBN
cord-265941-eff4le0g	155	11	below	below	RB
cord-265941-eff4le0g	155	12	have	have	VBP
cord-265941-eff4le0g	155	13	specified	specify	VBN
cord-265941-eff4le0g	155	14	necroptosis	necroptosis	NN
cord-265941-eff4le0g	155	15	as	as	IN
cord-265941-eff4le0g	155	16	the	the	DT
cord-265941-eff4le0g	155	17	specific	specific	JJ
cord-265941-eff4le0g	155	18	cell	cell	NN
cord-265941-eff4le0g	155	19	death	death	NN
cord-265941-eff4le0g	155	20	outcome	outcome	NN
cord-265941-eff4le0g	155	21	involved	involve	VBN
cord-265941-eff4le0g	155	22	in	in	IN
cord-265941-eff4le0g	155	23	the	the	DT
cord-265941-eff4le0g	155	24	infection	infection	NN
cord-265941-eff4le0g	155	25	process	process	NN
cord-265941-eff4le0g	155	26	,	,	,
cord-265941-eff4le0g	155	27	some	some	DT
cord-265941-eff4le0g	155	28	have	have	VBP
cord-265941-eff4le0g	155	29	only	only	RB
cord-265941-eff4le0g	155	30	documented	document	VBN
cord-265941-eff4le0g	155	31	RIPK3	ripk3	NN
cord-265941-eff4le0g	155	32	dependence	dependence	NN
cord-265941-eff4le0g	155	33	but	but	CC
cord-265941-eff4le0g	155	34	have	have	VBP
cord-265941-eff4le0g	155	35	not	not	RB
cord-265941-eff4le0g	155	36	directly	directly	RB
cord-265941-eff4le0g	155	37	shown	show	VBN
cord-265941-eff4le0g	155	38	involvement	involvement	NN
cord-265941-eff4le0g	155	39	of	of	IN
cord-265941-eff4le0g	155	40	MLKL	MLKL	NNP
cord-265941-eff4le0g	155	41	or	or	CC
cord-265941-eff4le0g	155	42	pMLKL	pmlkl	NN
cord-265941-eff4le0g	155	43	.	.	.
cord-265941-eff4le0g	156	1	Therefore	therefore	RB
cord-265941-eff4le0g	156	2	,	,	,
cord-265941-eff4le0g	156	3	we	-PRON-	PRP
cord-265941-eff4le0g	156	4	have	have	VBP
cord-265941-eff4le0g	156	5	noted	note	VBN
cord-265941-eff4le0g	156	6	whether	whether	IN
cord-265941-eff4le0g	156	7	experimental	experimental	JJ
cord-265941-eff4le0g	156	8	evidence	evidence	NN
cord-265941-eff4le0g	156	9	has	have	VBZ
cord-265941-eff4le0g	156	10	been	be	VBN
cord-265941-eff4le0g	156	11	provided	provide	VBN
cord-265941-eff4le0g	156	12	for	for	IN
cord-265941-eff4le0g	156	13	dependence	dependence	NN
cord-265941-eff4le0g	156	14	on	on	IN
cord-265941-eff4le0g	156	15	MLKL	MLKL	NNP
cord-265941-eff4le0g	156	16	within	within	IN
cord-265941-eff4le0g	156	17	the	the	DT
cord-265941-eff4le0g	156	18	text	text	NN
cord-265941-eff4le0g	156	19	.	.	.
cord-265941-eff4le0g	157	1	Mouse	mouse	NN
cord-265941-eff4le0g	157	2	fibroblasts	fibroblast	NNS
cord-265941-eff4le0g	157	3	infected	infect	VBN
cord-265941-eff4le0g	157	4	with	with	IN
cord-265941-eff4le0g	157	5	vaccinia	vaccinia	NN
cord-265941-eff4le0g	157	6	virus	virus	NN
cord-265941-eff4le0g	157	7	(	(	-LRB-
cord-265941-eff4le0g	157	8	VV	VV	NNP
cord-265941-eff4le0g	157	9	)	)	-RRB-
cord-265941-eff4le0g	157	10	,	,	,
cord-265941-eff4le0g	157	11	which	which	WDT
cord-265941-eff4le0g	157	12	is	be	VBZ
cord-265941-eff4le0g	157	13	a	a	DT
cord-265941-eff4le0g	157	14	poxvirus	poxvirus	JJ
cord-265941-eff4le0g	157	15	strain	strain	NN
cord-265941-eff4le0g	157	16	that	that	WDT
cord-265941-eff4le0g	157	17	encodes	encode	VBZ
cord-265941-eff4le0g	157	18	the	the	DT
cord-265941-eff4le0g	157	19	caspase	caspase	JJ
cord-265941-eff4le0g	157	20	inhibitor	inhibitor	NN
cord-265941-eff4le0g	157	21	B13R	b13r	NN
cord-265941-eff4le0g	157	22	/	/	,
cord-265941-eff4le0g	157	23	Spi2	Spi2	NNP
cord-265941-eff4le0g	157	24	,	,	,
cord-265941-eff4le0g	157	25	are	be	VBP
cord-265941-eff4le0g	157	26	shown	show	VBN
cord-265941-eff4le0g	157	27	to	to	TO
cord-265941-eff4le0g	157	28	have	have	VB
cord-265941-eff4le0g	157	29	resistance	resistance	NN
cord-265941-eff4le0g	157	30	to	to	IN
cord-265941-eff4le0g	157	31	TNF	TNF	NNP
cord-265941-eff4le0g	157	32	-	-	HYPH
cord-265941-eff4le0g	157	33	induced	induce	VBN
cord-265941-eff4le0g	157	34	apoptosis	apoptosis	NN
cord-265941-eff4le0g	157	35	but	but	CC
cord-265941-eff4le0g	157	36	increased	increase	VBN
cord-265941-eff4le0g	157	37	sensitivity	sensitivity	NN
cord-265941-eff4le0g	157	38	to	to	IN
cord-265941-eff4le0g	157	39	RIPK3-dependent	RIPK3-dependent	NNP
cord-265941-eff4le0g	157	40	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	157	41	[	[	-LRB-
cord-265941-eff4le0g	157	42	81	81	CD
cord-265941-eff4le0g	157	43	,	,	,
cord-265941-eff4le0g	157	44	82	82	CD
cord-265941-eff4le0g	157	45	]	]	-RRB-
cord-265941-eff4le0g	157	46	.	.	.
cord-265941-eff4le0g	158	1	VV	VV	NNP
cord-265941-eff4le0g	158	2	-	-	HYPH
cord-265941-eff4le0g	158	3	infected	infect	VBN
cord-265941-eff4le0g	158	4	WT	WT	NNP
cord-265941-eff4le0g	158	5	mice	mouse	NNS
cord-265941-eff4le0g	158	6	exhibit	exhibit	VBP
cord-265941-eff4le0g	158	7	extensive	extensive	JJ
cord-265941-eff4le0g	158	8	inflammation	inflammation	NN
cord-265941-eff4le0g	158	9	and	and	CC
cord-265941-eff4le0g	158	10	necrotic	necrotic	JJ
cord-265941-eff4le0g	158	11	tissue	tissue	NN
cord-265941-eff4le0g	158	12	damage	damage	NN
cord-265941-eff4le0g	158	13	within	within	IN
cord-265941-eff4le0g	158	14	the	the	DT
cord-265941-eff4le0g	158	15	liver	liver	NN
cord-265941-eff4le0g	158	16	,	,	,
cord-265941-eff4le0g	158	17	associated	associate	VBN
cord-265941-eff4le0g	158	18	with	with	IN
cord-265941-eff4le0g	158	19	formation	formation	NN
cord-265941-eff4le0g	158	20	of	of	IN
cord-265941-eff4le0g	158	21	RIPK1-RIPK3	RIPK1-RIPK3	NNP
cord-265941-eff4le0g	158	22	complexes	complex	NNS
cord-265941-eff4le0g	158	23	[	[	-LRB-
cord-265941-eff4le0g	158	24	82	82	CD
cord-265941-eff4le0g	158	25	]	]	-RRB-
cord-265941-eff4le0g	158	26	.	.	.
cord-265941-eff4le0g	159	1	Ripk3	Ripk3	NNPS
cord-265941-eff4le0g	160	1	−	−	NNP
cord-265941-eff4le0g	161	1	/−	/−	.
cord-265941-eff4le0g	162	1	mice	mouse	NNS
cord-265941-eff4le0g	162	2	fail	fail	VBP
cord-265941-eff4le0g	162	3	to	to	TO
cord-265941-eff4le0g	162	4	initiate	initiate	VB
cord-265941-eff4le0g	162	5	virus	virus	NN
cord-265941-eff4le0g	162	6	-	-	HYPH
cord-265941-eff4le0g	162	7	induced	induce	VBN
cord-265941-eff4le0g	162	8	necroptosis	necroptosis	NN
cord-265941-eff4le0g	162	9	,	,	,
cord-265941-eff4le0g	162	10	resulting	result	VBG
cord-265941-eff4le0g	162	11	in	in	IN
cord-265941-eff4le0g	162	12	elevated	elevated	JJ
cord-265941-eff4le0g	162	13	viral	viral	JJ
cord-265941-eff4le0g	162	14	titres	titre	NNS
cord-265941-eff4le0g	162	15	and	and	CC
cord-265941-eff4le0g	162	16	mortality	mortality	NN
cord-265941-eff4le0g	162	17	[	[	-LRB-
cord-265941-eff4le0g	162	18	83	83	CD
cord-265941-eff4le0g	162	19	,	,	,
cord-265941-eff4le0g	162	20	84	84	CD
cord-265941-eff4le0g	162	21	]	]	-RRB-
cord-265941-eff4le0g	162	22	.	.	.
cord-265941-eff4le0g	163	1	The	the	DT
cord-265941-eff4le0g	163	2	requirement	requirement	NN
cord-265941-eff4le0g	163	3	for	for	IN
cord-265941-eff4le0g	163	4	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	163	5	kinase	kinase	NN
cord-265941-eff4le0g	163	6	activity	activity	NN
cord-265941-eff4le0g	163	7	remains	remain	VBZ
cord-265941-eff4le0g	163	8	unclear	unclear	JJ
cord-265941-eff4le0g	163	9	however	however	RB
cord-265941-eff4le0g	163	10	,	,	,
cord-265941-eff4le0g	163	11	as	as	IN
cord-265941-eff4le0g	163	12	groups	group	NNS
cord-265941-eff4le0g	163	13	have	have	VBP
cord-265941-eff4le0g	163	14	reported	report	VBN
cord-265941-eff4le0g	163	15	either	either	CC
cord-265941-eff4le0g	163	16	increased	increase	VBN
cord-265941-eff4le0g	163	17	[	[	-LRB-
cord-265941-eff4le0g	163	18	84	84	CD
cord-265941-eff4le0g	163	19	]	]	-RRB-
cord-265941-eff4le0g	163	20	or	or	CC
cord-265941-eff4le0g	163	21	unchanged	unchanged	JJ
cord-265941-eff4le0g	163	22	[	[	-LRB-
cord-265941-eff4le0g	163	23	85	85	CD
cord-265941-eff4le0g	163	24	]	]	-RRB-
cord-265941-eff4le0g	163	25	VV	VV	NNP
cord-265941-eff4le0g	163	26	loads	load	NNS
cord-265941-eff4le0g	163	27	within	within	IN
cord-265941-eff4le0g	163	28	the	the	DT
cord-265941-eff4le0g	163	29	liver	liver	NN
cord-265941-eff4le0g	163	30	and	and	CC
cord-265941-eff4le0g	163	31	spleen	spleen	NNS
cord-265941-eff4le0g	163	32	of	of	IN
cord-265941-eff4le0g	163	33	infected	infected	JJ
cord-265941-eff4le0g	163	34	Ripk1	ripk1	JJ
cord-265941-eff4le0g	163	35	D138N	D138N	NNP
cord-265941-eff4le0g	163	36	/	/	SYM
cord-265941-eff4le0g	163	37	D138N	D138N	NNP
cord-265941-eff4le0g	163	38	mice	mouse	NNS
cord-265941-eff4le0g	163	39	.	.	.
cord-265941-eff4le0g	164	1	VV	VV	NNP
cord-265941-eff4le0g	164	2	also	also	RB
cord-265941-eff4le0g	164	3	encodes	encode	VBZ
cord-265941-eff4le0g	164	4	E3L	e3l	NN
cord-265941-eff4le0g	164	5	,	,	,
cord-265941-eff4le0g	164	6	which	which	WDT
cord-265941-eff4le0g	164	7	contains	contain	VBZ
cord-265941-eff4le0g	164	8	an	an	DT
cord-265941-eff4le0g	164	9	N	n	CD
cord-265941-eff4le0g	164	10	-	-	HYPH
cord-265941-eff4le0g	164	11	terminal	terminal	NN
cord-265941-eff4le0g	164	12	Z	z	NN
cord-265941-eff4le0g	164	13	-	-	HYPH
cord-265941-eff4le0g	164	14	DNA	dna	NN
cord-265941-eff4le0g	164	15	binding	binding	NN
cord-265941-eff4le0g	164	16	domain	domain	NN
cord-265941-eff4le0g	164	17	that	that	WDT
cord-265941-eff4le0g	164	18	competes	compete	VBZ
cord-265941-eff4le0g	164	19	with	with	IN
cord-265941-eff4le0g	164	20	DAI	DAI	NNP
cord-265941-eff4le0g	164	21	to	to	TO
cord-265941-eff4le0g	164	22	inhibit	inhibit	VB
cord-265941-eff4le0g	164	23	DAI	DAI	NNP
cord-265941-eff4le0g	164	24	/	/	SYM
cord-265941-eff4le0g	164	25	RIPK3	ripk3	NN
cord-265941-eff4le0g	164	26	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	164	27	[	[	-LRB-
cord-265941-eff4le0g	164	28	86	86	CD
cord-265941-eff4le0g	164	29	,	,	,
cord-265941-eff4le0g	164	30	87	87	CD
cord-265941-eff4le0g	164	31	]	]	-RRB-
cord-265941-eff4le0g	164	32	.	.	.
cord-265941-eff4le0g	165	1	Administration	administration	NN
cord-265941-eff4le0g	165	2	of	of	IN
cord-265941-eff4le0g	165	3	an	an	DT
cord-265941-eff4le0g	165	4	E3L	e3l	NN
cord-265941-eff4le0g	165	5	mutant	mutant	JJ
cord-265941-eff4le0g	165	6	lacking	lack	VBG
cord-265941-eff4le0g	165	7	this	this	DT
cord-265941-eff4le0g	165	8	domain	domain	NN
cord-265941-eff4le0g	165	9	in	in	IN
cord-265941-eff4le0g	165	10	mouse	mouse	NN
cord-265941-eff4le0g	165	11	fibroblasts	fibroblast	NNS
cord-265941-eff4le0g	165	12	and	and	CC
cord-265941-eff4le0g	165	13	human	human	JJ
cord-265941-eff4le0g	165	14	epithelial	epithelial	JJ
cord-265941-eff4le0g	165	15	cells	cell	NNS
cord-265941-eff4le0g	165	16	results	result	NNS
cord-265941-eff4le0g	165	17	in	in	IN
cord-265941-eff4le0g	165	18	increased	increase	VBN
cord-265941-eff4le0g	165	19	IFN	IFN	NNP
cord-265941-eff4le0g	165	20	-	-	HYPH
cord-265941-eff4le0g	165	21	induced	induce	VBN
cord-265941-eff4le0g	165	22	necroptosis	necroptosis	NN
cord-265941-eff4le0g	165	23	,	,	,
cord-265941-eff4le0g	165	24	featuring	feature	VBG
cord-265941-eff4le0g	165	25	increased	increase	VBN
cord-265941-eff4le0g	165	26	MLKL	MLKL	NNP
cord-265941-eff4le0g	165	27	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	165	28	,	,	,
cord-265941-eff4le0g	165	29	and	and	CC
cord-265941-eff4le0g	165	30	fails	fail	VBZ
cord-265941-eff4le0g	165	31	to	to	TO
cord-265941-eff4le0g	165	32	elicit	elicit	VB
cord-265941-eff4le0g	165	33	disease	disease	NN
cord-265941-eff4le0g	165	34	in	in	IN
cord-265941-eff4le0g	165	35	WT	WT	NNP
cord-265941-eff4le0g	165	36	mice	mouse	NNS
cord-265941-eff4le0g	165	37	[	[	-LRB-
cord-265941-eff4le0g	165	38	87	87	CD
cord-265941-eff4le0g	165	39	]	]	-RRB-
cord-265941-eff4le0g	165	40	.	.	.
cord-265941-eff4le0g	166	1	Similarly	similarly	RB
cord-265941-eff4le0g	166	2	,	,	,
cord-265941-eff4le0g	166	3	MCMV	MCMV	NNP
cord-265941-eff4le0g	166	4	encodes	encode	VBZ
cord-265941-eff4le0g	166	5	a	a	DT
cord-265941-eff4le0g	166	6	viral	viral	JJ
cord-265941-eff4le0g	166	7	inhibitor	inhibitor	NN
cord-265941-eff4le0g	166	8	of	of	IN
cord-265941-eff4le0g	166	9	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	166	10	activation	activation	NN
cord-265941-eff4le0g	166	11	(	(	-LRB-
cord-265941-eff4le0g	166	12	vICA	vICA	NNP
cord-265941-eff4le0g	166	13	)	)	-RRB-
cord-265941-eff4le0g	166	14	,	,	,
cord-265941-eff4le0g	166	15	which	which	WDT
cord-265941-eff4le0g	166	16	blocks	block	VBZ
cord-265941-eff4le0g	166	17	DR	DR	NNP
cord-265941-eff4le0g	166	18	-	-	HYPH
cord-265941-eff4le0g	166	19	induced	induce	VBN
cord-265941-eff4le0g	166	20	apoptosis	apoptosis	NN
cord-265941-eff4le0g	166	21	but	but	CC
cord-265941-eff4le0g	166	22	sensitises	sensitise	NNS
cord-265941-eff4le0g	166	23	cells	cell	NNS
cord-265941-eff4le0g	166	24	to	to	IN
cord-265941-eff4le0g	166	25	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	166	26	[	[	-LRB-
cord-265941-eff4le0g	166	27	88	88	CD
cord-265941-eff4le0g	166	28	,	,	,
cord-265941-eff4le0g	166	29	89	89	CD
cord-265941-eff4le0g	166	30	]	]	-RRB-
cord-265941-eff4le0g	166	31	.	.	.
cord-265941-eff4le0g	167	1	To	to	TO
cord-265941-eff4le0g	167	2	combat	combat	VB
cord-265941-eff4le0g	167	3	this	this	DT
cord-265941-eff4le0g	167	4	,	,	,
cord-265941-eff4le0g	167	5	MCMV	MCMV	NNP
cord-265941-eff4le0g	167	6	expresses	express	VBZ
cord-265941-eff4le0g	167	7	the	the	DT
cord-265941-eff4le0g	167	8	viral	viral	JJ
cord-265941-eff4le0g	167	9	inhibitor	inhibitor	NN
cord-265941-eff4le0g	167	10	of	of	IN
cord-265941-eff4le0g	167	11	RIP	RIP	NNP
cord-265941-eff4le0g	167	12	activation	activation	NN
cord-265941-eff4le0g	167	13	(	(	-LRB-
cord-265941-eff4le0g	167	14	vIRA	vira	RB
cord-265941-eff4le0g	167	15	)	)	-RRB-
cord-265941-eff4le0g	167	16	,	,	,
cord-265941-eff4le0g	167	17	that	that	WDT
cord-265941-eff4le0g	167	18	binds	bind	VBZ
cord-265941-eff4le0g	167	19	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	167	20	and	and	CC
cord-265941-eff4le0g	167	21	RIPK3	ripk3	NN
cord-265941-eff4le0g	167	22	through	through	IN
cord-265941-eff4le0g	167	23	its	-PRON-	PRP$
cord-265941-eff4le0g	167	24	N	n	CD
cord-265941-eff4le0g	167	25	-	-	HYPH
cord-265941-eff4le0g	167	26	terminal	terminal	JJ
cord-265941-eff4le0g	167	27	RHIM	RHIM	NNP
cord-265941-eff4le0g	167	28	domain	domain	NN
cord-265941-eff4le0g	167	29	[	[	-LRB-
cord-265941-eff4le0g	167	30	90	90	CD
cord-265941-eff4le0g	167	31	]	]	-RRB-
cord-265941-eff4le0g	167	32	.	.	.
cord-265941-eff4le0g	168	1	vIRA	vIRA	NNP
cord-265941-eff4le0g	168	2	is	be	VBZ
cord-265941-eff4le0g	168	3	a	a	DT
cord-265941-eff4le0g	168	4	potent	potent	JJ
cord-265941-eff4le0g	168	5	inhibitor	inhibitor	NN
cord-265941-eff4le0g	168	6	for	for	IN
cord-265941-eff4le0g	168	7	MCMV	MCMV	NNP
cord-265941-eff4le0g	168	8	-	-	HYPH
cord-265941-eff4le0g	168	9	triggered	trigger	VBN
cord-265941-eff4le0g	168	10	necroptosis	necroptosis	NN
cord-265941-eff4le0g	168	11	that	that	WDT
cord-265941-eff4le0g	168	12	is	be	VBZ
cord-265941-eff4le0g	168	13	dependent	dependent	JJ
cord-265941-eff4le0g	168	14	on	on	IN
cord-265941-eff4le0g	168	15	DAI	DAI	NNP
cord-265941-eff4le0g	168	16	/	/	SYM
cord-265941-eff4le0g	168	17	RIPK3	ripk3	NN
cord-265941-eff4le0g	168	18	signaling	signal	VBG
cord-265941-eff4le0g	168	19	[	[	-LRB-
cord-265941-eff4le0g	168	20	91	91	CD
cord-265941-eff4le0g	168	21	]	]	-RRB-
cord-265941-eff4le0g	168	22	.	.	.
cord-265941-eff4le0g	169	1	MCMV	MCMV	NNP
cord-265941-eff4le0g	169	2	mutants	mutant	NNS
cord-265941-eff4le0g	169	3	lacking	lack	VBG
cord-265941-eff4le0g	169	4	vIRA	vira	RB
cord-265941-eff4le0g	169	5	or	or	CC
cord-265941-eff4le0g	169	6	its	-PRON-	PRP$
cord-265941-eff4le0g	169	7	RHIM	RHIM	NNP
cord-265941-eff4le0g	169	8	domain	domain	NN
cord-265941-eff4le0g	169	9	are	be	VBP
cord-265941-eff4le0g	169	10	severely	severely	RB
cord-265941-eff4le0g	169	11	attenuated	attenuate	VBN
cord-265941-eff4le0g	169	12	in	in	IN
cord-265941-eff4le0g	169	13	WT	WT	NNP
cord-265941-eff4le0g	169	14	mice	mouse	NNS
cord-265941-eff4le0g	169	15	,	,	,
cord-265941-eff4le0g	169	16	but	but	CC
cord-265941-eff4le0g	169	17	unaffected	unaffected	JJ
cord-265941-eff4le0g	169	18	in	in	IN
cord-265941-eff4le0g	169	19	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	169	20	−	−	NNP
cord-265941-eff4le0g	170	1	/−	/−	.
cord-265941-eff4le0g	171	1	and	and	CC
cord-265941-eff4le0g	171	2	Dai	Dai	NNP
cord-265941-eff4le0g	171	3	−	−	NNP
cord-265941-eff4le0g	172	1	/−	/−	.
cord-265941-eff4le0g	173	1	mice	mouse	NNS
cord-265941-eff4le0g	173	2	[	[	-LRB-
cord-265941-eff4le0g	173	3	91	91	CD
cord-265941-eff4le0g	173	4	]	]	-RRB-
cord-265941-eff4le0g	173	5	[	[	-LRB-
cord-265941-eff4le0g	173	6	92	92	CD
cord-265941-eff4le0g	173	7	]	]	-RRB-
cord-265941-eff4le0g	173	8	[	[	-LRB-
cord-265941-eff4le0g	173	9	93	93	CD
cord-265941-eff4le0g	173	10	]	]	-RRB-
cord-265941-eff4le0g	173	11	.	.	.
cord-265941-eff4le0g	174	1	Phosphorylation	Phosphorylation	NNP
cord-265941-eff4le0g	174	2	of	of	IN
cord-265941-eff4le0g	174	3	MLKL	MLKL	NNP
cord-265941-eff4le0g	174	4	occurs	occur	VBZ
cord-265941-eff4le0g	174	5	within	within	IN
cord-265941-eff4le0g	174	6	hours	hour	NNS
cord-265941-eff4le0g	174	7	during	during	IN
cord-265941-eff4le0g	174	8	in	in	IN
cord-265941-eff4le0g	174	9	vitro	vitro	FW
cord-265941-eff4le0g	174	10	infection	infection	NN
cord-265941-eff4le0g	174	11	with	with	IN
cord-265941-eff4le0g	174	12	vIRA	vira	JJ
cord-265941-eff4le0g	174	13	RHIM	rhim	NN
cord-265941-eff4le0g	174	14	mutant	mutant	JJ
cord-265941-eff4le0g	174	15	MCMV	MCMV	NNP
cord-265941-eff4le0g	174	16	,	,	,
cord-265941-eff4le0g	174	17	and	and	CC
cord-265941-eff4le0g	174	18	is	be	VBZ
cord-265941-eff4le0g	174	19	reliant	reliant	JJ
cord-265941-eff4le0g	174	20	on	on	IN
cord-265941-eff4le0g	174	21	IE3-mediated	ie3-mediated	JJ
cord-265941-eff4le0g	174	22	transcription	transcription	NN
cord-265941-eff4le0g	174	23	of	of	IN
cord-265941-eff4le0g	174	24	its	-PRON-	PRP$
cord-265941-eff4le0g	174	25	genome	genome	NN
cord-265941-eff4le0g	174	26	[	[	-LRB-
cord-265941-eff4le0g	174	27	94	94	CD
cord-265941-eff4le0g	174	28	]	]	-RRB-
cord-265941-eff4le0g	174	29	.	.	.
cord-265941-eff4le0g	175	1	Briefly	briefly	RB
cord-265941-eff4le0g	175	2	,	,	,
cord-265941-eff4le0g	175	3	HCMV	HCMV	NNP
cord-265941-eff4le0g	175	4	also	also	RB
cord-265941-eff4le0g	175	5	elicits	elicit	VBZ
cord-265941-eff4le0g	175	6	DAI	DAI	NNP
cord-265941-eff4le0g	175	7	-	-	HYPH
cord-265941-eff4le0g	175	8	mediated	mediate	VBN
cord-265941-eff4le0g	175	9	production	production	NN
cord-265941-eff4le0g	175	10	of	of	IN
cord-265941-eff4le0g	175	11	IFNs	ifn	NNS
cord-265941-eff4le0g	175	12	and	and	CC
cord-265941-eff4le0g	175	13	TNF	TNF	NNP
cord-265941-eff4le0g	175	14	-	-	HYPH
cord-265941-eff4le0g	175	15	induced	induce	VBN
cord-265941-eff4le0g	175	16	necroptosis	necroptosis	NN
cord-265941-eff4le0g	175	17	in	in	IN
cord-265941-eff4le0g	175	18	a	a	DT
cord-265941-eff4le0g	175	19	RIPK	ripk	NN
cord-265941-eff4le0g	175	20	-	-	HYPH
cord-265941-eff4le0g	175	21	regulated	regulate	VBN
cord-265941-eff4le0g	175	22	manner	manner	NN
cord-265941-eff4le0g	175	23	[	[	-LRB-
cord-265941-eff4le0g	175	24	21	21	CD
cord-265941-eff4le0g	175	25	,	,	,
cord-265941-eff4le0g	175	26	95	95	CD
cord-265941-eff4le0g	175	27	,	,	,
cord-265941-eff4le0g	175	28	96	96	CD
cord-265941-eff4le0g	175	29	]	]	-RRB-
cord-265941-eff4le0g	175	30	.	.	.
cord-265941-eff4le0g	176	1	Notably	notably	RB
cord-265941-eff4le0g	176	2	,	,	,
cord-265941-eff4le0g	176	3	the	the	DT
cord-265941-eff4le0g	176	4	TNF	TNF	NNP
cord-265941-eff4le0g	176	5	-	-	HYPH
cord-265941-eff4le0g	176	6	driven	drive	VBN
cord-265941-eff4le0g	176	7	cell	cell	NN
cord-265941-eff4le0g	176	8	death	death	NN
cord-265941-eff4le0g	176	9	is	be	VBZ
cord-265941-eff4le0g	176	10	inhibited	inhibit	VBN
cord-265941-eff4le0g	176	11	by	by	IN
cord-265941-eff4le0g	176	12	HCMV	HCMV	NNP
cord-265941-eff4le0g	176	13	-	-	HYPH
cord-265941-eff4le0g	176	14	encoded	encode	VBN
cord-265941-eff4le0g	176	15	IE1	ie1	NN
cord-265941-eff4le0g	176	16	through	through	IN
cord-265941-eff4le0g	176	17	a	a	DT
cord-265941-eff4le0g	176	18	yet	yet	RB
cord-265941-eff4le0g	176	19	unknown	unknown	JJ
cord-265941-eff4le0g	176	20	process	process	NN
cord-265941-eff4le0g	176	21	that	that	WDT
cord-265941-eff4le0g	176	22	occurs	occur	VBZ
cord-265941-eff4le0g	176	23	after	after	IN
cord-265941-eff4le0g	176	24	RIPK3	ripk3	NN
cord-265941-eff4le0g	176	25	activation	activation	NN
cord-265941-eff4le0g	176	26	and	and	CC
cord-265941-eff4le0g	176	27	MLKL	MLKL	NNP
cord-265941-eff4le0g	176	28	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	176	29	,	,	,
cord-265941-eff4le0g	176	30	thus	thus	RB
cord-265941-eff4le0g	176	31	distinguishing	distinguish	VBG
cord-265941-eff4le0g	176	32	the	the	DT
cord-265941-eff4le0g	176	33	immunosuppressive	immunosuppressive	JJ
cord-265941-eff4le0g	176	34	strategies	strategy	NNS
cord-265941-eff4le0g	176	35	of	of	IN
cord-265941-eff4le0g	176	36	HCMV	HCMV	NNP
cord-265941-eff4le0g	176	37	from	from	IN
cord-265941-eff4le0g	176	38	its	-PRON-	PRP$
cord-265941-eff4le0g	176	39	murine	murine	JJ
cord-265941-eff4le0g	176	40	counterpart	counterpart	NN
cord-265941-eff4le0g	176	41	[	[	-LRB-
cord-265941-eff4le0g	176	42	96	96	CD
cord-265941-eff4le0g	176	43	]	]	-RRB-
cord-265941-eff4le0g	176	44	.	.	.
cord-265941-eff4le0g	177	1	HSV-1	hsv-1	NN
cord-265941-eff4le0g	177	2	and	and	CC
cord-265941-eff4le0g	177	3	HSV-2	HSV-2	NNS
cord-265941-eff4le0g	177	4	modulate	modulate	VBP
cord-265941-eff4le0g	177	5	immune	immune	JJ
cord-265941-eff4le0g	177	6	responses	response	NNS
cord-265941-eff4le0g	177	7	in	in	IN
cord-265941-eff4le0g	177	8	a	a	DT
cord-265941-eff4le0g	177	9	manner	manner	NN
cord-265941-eff4le0g	177	10	similar	similar	JJ
cord-265941-eff4le0g	177	11	to	to	IN
cord-265941-eff4le0g	177	12	MCMV	MCMV	NNP
cord-265941-eff4le0g	177	13	.	.	.
cord-265941-eff4le0g	178	1	They	-PRON-	PRP
cord-265941-eff4le0g	178	2	carry	carry	VBP
cord-265941-eff4le0g	178	3	ICP6	ICP6	NNP
cord-265941-eff4le0g	178	4	and	and	CC
cord-265941-eff4le0g	178	5	ICP10	ICP10	NNP
cord-265941-eff4le0g	178	6	respectively	respectively	RB
cord-265941-eff4le0g	178	7	,	,	,
cord-265941-eff4le0g	178	8	which	which	WDT
cord-265941-eff4le0g	178	9	expresses	express	VBZ
cord-265941-eff4le0g	178	10	an	an	DT
cord-265941-eff4le0g	178	11	Nterminal	Nterminal	NNP
cord-265941-eff4le0g	178	12	RHIM	RHIM	NNP
cord-265941-eff4le0g	178	13	domain	domain	NN
cord-265941-eff4le0g	178	14	that	that	WDT
cord-265941-eff4le0g	178	15	mediates	mediate	VBZ
cord-265941-eff4le0g	178	16	RIPK1	ripk1	JJ
cord-265941-eff4le0g	178	17	and	and	CC
cord-265941-eff4le0g	178	18	RIPK3	ripk3	NN
cord-265941-eff4le0g	178	19	interaction	interaction	NN
cord-265941-eff4le0g	178	20	,	,	,
cord-265941-eff4le0g	178	21	leading	lead	VBG
cord-265941-eff4le0g	178	22	to	to	IN
cord-265941-eff4le0g	178	23	anti	anti	JJ
cord-265941-eff4le0g	178	24	-	-	JJ
cord-265941-eff4le0g	178	25	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	178	26	signaling	signaling	NN
cord-265941-eff4le0g	178	27	in	in	IN
cord-265941-eff4le0g	178	28	human	human	JJ
cord-265941-eff4le0g	178	29	cells	cell	NNS
cord-265941-eff4le0g	178	30	,	,	,
cord-265941-eff4le0g	178	31	but	but	CC
cord-265941-eff4le0g	178	32	pro	pro	JJ
cord-265941-eff4le0g	178	33	-	-	JJ
cord-265941-eff4le0g	178	34	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	178	35	death	death	NN
cord-265941-eff4le0g	178	36	in	in	IN
cord-265941-eff4le0g	178	37	mice	mouse	NNS
cord-265941-eff4le0g	178	38	[	[	-LRB-
cord-265941-eff4le0g	178	39	97	97	CD
cord-265941-eff4le0g	178	40	]	]	-RRB-
cord-265941-eff4le0g	178	41	[	[	-LRB-
cord-265941-eff4le0g	178	42	98	98	CD
cord-265941-eff4le0g	178	43	]	]	-RRB-
cord-265941-eff4le0g	178	44	[	[	-LRB-
cord-265941-eff4le0g	178	45	99	99	CD
cord-265941-eff4le0g	178	46	]	]	-RRB-
cord-265941-eff4le0g	178	47	.	.	.
cord-265941-eff4le0g	179	1	Expression	expression	NN
cord-265941-eff4le0g	179	2	of	of	IN
cord-265941-eff4le0g	179	3	ICP6/10	icp6/10	NN
cord-265941-eff4le0g	179	4	or	or	CC
cord-265941-eff4le0g	179	5	HSV	HSV	NNP
cord-265941-eff4le0g	179	6	challenge	challenge	NN
cord-265941-eff4le0g	179	7	in	in	IN
cord-265941-eff4le0g	179	8	human	human	JJ
cord-265941-eff4le0g	179	9	cells	cell	NNS
cord-265941-eff4le0g	179	10	causes	cause	VBZ
cord-265941-eff4le0g	179	11	competitive	competitive	JJ
cord-265941-eff4le0g	179	12	RHIM	rhim	NN
cord-265941-eff4le0g	179	13	binding	bind	VBG
cord-265941-eff4le0g	179	14	that	that	WDT
cord-265941-eff4le0g	179	15	prevents	prevent	VBZ
cord-265941-eff4le0g	179	16	RIPK1-RIPK3	RIPK1-RIPK3	NNP
cord-265941-eff4le0g	179	17	necrosome	necrosome	NN
cord-265941-eff4le0g	179	18	formation	formation	NN
cord-265941-eff4le0g	179	19	and	and	CC
cord-265941-eff4le0g	179	20	subsequent	subsequent	JJ
cord-265941-eff4le0g	179	21	TNF	TNF	NNP
cord-265941-eff4le0g	179	22	-	-	HYPH
cord-265941-eff4le0g	179	23	induced	induce	VBN
cord-265941-eff4le0g	179	24	MLKL	MLKL	NNP
cord-265941-eff4le0g	179	25	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	179	26	and	and	CC
cord-265941-eff4le0g	179	27	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	179	28	[	[	-LRB-
cord-265941-eff4le0g	179	29	97	97	CD
cord-265941-eff4le0g	179	30	,	,	,
cord-265941-eff4le0g	179	31	98	98	CD
cord-265941-eff4le0g	179	32	]	]	-RRB-
cord-265941-eff4le0g	179	33	.	.	.
cord-265941-eff4le0g	180	1	In	in	IN
cord-265941-eff4le0g	180	2	contrast	contrast	NN
cord-265941-eff4le0g	180	3	,	,	,
cord-265941-eff4le0g	180	4	ICP6	icp6	JJ
cord-265941-eff4le0g	180	5	interaction	interaction	NN
cord-265941-eff4le0g	180	6	with	with	IN
cord-265941-eff4le0g	180	7	RIPKs	ripks	NN
cord-265941-eff4le0g	180	8	in	in	IN
cord-265941-eff4le0g	180	9	mouse	mouse	NN
cord-265941-eff4le0g	180	10	cells	cell	NNS
cord-265941-eff4le0g	180	11	promotes	promote	VBZ
cord-265941-eff4le0g	180	12	RIPK3-RIPK3	RIPK3-RIPK3	NNP
cord-265941-eff4le0g	180	13	complex	complex	JJ
cord-265941-eff4le0g	180	14	formation	formation	NN
cord-265941-eff4le0g	180	15	for	for	IN
cord-265941-eff4le0g	180	16	MLKL	MLKL	NNP
cord-265941-eff4le0g	180	17	recruitment	recruitment	NN
cord-265941-eff4le0g	180	18	and	and	CC
cord-265941-eff4le0g	180	19	execution	execution	NN
cord-265941-eff4le0g	180	20	of	of	IN
cord-265941-eff4le0g	180	21	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	180	22	,	,	,
cord-265941-eff4le0g	180	23	independent	independent	JJ
cord-265941-eff4le0g	180	24	of	of	IN
cord-265941-eff4le0g	180	25	DR	DR	NNP
cord-265941-eff4le0g	180	26	,	,	,
cord-265941-eff4le0g	180	27	DAI	DAI	NNP
cord-265941-eff4le0g	180	28	and	and	CC
cord-265941-eff4le0g	180	29	TLR	TLR	NNP
cord-265941-eff4le0g	181	1	signaling	signal	VBG
cord-265941-eff4le0g	181	2	[	[	-LRB-
cord-265941-eff4le0g	181	3	98	98	CD
cord-265941-eff4le0g	181	4	,	,	,
cord-265941-eff4le0g	181	5	99	99	CD
cord-265941-eff4le0g	181	6	]	]	-RRB-
cord-265941-eff4le0g	181	7	.	.	.
cord-265941-eff4le0g	182	1	This	this	DT
cord-265941-eff4le0g	182	2	RIPK3-dependent	RIPK3-dependent	:
cord-265941-eff4le0g	182	3	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	182	4	is	be	VBZ
cord-265941-eff4le0g	182	5	crucial	crucial	JJ
cord-265941-eff4le0g	182	6	for	for	IN
cord-265941-eff4le0g	182	7	controlling	control	VBG
cord-265941-eff4le0g	182	8	HSV-1	hsv-1	NN
cord-265941-eff4le0g	182	9	propagation	propagation	NN
cord-265941-eff4le0g	182	10	,	,	,
cord-265941-eff4le0g	182	11	as	as	IN
cord-265941-eff4le0g	182	12	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	182	13	−	−	NNP
cord-265941-eff4le0g	182	14	/−	/−	.
cord-265941-eff4le0g	182	15	mice	mouse	NNS
cord-265941-eff4le0g	182	16	present	present	JJ
cord-265941-eff4le0g	182	17	with	with	IN
cord-265941-eff4le0g	182	18	markedly	markedly	RB
cord-265941-eff4le0g	182	19	elevated	elevated	JJ
cord-265941-eff4le0g	182	20	susceptibility	susceptibility	NN
cord-265941-eff4le0g	182	21	to	to	IN
cord-265941-eff4le0g	182	22	infection	infection	NN
cord-265941-eff4le0g	182	23	and	and	CC
cord-265941-eff4le0g	182	24	death	death	NN
cord-265941-eff4le0g	182	25	,	,	,
cord-265941-eff4le0g	182	26	not	not	RB
cord-265941-eff4le0g	182	27	seen	see	VBN
cord-265941-eff4le0g	182	28	in	in	IN
cord-265941-eff4le0g	182	29	WT	WT	NNP
cord-265941-eff4le0g	182	30	mice	mouse	NNS
cord-265941-eff4le0g	182	31	.	.	.
cord-265941-eff4le0g	183	1	As	as	IN
cord-265941-eff4le0g	183	2	mentioned	mention	VBN
cord-265941-eff4le0g	183	3	previously	previously	RB
cord-265941-eff4le0g	183	4	,	,	,
cord-265941-eff4le0g	183	5	human	human	JJ
cord-265941-eff4le0g	183	6	γ	γ	NN
cord-265941-eff4le0g	183	7	-	-	HYPH
cord-265941-eff4le0g	183	8	herpesvirus	herpesvirus	NN
cord-265941-eff4le0g	183	9	EBV	EBV	NNP
cord-265941-eff4le0g	183	10	binds	bind	VBZ
cord-265941-eff4le0g	183	11	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	183	12	and	and	CC
cord-265941-eff4le0g	183	13	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	183	14	through	through	IN
cord-265941-eff4le0g	183	15	the	the	DT
cord-265941-eff4le0g	183	16	C	C	NNP
cord-265941-eff4le0g	183	17	-	-	HYPH
cord-265941-eff4le0g	183	18	terminal	terminal	NN
cord-265941-eff4le0g	183	19	activation	activation	NN
cord-265941-eff4le0g	183	20	region	region	NN
cord-265941-eff4le0g	183	21	of	of	IN
cord-265941-eff4le0g	183	22	its	-PRON-	PRP$
cord-265941-eff4le0g	183	23	encoded	encode	VBN
cord-265941-eff4le0g	183	24	LMP1	LMP1	NNP
cord-265941-eff4le0g	183	25	effector	effector	NN
cord-265941-eff4le0g	183	26	,	,	,
cord-265941-eff4le0g	183	27	which	which	WDT
cord-265941-eff4le0g	183	28	prevents	prevent	VBZ
cord-265941-eff4le0g	183	29	RIPK1-RIPK3	RIPK1-RIPK3	NNP
cord-265941-eff4le0g	183	30	complex	complex	JJ
cord-265941-eff4le0g	183	31	formation	formation	NN
cord-265941-eff4le0g	183	32	in	in	IN
cord-265941-eff4le0g	183	33	human	human	JJ
cord-265941-eff4le0g	183	34	nasopharyngeal	nasopharyngeal	JJ
cord-265941-eff4le0g	183	35	cells	cell	NNS
cord-265941-eff4le0g	183	36	[	[	-LRB-
cord-265941-eff4le0g	183	37	35	35	CD
cord-265941-eff4le0g	183	38	]	]	-RRB-
cord-265941-eff4le0g	183	39	.	.	.
cord-265941-eff4le0g	184	1	Moreover	moreover	RB
cord-265941-eff4le0g	184	2	,	,	,
cord-265941-eff4le0g	184	3	LMP1	LMP1	NNP
cord-265941-eff4le0g	184	4	promotes	promote	VBZ
cord-265941-eff4le0g	184	5	K63-linked	K63-linked	NNP
cord-265941-eff4le0g	184	6	polyubiquitylation	polyubiquitylation	NN
cord-265941-eff4le0g	184	7	of	of	IN
cord-265941-eff4le0g	184	8	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	184	9	that	that	WDT
cord-265941-eff4le0g	184	10	forms	form	VBZ
cord-265941-eff4le0g	184	11	the	the	DT
cord-265941-eff4le0g	184	12	scaffolding	scaffolding	NN
cord-265941-eff4le0g	184	13	required	require	VBN
cord-265941-eff4le0g	184	14	for	for	IN
cord-265941-eff4le0g	184	15	TNF	TNF	NNP
cord-265941-eff4le0g	184	16	-	-	HYPH
cord-265941-eff4le0g	184	17	induced	induce	VBN
cord-265941-eff4le0g	184	18	NFĸB	NFĸB	NNP
cord-265941-eff4le0g	184	19	signaling	signal	VBG
cord-265941-eff4le0g	184	20	[	[	-LRB-
cord-265941-eff4le0g	184	21	13	13	CD
cord-265941-eff4le0g	184	22	]	]	-RRB-
cord-265941-eff4le0g	184	23	,	,	,
cord-265941-eff4le0g	184	24	while	while	IN
cord-265941-eff4le0g	184	25	inhibiting	inhibit	VBG
cord-265941-eff4le0g	184	26	K63-linked	K63-linked	NNP
cord-265941-eff4le0g	184	27	polyubiquitylation	polyubiquitylation	NN
cord-265941-eff4le0g	184	28	of	of	IN
cord-265941-eff4le0g	184	29	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	184	30	that	that	WDT
cord-265941-eff4le0g	184	31	typically	typically	RB
cord-265941-eff4le0g	184	32	supports	support	VBZ
cord-265941-eff4le0g	184	33	necrosome	necrosome	NNP
cord-265941-eff4le0g	184	34	assembly	assembly	NNP
cord-265941-eff4le0g	184	35	[	[	-LRB-
cord-265941-eff4le0g	184	36	35	35	CD
cord-265941-eff4le0g	184	37	,	,	,
cord-265941-eff4le0g	184	38	100	100	CD
cord-265941-eff4le0g	184	39	]	]	-RRB-
cord-265941-eff4le0g	184	40	.	.	.
cord-265941-eff4le0g	185	1	These	these	DT
cord-265941-eff4le0g	185	2	post	post	JJ
cord-265941-eff4le0g	185	3	-	-	JJ
cord-265941-eff4le0g	185	4	translational	translational	JJ
cord-265941-eff4le0g	185	5	modifications	modification	NNS
cord-265941-eff4le0g	185	6	drive	drive	VBP
cord-265941-eff4le0g	185	7	a	a	DT
cord-265941-eff4le0g	185	8	switch	switch	NN
cord-265941-eff4le0g	185	9	from	from	IN
cord-265941-eff4le0g	185	10	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	185	11	death	death	NN
cord-265941-eff4le0g	185	12	to	to	IN
cord-265941-eff4le0g	185	13	a	a	DT
cord-265941-eff4le0g	185	14	pro	pro	JJ
cord-265941-eff4le0g	185	15	-	-	JJ
cord-265941-eff4le0g	185	16	survival	survival	JJ
cord-265941-eff4le0g	185	17	cell	cell	NN
cord-265941-eff4le0g	185	18	fate	fate	NN
cord-265941-eff4le0g	185	19	,	,	,
cord-265941-eff4le0g	185	20	as	as	IN
cord-265941-eff4le0g	185	21	indicated	indicate	VBN
cord-265941-eff4le0g	185	22	by	by	IN
cord-265941-eff4le0g	185	23	the	the	DT
cord-265941-eff4le0g	185	24	suppressed	suppress	VBN
cord-265941-eff4le0g	185	25	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	185	26	and	and	CC
cord-265941-eff4le0g	185	27	MLKL	MLKL	NNP
cord-265941-eff4le0g	185	28	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	185	29	following	follow	VBG
cord-265941-eff4le0g	185	30	EBV	EBV	NNP
cord-265941-eff4le0g	185	31	infection	infection	NN
cord-265941-eff4le0g	185	32	in	in	IN
cord-265941-eff4le0g	185	33	TNF	TNF	NNP
cord-265941-eff4le0g	185	34	-	-	HYPH
cord-265941-eff4le0g	185	35	induced	induce	VBN
cord-265941-eff4le0g	185	36	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	185	37	cells	cell	NNS
cord-265941-eff4le0g	185	38	[	[	-LRB-
cord-265941-eff4le0g	185	39	35	35	CD
cord-265941-eff4le0g	185	40	]	]	-RRB-
cord-265941-eff4le0g	185	41	.	.	.
cord-265941-eff4le0g	186	1	As	as	IN
cord-265941-eff4le0g	186	2	opposed	oppose	VBN
cord-265941-eff4le0g	186	3	to	to	IN
cord-265941-eff4le0g	186	4	targeting	target	VBG
cord-265941-eff4le0g	186	5	the	the	DT
cord-265941-eff4le0g	186	6	RHIM	RHIM	NNP
cord-265941-eff4le0g	186	7	sequences	sequence	NNS
cord-265941-eff4le0g	186	8	of	of	IN
cord-265941-eff4le0g	186	9	RIPKs	ripks	NN
cord-265941-eff4le0g	186	10	,	,	,
cord-265941-eff4le0g	186	11	BeAn	BeAn	NNP
cord-265941-eff4le0g	186	12	58058	58058	CD
cord-265941-eff4le0g	186	13	poxvirus	poxvirus	NNP
cord-265941-eff4le0g	186	14	(	(	-LRB-
cord-265941-eff4le0g	186	15	BAV	BAV	NNP
cord-265941-eff4le0g	186	16	)	)	-RRB-
cord-265941-eff4le0g	186	17	and	and	CC
cord-265941-eff4le0g	186	18	Cotia	Cotia	NNP
cord-265941-eff4le0g	186	19	poxvirus	poxvirus	NNP
cord-265941-eff4le0g	186	20	(	(	-LRB-
cord-265941-eff4le0g	186	21	COTV	COTV	NNP
cord-265941-eff4le0g	186	22	)	)	-RRB-
cord-265941-eff4le0g	186	23	carry	carry	VBP
cord-265941-eff4le0g	186	24	viral	viral	JJ
cord-265941-eff4le0g	186	25	MLKL	mlkl	NN
cord-265941-eff4le0g	186	26	-	-	HYPH
cord-265941-eff4le0g	186	27	like	like	JJ
cord-265941-eff4le0g	186	28	proteins	protein	NNS
cord-265941-eff4le0g	186	29	(	(	-LRB-
cord-265941-eff4le0g	186	30	vMLKL	vmlkl	NN
cord-265941-eff4le0g	186	31	)	)	-RRB-
cord-265941-eff4le0g	186	32	that	that	WDT
cord-265941-eff4le0g	186	33	block	block	NN
cord-265941-eff4le0g	186	34	necroptosis	necroptosis	NN
cord-265941-eff4le0g	186	35	by	by	IN
cord-265941-eff4le0g	186	36	interacting	interact	VBG
cord-265941-eff4le0g	186	37	with	with	IN
cord-265941-eff4le0g	186	38	the	the	DT
cord-265941-eff4le0g	186	39	RIPK3	ripk3	NN
cord-265941-eff4le0g	186	40	kinase	kinase	NN
cord-265941-eff4le0g	186	41	domain	domain	NN
cord-265941-eff4le0g	186	42	[	[	-LRB-
cord-265941-eff4le0g	186	43	101	101	CD
cord-265941-eff4le0g	186	44	]	]	-RRB-
cord-265941-eff4le0g	186	45	.	.	.
cord-265941-eff4le0g	187	1	In	in	IN
cord-265941-eff4le0g	187	2	both	both	DT
cord-265941-eff4le0g	187	3	human	human	JJ
cord-265941-eff4le0g	187	4	and	and	CC
cord-265941-eff4le0g	187	5	mouse	mouse	NN
cord-265941-eff4le0g	187	6	epithelial	epithelial	JJ
cord-265941-eff4le0g	187	7	cells	cell	NNS
cord-265941-eff4le0g	187	8	,	,	,
cord-265941-eff4le0g	187	9	vMLKL	vmlkl	NN
cord-265941-eff4le0g	187	10	and	and	CC
cord-265941-eff4le0g	187	11	RIPK3	ripk3	NN
cord-265941-eff4le0g	187	12	bind	bind	VBP
cord-265941-eff4le0g	187	13	via	via	IN
cord-265941-eff4le0g	187	14	a	a	DT
cord-265941-eff4le0g	187	15	pseudokinase	pseudokinase	NN
cord-265941-eff4le0g	187	16	to	to	IN
cord-265941-eff4le0g	187	17	kinase	kinase	NN
cord-265941-eff4le0g	187	18	domain	domain	NN
cord-265941-eff4le0g	187	19	interface	interface	NN
cord-265941-eff4le0g	187	20	,	,	,
cord-265941-eff4le0g	187	21	such	such	JJ
cord-265941-eff4le0g	187	22	that	that	IN
cord-265941-eff4le0g	187	23	it	-PRON-	PRP
cord-265941-eff4le0g	187	24	overlaps	overlap	VBZ
cord-265941-eff4le0g	187	25	the	the	DT
cord-265941-eff4le0g	187	26	site	site	NN
cord-265941-eff4le0g	187	27	typically	typically	RB
cord-265941-eff4le0g	187	28	engaged	engage	VBN
cord-265941-eff4le0g	187	29	by	by	IN
cord-265941-eff4le0g	187	30	cellular	cellular	JJ
cord-265941-eff4le0g	187	31	MLKL	MLKL	NNP
cord-265941-eff4le0g	187	32	.	.	.
cord-265941-eff4le0g	188	1	In	in	IN
cord-265941-eff4le0g	188	2	particular	particular	JJ
cord-265941-eff4le0g	188	3	,	,	,
cord-265941-eff4le0g	188	4	this	this	DT
cord-265941-eff4le0g	188	5	process	process	NN
cord-265941-eff4le0g	188	6	in	in	IN
cord-265941-eff4le0g	188	7	human	human	JJ
cord-265941-eff4le0g	188	8	cells	cell	NNS
cord-265941-eff4le0g	188	9	prevents	prevent	VBZ
cord-265941-eff4le0g	188	10	RIPK1	ripk1	JJ
cord-265941-eff4le0g	188	11	interaction	interaction	NN
cord-265941-eff4le0g	188	12	,	,	,
cord-265941-eff4le0g	188	13	but	but	CC
cord-265941-eff4le0g	188	14	drives	drive	VBZ
cord-265941-eff4le0g	188	15	RIPK3	ripk3	NN
cord-265941-eff4le0g	188	16	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	188	17	despite	despite	IN
cord-265941-eff4le0g	188	18	pharmacological	pharmacological	JJ
cord-265941-eff4le0g	188	19	kinase	kinase	NN
cord-265941-eff4le0g	188	20	inactivation	inactivation	NN
cord-265941-eff4le0g	188	21	of	of	IN
cord-265941-eff4le0g	188	22	both	both	DT
cord-265941-eff4le0g	188	23	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	188	24	and	and	CC
cord-265941-eff4le0g	188	25	RIPK3	ripk3	XX
cord-265941-eff4le0g	188	26	[	[	-LRB-
cord-265941-eff4le0g	188	27	101	101	CD
cord-265941-eff4le0g	188	28	]	]	-RRB-
cord-265941-eff4le0g	188	29	,	,	,
cord-265941-eff4le0g	188	30	which	which	WDT
cord-265941-eff4le0g	188	31	suggests	suggest	VBZ
cord-265941-eff4le0g	188	32	that	that	DT
cord-265941-eff4le0g	188	33	vMLKL	vmlkl	NN
cord-265941-eff4le0g	188	34	alters	alter	VBZ
cord-265941-eff4le0g	188	35	RIPK3	ripk3	NN
cord-265941-eff4le0g	188	36	in	in	IN
cord-265941-eff4le0g	188	37	a	a	DT
cord-265941-eff4le0g	188	38	manner	manner	NN
cord-265941-eff4le0g	188	39	that	that	WDT
cord-265941-eff4le0g	188	40	nulls	null	NNS
cord-265941-eff4le0g	188	41	kinase	kinase	VBZ
cord-265941-eff4le0g	188	42	inhibitor	inhibitor	NN
cord-265941-eff4le0g	188	43	treatment	treatment	NN
cord-265941-eff4le0g	188	44	or	or	CC
cord-265941-eff4le0g	188	45	promotes	promote	VBZ
cord-265941-eff4le0g	188	46	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	188	47	by	by	IN
cord-265941-eff4le0g	188	48	another	another	DT
cord-265941-eff4le0g	188	49	yet	yet	RB
cord-265941-eff4le0g	188	50	unknown	unknown	JJ
cord-265941-eff4le0g	188	51	kinase	kinase	NN
cord-265941-eff4le0g	188	52	.	.	.
cord-265941-eff4le0g	189	1	However	however	RB
cord-265941-eff4le0g	189	2	,	,	,
cord-265941-eff4le0g	189	3	in	in	IN
cord-265941-eff4le0g	189	4	mouse	mouse	NN
cord-265941-eff4le0g	189	5	cells	cell	NNS
cord-265941-eff4le0g	189	6	,	,	,
cord-265941-eff4le0g	189	7	vMLKL	vmlkl	NN
cord-265941-eff4le0g	189	8	inhibits	inhibit	VBZ
cord-265941-eff4le0g	189	9	RIPK3	ripk3	NN
cord-265941-eff4le0g	189	10	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	189	11	,	,	,
cord-265941-eff4le0g	189	12	thus	thus	RB
cord-265941-eff4le0g	189	13	preventing	prevent	VBG
cord-265941-eff4le0g	189	14	RIPK3	ripk3	NN
cord-265941-eff4le0g	189	15	activation	activation	NN
cord-265941-eff4le0g	189	16	and	and	CC
cord-265941-eff4le0g	189	17	subsequent	subsequent	JJ
cord-265941-eff4le0g	189	18	catalytic	catalytic	JJ
cord-265941-eff4le0g	189	19	activity	activity	NN
cord-265941-eff4le0g	189	20	[	[	-LRB-
cord-265941-eff4le0g	189	21	101	101	CD
cord-265941-eff4le0g	189	22	]	]	-RRB-
cord-265941-eff4le0g	189	23	.	.	.
cord-265941-eff4le0g	190	1	Regardless	regardless	RB
cord-265941-eff4le0g	190	2	,	,	,
cord-265941-eff4le0g	190	3	vMLKL	vmlkl	NN
cord-265941-eff4le0g	190	4	is	be	VBZ
cord-265941-eff4le0g	190	5	capable	capable	JJ
cord-265941-eff4le0g	190	6	of	of	IN
cord-265941-eff4le0g	190	7	sequestering	sequester	VBG
cord-265941-eff4le0g	190	8	both	both	CC
cord-265941-eff4le0g	190	9	mouse	mouse	NN
cord-265941-eff4le0g	190	10	and	and	CC
cord-265941-eff4le0g	190	11	human	human	NN
cord-265941-eff4le0g	190	12	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	190	13	upon	upon	IN
cord-265941-eff4le0g	190	14	expression	expression	NN
cord-265941-eff4le0g	190	15	,	,	,
cord-265941-eff4le0g	190	16	which	which	WDT
cord-265941-eff4le0g	190	17	disrupts	disrupt	VBZ
cord-265941-eff4le0g	190	18	downstream	downstream	JJ
cord-265941-eff4le0g	190	19	TNF	TNF	NNP
cord-265941-eff4le0g	190	20	-	-	HYPH
cord-265941-eff4le0g	190	21	induced	induce	VBN
cord-265941-eff4le0g	190	22	necroptosis	necroptosis	NN
cord-265941-eff4le0g	190	23	.	.	.
cord-265941-eff4le0g	191	1	In	in	IN
cord-265941-eff4le0g	191	2	contrast	contrast	NN
cord-265941-eff4le0g	191	3	to	to	IN
cord-265941-eff4le0g	191	4	DNA	dna	NN
cord-265941-eff4le0g	191	5	viruses	virus	NNS
cord-265941-eff4le0g	191	6	,	,	,
cord-265941-eff4le0g	191	7	the	the	DT
cord-265941-eff4le0g	191	8	mechanisms	mechanism	NNS
cord-265941-eff4le0g	191	9	surrounding	surround	VBG
cord-265941-eff4le0g	191	10	manipulation	manipulation	NN
cord-265941-eff4le0g	191	11	of	of	IN
cord-265941-eff4le0g	191	12	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	191	13	by	by	IN
cord-265941-eff4le0g	191	14	RNA	RNA	NNP
cord-265941-eff4le0g	191	15	viruses	virus	NNS
cord-265941-eff4le0g	191	16	are	be	VBP
cord-265941-eff4le0g	191	17	less	less	RBR
cord-265941-eff4le0g	191	18	explored	explore	VBN
cord-265941-eff4le0g	191	19	.	.	.
cord-265941-eff4le0g	192	1	The	the	DT
cord-265941-eff4le0g	192	2	HIV-1-encoded	hiv-1-encoded	JJ
cord-265941-eff4le0g	192	3	PR	PR	NNP
cord-265941-eff4le0g	192	4	,	,	,
cord-265941-eff4le0g	192	5	previously	previously	RB
cord-265941-eff4le0g	192	6	described	describe	VBN
cord-265941-eff4le0g	192	7	to	to	TO
cord-265941-eff4le0g	192	8	inhibit	inhibit	VB
cord-265941-eff4le0g	192	9	NF	nf	NN
cord-265941-eff4le0g	192	10	-	-	HYPH
cord-265941-eff4le0g	192	11	ĸB	ĸb	NN
cord-265941-eff4le0g	192	12	activation	activation	NN
cord-265941-eff4le0g	192	13	,	,	,
cord-265941-eff4le0g	192	14	also	also	RB
cord-265941-eff4le0g	192	15	disrupts	disrupt	VBZ
cord-265941-eff4le0g	192	16	RIPK1-RIPK3	ripk1-ripk3	CD
cord-265941-eff4le0g	192	17	interaction	interaction	NN
cord-265941-eff4le0g	192	18	in	in	IN
cord-265941-eff4le0g	192	19	CD4	CD4	NNP
cord-265941-eff4le0g	192	20	+	+	CC
cord-265941-eff4le0g	192	21	T	T	NNP
cord-265941-eff4le0g	192	22	cells	cell	NNS
cord-265941-eff4le0g	192	23	via	via	IN
cord-265941-eff4le0g	192	24	RIPK1	ripk1	NN
cord-265941-eff4le0g	192	25	cleavage	cleavage	NN
cord-265941-eff4le0g	192	26	[	[	-LRB-
cord-265941-eff4le0g	192	27	102	102	CD
cord-265941-eff4le0g	192	28	]	]	-RRB-
cord-265941-eff4le0g	192	29	.	.	.
cord-265941-eff4le0g	193	1	This	this	DT
cord-265941-eff4le0g	193	2	may	may	MD
cord-265941-eff4le0g	193	3	contribute	contribute	VB
cord-265941-eff4le0g	193	4	to	to	IN
cord-265941-eff4le0g	193	5	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	193	6	suppression	suppression	NN
cord-265941-eff4le0g	193	7	,	,	,
cord-265941-eff4le0g	193	8	but	but	CC
cord-265941-eff4le0g	193	9	no	no	DT
cord-265941-eff4le0g	193	10	study	study	NN
cord-265941-eff4le0g	193	11	has	have	VBZ
cord-265941-eff4le0g	193	12	confirmed	confirm	VBN
cord-265941-eff4le0g	193	13	this	this	DT
cord-265941-eff4le0g	193	14	observation	observation	NN
cord-265941-eff4le0g	193	15	.	.	.
cord-265941-eff4le0g	194	1	Additionally	additionally	RB
cord-265941-eff4le0g	194	2	,	,	,
cord-265941-eff4le0g	194	3	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	194	4	is	be	VBZ
cord-265941-eff4le0g	194	5	implicated	implicate	VBN
cord-265941-eff4le0g	194	6	in	in	IN
cord-265941-eff4le0g	194	7	the	the	DT
cord-265941-eff4le0g	194	8	proliferative	proliferative	JJ
cord-265941-eff4le0g	194	9	defect	defect	NN
cord-265941-eff4le0g	194	10	of	of	IN
cord-265941-eff4le0g	194	11	HIV	HIV	NNP
cord-265941-eff4le0g	194	12	-	-	HYPH
cord-265941-eff4le0g	194	13	specific	specific	JJ
cord-265941-eff4le0g	194	14	CD8	CD8	NNP
cord-265941-eff4le0g	194	15	+	+	CC
cord-265941-eff4le0g	194	16	T	t	NN
cord-265941-eff4le0g	194	17	lymphocytes	lymphocyte	NNS
cord-265941-eff4le0g	194	18	in	in	IN
cord-265941-eff4le0g	194	19	patients	patient	NNS
cord-265941-eff4le0g	194	20	with	with	IN
cord-265941-eff4le0g	194	21	progressive	progressive	JJ
cord-265941-eff4le0g	194	22	infection	infection	NN
cord-265941-eff4le0g	194	23	[	[	-LRB-
cord-265941-eff4le0g	194	24	103	103	CD
cord-265941-eff4le0g	194	25	]	]	-RRB-
cord-265941-eff4le0g	194	26	.	.	.
cord-265941-eff4le0g	195	1	This	this	DT
cord-265941-eff4le0g	195	2	defect	defect	NN
cord-265941-eff4le0g	195	3	is	be	VBZ
cord-265941-eff4le0g	195	4	successfully	successfully	RB
cord-265941-eff4le0g	195	5	reversed	reverse	VBN
cord-265941-eff4le0g	195	6	following	follow	VBG
cord-265941-eff4le0g	195	7	pre	pre	JJ
cord-265941-eff4le0g	195	8	-	-	NN
cord-265941-eff4le0g	195	9	treatment	treatment	NN
cord-265941-eff4le0g	195	10	of	of	IN
cord-265941-eff4le0g	195	11	antigen	antigen	NN
cord-265941-eff4le0g	195	12	-	-	HYPH
cord-265941-eff4le0g	195	13	stimulated	stimulate	VBN
cord-265941-eff4le0g	195	14	CD8	CD8	NNP
cord-265941-eff4le0g	195	15	+	+	CC
cord-265941-eff4le0g	195	16	T	T	NNP
cord-265941-eff4le0g	195	17	cells	cell	NNS
cord-265941-eff4le0g	195	18	with	with	IN
cord-265941-eff4le0g	195	19	necrosis	necrosis	NN
cord-265941-eff4le0g	195	20	inhibitor	inhibitor	NN
cord-265941-eff4le0g	196	1	NecroX-5	NecroX-5	NNP
cord-265941-eff4le0g	196	2	or	or	CC
cord-265941-eff4le0g	196	3	RIPK3	ripk3	NN
cord-265941-eff4le0g	196	4	silencing	silencing	NN
cord-265941-eff4le0g	196	5	.	.	.
cord-265941-eff4le0g	197	1	However	however	RB
cord-265941-eff4le0g	197	2	,	,	,
cord-265941-eff4le0g	197	3	as	as	IN
cord-265941-eff4le0g	197	4	MLKL	MLKL	NNP
cord-265941-eff4le0g	197	5	dependence	dependence	NN
cord-265941-eff4le0g	197	6	was	be	VBD
cord-265941-eff4le0g	197	7	not	not	RB
cord-265941-eff4le0g	197	8	explored	explore	VBN
cord-265941-eff4le0g	197	9	in	in	IN
cord-265941-eff4le0g	197	10	this	this	DT
cord-265941-eff4le0g	197	11	study	study	NN
cord-265941-eff4le0g	197	12	,	,	,
cord-265941-eff4le0g	197	13	it	-PRON-	PRP
cord-265941-eff4le0g	197	14	would	would	MD
cord-265941-eff4le0g	197	15	be	be	VB
cord-265941-eff4le0g	197	16	appropriate	appropriate	JJ
cord-265941-eff4le0g	197	17	to	to	TO
cord-265941-eff4le0g	197	18	address	address	VB
cord-265941-eff4le0g	197	19	this	this	DT
cord-265941-eff4le0g	197	20	in	in	IN
cord-265941-eff4le0g	197	21	further	further	JJ
cord-265941-eff4le0g	197	22	studies	study	NNS
cord-265941-eff4le0g	197	23	targeting	target	VBG
cord-265941-eff4le0g	197	24	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	197	25	for	for	IN
cord-265941-eff4le0g	197	26	HIV	HIV	NNP
cord-265941-eff4le0g	197	27	therapy	therapy	NN
cord-265941-eff4le0g	197	28	.	.	.
cord-265941-eff4le0g	198	1	Coxsackieviruses	Coxsackieviruses	NNP
cord-265941-eff4le0g	198	2	are	be	VBP
cord-265941-eff4le0g	198	3	the	the	DT
cord-265941-eff4le0g	198	4	etiological	etiological	JJ
cord-265941-eff4le0g	198	5	agent	agent	NN
cord-265941-eff4le0g	198	6	of	of	IN
cord-265941-eff4le0g	198	7	hand	hand	NN
cord-265941-eff4le0g	198	8	,	,	,
cord-265941-eff4le0g	198	9	foot	foot	NN
cord-265941-eff4le0g	198	10	and	and	CC
cord-265941-eff4le0g	198	11	mouth	mouth	NN
cord-265941-eff4le0g	198	12	disease	disease	NN
cord-265941-eff4le0g	198	13	[	[	-LRB-
cord-265941-eff4le0g	198	14	104	104	CD
cord-265941-eff4le0g	198	15	]	]	-RRB-
cord-265941-eff4le0g	198	16	.	.	.
cord-265941-eff4le0g	199	1	Coxsackievirus	Coxsackievirus	NNP
cord-265941-eff4le0g	199	2	A6	A6	NNP
cord-265941-eff4le0g	199	3	(	(	-LRB-
cord-265941-eff4le0g	199	4	CA6	CA6	NNP
cord-265941-eff4le0g	199	5	)	)	-RRB-
cord-265941-eff4le0g	199	6	infection	infection	NN
cord-265941-eff4le0g	199	7	of	of	IN
cord-265941-eff4le0g	199	8	human	human	JJ
cord-265941-eff4le0g	199	9	cells	cell	NNS
cord-265941-eff4le0g	199	10	triggers	trigger	VBZ
cord-265941-eff4le0g	199	11	upregulation	upregulation	NN
cord-265941-eff4le0g	199	12	of	of	IN
cord-265941-eff4le0g	199	13	RIPK3	ripk3	NN
cord-265941-eff4le0g	199	14	via	via	IN
cord-265941-eff4le0g	199	15	its	-PRON-	PRP$
cord-265941-eff4le0g	199	16	non	non	JJ
cord-265941-eff4le0g	199	17	-	-	JJ
cord-265941-eff4le0g	199	18	structural	structural	JJ
cord-265941-eff4le0g	199	19	protein	protein	NN
cord-265941-eff4le0g	199	20	(	(	-LRB-
cord-265941-eff4le0g	199	21	Nsp)-3D	Nsp)-3D	NNP
cord-265941-eff4le0g	199	22	,	,	,
cord-265941-eff4le0g	199	23	which	which	WDT
cord-265941-eff4le0g	199	24	increases	increase	VBZ
cord-265941-eff4le0g	199	25	subsequent	subsequent	JJ
cord-265941-eff4le0g	199	26	necrotic	necrotic	JJ
cord-265941-eff4le0g	199	27	death	death	NN
cord-265941-eff4le0g	199	28	[	[	-LRB-
cord-265941-eff4le0g	199	29	105	105	CD
cord-265941-eff4le0g	199	30	]	]	-RRB-
cord-265941-eff4le0g	199	31	.	.	.
cord-265941-eff4le0g	200	1	This	this	DT
cord-265941-eff4le0g	200	2	cell	cell	NN
cord-265941-eff4le0g	200	3	death	death	NN
cord-265941-eff4le0g	200	4	can	can	MD
cord-265941-eff4le0g	200	5	be	be	VB
cord-265941-eff4le0g	200	6	inhibited	inhibit	VBN
cord-265941-eff4le0g	200	7	by	by	IN
cord-265941-eff4le0g	200	8	Nec-1	Nec-1	NNP
cord-265941-eff4le0g	200	9	,	,	,
cord-265941-eff4le0g	200	10	which	which	WDT
cord-265941-eff4le0g	200	11	dramatically	dramatically	RB
cord-265941-eff4le0g	200	12	reduces	reduce	VBZ
cord-265941-eff4le0g	200	13	virus	virus	NN
cord-265941-eff4le0g	200	14	production	production	NN
cord-265941-eff4le0g	200	15	,	,	,
cord-265941-eff4le0g	200	16	suggesting	suggest	VBG
cord-265941-eff4le0g	200	17	that	that	IN
cord-265941-eff4le0g	200	18	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	200	19	is	be	VBZ
cord-265941-eff4le0g	200	20	required	require	VBN
cord-265941-eff4le0g	200	21	for	for	IN
cord-265941-eff4le0g	200	22	CA6	CA6	NNP
cord-265941-eff4le0g	200	23	infection	infection	NN
cord-265941-eff4le0g	200	24	.	.	.
cord-265941-eff4le0g	201	1	It	-PRON-	PRP
cord-265941-eff4le0g	201	2	should	should	MD
cord-265941-eff4le0g	201	3	be	be	VB
cord-265941-eff4le0g	201	4	specified	specify	VBN
cord-265941-eff4le0g	201	5	that	that	IN
cord-265941-eff4le0g	201	6	although	although	IN
cord-265941-eff4le0g	201	7	the	the	DT
cord-265941-eff4le0g	201	8	study	study	NN
cord-265941-eff4le0g	201	9	attributes	attribute	VBZ
cord-265941-eff4le0g	201	10	necroptosis	necroptosis	NN
cord-265941-eff4le0g	201	11	to	to	IN
cord-265941-eff4le0g	201	12	CA6	CA6	NNP
cord-265941-eff4le0g	201	13	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	201	14	,	,	,
cord-265941-eff4le0g	201	15	no	no	DT
cord-265941-eff4le0g	201	16	changes	change	NNS
cord-265941-eff4le0g	201	17	in	in	IN
cord-265941-eff4le0g	201	18	MLKL	MLKL	NNP
cord-265941-eff4le0g	201	19	nor	nor	CC
cord-265941-eff4le0g	201	20	pMLKL	pmlkl	JJ
cord-265941-eff4le0g	201	21	expression	expression	NN
cord-265941-eff4le0g	201	22	was	be	VBD
cord-265941-eff4le0g	201	23	found	find	VBN
cord-265941-eff4le0g	201	24	.	.	.
cord-265941-eff4le0g	202	1	In	in	IN
cord-265941-eff4le0g	202	2	contrast	contrast	NN
cord-265941-eff4le0g	202	3	,	,	,
cord-265941-eff4le0g	202	4	at	at	IN
cord-265941-eff4le0g	202	5	late	late	JJ
cord-265941-eff4le0g	202	6	stages	stage	NNS
cord-265941-eff4le0g	202	7	of	of	IN
cord-265941-eff4le0g	202	8	human	human	JJ
cord-265941-eff4le0g	202	9	intestinal	intestinal	JJ
cord-265941-eff4le0g	202	10	epithelial	epithelial	JJ
cord-265941-eff4le0g	202	11	cell	cell	NN
cord-265941-eff4le0g	202	12	infection	infection	NN
cord-265941-eff4le0g	202	13	with	with	IN
cord-265941-eff4le0g	202	14	coxsackievirus	coxsackievirus	NNP
cord-265941-eff4le0g	202	15	B3	B3	NNP
cord-265941-eff4le0g	202	16	(	(	-LRB-
cord-265941-eff4le0g	202	17	CVB	CVB	NNP
cord-265941-eff4le0g	202	18	)	)	-RRB-
cord-265941-eff4le0g	202	19	,	,	,
cord-265941-eff4le0g	202	20	Nsp-3C	Nsp-3C	NNP
cord-265941-eff4le0g	202	21	(	(	-LRB-
cord-265941-eff4le0g	202	22	3C	3C	NNP
cord-265941-eff4le0g	202	23	pro	pro	NNP
cord-265941-eff4le0g	202	24	)	)	-RRB-
cord-265941-eff4le0g	202	25	proteolytically	proteolytically	RB
cord-265941-eff4le0g	202	26	cleaves	cleave	VBZ
cord-265941-eff4le0g	202	27	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	202	28	and	and	CC
cord-265941-eff4le0g	202	29	disrupts	disrupt	VBZ
cord-265941-eff4le0g	202	30	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	202	31	,	,	,
cord-265941-eff4le0g	202	32	as	as	IN
cord-265941-eff4le0g	202	33	determined	determine	VBN
cord-265941-eff4le0g	202	34	by	by	IN
cord-265941-eff4le0g	202	35	lack	lack	NN
cord-265941-eff4le0g	202	36	of	of	IN
cord-265941-eff4le0g	202	37	HMGB1	HMGB1	NNP
cord-265941-eff4le0g	202	38	release	release	NN
cord-265941-eff4le0g	202	39	[	[	-LRB-
cord-265941-eff4le0g	202	40	37	37	CD
cord-265941-eff4le0g	202	41	]	]	-RRB-
cord-265941-eff4le0g	202	42	.	.	.
cord-265941-eff4le0g	203	1	Intriguingly	intriguingly	RB
cord-265941-eff4le0g	203	2	,	,	,
cord-265941-eff4le0g	203	3	the	the	DT
cord-265941-eff4le0g	203	4	cleaved	cleave	VBN
cord-265941-eff4le0g	203	5	RIPK3	ripk3	NN
cord-265941-eff4le0g	203	6	interacts	interact	VBZ
cord-265941-eff4le0g	203	7	with	with	IN
cord-265941-eff4le0g	203	8	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	203	9	to	to	TO
cord-265941-eff4le0g	203	10	induce	induce	VB
cord-265941-eff4le0g	203	11	a	a	DT
cord-265941-eff4le0g	203	12	non	non	JJ
cord-265941-eff4le0g	203	13	-	-	JJ
cord-265941-eff4le0g	203	14	necrotic	necrotic	JJ
cord-265941-eff4le0g	203	15	death	death	NN
cord-265941-eff4le0g	203	16	[	[	-LRB-
cord-265941-eff4le0g	203	17	37	37	CD
cord-265941-eff4le0g	203	18	]	]	-RRB-
cord-265941-eff4le0g	203	19	,	,	,
cord-265941-eff4le0g	203	20	implying	imply	VBG
cord-265941-eff4le0g	203	21	that	that	IN
cord-265941-eff4le0g	203	22	CVB	CVB	NNP
cord-265941-eff4le0g	203	23	manipulates	manipulate	VBZ
cord-265941-eff4le0g	203	24	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	203	25	to	to	TO
cord-265941-eff4le0g	203	26	redirect	redirect	VB
cord-265941-eff4le0g	203	27	the	the	DT
cord-265941-eff4le0g	203	28	host	host	NN
cord-265941-eff4le0g	203	29	cell	cell	NN
cord-265941-eff4le0g	203	30	into	into	IN
cord-265941-eff4le0g	203	31	a	a	DT
cord-265941-eff4le0g	203	32	more	more	RBR
cord-265941-eff4le0g	203	33	favourable	favourable	JJ
cord-265941-eff4le0g	203	34	but	but	CC
cord-265941-eff4le0g	203	35	yet	yet	CC
cord-265941-eff4le0g	203	36	undefined	undefined	JJ
cord-265941-eff4le0g	203	37	death	death	NN
cord-265941-eff4le0g	203	38	pathway	pathway	NN
cord-265941-eff4le0g	203	39	.	.	.
cord-265941-eff4le0g	204	1	Respiratory	respiratory	JJ
cord-265941-eff4le0g	204	2	syncytial	syncytial	JJ
cord-265941-eff4le0g	204	3	virus	virus	NN
cord-265941-eff4le0g	204	4	(	(	-LRB-
cord-265941-eff4le0g	204	5	RSV	RSV	NNP
cord-265941-eff4le0g	204	6	)	)	-RRB-
cord-265941-eff4le0g	204	7	triggers	trigger	VBZ
cord-265941-eff4le0g	204	8	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	204	9	without	without	IN
cord-265941-eff4le0g	204	10	direct	direct	JJ
cord-265941-eff4le0g	204	11	modulation	modulation	NN
cord-265941-eff4le0g	204	12	of	of	IN
cord-265941-eff4le0g	204	13	RIPK1/3	RIPK1/3	NNP
cord-265941-eff4le0g	204	14	.	.	.
cord-265941-eff4le0g	205	1	RSV	RSV	NNP
cord-265941-eff4le0g	205	2	causes	cause	VBZ
cord-265941-eff4le0g	205	3	bronchiolitis	bronchiolitis	NN
cord-265941-eff4le0g	205	4	in	in	IN
cord-265941-eff4le0g	205	5	children	child	NNS
cord-265941-eff4le0g	205	6	,	,	,
cord-265941-eff4le0g	205	7	typically	typically	RB
cord-265941-eff4le0g	205	8	characterised	characterise	VBN
cord-265941-eff4le0g	205	9	by	by	IN
cord-265941-eff4le0g	205	10	airway	airway	JJ
cord-265941-eff4le0g	205	11	epithelial	epithelial	JJ
cord-265941-eff4le0g	205	12	cell	cell	NN
cord-265941-eff4le0g	205	13	(	(	-LRB-
cord-265941-eff4le0g	205	14	AEC	AEC	NNP
cord-265941-eff4le0g	205	15	)	)	-RRB-
cord-265941-eff4le0g	205	16	death	death	NN
cord-265941-eff4le0g	205	17	and	and	CC
cord-265941-eff4le0g	205	18	massive	massive	JJ
cord-265941-eff4le0g	205	19	cytokine	cytokine	NN
cord-265941-eff4le0g	205	20	release	release	NN
cord-265941-eff4le0g	205	21	[	[	-LRB-
cord-265941-eff4le0g	205	22	106	106	CD
cord-265941-eff4le0g	205	23	]	]	-RRB-
cord-265941-eff4le0g	205	24	.	.	.
cord-265941-eff4le0g	206	1	In	in	IN
cord-265941-eff4le0g	206	2	response	response	NN
cord-265941-eff4le0g	206	3	to	to	IN
cord-265941-eff4le0g	206	4	infection	infection	NN
cord-265941-eff4le0g	206	5	,	,	,
cord-265941-eff4le0g	206	6	primary	primary	JJ
cord-265941-eff4le0g	206	7	human	human	JJ
cord-265941-eff4le0g	206	8	AECs	aec	NNS
cord-265941-eff4le0g	206	9	exhibit	exhibit	NN
cord-265941-eff4le0g	206	10	increased	increase	VBN
cord-265941-eff4le0g	206	11	levels	level	NNS
cord-265941-eff4le0g	206	12	of	of	IN
cord-265941-eff4le0g	206	13	pRIPK1	pRIPK1	NNP
cord-265941-eff4le0g	206	14	,	,	,
cord-265941-eff4le0g	206	15	pMLKL	pMLKL	NNP
cord-265941-eff4le0g	206	16	and	and	CC
cord-265941-eff4le0g	206	17	HMGB1	HMGB1	NNP
cord-265941-eff4le0g	206	18	release	release	NNP
cord-265941-eff4le0g	206	19	,	,	,
cord-265941-eff4le0g	206	20	which	which	WDT
cord-265941-eff4le0g	206	21	correlates	correlate	VBZ
cord-265941-eff4le0g	206	22	with	with	IN
cord-265941-eff4le0g	206	23	increased	increase	VBN
cord-265941-eff4le0g	206	24	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	206	25	death	death	NN
cord-265941-eff4le0g	206	26	[	[	-LRB-
cord-265941-eff4le0g	206	27	107	107	CD
cord-265941-eff4le0g	206	28	]	]	-RRB-
cord-265941-eff4le0g	206	29	.	.	.
cord-265941-eff4le0g	207	1	Pharmacological	pharmacological	JJ
cord-265941-eff4le0g	207	2	inhibition	inhibition	NN
cord-265941-eff4le0g	207	3	of	of	IN
cord-265941-eff4le0g	207	4	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	207	5	and	and	CC
cord-265941-eff4le0g	207	6	MLKL	MLKL	NNP
cord-265941-eff4le0g	207	7	reduces	reduce	VBZ
cord-265941-eff4le0g	207	8	viral	viral	JJ
cord-265941-eff4le0g	207	9	titres	titre	NNS
cord-265941-eff4le0g	207	10	,	,	,
cord-265941-eff4le0g	207	11	suggesting	suggest	VBG
cord-265941-eff4le0g	207	12	that	that	IN
cord-265941-eff4le0g	207	13	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	207	14	promotes	promote	VBZ
cord-265941-eff4le0g	207	15	viral	viral	JJ
cord-265941-eff4le0g	207	16	persistence	persistence	NN
cord-265941-eff4le0g	207	17	.	.	.
