id	sid	tid	token	lemma	pos
cord-261028-sxux2ujo	1	1	key	key	JJ
cord-261028-sxux2ujo	2	1	:	:	:
cord-261028-sxux2ujo	2	2	cord-261028-sxux2ujo	cord-261028-sxux2ujo	NN
cord-261028-sxux2ujo	2	3	authors	author	NNS
cord-261028-sxux2ujo	2	4	:	:	:
cord-261028-sxux2ujo	2	5	Vatner	Vatner	NNP
cord-261028-sxux2ujo	2	6	,	,	,
cord-261028-sxux2ujo	2	7	Ralph	Ralph	NNP
cord-261028-sxux2ujo	2	8	E.	E.	NNP
cord-261028-sxux2ujo	2	9	;	;	:
cord-261028-sxux2ujo	2	10	Janssen	Janssen	NNP
cord-261028-sxux2ujo	2	11	,	,	,
cord-261028-sxux2ujo	2	12	Edith	Edith	NNP
cord-261028-sxux2ujo	2	13	M.	M.	NNP
cord-261028-sxux2ujo	2	14	title	title	NN
cord-261028-sxux2ujo	2	15	:	:	:
cord-261028-sxux2ujo	2	16	STING	sting	NN
cord-261028-sxux2ujo	2	17	,	,	,
cord-261028-sxux2ujo	2	18	DCs	dc	NNS
cord-261028-sxux2ujo	2	19	and	and	CC
cord-261028-sxux2ujo	2	20	the	the	DT
cord-261028-sxux2ujo	2	21	link	link	NN
cord-261028-sxux2ujo	2	22	between	between	IN
cord-261028-sxux2ujo	2	23	innate	innate	JJ
cord-261028-sxux2ujo	2	24	and	and	CC
cord-261028-sxux2ujo	2	25	adaptive	adaptive	JJ
cord-261028-sxux2ujo	2	26	tumor	tumor	NN
cord-261028-sxux2ujo	2	27	immunity	immunity	NN
cord-261028-sxux2ujo	2	28	date	date	NN
cord-261028-sxux2ujo	2	29	:	:	:
cord-261028-sxux2ujo	2	30	2017	2017	CD
cord-261028-sxux2ujo	2	31	-	-	HYPH
cord-261028-sxux2ujo	2	32	12	12	CD
cord-261028-sxux2ujo	2	33	-	-	SYM
cord-261028-sxux2ujo	2	34	20	20	CD
cord-261028-sxux2ujo	2	35	journal	journal	NN
cord-261028-sxux2ujo	2	36	:	:	:
cord-261028-sxux2ujo	3	1	Mol	Mol	NNP
cord-261028-sxux2ujo	3	2	Immunol	Immunol	NNP
cord-261028-sxux2ujo	3	3	DOI	doi	NN
cord-261028-sxux2ujo	3	4	:	:	:
cord-261028-sxux2ujo	3	5	10.1016/	10.1016/	CD
cord-261028-sxux2ujo	4	1	j.molimm.2017.12.001	j.molimm.2017.12.001	NNP
cord-261028-sxux2ujo	4	2	sha	sha	XX
cord-261028-sxux2ujo	4	3	:	:	:
cord-261028-sxux2ujo	5	1	10d5a17a8cfc4407042a218f9d7acb53c41056e2	10d5a17a8cfc4407042a218f9d7acb53c41056e2	NNS
cord-261028-sxux2ujo	5	2	doc_id	doc_id	CD
cord-261028-sxux2ujo	5	3	:	:	:
cord-261028-sxux2ujo	6	1	261028	261028	CD
cord-261028-sxux2ujo	6	2	cord_uid	cord_uid	NNS
cord-261028-sxux2ujo	6	3	:	:	:
cord-261028-sxux2ujo	7	1	sxux2ujo	sxux2ujo	NN
cord-261028-sxux2ujo	7	2	Cancer	Cancer	NNP
cord-261028-sxux2ujo	7	3	and	and	CC
cord-261028-sxux2ujo	7	4	the	the	DT
cord-261028-sxux2ujo	7	5	immune	immune	JJ
cord-261028-sxux2ujo	7	6	system	system	NN
cord-261028-sxux2ujo	7	7	are	be	VBP
cord-261028-sxux2ujo	7	8	intimately	intimately	RB
cord-261028-sxux2ujo	7	9	related	relate	VBN
cord-261028-sxux2ujo	7	10	.	.	.
cord-261028-sxux2ujo	8	1	Much	much	JJ
cord-261028-sxux2ujo	8	2	of	of	IN
cord-261028-sxux2ujo	8	3	the	the	DT
cord-261028-sxux2ujo	8	4	bulk	bulk	NN
cord-261028-sxux2ujo	8	5	of	of	IN
cord-261028-sxux2ujo	8	6	tumors	tumor	NNS
cord-261028-sxux2ujo	8	7	is	be	VBZ
cord-261028-sxux2ujo	8	8	comprised	comprise	VBN
cord-261028-sxux2ujo	8	9	of	of	IN
cord-261028-sxux2ujo	8	10	stromal	stromal	JJ
cord-261028-sxux2ujo	8	11	leukocytes	leukocyte	NNS
cord-261028-sxux2ujo	8	12	with	with	IN
cord-261028-sxux2ujo	8	13	immune	immune	JJ
cord-261028-sxux2ujo	8	14	functions	function	NNS
cord-261028-sxux2ujo	8	15	,	,	,
cord-261028-sxux2ujo	8	16	which	which	WDT
cord-261028-sxux2ujo	8	17	serve	serve	VBP
cord-261028-sxux2ujo	8	18	to	to	IN
cord-261028-sxux2ujo	8	19	both	both	DT
cord-261028-sxux2ujo	8	20	promote	promote	VB
cord-261028-sxux2ujo	8	21	and	and	CC
cord-261028-sxux2ujo	8	22	inhibit	inhibit	VB
cord-261028-sxux2ujo	8	23	tumor	tumor	NN
cord-261028-sxux2ujo	8	24	growth	growth	NN
cord-261028-sxux2ujo	8	25	,	,	,
cord-261028-sxux2ujo	8	26	invasion	invasion	NN
cord-261028-sxux2ujo	8	27	and	and	CC
cord-261028-sxux2ujo	8	28	metastasis	metastasis	NN
cord-261028-sxux2ujo	8	29	.	.	.
cord-261028-sxux2ujo	9	1	The	the	DT
cord-261028-sxux2ujo	9	2	T	t	NN
cord-261028-sxux2ujo	9	3	lymphocytes	lymphocyte	NNS
cord-261028-sxux2ujo	9	4	of	of	IN
cord-261028-sxux2ujo	9	5	the	the	DT
cord-261028-sxux2ujo	9	6	adaptive	adaptive	JJ
cord-261028-sxux2ujo	9	7	immune	immune	JJ
cord-261028-sxux2ujo	9	8	system	system	NN
cord-261028-sxux2ujo	9	9	are	be	VBP
cord-261028-sxux2ujo	9	10	essential	essential	JJ
cord-261028-sxux2ujo	9	11	for	for	IN
cord-261028-sxux2ujo	9	12	tumor	tumor	NN
cord-261028-sxux2ujo	9	13	immunity	immunity	NN
cord-261028-sxux2ujo	9	14	,	,	,
cord-261028-sxux2ujo	9	15	and	and	CC
cord-261028-sxux2ujo	9	16	these	these	DT
cord-261028-sxux2ujo	9	17	T	t	NN
cord-261028-sxux2ujo	9	18	cells	cell	NNS
cord-261028-sxux2ujo	9	19	are	be	VBP
cord-261028-sxux2ujo	9	20	generated	generate	VBN
cord-261028-sxux2ujo	9	21	by	by	IN
cord-261028-sxux2ujo	9	22	cross	cross	NN
cord-261028-sxux2ujo	9	23	-	-	JJ
cord-261028-sxux2ujo	9	24	priming	priming	NN
cord-261028-sxux2ujo	9	25	against	against	IN
cord-261028-sxux2ujo	9	26	tumor	tumor	NN
cord-261028-sxux2ujo	9	27	associated	associate	VBN
cord-261028-sxux2ujo	9	28	antigens	antigen	NNS
cord-261028-sxux2ujo	9	29	.	.	.
cord-261028-sxux2ujo	10	1	Dendritic	dendritic	JJ
cord-261028-sxux2ujo	10	2	cells	cell	NNS
cord-261028-sxux2ujo	10	3	(	(	-LRB-
cord-261028-sxux2ujo	10	4	DCs	DCs	NNP
cord-261028-sxux2ujo	10	5	)	)	-RRB-
cord-261028-sxux2ujo	10	6	are	be	VBP
cord-261028-sxux2ujo	10	7	essential	essential	JJ
cord-261028-sxux2ujo	10	8	in	in	IN
cord-261028-sxux2ujo	10	9	this	this	DT
cord-261028-sxux2ujo	10	10	process	process	NN
cord-261028-sxux2ujo	10	11	,	,	,
cord-261028-sxux2ujo	10	12	serving	serve	VBG
cord-261028-sxux2ujo	10	13	as	as	IN
cord-261028-sxux2ujo	10	14	the	the	DT
cord-261028-sxux2ujo	10	15	cellular	cellular	JJ
cord-261028-sxux2ujo	10	16	link	link	NN
cord-261028-sxux2ujo	10	17	between	between	IN
cord-261028-sxux2ujo	10	18	innate	innate	JJ
cord-261028-sxux2ujo	10	19	and	and	CC
cord-261028-sxux2ujo	10	20	adaptive	adaptive	JJ
cord-261028-sxux2ujo	10	21	immunity	immunity	NN
cord-261028-sxux2ujo	10	22	.	.	.
cord-261028-sxux2ujo	11	1	As	as	IN
cord-261028-sxux2ujo	11	2	a	a	DT
cord-261028-sxux2ujo	11	3	prerequisite	prerequisite	NN
cord-261028-sxux2ujo	11	4	for	for	IN
cord-261028-sxux2ujo	11	5	priming	priming	NN
cord-261028-sxux2ujo	11	6	of	of	IN
cord-261028-sxux2ujo	11	7	adaptive	adaptive	JJ
cord-261028-sxux2ujo	11	8	immune	immune	JJ
cord-261028-sxux2ujo	11	9	responses	response	NNS
cord-261028-sxux2ujo	11	10	,	,	,
cord-261028-sxux2ujo	11	11	DCs	DCs	NNP
cord-261028-sxux2ujo	11	12	must	must	MD
cord-261028-sxux2ujo	11	13	take	take	VB
cord-261028-sxux2ujo	11	14	up	up	RP
cord-261028-sxux2ujo	11	15	tumor	tumor	NN
cord-261028-sxux2ujo	11	16	antigens	antigen	NNS
cord-261028-sxux2ujo	11	17	,	,	,
cord-261028-sxux2ujo	11	18	process	process	VB
cord-261028-sxux2ujo	11	19	them	-PRON-	PRP
cord-261028-sxux2ujo	11	20	and	and	CC
cord-261028-sxux2ujo	11	21	present	present	VB
cord-261028-sxux2ujo	11	22	them	-PRON-	PRP
cord-261028-sxux2ujo	11	23	in	in	IN
cord-261028-sxux2ujo	11	24	the	the	DT
cord-261028-sxux2ujo	11	25	context	context	NN
cord-261028-sxux2ujo	11	26	of	of	IN
cord-261028-sxux2ujo	11	27	the	the	DT
cord-261028-sxux2ujo	11	28	major	major	JJ
cord-261028-sxux2ujo	11	29	histocompatibility	histocompatibility	NN
cord-261028-sxux2ujo	11	30	complex	complex	NN
cord-261028-sxux2ujo	11	31	(	(	-LRB-
cord-261028-sxux2ujo	11	32	MHC	MHC	NNP
cord-261028-sxux2ujo	11	33	)	)	-RRB-
cord-261028-sxux2ujo	11	34	.	.	.
cord-261028-sxux2ujo	12	1	DCs	DCs	NNP
cord-261028-sxux2ujo	12	2	also	also	RB
cord-261028-sxux2ujo	12	3	serve	serve	VBP
cord-261028-sxux2ujo	12	4	as	as	IN
cord-261028-sxux2ujo	12	5	sensors	sensor	NNS
cord-261028-sxux2ujo	12	6	of	of	IN
cord-261028-sxux2ujo	12	7	innate	innate	JJ
cord-261028-sxux2ujo	12	8	activation	activation	NN
cord-261028-sxux2ujo	12	9	signals	signal	NNS
cord-261028-sxux2ujo	12	10	from	from	IN
cord-261028-sxux2ujo	12	11	cancer	cancer	NN
cord-261028-sxux2ujo	12	12	that	that	WDT
cord-261028-sxux2ujo	12	13	are	be	VBP
cord-261028-sxux2ujo	12	14	necessary	necessary	JJ
cord-261028-sxux2ujo	12	15	for	for	IN
cord-261028-sxux2ujo	12	16	their	-PRON-	PRP$
cord-261028-sxux2ujo	12	17	activation	activation	NN
cord-261028-sxux2ujo	12	18	and	and	CC
cord-261028-sxux2ujo	12	19	effective	effective	JJ
cord-261028-sxux2ujo	12	20	priming	priming	NN
cord-261028-sxux2ujo	12	21	of	of	IN
cord-261028-sxux2ujo	12	22	cancer	cancer	NN
cord-261028-sxux2ujo	12	23	specific	specific	JJ
cord-261028-sxux2ujo	12	24	T	t	NN
cord-261028-sxux2ujo	12	25	cells	cell	NNS
cord-261028-sxux2ujo	12	26	.	.	.
cord-261028-sxux2ujo	13	1	Here	here	RB
cord-261028-sxux2ujo	13	2	we	-PRON-	PRP
cord-261028-sxux2ujo	13	3	discuss	discuss	VBP
cord-261028-sxux2ujo	13	4	the	the	DT
cord-261028-sxux2ujo	13	5	role	role	NN
cord-261028-sxux2ujo	13	6	of	of	IN
cord-261028-sxux2ujo	13	7	DCs	dc	NNS
cord-261028-sxux2ujo	13	8	in	in	IN
cord-261028-sxux2ujo	13	9	the	the	DT
cord-261028-sxux2ujo	13	10	sensing	sensing	NN
cord-261028-sxux2ujo	13	11	of	of	IN
cord-261028-sxux2ujo	13	12	cancer	cancer	NN
cord-261028-sxux2ujo	13	13	and	and	CC
cord-261028-sxux2ujo	13	14	in	in	IN
cord-261028-sxux2ujo	13	15	priming	prime	VBG
cord-261028-sxux2ujo	13	16	the	the	DT
cord-261028-sxux2ujo	13	17	adaptive	adaptive	JJ
cord-261028-sxux2ujo	13	18	response	response	NN
cord-261028-sxux2ujo	13	19	against	against	IN
cord-261028-sxux2ujo	13	20	tumors	tumor	NNS
cord-261028-sxux2ujo	13	21	.	.	.
cord-261028-sxux2ujo	14	1	Furthermore	furthermore	RB
cord-261028-sxux2ujo	14	2	,	,	,
cord-261028-sxux2ujo	14	3	we	-PRON-	PRP
cord-261028-sxux2ujo	14	4	present	present	VBP
cord-261028-sxux2ujo	14	5	the	the	DT
cord-261028-sxux2ujo	14	6	essential	essential	JJ
cord-261028-sxux2ujo	14	7	role	role	NN
cord-261028-sxux2ujo	14	8	of	of	IN
cord-261028-sxux2ujo	14	9	the	the	DT
cord-261028-sxux2ujo	14	10	Stimulator	Stimulator	NNP
cord-261028-sxux2ujo	14	11	of	of	IN
cord-261028-sxux2ujo	14	12	Interferon	Interferon	NNP
cord-261028-sxux2ujo	14	13	Genes	Genes	NNP
cord-261028-sxux2ujo	14	14	(	(	-LRB-
cord-261028-sxux2ujo	14	15	STING	STING	NNP
cord-261028-sxux2ujo	14	16	)	)	-RRB-
cord-261028-sxux2ujo	14	17	signaling	signal	VBG
cord-261028-sxux2ujo	14	18	pathway	pathway	NN
cord-261028-sxux2ujo	14	19	in	in	IN
cord-261028-sxux2ujo	14	20	producing	produce	VBG
cord-261028-sxux2ujo	14	21	type	type	NN
cord-261028-sxux2ujo	14	22	I	-PRON-	PRP
cord-261028-sxux2ujo	14	23	interferons	interferon	NNS
cord-261028-sxux2ujo	14	24	(	(	-LRB-
cord-261028-sxux2ujo	14	25	IFNs	ifns	NN
cord-261028-sxux2ujo	14	26	)	)	-RRB-
cord-261028-sxux2ujo	14	27	that	that	WDT
cord-261028-sxux2ujo	14	28	are	be	VBP
cord-261028-sxux2ujo	14	29	essential	essential	JJ
cord-261028-sxux2ujo	14	30	in	in	IN
cord-261028-sxux2ujo	14	31	this	this	DT
cord-261028-sxux2ujo	14	32	process	process	NN
cord-261028-sxux2ujo	14	33	.	.	.
cord-261028-sxux2ujo	15	1	Cancer	cancer	NN
cord-261028-sxux2ujo	15	2	and	and	CC
cord-261028-sxux2ujo	15	3	the	the	DT
cord-261028-sxux2ujo	15	4	immune	immune	JJ
cord-261028-sxux2ujo	15	5	system	system	NN
cord-261028-sxux2ujo	15	6	are	be	VBP
cord-261028-sxux2ujo	15	7	intimately	intimately	RB
cord-261028-sxux2ujo	15	8	related	relate	VBN
cord-261028-sxux2ujo	15	9	.	.	.
cord-261028-sxux2ujo	16	1	Much	much	JJ
cord-261028-sxux2ujo	16	2	of	of	IN
cord-261028-sxux2ujo	16	3	the	the	DT
cord-261028-sxux2ujo	16	4	bulk	bulk	NN
cord-261028-sxux2ujo	16	5	of	of	IN
cord-261028-sxux2ujo	16	6	tumors	tumor	NNS
cord-261028-sxux2ujo	16	7	is	be	VBZ
cord-261028-sxux2ujo	16	8	comprised	comprise	VBN
cord-261028-sxux2ujo	16	9	of	of	IN
cord-261028-sxux2ujo	16	10	stromal	stromal	JJ
cord-261028-sxux2ujo	16	11	leukocytes	leukocyte	NNS
cord-261028-sxux2ujo	16	12	with	with	IN
cord-261028-sxux2ujo	16	13	immune	immune	JJ
cord-261028-sxux2ujo	16	14	functions	function	NNS
cord-261028-sxux2ujo	16	15	,	,	,
cord-261028-sxux2ujo	16	16	which	which	WDT
cord-261028-sxux2ujo	16	17	serve	serve	VBP
cord-261028-sxux2ujo	16	18	to	to	IN
cord-261028-sxux2ujo	16	19	both	both	DT
cord-261028-sxux2ujo	16	20	promote	promote	VB
cord-261028-sxux2ujo	16	21	and	and	CC
cord-261028-sxux2ujo	16	22	inhibit	inhibit	VB
cord-261028-sxux2ujo	16	23	tumor	tumor	NN
cord-261028-sxux2ujo	16	24	growth	growth	NN
cord-261028-sxux2ujo	16	25	,	,	,
cord-261028-sxux2ujo	16	26	invasion	invasion	NN
cord-261028-sxux2ujo	16	27	and	and	CC
cord-261028-sxux2ujo	16	28	metastasis	metastasis	NN
cord-261028-sxux2ujo	16	29	.	.	.
cord-261028-sxux2ujo	17	1	The	the	DT
cord-261028-sxux2ujo	17	2	T	t	NN
cord-261028-sxux2ujo	17	3	lymphocytes	lymphocyte	NNS
cord-261028-sxux2ujo	17	4	of	of	IN
cord-261028-sxux2ujo	17	5	the	the	DT
cord-261028-sxux2ujo	17	6	adaptive	adaptive	JJ
cord-261028-sxux2ujo	17	7	immune	immune	JJ
cord-261028-sxux2ujo	17	8	system	system	NN
cord-261028-sxux2ujo	17	9	are	be	VBP
cord-261028-sxux2ujo	17	10	essential	essential	JJ
cord-261028-sxux2ujo	17	11	for	for	IN
cord-261028-sxux2ujo	17	12	tumor	tumor	NN
cord-261028-sxux2ujo	17	13	immunity	immunity	NN
cord-261028-sxux2ujo	17	14	,	,	,
cord-261028-sxux2ujo	17	15	and	and	CC
cord-261028-sxux2ujo	17	16	these	these	DT
cord-261028-sxux2ujo	17	17	T	t	NN
cord-261028-sxux2ujo	17	18	cells	cell	NNS
cord-261028-sxux2ujo	17	19	are	be	VBP
cord-261028-sxux2ujo	17	20	generated	generate	VBN
cord-261028-sxux2ujo	17	21	by	by	IN
cord-261028-sxux2ujo	17	22	cross	cross	NN
cord-261028-sxux2ujo	17	23	-	-	JJ
cord-261028-sxux2ujo	17	24	priming	priming	NN
cord-261028-sxux2ujo	17	25	against	against	IN
cord-261028-sxux2ujo	17	26	tumor	tumor	NN
cord-261028-sxux2ujo	17	27	associated	associate	VBN
cord-261028-sxux2ujo	17	28	antigens	antigen	NNS
cord-261028-sxux2ujo	17	29	.	.	.