cord-265941-eff4le0g	208	1	These	these	DT
cord-265941-eff4le0g	208	2	results	result	NNS
cord-265941-eff4le0g	208	3	are	be	VBP
cord-265941-eff4le0g	208	4	recapitulated	recapitulate	VBN
cord-265941-eff4le0g	208	5	in	in	IN
cord-265941-eff4le0g	208	6	a	a	DT
cord-265941-eff4le0g	208	7	mouse	mouse	NN
cord-265941-eff4le0g	208	8	model	model	NN
cord-265941-eff4le0g	208	9	using	use	VBG
cord-265941-eff4le0g	208	10	pneumonia	pneumonia	NN
cord-265941-eff4le0g	208	11	virus	virus	NN
cord-265941-eff4le0g	208	12	of	of	IN
cord-265941-eff4le0g	208	13	mice	mouse	NNS
cord-265941-eff4le0g	208	14	(	(	-LRB-
cord-265941-eff4le0g	208	15	PVM	PVM	NNP
cord-265941-eff4le0g	208	16	)	)	-RRB-
cord-265941-eff4le0g	208	17	.	.	.
cord-265941-eff4le0g	209	1	Here	here	RB
cord-265941-eff4le0g	209	2	,	,	,
cord-265941-eff4le0g	209	3	inhibition	inhibition	NN
cord-265941-eff4le0g	209	4	of	of	IN
cord-265941-eff4le0g	209	5	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	209	6	or	or	CC
cord-265941-eff4le0g	209	7	MLKL	MLKL	NNP
cord-265941-eff4le0g	209	8	lowered	lower	VBD
cord-265941-eff4le0g	209	9	viral	viral	JJ
cord-265941-eff4le0g	209	10	loads	load	NNS
cord-265941-eff4le0g	209	11	and	and	CC
cord-265941-eff4le0g	209	12	prevented	prevent	VBD
cord-265941-eff4le0g	209	13	severe	severe	JJ
cord-265941-eff4le0g	209	14	bronchiolitis	bronchiolitis	NN
cord-265941-eff4le0g	209	15	,	,	,
cord-265941-eff4le0g	209	16	also	also	RB
cord-265941-eff4le0g	209	17	seen	see	VBN
cord-265941-eff4le0g	209	18	in	in	IN
cord-265941-eff4le0g	209	19	Ripk1	ripk1	JJ
cord-265941-eff4le0g	209	20	K45A	K45A	NNP
cord-265941-eff4le0g	209	21	/	/	SYM
cord-265941-eff4le0g	209	22	K45A	K45A	NNP
cord-265941-eff4le0g	209	23	mice	mouse	NNS
cord-265941-eff4le0g	209	24	[	[	-LRB-
cord-265941-eff4le0g	209	25	107	107	CD
cord-265941-eff4le0g	209	26	]	]	-RRB-
cord-265941-eff4le0g	209	27	.	.	.
cord-265941-eff4le0g	210	1	The	the	DT
cord-265941-eff4le0g	210	2	necrosome	necrosome	NN
cord-265941-eff4le0g	210	3	is	be	VBZ
cord-265941-eff4le0g	210	4	also	also	RB
cord-265941-eff4le0g	210	5	reported	report	VBN
cord-265941-eff4le0g	210	6	to	to	TO
cord-265941-eff4le0g	210	7	trigger	trigger	VB
cord-265941-eff4le0g	210	8	neutrophil	neutrophil	NN
cord-265941-eff4le0g	210	9	extracellular	extracellular	JJ
cord-265941-eff4le0g	210	10	traps	trap	NNS
cord-265941-eff4le0g	210	11	(	(	-LRB-
cord-265941-eff4le0g	210	12	NET	net	NN
cord-265941-eff4le0g	210	13	)	)	-RRB-
cord-265941-eff4le0g	210	14	release	release	NN
cord-265941-eff4le0g	210	15	in	in	IN
cord-265941-eff4le0g	210	16	RSV	RSV	NNP
cord-265941-eff4le0g	210	17	-	-	HYPH
cord-265941-eff4le0g	210	18	stimulated	stimulate	VBN
cord-265941-eff4le0g	210	19	human	human	JJ
cord-265941-eff4le0g	210	20	neutrophils	neutrophil	NNS
cord-265941-eff4le0g	210	21	or	or	CC
cord-265941-eff4le0g	210	22	neutrophils	neutrophil	NNS
cord-265941-eff4le0g	210	23	co	co	VBP
cord-265941-eff4le0g	210	24	-	-	VBD
cord-265941-eff4le0g	210	25	incubated	incubate	VBN
cord-265941-eff4le0g	210	26	with	with	IN
cord-265941-eff4le0g	210	27	RSV	RSV	NNP
cord-265941-eff4le0g	210	28	-	-	HYPH
cord-265941-eff4le0g	210	29	infected	infect	VBN
cord-265941-eff4le0g	210	30	AECs	aec	NNS
cord-265941-eff4le0g	210	31	[	[	-LRB-
cord-265941-eff4le0g	210	32	108	108	CD
cord-265941-eff4le0g	210	33	]	]	-RRB-
cord-265941-eff4le0g	210	34	,	,	,
cord-265941-eff4le0g	210	35	which	which	WDT
cord-265941-eff4le0g	210	36	facilitates	facilitate	VBZ
cord-265941-eff4le0g	210	37	RSV	RSV	NNP
cord-265941-eff4le0g	210	38	containment	containment	NN
cord-265941-eff4le0g	210	39	.	.	.
cord-265941-eff4le0g	211	1	The	the	DT
cord-265941-eff4le0g	211	2	topic	topic	NN
cord-265941-eff4le0g	211	3	of	of	IN
cord-265941-eff4le0g	211	4	viral	viral	JJ
cord-265941-eff4le0g	211	5	respiratory	respiratory	JJ
cord-265941-eff4le0g	211	6	illness	illness	NN
cord-265941-eff4le0g	211	7	has	have	VBZ
cord-265941-eff4le0g	211	8	gained	gain	VBN
cord-265941-eff4le0g	211	9	much	much	JJ
cord-265941-eff4le0g	211	10	attention	attention	NN
cord-265941-eff4le0g	211	11	recently	recently	RB
cord-265941-eff4le0g	211	12	due	due	JJ
cord-265941-eff4le0g	211	13	to	to	IN
cord-265941-eff4le0g	211	14	the	the	DT
cord-265941-eff4le0g	211	15	emergence	emergence	NN
cord-265941-eff4le0g	211	16	of	of	IN
cord-265941-eff4le0g	211	17	the	the	DT
cord-265941-eff4le0g	211	18	hypervirulent	hypervirulent	NN
cord-265941-eff4le0g	211	19	severe	severe	JJ
cord-265941-eff4le0g	211	20	acute	acute	JJ
cord-265941-eff4le0g	211	21	respiratory	respiratory	JJ
cord-265941-eff4le0g	211	22	syndrome	syndrome	NN
cord-265941-eff4le0g	211	23	coronavirus	coronavirus	NN
cord-265941-eff4le0g	211	24	2	2	CD
cord-265941-eff4le0g	211	25	(	(	-LRB-
cord-265941-eff4le0g	211	26	SARS	SARS	NNP
cord-265941-eff4le0g	211	27	-	-	HYPH
cord-265941-eff4le0g	211	28	CoV-2	CoV-2	NNP
cord-265941-eff4le0g	211	29	)	)	-RRB-
cord-265941-eff4le0g	211	30	responsible	responsible	JJ
cord-265941-eff4le0g	211	31	for	for	IN
cord-265941-eff4le0g	211	32	COVID-	covid-	NN
cord-265941-eff4le0g	211	33	19	19	CD
cord-265941-eff4le0g	211	34	.	.	.
cord-265941-eff4le0g	212	1	In	in	IN
cord-265941-eff4le0g	212	2	an	an	DT
cord-265941-eff4le0g	212	3	effort	effort	NN
cord-265941-eff4le0g	212	4	to	to	TO
cord-265941-eff4le0g	212	5	identify	identify	VB
cord-265941-eff4le0g	212	6	potential	potential	JJ
cord-265941-eff4le0g	212	7	therapeutic	therapeutic	JJ
cord-265941-eff4le0g	212	8	targets	target	NNS
cord-265941-eff4le0g	212	9	,	,	,
cord-265941-eff4le0g	212	10	Gordon	Gordon	NNP
cord-265941-eff4le0g	212	11	et	et	NNP
cord-265941-eff4le0g	212	12	al	al	NNP
cord-265941-eff4le0g	212	13	.	.	.
cord-265941-eff4le0g	213	1	[	[	-LRB-
cord-265941-eff4le0g	213	2	109	109	CD
cord-265941-eff4le0g	213	3	]	]	-RRB-
cord-265941-eff4le0g	213	4	have	have	VBP
cord-265941-eff4le0g	213	5	mapped	map	VBN
cord-265941-eff4le0g	213	6	the	the	DT
cord-265941-eff4le0g	213	7	interactions	interaction	NNS
cord-265941-eff4le0g	213	8	between	between	IN
cord-265941-eff4le0g	213	9	SARS	SARS	NNP
cord-265941-eff4le0g	213	10	-	-	HYPH
cord-265941-eff4le0g	213	11	CoV-2	CoV-2	NNP
cord-265941-eff4le0g	213	12	proteins	protein	NNS
cord-265941-eff4le0g	213	13	and	and	CC
cord-265941-eff4le0g	213	14	human	human	JJ
cord-265941-eff4le0g	213	15	proteins	protein	NNS
cord-265941-eff4le0g	213	16	.	.	.
cord-265941-eff4le0g	214	1	Amidst	amidst	IN
cord-265941-eff4le0g	214	2	the	the	DT
cord-265941-eff4le0g	214	3	phenomenal	phenomenal	JJ
cord-265941-eff4le0g	214	4	set	set	NN
cord-265941-eff4le0g	214	5	of	of	IN
cord-265941-eff4le0g	214	6	results	result	NNS
cord-265941-eff4le0g	214	7	,	,	,
cord-265941-eff4le0g	214	8	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	214	9	was	be	VBD
cord-265941-eff4le0g	214	10	shown	show	VBN
cord-265941-eff4le0g	214	11	to	to	TO
cord-265941-eff4le0g	214	12	associate	associate	VB
cord-265941-eff4le0g	214	13	with	with	IN
cord-265941-eff4le0g	214	14	the	the	DT
cord-265941-eff4le0g	214	15	viral	viral	JJ
cord-265941-eff4le0g	214	16	Nsp-12	Nsp-12	NNP
cord-265941-eff4le0g	214	17	,	,	,
cord-265941-eff4le0g	214	18	which	which	WDT
cord-265941-eff4le0g	214	19	is	be	VBZ
cord-265941-eff4le0g	214	20	inferred	infer	VBN
cord-265941-eff4le0g	214	21	to	to	TO
cord-265941-eff4le0g	214	22	be	be	VB
cord-265941-eff4le0g	214	23	an	an	DT
cord-265941-eff4le0g	214	24	RNA	RNA	NNP
cord-265941-eff4le0g	214	25	polymerase	polymerase	NN
cord-265941-eff4le0g	214	26	.	.	.
cord-265941-eff4le0g	215	1	Perhaps	perhaps	RB
cord-265941-eff4le0g	215	2	unsurprisingly	unsurprisingly	RB
cord-265941-eff4le0g	215	3	,	,	,
cord-265941-eff4le0g	215	4	the	the	DT
cord-265941-eff4le0g	215	5	2002	2002	CD
cord-265941-eff4le0g	215	6	SARS	SARS	NNP
cord-265941-eff4le0g	215	7	-	-	HYPH
cord-265941-eff4le0g	215	8	CoV	CoV	NNP
cord-265941-eff4le0g	215	9	has	have	VBZ
cord-265941-eff4le0g	215	10	been	be	VBN
cord-265941-eff4le0g	215	11	shown	show	VBN
cord-265941-eff4le0g	215	12	to	to	TO
cord-265941-eff4le0g	215	13	interact	interact	VB
cord-265941-eff4le0g	215	14	with	with	IN
cord-265941-eff4le0g	215	15	RIPK3	ripk3	NN
cord-265941-eff4le0g	215	16	via	via	IN
cord-265941-eff4le0g	215	17	its	-PRON-	PRP$
cord-265941-eff4le0g	215	18	open	open	JJ
cord-265941-eff4le0g	215	19	reading	reading	NN
cord-265941-eff4le0g	215	20	frame	frame	NN
cord-265941-eff4le0g	215	21	(	(	-LRB-
cord-265941-eff4le0g	215	22	ORF)-3a	orf)-3a	JJ
cord-265941-eff4le0g	215	23	protein	protein	NN
cord-265941-eff4le0g	215	24	(	(	-LRB-
cord-265941-eff4le0g	215	25	SARS	SARS	NNP
cord-265941-eff4le0g	215	26	3a	3a	NNP
cord-265941-eff4le0g	215	27	)	)	-RRB-
cord-265941-eff4le0g	215	28	to	to	TO
cord-265941-eff4le0g	215	29	promote	promote	VB
cord-265941-eff4le0g	215	30	SARS	SARS	NNP
cord-265941-eff4le0g	215	31	3a	3a	NNP
cord-265941-eff4le0g	215	32	oligomerization	oligomerization	NN
cord-265941-eff4le0g	215	33	and	and	CC
cord-265941-eff4le0g	215	34	subsequent	subsequent	JJ
cord-265941-eff4le0g	215	35	necrotic	necrotic	JJ
cord-265941-eff4le0g	215	36	death	death	NN
cord-265941-eff4le0g	215	37	in	in	IN
cord-265941-eff4le0g	215	38	human	human	JJ
cord-265941-eff4le0g	215	39	lung	lung	NN
cord-265941-eff4le0g	215	40	cells	cell	NNS
cord-265941-eff4le0g	215	41	[	[	-LRB-
cord-265941-eff4le0g	215	42	110	110	CD
cord-265941-eff4le0g	215	43	]	]	-RRB-
cord-265941-eff4le0g	215	44	.	.	.
cord-265941-eff4le0g	216	1	This	this	DT
cord-265941-eff4le0g	216	2	process	process	NN
cord-265941-eff4le0g	216	3	operates	operate	VBZ
cord-265941-eff4le0g	216	4	independently	independently	RB
cord-265941-eff4le0g	216	5	of	of	IN
cord-265941-eff4le0g	216	6	RIPK3	ripk3	NN
cord-265941-eff4le0g	216	7	kinase	kinase	NN
cord-265941-eff4le0g	216	8	activity	activity	NN
cord-265941-eff4le0g	216	9	and	and	CC
cord-265941-eff4le0g	216	10	MLKL	MLKL	NNP
cord-265941-eff4le0g	216	11	[	[	-LRB-
cord-265941-eff4le0g	216	12	110	110	CD
cord-265941-eff4le0g	216	13	]	]	-RRB-
cord-265941-eff4le0g	216	14	,	,	,
cord-265941-eff4le0g	216	15	with	with	IN
cord-265941-eff4le0g	216	16	SARS	SARS	NNP
cord-265941-eff4le0g	216	17	3a	3a	CD
cord-265941-eff4le0g	216	18	likely	likely	RB
cord-265941-eff4le0g	216	19	replacing	replace	VBG
cord-265941-eff4le0g	216	20	the	the	DT
cord-265941-eff4le0g	216	21	latter	latter	JJ
cord-265941-eff4le0g	216	22	as	as	IN
cord-265941-eff4le0g	216	23	the	the	DT
cord-265941-eff4le0g	216	24	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	216	25	executioner	executioner	NN
cord-265941-eff4le0g	216	26	due	due	IN
cord-265941-eff4le0g	216	27	to	to	IN
cord-265941-eff4le0g	216	28	its	-PRON-	PRP$
cord-265941-eff4le0g	216	29	ability	ability	NN
cord-265941-eff4le0g	216	30	to	to	TO
cord-265941-eff4le0g	216	31	function	function	VB
cord-265941-eff4le0g	216	32	as	as	IN
cord-265941-eff4le0g	216	33	an	an	DT
cord-265941-eff4le0g	216	34	ion	ion	NN
cord-265941-eff4le0g	216	35	channel	channel	NN
cord-265941-eff4le0g	216	36	following	follow	VBG
cord-265941-eff4le0g	216	37	membrane	membrane	NN
cord-265941-eff4le0g	216	38	insertion	insertion	NN
cord-265941-eff4le0g	216	39	[	[	-LRB-
cord-265941-eff4le0g	216	40	111	111	CD
cord-265941-eff4le0g	216	41	]	]	-RRB-
cord-265941-eff4le0g	216	42	.	.	.
cord-265941-eff4le0g	217	1	However	however	RB
cord-265941-eff4le0g	217	2	,	,	,
cord-265941-eff4le0g	217	3	SARS	SARS	NNP
cord-265941-eff4le0g	217	4	3a	3a	NNP
cord-265941-eff4le0g	217	5	also	also	RB
cord-265941-eff4le0g	217	6	reduces	reduce	VBZ
cord-265941-eff4le0g	217	7	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	217	8	and	and	CC
cord-265941-eff4le0g	217	9	MLKL	MLKL	NNP
cord-265941-eff4le0g	217	10	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	217	11	[	[	-LRB-
cord-265941-eff4le0g	217	12	110	110	CD
cord-265941-eff4le0g	217	13	]	]	-RRB-
cord-265941-eff4le0g	217	14	.	.	.
cord-265941-eff4le0g	218	1	Infection	infection	NN
cord-265941-eff4le0g	218	2	with	with	IN
cord-265941-eff4le0g	218	3	a	a	DT
cord-265941-eff4le0g	218	4	SARS	SARS	NNP
cord-265941-eff4le0g	218	5	3a	3a	NN
cord-265941-eff4le0g	218	6	-	-	HYPH
cord-265941-eff4le0g	218	7	deletion	deletion	NN
cord-265941-eff4le0g	218	8	mutant	mutant	JJ
cord-265941-eff4le0g	218	9	rescued	rescue	VBD
cord-265941-eff4le0g	218	10	mice	mouse	NNS
cord-265941-eff4le0g	218	11	from	from	IN
cord-265941-eff4le0g	218	12	virus	virus	NN
cord-265941-eff4le0g	218	13	-	-	HYPH
cord-265941-eff4le0g	218	14	induced	induce	VBN
cord-265941-eff4le0g	218	15	mortality	mortality	NN
cord-265941-eff4le0g	218	16	,	,	,
cord-265941-eff4le0g	218	17	suggesting	suggest	VBG
cord-265941-eff4le0g	218	18	an	an	DT
cord-265941-eff4le0g	218	19	antiviral	antiviral	JJ
cord-265941-eff4le0g	218	20	role	role	NN
cord-265941-eff4le0g	218	21	for	for	IN
cord-265941-eff4le0g	218	22	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	218	23	in	in	IN
cord-265941-eff4le0g	218	24	SARS	SARS	NNP
cord-265941-eff4le0g	218	25	-	-	HYPH
cord-265941-eff4le0g	218	26	CoV	CoV	NNP
cord-265941-eff4le0g	218	27	infection	infection	NN
cord-265941-eff4le0g	218	28	[	[	-LRB-
cord-265941-eff4le0g	218	29	112	112	CD
cord-265941-eff4le0g	218	30	]	]	-RRB-
cord-265941-eff4le0g	218	31	.	.	.
cord-265941-eff4le0g	219	1	Compared	compare	VBN
cord-265941-eff4le0g	219	2	to	to	IN
cord-265941-eff4le0g	219	3	viral	viral	JJ
cord-265941-eff4le0g	219	4	pathogens	pathogen	NNS
cord-265941-eff4le0g	219	5	,	,	,
cord-265941-eff4le0g	219	6	far	far	RB
cord-265941-eff4le0g	219	7	fewer	few	JJR
cord-265941-eff4le0g	219	8	bacterial	bacterial	JJ
cord-265941-eff4le0g	219	9	effectors	effector	NNS
cord-265941-eff4le0g	219	10	have	have	VBP
cord-265941-eff4le0g	219	11	been	be	VBN
cord-265941-eff4le0g	219	12	identified	identify	VBN
cord-265941-eff4le0g	219	13	to	to	TO
cord-265941-eff4le0g	219	14	directly	directly	RB
cord-265941-eff4le0g	219	15	interact	interact	VB
cord-265941-eff4le0g	219	16	with	with	IN
cord-265941-eff4le0g	219	17	RIPKs	ripk	NNS
cord-265941-eff4le0g	219	18	for	for	IN
cord-265941-eff4le0g	219	19	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	219	20	modulation	modulation	NN
cord-265941-eff4le0g	219	21	.	.	.
cord-265941-eff4le0g	220	1	EPEC	EPEC	NNP
cord-265941-eff4le0g	220	2	employs	employ	VBZ
cord-265941-eff4le0g	220	3	a	a	DT
cord-265941-eff4le0g	220	4	cysteine	cysteine	NN
cord-265941-eff4le0g	220	5	protease	protease	NN
cord-265941-eff4le0g	220	6	,	,	,
cord-265941-eff4le0g	220	7	EspL	EspL	NNP
cord-265941-eff4le0g	220	8	,	,	,
cord-265941-eff4le0g	220	9	that	that	IN
cord-265941-eff4le0g	220	10	directly	directly	RB
cord-265941-eff4le0g	220	11	cleaves	cleave	VBZ
cord-265941-eff4le0g	220	12	the	the	DT
cord-265941-eff4le0g	220	13	RHIM	RHIM	NNP
cord-265941-eff4le0g	220	14	domain	domain	NN
cord-265941-eff4le0g	220	15	of	of	IN
cord-265941-eff4le0g	220	16	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	220	17	and	and	CC
cord-265941-eff4le0g	220	18	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	220	19	,	,	,
cord-265941-eff4le0g	220	20	which	which	WDT
cord-265941-eff4le0g	220	21	prevents	prevent	VBZ
cord-265941-eff4le0g	220	22	MLKL	MLKL	NNP
cord-265941-eff4le0g	220	23	membrane	membrane	NN
cord-265941-eff4le0g	220	24	complex	complex	JJ
cord-265941-eff4le0g	220	25	formation	formation	NN
cord-265941-eff4le0g	220	26	during	during	IN
cord-265941-eff4le0g	220	27	infection	infection	NN
cord-265941-eff4le0g	220	28	[	[	-LRB-
cord-265941-eff4le0g	220	29	113	113	CD
cord-265941-eff4le0g	220	30	]	]	-RRB-
cord-265941-eff4le0g	220	31	.	.	.
cord-265941-eff4le0g	221	1	This	this	DT
cord-265941-eff4le0g	221	2	inhibits	inhibit	VBZ
cord-265941-eff4le0g	221	3	TNF	TNF	NNP
cord-265941-eff4le0g	221	4	and	and	CC
cord-265941-eff4le0g	221	5	TLR3/4-induced	TLR3/4-induced	NNP
cord-265941-eff4le0g	221	6	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	221	7	in	in	IN
cord-265941-eff4le0g	221	8	vitro	vitro	FW
cord-265941-eff4le0g	221	9	.	.	.
cord-265941-eff4le0g	222	1	Furthermore	furthermore	RB
cord-265941-eff4le0g	222	2	,	,	,
cord-265941-eff4le0g	222	3	mice	mouse	NNS
cord-265941-eff4le0g	222	4	orally	orally	RB
cord-265941-eff4le0g	222	5	challenged	challenge	VBD
cord-265941-eff4le0g	222	6	with	with	IN
cord-265941-eff4le0g	222	7	an	an	DT
cord-265941-eff4le0g	222	8	espL	espl	JJ
cord-265941-eff4le0g	222	9	deletion	deletion	NN
cord-265941-eff4le0g	222	10	mutant	mutant	NN
cord-265941-eff4le0g	222	11	of	of	IN
cord-265941-eff4le0g	222	12	the	the	DT
cord-265941-eff4le0g	222	13	EPEC	EPEC	NNP
cord-265941-eff4le0g	222	14	-	-	HYPH
cord-265941-eff4le0g	222	15	like	like	JJ
cord-265941-eff4le0g	222	16	mouse	mouse	NN
cord-265941-eff4le0g	222	17	pathogen	pathogen	NN
cord-265941-eff4le0g	222	18	,	,	,
cord-265941-eff4le0g	222	19	Citrobacter	Citrobacter	NNP
cord-265941-eff4le0g	222	20	rodentium	rodentium	NN
cord-265941-eff4le0g	222	21	,	,	,
cord-265941-eff4le0g	222	22	exhibit	exhibit	VB
cord-265941-eff4le0g	222	23	attenuated	attenuated	JJ
cord-265941-eff4le0g	222	24	bacterial	bacterial	JJ
cord-265941-eff4le0g	222	25	colonization	colonization	NN
cord-265941-eff4le0g	222	26	in	in	IN
cord-265941-eff4le0g	222	27	the	the	DT
cord-265941-eff4le0g	222	28	intestine	intestine	NN
cord-265941-eff4le0g	222	29	[	[	-LRB-
cord-265941-eff4le0g	222	30	113	113	CD
cord-265941-eff4le0g	222	31	]	]	-RRB-
cord-265941-eff4le0g	222	32	.	.	.
cord-265941-eff4le0g	223	1	This	this	DT
cord-265941-eff4le0g	223	2	suggests	suggest	VBZ
cord-265941-eff4le0g	223	3	that	that	IN
cord-265941-eff4le0g	223	4	EspL	EspL	NNP
cord-265941-eff4le0g	223	5	-	-	HYPH
cord-265941-eff4le0g	223	6	mediated	mediate	VBN
cord-265941-eff4le0g	223	7	blockade	blockade	NN
cord-265941-eff4le0g	223	8	of	of	IN
cord-265941-eff4le0g	223	9	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	223	10	contributes	contribute	VBZ
cord-265941-eff4le0g	223	11	to	to	IN
cord-265941-eff4le0g	223	12	bacterial	bacterial	JJ
cord-265941-eff4le0g	223	13	persistence	persistence	NN
cord-265941-eff4le0g	223	14	.	.	.
cord-265941-eff4le0g	224	1	Staphylococcus	Staphylococcus	NNP
cord-265941-eff4le0g	224	2	aureus	aureus	NN
cord-265941-eff4le0g	224	3	is	be	VBZ
cord-265941-eff4le0g	224	4	an	an	DT
cord-265941-eff4le0g	224	5	opportunistic	opportunistic	JJ
cord-265941-eff4le0g	224	6	pathogen	pathogen	NN
cord-265941-eff4le0g	224	7	that	that	WDT
cord-265941-eff4le0g	224	8	causes	cause	VBZ
cord-265941-eff4le0g	224	9	pneumonia	pneumonia	NN
cord-265941-eff4le0g	224	10	and	and	CC
cord-265941-eff4le0g	224	11	bacteraemia	bacteraemia	NN
cord-265941-eff4le0g	224	12	in	in	IN
cord-265941-eff4le0g	224	13	immunosuppressed	immunosuppressed	JJ
cord-265941-eff4le0g	224	14	patients	patient	NNS
cord-265941-eff4le0g	224	15	.	.	.
cord-265941-eff4le0g	225	1	Its	-PRON-	PRP$
cord-265941-eff4le0g	225	2	poreforming	poreforme	VBG
cord-265941-eff4le0g	225	3	toxin	toxin	NN
cord-265941-eff4le0g	225	4	(	(	-LRB-
cord-265941-eff4le0g	225	5	PFT	PFT	NNP
cord-265941-eff4le0g	225	6	)	)	-RRB-
cord-265941-eff4le0g	225	7	induces	induce	VBZ
cord-265941-eff4le0g	225	8	necroptosis	necroptosis	NN
cord-265941-eff4le0g	225	9	in	in	IN
cord-265941-eff4le0g	225	10	both	both	CC
cord-265941-eff4le0g	225	11	human	human	JJ
cord-265941-eff4le0g	225	12	and	and	CC
cord-265941-eff4le0g	225	13	murine	murine	JJ
cord-265941-eff4le0g	225	14	pulmonary	pulmonary	JJ
cord-265941-eff4le0g	225	15	macrophages	macrophage	NNS
cord-265941-eff4le0g	225	16	,	,	,
cord-265941-eff4le0g	225	17	and	and	CC
cord-265941-eff4le0g	225	18	as	as	RB
cord-265941-eff4le0g	225	19	such	such	JJ
cord-265941-eff4le0g	225	20	,	,	,
cord-265941-eff4le0g	225	21	inhibition	inhibition	NN
cord-265941-eff4le0g	225	22	of	of	IN
cord-265941-eff4le0g	225	23	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	225	24	or	or	CC
cord-265941-eff4le0g	225	25	MLKL	MLKL	NNP
cord-265941-eff4le0g	225	26	in	in	IN
cord-265941-eff4le0g	225	27	vitro	vitro	FW
cord-265941-eff4le0g	225	28	,	,	,
cord-265941-eff4le0g	225	29	or	or	CC
cord-265941-eff4le0g	225	30	genetic	genetic	JJ
cord-265941-eff4le0g	225	31	deletion	deletion	NN
cord-265941-eff4le0g	225	32	of	of	IN
cord-265941-eff4le0g	225	33	RIPK3	ripk3	NN
cord-265941-eff4le0g	225	34	in	in	IN
cord-265941-eff4le0g	225	35	vivo	vivo	NN
cord-265941-eff4le0g	225	36	,	,	,
cord-265941-eff4le0g	225	37	significantly	significantly	RB
cord-265941-eff4le0g	225	38	reduces	reduce	VBZ
cord-265941-eff4le0g	225	39	cytotoxicity	cytotoxicity	NN
cord-265941-eff4le0g	225	40	and	and	CC
cord-265941-eff4le0g	225	41	improves	improve	VBZ
cord-265941-eff4le0g	225	42	S.	S.	NNP
cord-265941-eff4le0g	225	43	aureus	aureus	NN
cord-265941-eff4le0g	225	44	clearance	clearance	NN
cord-265941-eff4le0g	225	45	in	in	IN
cord-265941-eff4le0g	225	46	the	the	DT
cord-265941-eff4le0g	225	47	lungs	lung	NNS
cord-265941-eff4le0g	225	48	[	[	-LRB-
cord-265941-eff4le0g	225	49	114	114	CD
cord-265941-eff4le0g	225	50	]	]	-RRB-
cord-265941-eff4le0g	225	51	.	.	.
cord-265941-eff4le0g	226	1	Other	other	JJ
cord-265941-eff4le0g	226	2	PFT	PFT	NNP
cord-265941-eff4le0g	226	3	-	-	HYPH
cord-265941-eff4le0g	226	4	carrying	carry	VBG
cord-265941-eff4le0g	226	5	bacterial	bacterial	JJ
cord-265941-eff4le0g	226	6	pathogens	pathogen	NNS
cord-265941-eff4le0g	226	7	,	,	,
cord-265941-eff4le0g	226	8	such	such	JJ
cord-265941-eff4le0g	226	9	as	as	IN
cord-265941-eff4le0g	226	10	Serratia	Serratia	NNP
cord-265941-eff4le0g	226	11	marcescens	marcescen	NNS
cord-265941-eff4le0g	226	12	,	,	,
cord-265941-eff4le0g	226	13	Streptococcus	streptococcus	NN
cord-265941-eff4le0g	226	14	pneumoniae	pneumoniae	NN
cord-265941-eff4le0g	226	15	,	,	,
cord-265941-eff4le0g	226	16	Listeria	Listeria	NNP
cord-265941-eff4le0g	226	17	monocytogenes	monocytogene	NNS
cord-265941-eff4le0g	226	18	and	and	CC
cord-265941-eff4le0g	226	19	uropathogenic	uropathogenic	JJ
cord-265941-eff4le0g	226	20	E.	E.	NNP
cord-265941-eff4le0g	226	21	coli	coli	NNS
cord-265941-eff4le0g	226	22	(	(	-LRB-
cord-265941-eff4le0g	226	23	UPEC	UPEC	NNP
cord-265941-eff4le0g	226	24	)	)	-RRB-
cord-265941-eff4le0g	226	25	also	also	RB
cord-265941-eff4le0g	226	26	trigger	trigger	NN
cord-265941-eff4le0g	226	27	RIPK1/	RIPK1/	.
cord-265941-eff4le0g	227	1	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	228	1	/MLKL	/MLKL	:
cord-265941-eff4le0g	228	2	-	-	HYPH
cord-265941-eff4le0g	228	3	dependent	dependent	JJ
cord-265941-eff4le0g	228	4	necroptosis	necroptosis	NN
cord-265941-eff4le0g	228	5	in	in	IN
cord-265941-eff4le0g	228	6	macrophages	macrophage	NNS
cord-265941-eff4le0g	228	7	,	,	,
cord-265941-eff4le0g	228	8	highlighting	highlight	VBG
cord-265941-eff4le0g	228	9	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	228	10	as	as	IN
cord-265941-eff4le0g	228	11	a	a	DT
cord-265941-eff4le0g	228	12	promising	promising	JJ
cord-265941-eff4le0g	228	13	target	target	NN
cord-265941-eff4le0g	228	14	for	for	IN
cord-265941-eff4le0g	228	15	PFT	pft	NN
cord-265941-eff4le0g	228	16	-	-	HYPH
cord-265941-eff4le0g	228	17	associated	associate	VBN
cord-265941-eff4le0g	228	18	disease	disease	NN
cord-265941-eff4le0g	228	19	intervention	intervention	NN
cord-265941-eff4le0g	228	20	[	[	-LRB-
cord-265941-eff4le0g	228	21	115	115	CD
cord-265941-eff4le0g	228	22	]	]	-RRB-
cord-265941-eff4le0g	228	23	.	.	.
cord-265941-eff4le0g	229	1	In	in	IN
cord-265941-eff4le0g	229	2	contrast	contrast	NN
cord-265941-eff4le0g	229	3	,	,	,
cord-265941-eff4le0g	229	4	in	in	IN
cord-265941-eff4le0g	229	5	models	model	NNS
cord-265941-eff4le0g	229	6	of	of	IN
cord-265941-eff4le0g	229	7	skin	skin	NN
cord-265941-eff4le0g	229	8	infection	infection	NN
cord-265941-eff4le0g	229	9	or	or	CC
cord-265941-eff4le0g	229	10	sepsis	sepsis	NN
cord-265941-eff4le0g	229	11	,	,	,
cord-265941-eff4le0g	229	12	inhibition	inhibition	NN
cord-265941-eff4le0g	229	13	of	of	IN
cord-265941-eff4le0g	229	14	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	229	15	or	or	CC
cord-265941-eff4le0g	229	16	MLKL	MLKL	NNP
cord-265941-eff4le0g	229	17	results	result	NNS
cord-265941-eff4le0g	229	18	in	in	IN
cord-265941-eff4le0g	229	19	exacerbated	exacerbate	VBN
cord-265941-eff4le0g	229	20	disease	disease	NN
cord-265941-eff4le0g	229	21	,	,	,
cord-265941-eff4le0g	229	22	due	due	IN
cord-265941-eff4le0g	229	23	to	to	IN
cord-265941-eff4le0g	229	24	excessive	excessive	JJ
cord-265941-eff4le0g	229	25	IL-1β	il-1β	NN
cord-265941-eff4le0g	229	26	-	-	HYPH
cord-265941-eff4le0g	229	27	induced	induce	VBN
cord-265941-eff4le0g	229	28	inflammation	inflammation	NN
cord-265941-eff4le0g	229	29	[	[	-LRB-
cord-265941-eff4le0g	229	30	116	116	CD
cord-265941-eff4le0g	229	31	]	]	-RRB-
cord-265941-eff4le0g	229	32	.	.	.
cord-265941-eff4le0g	230	1	This	this	DT
cord-265941-eff4le0g	230	2	is	be	VBZ
cord-265941-eff4le0g	230	3	not	not	RB
cord-265941-eff4le0g	230	4	seen	see	VBN
cord-265941-eff4le0g	230	5	in	in	IN
cord-265941-eff4le0g	230	6	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	230	7	−	−	NNP
cord-265941-eff4le0g	230	8	/mice	/mice	NNP
cord-265941-eff4le0g	230	9	,	,	,
cord-265941-eff4le0g	230	10	likely	likely	RB
cord-265941-eff4le0g	230	11	due	due	IN
cord-265941-eff4le0g	230	12	to	to	IN
cord-265941-eff4le0g	230	13	RIPK3	ripk3	NN
cord-265941-eff4le0g	230	14	influence	influence	NN
cord-265941-eff4le0g	230	15	on	on	IN
cord-265941-eff4le0g	230	16	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	230	17	activation	activation	NN
cord-265941-eff4le0g	230	18	.	.	.
cord-265941-eff4le0g	231	1	These	these	DT
cord-265941-eff4le0g	231	2	results	result	NNS
cord-265941-eff4le0g	231	3	indicate	indicate	VBP
cord-265941-eff4le0g	231	4	tissue	tissue	NN
cord-265941-eff4le0g	231	5	-	-	HYPH
cord-265941-eff4le0g	231	6	specific	specific	JJ
cord-265941-eff4le0g	231	7	roles	role	NNS
cord-265941-eff4le0g	231	8	for	for	IN
cord-265941-eff4le0g	231	9	RIPKs	ripk	NNS
cord-265941-eff4le0g	231	10	during	during	IN
cord-265941-eff4le0g	231	11	S.	S.	NNP
cord-265941-eff4le0g	231	12	aureus	aureus	NN
cord-265941-eff4le0g	231	13	infection	infection	NN
cord-265941-eff4le0g	231	14	.	.	.
cord-265941-eff4le0g	232	1	Similarly	similarly	RB
cord-265941-eff4le0g	232	2	,	,	,
cord-265941-eff4le0g	232	3	Salmonella	Salmonella	NNP
cord-265941-eff4le0g	232	4	enterica	enterica	NN
cord-265941-eff4le0g	232	5	serovar	serovar	NNP
cord-265941-eff4le0g	232	6	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	232	7	(	(	-LRB-
cord-265941-eff4le0g	232	8	S.	S.	NNP
cord-265941-eff4le0g	232	9	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	232	10	)	)	-RRB-
cord-265941-eff4le0g	232	11	triggers	trigger	VBZ
cord-265941-eff4le0g	232	12	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	232	13	in	in	IN
cord-265941-eff4le0g	232	14	macrophages	macrophage	NNS
cord-265941-eff4le0g	232	15	to	to	TO
cord-265941-eff4le0g	232	16	benefit	benefit	VB
cord-265941-eff4le0g	232	17	bacterial	bacterial	JJ
cord-265941-eff4le0g	232	18	survival	survival	NN
cord-265941-eff4le0g	232	19	.	.	.
cord-265941-eff4le0g	233	1	This	this	DT
cord-265941-eff4le0g	233	2	process	process	NN
cord-265941-eff4le0g	233	3	is	be	VBZ
cord-265941-eff4le0g	233	4	dependent	dependent	JJ
cord-265941-eff4le0g	233	5	on	on	IN
cord-265941-eff4le0g	233	6	initial	initial	JJ
cord-265941-eff4le0g	233	7	type	type	NN
cord-265941-eff4le0g	234	1	I	-PRON-	PRP
cord-265941-eff4le0g	234	2	IFN	IFN	NNP
cord-265941-eff4le0g	234	3	signaling	signal	VBG
cord-265941-eff4le0g	234	4	following	follow	VBG
cord-265941-eff4le0g	234	5	injection	injection	NN
cord-265941-eff4le0g	234	6	of	of	IN
cord-265941-eff4le0g	234	7	S.	S.	NNP
cord-265941-eff4le0g	234	8	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	234	9	in	in	IN
cord-265941-eff4le0g	234	10	mice	mouse	NNS
cord-265941-eff4le0g	234	11	,	,	,
cord-265941-eff4le0g	234	12	as	as	RB
cord-265941-eff4le0g	234	13	well	well	RB
cord-265941-eff4le0g	234	14	as	as	IN
cord-265941-eff4le0g	234	15	pathogen	pathogen	NN
cord-265941-eff4le0g	234	16	-	-	HYPH
cord-265941-eff4le0g	234	17	mediated	mediate	VBN
cord-265941-eff4le0g	234	18	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	234	19	inactivation	inactivation	NN
cord-265941-eff4le0g	234	20	,	,	,
cord-265941-eff4le0g	234	21	which	which	WDT
cord-265941-eff4le0g	234	22	enables	enable	VBZ
cord-265941-eff4le0g	234	23	RIPK1	ripk1	JJ
cord-265941-eff4le0g	234	24	recruitment	recruitment	NN
cord-265941-eff4le0g	234	25	to	to	TO
cord-265941-eff4le0g	234	26	IFNAR1	ifnar1	VB
cord-265941-eff4le0g	234	27	for	for	IN
cord-265941-eff4le0g	234	28	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	234	29	and	and	CC
cord-265941-eff4le0g	234	30	subsequent	subsequent	JJ
cord-265941-eff4le0g	234	31	association	association	NN
cord-265941-eff4le0g	234	32	with	with	IN
cord-265941-eff4le0g	234	33	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	234	34	[	[	-LRB-
cord-265941-eff4le0g	234	35	117	117	CD
cord-265941-eff4le0g	234	36	]	]	-RRB-
cord-265941-eff4le0g	234	37	.	.	.
cord-265941-eff4le0g	235	1	The	the	DT
cord-265941-eff4le0g	235	2	resulting	result	VBG
cord-265941-eff4le0g	235	3	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	235	4	cell	cell	NN
cord-265941-eff4le0g	235	5	death	death	NN
cord-265941-eff4le0g	235	6	facilitates	facilitate	VBZ
cord-265941-eff4le0g	235	7	macrophage	macrophage	NN
cord-265941-eff4le0g	235	8	elimination	elimination	NN
cord-265941-eff4le0g	235	9	,	,	,
cord-265941-eff4le0g	235	10	leading	lead	VBG
cord-265941-eff4le0g	235	11	to	to	IN
cord-265941-eff4le0g	235	12	compromised	compromised	JJ
cord-265941-eff4le0g	235	13	pathogen	pathogen	NN
cord-265941-eff4le0g	235	14	control	control	NN
cord-265941-eff4le0g	235	15	.	.	.
cord-265941-eff4le0g	236	1	Alternatively	alternatively	RB
cord-265941-eff4le0g	236	2	,	,	,
cord-265941-eff4le0g	236	3	Ro	Ro	NNP
cord-265941-eff4le0g	236	4	et	et	FW
cord-265941-eff4le0g	236	5	al	al	NNP
cord-265941-eff4le0g	236	6	.	.	.
cord-265941-eff4le0g	237	1	[	[	-LRB-
cord-265941-eff4le0g	237	2	118	118	CD
cord-265941-eff4le0g	237	3	]	]	-RRB-
cord-265941-eff4le0g	237	4	reported	report	VBD
cord-265941-eff4le0g	237	5	that	that	IN
cord-265941-eff4le0g	237	6	microRNA	microRNA	NNP
cord-265941-eff4le0g	237	7	(	(	-LRB-
cord-265941-eff4le0g	237	8	miR)-155	miR)-155	NNP
cord-265941-eff4le0g	237	9	upregulation	upregulation	NN
cord-265941-eff4le0g	237	10	following	follow	VBG
cord-265941-eff4le0g	237	11	S.	S.	NNP
cord-265941-eff4le0g	237	12	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	237	13	infection	infection	NN
cord-265941-eff4le0g	237	14	drives	drive	VBZ
cord-265941-eff4le0g	237	15	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	237	16	macrophage	macrophage	NN
cord-265941-eff4le0g	237	17	death	death	NN
cord-265941-eff4le0g	237	18	.	.	.
cord-265941-eff4le0g	238	1	Transfection	transfection	NN
cord-265941-eff4le0g	238	2	of	of	IN
cord-265941-eff4le0g	238	3	miR-155	miR-155	NNP
cord-265941-eff4le0g	238	4	in	in	IN
cord-265941-eff4le0g	238	5	vitro	vitro	FW
cord-265941-eff4le0g	238	6	induces	induce	VBZ
cord-265941-eff4le0g	238	7	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	238	8	and	and	CC
cord-265941-eff4le0g	238	9	RIPK3	ripk3	NN
cord-265941-eff4le0g	238	10	activation	activation	NN
cord-265941-eff4le0g	238	11	and	and	CC
cord-265941-eff4le0g	238	12	subsequent	subsequent	JJ
cord-265941-eff4le0g	238	13	necroptosis	necroptosis	NN
cord-265941-eff4le0g	238	14	,	,	,
cord-265941-eff4le0g	238	15	which	which	WDT
cord-265941-eff4le0g	238	16	is	be	VBZ
cord-265941-eff4le0g	238	17	partly	partly	RB
cord-265941-eff4le0g	238	18	inhibited	inhibit	VBN
cord-265941-eff4le0g	238	19	following	follow	VBG
cord-265941-eff4le0g	238	20	Nec-1	Nec-1	NNP
cord-265941-eff4le0g	238	21	treatment	treatment	NN
cord-265941-eff4le0g	238	22	.	.	.
cord-265941-eff4le0g	239	1	It	-PRON-	PRP
cord-265941-eff4le0g	239	2	is	be	VBZ
cord-265941-eff4le0g	239	3	worth	worth	JJ
cord-265941-eff4le0g	239	4	noting	note	VBG
cord-265941-eff4le0g	239	5	that	that	IN
cord-265941-eff4le0g	239	6	although	although	IN
cord-265941-eff4le0g	239	7	the	the	DT
cord-265941-eff4le0g	239	8	authors	author	NNS
cord-265941-eff4le0g	239	9	describe	describe	VBP
cord-265941-eff4le0g	239	10	the	the	DT
cord-265941-eff4le0g	239	11	mode	mode	NN
cord-265941-eff4le0g	239	12	of	of	IN
cord-265941-eff4le0g	239	13	cell	cell	NN
cord-265941-eff4le0g	239	14	death	death	NN
cord-265941-eff4le0g	239	15	in	in	IN
cord-265941-eff4le0g	239	16	both	both	DT
cord-265941-eff4le0g	239	17	of	of	IN
cord-265941-eff4le0g	239	18	the	the	DT
cord-265941-eff4le0g	239	19	above	above	JJ
cord-265941-eff4le0g	239	20	S.	S.	NNP
cord-265941-eff4le0g	239	21	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	239	22	infection	infection	NN
cord-265941-eff4le0g	239	23	studies	study	NNS
cord-265941-eff4le0g	239	24	as	as	IN
cord-265941-eff4le0g	239	25	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	239	26	,	,	,
cord-265941-eff4le0g	239	27	no	no	DT
cord-265941-eff4le0g	239	28	experimental	experimental	JJ
cord-265941-eff4le0g	239	29	evidence	evidence	NN
cord-265941-eff4le0g	239	30	showing	show	VBG
cord-265941-eff4le0g	239	31	MLKL	MLKL	NNP
cord-265941-eff4le0g	239	32	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	239	33	or	or	CC
cord-265941-eff4le0g	239	34	dependence	dependence	NN
cord-265941-eff4le0g	239	35	on	on	IN
cord-265941-eff4le0g	239	36	MLKL	MLKL	NNP
cord-265941-eff4le0g	239	37	presence	presence	NN
cord-265941-eff4le0g	239	38	was	be	VBD
cord-265941-eff4le0g	239	39	provided	provide	VBN
cord-265941-eff4le0g	239	40	.	.	.
cord-265941-eff4le0g	240	1	Thus	thus	RB
cord-265941-eff4le0g	240	2	far	far	RB
cord-265941-eff4le0g	240	3	,	,	,
cord-265941-eff4le0g	240	4	studies	study	NNS
cord-265941-eff4le0g	240	5	on	on	IN
cord-265941-eff4le0g	240	6	mycobacterial	mycobacterial	NNP
cord-265941-eff4le0g	240	7	-	-	HYPH
cord-265941-eff4le0g	240	8	induced	induce	VBN
cord-265941-eff4le0g	240	9	necroptosis	necroptosis	NN
cord-265941-eff4le0g	240	10	in	in	IN
cord-265941-eff4le0g	240	11	macrophages	macrophage	NNS
cord-265941-eff4le0g	240	12	have	have	VBP
cord-265941-eff4le0g	240	13	been	be	VBN
cord-265941-eff4le0g	240	14	largely	largely	RB
cord-265941-eff4le0g	240	15	divisive	divisive	JJ
cord-265941-eff4le0g	240	16	.	.	.
cord-265941-eff4le0g	241	1	Mycobacterium	Mycobacterium	NNP
cord-265941-eff4le0g	241	2	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	241	3	triggers	trigger	VBZ
cord-265941-eff4le0g	241	4	RIPK3-dependent	RIPK3-dependent	:
cord-265941-eff4le0g	241	5	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	241	6	in	in	IN
cord-265941-eff4le0g	241	7	both	both	CC
cord-265941-eff4le0g	241	8	human	human	JJ
cord-265941-eff4le0g	241	9	and	and	CC
cord-265941-eff4le0g	241	10	murine	murine	JJ
cord-265941-eff4le0g	241	11	macrophages	macrophage	NNS
cord-265941-eff4le0g	241	12	in	in	IN
cord-265941-eff4le0g	241	13	a	a	DT
cord-265941-eff4le0g	241	14	pathway	pathway	NN
cord-265941-eff4le0g	241	15	reliant	reliant	JJ
cord-265941-eff4le0g	241	16	on	on	IN
cord-265941-eff4le0g	241	17	reactive	reactive	JJ
cord-265941-eff4le0g	241	18	oxygen	oxygen	NN
cord-265941-eff4le0g	241	19	species	specie	NNS
cord-265941-eff4le0g	241	20	(	(	-LRB-
cord-265941-eff4le0g	241	21	ROS	ROS	NNP
cord-265941-eff4le0g	241	22	)	)	-RRB-
cord-265941-eff4le0g	241	23	production	production	NN
cord-265941-eff4le0g	241	24	and	and	CC
cord-265941-eff4le0g	241	25	the	the	DT
cord-265941-eff4le0g	241	26	mitochondrial	mitochondrial	NN
cord-265941-eff4le0g	241	27	Bcl-2	Bcl-2	NNP
cord-265941-eff4le0g	241	28	family	family	NN
cord-265941-eff4le0g	241	29	member	member	NN
cord-265941-eff4le0g	241	30	protein	protein	NN
cord-265941-eff4le0g	241	31	B	b	NN
cord-265941-eff4le0g	241	32	-	-	HYPH
cord-265941-eff4le0g	241	33	cell	cell	NN
cord-265941-eff4le0g	241	34	lymphoma	lymphoma	NN
cord-265941-eff4le0g	242	1	-extra	-extra	:
cord-265941-eff4le0g	242	2	large	large	JJ
cord-265941-eff4le0g	242	3	(	(	-LRB-
cord-265941-eff4le0g	242	4	Bcl	Bcl	NNP
cord-265941-eff4le0g	242	5	-	-	HYPH
cord-265941-eff4le0g	242	6	xL	xL	NNP
cord-265941-eff4le0g	242	7	)	)	-RRB-
cord-265941-eff4le0g	243	1	[	[	-LRB-
cord-265941-eff4le0g	243	2	119	119	CD
cord-265941-eff4le0g	243	3	,	,	,
cord-265941-eff4le0g	243	4	120	120	CD
cord-265941-eff4le0g	243	5	]	]	-RRB-
cord-265941-eff4le0g	243	6	.	.	.
cord-265941-eff4le0g	244	1	The	the	DT
cord-265941-eff4le0g	244	2	ensuing	ensue	VBG
cord-265941-eff4le0g	244	3	macrophage	macrophage	NN
cord-265941-eff4le0g	244	4	death	death	NN
cord-265941-eff4le0g	244	5	is	be	VBZ
cord-265941-eff4le0g	244	6	suggested	suggest	VBN
cord-265941-eff4le0g	244	7	to	to	TO
cord-265941-eff4le0g	244	8	assist	assist	VB
cord-265941-eff4le0g	244	9	bacterial	bacterial	JJ
cord-265941-eff4le0g	244	10	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	244	11	,	,	,
cord-265941-eff4le0g	244	12	as	as	IN
cord-265941-eff4le0g	244	13	Ripk3	Ripk3	NNS
cord-265941-eff4le0g	244	14	−	−	NNP
cord-265941-eff4le0g	245	1	/−	/−	.
cord-265941-eff4le0g	246	1	macrophages	macrophage	NNS
cord-265941-eff4le0g	246	2	display	display	VBP
cord-265941-eff4le0g	246	3	enhanced	enhance	VBN
cord-265941-eff4le0g	246	4	restriction	restriction	NN
cord-265941-eff4le0g	246	5	of	of	IN
cord-265941-eff4le0g	246	6	bacterial	bacterial	JJ
cord-265941-eff4le0g	246	7	replication	replication	NN
cord-265941-eff4le0g	246	8	in	in	IN
cord-265941-eff4le0g	246	9	vitro	vitro	FW
cord-265941-eff4le0g	246	10	and	and	CC
cord-265941-eff4le0g	246	11	in	in	IN
cord-265941-eff4le0g	246	12	vivo	vivo	NNP
cord-265941-eff4le0g	246	13	.	.	.
cord-265941-eff4le0g	247	1	However	however	RB
cord-265941-eff4le0g	247	2	,	,	,
cord-265941-eff4le0g	247	3	despite	despite	IN
cord-265941-eff4le0g	247	4	increased	increase	VBN
cord-265941-eff4le0g	247	5	MLKL	MLKL	NNP
cord-265941-eff4le0g	247	6	expression	expression	NN
cord-265941-eff4le0g	247	7	,	,	,
cord-265941-eff4le0g	247	8	pMLKL	pMLKL	NNP
cord-265941-eff4le0g	247	9	is	be	VBZ
cord-265941-eff4le0g	247	10	not	not	RB
cord-265941-eff4le0g	247	11	detected	detect	VBN
cord-265941-eff4le0g	247	12	in	in	IN
cord-265941-eff4le0g	247	13	infected	infected	JJ
cord-265941-eff4le0g	247	14	macrophages	macrophage	NNS
cord-265941-eff4le0g	247	15	,	,	,
cord-265941-eff4le0g	247	16	suggesting	suggest	VBG
cord-265941-eff4le0g	247	17	that	that	IN
cord-265941-eff4le0g	247	18	the	the	DT
cord-265941-eff4le0g	247	19	signaling	signaling	NN
cord-265941-eff4le0g	247	20	process	process	NN
cord-265941-eff4le0g	247	21	utilises	utilise	VBZ
cord-265941-eff4le0g	247	22	an	an	DT
cord-265941-eff4le0g	247	23	alternative	alternative	JJ
cord-265941-eff4le0g	247	24	executioner	executioner	NN
cord-265941-eff4le0g	247	25	or	or	CC
cord-265941-eff4le0g	247	26	is	be	VBZ
cord-265941-eff4le0g	247	27	non	non	JJ
cord-265941-eff4le0g	247	28	-	-	JJ
cord-265941-eff4le0g	247	29	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	247	30	.	.	.
cord-265941-eff4le0g	248	1	This	this	DT
cord-265941-eff4le0g	248	2	is	be	VBZ
cord-265941-eff4le0g	248	3	further	far	RBR
cord-265941-eff4le0g	248	4	complicated	complicate	VBN
cord-265941-eff4le0g	248	5	by	by	IN
cord-265941-eff4le0g	248	6	results	result	NNS
cord-265941-eff4le0g	248	7	from	from	IN
cord-265941-eff4le0g	248	8	Stutz	Stutz	NNP
cord-265941-eff4le0g	248	9	et	et	NNP
cord-265941-eff4le0g	248	10	al	al	NNP
cord-265941-eff4le0g	248	11	.	.	.
cord-265941-eff4le0g	249	1	[	[	-LRB-
cord-265941-eff4le0g	249	2	121	121	CD
cord-265941-eff4le0g	249	3	,	,	,
cord-265941-eff4le0g	249	4	122	122	CD
cord-265941-eff4le0g	249	5	]	]	-RRB-
cord-265941-eff4le0g	249	6	,	,	,
cord-265941-eff4le0g	249	7	which	which	WDT
cord-265941-eff4le0g	249	8	argue	argue	VBP
cord-265941-eff4le0g	249	9	that	that	IN
cord-265941-eff4le0g	249	10	deletion	deletion	NN
cord-265941-eff4le0g	249	11	of	of	IN
cord-265941-eff4le0g	249	12	MLKL	MLKL	NNP
cord-265941-eff4le0g	249	13	or	or	CC
cord-265941-eff4le0g	249	14	RIPK3	ripk3	NN
cord-265941-eff4le0g	249	15	does	do	VBZ
cord-265941-eff4le0g	249	16	not	not	RB
cord-265941-eff4le0g	249	17	rescue	rescue	VB
cord-265941-eff4le0g	249	18	macrophages	macrophage	NNS
cord-265941-eff4le0g	249	19	from	from	IN
cord-265941-eff4le0g	249	20	death	death	NN
cord-265941-eff4le0g	249	21	during	during	IN
cord-265941-eff4le0g	249	22	M.	M.	NNP
cord-265941-eff4le0g	249	23	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	249	24	infection	infection	NN
cord-265941-eff4le0g	249	25	.	.	.
cord-265941-eff4le0g	250	1	In	in	IN
cord-265941-eff4le0g	250	2	fact	fact	NN
cord-265941-eff4le0g	250	3	,	,	,
cord-265941-eff4le0g	250	4	the	the	DT
cord-265941-eff4le0g	250	5	macrophage	macrophage	NN
cord-265941-eff4le0g	250	6	population	population	NN
cord-265941-eff4le0g	250	7	and	and	CC
cord-265941-eff4le0g	250	8	bacterial	bacterial	JJ
cord-265941-eff4le0g	250	9	burden	burden	NN
cord-265941-eff4le0g	250	10	in	in	IN
cord-265941-eff4le0g	250	11	infected	infect	VBN
cord-265941-eff4le0g	251	1	Ripk3	Ripk3	NNPS
cord-265941-eff4le0g	252	1	-/mice	-/mice	NNP
cord-265941-eff4le0g	252	2	are	be	VBP
cord-265941-eff4le0g	252	3	indistinguishable	indistinguishable	JJ
cord-265941-eff4le0g	252	4	from	from	IN
cord-265941-eff4le0g	252	5	WT	WT	NNP
cord-265941-eff4le0g	252	6	controls	control	NNS
cord-265941-eff4le0g	252	7	.	.	.
cord-265941-eff4le0g	253	1	Further	further	JJ
cord-265941-eff4le0g	253	2	research	research	NN
cord-265941-eff4le0g	253	3	is	be	VBZ
cord-265941-eff4le0g	253	4	required	require	VBN
cord-265941-eff4le0g	253	5	to	to	TO
cord-265941-eff4le0g	253	6	ascribe	ascribe	VB
cord-265941-eff4le0g	253	7	a	a	DT
cord-265941-eff4le0g	253	8	role	role	NN
cord-265941-eff4le0g	253	9	for	for	IN
cord-265941-eff4le0g	253	10	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	253	11	in	in	IN
cord-265941-eff4le0g	253	12	mycobacterial	mycobacterial	NNP
cord-265941-eff4le0g	253	13	infections	infection	NNS
cord-265941-eff4le0g	253	14	.	.	.
cord-265941-eff4le0g	254	1	Host	host	NN
cord-265941-eff4le0g	254	2	cell	cell	NN
cord-265941-eff4le0g	254	3	death	death	NN
cord-265941-eff4le0g	254	4	and	and	CC
cord-265941-eff4le0g	254	5	inflammation	inflammation	NN
cord-265941-eff4le0g	254	6	can	can	MD
cord-265941-eff4le0g	254	7	also	also	RB
cord-265941-eff4le0g	254	8	be	be	VB
cord-265941-eff4le0g	254	9	induced	induce	VBN
cord-265941-eff4le0g	254	10	independently	independently	RB
cord-265941-eff4le0g	254	11	of	of	IN
cord-265941-eff4le0g	254	12	death	death	NN
cord-265941-eff4le0g	254	13	receptors	receptor	NNS
cord-265941-eff4le0g	254	14	through	through	IN
cord-265941-eff4le0g	254	15	inflammasome	inflammasome	NN
cord-265941-eff4le0g	254	16	signaling	signaling	NN
cord-265941-eff4le0g	254	17	,	,	,
cord-265941-eff4le0g	254	18	as	as	IN
cord-265941-eff4le0g	254	19	depicted	depict	VBN
cord-265941-eff4le0g	254	20	in	in	IN
cord-265941-eff4le0g	254	21	Fig	Fig	NNP
cord-265941-eff4le0g	254	22	.	.	.
cord-265941-eff4le0g	255	1	2	2	LS
cord-265941-eff4le0g	255	2	.	.	.
cord-265941-eff4le0g	256	1	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	257	1	and	and	CC
cord-265941-eff4le0g	257	2	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	257	3	are	be	VBP
cord-265941-eff4le0g	257	4	primarily	primarily	RB
cord-265941-eff4le0g	257	5	involved	involve	VBN
cord-265941-eff4le0g	257	6	in	in	IN
cord-265941-eff4le0g	257	7	alternative	alternative	JJ
cord-265941-eff4le0g	257	8	inflammasome	inflammasome	NN
cord-265941-eff4le0g	257	9	activation	activation	NN
cord-265941-eff4le0g	257	10	pathways	pathway	NNS
cord-265941-eff4le0g	257	11	,	,	,
cord-265941-eff4le0g	257	12	which	which	WDT
cord-265941-eff4le0g	257	13	remain	remain	VBP
cord-265941-eff4le0g	257	14	largely	largely	RB
cord-265941-eff4le0g	257	15	unexplored	unexplored	JJ
cord-265941-eff4le0g	257	16	.	.	.
cord-265941-eff4le0g	258	1	A	a	DT
cord-265941-eff4le0g	258	2	number	number	NN
cord-265941-eff4le0g	258	3	of	of	IN
cord-265941-eff4le0g	258	4	studies	study	NNS
cord-265941-eff4le0g	258	5	have	have	VBP
cord-265941-eff4le0g	258	6	used	use	VBN
cord-265941-eff4le0g	258	7	purified	purify	VBN
cord-265941-eff4le0g	258	8	pathogen	pathogen	NN
cord-265941-eff4le0g	258	9	components	component	NNS
cord-265941-eff4le0g	258	10	such	such	JJ
cord-265941-eff4le0g	258	11	as	as	IN
cord-265941-eff4le0g	258	12	LPS	LPS	NNP
cord-265941-eff4le0g	258	13	to	to	TO
cord-265941-eff4le0g	258	14	investigate	investigate	VB
cord-265941-eff4le0g	258	15	the	the	DT
cord-265941-eff4le0g	258	16	outcomes	outcome	NNS
cord-265941-eff4le0g	258	17	of	of	IN
cord-265941-eff4le0g	258	18	RIPK1/3-mediated	ripk1/3-mediate	VBN
cord-265941-eff4le0g	258	19	inflammasome	inflammasome	NN
cord-265941-eff4le0g	258	20	signaling	signaling	NN
cord-265941-eff4le0g	258	21	,	,	,
cord-265941-eff4le0g	258	22	which	which	WDT
cord-265941-eff4le0g	258	23	appear	appear	VBP
cord-265941-eff4le0g	258	24	to	to	TO
cord-265941-eff4le0g	258	25	be	be	VB
cord-265941-eff4le0g	258	26	largely	largely	RB
cord-265941-eff4le0g	258	27	dependent	dependent	JJ
cord-265941-eff4le0g	258	28	on	on	IN
cord-265941-eff4le0g	258	29	cell	cell	NN
cord-265941-eff4le0g	258	30	type	type	NN
cord-265941-eff4le0g	258	31	,	,	,
cord-265941-eff4le0g	258	32	stimulus	stimulus	NN
cord-265941-eff4le0g	258	33	,	,	,
cord-265941-eff4le0g	258	34	and	and	CC
cord-265941-eff4le0g	258	35	the	the	DT
cord-265941-eff4le0g	258	36	availability	availability	NN
cord-265941-eff4le0g	258	37	or	or	CC
cord-265941-eff4le0g	258	38	functional	functional	JJ
cord-265941-eff4le0g	258	39	activity	activity	NN
cord-265941-eff4le0g	258	40	of	of	IN
cord-265941-eff4le0g	258	41	certain	certain	JJ
cord-265941-eff4le0g	258	42	host	host	NN
cord-265941-eff4le0g	258	43	signaling	signal	VBG
cord-265941-eff4le0g	258	44	proteins	protein	NNS
cord-265941-eff4le0g	258	45	[	[	-LRB-
cord-265941-eff4le0g	258	46	65	65	CD
cord-265941-eff4le0g	258	47	,	,	,
cord-265941-eff4le0g	258	48	[	[	-LRB-
cord-265941-eff4le0g	258	49	123	123	CD
cord-265941-eff4le0g	258	50	]	]	-RRB-
cord-265941-eff4le0g	258	51	[	[	-LRB-
cord-265941-eff4le0g	258	52	124	124	CD
cord-265941-eff4le0g	258	53	]	]	-RRB-
cord-265941-eff4le0g	258	54	[	[	-LRB-
cord-265941-eff4le0g	258	55	125	125	CD
cord-265941-eff4le0g	258	56	]	]	-RRB-
cord-265941-eff4le0g	258	57	[	[	-LRB-
cord-265941-eff4le0g	258	58	126	126	CD
cord-265941-eff4le0g	258	59	]	]	-RRB-
cord-265941-eff4le0g	258	60	[	[	-LRB-
cord-265941-eff4le0g	258	61	127	127	CD
cord-265941-eff4le0g	258	62	]	]	-RRB-
cord-265941-eff4le0g	258	63	.	.	.
cord-265941-eff4le0g	259	1	Here	here	RB
cord-265941-eff4le0g	259	2	we	-PRON-	PRP
cord-265941-eff4le0g	259	3	will	will	MD
cord-265941-eff4le0g	259	4	discuss	discuss	VB
cord-265941-eff4le0g	259	5	RIPK1	ripk1	JJ
cord-265941-eff4le0g	259	6	and	and	CC
cord-265941-eff4le0g	259	7	RIPK3	ripk3	NN
cord-265941-eff4le0g	259	8	involvement	involvement	NN
cord-265941-eff4le0g	259	9	in	in	IN
cord-265941-eff4le0g	259	10	inflammasome	inflammasome	NN
cord-265941-eff4le0g	259	11	signaling	signal	VBG
cord-265941-eff4le0g	259	12	during	during	IN
cord-265941-eff4le0g	259	13	pathogen	pathogen	NN
cord-265941-eff4le0g	259	14	-	-	HYPH
cord-265941-eff4le0g	259	15	specific	specific	JJ
cord-265941-eff4le0g	259	16	infections	infection	NNS
cord-265941-eff4le0g	259	17	.	.	.
cord-265941-eff4le0g	260	1	Vesicular	vesicular	JJ
cord-265941-eff4le0g	260	2	stomatitis	stomatitis	NN
cord-265941-eff4le0g	260	3	virus	virus	NN
cord-265941-eff4le0g	260	4	(	(	-LRB-
cord-265941-eff4le0g	260	5	VSV	VSV	NNP
cord-265941-eff4le0g	260	6	)	)	-RRB-
cord-265941-eff4le0g	260	7	is	be	VBZ
cord-265941-eff4le0g	260	8	a	a	DT
cord-265941-eff4le0g	260	9	rhabdovirus	rhabdovirus	NN
cord-265941-eff4le0g	260	10	that	that	WDT
cord-265941-eff4le0g	260	11	causes	cause	VBZ
cord-265941-eff4le0g	260	12	vesicular	vesicular	JJ
cord-265941-eff4le0g	260	13	lesions	lesion	NNS
cord-265941-eff4le0g	260	14	on	on	IN
cord-265941-eff4le0g	260	15	the	the	DT
cord-265941-eff4le0g	260	16	mucosa	mucosa	NN
cord-265941-eff4le0g	260	17	of	of	IN
cord-265941-eff4le0g	260	18	livestock	livestock	NN
cord-265941-eff4le0g	260	19	[	[	-LRB-
cord-265941-eff4le0g	260	20	128	128	CD
cord-265941-eff4le0g	260	21	]	]	-RRB-
cord-265941-eff4le0g	260	22	.	.	.
cord-265941-eff4le0g	261	1	VSV	VSV	NNP
cord-265941-eff4le0g	261	2	-	-	HYPH
cord-265941-eff4le0g	261	3	infected	infect	VBN
cord-265941-eff4le0g	261	4	mice	mouse	NNS
cord-265941-eff4le0g	261	5	exhibit	exhibit	NN
cord-265941-eff4le0g	261	6	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	261	7	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	261	8	activation	activation	NN
cord-265941-eff4le0g	261	9	,	,	,
cord-265941-eff4le0g	261	10	characterised	characterise	VBN
cord-265941-eff4le0g	261	11	by	by	IN
cord-265941-eff4le0g	261	12	elevated	elevated	JJ
cord-265941-eff4le0g	261	13	levels	level	NNS
cord-265941-eff4le0g	261	14	of	of	IN
cord-265941-eff4le0g	261	15	cleaved	cleave	VBN
cord-265941-eff4le0g	261	16	caspase-1	caspase-1	NNP
cord-265941-eff4le0g	261	17	,	,	,
cord-265941-eff4le0g	261	18	as	as	RB
cord-265941-eff4le0g	261	19	well	well	RB
cord-265941-eff4le0g	261	20	as	as	IN
cord-265941-eff4le0g	261	21	IL-1β	IL-1β	NNP
cord-265941-eff4le0g	261	22	and	and	CC
cord-265941-eff4le0g	261	23	IL-18	IL-18	NNP
cord-265941-eff4le0g	261	24	secretion	secretion	NN
cord-265941-eff4le0g	261	25	[	[	-LRB-
cord-265941-eff4le0g	261	26	129	129	CD
cord-265941-eff4le0g	261	27	]	]	-RRB-
cord-265941-eff4le0g	261	28	.	.	.
cord-265941-eff4le0g	262	1	Here	here	RB
cord-265941-eff4le0g	262	2	,	,	,
cord-265941-eff4le0g	262	3	RIPK1	ripk1	JJ
cord-265941-eff4le0g	262	4	complexes	complex	NNS
cord-265941-eff4le0g	262	5	with	with	IN
cord-265941-eff4le0g	262	6	RIPK3	ripk3	NN
cord-265941-eff4le0g	262	7	following	follow	VBG
cord-265941-eff4le0g	262	8	stimulation	stimulation	NN
cord-265941-eff4le0g	262	9	of	of	IN
cord-265941-eff4le0g	262	10	a	a	DT
cord-265941-eff4le0g	262	11	yet	yet	RB
cord-265941-eff4le0g	262	12	unidentified	unidentified	JJ
cord-265941-eff4le0g	262	13	RNA	RNA	NNP
cord-265941-eff4le0g	262	14	sensor	sensor	NN
cord-265941-eff4le0g	262	15	,	,	,
cord-265941-eff4le0g	262	16	which	which	WDT
cord-265941-eff4le0g	262	17	enables	enable	VBZ
cord-265941-eff4le0g	262	18	RIPK1-mediated	RIPK1-mediated	NNP
cord-265941-eff4le0g	262	19	activation	activation	NN
cord-265941-eff4le0g	262	20	of	of	IN
cord-265941-eff4le0g	262	21	dynamin	dynamin	NN
cord-265941-eff4le0g	262	22	-	-	HYPH
cord-265941-eff4le0g	262	23	related	relate	VBN
cord-265941-eff4le0g	262	24	protein	protein	NN
cord-265941-eff4le0g	262	25	1	1	CD
cord-265941-eff4le0g	262	26	(	(	-LRB-
cord-265941-eff4le0g	262	27	DRP1	DRP1	NNP
cord-265941-eff4le0g	262	28	)	)	-RRB-
cord-265941-eff4le0g	262	29	.	.	.
cord-265941-eff4le0g	263	1	Subsequent	subsequent	JJ
cord-265941-eff4le0g	263	2	translocation	translocation	NN
cord-265941-eff4le0g	263	3	of	of	IN
cord-265941-eff4le0g	263	4	DRP1	DRP1	NNP
cord-265941-eff4le0g	263	5	to	to	IN
cord-265941-eff4le0g	263	6	the	the	DT
cord-265941-eff4le0g	263	7	mitochondria	mitochondria	NN
cord-265941-eff4le0g	263	8	promotes	promote	VBZ
cord-265941-eff4le0g	263	9	aberrant	aberrant	JJ
cord-265941-eff4le0g	263	10	fission	fission	NN
cord-265941-eff4le0g	263	11	and	and	CC
cord-265941-eff4le0g	263	12	ROS	ROS	NNP
cord-265941-eff4le0g	263	13	production	production	NN
cord-265941-eff4le0g	263	14	in	in	IN
cord-265941-eff4le0g	263	15	both	both	DT
cord-265941-eff4le0g	263	16	mouse	mouse	NN
cord-265941-eff4le0g	263	17	and	and	CC
cord-265941-eff4le0g	263	18	human	human	NN
cord-265941-eff4le0g	263	19	cells	cell	NNS
cord-265941-eff4le0g	263	20	,	,	,
cord-265941-eff4le0g	263	21	thus	thus	RB
cord-265941-eff4le0g	263	22	activating	activate	VBG
cord-265941-eff4le0g	263	23	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	263	24	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	263	25	.	.	.
cord-265941-eff4le0g	264	1	This	this	DT
cord-265941-eff4le0g	264	2	DRP1-mediated	DRP1-mediated	NNP
cord-265941-eff4le0g	264	3	inflammasome	inflammasome	NN
cord-265941-eff4le0g	264	4	signaling	signaling	NN
cord-265941-eff4le0g	264	5	is	be	VBZ
cord-265941-eff4le0g	264	6	reported	report	VBN
cord-265941-eff4le0g	264	7	to	to	TO
cord-265941-eff4le0g	264	8	also	also	RB
cord-265941-eff4le0g	264	9	occur	occur	VB
cord-265941-eff4le0g	264	10	in	in	IN
cord-265941-eff4le0g	264	11	response	response	NN
cord-265941-eff4le0g	264	12	to	to	IN
cord-265941-eff4le0g	264	13	dengue	dengue	NN
cord-265941-eff4le0g	264	14	virus	virus	NN
cord-265941-eff4le0g	264	15	[	[	-LRB-
cord-265941-eff4le0g	264	16	130	130	CD
cord-265941-eff4le0g	264	17	]	]	-RRB-
cord-265941-eff4le0g	264	18	and	and	CC
cord-265941-eff4le0g	264	19	swine	swine	NN
cord-265941-eff4le0g	264	20	influenza	influenza	NN
cord-265941-eff4le0g	264	21	virus	virus	NN
cord-265941-eff4le0g	264	22	infection	infection	NN
cord-265941-eff4le0g	264	23	[	[	-LRB-
cord-265941-eff4le0g	264	24	131	131	CD
cord-265941-eff4le0g	264	25	]	]	-RRB-
cord-265941-eff4le0g	264	26	.	.	.
cord-265941-eff4le0g	265	1	Some	some	DT
cord-265941-eff4le0g	265	2	studies	study	NNS
cord-265941-eff4le0g	265	3	contradict	contradict	VBP
cord-265941-eff4le0g	265	4	these	these	DT
cord-265941-eff4le0g	265	5	observations	observation	NNS
cord-265941-eff4le0g	265	6	[	[	-LRB-
cord-265941-eff4le0g	265	7	132	132	CD
cord-265941-eff4le0g	265	8	]	]	-RRB-
cord-265941-eff4le0g	265	9	[	[	-LRB-
cord-265941-eff4le0g	265	10	133	133	CD
cord-265941-eff4le0g	265	11	]	]	-RRB-
cord-265941-eff4le0g	265	12	[	[	-LRB-
cord-265941-eff4le0g	265	13	134	134	CD
cord-265941-eff4le0g	265	14	]	]	-RRB-
cord-265941-eff4le0g	265	15	,	,	,
cord-265941-eff4le0g	265	16	likely	likely	RB
cord-265941-eff4le0g	265	17	due	due	IN
cord-265941-eff4le0g	265	18	to	to	IN
cord-265941-eff4le0g	265	19	different	different	JJ
cord-265941-eff4le0g	265	20	experimental	experimental	JJ
cord-265941-eff4le0g	265	21	models	model	NNS
cord-265941-eff4le0g	265	22	,	,	,
cord-265941-eff4le0g	265	23	therefore	therefore	RB
cord-265941-eff4le0g	265	24	additional	additional	JJ
cord-265941-eff4le0g	265	25	research	research	NN
cord-265941-eff4le0g	265	26	is	be	VBZ
cord-265941-eff4le0g	265	27	necessary	necessary	JJ
cord-265941-eff4le0g	265	28	to	to	TO
cord-265941-eff4le0g	265	29	conclusively	conclusively	RB
cord-265941-eff4le0g	265	30	define	define	VB
cord-265941-eff4le0g	265	31	this	this	DT
cord-265941-eff4le0g	265	32	form	form	NN
cord-265941-eff4le0g	265	33	of	of	IN
cord-265941-eff4le0g	265	34	NLRP3	nlrp3	NN
cord-265941-eff4le0g	265	35	signaling	signaling	NN
cord-265941-eff4le0g	265	36	.	.	.
cord-265941-eff4le0g	266	1	Yersinia	Yersinia	NNP
cord-265941-eff4le0g	266	2	is	be	VBZ
cord-265941-eff4le0g	266	3	capable	capable	JJ
cord-265941-eff4le0g	266	4	of	of	IN
cord-265941-eff4le0g	266	5	inducing	induce	VBG
cord-265941-eff4le0g	266	6	caspase-1	caspase-1	NNP
cord-265941-eff4le0g	266	7	processing	processing	NN
cord-265941-eff4le0g	266	8	and	and	CC
cord-265941-eff4le0g	266	9	cell	cell	NN
cord-265941-eff4le0g	266	10	death	death	NN
cord-265941-eff4le0g	266	11	following	follow	VBG
cord-265941-eff4le0g	266	12	infection	infection	NN
cord-265941-eff4le0g	266	13	of	of	IN
cord-265941-eff4le0g	266	14	mouse	mouse	NN
cord-265941-eff4le0g	266	15	macrophages	macrophage	NNS
cord-265941-eff4le0g	266	16	[	[	-LRB-
cord-265941-eff4le0g	266	17	39	39	CD
cord-265941-eff4le0g	266	18	,	,	,
cord-265941-eff4le0g	266	19	135	135	CD
cord-265941-eff4le0g	266	20	,	,	,
cord-265941-eff4le0g	266	21	136	136	CD
cord-265941-eff4le0g	266	22	]	]	-RRB-
cord-265941-eff4le0g	266	23	.	.	.
cord-265941-eff4le0g	267	1	This	this	DT
cord-265941-eff4le0g	267	2	is	be	VBZ
cord-265941-eff4le0g	267	3	driven	drive	VBN
cord-265941-eff4le0g	267	4	by	by	IN
cord-265941-eff4le0g	267	5	YopJ	YopJ	NNP
cord-265941-eff4le0g	267	6	-	-	HYPH
cord-265941-eff4le0g	267	7	mediated	mediate	VBN
cord-265941-eff4le0g	267	8	suppression	suppression	NN
cord-265941-eff4le0g	267	9	of	of	IN
cord-265941-eff4le0g	267	10	TAK1	TAK1	NNP
cord-265941-eff4le0g	267	11	,	,	,
cord-265941-eff4le0g	267	12	which	which	WDT
cord-265941-eff4le0g	267	13	enables	enable	VBZ
cord-265941-eff4le0g	267	14	RIPK1	ripk1	JJ
cord-265941-eff4le0g	267	15	,	,	,
cord-265941-eff4le0g	267	16	FADD	FADD	NNP
cord-265941-eff4le0g	267	17	and	and	CC
cord-265941-eff4le0g	267	18	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	267	19	recruitment	recruitment	NN
cord-265941-eff4le0g	267	20	,	,	,
cord-265941-eff4le0g	267	21	and	and	CC
cord-265941-eff4le0g	267	22	subsequent	subsequent	JJ
cord-265941-eff4le0g	267	23	activation	activation	NN
cord-265941-eff4le0g	267	24	of	of	IN
cord-265941-eff4le0g	267	25	caspase1	caspase1	NN
cord-265941-eff4le0g	267	26	.	.	.
cord-265941-eff4le0g	268	1	The	the	DT
cord-265941-eff4le0g	268	2	resulting	result	VBG
cord-265941-eff4le0g	268	3	cell	cell	NN
cord-265941-eff4le0g	268	4	death	death	NN
cord-265941-eff4le0g	268	5	exhibits	exhibit	VBZ
cord-265941-eff4le0g	268	6	significant	significant	JJ
cord-265941-eff4le0g	268	7	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	268	8	/	/	SYM
cord-265941-eff4le0g	268	9	caspase-8-mediated	caspase-8-mediate	VBN
cord-265941-eff4le0g	268	10	GSDMD	GSDMD	NNP
cord-265941-eff4le0g	268	11	cleavage	cleavage	NN
cord-265941-eff4le0g	268	12	,	,	,
cord-265941-eff4le0g	268	13	implicating	implicate	VBG
cord-265941-eff4le0g	268	14	pyroptosis	pyroptosis	NN
cord-265941-eff4le0g	268	15	in	in	IN
cord-265941-eff4le0g	268	16	this	this	DT
cord-265941-eff4le0g	268	17	process	process	NN
cord-265941-eff4le0g	268	18	[	[	-LRB-
cord-265941-eff4le0g	268	19	136	136	CD
cord-265941-eff4le0g	268	20	]	]	-RRB-
cord-265941-eff4le0g	268	21	.	.	.
cord-265941-eff4le0g	269	1	Notably	notably	RB
cord-265941-eff4le0g	269	2	,	,	,
cord-265941-eff4le0g	269	3	NLRP3	nlrp3	NN
cord-265941-eff4le0g	269	4	and	and	CC
cord-265941-eff4le0g	269	5	caspase-1/11	caspase-1/11	NNS
cord-265941-eff4le0g	269	6	are	be	VBP
cord-265941-eff4le0g	269	7	not	not	RB
cord-265941-eff4le0g	269	8	involved	involve	VBN
cord-265941-eff4le0g	269	9	in	in	IN
cord-265941-eff4le0g	269	10	this	this	DT
cord-265941-eff4le0g	269	11	pyroptotic	pyroptotic	JJ
cord-265941-eff4le0g	269	12	pathway	pathway	NN
cord-265941-eff4le0g	269	13	,	,	,
cord-265941-eff4le0g	269	14	but	but	CC
cord-265941-eff4le0g	269	15	instead	instead	RB
cord-265941-eff4le0g	269	16	activated	activate	VBD
cord-265941-eff4le0g	269	17	following	follow	VBG
cord-265941-eff4le0g	269	18	potassium	potassium	NN
cord-265941-eff4le0g	269	19	efflux	efflux	NN
cord-265941-eff4le0g	269	20	to	to	TO
cord-265941-eff4le0g	269	21	promote	promote	VB
cord-265941-eff4le0g	269	22	IL-1β	il-1β	NN
cord-265941-eff4le0g	269	23	processing	processing	NN
cord-265941-eff4le0g	269	24	and	and	CC
cord-265941-eff4le0g	269	25	release	release	NN
cord-265941-eff4le0g	269	26	.	.	.
cord-265941-eff4le0g	270	1	These	these	DT
cord-265941-eff4le0g	270	2	observations	observation	NNS
cord-265941-eff4le0g	270	3	illustrate	illustrate	VBP
cord-265941-eff4le0g	270	4	an	an	DT
cord-265941-eff4le0g	270	5	alternative	alternative	JJ
cord-265941-eff4le0g	270	6	NLRP3-independent	NLRP3-independent	NNP
cord-265941-eff4le0g	270	7	mechanism	mechanism	NN
cord-265941-eff4le0g	270	8	for	for	IN
cord-265941-eff4le0g	270	9	caspase-1	caspase-1	NNP
cord-265941-eff4le0g	270	10	and	and	CC
cord-265941-eff4le0g	270	11	GSDMD	GSDMD	NNP
cord-265941-eff4le0g	270	12	activation	activation	NN
cord-265941-eff4le0g	270	13	during	during	IN
cord-265941-eff4le0g	270	14	Yersinia	Yersinia	NNP
cord-265941-eff4le0g	270	15	infection	infection	NN
cord-265941-eff4le0g	270	16	.	.	.