cord-261028-sxux2ujo	18	1	Dendritic	dendritic	JJ
cord-261028-sxux2ujo	18	2	cells	cell	NNS
cord-261028-sxux2ujo	18	3	(	(	-LRB-
cord-261028-sxux2ujo	18	4	DCs	DCs	NNP
cord-261028-sxux2ujo	18	5	)	)	-RRB-
cord-261028-sxux2ujo	18	6	are	be	VBP
cord-261028-sxux2ujo	18	7	essential	essential	JJ
cord-261028-sxux2ujo	18	8	in	in	IN
cord-261028-sxux2ujo	18	9	this	this	DT
cord-261028-sxux2ujo	18	10	process	process	NN
cord-261028-sxux2ujo	18	11	,	,	,
cord-261028-sxux2ujo	18	12	serving	serve	VBG
cord-261028-sxux2ujo	18	13	as	as	IN
cord-261028-sxux2ujo	18	14	the	the	DT
cord-261028-sxux2ujo	18	15	cellular	cellular	JJ
cord-261028-sxux2ujo	18	16	link	link	NN
cord-261028-sxux2ujo	18	17	between	between	IN
cord-261028-sxux2ujo	18	18	innate	innate	JJ
cord-261028-sxux2ujo	18	19	and	and	CC
cord-261028-sxux2ujo	18	20	adaptive	adaptive	JJ
cord-261028-sxux2ujo	18	21	immunity	immunity	NN
cord-261028-sxux2ujo	18	22	.	.	.
cord-261028-sxux2ujo	19	1	As	as	IN
cord-261028-sxux2ujo	19	2	a	a	DT
cord-261028-sxux2ujo	19	3	prerequisite	prerequisite	NN
cord-261028-sxux2ujo	19	4	for	for	IN
cord-261028-sxux2ujo	19	5	priming	priming	NN
cord-261028-sxux2ujo	19	6	of	of	IN
cord-261028-sxux2ujo	19	7	adaptive	adaptive	JJ
cord-261028-sxux2ujo	19	8	immune	immune	JJ
cord-261028-sxux2ujo	19	9	responses	response	NNS
cord-261028-sxux2ujo	19	10	,	,	,
cord-261028-sxux2ujo	19	11	DCs	DCs	NNP
cord-261028-sxux2ujo	19	12	must	must	MD
cord-261028-sxux2ujo	19	13	take	take	VB
cord-261028-sxux2ujo	19	14	up	up	RP
cord-261028-sxux2ujo	19	15	tumor	tumor	NN
cord-261028-sxux2ujo	19	16	antigens	antigen	NNS
cord-261028-sxux2ujo	19	17	,	,	,
cord-261028-sxux2ujo	19	18	process	process	VB
cord-261028-sxux2ujo	19	19	them	-PRON-	PRP
cord-261028-sxux2ujo	19	20	and	and	CC
cord-261028-sxux2ujo	19	21	present	present	VB
cord-261028-sxux2ujo	19	22	them	-PRON-	PRP
cord-261028-sxux2ujo	19	23	in	in	IN
cord-261028-sxux2ujo	19	24	the	the	DT
cord-261028-sxux2ujo	19	25	context	context	NN
cord-261028-sxux2ujo	19	26	of	of	IN
cord-261028-sxux2ujo	19	27	the	the	DT
cord-261028-sxux2ujo	19	28	major	major	JJ
cord-261028-sxux2ujo	19	29	histocompatibility	histocompatibility	NN
cord-261028-sxux2ujo	19	30	complex	complex	NN
cord-261028-sxux2ujo	19	31	(	(	-LRB-
cord-261028-sxux2ujo	19	32	MHC	MHC	NNP
cord-261028-sxux2ujo	19	33	)	)	-RRB-
cord-261028-sxux2ujo	19	34	.	.	.
cord-261028-sxux2ujo	20	1	DCs	DCs	NNP
cord-261028-sxux2ujo	20	2	also	also	RB
cord-261028-sxux2ujo	20	3	serve	serve	VBP
cord-261028-sxux2ujo	20	4	as	as	IN
cord-261028-sxux2ujo	20	5	This	this	DT
cord-261028-sxux2ujo	20	6	is	be	VBZ
cord-261028-sxux2ujo	20	7	an	an	DT
cord-261028-sxux2ujo	20	8	open	open	JJ
cord-261028-sxux2ujo	20	9	access	access	NN
cord-261028-sxux2ujo	20	10	article	article	NN
cord-261028-sxux2ujo	20	11	under	under	IN
cord-261028-sxux2ujo	20	12	the	the	DT
cord-261028-sxux2ujo	20	13	CC	CC	NNP
cord-261028-sxux2ujo	20	14	BY	BY	NNP
cord-261028-sxux2ujo	20	15	-	-	HYPH
cord-261028-sxux2ujo	20	16	NC	NC	NNP
cord-261028-sxux2ujo	20	17	-	-	HYPH
cord-261028-sxux2ujo	20	18	ND	ND	NNP
cord-261028-sxux2ujo	20	19	license	license	NN
cord-261028-sxux2ujo	20	20	(	(	-LRB-
cord-261028-sxux2ujo	20	21	http://creativecommons.org/licenses/BY-NC-ND/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NN
cord-261028-sxux2ujo	20	22	)	)	-RRB-
cord-261028-sxux2ujo	20	23	.	.	.
cord-261028-sxux2ujo	21	1	sensors	sensor	NNS
cord-261028-sxux2ujo	21	2	of	of	IN
cord-261028-sxux2ujo	21	3	innate	innate	JJ
cord-261028-sxux2ujo	21	4	activation	activation	NN
cord-261028-sxux2ujo	21	5	signals	signal	NNS
cord-261028-sxux2ujo	21	6	from	from	IN
cord-261028-sxux2ujo	21	7	cancer	cancer	NN
cord-261028-sxux2ujo	21	8	that	that	WDT
cord-261028-sxux2ujo	21	9	are	be	VBP
cord-261028-sxux2ujo	21	10	necessary	necessary	JJ
cord-261028-sxux2ujo	21	11	for	for	IN
cord-261028-sxux2ujo	21	12	their	-PRON-	PRP$
cord-261028-sxux2ujo	21	13	activation	activation	NN
cord-261028-sxux2ujo	21	14	and	and	CC
cord-261028-sxux2ujo	21	15	effective	effective	JJ
cord-261028-sxux2ujo	21	16	priming	priming	NN
cord-261028-sxux2ujo	21	17	of	of	IN
cord-261028-sxux2ujo	21	18	cancer	cancer	NN
cord-261028-sxux2ujo	21	19	specific	specific	JJ
cord-261028-sxux2ujo	21	20	T	t	NN
cord-261028-sxux2ujo	21	21	cells	cell	NNS
cord-261028-sxux2ujo	21	22	.	.	.
cord-261028-sxux2ujo	22	1	Here	here	RB
cord-261028-sxux2ujo	22	2	we	-PRON-	PRP
cord-261028-sxux2ujo	22	3	discuss	discuss	VBP
cord-261028-sxux2ujo	22	4	the	the	DT
cord-261028-sxux2ujo	22	5	role	role	NN
cord-261028-sxux2ujo	22	6	of	of	IN
cord-261028-sxux2ujo	22	7	DCs	dc	NNS
cord-261028-sxux2ujo	22	8	in	in	IN
cord-261028-sxux2ujo	22	9	the	the	DT
cord-261028-sxux2ujo	22	10	sensing	sensing	NN
cord-261028-sxux2ujo	22	11	of	of	IN
cord-261028-sxux2ujo	22	12	cancer	cancer	NN
cord-261028-sxux2ujo	22	13	and	and	CC
cord-261028-sxux2ujo	22	14	in	in	IN
cord-261028-sxux2ujo	22	15	priming	prime	VBG
cord-261028-sxux2ujo	22	16	the	the	DT
cord-261028-sxux2ujo	22	17	adaptive	adaptive	JJ
cord-261028-sxux2ujo	22	18	response	response	NN
cord-261028-sxux2ujo	22	19	against	against	IN
cord-261028-sxux2ujo	22	20	tumors	tumor	NNS
cord-261028-sxux2ujo	22	21	.	.	.
cord-261028-sxux2ujo	23	1	Furthermore	furthermore	RB
cord-261028-sxux2ujo	23	2	,	,	,
cord-261028-sxux2ujo	23	3	we	-PRON-	PRP
cord-261028-sxux2ujo	23	4	present	present	VBP
cord-261028-sxux2ujo	23	5	the	the	DT
cord-261028-sxux2ujo	23	6	essential	essential	JJ
cord-261028-sxux2ujo	23	7	role	role	NN
cord-261028-sxux2ujo	23	8	of	of	IN
cord-261028-sxux2ujo	23	9	the	the	DT
cord-261028-sxux2ujo	23	10	Stimulator	Stimulator	NNP
cord-261028-sxux2ujo	23	11	of	of	IN
cord-261028-sxux2ujo	23	12	Interferon	Interferon	NNP
cord-261028-sxux2ujo	23	13	Genes	Genes	NNP
cord-261028-sxux2ujo	23	14	(	(	-LRB-
cord-261028-sxux2ujo	23	15	STING	STING	NNP
cord-261028-sxux2ujo	23	16	)	)	-RRB-
cord-261028-sxux2ujo	23	17	signaling	signal	VBG
cord-261028-sxux2ujo	23	18	pathway	pathway	NN
cord-261028-sxux2ujo	23	19	in	in	IN
cord-261028-sxux2ujo	23	20	producing	produce	VBG
cord-261028-sxux2ujo	23	21	type	type	NN
cord-261028-sxux2ujo	23	22	I	-PRON-	PRP
cord-261028-sxux2ujo	23	23	interferons	interferon	NNS
cord-261028-sxux2ujo	23	24	(	(	-LRB-
cord-261028-sxux2ujo	23	25	IFNs	ifns	NN
cord-261028-sxux2ujo	23	26	)	)	-RRB-
cord-261028-sxux2ujo	23	27	that	that	WDT
cord-261028-sxux2ujo	23	28	are	be	VBP
cord-261028-sxux2ujo	23	29	essential	essential	JJ
cord-261028-sxux2ujo	23	30	in	in	IN
cord-261028-sxux2ujo	23	31	this	this	DT
cord-261028-sxux2ujo	23	32	process	process	NN
cord-261028-sxux2ujo	23	33	.	.	.
cord-261028-sxux2ujo	24	1	Dendritic	dendritic	JJ
cord-261028-sxux2ujo	24	2	cells	cell	NNS
cord-261028-sxux2ujo	24	3	(	(	-LRB-
cord-261028-sxux2ujo	24	4	DCs	DCs	NNP
cord-261028-sxux2ujo	24	5	)	)	-RRB-
cord-261028-sxux2ujo	24	6	are	be	VBP
cord-261028-sxux2ujo	24	7	a	a	DT
cord-261028-sxux2ujo	24	8	heterogeneous	heterogeneous	JJ
cord-261028-sxux2ujo	24	9	population	population	NN
cord-261028-sxux2ujo	24	10	of	of	IN
cord-261028-sxux2ujo	24	11	professional	professional	JJ
cord-261028-sxux2ujo	24	12	antigen	antigen	NN
cord-261028-sxux2ujo	24	13	-	-	HYPH
cord-261028-sxux2ujo	24	14	presenting	present	VBG
cord-261028-sxux2ujo	24	15	cells	cell	NNS
cord-261028-sxux2ujo	24	16	(	(	-LRB-
cord-261028-sxux2ujo	24	17	APCs	apc	NNS
cord-261028-sxux2ujo	24	18	)	)	-RRB-
cord-261028-sxux2ujo	24	19	from	from	IN
cord-261028-sxux2ujo	24	20	hematopoietic	hematopoietic	JJ
cord-261028-sxux2ujo	24	21	origin	origin	NN
cord-261028-sxux2ujo	24	22	that	that	WDT
cord-261028-sxux2ujo	24	23	serve	serve	VBP
cord-261028-sxux2ujo	24	24	as	as	IN
cord-261028-sxux2ujo	24	25	a	a	DT
cord-261028-sxux2ujo	24	26	key	key	JJ
cord-261028-sxux2ujo	24	27	link	link	NN
cord-261028-sxux2ujo	24	28	between	between	IN
cord-261028-sxux2ujo	24	29	the	the	DT
cord-261028-sxux2ujo	24	30	innate	innate	JJ
cord-261028-sxux2ujo	24	31	and	and	CC
cord-261028-sxux2ujo	24	32	adaptive	adaptive	JJ
cord-261028-sxux2ujo	24	33	immune	immune	JJ
cord-261028-sxux2ujo	24	34	systems	system	NNS
cord-261028-sxux2ujo	24	35	,	,	,
cord-261028-sxux2ujo	24	36	and	and	CC
cord-261028-sxux2ujo	24	37	are	be	VBP
cord-261028-sxux2ujo	24	38	the	the	DT
cord-261028-sxux2ujo	24	39	lynchpin	lynchpin	NN
cord-261028-sxux2ujo	24	40	in	in	IN
cord-261028-sxux2ujo	24	41	generating	generate	VBG
cord-261028-sxux2ujo	24	42	anti	anti	JJ
cord-261028-sxux2ujo	24	43	-	-	JJ
cord-261028-sxux2ujo	24	44	tumor	tumor	JJ
cord-261028-sxux2ujo	24	45	immunity	immunity	NN
cord-261028-sxux2ujo	24	46	(	(	-LRB-
cord-261028-sxux2ujo	24	47	Steinman	Steinman	NNP
cord-261028-sxux2ujo	24	48	and	and	CC
cord-261028-sxux2ujo	24	49	Idoyaga	Idoyaga	NNP
cord-261028-sxux2ujo	24	50	,	,	,
cord-261028-sxux2ujo	24	51	2010	2010	CD
cord-261028-sxux2ujo	24	52	)	)	-RRB-
cord-261028-sxux2ujo	24	53	.	.	.
cord-261028-sxux2ujo	25	1	DCs	DCs	NNP
cord-261028-sxux2ujo	25	2	initially	initially	RB
cord-261028-sxux2ujo	25	3	develop	develop	VBP
cord-261028-sxux2ujo	25	4	in	in	IN
cord-261028-sxux2ujo	25	5	the	the	DT
cord-261028-sxux2ujo	25	6	bone	bone	NN
cord-261028-sxux2ujo	25	7	marrow	marrow	NN
cord-261028-sxux2ujo	25	8	from	from	IN
cord-261028-sxux2ujo	25	9	a	a	DT
cord-261028-sxux2ujo	25	10	Flt3	flt3	NN
cord-261028-sxux2ujo	25	11	expressing	express	VBG
cord-261028-sxux2ujo	25	12	common	common	JJ
cord-261028-sxux2ujo	25	13	myeloid	myeloid	NN
cord-261028-sxux2ujo	25	14	precursor	precursor	NN
cord-261028-sxux2ujo	25	15	shared	share	VBN
cord-261028-sxux2ujo	25	16	with	with	IN
cord-261028-sxux2ujo	25	17	monocytes	monocyte	NNS
cord-261028-sxux2ujo	25	18	and	and	CC
cord-261028-sxux2ujo	25	19	macrophages	macrophage	NNS
cord-261028-sxux2ujo	25	20	(	(	-LRB-
cord-261028-sxux2ujo	25	21	macrophage	macrophage	NN
cord-261028-sxux2ujo	25	22	-	-	HYPH
cord-261028-sxux2ujo	25	23	DC	DC	NNP
cord-261028-sxux2ujo	25	24	progenitor	progenitor	NN
cord-261028-sxux2ujo	25	25	,	,	,
cord-261028-sxux2ujo	25	26	MDP	MDP	NNP
cord-261028-sxux2ujo	25	27	)	)	-RRB-
cord-261028-sxux2ujo	25	28	which	which	WDT
cord-261028-sxux2ujo	25	29	gives	give	VBZ
cord-261028-sxux2ujo	25	30	rise	rise	NN
cord-261028-sxux2ujo	25	31	to	to	IN
cord-261028-sxux2ujo	25	32	DC	DC	NNP
cord-261028-sxux2ujo	25	33	-	-	HYPH
cord-261028-sxux2ujo	25	34	restricted	restrict	VBN
cord-261028-sxux2ujo	25	35	progenitors	progenitor	NNS
cord-261028-sxux2ujo	25	36	that	that	WDT
cord-261028-sxux2ujo	25	37	migrate	migrate	VBP
cord-261028-sxux2ujo	25	38	to	to	IN
cord-261028-sxux2ujo	25	39	the	the	DT
cord-261028-sxux2ujo	25	40	lymphoid	lymphoid	JJ
cord-261028-sxux2ujo	25	41	organs	organ	NNS
cord-261028-sxux2ujo	25	42	.	.	.
cord-261028-sxux2ujo	26	1	Development	development	NN
cord-261028-sxux2ujo	26	2	of	of	IN
cord-261028-sxux2ujo	26	3	specific	specific	JJ
cord-261028-sxux2ujo	26	4	subsets	subset	NNS
cord-261028-sxux2ujo	26	5	is	be	VBZ
cord-261028-sxux2ujo	26	6	dictated	dictate	VBN
cord-261028-sxux2ujo	26	7	by	by	IN
cord-261028-sxux2ujo	26	8	transcriptional	transcriptional	JJ
cord-261028-sxux2ujo	26	9	regulatory	regulatory	JJ
cord-261028-sxux2ujo	26	10	programs	program	NNS
cord-261028-sxux2ujo	26	11	,	,	,
cord-261028-sxux2ujo	26	12	sensing	sensing	NN
cord-261028-sxux2ujo	26	13	of	of	IN
cord-261028-sxux2ujo	26	14	growth	growth	NN
cord-261028-sxux2ujo	26	15	factors	factor	NNS
cord-261028-sxux2ujo	26	16	(	(	-LRB-
cord-261028-sxux2ujo	26	17	e.g.	e.g.	RB
cord-261028-sxux2ujo	26	18	GM	GM	NNP
cord-261028-sxux2ujo	26	19	-	-	HYPH
cord-261028-sxux2ujo	26	20	CSF	CSF	NNP
cord-261028-sxux2ujo	26	21	and	and	CC
cord-261028-sxux2ujo	26	22	FLT3L	flt3l	CD
cord-261028-sxux2ujo	26	23	)	)	-RRB-
cord-261028-sxux2ujo	26	24	,	,	,
cord-261028-sxux2ujo	26	25	and	and	CC
cord-261028-sxux2ujo	26	26	cues	cue	NNS
cord-261028-sxux2ujo	26	27	from	from	IN
cord-261028-sxux2ujo	26	28	the	the	DT
cord-261028-sxux2ujo	26	29	local	local	JJ
cord-261028-sxux2ujo	26	30	environment	environment	NN
cord-261028-sxux2ujo	26	31	.	.	.
cord-261028-sxux2ujo	27	1	Consequently	consequently	RB
cord-261028-sxux2ujo	27	2	,	,	,
cord-261028-sxux2ujo	27	3	the	the	DT
cord-261028-sxux2ujo	27	4	various	various	JJ
cord-261028-sxux2ujo	27	5	DC	DC	NNP
cord-261028-sxux2ujo	27	6	subtypes	subtype	NNS
cord-261028-sxux2ujo	27	7	display	display	VBP
cord-261028-sxux2ujo	27	8	distinct	distinct	JJ
cord-261028-sxux2ujo	27	9	transcriptional	transcriptional	JJ
cord-261028-sxux2ujo	27	10	programs	program	NNS
cord-261028-sxux2ujo	27	11	,	,	,
cord-261028-sxux2ujo	27	12	morphology	morphology	NN
cord-261028-sxux2ujo	27	13	,	,	,
cord-261028-sxux2ujo	27	14	phenotype	phenotype	NN
cord-261028-sxux2ujo	27	15	,	,	,
cord-261028-sxux2ujo	27	16	and	and	CC
cord-261028-sxux2ujo	27	17	function	function	VB
cord-261028-sxux2ujo	27	18	in	in	IN
cord-261028-sxux2ujo	27	19	different	different	JJ
cord-261028-sxux2ujo	27	20	tissues	tissue	NNS
cord-261028-sxux2ujo	27	21	under	under	IN
cord-261028-sxux2ujo	27	22	different	different	JJ
cord-261028-sxux2ujo	27	23	conditions	condition	NNS
cord-261028-sxux2ujo	27	24	.	.	.
cord-261028-sxux2ujo	28	1	Here	here	RB
cord-261028-sxux2ujo	28	2	we	-PRON-	PRP
cord-261028-sxux2ujo	28	3	provide	provide	VBP
cord-261028-sxux2ujo	28	4	a	a	DT
cord-261028-sxux2ujo	28	5	brief	brief	JJ
cord-261028-sxux2ujo	28	6	overview	overview	NN
cord-261028-sxux2ujo	28	7	of	of	IN
cord-261028-sxux2ujo	28	8	the	the	DT
cord-261028-sxux2ujo	28	9	three	three	CD
cord-261028-sxux2ujo	28	10	main	main	JJ
cord-261028-sxux2ujo	28	11	DC	DC	NNP
cord-261028-sxux2ujo	28	12	populations	population	NNS
cord-261028-sxux2ujo	28	13	;	;	:
cord-261028-sxux2ujo	28	14	blood	blood	NN
cord-261028-sxux2ujo	28	15	borne	borne	JJ
cord-261028-sxux2ujo	28	16	and	and	CC
cord-261028-sxux2ujo	28	17	lymphoid	lymphoid	JJ
cord-261028-sxux2ujo	28	18	DCs	dc	NNS
cord-261028-sxux2ujo	28	19	,	,	,
cord-261028-sxux2ujo	28	20	tissue	tissue	NN
cord-261028-sxux2ujo	28	21	DCs	DCs	NNP
cord-261028-sxux2ujo	28	22	,	,	,
cord-261028-sxux2ujo	28	23	and	and	CC
cord-261028-sxux2ujo	28	24	monocyte	monocyte	NNP
cord-261028-sxux2ujo	28	25	-	-	HYPH
cord-261028-sxux2ujo	28	26	derived	derive	VBN
cord-261028-sxux2ujo	28	27	DCs	dc	NNS
cord-261028-sxux2ujo	28	28	that	that	WDT
cord-261028-sxux2ujo	28	29	encompass	encompass	VBP
cord-261028-sxux2ujo	28	30	the	the	DT
cord-261028-sxux2ujo	28	31	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	28	32	DC	DC	NNP
cord-261028-sxux2ujo	28	33	populations	population	NNS
cord-261028-sxux2ujo	28	34	involved	involve	VBN
cord-261028-sxux2ujo	28	35	in	in	IN
cord-261028-sxux2ujo	28	36	tumor	tumor	NN
cord-261028-sxux2ujo	28	37	immunity	immunity	NN
cord-261028-sxux2ujo	28	38	.	.	.
cord-261028-sxux2ujo	29	1	In	in	IN
cord-261028-sxux2ujo	29	2	-	-	HYPH
cord-261028-sxux2ujo	29	3	depth	depth	NN
cord-261028-sxux2ujo	29	4	coverage	coverage	NN
cord-261028-sxux2ujo	29	5	of	of	IN
cord-261028-sxux2ujo	29	6	DC	DC	NNP
cord-261028-sxux2ujo	29	7	development	development	NN
cord-261028-sxux2ujo	29	8	,	,	,
cord-261028-sxux2ujo	29	9	lineages	lineage	NNS
cord-261028-sxux2ujo	29	10	and	and	CC
cord-261028-sxux2ujo	29	11	subtypes	subtype	NNS
cord-261028-sxux2ujo	29	12	has	have	VBZ
cord-261028-sxux2ujo	29	13	been	be	VBN
cord-261028-sxux2ujo	29	14	excellently	excellently	RB
cord-261028-sxux2ujo	29	15	reviewed	review	VBN
cord-261028-sxux2ujo	29	16	elsewhere	elsewhere	RB
cord-261028-sxux2ujo	30	1	(	(	-LRB-
cord-261028-sxux2ujo	30	2	Hashimoto	Hashimoto	NNP
cord-261028-sxux2ujo	30	3	et	et	NNP
cord-261028-sxux2ujo	30	4	al	al	NNP
cord-261028-sxux2ujo	30	5	.	.	NNP
cord-261028-sxux2ujo	30	6	,	,	,
cord-261028-sxux2ujo	30	7	2011	2011	CD
cord-261028-sxux2ujo	30	8	;	;	:
cord-261028-sxux2ujo	30	9	del	del	NNP
cord-261028-sxux2ujo	30	10	Rio	Rio	NNP
cord-261028-sxux2ujo	30	11	et	et	FW
cord-261028-sxux2ujo	30	12	al	al	NNP
cord-261028-sxux2ujo	30	13	.	.	NNP
cord-261028-sxux2ujo	30	14	,	,	,
cord-261028-sxux2ujo	30	15	2010	2010	CD
cord-261028-sxux2ujo	31	1	;	;	:
cord-261028-sxux2ujo	31	2	Randolph	Randolph	NNP
cord-261028-sxux2ujo	31	3	et	et	NNP
cord-261028-sxux2ujo	31	4	al	al	NNP
cord-261028-sxux2ujo	31	5	.	.	NNP
cord-261028-sxux2ujo	31	6	,	,	,
cord-261028-sxux2ujo	31	7	2008	2008	CD
cord-261028-sxux2ujo	31	8	;	;	:
cord-261028-sxux2ujo	31	9	Merad	Merad	NNP
cord-261028-sxux2ujo	31	10	et	et	NNP
cord-261028-sxux2ujo	31	11	al	al	NNP
cord-261028-sxux2ujo	31	12	.	.	NNP
cord-261028-sxux2ujo	31	13	,	,	,
cord-261028-sxux2ujo	31	14	2013	2013	CD
cord-261028-sxux2ujo	31	15	;	;	:
cord-261028-sxux2ujo	31	16	Chopin	Chopin	NNP
cord-261028-sxux2ujo	31	17	et	et	NNP
cord-261028-sxux2ujo	31	18	al	al	NNP
cord-261028-sxux2ujo	31	19	.	.	NNP
cord-261028-sxux2ujo	31	20	,	,	,
cord-261028-sxux2ujo	31	21	2012	2012	CD
cord-261028-sxux2ujo	31	22	;	;	.
cord-261028-sxux2ujo	32	1	Satpathy	Satpathy	NNP
cord-261028-sxux2ujo	32	2	et	et	NNP
cord-261028-sxux2ujo	32	3	al	al	NNP
cord-261028-sxux2ujo	32	4	.	.	NNP
cord-261028-sxux2ujo	32	5	,	,	,
cord-261028-sxux2ujo	32	6	2011	2011	CD
cord-261028-sxux2ujo	32	7	;	;	:
cord-261028-sxux2ujo	32	8	Moore	Moore	NNP
cord-261028-sxux2ujo	32	9	et	et	NNP
cord-261028-sxux2ujo	32	10	al	al	NNP
cord-261028-sxux2ujo	32	11	.	.	NNP
cord-261028-sxux2ujo	32	12	,	,	,
cord-261028-sxux2ujo	32	13	2012	2012	CD
cord-261028-sxux2ujo	32	14	;	;	.
cord-261028-sxux2ujo	33	1	Moore	Moore	NNP
cord-261028-sxux2ujo	33	2	and	and	CC
cord-261028-sxux2ujo	33	3	Anderson	Anderson	NNP
cord-261028-sxux2ujo	33	4	,	,	,
cord-261028-sxux2ujo	33	5	2013	2013	CD
cord-261028-sxux2ujo	33	6	;	;	:
cord-261028-sxux2ujo	33	7	Liu	Liu	NNP
cord-261028-sxux2ujo	33	8	and	and	CC
cord-261028-sxux2ujo	33	9	Nussenzweig	Nussenzweig	NNP
cord-261028-sxux2ujo	33	10	,	,	,
cord-261028-sxux2ujo	33	11	2010	2010	CD
cord-261028-sxux2ujo	33	12	)	)	-RRB-
cord-261028-sxux2ujo	33	13	.	.	.
cord-261028-sxux2ujo	34	1	DCs	dc	NNS
cord-261028-sxux2ujo	34	2	are	be	VBP
cord-261028-sxux2ujo	34	3	generally	generally	RB
cord-261028-sxux2ujo	34	4	separated	separate	VBN
cord-261028-sxux2ujo	34	5	into	into	IN
cord-261028-sxux2ujo	34	6	two	two	CD
cord-261028-sxux2ujo	34	7	major	major	JJ
cord-261028-sxux2ujo	34	8	groups	group	NNS
cord-261028-sxux2ujo	34	9	within	within	IN
cord-261028-sxux2ujo	34	10	the	the	DT
cord-261028-sxux2ujo	34	11	blood	blood	NN
cord-261028-sxux2ujo	34	12	and	and	CC
cord-261028-sxux2ujo	34	13	lymphoid	lymphoid	JJ
cord-261028-sxux2ujo	34	14	tissues	tissue	NNS
cord-261028-sxux2ujo	34	15	of	of	IN
cord-261028-sxux2ujo	34	16	mice	mouse	NNS
cord-261028-sxux2ujo	34	17	and	and	CC
cord-261028-sxux2ujo	34	18	humans	human	NNS
cord-261028-sxux2ujo	34	19	;	;	:
cord-261028-sxux2ujo	34	20	plasmacytoid	plasmacytoid	NNP
cord-261028-sxux2ujo	34	21	DCs	DCs	NNP
cord-261028-sxux2ujo	34	22	(	(	-LRB-
cord-261028-sxux2ujo	34	23	pDCs	pDCs	NNP
cord-261028-sxux2ujo	34	24	)	)	-RRB-
cord-261028-sxux2ujo	34	25	and	and	CC
cord-261028-sxux2ujo	34	26	conventional	conventional	JJ
cord-261028-sxux2ujo	34	27	DCs	dc	NNS
cord-261028-sxux2ujo	34	28	(	(	-LRB-
cord-261028-sxux2ujo	34	29	cDCs	cDCs	NNP
cord-261028-sxux2ujo	34	30	)	)	-RRB-
cord-261028-sxux2ujo	34	31	.	.	.
cord-261028-sxux2ujo	35	1	The	the	DT
cord-261028-sxux2ujo	35	2	cDCs	cdc	NNS
cord-261028-sxux2ujo	35	3	are	be	VBP
cord-261028-sxux2ujo	35	4	further	further	RB
cord-261028-sxux2ujo	35	5	divided	divide	VBN
cord-261028-sxux2ujo	35	6	into	into	IN
cord-261028-sxux2ujo	35	7	subsets	subset	NNS
cord-261028-sxux2ujo	35	8	based	base	VBN
cord-261028-sxux2ujo	35	9	on	on	IN
cord-261028-sxux2ujo	35	10	their	-PRON-	PRP$
cord-261028-sxux2ujo	35	11	presumed	presume	VBN
cord-261028-sxux2ujo	35	12	development	development	NN
cord-261028-sxux2ujo	35	13	from	from	IN
cord-261028-sxux2ujo	35	14	myeloid	myeloid	JJ
cord-261028-sxux2ujo	35	15	or	or	CC
cord-261028-sxux2ujo	35	16	lymphoid	lymphoid	JJ
cord-261028-sxux2ujo	35	17	precursors	precursor	NNS
cord-261028-sxux2ujo	35	18	and	and	CC
cord-261028-sxux2ujo	35	19	their	-PRON-	PRP$
cord-261028-sxux2ujo	35	20	expression	expression	NN
cord-261028-sxux2ujo	35	21	levels	level	NNS
cord-261028-sxux2ujo	35	22	of	of	IN
cord-261028-sxux2ujo	35	23	CD8α	CD8α	NNP
cord-261028-sxux2ujo	35	24	,	,	,
cord-261028-sxux2ujo	35	25	CD4	CD4	NNP
cord-261028-sxux2ujo	35	26	and	and	CC
cord-261028-sxux2ujo	35	27	CD11b	CD11b	NNPS
cord-261028-sxux2ujo	35	28	.	.	.
cord-261028-sxux2ujo	36	1	Due	due	IN
cord-261028-sxux2ujo	36	2	to	to	IN
cord-261028-sxux2ujo	36	3	technological	technological	JJ
cord-261028-sxux2ujo	36	4	advancements	advancement	NNS
cord-261028-sxux2ujo	36	5	in	in	IN
cord-261028-sxux2ujo	36	6	omics	omic	NNS
cord-261028-sxux2ujo	36	7	and	and	CC
cord-261028-sxux2ujo	36	8	multi	multi	JJ
cord-261028-sxux2ujo	36	9	-	-	JJ
cord-261028-sxux2ujo	36	10	parameter	parameter	NN
cord-261028-sxux2ujo	36	11	functional	functional	JJ
cord-261028-sxux2ujo	36	12	and	and	CC
cord-261028-sxux2ujo	36	13	phenotypic	phenotypic	JJ
cord-261028-sxux2ujo	36	14	assessments	assessment	NNS
cord-261028-sxux2ujo	36	15	,	,	,
cord-261028-sxux2ujo	36	16	this	this	DT
cord-261028-sxux2ujo	36	17	rudimentary	rudimentary	JJ
cord-261028-sxux2ujo	36	18	division	division	NN
cord-261028-sxux2ujo	36	19	has	have	VBZ
cord-261028-sxux2ujo	36	20	been	be	VBN
cord-261028-sxux2ujo	36	21	shown	show	VBN
cord-261028-sxux2ujo	36	22	to	to	TO
cord-261028-sxux2ujo	36	23	be	be	VB
cord-261028-sxux2ujo	36	24	too	too	RB
cord-261028-sxux2ujo	36	25	limited	limited	JJ
cord-261028-sxux2ujo	36	26	to	to	TO
cord-261028-sxux2ujo	36	27	properly	properly	RB
cord-261028-sxux2ujo	36	28	capture	capture	VB
cord-261028-sxux2ujo	36	29	the	the	DT
cord-261028-sxux2ujo	36	30	true	true	JJ
cord-261028-sxux2ujo	36	31	variety	variety	NN
cord-261028-sxux2ujo	36	32	of	of	IN
cord-261028-sxux2ujo	36	33	DC	DC	NNP
cord-261028-sxux2ujo	36	34	populations	population	NNS
cord-261028-sxux2ujo	36	35	.	.	.
cord-261028-sxux2ujo	37	1	Currently	currently	RB
cord-261028-sxux2ujo	37	2	,	,	,
cord-261028-sxux2ujo	37	3	there	there	EX
cord-261028-sxux2ujo	37	4	is	be	VBZ
cord-261028-sxux2ujo	37	5	a	a	DT
cord-261028-sxux2ujo	37	6	movement	movement	NN
cord-261028-sxux2ujo	37	7	to	to	TO
cord-261028-sxux2ujo	37	8	divide	divide	VB
cord-261028-sxux2ujo	37	9	the	the	DT
cord-261028-sxux2ujo	37	10	various	various	JJ
cord-261028-sxux2ujo	37	11	subtypes	subtype	NNS
cord-261028-sxux2ujo	37	12	of	of	IN
cord-261028-sxux2ujo	37	13	conventional	conventional	JJ
cord-261028-sxux2ujo	37	14	DCs	dc	NNS
cord-261028-sxux2ujo	37	15	into	into	IN
cord-261028-sxux2ujo	37	16	two	two	CD
cord-261028-sxux2ujo	37	17	main	main	JJ
cord-261028-sxux2ujo	37	18	categories	category	NNS
cord-261028-sxux2ujo	37	19	,	,	,
cord-261028-sxux2ujo	37	20	cDC1	cDC1	NNP
cord-261028-sxux2ujo	37	21	and	and	CC
cord-261028-sxux2ujo	37	22	cDC2	cDC2	NNP
cord-261028-sxux2ujo	37	23	,	,	,
cord-261028-sxux2ujo	37	24	based	base	VBN
cord-261028-sxux2ujo	37	25	on	on	IN
cord-261028-sxux2ujo	37	26	a	a	DT
cord-261028-sxux2ujo	37	27	combination	combination	NN
cord-261028-sxux2ujo	37	28	of	of	IN
cord-261028-sxux2ujo	37	29	lineage	lineage	NN
cord-261028-sxux2ujo	37	30	and	and	CC
cord-261028-sxux2ujo	37	31	expression	expression	NN
cord-261028-sxux2ujo	37	32	of	of	IN
cord-261028-sxux2ujo	37	33	transcription	transcription	NN
cord-261028-sxux2ujo	37	34	factors	factor	NNS
cord-261028-sxux2ujo	37	35	and	and	CC
cord-261028-sxux2ujo	37	36	surface	surface	NN
cord-261028-sxux2ujo	37	37	markers	marker	NNS
cord-261028-sxux2ujo	37	38	.	.	.
cord-261028-sxux2ujo	38	1	While	while	IN
cord-261028-sxux2ujo	38	2	this	this	DT
cord-261028-sxux2ujo	38	3	approach	approach	NN
cord-261028-sxux2ujo	38	4	to	to	IN
cord-261028-sxux2ujo	38	5	classification	classification	NN
cord-261028-sxux2ujo	38	6	is	be	VBZ
cord-261028-sxux2ujo	38	7	a	a	DT
cord-261028-sxux2ujo	38	8	significant	significant	JJ
cord-261028-sxux2ujo	38	9	improvement	improvement	NN
cord-261028-sxux2ujo	38	10	,	,	,
cord-261028-sxux2ujo	38	11	it	-PRON-	PRP
cord-261028-sxux2ujo	38	12	has	have	VBZ
cord-261028-sxux2ujo	38	13	been	be	VBN
cord-261028-sxux2ujo	38	14	primarily	primarily	RB
cord-261028-sxux2ujo	38	15	developed	develop	VBN
cord-261028-sxux2ujo	38	16	in	in	IN
cord-261028-sxux2ujo	38	17	mice	mouse	NNS
cord-261028-sxux2ujo	38	18	and	and	CC
cord-261028-sxux2ujo	38	19	does	do	VBZ
cord-261028-sxux2ujo	38	20	not	not	RB
cord-261028-sxux2ujo	38	21	fully	fully	RB
cord-261028-sxux2ujo	38	22	translate	translate	VB
cord-261028-sxux2ujo	38	23	to	to	IN
cord-261028-sxux2ujo	38	24	the	the	DT
cord-261028-sxux2ujo	38	25	human	human	JJ
cord-261028-sxux2ujo	38	26	system	system	NN
cord-261028-sxux2ujo	38	27	.	.	.
cord-261028-sxux2ujo	39	1	However	however	RB
cord-261028-sxux2ujo	39	2	,	,	,
cord-261028-sxux2ujo	39	3	clear	clear	JJ
cord-261028-sxux2ujo	39	4	genomic	genomic	JJ
cord-261028-sxux2ujo	39	5	and	and	CC
cord-261028-sxux2ujo	39	6	phenotypic	phenotypic	JJ
cord-261028-sxux2ujo	39	7	patterns	pattern	NNS
cord-261028-sxux2ujo	39	8	exist	exist	VBP
cord-261028-sxux2ujo	39	9	in	in	IN
cord-261028-sxux2ujo	39	10	both	both	DT
cord-261028-sxux2ujo	39	11	mouse	mouse	NN
cord-261028-sxux2ujo	39	12	and	and	CC
cord-261028-sxux2ujo	39	13	human	human	JJ
cord-261028-sxux2ujo	39	14	DC	DC	NNP
cord-261028-sxux2ujo	39	15	populations	population	NNS
cord-261028-sxux2ujo	39	16	,	,	,
cord-261028-sxux2ujo	39	17	giving	give	VBG
cord-261028-sxux2ujo	39	18	confidence	confidence	NN
cord-261028-sxux2ujo	39	19	in	in	IN
cord-261028-sxux2ujo	39	20	these	these	DT
cord-261028-sxux2ujo	39	21	tools	tool	NNS
cord-261028-sxux2ujo	39	22	for	for	IN
cord-261028-sxux2ujo	39	23	identification	identification	NN
cord-261028-sxux2ujo	39	24	and	and	CC
cord-261028-sxux2ujo	39	25	subdividing	subdividing	NN
cord-261028-sxux2ujo	39	26	of	of	IN
cord-261028-sxux2ujo	39	27	the	the	DT
cord-261028-sxux2ujo	39	28	major	major	JJ
cord-261028-sxux2ujo	39	29	DC	DC	NNP
cord-261028-sxux2ujo	39	30	populations	population	NNS
cord-261028-sxux2ujo	39	31	.	.	.
cord-261028-sxux2ujo	40	1	require	require	VB
cord-261028-sxux2ujo	40	2	transcription	transcription	NN
cord-261028-sxux2ujo	40	3	factors	factor	NNS
cord-261028-sxux2ujo	41	1	IRF8	IRF8	NNP
cord-261028-sxux2ujo	41	2	,	,	,
cord-261028-sxux2ujo	41	3	Id2	Id2	''
cord-261028-sxux2ujo	41	4	and	and	CC
cord-261028-sxux2ujo	41	5	Batf3	Batf3	NNP
cord-261028-sxux2ujo	41	6	for	for	IN
cord-261028-sxux2ujo	41	7	their	-PRON-	PRP$
cord-261028-sxux2ujo	41	8	development	development	NN
cord-261028-sxux2ujo	41	9	.	.	.
cord-261028-sxux2ujo	42	1	They	-PRON-	PRP
cord-261028-sxux2ujo	42	2	generally	generally	RB
cord-261028-sxux2ujo	42	3	express	express	VBP
cord-261028-sxux2ujo	42	4	mRNA	mrna	NN
cord-261028-sxux2ujo	42	5	for	for	IN
cord-261028-sxux2ujo	42	6	most	most	JJS
cord-261028-sxux2ujo	42	7	Toll	toll	NN
cord-261028-sxux2ujo	42	8	Like	like	IN
cord-261028-sxux2ujo	42	9	Receptors	receptor	NNS
cord-261028-sxux2ujo	42	10	(	(	-LRB-
cord-261028-sxux2ujo	42	11	TLRs	TLRs	NNP
cord-261028-sxux2ujo	42	12	)	)	-RRB-
cord-261028-sxux2ujo	42	13	except	except	IN
cord-261028-sxux2ujo	42	14	TLR5	TLR5	NNP
cord-261028-sxux2ujo	42	15	and	and	CC
cord-261028-sxux2ujo	42	16	TLR7	TLR7	NNP
cord-261028-sxux2ujo	42	17	and	and	CC
cord-261028-sxux2ujo	42	18	are	be	VBP
cord-261028-sxux2ujo	42	19	characterized	characterize	VBN
cord-261028-sxux2ujo	42	20	by	by	IN
cord-261028-sxux2ujo	42	21	high	high	JJ
cord-261028-sxux2ujo	42	22	TLR3	tlr3	CD
cord-261028-sxux2ujo	42	23	expression	expression	NN
cord-261028-sxux2ujo	42	24	(	(	-LRB-
cord-261028-sxux2ujo	42	25	Edwards	Edwards	NNP
cord-261028-sxux2ujo	42	26	et	et	NNP
cord-261028-sxux2ujo	42	27	al	al	NNP
cord-261028-sxux2ujo	42	28	.	.	NNP
cord-261028-sxux2ujo	42	29	,	,	,
cord-261028-sxux2ujo	42	30	2003	2003	CD
cord-261028-sxux2ujo	42	31	)	)	-RRB-
cord-261028-sxux2ujo	42	32	.	.	.