cord-265941-eff4le0g	271	1	RIPK2	ripk2	XX
cord-265941-eff4le0g	272	1	(	(	-LRB-
cord-265941-eff4le0g	272	2	also	also	RB
cord-265941-eff4le0g	272	3	known	know	VBN
cord-265941-eff4le0g	272	4	as	as	IN
cord-265941-eff4le0g	272	5	RIP2	RIP2	NNP
cord-265941-eff4le0g	272	6	,	,	,
cord-265941-eff4le0g	272	7	RICK	RICK	NNP
cord-265941-eff4le0g	272	8	and	and	CC
cord-265941-eff4le0g	272	9	CARDIAK	CARDIAK	NNP
cord-265941-eff4le0g	272	10	)	)	-RRB-
cord-265941-eff4le0g	272	11	is	be	VBZ
cord-265941-eff4le0g	272	12	an	an	DT
cord-265941-eff4le0g	272	13	essential	essential	JJ
cord-265941-eff4le0g	272	14	scaffold	scaffold	NN
cord-265941-eff4le0g	272	15	for	for	IN
cord-265941-eff4le0g	272	16	signal	signal	NN
cord-265941-eff4le0g	272	17	transduction	transduction	NN
cord-265941-eff4le0g	272	18	via	via	IN
cord-265941-eff4le0g	272	19	the	the	DT
cord-265941-eff4le0g	272	20	nucleotide	nucleotide	RB
cord-265941-eff4le0g	272	21	-	-	HYPH
cord-265941-eff4le0g	272	22	binding	bind	VBG
cord-265941-eff4le0g	272	23	oligomerization	oligomerization	NN
cord-265941-eff4le0g	272	24	domain	domain	NN
cord-265941-eff4le0g	272	25	(	(	-LRB-
cord-265941-eff4le0g	272	26	NOD	nod	NN
cord-265941-eff4le0g	272	27	)	)	-RRB-
cord-265941-eff4le0g	272	28	proteins	protein	NNS
cord-265941-eff4le0g	272	29	,	,	,
cord-265941-eff4le0g	272	30	NOD1	NOD1	NNP
cord-265941-eff4le0g	272	31	and	and	CC
cord-265941-eff4le0g	272	32	NOD2	NOD2	NNPS
cord-265941-eff4le0g	272	33	[	[	-LRB-
cord-265941-eff4le0g	272	34	137	137	CD
cord-265941-eff4le0g	272	35	]	]	-RRB-
cord-265941-eff4le0g	273	1	[	[	-LRB-
cord-265941-eff4le0g	273	2	138	138	CD
cord-265941-eff4le0g	273	3	]	]	-RRB-
cord-265941-eff4le0g	274	1	[	[	-LRB-
cord-265941-eff4le0g	274	2	139	139	CD
cord-265941-eff4le0g	274	3	]	]	-RRB-
cord-265941-eff4le0g	274	4	[	[	-LRB-
cord-265941-eff4le0g	274	5	140	140	CD
cord-265941-eff4le0g	274	6	]	]	-RRB-
cord-265941-eff4le0g	274	7	,	,	,
cord-265941-eff4le0g	274	8	and	and	CC
cord-265941-eff4le0g	274	9	is	be	VBZ
cord-265941-eff4le0g	274	10	thus	thus	RB
cord-265941-eff4le0g	274	11	frequently	frequently	RB
cord-265941-eff4le0g	274	12	implicated	implicate	VBN
cord-265941-eff4le0g	274	13	in	in	IN
cord-265941-eff4le0g	274	14	innate	innate	JJ
cord-265941-eff4le0g	274	15	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	274	16	responses	response	NNS
cord-265941-eff4le0g	274	17	to	to	IN
cord-265941-eff4le0g	274	18	pathogens	pathogen	NNS
cord-265941-eff4le0g	274	19	.	.	.
cord-265941-eff4le0g	275	1	NOD	NOD	NNP
cord-265941-eff4le0g	275	2	proteins	protein	NNS
cord-265941-eff4le0g	275	3	are	be	VBP
cord-265941-eff4le0g	275	4	cytosolic	cytosolic	JJ
cord-265941-eff4le0g	275	5	pattern	pattern	NN
cord-265941-eff4le0g	275	6	-	-	HYPH
cord-265941-eff4le0g	275	7	recognition	recognition	NN
cord-265941-eff4le0g	275	8	receptors	receptor	NNS
cord-265941-eff4le0g	275	9	(	(	-LRB-
cord-265941-eff4le0g	275	10	PRRs	PRRs	NNP
cord-265941-eff4le0g	275	11	)	)	-RRB-
cord-265941-eff4le0g	275	12	that	that	WDT
cord-265941-eff4le0g	275	13	activate	activate	VBP
cord-265941-eff4le0g	275	14	pro	pro	JJ
cord-265941-eff4le0g	275	15	-	-	JJ
cord-265941-eff4le0g	275	16	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	275	17	and	and	CC
cord-265941-eff4le0g	275	18	antimicrobial	antimicrobial	JJ
cord-265941-eff4le0g	275	19	responses	response	NNS
cord-265941-eff4le0g	275	20	when	when	WRB
cord-265941-eff4le0g	275	21	exposed	expose	VBN
cord-265941-eff4le0g	275	22	to	to	IN
cord-265941-eff4le0g	275	23	pathogen	pathogen	NN
cord-265941-eff4le0g	275	24	associated	associate	VBD
cord-265941-eff4le0g	275	25	molecular	molecular	JJ
cord-265941-eff4le0g	275	26	patterns	pattern	NNS
cord-265941-eff4le0g	275	27	(	(	-LRB-
cord-265941-eff4le0g	275	28	PAMPs	pamp	NNS
cord-265941-eff4le0g	275	29	)	)	-RRB-
cord-265941-eff4le0g	275	30	.	.	.
cord-265941-eff4le0g	276	1	NOD1	NOD1	NNP
cord-265941-eff4le0g	276	2	recognizes	recognize	VBZ
cord-265941-eff4le0g	276	3	Ɣ	ɣ	NN
cord-265941-eff4le0g	276	4	-	-	HYPH
cord-265941-eff4le0g	276	5	D	d	NN
cord-265941-eff4le0g	276	6	-	-	HYPH
cord-265941-eff4le0g	276	7	glutamyl	glutamyl	NN
cord-265941-eff4le0g	276	8	-	-	HYPH
cord-265941-eff4le0g	276	9	mesodiaminopimelic	mesodiaminopimelic	NN
cord-265941-eff4le0g	276	10	acid	acid	NN
cord-265941-eff4le0g	276	11	(	(	-LRB-
cord-265941-eff4le0g	276	12	iE	iE	NNP
cord-265941-eff4le0g	276	13	-	-	HYPH
cord-265941-eff4le0g	276	14	DAP	DAP	NNP
cord-265941-eff4le0g	276	15	)	)	-RRB-
cord-265941-eff4le0g	276	16	from	from	IN
cord-265941-eff4le0g	276	17	Gram	gram	NN
cord-265941-eff4le0g	276	18	-	-	HYPH
cord-265941-eff4le0g	276	19	negative	negative	JJ
cord-265941-eff4le0g	276	20	bacteria	bacteria	NNS
cord-265941-eff4le0g	276	21	and	and	CC
cord-265941-eff4le0g	276	22	some	some	DT
cord-265941-eff4le0g	276	23	Gram	gram	NN
cord-265941-eff4le0g	276	24	-	-	HYPH
cord-265941-eff4le0g	276	25	positive	positive	JJ
cord-265941-eff4le0g	276	26	bacteria	bacteria	NNS
cord-265941-eff4le0g	276	27	,	,	,
cord-265941-eff4le0g	276	28	whereas	whereas	IN
cord-265941-eff4le0g	276	29	NOD2	NOD2	NNP
cord-265941-eff4le0g	276	30	recognizes	recognize	VBZ
cord-265941-eff4le0g	276	31	a	a	DT
cord-265941-eff4le0g	276	32	conserved	conserved	JJ
cord-265941-eff4le0g	276	33	component	component	NN
cord-265941-eff4le0g	276	34	of	of	IN
cord-265941-eff4le0g	276	35	bacterial	bacterial	JJ
cord-265941-eff4le0g	276	36	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	276	37	(	(	-LRB-
cord-265941-eff4le0g	276	38	PGN	PGN	NNP
cord-265941-eff4le0g	276	39	)	)	-RRB-
cord-265941-eff4le0g	276	40	consisting	consist	VBG
cord-265941-eff4le0g	276	41	of	of	IN
cord-265941-eff4le0g	276	42	muramyl	muramyl	NNP
cord-265941-eff4le0g	276	43	dipeptide	dipeptide	NNP
cord-265941-eff4le0g	276	44	(	(	-LRB-
cord-265941-eff4le0g	276	45	MDP	MDP	NNP
cord-265941-eff4le0g	276	46	)	)	-RRB-
cord-265941-eff4le0g	276	47	from	from	IN
cord-265941-eff4le0g	276	48	both	both	CC
cord-265941-eff4le0g	276	49	Gram	Gram	NNP
cord-265941-eff4le0g	276	50	-	-	HYPH
cord-265941-eff4le0g	276	51	positive	positive	JJ
cord-265941-eff4le0g	276	52	and	and	CC
cord-265941-eff4le0g	276	53	Gram	gram	NN
cord-265941-eff4le0g	276	54	-	-	HYPH
cord-265941-eff4le0g	276	55	negative	negative	JJ
cord-265941-eff4le0g	276	56	bacteria	bacteria	NNS
cord-265941-eff4le0g	276	57	[	[	-LRB-
cord-265941-eff4le0g	276	58	141	141	CD
cord-265941-eff4le0g	276	59	]	]	-RRB-
cord-265941-eff4le0g	277	1	[	[	-LRB-
cord-265941-eff4le0g	277	2	142	142	CD
cord-265941-eff4le0g	277	3	]	]	-RRB-
cord-265941-eff4le0g	277	4	[	[	-LRB-
cord-265941-eff4le0g	277	5	143	143	CD
cord-265941-eff4le0g	277	6	]	]	-RRB-
cord-265941-eff4le0g	277	7	[	[	-LRB-
cord-265941-eff4le0g	277	8	144	144	CD
cord-265941-eff4le0g	277	9	]	]	-RRB-
cord-265941-eff4le0g	278	1	(	(	-LRB-
cord-265941-eff4le0g	278	2	Fig	Fig	NNP
cord-265941-eff4le0g	278	3	.	.	.
cord-265941-eff4le0g	278	4	3	3	CD
cord-265941-eff4le0g	278	5	)	)	-RRB-
cord-265941-eff4le0g	278	6	.	.	.
cord-265941-eff4le0g	279	1	These	these	DT
cord-265941-eff4le0g	279	2	stimulatory	stimulatory	JJ
cord-265941-eff4le0g	279	3	agents	agent	NNS
cord-265941-eff4le0g	279	4	are	be	VBP
cord-265941-eff4le0g	279	5	released	release	VBN
cord-265941-eff4le0g	279	6	from	from	IN
cord-265941-eff4le0g	279	7	bacteria	bacteria	NNS
cord-265941-eff4le0g	279	8	upon	upon	IN
cord-265941-eff4le0g	279	9	cell	cell	NN
cord-265941-eff4le0g	279	10	wall	wall	NN
cord-265941-eff4le0g	279	11	fragmentation	fragmentation	NN
cord-265941-eff4le0g	279	12	in	in	IN
cord-265941-eff4le0g	279	13	bacterial	bacterial	JJ
cord-265941-eff4le0g	279	14	killing	killing	NN
cord-265941-eff4le0g	279	15	,	,	,
cord-265941-eff4le0g	279	16	bacterial	bacterial	JJ
cord-265941-eff4le0g	279	17	division	division	NN
cord-265941-eff4le0g	279	18	,	,	,
cord-265941-eff4le0g	279	19	or	or	CC
cord-265941-eff4le0g	279	20	they	-PRON-	PRP
cord-265941-eff4le0g	279	21	can	can	MD
cord-265941-eff4le0g	279	22	be	be	VB
cord-265941-eff4le0g	279	23	co	co	VBN
cord-265941-eff4le0g	279	24	-	-	VBN
cord-265941-eff4le0g	279	25	injected	inject	VBN
cord-265941-eff4le0g	279	26	into	into	IN
cord-265941-eff4le0g	279	27	host	host	NN
cord-265941-eff4le0g	279	28	cells	cell	NNS
cord-265941-eff4le0g	279	29	with	with	IN
cord-265941-eff4le0g	279	30	virulence	virulence	NN
cord-265941-eff4le0g	279	31	proteins	protein	NNS
cord-265941-eff4le0g	279	32	by	by	IN
cord-265941-eff4le0g	279	33	bacterial	bacterial	JJ
cord-265941-eff4le0g	279	34	secretion	secretion	NN
cord-265941-eff4le0g	279	35	systems	system	NNS
cord-265941-eff4le0g	279	36	[	[	-LRB-
cord-265941-eff4le0g	279	37	145	145	CD
cord-265941-eff4le0g	279	38	]	]	-RRB-
cord-265941-eff4le0g	279	39	.	.	.
cord-265941-eff4le0g	280	1	Alternative	alternative	JJ
cord-265941-eff4le0g	280	2	mechanisms	mechanism	NNS
cord-265941-eff4le0g	280	3	of	of	IN
cord-265941-eff4le0g	280	4	NOD	NOD	NNP
cord-265941-eff4le0g	280	5	/	/	SYM
cord-265941-eff4le0g	280	6	RIPK2	ripk2	CD
cord-265941-eff4le0g	280	7	activation	activation	NN
cord-265941-eff4le0g	280	8	will	will	MD
cord-265941-eff4le0g	280	9	be	be	VB
cord-265941-eff4le0g	280	10	discussed	discuss	VBN
cord-265941-eff4le0g	280	11	in	in	IN
cord-265941-eff4le0g	280	12	context	context	NN
cord-265941-eff4le0g	280	13	within	within	IN
cord-265941-eff4le0g	280	14	the	the	DT
cord-265941-eff4le0g	280	15	review	review	NN
cord-265941-eff4le0g	280	16	.	.	.
cord-265941-eff4le0g	281	1	To	to	IN
cord-265941-eff4le0g	281	2	date	date	NN
cord-265941-eff4le0g	281	3	,	,	,
cord-265941-eff4le0g	281	4	much	much	JJ
cord-265941-eff4le0g	281	5	of	of	IN
cord-265941-eff4le0g	281	6	the	the	DT
cord-265941-eff4le0g	281	7	research	research	NN
cord-265941-eff4le0g	281	8	on	on	IN
cord-265941-eff4le0g	281	9	NOD1/	NOD1/	NNP
cord-265941-eff4le0g	282	1	NOD2	NOD2	NNP
cord-265941-eff4le0g	283	1	/RIPK2	/RIPK2	.
cord-265941-eff4le0g	284	1	signaling	signal	VBG
cord-265941-eff4le0g	284	2	mechanisms	mechanism	NNS
cord-265941-eff4le0g	284	3	has	have	VBZ
cord-265941-eff4le0g	284	4	relied	rely	VBN
cord-265941-eff4le0g	284	5	on	on	IN
cord-265941-eff4le0g	284	6	purified	purify	VBN
cord-265941-eff4le0g	284	7	PGN	PGN	NNP
cord-265941-eff4le0g	284	8	components	component	NNS
cord-265941-eff4le0g	284	9	as	as	IN
cord-265941-eff4le0g	284	10	a	a	DT
cord-265941-eff4le0g	284	11	cellular	cellular	JJ
cord-265941-eff4le0g	284	12	stimulus	stimulus	NN
cord-265941-eff4le0g	284	13	.	.	.
cord-265941-eff4le0g	285	1	This	this	DT
cord-265941-eff4le0g	285	2	has	have	VBZ
cord-265941-eff4le0g	285	3	been	be	VBN
cord-265941-eff4le0g	285	4	useful	useful	JJ
cord-265941-eff4le0g	285	5	for	for	IN
cord-265941-eff4le0g	285	6	the	the	DT
cord-265941-eff4le0g	285	7	identification	identification	NN
cord-265941-eff4le0g	285	8	of	of	IN
cord-265941-eff4le0g	285	9	cellular	cellular	JJ
cord-265941-eff4le0g	285	10	mechanisms	mechanism	NNS
cord-265941-eff4le0g	285	11	,	,	,
cord-265941-eff4le0g	285	12	however	however	RB
cord-265941-eff4le0g	285	13	can	can	MD
cord-265941-eff4le0g	285	14	have	have	VB
cord-265941-eff4le0g	285	15	limitations	limitation	NNS
cord-265941-eff4le0g	285	16	when	when	WRB
cord-265941-eff4le0g	285	17	considering	consider	VBG
cord-265941-eff4le0g	285	18	the	the	DT
cord-265941-eff4le0g	285	19	physiological	physiological	JJ
cord-265941-eff4le0g	285	20	role	role	NN
cord-265941-eff4le0g	285	21	of	of	IN
cord-265941-eff4le0g	285	22	signaling	signal	VBG
cord-265941-eff4le0g	285	23	mediators	mediator	NNS
cord-265941-eff4le0g	285	24	in	in	IN
cord-265941-eff4le0g	285	25	the	the	DT
cord-265941-eff4le0g	285	26	context	context	NN
cord-265941-eff4le0g	285	27	of	of	IN
cord-265941-eff4le0g	285	28	pathogen	pathogen	NN
cord-265941-eff4le0g	285	29	infection	infection	NN
cord-265941-eff4le0g	285	30	,	,	,
cord-265941-eff4le0g	285	31	especially	especially	RB
cord-265941-eff4le0g	285	32	when	when	WRB
cord-265941-eff4le0g	285	33	many	many	JJ
cord-265941-eff4le0g	285	34	pathogens	pathogen	NNS
cord-265941-eff4le0g	285	35	encode	encode	VBP
cord-265941-eff4le0g	285	36	virulence	virulence	NN
cord-265941-eff4le0g	285	37	factors	factor	NNS
cord-265941-eff4le0g	285	38	that	that	WDT
cord-265941-eff4le0g	285	39	can	can	MD
cord-265941-eff4le0g	285	40	inactivate	inactivate	VB
cord-265941-eff4le0g	285	41	innate	innate	JJ
cord-265941-eff4le0g	285	42	immune	immune	JJ
cord-265941-eff4le0g	285	43	signaling	signaling	NN
cord-265941-eff4le0g	285	44	.	.	.
cord-265941-eff4le0g	286	1	Although	although	IN
cord-265941-eff4le0g	286	2	many	many	JJ
cord-265941-eff4le0g	286	3	studies	study	NNS
cord-265941-eff4le0g	286	4	have	have	VBP
cord-265941-eff4le0g	286	5	assessed	assess	VBN
cord-265941-eff4le0g	286	6	mechanisms	mechanism	NNS
cord-265941-eff4le0g	286	7	of	of	IN
cord-265941-eff4le0g	286	8	NOD	nod	NN
cord-265941-eff4le0g	286	9	signaling	signaling	NN
cord-265941-eff4le0g	286	10	in	in	IN
cord-265941-eff4le0g	286	11	bacterial	bacterial	JJ
cord-265941-eff4le0g	286	12	control	control	NN
cord-265941-eff4le0g	286	13	,	,	,
cord-265941-eff4le0g	286	14	especially	especially	RB
cord-265941-eff4le0g	286	15	in	in	IN
cord-265941-eff4le0g	286	16	the	the	DT
cord-265941-eff4le0g	286	17	context	context	NN
cord-265941-eff4le0g	286	18	of	of	IN
cord-265941-eff4le0g	286	19	autophagy	autophagy	NN
cord-265941-eff4le0g	286	20	,	,	,
cord-265941-eff4le0g	286	21	this	this	DT
cord-265941-eff4le0g	286	22	review	review	NN
cord-265941-eff4le0g	286	23	will	will	MD
cord-265941-eff4le0g	286	24	focus	focus	VB
cord-265941-eff4le0g	286	25	on	on	IN
cord-265941-eff4le0g	286	26	studies	study	NNS
cord-265941-eff4le0g	286	27	with	with	IN
cord-265941-eff4le0g	286	28	direct	direct	JJ
cord-265941-eff4le0g	286	29	experimental	experimental	JJ
cord-265941-eff4le0g	286	30	evidence	evidence	NN
cord-265941-eff4le0g	286	31	of	of	IN
cord-265941-eff4le0g	286	32	RIPK2	ripk2	DT
cord-265941-eff4le0g	286	33	involvement	involvement	NN
cord-265941-eff4le0g	286	34	,	,	,
cord-265941-eff4le0g	286	35	and	and	CC
cord-265941-eff4le0g	286	36	where	where	WRB
cord-265941-eff4le0g	286	37	live	live	JJ
cord-265941-eff4le0g	286	38	bacterial	bacterial	JJ
cord-265941-eff4le0g	286	39	agents	agent	NNS
cord-265941-eff4le0g	286	40	have	have	VBP
cord-265941-eff4le0g	286	41	been	be	VBN
cord-265941-eff4le0g	286	42	utilised	utilise	VBN
cord-265941-eff4le0g	286	43	.	.	.
cord-265941-eff4le0g	287	1	Fig	Fig	NNP
cord-265941-eff4le0g	287	2	.	.	.
cord-265941-eff4le0g	288	1	3	3	LS
cord-265941-eff4le0g	288	2	.	.	.
cord-265941-eff4le0g	289	1	RIPK2	ripk2	DT
cord-265941-eff4le0g	289	2	regulation	regulation	NN
cord-265941-eff4le0g	289	3	of	of	IN
cord-265941-eff4le0g	289	4	NOD1	NOD1	NNP
cord-265941-eff4le0g	289	5	and	and	CC
cord-265941-eff4le0g	289	6	NOD2	NOD2	NNP
cord-265941-eff4le0g	289	7	signaling	signal	VBG
cord-265941-eff4le0g	289	8	in	in	IN
cord-265941-eff4le0g	289	9	response	response	NN
cord-265941-eff4le0g	289	10	to	to	IN
cord-265941-eff4le0g	289	11	PAMP	PAMP	NNP
cord-265941-eff4le0g	289	12	sensing	sensing	NN
cord-265941-eff4le0g	289	13	.	.	.
cord-265941-eff4le0g	290	1	Upon	upon	IN
cord-265941-eff4le0g	290	2	activation	activation	NN
cord-265941-eff4le0g	290	3	by	by	IN
cord-265941-eff4le0g	290	4	bacterial	bacterial	JJ
cord-265941-eff4le0g	290	5	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	290	6	components	component	NNS
cord-265941-eff4le0g	290	7	,	,	,
cord-265941-eff4le0g	290	8	NOD1	NOD1	NNP
cord-265941-eff4le0g	290	9	and	and	CC
cord-265941-eff4le0g	290	10	NOD2	NOD2	NNP
cord-265941-eff4le0g	290	11	oligomerize	oligomerize	NNP
cord-265941-eff4le0g	290	12	and	and	CC
cord-265941-eff4le0g	290	13	interact	interact	VB
cord-265941-eff4le0g	290	14	with	with	IN
cord-265941-eff4le0g	290	15	RIPK2	ripk2	XX
cord-265941-eff4le0g	290	16	via	via	IN
cord-265941-eff4le0g	290	17	homotypic	homotypic	JJ
cord-265941-eff4le0g	290	18	CARD	card	NN
cord-265941-eff4le0g	290	19	-	-	HYPH
cord-265941-eff4le0g	290	20	CARD	card	NN
cord-265941-eff4le0g	290	21	interactions	interaction	NNS
cord-265941-eff4le0g	290	22	[	[	-LRB-
cord-265941-eff4le0g	290	23	137	137	CD
cord-265941-eff4le0g	290	24	]	]	-RRB-
cord-265941-eff4le0g	290	25	.	.	.
cord-265941-eff4le0g	291	1	Once	once	RB
cord-265941-eff4le0g	291	2	engaged	engage	VBN
cord-265941-eff4le0g	291	3	,	,	,
cord-265941-eff4le0g	291	4	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	291	5	is	be	VBZ
cord-265941-eff4le0g	291	6	activated	activate	VBN
cord-265941-eff4le0g	291	7	by	by	IN
cord-265941-eff4le0g	291	8	autophosphorylation	autophosphorylation	NN
cord-265941-eff4le0g	291	9	,	,	,
cord-265941-eff4le0g	291	10	then	then	RB
cord-265941-eff4le0g	291	11	ubiquitylated	ubiquitylate	VBN
cord-265941-eff4le0g	291	12	by	by	IN
cord-265941-eff4le0g	291	13	E3	E3	NNP
cord-265941-eff4le0g	291	14	ligases	ligase	NNS
cord-265941-eff4le0g	291	15	including	include	VBG
cord-265941-eff4le0g	291	16	XIAP	XIAP	NNP
cord-265941-eff4le0g	291	17	and	and	CC
cord-265941-eff4le0g	291	18	LUBAC	LUBAC	NNP
cord-265941-eff4le0g	291	19	,	,	,
cord-265941-eff4le0g	291	20	which	which	WDT
cord-265941-eff4le0g	291	21	further	further	RB
cord-265941-eff4le0g	291	22	activates	activate	VBZ
cord-265941-eff4le0g	291	23	both	both	DT
cord-265941-eff4le0g	291	24	NF	nf	NN
cord-265941-eff4le0g	291	25	-	-	HYPH
cord-265941-eff4le0g	291	26	κB	κB	NNP
cord-265941-eff4le0g	291	27	and	and	CC
cord-265941-eff4le0g	291	28	MAPK	MAPK	NNP
cord-265941-eff4le0g	291	29	pathways	pathway	NNS
cord-265941-eff4le0g	291	30	and	and	CC
cord-265941-eff4le0g	291	31	promotes	promote	VBZ
cord-265941-eff4le0g	291	32	pro	pro	JJ
cord-265941-eff4le0g	291	33	-	-	JJ
cord-265941-eff4le0g	291	34	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	291	35	cytokine	cytokine	NN
cord-265941-eff4le0g	291	36	production	production	NN
cord-265941-eff4le0g	291	37	[	[	-LRB-
cord-265941-eff4le0g	291	38	146	146	CD
cord-265941-eff4le0g	291	39	]	]	-RRB-
cord-265941-eff4le0g	291	40	.	.	.
cord-265941-eff4le0g	292	1	Alternatively	alternatively	RB
cord-265941-eff4le0g	292	2	,	,	,
cord-265941-eff4le0g	292	3	TRAF3	TRAF3	NNP
cord-265941-eff4le0g	292	4	can	can	MD
cord-265941-eff4le0g	292	5	interact	interact	VB
cord-265941-eff4le0g	292	6	with	with	IN
cord-265941-eff4le0g	292	7	RIPK2	RIPK2	HYPH
cord-265941-eff4le0g	292	8	following	follow	VBG
cord-265941-eff4le0g	292	9	NOD1/2	NOD1/2	NNP
cord-265941-eff4le0g	292	10	ligation	ligation	NN
cord-265941-eff4le0g	292	11	,	,	,
cord-265941-eff4le0g	292	12	redirecting	redirect	VBG
cord-265941-eff4le0g	292	13	signaling	signal	VBG
cord-265941-eff4le0g	292	14	to	to	IN
cord-265941-eff4le0g	292	15	TBK1	TBK1	NNP
cord-265941-eff4le0g	292	16	and	and	CC
cord-265941-eff4le0g	292	17	IKKε	IKKε	NNS
cord-265941-eff4le0g	292	18	to	to	TO
cord-265941-eff4le0g	292	19	promote	promote	VB
cord-265941-eff4le0g	292	20	downstream	downstream	JJ
cord-265941-eff4le0g	292	21	IFN	IFN	NNP
cord-265941-eff4le0g	292	22	production	production	NN
cord-265941-eff4le0g	292	23	[	[	-LRB-
cord-265941-eff4le0g	292	24	147	147	CD
cord-265941-eff4le0g	292	25	]	]	-RRB-
cord-265941-eff4le0g	292	26	.	.	.
cord-265941-eff4le0g	293	1	Other	other	JJ
cord-265941-eff4le0g	293	2	roles	role	NNS
cord-265941-eff4le0g	293	3	of	of	IN
cord-265941-eff4le0g	293	4	RIPK2	ripk2	DT
cord-265941-eff4le0g	293	5	include	include	VBP
cord-265941-eff4le0g	293	6	mediating	mediate	VBG
cord-265941-eff4le0g	293	7	interactions	interaction	NNS
cord-265941-eff4le0g	293	8	between	between	IN
cord-265941-eff4le0g	293	9	NOD1/2	nod1/2	NN
cord-265941-eff4le0g	293	10	and	and	CC
cord-265941-eff4le0g	293	11	key	key	JJ
cord-265941-eff4le0g	293	12	autophagy	autophagy	NN
cord-265941-eff4le0g	293	13	protein	protein	NN
cord-265941-eff4le0g	293	14	ATG16L1	ATG16L1	NNS
cord-265941-eff4le0g	293	15	,	,	,
cord-265941-eff4le0g	293	16	which	which	WDT
cord-265941-eff4le0g	293	17	enables	enable	VBZ
cord-265941-eff4le0g	293	18	autophagic	autophagic	JJ
cord-265941-eff4le0g	293	19	bacterial	bacterial	JJ
cord-265941-eff4le0g	293	20	clearance	clearance	NN
cord-265941-eff4le0g	293	21	following	follow	VBG
cord-265941-eff4le0g	293	22	NOD	NOD	NNP
cord-265941-eff4le0g	293	23	sensing	sensing	NN
cord-265941-eff4le0g	293	24	of	of	IN
cord-265941-eff4le0g	293	25	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	293	26	or	or	CC
cord-265941-eff4le0g	293	27	bacterial	bacterial	JJ
cord-265941-eff4le0g	293	28	OMVs	omv	NNS
cord-265941-eff4le0g	293	29	[	[	-LRB-
cord-265941-eff4le0g	293	30	148	148	CD
cord-265941-eff4le0g	293	31	]	]	-RRB-
cord-265941-eff4le0g	294	1	[	[	-LRB-
cord-265941-eff4le0g	294	2	149	149	CD
cord-265941-eff4le0g	294	3	]	]	-RRB-
cord-265941-eff4le0g	294	4	[	[	-LRB-
cord-265941-eff4le0g	294	5	150	150	CD
cord-265941-eff4le0g	294	6	]	]	-RRB-
cord-265941-eff4le0g	294	7	.	.	.
cord-265941-eff4le0g	295	1	Virulence	virulence	NN
cord-265941-eff4le0g	295	2	factors	factor	NNS
cord-265941-eff4le0g	295	3	that	that	WDT
cord-265941-eff4le0g	295	4	interact	interact	VBP
cord-265941-eff4le0g	295	5	with	with	IN
cord-265941-eff4le0g	295	6	these	these	DT
cord-265941-eff4le0g	295	7	pathways	pathway	NNS
cord-265941-eff4le0g	295	8	are	be	VBP
cord-265941-eff4le0g	295	9	indicated	indicate	VBN
cord-265941-eff4le0g	295	10	,	,	,
cord-265941-eff4le0g	295	11	and	and	CC
cord-265941-eff4le0g	295	12	have	have	VBP
cord-265941-eff4le0g	295	13	been	be	VBN
cord-265941-eff4le0g	295	14	discussed	discuss	VBN
cord-265941-eff4le0g	295	15	in	in	IN
cord-265941-eff4le0g	295	16	the	the	DT
cord-265941-eff4le0g	295	17	main	main	JJ
cord-265941-eff4le0g	295	18	body	body	NN
cord-265941-eff4le0g	295	19	of	of	IN
cord-265941-eff4le0g	295	20	the	the	DT
cord-265941-eff4le0g	295	21	text	text	NN
cord-265941-eff4le0g	295	22	.	.	.
cord-265941-eff4le0g	296	1	Some	some	DT
cord-265941-eff4le0g	296	2	of	of	IN
cord-265941-eff4le0g	296	3	the	the	DT
cord-265941-eff4le0g	296	4	earliest	early	JJS
cord-265941-eff4le0g	296	5	studies	study	NNS
cord-265941-eff4le0g	296	6	that	that	WDT
cord-265941-eff4le0g	296	7	characterised	characterise	VBD
cord-265941-eff4le0g	296	8	the	the	DT
cord-265941-eff4le0g	296	9	role	role	NN
cord-265941-eff4le0g	296	10	of	of	IN
cord-265941-eff4le0g	296	11	RIPK2	ripk2	XX
cord-265941-eff4le0g	296	12	in	in	IN
cord-265941-eff4le0g	296	13	host	host	NN
cord-265941-eff4le0g	296	14	responses	response	NNS
cord-265941-eff4le0g	296	15	to	to	IN
cord-265941-eff4le0g	296	16	infections	infection	NNS
cord-265941-eff4le0g	296	17	utilised	utilise	VBN
cord-265941-eff4le0g	296	18	L.	L.	NNP
cord-265941-eff4le0g	296	19	monocytogenes	monocytogenes	NNP
cord-265941-eff4le0g	296	20	,	,	,
cord-265941-eff4le0g	296	21	the	the	DT
cord-265941-eff4le0g	296	22	causative	causative	JJ
cord-265941-eff4le0g	296	23	agent	agent	NN
cord-265941-eff4le0g	296	24	of	of	IN
cord-265941-eff4le0g	296	25	listeriosis	listeriosis	NN
cord-265941-eff4le0g	296	26	.	.	.
cord-265941-eff4le0g	297	1	Initial	initial	JJ
cord-265941-eff4le0g	297	2	studies	study	NNS
cord-265941-eff4le0g	297	3	showed	show	VBD
cord-265941-eff4le0g	297	4	macrophages	macrophage	NNS
cord-265941-eff4le0g	297	5	from	from	IN
cord-265941-eff4le0g	297	6	Ripk2	Ripk2	NNP
cord-265941-eff4le0g	297	7	−	−	NNP
cord-265941-eff4le0g	298	1	/−	/−	.
cord-265941-eff4le0g	299	1	mice	mouse	NNS
cord-265941-eff4le0g	299	2	were	be	VBD
cord-265941-eff4le0g	299	3	defective	defective	JJ
cord-265941-eff4le0g	299	4	in	in	IN
cord-265941-eff4le0g	300	1	NF	NF	NNP
cord-265941-eff4le0g	300	2	-	-	HYPH
cord-265941-eff4le0g	300	3	κB	κB	NNP
cord-265941-eff4le0g	300	4	signaling	signal	VBG
cord-265941-eff4le0g	300	5	and	and	CC
cord-265941-eff4le0g	300	6	produced	produce	VBD
cord-265941-eff4le0g	300	7	significantly	significantly	RB
cord-265941-eff4le0g	300	8	less	less	RBR
cord-265941-eff4le0g	300	9	pro	pro	JJ
cord-265941-eff4le0g	300	10	-	-	JJ
cord-265941-eff4le0g	300	11	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	300	12	cytokines	cytokine	NNS
cord-265941-eff4le0g	300	13	than	than	IN
cord-265941-eff4le0g	300	14	WT	wt	NN
cord-265941-eff4le0g	300	15	macrophages	macrophage	NNS
cord-265941-eff4le0g	300	16	following	follow	VBG
cord-265941-eff4le0g	300	17	infection	infection	NN
cord-265941-eff4le0g	300	18	[	[	-LRB-
cord-265941-eff4le0g	300	19	137	137	CD
cord-265941-eff4le0g	300	20	,	,	,
cord-265941-eff4le0g	300	21	151	151	CD
cord-265941-eff4le0g	300	22	]	]	-RRB-
cord-265941-eff4le0g	300	23	.	.	.
cord-265941-eff4le0g	301	1	Furthermore	furthermore	RB
cord-265941-eff4le0g	301	2	,	,	,
cord-265941-eff4le0g	301	3	Ripk2	Ripk2	NNP
cord-265941-eff4le0g	301	4	−	−	NNP
cord-265941-eff4le0g	301	5	/−	/−	.
cord-265941-eff4le0g	302	1	mice	mouse	NNS
cord-265941-eff4le0g	302	2	were	be	VBD
cord-265941-eff4le0g	302	3	unable	unable	JJ
cord-265941-eff4le0g	302	4	to	to	TO
cord-265941-eff4le0g	302	5	control	control	VB
cord-265941-eff4le0g	302	6	L.	L.	NNP
cord-265941-eff4le0g	302	7	monocytogenes	monocytogenes	NN
cord-265941-eff4le0g	302	8	infection	infection	NN
cord-265941-eff4le0g	302	9	due	due	JJ
cord-265941-eff4le0g	302	10	to	to	IN
cord-265941-eff4le0g	302	11	decreased	decrease	VBN
cord-265941-eff4le0g	302	12	NF	nf	NN
cord-265941-eff4le0g	302	13	-	-	HYPH
cord-265941-eff4le0g	302	14	κB	κb	CD
cord-265941-eff4le0g	302	15	activation	activation	NN
cord-265941-eff4le0g	302	16	,	,	,
cord-265941-eff4le0g	302	17	and	and	CC
cord-265941-eff4le0g	302	18	impaired	impair	VBD
cord-265941-eff4le0g	302	19	IFN	IFN	NNP
cord-265941-eff4le0g	302	20	Ɣ	Ɣ	NNP
cord-265941-eff4le0g	302	21	production	production	NN
cord-265941-eff4le0g	302	22	in	in	IN
cord-265941-eff4le0g	302	23	T	T	NNP
cord-265941-eff4le0g	302	24	helper	helper	NN
cord-265941-eff4le0g	302	25	1	1	CD
cord-265941-eff4le0g	302	26	(	(	-LRB-
cord-265941-eff4le0g	302	27	Th1	Th1	NNP
cord-265941-eff4le0g	302	28	)	)	-RRB-
cord-265941-eff4le0g	302	29	and	and	CC
cord-265941-eff4le0g	302	30	natural	natural	JJ
cord-265941-eff4le0g	302	31	killer	killer	NN
cord-265941-eff4le0g	302	32	(	(	-LRB-
cord-265941-eff4le0g	302	33	NK	NK	NNP
cord-265941-eff4le0g	302	34	)	)	-RRB-
cord-265941-eff4le0g	302	35	cells	cell	NNS
cord-265941-eff4le0g	302	36	.	.	.
cord-265941-eff4le0g	303	1	Overall	overall	RB
cord-265941-eff4le0g	303	2	this	this	DT
cord-265941-eff4le0g	303	3	suggests	suggest	VBZ
cord-265941-eff4le0g	303	4	that	that	IN
cord-265941-eff4le0g	303	5	RIPK2	RIPK2	HYPH
cord-265941-eff4le0g	303	6	plays	play	VBZ
cord-265941-eff4le0g	303	7	an	an	DT
cord-265941-eff4le0g	303	8	important	important	JJ
cord-265941-eff4le0g	303	9	role	role	NN
cord-265941-eff4le0g	303	10	in	in	IN
cord-265941-eff4le0g	303	11	both	both	DT
cord-265941-eff4le0g	303	12	innate	innate	JJ
cord-265941-eff4le0g	303	13	and	and	CC
cord-265941-eff4le0g	303	14	adaptive	adaptive	JJ
cord-265941-eff4le0g	303	15	immunity	immunity	NN
cord-265941-eff4le0g	303	16	to	to	IN
cord-265941-eff4le0g	303	17	infection	infection	NN
cord-265941-eff4le0g	303	18	[	[	-LRB-
cord-265941-eff4le0g	303	19	137	137	CD
cord-265941-eff4le0g	303	20	,	,	,
cord-265941-eff4le0g	303	21	151	151	CD
cord-265941-eff4le0g	303	22	]	]	-RRB-
cord-265941-eff4le0g	303	23	,	,	,
cord-265941-eff4le0g	303	24	and	and	CC
cord-265941-eff4le0g	303	25	that	that	IN
cord-265941-eff4le0g	303	26	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	303	27	was	be	VBD
cord-265941-eff4le0g	303	28	mediating	mediate	VBG
cord-265941-eff4le0g	303	29	these	these	DT
cord-265941-eff4le0g	303	30	responses	response	NNS
cord-265941-eff4le0g	303	31	via	via	IN
cord-265941-eff4le0g	303	32	NOD1/2	NOD1/2	NNP
cord-265941-eff4le0g	304	1	and	and	CC
cord-265941-eff4le0g	304	2	not	not	RB
cord-265941-eff4le0g	304	3	directly	directly	RB
cord-265941-eff4le0g	304	4	via	via	IN
cord-265941-eff4le0g	304	5	TLR	TLR	NNP
cord-265941-eff4le0g	304	6	activation	activation	NN
cord-265941-eff4le0g	304	7	[	[	-LRB-
cord-265941-eff4le0g	304	8	140	140	CD
cord-265941-eff4le0g	304	9	]	]	-RRB-
cord-265941-eff4le0g	304	10	.	.	.
cord-265941-eff4le0g	305	1	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	305	2	has	have	VBZ
cord-265941-eff4le0g	305	3	since	since	IN
cord-265941-eff4le0g	305	4	been	be	VBN
cord-265941-eff4le0g	305	5	shown	show	VBN
cord-265941-eff4le0g	305	6	to	to	TO
cord-265941-eff4le0g	305	7	play	play	VB
cord-265941-eff4le0g	305	8	a	a	DT
cord-265941-eff4le0g	305	9	role	role	NN
cord-265941-eff4le0g	305	10	in	in	IN
cord-265941-eff4le0g	305	11	controlling	control	VBG
cord-265941-eff4le0g	305	12	a	a	DT
cord-265941-eff4le0g	305	13	diverse	diverse	JJ
cord-265941-eff4le0g	305	14	array	array	NN
cord-265941-eff4le0g	305	15	of	of	IN
cord-265941-eff4le0g	305	16	bacterial	bacterial	JJ
cord-265941-eff4le0g	305	17	pathogens	pathogen	NNS
cord-265941-eff4le0g	305	18	,	,	,
cord-265941-eff4le0g	305	19	particularly	particularly	RB
cord-265941-eff4le0g	305	20	those	those	DT
cord-265941-eff4le0g	305	21	with	with	IN
cord-265941-eff4le0g	305	22	an	an	DT
cord-265941-eff4le0g	305	23	intracellular	intracellular	JJ
cord-265941-eff4le0g	305	24	lifestyle	lifestyle	NN
cord-265941-eff4le0g	305	25	(	(	-LRB-
cord-265941-eff4le0g	305	26	Table	table	NN
cord-265941-eff4le0g	305	27	1	1	CD
cord-265941-eff4le0g	305	28	)	)	-RRB-
cord-265941-eff4le0g	305	29	.	.	.
cord-265941-eff4le0g	306	1	Single	single	JJ
cord-265941-eff4le0g	306	2	nucleotide	nucleotide	JJ
cord-265941-eff4le0g	306	3	polymorphisms	polymorphism	NNS
cord-265941-eff4le0g	306	4	(	(	-LRB-
cord-265941-eff4le0g	306	5	SNPs	SNPs	NNP
cord-265941-eff4le0g	306	6	)	)	-RRB-
cord-265941-eff4le0g	307	1	in	in	IN
cord-265941-eff4le0g	307	2	RIPK2	ripk2	DT
cord-265941-eff4le0g	307	3	increase	increase	NN
cord-265941-eff4le0g	307	4	susceptibility	susceptibility	NN
cord-265941-eff4le0g	307	5	to	to	IN
cord-265941-eff4le0g	307	6	mycobacterial	mycobacterial	JJ
cord-265941-eff4le0g	307	7	infections	infection	NNS
cord-265941-eff4le0g	307	8	,	,	,
cord-265941-eff4le0g	307	9	for	for	IN
cord-265941-eff4le0g	307	10	example	example	NN
cord-265941-eff4le0g	307	11	,	,	,
cord-265941-eff4le0g	307	12	multibacillary	multibacillary	JJ
cord-265941-eff4le0g	307	13	leprosy	leprosy	NN
cord-265941-eff4le0g	307	14	caused	cause	VBN
cord-265941-eff4le0g	307	15	by	by	IN
cord-265941-eff4le0g	307	16	M.	M.	NNP
cord-265941-eff4le0g	307	17	leprae	leprae	NNP
cord-265941-eff4le0g	307	18	[	[	-LRB-
cord-265941-eff4le0g	307	19	152	152	CD
cord-265941-eff4le0g	307	20	]	]	-RRB-
cord-265941-eff4le0g	307	21	,	,	,
cord-265941-eff4le0g	307	22	and	and	CC
cord-265941-eff4le0g	307	23	M.	M.	NNP
cord-265941-eff4le0g	307	24	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	307	25	infections	infection	NNS
cord-265941-eff4le0g	307	26	within	within	IN
cord-265941-eff4le0g	307	27	the	the	DT
cord-265941-eff4le0g	307	28	Western	western	JJ
cord-265941-eff4le0g	307	29	Chinese	chinese	JJ
cord-265941-eff4le0g	307	30	Han	Han	NNP
cord-265941-eff4le0g	307	31	population	population	NN
cord-265941-eff4le0g	307	32	[	[	-LRB-
cord-265941-eff4le0g	307	33	153	153	CD
cord-265941-eff4le0g	307	34	]	]	-RRB-
cord-265941-eff4le0g	307	35	.	.	.
cord-265941-eff4le0g	308	1	Although	although	IN
cord-265941-eff4le0g	308	2	the	the	DT
cord-265941-eff4le0g	308	3	mechanisms	mechanism	NNS
cord-265941-eff4le0g	308	4	underlying	underlie	VBG
cord-265941-eff4le0g	308	5	susceptibility	susceptibility	NN
cord-265941-eff4le0g	308	6	are	be	VBP
cord-265941-eff4le0g	308	7	unclear	unclear	JJ
cord-265941-eff4le0g	308	8	,	,	,
cord-265941-eff4le0g	308	9	M.	M.	NNP
cord-265941-eff4le0g	308	10	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	308	11	activates	activate	VBZ
cord-265941-eff4le0g	308	12	NOD2	NOD2	NNP
cord-265941-eff4le0g	308	13	/	/	SYM
cord-265941-eff4le0g	308	14	RIPK2	ripk2	XX
cord-265941-eff4le0g	308	15	,	,	,
cord-265941-eff4le0g	308	16	which	which	WDT
cord-265941-eff4le0g	308	17	stimulates	stimulate	VBZ
cord-265941-eff4le0g	308	18	the	the	DT
cord-265941-eff4le0g	308	19	activity	activity	NN
cord-265941-eff4le0g	308	20	of	of	IN
cord-265941-eff4le0g	308	21	IRF5	IRF5	NNP
cord-265941-eff4le0g	308	22	to	to	TO
cord-265941-eff4le0g	308	23	induce	induce	VB
cord-265941-eff4le0g	308	24	transcription	transcription	NN
cord-265941-eff4le0g	308	25	of	of	IN
cord-265941-eff4le0g	308	26	type	type	NN
cord-265941-eff4le0g	308	27	I	-PRON-	PRP
cord-265941-eff4le0g	308	28	IFNs	ifns	VBP
cord-265941-eff4le0g	308	29	[	[	-LRB-
cord-265941-eff4le0g	308	30	147	147	CD
cord-265941-eff4le0g	308	31	]	]	-RRB-
cord-265941-eff4le0g	308	32	.	.	.
cord-265941-eff4le0g	309	1	Furthermore	furthermore	RB
cord-265941-eff4le0g	309	2	,	,	,
cord-265941-eff4le0g	309	3	IFNγ	IFNγ	NNS
cord-265941-eff4le0g	309	4	production	production	NN
cord-265941-eff4le0g	309	5	by	by	IN
cord-265941-eff4le0g	309	6	Th1	th1	NN
cord-265941-eff4le0g	309	7	cells	cell	NNS
cord-265941-eff4le0g	309	8	induces	induce	VBZ
cord-265941-eff4le0g	309	9	macrophage	macrophage	NN
cord-265941-eff4le0g	309	10	maturation	maturation	NN
cord-265941-eff4le0g	309	11	and	and	CC
cord-265941-eff4le0g	309	12	anti	anti	JJ
cord-265941-eff4le0g	309	13	-	-	JJ
cord-265941-eff4le0g	309	14	mycobacterial	mycobacterial	JJ
cord-265941-eff4le0g	309	15	molecules	molecule	NNS
cord-265941-eff4le0g	309	16	important	important	JJ
cord-265941-eff4le0g	309	17	for	for	IN
cord-265941-eff4le0g	309	18	resistance	resistance	NN
cord-265941-eff4le0g	309	19	against	against	IN
cord-265941-eff4le0g	309	20	mycobacterial	mycobacterial	JJ
cord-265941-eff4le0g	309	21	infections	infection	NNS
cord-265941-eff4le0g	309	22	[	[	-LRB-
cord-265941-eff4le0g	309	23	154	154	CD
cord-265941-eff4le0g	309	24	,	,	,
cord-265941-eff4le0g	309	25	155	155	CD
cord-265941-eff4le0g	309	26	]	]	-RRB-
cord-265941-eff4le0g	309	27	.	.	.
cord-265941-eff4le0g	310	1	Zhang	Zhang	NNP
cord-265941-eff4le0g	310	2	et	et	NNP
cord-265941-eff4le0g	310	3	al	al	NNP
cord-265941-eff4le0g	310	4	.	.	.
cord-265941-eff4le0g	311	1	[	[	-LRB-
cord-265941-eff4le0g	311	2	152	152	CD
cord-265941-eff4le0g	311	3	]	]	-RRB-
cord-265941-eff4le0g	311	4	suggested	suggest	VBD
cord-265941-eff4le0g	311	5	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	311	6	and	and	CC
cord-265941-eff4le0g	311	7	NOD2	NOD2	NNPS
cord-265941-eff4le0g	311	8	may	may	MD
cord-265941-eff4le0g	311	9	regulate	regulate	VB
cord-265941-eff4le0g	311	10	IFNγ	IFNγ	NNS
cord-265941-eff4le0g	311	11	which	which	WDT
cord-265941-eff4le0g	311	12	could	could	MD
cord-265941-eff4le0g	311	13	explain	explain	VB
cord-265941-eff4le0g	311	14	increased	increase	VBN
cord-265941-eff4le0g	311	15	susceptibility	susceptibility	NN
cord-265941-eff4le0g	311	16	to	to	IN
cord-265941-eff4le0g	311	17	mycobacterial	mycobacterial	JJ
cord-265941-eff4le0g	311	18	infections	infection	NNS
cord-265941-eff4le0g	311	19	in	in	IN
cord-265941-eff4le0g	311	20	those	those	DT
cord-265941-eff4le0g	311	21	with	with	IN
cord-265941-eff4le0g	311	22	RIPK2	ripk2	CD
cord-265941-eff4le0g	311	23	polymorphisms	polymorphism	NNS
cord-265941-eff4le0g	311	24	.	.	.
cord-265941-eff4le0g	312	1	Streptococcus	streptococcus	NN
cord-265941-eff4le0g	312	2	pneumoniae	pneumoniae	NN
cord-265941-eff4le0g	312	3	(	(	-LRB-
cord-265941-eff4le0g	312	4	pneumococcus	pneumococcus	NNP
cord-265941-eff4le0g	312	5	)	)	-RRB-
cord-265941-eff4le0g	312	6	is	be	VBZ
cord-265941-eff4le0g	312	7	a	a	DT
cord-265941-eff4le0g	312	8	an	an	DT
cord-265941-eff4le0g	312	9	opportunistic	opportunistic	JJ
cord-265941-eff4le0g	312	10	pathogen	pathogen	NN
cord-265941-eff4le0g	312	11	associated	associate	VBN
cord-265941-eff4le0g	312	12	with	with	IN
cord-265941-eff4le0g	312	13	pneumonia	pneumonia	NN
cord-265941-eff4le0g	312	14	,	,	,
cord-265941-eff4le0g	312	15	ear	ear	NN
cord-265941-eff4le0g	312	16	infections	infection	NNS
cord-265941-eff4le0g	312	17	,	,	,
cord-265941-eff4le0g	312	18	sinus	sinus	NN
cord-265941-eff4le0g	312	19	infections	infection	NNS
cord-265941-eff4le0g	312	20	,	,	,
cord-265941-eff4le0g	312	21	meningitis	meningitis	NN
cord-265941-eff4le0g	312	22	and	and	CC
cord-265941-eff4le0g	312	23	bacteremia	bacteremia	NN
cord-265941-eff4le0g	312	24	[	[	-LRB-
cord-265941-eff4le0g	312	25	156	156	CD
cord-265941-eff4le0g	312	26	]	]	-RRB-
cord-265941-eff4le0g	312	27	.	.	.
cord-265941-eff4le0g	313	1	NOD2	NOD2	NNP
cord-265941-eff4le0g	313	2	/	/	SYM
cord-265941-eff4le0g	313	3	RIPK2	ripk2	CC
cord-265941-eff4le0g	313	4	are	be	VBP
cord-265941-eff4le0g	313	5	critical	critical	JJ
cord-265941-eff4le0g	313	6	for	for	IN
cord-265941-eff4le0g	313	7	anti	anti	JJ
cord-265941-eff4le0g	313	8	-	-	JJ
cord-265941-eff4le0g	313	9	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	313	10	signaling	signaling	NN
cord-265941-eff4le0g	313	11	in	in	IN
cord-265941-eff4le0g	313	12	response	response	NN
cord-265941-eff4le0g	313	13	to	to	IN
cord-265941-eff4le0g	313	14	the	the	DT
cord-265941-eff4le0g	313	15	purified	purify	VBN
cord-265941-eff4le0g	313	16	pneumococcal	pneumococcal	JJ
cord-265941-eff4le0g	313	17	cell	cell	NN
cord-265941-eff4le0g	313	18	wall	wall	NN
cord-265941-eff4le0g	313	19	(	(	-LRB-
cord-265941-eff4le0g	313	20	PnCW	PnCW	NNP
cord-265941-eff4le0g	313	21	)	)	-RRB-
cord-265941-eff4le0g	313	22	of	of	IN
cord-265941-eff4le0g	313	23	S.	S.	NNP
cord-265941-eff4le0g	313	24	pneumoniae	pneumoniae	NN
cord-265941-eff4le0g	313	25	.	.	.
cord-265941-eff4le0g	314	1	PnCW	PnCW	NNP
cord-265941-eff4le0g	314	2	induces	induce	VBZ
cord-265941-eff4le0g	314	3	intensive	intensive	JJ
cord-265941-eff4le0g	314	4	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	314	5	responses	response	NNS
cord-265941-eff4le0g	314	6	by	by	IN
cord-265941-eff4le0g	314	7	macrophages	macrophage	NNS
cord-265941-eff4le0g	314	8	and	and	CC
cord-265941-eff4le0g	314	9	dendritic	dendritic	JJ
cord-265941-eff4le0g	314	10	cells	cell	NNS
cord-265941-eff4le0g	314	11	during	during	IN
cord-265941-eff4le0g	314	12	systemic	systemic	JJ
cord-265941-eff4le0g	314	13	infection	infection	NN
cord-265941-eff4le0g	314	14	in	in	IN
cord-265941-eff4le0g	314	15	a	a	DT
cord-265941-eff4le0g	314	16	TLR2-dependent	tlr2-dependent	NN
cord-265941-eff4le0g	314	17	,	,	,
cord-265941-eff4le0g	314	18	NOD2	NOD2	NNP
cord-265941-eff4le0g	314	19	/	/	SYM
cord-265941-eff4le0g	314	20	RIPK2-independent	RIPK2-independent	NNP
cord-265941-eff4le0g	314	21	manner	manner	NN
cord-265941-eff4le0g	314	22	[	[	-LRB-
cord-265941-eff4le0g	314	23	157	157	CD
cord-265941-eff4le0g	314	24	,	,	,
cord-265941-eff4le0g	314	25	158	158	CD
cord-265941-eff4le0g	314	26	]	]	-RRB-
cord-265941-eff4le0g	314	27	.	.	.
cord-265941-eff4le0g	315	1	This	this	DT
cord-265941-eff4le0g	315	2	inflammation	inflammation	NN
cord-265941-eff4le0g	315	3	is	be	VBZ
cord-265941-eff4le0g	315	4	critically	critically	RB
cord-265941-eff4le0g	315	5	modulated	modulate	VBN
cord-265941-eff4le0g	315	6	by	by	IN
cord-265941-eff4le0g	315	7	IL-10	IL-10	NNP
cord-265941-eff4le0g	315	8	[	[	-LRB-
cord-265941-eff4le0g	315	9	159	159	CD
cord-265941-eff4le0g	315	10	]	]	-RRB-
cord-265941-eff4le0g	315	11	,	,	,
cord-265941-eff4le0g	315	12	as	as	IN
cord-265941-eff4le0g	315	13	IL-10	IL-10	NNP
cord-265941-eff4le0g	315	14	deficiency	deficiency	NN
cord-265941-eff4le0g	315	15	increases	increase	VBZ
cord-265941-eff4le0g	315	16	mortality	mortality	NN
cord-265941-eff4le0g	315	17	in	in	IN
cord-265941-eff4le0g	315	18	S.	S.	NNP
cord-265941-eff4le0g	315	19	pneumoniae	pneumoniae	NN
cord-265941-eff4le0g	315	20	infection	infection	NN
cord-265941-eff4le0g	315	21	in	in	IN
cord-265941-eff4le0g	315	22	vivo	vivo	NN
cord-265941-eff4le0g	315	23	[	[	-LRB-
cord-265941-eff4le0g	315	24	160	160	CD
cord-265941-eff4le0g	315	25	]	]	-RRB-
cord-265941-eff4le0g	315	26	.	.	.
cord-265941-eff4le0g	316	1	Curiously	curiously	RB
cord-265941-eff4le0g	316	2	,	,	,
cord-265941-eff4le0g	316	3	this	this	DT
cord-265941-eff4le0g	316	4	IL-10	IL-10	NNP
cord-265941-eff4le0g	316	5	production	production	NN
cord-265941-eff4le0g	316	6	is	be	VBZ
cord-265941-eff4le0g	316	7	TLR2	TLR2	NNP
cord-265941-eff4le0g	316	8	,	,	,
cord-265941-eff4le0g	316	9	NOD2	NOD2	NNPS
cord-265941-eff4le0g	316	10	and	and	CC
cord-265941-eff4le0g	316	11	RIPK2-dependent	RIPK2-dependent	NNP
cord-265941-eff4le0g	316	12	,	,	,
cord-265941-eff4le0g	316	13	whereby	whereby	WRB
cord-265941-eff4le0g	316	14	RIPK2	ripk2	XX
cord-265941-eff4le0g	316	15	or	or	CC
cord-265941-eff4le0g	316	16	NOD2-deficient	NOD2-deficient	NNP
cord-265941-eff4le0g	316	17	BMDMs	bmdm	NNS
cord-265941-eff4le0g	316	18	have	have	VBP
cord-265941-eff4le0g	316	19	compromised	compromise	VBN
cord-265941-eff4le0g	316	20	IL-10	IL-10	NNP
cord-265941-eff4le0g	316	21	production	production	NN
cord-265941-eff4le0g	316	22	in	in	IN
cord-265941-eff4le0g	316	23	response	response	NN
cord-265941-eff4le0g	316	24	to	to	IN
cord-265941-eff4le0g	316	25	PnCW	PnCW	NNP
cord-265941-eff4le0g	316	26	[	[	-LRB-
cord-265941-eff4le0g	316	27	157	157	CD
cord-265941-eff4le0g	316	28	]	]	-RRB-
cord-265941-eff4le0g	316	29	.	.	.
cord-265941-eff4le0g	317	1	Although	although	IN
cord-265941-eff4le0g	317	2	the	the	DT
cord-265941-eff4le0g	317	3	mechanism	mechanism	NN
cord-265941-eff4le0g	317	4	is	be	VBZ
cord-265941-eff4le0g	317	5	not	not	RB
cord-265941-eff4le0g	317	6	clear	clear	JJ
cord-265941-eff4le0g	317	7	,	,	,
cord-265941-eff4le0g	317	8	this	this	DT
cord-265941-eff4le0g	317	9	suggests	suggest	VBZ
cord-265941-eff4le0g	317	10	that	that	IN
cord-265941-eff4le0g	317	11	there	there	EX
cord-265941-eff4le0g	317	12	is	be	VBZ
cord-265941-eff4le0g	317	13	cell	cell	NN
cord-265941-eff4le0g	317	14	-	-	HYPH
cord-265941-eff4le0g	317	15	specific	specific	JJ
cord-265941-eff4le0g	317	16	and	and	CC
cord-265941-eff4le0g	317	17	stimulus	stimulus	NN
cord-265941-eff4le0g	317	18	-	-	HYPH
cord-265941-eff4le0g	317	19	specific	specific	JJ
cord-265941-eff4le0g	317	20	crosstalk	crosstalk	NN
cord-265941-eff4le0g	317	21	between	between	IN
cord-265941-eff4le0g	317	22	TLR2	TLR2	NNP
cord-265941-eff4le0g	317	23	and	and	CC
cord-265941-eff4le0g	317	24	NOD2	NOD2	NNPS
cord-265941-eff4le0g	317	25	/	/	SYM
cord-265941-eff4le0g	317	26	RIPK2	RIPK2	HYPH
cord-265941-eff4le0g	317	27	pathways	pathway	NNS
cord-265941-eff4le0g	317	28	[	[	-LRB-
cord-265941-eff4le0g	317	29	161	161	CD
cord-265941-eff4le0g	317	30	]	]	-RRB-
cord-265941-eff4le0g	317	31	.	.	.
cord-265941-eff4le0g	318	1	During	during	IN
cord-265941-eff4le0g	318	2	L.	L.	NNP
cord-265941-eff4le0g	318	3	pneumophila	pneumophila	NN
cord-265941-eff4le0g	318	4	infection	infection	NN
cord-265941-eff4le0g	318	5	,	,	,
cord-265941-eff4le0g	318	6	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	318	7	mediates	mediate	VBZ
cord-265941-eff4le0g	318	8	NF	nf	NN
cord-265941-eff4le0g	318	9	-	-	HYPH
cord-265941-eff4le0g	318	10	κB	κb	CD
cord-265941-eff4le0g	318	11	activation	activation	NN
cord-265941-eff4le0g	318	12	independently	independently	RB
cord-265941-eff4le0g	318	13	of	of	IN
cord-265941-eff4le0g	318	14	TLR	TLR	NNP
cord-265941-eff4le0g	318	15	/	/	SYM
cord-265941-eff4le0g	318	16	MyD88	MyD88	NNP
cord-265941-eff4le0g	318	17	activation	activation	NN
cord-265941-eff4le0g	318	18	,	,	,
cord-265941-eff4le0g	318	19	but	but	CC
cord-265941-eff4le0g	318	20	in	in	IN
cord-265941-eff4le0g	318	21	response	response	NN
cord-265941-eff4le0g	318	22	to	to	IN
cord-265941-eff4le0g	318	23	bacterial	bacterial	JJ
cord-265941-eff4le0g	318	24	factors	factor	NNS
cord-265941-eff4le0g	318	25	(	(	-LRB-
cord-265941-eff4le0g	318	26	likely	likely	RB
cord-265941-eff4le0g	318	27	PGN	PGN	NNP
cord-265941-eff4le0g	318	28	)	)	-RRB-
cord-265941-eff4le0g	318	29	delivered	deliver	VBN
cord-265941-eff4le0g	318	30	directly	directly	RB
cord-265941-eff4le0g	318	31	into	into	IN
cord-265941-eff4le0g	318	32	the	the	DT
cord-265941-eff4le0g	318	33	host	host	NN
cord-265941-eff4le0g	318	34	cell	cell	NN
cord-265941-eff4le0g	318	35	cytosol	cytosol	NN
cord-265941-eff4le0g	318	36	by	by	IN
cord-265941-eff4le0g	318	37	the	the	DT
cord-265941-eff4le0g	318	38	Legionella	Legionella	NNP
cord-265941-eff4le0g	318	39	T4SS	T4SS	NNP
cord-265941-eff4le0g	318	40	[	[	-LRB-
cord-265941-eff4le0g	318	41	145	145	CD
cord-265941-eff4le0g	318	42	]	]	-RRB-
cord-265941-eff4le0g	318	43	.	.	.
cord-265941-eff4le0g	319	1	in	in	IN
cord-265941-eff4le0g	319	2	vivo	vivo	NNP
cord-265941-eff4le0g	319	3	studies	study	NNS
cord-265941-eff4le0g	319	4	have	have	VBP
cord-265941-eff4le0g	319	5	shown	show	VBN
cord-265941-eff4le0g	319	6	that	that	IN
cord-265941-eff4le0g	319	7	RIPK2-deficiency	RIPK2-deficiency	NNP
cord-265941-eff4le0g	319	8	results	result	NNS
cord-265941-eff4le0g	319	9	in	in	IN
cord-265941-eff4le0g	319	10	poor	poor	JJ
cord-265941-eff4le0g	319	11	neutrophil	neutrophil	NN
cord-265941-eff4le0g	319	12	recruitment	recruitment	NN
cord-265941-eff4le0g	319	13	into	into	IN
cord-265941-eff4le0g	319	14	the	the	DT
cord-265941-eff4le0g	319	15	lung	lung	NN
cord-265941-eff4le0g	319	16	,	,	,
cord-265941-eff4le0g	319	17	a	a	DT
cord-265941-eff4le0g	319	18	significant	significant	JJ
cord-265941-eff4le0g	319	19	reduction	reduction	NN
cord-265941-eff4le0g	319	20	in	in	IN
cord-265941-eff4le0g	319	21	proinflammatory	proinflammatory	JJ
cord-265941-eff4le0g	319	22	cytokine	cytokine	NN
cord-265941-eff4le0g	319	23	and	and	CC
cord-265941-eff4le0g	319	24	chemokine	chemokine	NN
cord-265941-eff4le0g	319	25	secretion	secretion	NN
cord-265941-eff4le0g	319	26	,	,	,
cord-265941-eff4le0g	319	27	and	and	CC
cord-265941-eff4le0g	319	28	increased	increase	VBN
cord-265941-eff4le0g	319	29	bacterial	bacterial	JJ
cord-265941-eff4le0g	319	30	burden	burden	NN
cord-265941-eff4le0g	319	31	[	[	-LRB-
cord-265941-eff4le0g	319	32	162	162	CD
cord-265941-eff4le0g	319	33	]	]	-RRB-
cord-265941-eff4le0g	319	34	.	.	.
cord-265941-eff4le0g	320	1	While	while	IN
cord-265941-eff4le0g	320	2	one	one	CD
cord-265941-eff4le0g	320	3	study	study	NN
cord-265941-eff4le0g	320	4	suggested	suggest	VBD
cord-265941-eff4le0g	320	5	only	only	RB
cord-265941-eff4le0g	320	6	NOD1	NOD1	NNP
cord-265941-eff4le0g	320	7	was	be	VBD
cord-265941-eff4le0g	320	8	involved	involve	VBN
cord-265941-eff4le0g	320	9	in	in	IN
cord-265941-eff4le0g	320	10	these	these	DT
cord-265941-eff4le0g	320	11	responses	response	NNS
cord-265941-eff4le0g	320	12	in	in	IN
cord-265941-eff4le0g	320	13	Ripk2	Ripk2	NNP
cord-265941-eff4le0g	320	14	−	−	NNP
cord-265941-eff4le0g	320	15	/−	/−	.
cord-265941-eff4le0g	320	16	mice	mouse	NNS
cord-265941-eff4le0g	320	17	[	[	-LRB-
cord-265941-eff4le0g	320	18	163	163	CD
cord-265941-eff4le0g	320	19	]	]	-RRB-
cord-265941-eff4le0g	320	20	,	,	,
cord-265941-eff4le0g	320	21	another	another	DT
cord-265941-eff4le0g	320	22	implicated	implicate	VBD
cord-265941-eff4le0g	320	23	both	both	CC
cord-265941-eff4le0g	320	24	NOD1	NOD1	NNP
cord-265941-eff4le0g	320	25	and	and	CC
cord-265941-eff4le0g	320	26	NOD2	NOD2	NNPS
cord-265941-eff4le0g	320	27	[	[	-LRB-
cord-265941-eff4le0g	320	28	162	162	CD
cord-265941-eff4le0g	320	29	]	]	-RRB-
cord-265941-eff4le0g	320	30	.	.	.
cord-265941-eff4le0g	321	1	Overall	overall	RB
cord-265941-eff4le0g	321	2	,	,	,
cord-265941-eff4le0g	321	3	it	-PRON-	PRP
cord-265941-eff4le0g	321	4	appears	appear	VBZ
cord-265941-eff4le0g	321	5	NOD	NOD	NNP
cord-265941-eff4le0g	321	6	signaling	signaling	NN
cord-265941-eff4le0g	321	7	plays	play	VBZ
cord-265941-eff4le0g	321	8	a	a	DT
cord-265941-eff4le0g	321	9	role	role	NN
cord-265941-eff4le0g	321	10	in	in	IN
cord-265941-eff4le0g	321	11	RIPK2-mediated	ripk2-mediate	VBN
cord-265941-eff4le0g	321	12	responses	response	NNS
cord-265941-eff4le0g	321	13	to	to	IN
cord-265941-eff4le0g	321	14	L.	L.	NNP
cord-265941-eff4le0g	321	15	pneumophila	pneumophila	NN
cord-265941-eff4le0g	321	16	,	,	,
cord-265941-eff4le0g	321	17	however	however	RB
cord-265941-eff4le0g	321	18	it	-PRON-	PRP
cord-265941-eff4le0g	321	19	does	do	VBZ
cord-265941-eff4le0g	321	20	n't	not	RB
cord-265941-eff4le0g	321	21	rule	rule	VB
cord-265941-eff4le0g	321	22	out	out	RP
cord-265941-eff4le0g	321	23	involvement	involvement	NN
cord-265941-eff4le0g	321	24	of	of	IN
cord-265941-eff4le0g	321	25	other	other	JJ
cord-265941-eff4le0g	321	26	signaling	signal	VBG
cord-265941-eff4le0g	321	27	pathways	pathway	NNS
cord-265941-eff4le0g	321	28	initiated	initiate	VBN
cord-265941-eff4le0g	321	29	by	by	IN
cord-265941-eff4le0g	321	30	TLR2	TLR2	NNP
cord-265941-eff4le0g	321	31	,	,	,
cord-265941-eff4le0g	321	32	IL-1R	IL-1R	NNP
cord-265941-eff4le0g	321	33	or	or	CC
cord-265941-eff4le0g	321	34	IL-18R	IL-18R	NNP
cord-265941-eff4le0g	321	35	[	[	-LRB-
cord-265941-eff4le0g	321	36	137	137	CD
cord-265941-eff4le0g	321	37	]	]	-RRB-
cord-265941-eff4le0g	321	38	.	.	.
cord-265941-eff4le0g	322	1	Borrelia	Borrelia	NNP
cord-265941-eff4le0g	322	2	burgdorferi	burgdorferi	NN
cord-265941-eff4le0g	322	3	is	be	VBZ
cord-265941-eff4le0g	322	4	the	the	DT
cord-265941-eff4le0g	322	5	causative	causative	JJ
cord-265941-eff4le0g	322	6	agent	agent	NN
cord-265941-eff4le0g	322	7	of	of	IN
cord-265941-eff4le0g	322	8	Lyme	Lyme	NNP
cord-265941-eff4le0g	322	9	disease	disease	NN
cord-265941-eff4le0g	322	10	,	,	,
cord-265941-eff4le0g	322	11	a	a	DT
cord-265941-eff4le0g	322	12	tickborne	tickborne	JJ
cord-265941-eff4le0g	322	13	infection	infection	NN
cord-265941-eff4le0g	322	14	that	that	WDT
cord-265941-eff4le0g	322	15	causes	cause	VBZ
cord-265941-eff4le0g	322	16	multi	multi	JJ
cord-265941-eff4le0g	322	17	-	-	JJ
cord-265941-eff4le0g	322	18	systemic	systemic	JJ
cord-265941-eff4le0g	322	19	illness	illness	NN
cord-265941-eff4le0g	322	20	[	[	-LRB-
cord-265941-eff4le0g	322	21	164	164	CD
cord-265941-eff4le0g	322	22	]	]	-RRB-
cord-265941-eff4le0g	322	23	.	.	.
cord-265941-eff4le0g	323	1	Early	early	JJ
cord-265941-eff4le0g	323	2	studies	study	NNS
cord-265941-eff4le0g	323	3	showed	show	VBD
cord-265941-eff4le0g	323	4	that	that	IN
cord-265941-eff4le0g	323	5	RIPK2	ripk2	DT
cord-265941-eff4le0g	323	6	expression	expression	NN
cord-265941-eff4le0g	323	7	is	be	VBZ
cord-265941-eff4le0g	323	8	increased	increase	VBN
cord-265941-eff4le0g	323	9	in	in	IN
cord-265941-eff4le0g	323	10	astrocytes	astrocyte	NNS
cord-265941-eff4le0g	323	11	and	and	CC
cord-265941-eff4le0g	323	12	microglia	microglia	NN
cord-265941-eff4le0g	323	13	exposed	expose	VBN
cord-265941-eff4le0g	323	14	to	to	IN
cord-265941-eff4le0g	323	15	Borrelia	Borrelia	NNP
cord-265941-eff4le0g	323	16	spirochetes	spirochete	NNS
cord-265941-eff4le0g	323	17	[	[	-LRB-
cord-265941-eff4le0g	323	18	165	165	CD
cord-265941-eff4le0g	323	19	,	,	,
cord-265941-eff4le0g	323	20	166	166	CD
cord-265941-eff4le0g	323	21	]	]	-RRB-
cord-265941-eff4le0g	323	22	.	.	.
cord-265941-eff4le0g	324	1	Subsequent	subsequent	JJ
cord-265941-eff4le0g	324	2	work	work	NN
cord-265941-eff4le0g	324	3	showed	show	VBD
cord-265941-eff4le0g	324	4	that	that	IN
cord-265941-eff4le0g	324	5	peritoneal	peritoneal	JJ
cord-265941-eff4le0g	324	6	macrophages	macrophage	NNS
cord-265941-eff4le0g	324	7	from	from	IN
cord-265941-eff4le0g	324	8	Ripk2	Ripk2	NNP
cord-265941-eff4le0g	324	9	−	−	NNP
cord-265941-eff4le0g	325	1	/−	/−	.
cord-265941-eff4le0g	326	1	mice	mouse	NNS
cord-265941-eff4le0g	326	2	exhibit	exhibit	VBP
cord-265941-eff4le0g	326	3	a	a	DT
cord-265941-eff4le0g	326	4	significant	significant	JJ
cord-265941-eff4le0g	326	5	reduction	reduction	NN
cord-265941-eff4le0g	326	6	in	in	IN
cord-265941-eff4le0g	326	7	IL-1β	il-1β	NN
cord-265941-eff4le0g	326	8	,	,	.
cord-265941-eff4le0g	327	1	IL-6	IL-6	NNP
cord-265941-eff4le0g	327	2	and	and	CC
cord-265941-eff4le0g	327	3	IL-8	IL-8	NNP
cord-265941-eff4le0g	327	4	production	production	NN
cord-265941-eff4le0g	327	5	following	follow	VBG
cord-265941-eff4le0g	327	6	stimulation	stimulation	NN
cord-265941-eff4le0g	327	7	with	with	IN
cord-265941-eff4le0g	327	8	heat	heat	NN
cord-265941-eff4le0g	327	9	-	-	HYPH
cord-265941-eff4le0g	327	10	killed	kill	VBN
cord-265941-eff4le0g	327	11	Borrelia	Borrelia	NNP
cord-265941-eff4le0g	327	12	,	,	,
cord-265941-eff4le0g	327	13	compared	compare	VBN
cord-265941-eff4le0g	327	14	to	to	IN
cord-265941-eff4le0g	327	15	WT	wt	NN
cord-265941-eff4le0g	327	16	mice	mouse	NNS
cord-265941-eff4le0g	327	17	[	[	-LRB-
cord-265941-eff4le0g	327	18	167	167	CD
cord-265941-eff4le0g	327	19	]	]	-RRB-
cord-265941-eff4le0g	327	20	.	.	.
cord-265941-eff4le0g	328	1	Here	here	RB
cord-265941-eff4le0g	328	2	,	,	,
cord-265941-eff4le0g	328	3	through	through	IN
cord-265941-eff4le0g	328	4	an	an	DT
cord-265941-eff4le0g	328	5	unknown	unknown	JJ
cord-265941-eff4le0g	328	6	mechanism	mechanism	NN
cord-265941-eff4le0g	328	7	,	,	,
cord-265941-eff4le0g	328	8	uptake	uptake	NN
cord-265941-eff4le0g	328	9	and	and	CC
cord-265941-eff4le0g	328	10	degradation	degradation	NN
cord-265941-eff4le0g	328	11	of	of	IN
cord-265941-eff4le0g	328	12	Borrelia	Borrelia	NNP
cord-265941-eff4le0g	328	13	in	in	IN
cord-265941-eff4le0g	328	14	lysosomes	lysosome	NNS
cord-265941-eff4le0g	328	15	introduces	introduce	VBZ
cord-265941-eff4le0g	328	16	PGN	PGN	NNP
cord-265941-eff4le0g	328	17	to	to	IN
cord-265941-eff4le0g	328	18	the	the	DT
cord-265941-eff4le0g	328	19	cytosol	cytosol	NN
cord-265941-eff4le0g	328	20	and	and	CC
cord-265941-eff4le0g	328	21	stimulates	stimulate	VBZ
cord-265941-eff4le0g	328	22	NOD2	NOD2	NNP
cord-265941-eff4le0g	328	23	/	/	SYM
cord-265941-eff4le0g	328	24	RIPK2-mediated	ripk2-mediate	VBN
cord-265941-eff4le0g	328	25	NF	NF	NNP
cord-265941-eff4le0g	328	26	-	-	HYPH
cord-265941-eff4le0g	328	27	κB	κb	CD
cord-265941-eff4le0g	328	28	activation	activation	NN
cord-265941-eff4le0g	328	29	and	and	CC
cord-265941-eff4le0g	328	30	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	328	31	cytokine	cytokine	NN
cord-265941-eff4le0g	328	32	production	production	NN
cord-265941-eff4le0g	328	33	[	[	-LRB-
cord-265941-eff4le0g	328	34	167	167	CD
cord-265941-eff4le0g	328	35	]	]	-RRB-
cord-265941-eff4le0g	328	36	.	.	.
cord-265941-eff4le0g	329	1	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	329	2	induces	induce	VBZ
cord-265941-eff4le0g	329	3	antibacterial	antibacterial	JJ
cord-265941-eff4le0g	329	4	autophagic	autophagic	NN
cord-265941-eff4le0g	329	5	responses	response	NNS
cord-265941-eff4le0g	329	6	by	by	IN
cord-265941-eff4le0g	329	7	signaling	signal	VBG
cord-265941-eff4le0g	329	8	between	between	IN
cord-265941-eff4le0g	329	9	NODs	nod	NNS
cord-265941-eff4le0g	329	10	and	and	CC
cord-265941-eff4le0g	329	11	the	the	DT
cord-265941-eff4le0g	329	12	autophagy	autophagy	NN
cord-265941-eff4le0g	329	13	factor	factor	NN
cord-265941-eff4le0g	330	1	ATG16L1	ATG16L1	NNP
cord-265941-eff4le0g	330	2	[	[	-LRB-
cord-265941-eff4le0g	330	3	148	148	CD
cord-265941-eff4le0g	330	4	]	]	-RRB-
cord-265941-eff4le0g	331	1	(	(	-LRB-
cord-265941-eff4le0g	331	2	Fig	Fig	NNP
cord-265941-eff4le0g	331	3	.	.	.
cord-265941-eff4le0g	331	4	3	3	CD
cord-265941-eff4le0g	331	5	)	)	-RRB-
cord-265941-eff4le0g	331	6	.	.	.
cord-265941-eff4le0g	332	1	Mutations	mutation	NNS
cord-265941-eff4le0g	332	2	in	in	IN
cord-265941-eff4le0g	332	3	ATG16L1	ATG16L1	NNS
cord-265941-eff4le0g	332	4	disrupt	disrupt	VBP
cord-265941-eff4le0g	332	5	an	an	DT
cord-265941-eff4le0g	332	6	inhibitory	inhibitory	JJ
cord-265941-eff4le0g	332	7	interaction	interaction	NN
cord-265941-eff4le0g	332	8	with	with	IN
cord-265941-eff4le0g	332	9	NOD2	NOD2	NNPS
cord-265941-eff4le0g	332	10	and	and	CC
cord-265941-eff4le0g	332	11	consequently	consequently	RB
cord-265941-eff4le0g	332	12	increase	increase	VB
cord-265941-eff4le0g	332	13	the	the	DT
cord-265941-eff4le0g	332	14	activation	activation	NN
cord-265941-eff4le0g	332	15	of	of	IN
cord-265941-eff4le0g	332	16	RIPK2	ripk2	DT
cord-265941-eff4le0g	332	17	[	[	-LRB-
cord-265941-eff4le0g	332	18	150	150	CD
cord-265941-eff4le0g	332	19	]	]	-RRB-
cord-265941-eff4le0g	332	20	.	.	.
cord-265941-eff4le0g	333	1	Excessive	excessive	JJ
cord-265941-eff4le0g	333	2	RIPK2	ripk2	DT
cord-265941-eff4le0g	333	3	activation	activation	NN
cord-265941-eff4le0g	333	4	has	have	VBZ
cord-265941-eff4le0g	333	5	been	be	VBN
cord-265941-eff4le0g	333	6	reported	report	VBN
cord-265941-eff4le0g	333	7	in	in	IN
cord-265941-eff4le0g	333	8	pediatric	pediatric	JJ
cord-265941-eff4le0g	333	9	Crohn	Crohn	NNP
cord-265941-eff4le0g	333	10	's	's	POS
cord-265941-eff4le0g	333	11	disease	disease	NN
cord-265941-eff4le0g	333	12	(	(	-LRB-
cord-265941-eff4le0g	333	13	CD	CD	NNP
cord-265941-eff4le0g	333	14	)	)	-RRB-
cord-265941-eff4le0g	333	15	[	[	-LRB-
cord-265941-eff4le0g	333	16	168	168	CD
cord-265941-eff4le0g	333	17	,	,	,
cord-265941-eff4le0g	333	18	169	169	CD
cord-265941-eff4le0g	333	19	]	]	-RRB-
cord-265941-eff4le0g	333	20	and	and	CC
cord-265941-eff4le0g	333	21	there	there	EX
cord-265941-eff4le0g	333	22	is	be	VBZ
cord-265941-eff4le0g	333	23	a	a	DT
cord-265941-eff4le0g	333	24	strong	strong	JJ
cord-265941-eff4le0g	333	25	link	link	NN
cord-265941-eff4le0g	333	26	between	between	IN
cord-265941-eff4le0g	333	27	resident	resident	JJ
cord-265941-eff4le0g	333	28	intestinal	intestinal	JJ
cord-265941-eff4le0g	333	29	bacteria	bacteria	NNS
cord-265941-eff4le0g	333	30	and	and	CC
cord-265941-eff4le0g	333	31	CD	cd	NN
cord-265941-eff4le0g	333	32	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	333	33	;	;	:
cord-265941-eff4le0g	333	34	therefore	therefore	RB
cord-265941-eff4le0g	333	35	,	,	,
cord-265941-eff4le0g	333	36	it	-PRON-	PRP
cord-265941-eff4le0g	333	37	has	have	VBZ
cord-265941-eff4le0g	333	38	been	be	VBN
cord-265941-eff4le0g	333	39	proposed	propose	VBN
cord-265941-eff4le0g	333	40	that	that	IN
cord-265941-eff4le0g	333	41	ineffective	ineffective	JJ
cord-265941-eff4le0g	333	42	bacterial	bacterial	JJ
cord-265941-eff4le0g	333	43	clearance	clearance	NN
cord-265941-eff4le0g	333	44	due	due	JJ
cord-265941-eff4le0g	333	45	to	to	IN
cord-265941-eff4le0g	333	46	impaired	impaired	JJ
cord-265941-eff4le0g	333	47	anti	anti	JJ
cord-265941-eff4le0g	333	48	-	-	JJ
cord-265941-eff4le0g	333	49	bacterial	bacterial	JJ
cord-265941-eff4le0g	333	50	autophagy	autophagy	NN
cord-265941-eff4le0g	333	51	is	be	VBZ
cord-265941-eff4le0g	333	52	an	an	DT
cord-265941-eff4le0g	333	53	important	important	JJ
cord-265941-eff4le0g	333	54	contributor	contributor	NN
cord-265941-eff4le0g	333	55	to	to	IN
cord-265941-eff4le0g	333	56	the	the	DT
cord-265941-eff4le0g	333	57	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	333	58	of	of	IN
cord-265941-eff4le0g	333	59	this	this	DT
cord-265941-eff4le0g	333	60	chronic	chronic	JJ
cord-265941-eff4le0g	333	61	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	333	62	disease	disease	NN
cord-265941-eff4le0g	333	63	[	[	-LRB-
cord-265941-eff4le0g	333	64	170	170	CD
cord-265941-eff4le0g	333	65	,	,	,
cord-265941-eff4le0g	333	66	171	171	CD
cord-265941-eff4le0g	333	67	]	]	-RRB-
cord-265941-eff4le0g	333	68	.	.	.