cord-261028-sxux2ujo	43	1	Human	Human	NNP
cord-261028-sxux2ujo	43	2	cDC1	cDC1	NNP
cord-261028-sxux2ujo	43	3	also	also	RB
cord-261028-sxux2ujo	43	4	express	express	VB
cord-261028-sxux2ujo	43	5	CD11c	CD11c	NNP
cord-261028-sxux2ujo	43	6	,	,	,
cord-261028-sxux2ujo	43	7	HLA	HLA	NNP
cord-261028-sxux2ujo	43	8	-	-	HYPH
cord-261028-sxux2ujo	43	9	DR	DR	NNP
cord-261028-sxux2ujo	43	10	,	,	,
cord-261028-sxux2ujo	44	1	XCR1	XCR1	NNP
cord-261028-sxux2ujo	44	2	,	,	,
cord-261028-sxux2ujo	44	3	CD141	CD141	NNP
cord-261028-sxux2ujo	44	4	,	,	,
cord-261028-sxux2ujo	44	5	Clec9a	Clec9a	NNP
cord-261028-sxux2ujo	44	6	,	,	,
cord-261028-sxux2ujo	44	7	DEC-205	DEC-205	NNP
cord-261028-sxux2ujo	44	8	and	and	CC
cord-261028-sxux2ujo	44	9	TLR3	TLR3	NNP
cord-261028-sxux2ujo	44	10	,	,	,
cord-261028-sxux2ujo	44	11	and	and	CC
cord-261028-sxux2ujo	44	12	Batf3	Batf3	NNP
cord-261028-sxux2ujo	44	13	has	have	VBZ
cord-261028-sxux2ujo	44	14	been	be	VBN
cord-261028-sxux2ujo	44	15	implied	imply	VBN
cord-261028-sxux2ujo	44	16	in	in	IN
cord-261028-sxux2ujo	44	17	human	human	JJ
cord-261028-sxux2ujo	44	18	cDC1	cdc1	NN
cord-261028-sxux2ujo	44	19	development	development	NN
cord-261028-sxux2ujo	44	20	(	(	-LRB-
cord-261028-sxux2ujo	44	21	Poulin	Poulin	NNP
cord-261028-sxux2ujo	44	22	et	et	NNP
cord-261028-sxux2ujo	44	23	al	al	NNP
cord-261028-sxux2ujo	44	24	.	.	NNP
cord-261028-sxux2ujo	44	25	,	,	,
cord-261028-sxux2ujo	44	26	2010	2010	CD
cord-261028-sxux2ujo	44	27	;	;	.
cord-261028-sxux2ujo	45	1	Poulin	Poulin	NNP
cord-261028-sxux2ujo	45	2	et	et	NNP
cord-261028-sxux2ujo	45	3	al	al	NNP
cord-261028-sxux2ujo	45	4	.	.	NNP
cord-261028-sxux2ujo	45	5	,	,	,
cord-261028-sxux2ujo	45	6	2012	2012	CD
cord-261028-sxux2ujo	45	7	)	)	-RRB-
cord-261028-sxux2ujo	45	8	,	,	,
cord-261028-sxux2ujo	45	9	while	while	IN
cord-261028-sxux2ujo	45	10	IRF8	IRF8	NNP
cord-261028-sxux2ujo	45	11	might	may	MD
cord-261028-sxux2ujo	45	12	affect	affect	VB
cord-261028-sxux2ujo	45	13	both	both	CC
cord-261028-sxux2ujo	45	14	cDC1	cDC1	NNP
cord-261028-sxux2ujo	45	15	and	and	CC
cord-261028-sxux2ujo	45	16	cDC2	cDC2	NNP
cord-261028-sxux2ujo	45	17	development	development	NN
cord-261028-sxux2ujo	46	1	(	(	-LRB-
cord-261028-sxux2ujo	46	2	Hambleton	Hambleton	NNP
cord-261028-sxux2ujo	46	3	et	et	NNP
cord-261028-sxux2ujo	46	4	al	al	NNP
cord-261028-sxux2ujo	46	5	.	.	NNP
cord-261028-sxux2ujo	46	6	,	,	,
cord-261028-sxux2ujo	46	7	2011	2011	CD
cord-261028-sxux2ujo	47	1	;	;	:
cord-261028-sxux2ujo	47	2	Salem	Salem	NNP
cord-261028-sxux2ujo	47	3	et	et	NNP
cord-261028-sxux2ujo	47	4	al	al	NNP
cord-261028-sxux2ujo	47	5	.	.	.
cord-261028-sxux2ujo	48	1	,	,	,
cord-261028-sxux2ujo	48	2	2014	2014	CD
cord-261028-sxux2ujo	48	3	)	)	-RRB-
cord-261028-sxux2ujo	48	4	.	.	.
cord-261028-sxux2ujo	49	1	Like	like	IN
cord-261028-sxux2ujo	49	2	mouse	mouse	NN
cord-261028-sxux2ujo	49	3	cDC1	cDC1	NNP
cord-261028-sxux2ujo	49	4	,	,	,
cord-261028-sxux2ujo	49	5	human	human	JJ
cord-261028-sxux2ujo	49	6	cDC1	cDC1	NNP
cord-261028-sxux2ujo	49	7	have	have	VBP
cord-261028-sxux2ujo	49	8	the	the	DT
cord-261028-sxux2ujo	49	9	greatest	great	JJS
cord-261028-sxux2ujo	49	10	capacity	capacity	NN
cord-261028-sxux2ujo	49	11	for	for	IN
cord-261028-sxux2ujo	49	12	cross	cross	NN
cord-261028-sxux2ujo	49	13	-	-	NN
cord-261028-sxux2ujo	49	14	presentation	presentation	NN
cord-261028-sxux2ujo	49	15	within	within	IN
cord-261028-sxux2ujo	49	16	the	the	DT
cord-261028-sxux2ujo	49	17	human	human	JJ
cord-261028-sxux2ujo	49	18	DC	DC	NNP
cord-261028-sxux2ujo	49	19	populations	population	NNS
cord-261028-sxux2ujo	49	20	(	(	-LRB-
cord-261028-sxux2ujo	49	21	Poulin	Poulin	NNP
cord-261028-sxux2ujo	49	22	et	et	NNP
cord-261028-sxux2ujo	49	23	al	al	NNP
cord-261028-sxux2ujo	49	24	.	.	NNP
cord-261028-sxux2ujo	49	25	,	,	,
cord-261028-sxux2ujo	49	26	2010	2010	CD
cord-261028-sxux2ujo	49	27	;	;	:
cord-261028-sxux2ujo	49	28	Crozat	Crozat	NNP
cord-261028-sxux2ujo	49	29	et	et	NNP
cord-261028-sxux2ujo	49	30	al	al	NNP
cord-261028-sxux2ujo	49	31	.	.	NNP
cord-261028-sxux2ujo	49	32	,	,	,
cord-261028-sxux2ujo	49	33	2010	2010	CD
cord-261028-sxux2ujo	49	34	;	;	.
cord-261028-sxux2ujo	50	1	Jongbloed	Jongbloed	NNP
cord-261028-sxux2ujo	50	2	et	et	NNP
cord-261028-sxux2ujo	50	3	al	al	NNP
cord-261028-sxux2ujo	50	4	.	.	NNP
cord-261028-sxux2ujo	50	5	,	,	,
cord-261028-sxux2ujo	50	6	2010	2010	CD
cord-261028-sxux2ujo	50	7	)	)	-RRB-
cord-261028-sxux2ujo	50	8	.	.	.
cord-261028-sxux2ujo	51	1	In	in	IN
cord-261028-sxux2ujo	51	2	contrast	contrast	NN
cord-261028-sxux2ujo	51	3	to	to	IN
cord-261028-sxux2ujo	51	4	the	the	DT
cord-261028-sxux2ujo	51	5	cDC1	cDC1	NNP
cord-261028-sxux2ujo	51	6	population	population	NN
cord-261028-sxux2ujo	51	7	,	,	,
cord-261028-sxux2ujo	51	8	mouse	mouse	NN
cord-261028-sxux2ujo	51	9	and	and	CC
cord-261028-sxux2ujo	51	10	human	human	NN
cord-261028-sxux2ujo	51	11	cDC2	cDC2	NNP
cord-261028-sxux2ujo	51	12	strongly	strongly	RB
cord-261028-sxux2ujo	51	13	promote	promote	VBP
cord-261028-sxux2ujo	51	14	CD4	CD4	NNP
cord-261028-sxux2ujo	51	15	+	+	CC
cord-261028-sxux2ujo	51	16	T	t	NN
cord-261028-sxux2ujo	51	17	cell	cell	NN
cord-261028-sxux2ujo	51	18	responses	response	NNS
cord-261028-sxux2ujo	51	19	and	and	CC
cord-261028-sxux2ujo	51	20	have	have	VBP
cord-261028-sxux2ujo	51	21	relatively	relatively	RB
cord-261028-sxux2ujo	51	22	poor	poor	JJ
cord-261028-sxux2ujo	51	23	capacity	capacity	NN
cord-261028-sxux2ujo	51	24	to	to	TO
cord-261028-sxux2ujo	51	25	cross	cross	VB
cord-261028-sxux2ujo	51	26	-	-	JJ
cord-261028-sxux2ujo	51	27	present	present	JJ
cord-261028-sxux2ujo	51	28	cell	cell	NN
cord-261028-sxux2ujo	51	29	-	-	HYPH
cord-261028-sxux2ujo	51	30	associated	associate	VBN
cord-261028-sxux2ujo	51	31	antigens	antigen	NNS
cord-261028-sxux2ujo	51	32	to	to	IN
cord-261028-sxux2ujo	51	33	CD8	CD8	NNP
cord-261028-sxux2ujo	51	34	+	+	CC
cord-261028-sxux2ujo	51	35	T	T	NNP
cord-261028-sxux2ujo	51	36	cells	cell	NNS
cord-261028-sxux2ujo	51	37	.	.	.
cord-261028-sxux2ujo	52	1	Mouse	mouse	NN
cord-261028-sxux2ujo	52	2	and	and	CC
cord-261028-sxux2ujo	52	3	human	human	NN
cord-261028-sxux2ujo	52	4	cDC2	cDC2	NNP
cord-261028-sxux2ujo	52	5	express	express	VBP
cord-261028-sxux2ujo	52	6	several	several	JJ
cord-261028-sxux2ujo	52	7	overlapping	overlap	VBG
cord-261028-sxux2ujo	52	8	markers	marker	NNS
cord-261028-sxux2ujo	52	9	,	,	,
cord-261028-sxux2ujo	52	10	including	include	VBG
cord-261028-sxux2ujo	52	11	CD11c	CD11c	NNP
cord-261028-sxux2ujo	52	12	,	,	,
cord-261028-sxux2ujo	52	13	MHCII	MHCII	NNP
cord-261028-sxux2ujo	52	14	,	,	,
cord-261028-sxux2ujo	52	15	CD11b	CD11b	NNPS
cord-261028-sxux2ujo	52	16	and	and	CC
cord-261028-sxux2ujo	52	17	CD172a	CD172a	NNP
cord-261028-sxux2ujo	53	1	(	(	-LRB-
cord-261028-sxux2ujo	53	2	Signal	Signal	NNP
cord-261028-sxux2ujo	53	3	regulatory	regulatory	JJ
cord-261028-sxux2ujo	53	4	protein	protein	NN
cord-261028-sxux2ujo	53	5	Sirpa	Sirpa	NNP
cord-261028-sxux2ujo	53	6	)	)	-RRB-
cord-261028-sxux2ujo	53	7	.	.	.
cord-261028-sxux2ujo	54	1	Mouse	Mouse	NNP
cord-261028-sxux2ujo	54	2	cDC2	cDC2	NNP
cord-261028-sxux2ujo	54	3	often	often	RB
cord-261028-sxux2ujo	54	4	express	express	VBP
cord-261028-sxux2ujo	54	5	CD4	CD4	NNP
cord-261028-sxux2ujo	54	6	while	while	IN
cord-261028-sxux2ujo	54	7	human	human	JJ
cord-261028-sxux2ujo	54	8	cDC2	cDC2	NNP
cord-261028-sxux2ujo	54	9	are	be	VBP
cord-261028-sxux2ujo	54	10	further	further	RB
cord-261028-sxux2ujo	54	11	identified	identify	VBN
cord-261028-sxux2ujo	54	12	by	by	IN
cord-261028-sxux2ujo	54	13	CD1c	CD1c	NNP
cord-261028-sxux2ujo	54	14	/	/	SYM
cord-261028-sxux2ujo	54	15	BDCA1	bdca1	NN
cord-261028-sxux2ujo	54	16	expression	expression	NN
cord-261028-sxux2ujo	54	17	.	.	.
cord-261028-sxux2ujo	55	1	Mouse	Mouse	NNP
cord-261028-sxux2ujo	55	2	cDC2	cDC2	NNP
cord-261028-sxux2ujo	55	3	have	have	VBP
cord-261028-sxux2ujo	55	4	been	be	VBN
cord-261028-sxux2ujo	55	5	shown	show	VBN
cord-261028-sxux2ujo	55	6	to	to	TO
cord-261028-sxux2ujo	55	7	require	require	VB
cord-261028-sxux2ujo	55	8	IRF4	IRF4	NNP
cord-261028-sxux2ujo	55	9	,	,	,
cord-261028-sxux2ujo	55	10	Eb2	eb2	NN
cord-261028-sxux2ujo	55	11	,	,	,
cord-261028-sxux2ujo	55	12	RelB	relb	NN
cord-261028-sxux2ujo	55	13	and	and	CC
cord-261028-sxux2ujo	55	14	Notch2	Notch2	NNP
cord-261028-sxux2ujo	56	1	for	for	IN
cord-261028-sxux2ujo	56	2	their	-PRON-	PRP$
cord-261028-sxux2ujo	56	3	development	development	NN
cord-261028-sxux2ujo	56	4	,	,	,
cord-261028-sxux2ujo	56	5	the	the	DT
cord-261028-sxux2ujo	56	6	role	role	NN
cord-261028-sxux2ujo	56	7	for	for	IN
cord-261028-sxux2ujo	56	8	these	these	DT
cord-261028-sxux2ujo	56	9	factors	factor	NNS
cord-261028-sxux2ujo	56	10	in	in	IN
cord-261028-sxux2ujo	56	11	human	human	JJ
cord-261028-sxux2ujo	56	12	cDC2	cDC2	NNP
cord-261028-sxux2ujo	56	13	development	development	NN
cord-261028-sxux2ujo	56	14	is	be	VBZ
cord-261028-sxux2ujo	56	15	not	not	RB
cord-261028-sxux2ujo	56	16	known	know	VBN
cord-261028-sxux2ujo	56	17	.	.	.
cord-261028-sxux2ujo	57	1	DCs	DCs	NNP
cord-261028-sxux2ujo	57	2	-	-	HYPH
cord-261028-sxux2ujo	57	3	pDCs	pDCs	NNP
cord-261028-sxux2ujo	57	4	are	be	VBP
cord-261028-sxux2ujo	57	5	factories	factory	NNS
cord-261028-sxux2ujo	57	6	for	for	IN
cord-261028-sxux2ujo	57	7	type	type	NN
cord-261028-sxux2ujo	57	8	I	-PRON-	PRP
cord-261028-sxux2ujo	57	9	IFN	IFN	NNP
cord-261028-sxux2ujo	57	10	,	,	,
cord-261028-sxux2ujo	57	11	playing	play	VBG
cord-261028-sxux2ujo	57	12	an	an	DT
cord-261028-sxux2ujo	57	13	important	important	JJ
cord-261028-sxux2ujo	57	14	role	role	NN
cord-261028-sxux2ujo	57	15	in	in	IN
cord-261028-sxux2ujo	57	16	the	the	DT
cord-261028-sxux2ujo	57	17	immune	immune	JJ
cord-261028-sxux2ujo	57	18	response	response	NN
cord-261028-sxux2ujo	57	19	to	to	IN
cord-261028-sxux2ujo	57	20	infection	infection	NN
cord-261028-sxux2ujo	57	21	due	due	IN
cord-261028-sxux2ujo	57	22	to	to	IN
cord-261028-sxux2ujo	57	23	their	-PRON-	PRP$
cord-261028-sxux2ujo	57	24	capacity	capacity	NN
cord-261028-sxux2ujo	57	25	to	to	TO
cord-261028-sxux2ujo	57	26	produce	produce	VB
cord-261028-sxux2ujo	57	27	large	large	JJ
cord-261028-sxux2ujo	57	28	amounts	amount	NNS
cord-261028-sxux2ujo	57	29	of	of	IN
cord-261028-sxux2ujo	57	30	type	type	NN
cord-261028-sxux2ujo	58	1	I	-PRON-	PRP
cord-261028-sxux2ujo	58	2	IFN	IFN	NNP
cord-261028-sxux2ujo	58	3	upon	upon	IN
cord-261028-sxux2ujo	58	4	engagement	engagement	NN
cord-261028-sxux2ujo	58	5	of	of	IN
cord-261028-sxux2ujo	58	6	TLR7	TLR7	NNP
cord-261028-sxux2ujo	58	7	and	and	CC
cord-261028-sxux2ujo	58	8	TLR9	TLR9	NNP
cord-261028-sxux2ujo	58	9	.	.	.
cord-261028-sxux2ujo	59	1	Mouse	Mouse	NNP
cord-261028-sxux2ujo	59	2	pDCs	pdc	MD
cord-261028-sxux2ujo	59	3	express	express	VBP
cord-261028-sxux2ujo	59	4	relatively	relatively	RB
cord-261028-sxux2ujo	59	5	low	low	JJ
cord-261028-sxux2ujo	59	6	levels	level	NNS
cord-261028-sxux2ujo	59	7	of	of	IN
cord-261028-sxux2ujo	59	8	CD11c	CD11c	NNP
cord-261028-sxux2ujo	59	9	and	and	CC
cord-261028-sxux2ujo	59	10	MHCII	MHCII	NNP
cord-261028-sxux2ujo	59	11	and	and	CC
cord-261028-sxux2ujo	59	12	high	high	JJ
cord-261028-sxux2ujo	59	13	levels	level	NNS
cord-261028-sxux2ujo	59	14	of	of	IN
cord-261028-sxux2ujo	59	15	PDCA1	PDCA1	NNS
cord-261028-sxux2ujo	59	16	(	(	-LRB-
cord-261028-sxux2ujo	59	17	CD317	CD317	NNP
cord-261028-sxux2ujo	59	18	)	)	-RRB-
cord-261028-sxux2ujo	59	19	,	,	,
cord-261028-sxux2ujo	59	20	B220	b220	RB
cord-261028-sxux2ujo	59	21	,	,	,
cord-261028-sxux2ujo	59	22	CD123	CD123	NNP
cord-261028-sxux2ujo	59	23	,	,	,
cord-261028-sxux2ujo	59	24	and	and	CC
cord-261028-sxux2ujo	60	1	SiglecH.	SiglecH.	NNP
cord-261028-sxux2ujo	60	2	Human	Human	NNP
cord-261028-sxux2ujo	60	3	pDC	pDC	NNP
cord-261028-sxux2ujo	60	4	also	also	RB
cord-261028-sxux2ujo	60	5	have	have	VBP
cord-261028-sxux2ujo	60	6	reduced	reduce	VBN
cord-261028-sxux2ujo	60	7	CD11c	CD11c	NNP
cord-261028-sxux2ujo	60	8	and	and	CC
cord-261028-sxux2ujo	60	9	HLA	HLA	NNP
cord-261028-sxux2ujo	60	10	-	-	HYPH
cord-261028-sxux2ujo	60	11	DR	DR	NNP
cord-261028-sxux2ujo	60	12	levels	level	NNS
cord-261028-sxux2ujo	60	13	and	and	CC
cord-261028-sxux2ujo	60	14	co	co	JJ
cord-261028-sxux2ujo	60	15	-	-	JJ
cord-261028-sxux2ujo	60	16	express	express	JJ
cord-261028-sxux2ujo	60	17	BDCA2	BDCA2	NNP
cord-261028-sxux2ujo	60	18	(	(	-LRB-
cord-261028-sxux2ujo	60	19	CD303	CD303	NNP
cord-261028-sxux2ujo	60	20	)	)	-RRB-
cord-261028-sxux2ujo	60	21	,	,	,
cord-261028-sxux2ujo	60	22	BDCA4	bdca4	CC
cord-261028-sxux2ujo	61	1	(	(	-LRB-
cord-261028-sxux2ujo	61	2	CD304	cd304	NN
cord-261028-sxux2ujo	61	3	)	)	-RRB-
cord-261028-sxux2ujo	61	4	,	,	.
cord-261028-sxux2ujo	62	1	and	and	CC
cord-261028-sxux2ujo	62	2	CD123	CD123	NNP
cord-261028-sxux2ujo	62	3	.	.	.