cord-265941-eff4le0g	334	1	Autophagy	Autophagy	NNP
cord-265941-eff4le0g	334	2	has	have	VBZ
cord-265941-eff4le0g	334	3	an	an	DT
cord-265941-eff4le0g	334	4	essential	essential	JJ
cord-265941-eff4le0g	334	5	role	role	NN
cord-265941-eff4le0g	334	6	in	in	IN
cord-265941-eff4le0g	334	7	innate	innate	JJ
cord-265941-eff4le0g	334	8	immunity	immunity	NN
cord-265941-eff4le0g	334	9	and	and	CC
cord-265941-eff4le0g	334	10	the	the	DT
cord-265941-eff4le0g	334	11	elimination	elimination	NN
cord-265941-eff4le0g	334	12	of	of	IN
cord-265941-eff4le0g	334	13	pathogens	pathogen	NNS
cord-265941-eff4le0g	334	14	that	that	WDT
cord-265941-eff4le0g	334	15	have	have	VBP
cord-265941-eff4le0g	334	16	escaped	escape	VBN
cord-265941-eff4le0g	334	17	into	into	IN
cord-265941-eff4le0g	334	18	the	the	DT
cord-265941-eff4le0g	334	19	cytoplasm	cytoplasm	NN
cord-265941-eff4le0g	334	20	,	,	,
cord-265941-eff4le0g	334	21	as	as	IN
cord-265941-eff4le0g	334	22	it	-PRON-	PRP
cord-265941-eff4le0g	334	23	forms	form	VBZ
cord-265941-eff4le0g	334	24	a	a	DT
cord-265941-eff4le0g	334	25	double	double	RB
cord-265941-eff4le0g	334	26	-	-	HYPH
cord-265941-eff4le0g	334	27	layered	layered	JJ
cord-265941-eff4le0g	334	28	membrane	membrane	NN
cord-265941-eff4le0g	334	29	that	that	WDT
cord-265941-eff4le0g	334	30	envelopes	envelop	VBZ
cord-265941-eff4le0g	334	31	cytosolic	cytosolic	JJ
cord-265941-eff4le0g	334	32	bacteria	bacteria	NNS
cord-265941-eff4le0g	334	33	for	for	IN
cord-265941-eff4le0g	334	34	degradation	degradation	NN
cord-265941-eff4le0g	334	35	via	via	IN
cord-265941-eff4le0g	334	36	fusion	fusion	NN
cord-265941-eff4le0g	334	37	with	with	IN
cord-265941-eff4le0g	334	38	lysosomes	lysosome	NNS
cord-265941-eff4le0g	334	39	[	[	-LRB-
cord-265941-eff4le0g	334	40	172	172	CD
cord-265941-eff4le0g	334	41	]	]	-RRB-
cord-265941-eff4le0g	334	42	[	[	-LRB-
cord-265941-eff4le0g	334	43	173	173	CD
cord-265941-eff4le0g	334	44	]	]	-RRB-
cord-265941-eff4le0g	334	45	[	[	-LRB-
cord-265941-eff4le0g	334	46	174	174	CD
cord-265941-eff4le0g	334	47	]	]	-RRB-
cord-265941-eff4le0g	334	48	.	.	.
cord-265941-eff4le0g	335	1	The	the	DT
cord-265941-eff4le0g	335	2	invasive	invasive	JJ
cord-265941-eff4le0g	335	3	gastrointestinal	gastrointestinal	JJ
cord-265941-eff4le0g	335	4	pathogen	pathogen	NN
cord-265941-eff4le0g	335	5	,	,	,
cord-265941-eff4le0g	335	6	Shigella	Shigella	NNP
cord-265941-eff4le0g	335	7	flexneri	flexneri	NN
cord-265941-eff4le0g	335	8	,	,	,
cord-265941-eff4le0g	335	9	is	be	VBZ
cord-265941-eff4le0g	335	10	a	a	DT
cord-265941-eff4le0g	335	11	major	major	JJ
cord-265941-eff4le0g	335	12	cause	cause	NN
cord-265941-eff4le0g	335	13	of	of	IN
cord-265941-eff4le0g	335	14	morbidity	morbidity	NN
cord-265941-eff4le0g	335	15	and	and	CC
cord-265941-eff4le0g	335	16	mortality	mortality	NN
cord-265941-eff4le0g	335	17	in	in	IN
cord-265941-eff4le0g	335	18	children	child	NNS
cord-265941-eff4le0g	335	19	under	under	IN
cord-265941-eff4le0g	335	20	5	5	CD
cord-265941-eff4le0g	335	21	years	year	NNS
cord-265941-eff4le0g	335	22	in	in	IN
cord-265941-eff4le0g	335	23	developing	develop	VBG
cord-265941-eff4le0g	335	24	countries	country	NNS
cord-265941-eff4le0g	335	25	[	[	-LRB-
cord-265941-eff4le0g	335	26	175	175	CD
cord-265941-eff4le0g	335	27	]	]	-RRB-
cord-265941-eff4le0g	335	28	,	,	,
cord-265941-eff4le0g	335	29	and	and	CC
cord-265941-eff4le0g	335	30	is	be	VBZ
cord-265941-eff4le0g	335	31	an	an	DT
cord-265941-eff4le0g	335	32	emerging	emerge	VBG
cord-265941-eff4le0g	335	33	sexually	sexually	RB
cord-265941-eff4le0g	335	34	transmitted	transmit	VBN
cord-265941-eff4le0g	335	35	infection	infection	NN
cord-265941-eff4le0g	335	36	of	of	IN
cord-265941-eff4le0g	335	37	men	man	NNS
cord-265941-eff4le0g	335	38	who	who	WP
cord-265941-eff4le0g	335	39	have	have	VBP
cord-265941-eff4le0g	335	40	sex	sex	NN
cord-265941-eff4le0g	335	41	with	with	IN
cord-265941-eff4le0g	335	42	men	man	NNS
cord-265941-eff4le0g	335	43	[	[	-LRB-
cord-265941-eff4le0g	335	44	176	176	CD
cord-265941-eff4le0g	335	45	]	]	-RRB-
cord-265941-eff4le0g	335	46	.	.	.
cord-265941-eff4le0g	336	1	S.	S.	NNP
cord-265941-eff4le0g	336	2	flexneri	flexneri	NN
cord-265941-eff4le0g	336	3	induces	induce	VBZ
cord-265941-eff4le0g	336	4	NF	NF	NNP
cord-265941-eff4le0g	336	5	-	-	HYPH
cord-265941-eff4le0g	336	6	κB	κB	NNP
cord-265941-eff4le0g	336	7	and	and	CC
cord-265941-eff4le0g	336	8	JNK	JNK	NNP
cord-265941-eff4le0g	336	9	activation	activation	NN
cord-265941-eff4le0g	336	10	in	in	IN
cord-265941-eff4le0g	336	11	a	a	DT
cord-265941-eff4le0g	336	12	NOD1	NOD1	NNP
cord-265941-eff4le0g	336	13	/	/	SYM
cord-265941-eff4le0g	336	14	RIPK2-dependent	ripk2-dependent	NN
cord-265941-eff4le0g	336	15	manner	manner	NN
cord-265941-eff4le0g	336	16	to	to	TO
cord-265941-eff4le0g	336	17	limit	limit	VB
cord-265941-eff4le0g	336	18	bacterial	bacterial	JJ
cord-265941-eff4le0g	336	19	replication	replication	NN
cord-265941-eff4le0g	336	20	in	in	IN
cord-265941-eff4le0g	336	21	intestinal	intestinal	JJ
cord-265941-eff4le0g	336	22	epithelial	epithelial	JJ
cord-265941-eff4le0g	336	23	cells	cell	NNS
cord-265941-eff4le0g	336	24	[	[	-LRB-
cord-265941-eff4le0g	336	25	177	177	CD
cord-265941-eff4le0g	336	26	]	]	-RRB-
cord-265941-eff4le0g	336	27	.	.	.
cord-265941-eff4le0g	337	1	Although	although	IN
cord-265941-eff4le0g	337	2	early	early	JJ
cord-265941-eff4le0g	337	3	studies	study	NNS
cord-265941-eff4le0g	337	4	did	do	VBD
cord-265941-eff4le0g	337	5	not	not	RB
cord-265941-eff4le0g	337	6	investigate	investigate	VB
cord-265941-eff4le0g	337	7	mechanisms	mechanism	NNS
cord-265941-eff4le0g	337	8	of	of	IN
cord-265941-eff4le0g	337	9	S.	S.	NNP
cord-265941-eff4le0g	337	10	flexneri	flexneri	NN
cord-265941-eff4le0g	337	11	killing	killing	NN
cord-265941-eff4le0g	337	12	,	,	,
cord-265941-eff4le0g	337	13	it	-PRON-	PRP
cord-265941-eff4le0g	337	14	was	be	VBD
cord-265941-eff4le0g	337	15	pivotal	pivotal	JJ
cord-265941-eff4le0g	337	16	in	in	IN
cord-265941-eff4le0g	337	17	understanding	understand	VBG
cord-265941-eff4le0g	337	18	the	the	DT
cord-265941-eff4le0g	337	19	mechanisms	mechanism	NNS
cord-265941-eff4le0g	337	20	of	of	IN
cord-265941-eff4le0g	337	21	NOD	nod	NN
cord-265941-eff4le0g	337	22	/	/	SYM
cord-265941-eff4le0g	337	23	RIPK2-mediated	ripk2-mediate	VBN
cord-265941-eff4le0g	337	24	autophagy	autophagy	NN
cord-265941-eff4le0g	337	25	in	in	IN
cord-265941-eff4le0g	337	26	future	future	JJ
cord-265941-eff4le0g	337	27	infection	infection	NN
cord-265941-eff4le0g	337	28	studies	study	NNS
cord-265941-eff4le0g	337	29	.	.	.
cord-265941-eff4le0g	338	1	The	the	DT
cord-265941-eff4le0g	338	2	gastric	gastric	JJ
cord-265941-eff4le0g	338	3	pathogen	pathogen	NN
cord-265941-eff4le0g	338	4	Helicobacter	helicobacter	NN
cord-265941-eff4le0g	338	5	pylori	pylori	NN
cord-265941-eff4le0g	338	6	is	be	VBZ
cord-265941-eff4le0g	338	7	subject	subject	JJ
cord-265941-eff4le0g	338	8	to	to	IN
cord-265941-eff4le0g	338	9	degradation	degradation	NN
cord-265941-eff4le0g	338	10	by	by	IN
cord-265941-eff4le0g	338	11	autophagy	autophagy	NN
cord-265941-eff4le0g	338	12	via	via	IN
cord-265941-eff4le0g	338	13	the	the	DT
cord-265941-eff4le0g	338	14	NOD1	NOD1	NNP
cord-265941-eff4le0g	339	1	/	/	NFP
cord-265941-eff4le0g	340	1	RIPK2	ripk2	DT
cord-265941-eff4le0g	340	2	signaling	signal	VBG
cord-265941-eff4le0g	340	3	axis	axis	NN
cord-265941-eff4le0g	340	4	.	.	.
cord-265941-eff4le0g	341	1	H.	H.	NNP
cord-265941-eff4le0g	341	2	pylori	pylori	NN
cord-265941-eff4le0g	341	3	infection	infection	NN
cord-265941-eff4le0g	341	4	has	have	VBZ
cord-265941-eff4le0g	341	5	long	long	RB
cord-265941-eff4le0g	341	6	been	be	VBN
cord-265941-eff4le0g	341	7	implicated	implicate	VBN
cord-265941-eff4le0g	341	8	in	in	IN
cord-265941-eff4le0g	341	9	the	the	DT
cord-265941-eff4le0g	341	10	development	development	NN
cord-265941-eff4le0g	341	11	of	of	IN
cord-265941-eff4le0g	341	12	gastric	gastric	JJ
cord-265941-eff4le0g	341	13	cancer	cancer	NN
cord-265941-eff4le0g	341	14	[	[	-LRB-
cord-265941-eff4le0g	341	15	178	178	CD
cord-265941-eff4le0g	341	16	]	]	-RRB-
cord-265941-eff4le0g	342	1	[	[	-LRB-
cord-265941-eff4le0g	342	2	179	179	CD
cord-265941-eff4le0g	342	3	]	]	-RRB-
cord-265941-eff4le0g	343	1	[	[	-LRB-
cord-265941-eff4le0g	343	2	180	180	CD
cord-265941-eff4le0g	343	3	]	]	-RRB-
cord-265941-eff4le0g	343	4	,	,	,
cord-265941-eff4le0g	343	5	and	and	CC
cord-265941-eff4le0g	343	6	recently	recently	RB
cord-265941-eff4le0g	343	7	,	,	,
cord-265941-eff4le0g	343	8	polymorphisms	polymorphism	NNS
cord-265941-eff4le0g	343	9	in	in	IN
cord-265941-eff4le0g	343	10	RIPK2	RIPK2	AFX
cord-265941-eff4le0g	343	11	were	be	VBD
cord-265941-eff4le0g	343	12	found	find	VBN
cord-265941-eff4le0g	343	13	to	to	TO
cord-265941-eff4le0g	343	14	be	be	VB
cord-265941-eff4le0g	343	15	associated	associate	VBN
cord-265941-eff4le0g	343	16	with	with	IN
cord-265941-eff4le0g	343	17	increased	increase	VBN
cord-265941-eff4le0g	343	18	susceptibility	susceptibility	NN
cord-265941-eff4le0g	343	19	to	to	IN
cord-265941-eff4le0g	343	20	gastric	gastric	JJ
cord-265941-eff4le0g	343	21	cancer	cancer	NN
cord-265941-eff4le0g	343	22	in	in	IN
cord-265941-eff4le0g	343	23	Japanese	japanese	JJ
cord-265941-eff4le0g	343	24	populations	population	NNS
cord-265941-eff4le0g	343	25	[	[	-LRB-
cord-265941-eff4le0g	343	26	181	181	CD
cord-265941-eff4le0g	343	27	]	]	-RRB-
cord-265941-eff4le0g	343	28	where	where	WRB
cord-265941-eff4le0g	343	29	the	the	DT
cord-265941-eff4le0g	343	30	prevalence	prevalence	NN
cord-265941-eff4le0g	343	31	of	of	IN
cord-265941-eff4le0g	343	32	this	this	DT
cord-265941-eff4le0g	343	33	disease	disease	NN
cord-265941-eff4le0g	343	34	is	be	VBZ
cord-265941-eff4le0g	343	35	very	very	RB
cord-265941-eff4le0g	343	36	high	high	JJ
cord-265941-eff4le0g	343	37	.	.	.
cord-265941-eff4le0g	344	1	Indeed	indeed	RB
cord-265941-eff4le0g	344	2	,	,	,
cord-265941-eff4le0g	344	3	Nod1	Nod1	NNP
cord-265941-eff4le0g	344	4	−	−	NNP
cord-265941-eff4le0g	345	1	/−	/−	.
cord-265941-eff4le0g	346	1	mice	mouse	NNS
cord-265941-eff4le0g	346	2	are	be	VBP
cord-265941-eff4le0g	346	3	highly	highly	RB
cord-265941-eff4le0g	346	4	susceptible	susceptible	JJ
cord-265941-eff4le0g	346	5	to	to	IN
cord-265941-eff4le0g	346	6	H.	h.	NN
cord-265941-eff4le0g	346	7	pylori	pylori	NN
cord-265941-eff4le0g	346	8	infection	infection	NN
cord-265941-eff4le0g	346	9	[	[	-LRB-
cord-265941-eff4le0g	346	10	182	182	CD
cord-265941-eff4le0g	346	11	]	]	-RRB-
cord-265941-eff4le0g	346	12	,	,	,
cord-265941-eff4le0g	346	13	and	and	CC
cord-265941-eff4le0g	346	14	mechanistically	mechanistically	RB
cord-265941-eff4le0g	346	15	,	,	,
cord-265941-eff4le0g	346	16	Irving	Irving	NNP
cord-265941-eff4le0g	346	17	et	et	NNP
cord-265941-eff4le0g	346	18	al	al	NNP
cord-265941-eff4le0g	346	19	.	.	.
cord-265941-eff4le0g	347	1	[	[	-LRB-
cord-265941-eff4le0g	347	2	149	149	CD
cord-265941-eff4le0g	347	3	]	]	-RRB-
cord-265941-eff4le0g	347	4	demonstrated	demonstrate	VBD
cord-265941-eff4le0g	347	5	that	that	IN
cord-265941-eff4le0g	347	6	in	in	IN
cord-265941-eff4le0g	347	7	gastric	gastric	JJ
cord-265941-eff4le0g	347	8	epithelial	epithelial	JJ
cord-265941-eff4le0g	347	9	cells	cell	NNS
cord-265941-eff4le0g	347	10	,	,	,
cord-265941-eff4le0g	347	11	RIPK2	ripk2	NN
cord-265941-eff4le0g	347	12	mediates	mediate	VBZ
cord-265941-eff4le0g	347	13	NOD1-dependent	NOD1-dependent	NNP
cord-265941-eff4le0g	348	1	IL-8	IL-8	NNP
cord-265941-eff4le0g	348	2	production	production	NN
cord-265941-eff4le0g	348	3	and	and	CC
cord-265941-eff4le0g	348	4	autophagosome	autophagosome	JJ
cord-265941-eff4le0g	348	5	formation	formation	NN
cord-265941-eff4le0g	348	6	in	in	IN
cord-265941-eff4le0g	348	7	early	early	JJ
cord-265941-eff4le0g	348	8	endosomes	endosome	NNS
cord-265941-eff4le0g	348	9	in	in	IN
cord-265941-eff4le0g	348	10	response	response	NN
cord-265941-eff4le0g	348	11	to	to	IN
cord-265941-eff4le0g	348	12	H.	H.	NNP
cord-265941-eff4le0g	348	13	pylori	pylori	NN
cord-265941-eff4le0g	348	14	-	-	HYPH
cord-265941-eff4le0g	348	15	derived	derive	VBN
cord-265941-eff4le0g	348	16	outer	outer	JJ
cord-265941-eff4le0g	348	17	membrane	membrane	NN
cord-265941-eff4le0g	348	18	vesicles	vesicle	NNS
cord-265941-eff4le0g	348	19	(	(	-LRB-
cord-265941-eff4le0g	348	20	OMVs	omv	NNS
cord-265941-eff4le0g	348	21	)	)	-RRB-
cord-265941-eff4le0g	348	22	containing	contain	VBG
cord-265941-eff4le0g	348	23	PGN	PGN	NNP
cord-265941-eff4le0g	348	24	.	.	.
cord-265941-eff4le0g	349	1	Overall	overall	RB
cord-265941-eff4le0g	349	2	,	,	,
cord-265941-eff4le0g	349	3	NOD1	NOD1	NNP
cord-265941-eff4le0g	349	4	/	/	SYM
cord-265941-eff4le0g	349	5	RIPK2	ripk2	XX
cord-265941-eff4le0g	349	6	signaling	signal	VBG
cord-265941-eff4le0g	349	7	protects	protect	VBZ
cord-265941-eff4le0g	349	8	against	against	IN
cord-265941-eff4le0g	349	9	H.	H.	NNP
cord-265941-eff4le0g	349	10	pylori	pylori	NN
cord-265941-eff4le0g	349	11	infection	infection	NN
cord-265941-eff4le0g	349	12	and	and	CC
cord-265941-eff4le0g	349	13	subsequent	subsequent	JJ
cord-265941-eff4le0g	349	14	malignancies	malignancy	NNS
cord-265941-eff4le0g	349	15	.	.	.
cord-265941-eff4le0g	350	1	NOD2	NOD2	NNP
cord-265941-eff4le0g	351	1	/RIPK2-mediated	/RIPK2-mediated	NNP
cord-265941-eff4le0g	351	2	autophagy	autophagy	VBP
cord-265941-eff4le0g	351	3	aids	aids	NNP
cord-265941-eff4le0g	351	4	in	in	IN
cord-265941-eff4le0g	351	5	the	the	DT
cord-265941-eff4le0g	351	6	control	control	NN
cord-265941-eff4le0g	351	7	of	of	IN
cord-265941-eff4le0g	351	8	a	a	DT
cord-265941-eff4le0g	351	9	number	number	NN
cord-265941-eff4le0g	351	10	of	of	IN
cord-265941-eff4le0g	351	11	pathogens	pathogen	NNS
cord-265941-eff4le0g	351	12	including	include	VBG
cord-265941-eff4le0g	351	13	L.	L.	NNP
cord-265941-eff4le0g	351	14	monocytogenes	monocytogenes	NNP
cord-265941-eff4le0g	351	15	,	,	,
cord-265941-eff4le0g	351	16	S.	S.	NNP
cord-265941-eff4le0g	351	17	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	351	18	and	and	CC
cord-265941-eff4le0g	351	19	Shigella	Shigella	NNP
cord-265941-eff4le0g	351	20	spp	spp	NNS
cord-265941-eff4le0g	351	21	.	.	.
cord-265941-eff4le0g	352	1	[	[	-LRB-
cord-265941-eff4le0g	352	2	183	183	CD
cord-265941-eff4le0g	352	3	]	]	-RRB-
cord-265941-eff4le0g	352	4	.	.	.
cord-265941-eff4le0g	353	1	L.	L.	NNP
cord-265941-eff4le0g	353	2	monocytogenes	monocytogenes	NNP
cord-265941-eff4le0g	353	3	undergoes	undergo	VBZ
cord-265941-eff4le0g	353	4	autophagosomal	autophagosomal	NNP
cord-265941-eff4le0g	353	5	degradation	degradation	NN
cord-265941-eff4le0g	353	6	in	in	IN
cord-265941-eff4le0g	353	7	phagocytic	phagocytic	JJ
cord-265941-eff4le0g	353	8	cells	cell	NNS
cord-265941-eff4le0g	353	9	in	in	IN
cord-265941-eff4le0g	353	10	mouse	mouse	NN
cord-265941-eff4le0g	353	11	BMDMs	bmdm	NNS
cord-265941-eff4le0g	353	12	and	and	CC
cord-265941-eff4le0g	353	13	in	in	IN
cord-265941-eff4le0g	353	14	vivo	vivo	NN
cord-265941-eff4le0g	353	15	via	via	IN
cord-265941-eff4le0g	353	16	ERK	ERK	NNP
cord-265941-eff4le0g	353	17	activation	activation	NN
cord-265941-eff4le0g	353	18	,	,	,
cord-265941-eff4le0g	353	19	in	in	IN
cord-265941-eff4le0g	353	20	a	a	DT
cord-265941-eff4le0g	353	21	process	process	NN
cord-265941-eff4le0g	353	22	mediated	mediate	VBN
cord-265941-eff4le0g	353	23	by	by	IN
cord-265941-eff4le0g	353	24	TLR2	TLR2	NNP
cord-265941-eff4le0g	353	25	,	,	,
cord-265941-eff4le0g	353	26	NOD2	NOD2	NNPS
cord-265941-eff4le0g	353	27	and	and	CC
cord-265941-eff4le0g	353	28	RIPK2	ripk2	XX
cord-265941-eff4le0g	353	29	[	[	-LRB-
cord-265941-eff4le0g	353	30	184	184	CD
cord-265941-eff4le0g	353	31	]	]	-RRB-
cord-265941-eff4le0g	353	32	.	.	.
cord-265941-eff4le0g	354	1	In	in	IN
cord-265941-eff4le0g	354	2	S.	S.	NNP
cord-265941-eff4le0g	354	3	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	354	4	infected	infect	VBD
cord-265941-eff4le0g	354	5	intestinal	intestinal	JJ
cord-265941-eff4le0g	354	6	epithelial	epithelial	JJ
cord-265941-eff4le0g	354	7	cells	cell	NNS
cord-265941-eff4le0g	354	8	,	,	,
cord-265941-eff4le0g	354	9	NOD2	NOD2	NNPS
cord-265941-eff4le0g	354	10	/	/	SYM
cord-265941-eff4le0g	354	11	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	354	12	is	be	VBZ
cord-265941-eff4le0g	354	13	required	require	VBN
cord-265941-eff4le0g	354	14	for	for	IN
cord-265941-eff4le0g	354	15	autophagy	autophagy	NN
cord-265941-eff4le0g	354	16	induction	induction	NN
cord-265941-eff4le0g	354	17	[	[	-LRB-
cord-265941-eff4le0g	354	18	185	185	CD
cord-265941-eff4le0g	354	19	]	]	-RRB-
cord-265941-eff4le0g	354	20	.	.	.
cord-265941-eff4le0g	355	1	This	this	DT
cord-265941-eff4le0g	355	2	in	in	FW
cord-265941-eff4le0g	355	3	vitro	vitro	FW
cord-265941-eff4le0g	355	4	model	model	NN
cord-265941-eff4le0g	355	5	of	of	IN
cord-265941-eff4le0g	355	6	Salmonella	Salmonella	NNP
cord-265941-eff4le0g	355	7	infection	infection	NN
cord-265941-eff4le0g	355	8	demonstrated	demonstrate	VBD
cord-265941-eff4le0g	355	9	a	a	DT
cord-265941-eff4le0g	355	10	dual	dual	JJ
cord-265941-eff4le0g	355	11	role	role	NN
cord-265941-eff4le0g	355	12	for	for	IN
cord-265941-eff4le0g	355	13	RIPK2	ripk2	XX
cord-265941-eff4le0g	355	14	tyrosine	tyrosine	NN
cord-265941-eff4le0g	355	15	kinase	kinase	NN
cord-265941-eff4le0g	355	16	activity	activity	NN
cord-265941-eff4le0g	355	17	in	in	IN
cord-265941-eff4le0g	355	18	NOD2-dependent	NOD2-dependent	NNP
cord-265941-eff4le0g	355	19	autophagy	autophagy	VB
cord-265941-eff4le0g	355	20	through	through	IN
cord-265941-eff4le0g	355	21	activation	activation	NN
cord-265941-eff4le0g	355	22	of	of	IN
cord-265941-eff4le0g	355	23	p38	p38	CD
cord-265941-eff4le0g	355	24	MAPK	MAPK	NNP
cord-265941-eff4le0g	355	25	and	and	CC
cord-265941-eff4le0g	355	26	indirect	indirect	JJ
cord-265941-eff4le0g	355	27	repression	repression	NN
cord-265941-eff4le0g	355	28	of	of	IN
cord-265941-eff4le0g	355	29	PP2A	pp2a	NN
cord-265941-eff4le0g	355	30	phosphatase	phosphatase	NN
cord-265941-eff4le0g	355	31	activity	activity	NN
cord-265941-eff4le0g	355	32	[	[	-LRB-
cord-265941-eff4le0g	355	33	185	185	CD
cord-265941-eff4le0g	355	34	]	]	-RRB-
cord-265941-eff4le0g	355	35	.	.	.
cord-265941-eff4le0g	356	1	In	in	IN
cord-265941-eff4le0g	356	2	addition	addition	NN
cord-265941-eff4le0g	356	3	to	to	IN
cord-265941-eff4le0g	356	4	PGN	PGN	NNP
cord-265941-eff4le0g	356	5	stimulation	stimulation	NN
cord-265941-eff4le0g	356	6	,	,	,
cord-265941-eff4le0g	356	7	there	there	EX
cord-265941-eff4le0g	356	8	is	be	VBZ
cord-265941-eff4le0g	356	9	increasing	increase	VBG
cord-265941-eff4le0g	356	10	evidence	evidence	NN
cord-265941-eff4le0g	356	11	that	that	IN
cord-265941-eff4le0g	356	12	NOD	nod	NN
cord-265941-eff4le0g	356	13	/	/	SYM
cord-265941-eff4le0g	356	14	RIPK2	ripk2	XX
cord-265941-eff4le0g	356	15	signaling	signaling	NN
cord-265941-eff4le0g	356	16	can	can	MD
cord-265941-eff4le0g	356	17	be	be	VB
cord-265941-eff4le0g	356	18	activated	activate	VBN
cord-265941-eff4le0g	356	19	by	by	IN
cord-265941-eff4le0g	356	20	pathogen	pathogen	NN
cord-265941-eff4le0g	356	21	-	-	HYPH
cord-265941-eff4le0g	356	22	induced	induce	VBN
cord-265941-eff4le0g	356	23	modifications	modification	NNS
cord-265941-eff4le0g	356	24	to	to	IN
cord-265941-eff4le0g	356	25	the	the	DT
cord-265941-eff4le0g	356	26	host	host	NN
cord-265941-eff4le0g	356	27	actin	actin	NN
cord-265941-eff4le0g	356	28	cytoskeleton	cytoskeleton	NN
cord-265941-eff4le0g	356	29	[	[	-LRB-
cord-265941-eff4le0g	356	30	186	186	CD
cord-265941-eff4le0g	356	31	]	]	-RRB-
cord-265941-eff4le0g	356	32	[	[	-LRB-
cord-265941-eff4le0g	356	33	187	187	CD
cord-265941-eff4le0g	356	34	]	]	-RRB-
cord-265941-eff4le0g	356	35	[	[	-LRB-
cord-265941-eff4le0g	356	36	188	188	CD
cord-265941-eff4le0g	356	37	]	]	-RRB-
cord-265941-eff4le0g	356	38	[	[	-LRB-
cord-265941-eff4le0g	356	39	189	189	CD
cord-265941-eff4le0g	356	40	]	]	-RRB-
cord-265941-eff4le0g	356	41	.	.	.
cord-265941-eff4le0g	357	1	Cytoskeletal	Cytoskeletal	NNP
cord-265941-eff4le0g	357	2	dynamics	dynamic	NNS
cord-265941-eff4le0g	357	3	are	be	VBP
cord-265941-eff4le0g	357	4	mediated	mediate	VBN
cord-265941-eff4le0g	357	5	via	via	IN
cord-265941-eff4le0g	357	6	a	a	DT
cord-265941-eff4le0g	357	7	balance	balance	NN
cord-265941-eff4le0g	357	8	of	of	IN
cord-265941-eff4le0g	357	9	active	active	JJ
cord-265941-eff4le0g	357	10	GTP	gtp	NN
cord-265941-eff4le0g	357	11	-	-	HYPH
cord-265941-eff4le0g	357	12	bound	bind	VBN
cord-265941-eff4le0g	357	13	and	and	CC
cord-265941-eff4le0g	357	14	inactive	inactive	JJ
cord-265941-eff4le0g	357	15	GDP	gdp	NN
cord-265941-eff4le0g	357	16	-	-	HYPH
cord-265941-eff4le0g	357	17	bound	bind	VBN
cord-265941-eff4le0g	357	18	forms	form	NNS
cord-265941-eff4le0g	357	19	of	of	IN
cord-265941-eff4le0g	357	20	small	small	JJ
cord-265941-eff4le0g	357	21	Rho	rho	NN
cord-265941-eff4le0g	357	22	GTPases	gtpase	NNS
cord-265941-eff4le0g	357	23	[	[	-LRB-
cord-265941-eff4le0g	357	24	190	190	CD
cord-265941-eff4le0g	357	25	]	]	-RRB-
cord-265941-eff4le0g	357	26	.	.	.
cord-265941-eff4le0g	358	1	Salmonella	Salmonella	NNP
cord-265941-eff4le0g	358	2	and	and	CC
cord-265941-eff4le0g	358	3	Shigella	Shigella	NNP
cord-265941-eff4le0g	358	4	spp	spp	NNS
cord-265941-eff4le0g	358	5	.	.	.
cord-265941-eff4le0g	359	1	utilise	utilise	VB
cord-265941-eff4le0g	359	2	T3SS	T3SS	NNP
cord-265941-eff4le0g	359	3	to	to	TO
cord-265941-eff4le0g	359	4	translocate	translocate	VB
cord-265941-eff4le0g	359	5	bacterial	bacterial	JJ
cord-265941-eff4le0g	359	6	effector	effector	NN
cord-265941-eff4le0g	359	7	proteins	protein	NNS
cord-265941-eff4le0g	359	8	into	into	IN
cord-265941-eff4le0g	359	9	host	host	NN
cord-265941-eff4le0g	359	10	cells	cell	NNS
cord-265941-eff4le0g	359	11	,	,	,
cord-265941-eff4le0g	359	12	and	and	CC
cord-265941-eff4le0g	359	13	manipulate	manipulate	VB
cord-265941-eff4le0g	359	14	host	host	NN
cord-265941-eff4le0g	359	15	cytoskeletal	cytoskeletal	JJ
cord-265941-eff4le0g	359	16	proteins	protein	NNS
cord-265941-eff4le0g	359	17	and	and	CC
cord-265941-eff4le0g	359	18	innate	innate	JJ
cord-265941-eff4le0g	359	19	immune	immune	JJ
cord-265941-eff4le0g	359	20	responses	response	NNS
cord-265941-eff4le0g	359	21	[	[	-LRB-
cord-265941-eff4le0g	359	22	191	191	CD
cord-265941-eff4le0g	359	23	]	]	-RRB-
cord-265941-eff4le0g	359	24	.	.	.
cord-265941-eff4le0g	360	1	Shigella	Shigella	NNP
cord-265941-eff4le0g	360	2	infection	infection	NN
cord-265941-eff4le0g	360	3	induces	induce	VBZ
cord-265941-eff4le0g	360	4	the	the	DT
cord-265941-eff4le0g	360	5	recruitment	recruitment	NN
cord-265941-eff4le0g	360	6	of	of	IN
cord-265941-eff4le0g	360	7	GEF	GEF	NNP
cord-265941-eff4le0g	360	8	-	-	HYPH
cord-265941-eff4le0g	360	9	H1	H1	NNP
cord-265941-eff4le0g	360	10	,	,	,
cord-265941-eff4le0g	360	11	a	a	DT
cord-265941-eff4le0g	360	12	guanidine	guanidine	NN
cord-265941-eff4le0g	360	13	exchange	exchange	NN
cord-265941-eff4le0g	360	14	factor	factor	NN
cord-265941-eff4le0g	360	15	(	(	-LRB-
cord-265941-eff4le0g	360	16	GEF	GEF	NNP
cord-265941-eff4le0g	360	17	)	)	-RRB-
cord-265941-eff4le0g	360	18	for	for	IN
cord-265941-eff4le0g	360	19	the	the	DT
cord-265941-eff4le0g	360	20	small	small	JJ
cord-265941-eff4le0g	360	21	Rho	Rho	NNP
cord-265941-eff4le0g	360	22	GTPase	GTPase	NNP
cord-265941-eff4le0g	360	23	RhoA	RhoA	NNP
cord-265941-eff4le0g	360	24	,	,	,
cord-265941-eff4le0g	360	25	to	to	IN
cord-265941-eff4le0g	360	26	the	the	DT
cord-265941-eff4le0g	360	27	site	site	NN
cord-265941-eff4le0g	360	28	of	of	IN
cord-265941-eff4le0g	360	29	invasion	invasion	NN
cord-265941-eff4le0g	360	30	to	to	TO
cord-265941-eff4le0g	360	31	promote	promote	VB
cord-265941-eff4le0g	360	32	host	host	NN
cord-265941-eff4le0g	360	33	cell	cell	NN
cord-265941-eff4le0g	360	34	entry	entry	NN
cord-265941-eff4le0g	360	35	.	.	.
cord-265941-eff4le0g	361	1	Following	follow	VBG
cord-265941-eff4le0g	361	2	invasion	invasion	NN
cord-265941-eff4le0g	361	3	,	,	,
cord-265941-eff4le0g	361	4	the	the	DT
cord-265941-eff4le0g	361	5	Shigella	Shigella	NNP
cord-265941-eff4le0g	361	6	effectors	effector	NNS
cord-265941-eff4le0g	361	7	IpgB2	IpgB2	NNP
cord-265941-eff4le0g	361	8	and	and	CC
cord-265941-eff4le0g	361	9	OspB	OspB	NNP
cord-265941-eff4le0g	361	10	induce	induce	VBP
cord-265941-eff4le0g	361	11	RIPK2-dependent	RIPK2-dependent	NNP
cord-265941-eff4le0g	361	12	NF	NF	NNP
cord-265941-eff4le0g	361	13	-	-	HYPH
cord-265941-eff4le0g	361	14	κB	κb	CD
cord-265941-eff4le0g	361	15	activation	activation	NN
cord-265941-eff4le0g	361	16	mediated	mediate	VBN
cord-265941-eff4le0g	361	17	by	by	IN
cord-265941-eff4le0g	361	18	the	the	DT
cord-265941-eff4le0g	361	19	interaction	interaction	NN
cord-265941-eff4le0g	361	20	of	of	IN
cord-265941-eff4le0g	361	21	recruited	recruit	VBN
cord-265941-eff4le0g	361	22	GEF	GEF	NNP
cord-265941-eff4le0g	361	23	-	-	HYPH
cord-265941-eff4le0g	361	24	H1	H1	NNP
cord-265941-eff4le0g	361	25	with	with	IN
cord-265941-eff4le0g	361	26	NOD1	NOD1	NNP
cord-265941-eff4le0g	361	27	[	[	-LRB-
cord-265941-eff4le0g	361	28	187	187	CD
cord-265941-eff4le0g	361	29	]	]	-RRB-
cord-265941-eff4le0g	361	30	.	.	.
cord-265941-eff4le0g	362	1	The	the	DT
cord-265941-eff4le0g	362	2	S.	S.	NNP
cord-265941-eff4le0g	362	3	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	362	4	effector	effector	NN
cord-265941-eff4le0g	362	5	SipA	SipA	NNP
cord-265941-eff4le0g	362	6	drives	drive	VBZ
cord-265941-eff4le0g	362	7	NOD1/	NOD1/	NNP
cord-265941-eff4le0g	363	1	NOD2	NOD2	NNP
cord-265941-eff4le0g	363	2	/	/	SYM
cord-265941-eff4le0g	363	3	RIPK2	ripk2	XX
cord-265941-eff4le0g	364	1	dependent	dependent	JJ
cord-265941-eff4le0g	364	2	NFκB	NFκB	NNP
cord-265941-eff4le0g	364	3	activation	activation	NN
cord-265941-eff4le0g	364	4	via	via	IN
cord-265941-eff4le0g	364	5	an	an	DT
cord-265941-eff4le0g	364	6	unknown	unknown	JJ
cord-265941-eff4le0g	364	7	mechanism	mechanism	NN
cord-265941-eff4le0g	364	8	[	[	-LRB-
cord-265941-eff4le0g	364	9	189	189	CD
cord-265941-eff4le0g	364	10	]	]	-RRB-
cord-265941-eff4le0g	364	11	,	,	,
cord-265941-eff4le0g	364	12	whereas	whereas	RB
cord-265941-eff4le0g	364	13	,	,	,
cord-265941-eff4le0g	364	14	SopE	SopE	NNP
cord-265941-eff4le0g	364	15	,	,	,
cord-265941-eff4le0g	364	16	functions	function	NNS
cord-265941-eff4le0g	364	17	as	as	IN
cord-265941-eff4le0g	364	18	a	a	DT
cord-265941-eff4le0g	364	19	GEF	gef	NN
cord-265941-eff4le0g	364	20	for	for	IN
cord-265941-eff4le0g	364	21	the	the	DT
cord-265941-eff4le0g	364	22	small	small	JJ
cord-265941-eff4le0g	364	23	Rho	rho	NN
cord-265941-eff4le0g	364	24	GTPases	GTPases	NNP
cord-265941-eff4le0g	364	25	Rac1	Rac1	NNP
cord-265941-eff4le0g	364	26	and	and	CC
cord-265941-eff4le0g	364	27	Cdc42	Cdc42	NNP
cord-265941-eff4le0g	364	28	.	.	.
cord-265941-eff4le0g	365	1	In	in	IN
cord-265941-eff4le0g	365	2	this	this	DT
cord-265941-eff4le0g	365	3	setting	setting	NN
cord-265941-eff4le0g	365	4	,	,	,
cord-265941-eff4le0g	365	5	Rac1	Rac1	NNP
cord-265941-eff4le0g	365	6	and	and	CC
cord-265941-eff4le0g	365	7	Cdc42	Cdc42	NNP
cord-265941-eff4le0g	365	8	interact	interact	VBP
cord-265941-eff4le0g	365	9	with	with	IN
cord-265941-eff4le0g	365	10	the	the	DT
cord-265941-eff4le0g	365	11	NOD1/	NOD1/	NNP
cord-265941-eff4le0g	366	1	RIPK2	ripk2	DT
cord-265941-eff4le0g	366	2	signaling	signal	VBG
cord-265941-eff4le0g	366	3	complex	complex	NN
cord-265941-eff4le0g	366	4	in	in	IN
cord-265941-eff4le0g	366	5	the	the	DT
cord-265941-eff4le0g	366	6	absence	absence	NN
cord-265941-eff4le0g	366	7	of	of	IN
cord-265941-eff4le0g	366	8	PGN	PGN	NNP
cord-265941-eff4le0g	366	9	to	to	TO
cord-265941-eff4le0g	366	10	mediate	mediate	VB
cord-265941-eff4le0g	366	11	NF	nf	NN
cord-265941-eff4le0g	366	12	-	-	HYPH
cord-265941-eff4le0g	366	13	κB	κB	NNP
cord-265941-eff4le0g	366	14	-	-	HYPH
cord-265941-eff4le0g	366	15	dependent	dependent	JJ
cord-265941-eff4le0g	366	16	inflammation	inflammation	NN
cord-265941-eff4le0g	366	17	[	[	-LRB-
cord-265941-eff4le0g	366	18	188	188	CD
cord-265941-eff4le0g	366	19	]	]	-RRB-
cord-265941-eff4le0g	366	20	.	.	.
cord-265941-eff4le0g	367	1	In	in	IN
cord-265941-eff4le0g	367	2	addition	addition	NN
cord-265941-eff4le0g	367	3	,	,	,
cord-265941-eff4le0g	367	4	the	the	DT
cord-265941-eff4le0g	367	5	Escherichia	Escherichia	NNP
cord-265941-eff4le0g	367	6	coli	coli	NNS
cord-265941-eff4le0g	367	7	cytotoxic	cytotoxic	JJ
cord-265941-eff4le0g	367	8	necrotising	necrotising	NN
cord-265941-eff4le0g	367	9	factor	factor	NN
cord-265941-eff4le0g	367	10	1	1	CD
cord-265941-eff4le0g	367	11	(	(	-LRB-
cord-265941-eff4le0g	367	12	CNF1	CNF1	NNP
cord-265941-eff4le0g	367	13	)	)	-RRB-
cord-265941-eff4le0g	367	14	activates	activate	VBZ
cord-265941-eff4le0g	367	15	the	the	DT
cord-265941-eff4le0g	367	16	small	small	JJ
cord-265941-eff4le0g	367	17	Rho	rho	NN
cord-265941-eff4le0g	367	18	GTPase	GTPase	NNP
cord-265941-eff4le0g	367	19	Rac2	Rac2	NNP
cord-265941-eff4le0g	367	20	,	,	,
cord-265941-eff4le0g	367	21	which	which	WDT
cord-265941-eff4le0g	367	22	then	then	RB
cord-265941-eff4le0g	367	23	interacts	interact	VBZ
cord-265941-eff4le0g	367	24	with	with	IN
cord-265941-eff4le0g	367	25	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	367	26	and	and	CC
cord-265941-eff4le0g	367	27	RIPK2	ripk2	XX
cord-265941-eff4le0g	367	28	to	to	TO
cord-265941-eff4le0g	367	29	induce	induce	VB
cord-265941-eff4le0g	367	30	a	a	DT
cord-265941-eff4le0g	367	31	potent	potent	JJ
cord-265941-eff4le0g	367	32	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	367	33	response	response	NN
cord-265941-eff4le0g	367	34	,	,	,
cord-265941-eff4le0g	367	35	independent	independent	JJ
cord-265941-eff4le0g	367	36	of	of	IN
cord-265941-eff4le0g	367	37	NOD1/2	NOD1/2	NNP
cord-265941-eff4le0g	367	38	[	[	-LRB-
cord-265941-eff4le0g	367	39	192	192	CD
cord-265941-eff4le0g	367	40	]	]	-RRB-
cord-265941-eff4le0g	367	41	.	.	.
cord-265941-eff4le0g	368	1	Many	many	JJ
cord-265941-eff4le0g	368	2	other	other	JJ
cord-265941-eff4le0g	368	3	bacterial	bacterial	JJ
cord-265941-eff4le0g	368	4	pathogens	pathogen	NNS
cord-265941-eff4le0g	368	5	have	have	VBP
cord-265941-eff4le0g	368	6	also	also	RB
cord-265941-eff4le0g	368	7	been	be	VBN
cord-265941-eff4le0g	368	8	shown	show	VBN
cord-265941-eff4le0g	368	9	to	to	TO
cord-265941-eff4le0g	368	10	induce	induce	VB
cord-265941-eff4le0g	368	11	changes	change	NNS
cord-265941-eff4le0g	368	12	to	to	IN
cord-265941-eff4le0g	368	13	Rho	Rho	NNP
cord-265941-eff4le0g	368	14	GTPases	gtpase	NNS
cord-265941-eff4le0g	368	15	[	[	-LRB-
cord-265941-eff4le0g	368	16	193	193	CD
cord-265941-eff4le0g	368	17	]	]	-RRB-
cord-265941-eff4le0g	368	18	,	,	,
cord-265941-eff4le0g	368	19	overall	overall	RB
cord-265941-eff4le0g	368	20	highlighting	highlight	VBG
cord-265941-eff4le0g	368	21	the	the	DT
cord-265941-eff4le0g	368	22	role	role	NN
cord-265941-eff4le0g	368	23	of	of	IN
cord-265941-eff4le0g	368	24	pathogen	pathogen	NN
cord-265941-eff4le0g	368	25	-	-	HYPH
cord-265941-eff4le0g	368	26	induced	induce	VBN
cord-265941-eff4le0g	368	27	small	small	JJ
cord-265941-eff4le0g	368	28	Rho	Rho	NNP
cord-265941-eff4le0g	368	29	GTPase	GTPase	NNP
cord-265941-eff4le0g	368	30	activation	activation	NN
cord-265941-eff4le0g	368	31	in	in	IN
cord-265941-eff4le0g	368	32	NOD1/	NOD1/	NNP
cord-265941-eff4le0g	369	1	RIPK2-mediated	ripk2-mediate	VBN
cord-265941-eff4le0g	369	2	inflammation	inflammation	NN
cord-265941-eff4le0g	369	3	.	.	.
cord-265941-eff4le0g	370	1	Pathogen	pathogen	NN
cord-265941-eff4le0g	370	2	-	-	HYPH
cord-265941-eff4le0g	370	3	activated	activate	VBN
cord-265941-eff4le0g	370	4	endoplasmic	endoplasmic	NN
cord-265941-eff4le0g	370	5	reticulum	reticulum	NN
cord-265941-eff4le0g	370	6	(	(	-LRB-
cord-265941-eff4le0g	370	7	ER)-stress	er)-stress	NN
cord-265941-eff4le0g	370	8	also	also	RB
cord-265941-eff4le0g	370	9	drives	drive	VBZ
cord-265941-eff4le0g	370	10	NOD	nod	VBP
cord-265941-eff4le0g	370	11	/	/	SYM
cord-265941-eff4le0g	370	12	RIPK2-induced	ripk2-induced	CD
cord-265941-eff4le0g	370	13	inflammation	inflammation	NN
cord-265941-eff4le0g	370	14	[	[	-LRB-
cord-265941-eff4le0g	370	15	194	194	CD
cord-265941-eff4le0g	370	16	]	]	-RRB-
cord-265941-eff4le0g	370	17	.	.	.
cord-265941-eff4le0g	371	1	The	the	DT
cord-265941-eff4le0g	371	2	intracellular	intracellular	JJ
cord-265941-eff4le0g	371	3	pathogen	pathogen	NN
cord-265941-eff4le0g	371	4	Brucella	Brucella	NNP
cord-265941-eff4le0g	371	5	abortus	abortus	NN
cord-265941-eff4le0g	371	6	induces	induce	VBZ
cord-265941-eff4le0g	371	7	ER	ER	NNP
cord-265941-eff4le0g	371	8	stress	stress	NN
cord-265941-eff4le0g	371	9	via	via	IN
cord-265941-eff4le0g	371	10	the	the	DT
cord-265941-eff4le0g	371	11	IRE1	IRE1	NNP
cord-265941-eff4le0g	371	12	⍺	⍺	NN
cord-265941-eff4le0g	371	13	pathway	pathway	NN
cord-265941-eff4le0g	371	14	of	of	IN
cord-265941-eff4le0g	371	15	the	the	DT
cord-265941-eff4le0g	371	16	unfolded	unfolded	JJ
cord-265941-eff4le0g	371	17	protein	protein	NN
cord-265941-eff4le0g	371	18	response	response	NN
cord-265941-eff4le0g	371	19	(	(	-LRB-
cord-265941-eff4le0g	371	20	UPR	UPR	NNP
cord-265941-eff4le0g	371	21	)	)	-RRB-
cord-265941-eff4le0g	371	22	.	.	.
cord-265941-eff4le0g	372	1	IRE1	IRE1	NNP
cord-265941-eff4le0g	372	2	⍺	⍺	NNS
cord-265941-eff4le0g	372	3	acts	act	VBZ
cord-265941-eff4le0g	372	4	as	as	IN
cord-265941-eff4le0g	372	5	a	a	DT
cord-265941-eff4le0g	372	6	receptor	receptor	NN
cord-265941-eff4le0g	372	7	that	that	WDT
cord-265941-eff4le0g	372	8	is	be	VBZ
cord-265941-eff4le0g	372	9	stimulated	stimulate	VBN
cord-265941-eff4le0g	372	10	upon	upon	IN
cord-265941-eff4le0g	372	11	binding	bind	VBG
cord-265941-eff4le0g	372	12	of	of	IN
cord-265941-eff4le0g	372	13	the	the	DT
cord-265941-eff4le0g	372	14	Brucella	Brucella	NNP
cord-265941-eff4le0g	372	15	T4SS	T4SS	NNP
cord-265941-eff4le0g	372	16	effector	effector	NN
cord-265941-eff4le0g	372	17	VceC	VceC	NNS
cord-265941-eff4le0g	372	18	to	to	IN
cord-265941-eff4le0g	372	19	the	the	DT
cord-265941-eff4le0g	372	20	ER	ER	NNP
cord-265941-eff4le0g	372	21	chaperone	chaperone	NN
cord-265941-eff4le0g	372	22	BiP	bip	NN
cord-265941-eff4le0g	372	23	,	,	,
cord-265941-eff4le0g	372	24	and	and	CC
cord-265941-eff4le0g	372	25	subsequently	subsequently	RB
cord-265941-eff4le0g	372	26	recruits	recruit	VBZ
cord-265941-eff4le0g	372	27	TRAF2	traf2	XX
cord-265941-eff4le0g	372	28	to	to	TO
cord-265941-eff4le0g	372	29	activate	activate	VB
cord-265941-eff4le0g	372	30	NOD2	NOD2	NNP
cord-265941-eff4le0g	372	31	/	/	SYM
cord-265941-eff4le0g	372	32	RIPK2-mediated	ripk2-mediate	VBN
cord-265941-eff4le0g	372	33	NF	NF	NNP
cord-265941-eff4le0g	372	34	-	-	HYPH
cord-265941-eff4le0g	372	35	κB	κb	CD
cord-265941-eff4le0g	372	36	activation	activation	NN
cord-265941-eff4le0g	372	37	[	[	-LRB-
cord-265941-eff4le0g	372	38	194	194	CD
cord-265941-eff4le0g	372	39	]	]	-RRB-
cord-265941-eff4le0g	372	40	.	.	.
cord-265941-eff4le0g	373	1	Although	although	IN
cord-265941-eff4le0g	373	2	the	the	DT
cord-265941-eff4le0g	373	3	precise	precise	JJ
cord-265941-eff4le0g	373	4	mechanism	mechanism	NN
cord-265941-eff4le0g	373	5	is	be	VBZ
cord-265941-eff4le0g	373	6	not	not	RB
cord-265941-eff4le0g	373	7	yet	yet	RB
cord-265941-eff4le0g	373	8	established	establish	VBN
cord-265941-eff4le0g	373	9	,	,	,
cord-265941-eff4le0g	373	10	the	the	DT
cord-265941-eff4le0g	373	11	intracellular	intracellular	JJ
cord-265941-eff4le0g	373	12	pathogen	pathogen	NN
cord-265941-eff4le0g	373	13	Chlamydia	Chlamydia	NNP
cord-265941-eff4le0g	373	14	muridarum	muridarum	NNP
cord-265941-eff4le0g	373	15	also	also	RB
cord-265941-eff4le0g	373	16	induces	induce	VBZ
cord-265941-eff4le0g	373	17	NOD1/-NOD2	NOD1/-NOD2	NNP
cord-265941-eff4le0g	373	18	/	/	SYM
cord-265941-eff4le0g	373	19	RIPK2	ripk2	XX
cord-265941-eff4le0g	373	20	signaling	signal	VBG
cord-265941-eff4le0g	373	21	in	in	IN
cord-265941-eff4le0g	373	22	response	response	NN
cord-265941-eff4le0g	373	23	to	to	IN
cord-265941-eff4le0g	373	24	ER	ER	NNP
cord-265941-eff4le0g	373	25	stress	stress	NN
cord-265941-eff4le0g	373	26	in	in	IN
cord-265941-eff4le0g	373	27	vitro	vitro	FW
cord-265941-eff4le0g	373	28	[	[	-LRB-
cord-265941-eff4le0g	373	29	194	194	CD
cord-265941-eff4le0g	373	30	]	]	-RRB-
cord-265941-eff4le0g	373	31	,	,	.
cord-265941-eff4le0g	374	1	however	however	RB
cord-265941-eff4le0g	374	2	in	in	IN
cord-265941-eff4le0g	374	3	vivo	vivo	NNP
cord-265941-eff4le0g	374	4	studies	study	NNS
cord-265941-eff4le0g	374	5	have	have	VBP
cord-265941-eff4le0g	374	6	shown	show	VBN
cord-265941-eff4le0g	374	7	that	that	IN
cord-265941-eff4le0g	374	8	RIPK2	ripk2	DT
cord-265941-eff4le0g	374	9	deletion	deletion	NN
cord-265941-eff4le0g	374	10	has	have	VBZ
cord-265941-eff4le0g	374	11	a	a	DT
cord-265941-eff4le0g	374	12	limited	limited	JJ
cord-265941-eff4le0g	374	13	effect	effect	NN
cord-265941-eff4le0g	374	14	on	on	IN
cord-265941-eff4le0g	374	15	chlamydial	chlamydial	JJ
cord-265941-eff4le0g	374	16	infection	infection	NN
cord-265941-eff4le0g	374	17	in	in	IN
cord-265941-eff4le0g	374	18	terms	term	NNS
cord-265941-eff4le0g	374	19	of	of	IN
cord-265941-eff4le0g	374	20	bacterial	bacterial	JJ
cord-265941-eff4le0g	374	21	burden	burden	NN
cord-265941-eff4le0g	374	22	,	,	,
cord-265941-eff4le0g	374	23	immune	immune	JJ
cord-265941-eff4le0g	374	24	responses	response	NNS
cord-265941-eff4le0g	374	25	and	and	CC
cord-265941-eff4le0g	374	26	pathology	pathology	NN
cord-265941-eff4le0g	374	27	[	[	-LRB-
cord-265941-eff4le0g	374	28	195	195	CD
cord-265941-eff4le0g	374	29	]	]	-RRB-
cord-265941-eff4le0g	374	30	.	.	.
cord-265941-eff4le0g	375	1	Given	give	VBN
cord-265941-eff4le0g	375	2	that	that	IN
cord-265941-eff4le0g	375	3	many	many	JJ
cord-265941-eff4le0g	375	4	pathogens	pathogen	NNS
cord-265941-eff4le0g	375	5	including	include	VBG
cord-265941-eff4le0g	375	6	IAV	IAV	NNP
cord-265941-eff4le0g	375	7	[	[	-LRB-
cord-265941-eff4le0g	375	8	196	196	CD
cord-265941-eff4le0g	375	9	]	]	-RRB-
cord-265941-eff4le0g	375	10	and	and	CC
cord-265941-eff4le0g	375	11	HCMV	HCMV	NNP
cord-265941-eff4le0g	375	12	[	[	-LRB-
cord-265941-eff4le0g	375	13	197	197	CD
cord-265941-eff4le0g	375	14	]	]	-RRB-
cord-265941-eff4le0g	375	15	activate	activate	VBP
cord-265941-eff4le0g	375	16	ER	ER	NNP
cord-265941-eff4le0g	375	17	-	-	HYPH
cord-265941-eff4le0g	375	18	stress	stress	NN
cord-265941-eff4le0g	375	19	followed	follow	VBN
cord-265941-eff4le0g	375	20	by	by	IN
cord-265941-eff4le0g	375	21	induction	induction	NN
cord-265941-eff4le0g	375	22	of	of	IN
cord-265941-eff4le0g	375	23	the	the	DT
cord-265941-eff4le0g	375	24	UPR	UPR	NNP
cord-265941-eff4le0g	375	25	,	,	,
cord-265941-eff4le0g	375	26	it	-PRON-	PRP
cord-265941-eff4le0g	375	27	could	could	MD
cord-265941-eff4le0g	375	28	be	be	VB
cord-265941-eff4le0g	375	29	likely	likely	JJ
cord-265941-eff4le0g	375	30	that	that	IN
cord-265941-eff4le0g	375	31	NOD	nod	NN
cord-265941-eff4le0g	375	32	/	/	SYM
cord-265941-eff4le0g	375	33	RIPK2	ripk2	XX
cord-265941-eff4le0g	375	34	signaling	signaling	NN
cord-265941-eff4le0g	375	35	has	have	VBZ
cord-265941-eff4le0g	375	36	an	an	DT
cord-265941-eff4le0g	375	37	underappreciated	underappreciated	JJ
cord-265941-eff4le0g	375	38	role	role	NN
cord-265941-eff4le0g	375	39	in	in	IN
cord-265941-eff4le0g	375	40	host	host	NN
cord-265941-eff4le0g	375	41	immunity	immunity	NN
cord-265941-eff4le0g	375	42	via	via	IN
cord-265941-eff4le0g	375	43	this	this	DT
cord-265941-eff4le0g	375	44	pathogen	pathogen	NN
cord-265941-eff4le0g	375	45	-	-	HYPH
cord-265941-eff4le0g	375	46	induced	induce	VBN
cord-265941-eff4le0g	375	47	mechanism	mechanism	NN
cord-265941-eff4le0g	375	48	.	.	.
cord-265941-eff4le0g	376	1	Regulation	regulation	NN
cord-265941-eff4le0g	376	2	of	of	IN
cord-265941-eff4le0g	376	3	RIPK2-mediated	ripk2-mediated	JJ
cord-265941-eff4le0g	376	4	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	376	5	responses	response	NNS
cord-265941-eff4le0g	376	6	to	to	IN
cord-265941-eff4le0g	376	7	infection	infection	NN
cord-265941-eff4le0g	376	8	is	be	VBZ
cord-265941-eff4le0g	376	9	dependent	dependent	JJ
cord-265941-eff4le0g	376	10	upon	upon	IN
cord-265941-eff4le0g	376	11	the	the	DT
cord-265941-eff4le0g	376	12	deubiquitinating	deubiquitinating	NN
cord-265941-eff4le0g	376	13	enzyme	enzyme	NN
cord-265941-eff4le0g	377	1	CYLD	CYLD	NNP
cord-265941-eff4le0g	377	2	[	[	-LRB-
cord-265941-eff4le0g	377	3	198	198	CD
cord-265941-eff4le0g	377	4	]	]	-RRB-
cord-265941-eff4le0g	377	5	.	.	.
cord-265941-eff4le0g	378	1	During	during	IN
cord-265941-eff4le0g	378	2	in	in	FW
cord-265941-eff4le0g	378	3	vitro	vitro	FW
cord-265941-eff4le0g	378	4	infection	infection	NN
cord-265941-eff4le0g	378	5	of	of	IN
cord-265941-eff4le0g	378	6	mouse	mouse	NN
cord-265941-eff4le0g	378	7	bone	bone	NN
cord-265941-eff4le0g	378	8	marrow	marrow	NN
cord-265941-eff4le0g	378	9	-	-	HYPH
cord-265941-eff4le0g	378	10	derived	derive	VBN
cord-265941-eff4le0g	378	11	macrophages	macrophage	NNS
cord-265941-eff4le0g	378	12	(	(	-LRB-
cord-265941-eff4le0g	378	13	BMDMs	bmdm	NNS
cord-265941-eff4le0g	378	14	)	)	-RRB-
cord-265941-eff4le0g	378	15	with	with	IN
cord-265941-eff4le0g	378	16	L.	L.	NNP
cord-265941-eff4le0g	378	17	monocytogenes	monocytogenes	NNP
cord-265941-eff4le0g	378	18	,	,	,
cord-265941-eff4le0g	378	19	CYLD	CYLD	NNP
cord-265941-eff4le0g	378	20	binds	bind	VBZ
cord-265941-eff4le0g	378	21	and	and	CC
cord-265941-eff4le0g	378	22	deubiquitylates	deubiquitylate	NNS
cord-265941-eff4le0g	378	23	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	378	24	,	,	,
cord-265941-eff4le0g	378	25	resulting	result	VBG
cord-265941-eff4le0g	378	26	in	in	IN
cord-265941-eff4le0g	378	27	decreased	decreased	JJ
cord-265941-eff4le0g	378	28	activation	activation	NN
cord-265941-eff4le0g	378	29	of	of	IN
cord-265941-eff4le0g	378	30	NF	nf	NN
cord-265941-eff4le0g	378	31	-	-	HYPH
cord-265941-eff4le0g	378	32	κB	κB	NNP
cord-265941-eff4le0g	378	33	and	and	CC
cord-265941-eff4le0g	378	34	ERK1/2	ERK1/2	NNP
cord-265941-eff4le0g	378	35	signaling	signal	VBG
cord-265941-eff4le0g	378	36	.	.	.
cord-265941-eff4le0g	379	1	Thus	thus	RB
cord-265941-eff4le0g	379	2	,	,	,
cord-265941-eff4le0g	379	3	inhibition	inhibition	NN
cord-265941-eff4le0g	379	4	of	of	IN
cord-265941-eff4le0g	379	5	RIPK2	ripk2	XX
cord-265941-eff4le0g	379	6	by	by	IN
cord-265941-eff4le0g	379	7	CYLD	CYLD	NNP
cord-265941-eff4le0g	379	8	leads	lead	VBZ
cord-265941-eff4le0g	379	9	to	to	IN
cord-265941-eff4le0g	379	10	impaired	impaired	JJ
cord-265941-eff4le0g	379	11	pathogen	pathogen	NN
cord-265941-eff4le0g	379	12	control	control	NN
cord-265941-eff4le0g	379	13	due	due	IN
cord-265941-eff4le0g	379	14	to	to	IN
cord-265941-eff4le0g	379	15	a	a	DT
cord-265941-eff4le0g	379	16	reduction	reduction	NN
cord-265941-eff4le0g	379	17	in	in	IN
cord-265941-eff4le0g	379	18	antimicrobial	antimicrobial	JJ
cord-265941-eff4le0g	379	19	responses	response	NNS
cord-265941-eff4le0g	379	20	including	include	VBG
cord-265941-eff4le0g	379	21	pro	pro	JJ
cord-265941-eff4le0g	379	22	-	-	JJ
cord-265941-eff4le0g	379	23	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	379	24	cytokine	cytokine	NN
cord-265941-eff4le0g	379	25	production	production	NN
cord-265941-eff4le0g	379	26	,	,	,
cord-265941-eff4le0g	379	27	ROS	ROS	NNP
cord-265941-eff4le0g	379	28	and	and	CC
cord-265941-eff4le0g	379	29	nitric	nitric	NN
cord-265941-eff4le0g	379	30	oxide	oxide	NN
cord-265941-eff4le0g	379	31	(	(	-LRB-
cord-265941-eff4le0g	379	32	NO	no	UH
cord-265941-eff4le0g	379	33	)	)	-RRB-
cord-265941-eff4le0g	379	34	production	production	NN
cord-265941-eff4le0g	379	35	.	.	.
cord-265941-eff4le0g	380	1	Another	another	DT
cord-265941-eff4le0g	380	2	recent	recent	JJ
cord-265941-eff4le0g	380	3	study	study	NN
cord-265941-eff4le0g	380	4	used	use	VBD
cord-265941-eff4le0g	380	5	kinase	kinase	NN
cord-265941-eff4le0g	380	6	inhibitors	inhibitor	NNS
cord-265941-eff4le0g	380	7	to	to	TO
cord-265941-eff4le0g	380	8	demonstrate	demonstrate	VB
cord-265941-eff4le0g	380	9	functional	functional	JJ
cord-265941-eff4le0g	380	10	specificity	specificity	NN
cord-265941-eff4le0g	380	11	of	of	IN
cord-265941-eff4le0g	380	12	the	the	DT
cord-265941-eff4le0g	380	13	kinase	kinase	NN
cord-265941-eff4le0g	380	14	domain	domain	NN
cord-265941-eff4le0g	380	15	of	of	IN
cord-265941-eff4le0g	380	16	RIPK2	ripk2	NN
cord-265941-eff4le0g	380	17	in	in	IN
cord-265941-eff4le0g	380	18	controlling	control	VBG
cord-265941-eff4le0g	380	19	bacterial	bacterial	JJ
cord-265941-eff4le0g	380	20	pathogens	pathogen	NNS
cord-265941-eff4le0g	380	21	.	.	.
cord-265941-eff4le0g	381	1	WEHI-345	WEHI-345	NNP
cord-265941-eff4le0g	381	2	is	be	VBZ
cord-265941-eff4le0g	381	3	a	a	DT
cord-265941-eff4le0g	381	4	potent	potent	JJ
cord-265941-eff4le0g	381	5	inhibitor	inhibitor	NN
cord-265941-eff4le0g	381	6	of	of	IN
cord-265941-eff4le0g	381	7	RIPK2	ripk2	XX
cord-265941-eff4le0g	382	1	that	that	IN
cord-265941-eff4le0g	382	2	specifically	specifically	RB
cord-265941-eff4le0g	382	3	targets	target	VBZ
cord-265941-eff4le0g	382	4	serine	serine	NN
cord-265941-eff4le0g	382	5	/	/	SYM
cord-265941-eff4le0g	382	6	threonine	threonine	NN
cord-265941-eff4le0g	382	7	kinase	kinase	NN
cord-265941-eff4le0g	382	8	activity	activity	NN
cord-265941-eff4le0g	382	9	[	[	-LRB-
cord-265941-eff4le0g	382	10	146	146	CD
cord-265941-eff4le0g	382	11	]	]	-RRB-
cord-265941-eff4le0g	382	12	and	and	CC
cord-265941-eff4le0g	382	13	pre	pre	JJ
cord-265941-eff4le0g	382	14	-	-	JJ
cord-265941-eff4le0g	382	15	treatment	treatment	NN
cord-265941-eff4le0g	382	16	of	of	IN
cord-265941-eff4le0g	382	17	CD11β	CD11β	NNP
cord-265941-eff4le0g	382	18	+	+	CC
cord-265941-eff4le0g	382	19	monocytes	monocyte	NNS
cord-265941-eff4le0g	382	20	with	with	IN
cord-265941-eff4le0g	382	21	this	this	DT
cord-265941-eff4le0g	382	22	inhibitor	inhibitor	NN
cord-265941-eff4le0g	382	23	significantly	significantly	RB
cord-265941-eff4le0g	382	24	reduces	reduce	VBZ
cord-265941-eff4le0g	382	25	TNF	tnf	NN
cord-265941-eff4le0g	382	26	production	production	NN
cord-265941-eff4le0g	382	27	during	during	IN
cord-265941-eff4le0g	382	28	in	in	IN
cord-265941-eff4le0g	382	29	vitro	vitro	FW
cord-265941-eff4le0g	382	30	infection	infection	NN
cord-265941-eff4le0g	382	31	with	with	IN
cord-265941-eff4le0g	382	32	L.	L.	NNP
cord-265941-eff4le0g	382	33	monocytogenes	monocytogenes	NNP
cord-265941-eff4le0g	382	34	[	[	-LRB-
cord-265941-eff4le0g	382	35	146	146	CD
cord-265941-eff4le0g	382	36	]	]	-RRB-
cord-265941-eff4le0g	382	37	,	,	,
cord-265941-eff4le0g	382	38	suggesting	suggest	VBG
cord-265941-eff4le0g	382	39	a	a	DT
cord-265941-eff4le0g	382	40	role	role	NN
cord-265941-eff4le0g	382	41	for	for	IN
cord-265941-eff4le0g	382	42	the	the	DT
cord-265941-eff4le0g	382	43	serine	serine	NN
cord-265941-eff4le0g	382	44	/	/	SYM
cord-265941-eff4le0g	382	45	threonine	threonine	NN
cord-265941-eff4le0g	382	46	kinase	kinase	NN
cord-265941-eff4le0g	382	47	activity	activity	NN
cord-265941-eff4le0g	382	48	of	of	IN
cord-265941-eff4le0g	382	49	RIPK2	ripk2	NN
cord-265941-eff4le0g	382	50	in	in	IN
cord-265941-eff4le0g	382	51	protection	protection	NN
cord-265941-eff4le0g	382	52	against	against	IN
cord-265941-eff4le0g	382	53	bacterial	bacterial	JJ
cord-265941-eff4le0g	382	54	infection	infection	NN
cord-265941-eff4le0g	382	55	.	.	.
cord-265941-eff4le0g	383	1	RIPK2	ripk2	XX
cord-265941-eff4le0g	384	1	signaling	signal	VBG
cord-265941-eff4le0g	384	2	may	may	MD
cord-265941-eff4le0g	384	3	also	also	RB
cord-265941-eff4le0g	384	4	be	be	VB
cord-265941-eff4le0g	384	5	regulated	regulate	VBN
cord-265941-eff4le0g	384	6	via	via	IN
cord-265941-eff4le0g	384	7	the	the	DT
cord-265941-eff4le0g	384	8	formation	formation	NN
cord-265941-eff4le0g	384	9	of	of	IN
cord-265941-eff4le0g	384	10	RIPosomes	riposome	NNS
cord-265941-eff4le0g	384	11	,	,	,
cord-265941-eff4le0g	384	12	which	which	WDT
cord-265941-eff4le0g	384	13	are	be	VBP
cord-265941-eff4le0g	384	14	high	high	JJ
cord-265941-eff4le0g	384	15	molecular	molecular	JJ
cord-265941-eff4le0g	384	16	weight	weight	NN
cord-265941-eff4le0g	384	17	cytoplasmic	cytoplasmic	JJ
cord-265941-eff4le0g	384	18	complexes	complex	NNS
cord-265941-eff4le0g	384	19	comprised	comprise	VBN
cord-265941-eff4le0g	384	20	of	of	IN
cord-265941-eff4le0g	384	21	RIPK2	ripk2	DT
cord-265941-eff4le0g	384	22	[	[	-LRB-
cord-265941-eff4le0g	384	23	199	199	CD
cord-265941-eff4le0g	384	24	,	,	,
cord-265941-eff4le0g	384	25	200	200	CD
cord-265941-eff4le0g	384	26	]	]	-RRB-
cord-265941-eff4le0g	384	27	.	.	.
cord-265941-eff4le0g	385	1	Ellwanger	Ellwanger	NNP
cord-265941-eff4le0g	385	2	et	et	NNP
cord-265941-eff4le0g	385	3	al	al	NNP
cord-265941-eff4le0g	385	4	.	.	.
cord-265941-eff4le0g	386	1	[	[	-LRB-
cord-265941-eff4le0g	386	2	199	199	CD
cord-265941-eff4le0g	386	3	]	]	-RRB-
cord-265941-eff4le0g	386	4	showed	show	VBD
cord-265941-eff4le0g	386	5	RIPosomes	riposome	NNS
cord-265941-eff4le0g	386	6	form	form	NN
cord-265941-eff4le0g	386	7	post	post	JJ
cord-265941-eff4le0g	386	8	-	-	JJ
cord-265941-eff4le0g	386	9	NF	nf	NN
cord-265941-eff4le0g	386	10	-	-	HYPH
cord-265941-eff4le0g	386	11	κB	κb	CD
cord-265941-eff4le0g	386	12	activation	activation	NN
cord-265941-eff4le0g	386	13	,	,	,
cord-265941-eff4le0g	386	14	and	and	CC
cord-265941-eff4le0g	386	15	suggest	suggest	VBP
cord-265941-eff4le0g	386	16	that	that	IN
cord-265941-eff4le0g	386	17	sequestration	sequestration	NN
cord-265941-eff4le0g	386	18	of	of	IN
cord-265941-eff4le0g	386	19	RIPK2	ripk2	NN
cord-265941-eff4le0g	386	20	in	in	IN
cord-265941-eff4le0g	386	21	these	these	DT
cord-265941-eff4le0g	386	22	complexes	complex	NNS
cord-265941-eff4le0g	386	23	may	may	MD
cord-265941-eff4le0g	386	24	act	act	VB
cord-265941-eff4le0g	386	25	to	to	TO
cord-265941-eff4le0g	386	26	dampen	dampen	VB
cord-265941-eff4le0g	386	27	RIPK2	ripk2	DT
cord-265941-eff4le0g	386	28	signaling	signaling	NN
cord-265941-eff4le0g	386	29	.	.	.
cord-265941-eff4le0g	387	1	Intriguingly	intriguingly	RB
cord-265941-eff4le0g	387	2	,	,	,
cord-265941-eff4le0g	387	3	RIPosomes	riposome	NNS
cord-265941-eff4le0g	387	4	form	form	VBP
cord-265941-eff4le0g	387	5	in	in	IN
cord-265941-eff4le0g	387	6	the	the	DT
cord-265941-eff4le0g	387	7	cytosol	cytosol	NN
cord-265941-eff4le0g	387	8	of	of	IN
cord-265941-eff4le0g	387	9	epithelial	epithelial	JJ
cord-265941-eff4le0g	387	10	cells	cell	NNS
cord-265941-eff4le0g	387	11	upon	upon	IN
cord-265941-eff4le0g	387	12	invasion	invasion	NN
cord-265941-eff4le0g	387	13	with	with	IN
cord-265941-eff4le0g	387	14	S.	S.	NNP
cord-265941-eff4le0g	387	15	flexneri	flexneri	NN
cord-265941-eff4le0g	387	16	,	,	,
cord-265941-eff4le0g	387	17	suggesting	suggest	VBG
cord-265941-eff4le0g	387	18	the	the	DT
cord-265941-eff4le0g	387	19	pathogen	pathogen	NN
cord-265941-eff4le0g	387	20	may	may	MD
cord-265941-eff4le0g	387	21	actively	actively	RB
cord-265941-eff4le0g	387	22	prevent	prevent	VB
cord-265941-eff4le0g	387	23	RIPK2	ripk2	XX
cord-265941-eff4le0g	387	24	signaling	signal	VBG
cord-265941-eff4le0g	387	25	via	via	IN
cord-265941-eff4le0g	387	26	an	an	DT
cord-265941-eff4le0g	387	27	unknown	unknown	JJ
cord-265941-eff4le0g	387	28	process	process	NN
cord-265941-eff4le0g	387	29	.	.	.
cord-265941-eff4le0g	388	1	Given	give	VBN
cord-265941-eff4le0g	388	2	that	that	DT
cord-265941-eff4le0g	388	3	inhibition	inhibition	NN
cord-265941-eff4le0g	388	4	of	of	IN
cord-265941-eff4le0g	388	5	XIAP	XIAP	NNP
cord-265941-eff4le0g	388	6	was	be	VBD
cord-265941-eff4le0g	388	7	shown	show	VBN
cord-265941-eff4le0g	388	8	to	to	TO
cord-265941-eff4le0g	388	9	promote	promote	VB
cord-265941-eff4le0g	388	10	deposition	deposition	NN
cord-265941-eff4le0g	388	11	of	of	IN
cord-265941-eff4le0g	388	12	RIPK2	ripk2	XX
cord-265941-eff4le0g	388	13	in	in	IN
cord-265941-eff4le0g	388	14	RIPosomes	riposome	NNS
cord-265941-eff4le0g	388	15	,	,	,
cord-265941-eff4le0g	388	16	it	-PRON-	PRP
cord-265941-eff4le0g	388	17	may	may	MD
cord-265941-eff4le0g	388	18	be	be	VB
cord-265941-eff4le0g	388	19	that	that	IN
cord-265941-eff4le0g	388	20	Shigella	Shigella	NNP
cord-265941-eff4le0g	388	21	encodes	encode	VBZ
cord-265941-eff4le0g	388	22	a	a	DT
cord-265941-eff4le0g	388	23	virulence	virulence	NN
cord-265941-eff4le0g	388	24	factor	factor	NN
cord-265941-eff4le0g	388	25	that	that	WDT
cord-265941-eff4le0g	388	26	targets	target	VBZ
cord-265941-eff4le0g	388	27	XIAP	xiap	NN
cord-265941-eff4le0g	388	28	for	for	IN
cord-265941-eff4le0g	388	29	cleavage	cleavage	NN
cord-265941-eff4le0g	388	30	or	or	CC
cord-265941-eff4le0g	388	31	degradation	degradation	NN
cord-265941-eff4le0g	388	32	,	,	,
cord-265941-eff4le0g	388	33	or	or	CC
cord-265941-eff4le0g	388	34	actively	actively	RB
cord-265941-eff4le0g	388	35	inhibits	inhibit	VBZ
cord-265941-eff4le0g	388	36	XIAP	xiap	NN
cord-265941-eff4le0g	388	37	-	-	HYPH
cord-265941-eff4le0g	388	38	designated	designate	VBN
cord-265941-eff4le0g	388	39	sites	site	NNS
cord-265941-eff4le0g	388	40	of	of	IN
cord-265941-eff4le0g	388	41	ubiquitylation	ubiquitylation	NN
cord-265941-eff4le0g	388	42	on	on	IN
cord-265941-eff4le0g	388	43	RIPK2	ripk2	XX
cord-265941-eff4le0g	388	44	to	to	TO
cord-265941-eff4le0g	388	45	inhibit	inhibit	VB
cord-265941-eff4le0g	388	46	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	388	47	signaling	signal	VBG
cord-265941-eff4le0g	388	48	[	[	-LRB-
cord-265941-eff4le0g	388	49	199	199	CD
cord-265941-eff4le0g	388	50	]	]	-RRB-
cord-265941-eff4le0g	388	51	.	.	.
cord-265941-eff4le0g	389	1	It	-PRON-	PRP
cord-265941-eff4le0g	389	2	is	be	VBZ
cord-265941-eff4le0g	389	3	now	now	RB
cord-265941-eff4le0g	389	4	established	establish	VBN
cord-265941-eff4le0g	389	5	that	that	IN
cord-265941-eff4le0g	389	6	NOD1	NOD1	NNP
cord-265941-eff4le0g	389	7	and	and	CC
cord-265941-eff4le0g	389	8	NOD2	NOD2	NNPS
cord-265941-eff4le0g	389	9	respond	respond	VBP
cord-265941-eff4le0g	389	10	to	to	IN
cord-265941-eff4le0g	389	11	viral	viral	JJ
cord-265941-eff4le0g	389	12	infections	infection	NNS
cord-265941-eff4le0g	389	13	,	,	,
cord-265941-eff4le0g	389	14	thus	thus	RB
cord-265941-eff4le0g	389	15	participating	participate	VBG
cord-265941-eff4le0g	389	16	in	in	IN
cord-265941-eff4le0g	389	17	the	the	DT
cord-265941-eff4le0g	389	18	coordinated	coordinated	JJ
cord-265941-eff4le0g	389	19	host	host	NN
cord-265941-eff4le0g	389	20	defense	defense	NN
cord-265941-eff4le0g	389	21	against	against	IN
cord-265941-eff4le0g	389	22	viruses	virus	NNS
cord-265941-eff4le0g	389	23	[	[	-LRB-
cord-265941-eff4le0g	389	24	201	201	CD
cord-265941-eff4le0g	389	25	]	]	-RRB-
cord-265941-eff4le0g	389	26	[	[	-LRB-
cord-265941-eff4le0g	389	27	202	202	CD
cord-265941-eff4le0g	389	28	]	]	-RRB-
cord-265941-eff4le0g	389	29	[	[	-LRB-
cord-265941-eff4le0g	389	30	203	203	CD
cord-265941-eff4le0g	389	31	]	]	-RRB-
cord-265941-eff4le0g	389	32	[	[	-LRB-
cord-265941-eff4le0g	389	33	204	204	CD
cord-265941-eff4le0g	389	34	]	]	-RRB-
cord-265941-eff4le0g	389	35	.	.	.
cord-265941-eff4le0g	390	1	Activation	activation	NN
cord-265941-eff4le0g	390	2	of	of	IN
cord-265941-eff4le0g	390	3	NOD1	NOD1	NNP
cord-265941-eff4le0g	390	4	,	,	,
cord-265941-eff4le0g	390	5	NOD2	NOD2	NNPS
cord-265941-eff4le0g	390	6	and	and	CC
cord-265941-eff4le0g	390	7	RIPK2	ripk2	XX
cord-265941-eff4le0g	390	8	during	during	IN
cord-265941-eff4le0g	390	9	viral	viral	JJ
cord-265941-eff4le0g	390	10	infection	infection	NN
cord-265941-eff4le0g	390	11	depends	depend	VBZ
cord-265941-eff4le0g	390	12	on	on	IN
cord-265941-eff4le0g	390	13	type	type	NN
cord-265941-eff4le0g	390	14	I	-PRON-	PRP
cord-265941-eff4le0g	390	15	IFN	IFN	NNP
cord-265941-eff4le0g	390	16	,	,	,
cord-265941-eff4le0g	390	17	synthesized	synthesize	VBN
cord-265941-eff4le0g	390	18	as	as	IN
cord-265941-eff4le0g	390	19	a	a	DT
cord-265941-eff4le0g	390	20	result	result	NN
cord-265941-eff4le0g	390	21	of	of	IN
cord-265941-eff4le0g	390	22	activation	activation	NN
cord-265941-eff4le0g	390	23	of	of	IN
cord-265941-eff4le0g	390	24	other	other	JJ
cord-265941-eff4le0g	390	25	PRRs	prr	NNS
cord-265941-eff4le0g	390	26	.	.	.