cord-261028-sxux2ujo	63	1	Both	both	DT
cord-261028-sxux2ujo	63	2	human	human	NN
cord-261028-sxux2ujo	63	3	and	and	CC
cord-261028-sxux2ujo	63	4	mouse	mouse	NNP
cord-261028-sxux2ujo	63	5	pDC	pDC	NNP
cord-261028-sxux2ujo	63	6	development	development	NN
cord-261028-sxux2ujo	63	7	requires	require	VBZ
cord-261028-sxux2ujo	63	8	the	the	DT
cord-261028-sxux2ujo	63	9	transcription	transcription	NN
cord-261028-sxux2ujo	63	10	factor	factor	NN
cord-261028-sxux2ujo	63	11	E2	E2	NNP
cord-261028-sxux2ujo	63	12	-	-	HYPH
cord-261028-sxux2ujo	63	13	2	2	NNP
cord-261028-sxux2ujo	63	14	and	and	CC
cord-261028-sxux2ujo	63	15	its	-PRON-	PRP$
cord-261028-sxux2ujo	63	16	target	target	NN
cord-261028-sxux2ujo	63	17	gene	gene	NN
cord-261028-sxux2ujo	63	18	,	,	,
cord-261028-sxux2ujo	63	19	Spi	Spi	NNP
cord-261028-sxux2ujo	63	20	-	-	HYPH
cord-261028-sxux2ujo	63	21	B	B	NNP
cord-261028-sxux2ujo	63	22	(	(	-LRB-
cord-261028-sxux2ujo	63	23	Sasaki	Sasaki	NNP
cord-261028-sxux2ujo	63	24	et	et	NNP
cord-261028-sxux2ujo	63	25	al	al	NNP
cord-261028-sxux2ujo	63	26	.	.	NNP
cord-261028-sxux2ujo	63	27	,	,	,
cord-261028-sxux2ujo	63	28	2012	2012	CD
cord-261028-sxux2ujo	63	29	;	;	:
cord-261028-sxux2ujo	63	30	Schotte	Schotte	NNP
cord-261028-sxux2ujo	63	31	et	et	FW
cord-261028-sxux2ujo	63	32	al	al	NNP
cord-261028-sxux2ujo	63	33	.	.	NNP
cord-261028-sxux2ujo	63	34	,	,	,
cord-261028-sxux2ujo	63	35	2004	2004	CD
cord-261028-sxux2ujo	63	36	;	;	:
cord-261028-sxux2ujo	64	1	Cisse	Cisse	NNP
cord-261028-sxux2ujo	64	2	et	et	NNP
cord-261028-sxux2ujo	64	3	al	al	NNP
cord-261028-sxux2ujo	64	4	.	.	.
cord-261028-sxux2ujo	65	1	,	,	,
cord-261028-sxux2ujo	65	2	2008	2008	CD
cord-261028-sxux2ujo	65	3	;	;	:
cord-261028-sxux2ujo	65	4	Reizis	Reizis	NNP
cord-261028-sxux2ujo	65	5	,	,	,
cord-261028-sxux2ujo	65	6	2010	2010	CD
cord-261028-sxux2ujo	65	7	)	)	-RRB-
cord-261028-sxux2ujo	65	8	.	.	.
cord-261028-sxux2ujo	66	1	Although	although	IN
cord-261028-sxux2ujo	66	2	functionally	functionally	RB
cord-261028-sxux2ujo	66	3	relatively	relatively	RB
cord-261028-sxux2ujo	66	4	similar	similar	JJ
cord-261028-sxux2ujo	66	5	,	,	,
cord-261028-sxux2ujo	66	6	human	human	JJ
cord-261028-sxux2ujo	66	7	pDCs	pdc	NNS
cord-261028-sxux2ujo	66	8	are	be	VBP
cord-261028-sxux2ujo	66	9	able	able	JJ
cord-261028-sxux2ujo	66	10	to	to	TO
cord-261028-sxux2ujo	66	11	cross	cross	VB
cord-261028-sxux2ujo	66	12	-	-	JJ
cord-261028-sxux2ujo	66	13	present	present	JJ
cord-261028-sxux2ujo	66	14	cell	cell	NN
cord-261028-sxux2ujo	66	15	-	-	HYPH
cord-261028-sxux2ujo	66	16	associated	associate	VBN
cord-261028-sxux2ujo	66	17	antigens	antigen	NNS
cord-261028-sxux2ujo	66	18	in	in	IN
cord-261028-sxux2ujo	66	19	contrast	contrast	NN
cord-261028-sxux2ujo	66	20	to	to	IN
cord-261028-sxux2ujo	66	21	mouse	mouse	NNP
cord-261028-sxux2ujo	66	22	pDCs	pDCs	NNP
cord-261028-sxux2ujo	66	23	,	,	,
cord-261028-sxux2ujo	66	24	which	which	WDT
cord-261028-sxux2ujo	66	25	show	show	VBP
cord-261028-sxux2ujo	66	26	very	very	RB
cord-261028-sxux2ujo	66	27	poor	poor	JJ
cord-261028-sxux2ujo	66	28	capacity	capacity	NN
cord-261028-sxux2ujo	66	29	to	to	TO
cord-261028-sxux2ujo	66	30	do	do	VB
cord-261028-sxux2ujo	66	31	so	so	RB
cord-261028-sxux2ujo	67	1	(	(	-LRB-
cord-261028-sxux2ujo	67	2	Hoeffel	Hoeffel	NNP
cord-261028-sxux2ujo	67	3	et	et	NNP
cord-261028-sxux2ujo	67	4	al	al	NNP
cord-261028-sxux2ujo	67	5	.	.	NNP
cord-261028-sxux2ujo	67	6	,	,	,
cord-261028-sxux2ujo	67	7	2007	2007	CD
cord-261028-sxux2ujo	67	8	;	;	.
cord-261028-sxux2ujo	68	1	Villadangos	Villadangos	NNP
cord-261028-sxux2ujo	68	2	and	and	CC
cord-261028-sxux2ujo	68	3	Young	Young	NNP
cord-261028-sxux2ujo	68	4	,	,	,
cord-261028-sxux2ujo	68	5	2008	2008	CD
cord-261028-sxux2ujo	68	6	)	)	-RRB-
cord-261028-sxux2ujo	68	7	.	.	.
cord-261028-sxux2ujo	69	1	A	a	DT
cord-261028-sxux2ujo	69	2	large	large	JJ
cord-261028-sxux2ujo	69	3	percentage	percentage	NN
cord-261028-sxux2ujo	69	4	of	of	IN
cord-261028-sxux2ujo	69	5	cDCs	cdcs	NN
cord-261028-sxux2ujo	69	6	reside	reside	VB
cord-261028-sxux2ujo	69	7	in	in	IN
cord-261028-sxux2ujo	69	8	peripheral	peripheral	JJ
cord-261028-sxux2ujo	69	9	tissues	tissue	NNS
cord-261028-sxux2ujo	69	10	and	and	CC
cord-261028-sxux2ujo	69	11	non	non	JJ
cord-261028-sxux2ujo	69	12	-	-	JJ
cord-261028-sxux2ujo	69	13	lymphoid	lymphoid	JJ
cord-261028-sxux2ujo	69	14	organs	organ	NNS
cord-261028-sxux2ujo	69	15	where	where	WRB
cord-261028-sxux2ujo	69	16	they	-PRON-	PRP
cord-261028-sxux2ujo	69	17	help	help	VBP
cord-261028-sxux2ujo	69	18	maintain	maintain	VB
cord-261028-sxux2ujo	69	19	tissue	tissue	NN
cord-261028-sxux2ujo	69	20	homeostasis	homeostasis	NN
cord-261028-sxux2ujo	69	21	,	,	,
cord-261028-sxux2ujo	69	22	promote	promote	VB
cord-261028-sxux2ujo	69	23	immune	immune	JJ
cord-261028-sxux2ujo	69	24	tolerance	tolerance	NN
cord-261028-sxux2ujo	69	25	,	,	,
cord-261028-sxux2ujo	69	26	and	and	CC
cord-261028-sxux2ujo	69	27	serve	serve	VB
cord-261028-sxux2ujo	69	28	as	as	IN
cord-261028-sxux2ujo	69	29	first	first	JJ
cord-261028-sxux2ujo	69	30	responders	responder	NNS
cord-261028-sxux2ujo	69	31	to	to	IN
cord-261028-sxux2ujo	69	32	infectious	infectious	JJ
cord-261028-sxux2ujo	69	33	and	and	CC
cord-261028-sxux2ujo	69	34	neo	neo	JJ
cord-261028-sxux2ujo	69	35	-	-	JJ
cord-261028-sxux2ujo	69	36	plastic	plastic	JJ
cord-261028-sxux2ujo	69	37	insults	insult	NNS
cord-261028-sxux2ujo	69	38	.	.	.
cord-261028-sxux2ujo	70	1	While	while	IN
cord-261028-sxux2ujo	70	2	these	these	DT
cord-261028-sxux2ujo	70	3	cells	cell	NNS
cord-261028-sxux2ujo	70	4	are	be	VBP
cord-261028-sxux2ujo	70	5	generally	generally	RB
cord-261028-sxux2ujo	70	6	less	less	RBR
cord-261028-sxux2ujo	70	7	well	well	RB
cord-261028-sxux2ujo	70	8	characterized	characterized	JJ
cord-261028-sxux2ujo	70	9	than	than	IN
cord-261028-sxux2ujo	70	10	their	-PRON-	PRP$
cord-261028-sxux2ujo	70	11	blood	blood	NN
cord-261028-sxux2ujo	70	12	and	and	CC
cord-261028-sxux2ujo	70	13	lymphoid	lymphoid	NN
cord-261028-sxux2ujo	70	14	associated	associate	VBN
cord-261028-sxux2ujo	70	15	counterparts	counterpart	NNS
cord-261028-sxux2ujo	70	16	,	,	,
cord-261028-sxux2ujo	70	17	they	-PRON-	PRP
cord-261028-sxux2ujo	70	18	play	play	VBP
cord-261028-sxux2ujo	70	19	an	an	DT
cord-261028-sxux2ujo	70	20	important	important	JJ
cord-261028-sxux2ujo	70	21	role	role	NN
cord-261028-sxux2ujo	70	22	in	in	IN
cord-261028-sxux2ujo	70	23	antitumor	antitumor	JJ
cord-261028-sxux2ujo	70	24	responses	response	NNS
cord-261028-sxux2ujo	70	25	as	as	IN
cord-261028-sxux2ujo	70	26	they	-PRON-	PRP
cord-261028-sxux2ujo	70	27	represent	represent	VBP
cord-261028-sxux2ujo	70	28	the	the	DT
cord-261028-sxux2ujo	70	29	first	first	JJ
cord-261028-sxux2ujo	70	30	DC	DC	NNP
cord-261028-sxux2ujo	70	31	populations	population	NNS
cord-261028-sxux2ujo	70	32	present	present	JJ
cord-261028-sxux2ujo	70	33	on	on	IN
cord-261028-sxux2ujo	70	34	site	site	NN
cord-261028-sxux2ujo	70	35	in	in	IN
cord-261028-sxux2ujo	70	36	the	the	DT
cord-261028-sxux2ujo	70	37	tumor	tumor	NN
cord-261028-sxux2ujo	70	38	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	70	39	.	.	.
cord-261028-sxux2ujo	71	1	(	(	-LRB-
cord-261028-sxux2ujo	71	2	Merad	Merad	NNP
cord-261028-sxux2ujo	71	3	et	et	NNP
cord-261028-sxux2ujo	71	4	al	al	NNP
cord-261028-sxux2ujo	71	5	.	.	NNP
cord-261028-sxux2ujo	71	6	,	,	,
cord-261028-sxux2ujo	71	7	2013	2013	CD
cord-261028-sxux2ujo	71	8	;	;	:
cord-261028-sxux2ujo	71	9	Haniffa	Haniffa	NNP
cord-261028-sxux2ujo	71	10	et	et	FW
cord-261028-sxux2ujo	71	11	al	al	NNP
cord-261028-sxux2ujo	71	12	.	.	NNP
cord-261028-sxux2ujo	71	13	,	,	,
cord-261028-sxux2ujo	71	14	2015	2015	CD
cord-261028-sxux2ujo	72	1	;	;	:
cord-261028-sxux2ujo	72	2	Kashem	Kashem	NNP
cord-261028-sxux2ujo	72	3	et	et	NNP
cord-261028-sxux2ujo	72	4	al	al	NNP
cord-261028-sxux2ujo	72	5	.	.	NNP
cord-261028-sxux2ujo	72	6	,	,	,
cord-261028-sxux2ujo	72	7	2017	2017	CD
cord-261028-sxux2ujo	72	8	)	)	-RRB-
cord-261028-sxux2ujo	72	9	.	.	.
cord-261028-sxux2ujo	73	1	Mouse	mouse	NN
cord-261028-sxux2ujo	73	2	and	and	CC
cord-261028-sxux2ujo	73	3	human	human	JJ
cord-261028-sxux2ujo	73	4	Langerhans	Langerhans	NNP
cord-261028-sxux2ujo	73	5	cells	cell	NNS
cord-261028-sxux2ujo	73	6	(	(	-LRB-
cord-261028-sxux2ujo	73	7	LCs	LCs	NNP
cord-261028-sxux2ujo	73	8	)	)	-RRB-
cord-261028-sxux2ujo	73	9	reside	reside	VBP
cord-261028-sxux2ujo	73	10	in	in	IN
cord-261028-sxux2ujo	73	11	the	the	DT
cord-261028-sxux2ujo	73	12	epidermis	epidermis	NN
cord-261028-sxux2ujo	73	13	and	and	CC
cord-261028-sxux2ujo	73	14	share	share	VB
cord-261028-sxux2ujo	73	15	several	several	JJ
cord-261028-sxux2ujo	73	16	markers	marker	NNS
cord-261028-sxux2ujo	73	17	(	(	-LRB-
cord-261028-sxux2ujo	73	18	CD11c	CD11c	NNP
cord-261028-sxux2ujo	73	19	,	,	,
cord-261028-sxux2ujo	73	20	MHCII	MHCII	NNP
cord-261028-sxux2ujo	73	21	/	/	SYM
cord-261028-sxux2ujo	73	22	HLA	HLA	NNP
cord-261028-sxux2ujo	73	23	-	-	HYPH
cord-261028-sxux2ujo	73	24	DR	DR	NNP
cord-261028-sxux2ujo	73	25	,	,	,
cord-261028-sxux2ujo	73	26	CD11b	CD11b	NNPS
cord-261028-sxux2ujo	73	27	,	,	,
cord-261028-sxux2ujo	73	28	CD172a	CD172a	NNP
cord-261028-sxux2ujo	73	29	,	,	,
cord-261028-sxux2ujo	73	30	langerin	langerin	NNP
cord-261028-sxux2ujo	73	31	,	,	,
cord-261028-sxux2ujo	73	32	EpCAM	EpCAM	NNP
cord-261028-sxux2ujo	73	33	,	,	,
cord-261028-sxux2ujo	73	34	and	and	CC
cord-261028-sxux2ujo	73	35	E	E	NNP
cord-261028-sxux2ujo	73	36	-	-	NN
cord-261028-sxux2ujo	73	37	Cadherin	Cadherin	NNP
cord-261028-sxux2ujo	73	38	)	)	-RRB-
cord-261028-sxux2ujo	73	39	.	.	.
cord-261028-sxux2ujo	74	1	Mouse	Mouse	NNP
cord-261028-sxux2ujo	74	2	LCs	LCs	NNP
cord-261028-sxux2ujo	74	3	further	further	RB
cord-261028-sxux2ujo	74	4	express	express	NNP
cord-261028-sxux2ujo	74	5	CD205	cd205	NN
cord-261028-sxux2ujo	74	6	,	,	,
cord-261028-sxux2ujo	74	7	while	while	IN
cord-261028-sxux2ujo	74	8	human	human	JJ
cord-261028-sxux2ujo	74	9	LCs	LCs	NNP
cord-261028-sxux2ujo	74	10	express	express	VBP
cord-261028-sxux2ujo	74	11	CD1a	CD1a	NNP
cord-261028-sxux2ujo	74	12	and	and	CC
cord-261028-sxux2ujo	74	13	CD1c	CD1c	NNP
cord-261028-sxux2ujo	74	14	.	.	.
cord-261028-sxux2ujo	75	1	Studies	study	NNS
cord-261028-sxux2ujo	75	2	in	in	IN
cord-261028-sxux2ujo	75	3	mice	mouse	NNS
cord-261028-sxux2ujo	75	4	indicate	indicate	VBP
cord-261028-sxux2ujo	75	5	that	that	IN
cord-261028-sxux2ujo	75	6	although	although	IN
cord-261028-sxux2ujo	75	7	LCs	LCs	NNP
cord-261028-sxux2ujo	75	8	share	share	VBP
cord-261028-sxux2ujo	75	9	many	many	JJ
cord-261028-sxux2ujo	75	10	characteristics	characteristic	NNS
cord-261028-sxux2ujo	75	11	with	with	IN
cord-261028-sxux2ujo	75	12	cDC	cDC	NNP
cord-261028-sxux2ujo	75	13	,	,	,
cord-261028-sxux2ujo	75	14	they	-PRON-	PRP
cord-261028-sxux2ujo	75	15	are	be	VBP
cord-261028-sxux2ujo	75	16	resistant	resistant	JJ
cord-261028-sxux2ujo	75	17	to	to	IN
cord-261028-sxux2ujo	75	18	ionizing	ionize	VBG
cord-261028-sxux2ujo	75	19	radiation	radiation	NN
cord-261028-sxux2ujo	75	20	and	and	CC
cord-261028-sxux2ujo	75	21	self	self	NN
cord-261028-sxux2ujo	75	22	-	-	HYPH
cord-261028-sxux2ujo	75	23	renew	renew	VBP
cord-261028-sxux2ujo	75	24	in	in	IN
cord-261028-sxux2ujo	75	25	situ	situ	NN
cord-261028-sxux2ujo	75	26	.	.	.
cord-261028-sxux2ujo	76	1	LCs	lc	NNS
cord-261028-sxux2ujo	76	2	have	have	VBP
cord-261028-sxux2ujo	76	3	been	be	VBN
cord-261028-sxux2ujo	76	4	shown	show	VBN
cord-261028-sxux2ujo	76	5	to	to	TO
cord-261028-sxux2ujo	76	6	cross	cross	VB
cord-261028-sxux2ujo	76	7	-	-	JJ
cord-261028-sxux2ujo	76	8	present	present	JJ
cord-261028-sxux2ujo	76	9	cell	cell	NN
cord-261028-sxux2ujo	76	10	-	-	HYPH
cord-261028-sxux2ujo	76	11	associated	associate	VBN
cord-261028-sxux2ujo	76	12	antigens	antigen	NNS
cord-261028-sxux2ujo	76	13	in	in	IN
cord-261028-sxux2ujo	76	14	vitro	vitro	FW
cord-261028-sxux2ujo	76	15	,	,	,
cord-261028-sxux2ujo	76	16	but	but	CC
cord-261028-sxux2ujo	76	17	their	-PRON-	PRP$
cord-261028-sxux2ujo	76	18	capacity	capacity	NN
cord-261028-sxux2ujo	76	19	to	to	TO
cord-261028-sxux2ujo	76	20	do	do	VB
cord-261028-sxux2ujo	76	21	so	so	RB
cord-261028-sxux2ujo	76	22	in	in	IN
cord-261028-sxux2ujo	76	23	vivo	vivo	NNP
cord-261028-sxux2ujo	76	24	has	have	VBZ
cord-261028-sxux2ujo	76	25	not	not	RB
cord-261028-sxux2ujo	76	26	been	be	VBN
cord-261028-sxux2ujo	76	27	established	establish	VBN
cord-261028-sxux2ujo	76	28	(	(	-LRB-
cord-261028-sxux2ujo	76	29	Igyarto	Igyarto	NNP
cord-261028-sxux2ujo	76	30	and	and	CC
cord-261028-sxux2ujo	76	31	Kaplan	Kaplan	NNP
cord-261028-sxux2ujo	76	32	,	,	,
cord-261028-sxux2ujo	76	33	2013	2013	CD
cord-261028-sxux2ujo	76	34	)	)	-RRB-
cord-261028-sxux2ujo	76	35	.	.	.
cord-261028-sxux2ujo	77	1	The	the	DT
cord-261028-sxux2ujo	77	2	two	two	CD
cord-261028-sxux2ujo	77	3	other	other	JJ
cord-261028-sxux2ujo	77	4	principal	principal	JJ
cord-261028-sxux2ujo	77	5	mouse	mouse	NN
cord-261028-sxux2ujo	77	6	skin	skin	NN
cord-261028-sxux2ujo	77	7	DC	DC	NNP
cord-261028-sxux2ujo	77	8	subsets	subset	NNS
cord-261028-sxux2ujo	77	9	are	be	VBP
cord-261028-sxux2ujo	77	10	cDC1-like	cdc1-like	CD
cord-261028-sxux2ujo	77	11	CD103	cd103	XX
cord-261028-sxux2ujo	78	1	+	+	CC
cord-261028-sxux2ujo	79	1	CD11b	CD11b	NNP
cord-261028-sxux2ujo	79	2	lo	lo	NNP
cord-261028-sxux2ujo	79	3	Langerin	Langerin	NNP
cord-261028-sxux2ujo	79	4	+	+	CC
cord-261028-sxux2ujo	79	5	DCs	DCs	NNP
cord-261028-sxux2ujo	79	6	and	and	CC
cord-261028-sxux2ujo	79	7	cDC2-like	cDC2-like	HYPH
cord-261028-sxux2ujo	79	8	CD103	CD103	NNS
cord-261028-sxux2ujo	79	9	−	−	CD
cord-261028-sxux2ujo	79	10	CD11b	CD11b	NNS
cord-261028-sxux2ujo	80	1	hi	hi	UH
cord-261028-sxux2ujo	80	2	Langerin	Langerin	NNP
cord-261028-sxux2ujo	80	3	−	−	NNP
cord-261028-sxux2ujo	80	4	DCs	dc	NNS
cord-261028-sxux2ujo	80	5	,	,	,
cord-261028-sxux2ujo	80	6	which	which	WDT
cord-261028-sxux2ujo	80	7	reside	reside	VBP
cord-261028-sxux2ujo	80	8	in	in	IN
cord-261028-sxux2ujo	80	9	the	the	DT
cord-261028-sxux2ujo	80	10	dermis	dermis	NN
cord-261028-sxux2ujo	80	11	.	.	.
cord-261028-sxux2ujo	81	1	The	the	DT
cord-261028-sxux2ujo	81	2	CD103	cd103	NN
cord-261028-sxux2ujo	81	3	+	+	CC
cord-261028-sxux2ujo	81	4	dermal	dermal	JJ
cord-261028-sxux2ujo	81	5	DCs	dc	NNS
cord-261028-sxux2ujo	81	6	have	have	VBP
cord-261028-sxux2ujo	81	7	the	the	DT
cord-261028-sxux2ujo	81	8	capacity	capacity	NN
cord-261028-sxux2ujo	81	9	for	for	IN
cord-261028-sxux2ujo	81	10	cross	cross	NN
cord-261028-sxux2ujo	81	11	-	-	JJ
cord-261028-sxux2ujo	81	12	presentation	presentation	NN
cord-261028-sxux2ujo	81	13	of	of	IN
cord-261028-sxux2ujo	81	14	cell	cell	NN
cord-261028-sxux2ujo	81	15	-	-	HYPH
cord-261028-sxux2ujo	81	16	associated	associate	VBN
cord-261028-sxux2ujo	81	17	and	and	CC
cord-261028-sxux2ujo	81	18	particulate	particulate	NN
cord-261028-sxux2ujo	81	19	antigens	antigen	NNS
cord-261028-sxux2ujo	81	20	(	(	-LRB-
cord-261028-sxux2ujo	81	21	Henri	Henri	NNP
cord-261028-sxux2ujo	81	22	et	et	NNP
cord-261028-sxux2ujo	81	23	al	al	NNP
cord-261028-sxux2ujo	81	24	.	.	NNP
cord-261028-sxux2ujo	81	25	,	,	,
cord-261028-sxux2ujo	81	26	2010	2010	CD
cord-261028-sxux2ujo	81	27	;	;	:
cord-261028-sxux2ujo	81	28	Romani	Romani	NNP
cord-261028-sxux2ujo	81	29	et	et	NNP
cord-261028-sxux2ujo	81	30	al	al	NNP
cord-261028-sxux2ujo	81	31	.	.	NNP
cord-261028-sxux2ujo	81	32	,	,	,
cord-261028-sxux2ujo	81	33	2010	2010	CD
cord-261028-sxux2ujo	81	34	;	;	:
cord-261028-sxux2ujo	81	35	Bedoui	Bedoui	NNP
cord-261028-sxux2ujo	81	36	et	et	FW
cord-261028-sxux2ujo	81	37	al	al	NNP
cord-261028-sxux2ujo	81	38	.	.	NNP
cord-261028-sxux2ujo	81	39	,	,	,
cord-261028-sxux2ujo	81	40	2009	2009	CD
cord-261028-sxux2ujo	81	41	)	)	-RRB-
cord-261028-sxux2ujo	81	42	.	.	.
cord-261028-sxux2ujo	82	1	In	in	IN
cord-261028-sxux2ujo	82	2	humans	human	NNS
cord-261028-sxux2ujo	82	3	,	,	,
cord-261028-sxux2ujo	82	4	BDCA-1	BDCA-1	NNP
cord-261028-sxux2ujo	82	5	expression	expression	NN
cord-261028-sxux2ujo	82	6	is	be	VBZ
cord-261028-sxux2ujo	82	7	found	find	VBN
cord-261028-sxux2ujo	82	8	on	on	IN
cord-261028-sxux2ujo	82	9	most	most	JJS
cord-261028-sxux2ujo	82	10	of	of	IN
cord-261028-sxux2ujo	82	11	the	the	DT
cord-261028-sxux2ujo	82	12	dermal	dermal	JJ
cord-261028-sxux2ujo	82	13	DCs	dc	NNS
cord-261028-sxux2ujo	82	14	with	with	IN
cord-261028-sxux2ujo	82	15	the	the	DT
cord-261028-sxux2ujo	82	16	majority	majority	NN
cord-261028-sxux2ujo	82	17	of	of	IN
cord-261028-sxux2ujo	82	18	cells	cell	NNS
cord-261028-sxux2ujo	82	19	co	co	VBD
cord-261028-sxux2ujo	82	20	-	-	NN
cord-261028-sxux2ujo	82	21	expressing	express	VBG
cord-261028-sxux2ujo	82	22	CD11c	CD11c	NNP
cord-261028-sxux2ujo	82	23	and	and	CC
cord-261028-sxux2ujo	82	24	CD1a	CD1a	NNP
cord-261028-sxux2ujo	82	25	.	.	.
cord-261028-sxux2ujo	83	1	Interestingly	interestingly	RB
cord-261028-sxux2ujo	83	2	,	,	,
cord-261028-sxux2ujo	83	3	similarly	similarly	RB
cord-261028-sxux2ujo	83	4	to	to	IN
cord-261028-sxux2ujo	83	5	mice	mouse	NNS
cord-261028-sxux2ujo	83	6	,	,	,
cord-261028-sxux2ujo	83	7	the	the	DT
cord-261028-sxux2ujo	83	8	cDC1-like	cdc1-like	CD
cord-261028-sxux2ujo	83	9	BDCA-3	BDCA-3	NNS
cord-261028-sxux2ujo	83	10	+	+	CC
cord-261028-sxux2ujo	83	11	dermal	dermal	JJ
cord-261028-sxux2ujo	83	12	DCs	dc	NNS
cord-261028-sxux2ujo	83	13	demonstrate	demonstrate	VBP
cord-261028-sxux2ujo	83	14	superior	superior	JJ
cord-261028-sxux2ujo	83	15	cross	cross	JJ
cord-261028-sxux2ujo	83	16	-	-	NN
cord-261028-sxux2ujo	83	17	presentation	presentation	NN
cord-261028-sxux2ujo	83	18	of	of	IN
cord-261028-sxux2ujo	83	19	soluble	soluble	JJ
cord-261028-sxux2ujo	83	20	antigens	antigen	NNS
cord-261028-sxux2ujo	83	21	as	as	IN
cord-261028-sxux2ujo	83	22	compared	compare	VBN
cord-261028-sxux2ujo	83	23	with	with	IN
cord-261028-sxux2ujo	83	24	other	other	JJ
cord-261028-sxux2ujo	83	25	DC	DC	NNP
cord-261028-sxux2ujo	83	26	populations	population	NNS
cord-261028-sxux2ujo	83	27	(	(	-LRB-
cord-261028-sxux2ujo	83	28	Haniffa	Haniffa	NNP
cord-261028-sxux2ujo	83	29	et	et	FW
cord-261028-sxux2ujo	83	30	al	al	NNP
cord-261028-sxux2ujo	83	31	.	.	NNP
cord-261028-sxux2ujo	83	32	,	,	,
cord-261028-sxux2ujo	83	33	2012	2012	CD
cord-261028-sxux2ujo	83	34	)	)	-RRB-
cord-261028-sxux2ujo	83	35	.	.	.
cord-261028-sxux2ujo	84	1	Other	other	JJ
cord-261028-sxux2ujo	84	2	tissue	tissue	NN
cord-261028-sxux2ujo	84	3	DCs	dc	NNS
cord-261028-sxux2ujo	85	1	-Similar	-similar	JJ
cord-261028-sxux2ujo	85	2	to	to	IN
cord-261028-sxux2ujo	85	3	the	the	DT
cord-261028-sxux2ujo	85	4	skin	skin	NN
cord-261028-sxux2ujo	85	5	,	,	,
cord-261028-sxux2ujo	85	6	various	various	JJ
cord-261028-sxux2ujo	85	7	DC	DC	NNP
cord-261028-sxux2ujo	85	8	populations	population	NNS
cord-261028-sxux2ujo	85	9	have	have	VBP
cord-261028-sxux2ujo	85	10	been	be	VBN
cord-261028-sxux2ujo	85	11	identified	identify	VBN
cord-261028-sxux2ujo	85	12	in	in	IN
cord-261028-sxux2ujo	85	13	the	the	DT
cord-261028-sxux2ujo	85	14	intestine	intestine	NN
cord-261028-sxux2ujo	85	15	.	.	.
cord-261028-sxux2ujo	86	1	The	the	DT
cord-261028-sxux2ujo	86	2	mouse	mouse	NN
cord-261028-sxux2ujo	86	3	lamina	lamina	NN
cord-261028-sxux2ujo	86	4	propria	propria	NN
cord-261028-sxux2ujo	86	5	contains	contain	VBZ
cord-261028-sxux2ujo	86	6	2	2	CD
cord-261028-sxux2ujo	86	7	major	major	JJ
cord-261028-sxux2ujo	86	8	populations	population	NNS
cord-261028-sxux2ujo	86	9	,	,	,
cord-261028-sxux2ujo	86	10	CD103	cd103	LS
cord-261028-sxux2ujo	86	11	+	+	SYM
cord-261028-sxux2ujo	86	12	XCR1	XCR1	NNP
cord-261028-sxux2ujo	86	13	+	+	SYM
cord-261028-sxux2ujo	86	14	CD11b	CD11b	NNS
cord-261028-sxux2ujo	86	15	−	−	NNP
cord-261028-sxux2ujo	87	1	CD172	CD172	NNP
cord-261028-sxux2ujo	87	2	−	−	CD
cord-261028-sxux2ujo	87	3	DCs	dc	NNS
cord-261028-sxux2ujo	87	4	that	that	WDT
cord-261028-sxux2ujo	87	5	are	be	VBP
cord-261028-sxux2ujo	87	6	related	relate	VBN
cord-261028-sxux2ujo	87	7	to	to	IN
cord-261028-sxux2ujo	87	8	the	the	DT
cord-261028-sxux2ujo	87	9	Batf3	Batf3	NNP
cord-261028-sxux2ujo	87	10	,	,	,
cord-261028-sxux2ujo	87	11	IFR8	IFR8	NNP
cord-261028-sxux2ujo	87	12	and	and	CC
cord-261028-sxux2ujo	87	13	Id2	id2	JJ
cord-261028-sxux2ujo	87	14	dependent	dependent	JJ
cord-261028-sxux2ujo	88	1	cDC1	cDC1	NNP
cord-261028-sxux2ujo	88	2	and	and	CC
cord-261028-sxux2ujo	88	3	CD103	cd103	NN
cord-261028-sxux2ujo	88	4	+	+	CC
cord-261028-sxux2ujo	89	1	XCR1	XCR1	NNP
cord-261028-sxux2ujo	89	2	−	−	NNP
cord-261028-sxux2ujo	89	3	CD11b	CD11b	NNS
cord-261028-sxux2ujo	90	1	+	+	CC
cord-261028-sxux2ujo	91	1	CD172	CD172	NNP
cord-261028-sxux2ujo	92	1	+	+	CC
cord-261028-sxux2ujo	92	2	DCs	dc	NNS
cord-261028-sxux2ujo	92	3	that	that	WDT
cord-261028-sxux2ujo	92	4	are	be	VBP
cord-261028-sxux2ujo	92	5	related	relate	VBN
cord-261028-sxux2ujo	92	6	to	to	IN
cord-261028-sxux2ujo	92	7	the	the	DT
cord-261028-sxux2ujo	92	8	IRF4	IRF4	NNP
cord-261028-sxux2ujo	92	9	and	and	CC
cord-261028-sxux2ujo	92	10	Notch2	Notch2	NNP
cord-261028-sxux2ujo	92	11	dependent	dependent	JJ
cord-261028-sxux2ujo	92	12	cDC2	cDC2	NNP
cord-261028-sxux2ujo	92	13	.	.	.
cord-261028-sxux2ujo	93	1	In	in	IN
cord-261028-sxux2ujo	93	2	humans	human	NNS
cord-261028-sxux2ujo	93	3	,	,	,
cord-261028-sxux2ujo	93	4	analogous	analogous	JJ
cord-261028-sxux2ujo	93	5	populations	population	NNS
cord-261028-sxux2ujo	93	6	have	have	VBP
cord-261028-sxux2ujo	93	7	been	be	VBN
cord-261028-sxux2ujo	93	8	identified	identify	VBN
cord-261028-sxux2ujo	93	9	,	,	,
cord-261028-sxux2ujo	93	10	and	and	CC
cord-261028-sxux2ujo	93	11	are	be	VBP
cord-261028-sxux2ujo	93	12	divided	divide	VBN
cord-261028-sxux2ujo	93	13	based	base	VBN
cord-261028-sxux2ujo	93	14	on	on	IN
cord-261028-sxux2ujo	93	15	expression	expression	NN
cord-261028-sxux2ujo	93	16	of	of	IN
cord-261028-sxux2ujo	93	17	CD103	CD103	NNS
cord-261028-sxux2ujo	93	18	+	+	CC
cord-261028-sxux2ujo	94	1	XCR1	XCR1	NNP
cord-261028-sxux2ujo	94	2	+	+	CC
cord-261028-sxux2ujo	94	3	CD141	cd141	XX
cord-261028-sxux2ujo	95	1	+	+	CC
cord-261028-sxux2ujo	96	1	Clec9a	Clec9a	NNP
cord-261028-sxux2ujo	96	2	+	+	CC
cord-261028-sxux2ujo	97	1	CD172	CD172	NNP
cord-261028-sxux2ujo	97	2	−	−	NN
cord-261028-sxux2ujo	97	3	and	and	CC
cord-261028-sxux2ujo	98	1	CD103	CD103	NNP
cord-261028-sxux2ujo	98	2	−	−	NNP
cord-261028-sxux2ujo	99	1	XCR1	XCR1	NNP
cord-261028-sxux2ujo	99	2	−	−	NNP
cord-261028-sxux2ujo	100	1	CD141	CD141	NNP
cord-261028-sxux2ujo	101	1	−	−	NNP
cord-261028-sxux2ujo	101	2	Clec9a	clec9a	CC
cord-261028-sxux2ujo	101	3	−	−	NNP
cord-261028-sxux2ujo	102	1	CD172	CD172	NNP
cord-261028-sxux2ujo	102	2	+	+	CC
cord-261028-sxux2ujo	102	3	.	.	.
cord-261028-sxux2ujo	103	1	A	a	DT
cord-261028-sxux2ujo	103	2	smaller	small	JJR
cord-261028-sxux2ujo	103	3	,	,	,
cord-261028-sxux2ujo	103	4	less	less	RBR
cord-261028-sxux2ujo	103	5	studied	study	VBN
cord-261028-sxux2ujo	103	6	CD103	cd103	IN
cord-261028-sxux2ujo	103	7	−	−	CD
cord-261028-sxux2ujo	103	8	XCR1	XCR1	NNP
cord-261028-sxux2ujo	103	9	−	−	NNP
cord-261028-sxux2ujo	103	10	CD11b	CD11b	NNPS
cord-261028-sxux2ujo	103	11	+	+	CC
cord-261028-sxux2ujo	103	12	/	/	SYM
cord-261028-sxux2ujo	103	13	CD172a	cd172a	NN
cord-261028-sxux2ujo	103	14	+	+	CC
cord-261028-sxux2ujo	103	15	population	population	NN
cord-261028-sxux2ujo	103	16	can	can	MD
cord-261028-sxux2ujo	103	17	also	also	RB
cord-261028-sxux2ujo	103	18	be	be	VB
cord-261028-sxux2ujo	103	19	found	find	VBN
cord-261028-sxux2ujo	103	20	in	in	IN
cord-261028-sxux2ujo	103	21	both	both	DT
cord-261028-sxux2ujo	103	22	mouse	mouse	NN
cord-261028-sxux2ujo	103	23	and	and	CC
cord-261028-sxux2ujo	103	24	humans	human	NNS
cord-261028-sxux2ujo	103	25	,	,	,
cord-261028-sxux2ujo	103	26	but	but	CC
cord-261028-sxux2ujo	103	27	its	-PRON-	PRP$
cord-261028-sxux2ujo	103	28	function	function	NN
cord-261028-sxux2ujo	103	29	is	be	VBZ
cord-261028-sxux2ujo	103	30	poorly	poorly	RB
cord-261028-sxux2ujo	103	31	understood	understand	VBN
cord-261028-sxux2ujo	103	32	(	(	-LRB-
cord-261028-sxux2ujo	103	33	Bekiaris	Bekiaris	NNP
cord-261028-sxux2ujo	103	34	et	et	NNP
cord-261028-sxux2ujo	103	35	al	al	NNP
cord-261028-sxux2ujo	103	36	.	.	NNP
cord-261028-sxux2ujo	103	37	,	,	,
cord-261028-sxux2ujo	103	38	2014	2014	CD
cord-261028-sxux2ujo	103	39	)	)	-RRB-
cord-261028-sxux2ujo	103	40	.	.	.
cord-261028-sxux2ujo	104	1	cDC1	cDC1	NNP
cord-261028-sxux2ujo	104	2	and	and	CC
cord-261028-sxux2ujo	104	3	cDC2	cDC2	NNP
cord-261028-sxux2ujo	104	4	like	like	IN
cord-261028-sxux2ujo	104	5	cells	cell	NNS
cord-261028-sxux2ujo	104	6	are	be	VBP
cord-261028-sxux2ujo	104	7	also	also	RB
cord-261028-sxux2ujo	104	8	found	find	VBN
cord-261028-sxux2ujo	104	9	in	in	IN
cord-261028-sxux2ujo	104	10	the	the	DT
cord-261028-sxux2ujo	104	11	lung	lung	NN
cord-261028-sxux2ujo	104	12	,	,	,
cord-261028-sxux2ujo	104	13	with	with	IN
cord-261028-sxux2ujo	104	14	CD103	CD103	NNP
cord-261028-sxux2ujo	104	15	+	+	CC
cord-261028-sxux2ujo	104	16	langerin	langerin	NN
cord-261028-sxux2ujo	104	17	+	+	CC
cord-261028-sxux2ujo	104	18	XCR1	XCR1	NNP
cord-261028-sxux2ujo	104	19	+	+	SYM
cord-261028-sxux2ujo	104	20	Clec9a	Clec9a	NNP
cord-261028-sxux2ujo	104	21	+	+	CC
cord-261028-sxux2ujo	104	22	DC	DC	NNP
cord-261028-sxux2ujo	104	23	displaying	display	VBG
cord-261028-sxux2ujo	104	24	potent	potent	JJ
cord-261028-sxux2ujo	104	25	capacity	capacity	NN
cord-261028-sxux2ujo	104	26	for	for	IN
cord-261028-sxux2ujo	104	27	cross	cross	JJ
cord-261028-sxux2ujo	104	28	-	-	JJ
cord-261028-sxux2ujo	104	29	presentation	presentation	NN
cord-261028-sxux2ujo	104	30	compared	compare	VBN
cord-261028-sxux2ujo	104	31	to	to	IN
cord-261028-sxux2ujo	104	32	their	-PRON-	PRP$
cord-261028-sxux2ujo	104	33	cDC2	cDC2	NNP
cord-261028-sxux2ujo	104	34	−	−	NNP
cord-261028-sxux2ujo	104	35	like	like	IN
cord-261028-sxux2ujo	104	36	CD11b	CD11b	NNS
cord-261028-sxux2ujo	104	37	+	+	CC
cord-261028-sxux2ujo	105	1	CD172	cd172	NN
cord-261028-sxux2ujo	105	2	+	+	CC
cord-261028-sxux2ujo	105	3	counterparts	counterpart	NNS
cord-261028-sxux2ujo	105	4	.	.	.
cord-261028-sxux2ujo	106	1	CD103	CD103	NNP
cord-261028-sxux2ujo	107	1	+	+	CC
cord-261028-sxux2ujo	107	2	/CD141	/CD141	.