cord-265941-eff4le0g	391	1	One	one	CD
cord-265941-eff4le0g	391	2	of	of	IN
cord-265941-eff4le0g	391	3	the	the	DT
cord-265941-eff4le0g	391	4	first	first	JJ
cord-265941-eff4le0g	391	5	studies	study	NNS
cord-265941-eff4le0g	391	6	to	to	TO
cord-265941-eff4le0g	391	7	assess	assess	VB
cord-265941-eff4le0g	391	8	the	the	DT
cord-265941-eff4le0g	391	9	role	role	NN
cord-265941-eff4le0g	391	10	of	of	IN
cord-265941-eff4le0g	391	11	NOD2	NOD2	NNP
cord-265941-eff4le0g	391	12	/	/	SYM
cord-265941-eff4le0g	391	13	RIPK2	ripk2	CD
cord-265941-eff4le0g	391	14	activation	activation	NN
cord-265941-eff4le0g	391	15	in	in	IN
cord-265941-eff4le0g	391	16	viral	viral	JJ
cord-265941-eff4le0g	391	17	infection	infection	NN
cord-265941-eff4le0g	391	18	showed	show	VBD
cord-265941-eff4le0g	391	19	that	that	IN
cord-265941-eff4le0g	391	20	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	391	21	was	be	VBD
cord-265941-eff4le0g	391	22	critical	critical	JJ
cord-265941-eff4le0g	391	23	for	for	IN
cord-265941-eff4le0g	391	24	dampening	dampen	VBG
cord-265941-eff4le0g	391	25	inflammasome	inflammasome	NN
cord-265941-eff4le0g	391	26	activation	activation	NN
cord-265941-eff4le0g	391	27	during	during	IN
cord-265941-eff4le0g	391	28	H1N1	H1N1	NNP
cord-265941-eff4le0g	391	29	IAV	IAV	NNP
cord-265941-eff4le0g	391	30	infection	infection	NN
cord-265941-eff4le0g	391	31	[	[	-LRB-
cord-265941-eff4le0g	391	32	205	205	CD
cord-265941-eff4le0g	391	33	]	]	-RRB-
cord-265941-eff4le0g	391	34	.	.	.
cord-265941-eff4le0g	392	1	Here	here	RB
cord-265941-eff4le0g	392	2	,	,	,
cord-265941-eff4le0g	392	3	Ripk2	Ripk2	NNP
cord-265941-eff4le0g	392	4	−	−	NNP
cord-265941-eff4le0g	392	5	/−	/−	.
cord-265941-eff4le0g	392	6	mice	mouse	NNS
cord-265941-eff4le0g	392	7	were	be	VBD
cord-265941-eff4le0g	392	8	highly	highly	RB
cord-265941-eff4le0g	392	9	susceptible	susceptible	JJ
cord-265941-eff4le0g	392	10	IAV	IAV	NNP
cord-265941-eff4le0g	392	11	infection	infection	NN
cord-265941-eff4le0g	392	12	,	,	,
cord-265941-eff4le0g	392	13	whereby	whereby	WRB
cord-265941-eff4le0g	392	14	enhanced	enhance	VBN
cord-265941-eff4le0g	392	15	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	392	16	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	392	17	activation	activation	NN
cord-265941-eff4le0g	392	18	and	and	CC
cord-265941-eff4le0g	392	19	increased	increase	VBN
cord-265941-eff4le0g	392	20	IL-18	IL-18	NNP
cord-265941-eff4le0g	392	21	secretion	secretion	NN
cord-265941-eff4le0g	392	22	were	be	VBD
cord-265941-eff4le0g	392	23	potent	potent	JJ
cord-265941-eff4le0g	392	24	drivers	driver	NNS
cord-265941-eff4le0g	392	25	of	of	IN
cord-265941-eff4le0g	392	26	disease	disease	NN
cord-265941-eff4le0g	392	27	progression	progression	NN
cord-265941-eff4le0g	392	28	and	and	CC
cord-265941-eff4le0g	392	29	mortality	mortality	NN
cord-265941-eff4le0g	392	30	in	in	IN
cord-265941-eff4le0g	392	31	vivo	vivo	NNP
cord-265941-eff4le0g	392	32	.	.	.
cord-265941-eff4le0g	393	1	Negative	negative	JJ
cord-265941-eff4le0g	393	2	regulation	regulation	NN
cord-265941-eff4le0g	393	3	of	of	IN
cord-265941-eff4le0g	393	4	inflammasome	inflammasome	NN
cord-265941-eff4le0g	393	5	activity	activity	NN
cord-265941-eff4le0g	393	6	by	by	IN
cord-265941-eff4le0g	393	7	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	393	8	is	be	VBZ
cord-265941-eff4le0g	393	9	dependent	dependent	JJ
cord-265941-eff4le0g	393	10	its	-PRON-	PRP$
cord-265941-eff4le0g	393	11	kinase	kinase	NN
cord-265941-eff4le0g	393	12	-	-	HYPH
cord-265941-eff4le0g	393	13	mediated	mediate	VBN
cord-265941-eff4le0g	393	14	activation	activation	NN
cord-265941-eff4le0g	393	15	of	of	IN
cord-265941-eff4le0g	393	16	the	the	DT
cord-265941-eff4le0g	393	17	mitophagy	mitophagy	NN
cord-265941-eff4le0g	393	18	inducer	inducer	NN
cord-265941-eff4le0g	393	19	,	,	,
cord-265941-eff4le0g	393	20	ULK1	ULK1	NNP
cord-265941-eff4le0g	393	21	.	.	.
cord-265941-eff4le0g	394	1	Thus	thus	RB
cord-265941-eff4le0g	394	2	NOD2	NOD2	NNPS
cord-265941-eff4le0g	394	3	and	and	CC
cord-265941-eff4le0g	394	4	RIPK2	ripk2	XX
cord-265941-eff4le0g	394	5	respond	respond	VBP
cord-265941-eff4le0g	394	6	to	to	IN
cord-265941-eff4le0g	394	7	IAV	IAV	NNP
cord-265941-eff4le0g	394	8	infection	infection	NN
cord-265941-eff4le0g	394	9	by	by	IN
cord-265941-eff4le0g	394	10	promoting	promote	VBG
cord-265941-eff4le0g	394	11	ULK1	ulk1	JJ
cord-265941-eff4le0g	394	12	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	394	13	and	and	CC
cord-265941-eff4le0g	394	14	inducing	induce	VBG
cord-265941-eff4le0g	394	15	mitophagy	mitophagy	NN
cord-265941-eff4le0g	394	16	,	,	,
cord-265941-eff4le0g	394	17	which	which	WDT
cord-265941-eff4le0g	394	18	dampens	dampen	VBZ
cord-265941-eff4le0g	394	19	inflammasome	inflammasome	NN
cord-265941-eff4le0g	394	20	activation	activation	NN
cord-265941-eff4le0g	394	21	and	and	CC
cord-265941-eff4le0g	394	22	IL-18	IL-18	NNP
cord-265941-eff4le0g	394	23	production	production	NN
cord-265941-eff4le0g	394	24	.	.	.
cord-265941-eff4le0g	395	1	In	in	IN
cord-265941-eff4le0g	395	2	addition	addition	NN
cord-265941-eff4le0g	395	3	,	,	,
cord-265941-eff4le0g	395	4	both	both	DT
cord-265941-eff4le0g	395	5	NK	NK	NNP
cord-265941-eff4le0g	395	6	cells	cell	NNS
cord-265941-eff4le0g	395	7	and	and	CC
cord-265941-eff4le0g	395	8	CD8	CD8	NNP
cord-265941-eff4le0g	395	9	+	+	CC
cord-265941-eff4le0g	395	10	T	T	NNP
cord-265941-eff4le0g	395	11	cells	cell	NNS
cord-265941-eff4le0g	395	12	isolated	isolate	VBN
cord-265941-eff4le0g	395	13	from	from	IN
cord-265941-eff4le0g	395	14	IAV	IAV	NNP
cord-265941-eff4le0g	395	15	-	-	HYPH
cord-265941-eff4le0g	395	16	infected	infect	VBN
cord-265941-eff4le0g	396	1	Ripk2	Ripk2	NNP
cord-265941-eff4le0g	396	2	-/mice	-/mice	NNP
cord-265941-eff4le0g	396	3	are	be	VBP
cord-265941-eff4le0g	396	4	highly	highly	RB
cord-265941-eff4le0g	396	5	activated	activate	VBN
cord-265941-eff4le0g	396	6	and	and	CC
cord-265941-eff4le0g	396	7	exhibit	exhibit	NN
cord-265941-eff4le0g	396	8	increased	increase	VBD
cord-265941-eff4le0g	396	9	IFN	IFN	NNP
cord-265941-eff4le0g	396	10	-	-	HYPH
cord-265941-eff4le0g	396	11	γ	γ	NN
cord-265941-eff4le0g	396	12	production	production	NN
cord-265941-eff4le0g	396	13	despite	despite	IN
cord-265941-eff4le0g	396	14	the	the	DT
cord-265941-eff4le0g	396	15	total	total	JJ
cord-265941-eff4le0g	396	16	numbers	number	NNS
cord-265941-eff4le0g	396	17	of	of	IN
cord-265941-eff4le0g	396	18	these	these	DT
cord-265941-eff4le0g	396	19	cells	cell	NNS
cord-265941-eff4le0g	396	20	being	be	VBG
cord-265941-eff4le0g	396	21	similar	similar	JJ
cord-265941-eff4le0g	396	22	in	in	IN
cord-265941-eff4le0g	396	23	WT	WT	NNP
cord-265941-eff4le0g	396	24	mice	mouse	NNS
cord-265941-eff4le0g	396	25	.	.	.
cord-265941-eff4le0g	397	1	These	these	DT
cord-265941-eff4le0g	397	2	results	result	NNS
cord-265941-eff4le0g	397	3	indicate	indicate	VBP
cord-265941-eff4le0g	397	4	that	that	IN
cord-265941-eff4le0g	397	5	increased	increase	VBN
cord-265941-eff4le0g	397	6	IL-18	IL-18	NNP
cord-265941-eff4le0g	397	7	in	in	IN
cord-265941-eff4le0g	397	8	Ripk2	Ripk2	NNP
cord-265941-eff4le0g	397	9	-/mice	-/mice	XX
cord-265941-eff4le0g	397	10	subsequently	subsequently	RB
cord-265941-eff4le0g	397	11	leads	lead	VBZ
cord-265941-eff4le0g	397	12	to	to	IN
cord-265941-eff4le0g	397	13	increased	increase	VBN
cord-265941-eff4le0g	397	14	IFN	IFN	NNP
cord-265941-eff4le0g	397	15	-	-	HYPH
cord-265941-eff4le0g	397	16	γ	γ	NN
cord-265941-eff4le0g	397	17	production	production	NN
cord-265941-eff4le0g	397	18	from	from	IN
cord-265941-eff4le0g	397	19	innate	innate	JJ
cord-265941-eff4le0g	397	20	and	and	CC
cord-265941-eff4le0g	397	21	adaptive	adaptive	JJ
cord-265941-eff4le0g	397	22	cell	cell	NN
cord-265941-eff4le0g	397	23	populations	population	NNS
cord-265941-eff4le0g	397	24	[	[	-LRB-
cord-265941-eff4le0g	397	25	205	205	CD
cord-265941-eff4le0g	397	26	]	]	-RRB-
cord-265941-eff4le0g	397	27	.	.	.
cord-265941-eff4le0g	398	1	Hepatitis	Hepatitis	NNP
cord-265941-eff4le0g	398	2	B	B	NNP
cord-265941-eff4le0g	398	3	and	and	CC
cord-265941-eff4le0g	398	4	C	C	NNP
cord-265941-eff4le0g	398	5	virus	virus	NN
cord-265941-eff4le0g	398	6	(	(	-LRB-
cord-265941-eff4le0g	398	7	HBV	HBV	NNP
cord-265941-eff4le0g	398	8	and	and	CC
cord-265941-eff4le0g	398	9	HCV	HCV	NNP
cord-265941-eff4le0g	398	10	)	)	-RRB-
cord-265941-eff4le0g	398	11	are	be	VBP
cord-265941-eff4le0g	398	12	associated	associate	VBN
cord-265941-eff4le0g	398	13	with	with	IN
cord-265941-eff4le0g	398	14	the	the	DT
cord-265941-eff4le0g	398	15	development	development	NN
cord-265941-eff4le0g	398	16	of	of	IN
cord-265941-eff4le0g	398	17	hepatocellular	hepatocellular	JJ
cord-265941-eff4le0g	398	18	carcinoma	carcinoma	NN
cord-265941-eff4le0g	398	19	[	[	-LRB-
cord-265941-eff4le0g	398	20	206	206	CD
cord-265941-eff4le0g	398	21	]	]	-RRB-
cord-265941-eff4le0g	398	22	.	.	.
cord-265941-eff4le0g	399	1	NOD1/	NOD1/	NNP
cord-265941-eff4le0g	400	1	RIPK2	ripk2	DT
cord-265941-eff4le0g	400	2	signaling	signaling	NN
cord-265941-eff4le0g	400	3	is	be	VBZ
cord-265941-eff4le0g	400	4	activated	activate	VBN
cord-265941-eff4le0g	400	5	by	by	IN
cord-265941-eff4le0g	400	6	the	the	DT
cord-265941-eff4le0g	400	7	viral	viral	JJ
cord-265941-eff4le0g	400	8	polymerase	polymerase	NN
cord-265941-eff4le0g	400	9	NS5B	NS5B	''
cord-265941-eff4le0g	400	10	of	of	IN
cord-265941-eff4le0g	400	11	HCV	HCV	NNP
cord-265941-eff4le0g	400	12	[	[	-LRB-
cord-265941-eff4le0g	400	13	207	207	CD
cord-265941-eff4le0g	400	14	]	]	-RRB-
cord-265941-eff4le0g	400	15	,	,	,
cord-265941-eff4le0g	400	16	thus	thus	RB
cord-265941-eff4le0g	400	17	deletion	deletion	NN
cord-265941-eff4le0g	400	18	of	of	IN
cord-265941-eff4le0g	400	19	RIPK2	ripk2	NN
cord-265941-eff4le0g	400	20	in	in	IN
cord-265941-eff4le0g	400	21	HepaRG	HepaRG	NNP
cord-265941-eff4le0g	400	22	cells	cell	NNS
cord-265941-eff4le0g	400	23	expressing	express	VBG
cord-265941-eff4le0g	400	24	NS5B	NS5B	NNP
cord-265941-eff4le0g	400	25	,	,	,
cord-265941-eff4le0g	400	26	results	result	NNS
cord-265941-eff4le0g	400	27	in	in	IN
cord-265941-eff4le0g	400	28	significantly	significantly	RB
cord-265941-eff4le0g	400	29	reduced	reduce	VBN
cord-265941-eff4le0g	400	30	MAPK	MAPK	NNP
cord-265941-eff4le0g	400	31	activation	activation	NN
cord-265941-eff4le0g	400	32	,	,	,
cord-265941-eff4le0g	400	33	proinflammatory	proinflammatory	JJ
cord-265941-eff4le0g	400	34	cytokine	cytokine	NN
cord-265941-eff4le0g	400	35	production	production	NN
cord-265941-eff4le0g	400	36	,	,	,
cord-265941-eff4le0g	400	37	and	and	CC
cord-265941-eff4le0g	400	38	IFNβ	IFNβ	NNS
cord-265941-eff4le0g	400	39	production	production	NN
cord-265941-eff4le0g	400	40	.	.	.
cord-265941-eff4le0g	401	1	In	in	IN
cord-265941-eff4le0g	401	2	HBV	HBV	NNP
cord-265941-eff4le0g	401	3	infection	infection	NN
cord-265941-eff4le0g	401	4	,	,	,
cord-265941-eff4le0g	401	5	the	the	DT
cord-265941-eff4le0g	401	6	Hepatitis	Hepatitis	NNP
cord-265941-eff4le0g	401	7	B	B	NNP
cord-265941-eff4le0g	401	8	e	e	NN
cord-265941-eff4le0g	401	9	-	-	NN
cord-265941-eff4le0g	401	10	antigen	antigen	NN
cord-265941-eff4le0g	401	11	(	(	-LRB-
cord-265941-eff4le0g	401	12	HBeAg	hbeag	CD
cord-265941-eff4le0g	401	13	)	)	-RRB-
cord-265941-eff4le0g	401	14	inhibits	inhibit	VBZ
cord-265941-eff4le0g	401	15	RIPK2	ripk2	DT
cord-265941-eff4le0g	401	16	expression	expression	NN
cord-265941-eff4le0g	401	17	and	and	CC
cord-265941-eff4le0g	401	18	also	also	RB
cord-265941-eff4le0g	401	19	interacts	interact	VBZ
cord-265941-eff4le0g	401	20	with	with	IN
cord-265941-eff4le0g	401	21	RIPK2	ripk2	XX
cord-265941-eff4le0g	401	22	in	in	IN
cord-265941-eff4le0g	401	23	HepG2	HepG2	NNP
cord-265941-eff4le0g	401	24	cells	cell	NNS
cord-265941-eff4le0g	401	25	in	in	IN
cord-265941-eff4le0g	401	26	vitro	vitro	FW
cord-265941-eff4le0g	401	27	,	,	,
cord-265941-eff4le0g	401	28	resulting	result	VBG
cord-265941-eff4le0g	401	29	in	in	IN
cord-265941-eff4le0g	401	30	inhibition	inhibition	NN
cord-265941-eff4le0g	401	31	of	of	IN
cord-265941-eff4le0g	401	32	NOD1	NOD1	NNP
cord-265941-eff4le0g	401	33	/	/	SYM
cord-265941-eff4le0g	401	34	RIPK2-mediated	ripk2-mediated	JJ
cord-265941-eff4le0g	401	35	NF	NF	NNP
cord-265941-eff4le0g	401	36	-	-	HYPH
cord-265941-eff4le0g	401	37	κB	κb	CD
cord-265941-eff4le0g	401	38	activation	activation	NN
cord-265941-eff4le0g	401	39	and	and	CC
cord-265941-eff4le0g	401	40	subsequent	subsequent	JJ
cord-265941-eff4le0g	401	41	IL-6	IL-6	NNP
cord-265941-eff4le0g	401	42	production	production	NN
cord-265941-eff4le0g	401	43	[	[	-LRB-
cord-265941-eff4le0g	401	44	208	208	CD
cord-265941-eff4le0g	401	45	]	]	-RRB-
cord-265941-eff4le0g	401	46	.	.	.
cord-265941-eff4le0g	402	1	These	these	DT
cord-265941-eff4le0g	402	2	studies	study	NNS
cord-265941-eff4le0g	402	3	highlight	highlight	VBP
cord-265941-eff4le0g	402	4	the	the	DT
cord-265941-eff4le0g	402	5	importance	importance	NN
cord-265941-eff4le0g	402	6	of	of	IN
cord-265941-eff4le0g	402	7	RIPK2	ripk2	XX
cord-265941-eff4le0g	402	8	in	in	IN
cord-265941-eff4le0g	402	9	controlling	control	VBG
cord-265941-eff4le0g	402	10	chronic	chronic	JJ
cord-265941-eff4le0g	402	11	Hepatitis	Hepatitis	NNP
cord-265941-eff4le0g	402	12	infections	infection	NNS
cord-265941-eff4le0g	402	13	.	.	.
cord-265941-eff4le0g	403	1	To	to	IN
cord-265941-eff4le0g	403	2	date	date	NN
cord-265941-eff4le0g	403	3	,	,	,
cord-265941-eff4le0g	403	4	the	the	DT
cord-265941-eff4le0g	403	5	only	only	RB
cord-265941-eff4le0g	403	6	known	know	VBN
cord-265941-eff4le0g	403	7	pathogens	pathogen	NNS
cord-265941-eff4le0g	403	8	to	to	TO
cord-265941-eff4le0g	403	9	directly	directly	RB
cord-265941-eff4le0g	403	10	target	target	VB
cord-265941-eff4le0g	403	11	RIPK2	ripk2	XX
cord-265941-eff4le0g	403	12	during	during	IN
cord-265941-eff4le0g	403	13	infection	infection	NN
cord-265941-eff4le0g	403	14	are	be	VBP
cord-265941-eff4le0g	403	15	HIV-1	HIV-1	NNP
cord-265941-eff4le0g	403	16	and	and	CC
cord-265941-eff4le0g	403	17	the	the	DT
cord-265941-eff4le0g	403	18	primary	primary	JJ
cord-265941-eff4le0g	403	19	etiologic	etiologic	JJ
cord-265941-eff4le0g	403	20	agent	agent	NN
cord-265941-eff4le0g	403	21	of	of	IN
cord-265941-eff4le0g	403	22	periodontal	periodontal	JJ
cord-265941-eff4le0g	403	23	disease	disease	NN
cord-265941-eff4le0g	403	24	,	,	,
cord-265941-eff4le0g	403	25	Porphyromonas	Porphyromonas	NNP
cord-265941-eff4le0g	403	26	gingivalis	gingivalis	NNP
cord-265941-eff4le0g	403	27	.	.	.
cord-265941-eff4le0g	404	1	The	the	DT
cord-265941-eff4le0g	404	2	HIV-1	HIV-1	NNP
cord-265941-eff4le0g	404	3	protease	protease	NN
cord-265941-eff4le0g	404	4	PR	PR	NNP
cord-265941-eff4le0g	404	5	cleaves	cleave	VBZ
cord-265941-eff4le0g	404	6	RIPK2	ripk2	XX
cord-265941-eff4le0g	404	7	within	within	IN
cord-265941-eff4le0g	404	8	the	the	DT
cord-265941-eff4le0g	404	9	N	N	NNP
cord-265941-eff4le0g	404	10	-	-	HYPH
cord-265941-eff4le0g	404	11	terminus	terminus	NN
cord-265941-eff4le0g	404	12	,	,	,
cord-265941-eff4le0g	404	13	although	although	IN
cord-265941-eff4le0g	404	14	its	-PRON-	PRP$
cord-265941-eff4le0g	404	15	outcomes	outcome	NNS
cord-265941-eff4le0g	404	16	in	in	IN
cord-265941-eff4le0g	404	17	infection	infection	NN
cord-265941-eff4le0g	404	18	have	have	VBP
cord-265941-eff4le0g	404	19	not	not	RB
cord-265941-eff4le0g	404	20	been	be	VBN
cord-265941-eff4le0g	404	21	tested	test	VBN
cord-265941-eff4le0g	404	22	[	[	-LRB-
cord-265941-eff4le0g	404	23	102	102	CD
cord-265941-eff4le0g	404	24	]	]	-RRB-
cord-265941-eff4le0g	404	25	.	.	.
cord-265941-eff4le0g	405	1	Similarly	similarly	RB
cord-265941-eff4le0g	405	2	,	,	,
cord-265941-eff4le0g	405	3	P.	P.	NNP
cord-265941-eff4le0g	405	4	gingivalis	gingivalis	NNP
cord-265941-eff4le0g	405	5	infection	infection	NN
cord-265941-eff4le0g	405	6	of	of	IN
cord-265941-eff4le0g	405	7	human	human	JJ
cord-265941-eff4le0g	405	8	aortic	aortic	JJ
cord-265941-eff4le0g	405	9	endothelial	endothelial	JJ
cord-265941-eff4le0g	405	10	cells	cell	NNS
cord-265941-eff4le0g	405	11	results	result	NNS
cord-265941-eff4le0g	405	12	in	in	IN
cord-265941-eff4le0g	405	13	rapid	rapid	JJ
cord-265941-eff4le0g	405	14	direct	direct	JJ
cord-265941-eff4le0g	405	15	cleavage	cleavage	NN
cord-265941-eff4le0g	405	16	of	of	IN
cord-265941-eff4le0g	405	17	RIPK2	ripk2	NN
cord-265941-eff4le0g	405	18	,	,	,
cord-265941-eff4le0g	405	19	and	and	CC
cord-265941-eff4le0g	405	20	is	be	VBZ
cord-265941-eff4le0g	405	21	dependent	dependent	JJ
cord-265941-eff4le0g	405	22	upon	upon	IN
cord-265941-eff4le0g	405	23	the	the	DT
cord-265941-eff4le0g	405	24	lysine	lysine	NN
cord-265941-eff4le0g	405	25	-	-	HYPH
cord-265941-eff4le0g	405	26	specific	specific	JJ
cord-265941-eff4le0g	405	27	protease	protease	NN
cord-265941-eff4le0g	405	28	,	,	,
cord-265941-eff4le0g	405	29	gingipain	gingipain	NNP
cord-265941-eff4le0g	405	30	(	(	-LRB-
cord-265941-eff4le0g	405	31	Kgp	Kgp	NNP
cord-265941-eff4le0g	405	32	)	)	-RRB-
cord-265941-eff4le0g	405	33	[	[	-LRB-
cord-265941-eff4le0g	405	34	209	209	CD
cord-265941-eff4le0g	405	35	]	]	-RRB-
cord-265941-eff4le0g	405	36	.	.	.
cord-265941-eff4le0g	406	1	Given	give	VBN
cord-265941-eff4le0g	406	2	the	the	DT
cord-265941-eff4le0g	406	3	mounting	mount	VBG
cord-265941-eff4le0g	406	4	evidence	evidence	NN
cord-265941-eff4le0g	406	5	for	for	IN
cord-265941-eff4le0g	406	6	pathogens	pathogen	NNS
cord-265941-eff4le0g	406	7	targeting	target	VBG
cord-265941-eff4le0g	406	8	RIP	rip	NN
cord-265941-eff4le0g	406	9	kinases	kinase	NNS
cord-265941-eff4le0g	406	10	,	,	,
cord-265941-eff4le0g	406	11	it	-PRON-	PRP
cord-265941-eff4le0g	406	12	would	would	MD
cord-265941-eff4le0g	406	13	not	not	RB
cord-265941-eff4le0g	406	14	be	be	VB
cord-265941-eff4le0g	406	15	surprising	surprising	JJ
cord-265941-eff4le0g	406	16	if	if	IN
cord-265941-eff4le0g	406	17	other	other	JJ
cord-265941-eff4le0g	406	18	pathogens	pathogen	NNS
cord-265941-eff4le0g	406	19	were	be	VBD
cord-265941-eff4le0g	406	20	found	find	VBN
cord-265941-eff4le0g	406	21	to	to	TO
cord-265941-eff4le0g	406	22	specifically	specifically	RB
cord-265941-eff4le0g	406	23	inactivate	inactivate	VB
cord-265941-eff4le0g	406	24	RIPK2	ripk2	XX
cord-265941-eff4le0g	406	25	in	in	IN
cord-265941-eff4le0g	406	26	future	future	JJ
cord-265941-eff4le0g	406	27	studies	study	NNS
cord-265941-eff4le0g	406	28	.	.	.
cord-265941-eff4le0g	407	1	There	there	EX
cord-265941-eff4le0g	407	2	is	be	VBZ
cord-265941-eff4le0g	407	3	currently	currently	RB
cord-265941-eff4le0g	407	4	relatively	relatively	RB
cord-265941-eff4le0g	407	5	little	little	JJ
cord-265941-eff4le0g	407	6	published	publish	VBN
cord-265941-eff4le0g	407	7	on	on	IN
cord-265941-eff4le0g	407	8	RIPK4	RIPK4	NNP
cord-265941-eff4le0g	407	9	-	-	SYM
cord-265941-eff4le0g	407	10	6	6	CD
cord-265941-eff4le0g	407	11	and	and	CC
cord-265941-eff4le0g	407	12	their	-PRON-	PRP$
cord-265941-eff4le0g	407	13	role	role	NN
cord-265941-eff4le0g	407	14	in	in	IN
cord-265941-eff4le0g	407	15	host	host	NN
cord-265941-eff4le0g	407	16	responses	response	NNS
cord-265941-eff4le0g	407	17	to	to	IN
cord-265941-eff4le0g	407	18	pathogen	pathogen	NN
cord-265941-eff4le0g	407	19	infection	infection	NN
cord-265941-eff4le0g	407	20	,	,	,
cord-265941-eff4le0g	407	21	however	however	RB
cord-265941-eff4le0g	407	22	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	407	23	is	be	VBZ
cord-265941-eff4le0g	407	24	emerging	emerge	VBG
cord-265941-eff4le0g	407	25	as	as	IN
cord-265941-eff4le0g	407	26	an	an	DT
cord-265941-eff4le0g	407	27	important	important	JJ
cord-265941-eff4le0g	407	28	mediator	mediator	NN
cord-265941-eff4le0g	407	29	of	of	IN
cord-265941-eff4le0g	407	30	immunity	immunity	NN
cord-265941-eff4le0g	407	31	to	to	IN
cord-265941-eff4le0g	407	32	intracellular	intracellular	JJ
cord-265941-eff4le0g	407	33	pathogens	pathogen	NNS
cord-265941-eff4le0g	407	34	.	.	.
cord-265941-eff4le0g	408	1	RIPK4	RIPK4	NNP
cord-265941-eff4le0g	408	2	has	have	VBZ
cord-265941-eff4le0g	408	3	a	a	DT
cord-265941-eff4le0g	408	4	well	well	RB
cord-265941-eff4le0g	408	5	-	-	HYPH
cord-265941-eff4le0g	408	6	described	describe	VBN
cord-265941-eff4le0g	408	7	role	role	NN
cord-265941-eff4le0g	408	8	in	in	IN
cord-265941-eff4le0g	408	9	cellular	cellular	JJ
cord-265941-eff4le0g	408	10	differentiation	differentiation	NN
cord-265941-eff4le0g	408	11	,	,	,
cord-265941-eff4le0g	408	12	but	but	CC
cord-265941-eff4le0g	408	13	also	also	RB
cord-265941-eff4le0g	408	14	mediates	mediate	VBZ
cord-265941-eff4le0g	408	15	proinflammatory	proinflammatory	JJ
cord-265941-eff4le0g	408	16	cytokine	cytokine	NN
cord-265941-eff4le0g	408	17	production	production	NN
cord-265941-eff4le0g	408	18	in	in	IN
cord-265941-eff4le0g	408	19	keratinocytes	keratinocyte	NNS
cord-265941-eff4le0g	408	20	via	via	IN
cord-265941-eff4le0g	408	21	direct	direct	JJ
cord-265941-eff4le0g	408	22	stimulation	stimulation	NN
cord-265941-eff4le0g	408	23	of	of	IN
cord-265941-eff4le0g	408	24	IRF6	IRF6	NNP
cord-265941-eff4le0g	408	25	[	[	-LRB-
cord-265941-eff4le0g	408	26	210	210	CD
cord-265941-eff4le0g	408	27	]	]	-RRB-
cord-265941-eff4le0g	408	28	.	.	.
cord-265941-eff4le0g	409	1	Furthermore	furthermore	RB
cord-265941-eff4le0g	409	2	,	,	,
cord-265941-eff4le0g	409	3	overexpression	overexpression	NN
cord-265941-eff4le0g	409	4	of	of	IN
cord-265941-eff4le0g	409	5	RIPK4	ripk4	NN
cord-265941-eff4le0g	409	6	leads	lead	VBZ
cord-265941-eff4le0g	409	7	to	to	IN
cord-265941-eff4le0g	409	8	NF	nf	NN
cord-265941-eff4le0g	409	9	-	-	HYPH
cord-265941-eff4le0g	409	10	κB	κB	NNP
cord-265941-eff4le0g	409	11	and	and	CC
cord-265941-eff4le0g	409	12	MAPK	MAPK	NNP
cord-265941-eff4le0g	409	13	activation	activation	NN
cord-265941-eff4le0g	409	14	[	[	-LRB-
cord-265941-eff4le0g	409	15	211	211	CD
cord-265941-eff4le0g	409	16	]	]	-RRB-
cord-265941-eff4le0g	409	17	.	.	.
cord-265941-eff4le0g	410	1	Although	although	IN
cord-265941-eff4le0g	410	2	no	no	DT
cord-265941-eff4le0g	410	3	study	study	NN
cord-265941-eff4le0g	410	4	has	have	VBZ
cord-265941-eff4le0g	410	5	reported	report	VBN
cord-265941-eff4le0g	410	6	a	a	DT
cord-265941-eff4le0g	410	7	direct	direct	JJ
cord-265941-eff4le0g	410	8	role	role	NN
cord-265941-eff4le0g	410	9	for	for	IN
cord-265941-eff4le0g	410	10	RIPK4	RIPK4	NNP
cord-265941-eff4le0g	410	11	in	in	IN
cord-265941-eff4le0g	410	12	host	host	NN
cord-265941-eff4le0g	410	13	responses	response	NNS
cord-265941-eff4le0g	410	14	to	to	IN
cord-265941-eff4le0g	410	15	pathogens	pathogen	NNS
cord-265941-eff4le0g	410	16	,	,	,
cord-265941-eff4le0g	410	17	it	-PRON-	PRP
cord-265941-eff4le0g	410	18	would	would	MD
cord-265941-eff4le0g	410	19	not	not	RB
cord-265941-eff4le0g	410	20	be	be	VB
cord-265941-eff4le0g	410	21	surprising	surprising	JJ
cord-265941-eff4le0g	410	22	to	to	TO
cord-265941-eff4le0g	410	23	find	find	VB
cord-265941-eff4le0g	410	24	RIPK4	RIPK4	NNP
cord-265941-eff4le0g	410	25	mediates	mediate	VBZ
cord-265941-eff4le0g	410	26	inflammation	inflammation	NN
cord-265941-eff4le0g	410	27	during	during	IN
cord-265941-eff4le0g	410	28	infection	infection	NN
cord-265941-eff4le0g	410	29	.	.	.
cord-265941-eff4le0g	411	1	RIPK5	RIPK5	NNP
cord-265941-eff4le0g	412	1	on	on	IN
cord-265941-eff4le0g	412	2	the	the	DT
cord-265941-eff4le0g	412	3	other	other	JJ
cord-265941-eff4le0g	412	4	hand	hand	NN
cord-265941-eff4le0g	412	5	,	,	,
cord-265941-eff4le0g	412	6	has	have	VBZ
cord-265941-eff4le0g	412	7	no	no	DT
cord-265941-eff4le0g	412	8	reported	report	VBN
cord-265941-eff4le0g	412	9	association	association	NN
cord-265941-eff4le0g	412	10	with	with	IN
cord-265941-eff4le0g	412	11	innate	innate	JJ
cord-265941-eff4le0g	412	12	or	or	CC
cord-265941-eff4le0g	412	13	adaptive	adaptive	JJ
cord-265941-eff4le0g	412	14	immune	immune	JJ
cord-265941-eff4le0g	412	15	responses	response	NNS
cord-265941-eff4le0g	412	16	in	in	IN
cord-265941-eff4le0g	412	17	mammals	mammal	NNS
cord-265941-eff4le0g	412	18	.	.	.
cord-265941-eff4le0g	413	1	Pathogenic	pathogenic	JJ
cord-265941-eff4le0g	413	2	variants	variant	NNS
cord-265941-eff4le0g	413	3	of	of	IN
cord-265941-eff4le0g	413	4	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	413	5	are	be	VBP
cord-265941-eff4le0g	413	6	one	one	CD
cord-265941-eff4le0g	413	7	of	of	IN
cord-265941-eff4le0g	413	8	the	the	DT
cord-265941-eff4le0g	413	9	most	most	RBS
cord-265941-eff4le0g	413	10	prominent	prominent	JJ
cord-265941-eff4le0g	413	11	genetic	genetic	JJ
cord-265941-eff4le0g	413	12	causes	cause	NNS
cord-265941-eff4le0g	413	13	of	of	IN
cord-265941-eff4le0g	413	14	Parkinson	Parkinson	NNP
cord-265941-eff4le0g	413	15	disease	disease	NN
cord-265941-eff4le0g	413	16	(	(	-LRB-
cord-265941-eff4le0g	413	17	PD	PD	NNP
cord-265941-eff4le0g	413	18	)	)	-RRB-
cord-265941-eff4le0g	413	19	[	[	-LRB-
cord-265941-eff4le0g	413	20	212	212	CD
cord-265941-eff4le0g	413	21	]	]	-RRB-
cord-265941-eff4le0g	413	22	,	,	,
cord-265941-eff4le0g	413	23	whereas	whereas	IN
cord-265941-eff4le0g	413	24	RIPK6	ripk6	NN
cord-265941-eff4le0g	413	25	variants	variant	NNS
cord-265941-eff4le0g	413	26	have	have	VBP
cord-265941-eff4le0g	413	27	been	be	VBN
cord-265941-eff4le0g	413	28	shown	show	VBN
cord-265941-eff4le0g	413	29	to	to	TO
cord-265941-eff4le0g	413	30	have	have	VB
cord-265941-eff4le0g	413	31	no	no	DT
cord-265941-eff4le0g	413	32	association	association	NN
cord-265941-eff4le0g	413	33	with	with	IN
cord-265941-eff4le0g	413	34	the	the	DT
cord-265941-eff4le0g	413	35	development	development	NN
cord-265941-eff4le0g	413	36	of	of	IN
cord-265941-eff4le0g	413	37	PD	PD	NNP
cord-265941-eff4le0g	413	38	.	.	.
cord-265941-eff4le0g	414	1	As	as	IN
cord-265941-eff4le0g	414	2	for	for	IN
cord-265941-eff4le0g	414	3	infection	infection	NN
cord-265941-eff4le0g	414	4	,	,	,
cord-265941-eff4le0g	414	5	the	the	DT
cord-265941-eff4le0g	414	6	only	only	RB
cord-265941-eff4le0g	414	7	reported	report	VBN
cord-265941-eff4le0g	414	8	data	datum	NNS
cord-265941-eff4le0g	414	9	for	for	IN
cord-265941-eff4le0g	414	10	RIPK6	ripk6	NN
cord-265941-eff4le0g	414	11	is	be	VBZ
cord-265941-eff4le0g	414	12	in	in	IN
cord-265941-eff4le0g	414	13	relation	relation	NN
cord-265941-eff4le0g	414	14	to	to	IN
cord-265941-eff4le0g	414	15	bovine	bovine	JJ
cord-265941-eff4le0g	414	16	viral	viral	JJ
cord-265941-eff4le0g	414	17	diarrhoea	diarrhoea	NN
cord-265941-eff4le0g	414	18	virus	virus	NN
cord-265941-eff4le0g	414	19	(	(	-LRB-
cord-265941-eff4le0g	414	20	BVDV	BVDV	NNP
cord-265941-eff4le0g	414	21	)	)	-RRB-
cord-265941-eff4le0g	414	22	,	,	,
cord-265941-eff4le0g	414	23	where	where	WRB
cord-265941-eff4le0g	414	24	RIPK6	RIPK6	NNP
cord-265941-eff4le0g	414	25	is	be	VBZ
cord-265941-eff4le0g	414	26	downregulated	downregulate	VBN
cord-265941-eff4le0g	414	27	in	in	IN
cord-265941-eff4le0g	414	28	PBMCs	PBMCs	NNP
cord-265941-eff4le0g	414	29	infected	infect	VBN
cord-265941-eff4le0g	414	30	with	with	IN
cord-265941-eff4le0g	414	31	BVDV-2	BVDV-2	NNP
cord-265941-eff4le0g	414	32	[	[	-LRB-
cord-265941-eff4le0g	414	33	213	213	CD
cord-265941-eff4le0g	414	34	]	]	-RRB-
cord-265941-eff4le0g	414	35	.	.	.
cord-265941-eff4le0g	415	1	RIPK7	RIPK7	VBN
cord-265941-eff4le0g	415	2	however	however	RB
cord-265941-eff4le0g	415	3	,	,	,
cord-265941-eff4le0g	415	4	has	have	VBZ
cord-265941-eff4le0g	415	5	been	be	VBN
cord-265941-eff4le0g	415	6	shown	show	VBN
cord-265941-eff4le0g	415	7	to	to	TO
cord-265941-eff4le0g	415	8	play	play	VB
cord-265941-eff4le0g	415	9	a	a	DT
cord-265941-eff4le0g	415	10	role	role	NN
cord-265941-eff4le0g	415	11	in	in	IN
cord-265941-eff4le0g	415	12	numerous	numerous	JJ
cord-265941-eff4le0g	415	13	cellular	cellular	JJ
cord-265941-eff4le0g	415	14	processes	process	NNS
cord-265941-eff4le0g	415	15	associated	associate	VBN
cord-265941-eff4le0g	415	16	with	with	IN
cord-265941-eff4le0g	415	17	pathogen	pathogen	NN
cord-265941-eff4le0g	415	18	control	control	NN
cord-265941-eff4le0g	415	19	,	,	,
cord-265941-eff4le0g	415	20	including	include	VBG
cord-265941-eff4le0g	415	21	vesicular	vesicular	JJ
cord-265941-eff4le0g	415	22	trafficking	trafficking	NN
cord-265941-eff4le0g	415	23	,	,	,
cord-265941-eff4le0g	415	24	microtubule	microtubule	NN
cord-265941-eff4le0g	415	25	binding	binding	NN
cord-265941-eff4le0g	415	26	,	,	,
cord-265941-eff4le0g	415	27	autophagy	autophagy	NN
cord-265941-eff4le0g	415	28	and	and	CC
cord-265941-eff4le0g	415	29	mitophagy	mitophagy	NNS
cord-265941-eff4le0g	415	30	[	[	-LRB-
cord-265941-eff4le0g	415	31	214	214	CD
cord-265941-eff4le0g	415	32	]	]	-RRB-
cord-265941-eff4le0g	415	33	.	.	.
cord-265941-eff4le0g	416	1	One	one	CD
cord-265941-eff4le0g	416	2	of	of	IN
cord-265941-eff4le0g	416	3	the	the	DT
cord-265941-eff4le0g	416	4	first	first	JJ
cord-265941-eff4le0g	416	5	studies	study	NNS
cord-265941-eff4le0g	416	6	to	to	TO
cord-265941-eff4le0g	416	7	examine	examine	VB
cord-265941-eff4le0g	416	8	the	the	DT
cord-265941-eff4le0g	416	9	role	role	NN
cord-265941-eff4le0g	416	10	of	of	IN
cord-265941-eff4le0g	416	11	RIPK7	RIPK7	VBN
cord-265941-eff4le0g	416	12	in	in	IN
cord-265941-eff4le0g	416	13	innate	innate	JJ
cord-265941-eff4le0g	416	14	immunity	immunity	NN
cord-265941-eff4le0g	416	15	found	find	VBD
cord-265941-eff4le0g	416	16	that	that	IN
cord-265941-eff4le0g	416	17	RIPK7	ripk7	XX
cord-265941-eff4le0g	416	18	contributes	contribute	VBZ
cord-265941-eff4le0g	416	19	to	to	IN
cord-265941-eff4le0g	416	20	the	the	DT
cord-265941-eff4le0g	416	21	restriction	restriction	NN
cord-265941-eff4le0g	416	22	of	of	IN
cord-265941-eff4le0g	416	23	S.	S.	NNP
cord-265941-eff4le0g	416	24	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	416	25	by	by	IN
cord-265941-eff4le0g	416	26	macrophages	macrophage	NNS
cord-265941-eff4le0g	416	27	in	in	IN
cord-265941-eff4le0g	416	28	vitro	vitro	FW
cord-265941-eff4le0g	416	29	[	[	-LRB-
cord-265941-eff4le0g	416	30	215	215	CD
cord-265941-eff4le0g	416	31	]	]	-RRB-
cord-265941-eff4le0g	416	32	.	.	.
cord-265941-eff4le0g	417	1	This	this	DT
cord-265941-eff4le0g	417	2	was	be	VBD
cord-265941-eff4le0g	417	3	supported	support	VBN
cord-265941-eff4le0g	417	4	in	in	IN
cord-265941-eff4le0g	417	5	vivo	vivo	NNP
cord-265941-eff4le0g	417	6	as	as	IN
cord-265941-eff4le0g	417	7	Ripk7	Ripk7	NNS
cord-265941-eff4le0g	417	8	−	−	NNP
cord-265941-eff4le0g	418	1	/−	/−	.
cord-265941-eff4le0g	419	1	mice	mouse	NNS
cord-265941-eff4le0g	419	2	are	be	VBP
cord-265941-eff4le0g	419	3	more	more	RBR
cord-265941-eff4le0g	419	4	susceptible	susceptible	JJ
cord-265941-eff4le0g	419	5	to	to	IN
cord-265941-eff4le0g	419	6	S.	S.	NNP
cord-265941-eff4le0g	419	7	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	419	8	intraperitoneal	intraperitoneal	JJ
cord-265941-eff4le0g	419	9	infection	infection	NN
cord-265941-eff4le0g	419	10	,	,	,
cord-265941-eff4le0g	419	11	exhibiting	exhibit	VBG
cord-265941-eff4le0g	419	12	decreased	decrease	VBN
cord-265941-eff4le0g	419	13	IL-1β	il-1β	JJ
cord-265941-eff4le0g	419	14	secretion	secretion	NN
cord-265941-eff4le0g	419	15	,	,	,
cord-265941-eff4le0g	419	16	reduced	reduce	VBN
cord-265941-eff4le0g	419	17	neutrophil	neutrophil	NN
cord-265941-eff4le0g	419	18	infiltration	infiltration	NN
cord-265941-eff4le0g	419	19	,	,	,
cord-265941-eff4le0g	419	20	high	high	JJ
cord-265941-eff4le0g	419	21	bacterial	bacterial	JJ
cord-265941-eff4le0g	419	22	load	load	NN
cord-265941-eff4le0g	419	23	in	in	IN
cord-265941-eff4le0g	419	24	the	the	DT
cord-265941-eff4le0g	419	25	peritoneal	peritoneal	JJ
cord-265941-eff4le0g	419	26	cavity	cavity	NN
cord-265941-eff4le0g	419	27	and	and	CC
cord-265941-eff4le0g	419	28	overall	overall	JJ
cord-265941-eff4le0g	419	29	increased	increase	VBN
cord-265941-eff4le0g	419	30	mortality	mortality	NN
cord-265941-eff4le0g	419	31	[	[	-LRB-
cord-265941-eff4le0g	419	32	216	216	CD
cord-265941-eff4le0g	419	33	]	]	-RRB-
cord-265941-eff4le0g	419	34	.	.	.
cord-265941-eff4le0g	420	1	Mechanistically	Mechanistically	NNP
cord-265941-eff4le0g	420	2	,	,	,
cord-265941-eff4le0g	420	3	this	this	DT
cord-265941-eff4le0g	420	4	study	study	NN
cord-265941-eff4le0g	420	5	showed	show	VBD
cord-265941-eff4le0g	420	6	RIPK7	RIPK7	VBN
cord-265941-eff4le0g	420	7	forms	form	NNS
cord-265941-eff4le0g	420	8	a	a	DT
cord-265941-eff4le0g	420	9	complex	complex	NN
cord-265941-eff4le0g	420	10	with	with	IN
cord-265941-eff4le0g	420	11	the	the	DT
cord-265941-eff4le0g	420	12	NLRC4	NLRC4	NNP
cord-265941-eff4le0g	420	13	inflammasome	inflammasome	NN
cord-265941-eff4le0g	420	14	in	in	IN
cord-265941-eff4le0g	420	15	a	a	DT
cord-265941-eff4le0g	420	16	kinase	kinase	NN
cord-265941-eff4le0g	420	17	dependent	dependent	JJ
cord-265941-eff4le0g	420	18	manner	manner	NN
cord-265941-eff4le0g	420	19	,	,	,
cord-265941-eff4le0g	420	20	which	which	WDT
cord-265941-eff4le0g	420	21	then	then	RB
cord-265941-eff4le0g	420	22	promotes	promote	VBZ
cord-265941-eff4le0g	420	23	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	420	24	activation	activation	NN
cord-265941-eff4le0g	420	25	and	and	CC
cord-265941-eff4le0g	420	26	restriction	restriction	NN
cord-265941-eff4le0g	420	27	of	of	IN
cord-265941-eff4le0g	420	28	bacterial	bacterial	JJ
cord-265941-eff4le0g	420	29	growth	growth	NN
cord-265941-eff4le0g	420	30	during	during	IN
cord-265941-eff4le0g	420	31	infection	infection	NN
cord-265941-eff4le0g	420	32	[	[	-LRB-
cord-265941-eff4le0g	420	33	216	216	CD
cord-265941-eff4le0g	420	34	]	]	-RRB-
cord-265941-eff4le0g	420	35	.	.	.
cord-265941-eff4le0g	421	1	Similarly	similarly	RB
cord-265941-eff4le0g	421	2	,	,	,
cord-265941-eff4le0g	421	3	Ripk7	Ripk7	NNP
cord-265941-eff4le0g	421	4	-/mice	-/mice	NNP
cord-265941-eff4le0g	421	5	are	be	VBP
cord-265941-eff4le0g	421	6	more	more	RBR
cord-265941-eff4le0g	421	7	susceptible	susceptible	JJ
cord-265941-eff4le0g	421	8	to	to	IN
cord-265941-eff4le0g	421	9	oral	oral	JJ
cord-265941-eff4le0g	421	10	infection	infection	NN
cord-265941-eff4le0g	421	11	with	with	IN
cord-265941-eff4le0g	421	12	L.	L.	NNP
cord-265941-eff4le0g	421	13	monocytogenes	monocytogenes	NNP
cord-265941-eff4le0g	421	14	than	than	IN
cord-265941-eff4le0g	421	15	WT	WT	NNP
cord-265941-eff4le0g	421	16	mice	mouse	NNS
cord-265941-eff4le0g	421	17	[	[	-LRB-
cord-265941-eff4le0g	421	18	217	217	CD
cord-265941-eff4le0g	421	19	]	]	-RRB-
cord-265941-eff4le0g	421	20	.	.	.
cord-265941-eff4le0g	422	1	This	this	DT
cord-265941-eff4le0g	422	2	study	study	NN
cord-265941-eff4le0g	422	3	showed	show	VBD
cord-265941-eff4le0g	422	4	that	that	IN
cord-265941-eff4le0g	422	5	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	422	6	is	be	VBZ
cord-265941-eff4le0g	422	7	highly	highly	RB
cord-265941-eff4le0g	422	8	expressed	express	VBN
cord-265941-eff4le0g	422	9	in	in	IN
cord-265941-eff4le0g	422	10	lysozyme	lysozyme	NN
cord-265941-eff4le0g	422	11	-	-	HYPH
cord-265941-eff4le0g	422	12	positive	positive	JJ
cord-265941-eff4le0g	422	13	Paneth	Paneth	NNP
cord-265941-eff4le0g	422	14	cells	cell	NNS
cord-265941-eff4le0g	422	15	and	and	CC
cord-265941-eff4le0g	422	16	myeloid	myeloid	NN
cord-265941-eff4le0g	422	17	cells	cell	NNS
cord-265941-eff4le0g	422	18	within	within	IN
cord-265941-eff4le0g	422	19	the	the	DT
cord-265941-eff4le0g	422	20	lamina	lamina	JJ
cord-265941-eff4le0g	422	21	propria	propria	NN
cord-265941-eff4le0g	422	22	of	of	IN
cord-265941-eff4le0g	422	23	the	the	DT
cord-265941-eff4le0g	422	24	ileum	ileum	NN
cord-265941-eff4le0g	422	25	,	,	,
cord-265941-eff4le0g	422	26	suggesting	suggest	VBG
cord-265941-eff4le0g	422	27	RIPK7	ripk7	POS
cord-265941-eff4le0g	422	28	plays	play	VBZ
cord-265941-eff4le0g	422	29	a	a	DT
cord-265941-eff4le0g	422	30	protective	protective	JJ
cord-265941-eff4le0g	422	31	role	role	NN
cord-265941-eff4le0g	422	32	at	at	IN
cord-265941-eff4le0g	422	33	the	the	DT
cord-265941-eff4le0g	422	34	intestinal	intestinal	JJ
cord-265941-eff4le0g	422	35	mucosa	mucosa	NN
cord-265941-eff4le0g	422	36	.	.	.
cord-265941-eff4le0g	423	1	This	this	DT
cord-265941-eff4le0g	423	2	is	be	VBZ
cord-265941-eff4le0g	423	3	further	further	RB
cord-265941-eff4le0g	423	4	supported	support	VBN
cord-265941-eff4le0g	423	5	by	by	IN
cord-265941-eff4le0g	423	6	the	the	DT
cord-265941-eff4le0g	423	7	fact	fact	NN
cord-265941-eff4le0g	423	8	that	that	IN
cord-265941-eff4le0g	423	9	mutations	mutation	NNS
cord-265941-eff4le0g	423	10	in	in	IN
cord-265941-eff4le0g	423	11	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	423	12	are	be	VBP
cord-265941-eff4le0g	423	13	associated	associate	VBN
cord-265941-eff4le0g	423	14	with	with	IN
cord-265941-eff4le0g	423	15	increased	increase	VBN
cord-265941-eff4le0g	423	16	severity	severity	NN
cord-265941-eff4le0g	423	17	of	of	IN
cord-265941-eff4le0g	423	18	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	423	19	bowel	bowel	NN
cord-265941-eff4le0g	423	20	disease	disease	NN
cord-265941-eff4le0g	423	21	[	[	-LRB-
cord-265941-eff4le0g	423	22	218	218	CD
cord-265941-eff4le0g	423	23	]	]	-RRB-
cord-265941-eff4le0g	423	24	.	.	.
cord-265941-eff4le0g	424	1	Similar	similar	JJ
cord-265941-eff4le0g	424	2	to	to	IN
cord-265941-eff4le0g	424	3	RIPK2	ripk2	XX
cord-265941-eff4le0g	424	4	,	,	,
cord-265941-eff4le0g	424	5	polymorphisms	polymorphism	NNS
cord-265941-eff4le0g	424	6	in	in	IN
cord-265941-eff4le0g	424	7	RIPK7	RIPK7	NNS
cord-265941-eff4le0g	424	8	are	be	VBP
cord-265941-eff4le0g	424	9	associated	associate	VBN
cord-265941-eff4le0g	424	10	with	with	IN
cord-265941-eff4le0g	424	11	the	the	DT
cord-265941-eff4le0g	424	12	development	development	NN
cord-265941-eff4le0g	424	13	of	of	IN
cord-265941-eff4le0g	424	14	multibacillary	multibacillary	JJ
cord-265941-eff4le0g	424	15	leprosy	leprosy	NN
cord-265941-eff4le0g	424	16	caused	cause	VBN
cord-265941-eff4le0g	424	17	by	by	IN
cord-265941-eff4le0g	424	18	M.	M.	NNP
cord-265941-eff4le0g	424	19	leprae	leprae	NNP
cord-265941-eff4le0g	424	20	[	[	-LRB-
cord-265941-eff4le0g	424	21	152	152	CD
cord-265941-eff4le0g	424	22	,	,	,
cord-265941-eff4le0g	424	23	219	219	CD
cord-265941-eff4le0g	424	24	,	,	,
cord-265941-eff4le0g	424	25	Fig	Fig	NNP
cord-265941-eff4le0g	424	26	.	.	NNP
cord-265941-eff4le0g	424	27	4	4	CD
cord-265941-eff4le0g	424	28	.	.	.
cord-265941-eff4le0g	425	1	Cellular	cellular	JJ
cord-265941-eff4le0g	425	2	responses	response	NNS
cord-265941-eff4le0g	425	3	to	to	IN
cord-265941-eff4le0g	425	4	bacterial	bacterial	JJ
cord-265941-eff4le0g	425	5	infection	infection	NN
cord-265941-eff4le0g	425	6	mediated	mediate	VBN
cord-265941-eff4le0g	425	7	by	by	IN
cord-265941-eff4le0g	425	8	RIPK7	ripk7	XX
cord-265941-eff4le0g	426	1	(	(	-LRB-
cord-265941-eff4le0g	426	2	LRRK2	LRRK2	NNP
cord-265941-eff4le0g	426	3	)	)	-RRB-
cord-265941-eff4le0g	426	4	.	.	.
cord-265941-eff4le0g	427	1	Sensing	sensing	NN
cord-265941-eff4le0g	427	2	of	of	IN
cord-265941-eff4le0g	427	3	LPS	LPS	NNP
cord-265941-eff4le0g	427	4	by	by	IN
cord-265941-eff4le0g	427	5	TLR4	TLR4	NNP
cord-265941-eff4le0g	427	6	promotes	promote	VBZ
cord-265941-eff4le0g	427	7	localization	localization	NN
cord-265941-eff4le0g	427	8	of	of	IN
cord-265941-eff4le0g	427	9	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	427	10	to	to	IN
cord-265941-eff4le0g	427	11	endosomal	endosomal	NNP
cord-265941-eff4le0g	427	12	membranes	membrane	NNS
cord-265941-eff4le0g	427	13	[	[	-LRB-
cord-265941-eff4le0g	427	14	225	225	CD
cord-265941-eff4le0g	427	15	,	,	,
cord-265941-eff4le0g	427	16	226	226	CD
cord-265941-eff4le0g	427	17	]	]	-RRB-
cord-265941-eff4le0g	427	18	.	.	.
cord-265941-eff4le0g	428	1	Here	here	RB
cord-265941-eff4le0g	428	2	,	,	,
cord-265941-eff4le0g	428	3	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	428	4	can	can	MD
cord-265941-eff4le0g	428	5	be	be	VB
cord-265941-eff4le0g	428	6	exploited	exploit	VBN
cord-265941-eff4le0g	428	7	by	by	IN
cord-265941-eff4le0g	428	8	M.	M.	NNP
cord-265941-eff4le0g	428	9	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	428	10	(	(	-LRB-
cord-265941-eff4le0g	428	11	Mtb	Mtb	NNP
cord-265941-eff4le0g	428	12	)	)	-RRB-
cord-265941-eff4le0g	428	13	to	to	TO
cord-265941-eff4le0g	428	14	promote	promote	VB
cord-265941-eff4le0g	428	15	bacterial	bacterial	JJ
cord-265941-eff4le0g	428	16	replication	replication	NN
cord-265941-eff4le0g	428	17	,	,	,
cord-265941-eff4le0g	428	18	as	as	IN
cord-265941-eff4le0g	428	19	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	428	20	recruits	recruit	VBZ
cord-265941-eff4le0g	428	21	Rubicon	Rubicon	NNP
cord-265941-eff4le0g	428	22	to	to	IN
cord-265941-eff4le0g	428	23	the	the	DT
cord-265941-eff4le0g	428	24	endosome	endosome	NN
cord-265941-eff4le0g	428	25	,	,	,
cord-265941-eff4le0g	428	26	where	where	WRB
cord-265941-eff4le0g	428	27	this	this	DT
cord-265941-eff4le0g	428	28	complexes	complex	NNS
cord-265941-eff4le0g	428	29	with	with	IN
cord-265941-eff4le0g	428	30	PI3	PI3	NNP
cord-265941-eff4le0g	428	31	K	K	NNP
cord-265941-eff4le0g	428	32	to	to	TO
cord-265941-eff4le0g	428	33	prevent	prevent	VB
cord-265941-eff4le0g	428	34	further	further	JJ
cord-265941-eff4le0g	428	35	phagosome	phagosome	NN
cord-265941-eff4le0g	428	36	maturation	maturation	NN
cord-265941-eff4le0g	428	37	[	[	-LRB-
cord-265941-eff4le0g	428	38	222	222	CD
cord-265941-eff4le0g	428	39	]	]	-RRB-
cord-265941-eff4le0g	428	40	.	.	.
cord-265941-eff4le0g	429	1	Following	follow	VBG
cord-265941-eff4le0g	429	2	priming	prime	VBG
cord-265941-eff4le0g	429	3	by	by	IN
cord-265941-eff4le0g	429	4	PRRs	prr	NNS
cord-265941-eff4le0g	429	5	,	,	,
cord-265941-eff4le0g	429	6	detection	detection	NN
cord-265941-eff4le0g	429	7	of	of	IN
cord-265941-eff4le0g	429	8	S.	S.	NNP
cord-265941-eff4le0g	429	9	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	429	10	bacterial	bacterial	JJ
cord-265941-eff4le0g	429	11	components	component	NNS
cord-265941-eff4le0g	429	12	such	such	JJ
cord-265941-eff4le0g	429	13	as	as	IN
cord-265941-eff4le0g	429	14	flagellin	flagellin	NNP
cord-265941-eff4le0g	429	15	(	(	-LRB-
cord-265941-eff4le0g	429	16	or	or	CC
cord-265941-eff4le0g	429	17	Type	Type	NNP
cord-265941-eff4le0g	429	18	III	III	NNP
cord-265941-eff4le0g	429	19	Secretion	Secretion	NNP
cord-265941-eff4le0g	429	20	System	System	NNP
cord-265941-eff4le0g	429	21	rod	rod	NN
cord-265941-eff4le0g	429	22	proteins	protein	NNS
cord-265941-eff4le0g	429	23	)	)	-RRB-
cord-265941-eff4le0g	429	24	by	by	IN
cord-265941-eff4le0g	429	25	NAIP	NAIP	NNP
cord-265941-eff4le0g	429	26	family	family	NN
cord-265941-eff4le0g	429	27	members	member	NNS
cord-265941-eff4le0g	429	28	induces	induce	VBZ
cord-265941-eff4le0g	429	29	NLRC4	NLRC4	NNP
cord-265941-eff4le0g	429	30	activation	activation	NN
cord-265941-eff4le0g	429	31	[	[	-LRB-
cord-265941-eff4le0g	429	32	227	227	CD
cord-265941-eff4le0g	429	33	]	]	-RRB-
cord-265941-eff4le0g	429	34	.	.	.
cord-265941-eff4le0g	430	1	In	in	IN
cord-265941-eff4le0g	430	2	contrast	contrast	NN
cord-265941-eff4le0g	430	3	to	to	IN
cord-265941-eff4le0g	430	4	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	430	5	's	's	POS
cord-265941-eff4le0g	430	6	role	role	NN
cord-265941-eff4le0g	430	7	in	in	IN
cord-265941-eff4le0g	430	8	Mtb	Mtb	NNP
cord-265941-eff4le0g	430	9	infection	infection	NN
cord-265941-eff4le0g	430	10	,	,	,
cord-265941-eff4le0g	430	11	kinase	kinase	NN
cord-265941-eff4le0g	430	12	-	-	HYPH
cord-265941-eff4le0g	430	13	dependent	dependent	JJ
cord-265941-eff4le0g	430	14	interactions	interaction	NNS
cord-265941-eff4le0g	430	15	between	between	IN
cord-265941-eff4le0g	430	16	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	430	17	and	and	CC
cord-265941-eff4le0g	430	18	NLRC4	NLRC4	NNP
cord-265941-eff4le0g	430	19	promote	promote	VBP
cord-265941-eff4le0g	430	20	efficient	efficient	JJ
cord-265941-eff4le0g	430	21	inflammasome	inflammasome	NN
cord-265941-eff4le0g	430	22	assembly	assembly	NN
cord-265941-eff4le0g	430	23	and	and	CC
cord-265941-eff4le0g	430	24	aid	aid	VB
cord-265941-eff4le0g	430	25	downstream	downstream	JJ
cord-265941-eff4le0g	430	26	restriction	restriction	NN
cord-265941-eff4le0g	430	27	of	of	IN
cord-265941-eff4le0g	430	28	bacterial	bacterial	JJ
cord-265941-eff4le0g	430	29	growth	growth	NN
cord-265941-eff4le0g	430	30	[	[	-LRB-
cord-265941-eff4le0g	430	31	216	216	CD
cord-265941-eff4le0g	430	32	]	]	-RRB-
cord-265941-eff4le0g	430	33	.	.	.
cord-265941-eff4le0g	431	1	220	220	CD
cord-265941-eff4le0g	431	2	]	]	-RRB-
cord-265941-eff4le0g	431	3	and	and	CC
cord-265941-eff4le0g	431	4	Mtb	Mtb	NNP
cord-265941-eff4le0g	431	5	infection	infection	NN
cord-265941-eff4le0g	431	6	[	[	-LRB-
cord-265941-eff4le0g	431	7	221	221	CD
cord-265941-eff4le0g	431	8	]	]	-RRB-
cord-265941-eff4le0g	431	9	.	.	.
cord-265941-eff4le0g	432	1	A	a	DT
cord-265941-eff4le0g	432	2	recent	recent	JJ
cord-265941-eff4le0g	432	3	study	study	NN
cord-265941-eff4le0g	432	4	identified	identify	VBD
cord-265941-eff4le0g	432	5	a	a	DT
cord-265941-eff4le0g	432	6	mechanism	mechanism	NN
cord-265941-eff4le0g	432	7	whereby	whereby	WRB
cord-265941-eff4le0g	432	8	RIPK7	RIPK7	VBD
cord-265941-eff4le0g	432	9	negatively	negatively	RB
cord-265941-eff4le0g	432	10	regulates	regulate	VBZ
cord-265941-eff4le0g	432	11	phagosome	phagosome	NN
cord-265941-eff4le0g	432	12	maturation	maturation	NN
cord-265941-eff4le0g	432	13	in	in	IN
cord-265941-eff4le0g	432	14	macrophages	macrophage	NNS
cord-265941-eff4le0g	432	15	by	by	IN
cord-265941-eff4le0g	432	16	controlling	control	VBG
cord-265941-eff4le0g	432	17	Rubicon	Rubicon	NNP
cord-265941-eff4le0g	432	18	/	/	SYM
cord-265941-eff4le0g	432	19	PI3	pi3	NN
cord-265941-eff4le0g	432	20	K	K	NNP
cord-265941-eff4le0g	432	21	activity	activity	NN
cord-265941-eff4le0g	432	22	on	on	IN
cord-265941-eff4le0g	432	23	phagosomes	phagosome	NNS
cord-265941-eff4le0g	432	24	in	in	IN
cord-265941-eff4le0g	432	25	a	a	DT
cord-265941-eff4le0g	432	26	kinase	kinase	NN
cord-265941-eff4le0g	432	27	dependent	dependent	JJ
cord-265941-eff4le0g	432	28	manner	manner	NN
cord-265941-eff4le0g	432	29	,	,	,
cord-265941-eff4le0g	432	30	resulting	result	VBG
cord-265941-eff4le0g	432	31	in	in	IN
cord-265941-eff4le0g	432	32	impaired	impaired	JJ
cord-265941-eff4le0g	432	33	immune	immune	JJ
cord-265941-eff4le0g	432	34	responses	response	NNS
cord-265941-eff4le0g	432	35	and	and	CC
cord-265941-eff4le0g	432	36	promotion	promotion	NN
cord-265941-eff4le0g	432	37	of	of	IN
cord-265941-eff4le0g	432	38	Mtb	Mtb	NNP
cord-265941-eff4le0g	432	39	replication	replication	NN
cord-265941-eff4le0g	432	40	[	[	-LRB-
cord-265941-eff4le0g	432	41	222	222	CD
cord-265941-eff4le0g	432	42	]	]	-RRB-
cord-265941-eff4le0g	433	1	(	(	-LRB-
cord-265941-eff4le0g	433	2	Fig	Fig	NNP
cord-265941-eff4le0g	433	3	.	.	NNP
cord-265941-eff4le0g	433	4	4	4	CD
cord-265941-eff4le0g	433	5	)	)	-RRB-
cord-265941-eff4le0g	433	6	.	.	.
cord-265941-eff4le0g	434	1	Contradictory	contradictory	JJ
cord-265941-eff4le0g	434	2	to	to	IN
cord-265941-eff4le0g	434	3	the	the	DT
cord-265941-eff4le0g	434	4	requirement	requirement	NN
cord-265941-eff4le0g	434	5	of	of	IN
cord-265941-eff4le0g	434	6	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	434	7	for	for	IN
cord-265941-eff4le0g	434	8	the	the	DT
cord-265941-eff4le0g	434	9	control	control	NN
cord-265941-eff4le0g	434	10	of	of	IN
cord-265941-eff4le0g	434	11	Salmonella	Salmonella	NNP
cord-265941-eff4le0g	434	12	and	and	CC
cord-265941-eff4le0g	434	13	Listeria	Listeria	NNP
cord-265941-eff4le0g	434	14	infection	infection	NN
cord-265941-eff4le0g	434	15	,	,	,
cord-265941-eff4le0g	434	16	RIPK7-deficiency	RIPK7-deficiency	NNP
cord-265941-eff4le0g	434	17	in	in	IN
cord-265941-eff4le0g	434	18	macrophages	macrophage	NNS
cord-265941-eff4le0g	434	19	or	or	CC
cord-265941-eff4le0g	434	20	mice	mice	NN
cord-265941-eff4le0g	434	21	results	result	NNS
cord-265941-eff4le0g	434	22	in	in	IN
cord-265941-eff4le0g	434	23	improved	improved	JJ
cord-265941-eff4le0g	434	24	control	control	NN
cord-265941-eff4le0g	434	25	of	of	IN
cord-265941-eff4le0g	434	26	Mtb	Mtb	NNP
cord-265941-eff4le0g	434	27	infection	infection	NN
cord-265941-eff4le0g	434	28	,	,	,
cord-265941-eff4le0g	434	29	which	which	WDT
cord-265941-eff4le0g	434	30	supports	support	VBZ
cord-265941-eff4le0g	434	31	a	a	DT
cord-265941-eff4le0g	434	32	specific	specific	JJ
cord-265941-eff4le0g	434	33	role	role	NN
cord-265941-eff4le0g	434	34	for	for	IN
cord-265941-eff4le0g	434	35	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	434	36	in	in	IN
cord-265941-eff4le0g	434	37	mycobacterial	mycobacterial	JJ
cord-265941-eff4le0g	434	38	control	control	NN
cord-265941-eff4le0g	434	39	via	via	IN
cord-265941-eff4le0g	434	40	the	the	DT
cord-265941-eff4le0g	434	41	regulation	regulation	NN
cord-265941-eff4le0g	434	42	of	of	IN
cord-265941-eff4le0g	434	43	degradative	degradative	JJ
cord-265941-eff4le0g	434	44	pathways	pathway	NNS
cord-265941-eff4le0g	434	45	[	[	-LRB-
cord-265941-eff4le0g	434	46	222	222	CD
cord-265941-eff4le0g	434	47	]	]	-RRB-
cord-265941-eff4le0g	434	48	.	.	.
cord-265941-eff4le0g	435	1	Ripk7	Ripk7	NNP
cord-265941-eff4le0g	436	1	−	−	NNP
cord-265941-eff4le0g	437	1	/−	/−	.
cord-265941-eff4le0g	438	1	mice	mouse	NNS
cord-265941-eff4le0g	438	2	exhibit	exhibit	VBP
cord-265941-eff4le0g	438	3	increased	increase	VBN
cord-265941-eff4le0g	438	4	transcription	transcription	NN
cord-265941-eff4le0g	438	5	of	of	IN
cord-265941-eff4le0g	438	6	type	type	NN
cord-265941-eff4le0g	438	7	II	II	NNP
cord-265941-eff4le0g	438	8	IFN	IFN	NNP
cord-265941-eff4le0g	438	9	,	,	,
cord-265941-eff4le0g	438	10	but	but	CC
cord-265941-eff4le0g	438	11	decreased	decrease	VBD
cord-265941-eff4le0g	438	12	transcription	transcription	NN
cord-265941-eff4le0g	438	13	of	of	IN
cord-265941-eff4le0g	438	14	type	type	NN
cord-265941-eff4le0g	439	1	I	-PRON-	PRP
cord-265941-eff4le0g	439	2	IFN	IFN	NNP
cord-265941-eff4le0g	439	3	during	during	IN
cord-265941-eff4le0g	439	4	Mtb	Mtb	NNP
cord-265941-eff4le0g	439	5	infection	infection	NN
cord-265941-eff4le0g	439	6	[	[	-LRB-
cord-265941-eff4le0g	439	7	222	222	CD
cord-265941-eff4le0g	439	8	]	]	-RRB-
cord-265941-eff4le0g	439	9	,	,	,
cord-265941-eff4le0g	439	10	and	and	CC
cord-265941-eff4le0g	439	11	RIPK7-deficient	ripk7-deficient	NN
cord-265941-eff4le0g	439	12	macrophages	macrophage	NNS
cord-265941-eff4le0g	439	13	fail	fail	VBP
cord-265941-eff4le0g	439	14	to	to	TO
cord-265941-eff4le0g	439	15	induce	induce	VB
cord-265941-eff4le0g	439	16	type	type	NN
cord-265941-eff4le0g	440	1	I	-PRON-	PRP
cord-265941-eff4le0g	440	2	IFN	IFN	NNP
cord-265941-eff4le0g	440	3	in	in	IN
cord-265941-eff4le0g	440	4	vitro	vitro	FW
cord-265941-eff4le0g	440	5	when	when	WRB
cord-265941-eff4le0g	440	6	infected	infect	VBN
cord-265941-eff4le0g	440	7	with	with	IN
cord-265941-eff4le0g	440	8	Mtb	Mtb	NNP
cord-265941-eff4le0g	440	9	[	[	-LRB-
cord-265941-eff4le0g	440	10	223	223	CD
cord-265941-eff4le0g	440	11	]	]	-RRB-
cord-265941-eff4le0g	440	12	.	.	.
cord-265941-eff4le0g	441	1	Mechanistically	Mechanistically	NNP
cord-265941-eff4le0g	441	2	,	,	,
cord-265941-eff4le0g	441	3	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	441	4	regulates	regulate	VBZ
cord-265941-eff4le0g	441	5	type	type	NN
cord-265941-eff4le0g	441	6	I	-PRON-	PRP
cord-265941-eff4le0g	441	7	IFN	IFN	NNP
cord-265941-eff4le0g	441	8	gene	gene	NN
cord-265941-eff4le0g	441	9	expression	expression	NN
cord-265941-eff4le0g	441	10	by	by	IN
cord-265941-eff4le0g	441	11	maintaining	maintain	VBG
cord-265941-eff4le0g	441	12	mitochondrial	mitochondrial	JJ
cord-265941-eff4le0g	441	13	homeostasis	homeostasis	NN
cord-265941-eff4le0g	441	14	[	[	-LRB-
cord-265941-eff4le0g	441	15	223	223	CD
cord-265941-eff4le0g	441	16	]	]	-RRB-
cord-265941-eff4le0g	441	17	.	.	.
cord-265941-eff4le0g	442	1	Given	give	VBN
cord-265941-eff4le0g	442	2	that	that	DT
cord-265941-eff4le0g	442	3	production	production	NN
cord-265941-eff4le0g	442	4	of	of	IN
cord-265941-eff4le0g	442	5	type	type	NN
cord-265941-eff4le0g	443	1	I	-PRON-	PRP
cord-265941-eff4le0g	443	2	IFNs	ifns	VBP
cord-265941-eff4le0g	443	3	during	during	IN
cord-265941-eff4le0g	443	4	Mtb	Mtb	NNP
cord-265941-eff4le0g	443	5	infection	infection	NN
cord-265941-eff4le0g	443	6	have	have	VBP
cord-265941-eff4le0g	443	7	been	be	VBN
cord-265941-eff4le0g	443	8	shown	show	VBN
cord-265941-eff4le0g	443	9	to	to	TO
cord-265941-eff4le0g	443	10	promote	promote	VB
cord-265941-eff4le0g	443	11	disease	disease	NN
cord-265941-eff4le0g	443	12	[	[	-LRB-
cord-265941-eff4le0g	443	13	224	224	CD
cord-265941-eff4le0g	443	14	]	]	-RRB-
cord-265941-eff4le0g	443	15	,	,	,
cord-265941-eff4le0g	443	16	this	this	DT
cord-265941-eff4le0g	443	17	may	may	MD
cord-265941-eff4le0g	443	18	explain	explain	VB
cord-265941-eff4le0g	443	19	why	why	WRB
cord-265941-eff4le0g	443	20	Mtb	Mtb	NNP
cord-265941-eff4le0g	443	21	infection	infection	NN
cord-265941-eff4le0g	443	22	is	be	VBZ
cord-265941-eff4le0g	443	23	limited	limit	VBN
cord-265941-eff4le0g	443	24	in	in	IN
cord-265941-eff4le0g	443	25	the	the	DT
cord-265941-eff4le0g	443	26	absence	absence	NN
cord-265941-eff4le0g	443	27	of	of	IN
cord-265941-eff4le0g	443	28	RIPK7	RIPK7	NNS
cord-265941-eff4le0g	443	29	.	.	.
cord-265941-eff4le0g	444	1	Thus	thus	RB
cord-265941-eff4le0g	444	2	,	,	,
cord-265941-eff4le0g	444	3	RIPK7	RIPK7	VBN
cord-265941-eff4le0g	444	4	acts	act	NNS
cord-265941-eff4le0g	444	5	as	as	IN
cord-265941-eff4le0g	444	6	a	a	DT
cord-265941-eff4le0g	444	7	regulator	regulator	NN
cord-265941-eff4le0g	444	8	of	of	IN
cord-265941-eff4le0g	444	9	early	early	JJ
cord-265941-eff4le0g	444	10	clearance	clearance	NN
cord-265941-eff4le0g	444	11	of	of	IN
cord-265941-eff4le0g	444	12	Mtb	Mtb	NNP
cord-265941-eff4le0g	444	13	and	and	CC
cord-265941-eff4le0g	444	14	given	give	VBN
cord-265941-eff4le0g	444	15	its	-PRON-	PRP$
cord-265941-eff4le0g	444	16	function	function	NN
cord-265941-eff4le0g	444	17	is	be	VBZ
cord-265941-eff4le0g	444	18	kinase	kinase	VBN
cord-265941-eff4le0g	444	19	dependent	dependent	JJ
cord-265941-eff4le0g	444	20	,	,	,
cord-265941-eff4le0g	444	21	there	there	EX
cord-265941-eff4le0g	444	22	may	may	MD
cord-265941-eff4le0g	444	23	be	be	VB
cord-265941-eff4le0g	444	24	therapeutic	therapeutic	JJ
cord-265941-eff4le0g	444	25	potential	potential	NN
cord-265941-eff4le0g	444	26	for	for	IN
cord-265941-eff4le0g	444	27	RIPK7-specific	RIPK7-specific	NNP
cord-265941-eff4le0g	444	28	kinase	kinase	NN
cord-265941-eff4le0g	444	29	inhibitors	inhibitor	NNS
cord-265941-eff4le0g	444	30	in	in	IN
cord-265941-eff4le0g	444	31	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	444	32	.	.	.
cord-265941-eff4le0g	445	1	Sensing	sensing	NN
cord-265941-eff4le0g	445	2	of	of	IN
cord-265941-eff4le0g	445	3	LPS	LPS	NNP
cord-265941-eff4le0g	445	4	by	by	IN
cord-265941-eff4le0g	445	5	TLR4	TLR4	NNP
cord-265941-eff4le0g	445	6	promotes	promote	VBZ
cord-265941-eff4le0g	445	7	localization	localization	NN
cord-265941-eff4le0g	445	8	of	of	IN
cord-265941-eff4le0g	445	9	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	445	10	to	to	IN
cord-265941-eff4le0g	445	11	endosomal	endosomal	NNP
cord-265941-eff4le0g	445	12	membranes	membrane	NNS
cord-265941-eff4le0g	445	13	[	[	-LRB-
cord-265941-eff4le0g	445	14	225	225	CD
cord-265941-eff4le0g	445	15	,	,	,
cord-265941-eff4le0g	445	16	226	226	CD
cord-265941-eff4le0g	445	17	]	]	-RRB-
cord-265941-eff4le0g	445	18	.	.	.
cord-265941-eff4le0g	446	1	Here	here	RB
cord-265941-eff4le0g	446	2	,	,	,
cord-265941-eff4le0g	446	3	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	446	4	can	can	MD
cord-265941-eff4le0g	446	5	be	be	VB
cord-265941-eff4le0g	446	6	exploited	exploit	VBN
cord-265941-eff4le0g	446	7	by	by	IN
cord-265941-eff4le0g	446	8	M.	M.	NNP
cord-265941-eff4le0g	446	9	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	446	10	(	(	-LRB-
cord-265941-eff4le0g	446	11	Mtb	Mtb	NNP
cord-265941-eff4le0g	446	12	)	)	-RRB-
cord-265941-eff4le0g	446	13	to	to	TO
cord-265941-eff4le0g	446	14	promote	promote	VB
cord-265941-eff4le0g	446	15	bacterial	bacterial	JJ
cord-265941-eff4le0g	446	16	replication	replication	NN
cord-265941-eff4le0g	446	17	,	,	,
cord-265941-eff4le0g	446	18	as	as	IN
cord-265941-eff4le0g	446	19	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	446	20	recruits	recruit	VBZ
cord-265941-eff4le0g	446	21	Rubicon	Rubicon	NNP
cord-265941-eff4le0g	446	22	to	to	IN
cord-265941-eff4le0g	446	23	the	the	DT
cord-265941-eff4le0g	446	24	endosome	endosome	NN
cord-265941-eff4le0g	446	25	,	,	,
cord-265941-eff4le0g	446	26	where	where	WRB
cord-265941-eff4le0g	446	27	this	this	DT
cord-265941-eff4le0g	446	28	complexes	complex	NNS
cord-265941-eff4le0g	446	29	with	with	IN
cord-265941-eff4le0g	446	30	PI3	PI3	NNP
cord-265941-eff4le0g	446	31	K	K	NNP
cord-265941-eff4le0g	446	32	to	to	TO
cord-265941-eff4le0g	446	33	prevent	prevent	VB
cord-265941-eff4le0g	446	34	further	further	JJ
cord-265941-eff4le0g	446	35	phagosome	phagosome	NN
cord-265941-eff4le0g	446	36	maturation	maturation	NN
cord-265941-eff4le0g	446	37	[	[	-LRB-
cord-265941-eff4le0g	446	38	222	222	CD
cord-265941-eff4le0g	446	39	]	]	-RRB-
cord-265941-eff4le0g	446	40	.	.	.
cord-265941-eff4le0g	447	1	Following	follow	VBG
cord-265941-eff4le0g	447	2	priming	prime	VBG
cord-265941-eff4le0g	447	3	by	by	IN
cord-265941-eff4le0g	447	4	PRRs	prr	NNS
cord-265941-eff4le0g	447	5	,	,	,
cord-265941-eff4le0g	447	6	detection	detection	NN
cord-265941-eff4le0g	447	7	of	of	IN
cord-265941-eff4le0g	447	8	S.	S.	NNP
cord-265941-eff4le0g	447	9	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	447	10	bacterial	bacterial	JJ
cord-265941-eff4le0g	447	11	components	component	NNS
cord-265941-eff4le0g	447	12	such	such	JJ
cord-265941-eff4le0g	447	13	as	as	IN
cord-265941-eff4le0g	447	14	flagellin	flagellin	NNP
cord-265941-eff4le0g	447	15	(	(	-LRB-
cord-265941-eff4le0g	447	16	or	or	CC
cord-265941-eff4le0g	447	17	Type	Type	NNP
cord-265941-eff4le0g	447	18	III	III	NNP
cord-265941-eff4le0g	447	19	Secretion	Secretion	NNP
cord-265941-eff4le0g	447	20	System	System	NNP
cord-265941-eff4le0g	447	21	rod	rod	NN
cord-265941-eff4le0g	447	22	proteins	protein	NNS
cord-265941-eff4le0g	447	23	)	)	-RRB-
cord-265941-eff4le0g	447	24	by	by	IN
cord-265941-eff4le0g	447	25	NAIP	NAIP	NNP
cord-265941-eff4le0g	447	26	family	family	NN
cord-265941-eff4le0g	447	27	members	member	NNS
cord-265941-eff4le0g	447	28	induces	induce	VBZ
cord-265941-eff4le0g	447	29	NLRC4	NLRC4	NNP
cord-265941-eff4le0g	447	30	activation	activation	NN
cord-265941-eff4le0g	447	31	[	[	-LRB-
cord-265941-eff4le0g	447	32	227	227	CD
cord-265941-eff4le0g	447	33	]	]	-RRB-
cord-265941-eff4le0g	447	34	.	.	.