cord-261028-sxux2ujo	108	1	+	+	CC
cord-261028-sxux2ujo	109	1	and	and	CC
cord-261028-sxux2ujo	109	2	CD11b/	CD11b/	NNP
cord-261028-sxux2ujo	110	1	CD172	CD172	NNP
cord-261028-sxux2ujo	110	2	+	+	CC
cord-261028-sxux2ujo	111	1	DC	DC	NNP
cord-261028-sxux2ujo	111	2	populations	population	NNS
cord-261028-sxux2ujo	111	3	have	have	VBP
cord-261028-sxux2ujo	111	4	been	be	VBN
cord-261028-sxux2ujo	111	5	identified	identify	VBN
cord-261028-sxux2ujo	111	6	in	in	IN
cord-261028-sxux2ujo	111	7	both	both	DT
cord-261028-sxux2ujo	111	8	human	human	JJ
cord-261028-sxux2ujo	111	9	and	and	CC
cord-261028-sxux2ujo	111	10	murine	murine	JJ
cord-261028-sxux2ujo	111	11	kidney	kidney	NN
cord-261028-sxux2ujo	111	12	and	and	CC
cord-261028-sxux2ujo	111	13	liver	liver	NN
cord-261028-sxux2ujo	111	14	,	,	,
cord-261028-sxux2ujo	111	15	but	but	CC
cord-261028-sxux2ujo	111	16	there	there	EX
cord-261028-sxux2ujo	111	17	is	be	VBZ
cord-261028-sxux2ujo	111	18	currently	currently	RB
cord-261028-sxux2ujo	111	19	limited	limited	JJ
cord-261028-sxux2ujo	111	20	information	information	NN
cord-261028-sxux2ujo	111	21	on	on	IN
cord-261028-sxux2ujo	111	22	their	-PRON-	PRP$
cord-261028-sxux2ujo	111	23	functional	functional	JJ
cord-261028-sxux2ujo	111	24	properties	property	NNS
cord-261028-sxux2ujo	111	25	(	(	-LRB-
cord-261028-sxux2ujo	111	26	Rogers	Rogers	NNP
cord-261028-sxux2ujo	111	27	et	et	NNP
cord-261028-sxux2ujo	111	28	al	al	NNP
cord-261028-sxux2ujo	111	29	.	.	NNP
cord-261028-sxux2ujo	111	30	,	,	,
cord-261028-sxux2ujo	111	31	2014	2014	CD
cord-261028-sxux2ujo	111	32	;	;	.
cord-261028-sxux2ujo	112	1	Rahman	Rahman	NNP
cord-261028-sxux2ujo	112	2	and	and	CC
cord-261028-sxux2ujo	112	3	Aloman	Aloman	NNP
cord-261028-sxux2ujo	112	4	,	,	,
cord-261028-sxux2ujo	112	5	2013	2013	CD
cord-261028-sxux2ujo	112	6	)	)	-RRB-
cord-261028-sxux2ujo	112	7	.	.	.
cord-261028-sxux2ujo	113	1	Several	several	JJ
cord-261028-sxux2ujo	113	2	of	of	IN
cord-261028-sxux2ujo	113	3	these	these	DT
cord-261028-sxux2ujo	113	4	tissue	tissue	NN
cord-261028-sxux2ujo	113	5	-	-	HYPH
cord-261028-sxux2ujo	113	6	associated	associate	VBN
cord-261028-sxux2ujo	113	7	cDC	cDC	NNS
cord-261028-sxux2ujo	113	8	can	can	MD
cord-261028-sxux2ujo	113	9	migrate	migrate	VB
cord-261028-sxux2ujo	113	10	to	to	IN
cord-261028-sxux2ujo	113	11	the	the	DT
cord-261028-sxux2ujo	113	12	draining	drain	VBG
cord-261028-sxux2ujo	113	13	lymph	lymph	NN
cord-261028-sxux2ujo	113	14	nodes	node	NNS
cord-261028-sxux2ujo	113	15	through	through	IN
cord-261028-sxux2ujo	113	16	the	the	DT
cord-261028-sxux2ujo	113	17	lymphatic	lymphatic	JJ
cord-261028-sxux2ujo	113	18	system	system	NN
cord-261028-sxux2ujo	113	19	and	and	CC
cord-261028-sxux2ujo	113	20	are	be	VBP
cord-261028-sxux2ujo	113	21	called	call	VBN
cord-261028-sxux2ujo	113	22	tissue	tissue	NN
cord-261028-sxux2ujo	113	23	-	-	HYPH
cord-261028-sxux2ujo	113	24	migratory	migratory	JJ
cord-261028-sxux2ujo	113	25	cDC	cDC	NNS
cord-261028-sxux2ujo	113	26	.	.	.
cord-261028-sxux2ujo	114	1	The	the	DT
cord-261028-sxux2ujo	114	2	phenotype	phenotype	NN
cord-261028-sxux2ujo	114	3	of	of	IN
cord-261028-sxux2ujo	114	4	these	these	DT
cord-261028-sxux2ujo	114	5	DC	DC	NNP
cord-261028-sxux2ujo	114	6	therefore	therefore	RB
cord-261028-sxux2ujo	114	7	strongly	strongly	RB
cord-261028-sxux2ujo	114	8	correlates	correlate	VBZ
cord-261028-sxux2ujo	114	9	with	with	IN
cord-261028-sxux2ujo	114	10	the	the	DT
cord-261028-sxux2ujo	114	11	phenotype	phenotype	NN
cord-261028-sxux2ujo	114	12	of	of	IN
cord-261028-sxux2ujo	114	13	their	-PRON-	PRP$
cord-261028-sxux2ujo	114	14	tissue	tissue	NN
cord-261028-sxux2ujo	114	15	resident	resident	NN
cord-261028-sxux2ujo	114	16	counterparts	counterpart	NNS
cord-261028-sxux2ujo	114	17	.	.	.
cord-261028-sxux2ujo	115	1	In	in	IN
cord-261028-sxux2ujo	115	2	addition	addition	NN
cord-261028-sxux2ujo	115	3	to	to	IN
cord-261028-sxux2ujo	115	4	these	these	DT
cord-261028-sxux2ujo	115	5	steady	steady	JJ
cord-261028-sxux2ujo	115	6	state	state	NN
cord-261028-sxux2ujo	115	7	DCs	dc	NNS
cord-261028-sxux2ujo	115	8	,	,	,
cord-261028-sxux2ujo	115	9	there	there	EX
cord-261028-sxux2ujo	115	10	are	be	VBP
cord-261028-sxux2ujo	115	11	several	several	JJ
cord-261028-sxux2ujo	115	12	populations	population	NNS
cord-261028-sxux2ujo	115	13	of	of	IN
cord-261028-sxux2ujo	115	14	monocyte	monocyte	NNP
cord-261028-sxux2ujo	115	15	-	-	HYPH
cord-261028-sxux2ujo	115	16	derived	derive	VBN
cord-261028-sxux2ujo	115	17	DC	DC	NNP
cord-261028-sxux2ujo	115	18	(	(	-LRB-
cord-261028-sxux2ujo	115	19	moDC	modc	NN
cord-261028-sxux2ujo	115	20	)	)	-RRB-
cord-261028-sxux2ujo	115	21	which	which	WDT
cord-261028-sxux2ujo	115	22	differ	differ	VBP
cord-261028-sxux2ujo	115	23	from	from	IN
cord-261028-sxux2ujo	115	24	cDC	cDC	NNS
cord-261028-sxux2ujo	115	25	in	in	IN
cord-261028-sxux2ujo	115	26	that	that	IN
cord-261028-sxux2ujo	115	27	they	-PRON-	PRP
cord-261028-sxux2ujo	115	28	are	be	VBP
cord-261028-sxux2ujo	115	29	derived	derive	VBN
cord-261028-sxux2ujo	115	30	from	from	IN
cord-261028-sxux2ujo	115	31	monocytes	monocyte	NNS
cord-261028-sxux2ujo	115	32	and	and	CC
cord-261028-sxux2ujo	115	33	not	not	RB
cord-261028-sxux2ujo	115	34	pre	pre	JJ
cord-261028-sxux2ujo	115	35	-	-	NNS
cord-261028-sxux2ujo	115	36	DCs	dc	NNS
cord-261028-sxux2ujo	115	37	,	,	,
cord-261028-sxux2ujo	115	38	migrating	migrate	VBG
cord-261028-sxux2ujo	115	39	into	into	IN
cord-261028-sxux2ujo	115	40	tissues	tissue	NNS
cord-261028-sxux2ujo	115	41	from	from	IN
cord-261028-sxux2ujo	115	42	the	the	DT
cord-261028-sxux2ujo	115	43	periphery	periphery	NN
cord-261028-sxux2ujo	115	44	.	.	.
cord-261028-sxux2ujo	116	1	Generally	generally	RB
cord-261028-sxux2ujo	116	2	,	,	,
cord-261028-sxux2ujo	116	3	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	116	4	moDC	modc	NN
cord-261028-sxux2ujo	116	5	arise	arise	NN
cord-261028-sxux2ujo	116	6	at	at	IN
cord-261028-sxux2ujo	116	7	the	the	DT
cord-261028-sxux2ujo	116	8	site	site	NN
cord-261028-sxux2ujo	116	9	of	of	IN
cord-261028-sxux2ujo	116	10	inflammation	inflammation	NN
cord-261028-sxux2ujo	116	11	and	and	CC
cord-261028-sxux2ujo	116	12	the	the	DT
cord-261028-sxux2ujo	116	13	local	local	JJ
cord-261028-sxux2ujo	116	14	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	116	15	cues	cue	NNS
cord-261028-sxux2ujo	116	16	prompt	prompt	VBP
cord-261028-sxux2ujo	116	17	their	-PRON-	PRP$
cord-261028-sxux2ujo	116	18	development	development	NN
cord-261028-sxux2ujo	116	19	and	and	CC
cord-261028-sxux2ujo	116	20	functional	functional	JJ
cord-261028-sxux2ujo	116	21	capacities	capacity	NNS
cord-261028-sxux2ujo	116	22	.	.	.
cord-261028-sxux2ujo	117	1	Inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	117	2	moDCs	modcs	CD
cord-261028-sxux2ujo	117	3	have	have	VBP
cord-261028-sxux2ujo	117	4	been	be	VBN
cord-261028-sxux2ujo	117	5	found	find	VBN
cord-261028-sxux2ujo	117	6	in	in	IN
cord-261028-sxux2ujo	117	7	the	the	DT
cord-261028-sxux2ujo	117	8	skin	skin	NN
cord-261028-sxux2ujo	117	9	of	of	IN
cord-261028-sxux2ujo	117	10	patients	patient	NNS
cord-261028-sxux2ujo	117	11	with	with	IN
cord-261028-sxux2ujo	117	12	atopic	atopic	JJ
cord-261028-sxux2ujo	117	13	dermatitis	dermatitis	NN
cord-261028-sxux2ujo	117	14	(	(	-LRB-
cord-261028-sxux2ujo	117	15	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	117	16	dendritic	dendritic	JJ
cord-261028-sxux2ujo	117	17	epithelial	epithelial	JJ
cord-261028-sxux2ujo	117	18	cells	cell	NNS
cord-261028-sxux2ujo	117	19	(	(	-LRB-
cord-261028-sxux2ujo	117	20	IDEC	IDEC	NNP
cord-261028-sxux2ujo	117	21	)	)	-RRB-
cord-261028-sxux2ujo	117	22	)	)	-RRB-
cord-261028-sxux2ujo	117	23	,	,	,
cord-261028-sxux2ujo	117	24	psoriasis	psoriasis	NN
cord-261028-sxux2ujo	117	25	(	(	-LRB-
cord-261028-sxux2ujo	117	26	TNF	TNF	NNP
cord-261028-sxux2ujo	117	27	and	and	CC
cord-261028-sxux2ujo	117	28	iNOS	inos	JJ
cord-261028-sxux2ujo	117	29	producing	produce	VBG
cord-261028-sxux2ujo	117	30	,	,	,
cord-261028-sxux2ujo	117	31	TiP	tip	NN
cord-261028-sxux2ujo	117	32	DCs	DCs	NNP
cord-261028-sxux2ujo	117	33	)	)	-RRB-
cord-261028-sxux2ujo	117	34	,	,	,
cord-261028-sxux2ujo	117	35	and	and	CC
cord-261028-sxux2ujo	117	36	synovial	synovial	JJ
cord-261028-sxux2ujo	117	37	fluid	fluid	NN
cord-261028-sxux2ujo	117	38	of	of	IN
cord-261028-sxux2ujo	117	39	arthritis	arthritis	NN
cord-261028-sxux2ujo	117	40	patients	patient	NNS
cord-261028-sxux2ujo	117	41	(	(	-LRB-
cord-261028-sxux2ujo	117	42	Wollenberg	Wollenberg	NNP
cord-261028-sxux2ujo	117	43	et	et	NNP
cord-261028-sxux2ujo	117	44	al	al	NNP
cord-261028-sxux2ujo	117	45	.	.	NNP
cord-261028-sxux2ujo	117	46	,	,	,
cord-261028-sxux2ujo	117	47	1996	1996	CD
cord-261028-sxux2ujo	117	48	;	;	:
cord-261028-sxux2ujo	117	49	Segura	Segura	NNP
cord-261028-sxux2ujo	117	50	and	and	CC
cord-261028-sxux2ujo	117	51	Amigorena	Amigorena	NNP
cord-261028-sxux2ujo	117	52	,	,	,
cord-261028-sxux2ujo	117	53	2013	2013	CD
cord-261028-sxux2ujo	117	54	)	)	-RRB-
cord-261028-sxux2ujo	117	55	.	.	.
cord-261028-sxux2ujo	118	1	These	these	DT
cord-261028-sxux2ujo	118	2	types	type	NNS
cord-261028-sxux2ujo	118	3	of	of	IN
cord-261028-sxux2ujo	118	4	moDC	moDC	NNP
cord-261028-sxux2ujo	118	5	express	express	VB
cord-261028-sxux2ujo	118	6	CD11c	CD11c	NNP
cord-261028-sxux2ujo	118	7	,	,	,
cord-261028-sxux2ujo	118	8	MHCII	MHCII	NNP
cord-261028-sxux2ujo	118	9	,	,	,
cord-261028-sxux2ujo	118	10	CD11b	CD11b	NNPS
cord-261028-sxux2ujo	118	11	,	,	,
cord-261028-sxux2ujo	118	12	Ly6C	Ly6C	NNP
cord-261028-sxux2ujo	118	13	,	,	,
cord-261028-sxux2ujo	118	14	and	and	CC
cord-261028-sxux2ujo	118	15	CD206	CD206	NNP
cord-261028-sxux2ujo	118	16	(	(	-LRB-
cord-261028-sxux2ujo	118	17	mouse	mouse	NN
cord-261028-sxux2ujo	118	18	)	)	-RRB-
cord-261028-sxux2ujo	118	19	and	and	CC
cord-261028-sxux2ujo	118	20	CD11c	CD11c	NNP
cord-261028-sxux2ujo	118	21	,	,	,
cord-261028-sxux2ujo	118	22	HLA	HLA	NNP
cord-261028-sxux2ujo	118	23	-	-	HYPH
cord-261028-sxux2ujo	118	24	DR	DR	NNP
cord-261028-sxux2ujo	118	25	,	,	,
cord-261028-sxux2ujo	118	26	BDCA1	bdca1	NN
cord-261028-sxux2ujo	118	27	,	,	,
cord-261028-sxux2ujo	118	28	CD1a	CD1a	NNP
cord-261028-sxux2ujo	118	29	,	,	,
cord-261028-sxux2ujo	118	30	FceR1	FceR1	NNP
cord-261028-sxux2ujo	118	31	,	,	,
cord-261028-sxux2ujo	118	32	CD206	CD206	NNP
cord-261028-sxux2ujo	118	33	,	,	,
cord-261028-sxux2ujo	118	34	CD172a	CD172a	NNP
cord-261028-sxux2ujo	118	35	,	,	,
cord-261028-sxux2ujo	118	36	CD14	CD14	NNP
cord-261028-sxux2ujo	118	37	and	and	CC
cord-261028-sxux2ujo	118	38	CD11b	CD11b	NNPS
cord-261028-sxux2ujo	118	39	(	(	-LRB-
cord-261028-sxux2ujo	118	40	human	human	NN
cord-261028-sxux2ujo	118	41	)	)	-RRB-
cord-261028-sxux2ujo	118	42	.	.	.
cord-261028-sxux2ujo	119	1	The	the	DT
cord-261028-sxux2ujo	119	2	development	development	NN
cord-261028-sxux2ujo	119	3	of	of	IN
cord-261028-sxux2ujo	119	4	both	both	CC
cord-261028-sxux2ujo	119	5	human	human	JJ
cord-261028-sxux2ujo	119	6	and	and	CC
cord-261028-sxux2ujo	119	7	mouse	mouse	NN
cord-261028-sxux2ujo	119	8	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	119	9	moDCs	moDCs	NNP
cord-261028-sxux2ujo	119	10	seems	seem	VBZ
cord-261028-sxux2ujo	119	11	to	to	TO
cord-261028-sxux2ujo	119	12	depend	depend	VB
cord-261028-sxux2ujo	119	13	on	on	IN
cord-261028-sxux2ujo	119	14	transcription	transcription	NN
cord-261028-sxux2ujo	119	15	factor	factor	NN
cord-261028-sxux2ujo	119	16	Zbtb46	zbtb46	NN
cord-261028-sxux2ujo	119	17	and	and	CC
cord-261028-sxux2ujo	119	18	growth	growth	NN
cord-261028-sxux2ujo	119	19	factor	factor	NN
cord-261028-sxux2ujo	119	20	M	M	NNP
cord-261028-sxux2ujo	119	21	-	-	HYPH
cord-261028-sxux2ujo	119	22	CSF	CSF	NNP
cord-261028-sxux2ujo	119	23	(	(	-LRB-
cord-261028-sxux2ujo	119	24	Segura	Segura	NNP
cord-261028-sxux2ujo	119	25	and	and	CC
cord-261028-sxux2ujo	119	26	Amigorena	Amigorena	NNP
cord-261028-sxux2ujo	119	27	,	,	,
cord-261028-sxux2ujo	119	28	2013	2013	CD
cord-261028-sxux2ujo	119	29	)	)	-RRB-
cord-261028-sxux2ujo	119	30	.	.	.
cord-261028-sxux2ujo	120	1	While	while	IN
cord-261028-sxux2ujo	120	2	in	in	IN
cord-261028-sxux2ujo	120	3	vivo	vivo	FW
cord-261028-sxux2ujo	120	4	cross	cross	NN
cord-261028-sxux2ujo	120	5	-	-	NN
cord-261028-sxux2ujo	120	6	presentation	presentation	NN
cord-261028-sxux2ujo	120	7	of	of	IN
cord-261028-sxux2ujo	120	8	cell	cell	NN
cord-261028-sxux2ujo	120	9	-	-	HYPH
cord-261028-sxux2ujo	120	10	associated	associate	VBN
cord-261028-sxux2ujo	120	11	antigens	antigen	NNS
cord-261028-sxux2ujo	120	12	has	have	VBZ
cord-261028-sxux2ujo	120	13	not	not	RB
cord-261028-sxux2ujo	120	14	been	be	VBN
cord-261028-sxux2ujo	120	15	well	well	RB
cord-261028-sxux2ujo	120	16	established	establish	VBN
cord-261028-sxux2ujo	120	17	by	by	IN
cord-261028-sxux2ujo	120	18	this	this	DT
cord-261028-sxux2ujo	120	19	subset	subset	JJ
cord-261028-sxux2ujo	120	20	,	,	,
cord-261028-sxux2ujo	120	21	in	in	IN
cord-261028-sxux2ujo	120	22	vitro	vitro	FW
cord-261028-sxux2ujo	120	23	generated	generate	VBD
cord-261028-sxux2ujo	120	24	human	human	NN
cord-261028-sxux2ujo	120	25	and	and	CC
cord-261028-sxux2ujo	120	26	mouse	mouse	NN
cord-261028-sxux2ujo	120	27	DCs	DCs	NNP
cord-261028-sxux2ujo	120	28	can	can	MD
cord-261028-sxux2ujo	120	29	efficiently	efficiently	RB
cord-261028-sxux2ujo	120	30	crosspresent	crosspresent	VB
cord-261028-sxux2ujo	120	31	cell	cell	NN
cord-261028-sxux2ujo	120	32	-	-	HYPH
cord-261028-sxux2ujo	120	33	associated	associate	VBN
cord-261028-sxux2ujo	120	34	and	and	CC
cord-261028-sxux2ujo	120	35	soluble	soluble	JJ
cord-261028-sxux2ujo	120	36	antigens	antigen	NNS
cord-261028-sxux2ujo	120	37	.	.	.
cord-261028-sxux2ujo	121	1	relative	relative	JJ
cord-261028-sxux2ujo	121	2	composition	composition	NN
cord-261028-sxux2ujo	121	3	and	and	CC
cord-261028-sxux2ujo	121	4	functionality	functionality	NN
cord-261028-sxux2ujo	121	5	of	of	IN
cord-261028-sxux2ujo	121	6	TIDCs	TIDCs	NNPS
cord-261028-sxux2ujo	121	7	is	be	VBZ
cord-261028-sxux2ujo	121	8	strongly	strongly	RB
cord-261028-sxux2ujo	121	9	dictated	dictate	VBN
cord-261028-sxux2ujo	121	10	by	by	IN
cord-261028-sxux2ujo	121	11	the	the	DT
cord-261028-sxux2ujo	121	12	tumor	tumor	NN
cord-261028-sxux2ujo	121	13	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	121	14	,	,	,
cord-261028-sxux2ujo	121	15	and	and	CC
cord-261028-sxux2ujo	121	16	can	can	MD
cord-261028-sxux2ujo	121	17	be	be	VB
cord-261028-sxux2ujo	121	18	highly	highly	RB
cord-261028-sxux2ujo	121	19	dynamic	dynamic	JJ
cord-261028-sxux2ujo	121	20	,	,	,
cord-261028-sxux2ujo	121	21	depending	depend	VBG
cord-261028-sxux2ujo	121	22	on	on	IN
cord-261028-sxux2ujo	121	23	factors	factor	NNS
cord-261028-sxux2ujo	121	24	such	such	JJ
cord-261028-sxux2ujo	121	25	as	as	IN
cord-261028-sxux2ujo	121	26	tumor	tumor	NN
cord-261028-sxux2ujo	121	27	growth	growth	NN
cord-261028-sxux2ujo	121	28	rate	rate	NN
cord-261028-sxux2ujo	121	29	,	,	,
cord-261028-sxux2ujo	121	30	vascularization	vascularization	NN
cord-261028-sxux2ujo	121	31	and	and	CC
cord-261028-sxux2ujo	121	32	hypoxia	hypoxia	NN
cord-261028-sxux2ujo	121	33	,	,	,
cord-261028-sxux2ujo	121	34	accumulation	accumulation	NN
cord-261028-sxux2ujo	121	35	of	of	IN
cord-261028-sxux2ujo	121	36	other	other	JJ
cord-261028-sxux2ujo	121	37	leukocytes	leukocyte	NNS
cord-261028-sxux2ujo	121	38	,	,	,
cord-261028-sxux2ujo	121	39	and	and	CC
cord-261028-sxux2ujo	121	40	cytokines	cytokine	NNS
cord-261028-sxux2ujo	121	41	and	and	CC
cord-261028-sxux2ujo	121	42	other	other	JJ
cord-261028-sxux2ujo	121	43	soluble	soluble	JJ
cord-261028-sxux2ujo	121	44	factors	factor	NNS
cord-261028-sxux2ujo	121	45	secreted	secrete	VBN
cord-261028-sxux2ujo	121	46	by	by	IN
cord-261028-sxux2ujo	121	47	neoplastic	neoplastic	JJ
cord-261028-sxux2ujo	121	48	cells	cell	NNS
cord-261028-sxux2ujo	121	49	.	.	.