cord-265941-eff4le0g	448	1	In	in	IN
cord-265941-eff4le0g	448	2	contrast	contrast	NN
cord-265941-eff4le0g	448	3	to	to	IN
cord-265941-eff4le0g	448	4	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	448	5	's	's	POS
cord-265941-eff4le0g	448	6	role	role	NN
cord-265941-eff4le0g	448	7	in	in	IN
cord-265941-eff4le0g	448	8	Mtb	Mtb	NNP
cord-265941-eff4le0g	448	9	infection	infection	NN
cord-265941-eff4le0g	448	10	,	,	,
cord-265941-eff4le0g	448	11	kinase	kinase	NN
cord-265941-eff4le0g	448	12	-	-	HYPH
cord-265941-eff4le0g	448	13	dependent	dependent	JJ
cord-265941-eff4le0g	448	14	interactions	interaction	NNS
cord-265941-eff4le0g	448	15	between	between	IN
cord-265941-eff4le0g	448	16	RIPK7	RIPK7	NNP
cord-265941-eff4le0g	448	17	and	and	CC
cord-265941-eff4le0g	448	18	NLRC4	NLRC4	NNP
cord-265941-eff4le0g	448	19	promote	promote	VBP
cord-265941-eff4le0g	448	20	efficient	efficient	JJ
cord-265941-eff4le0g	448	21	inflammasome	inflammasome	NN
cord-265941-eff4le0g	448	22	assembly	assembly	NN
cord-265941-eff4le0g	448	23	and	and	CC
cord-265941-eff4le0g	448	24	aid	aid	VB
cord-265941-eff4le0g	448	25	downstream	downstream	JJ
cord-265941-eff4le0g	448	26	restriction	restriction	NN
cord-265941-eff4le0g	448	27	of	of	IN
cord-265941-eff4le0g	448	28	bacterial	bacterial	JJ
cord-265941-eff4le0g	448	29	growth	growth	NN
cord-265941-eff4le0g	448	30	[	[	-LRB-
cord-265941-eff4le0g	448	31	216	216	CD
cord-265941-eff4le0g	448	32	]	]	-RRB-
cord-265941-eff4le0g	448	33	.	.	.
cord-265941-eff4le0g	449	1	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	449	2	,	,	,
cord-265941-eff4le0g	449	3	2	2	CD
cord-265941-eff4le0g	449	4	,	,	,
cord-265941-eff4le0g	449	5	3	3	CD
cord-265941-eff4le0g	449	6	and	and	CC
cord-265941-eff4le0g	449	7	7	7	CD
cord-265941-eff4le0g	449	8	have	have	VBP
cord-265941-eff4le0g	449	9	emerged	emerge	VBN
cord-265941-eff4le0g	449	10	as	as	IN
cord-265941-eff4le0g	449	11	critical	critical	JJ
cord-265941-eff4le0g	449	12	mediators	mediator	NNS
cord-265941-eff4le0g	449	13	of	of	IN
cord-265941-eff4le0g	449	14	inflammation	inflammation	NN
cord-265941-eff4le0g	449	15	and	and	CC
cord-265941-eff4le0g	449	16	innate	innate	JJ
cord-265941-eff4le0g	449	17	immunity	immunity	NN
cord-265941-eff4le0g	449	18	in	in	IN
cord-265941-eff4le0g	449	19	response	response	NN
cord-265941-eff4le0g	449	20	to	to	IN
cord-265941-eff4le0g	449	21	multiple	multiple	JJ
cord-265941-eff4le0g	449	22	diverse	diverse	JJ
cord-265941-eff4le0g	449	23	pathogens	pathogen	NNS
cord-265941-eff4le0g	449	24	.	.	.
cord-265941-eff4le0g	450	1	Not	not	RB
cord-265941-eff4le0g	450	2	surprisingly	surprisingly	RB
cord-265941-eff4le0g	450	3	,	,	,
cord-265941-eff4le0g	450	4	many	many	JJ
cord-265941-eff4le0g	450	5	pathogens	pathogen	NNS
cord-265941-eff4le0g	450	6	have	have	VBP
cord-265941-eff4le0g	450	7	evolved	evolve	VBN
cord-265941-eff4le0g	450	8	highly	highly	RB
cord-265941-eff4le0g	450	9	specific	specific	JJ
cord-265941-eff4le0g	450	10	mechanisms	mechanism	NNS
cord-265941-eff4le0g	450	11	to	to	IN
cord-265941-eff4le0g	450	12	either	either	CC
cord-265941-eff4le0g	450	13	directly	directly	RB
cord-265941-eff4le0g	450	14	or	or	CC
cord-265941-eff4le0g	450	15	indirectly	indirectly	RB
cord-265941-eff4le0g	450	16	target	target	VB
cord-265941-eff4le0g	450	17	RIPK	RIPK	NNS
cord-265941-eff4le0g	450	18	signaling	signal	VBG
cord-265941-eff4le0g	450	19	networks	network	NNS
cord-265941-eff4le0g	450	20	to	to	TO
cord-265941-eff4le0g	450	21	benefit	benefit	VB
cord-265941-eff4le0g	450	22	replication	replication	NN
cord-265941-eff4le0g	450	23	and	and	CC
cord-265941-eff4le0g	450	24	survival	survival	NN
cord-265941-eff4le0g	450	25	,	,	,
cord-265941-eff4le0g	450	26	and	and	CC
cord-265941-eff4le0g	450	27	have	have	VBP
cord-265941-eff4le0g	450	28	thus	thus	RB
cord-265941-eff4le0g	450	29	provided	provide	VBN
cord-265941-eff4le0g	450	30	invaluable	invaluable	JJ
cord-265941-eff4le0g	450	31	knowledge	knowledge	NN
cord-265941-eff4le0g	450	32	on	on	IN
cord-265941-eff4le0g	450	33	the	the	DT
cord-265941-eff4le0g	450	34	physiological	physiological	JJ
cord-265941-eff4le0g	450	35	role	role	NN
cord-265941-eff4le0g	450	36	of	of	IN
cord-265941-eff4le0g	450	37	RIPK	RIPK	NNS
cord-265941-eff4le0g	450	38	signaling	signal	VBG
cord-265941-eff4le0g	450	39	in	in	IN
cord-265941-eff4le0g	450	40	the	the	DT
cord-265941-eff4le0g	450	41	context	context	NN
cord-265941-eff4le0g	450	42	of	of	IN
cord-265941-eff4le0g	450	43	infection	infection	NN
cord-265941-eff4le0g	450	44	.	.	.
cord-265941-eff4le0g	451	1	One	one	CD
cord-265941-eff4le0g	451	2	of	of	IN
cord-265941-eff4le0g	451	3	the	the	DT
cord-265941-eff4le0g	451	4	major	major	JJ
cord-265941-eff4le0g	451	5	challenges	challenge	NNS
cord-265941-eff4le0g	451	6	that	that	WDT
cord-265941-eff4le0g	451	7	remain	remain	VBP
cord-265941-eff4le0g	451	8	in	in	IN
cord-265941-eff4le0g	451	9	the	the	DT
cord-265941-eff4le0g	451	10	field	field	NN
cord-265941-eff4le0g	451	11	of	of	IN
cord-265941-eff4le0g	451	12	host	host	NN
cord-265941-eff4le0g	451	13	-	-	HYPH
cord-265941-eff4le0g	451	14	pathogen	pathogen	NN
cord-265941-eff4le0g	451	15	interactions	interaction	NNS
cord-265941-eff4le0g	451	16	is	be	VBZ
cord-265941-eff4le0g	451	17	the	the	DT
cord-265941-eff4le0g	451	18	consistency	consistency	NN
cord-265941-eff4le0g	451	19	of	of	IN
cord-265941-eff4le0g	451	20	experimental	experimental	JJ
cord-265941-eff4le0g	451	21	conditions	condition	NNS
cord-265941-eff4le0g	451	22	,	,	,
cord-265941-eff4le0g	451	23	whereby	whereby	WRB
cord-265941-eff4le0g	451	24	factors	factor	NNS
cord-265941-eff4le0g	451	25	including	include	VBG
cord-265941-eff4le0g	451	26	genetic	genetic	JJ
cord-265941-eff4le0g	451	27	background	background	NN
cord-265941-eff4le0g	451	28	of	of	IN
cord-265941-eff4le0g	451	29	animal	animal	NN
cord-265941-eff4le0g	451	30	models	model	NNS
cord-265941-eff4le0g	451	31	,	,	,
cord-265941-eff4le0g	451	32	specific	specific	JJ
cord-265941-eff4le0g	451	33	pathogen	pathogen	NN
cord-265941-eff4le0g	451	34	strains	strain	NNS
cord-265941-eff4le0g	451	35	(	(	-LRB-
cord-265941-eff4le0g	451	36	lab	lab	NN
cord-265941-eff4le0g	451	37	adapted	adapt	VBN
cord-265941-eff4le0g	451	38	vs	vs	IN
cord-265941-eff4le0g	451	39	currently	currently	RB
cord-265941-eff4le0g	451	40	circulating	circulate	VBG
cord-265941-eff4le0g	451	41	clinical	clinical	JJ
cord-265941-eff4le0g	451	42	isolates	isolate	NNS
cord-265941-eff4le0g	451	43	)	)	-RRB-
cord-265941-eff4le0g	451	44	,	,	,
cord-265941-eff4le0g	451	45	cell	cell	NN
cord-265941-eff4le0g	451	46	types	type	NNS
cord-265941-eff4le0g	451	47	(	(	-LRB-
cord-265941-eff4le0g	451	48	primary	primary	JJ
cord-265941-eff4le0g	451	49	,	,	,
cord-265941-eff4le0g	451	50	site	site	NN
cord-265941-eff4le0g	451	51	specific	specific	JJ
cord-265941-eff4le0g	451	52	vs	vs	IN
cord-265941-eff4le0g	451	53	immortalised	immortalise	VBN
cord-265941-eff4le0g	451	54	carcinoma	carcinoma	NN
cord-265941-eff4le0g	451	55	cell	cell	NN
cord-265941-eff4le0g	451	56	lines	line	NNS
cord-265941-eff4le0g	451	57	)	)	-RRB-
cord-265941-eff4le0g	451	58	and	and	CC
cord-265941-eff4le0g	451	59	the	the	DT
cord-265941-eff4le0g	451	60	use	use	NN
cord-265941-eff4le0g	451	61	of	of	IN
cord-265941-eff4le0g	451	62	inhibitors	inhibitor	NNS
cord-265941-eff4le0g	451	63	(	(	-LRB-
cord-265941-eff4le0g	451	64	e.g.	e.g.	DT
cord-265941-eff4le0g	451	65	Nec-1	Nec-1	NNP
cord-265941-eff4le0g	451	66	vs	vs	IN
cord-265941-eff4le0g	451	67	Nec-1	Nec-1	NNP
cord-265941-eff4le0g	451	68	stable	stable	JJ
cord-265941-eff4le0g	451	69	)	)	-RRB-
cord-265941-eff4le0g	451	70	heavily	heavily	RB
cord-265941-eff4le0g	451	71	influence	influence	VBP
cord-265941-eff4le0g	451	72	experimental	experimental	JJ
cord-265941-eff4le0g	451	73	outcomes	outcome	NNS
cord-265941-eff4le0g	451	74	.	.	.
cord-265941-eff4le0g	452	1	The	the	DT
cord-265941-eff4le0g	452	2	more	more	RBR
cord-265941-eff4le0g	452	3	unified	unified	JJ
cord-265941-eff4le0g	452	4	this	this	DT
cord-265941-eff4le0g	452	5	becomes	become	VBZ
cord-265941-eff4le0g	452	6	globally	globally	RB
cord-265941-eff4le0g	452	7	,	,	,
cord-265941-eff4le0g	452	8	the	the	DT
cord-265941-eff4le0g	452	9	more	more	RBR
cord-265941-eff4le0g	452	10	reliable	reliable	JJ
cord-265941-eff4le0g	452	11	the	the	DT
cord-265941-eff4le0g	452	12	data	datum	NNS
cord-265941-eff4le0g	452	13	will	will	MD
cord-265941-eff4le0g	452	14	become	become	VB
cord-265941-eff4le0g	452	15	.	.	.
cord-265941-eff4le0g	453	1	Finally	finally	RB
cord-265941-eff4le0g	453	2	,	,	,
cord-265941-eff4le0g	453	3	RIPKs	ripks	PRP
cord-265941-eff4le0g	453	4	are	be	VBP
cord-265941-eff4le0g	453	5	currently	currently	RB
cord-265941-eff4le0g	453	6	under	under	IN
cord-265941-eff4le0g	453	7	critical	critical	JJ
cord-265941-eff4le0g	453	8	review	review	NN
cord-265941-eff4le0g	453	9	as	as	IN
cord-265941-eff4le0g	453	10	potential	potential	JJ
cord-265941-eff4le0g	453	11	therapeutic	therapeutic	JJ
cord-265941-eff4le0g	453	12	targets	target	NNS
cord-265941-eff4le0g	453	13	,	,	,
cord-265941-eff4le0g	453	14	as	as	IN
cord-265941-eff4le0g	453	15	dysregulation	dysregulation	NN
cord-265941-eff4le0g	453	16	of	of	IN
cord-265941-eff4le0g	453	17	RIPK	RIPK	NNS
cord-265941-eff4le0g	453	18	signaling	signaling	NN
cord-265941-eff4le0g	453	19	is	be	VBZ
cord-265941-eff4le0g	453	20	closely	closely	RB
cord-265941-eff4le0g	453	21	associated	associate	VBN
cord-265941-eff4le0g	453	22	with	with	IN
cord-265941-eff4le0g	453	23	hyperinflammation	hyperinflammation	NN
cord-265941-eff4le0g	453	24	and	and	CC
cord-265941-eff4le0g	453	25	pathology	pathology	NN
cord-265941-eff4le0g	453	26	.	.	.
cord-265941-eff4le0g	454	1	Multiple	multiple	JJ
cord-265941-eff4le0g	454	2	studies	study	NNS
cord-265941-eff4le0g	454	3	are	be	VBP
cord-265941-eff4le0g	454	4	investigating	investigate	VBG
cord-265941-eff4le0g	454	5	various	various	JJ
cord-265941-eff4le0g	454	6	classes	class	NNS
cord-265941-eff4le0g	454	7	of	of	IN
cord-265941-eff4le0g	454	8	kinase	kinase	NN
cord-265941-eff4le0g	454	9	inhibitors	inhibitor	NNS
cord-265941-eff4le0g	454	10	for	for	IN
cord-265941-eff4le0g	454	11	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	454	12	-	-	HYPH
cord-265941-eff4le0g	454	13	3	3	CD
cord-265941-eff4le0g	454	14	[	[	-LRB-
cord-265941-eff4le0g	454	15	228	228	CD
cord-265941-eff4le0g	454	16	]	]	-RRB-
cord-265941-eff4le0g	454	17	,	,	,
cord-265941-eff4le0g	454	18	however	however	RB
cord-265941-eff4le0g	454	19	given	give	VBN
cord-265941-eff4le0g	454	20	the	the	DT
cord-265941-eff4le0g	454	21	importance	importance	NN
cord-265941-eff4le0g	454	22	of	of	IN
cord-265941-eff4le0g	454	23	kinase	kinase	NN
cord-265941-eff4le0g	454	24	-	-	HYPH
cord-265941-eff4le0g	454	25	dependent	dependent	JJ
cord-265941-eff4le0g	454	26	cell	cell	NN
cord-265941-eff4le0g	454	27	-	-	HYPH
cord-265941-eff4le0g	454	28	death	death	NN
cord-265941-eff4le0g	454	29	responses	response	NNS
cord-265941-eff4le0g	454	30	to	to	IN
cord-265941-eff4le0g	454	31	infection	infection	NN
cord-265941-eff4le0g	454	32	,	,	,
cord-265941-eff4le0g	454	33	it	-PRON-	PRP
cord-265941-eff4le0g	454	34	is	be	VBZ
cord-265941-eff4le0g	454	35	critical	critical	JJ
cord-265941-eff4le0g	454	36	that	that	IN
cord-265941-eff4le0g	454	37	we	-PRON-	PRP
cord-265941-eff4le0g	454	38	understand	understand	VBP
cord-265941-eff4le0g	454	39	the	the	DT
cord-265941-eff4le0g	454	40	impact	impact	NN
cord-265941-eff4le0g	454	41	of	of	IN
cord-265941-eff4le0g	454	42	these	these	DT
cord-265941-eff4le0g	454	43	therapeutic	therapeutic	JJ
cord-265941-eff4le0g	454	44	interventions	intervention	NNS
cord-265941-eff4le0g	454	45	on	on	IN
cord-265941-eff4le0g	454	46	infection	infection	NN
cord-265941-eff4le0g	454	47	outcomes	outcome	NNS
cord-265941-eff4le0g	454	48	before	before	IN
cord-265941-eff4le0g	454	49	introduction	introduction	NN
cord-265941-eff4le0g	454	50	to	to	IN
cord-265941-eff4le0g	454	51	the	the	DT
cord-265941-eff4le0g	454	52	clinic	clinic	NN
cord-265941-eff4le0g	454	53	.	.	.
cord-265941-eff4le0g	455	1	The	the	DT
cord-265941-eff4le0g	455	2	same	same	JJ
cord-265941-eff4le0g	455	3	goes	go	VBZ
cord-265941-eff4le0g	455	4	for	for	IN
cord-265941-eff4le0g	455	5	the	the	DT
cord-265941-eff4le0g	455	6	recently	recently	RB
cord-265941-eff4le0g	455	7	identified	identify	VBN
cord-265941-eff4le0g	455	8	small	small	JJ
cord-265941-eff4le0g	455	9	molecule	molecule	NN
cord-265941-eff4le0g	455	10	therapy	therapy	NN
cord-265941-eff4le0g	455	11	,	,	,
cord-265941-eff4le0g	455	12	Proteolysis	Proteolysis	NNP
cord-265941-eff4le0g	455	13	-	-	HYPH
cord-265941-eff4le0g	455	14	Targeting	target	VBG
cord-265941-eff4le0g	455	15	Chimeras	chimera	NNS
cord-265941-eff4le0g	455	16	(	(	-LRB-
cord-265941-eff4le0g	455	17	PROTACs	protac	NNS
cord-265941-eff4le0g	455	18	)	)	-RRB-
cord-265941-eff4le0g	455	19	,	,	,
cord-265941-eff4le0g	455	20	for	for	IN
cord-265941-eff4le0g	455	21	the	the	DT
cord-265941-eff4le0g	455	22	selective	selective	JJ
cord-265941-eff4le0g	455	23	degradation	degradation	NN
cord-265941-eff4le0g	455	24	of	of	IN
cord-265941-eff4le0g	455	25	RIPK2	ripk2	DT
cord-265941-eff4le0g	455	26	[	[	-LRB-
cord-265941-eff4le0g	455	27	229	229	CD
cord-265941-eff4le0g	455	28	]	]	-RRB-
cord-265941-eff4le0g	455	29	;	;	:
cord-265941-eff4le0g	455	30	given	give	VBN
cord-265941-eff4le0g	455	31	the	the	DT
cord-265941-eff4le0g	455	32	importance	importance	NN
cord-265941-eff4le0g	455	33	of	of	IN
cord-265941-eff4le0g	455	34	RIPK2	ripk2	NN
cord-265941-eff4le0g	455	35	in	in	IN
cord-265941-eff4le0g	455	36	detection	detection	NN
cord-265941-eff4le0g	455	37	of	of	IN
cord-265941-eff4le0g	455	38	multiple	multiple	JJ
cord-265941-eff4le0g	455	39	intracellular	intracellular	JJ
cord-265941-eff4le0g	455	40	pathogens	pathogen	NNS
cord-265941-eff4le0g	455	41	,	,	,
cord-265941-eff4le0g	455	42	what	what	WP
cord-265941-eff4le0g	455	43	would	would	MD
cord-265941-eff4le0g	455	44	be	be	VB
cord-265941-eff4le0g	455	45	the	the	DT
cord-265941-eff4le0g	455	46	effect	effect	NN
cord-265941-eff4le0g	455	47	on	on	IN
cord-265941-eff4le0g	455	48	infection	infection	NN
cord-265941-eff4le0g	455	49	outcome	outcome	NN
cord-265941-eff4le0g	455	50	?	?	.
cord-265941-eff4le0g	456	1	Overall	overall	RB
cord-265941-eff4le0g	456	2	,	,	,
cord-265941-eff4le0g	456	3	there	there	EX
cord-265941-eff4le0g	456	4	has	have	VBZ
cord-265941-eff4le0g	456	5	been	be	VBN
cord-265941-eff4le0g	456	6	significant	significant	JJ
cord-265941-eff4le0g	456	7	progress	progress	NN
cord-265941-eff4le0g	456	8	made	make	VBN
cord-265941-eff4le0g	456	9	in	in	IN
cord-265941-eff4le0g	456	10	the	the	DT
cord-265941-eff4le0g	456	11	field	field	NN
cord-265941-eff4le0g	456	12	of	of	IN
cord-265941-eff4le0g	456	13	RIPK	RIPK	NNP
cord-265941-eff4le0g	456	14	biology	biology	NN
cord-265941-eff4le0g	456	15	,	,	,
cord-265941-eff4le0g	456	16	and	and	CC
cord-265941-eff4le0g	456	17	continued	continue	VBN
cord-265941-eff4le0g	456	18	efforts	effort	NNS
cord-265941-eff4le0g	456	19	on	on	IN
cord-265941-eff4le0g	456	20	this	this	DT
cord-265941-eff4le0g	456	21	front	front	NN
cord-265941-eff4le0g	456	22	will	will	MD
cord-265941-eff4le0g	456	23	help	help	VB
cord-265941-eff4le0g	456	24	to	to	TO
cord-265941-eff4le0g	456	25	bolster	bolster	VB
cord-265941-eff4le0g	456	26	our	-PRON-	PRP$
cord-265941-eff4le0g	456	27	understanding	understanding	NN
cord-265941-eff4le0g	456	28	of	of	IN
cord-265941-eff4le0g	456	29	host	host	NN
cord-265941-eff4le0g	456	30	-	-	HYPH
cord-265941-eff4le0g	456	31	pathogen	pathogen	NN
cord-265941-eff4le0g	456	32	interactions	interaction	NNS
cord-265941-eff4le0g	456	33	and	and	CC
cord-265941-eff4le0g	456	34	potential	potential	JJ
cord-265941-eff4le0g	456	35	therapeutic	therapeutic	JJ
cord-265941-eff4le0g	456	36	development	development	NN
cord-265941-eff4le0g	456	37	for	for	IN
cord-265941-eff4le0g	456	38	infectious	infectious	JJ
cord-265941-eff4le0g	456	39	diseases	disease	NNS
cord-265941-eff4le0g	456	40	.	.	.
cord-265941-eff4le0g	457	1	To	to	IN
cord-265941-eff4le0g	457	2	this	this	DT
cord-265941-eff4le0g	457	3	end	end	NN
cord-265941-eff4le0g	457	4	,	,	,
cord-265941-eff4le0g	457	5	we	-PRON-	PRP
cord-265941-eff4le0g	457	6	must	must	MD
cord-265941-eff4le0g	457	7	continue	continue	VB
cord-265941-eff4le0g	457	8	to	to	TO
cord-265941-eff4le0g	457	9	develop	develop	VB
cord-265941-eff4le0g	457	10	a	a	DT
cord-265941-eff4le0g	457	11	comprehensive	comprehensive	JJ
cord-265941-eff4le0g	457	12	understanding	understanding	NN
cord-265941-eff4le0g	457	13	the	the	DT
cord-265941-eff4le0g	457	14	of	of	IN
cord-265941-eff4le0g	457	15	1	1	CD
cord-265941-eff4le0g	457	16	)	)	-RRB-
cord-265941-eff4le0g	458	1	the	the	DT
cord-265941-eff4le0g	458	2	biochemical	biochemical	JJ
cord-265941-eff4le0g	458	3	function	function	NN
cord-265941-eff4le0g	458	4	of	of	IN
cord-265941-eff4le0g	458	5	each	each	DT
cord-265941-eff4le0g	458	6	RIPK	RIPK	NNP
cord-265941-eff4le0g	458	7	domain	domain	NN
cord-265941-eff4le0g	458	8	and	and	CC
cord-265941-eff4le0g	458	9	the	the	DT
cord-265941-eff4le0g	458	10	role	role	NN
cord-265941-eff4le0g	458	11	they	-PRON-	PRP
cord-265941-eff4le0g	458	12	play	play	VBP
cord-265941-eff4le0g	458	13	in	in	IN
cord-265941-eff4le0g	458	14	response	response	NN
cord-265941-eff4le0g	458	15	to	to	IN
cord-265941-eff4le0g	458	16	specific	specific	JJ
cord-265941-eff4le0g	458	17	pathogens	pathogen	NNS
cord-265941-eff4le0g	458	18	,	,	,
cord-265941-eff4le0g	458	19	and	and	CC
cord-265941-eff4le0g	458	20	2	2	LS
cord-265941-eff4le0g	458	21	)	)	-RRB-
cord-265941-eff4le0g	458	22	biochemical	biochemical	JJ
cord-265941-eff4le0g	458	23	mechanisms	mechanism	NNS
cord-265941-eff4le0g	458	24	of	of	IN
cord-265941-eff4le0g	458	25	virulence	virulence	NN
cord-265941-eff4le0g	458	26	factors	factor	NNS
cord-265941-eff4le0g	458	27	in	in	IN
cord-265941-eff4le0g	458	28	currently	currently	RB
cord-265941-eff4le0g	458	29	circulating	circulate	VBG
cord-265941-eff4le0g	458	30	pathogenic	pathogenic	JJ
cord-265941-eff4le0g	458	31	organisms	organism	NNS
cord-265941-eff4le0g	458	32	.	.	.
cord-265941-eff4le0g	459	1	We	-PRON-	PRP
cord-265941-eff4le0g	459	2	,	,	,
cord-265941-eff4le0g	459	3	the	the	DT
cord-265941-eff4le0g	459	4	authors	author	NNS
cord-265941-eff4le0g	459	5	declare	declare	VBP
cord-265941-eff4le0g	459	6	no	no	DT
cord-265941-eff4le0g	459	7	competing	compete	VBG
cord-265941-eff4le0g	459	8	interests	interest	NNS
cord-265941-eff4le0g	459	9	.	.	.
cord-265941-eff4le0g	459	10	 	 	_SP
cord-265941-eff4le0g	460	1	Pattern	pattern	NN
cord-265941-eff4le0g	460	2	recognition	recognition	NN
cord-265941-eff4le0g	460	3	receptors	receptor	NNS
cord-265941-eff4le0g	460	4	and	and	CC
cord-265941-eff4le0g	460	5	inflammation	inflammation	NN
cord-265941-eff4le0g	460	6	RIP	rip	NN
cord-265941-eff4le0g	460	7	kinases	kinase	NNS
cord-265941-eff4le0g	460	8	as	as	IN
cord-265941-eff4le0g	460	9	modulators	modulator	NNS
cord-265941-eff4le0g	460	10	of	of	IN
cord-265941-eff4le0g	460	11	inflammation	inflammation	NN
cord-265941-eff4le0g	460	12	and	and	CC
cord-265941-eff4le0g	460	13	immunity	immunity	NN
cord-265941-eff4le0g	460	14	Inhibition	inhibition	NN
cord-265941-eff4le0g	460	15	of	of	IN
cord-265941-eff4le0g	460	16	RIP2	RIP2	NNP
cord-265941-eff4le0g	460	17	's	's	POS
cord-265941-eff4le0g	460	18	tyrosine	tyrosine	NN
cord-265941-eff4le0g	460	19	kinase	kinase	NN
cord-265941-eff4le0g	460	20	activity	activity	NN
cord-265941-eff4le0g	460	21	limits	limit	VBZ
cord-265941-eff4le0g	460	22	NOD2-driven	NOD2-driven	NNP
cord-265941-eff4le0g	460	23	cytokine	cytokine	NN
cord-265941-eff4le0g	460	24	responses	response	NNS
cord-265941-eff4le0g	461	1	The	the	DT
cord-265941-eff4le0g	461	2	death	death	NN
cord-265941-eff4le0g	461	3	domain	domain	NN
cord-265941-eff4le0g	461	4	kinase	kinase	NN
cord-265941-eff4le0g	461	5	RIP	RIP	NNP
cord-265941-eff4le0g	461	6	mediates	mediate	VBZ
cord-265941-eff4le0g	461	7	the	the	DT
cord-265941-eff4le0g	461	8	TNF	TNF	NNP
cord-265941-eff4le0g	461	9	-	-	HYPH
cord-265941-eff4le0g	461	10	induced	induce	VBN
cord-265941-eff4le0g	461	11	NF	NF	NNP
cord-265941-eff4le0g	461	12	-	-	HYPH
cord-265941-eff4le0g	461	13	kappaB	kappaB	NNP
cord-265941-eff4le0g	461	14	signal	signal	NN
cord-265941-eff4le0g	462	1	The	the	DT
cord-265941-eff4le0g	462	2	death	death	NN
cord-265941-eff4le0g	462	3	domain	domain	NN
cord-265941-eff4le0g	462	4	kinase	kinase	NN
cord-265941-eff4le0g	462	5	RIP	RIP	NNP
cord-265941-eff4le0g	462	6	is	be	VBZ
cord-265941-eff4le0g	462	7	essential	essential	JJ
cord-265941-eff4le0g	462	8	for	for	IN
cord-265941-eff4le0g	462	9	TRAIL	TRAIL	NNP
cord-265941-eff4le0g	462	10	(	(	-LRB-
cord-265941-eff4le0g	462	11	Apo2L)-induced	apo2l)-induced	JJ
cord-265941-eff4le0g	462	12	activation	activation	NN
cord-265941-eff4le0g	462	13	of	of	IN
cord-265941-eff4le0g	462	14	IkappaB	IkappaB	NNP
cord-265941-eff4le0g	462	15	kinase	kinase	NN
cord-265941-eff4le0g	462	16	and	and	CC
cord-265941-eff4le0g	462	17	c	c	NN
cord-265941-eff4le0g	462	18	-	-	:
cord-265941-eff4le0g	462	19	Jun	Jun	NNP
cord-265941-eff4le0g	462	20	N	N	NNP
cord-265941-eff4le0g	462	21	-	-	HYPH
cord-265941-eff4le0g	462	22	terminal	terminal	NN
cord-265941-eff4le0g	462	23	kinase	kinase	NN
cord-265941-eff4le0g	462	24	RIP	rip	NN
cord-265941-eff4le0g	462	25	:	:	:
cord-265941-eff4le0g	462	26	a	a	DT
cord-265941-eff4le0g	462	27	novel	novel	JJ
cord-265941-eff4le0g	462	28	protein	protein	NN
cord-265941-eff4le0g	462	29	containing	contain	VBG
cord-265941-eff4le0g	462	30	a	a	DT
cord-265941-eff4le0g	462	31	death	death	NN
cord-265941-eff4le0g	462	32	domain	domain	NN
cord-265941-eff4le0g	462	33	that	that	WDT
cord-265941-eff4le0g	462	34	interacts	interact	VBZ
cord-265941-eff4le0g	462	35	with	with	IN
cord-265941-eff4le0g	462	36	Fas	Fas	NNP
cord-265941-eff4le0g	462	37	/	/	SYM
cord-265941-eff4le0g	462	38	APO-1	APO-1	NNP
cord-265941-eff4le0g	462	39	(	(	-LRB-
cord-265941-eff4le0g	462	40	CD95	CD95	NNP
cord-265941-eff4le0g	462	41	)	)	-RRB-
cord-265941-eff4le0g	462	42	in	in	IN
cord-265941-eff4le0g	462	43	yeast	yeast	NN
cord-265941-eff4le0g	462	44	and	and	CC
cord-265941-eff4le0g	462	45	causes	cause	VBZ
cord-265941-eff4le0g	462	46	cell	cell	NN
cord-265941-eff4le0g	462	47	death	death	NN
cord-265941-eff4le0g	462	48	Rip1	Rip1	NNP
cord-265941-eff4le0g	462	49	mediates	mediate	VBZ
cord-265941-eff4le0g	462	50	the	the	DT
cord-265941-eff4le0g	462	51	Trif	Trif	NNP
cord-265941-eff4le0g	462	52	-	-	HYPH
cord-265941-eff4le0g	462	53	dependent	dependent	JJ
cord-265941-eff4le0g	462	54	toll	toll	NN
cord-265941-eff4le0g	462	55	-	-	HYPH
cord-265941-eff4le0g	462	56	like	like	JJ
cord-265941-eff4le0g	462	57	receptor	receptor	NN
cord-265941-eff4le0g	462	58	3-and	3-and	CD
cord-265941-eff4le0g	462	59	4-induced	4-induced	CD
cord-265941-eff4le0g	462	60	NF	nf	NN
cord-265941-eff4le0g	462	61	-	-	HYPH
cord-265941-eff4le0g	462	62	κB	κb	CD
cord-265941-eff4le0g	462	63	activation	activation	NN
cord-265941-eff4le0g	462	64	but	but	CC
cord-265941-eff4le0g	462	65	does	do	VBZ
cord-265941-eff4le0g	462	66	not	not	RB
cord-265941-eff4le0g	462	67	contribute	contribute	VB
cord-265941-eff4le0g	462	68	to	to	IN
cord-265941-eff4le0g	462	69	interferon	interferon	NN
cord-265941-eff4le0g	462	70	regulatory	regulatory	JJ
cord-265941-eff4le0g	462	71	factor	factor	NN
cord-265941-eff4le0g	463	1	3	3	CD
cord-265941-eff4le0g	463	2	activation	activation	NN
cord-265941-eff4le0g	463	3	RIP1	RIP1	NNP
cord-265941-eff4le0g	463	4	is	be	VBZ
cord-265941-eff4le0g	463	5	an	an	DT
cord-265941-eff4le0g	463	6	essential	essential	JJ
cord-265941-eff4le0g	463	7	mediator	mediator	NN
cord-265941-eff4le0g	463	8	of	of	IN
cord-265941-eff4le0g	463	9	Toll	Toll	NNP
cord-265941-eff4le0g	463	10	-	-	HYPH
cord-265941-eff4le0g	463	11	like	like	JJ
cord-265941-eff4le0g	463	12	receptor	receptor	NN
cord-265941-eff4le0g	463	13	3-induced	3-induced	CD
cord-265941-eff4le0g	463	14	NFkappa	NFkappa	NNP
cord-265941-eff4le0g	463	15	B	B	NNP
cord-265941-eff4le0g	463	16	activation	activation	NN
cord-265941-eff4le0g	463	17	RIPK3	ripk3	NN
cord-265941-eff4le0g	463	18	in	in	IN
cord-265941-eff4le0g	463	19	cell	cell	NN
cord-265941-eff4le0g	463	20	death	death	NN
cord-265941-eff4le0g	463	21	and	and	CC
cord-265941-eff4le0g	463	22	inflammation	inflammation	NN
cord-265941-eff4le0g	463	23	:	:	:
cord-265941-eff4le0g	463	24	the	the	DT
cord-265941-eff4le0g	463	25	good	good	NN
cord-265941-eff4le0g	463	26	,	,	,
cord-265941-eff4le0g	463	27	the	the	DT
cord-265941-eff4le0g	463	28	bad	bad	JJ
cord-265941-eff4le0g	463	29	,	,	,
cord-265941-eff4le0g	463	30	and	and	CC
cord-265941-eff4le0g	463	31	the	the	DT
cord-265941-eff4le0g	463	32	ugly	ugly	JJ
cord-265941-eff4le0g	463	33	TRADD	TRADD	NNP
cord-265941-eff4le0g	463	34	-	-	HYPH
cord-265941-eff4le0g	463	35	TRAF2	TRAF2	NNP
cord-265941-eff4le0g	463	36	and	and	CC
cord-265941-eff4le0g	463	37	TRADD	TRADD	NNP
cord-265941-eff4le0g	463	38	-	-	HYPH
cord-265941-eff4le0g	463	39	FADD	FADD	NNP
cord-265941-eff4le0g	463	40	interactions	interaction	NNS
cord-265941-eff4le0g	463	41	define	define	VBP
cord-265941-eff4le0g	463	42	two	two	CD
cord-265941-eff4le0g	463	43	distinct	distinct	JJ
cord-265941-eff4le0g	463	44	TNF	TNF	NNP
cord-265941-eff4le0g	463	45	receptor	receptor	NN
cord-265941-eff4le0g	463	46	1	1	CD
cord-265941-eff4le0g	463	47	signal	signal	NN
cord-265941-eff4le0g	463	48	transduction	transduction	NN
cord-265941-eff4le0g	463	49	pathways	pathway	NNS
cord-265941-eff4le0g	463	50	Induction	Induction	NNP
cord-265941-eff4le0g	463	51	of	of	IN
cord-265941-eff4le0g	463	52	TNF	TNF	NNP
cord-265941-eff4le0g	463	53	receptor	receptor	NN
cord-265941-eff4le0g	464	1	I	-PRON-	PRP
cord-265941-eff4le0g	464	2	-	-	HYPH
cord-265941-eff4le0g	464	3	Mediated	mediate	VBN
cord-265941-eff4le0g	464	4	apoptosis	apoptosis	NN
cord-265941-eff4le0g	464	5	via	via	IN
cord-265941-eff4le0g	464	6	two	two	CD
cord-265941-eff4le0g	464	7	sequential	sequential	JJ
cord-265941-eff4le0g	464	8	signaling	signal	VBG
cord-265941-eff4le0g	464	9	complexes	complex	NNS
cord-265941-eff4le0g	465	1	The	the	DT
cord-265941-eff4le0g	465	2	role	role	NN
cord-265941-eff4le0g	465	3	of	of	IN
cord-265941-eff4le0g	465	4	the	the	DT
cord-265941-eff4le0g	465	5	death	death	NN
cord-265941-eff4le0g	465	6	-	-	HYPH
cord-265941-eff4le0g	465	7	domain	domain	NN
cord-265941-eff4le0g	465	8	kinase	kinase	NN
cord-265941-eff4le0g	465	9	RIP	rip	VBP
cord-265941-eff4le0g	465	10	in	in	IN
cord-265941-eff4le0g	465	11	tumournecrosis	tumournecrosis	NN
cord-265941-eff4le0g	465	12	-	-	HYPH
cord-265941-eff4le0g	465	13	factor	factor	NN
cord-265941-eff4le0g	465	14	-	-	HYPH
cord-265941-eff4le0g	465	15	induced	induce	VBN
cord-265941-eff4le0g	465	16	activation	activation	NN
cord-265941-eff4le0g	465	17	of	of	IN
cord-265941-eff4le0g	465	18	mitogen	mitogen	NN
cord-265941-eff4le0g	465	19	-	-	HYPH
cord-265941-eff4le0g	465	20	activated	activate	VBN
cord-265941-eff4le0g	465	21	protein	protein	NN
cord-265941-eff4le0g	465	22	kinases	kinase	NNS
cord-265941-eff4le0g	465	23	Activation	Activation	NNP
cord-265941-eff4le0g	465	24	of	of	IN
cord-265941-eff4le0g	465	25	IKK	IKK	NNP
cord-265941-eff4le0g	465	26	by	by	IN
cord-265941-eff4le0g	465	27	TNFalpha	TNFalpha	NNP
cord-265941-eff4le0g	465	28	requires	require	VBZ
cord-265941-eff4le0g	465	29	site	site	NN
cord-265941-eff4le0g	465	30	-	-	HYPH
cord-265941-eff4le0g	465	31	specific	specific	JJ
cord-265941-eff4le0g	465	32	ubiquitination	ubiquitination	NN
cord-265941-eff4le0g	465	33	of	of	IN
cord-265941-eff4le0g	465	34	RIP1	RIP1	NNP
cord-265941-eff4le0g	465	35	and	and	CC
cord-265941-eff4le0g	465	36	polyubiquitin	polyubiquitin	NNP
cord-265941-eff4le0g	465	37	binding	bind	VBG
cord-265941-eff4le0g	465	38	by	by	IN
cord-265941-eff4le0g	465	39	NEMO	NEMO	NNP
cord-265941-eff4le0g	465	40	Vucic	Vucic	NNP
cord-265941-eff4le0g	465	41	,	,	,
cord-265941-eff4le0g	465	42	c	c	NN
cord-265941-eff4le0g	465	43	-	-	:
cord-265941-eff4le0g	465	44	IAP1	IAP1	NNP
cord-265941-eff4le0g	465	45	and	and	CC
cord-265941-eff4le0g	465	46	c	c	NNP
cord-265941-eff4le0g	465	47	-	-	:
cord-265941-eff4le0g	465	48	IAP2	IAP2	NNP
cord-265941-eff4le0g	465	49	are	be	VBP
cord-265941-eff4le0g	465	50	critical	critical	JJ
cord-265941-eff4le0g	465	51	mediators	mediator	NNS
cord-265941-eff4le0g	465	52	of	of	IN
cord-265941-eff4le0g	465	53	tumor	tumor	NN
cord-265941-eff4le0g	465	54	necrosis	necrosis	NN
cord-265941-eff4le0g	465	55	factor	factor	NN
cord-265941-eff4le0g	465	56	alpha	alpha	NN
cord-265941-eff4le0g	465	57	(	(	-LRB-
cord-265941-eff4le0g	465	58	TNFalpha)-induced	TNFalpha)-induced	NNP
cord-265941-eff4le0g	465	59	NF	NF	NNP
cord-265941-eff4le0g	465	60	-	-	HYPH
cord-265941-eff4le0g	465	61	kappaB	kappaB	NNP
cord-265941-eff4le0g	465	62	activation	activation	NN
cord-265941-eff4le0g	465	63	Diverse	diverse	JJ
cord-265941-eff4le0g	465	64	ubiquitin	ubiquitin	NN
cord-265941-eff4le0g	465	65	linkages	linkage	NNS
cord-265941-eff4le0g	465	66	regulate	regulate	VBP
cord-265941-eff4le0g	465	67	RIP	rip	NN
cord-265941-eff4le0g	465	68	kinases	kinase	NNS
cord-265941-eff4le0g	465	69	-	-	HYPH
cord-265941-eff4le0g	465	70	mediated	mediate	VBN
cord-265941-eff4le0g	465	71	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	465	72	and	and	CC
cord-265941-eff4le0g	465	73	cell	cell	NN
cord-265941-eff4le0g	465	74	death	death	NN
cord-265941-eff4le0g	465	75	signaling	signal	VBG
cord-265941-eff4le0g	465	76	Peli1	peli1	NN
cord-265941-eff4le0g	465	77	facilitates	facilitate	VBZ
cord-265941-eff4le0g	465	78	TRIF	trif	NN
cord-265941-eff4le0g	465	79	-	-	HYPH
cord-265941-eff4le0g	465	80	dependent	dependent	JJ
cord-265941-eff4le0g	465	81	Toll	toll	NN
cord-265941-eff4le0g	465	82	-	-	HYPH
cord-265941-eff4le0g	465	83	like	like	JJ
cord-265941-eff4le0g	465	84	receptor	receptor	NN
cord-265941-eff4le0g	465	85	signaling	signal	VBG
cord-265941-eff4le0g	465	86	and	and	CC
cord-265941-eff4le0g	465	87	proinflammatory	proinflammatory	JJ
cord-265941-eff4le0g	465	88	cytokine	cytokine	NN
cord-265941-eff4le0g	465	89	production	production	NN
cord-265941-eff4le0g	465	90	Kinase	Kinase	NNP
cord-265941-eff4le0g	465	91	activities	activity	NNS
cord-265941-eff4le0g	465	92	of	of	IN
cord-265941-eff4le0g	465	93	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	465	94	and	and	CC
cord-265941-eff4le0g	465	95	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	466	1	can	can	MD
cord-265941-eff4le0g	466	2	direct	direct	VB
cord-265941-eff4le0g	466	3	IFN	IFN	NNP
cord-265941-eff4le0g	466	4	-	-	HYPH
cord-265941-eff4le0g	466	5	β	β	NNP
cord-265941-eff4le0g	466	6	synthesis	synthesis	NN
cord-265941-eff4le0g	466	7	induced	induce	VBN
cord-265941-eff4le0g	466	8	by	by	IN
cord-265941-eff4le0g	466	9	lipopolysaccharide	lipopolysaccharide	NN
cord-265941-eff4le0g	466	10	Differential	differential	JJ
cord-265941-eff4le0g	466	11	roles	role	NNS
cord-265941-eff4le0g	466	12	of	of	IN
cord-265941-eff4le0g	466	13	MDA5	MDA5	NNP
cord-265941-eff4le0g	466	14	and	and	CC
cord-265941-eff4le0g	466	15	RIG	rig	NN
cord-265941-eff4le0g	467	1	-I	-i	DT
cord-265941-eff4le0g	467	2	helicases	helicase	NNS
cord-265941-eff4le0g	467	3	in	in	IN
cord-265941-eff4le0g	467	4	the	the	DT
cord-265941-eff4le0g	467	5	recognition	recognition	NN
cord-265941-eff4le0g	467	6	of	of	IN
cord-265941-eff4le0g	467	7	RNA	RNA	NNP
cord-265941-eff4le0g	467	8	viruses	virus	NNS
cord-265941-eff4le0g	467	9	RIG	rig	NN
cord-265941-eff4le0g	467	10	-	-	:
cord-265941-eff4le0g	467	11	I	I	NNP
cord-265941-eff4le0g	467	12	RNA	RNA	NNP
cord-265941-eff4le0g	467	13	helicase	helicase	NN
cord-265941-eff4le0g	467	14	activation	activation	NN
cord-265941-eff4le0g	467	15	of	of	IN
cord-265941-eff4le0g	467	16	IRF3	IRF3	NNP
cord-265941-eff4le0g	467	17	transcription	transcription	NN
cord-265941-eff4le0g	467	18	factor	factor	NN
cord-265941-eff4le0g	467	19	is	be	VBZ
cord-265941-eff4le0g	467	20	negatively	negatively	RB
cord-265941-eff4le0g	467	21	regulated	regulate	VBN
cord-265941-eff4le0g	467	22	by	by	IN
cord-265941-eff4le0g	467	23	Caspase-8-Mediated	caspase-8-mediated	JJ
cord-265941-eff4le0g	467	24	cleavage	cleavage	NN
cord-265941-eff4le0g	467	25	of	of	IN
cord-265941-eff4le0g	467	26	the	the	DT
cord-265941-eff4le0g	467	27	RIP1	RIP1	NNP
cord-265941-eff4le0g	467	28	protein	protein	NN
cord-265941-eff4le0g	467	29	Identification	identification	NN
cord-265941-eff4le0g	467	30	and	and	CC
cord-265941-eff4le0g	467	31	characterization	characterization	NN
cord-265941-eff4le0g	467	32	of	of	IN
cord-265941-eff4le0g	467	33	MAVS	MAVS	NNPS
cord-265941-eff4le0g	467	34	,	,	,
cord-265941-eff4le0g	467	35	a	a	DT
cord-265941-eff4le0g	467	36	mitochondrial	mitochondrial	JJ
cord-265941-eff4le0g	467	37	antiviral	antiviral	JJ
cord-265941-eff4le0g	467	38	signaling	signal	VBG
cord-265941-eff4le0g	467	39	protein	protein	NN
cord-265941-eff4le0g	467	40	that	that	WDT
cord-265941-eff4le0g	467	41	activates	activate	VBZ
cord-265941-eff4le0g	467	42	NF	NF	NNP
cord-265941-eff4le0g	467	43	-	-	HYPH
cord-265941-eff4le0g	467	44	kappaB	kappaB	NNP
cord-265941-eff4le0g	467	45	and	and	CC
cord-265941-eff4le0g	467	46	IRF	IRF	NNP
cord-265941-eff4le0g	467	47	3	3	CD
cord-265941-eff4le0g	467	48	Receptor	receptor	NN
cord-265941-eff4le0g	467	49	-	-	HYPH
cord-265941-eff4le0g	467	50	interacting	interact	VBG
cord-265941-eff4le0g	467	51	protein	protein	JJ
cord-265941-eff4le0g	467	52	homotypic	homotypic	JJ
cord-265941-eff4le0g	467	53	interaction	interaction	NN
cord-265941-eff4le0g	467	54	motif	motif	NN
cord-265941-eff4le0g	467	55	-	-	HYPH
cord-265941-eff4le0g	467	56	dependent	dependent	JJ
cord-265941-eff4le0g	467	57	control	control	NN
cord-265941-eff4le0g	467	58	of	of	IN
cord-265941-eff4le0g	467	59	NF	nf	NN
cord-265941-eff4le0g	467	60	-	-	HYPH
cord-265941-eff4le0g	467	61	kappa	kappa	NNP
cord-265941-eff4le0g	467	62	B	B	NNP
cord-265941-eff4le0g	467	63	activation	activation	NN
cord-265941-eff4le0g	467	64	via	via	IN
cord-265941-eff4le0g	467	65	the	the	DT
cord-265941-eff4le0g	467	66	DNAdependent	dnadependent	NN
cord-265941-eff4le0g	467	67	activator	activator	NN
cord-265941-eff4le0g	467	68	of	of	IN
cord-265941-eff4le0g	467	69	IFN	IFN	NNP
cord-265941-eff4le0g	467	70	regulatory	regulatory	JJ
cord-265941-eff4le0g	467	71	factors	factor	NNS
cord-265941-eff4le0g	468	1	DAI	DAI	NNP
cord-265941-eff4le0g	468	2	/	/	SYM
cord-265941-eff4le0g	468	3	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	468	4	recruits	recruit	VBZ
cord-265941-eff4le0g	468	5	RIP1	RIP1	NNP
cord-265941-eff4le0g	468	6	and	and	CC
cord-265941-eff4le0g	468	7	RIP3	RIP3	NNPS
cord-265941-eff4le0g	468	8	through	through	IN
cord-265941-eff4le0g	468	9	RIP	rip	JJ
cord-265941-eff4le0g	468	10	homotypic	homotypic	JJ
cord-265941-eff4le0g	468	11	interaction	interaction	NN
cord-265941-eff4le0g	468	12	motifs	motif	NNS
cord-265941-eff4le0g	468	13	to	to	TO
cord-265941-eff4le0g	468	14	activate	activate	VB
cord-265941-eff4le0g	468	15	NF	NF	NNP
cord-265941-eff4le0g	468	16	-	-	HYPH
cord-265941-eff4le0g	468	17	kappaB	kappaB	NNP
cord-265941-eff4le0g	468	18	Molecular	Molecular	NNP
cord-265941-eff4le0g	468	19	mechanisms	mechanism	NNS
cord-265941-eff4le0g	468	20	of	of	IN
cord-265941-eff4le0g	468	21	neuroinflammation	neuroinflammation	NN
cord-265941-eff4le0g	468	22	and	and	CC
cord-265941-eff4le0g	468	23	injury	injury	NN
cord-265941-eff4le0g	468	24	during	during	IN
cord-265941-eff4le0g	468	25	acute	acute	JJ
cord-265941-eff4le0g	468	26	viral	viral	JJ
cord-265941-eff4le0g	468	27	encephalitis	encephalitis	NN
cord-265941-eff4le0g	468	28	Zika	Zika	NNP
cord-265941-eff4le0g	468	29	Virus	Virus	NNP
cord-265941-eff4le0g	468	30	Pathogenesis	Pathogenesis	NNP
cord-265941-eff4le0g	468	31	:	:	:
cord-265941-eff4le0g	468	32	from	from	IN
cord-265941-eff4le0g	468	33	early	early	JJ
cord-265941-eff4le0g	468	34	case	case	NN
cord-265941-eff4le0g	468	35	reports	report	NNS
cord-265941-eff4le0g	468	36	to	to	IN
cord-265941-eff4le0g	468	37	epidemics	epidemic	NNS
cord-265941-eff4le0g	468	38	RIPK3	ripk3	NN
cord-265941-eff4le0g	468	39	restricts	restrict	VBZ
cord-265941-eff4le0g	468	40	viral	viral	JJ
cord-265941-eff4le0g	468	41	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	468	42	via	via	IN
cord-265941-eff4le0g	468	43	cell	cell	NN
cord-265941-eff4le0g	468	44	death	death	NN
cord-265941-eff4le0g	468	45	-	-	HYPH
cord-265941-eff4le0g	468	46	independent	independent	JJ
cord-265941-eff4le0g	468	47	neuroinflammation	neuroinflammation	NN
cord-265941-eff4le0g	469	1	The	the	DT
cord-265941-eff4le0g	469	2	nucleotide	nucleotide	JJ
cord-265941-eff4le0g	469	3	sensor	sensor	NN
cord-265941-eff4le0g	469	4	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	469	5	and	and	CC
cord-265941-eff4le0g	469	6	kinase	kinase	NN
cord-265941-eff4le0g	469	7	RIPK3	RIPK3	NNS
cord-265941-eff4le0g	469	8	induce	induce	VBP
cord-265941-eff4le0g	469	9	the	the	DT
cord-265941-eff4le0g	469	10	enzyme	enzyme	NN
cord-265941-eff4le0g	469	11	IRG1	IRG1	NNP
cord-265941-eff4le0g	469	12	to	to	TO
cord-265941-eff4le0g	469	13	promote	promote	VB
cord-265941-eff4le0g	469	14	an	an	DT
cord-265941-eff4le0g	469	15	antiviral	antiviral	JJ
cord-265941-eff4le0g	469	16	metabolic	metabolic	JJ
cord-265941-eff4le0g	469	17	state	state	NN
cord-265941-eff4le0g	469	18	in	in	IN
cord-265941-eff4le0g	469	19	neurons	neuron	NNS
cord-265941-eff4le0g	470	1	Krebs	Krebs	NNP
cord-265941-eff4le0g	470	2	cycle	cycle	NN
cord-265941-eff4le0g	470	3	reimagined	reimagine	VBN
cord-265941-eff4le0g	470	4	:	:	:
cord-265941-eff4le0g	471	1	the	the	DT
cord-265941-eff4le0g	471	2	emerging	emerge	VBG
cord-265941-eff4le0g	471	3	roles	role	NNS
cord-265941-eff4le0g	471	4	of	of	IN
cord-265941-eff4le0g	471	5	succinate	succinate	NN
cord-265941-eff4le0g	471	6	and	and	CC
cord-265941-eff4le0g	471	7	itaconate	itaconate	NNP
cord-265941-eff4le0g	471	8	as	as	IN
cord-265941-eff4le0g	471	9	signal	signal	NN
cord-265941-eff4le0g	471	10	transducers	transducer	NNS
cord-265941-eff4le0g	471	11	Differential	differential	JJ
cord-265941-eff4le0g	471	12	innate	innate	JJ
cord-265941-eff4le0g	471	13	immune	immune	JJ
cord-265941-eff4le0g	471	14	response	response	NN
cord-265941-eff4le0g	471	15	programs	program	NNS
cord-265941-eff4le0g	471	16	in	in	IN
cord-265941-eff4le0g	471	17	neuronal	neuronal	JJ
cord-265941-eff4le0g	471	18	subtypes	subtype	NNS
cord-265941-eff4le0g	471	19	determine	determine	VBP
cord-265941-eff4le0g	471	20	susceptibility	susceptibility	NN
cord-265941-eff4le0g	471	21	to	to	IN
cord-265941-eff4le0g	471	22	infection	infection	NN
cord-265941-eff4le0g	471	23	in	in	IN
cord-265941-eff4le0g	471	24	the	the	DT
cord-265941-eff4le0g	471	25	brain	brain	NN
cord-265941-eff4le0g	471	26	by	by	IN
cord-265941-eff4le0g	471	27	positive	positive	JJ
cord-265941-eff4le0g	471	28	-	-	HYPH
cord-265941-eff4le0g	471	29	stranded	strand	VBN
cord-265941-eff4le0g	471	30	RNA	RNA	NNP
cord-265941-eff4le0g	471	31	viruses	virus	NNS
cord-265941-eff4le0g	471	32	Inhibition	inhibition	NN
cord-265941-eff4le0g	471	33	of	of	IN
cord-265941-eff4le0g	471	34	proinflammatory	proinflammatory	JJ
cord-265941-eff4le0g	471	35	and	and	CC
cord-265941-eff4le0g	471	36	innate	innate	JJ
cord-265941-eff4le0g	471	37	immune	immune	JJ
cord-265941-eff4le0g	471	38	signaling	signal	VBG
cord-265941-eff4le0g	471	39	pathways	pathway	NNS
cord-265941-eff4le0g	471	40	by	by	IN
cord-265941-eff4le0g	471	41	a	a	DT
cord-265941-eff4le0g	471	42	cytomegalovirus	cytomegalovirus	JJ
cord-265941-eff4le0g	471	43	RIP1-interacting	rip1-interacting	NN
cord-265941-eff4le0g	471	44	protein	protein	NN
cord-265941-eff4le0g	471	45	Cooperative	cooperative	JJ
cord-265941-eff4le0g	471	46	inhibition	inhibition	NN
cord-265941-eff4le0g	471	47	of	of	IN
cord-265941-eff4le0g	471	48	RIP1-mediated	rip1-mediated	JJ
cord-265941-eff4le0g	471	49	NF	NF	NNP
cord-265941-eff4le0g	471	50	-	-	HYPH
cord-265941-eff4le0g	471	51	κB	κB	NNP
cord-265941-eff4le0g	471	52	signaling	signal	VBG
cord-265941-eff4le0g	471	53	by	by	IN
cord-265941-eff4le0g	471	54	cytomegalovirus	cytomegalovirus	NN
cord-265941-eff4le0g	471	55	-	-	HYPH
cord-265941-eff4le0g	471	56	encoded	encode	VBN
cord-265941-eff4le0g	471	57	deubiquitinase	deubiquitinase	NN
cord-265941-eff4le0g	471	58	and	and	CC
cord-265941-eff4le0g	471	59	inactive	inactive	JJ
cord-265941-eff4le0g	471	60	homolog	homolog	NN
cord-265941-eff4le0g	471	61	of	of	IN
cord-265941-eff4le0g	471	62	cellular	cellular	JJ
cord-265941-eff4le0g	471	63	ribonucleotide	ribonucleotide	NN
cord-265941-eff4le0g	471	64	reductase	reductase	NN
cord-265941-eff4le0g	471	65	large	large	JJ
cord-265941-eff4le0g	471	66	subunit	subunit	NN
cord-265941-eff4le0g	471	67	Cleavage	cleavage	NN
cord-265941-eff4le0g	471	68	specificity	specificity	NN
cord-265941-eff4le0g	471	69	of	of	IN
cord-265941-eff4le0g	471	70	the	the	DT
cord-265941-eff4le0g	471	71	UL48	UL48	NNP
cord-265941-eff4le0g	471	72	deubiquitinating	deubiquitinating	NN
cord-265941-eff4le0g	471	73	protease	protease	NN
cord-265941-eff4le0g	471	74	activity	activity	NN
cord-265941-eff4le0g	471	75	of	of	IN
cord-265941-eff4le0g	471	76	human	human	JJ
cord-265941-eff4le0g	471	77	cytomegalovirus	cytomegalovirus	NN
cord-265941-eff4le0g	471	78	and	and	CC
cord-265941-eff4le0g	471	79	the	the	DT
cord-265941-eff4le0g	471	80	growth	growth	NN
cord-265941-eff4le0g	471	81	of	of	IN
cord-265941-eff4le0g	471	82	an	an	DT
cord-265941-eff4le0g	471	83	active	active	JJ
cord-265941-eff4le0g	471	84	-	-	HYPH
cord-265941-eff4le0g	471	85	site	site	NN
cord-265941-eff4le0g	471	86	mutant	mutant	JJ
cord-265941-eff4le0g	471	87	virus	virus	NN
cord-265941-eff4le0g	471	88	in	in	IN
cord-265941-eff4le0g	471	89	cultured	cultured	JJ
cord-265941-eff4le0g	471	90	cells	cell	NNS
cord-265941-eff4le0g	472	1	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	472	2	promotes	promote	VBZ
cord-265941-eff4le0g	472	3	JEV	JEV	NNP
cord-265941-eff4le0g	472	4	replication	replication	NN
cord-265941-eff4le0g	472	5	in	in	IN
cord-265941-eff4le0g	472	6	neurons	neuron	NNS
cord-265941-eff4le0g	472	7	via	via	IN
cord-265941-eff4le0g	472	8	downregulation	downregulation	NN
cord-265941-eff4le0g	472	9	of	of	IN
cord-265941-eff4le0g	472	10	IFI44L	ifi44l	NN
cord-265941-eff4le0g	472	11	RIPK3	ripk3	XX
cord-265941-eff4le0g	473	1	interacts	interact	VBZ
cord-265941-eff4le0g	473	2	with	with	IN
cord-265941-eff4le0g	473	3	MAVS	MAVS	NNPS
cord-265941-eff4le0g	473	4	to	to	TO
cord-265941-eff4le0g	473	5	regulate	regulate	VB
cord-265941-eff4le0g	473	6	type	type	NN
cord-265941-eff4le0g	473	7	I	-PRON-	PRP
cord-265941-eff4le0g	473	8	IFN	IFN	NNP
cord-265941-eff4le0g	473	9	-	-	HYPH
cord-265941-eff4le0g	473	10	mediated	mediate	VBN
cord-265941-eff4le0g	473	11	immunity	immunity	NN
cord-265941-eff4le0g	473	12	to	to	IN
cord-265941-eff4le0g	473	13	Influenza	Influenza	NNP
cord-265941-eff4le0g	473	14	A	a	DT
cord-265941-eff4le0g	473	15	virus	virus	NN
cord-265941-eff4le0g	473	16	infection	infection	NN
cord-265941-eff4le0g	474	1	Protein	protein	NN
cord-265941-eff4le0g	474	2	kinase	kinase	NN
cord-265941-eff4le0g	474	3	R	r	NN
cord-265941-eff4le0g	474	4	contributes	contribute	VBZ
cord-265941-eff4le0g	474	5	to	to	IN
cord-265941-eff4le0g	474	6	immunity	immunity	NN
cord-265941-eff4le0g	474	7	against	against	IN
cord-265941-eff4le0g	474	8	specific	specific	JJ
cord-265941-eff4le0g	474	9	viruses	virus	NNS
cord-265941-eff4le0g	474	10	by	by	IN
cord-265941-eff4le0g	474	11	regulating	regulate	VBG
cord-265941-eff4le0g	475	1	interferon	interferon	NNP
cord-265941-eff4le0g	475	2	mRNA	mRNA	NNP
cord-265941-eff4le0g	475	3	integrity	integrity	NN
cord-265941-eff4le0g	475	4	Epstein	Epstein	NNP
cord-265941-eff4le0g	475	5	-	-	HYPH
cord-265941-eff4le0g	475	6	Barr	Barr	NNP
cord-265941-eff4le0g	475	7	virus	virus	NN
cord-265941-eff4le0g	475	8	encoded	encode	VBD
cord-265941-eff4le0g	475	9	latent	latent	JJ
cord-265941-eff4le0g	475	10	membrane	membrane	NN
cord-265941-eff4le0g	475	11	protein	protein	NN
cord-265941-eff4le0g	475	12	1	1	CD
cord-265941-eff4le0g	475	13	suppresses	suppress	VBZ
cord-265941-eff4le0g	475	14	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	475	15	through	through	IN
cord-265941-eff4le0g	475	16	targeting	target	VBG
cord-265941-eff4le0g	475	17	RIPK1/3	RIPK1/3	NNP
cord-265941-eff4le0g	475	18	ubiquitination	ubiquitination	IN
cord-265941-eff4le0g	475	19	Autophagy	Autophagy	NNP
cord-265941-eff4le0g	475	20	during	during	IN
cord-265941-eff4le0g	475	21	viral	viral	JJ
cord-265941-eff4le0g	475	22	infection	infection	NN
cord-265941-eff4le0g	475	23	-a	-a	HYPH
cord-265941-eff4le0g	475	24	doubleedged	doubleedged	JJ
cord-265941-eff4le0g	475	25	sword	sword	NN
cord-265941-eff4le0g	475	26	RIP3	RIP3	NNP
cord-265941-eff4le0g	475	27	regulates	regulate	VBZ
cord-265941-eff4le0g	475	28	autophagy	autophagy	NN
cord-265941-eff4le0g	475	29	and	and	CC
cord-265941-eff4le0g	475	30	promotes	promote	VBZ
cord-265941-eff4le0g	475	31	coxsackievirus	coxsackievirus	NNP
cord-265941-eff4le0g	475	32	B3	b3	NN
cord-265941-eff4le0g	475	33	infection	infection	NN
cord-265941-eff4le0g	475	34	of	of	IN
cord-265941-eff4le0g	475	35	intestinal	intestinal	JJ
cord-265941-eff4le0g	475	36	epithelial	epithelial	JJ
cord-265941-eff4le0g	475	37	cells	cell	NNS
cord-265941-eff4le0g	475	38	Cell	cell	NN
cord-265941-eff4le0g	475	39	death	death	NN
cord-265941-eff4le0g	475	40	programs	program	NNS
cord-265941-eff4le0g	475	41	in	in	IN
cord-265941-eff4le0g	475	42	Yersinia	Yersinia	NNP
cord-265941-eff4le0g	475	43	immunity	immunity	NN
cord-265941-eff4le0g	475	44	and	and	CC
cord-265941-eff4le0g	475	45	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	475	46	Caspase-8	Caspase-8	NNP
cord-265941-eff4le0g	475	47	and	and	CC
cord-265941-eff4le0g	475	48	RIP	rip	NN
cord-265941-eff4le0g	475	49	kinases	kinase	NNS
cord-265941-eff4le0g	475	50	regulate	regulate	VBP
cord-265941-eff4le0g	475	51	bacteria	bacteria	NNS
cord-265941-eff4le0g	475	52	-	-	HYPH
cord-265941-eff4le0g	475	53	induced	induce	VBN
cord-265941-eff4le0g	475	54	innate	innate	JJ
cord-265941-eff4le0g	475	55	immune	immune	JJ
cord-265941-eff4le0g	475	56	responses	response	NNS
cord-265941-eff4le0g	475	57	and	and	CC
cord-265941-eff4le0g	475	58	cell	cell	NN
cord-265941-eff4le0g	475	59	death	death	NN
cord-265941-eff4le0g	475	60	YopJ	YopJ	NNP
cord-265941-eff4le0g	475	61	family	family	NN
cord-265941-eff4le0g	475	62	effectors	effector	NNS
cord-265941-eff4le0g	475	63	promote	promote	VBP
cord-265941-eff4le0g	475	64	bacterial	bacterial	JJ
cord-265941-eff4le0g	475	65	infection	infection	NN
cord-265941-eff4le0g	475	66	through	through	IN
cord-265941-eff4le0g	475	67	a	a	DT
cord-265941-eff4le0g	475	68	unique	unique	JJ
cord-265941-eff4le0g	475	69	acetyltransferase	acetyltransferase	NN
cord-265941-eff4le0g	475	70	activity	activity	NN
cord-265941-eff4le0g	475	71	,	,	,
cord-265941-eff4le0g	475	72	Microbiol	Microbiol	NNP
cord-265941-eff4le0g	475	73	Molecular	Molecular	NNP
cord-265941-eff4le0g	475	74	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	475	75	of	of	IN
cord-265941-eff4le0g	475	76	infections	infection	NNS
cord-265941-eff4le0g	475	77	caused	cause	VBN
cord-265941-eff4le0g	475	78	by	by	IN
cord-265941-eff4le0g	475	79	Legionella	Legionella	NNP
cord-265941-eff4le0g	475	80	pneumophila	pneumophila	NN
cord-265941-eff4le0g	475	81	Discovery	Discovery	NNP
cord-265941-eff4le0g	475	82	of	of	IN
cord-265941-eff4le0g	475	83	ubiquitin	ubiquitin	NNP
cord-265941-eff4le0g	475	84	deamidases	deamidase	NNS
cord-265941-eff4le0g	475	85	in	in	IN
cord-265941-eff4le0g	475	86	the	the	DT
cord-265941-eff4le0g	475	87	pathogenic	pathogenic	JJ
cord-265941-eff4le0g	475	88	arsenal	arsenal	NN
cord-265941-eff4le0g	475	89	of	of	IN
cord-265941-eff4le0g	475	90	Legionella	Legionella	NNP
cord-265941-eff4le0g	475	91	pneumophila	pneumophila	NN
cord-265941-eff4le0g	475	92	Glutamine	Glutamine	NNP
cord-265941-eff4le0g	475	93	deamidation	deamidation	NN
cord-265941-eff4le0g	475	94	and	and	CC
cord-265941-eff4le0g	475	95	dysfunction	dysfunction	NN
cord-265941-eff4le0g	475	96	of	of	IN
cord-265941-eff4le0g	475	97	ubiquitin	ubiquitin	NNP
cord-265941-eff4le0g	475	98	/	/	SYM
cord-265941-eff4le0g	475	99	NEDD8	nedd8	NN
cord-265941-eff4le0g	475	100	induced	induce	VBN
cord-265941-eff4le0g	475	101	by	by	IN
cord-265941-eff4le0g	475	102	a	a	DT
cord-265941-eff4le0g	475	103	bacterial	bacterial	JJ
cord-265941-eff4le0g	475	104	effector	effector	NN
cord-265941-eff4le0g	475	105	family	family	NN
cord-265941-eff4le0g	475	106	Cycle	cycle	NN
cord-265941-eff4le0g	475	107	inhibiting	inhibit	VBG
cord-265941-eff4le0g	475	108	factors	factor	NNS
cord-265941-eff4le0g	475	109	(	(	-LRB-
cord-265941-eff4le0g	475	110	cifs	cifs	NN
cord-265941-eff4le0g	475	111	)	)	-RRB-
cord-265941-eff4le0g	475	112	:	:	:
cord-265941-eff4le0g	475	113	cyclomodulins	cyclomodulin	NNS
cord-265941-eff4le0g	475	114	that	that	WDT
cord-265941-eff4le0g	475	115	usurp	usurp	VBP
cord-265941-eff4le0g	475	116	the	the	DT
cord-265941-eff4le0g	475	117	ubiquitin	ubiquitin	NN
cord-265941-eff4le0g	475	118	-	-	HYPH
cord-265941-eff4le0g	475	119	dependent	dependent	JJ
cord-265941-eff4le0g	475	120	degradation	degradation	NN
cord-265941-eff4le0g	475	121	pathway	pathway	NN
cord-265941-eff4le0g	475	122	of	of	IN
cord-265941-eff4le0g	475	123	host	host	NN
cord-265941-eff4le0g	475	124	cells	cell	NNS
cord-265941-eff4le0g	475	125	Pathogen	Pathogen	NNP
cord-265941-eff4le0g	475	126	blocks	block	VBZ
cord-265941-eff4le0g	475	127	host	host	NN
cord-265941-eff4le0g	475	128	death	death	NN
cord-265941-eff4le0g	475	129	receptor	receptor	NN
cord-265941-eff4le0g	475	130	signalling	signal	VBG
cord-265941-eff4le0g	475	131	by	by	IN
cord-265941-eff4le0g	475	132	arginine	arginine	NN
cord-265941-eff4le0g	475	133	GlcNAcylation	glcnacylation	NN
cord-265941-eff4le0g	475	134	of	of	IN
cord-265941-eff4le0g	475	135	death	death	NN
cord-265941-eff4le0g	475	136	domains	domain	NNS
cord-265941-eff4le0g	476	1	A	a	DT
cord-265941-eff4le0g	476	2	type	type	NN
cord-265941-eff4le0g	476	3	III	iii	CD
cord-265941-eff4le0g	476	4	effector	effector	NN
cord-265941-eff4le0g	476	5	antagonizes	antagonize	VBZ
cord-265941-eff4le0g	476	6	death	death	NN
cord-265941-eff4le0g	476	7	receptor	receptor	NN
cord-265941-eff4le0g	476	8	signalling	signal	VBG
cord-265941-eff4le0g	476	9	during	during	IN
cord-265941-eff4le0g	476	10	bacterial	bacterial	JJ
cord-265941-eff4le0g	476	11	gut	gut	NN
cord-265941-eff4le0g	476	12	infection	infection	NN
cord-265941-eff4le0g	477	1	The	the	DT
cord-265941-eff4le0g	477	2	type	type	NN
cord-265941-eff4le0g	477	3	III	iii	CD
cord-265941-eff4le0g	477	4	effectors	effector	NNS
cord-265941-eff4le0g	477	5	NleE	NleE	NNP
cord-265941-eff4le0g	477	6	and	and	CC
cord-265941-eff4le0g	477	7	NleB	NleB	NNP
cord-265941-eff4le0g	477	8	from	from	IN
cord-265941-eff4le0g	477	9	enteropathogenic	enteropathogenic	JJ
cord-265941-eff4le0g	477	10	E.	E.	NNP
cord-265941-eff4le0g	477	11	Coli	Coli	NNP
cord-265941-eff4le0g	477	12	and	and	CC
cord-265941-eff4le0g	477	13	OspZ	OspZ	NNP
cord-265941-eff4le0g	477	14	from	from	IN
cord-265941-eff4le0g	477	15	Shigella	Shigella	NNP
cord-265941-eff4le0g	477	16	block	block	NN
cord-265941-eff4le0g	477	17	nuclear	nuclear	JJ
cord-265941-eff4le0g	477	18	translocation	translocation	NN
cord-265941-eff4le0g	477	19	of	of	IN
cord-265941-eff4le0g	477	20	NF	NF	NNP
cord-265941-eff4le0g	477	21	-	-	HYPH
cord-265941-eff4le0g	477	22	kappaB	kappaB	NNP
cord-265941-eff4le0g	477	23	p65	p65	NN
cord-265941-eff4le0g	477	24	A	a	DT
cord-265941-eff4le0g	477	25	type	type	NN
cord-265941-eff4le0g	477	26	III	iii	CD
cord-265941-eff4le0g	477	27	effector	effector	NN
cord-265941-eff4le0g	477	28	protease	protease	NN
cord-265941-eff4le0g	477	29	NleC	NleC	NNP
cord-265941-eff4le0g	477	30	from	from	IN
cord-265941-eff4le0g	477	31	enteropathogenic	enteropathogenic	JJ
cord-265941-eff4le0g	477	32	Escherichia	Escherichia	NNP
cord-265941-eff4le0g	477	33	coli	coli	NNS
cord-265941-eff4le0g	478	1	targets	target	NNS
cord-265941-eff4le0g	478	2	NF	NF	NNP
cord-265941-eff4le0g	478	3	-	-	HYPH
cord-265941-eff4le0g	478	4	κB	κB	NNP
cord-265941-eff4le0g	478	5	for	for	IN
cord-265941-eff4le0g	478	6	degradation	degradation	NN
cord-265941-eff4le0g	479	1	Apoptotic	apoptotic	JJ
cord-265941-eff4le0g	479	2	cell	cell	NN
cord-265941-eff4le0g	479	3	-	-	HYPH
cord-265941-eff4le0g	479	4	derived	derive	VBN
cord-265941-eff4le0g	479	5	extracellular	extracellular	JJ
cord-265941-eff4le0g	479	6	vesicles	vesicle	NNS
cord-265941-eff4le0g	479	7	:	:	:
cord-265941-eff4le0g	479	8	more	more	JJR
cord-265941-eff4le0g	479	9	than	than	IN
cord-265941-eff4le0g	479	10	just	just	RB
cord-265941-eff4le0g	479	11	debris	debris	NN
cord-265941-eff4le0g	480	1	The	the	DT
cord-265941-eff4le0g	480	2	tumour	tumour	NN
cord-265941-eff4le0g	480	3	suppressor	suppressor	NN
cord-265941-eff4le0g	480	4	CYLD	CYLD	NNP
cord-265941-eff4le0g	480	5	negatively	negatively	RB
cord-265941-eff4le0g	480	6	regulates	regulate	VBZ
cord-265941-eff4le0g	480	7	NF	nf	NN
cord-265941-eff4le0g	480	8	-	-	HYPH
cord-265941-eff4le0g	480	9	κB	κB	NNP
cord-265941-eff4le0g	480	10	signalling	signalling	NN
cord-265941-eff4le0g	480	11	by	by	IN
cord-265941-eff4le0g	480	12	deubiquitination	deubiquitination	NN
cord-265941-eff4le0g	480	13	Deubiquitination	Deubiquitination	NNP
cord-265941-eff4le0g	480	14	and	and	CC
cord-265941-eff4le0g	480	15	ubiquitin	ubiquitin	NN
cord-265941-eff4le0g	480	16	ligase	ligase	NN
cord-265941-eff4le0g	480	17	domains	domain	NNS
cord-265941-eff4le0g	480	18	of	of	IN
cord-265941-eff4le0g	480	19	A20	A20	NNP
cord-265941-eff4le0g	480	20	downregulate	downregulate	VBP
cord-265941-eff4le0g	480	21	NF	NF	NNP
cord-265941-eff4le0g	480	22	-	-	HYPH
cord-265941-eff4le0g	480	23	kappaB	kappaB	NNP
cord-265941-eff4le0g	480	24	signalling	signal	VBG
cord-265941-eff4le0g	480	25	Leverkus	Leverkus	NNP
cord-265941-eff4le0g	480	26	,	,	,
cord-265941-eff4le0g	480	27	cIAPs	cIAPs	NNP
cord-265941-eff4le0g	480	28	block	block	NN
cord-265941-eff4le0g	480	29	Ripoptosome	Ripoptosome	NNP
cord-265941-eff4le0g	480	30	formation	formation	NN
cord-265941-eff4le0g	480	31	,	,	,
cord-265941-eff4le0g	480	32	a	a	DT
cord-265941-eff4le0g	480	33	RIP1	RIP1	NNP
cord-265941-eff4le0g	480	34	/	/	SYM
cord-265941-eff4le0g	480	35	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	480	36	containing	contain	VBG
cord-265941-eff4le0g	480	37	intracellular	intracellular	JJ
cord-265941-eff4le0g	480	38	cell	cell	NN
cord-265941-eff4le0g	480	39	death	death	NN
cord-265941-eff4le0g	480	40	complex	complex	NN
cord-265941-eff4le0g	480	41	differentially	differentially	RB
cord-265941-eff4le0g	480	42	regulated	regulate	VBN
cord-265941-eff4le0g	480	43	by	by	IN
cord-265941-eff4le0g	480	44	cFLIP	cFLIP	NNP
cord-265941-eff4le0g	480	45	isoforms	isoform	NNS
cord-265941-eff4le0g	481	1	The	the	DT
cord-265941-eff4le0g	481	2	Ripoptosome	Ripoptosome	NNP
cord-265941-eff4le0g	481	3	,	,	,
cord-265941-eff4le0g	481	4	a	a	DT
cord-265941-eff4le0g	481	5	signaling	signal	VBG
cord-265941-eff4le0g	481	6	platform	platform	NN
cord-265941-eff4le0g	481	7	that	that	WDT
cord-265941-eff4le0g	481	8	assembles	assemble	VBZ
cord-265941-eff4le0g	481	9	in	in	IN
cord-265941-eff4le0g	481	10	response	response	NN
cord-265941-eff4le0g	481	11	to	to	IN
cord-265941-eff4le0g	481	12	genotoxic	genotoxic	JJ
cord-265941-eff4le0g	481	13	stress	stress	NN
cord-265941-eff4le0g	481	14	and	and	CC
cord-265941-eff4le0g	481	15	loss	loss	NN
cord-265941-eff4le0g	481	16	of	of	IN
cord-265941-eff4le0g	481	17	IAPs	iaps	NN
cord-265941-eff4le0g	481	18	RIPK3	ripk3	NN
cord-265941-eff4le0g	481	19	contributes	contribute	VBZ
cord-265941-eff4le0g	481	20	to	to	IN
cord-265941-eff4le0g	481	21	TNFR1-mediated	tnfr1-mediated	JJ
cord-265941-eff4le0g	481	22	RIPK1	ripk1	JJ
cord-265941-eff4le0g	481	23	kinase	kinase	NN
cord-265941-eff4le0g	481	24	-	-	HYPH
cord-265941-eff4le0g	481	25	dependent	dependent	JJ
cord-265941-eff4le0g	481	26	apoptosis	apoptosis	NN
cord-265941-eff4le0g	481	27	in	in	IN
cord-265941-eff4le0g	481	28	conditions	condition	NNS
cord-265941-eff4le0g	481	29	of	of	IN
cord-265941-eff4le0g	481	30	cIAP1/2	ciap1/2	CD
cord-265941-eff4le0g	481	31	depletion	depletion	NN
cord-265941-eff4le0g	481	32	or	or	CC
cord-265941-eff4le0g	481	33	TAK1	TAK1	NNP
cord-265941-eff4le0g	481	34	kinase	kinase	NN
cord-265941-eff4le0g	481	35	inhibition	inhibition	NN
cord-265941-eff4le0g	481	36	TNF	tnf	NN
cord-265941-eff4le0g	481	37	-	-	HYPH
cord-265941-eff4le0g	481	38	alpha	alpha	NN
cord-265941-eff4le0g	481	39	induces	induce	VBZ
cord-265941-eff4le0g	481	40	two	two	CD
cord-265941-eff4le0g	481	41	distinct	distinct	JJ
cord-265941-eff4le0g	481	42	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	481	43	activation	activation	NN
cord-265941-eff4le0g	481	44	pathways	pathway	NNS
cord-265941-eff4le0g	482	1	Cleavage	cleavage	NN
cord-265941-eff4le0g	482	2	of	of	IN
cord-265941-eff4le0g	482	3	RIP3	RIP3	NNP
cord-265941-eff4le0g	482	4	inactivates	inactivate	VBZ
cord-265941-eff4le0g	482	5	its	-PRON-	PRP$
cord-265941-eff4le0g	482	6	caspase	caspase	NN
cord-265941-eff4le0g	482	7	-	-	HYPH
cord-265941-eff4le0g	482	8	independent	independent	JJ
cord-265941-eff4le0g	482	9	apoptosis	apoptosis	NN
cord-265941-eff4le0g	482	10	pathway	pathway	NN
cord-265941-eff4le0g	482	11	by	by	IN
cord-265941-eff4le0g	482	12	removal	removal	NN
cord-265941-eff4le0g	482	13	of	of	IN
cord-265941-eff4le0g	482	14	kinase	kinase	NN
cord-265941-eff4le0g	482	15	domain	domain	NN
cord-265941-eff4le0g	482	16	Cleavage	cleavage	NN
cord-265941-eff4le0g	482	17	of	of	IN
cord-265941-eff4le0g	482	18	the	the	DT
cord-265941-eff4le0g	482	19	death	death	NN
cord-265941-eff4le0g	482	20	domain	domain	NN
cord-265941-eff4le0g	482	21	kinase	kinase	NN
cord-265941-eff4le0g	482	22	RIP	RIP	NNP
cord-265941-eff4le0g	482	23	by	by	IN
cord-265941-eff4le0g	482	24	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	482	25	prompts	prompt	NNS
cord-265941-eff4le0g	483	1	TNF	TNF	NNP
cord-265941-eff4le0g	483	2	-	-	HYPH
cord-265941-eff4le0g	483	3	induced	induce	VBN
cord-265941-eff4le0g	483	4	apoptosis	apoptosis	NN
cord-265941-eff4le0g	483	5	Activation	activation	NN
cord-265941-eff4le0g	483	6	of	of	IN
cord-265941-eff4le0g	483	7	a	a	DT
cord-265941-eff4le0g	483	8	pro	pro	JJ
cord-265941-eff4le0g	483	9	-	-	JJ
cord-265941-eff4le0g	483	10	apoptotic	apoptotic	JJ
cord-265941-eff4le0g	483	11	amplification	amplification	NN
cord-265941-eff4le0g	483	12	loop	loop	NN
cord-265941-eff4le0g	483	13	through	through	IN
cord-265941-eff4le0g	483	14	inhibition	inhibition	NN
cord-265941-eff4le0g	483	15	of	of	IN
cord-265941-eff4le0g	483	16	NF	nf	NN
cord-265941-eff4le0g	483	17	-	-	HYPH
cord-265941-eff4le0g	483	18	κB	κB	NNP
cord-265941-eff4le0g	483	19	-	-	HYPH
cord-265941-eff4le0g	483	20	dependent	dependent	JJ
cord-265941-eff4le0g	483	21	survival	survival	NN
cord-265941-eff4le0g	483	22	signals	signal	NNS
cord-265941-eff4le0g	483	23	by	by	IN
cord-265941-eff4le0g	483	24	caspase	caspase	NN
cord-265941-eff4le0g	483	25	-	-	HYPH
cord-265941-eff4le0g	483	26	mediated	mediate	VBN
cord-265941-eff4le0g	483	27	inactivation	inactivation	NN
cord-265941-eff4le0g	483	28	of	of	IN
cord-265941-eff4le0g	483	29	RIP	rip	NN
cord-265941-eff4le0g	484	1	The	the	DT
cord-265941-eff4le0g	484	2	RIP1	RIP1	NNP
cord-265941-eff4le0g	484	3	/	/	SYM
cord-265941-eff4le0g	484	4	RIP3	RIP3	NNP
cord-265941-eff4le0g	484	5	necrosome	necrosome	NN
cord-265941-eff4le0g	484	6	forms	form	VBZ
cord-265941-eff4le0g	484	7	a	a	DT
cord-265941-eff4le0g	484	8	functional	functional	JJ
cord-265941-eff4le0g	484	9	amyloid	amyloid	NN
cord-265941-eff4le0g	484	10	signaling	signal	VBG
cord-265941-eff4le0g	484	11	complex	complex	NN
cord-265941-eff4le0g	484	12	required	require	VBN
cord-265941-eff4le0g	484	13	for	for	IN
cord-265941-eff4le0g	485	1	programmed	program	VBN
cord-265941-eff4le0g	485	2	necrosis	necrosis	NN
cord-265941-eff4le0g	485	3	Mixed	mix	VBN
cord-265941-eff4le0g	485	4	lineage	lineage	NN
cord-265941-eff4le0g	485	5	kinase	kinase	VBZ
cord-265941-eff4le0g	485	6	domain	domain	NN
cord-265941-eff4le0g	485	7	-	-	HYPH
cord-265941-eff4le0g	485	8	like	like	JJ
cord-265941-eff4le0g	485	9	protein	protein	NN
cord-265941-eff4le0g	485	10	mediates	mediate	VBZ
cord-265941-eff4le0g	485	11	necrosis	necrosis	NN
cord-265941-eff4le0g	485	12	signaling	signal	VBG
cord-265941-eff4le0g	485	13	downstream	downstream	RB
cord-265941-eff4le0g	485	14	of	of	IN
cord-265941-eff4le0g	486	1	RIP3	RIP3	NNP
cord-265941-eff4le0g	486	2	kinase	kinase	NN
cord-265941-eff4le0g	486	3	Mixed	mixed	JJ
cord-265941-eff4le0g	486	4	lineage	lineage	NN
cord-265941-eff4le0g	486	5	kinase	kinase	VBZ
cord-265941-eff4le0g	486	6	domain	domain	NN
cord-265941-eff4le0g	486	7	-	-	HYPH
cord-265941-eff4le0g	486	8	like	like	JJ
cord-265941-eff4le0g	486	9	protein	protein	NN
cord-265941-eff4le0g	486	10	MLKL	MLKL	NNP
cord-265941-eff4le0g	486	11	causes	cause	VBZ
cord-265941-eff4le0g	486	12	necrotic	necrotic	JJ
cord-265941-eff4le0g	486	13	membrane	membrane	NN
cord-265941-eff4le0g	486	14	disruption	disruption	NN
cord-265941-eff4le0g	486	15	upon	upon	IN
cord-265941-eff4le0g	486	16	phosphorylation	phosphorylation	NN
cord-265941-eff4le0g	486	17	by	by	IN
cord-265941-eff4le0g	486	18	RIP3	RIP3	NNP
cord-265941-eff4le0g	486	19	Apoptosis	Apoptosis	NNP
cord-265941-eff4le0g	486	20	Induced	induce	VBN
cord-265941-eff4le0g	486	21	by	by	IN
cord-265941-eff4le0g	486	22	the	the	DT
cord-265941-eff4le0g	486	23	Toll	Toll	NNP
cord-265941-eff4le0g	486	24	-	-	HYPH
cord-265941-eff4le0g	486	25	Like	like	JJ
cord-265941-eff4le0g	486	26	Receptor	receptor	NN
cord-265941-eff4le0g	486	27	Adaptor	adaptor	NN
cord-265941-eff4le0g	486	28	TRIF	TRIF	NNP
cord-265941-eff4le0g	486	29	Is	be	VBZ
cord-265941-eff4le0g	486	30	Dependent	dependent	JJ
cord-265941-eff4le0g	486	31	on	on	IN
cord-265941-eff4le0g	486	32	Its	-PRON-	PRP$
cord-265941-eff4le0g	486	33	Receptor	receptor	NN
cord-265941-eff4le0g	486	34	Interacting	interact	VBG
cord-265941-eff4le0g	486	35	Protein	Protein	NNP
cord-265941-eff4le0g	486	36	Homotypic	Homotypic	NNP
cord-265941-eff4le0g	486	37	Interaction	Interaction	NNP
cord-265941-eff4le0g	486	38	Motif	Motif	NNP
cord-265941-eff4le0g	486	39	Toll	toll	NN
cord-265941-eff4le0g	486	40	-	-	HYPH
cord-265941-eff4le0g	486	41	like	like	JJ
cord-265941-eff4le0g	486	42	receptor	receptor	NN
cord-265941-eff4le0g	486	43	3-mediated	3-mediated	CD
cord-265941-eff4le0g	486	44	necrosis	necrosis	NN
cord-265941-eff4le0g	486	45	via	via	IN
cord-265941-eff4le0g	486	46	TRIF	TRIF	NNP
cord-265941-eff4le0g	486	47	,	,	,
cord-265941-eff4le0g	486	48	RIP3	RIP3	NNP
cord-265941-eff4le0g	486	49	,	,	,
cord-265941-eff4le0g	486	50	and	and	CC
cord-265941-eff4le0g	486	51	MLKL	MLKL	NNP
cord-265941-eff4le0g	486	52	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	486	53	:	:	:
cord-265941-eff4le0g	487	1	innate	innate	JJ
cord-265941-eff4le0g	487	2	sensor	sensor	NN
cord-265941-eff4le0g	487	3	regulating	regulate	VBG
cord-265941-eff4le0g	487	4	cell	cell	NN
cord-265941-eff4le0g	487	5	death	death	NN
cord-265941-eff4le0g	487	6	and	and	CC
cord-265941-eff4le0g	487	7	inflammation	inflammation	NN
cord-265941-eff4le0g	487	8	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	487	9	and	and	CC
cord-265941-eff4le0g	487	10	TAK1	TAK1	NNP
cord-265941-eff4le0g	487	11	:	:	:
cord-265941-eff4le0g	487	12	master	master	NN
cord-265941-eff4le0g	487	13	regulators	regulator	NNS
cord-265941-eff4le0g	487	14	of	of	IN
cord-265941-eff4le0g	487	15	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	487	16	Inflammasome	Inflammasome	NNP
cord-265941-eff4le0g	487	17	/	/	SYM
cord-265941-eff4le0g	487	18	Pyroptosis	Pyroptosis	NNP
cord-265941-eff4le0g	487	19	,	,	,
cord-265941-eff4le0g	487	20	apoptosis	apoptosis	NN
cord-265941-eff4le0g	487	21	,	,	,
cord-265941-eff4le0g	487	22	and	and	CC
cord-265941-eff4le0g	487	23	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	487	24	(	(	-LRB-
cord-265941-eff4le0g	488	1	PANoptosis	PANoptosis	NNP
cord-265941-eff4le0g	488	2	)	)	-RRB-
cord-265941-eff4le0g	489	1	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	489	2	counteracts	counteract	VBZ
cord-265941-eff4le0g	489	3	ZBP1-mediated	zbp1-mediate	VBN
cord-265941-eff4le0g	489	4	necroptosis	necroptosis	NN
cord-265941-eff4le0g	489	5	to	to	TO
cord-265941-eff4le0g	489	6	inhibit	inhibit	VB
cord-265941-eff4le0g	489	7	inflammation	inflammation	NN
cord-265941-eff4le0g	489	8	RIPK1	ripk1	JJ
cord-265941-eff4le0g	489	9	inhibits	inhibit	VBZ
cord-265941-eff4le0g	489	10	ZBP1-driven	ZBP1-driven	NNP
cord-265941-eff4le0g	489	11	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	489	12	during	during	IN
cord-265941-eff4le0g	489	13	development	development	NN
cord-265941-eff4le0g	489	14	Innate	innate	VBP
cord-265941-eff4le0g	489	15	immune	immune	JJ
cord-265941-eff4le0g	489	16	priming	priming	NN
cord-265941-eff4le0g	489	17	in	in	IN
cord-265941-eff4le0g	489	18	the	the	DT
cord-265941-eff4le0g	489	19	absence	absence	NN
cord-265941-eff4le0g	489	20	of	of	IN
cord-265941-eff4le0g	489	21	TAK1	TAK1	NNP
cord-265941-eff4le0g	490	1	drives	drive	VBZ
cord-265941-eff4le0g	490	2	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	490	3	kinase	kinase	NNP
cord-265941-eff4le0g	490	4	activityindependent	activityindependent	JJ
cord-265941-eff4le0g	490	5	pyroptosis	pyroptosis	NN
cord-265941-eff4le0g	490	6	,	,	,
cord-265941-eff4le0g	490	7	apoptosis	apoptosis	NN
cord-265941-eff4le0g	490	8	,	,	,
cord-265941-eff4le0g	490	9	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	490	10	,	,	,
cord-265941-eff4le0g	490	11	and	and	CC
cord-265941-eff4le0g	490	12	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	490	13	disease	disease	NN
cord-265941-eff4le0g	491	1	The	the	DT
cord-265941-eff4le0g	491	2	PANoptosome	PANoptosome	NNP
cord-265941-eff4le0g	491	3	:	:	:
cord-265941-eff4le0g	491	4	a	a	DT
cord-265941-eff4le0g	491	5	deadly	deadly	JJ
cord-265941-eff4le0g	491	6	protein	protein	NN
cord-265941-eff4le0g	491	7	complex	complex	NN
cord-265941-eff4le0g	491	8	driving	drive	VBG
cord-265941-eff4le0g	491	9	pyroptosis	pyroptosis	NN
cord-265941-eff4le0g	491	10	,	,	,
cord-265941-eff4le0g	491	11	apoptosis	apoptosis	NN
cord-265941-eff4le0g	491	12	,	,	,
cord-265941-eff4le0g	491	13	and	and	CC
cord-265941-eff4le0g	491	14	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	491	15	(	(	-LRB-
cord-265941-eff4le0g	491	16	PANoptosis	PANoptosis	NNP
cord-265941-eff4le0g	491	17	)	)	-RRB-
cord-265941-eff4le0g	491	18	,	,	,
cord-265941-eff4le0g	491	19	Front	Front	NNP
cord-265941-eff4le0g	491	20	Targeting	target	VBG
cord-265941-eff4le0g	491	21	apoptosis	apoptosis	NN
cord-265941-eff4le0g	491	22	pathways	pathway	NNS
cord-265941-eff4le0g	491	23	in	in	IN
cord-265941-eff4le0g	491	24	infections	infection	NNS
cord-265941-eff4le0g	492	1	The	the	DT
cord-265941-eff4le0g	492	2	suppression	suppression	NN
cord-265941-eff4le0g	492	3	of	of	IN
cord-265941-eff4le0g	492	4	apoptosis	apoptosis	NN
cord-265941-eff4le0g	492	5	by	by	IN
cord-265941-eff4le0g	492	6	α	α	NN
cord-265941-eff4le0g	492	7	-	-	HYPH
cord-265941-eff4le0g	492	8	herpesvirus	herpesvirus	NN
cord-265941-eff4le0g	492	9	The	the	DT
cord-265941-eff4le0g	492	10	ribonucleotide	ribonucleotide	NN
cord-265941-eff4le0g	492	11	reductase	reductase	NN
cord-265941-eff4le0g	492	12	R1	r1	NN
cord-265941-eff4le0g	492	13	subunits	subunit	NNS
cord-265941-eff4le0g	492	14	of	of	IN
cord-265941-eff4le0g	492	15	herpes	herpes	NN
cord-265941-eff4le0g	492	16	simplex	simplex	NNP
cord-265941-eff4le0g	492	17	virus	virus	NN
cord-265941-eff4le0g	492	18	types	type	NNS
cord-265941-eff4le0g	492	19	1	1	CD
cord-265941-eff4le0g	492	20	and	and	CC
cord-265941-eff4le0g	492	21	2	2	CD
cord-265941-eff4le0g	492	22	protect	protect	VBP
cord-265941-eff4le0g	492	23	cells	cell	NNS
cord-265941-eff4le0g	492	24	against	against	IN
cord-265941-eff4le0g	492	25	TNFα	TNFα	NNS
cord-265941-eff4le0g	492	26	-	-	:
cord-265941-eff4le0g	492	27	and	and	CC
cord-265941-eff4le0g	492	28	FasL	FasL	NNP
cord-265941-eff4le0g	492	29	-	-	HYPH
cord-265941-eff4le0g	492	30	induced	induce	VBN
cord-265941-eff4le0g	492	31	apoptosis	apoptosis	NN
cord-265941-eff4le0g	492	32	by	by	IN
cord-265941-eff4le0g	492	33	interacting	interact	VBG
cord-265941-eff4le0g	492	34	with	with	IN
cord-265941-eff4le0g	492	35	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	493	1	The	the	DT
cord-265941-eff4le0g	493	2	ribonucleotide	ribonucleotide	NN
cord-265941-eff4le0g	493	3	reductase	reductase	NN
cord-265941-eff4le0g	493	4	R1	r1	NN
cord-265941-eff4le0g	493	5	subunits	subunit	NNS
cord-265941-eff4le0g	493	6	of	of	IN
cord-265941-eff4le0g	493	7	herpes	herpes	NN
cord-265941-eff4le0g	493	8	simplex	simplex	NNP
cord-265941-eff4le0g	493	9	virus	virus	NN
cord-265941-eff4le0g	493	10	1	1	CD
cord-265941-eff4le0g	493	11	and	and	CC
cord-265941-eff4le0g	493	12	2	2	CD
cord-265941-eff4le0g	493	13	protect	protect	VBP
cord-265941-eff4le0g	493	14	cells	cell	NNS
cord-265941-eff4le0g	493	15	against	against	IN
cord-265941-eff4le0g	493	16	poly(I	poly(I	NNP
cord-265941-eff4le0g	493	17	⋅	⋅	NNP
cord-265941-eff4le0g	493	18	C)-induced	C)-induced	NNP
cord-265941-eff4le0g	493	19	apoptosis	apoptosis	NN
cord-265941-eff4le0g	493	20	The	the	DT
cord-265941-eff4le0g	493	21	Zα2	zα2	CD
cord-265941-eff4le0g	493	22	domain	domain	NN
cord-265941-eff4le0g	493	23	of	of	IN
cord-265941-eff4le0g	493	24	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	493	25	is	be	VBZ
cord-265941-eff4le0g	493	26	a	a	DT
cord-265941-eff4le0g	493	27	molecular	molecular	JJ
cord-265941-eff4le0g	493	28	switch	switch	NN
cord-265941-eff4le0g	493	29	regulating	regulate	VBG
cord-265941-eff4le0g	493	30	influenza	influenza	NN
cord-265941-eff4le0g	493	31	-	-	HYPH
cord-265941-eff4le0g	493	32	induced	induce	VBN
cord-265941-eff4le0g	493	33	PANoptosis	panoptosis	NN
cord-265941-eff4le0g	493	34	and	and	CC
cord-265941-eff4le0g	493	35	perinatal	perinatal	JJ
cord-265941-eff4le0g	493	36	lethality	lethality	NN
cord-265941-eff4le0g	493	37	during	during	IN
cord-265941-eff4le0g	493	38	development	development	NN
cord-265941-eff4le0g	493	39	DAI	DAI	NNP
cord-265941-eff4le0g	493	40	senses	sense	VBZ
cord-265941-eff4le0g	493	41	influenza	influenza	NN
cord-265941-eff4le0g	493	42	a	a	DT
cord-265941-eff4le0g	493	43	virus	virus	NN
cord-265941-eff4le0g	493	44	genomic	genomic	JJ
cord-265941-eff4le0g	493	45	RNA	RNA	NNP
cord-265941-eff4le0g	493	46	and	and	CC
cord-265941-eff4le0g	493	47	activates	activate	VBZ
cord-265941-eff4le0g	493	48	RIPK3-Dependent	ripk3-dependent	NN
cord-265941-eff4le0g	493	49	cell	cell	NN
cord-265941-eff4le0g	493	50	death	death	NN
cord-265941-eff4le0g	494	1	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	494	2	/	/	SYM
cord-265941-eff4le0g	494	3	DAI	DAI	NNP
cord-265941-eff4le0g	494	4	is	be	VBZ
cord-265941-eff4le0g	494	5	an	an	DT
cord-265941-eff4le0g	494	6	innate	innate	JJ
cord-265941-eff4le0g	494	7	sensor	sensor	NN
cord-265941-eff4le0g	494	8	of	of	IN
cord-265941-eff4le0g	494	9	influenza	influenza	NN
cord-265941-eff4le0g	494	10	virus	virus	NN
cord-265941-eff4le0g	494	11	triggering	trigger	VBG
cord-265941-eff4le0g	494	12	the	the	DT
cord-265941-eff4le0g	494	13	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	494	14	inflammasome	inflammasome	NN
cord-265941-eff4le0g	494	15	and	and	CC
cord-265941-eff4le0g	494	16	programmed	program	VBD
cord-265941-eff4le0g	494	17	cell	cell	NN
cord-265941-eff4le0g	494	18	death	death	NN
cord-265941-eff4le0g	494	19	pathways	pathway	NNS
cord-265941-eff4le0g	495	1	ZBP1/	ZBP1/	NNP
cord-265941-eff4le0g	496	1	DAI	DAI	NNP
cord-265941-eff4le0g	496	2	ubiquitination	ubiquitination	NN
cord-265941-eff4le0g	496	3	and	and	CC
cord-265941-eff4le0g	496	4	sensing	sensing	NN
cord-265941-eff4le0g	496	5	of	of	IN
cord-265941-eff4le0g	496	6	influenza	influenza	NN
cord-265941-eff4le0g	497	1	vRNPs	vRNPs	NNP
cord-265941-eff4le0g	497	2	activate	activate	VB
cord-265941-eff4le0g	497	3	programmed	program	VBN
cord-265941-eff4le0g	497	4	cell	cell	NN
cord-265941-eff4le0g	497	5	death	death	NN
cord-265941-eff4le0g	498	1	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	498	2	activates	activate	VBZ
cord-265941-eff4le0g	498	3	parallel	parallel	JJ
cord-265941-eff4le0g	498	4	pathways	pathway	NNS
cord-265941-eff4le0g	498	5	of	of	IN
cord-265941-eff4le0g	498	6	MLKL	MLKL	NNP
cord-265941-eff4le0g	498	7	-	-	HYPH
cord-265941-eff4le0g	498	8	Driven	drive	VBN
cord-265941-eff4le0g	498	9	necroptosis	necroptosis	NN
cord-265941-eff4le0g	498	10	and	and	CC
cord-265941-eff4le0g	498	11	FADD	FADD	NNP
cord-265941-eff4le0g	498	12	-	-	HYPH
cord-265941-eff4le0g	498	13	Mediated	mediate	VBN
cord-265941-eff4le0g	498	14	apoptosis	apoptosis	NN
cord-265941-eff4le0g	498	15	to	to	TO
cord-265941-eff4le0g	498	16	protect	protect	VB
cord-265941-eff4le0g	498	17	against	against	IN
cord-265941-eff4le0g	498	18	influenza	influenza	NN
cord-265941-eff4le0g	498	19	a	a	DT
cord-265941-eff4le0g	498	20	virus	virus	NN
cord-265941-eff4le0g	499	1	Cell	cell	NN
cord-265941-eff4le0g	499	2	-	-	HYPH
cord-265941-eff4le0g	499	3	extrinsic	extrinsic	JJ
cord-265941-eff4le0g	499	4	TNF	TNF	NNP
cord-265941-eff4le0g	499	5	collaborates	collaborate	VBZ
cord-265941-eff4le0g	499	6	with	with	IN
cord-265941-eff4le0g	499	7	TRIF	TRIF	NNP
cord-265941-eff4le0g	499	8	signaling	signal	VBG
cord-265941-eff4le0g	499	9	to	to	TO
cord-265941-eff4le0g	499	10	promote	promote	VB
cord-265941-eff4le0g	500	1	yersinia	yersinia	NN
cord-265941-eff4le0g	500	2	-	-	HYPH
cord-265941-eff4le0g	500	3	induced	induce	VBN
cord-265941-eff4le0g	500	4	apoptosis	apoptosis	NN
cord-265941-eff4le0g	500	5	RIPK1-dependent	RIPK1-dependent	.
cord-265941-eff4le0g	501	1	apoptosis	apoptosis	NN
cord-265941-eff4le0g	501	2	bypasses	bypass	VBZ
cord-265941-eff4le0g	501	3	pathogen	pathogen	NN
cord-265941-eff4le0g	501	4	blockade	blockade	NN
cord-265941-eff4le0g	501	5	of	of	IN
cord-265941-eff4le0g	501	6	innate	innate	JJ
cord-265941-eff4le0g	501	7	signaling	signaling	NN
cord-265941-eff4le0g	501	8	to	to	TO
cord-265941-eff4le0g	501	9	promote	promote	VB
cord-265941-eff4le0g	501	10	immune	immune	JJ
cord-265941-eff4le0g	501	11	defense	defense	NN
cord-265941-eff4le0g	501	12	Induction	induction	NN
cord-265941-eff4le0g	501	13	of	of	IN
cord-265941-eff4le0g	501	14	necrotic	necrotic	JJ
cord-265941-eff4le0g	501	15	-	-	HYPH
cord-265941-eff4le0g	501	16	like	like	JJ
cord-265941-eff4le0g	501	17	cell	cell	NN
cord-265941-eff4le0g	501	18	death	death	NN
cord-265941-eff4le0g	501	19	by	by	IN
cord-265941-eff4le0g	501	20	tumor	tumor	NN
cord-265941-eff4le0g	501	21	necrosis	necrosis	NN
cord-265941-eff4le0g	501	22	factor	factor	NN
cord-265941-eff4le0g	501	23	alpha	alpha	NN
cord-265941-eff4le0g	501	24	and	and	CC
cord-265941-eff4le0g	501	25	caspase	caspase	NN
cord-265941-eff4le0g	501	26	inhibitors	inhibitor	NNS
cord-265941-eff4le0g	501	27	:	:	:
cord-265941-eff4le0g	502	1	novel	novel	JJ
cord-265941-eff4le0g	502	2	mechanism	mechanism	NN
cord-265941-eff4le0g	502	3	for	for	IN
cord-265941-eff4le0g	502	4	killing	kill	VBG
cord-265941-eff4le0g	502	5	virus	virus	NN
cord-265941-eff4le0g	502	6	-	-	HYPH
cord-265941-eff4le0g	502	7	infected	infect	VBN
cord-265941-eff4le0g	502	8	cells	cell	NNS
cord-265941-eff4le0g	503	1	Phosphorylation	Phosphorylation	NNP
cord-265941-eff4le0g	503	2	-	-	HYPH
cord-265941-eff4le0g	503	3	driven	drive	VBN
cord-265941-eff4le0g	503	4	assembly	assembly	NN
cord-265941-eff4le0g	503	5	of	of	IN
cord-265941-eff4le0g	503	6	the	the	DT
cord-265941-eff4le0g	503	7	RIP1-RIP3	RIP1-RIP3	NNP
cord-265941-eff4le0g	503	8	complex	complex	NN
cord-265941-eff4le0g	503	9	regulates	regulate	VBZ
cord-265941-eff4le0g	503	10	programmed	program	VBN
cord-265941-eff4le0g	503	11	necrosis	necrosis	NN
cord-265941-eff4le0g	503	12	and	and	CC
cord-265941-eff4le0g	503	13	virus	virus	NN
cord-265941-eff4le0g	503	14	-	-	HYPH
cord-265941-eff4le0g	503	15	induced	induce	VBN
cord-265941-eff4le0g	503	16	inflammation	inflammation	NN
cord-265941-eff4le0g	503	17	A	a	DT
cord-265941-eff4le0g	503	18	role	role	NN
cord-265941-eff4le0g	503	19	for	for	IN
cord-265941-eff4le0g	503	20	tumor	tumor	NN
cord-265941-eff4le0g	503	21	necrosis	necrosis	NN
cord-265941-eff4le0g	503	22	factor	factor	NN
cord-265941-eff4le0g	503	23	receptor-2	receptor-2	NNP
cord-265941-eff4le0g	503	24	and	and	CC
cord-265941-eff4le0g	503	25	receptorinteracting	receptorinteracte	VBG
cord-265941-eff4le0g	503	26	protein	protein	NN
cord-265941-eff4le0g	503	27	in	in	IN
cord-265941-eff4le0g	503	28	programmed	programmed	JJ
cord-265941-eff4le0g	503	29	necrosis	necrosis	NN
cord-265941-eff4le0g	503	30	and	and	CC
cord-265941-eff4le0g	503	31	antiviral	antiviral	JJ
cord-265941-eff4le0g	503	32	responses	response	NNS
cord-265941-eff4le0g	504	1	Cutting	cut	VBG
cord-265941-eff4le0g	504	2	edge	edge	NN
cord-265941-eff4le0g	504	3	:	:	:
cord-265941-eff4le0g	505	1	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	506	1	Kinase	kinase	NN
cord-265941-eff4le0g	506	2	inactive	inactive	JJ
cord-265941-eff4le0g	506	3	mice	mouse	NNS
cord-265941-eff4le0g	506	4	are	be	VBP
cord-265941-eff4le0g	506	5	viable	viable	JJ
cord-265941-eff4le0g	506	6	and	and	CC
cord-265941-eff4le0g	506	7	protected	protect	VBN
cord-265941-eff4le0g	506	8	from	from	IN
cord-265941-eff4le0g	506	9	TNF	TNF	NNP
cord-265941-eff4le0g	506	10	-	-	HYPH
cord-265941-eff4le0g	506	11	induced	induce	VBN
cord-265941-eff4le0g	506	12	necroptosis	necroptosis	NN
cord-265941-eff4le0g	506	13	in	in	IN
cord-265941-eff4le0g	506	14	vivo	vivo	NNP
cord-265941-eff4le0g	506	15	RIP1	RIP1	NNP
cord-265941-eff4le0g	506	16	kinase	kinase	NN
cord-265941-eff4le0g	506	17	activity	activity	NN
cord-265941-eff4le0g	506	18	is	be	VBZ
cord-265941-eff4le0g	506	19	critical	critical	JJ
cord-265941-eff4le0g	506	20	for	for	IN
cord-265941-eff4le0g	506	21	skin	skin	NN
cord-265941-eff4le0g	506	22	inflammation	inflammation	NN
cord-265941-eff4le0g	506	23	but	but	CC
cord-265941-eff4le0g	506	24	not	not	RB
cord-265941-eff4le0g	506	25	for	for	IN
cord-265941-eff4le0g	506	26	viral	viral	JJ
cord-265941-eff4le0g	506	27	propagation	propagation	NN
cord-265941-eff4le0g	506	28	Identification	identification	NN
cord-265941-eff4le0g	506	29	of	of	IN
cord-265941-eff4le0g	506	30	a	a	DT
cord-265941-eff4le0g	506	31	conserved	conserved	JJ
cord-265941-eff4le0g	506	32	motif	motif	NN
cord-265941-eff4le0g	506	33	that	that	WDT
cord-265941-eff4le0g	506	34	is	be	VBZ
cord-265941-eff4le0g	506	35	necessary	necessary	JJ
cord-265941-eff4le0g	506	36	for	for	IN
cord-265941-eff4le0g	506	37	binding	bind	VBG
cord-265941-eff4le0g	506	38	of	of	IN
cord-265941-eff4le0g	506	39	the	the	DT
cord-265941-eff4le0g	506	40	vaccinia	vaccinia	NN
cord-265941-eff4le0g	506	41	virus	virus	NN
cord-265941-eff4le0g	506	42	E3L	e3l	NN
cord-265941-eff4le0g	506	43	gene	gene	NN
cord-265941-eff4le0g	506	44	products	product	NNS
cord-265941-eff4le0g	506	45	to	to	IN
cord-265941-eff4le0g	506	46	double	double	RB
cord-265941-eff4le0g	506	47	-	-	HYPH
cord-265941-eff4le0g	506	48	stranded	strand	VBN
cord-265941-eff4le0g	506	49	RNA	RNA	NNP
cord-265941-eff4le0g	506	50	Inhibition	Inhibition	NNP
cord-265941-eff4le0g	506	51	of	of	IN
cord-265941-eff4le0g	506	52	DAI	DAI	NNP
cord-265941-eff4le0g	506	53	-	-	HYPH
cord-265941-eff4le0g	506	54	dependent	dependent	JJ
cord-265941-eff4le0g	506	55	necroptosis	necroptosis	NN
cord-265941-eff4le0g	506	56	by	by	IN
cord-265941-eff4le0g	506	57	the	the	DT
cord-265941-eff4le0g	506	58	Z	Z	NNP
cord-265941-eff4le0g	506	59	-	-	HYPH
cord-265941-eff4le0g	506	60	DNA	dna	NN
cord-265941-eff4le0g	506	61	binding	binding	NN
cord-265941-eff4le0g	506	62	domain	domain	NN
cord-265941-eff4le0g	506	63	of	of	IN
cord-265941-eff4le0g	506	64	the	the	DT
cord-265941-eff4le0g	506	65	vaccinia	vaccinia	NN
cord-265941-eff4le0g	506	66	virus	virus	NN
cord-265941-eff4le0g	506	67	innate	innate	VBP
cord-265941-eff4le0g	506	68	immune	immune	JJ
cord-265941-eff4le0g	506	69	evasion	evasion	NN
cord-265941-eff4le0g	506	70	protein	protein	NN
cord-265941-eff4le0g	506	71	Differential	differential	JJ
cord-265941-eff4le0g	506	72	function	function	NN
cord-265941-eff4le0g	506	73	and	and	CC
cord-265941-eff4le0g	506	74	expression	expression	NN
cord-265941-eff4le0g	506	75	of	of	IN
cord-265941-eff4le0g	506	76	the	the	DT
cord-265941-eff4le0g	506	77	viral	viral	JJ
cord-265941-eff4le0g	506	78	inhibitor	inhibitor	NN
cord-265941-eff4le0g	506	79	of	of	IN
cord-265941-eff4le0g	506	80	caspase	caspase	NN
cord-265941-eff4le0g	506	81	8-induced	8-induced	CD
cord-265941-eff4le0g	506	82	apoptosis	apoptosis	NN
cord-265941-eff4le0g	506	83	(	(	-LRB-
cord-265941-eff4le0g	506	84	vICA	vICA	NNP
cord-265941-eff4le0g	506	85	)	)	-RRB-
cord-265941-eff4le0g	506	86	and	and	CC
cord-265941-eff4le0g	506	87	the	the	DT
cord-265941-eff4le0g	506	88	viral	viral	JJ
cord-265941-eff4le0g	506	89	mitochondria	mitochondria	NN
cord-265941-eff4le0g	506	90	-	-	HYPH
cord-265941-eff4le0g	506	91	localized	localize	VBN
cord-265941-eff4le0g	506	92	inhibitor	inhibitor	NN
cord-265941-eff4le0g	506	93	of	of	IN
cord-265941-eff4le0g	506	94	apoptosis	apoptosis	NN
cord-265941-eff4le0g	506	95	(	(	-LRB-
cord-265941-eff4le0g	506	96	vMIA	vmia	JJ
cord-265941-eff4le0g	506	97	)	)	-RRB-
cord-265941-eff4le0g	506	98	cell	cell	NN
cord-265941-eff4le0g	506	99	death	death	NN
cord-265941-eff4le0g	506	100	suppressors	suppressor	NNS
cord-265941-eff4le0g	506	101	conserved	conserve	VBN
cord-265941-eff4le0g	506	102	in	in	IN
cord-265941-eff4le0g	506	103	primate	primate	NN
cord-265941-eff4le0g	506	104	and	and	CC
cord-265941-eff4le0g	506	105	rodent	rodent	NN
cord-265941-eff4le0g	506	106	cytomegaloviruses	cytomegalovirus	NNS
cord-265941-eff4le0g	506	107	A	a	DT
cord-265941-eff4le0g	506	108	cytomegalovirus	cytomegalovirus	NN
cord-265941-eff4le0g	506	109	-	-	HYPH
cord-265941-eff4le0g	506	110	encoded	encode	VBN
cord-265941-eff4le0g	506	111	inhibitor	inhibitor	NN
cord-265941-eff4le0g	506	112	of	of	IN
cord-265941-eff4le0g	506	113	apoptosis	apoptosis	NN
cord-265941-eff4le0g	506	114	that	that	WDT
cord-265941-eff4le0g	506	115	suppresses	suppress	VBZ
cord-265941-eff4le0g	506	116	caspase-8	caspase-8	NNP
cord-265941-eff4le0g	506	117	activation	activation	NN
cord-265941-eff4le0g	506	118	Cytomegalovirus	Cytomegalovirus	NNP
cord-265941-eff4le0g	506	119	M45	M45	NNP
cord-265941-eff4le0g	506	120	cell	cell	NN
cord-265941-eff4le0g	506	121	death	death	NN
cord-265941-eff4le0g	506	122	suppression	suppression	NN
cord-265941-eff4le0g	506	123	requires	require	VBZ
cord-265941-eff4le0g	506	124	receptor	receptor	NN
cord-265941-eff4le0g	506	125	-	-	HYPH
cord-265941-eff4le0g	506	126	interacting	interact	VBG
cord-265941-eff4le0g	506	127	protein	protein	NN
cord-265941-eff4le0g	506	128	(	(	-LRB-
cord-265941-eff4le0g	506	129	RIP	RIP	NNP
cord-265941-eff4le0g	506	130	)	)	-RRB-
cord-265941-eff4le0g	506	131	homotypic	homotypic	JJ
cord-265941-eff4le0g	506	132	interaction	interaction	NN
cord-265941-eff4le0g	506	133	motif	motif	NN
cord-265941-eff4le0g	506	134	(	(	-LRB-
cord-265941-eff4le0g	506	135	RHIM)-dependent	rhim)-dependent	CD
cord-265941-eff4le0g	506	136	interaction	interaction	NN
cord-265941-eff4le0g	506	137	with	with	IN
cord-265941-eff4le0g	506	138	RIP1	RIP1	NNP
cord-265941-eff4le0g	506	139	DAI	DAI	NNP
cord-265941-eff4le0g	506	140	/	/	SYM
cord-265941-eff4le0g	506	141	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	506	142	/	/	SYM
cord-265941-eff4le0g	506	143	DLM-1	DLM-1	NNP
cord-265941-eff4le0g	506	144	complexes	complex	NNS
cord-265941-eff4le0g	506	145	with	with	IN
cord-265941-eff4le0g	506	146	RIP3	RIP3	NNS
cord-265941-eff4le0g	506	147	to	to	TO
cord-265941-eff4le0g	506	148	mediate	mediate	VB
cord-265941-eff4le0g	506	149	virus	virus	NN
cord-265941-eff4le0g	506	150	-	-	HYPH
cord-265941-eff4le0g	506	151	induced	induce	VBN
cord-265941-eff4le0g	506	152	programmed	program	VBN
cord-265941-eff4le0g	506	153	necrosis	necrosis	NN
cord-265941-eff4le0g	506	154	that	that	WDT
cord-265941-eff4le0g	506	155	is	be	VBZ
cord-265941-eff4le0g	506	156	targeted	target	VBN
cord-265941-eff4le0g	506	157	by	by	IN
cord-265941-eff4le0g	506	158	murine	murine	JJ
cord-265941-eff4le0g	506	159	cytomegalovirus	cytomegalovirus	NN
cord-265941-eff4le0g	506	160	vIRA	vira	XX
cord-265941-eff4le0g	507	1	The	the	DT
cord-265941-eff4le0g	507	2	ribonucleotide	ribonucleotide	NN
cord-265941-eff4le0g	507	3	reductase	reductase	NN
cord-265941-eff4le0g	507	4	R1	R1	NNP
cord-265941-eff4le0g	507	5	homolog	homolog	NN
cord-265941-eff4le0g	507	6	of	of	IN
cord-265941-eff4le0g	507	7	murine	murine	JJ
cord-265941-eff4le0g	507	8	cytomegalovirus	cytomegalovirus	NN
cord-265941-eff4le0g	507	9	is	be	VBZ
cord-265941-eff4le0g	507	10	not	not	RB
cord-265941-eff4le0g	507	11	a	a	DT
cord-265941-eff4le0g	507	12	functional	functional	JJ
cord-265941-eff4le0g	507	13	enzyme	enzyme	NN
cord-265941-eff4le0g	507	14	subunit	subunit	NN
cord-265941-eff4le0g	507	15	but	but	CC
cord-265941-eff4le0g	507	16	is	be	VBZ
cord-265941-eff4le0g	507	17	required	require	VBN
cord-265941-eff4le0g	507	18	for	for	IN
cord-265941-eff4le0g	507	19	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	507	20	Virus	Virus	NNP
cord-265941-eff4le0g	507	21	inhibition	inhibition	NN
cord-265941-eff4le0g	507	22	of	of	IN
cord-265941-eff4le0g	507	23	RIP3-dependent	rip3-dependent	JJ
cord-265941-eff4le0g	507	24	necrosis	necrosis	NN
cord-265941-eff4le0g	507	25	Murine	Murine	NNP
cord-265941-eff4le0g	507	26	cytomegalovirus	cytomegalovirus	NN
cord-265941-eff4le0g	507	27	IE3-dependent	ie3-dependent	NN
cord-265941-eff4le0g	507	28	transcription	transcription	NN
cord-265941-eff4le0g	507	29	is	be	VBZ
cord-265941-eff4le0g	507	30	required	require	VBN
cord-265941-eff4le0g	507	31	for	for	IN
cord-265941-eff4le0g	507	32	DAI	DAI	NNP
cord-265941-eff4le0g	507	33	/	/	SYM
cord-265941-eff4le0g	507	34	ZBP1-mediated	zbp1-mediate	VBN
cord-265941-eff4le0g	507	35	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	507	36	Human	Human	NNP
cord-265941-eff4le0g	507	37	cytomegalovirus	cytomegalovirus	NNP
cord-265941-eff4le0g	507	38	induces	induce	VBZ
cord-265941-eff4le0g	507	39	the	the	DT
cord-265941-eff4le0g	507	40	interferon	interferon	NN
cord-265941-eff4le0g	507	41	response	response	NN
cord-265941-eff4le0g	507	42	via	via	IN
cord-265941-eff4le0g	507	43	the	the	DT
cord-265941-eff4le0g	507	44	DNA	dna	NN
cord-265941-eff4le0g	507	45	sensor	sensor	NN
cord-265941-eff4le0g	508	1	ZBP1	ZBP1	NNP
cord-265941-eff4le0g	508	2	Suppression	Suppression	NNP
cord-265941-eff4le0g	508	3	of	of	IN
cord-265941-eff4le0g	508	4	RIP3-dependent	RIP3-dependent	NNP
cord-265941-eff4le0g	508	5	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	508	6	by	by	IN
cord-265941-eff4le0g	508	7	human	human	JJ
cord-265941-eff4le0g	508	8	cytomegalovirus	cytomegalovirus	NNP
cord-265941-eff4le0g	508	9	Herpes	Herpes	NNP
cord-265941-eff4le0g	508	10	simplex	simplex	NN
cord-265941-eff4le0g	508	11	virus	virus	NN
cord-265941-eff4le0g	508	12	suppresses	suppress	VBZ
cord-265941-eff4le0g	508	13	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	508	14	in	in	IN
cord-265941-eff4le0g	508	15	human	human	JJ
cord-265941-eff4le0g	508	16	cells	cell	NNS
cord-265941-eff4le0g	508	17	RIP1	RIP1	NNP
cord-265941-eff4le0g	508	18	/	/	SYM
cord-265941-eff4le0g	508	19	RIP3	RIP3	NNS
cord-265941-eff4le0g	508	20	binding	bind	VBG
cord-265941-eff4le0g	508	21	to	to	IN
cord-265941-eff4le0g	508	22	HSV-1	HSV-1	NNP
cord-265941-eff4le0g	508	23	ICP6	ICP6	NNP
cord-265941-eff4le0g	509	1	initiates	initiate	VBZ
cord-265941-eff4le0g	509	2	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	509	3	to	to	TO
cord-265941-eff4le0g	509	4	restrict	restrict	VB
cord-265941-eff4le0g	509	5	virus	virus	NN
cord-265941-eff4le0g	509	6	propagation	propagation	NN
cord-265941-eff4le0g	509	7	in	in	IN
cord-265941-eff4le0g	509	8	mice	mouse	NNS
cord-265941-eff4le0g	509	9	Direct	direct	JJ
cord-265941-eff4le0g	509	10	activation	activation	NN
cord-265941-eff4le0g	509	11	of	of	IN
cord-265941-eff4le0g	509	12	RIP3	RIP3	NNP
cord-265941-eff4le0g	509	13	/	/	SYM
cord-265941-eff4le0g	509	14	MLKL	mlkl	NN
cord-265941-eff4le0g	509	15	-	-	HYPH
cord-265941-eff4le0g	509	16	dependent	dependent	JJ
cord-265941-eff4le0g	509	17	necrosis	necrosis	NN
cord-265941-eff4le0g	509	18	by	by	IN
cord-265941-eff4le0g	509	19	herpes	herpes	NNP
cord-265941-eff4le0g	509	20	simplex	simplex	NNP
cord-265941-eff4le0g	509	21	virus	virus	NN
cord-265941-eff4le0g	509	22	1	1	CD
cord-265941-eff4le0g	509	23	(	(	-LRB-
cord-265941-eff4le0g	509	24	HSV-1	hsv-1	NN
cord-265941-eff4le0g	509	25	)	)	-RRB-
cord-265941-eff4le0g	510	1	protein	protein	NN
cord-265941-eff4le0g	510	2	ICP6	ICP6	NNP
cord-265941-eff4le0g	510	3	triggers	trigger	VBZ
cord-265941-eff4le0g	510	4	host	host	NN
cord-265941-eff4le0g	510	5	antiviral	antiviral	JJ
cord-265941-eff4le0g	510	6	defense	defense	NN
cord-265941-eff4le0g	511	1	The	the	DT
cord-265941-eff4le0g	511	2	ubiquitin	ubiquitin	NN
cord-265941-eff4le0g	511	3	-	-	HYPH
cord-265941-eff4le0g	511	4	modifying	modify	VBG
cord-265941-eff4le0g	511	5	enzyme	enzyme	NN
cord-265941-eff4le0g	511	6	A20	A20	NNP
cord-265941-eff4le0g	511	7	restricts	restrict	VBZ
cord-265941-eff4le0g	511	8	ubiquitination	ubiquitination	NN
cord-265941-eff4le0g	511	9	of	of	IN
cord-265941-eff4le0g	511	10	the	the	DT
cord-265941-eff4le0g	511	11	kinase	kinase	NN
cord-265941-eff4le0g	511	12	RIPK3	ripk3	NN
cord-265941-eff4le0g	511	13	and	and	CC
cord-265941-eff4le0g	511	14	protects	protect	VBZ
cord-265941-eff4le0g	511	15	cells	cell	NNS
cord-265941-eff4le0g	511	16	from	from	IN
cord-265941-eff4le0g	511	17	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	512	1	Viral	viral	JJ
cord-265941-eff4le0g	512	2	MLKL	MLKL	NNP
cord-265941-eff4le0g	512	3	homologs	homolog	NNS
cord-265941-eff4le0g	512	4	subvert	subvert	VBP
cord-265941-eff4le0g	512	5	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	512	6	cell	cell	NN
cord-265941-eff4le0g	512	7	death	death	NN
cord-265941-eff4le0g	512	8	by	by	IN
cord-265941-eff4le0g	512	9	sequestering	sequester	VBG
cord-265941-eff4le0g	512	10	cellular	cellular	JJ
cord-265941-eff4le0g	512	11	RIPK3	ripk3	NN
cord-265941-eff4le0g	513	1	HIV-1	HIV-1	NNP
cord-265941-eff4le0g	513	2	protease	protease	NN
cord-265941-eff4le0g	513	3	cleaves	cleave	VBZ
cord-265941-eff4le0g	513	4	the	the	DT
cord-265941-eff4le0g	513	5	serine	serine	NN
cord-265941-eff4le0g	513	6	-	-	HYPH
cord-265941-eff4le0g	513	7	threonine	threonine	NN
cord-265941-eff4le0g	513	8	kinases	kinase	NNS
cord-265941-eff4le0g	513	9	RIPK1	ripk1	JJ
cord-265941-eff4le0g	513	10	and	and	CC
cord-265941-eff4le0g	513	11	RIPK2	ripk2	XX
cord-265941-eff4le0g	514	1	Dysfunctional	dysfunctional	JJ
cord-265941-eff4le0g	514	2	HIV	HIV	NNP
cord-265941-eff4le0g	514	3	-	-	HYPH
cord-265941-eff4le0g	514	4	specific	specific	JJ
cord-265941-eff4le0g	514	5	CD8	CD8	NNP
cord-265941-eff4le0g	514	6	+	+	CC
cord-265941-eff4le0g	514	7	T	t	NN
cord-265941-eff4le0g	514	8	cell	cell	NN
cord-265941-eff4le0g	514	9	proliferation	proliferation	NN
cord-265941-eff4le0g	514	10	is	be	VBZ
cord-265941-eff4le0g	514	11	associated	associate	VBN
cord-265941-eff4le0g	514	12	with	with	IN
cord-265941-eff4le0g	514	13	increased	increase	VBN
cord-265941-eff4le0g	514	14	caspase-8	caspase-8	JJ
cord-265941-eff4le0g	514	15	activity	activity	NN
cord-265941-eff4le0g	514	16	and	and	CC
cord-265941-eff4le0g	514	17	mediated	mediate	VBN
cord-265941-eff4le0g	514	18	by	by	IN
cord-265941-eff4le0g	514	19	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	514	20	Coxsackievirus	Coxsackievirus	NNP
cord-265941-eff4le0g	514	21	A6	A6	NNP
cord-265941-eff4le0g	514	22	induces	induce	VBZ
cord-265941-eff4le0g	514	23	necroptosis	necroptosis	NN
cord-265941-eff4le0g	514	24	for	for	IN
cord-265941-eff4le0g	514	25	viral	viral	JJ
cord-265941-eff4le0g	514	26	production	production	NN
cord-265941-eff4le0g	514	27	Advances	advance	NNS
cord-265941-eff4le0g	514	28	in	in	IN
cord-265941-eff4le0g	514	29	understanding	understand	VBG
cord-265941-eff4le0g	514	30	respiratory	respiratory	JJ
cord-265941-eff4le0g	514	31	syncytial	syncytial	JJ
cord-265941-eff4le0g	514	32	virus	virus	NN
cord-265941-eff4le0g	514	33	infection	infection	NN
cord-265941-eff4le0g	514	34	in	in	IN
cord-265941-eff4le0g	514	35	airway	airway	NN
cord-265941-eff4le0g	514	36	epithelial	epithelial	JJ
cord-265941-eff4le0g	514	37	cells	cell	NNS
cord-265941-eff4le0g	514	38	and	and	CC
cord-265941-eff4le0g	514	39	consequential	consequential	JJ
cord-265941-eff4le0g	514	40	effects	effect	NNS
cord-265941-eff4le0g	514	41	on	on	IN
cord-265941-eff4le0g	514	42	the	the	DT
cord-265941-eff4le0g	514	43	immune	immune	JJ
cord-265941-eff4le0g	514	44	response	response	NN
cord-265941-eff4le0g	514	45	RSV	RSV	NNP
cord-265941-eff4le0g	514	46	infection	infection	NN
cord-265941-eff4le0g	514	47	promotes	promote	VBZ
cord-265941-eff4le0g	514	48	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	514	49	and	and	CC
cord-265941-eff4le0g	514	50	HMGB1	HMGB1	NNP
cord-265941-eff4le0g	515	1	release	release	NN
cord-265941-eff4le0g	515	2	by	by	IN
cord-265941-eff4le0g	515	3	airway	airway	NN
cord-265941-eff4le0g	515	4	epithelial	epithelial	JJ
cord-265941-eff4le0g	515	5	cells	cell	NNS
cord-265941-eff4le0g	515	6	Respiratory	respiratory	JJ
cord-265941-eff4le0g	515	7	Syncytial	Syncytial	NNP
cord-265941-eff4le0g	515	8	Virus	Virus	NNP
cord-265941-eff4le0g	515	9	induces	induce	VBZ
cord-265941-eff4le0g	515	10	the	the	DT
cord-265941-eff4le0g	515	11	classical	classical	JJ
cord-265941-eff4le0g	515	12	ROS	ROS	NNP
cord-265941-eff4le0g	515	13	-	-	HYPH
cord-265941-eff4le0g	515	14	dependent	dependent	JJ
cord-265941-eff4le0g	515	15	NETosis	netosis	NN
cord-265941-eff4le0g	515	16	through	through	IN
cord-265941-eff4le0g	515	17	PAD-4	PAD-4	NNP
cord-265941-eff4le0g	515	18	and	and	CC
cord-265941-eff4le0g	515	19	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	515	20	pathways	pathway	NNS
cord-265941-eff4le0g	515	21	activation	activation	NN
cord-265941-eff4le0g	516	1	A	a	DT
cord-265941-eff4le0g	516	2	SARS	SARS	NNP
cord-265941-eff4le0g	516	3	-	-	HYPH
cord-265941-eff4le0g	516	4	CoV-2	CoV-2	NNP
cord-265941-eff4le0g	516	5	protein	protein	NN
cord-265941-eff4le0g	516	6	interaction	interaction	NN
cord-265941-eff4le0g	516	7	map	map	NN
cord-265941-eff4le0g	516	8	reveals	reveal	VBZ
cord-265941-eff4le0g	516	9	targets	target	NNS
cord-265941-eff4le0g	516	10	for	for	IN
cord-265941-eff4le0g	516	11	drug	drug	NN
cord-265941-eff4le0g	516	12	repurposing	repurposing	NN
cord-265941-eff4le0g	517	1	SARS	SARS	NNP
cord-265941-eff4le0g	517	2	-	-	HYPH
cord-265941-eff4le0g	517	3	Coronavirus	Coronavirus	NNP
cord-265941-eff4le0g	517	4	Open	Open	NNP
cord-265941-eff4le0g	518	1	Reading	read	VBG
cord-265941-eff4le0g	518	2	Frame-3a	Frame-3a	NNP
cord-265941-eff4le0g	518	3	drives	drive	NNS
cord-265941-eff4le0g	519	1	multimodal	multimodal	JJ
cord-265941-eff4le0g	519	2	necrotic	necrotic	JJ
cord-265941-eff4le0g	519	3	cell	cell	NN
cord-265941-eff4le0g	519	4	death	death	NN
cord-265941-eff4le0g	519	5	Severe	severe	JJ
cord-265941-eff4le0g	520	1	acute	acute	JJ
cord-265941-eff4le0g	520	2	respiratory	respiratory	JJ
cord-265941-eff4le0g	520	3	syndrome	syndrome	NN
cord-265941-eff4le0g	520	4	-	-	HYPH
cord-265941-eff4le0g	520	5	associated	associate	VBN
cord-265941-eff4le0g	520	6	coronavirus	coronavirus	NN
cord-265941-eff4le0g	521	1	3a	3a	NNP
cord-265941-eff4le0g	521	2	protein	protein	NNP
cord-265941-eff4le0g	521	3	forms	form	VBZ
cord-265941-eff4le0g	521	4	an	an	DT
cord-265941-eff4le0g	521	5	ion	ion	NN
cord-265941-eff4le0g	521	6	channel	channel	NN
cord-265941-eff4le0g	521	7	and	and	CC
cord-265941-eff4le0g	521	8	modulates	modulate	VBZ
cord-265941-eff4le0g	521	9	virus	virus	NN
cord-265941-eff4le0g	521	10	release	release	NN
cord-265941-eff4le0g	521	11	Role	role	NN
cord-265941-eff4le0g	521	12	of	of	IN
cord-265941-eff4le0g	521	13	severe	severe	JJ
cord-265941-eff4le0g	521	14	acute	acute	JJ
cord-265941-eff4le0g	521	15	respiratory	respiratory	JJ
cord-265941-eff4le0g	521	16	syndrome	syndrome	NN
cord-265941-eff4le0g	521	17	coronavirus	coronavirus	NN
cord-265941-eff4le0g	521	18	viroporins	viroporins	NNP
cord-265941-eff4le0g	521	19	e	e	NNP
cord-265941-eff4le0g	521	20	,	,	,
cord-265941-eff4le0g	521	21	3a	3a	NNP
cord-265941-eff4le0g	521	22	,	,	,
cord-265941-eff4le0g	521	23	and	and	CC
cord-265941-eff4le0g	521	24	8a	8a	NN
cord-265941-eff4le0g	521	25	in	in	IN
cord-265941-eff4le0g	521	26	replication	replication	NN
cord-265941-eff4le0g	521	27	and	and	CC
cord-265941-eff4le0g	521	28	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	522	1	EspL	EspL	NNP
cord-265941-eff4le0g	522	2	is	be	VBZ
cord-265941-eff4le0g	522	3	a	a	DT
cord-265941-eff4le0g	522	4	bacterial	bacterial	JJ
cord-265941-eff4le0g	522	5	cysteine	cysteine	NN
cord-265941-eff4le0g	522	6	protease	protease	NN
cord-265941-eff4le0g	522	7	effector	effector	NN
cord-265941-eff4le0g	522	8	that	that	WDT
cord-265941-eff4le0g	522	9	cleaves	cleave	VBZ
cord-265941-eff4le0g	522	10	RHIM	rhim	NN
cord-265941-eff4le0g	522	11	proteins	protein	NNS
cord-265941-eff4le0g	522	12	to	to	TO
cord-265941-eff4le0g	522	13	block	block	VB
cord-265941-eff4le0g	522	14	necroptosis	necroptosis	NN
cord-265941-eff4le0g	522	15	and	and	CC
cord-265941-eff4le0g	522	16	inflammation	inflammation	NN
cord-265941-eff4le0g	522	17	Toxin	toxin	NN
cord-265941-eff4le0g	522	18	-	-	HYPH
cord-265941-eff4le0g	522	19	induced	induce	VBN
cord-265941-eff4le0g	522	20	necroptosis	necroptosis	NN
cord-265941-eff4le0g	523	1	is	be	VBZ
cord-265941-eff4le0g	523	2	a	a	DT
cord-265941-eff4le0g	523	3	major	major	JJ
cord-265941-eff4le0g	523	4	mechanism	mechanism	NN
cord-265941-eff4le0g	523	5	of	of	IN
cord-265941-eff4le0g	523	6	Staphylococcus	Staphylococcus	NNP
cord-265941-eff4le0g	523	7	aureus	aureus	NN
cord-265941-eff4le0g	523	8	lung	lung	NN
cord-265941-eff4le0g	523	9	damage	damage	NN
cord-265941-eff4le0g	523	10	Pore	pore	NN
cord-265941-eff4le0g	523	11	-	-	HYPH
cord-265941-eff4le0g	523	12	forming	form	VBG
cord-265941-eff4le0g	523	13	toxins	toxin	NNS
cord-265941-eff4le0g	523	14	induce	induce	VBP
cord-265941-eff4le0g	523	15	macrophage	macrophage	NN
cord-265941-eff4le0g	523	16	necroptosis	necroptosis	NN
cord-265941-eff4le0g	523	17	during	during	IN
cord-265941-eff4le0g	523	18	acute	acute	JJ
cord-265941-eff4le0g	523	19	bacterial	bacterial	JJ
cord-265941-eff4le0g	523	20	pneumonia	pneumonia	NN
cord-265941-eff4le0g	523	21	Necroptosis	Necroptosis	NNP
cord-265941-eff4le0g	523	22	promotes	promote	VBZ
cord-265941-eff4le0g	523	23	Staphylococcus	Staphylococcus	NNP
cord-265941-eff4le0g	523	24	aureus	aureus	NN
cord-265941-eff4le0g	523	25	clearance	clearance	NN
cord-265941-eff4le0g	523	26	by	by	IN
cord-265941-eff4le0g	523	27	inhibiting	inhibit	VBG
cord-265941-eff4le0g	523	28	excessive	excessive	JJ
cord-265941-eff4le0g	523	29	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	523	30	signaling	signaling	NN
cord-265941-eff4le0g	523	31	Type	type	NN
cord-265941-eff4le0g	524	1	I	-PRON-	PRP
cord-265941-eff4le0g	524	2	interferon	interferon	RB
cord-265941-eff4le0g	524	3	induces	induce	VBZ
cord-265941-eff4le0g	524	4	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	524	5	in	in	IN
cord-265941-eff4le0g	524	6	macrophages	macrophage	NNS
cord-265941-eff4le0g	524	7	during	during	IN
cord-265941-eff4le0g	524	8	infection	infection	NN
cord-265941-eff4le0g	524	9	with	with	IN
cord-265941-eff4le0g	524	10	Salmonella	Salmonella	NNP
cord-265941-eff4le0g	524	11	enterica	enterica	NNP
cord-265941-eff4le0g	525	1	serovar	serovar	NNP
cord-265941-eff4le0g	526	1	Typhimurium	Typhimurium	NNP
cord-265941-eff4le0g	526	2	Salmonella	Salmonella	NNP
cord-265941-eff4le0g	526	3	-	-	HYPH
cord-265941-eff4le0g	526	4	induced	induce	VBN
cord-265941-eff4le0g	526	5	miR-155	miR-155	NNP
cord-265941-eff4le0g	526	6	enhances	enhance	VBZ
cord-265941-eff4le0g	526	7	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	526	8	death	death	NN
cord-265941-eff4le0g	526	9	in	in	IN
cord-265941-eff4le0g	526	10	macrophage	macrophage	NN
cord-265941-eff4le0g	526	11	cells	cell	NNS
cord-265941-eff4le0g	526	12	via	via	IN
cord-265941-eff4le0g	526	13	targeting	target	VBG
cord-265941-eff4le0g	526	14	RIP1/3	RIP1/3	.
cord-265941-eff4le0g	527	1	Susceptibility	susceptibility	NN
cord-265941-eff4le0g	527	2	of	of	IN
cord-265941-eff4le0g	527	3	Mycobacterium	Mycobacterium	NNP
cord-265941-eff4le0g	527	4	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	527	5	-	-	HYPH
cord-265941-eff4le0g	527	6	infected	infect	VBN
cord-265941-eff4le0g	527	7	host	host	NN
cord-265941-eff4le0g	527	8	cells	cell	NNS
cord-265941-eff4le0g	527	9	to	to	IN
cord-265941-eff4le0g	527	10	phospho	phospho	NN
cord-265941-eff4le0g	527	11	-	-	HYPH
cord-265941-eff4le0g	527	12	MLKL	MLKL	NNP
cord-265941-eff4le0g	527	13	driven	drive	VBN
cord-265941-eff4le0g	527	14	necroptosis	necroptosis	NN
cord-265941-eff4le0g	527	15	is	be	VBZ
cord-265941-eff4le0g	527	16	dependent	dependent	JJ
cord-265941-eff4le0g	527	17	on	on	IN
cord-265941-eff4le0g	527	18	cell	cell	NN
cord-265941-eff4le0g	527	19	type	type	NN
cord-265941-eff4le0g	527	20	and	and	CC
cord-265941-eff4le0g	527	21	presence	presence	NN
cord-265941-eff4le0g	527	22	of	of	IN
cord-265941-eff4le0g	527	23	TNFα	TNFα	NNP
cord-265941-eff4le0g	527	24	Bcl	Bcl	NNP
cord-265941-eff4le0g	527	25	-	-	HYPH
cord-265941-eff4le0g	527	26	x(L	x(L	NFP
cord-265941-eff4le0g	527	27	)	)	-RRB-
cord-265941-eff4le0g	527	28	mediates	mediate	VBZ
cord-265941-eff4le0g	527	29	RIPK3-dependent	RIPK3-dependent	:
cord-265941-eff4le0g	527	30	necrosis	necrosis	NN
cord-265941-eff4le0g	527	31	in	in	IN
cord-265941-eff4le0g	527	32	M.	M.	NNP
cord-265941-eff4le0g	527	33	Tuberculosisinfected	Tuberculosisinfected	NNP
cord-265941-eff4le0g	527	34	macrophages	macrophage	NNS
cord-265941-eff4le0g	528	1	Necroptotic	necroptotic	JJ
cord-265941-eff4le0g	528	2	signaling	signaling	NN
cord-265941-eff4le0g	528	3	is	be	VBZ
cord-265941-eff4le0g	528	4	primed	prime	VBN
cord-265941-eff4le0g	528	5	in	in	IN
cord-265941-eff4le0g	528	6	Mycobacterium	Mycobacterium	NNP
cord-265941-eff4le0g	528	7	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	528	8	-	-	HYPH
cord-265941-eff4le0g	528	9	infected	infect	VBN
cord-265941-eff4le0g	528	10	macrophages	macrophage	NNS
cord-265941-eff4le0g	528	11	,	,	,
cord-265941-eff4le0g	528	12	but	but	CC
cord-265941-eff4le0g	528	13	its	-PRON-	PRP$
cord-265941-eff4le0g	528	14	pathophysiological	pathophysiological	JJ
cord-265941-eff4le0g	528	15	consequence	consequence	NN
cord-265941-eff4le0g	528	16	in	in	IN
cord-265941-eff4le0g	528	17	disease	disease	NN
cord-265941-eff4le0g	528	18	is	be	VBZ
cord-265941-eff4le0g	528	19	restricted	restrict	VBN
cord-265941-eff4le0g	528	20	Is	be	VBZ
cord-265941-eff4le0g	528	21	receptor	receptor	NN
cord-265941-eff4le0g	528	22	-	-	HYPH
cord-265941-eff4le0g	528	23	interacting	interact	VBG
cord-265941-eff4le0g	528	24	protein	protein	NN
cord-265941-eff4le0g	528	25	kinase	kinase	VBD
cord-265941-eff4le0g	528	26	3	3	CD
cord-265941-eff4le0g	528	27	a	a	DT
cord-265941-eff4le0g	528	28	viable	viable	JJ
cord-265941-eff4le0g	528	29	therapeutic	therapeutic	JJ
cord-265941-eff4le0g	528	30	target	target	NN
cord-265941-eff4le0g	528	31	for	for	IN
cord-265941-eff4le0g	528	32	Mycobacterium	Mycobacterium	NNP
cord-265941-eff4le0g	528	33	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	528	34	infection	infection	NN
cord-265941-eff4le0g	528	35	?	?	.
cord-265941-eff4le0g	529	1	Toward	toward	IN
cord-265941-eff4le0g	529	2	targeting	target	VBG
cord-265941-eff4le0g	529	3	inflammasomes	inflammasome	NNS
cord-265941-eff4le0g	529	4	:	:	:
cord-265941-eff4le0g	529	5	insights	insight	NNS
cord-265941-eff4le0g	529	6	into	into	IN
cord-265941-eff4le0g	529	7	their	-PRON-	PRP$
cord-265941-eff4le0g	529	8	regulation	regulation	NN
cord-265941-eff4le0g	529	9	and	and	CC
cord-265941-eff4le0g	529	10	activation	activation	NN
cord-265941-eff4le0g	529	11	Human	human	NN
cord-265941-eff4le0g	529	12	monocytes	monocyte	NNS
cord-265941-eff4le0g	529	13	engage	engage	VBP
cord-265941-eff4le0g	529	14	an	an	DT
cord-265941-eff4le0g	529	15	alternative	alternative	JJ
cord-265941-eff4le0g	529	16	inflammasome	inflammasome	NN
cord-265941-eff4le0g	529	17	pathway	pathway	NN
cord-265941-eff4le0g	529	18	Caspase-8	Caspase-8	NNP
cord-265941-eff4le0g	529	19	blocks	block	NNS
cord-265941-eff4le0g	529	20	kinase	kinase	NN
cord-265941-eff4le0g	529	21	RIPK3-Mediated	RIPK3-Mediated	NNP
cord-265941-eff4le0g	529	22	activation	activation	NN
cord-265941-eff4le0g	529	23	of	of	IN
cord-265941-eff4le0g	529	24	the	the	DT
cord-265941-eff4le0g	529	25	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	529	26	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	530	1	RIPK3	RIPK3	NNP
cord-265941-eff4le0g	530	2	promotes	promote	VBZ
cord-265941-eff4le0g	530	3	cell	cell	NN
cord-265941-eff4le0g	530	4	death	death	NN
cord-265941-eff4le0g	530	5	and	and	CC
cord-265941-eff4le0g	530	6	NLRP3	nlrp3	NN
cord-265941-eff4le0g	530	7	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	530	8	activation	activation	NN
cord-265941-eff4le0g	530	9	in	in	IN
cord-265941-eff4le0g	530	10	the	the	DT
cord-265941-eff4le0g	530	11	absence	absence	NN
cord-265941-eff4le0g	530	12	of	of	IN
cord-265941-eff4le0g	530	13	MLKL	MLKL	NNP
cord-265941-eff4le0g	530	14	Differential	Differential	NNP
cord-265941-eff4le0g	530	15	requirement	requirement	NN
cord-265941-eff4le0g	530	16	for	for	IN
cord-265941-eff4le0g	530	17	the	the	DT
cord-265941-eff4le0g	530	18	activation	activation	NN
cord-265941-eff4le0g	530	19	of	of	IN
cord-265941-eff4le0g	530	20	the	the	DT
cord-265941-eff4le0g	530	21	inflammasome	inflammasome	NN
cord-265941-eff4le0g	530	22	for	for	IN
cord-265941-eff4le0g	530	23	processing	processing	NN
cord-265941-eff4le0g	530	24	and	and	CC
cord-265941-eff4le0g	530	25	release	release	NN
cord-265941-eff4le0g	530	26	of	of	IN
cord-265941-eff4le0g	530	27	IL-1beta	il-1beta	NN
cord-265941-eff4le0g	530	28	in	in	IN
cord-265941-eff4le0g	530	29	monocytes	monocyte	NNS
cord-265941-eff4le0g	530	30	and	and	CC
cord-265941-eff4le0g	530	31	macrophages	macrophage	NNS
cord-265941-eff4le0g	530	32	Vesicular	Vesicular	NNP
cord-265941-eff4le0g	530	33	stomatitis	stomatitis	NN
cord-265941-eff4le0g	530	34	virus	virus	NN
cord-265941-eff4le0g	530	35	transmission	transmission	NN
cord-265941-eff4le0g	530	36	:	:	:
cord-265941-eff4le0g	530	37	a	a	DT
cord-265941-eff4le0g	530	38	comparison	comparison	NN
cord-265941-eff4le0g	530	39	of	of	IN
cord-265941-eff4le0g	530	40	incriminated	incriminate	VBN
cord-265941-eff4le0g	530	41	vectors	vector	NNS
cord-265941-eff4le0g	530	42	RNA	RNA	NNP
cord-265941-eff4le0g	530	43	viruses	virus	NNS
cord-265941-eff4le0g	530	44	promote	promote	VBP
cord-265941-eff4le0g	530	45	activation	activation	NN
cord-265941-eff4le0g	530	46	of	of	IN
cord-265941-eff4le0g	530	47	the	the	DT
cord-265941-eff4le0g	530	48	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	530	49	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	530	50	through	through	IN
cord-265941-eff4le0g	530	51	a	a	DT
cord-265941-eff4le0g	530	52	RIP1-RIP3-DRP1	rip1-rip3-drp1	NN
cord-265941-eff4le0g	531	1	signaling	signal	VBG
cord-265941-eff4le0g	531	2	pathway	pathway	NN
cord-265941-eff4le0g	531	3	Platelets	platelet	NNS
cord-265941-eff4le0g	531	4	mediate	mediate	VBP
cord-265941-eff4le0g	531	5	increased	increase	VBN
cord-265941-eff4le0g	531	6	endothelium	endothelium	NN
cord-265941-eff4le0g	531	7	permeability	permeability	NN
cord-265941-eff4le0g	531	8	in	in	IN
cord-265941-eff4le0g	531	9	dengue	dengue	NN
cord-265941-eff4le0g	531	10	through	through	IN
cord-265941-eff4le0g	531	11	NLRP3-inflammasome	NLRP3-inflammasome	NNP
cord-265941-eff4le0g	531	12	activation	activation	NN
cord-265941-eff4le0g	532	1	Swine	Swine	NNP
cord-265941-eff4le0g	532	2	influenza	influenza	NN
cord-265941-eff4le0g	532	3	virus	virus	NN
cord-265941-eff4le0g	532	4	induces	induce	VBZ
cord-265941-eff4le0g	532	5	RIPK1/	RIPK1/	.
cord-265941-eff4le0g	533	1	DRP1-Mediated	drp1-mediated	JJ
cord-265941-eff4le0g	533	2	Interleukin-1	Interleukin-1	NNP
cord-265941-eff4le0g	534	1	Beta	beta	NN
cord-265941-eff4le0g	535	1	production	production	NN
cord-265941-eff4le0g	535	2	Caspase-8	Caspase-8	NNP
cord-265941-eff4le0g	535	3	scaffolding	scaffolding	NN
cord-265941-eff4le0g	535	4	function	function	NN
cord-265941-eff4le0g	535	5	and	and	CC
cord-265941-eff4le0g	535	6	MLKL	MLKL	NNP
cord-265941-eff4le0g	535	7	regulate	regulate	VBP
cord-265941-eff4le0g	535	8	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	535	9	inflammasome	inflammasome	NN
cord-265941-eff4le0g	535	10	activation	activation	NN
cord-265941-eff4le0g	535	11	downstream	downstream	RB
cord-265941-eff4le0g	535	12	of	of	IN
cord-265941-eff4le0g	535	13	TLR3	TLR3	NNP
cord-265941-eff4le0g	535	14	RNA	RNA	NNP
cord-265941-eff4le0g	535	15	viruses	virus	NNS
cord-265941-eff4le0g	535	16	promote	promote	VBP
cord-265941-eff4le0g	535	17	activation	activation	NN
cord-265941-eff4le0g	535	18	of	of	IN
cord-265941-eff4le0g	535	19	the	the	DT
cord-265941-eff4le0g	535	20	NLRP3	NLRP3	NNP
cord-265941-eff4le0g	535	21	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	535	22	through	through	IN
cord-265941-eff4le0g	535	23	cytopathogenic	cytopathogenic	JJ
cord-265941-eff4le0g	535	24	effectinduced	effectinduced	NNP
cord-265941-eff4le0g	535	25	potassium	potassium	NN
cord-265941-eff4le0g	535	26	efflux	efflux	NN
cord-265941-eff4le0g	536	1	The	the	DT
cord-265941-eff4le0g	536	2	mitochondrial	mitochondrial	JJ
cord-265941-eff4le0g	536	3	phosphatase	phosphatase	NN
cord-265941-eff4le0g	537	1	PGAM5	PGAM5	NNP
cord-265941-eff4le0g	537	2	is	be	VBZ
cord-265941-eff4le0g	537	3	dispensable	dispensable	JJ
cord-265941-eff4le0g	537	4	for	for	IN
cord-265941-eff4le0g	537	5	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	537	6	but	but	CC
cord-265941-eff4le0g	537	7	promotes	promote	VBZ
cord-265941-eff4le0g	537	8	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	537	9	activation	activation	NN
cord-265941-eff4le0g	537	10	in	in	IN
cord-265941-eff4le0g	537	11	macrophages	macrophage	NNS
cord-265941-eff4le0g	537	12	Caspase-8	Caspase-8	NNP
cord-265941-eff4le0g	537	13	mediates	mediate	VBZ
cord-265941-eff4le0g	537	14	caspase-1	caspase-1	NNP
cord-265941-eff4le0g	537	15	processing	processing	NN
cord-265941-eff4le0g	537	16	and	and	CC
cord-265941-eff4le0g	537	17	innate	innate	JJ
cord-265941-eff4le0g	537	18	immune	immune	JJ
cord-265941-eff4le0g	537	19	defense	defense	NN
cord-265941-eff4le0g	537	20	in	in	IN
cord-265941-eff4le0g	537	21	response	response	NN
cord-265941-eff4le0g	537	22	to	to	IN
cord-265941-eff4le0g	537	23	bacterial	bacterial	JJ
cord-265941-eff4le0g	537	24	blockade	blockade	NN
cord-265941-eff4le0g	537	25	of	of	IN
cord-265941-eff4le0g	537	26	NF	nf	NN
cord-265941-eff4le0g	537	27	-	-	HYPH
cord-265941-eff4le0g	537	28	κB	κB	NNP
cord-265941-eff4le0g	537	29	and	and	CC
cord-265941-eff4le0g	537	30	MAPK	MAPK	NNP
cord-265941-eff4le0g	537	31	signaling	signal	VBG
cord-265941-eff4le0g	537	32	Pathogen	Pathogen	NNP
cord-265941-eff4le0g	537	33	blockade	blockade	NN
cord-265941-eff4le0g	537	34	of	of	IN
cord-265941-eff4le0g	537	35	TAK1	TAK1	NNP
cord-265941-eff4le0g	537	36	triggers	trigger	VBZ
cord-265941-eff4le0g	537	37	caspase-8-dependent	caspase-8-dependent	JJ
cord-265941-eff4le0g	537	38	cleavage	cleavage	NN
cord-265941-eff4le0g	537	39	of	of	IN
cord-265941-eff4le0g	537	40	gasdermin	gasdermin	NN
cord-265941-eff4le0g	537	41	D	D	NNP
cord-265941-eff4le0g	537	42	and	and	CC
cord-265941-eff4le0g	537	43	cell	cell	NN
cord-265941-eff4le0g	537	44	death	death	NN
cord-265941-eff4le0g	538	1	RICK	RICK	NNP
cord-265941-eff4le0g	538	2	/	/	SYM
cord-265941-eff4le0g	538	3	Rip2	Rip2	NNP
cord-265941-eff4le0g	538	4	/	/	SYM
cord-265941-eff4le0g	538	5	CARDIAK	CARDIAK	NNP
cord-265941-eff4le0g	538	6	mediates	mediate	VBZ
cord-265941-eff4le0g	538	7	signalling	signal	VBG
cord-265941-eff4le0g	538	8	for	for	IN
cord-265941-eff4le0g	538	9	receptors	receptor	NNS
cord-265941-eff4le0g	538	10	of	of	IN
cord-265941-eff4le0g	538	11	the	the	DT
cord-265941-eff4le0g	538	12	innate	innate	JJ
cord-265941-eff4le0g	538	13	and	and	CC
cord-265941-eff4le0g	538	14	adaptive	adaptive	JJ
cord-265941-eff4le0g	538	15	immune	immune	JJ
cord-265941-eff4le0g	538	16	systems	system	NNS
cord-265941-eff4le0g	538	17	RIP2	RIP2	NNP
cord-265941-eff4le0g	538	18	is	be	VBZ
cord-265941-eff4le0g	538	19	a	a	DT
cord-265941-eff4le0g	538	20	novel	novel	JJ
cord-265941-eff4le0g	538	21	NF	nf	NN
cord-265941-eff4le0g	538	22	-	-	HYPH
cord-265941-eff4le0g	538	23	kappaB	kappaB	NNP
cord-265941-eff4le0g	538	24	-	-	HYPH
cord-265941-eff4le0g	538	25	activating	activating	NN
cord-265941-eff4le0g	538	26	and	and	CC
cord-265941-eff4le0g	538	27	cell	cell	NN
cord-265941-eff4le0g	539	1	death	death	NN
cord-265941-eff4le0g	539	2	-	-	HYPH
cord-265941-eff4le0g	539	3	inducing	induce	VBG
cord-265941-eff4le0g	539	4	kinase	kinase	NN
cord-265941-eff4le0g	540	1	The	the	DT
cord-265941-eff4le0g	540	2	kinase	kinase	NN
cord-265941-eff4le0g	540	3	activity	activity	NN
cord-265941-eff4le0g	540	4	of	of	IN
cord-265941-eff4le0g	540	5	Rip2	Rip2	NNP
cord-265941-eff4le0g	540	6	determines	determine	VBZ
cord-265941-eff4le0g	540	7	its	-PRON-	PRP$
cord-265941-eff4le0g	540	8	stability	stability	NN
cord-265941-eff4le0g	540	9	and	and	CC
cord-265941-eff4le0g	540	10	consequently	consequently	RB
cord-265941-eff4le0g	540	11	Nod1-and	Nod1-and	NNP
cord-265941-eff4le0g	540	12	Nod2-mediated	nod2-mediated	JJ
cord-265941-eff4le0g	540	13	immune	immune	JJ
cord-265941-eff4le0g	540	14	responses	response	NNS
cord-265941-eff4le0g	541	1	RICK	RICK	NNP
cord-265941-eff4le0g	541	2	/	/	SYM
cord-265941-eff4le0g	541	3	RIP2	RIP2	NNP
cord-265941-eff4le0g	541	4	mediates	mediate	VBZ
cord-265941-eff4le0g	541	5	innate	innate	JJ
cord-265941-eff4le0g	541	6	immune	immune	JJ
cord-265941-eff4le0g	541	7	responses	response	NNS
cord-265941-eff4le0g	541	8	induced	induce	VBN
cord-265941-eff4le0g	541	9	through	through	IN
cord-265941-eff4le0g	541	10	Nod1	Nod1	NNP
cord-265941-eff4le0g	541	11	and	and	CC
cord-265941-eff4le0g	541	12	Nod2	Nod2	NNP
cord-265941-eff4le0g	541	13	but	but	CC
cord-265941-eff4le0g	541	14	not	not	RB
cord-265941-eff4le0g	541	15	TLRs	tlr	VBZ
cord-265941-eff4le0g	541	16	An	an	DT
cord-265941-eff4le0g	541	17	essential	essential	JJ
cord-265941-eff4le0g	541	18	role	role	NN
cord-265941-eff4le0g	541	19	for	for	IN
cord-265941-eff4le0g	541	20	NOD1	NOD1	NNP
cord-265941-eff4le0g	541	21	in	in	IN
cord-265941-eff4le0g	541	22	host	host	NN
cord-265941-eff4le0g	541	23	recognition	recognition	NN
cord-265941-eff4le0g	541	24	of	of	IN
cord-265941-eff4le0g	541	25	bacterial	bacterial	JJ
cord-265941-eff4le0g	541	26	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	541	27	containing	contain	VBG
cord-265941-eff4le0g	541	28	diaminopimelic	diaminopimelic	JJ
cord-265941-eff4le0g	541	29	acid	acid	NN
cord-265941-eff4le0g	541	30	Nod1	Nod1	NNP
cord-265941-eff4le0g	542	1	detects	detect	VBZ
cord-265941-eff4le0g	542	2	a	a	DT
cord-265941-eff4le0g	542	3	unique	unique	JJ
cord-265941-eff4le0g	542	4	muropeptide	muropeptide	NN
cord-265941-eff4le0g	542	5	from	from	IN
cord-265941-eff4le0g	542	6	gram	gram	NN
cord-265941-eff4le0g	542	7	-	-	HYPH
cord-265941-eff4le0g	542	8	negative	negative	JJ
cord-265941-eff4le0g	542	9	bacterial	bacterial	JJ
cord-265941-eff4le0g	542	10	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	542	11	Nod2	Nod2	NNP
cord-265941-eff4le0g	542	12	is	be	VBZ
cord-265941-eff4le0g	542	13	a	a	DT
cord-265941-eff4le0g	542	14	general	general	JJ
cord-265941-eff4le0g	542	15	sensor	sensor	NN
cord-265941-eff4le0g	542	16	of	of	IN
cord-265941-eff4le0g	542	17	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	542	18	through	through	IN
cord-265941-eff4le0g	542	19	Muramyl	Muramyl	NNP
cord-265941-eff4le0g	542	20	Dipeptide	Dipeptide	NNP
cord-265941-eff4le0g	542	21	(	(	-LRB-
cord-265941-eff4le0g	542	22	MDP	MDP	NNP
cord-265941-eff4le0g	542	23	)	)	-RRB-
cord-265941-eff4le0g	542	24	detection	detection	NN
cord-265941-eff4le0g	542	25	Host	Host	NNP
cord-265941-eff4le0g	542	26	recognition	recognition	NN
cord-265941-eff4le0g	542	27	of	of	IN
cord-265941-eff4le0g	542	28	bacterial	bacterial	JJ
cord-265941-eff4le0g	542	29	muramyl	muramyl	NNP
cord-265941-eff4le0g	542	30	dipeptide	dipeptide	NNP
cord-265941-eff4le0g	542	31	mediated	mediate	VBN
cord-265941-eff4le0g	542	32	through	through	IN
cord-265941-eff4le0g	542	33	NOD2	NOD2	NNPS
cord-265941-eff4le0g	542	34	.	.	.
cord-265941-eff4le0g	543	1	Implications	implication	NNS
cord-265941-eff4le0g	543	2	for	for	IN
cord-265941-eff4le0g	543	3	Crohn	Crohn	NNP
cord-265941-eff4le0g	543	4	's	's	POS
cord-265941-eff4le0g	543	5	disease	disease	NN
cord-265941-eff4le0g	543	6	Type	Type	NNP
cord-265941-eff4le0g	543	7	IV	IV	NNP
cord-265941-eff4le0g	543	8	secretion	secretion	NN
cord-265941-eff4le0g	543	9	-	-	HYPH
cord-265941-eff4le0g	543	10	dependent	dependent	JJ
cord-265941-eff4le0g	543	11	activation	activation	NN
cord-265941-eff4le0g	543	12	of	of	IN
cord-265941-eff4le0g	543	13	host	host	NN
cord-265941-eff4le0g	543	14	MAP	map	NN
cord-265941-eff4le0g	543	15	kinases	kinase	NNS
cord-265941-eff4le0g	543	16	induces	induce	VBZ
cord-265941-eff4le0g	543	17	an	an	DT
cord-265941-eff4le0g	543	18	increased	increase	VBN
cord-265941-eff4le0g	543	19	proinflammatory	proinflammatory	JJ
cord-265941-eff4le0g	543	20	cytokine	cytokine	NN
cord-265941-eff4le0g	543	21	response	response	NN
cord-265941-eff4le0g	543	22	to	to	IN
cord-265941-eff4le0g	543	23	Legionella	Legionella	NNP
cord-265941-eff4le0g	543	24	pneumophila	pneumophila	NN
cord-265941-eff4le0g	544	1	A	a	DT
cord-265941-eff4le0g	545	1	RIPK2	ripk2	XX
cord-265941-eff4le0g	546	1	inhibitor	inhibitor	NN
cord-265941-eff4le0g	546	2	delays	delay	NNS
cord-265941-eff4le0g	546	3	NOD	nod	VBP
cord-265941-eff4le0g	546	4	signalling	signal	VBG
cord-265941-eff4le0g	546	5	events	event	NNS
cord-265941-eff4le0g	546	6	yet	yet	RB
cord-265941-eff4le0g	546	7	prevents	prevent	VBZ
cord-265941-eff4le0g	547	1	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	547	2	cytokine	cytokine	NN
cord-265941-eff4le0g	547	3	production	production	NN
cord-265941-eff4le0g	547	4	NOD2	NOD2	NNPS
cord-265941-eff4le0g	547	5	,	,	,
cord-265941-eff4le0g	547	6	RIP2	RIP2	NNP
cord-265941-eff4le0g	547	7	and	and	CC
cord-265941-eff4le0g	547	8	IRF5	IRF5	NNP
cord-265941-eff4le0g	547	9	play	play	VBP
cord-265941-eff4le0g	547	10	a	a	DT
cord-265941-eff4le0g	547	11	critical	critical	JJ
cord-265941-eff4le0g	547	12	role	role	NN
cord-265941-eff4le0g	547	13	in	in	IN
cord-265941-eff4le0g	547	14	the	the	DT
cord-265941-eff4le0g	547	15	type	type	NN
cord-265941-eff4le0g	548	1	I	-PRON-	PRP
cord-265941-eff4le0g	549	1	interferon	interferon	NN
cord-265941-eff4le0g	549	2	response	response	NN
cord-265941-eff4le0g	549	3	to	to	IN
cord-265941-eff4le0g	549	4	Mycobacterium	Mycobacterium	NNP
cord-265941-eff4le0g	549	5	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	549	6	ATG16L1	ATG16L1	NNPS
cord-265941-eff4le0g	549	7	and	and	CC
cord-265941-eff4le0g	549	8	NOD2	NOD2	NNPS
cord-265941-eff4le0g	549	9	interact	interact	VBP
cord-265941-eff4le0g	549	10	in	in	IN
cord-265941-eff4le0g	549	11	an	an	DT
cord-265941-eff4le0g	549	12	autophagy	autophagy	NN
cord-265941-eff4le0g	549	13	-	-	HYPH
cord-265941-eff4le0g	549	14	dependent	dependent	JJ
cord-265941-eff4le0g	549	15	antibacterial	antibacterial	JJ
cord-265941-eff4le0g	549	16	pathway	pathway	NN
cord-265941-eff4le0g	549	17	implicated	implicate	VBN
cord-265941-eff4le0g	549	18	in	in	IN
cord-265941-eff4le0g	549	19	Crohn	Crohn	NNP
cord-265941-eff4le0g	549	20	's	's	POS
cord-265941-eff4le0g	549	21	disease	disease	NN
cord-265941-eff4le0g	549	22	pathogenesis	pathogenesis	NN
cord-265941-eff4le0g	550	1	The	the	DT
cord-265941-eff4le0g	550	2	immune	immune	JJ
cord-265941-eff4le0g	550	3	receptor	receptor	NN
cord-265941-eff4le0g	550	4	NOD1	NOD1	NNP
cord-265941-eff4le0g	550	5	and	and	CC
cord-265941-eff4le0g	550	6	kinase	kinase	VBD
cord-265941-eff4le0g	550	7	RIP2	RIP2	NNP
cord-265941-eff4le0g	550	8	interact	interact	VBP
cord-265941-eff4le0g	550	9	with	with	IN
cord-265941-eff4le0g	550	10	bacterial	bacterial	JJ
cord-265941-eff4le0g	550	11	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	550	12	on	on	IN
cord-265941-eff4le0g	550	13	early	early	JJ
cord-265941-eff4le0g	550	14	endosomes	endosome	NNS
cord-265941-eff4le0g	550	15	to	to	TO
cord-265941-eff4le0g	550	16	promote	promote	VB
cord-265941-eff4le0g	550	17	autophagy	autophagy	NN
cord-265941-eff4le0g	550	18	and	and	CC
cord-265941-eff4le0g	550	19	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	550	20	signaling	signal	VBG
cord-265941-eff4le0g	550	21	The	the	DT
cord-265941-eff4le0g	550	22	protein	protein	NN
cord-265941-eff4le0g	550	23	ATG16L1	atg16l1	NN
cord-265941-eff4le0g	550	24	suppresses	suppress	VBZ
cord-265941-eff4le0g	550	25	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	550	26	cytokines	cytokine	NNS
cord-265941-eff4le0g	550	27	induced	induce	VBN
cord-265941-eff4le0g	550	28	by	by	IN
cord-265941-eff4le0g	550	29	the	the	DT
cord-265941-eff4le0g	550	30	intracellular	intracellular	JJ
cord-265941-eff4le0g	550	31	sensors	sensor	NNS
cord-265941-eff4le0g	550	32	Nod1	Nod1	NNP
cord-265941-eff4le0g	550	33	and	and	CC
cord-265941-eff4le0g	550	34	Nod2	Nod2	NNP
cord-265941-eff4le0g	550	35	in	in	IN
cord-265941-eff4le0g	550	36	an	an	DT
cord-265941-eff4le0g	550	37	autophagy	autophagy	NN
cord-265941-eff4le0g	550	38	-	-	HYPH
cord-265941-eff4le0g	550	39	independent	independent	JJ
cord-265941-eff4le0g	550	40	manner	manner	NN
cord-265941-eff4le0g	550	41	Involvement	involvement	NN
cord-265941-eff4le0g	550	42	of	of	IN
cord-265941-eff4le0g	550	43	receptor	receptor	NN
cord-265941-eff4le0g	550	44	-	-	HYPH
cord-265941-eff4le0g	550	45	interacting	interact	VBG
cord-265941-eff4le0g	550	46	protein	protein	NN
cord-265941-eff4le0g	550	47	2	2	CD
cord-265941-eff4le0g	550	48	in	in	IN
cord-265941-eff4le0g	550	49	innate	innate	JJ
cord-265941-eff4le0g	550	50	and	and	CC
cord-265941-eff4le0g	550	51	adaptive	adaptive	JJ
cord-265941-eff4le0g	550	52	immune	immune	JJ
cord-265941-eff4le0g	550	53	responses	response	NNS
cord-265941-eff4le0g	551	1	RIPK2	ripk2	XX
cord-265941-eff4le0g	552	1	polymorphisms	polymorphism	NNS
cord-265941-eff4le0g	552	2	and	and	CC
cord-265941-eff4le0g	552	3	susceptibility	susceptibility	NN
cord-265941-eff4le0g	552	4	to	to	IN
cord-265941-eff4le0g	552	5	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	552	6	in	in	IN
cord-265941-eff4le0g	552	7	a	a	DT
cord-265941-eff4le0g	552	8	Western	western	JJ
cord-265941-eff4le0g	552	9	Chinese	chinese	JJ
cord-265941-eff4le0g	552	10	Han	Han	NNP
cord-265941-eff4le0g	552	11	population	population	NN
cord-265941-eff4le0g	552	12	Genetic	genetic	JJ
cord-265941-eff4le0g	552	13	dissection	dissection	NN
cord-265941-eff4le0g	552	14	of	of	IN
cord-265941-eff4le0g	552	15	immunity	immunity	NN
cord-265941-eff4le0g	552	16	to	to	IN
cord-265941-eff4le0g	552	17	mycobacteria	mycobacterium	NNS
cord-265941-eff4le0g	552	18	:	:	:
cord-265941-eff4le0g	552	19	the	the	DT
cord-265941-eff4le0g	552	20	human	human	JJ
cord-265941-eff4le0g	552	21	model	model	NN
cord-265941-eff4le0g	552	22	Control	Control	NNP
cord-265941-eff4le0g	552	23	of	of	IN
cord-265941-eff4le0g	552	24	human	human	JJ
cord-265941-eff4le0g	552	25	host	host	NN
cord-265941-eff4le0g	552	26	immunity	immunity	NN
cord-265941-eff4le0g	552	27	to	to	IN
cord-265941-eff4le0g	552	28	mycobacteria	mycobacterium	NNS
cord-265941-eff4le0g	552	29	Streptococcus	streptococcus	NN
cord-265941-eff4le0g	552	30	pneumoniae	pneumoniae	NN
cord-265941-eff4le0g	552	31	:	:	:
cord-265941-eff4le0g	552	32	transmission	transmission	NN
cord-265941-eff4le0g	552	33	,	,	,
cord-265941-eff4le0g	552	34	colonization	colonization	NN
cord-265941-eff4le0g	552	35	and	and	CC
cord-265941-eff4le0g	552	36	invasion	invasion	NN
cord-265941-eff4le0g	553	1	The	the	DT
cord-265941-eff4le0g	553	2	TLR2-MyD88-NOD2-RIPK2	tlr2-myd88-nod2-ripk2	XX
cord-265941-eff4le0g	554	1	signalling	signal	VBG
cord-265941-eff4le0g	554	2	axis	axis	NN
cord-265941-eff4le0g	554	3	regulates	regulate	VBZ
cord-265941-eff4le0g	554	4	a	a	DT
cord-265941-eff4le0g	554	5	balanced	balanced	JJ
cord-265941-eff4le0g	554	6	pro	pro	JJ
cord-265941-eff4le0g	554	7	-	-	JJ
cord-265941-eff4le0g	554	8	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	554	9	and	and	CC
cord-265941-eff4le0g	554	10	IL-10-mediated	il-10-mediated	JJ
cord-265941-eff4le0g	554	11	antiinflammatory	antiinflammatory	JJ
cord-265941-eff4le0g	554	12	cytokine	cytokine	NN
cord-265941-eff4le0g	554	13	response	response	NN
cord-265941-eff4le0g	554	14	to	to	IN
cord-265941-eff4le0g	554	15	Gram	gram	NN
cord-265941-eff4le0g	554	16	-	-	HYPH
cord-265941-eff4le0g	554	17	positive	positive	JJ
cord-265941-eff4le0g	554	18	cell	cell	NN
cord-265941-eff4le0g	554	19	walls	wall	NNS
cord-265941-eff4le0g	554	20	Cutting	cut	VBG
cord-265941-eff4le0g	554	21	edge	edge	NN
cord-265941-eff4le0g	554	22	:	:	:
cord-265941-eff4le0g	554	23	recognition	recognition	NN
cord-265941-eff4le0g	554	24	of	of	IN
cord-265941-eff4le0g	554	25	Gram	gram	NN
cord-265941-eff4le0g	554	26	-	-	HYPH
cord-265941-eff4le0g	554	27	positive	positive	JJ
cord-265941-eff4le0g	554	28	bacterial	bacterial	JJ
cord-265941-eff4le0g	554	29	cell	cell	NN
cord-265941-eff4le0g	554	30	wall	wall	NN
cord-265941-eff4le0g	554	31	components	component	NNS
cord-265941-eff4le0g	554	32	by	by	IN
cord-265941-eff4le0g	554	33	the	the	DT
cord-265941-eff4le0g	554	34	innate	innate	JJ
cord-265941-eff4le0g	554	35	immune	immune	JJ
cord-265941-eff4le0g	554	36	system	system	NN
cord-265941-eff4le0g	554	37	occurs	occur	VBZ
cord-265941-eff4le0g	554	38	via	via	IN
cord-265941-eff4le0g	554	39	Toll	Toll	NNP
cord-265941-eff4le0g	554	40	-	-	HYPH
cord-265941-eff4le0g	554	41	like	like	JJ
cord-265941-eff4le0g	554	42	receptor	receptor	NN
cord-265941-eff4le0g	554	43	2	2	CD
cord-265941-eff4le0g	554	44	Cell	cell	NN
cord-265941-eff4le0g	554	45	wall	wall	NN
cord-265941-eff4le0g	554	46	-	-	HYPH
cord-265941-eff4le0g	554	47	mediated	mediate	VBN
cord-265941-eff4le0g	554	48	neuronal	neuronal	JJ
cord-265941-eff4le0g	554	49	damage	damage	NN
cord-265941-eff4le0g	554	50	in	in	IN
cord-265941-eff4le0g	554	51	early	early	JJ
cord-265941-eff4le0g	554	52	sepsis	sepsis	NN
cord-265941-eff4le0g	555	1	Interleukin-10	interleukin-10	PRP
cord-265941-eff4le0g	555	2	plays	play	VBZ
cord-265941-eff4le0g	555	3	a	a	DT
cord-265941-eff4le0g	555	4	key	key	JJ
cord-265941-eff4le0g	555	5	role	role	NN
cord-265941-eff4le0g	555	6	in	in	IN
cord-265941-eff4le0g	555	7	the	the	DT
cord-265941-eff4le0g	555	8	modulation	modulation	NN
cord-265941-eff4le0g	555	9	of	of	IN
cord-265941-eff4le0g	555	10	neutrophils	neutrophil	NNS
cord-265941-eff4le0g	555	11	recruitment	recruitment	NN
cord-265941-eff4le0g	555	12	and	and	CC
cord-265941-eff4le0g	555	13	lung	lung	NN
cord-265941-eff4le0g	555	14	inflammation	inflammation	NN
cord-265941-eff4le0g	555	15	during	during	IN
cord-265941-eff4le0g	555	16	infection	infection	NN
cord-265941-eff4le0g	555	17	by	by	IN
cord-265941-eff4le0g	555	18	Streptococcus	streptococcus	NN
cord-265941-eff4le0g	555	19	pneumoniae	pneumoniae	NN
cord-265941-eff4le0g	555	20	Nucleotide	nucleotide	NN
cord-265941-eff4le0g	555	21	-	-	HYPH
cord-265941-eff4le0g	555	22	binding	bind	VBG
cord-265941-eff4le0g	555	23	oligomerization	oligomerization	NN
cord-265941-eff4le0g	555	24	domain	domain	NN
cord-265941-eff4le0g	555	25	proteins	protein	NNS
cord-265941-eff4le0g	555	26	are	be	VBP
cord-265941-eff4le0g	555	27	innate	innate	JJ
cord-265941-eff4le0g	555	28	immune	immune	JJ
cord-265941-eff4le0g	555	29	receptors	receptor	NNS
cord-265941-eff4le0g	555	30	for	for	IN
cord-265941-eff4le0g	555	31	internalized	internalize	VBN
cord-265941-eff4le0g	555	32	Streptococcus	streptococcus	NN
cord-265941-eff4le0g	555	33	pneumoniae	pneumoniae	NN
cord-265941-eff4le0g	556	1	The	the	DT
cord-265941-eff4le0g	556	2	pattern	pattern	NN
cord-265941-eff4le0g	556	3	recognition	recognition	NN
cord-265941-eff4le0g	556	4	receptors	receptor	NNS
cord-265941-eff4le0g	557	1	Nod1	Nod1	NNP
cord-265941-eff4le0g	557	2	and	and	CC
cord-265941-eff4le0g	557	3	Nod2	Nod2	NNP
cord-265941-eff4le0g	557	4	account	account	VBP
cord-265941-eff4le0g	557	5	for	for	IN
cord-265941-eff4le0g	557	6	neutrophil	neutrophil	NN
cord-265941-eff4le0g	557	7	recruitment	recruitment	NN
cord-265941-eff4le0g	557	8	to	to	IN
cord-265941-eff4le0g	557	9	the	the	DT
cord-265941-eff4le0g	557	10	lungs	lung	NNS
cord-265941-eff4le0g	557	11	of	of	IN
cord-265941-eff4le0g	557	12	mice	mouse	NNS
cord-265941-eff4le0g	557	13	infected	infect	VBN
cord-265941-eff4le0g	557	14	with	with	IN
cord-265941-eff4le0g	557	15	Legionella	Legionella	NNP
cord-265941-eff4le0g	557	16	pneumophila	pneumophila	NN
cord-265941-eff4le0g	557	17	NOD1	NOD1	NNP
cord-265941-eff4le0g	557	18	and	and	CC
cord-265941-eff4le0g	557	19	NOD2	NOD2	NNP
cord-265941-eff4le0g	557	20	regulation	regulation	NN
cord-265941-eff4le0g	557	21	of	of	IN
cord-265941-eff4le0g	557	22	pulmonary	pulmonary	JJ
cord-265941-eff4le0g	557	23	innate	innate	JJ
cord-265941-eff4le0g	557	24	immunity	immunity	NN
cord-265941-eff4le0g	557	25	to	to	IN
cord-265941-eff4le0g	557	26	Legionella	Legionella	NNP
cord-265941-eff4le0g	557	27	pneumophila	pneumophila	NN
cord-265941-eff4le0g	557	28	Lyme	Lyme	NNP
cord-265941-eff4le0g	557	29	disease	disease	NN
cord-265941-eff4le0g	557	30	:	:	:
cord-265941-eff4le0g	558	1	review	review	VB
cord-265941-eff4le0g	558	2	Characterization	characterization	NN
cord-265941-eff4le0g	558	3	of	of	IN
cord-265941-eff4le0g	558	4	nucleotide	nucleotide	NN
cord-265941-eff4le0g	558	5	-	-	HYPH
cord-265941-eff4le0g	558	6	binding	bind	VBG
cord-265941-eff4le0g	558	7	oligomerization	oligomerization	NN
cord-265941-eff4le0g	558	8	domain	domain	NN
cord-265941-eff4le0g	558	9	(	(	-LRB-
cord-265941-eff4le0g	558	10	NOD	NOD	NNP
cord-265941-eff4le0g	558	11	)	)	-RRB-
cord-265941-eff4le0g	558	12	protein	protein	JJ
cord-265941-eff4le0g	558	13	expression	expression	NN
cord-265941-eff4le0g	558	14	in	in	IN
cord-265941-eff4le0g	558	15	primary	primary	JJ
cord-265941-eff4le0g	558	16	murine	murine	JJ
cord-265941-eff4le0g	558	17	microglia	microglia	JJ
cord-265941-eff4le0g	558	18	Functional	functional	JJ
cord-265941-eff4le0g	558	19	expression	expression	NN
cord-265941-eff4le0g	558	20	of	of	IN
cord-265941-eff4le0g	558	21	NOD2	NOD2	NNP
cord-265941-eff4le0g	558	22	,	,	,
cord-265941-eff4le0g	558	23	a	a	DT
cord-265941-eff4le0g	558	24	novel	novel	JJ
cord-265941-eff4le0g	558	25	pattern	pattern	NN
cord-265941-eff4le0g	558	26	recognition	recognition	NN
cord-265941-eff4le0g	558	27	receptor	receptor	NN
cord-265941-eff4le0g	558	28	for	for	IN
cord-265941-eff4le0g	558	29	bacterial	bacterial	JJ
cord-265941-eff4le0g	558	30	motifs	motif	NNS
cord-265941-eff4le0g	558	31	,	,	,
cord-265941-eff4le0g	558	32	in	in	IN
cord-265941-eff4le0g	558	33	primary	primary	JJ
cord-265941-eff4le0g	558	34	murine	murine	NN
cord-265941-eff4le0g	558	35	astrocytes	astrocyte	NNS
cord-265941-eff4le0g	558	36	Recognition	Recognition	NNP
cord-265941-eff4le0g	558	37	of	of	IN
cord-265941-eff4le0g	558	38	Borrelia	Borrelia	NNP
cord-265941-eff4le0g	558	39	burgdorferi	burgdorferi	NN
cord-265941-eff4le0g	558	40	by	by	IN
cord-265941-eff4le0g	558	41	NOD2	NOD2	NNP
cord-265941-eff4le0g	558	42	is	be	VBZ
cord-265941-eff4le0g	558	43	central	central	JJ
cord-265941-eff4le0g	558	44	for	for	IN
cord-265941-eff4le0g	558	45	the	the	DT
cord-265941-eff4le0g	558	46	induction	induction	NN
cord-265941-eff4le0g	558	47	of	of	IN
cord-265941-eff4le0g	558	48	an	an	DT
cord-265941-eff4le0g	558	49	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	558	50	reaction	reaction	NN
cord-265941-eff4le0g	558	51	Inflammatory	inflammatory	JJ
cord-265941-eff4le0g	558	52	signaling	signaling	NN
cord-265941-eff4le0g	558	53	by	by	IN
cord-265941-eff4le0g	558	54	NOD	nod	JJ
cord-265941-eff4le0g	558	55	-	-	HYPH
cord-265941-eff4le0g	558	56	RIPK2	ripk2	NN
cord-265941-eff4le0g	558	57	is	be	VBZ
cord-265941-eff4le0g	558	58	inhibited	inhibit	VBN
cord-265941-eff4le0g	558	59	by	by	IN
cord-265941-eff4le0g	558	60	clinically	clinically	RB
cord-265941-eff4le0g	558	61	relevant	relevant	JJ
cord-265941-eff4le0g	558	62	type	type	NN
cord-265941-eff4le0g	558	63	II	II	NNP
cord-265941-eff4le0g	558	64	kinase	kinase	NN
cord-265941-eff4le0g	558	65	inhibitors	inhibitor	NNS
cord-265941-eff4le0g	558	66	Activation	Activation	NNP
cord-265941-eff4le0g	558	67	of	of	IN
cord-265941-eff4le0g	558	68	NOD2-mediated	NOD2-mediated	NNP
cord-265941-eff4le0g	558	69	intestinal	intestinal	JJ
cord-265941-eff4le0g	558	70	pathway	pathway	NN
cord-265941-eff4le0g	558	71	in	in	IN
cord-265941-eff4le0g	558	72	a	a	DT
cord-265941-eff4le0g	558	73	pediatric	pediatric	JJ
cord-265941-eff4le0g	558	74	population	population	NN
cord-265941-eff4le0g	558	75	with	with	IN
cord-265941-eff4le0g	558	76	Crohn	Crohn	NNP
cord-265941-eff4le0g	558	77	's	's	POS
cord-265941-eff4le0g	558	78	disease	disease	NN
cord-265941-eff4le0g	558	79	Digesting	digest	VBG
cord-265941-eff4le0g	558	80	the	the	DT
cord-265941-eff4le0g	558	81	genetics	genetic	NNS
cord-265941-eff4le0g	558	82	of	of	IN
cord-265941-eff4le0g	558	83	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	558	84	bowel	bowel	NN
cord-265941-eff4le0g	558	85	disease	disease	NN
cord-265941-eff4le0g	558	86	:	:	:
cord-265941-eff4le0g	558	87	insights	insight	NNS
cord-265941-eff4le0g	558	88	from	from	IN
cord-265941-eff4le0g	558	89	studies	study	NNS
cord-265941-eff4le0g	558	90	of	of	IN
cord-265941-eff4le0g	558	91	autophagy	autophagy	NN
cord-265941-eff4le0g	558	92	risk	risk	NN
cord-265941-eff4le0g	558	93	genes	gene	NNS
cord-265941-eff4le0g	558	94	Autophagy	Autophagy	NNPS
cord-265941-eff4le0g	558	95	in	in	IN
cord-265941-eff4le0g	558	96	intracellular	intracellular	JJ
cord-265941-eff4le0g	558	97	bacterial	bacterial	JJ
cord-265941-eff4le0g	558	98	infection	infection	NN
cord-265941-eff4le0g	558	99	Autophagy	Autophagy	NNP
cord-265941-eff4le0g	558	100	,	,	,
cord-265941-eff4le0g	558	101	immunity	immunity	NN
cord-265941-eff4le0g	558	102	,	,	,
cord-265941-eff4le0g	558	103	and	and	CC
cord-265941-eff4le0g	558	104	microbial	microbial	JJ
cord-265941-eff4le0g	558	105	adaptations	adaptation	NNS
cord-265941-eff4le0g	559	1	Autophagy	Autophagy	NNS
cord-265941-eff4le0g	559	2	in	in	IN
cord-265941-eff4le0g	559	3	immunity	immunity	NN
cord-265941-eff4le0g	559	4	against	against	IN
cord-265941-eff4le0g	559	5	intracellular	intracellular	JJ
cord-265941-eff4le0g	559	6	bacteria	bacteria	NNS
cord-265941-eff4le0g	559	7	Morbidity	morbidity	NN
cord-265941-eff4le0g	559	8	and	and	CC
cord-265941-eff4le0g	559	9	mortality	mortality	NN
cord-265941-eff4le0g	559	10	due	due	IN
cord-265941-eff4le0g	559	11	to	to	IN
cord-265941-eff4le0g	559	12	shigella	shigella	NNP
cord-265941-eff4le0g	559	13	Disease	Disease	NNP
cord-265941-eff4le0g	559	14	Study	Study	NNP
cord-265941-eff4le0g	560	1	Extensively	extensively	RB
cord-265941-eff4le0g	560	2	drug	drug	NN
cord-265941-eff4le0g	560	3	-	-	HYPH
cord-265941-eff4le0g	560	4	resistant	resistant	JJ
cord-265941-eff4le0g	560	5	shigellosis	shigellosis	NN
cord-265941-eff4le0g	560	6	in	in	IN
cord-265941-eff4le0g	560	7	Australia	Australia	NNP
cord-265941-eff4le0g	560	8	among	among	IN
cord-265941-eff4le0g	560	9	men	man	NNS
cord-265941-eff4le0g	560	10	who	who	WP
cord-265941-eff4le0g	560	11	have	have	VBP
cord-265941-eff4le0g	560	12	sex	sex	NN
cord-265941-eff4le0g	560	13	with	with	IN
cord-265941-eff4le0g	560	14	men	man	NNS
cord-265941-eff4le0g	560	15	CARD4	CARD4	NNP
cord-265941-eff4le0g	560	16	/	/	SYM
cord-265941-eff4le0g	560	17	Nod1	Nod1	NNP
cord-265941-eff4le0g	560	18	mediates	mediate	VBZ
cord-265941-eff4le0g	560	19	NF	NF	NNP
cord-265941-eff4le0g	560	20	-	-	HYPH
cord-265941-eff4le0g	560	21	kappaB	kappaB	NNP
cord-265941-eff4le0g	560	22	and	and	CC
cord-265941-eff4le0g	560	23	JNK	JNK	NNP
cord-265941-eff4le0g	560	24	activation	activation	NN
cord-265941-eff4le0g	560	25	by	by	IN
cord-265941-eff4le0g	560	26	invasive	invasive	JJ
cord-265941-eff4le0g	560	27	Shigella	Shigella	NNP
cord-265941-eff4le0g	560	28	flexneri	flexneri	NNP
cord-265941-eff4le0g	560	29	Association	Association	NNP
cord-265941-eff4le0g	560	30	between	between	IN
cord-265941-eff4le0g	560	31	infection	infection	NN
cord-265941-eff4le0g	560	32	with	with	IN
cord-265941-eff4le0g	560	33	Helicobacter	Helicobacter	NNP
cord-265941-eff4le0g	560	34	pylori	pylori	NN
cord-265941-eff4le0g	560	35	and	and	CC
cord-265941-eff4le0g	560	36	risk	risk	NN
cord-265941-eff4le0g	560	37	of	of	IN
cord-265941-eff4le0g	560	38	gastric	gastric	JJ
cord-265941-eff4le0g	560	39	cancer	cancer	NN
cord-265941-eff4le0g	560	40	:	:	:
cord-265941-eff4le0g	560	41	evidence	evidence	NN
cord-265941-eff4le0g	560	42	from	from	IN
cord-265941-eff4le0g	560	43	a	a	DT
cord-265941-eff4le0g	560	44	prospective	prospective	JJ
cord-265941-eff4le0g	560	45	investigation	investigation	NN
cord-265941-eff4le0g	560	46	Helicobacter	helicobacter	NN
cord-265941-eff4le0g	560	47	pylori	pylori	NN
cord-265941-eff4le0g	560	48	infection	infection	NN
cord-265941-eff4le0g	560	49	and	and	CC
cord-265941-eff4le0g	560	50	the	the	DT
cord-265941-eff4le0g	560	51	risk	risk	NN
cord-265941-eff4le0g	560	52	of	of	IN
cord-265941-eff4le0g	560	53	gastric	gastric	JJ
cord-265941-eff4le0g	560	54	carcinoma	carcinoma	NN
cord-265941-eff4le0g	560	55	Helicobacter	helicobacter	NN
cord-265941-eff4le0g	560	56	pylori	pylori	NN
cord-265941-eff4le0g	560	57	infection	infection	NN
cord-265941-eff4le0g	560	58	and	and	CC
cord-265941-eff4le0g	560	59	the	the	DT
cord-265941-eff4le0g	560	60	development	development	NN
cord-265941-eff4le0g	560	61	of	of	IN
cord-265941-eff4le0g	560	62	gastric	gastric	JJ
cord-265941-eff4le0g	560	63	cancer	cancer	NN
cord-265941-eff4le0g	560	64	Association	Association	NNP
cord-265941-eff4le0g	560	65	between	between	IN
cord-265941-eff4le0g	560	66	receptor	receptor	NN
cord-265941-eff4le0g	560	67	interacting	interact	VBG
cord-265941-eff4le0g	560	68	serine	serine	NN
cord-265941-eff4le0g	560	69	/	/	SYM
cord-265941-eff4le0g	560	70	threonine	threonine	NN
cord-265941-eff4le0g	560	71	kinase	kinase	VBN
cord-265941-eff4le0g	560	72	2	2	CD
cord-265941-eff4le0g	560	73	polymorphisms	polymorphism	NNS
cord-265941-eff4le0g	560	74	and	and	CC
cord-265941-eff4le0g	560	75	gastric	gastric	JJ
cord-265941-eff4le0g	560	76	cancer	cancer	NN
cord-265941-eff4le0g	560	77	susceptibility	susceptibility	NN
cord-265941-eff4le0g	561	1	Nod1	Nod1	NNP
cord-265941-eff4le0g	561	2	responds	respond	VBZ
cord-265941-eff4le0g	561	3	to	to	IN
cord-265941-eff4le0g	561	4	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	561	5	delivered	deliver	VBN
cord-265941-eff4le0g	561	6	by	by	IN
cord-265941-eff4le0g	561	7	the	the	DT
cord-265941-eff4le0g	561	8	Helicobacter	Helicobacter	NNP
cord-265941-eff4le0g	561	9	pylori	pylori	NN
cord-265941-eff4le0g	562	1	cag	cag	NNP
cord-265941-eff4le0g	562	2	pathogenicity	pathogenicity	NNP
cord-265941-eff4le0g	562	3	island	island	NNP
cord-265941-eff4le0g	562	4	Amino	Amino	NNP
cord-265941-eff4le0g	562	5	acid	acid	NN
cord-265941-eff4le0g	562	6	starvation	starvation	NN
cord-265941-eff4le0g	562	7	induced	induce	VBN
cord-265941-eff4le0g	562	8	by	by	IN
cord-265941-eff4le0g	562	9	invasive	invasive	JJ
cord-265941-eff4le0g	562	10	bacterial	bacterial	JJ
cord-265941-eff4le0g	562	11	pathogens	pathogen	NNS
cord-265941-eff4le0g	562	12	triggers	trigger	VBZ
cord-265941-eff4le0g	562	13	an	an	DT
cord-265941-eff4le0g	562	14	innate	innate	JJ
cord-265941-eff4le0g	562	15	host	host	NN
cord-265941-eff4le0g	562	16	defense	defense	NN
cord-265941-eff4le0g	562	17	program	program	NN
cord-265941-eff4le0g	562	18	TLR2	TLR2	NNP
cord-265941-eff4le0g	562	19	and	and	CC
cord-265941-eff4le0g	562	20	RIP2	RIP2	NNP
cord-265941-eff4le0g	562	21	pathways	pathway	NNS
cord-265941-eff4le0g	562	22	mediate	mediate	VBP
cord-265941-eff4le0g	562	23	autophagy	autophagy	NN
cord-265941-eff4le0g	562	24	of	of	IN
cord-265941-eff4le0g	562	25	Listeria	Listeria	NNP
cord-265941-eff4le0g	562	26	monocytogenes	monocytogene	NNS
cord-265941-eff4le0g	562	27	via	via	IN
cord-265941-eff4le0g	562	28	extracellular	extracellular	JJ
cord-265941-eff4le0g	562	29	signalregulated	signalregulated	JJ
cord-265941-eff4le0g	562	30	kinase	kinase	NN
cord-265941-eff4le0g	562	31	(	(	-LRB-
cord-265941-eff4le0g	562	32	ERK	ERK	NNP
cord-265941-eff4le0g	562	33	)	)	-RRB-
cord-265941-eff4le0g	562	34	activation	activation	NN
cord-265941-eff4le0g	563	1	A	a	DT
cord-265941-eff4le0g	563	2	dual	dual	JJ
cord-265941-eff4le0g	563	3	role	role	NN
cord-265941-eff4le0g	563	4	for	for	IN
cord-265941-eff4le0g	563	5	receptorinteracting	receptorinteracte	VBG
cord-265941-eff4le0g	563	6	protein	protein	NN
cord-265941-eff4le0g	563	7	kinase	kinase	NNP
cord-265941-eff4le0g	563	8	2	2	CD
cord-265941-eff4le0g	563	9	(	(	-LRB-
cord-265941-eff4le0g	563	10	RIP2	RIP2	NNP
cord-265941-eff4le0g	563	11	)	)	-RRB-
cord-265941-eff4le0g	564	1	kinase	kinase	NN
cord-265941-eff4le0g	564	2	activity	activity	NN
cord-265941-eff4le0g	564	3	in	in	IN
cord-265941-eff4le0g	564	4	nucleotide	nucleotide	RB
cord-265941-eff4le0g	564	5	-	-	HYPH
cord-265941-eff4le0g	564	6	binding	bind	VBG
cord-265941-eff4le0g	564	7	oligomerization	oligomerization	NN
cord-265941-eff4le0g	564	8	domain	domain	NN
cord-265941-eff4le0g	564	9	2	2	CD
cord-265941-eff4le0g	564	10	(	(	-LRB-
cord-265941-eff4le0g	564	11	NOD2)-dependent	nod2)-dependent	CD
cord-265941-eff4le0g	564	12	autophagy	autophagy	NN
cord-265941-eff4le0g	564	13	The	the	DT
cord-265941-eff4le0g	564	14	Salmonella	Salmonella	NNP
cord-265941-eff4le0g	564	15	type	type	NN
cord-265941-eff4le0g	564	16	III	iii	CD
cord-265941-eff4le0g	564	17	effector	effector	NN
cord-265941-eff4le0g	564	18	SspH2	SspH2	NNP
cord-265941-eff4le0g	564	19	specifically	specifically	RB
cord-265941-eff4le0g	564	20	exploits	exploit	VBZ
cord-265941-eff4le0g	564	21	the	the	DT
cord-265941-eff4le0g	564	22	NLR	NLR	NNP
cord-265941-eff4le0g	564	23	Co	co	NN
cord-265941-eff4le0g	564	24	-	-	NN
cord-265941-eff4le0g	564	25	chaperone	chaperone	JJ
cord-265941-eff4le0g	564	26	activity	activity	NN
cord-265941-eff4le0g	564	27	of	of	IN
cord-265941-eff4le0g	564	28	SGT1	SGT1	NNP
cord-265941-eff4le0g	564	29	to	to	TO
cord-265941-eff4le0g	564	30	subvert	subvert	VB
cord-265941-eff4le0g	564	31	immunity	immunity	NN
cord-265941-eff4le0g	564	32	GEF	GEF	NNP
cord-265941-eff4le0g	564	33	-	-	HYPH
cord-265941-eff4le0g	564	34	H1	h1	NN
cord-265941-eff4le0g	564	35	mediated	mediate	VBN
cord-265941-eff4le0g	564	36	control	control	NN
cord-265941-eff4le0g	564	37	of	of	IN
cord-265941-eff4le0g	564	38	NOD1	NOD1	NNP
cord-265941-eff4le0g	564	39	dependent	dependent	JJ
cord-265941-eff4le0g	564	40	NF	NF	NNP
cord-265941-eff4le0g	564	41	-	-	HYPH
cord-265941-eff4le0g	564	42	kappaB	kappaB	NNP
cord-265941-eff4le0g	564	43	activation	activation	NN
cord-265941-eff4le0g	564	44	by	by	IN
cord-265941-eff4le0g	564	45	Shigella	Shigella	NNP
cord-265941-eff4le0g	564	46	effectors	effector	NNS
cord-265941-eff4le0g	564	47	Manipulation	manipulation	NN
cord-265941-eff4le0g	564	48	of	of	IN
cord-265941-eff4le0g	564	49	small	small	JJ
cord-265941-eff4le0g	564	50	Rho	rho	NN
cord-265941-eff4le0g	564	51	GTPases	gtpase	NNS
cord-265941-eff4le0g	565	1	is	be	VBZ
cord-265941-eff4le0g	565	2	a	a	DT
cord-265941-eff4le0g	565	3	pathogeninduced	pathogeninduced	JJ
cord-265941-eff4le0g	565	4	process	process	NN
cord-265941-eff4le0g	565	5	detected	detect	VBN
cord-265941-eff4le0g	565	6	by	by	IN
cord-265941-eff4le0g	565	7	NOD1	NOD1	NNP
cord-265941-eff4le0g	566	1	A	a	DT
cord-265941-eff4le0g	566	2	Salmonella	Salmonella	NNP
cord-265941-eff4le0g	566	3	virulence	virulence	NN
cord-265941-eff4le0g	566	4	factor	factor	NN
cord-265941-eff4le0g	566	5	activates	activate	VBZ
cord-265941-eff4le0g	566	6	the	the	DT
cord-265941-eff4le0g	566	7	NOD1	NOD1	NNP
cord-265941-eff4le0g	566	8	/	/	SYM
cord-265941-eff4le0g	566	9	NOD2	NOD2	NNP
cord-265941-eff4le0g	566	10	signaling	signal	VBG
cord-265941-eff4le0g	566	11	pathway	pathway	NN
cord-265941-eff4le0g	567	1	The	the	DT
cord-265941-eff4le0g	567	2	small	small	JJ
cord-265941-eff4le0g	567	3	GTPase	GTPase	NNP
cord-265941-eff4le0g	567	4	rho	rho	NN
cord-265941-eff4le0g	567	5	:	:	:
cord-265941-eff4le0g	567	6	cellular	cellular	JJ
cord-265941-eff4le0g	567	7	functions	function	NNS
cord-265941-eff4le0g	567	8	and	and	CC
cord-265941-eff4le0g	567	9	signal	signal	NN
cord-265941-eff4le0g	567	10	transduction	transduction	NN
cord-265941-eff4le0g	567	11	Assembly	assembly	NN
cord-265941-eff4le0g	567	12	,	,	,
cord-265941-eff4le0g	567	13	structure	structure	NN
cord-265941-eff4le0g	567	14	,	,	,
cord-265941-eff4le0g	567	15	function	function	NN
cord-265941-eff4le0g	567	16	and	and	CC
cord-265941-eff4le0g	567	17	regulation	regulation	NN
cord-265941-eff4le0g	567	18	of	of	IN
cord-265941-eff4le0g	567	19	type	type	NN
cord-265941-eff4le0g	567	20	III	iii	CD
cord-265941-eff4le0g	567	21	secretion	secretion	NN
cord-265941-eff4le0g	567	22	systems	system	NNS
cord-265941-eff4le0g	567	23	Pathogen	pathogen	NN
cord-265941-eff4le0g	567	24	-	-	HYPH
cord-265941-eff4le0g	567	25	derived	derive	VBN
cord-265941-eff4le0g	567	26	effectors	effector	NNS
cord-265941-eff4le0g	567	27	trigger	trigger	VBP
cord-265941-eff4le0g	567	28	protective	protective	JJ
cord-265941-eff4le0g	567	29	immunity	immunity	NN
cord-265941-eff4le0g	567	30	via	via	IN
cord-265941-eff4le0g	567	31	activation	activation	NN
cord-265941-eff4le0g	567	32	of	of	IN
cord-265941-eff4le0g	567	33	the	the	DT
cord-265941-eff4le0g	567	34	Rac2	Rac2	NNP
cord-265941-eff4le0g	567	35	enzyme	enzyme	NN
cord-265941-eff4le0g	567	36	and	and	CC
cord-265941-eff4le0g	567	37	the	the	DT
cord-265941-eff4le0g	567	38	IMD	IMD	NNP
cord-265941-eff4le0g	567	39	or	or	CC
cord-265941-eff4le0g	567	40	rip	rip	VBP
cord-265941-eff4le0g	567	41	kinase	kinase	NN
cord-265941-eff4le0g	567	42	signaling	signal	VBG
cord-265941-eff4le0g	567	43	pathway	pathway	NN
cord-265941-eff4le0g	567	44	NOD1	NOD1	NNP
cord-265941-eff4le0g	567	45	and	and	CC
cord-265941-eff4le0g	567	46	NOD2	NOD2	NNPS
cord-265941-eff4le0g	567	47	:	:	:
cord-265941-eff4le0g	567	48	beyond	beyond	IN
cord-265941-eff4le0g	567	49	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	567	50	sensing	sense	VBG
cord-265941-eff4le0g	567	51	NOD1	NOD1	NNP
cord-265941-eff4le0g	567	52	and	and	CC
cord-265941-eff4le0g	567	53	NOD2	NOD2	NNPS
cord-265941-eff4le0g	568	1	signalling	signal	VBG
cord-265941-eff4le0g	568	2	links	link	NNS
cord-265941-eff4le0g	568	3	ER	ER	NNP
cord-265941-eff4le0g	568	4	stress	stress	NN
cord-265941-eff4le0g	568	5	with	with	IN
cord-265941-eff4le0g	568	6	inflammation	inflammation	NN
cord-265941-eff4le0g	568	7	Stimulation	stimulation	NN
cord-265941-eff4le0g	568	8	of	of	IN
cord-265941-eff4le0g	568	9	the	the	DT
cord-265941-eff4le0g	568	10	cytosolic	cytosolic	JJ
cord-265941-eff4le0g	568	11	receptor	receptor	NN
cord-265941-eff4le0g	568	12	for	for	IN
cord-265941-eff4le0g	568	13	peptidoglycan	peptidoglycan	NN
cord-265941-eff4le0g	568	14	,	,	,
cord-265941-eff4le0g	568	15	Nod1	Nod1	NNP
cord-265941-eff4le0g	568	16	,	,	,
cord-265941-eff4le0g	568	17	by	by	IN
cord-265941-eff4le0g	568	18	infection	infection	NN
cord-265941-eff4le0g	568	19	with	with	IN
cord-265941-eff4le0g	568	20	Chlamydia	Chlamydia	NNP
cord-265941-eff4le0g	568	21	trachomatis	trachomatis	NN
cord-265941-eff4le0g	568	22	or	or	CC
cord-265941-eff4le0g	568	23	Chlamydia	Chlamydia	NNP
cord-265941-eff4le0g	568	24	muridarum	muridarum	NNP
cord-265941-eff4le0g	569	1	Influenza	influenza	NN
cord-265941-eff4le0g	569	2	induces	induce	VBZ
cord-265941-eff4le0g	569	3	endoplasmic	endoplasmic	NN
cord-265941-eff4le0g	569	4	reticulum	reticulum	NN
cord-265941-eff4le0g	569	5	stress	stress	NN
cord-265941-eff4le0g	569	6	,	,	.
cord-265941-eff4le0g	570	1	caspase-12-dependent	caspase-12-dependent	NN
cord-265941-eff4le0g	570	2	apoptosis	apoptosis	NN
cord-265941-eff4le0g	570	3	,	,	,
cord-265941-eff4le0g	570	4	and	and	CC
cord-265941-eff4le0g	570	5	c	c	LS
cord-265941-eff4le0g	570	6	-	-	:
cord-265941-eff4le0g	570	7	Jun	Jun	NNP
cord-265941-eff4le0g	570	8	N	N	NNP
cord-265941-eff4le0g	570	9	-	-	HYPH
cord-265941-eff4le0g	570	10	terminal	terminal	JJ
cord-265941-eff4le0g	570	11	kinase	kinase	NN
cord-265941-eff4le0g	570	12	-	-	HYPH
cord-265941-eff4le0g	570	13	mediated	mediate	VBN
cord-265941-eff4le0g	570	14	transforming	transform	VBG
cord-265941-eff4le0g	570	15	growth	growth	NN
cord-265941-eff4le0g	570	16	factor	factor	NN
cord-265941-eff4le0g	570	17	-	-	HYPH
cord-265941-eff4le0g	570	18	β	β	NN
cord-265941-eff4le0g	570	19	release	release	NN
cord-265941-eff4le0g	570	20	in	in	IN
cord-265941-eff4le0g	570	21	lung	lung	NN
cord-265941-eff4le0g	570	22	epithelial	epithelial	NN
cord-265941-eff4le0g	570	23	cells	cell	NNS
cord-265941-eff4le0g	571	1	Human	human	JJ
cord-265941-eff4le0g	571	2	cytomegalovirus	cytomegalovirus	NN
cord-265941-eff4le0g	571	3	induces	induce	VBZ
cord-265941-eff4le0g	571	4	apoptosis	apoptosis	NN
cord-265941-eff4le0g	571	5	in	in	IN
cord-265941-eff4le0g	571	6	neural	neural	JJ
cord-265941-eff4le0g	571	7	stem	stem	NN
cord-265941-eff4le0g	571	8	/	/	SYM
cord-265941-eff4le0g	571	9	progenitor	progenitor	NN
cord-265941-eff4le0g	571	10	cells	cell	NNS
cord-265941-eff4le0g	571	11	derived	derive	VBN
cord-265941-eff4le0g	571	12	from	from	IN
cord-265941-eff4le0g	571	13	induced	induce	VBN
cord-265941-eff4le0g	571	14	pluripotent	pluripotent	JJ
cord-265941-eff4le0g	571	15	stem	stem	NN
cord-265941-eff4le0g	571	16	cells	cell	NNS
cord-265941-eff4le0g	571	17	by	by	IN
cord-265941-eff4le0g	571	18	generating	generate	VBG
cord-265941-eff4le0g	571	19	mitochondrial	mitochondrial	JJ
cord-265941-eff4le0g	571	20	dysfunction	dysfunction	NN
cord-265941-eff4le0g	571	21	and	and	CC
cord-265941-eff4le0g	571	22	endoplasmic	endoplasmic	NN
cord-265941-eff4le0g	571	23	reticulum	reticulum	NN
cord-265941-eff4le0g	572	1	stress	stress	NN
cord-265941-eff4le0g	573	1	Receptor	receptor	NN
cord-265941-eff4le0g	573	2	-	-	HYPH
cord-265941-eff4le0g	573	3	interacting	interact	VBG
cord-265941-eff4le0g	573	4	protein	protein	NN
cord-265941-eff4le0g	574	1	Kinase-2	Kinase-2	NNP
cord-265941-eff4le0g	574	2	inhibition	inhibition	NN
cord-265941-eff4le0g	574	3	by	by	IN
cord-265941-eff4le0g	574	4	CYLD	CYLD	NNP
cord-265941-eff4le0g	574	5	impairs	impair	VBZ
cord-265941-eff4le0g	574	6	antibacterial	antibacterial	JJ
cord-265941-eff4le0g	574	7	immune	immune	JJ
cord-265941-eff4le0g	574	8	responses	response	NNS
cord-265941-eff4le0g	574	9	in	in	IN
cord-265941-eff4le0g	574	10	macrophages	macrophage	NNS
cord-265941-eff4le0g	575	1	XIAP	XIAP	NNP
cord-265941-eff4le0g	575	2	controls	control	VBZ
cord-265941-eff4le0g	575	3	RIPK2	ripk2	NN
cord-265941-eff4le0g	575	4	signaling	signal	VBG
cord-265941-eff4le0g	575	5	by	by	IN
cord-265941-eff4le0g	575	6	preventing	prevent	VBG
cord-265941-eff4le0g	575	7	its	-PRON-	PRP$
cord-265941-eff4le0g	575	8	deposition	deposition	NN
cord-265941-eff4le0g	575	9	in	in	IN
cord-265941-eff4le0g	575	10	speck	speck	NN
cord-265941-eff4le0g	575	11	-	-	HYPH
cord-265941-eff4le0g	575	12	like	like	JJ
cord-265941-eff4le0g	575	13	structures	structure	NNS
cord-265941-eff4le0g	575	14	Structural	structural	JJ
cord-265941-eff4le0g	575	15	basis	basis	NN
cord-265941-eff4le0g	575	16	of	of	IN
cord-265941-eff4le0g	575	17	RIP2	RIP2	NNP
cord-265941-eff4le0g	575	18	activation	activation	NN
cord-265941-eff4le0g	575	19	and	and	CC
cord-265941-eff4le0g	576	1	signaling	signal	VBG
cord-265941-eff4le0g	576	2	Viral	viral	JJ
cord-265941-eff4le0g	576	3	infection	infection	NN
cord-265941-eff4le0g	576	4	augments	augment	VBZ
cord-265941-eff4le0g	576	5	Nod1/2	nod1/2	NN
cord-265941-eff4le0g	576	6	signaling	signal	VBG
cord-265941-eff4le0g	576	7	to	to	TO
cord-265941-eff4le0g	576	8	potentiate	potentiate	VB
cord-265941-eff4le0g	576	9	lethality	lethality	NN
cord-265941-eff4le0g	576	10	associated	associate	VBN
cord-265941-eff4le0g	576	11	with	with	IN
cord-265941-eff4le0g	576	12	secondary	secondary	JJ
cord-265941-eff4le0g	576	13	bacterial	bacterial	JJ
cord-265941-eff4le0g	576	14	infections	infection	NNS
cord-265941-eff4le0g	576	15	Molecular	molecular	JJ
cord-265941-eff4le0g	576	16	cloning	clone	VBG
cord-265941-eff4le0g	576	17	and	and	CC
cord-265941-eff4le0g	576	18	functional	functional	JJ
cord-265941-eff4le0g	576	19	analysis	analysis	NN
cord-265941-eff4le0g	576	20	of	of	IN
cord-265941-eff4le0g	576	21	nucleotide	nucleotide	NN
cord-265941-eff4le0g	576	22	-	-	HYPH
cord-265941-eff4le0g	576	23	binding	bind	VBG
cord-265941-eff4le0g	576	24	oligomerization	oligomerization	NN
cord-265941-eff4le0g	576	25	domain	domain	NN
cord-265941-eff4le0g	576	26	1	1	CD
cord-265941-eff4le0g	576	27	(	(	-LRB-
cord-265941-eff4le0g	576	28	NOD1	NOD1	NNP
cord-265941-eff4le0g	576	29	)	)	-RRB-
cord-265941-eff4le0g	576	30	in	in	IN
cord-265941-eff4le0g	576	31	olive	olive	NN
cord-265941-eff4le0g	576	32	flounder	flounder	NN
cord-265941-eff4le0g	576	33	,	,	,
cord-265941-eff4le0g	576	34	Paralichthys	Paralichthys	NNP
cord-265941-eff4le0g	576	35	olivaceus	olivaceus	NN
cord-265941-eff4le0g	576	36	Activation	Activation	NNP
cord-265941-eff4le0g	576	37	of	of	IN
cord-265941-eff4le0g	576	38	innate	innate	JJ
cord-265941-eff4le0g	576	39	immune	immune	JJ
cord-265941-eff4le0g	576	40	antiviral	antiviral	JJ
cord-265941-eff4le0g	576	41	responses	response	NNS
cord-265941-eff4le0g	576	42	by	by	IN
cord-265941-eff4le0g	576	43	Nod2	Nod2	NNP
cord-265941-eff4le0g	576	44	A	A	NNP
cord-265941-eff4le0g	576	45	physical	physical	JJ
cord-265941-eff4le0g	576	46	and	and	CC
cord-265941-eff4le0g	576	47	regulatory	regulatory	JJ
cord-265941-eff4le0g	576	48	map	map	NN
cord-265941-eff4le0g	576	49	of	of	IN
cord-265941-eff4le0g	576	50	host	host	NN
cord-265941-eff4le0g	576	51	-	-	HYPH
cord-265941-eff4le0g	576	52	influenza	influenza	NN
cord-265941-eff4le0g	576	53	interactions	interaction	NNS
cord-265941-eff4le0g	576	54	reveals	reveal	VBZ
cord-265941-eff4le0g	576	55	pathways	pathway	NNS
cord-265941-eff4le0g	576	56	in	in	IN
cord-265941-eff4le0g	576	57	H1N1	H1N1	NNP
cord-265941-eff4le0g	576	58	infection	infection	NN
cord-265941-eff4le0g	576	59	Receptor	Receptor	NNP
cord-265941-eff4le0g	576	60	interacting	interact	VBG
cord-265941-eff4le0g	576	61	protein	protein	NN
cord-265941-eff4le0g	576	62	kinase	kinase	VBD
cord-265941-eff4le0g	576	63	2-mediated	2-mediated	CD
cord-265941-eff4le0g	576	64	mitophagy	mitophagy	NNP
cord-265941-eff4le0g	576	65	regulates	regulate	VBZ
cord-265941-eff4le0g	576	66	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	576	67	activation	activation	NN
cord-265941-eff4le0g	576	68	during	during	IN
cord-265941-eff4le0g	576	69	virus	virus	NN
cord-265941-eff4le0g	576	70	infection	infection	NN
cord-265941-eff4le0g	577	1	A	a	DT
cord-265941-eff4le0g	577	2	clinical	clinical	JJ
cord-265941-eff4le0g	577	3	review	review	NN
cord-265941-eff4le0g	577	4	of	of	IN
cord-265941-eff4le0g	577	5	viral	viral	JJ
cord-265941-eff4le0g	577	6	hepatitis	hepatitis	NN
cord-265941-eff4le0g	577	7	Simonin	Simonin	NNP
cord-265941-eff4le0g	578	1	,	,	,
cord-265941-eff4le0g	578	2	NOD1	NOD1	NNP
cord-265941-eff4le0g	578	3	participates	participate	VBZ
cord-265941-eff4le0g	578	4	in	in	IN
cord-265941-eff4le0g	578	5	the	the	DT
cord-265941-eff4le0g	578	6	innate	innate	JJ
cord-265941-eff4le0g	578	7	immune	immune	JJ
cord-265941-eff4le0g	578	8	response	response	NN
cord-265941-eff4le0g	578	9	triggered	trigger	VBN
cord-265941-eff4le0g	578	10	by	by	IN
cord-265941-eff4le0g	578	11	hepatitis	hepatitis	NN
cord-265941-eff4le0g	578	12	C	C	NNP
cord-265941-eff4le0g	578	13	virus	virus	NN
cord-265941-eff4le0g	578	14	polymerase	polymerase	NN
cord-265941-eff4le0g	578	15	Hepatitis	Hepatitis	NNP
cord-265941-eff4le0g	578	16	B	B	NNP
cord-265941-eff4le0g	578	17	virus	virus	NN
cord-265941-eff4le0g	578	18	e	e	NN
cord-265941-eff4le0g	578	19	antigen	antigen	NNP
cord-265941-eff4le0g	578	20	physically	physically	RB
cord-265941-eff4le0g	578	21	associates	associate	VBZ
cord-265941-eff4le0g	578	22	with	with	IN
cord-265941-eff4le0g	578	23	receptor	receptor	NN
cord-265941-eff4le0g	578	24	-	-	HYPH
cord-265941-eff4le0g	578	25	interacting	interact	VBG
cord-265941-eff4le0g	578	26	Serine	Serine	NNP
cord-265941-eff4le0g	578	27	/	/	SYM
cord-265941-eff4le0g	578	28	Threonine	Threonine	NNP
cord-265941-eff4le0g	578	29	protein	protein	NN
cord-265941-eff4le0g	578	30	kinase	kinase	VBD
cord-265941-eff4le0g	578	31	2	2	CD
cord-265941-eff4le0g	578	32	and	and	CC
cord-265941-eff4le0g	578	33	regulates	regulate	VBZ
cord-265941-eff4le0g	578	34	IL-6	IL-6	NNP
cord-265941-eff4le0g	578	35	gene	gene	NN
cord-265941-eff4le0g	578	36	expression	expression	NN
cord-265941-eff4le0g	578	37	Pathogen	pathogen	NN
cord-265941-eff4le0g	578	38	-	-	HYPH
cord-265941-eff4le0g	578	39	mediated	mediate	VBN
cord-265941-eff4le0g	578	40	proteolysis	proteolysis	NN
cord-265941-eff4le0g	578	41	of	of	IN
cord-265941-eff4le0g	578	42	the	the	DT
cord-265941-eff4le0g	578	43	cell	cell	NN
cord-265941-eff4le0g	578	44	death	death	NN
cord-265941-eff4le0g	578	45	regulator	regulator	NN
cord-265941-eff4le0g	578	46	RIPK1	RIPK1	NNP
cord-265941-eff4le0g	578	47	and	and	CC
cord-265941-eff4le0g	579	1	the	the	DT
cord-265941-eff4le0g	579	2	host	host	NN
cord-265941-eff4le0g	579	3	defense	defense	NN
cord-265941-eff4le0g	579	4	modulator	modulator	NN
cord-265941-eff4le0g	579	5	RIPK2	ripk2	XX
cord-265941-eff4le0g	579	6	in	in	IN
cord-265941-eff4le0g	579	7	human	human	JJ
cord-265941-eff4le0g	579	8	aortic	aortic	JJ
cord-265941-eff4le0g	579	9	endothelial	endothelial	JJ
cord-265941-eff4le0g	579	10	cells	cell	NNS
cord-265941-eff4le0g	579	11	RIPK4	RIPK4	NNP
cord-265941-eff4le0g	579	12	activates	activate	VBZ
cord-265941-eff4le0g	579	13	an	an	DT
cord-265941-eff4le0g	579	14	IRF6-mediated	irf6-mediated	JJ
cord-265941-eff4le0g	579	15	proinflammatory	proinflammatory	JJ
cord-265941-eff4le0g	579	16	cytokine	cytokine	NN
cord-265941-eff4le0g	579	17	response	response	NN
cord-265941-eff4le0g	579	18	in	in	IN
cord-265941-eff4le0g	579	19	keratinocytes	keratinocyte	NNS
cord-265941-eff4le0g	579	20	RIP4	RIP4	NNP
cord-265941-eff4le0g	579	21	(	(	-LRB-
cord-265941-eff4le0g	579	22	DIK	DIK	NNP
cord-265941-eff4le0g	579	23	/	/	SYM
cord-265941-eff4le0g	579	24	PKK	PKK	NNP
cord-265941-eff4le0g	579	25	)	)	-RRB-
cord-265941-eff4le0g	579	26	,	,	,
cord-265941-eff4le0g	579	27	a	a	DT
cord-265941-eff4le0g	579	28	novel	novel	JJ
cord-265941-eff4le0g	579	29	member	member	NN
cord-265941-eff4le0g	579	30	of	of	IN
cord-265941-eff4le0g	579	31	the	the	DT
cord-265941-eff4le0g	579	32	RIP	RIP	NNP
cord-265941-eff4le0g	579	33	kinase	kinase	NN
cord-265941-eff4le0g	579	34	family	family	NN
cord-265941-eff4le0g	579	35	,	,	,
cord-265941-eff4le0g	579	36	activates	activate	VBZ
cord-265941-eff4le0g	579	37	NF	nf	NN
cord-265941-eff4le0g	579	38	-	-	HYPH
cord-265941-eff4le0g	579	39	kappa	kappa	NN
cord-265941-eff4le0g	579	40	B	b	NN
cord-265941-eff4le0g	579	41	and	and	CC
cord-265941-eff4le0g	579	42	is	be	VBZ
cord-265941-eff4le0g	579	43	processed	process	VBN
cord-265941-eff4le0g	579	44	during	during	IN
cord-265941-eff4le0g	579	45	apoptosis	apoptosis	NN
cord-265941-eff4le0g	579	46	for	for	IN
cord-265941-eff4le0g	579	47	the	the	DT
cord-265941-eff4le0g	579	48	Courage	Courage	NNP
cord-265941-eff4le0g	579	49	-	-	HYPH
cord-265941-eff4le0g	579	50	Pd	Pd	NNP
cord-265941-eff4le0g	579	51	Consortium	Consortium	NNP
cord-265941-eff4le0g	579	52	,	,	,
cord-265941-eff4le0g	579	53	t.	t.	NNP
cord-265941-eff4le0g	580	1	F.P.s	f.p.	NNS
cord-265941-eff4le0g	580	2	.	.	.
cord-265941-eff4le0g	581	1	D.	D.	NNP
cord-265941-eff4le0g	581	2	C	C	NNP
cord-265941-eff4le0g	581	3	,	,	,
cord-265941-eff4le0g	581	4	the	the	DT
cord-265941-eff4le0g	581	5	International	International	NNP
cord-265941-eff4le0g	581	6	Parkinson	Parkinson	NNP
cord-265941-eff4le0g	581	7	's	's	POS
cord-265941-eff4le0g	581	8	Disease	Disease	NNP
cord-265941-eff4le0g	581	9	Genomics	Genomics	NNP
cord-265941-eff4le0g	581	10	,	,	,
cord-265941-eff4le0g	581	11	C	C	NNP
cord-265941-eff4le0g	581	12	,	,	,
cord-265941-eff4le0g	581	13	Frequency	Frequency	NNP
cord-265941-eff4le0g	581	14	of	of	IN
cord-265941-eff4le0g	581	15	loss	loss	NN
cord-265941-eff4le0g	581	16	of	of	IN
cord-265941-eff4le0g	581	17	function	function	NN
cord-265941-eff4le0g	581	18	variants	variant	NNS
cord-265941-eff4le0g	581	19	in	in	IN
cord-265941-eff4le0g	581	20	LRRK2	lrrk2	NN
cord-265941-eff4le0g	582	1	in	in	IN
cord-265941-eff4le0g	582	2	parkinson	parkinson	NNP
cord-265941-eff4le0g	582	3	disease	disease	NNP
cord-265941-eff4le0g	583	1	Transcriptome	Transcriptome	NNP
cord-265941-eff4le0g	583	2	analysis	analysis	NN
cord-265941-eff4le0g	583	3	reveals	reveal	VBZ
cord-265941-eff4le0g	583	4	differential	differential	JJ
cord-265941-eff4le0g	583	5	immune	immune	JJ
cord-265941-eff4le0g	583	6	related	relate	VBN
cord-265941-eff4le0g	583	7	genes	gene	NNS
cord-265941-eff4le0g	583	8	expression	expression	NN
cord-265941-eff4le0g	583	9	in	in	IN
cord-265941-eff4le0g	583	10	bovine	bovine	JJ
cord-265941-eff4le0g	583	11	viral	viral	JJ
cord-265941-eff4le0g	583	12	diarrhea	diarrhea	NN
cord-265941-eff4le0g	583	13	virus-2	virus-2	NNP
cord-265941-eff4le0g	583	14	infected	infected	JJ
cord-265941-eff4le0g	583	15	goat	goat	NN
cord-265941-eff4le0g	583	16	peripheral	peripheral	JJ
cord-265941-eff4le0g	583	17	blood	blood	NN
cord-265941-eff4le0g	583	18	mononuclear	mononuclear	NN
cord-265941-eff4le0g	583	19	cells	cell	NNS
cord-265941-eff4le0g	583	20	(	(	-LRB-
cord-265941-eff4le0g	583	21	PBMCs	pbmc	NNS
cord-265941-eff4le0g	583	22	)	)	-RRB-
cord-265941-eff4le0g	584	1	LRRK2	LRRK2	NNP
cord-265941-eff4le0g	585	1	at	at	IN
cord-265941-eff4le0g	585	2	the	the	DT
cord-265941-eff4le0g	585	3	interface	interface	NN
cord-265941-eff4le0g	585	4	of	of	IN
cord-265941-eff4le0g	585	5	autophagosomes	autophagosomes	NNP
cord-265941-eff4le0g	585	6	,	,	,
cord-265941-eff4le0g	585	7	endosomes	endosome	NNS
cord-265941-eff4le0g	585	8	and	and	CC
cord-265941-eff4le0g	585	9	lysosomes	lysosome	NNS
cord-265941-eff4le0g	586	1	LRRK2	LRRK2	NNP
cord-265941-eff4le0g	587	1	is	be	VBZ
cord-265941-eff4le0g	587	2	involved	involve	VBN
cord-265941-eff4le0g	587	3	in	in	IN
cord-265941-eff4le0g	587	4	the	the	DT
cord-265941-eff4le0g	587	5	IFNgamma	IFNgamma	NNP
cord-265941-eff4le0g	587	6	response	response	NN
cord-265941-eff4le0g	587	7	and	and	CC
cord-265941-eff4le0g	587	8	host	host	NN
cord-265941-eff4le0g	587	9	response	response	NN
cord-265941-eff4le0g	587	10	to	to	IN
cord-265941-eff4le0g	587	11	pathogens	pathogen	NNS
cord-265941-eff4le0g	588	1	LRRK2	LRRK2	NNP
cord-265941-eff4le0g	588	2	promotes	promote	VBZ
cord-265941-eff4le0g	588	3	the	the	DT
cord-265941-eff4le0g	588	4	activation	activation	NN
cord-265941-eff4le0g	588	5	of	of	IN
cord-265941-eff4le0g	588	6	NLRC4	NLRC4	NNP
cord-265941-eff4le0g	588	7	inflammasome	inflammasome	NNP
cord-265941-eff4le0g	588	8	during	during	IN
cord-265941-eff4le0g	588	9	Salmonella	Salmonella	NNP
cord-265941-eff4le0g	588	10	typhimurium	typhimurium	NN
cord-265941-eff4le0g	588	11	infection	infection	NN
cord-265941-eff4le0g	589	1	Commensal	Commensal	NNP
cord-265941-eff4le0g	589	2	bacteria	bacteria	NNS
cord-265941-eff4le0g	589	3	direct	direct	JJ
cord-265941-eff4le0g	589	4	selective	selective	JJ
cord-265941-eff4le0g	589	5	cargo	cargo	NN
cord-265941-eff4le0g	589	6	sorting	sorting	NN
cord-265941-eff4le0g	589	7	to	to	TO
cord-265941-eff4le0g	589	8	promote	promote	VB
cord-265941-eff4le0g	589	9	symbiosis	symbiosis	NN
cord-265941-eff4le0g	590	1	The	the	DT
cord-265941-eff4le0g	590	2	kinase	kinase	NN
cord-265941-eff4le0g	590	3	LRRK2	lrrk2	NN
cord-265941-eff4le0g	590	4	is	be	VBZ
cord-265941-eff4le0g	590	5	a	a	DT
cord-265941-eff4le0g	590	6	regulator	regulator	NN
cord-265941-eff4le0g	590	7	of	of	IN
cord-265941-eff4le0g	590	8	the	the	DT
cord-265941-eff4le0g	590	9	transcription	transcription	NN
cord-265941-eff4le0g	590	10	factor	factor	NN
cord-265941-eff4le0g	590	11	NFAT	NFAT	NNP
cord-265941-eff4le0g	590	12	that	that	WDT
cord-265941-eff4le0g	590	13	modulates	modulate	VBZ
cord-265941-eff4le0g	590	14	the	the	DT
cord-265941-eff4le0g	590	15	severity	severity	NN
cord-265941-eff4le0g	590	16	of	of	IN
cord-265941-eff4le0g	590	17	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	590	18	bowel	bowel	NN
cord-265941-eff4le0g	590	19	disease	disease	NN
cord-265941-eff4le0g	591	1	A	a	DT
cord-265941-eff4le0g	591	2	missense	missense	JJ
cord-265941-eff4le0g	591	3	LRRK2	lrrk2	NN
cord-265941-eff4le0g	591	4	variant	variant	NN
cord-265941-eff4le0g	591	5	is	be	VBZ
cord-265941-eff4le0g	591	6	a	a	DT
cord-265941-eff4le0g	591	7	risk	risk	NN
cord-265941-eff4le0g	591	8	factor	factor	NN
cord-265941-eff4le0g	591	9	for	for	IN
cord-265941-eff4le0g	591	10	excessive	excessive	JJ
cord-265941-eff4le0g	591	11	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	591	12	responses	response	NNS
cord-265941-eff4le0g	591	13	in	in	IN
cord-265941-eff4le0g	591	14	leprosy	leprosy	NN
cord-265941-eff4le0g	591	15	Association	Association	NNP
cord-265941-eff4le0g	591	16	of	of	IN
cord-265941-eff4le0g	591	17	the	the	DT
cord-265941-eff4le0g	591	18	LRRK2	lrrk2	NN
cord-265941-eff4le0g	591	19	genetic	genetic	JJ
cord-265941-eff4le0g	591	20	polymorphisms	polymorphism	NNS
cord-265941-eff4le0g	591	21	with	with	IN
cord-265941-eff4le0g	591	22	leprosy	leprosy	NN
cord-265941-eff4le0g	591	23	in	in	IN
cord-265941-eff4le0g	591	24	Han	Han	NNP
cord-265941-eff4le0g	591	25	Chinese	Chinese	NNP
cord-265941-eff4le0g	591	26	from	from	IN
cord-265941-eff4le0g	591	27	Southwest	Southwest	NNP
cord-265941-eff4le0g	591	28	China	China	NNP
cord-265941-eff4le0g	591	29	Meta	Meta	NNP
cord-265941-eff4le0g	591	30	-	-	HYPH
cord-265941-eff4le0g	591	31	analysis	analysis	NN
cord-265941-eff4le0g	591	32	of	of	IN
cord-265941-eff4le0g	591	33	human	human	JJ
cord-265941-eff4le0g	591	34	gene	gene	NN
cord-265941-eff4le0g	591	35	expression	expression	NN
cord-265941-eff4le0g	591	36	in	in	IN
cord-265941-eff4le0g	591	37	response	response	NN
cord-265941-eff4le0g	591	38	to	to	IN
cord-265941-eff4le0g	591	39	Mycobacterium	Mycobacterium	NNP
cord-265941-eff4le0g	591	40	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	591	41	infection	infection	NN
cord-265941-eff4le0g	591	42	reveals	reveal	VBZ
cord-265941-eff4le0g	591	43	potential	potential	JJ
cord-265941-eff4le0g	591	44	therapeutic	therapeutic	JJ
cord-265941-eff4le0g	591	45	targets	target	NNS
cord-265941-eff4le0g	592	1	LRRK2	LRRK2	NNP
cord-265941-eff4le0g	592	2	is	be	VBZ
cord-265941-eff4le0g	592	3	a	a	DT
cord-265941-eff4le0g	592	4	negative	negative	JJ
cord-265941-eff4le0g	592	5	regulator	regulator	NN
cord-265941-eff4le0g	592	6	of	of	IN
cord-265941-eff4le0g	592	7	Mycobacterium	Mycobacterium	NNP
cord-265941-eff4le0g	592	8	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	592	9	phagosome	phagosome	NN
cord-265941-eff4le0g	592	10	maturation	maturation	NN
cord-265941-eff4le0g	592	11	in	in	IN
cord-265941-eff4le0g	592	12	macrophages	macrophage	NNS
cord-265941-eff4le0g	593	1	LRRK2	LRRK2	NNP
cord-265941-eff4le0g	593	2	maintains	maintain	VBZ
cord-265941-eff4le0g	593	3	mitochondrial	mitochondrial	JJ
cord-265941-eff4le0g	593	4	homeostasis	homeostasis	NN
cord-265941-eff4le0g	593	5	and	and	CC
cord-265941-eff4le0g	593	6	regulates	regulate	VBZ
cord-265941-eff4le0g	593	7	innate	innate	JJ
cord-265941-eff4le0g	593	8	immune	immune	JJ
cord-265941-eff4le0g	593	9	responses	response	NNS
cord-265941-eff4le0g	593	10	to	to	IN
cord-265941-eff4le0g	593	11	Mycobacterium	Mycobacterium	NNP
cord-265941-eff4le0g	593	12	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	593	13	Genome	Genome	NNP
cord-265941-eff4le0g	593	14	-	-	HYPH
cord-265941-eff4le0g	593	15	wide	wide	JJ
cord-265941-eff4le0g	593	16	expression	expression	NN
cord-265941-eff4le0g	593	17	profiling	profiling	NN
cord-265941-eff4le0g	594	1	identifies	identify	VBZ
cord-265941-eff4le0g	594	2	type	type	NN
cord-265941-eff4le0g	594	3	1	1	CD
cord-265941-eff4le0g	594	4	interferon	interferon	NN
cord-265941-eff4le0g	594	5	response	response	NN
cord-265941-eff4le0g	594	6	pathways	pathway	NNS
cord-265941-eff4le0g	594	7	in	in	IN
cord-265941-eff4le0g	594	8	active	active	JJ
cord-265941-eff4le0g	594	9	tuberculosis	tuberculosis	NN
cord-265941-eff4le0g	594	10	Leucine	leucine	NN
cord-265941-eff4le0g	594	11	rich	rich	JJ
cord-265941-eff4le0g	594	12	repeat	repeat	NN
cord-265941-eff4le0g	594	13	kinase	kinase	NN
cord-265941-eff4le0g	594	14	2	2	CD
cord-265941-eff4le0g	594	15	and	and	CC
cord-265941-eff4le0g	594	16	innate	innate	JJ
cord-265941-eff4le0g	594	17	immunity	immunity	NN
cord-265941-eff4le0g	594	18	Membrane	membrane	NN
cord-265941-eff4le0g	594	19	recruitment	recruitment	NN
cord-265941-eff4le0g	594	20	of	of	IN
cord-265941-eff4le0g	594	21	endogenous	endogenous	JJ
cord-265941-eff4le0g	594	22	LRRK2	lrrk2	NN
cord-265941-eff4le0g	594	23	precedes	precede	VBZ
cord-265941-eff4le0g	594	24	its	-PRON-	PRP$
cord-265941-eff4le0g	594	25	potent	potent	JJ
cord-265941-eff4le0g	594	26	regulation	regulation	NN
cord-265941-eff4le0g	594	27	of	of	IN
cord-265941-eff4le0g	594	28	autophagy	autophagy	NN
cord-265941-eff4le0g	594	29	Molecular	molecular	JJ
cord-265941-eff4le0g	594	30	mechanisms	mechanism	NNS
cord-265941-eff4le0g	594	31	and	and	CC
cord-265941-eff4le0g	594	32	functions	function	NNS
cord-265941-eff4le0g	594	33	of	of	IN
cord-265941-eff4le0g	594	34	pyroptosis	pyroptosis	NN
cord-265941-eff4le0g	594	35	,	,	,
cord-265941-eff4le0g	594	36	inflammatory	inflammatory	JJ
cord-265941-eff4le0g	594	37	caspases	caspase	NNS
cord-265941-eff4le0g	594	38	and	and	CC
cord-265941-eff4le0g	594	39	inflammasomes	inflammasome	NNS
cord-265941-eff4le0g	594	40	in	in	IN
cord-265941-eff4le0g	594	41	infectious	infectious	JJ
cord-265941-eff4le0g	594	42	diseases	disease	NNS
cord-265941-eff4le0g	595	1	Inhibitors	inhibitor	NNS
cord-265941-eff4le0g	595	2	targeting	target	VBG
cord-265941-eff4le0g	595	3	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	595	4	/	/	SYM
cord-265941-eff4le0g	595	5	RIPK3	ripk3	XX
cord-265941-eff4le0g	595	6	:	:	:
cord-265941-eff4le0g	595	7	old	old	JJ
cord-265941-eff4le0g	595	8	and	and	CC
cord-265941-eff4le0g	595	9	new	new	JJ
cord-265941-eff4le0g	596	1	drugs	drug	NNS
cord-265941-eff4le0g	596	2	Extended	extend	VBD
cord-265941-eff4le0g	596	3	pharmacodynamic	pharmacodynamic	JJ
cord-265941-eff4le0g	596	4	responses	response	NNS
cord-265941-eff4le0g	596	5	observed	observe	VBN
cord-265941-eff4le0g	596	6	upon	upon	IN
cord-265941-eff4le0g	596	7	PROTAC	PROTAC	NNP
cord-265941-eff4le0g	596	8	-	-	HYPH
cord-265941-eff4le0g	596	9	mediated	mediate	VBN
cord-265941-eff4le0g	596	10	degradation	degradation	NN
cord-265941-eff4le0g	596	11	of	of	IN
cord-265941-eff4le0g	596	12	RIPK2	RIPK2	NNP
cord-265941-eff4le0g	596	13	Induction	Induction	NNP
cord-265941-eff4le0g	596	14	of	of	IN
cord-265941-eff4le0g	596	15	necroptotic	necroptotic	JJ
cord-265941-eff4le0g	596	16	cell	cell	NN
cord-265941-eff4le0g	596	17	death	death	NN
cord-265941-eff4le0g	596	18	by	by	IN
cord-265941-eff4le0g	596	19	viral	viral	JJ
cord-265941-eff4le0g	596	20	activation	activation	NN
cord-265941-eff4le0g	596	21	of	of	IN
cord-265941-eff4le0g	596	22	the	the	DT
cord-265941-eff4le0g	596	23	RIG	rig	NN
cord-265941-eff4le0g	596	24	-	-	:
cord-265941-eff4le0g	596	25	I	-PRON-	PRP
cord-265941-eff4le0g	596	26	or	or	CC
cord-265941-eff4le0g	596	27	STING	sting	VB
cord-265941-eff4le0g	596	28	pathway	pathway	NN
cord-265941-eff4le0g	596	29	Depletion	depletion	NN
cord-265941-eff4le0g	596	30	of	of	IN
cord-265941-eff4le0g	596	31	RIPK1	RIPK1	NNS
cord-265941-eff4le0g	596	32	in	in	IN
cord-265941-eff4le0g	596	33	hepatocytes	hepatocyte	NNS
cord-265941-eff4le0g	596	34	exacerbates	exacerbate	VBZ
cord-265941-eff4le0g	596	35	liver	liver	NN
cord-265941-eff4le0g	596	36	damage	damage	NN
cord-265941-eff4le0g	596	37	in	in	IN
cord-265941-eff4le0g	596	38	fulminant	fulminant	JJ
cord-265941-eff4le0g	596	39	viral	viral	JJ
cord-265941-eff4le0g	596	40	hepatitis	hepatitis	NN
cord-265941-eff4le0g	596	41	Reovirus	Reovirus	NNP
cord-265941-eff4le0g	596	42	activates	activate	VBZ
cord-265941-eff4le0g	596	43	a	a	DT
cord-265941-eff4le0g	596	44	caspase	caspase	JJ
cord-265941-eff4le0g	596	45	-	-	HYPH
cord-265941-eff4le0g	596	46	independent	independent	JJ
cord-265941-eff4le0g	596	47	cell	cell	NN
cord-265941-eff4le0g	596	48	death	death	NN
cord-265941-eff4le0g	596	49	pathway	pathway	NN
cord-265941-eff4le0g	596	50	Viral	Viral	NNP
cord-265941-eff4le0g	596	51	RNA	RNA	NNP
cord-265941-eff4le0g	596	52	at	at	IN
cord-265941-eff4le0g	596	53	two	two	CD
cord-265941-eff4le0g	596	54	stages	stage	NNS
cord-265941-eff4le0g	596	55	of	of	IN
cord-265941-eff4le0g	596	56	reovirus	reovirus	JJ
cord-265941-eff4le0g	596	57	infection	infection	NN
cord-265941-eff4le0g	596	58	is	be	VBZ
cord-265941-eff4le0g	596	59	required	require	VBN
cord-265941-eff4le0g	596	60	for	for	IN
cord-265941-eff4le0g	596	61	the	the	DT
cord-265941-eff4le0g	596	62	induction	induction	NN
cord-265941-eff4le0g	596	63	of	of	IN
cord-265941-eff4le0g	596	64	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	597	1	The	the	DT
cord-265941-eff4le0g	597	2	NOD	NOD	NNP
cord-265941-eff4le0g	597	3	/	/	SYM
cord-265941-eff4le0g	597	4	RIP2	RIP2	NNP
cord-265941-eff4le0g	597	5	pathway	pathway	NN
cord-265941-eff4le0g	597	6	is	be	VBZ
cord-265941-eff4le0g	597	7	essential	essential	JJ
cord-265941-eff4le0g	597	8	for	for	IN
cord-265941-eff4le0g	597	9	host	host	NN
cord-265941-eff4le0g	597	10	defenses	defense	NNS
cord-265941-eff4le0g	597	11	against	against	IN
cord-265941-eff4le0g	597	12	Chlamydophila	Chlamydophila	NNP
cord-265941-eff4le0g	597	13	pneumoniae	pneumoniae	NN
cord-265941-eff4le0g	597	14	lung	lung	NN
cord-265941-eff4le0g	597	15	infection	infection	NN
cord-265941-eff4le0g	598	1	Receptor	receptor	NN
cord-265941-eff4le0g	598	2	-	-	HYPH
cord-265941-eff4le0g	598	3	interacting	interact	VBG
cord-265941-eff4le0g	598	4	serine	serine	NN
cord-265941-eff4le0g	598	5	/	/	SYM
cord-265941-eff4le0g	598	6	threonine	threonine	NN
cord-265941-eff4le0g	598	7	kinase	kinase	VBZ
cord-265941-eff4le0g	598	8	1-and	1-and	CD
cord-265941-eff4le0g	598	9	3-dependent	3-dependent	CD
cord-265941-eff4le0g	598	10	inflammation	inflammation	NN
cord-265941-eff4le0g	598	11	induced	induce	VBN
cord-265941-eff4le0g	598	12	in	in	IN
cord-265941-eff4le0g	598	13	lungs	lung	NNS
cord-265941-eff4le0g	598	14	of	of	IN
cord-265941-eff4le0g	598	15	chicken	chicken	NN
cord-265941-eff4le0g	598	16	infected	infect	VBN
cord-265941-eff4le0g	598	17	with	with	IN
cord-265941-eff4le0g	598	18	Pasteurella	Pasteurella	NNP
cord-265941-eff4le0g	598	19	multocida	multocida	NNP
cord-265941-eff4le0g	598	20	Leishmania	Leishmania	NNP
cord-265941-eff4le0g	598	21	braziliensis	braziliensis	NN
cord-265941-eff4le0g	598	22	subverts	subvert	VBZ
cord-265941-eff4le0g	598	23	necroptosis	necroptosis	NNP
cord-265941-eff4le0g	598	24	by	by	IN
cord-265941-eff4le0g	598	25	modulating	modulate	VBG
cord-265941-eff4le0g	598	26	RIPK3	ripk3	NN
cord-265941-eff4le0g	598	27	expression	expression	NN
cord-265941-eff4le0g	599	1	RIPK1-RIPK3-MLKL	ripk1-ripk3-mlkl	JJ
cord-265941-eff4le0g	599	2	-	-	HYPH
cord-265941-eff4le0g	599	3	Associated	associated	JJ
cord-265941-eff4le0g	599	4	necroptosis	necroptosis	NN
cord-265941-eff4le0g	599	5	drives	drive	VBZ
cord-265941-eff4le0g	599	6	leishmania	leishmania	NNP
cord-265941-eff4le0g	599	7	infantum	infantum	NNP
cord-265941-eff4le0g	599	8	killing	kill	VBG
cord-265941-eff4le0g	599	9	in	in	IN
cord-265941-eff4le0g	599	10	neutrophils	neutrophil	NNS
cord-265941-eff4le0g	599	11	RIPK1	ripk1	JJ
cord-265941-eff4le0g	600	1	and	and	CC
cord-265941-eff4le0g	600	2	PGAM5	pgam5	JJ
cord-265941-eff4le0g	600	3	control	control	NN
cord-265941-eff4le0g	600	4	leishmania	leishmania	NN
cord-265941-eff4le0g	600	5	replication	replication	NN
cord-265941-eff4le0g	600	6	through	through	IN
cord-265941-eff4le0g	600	7	distinct	distinct	JJ
cord-265941-eff4le0g	600	8	mechanisms	mechanism	NNS
cord-265941-eff4le0g	600	9	Involvement	Involvement	NNP
cord-265941-eff4le0g	600	10	of	of	IN
cord-265941-eff4le0g	600	11	Nod2	Nod2	NNP
cord-265941-eff4le0g	600	12	in	in	IN
cord-265941-eff4le0g	600	13	the	the	DT
cord-265941-eff4le0g	600	14	innate	innate	JJ
cord-265941-eff4le0g	600	15	immune	immune	JJ
cord-265941-eff4le0g	600	16	response	response	NN
cord-265941-eff4le0g	600	17	elicited	elicit	VBN
cord-265941-eff4le0g	600	18	by	by	IN
cord-265941-eff4le0g	600	19	malarial	malarial	JJ
cord-265941-eff4le0g	600	20	pigment	pigment	NN
cord-265941-eff4le0g	600	21	hemozoin	hemozoin	NNP
cord-265941-eff4le0g	600	22	Transcriptomic	Transcriptomic	NNP
cord-265941-eff4le0g	600	23	alterations	alteration	NNS
cord-265941-eff4le0g	600	24	in	in	IN
cord-265941-eff4le0g	600	25	Trypanosoma	Trypanosoma	NNP
cord-265941-eff4le0g	600	26	cruzi	cruzi	RB
cord-265941-eff4le0g	600	27	-	-	HYPH
cord-265941-eff4le0g	600	28	infected	infect	VBN
cord-265941-eff4le0g	600	29	cardiac	cardiac	NN
cord-265941-eff4le0g	600	30	myocytes	myocyte	NNS
cord-265941-eff4le0g	601	1	We	-PRON-	PRP
cord-265941-eff4le0g	601	2	would	would	MD
cord-265941-eff4le0g	601	3	like	like	VB
cord-265941-eff4le0g	601	4	to	to	TO
cord-265941-eff4le0g	601	5	acknowledge	acknowledge	VB
cord-265941-eff4le0g	601	6	Medina	Medina	NNP
cord-265941-eff4le0g	601	7	Pell	Pell	NNP
cord-265941-eff4le0g	601	8	for	for	IN
cord-265941-eff4le0g	601	9	her	-PRON-	PRP$
cord-265941-eff4le0g	601	10	assistance	assistance	NN
cord-265941-eff4le0g	601	11	with	with	IN
cord-265941-eff4le0g	601	12	assembling	assemble	VBG
cord-265941-eff4le0g	601	13	the	the	DT
cord-265941-eff4le0g	601	14	manuscript	manuscript	NN
cord-265941-eff4le0g	601	15	.	.	.