cord-261028-sxux2ujo	122	1	The	the	DT
cord-261028-sxux2ujo	122	2	frequency	frequency	NN
cord-261028-sxux2ujo	122	3	of	of	IN
cord-261028-sxux2ujo	122	4	TIDCs	TIDCs	NNP
cord-261028-sxux2ujo	122	5	correlates	correlate	VBZ
cord-261028-sxux2ujo	122	6	with	with	IN
cord-261028-sxux2ujo	122	7	favorable	favorable	JJ
cord-261028-sxux2ujo	122	8	prognosis	prognosis	NN
cord-261028-sxux2ujo	122	9	and	and	CC
cord-261028-sxux2ujo	122	10	is	be	VBZ
cord-261028-sxux2ujo	122	11	inversely	inversely	RB
cord-261028-sxux2ujo	122	12	correlated	correlate	VBN
cord-261028-sxux2ujo	122	13	with	with	IN
cord-261028-sxux2ujo	122	14	tumor	tumor	NN
cord-261028-sxux2ujo	122	15	pathologic	pathologic	JJ
cord-261028-sxux2ujo	122	16	stage	stage	NN
cord-261028-sxux2ujo	122	17	in	in	IN
cord-261028-sxux2ujo	122	18	a	a	DT
cord-261028-sxux2ujo	122	19	variety	variety	NN
cord-261028-sxux2ujo	122	20	of	of	IN
cord-261028-sxux2ujo	122	21	cancers	cancer	NNS
cord-261028-sxux2ujo	123	1	(	(	-LRB-
cord-261028-sxux2ujo	123	2	Karthaus	Karthaus	NNP
cord-261028-sxux2ujo	123	3	et	et	NNP
cord-261028-sxux2ujo	123	4	al	al	NNP
cord-261028-sxux2ujo	123	5	.	.	.
cord-261028-sxux2ujo	124	1	,	,	,
cord-261028-sxux2ujo	124	2	2012	2012	CD
cord-261028-sxux2ujo	124	3	;	;	:
cord-261028-sxux2ujo	124	4	Ladanyi	Ladanyi	NNP
cord-261028-sxux2ujo	124	5	et	et	NNP
cord-261028-sxux2ujo	124	6	al	al	NNP
cord-261028-sxux2ujo	124	7	.	.	NNP
cord-261028-sxux2ujo	124	8	,	,	,
cord-261028-sxux2ujo	124	9	2007	2007	CD
cord-261028-sxux2ujo	124	10	;	;	:
cord-261028-sxux2ujo	124	11	Reichert	Reichert	NNP
cord-261028-sxux2ujo	124	12	et	et	NNP
cord-261028-sxux2ujo	124	13	al	al	NNP
cord-261028-sxux2ujo	124	14	.	.	NNP
cord-261028-sxux2ujo	124	15	,	,	,
cord-261028-sxux2ujo	124	16	2001	2001	CD
cord-261028-sxux2ujo	124	17	)	)	-RRB-
cord-261028-sxux2ujo	124	18	.	.	.
cord-261028-sxux2ujo	125	1	Due	due	IN
cord-261028-sxux2ujo	125	2	to	to	IN
cord-261028-sxux2ujo	125	3	their	-PRON-	PRP$
cord-261028-sxux2ujo	125	4	role	role	NN
cord-261028-sxux2ujo	125	5	in	in	IN
cord-261028-sxux2ujo	125	6	initiating	initiate	VBG
cord-261028-sxux2ujo	125	7	anti	anti	JJ
cord-261028-sxux2ujo	125	8	-	-	JJ
cord-261028-sxux2ujo	125	9	tumor	tumor	JJ
cord-261028-sxux2ujo	125	10	immunity	immunity	NN
cord-261028-sxux2ujo	125	11	,	,	,
cord-261028-sxux2ujo	125	12	there	there	EX
cord-261028-sxux2ujo	125	13	is	be	VBZ
cord-261028-sxux2ujo	125	14	a	a	DT
cord-261028-sxux2ujo	125	15	negative	negative	JJ
cord-261028-sxux2ujo	125	16	selective	selective	JJ
cord-261028-sxux2ujo	125	17	pressure	pressure	NN
cord-261028-sxux2ujo	125	18	hampering	hamper	VBG
cord-261028-sxux2ujo	125	19	the	the	DT
cord-261028-sxux2ujo	125	20	accumulation	accumulation	NN
cord-261028-sxux2ujo	125	21	of	of	IN
cord-261028-sxux2ujo	125	22	DCs	dc	NNS
cord-261028-sxux2ujo	125	23	by	by	IN
cord-261028-sxux2ujo	125	24	tumor	tumor	NN
cord-261028-sxux2ujo	125	25	-	-	HYPH
cord-261028-sxux2ujo	125	26	secreted	secrete	VBN
cord-261028-sxux2ujo	125	27	mediators	mediator	NNS
cord-261028-sxux2ujo	125	28	that	that	WDT
cord-261028-sxux2ujo	125	29	inhibit	inhibit	VBP
cord-261028-sxux2ujo	125	30	dendropoiesis	dendropoiesis	NN
cord-261028-sxux2ujo	125	31	,	,	,
cord-261028-sxux2ujo	125	32	promote	promote	VB
cord-261028-sxux2ujo	125	33	DC	DC	NNP
cord-261028-sxux2ujo	125	34	apoptosis	apoptosis	NN
cord-261028-sxux2ujo	125	35	,	,	,
cord-261028-sxux2ujo	125	36	and	and	CC
cord-261028-sxux2ujo	125	37	accelerate	accelerate	VB
cord-261028-sxux2ujo	125	38	DC	DC	NNP
cord-261028-sxux2ujo	125	39	turnover	turnover	NN
cord-261028-sxux2ujo	125	40	(	(	-LRB-
cord-261028-sxux2ujo	125	41	Esche	Esche	NNP
cord-261028-sxux2ujo	125	42	et	et	NNP
cord-261028-sxux2ujo	125	43	al	al	NNP
cord-261028-sxux2ujo	125	44	.	.	NNP
cord-261028-sxux2ujo	125	45	,	,	,
cord-261028-sxux2ujo	125	46	1999	1999	CD
cord-261028-sxux2ujo	125	47	;	;	:
cord-261028-sxux2ujo	126	1	Pirtskhalaishvili	Pirtskhalaishvili	NNP
cord-261028-sxux2ujo	126	2	et	et	NNP
cord-261028-sxux2ujo	126	3	al	al	NNP
cord-261028-sxux2ujo	126	4	.	.	NNP
cord-261028-sxux2ujo	126	5	,	,	,
cord-261028-sxux2ujo	126	6	2000	2000	CD
cord-261028-sxux2ujo	127	1	;	;	:
cord-261028-sxux2ujo	127	2	Peguet	Peguet	NNP
cord-261028-sxux2ujo	127	3	-	-	HYPH
cord-261028-sxux2ujo	127	4	Navarro	Navarro	NNP
cord-261028-sxux2ujo	127	5	et	et	NNP
cord-261028-sxux2ujo	127	6	al	al	NNP
cord-261028-sxux2ujo	127	7	.	.	NNP
cord-261028-sxux2ujo	127	8	,	,	,
cord-261028-sxux2ujo	127	9	2003	2003	CD
cord-261028-sxux2ujo	127	10	;	;	:
cord-261028-sxux2ujo	127	11	Kiertscher	Kiertscher	NNP
cord-261028-sxux2ujo	127	12	et	et	NNP
cord-261028-sxux2ujo	127	13	al	al	NNP
cord-261028-sxux2ujo	127	14	.	.	NNP
cord-261028-sxux2ujo	127	15	,	,	,
cord-261028-sxux2ujo	127	16	2000	2000	CD
cord-261028-sxux2ujo	127	17	)	)	-RRB-
cord-261028-sxux2ujo	127	18	.	.	.
cord-261028-sxux2ujo	128	1	Moreover	moreover	RB
cord-261028-sxux2ujo	128	2	,	,	,
cord-261028-sxux2ujo	128	3	the	the	DT
cord-261028-sxux2ujo	128	4	tumor	tumor	NN
cord-261028-sxux2ujo	128	5	and	and	CC
cord-261028-sxux2ujo	128	6	its	-PRON-	PRP$
cord-261028-sxux2ujo	128	7	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	128	8	actively	actively	RB
cord-261028-sxux2ujo	128	9	exploit	exploit	VBP
cord-261028-sxux2ujo	128	10	various	various	JJ
cord-261028-sxux2ujo	128	11	mechanisms	mechanism	NNS
cord-261028-sxux2ujo	128	12	to	to	TO
cord-261028-sxux2ujo	128	13	suppress	suppress	VB
cord-261028-sxux2ujo	128	14	proinflammatory	proinflammatory	JJ
cord-261028-sxux2ujo	128	15	functions	function	NNS
cord-261028-sxux2ujo	128	16	of	of	IN
cord-261028-sxux2ujo	128	17	infiltrating	infiltrate	VBG
cord-261028-sxux2ujo	128	18	DCs	dc	NNS
cord-261028-sxux2ujo	128	19	and	and	CC
cord-261028-sxux2ujo	128	20	even	even	RB
cord-261028-sxux2ujo	128	21	induce	induce	VB
cord-261028-sxux2ujo	128	22	DCs	dc	NNS
cord-261028-sxux2ujo	128	23	to	to	TO
cord-261028-sxux2ujo	128	24	suppress	suppress	VB
cord-261028-sxux2ujo	128	25	immune	immune	JJ
cord-261028-sxux2ujo	128	26	responses	response	NNS
cord-261028-sxux2ujo	128	27	,	,	,
cord-261028-sxux2ujo	128	28	and	and	CC
cord-261028-sxux2ujo	128	29	promote	promote	VB
cord-261028-sxux2ujo	128	30	immune	immune	JJ
cord-261028-sxux2ujo	128	31	tolerance	tolerance	NN
cord-261028-sxux2ujo	128	32	,	,	,
cord-261028-sxux2ujo	128	33	tumor	tumor	NN
cord-261028-sxux2ujo	128	34	vascularization	vascularization	NN
cord-261028-sxux2ujo	128	35	,	,	,
cord-261028-sxux2ujo	128	36	and	and	CC
cord-261028-sxux2ujo	128	37	metastases	metastasis	NNS
cord-261028-sxux2ujo	128	38	(	(	-LRB-
cord-261028-sxux2ujo	128	39	Ma	Ma	NNP
cord-261028-sxux2ujo	128	40	et	et	FW
cord-261028-sxux2ujo	128	41	al	al	NNP
cord-261028-sxux2ujo	128	42	.	.	NNP
cord-261028-sxux2ujo	128	43	,	,	,
cord-261028-sxux2ujo	128	44	2012	2012	CD
cord-261028-sxux2ujo	128	45	;	;	.
cord-261028-sxux2ujo	129	1	Ma	Ma	NNP
cord-261028-sxux2ujo	129	2	et	et	NNP
cord-261028-sxux2ujo	129	3	al	al	NNP
cord-261028-sxux2ujo	129	4	.	.	.
cord-261028-sxux2ujo	130	1	,	,	,
cord-261028-sxux2ujo	130	2	2013	2013	CD
cord-261028-sxux2ujo	130	3	;	;	:
cord-261028-sxux2ujo	130	4	Tran	Tran	NNP
cord-261028-sxux2ujo	130	5	Janco	Janco	NNP
cord-261028-sxux2ujo	130	6	et	et	NNP
cord-261028-sxux2ujo	130	7	al	al	NNP
cord-261028-sxux2ujo	130	8	.	.	NNP
cord-261028-sxux2ujo	130	9	,	,	,
cord-261028-sxux2ujo	130	10	2015	2015	CD
cord-261028-sxux2ujo	130	11	;	;	:
cord-261028-sxux2ujo	130	12	Chaput	Chaput	NNP
cord-261028-sxux2ujo	130	13	et	et	NNP
cord-261028-sxux2ujo	130	14	al	al	NNP
cord-261028-sxux2ujo	130	15	.	.	NNP
cord-261028-sxux2ujo	130	16	,	,	,
cord-261028-sxux2ujo	130	17	2008	2008	CD
cord-261028-sxux2ujo	130	18	)	)	-RRB-
cord-261028-sxux2ujo	130	19	.	.	.
cord-261028-sxux2ujo	131	1	In	in	IN
cord-261028-sxux2ujo	131	2	order	order	NN
cord-261028-sxux2ujo	131	3	to	to	TO
cord-261028-sxux2ujo	131	4	generate	generate	VB
cord-261028-sxux2ujo	131	5	tumor	tumor	NN
cord-261028-sxux2ujo	131	6	-	-	HYPH
cord-261028-sxux2ujo	131	7	specific	specific	JJ
cord-261028-sxux2ujo	131	8	T	t	NN
cord-261028-sxux2ujo	131	9	cell	cell	NN
cord-261028-sxux2ujo	131	10	responses	response	NNS
cord-261028-sxux2ujo	131	11	,	,	,
cord-261028-sxux2ujo	131	12	DCs	DCs	NNP
cord-261028-sxux2ujo	131	13	must	must	MD
cord-261028-sxux2ujo	131	14	endocytose	endocytose	VB
cord-261028-sxux2ujo	131	15	tumor	tumor	NN
cord-261028-sxux2ujo	131	16	antigens	antigen	NNS
cord-261028-sxux2ujo	131	17	,	,	,
cord-261028-sxux2ujo	131	18	process	process	VB
cord-261028-sxux2ujo	131	19	them	-PRON-	PRP
cord-261028-sxux2ujo	131	20	and	and	CC
cord-261028-sxux2ujo	131	21	present	present	VB
cord-261028-sxux2ujo	131	22	them	-PRON-	PRP
cord-261028-sxux2ujo	131	23	in	in	IN
cord-261028-sxux2ujo	131	24	the	the	DT
cord-261028-sxux2ujo	131	25	context	context	NN
cord-261028-sxux2ujo	131	26	of	of	IN
cord-261028-sxux2ujo	131	27	MHC	MHC	NNP
cord-261028-sxux2ujo	131	28	along	along	IN
cord-261028-sxux2ujo	131	29	with	with	IN
cord-261028-sxux2ujo	131	30	co	co	JJ
cord-261028-sxux2ujo	131	31	-	-	JJ
cord-261028-sxux2ujo	131	32	stimulatory	stimulatory	JJ
cord-261028-sxux2ujo	131	33	molecules	molecule	NNS
cord-261028-sxux2ujo	131	34	and	and	CC
cord-261028-sxux2ujo	131	35	cytokines	cytokine	NNS
cord-261028-sxux2ujo	131	36	.	.	.
cord-261028-sxux2ujo	132	1	The	the	DT
cord-261028-sxux2ujo	132	2	MHC	MHC	NNP
cord-261028-sxux2ujo	132	3	/	/	SYM
cord-261028-sxux2ujo	132	4	peptide	peptide	NN
cord-261028-sxux2ujo	132	5	complex	complex	NN
cord-261028-sxux2ujo	132	6	of	of	IN
cord-261028-sxux2ujo	132	7	tumor	tumor	NN
cord-261028-sxux2ujo	132	8	antigens	antigen	NNS
cord-261028-sxux2ujo	132	9	provides	provide	VBZ
cord-261028-sxux2ujo	132	10	the	the	DT
cord-261028-sxux2ujo	132	11	first	first	JJ
cord-261028-sxux2ujo	132	12	of	of	IN
cord-261028-sxux2ujo	132	13	three	three	CD
cord-261028-sxux2ujo	132	14	signals	signal	NNS
cord-261028-sxux2ujo	132	15	needed	need	VBN
cord-261028-sxux2ujo	132	16	for	for	IN
cord-261028-sxux2ujo	132	17	optimal	optimal	JJ
cord-261028-sxux2ujo	132	18	T	T	NNP
cord-261028-sxux2ujo	132	19	cell	cell	NN
cord-261028-sxux2ujo	132	20	activation	activation	NN
cord-261028-sxux2ujo	132	21	.	.	.
cord-261028-sxux2ujo	133	1	The	the	DT
cord-261028-sxux2ujo	133	2	MHC	MHC	NNP
cord-261028-sxux2ujo	133	3	/	/	SYM
cord-261028-sxux2ujo	133	4	peptide	peptide	NN
cord-261028-sxux2ujo	133	5	complex	complex	NN
cord-261028-sxux2ujo	133	6	is	be	VBZ
cord-261028-sxux2ujo	133	7	recognized	recognize	VBN
cord-261028-sxux2ujo	133	8	by	by	IN
cord-261028-sxux2ujo	133	9	its	-PRON-	PRP$
cord-261028-sxux2ujo	133	10	cognate	cognate	JJ
cord-261028-sxux2ujo	133	11	T	t	NN
cord-261028-sxux2ujo	133	12	cell	cell	NN
cord-261028-sxux2ujo	133	13	receptor	receptor	NN
cord-261028-sxux2ujo	133	14	(	(	-LRB-
cord-261028-sxux2ujo	133	15	TCR	TCR	NNP
cord-261028-sxux2ujo	133	16	)	)	-RRB-
cord-261028-sxux2ujo	133	17	on	on	IN
cord-261028-sxux2ujo	133	18	naïve	naïve	JJ
cord-261028-sxux2ujo	133	19	T	T	NNP
cord-261028-sxux2ujo	133	20	cells	cell	NNS
cord-261028-sxux2ujo	133	21	in	in	IN
cord-261028-sxux2ujo	133	22	the	the	DT
cord-261028-sxux2ujo	133	23	draining	drain	VBG
cord-261028-sxux2ujo	133	24	lymphoid	lymphoid	JJ
cord-261028-sxux2ujo	133	25	tissue	tissue	NN
cord-261028-sxux2ujo	133	26	,	,	,
cord-261028-sxux2ujo	133	27	and	and	CC
cord-261028-sxux2ujo	133	28	the	the	DT
cord-261028-sxux2ujo	133	29	strength	strength	NN
cord-261028-sxux2ujo	133	30	of	of	IN
cord-261028-sxux2ujo	133	31	T	T	NNP
cord-261028-sxux2ujo	133	32	cell	cell	NN
cord-261028-sxux2ujo	133	33	activation	activation	NN
cord-261028-sxux2ujo	133	34	correlates	correlate	VBZ
cord-261028-sxux2ujo	133	35	with	with	IN
cord-261028-sxux2ujo	133	36	the	the	DT
cord-261028-sxux2ujo	133	37	MHC	MHC	NNP
cord-261028-sxux2ujo	133	38	/	/	SYM
cord-261028-sxux2ujo	133	39	peptide	peptide	NN
cord-261028-sxux2ujo	133	40	complex	complex	JJ
cord-261028-sxux2ujo	133	41	density	density	NN
cord-261028-sxux2ujo	133	42	on	on	IN
cord-261028-sxux2ujo	133	43	the	the	DT
cord-261028-sxux2ujo	133	44	DC	DC	NNP
cord-261028-sxux2ujo	133	45	as	as	RB
cord-261028-sxux2ujo	133	46	well	well	RB
cord-261028-sxux2ujo	133	47	as	as	IN
cord-261028-sxux2ujo	133	48	the	the	DT
cord-261028-sxux2ujo	133	49	TCR	TCR	NNP
cord-261028-sxux2ujo	133	50	affinity	affinity	NN
cord-261028-sxux2ujo	133	51	for	for	IN
cord-261028-sxux2ujo	133	52	these	these	DT
cord-261028-sxux2ujo	133	53	complexed	complexed	JJ
cord-261028-sxux2ujo	133	54	peptide	peptide	NN
cord-261028-sxux2ujo	133	55	antigens	antigen	NNS
cord-261028-sxux2ujo	133	56	.	.	.
cord-261028-sxux2ujo	134	1	The	the	DT
cord-261028-sxux2ujo	134	2	second	second	JJ
cord-261028-sxux2ujo	134	3	signal	signal	NN
cord-261028-sxux2ujo	134	4	derives	derive	VBZ
cord-261028-sxux2ujo	134	5	from	from	IN
cord-261028-sxux2ujo	134	6	interactions	interaction	NNS
cord-261028-sxux2ujo	134	7	of	of	IN
cord-261028-sxux2ujo	134	8	membrane	membrane	NN
cord-261028-sxux2ujo	134	9	associated	associate	VBN
cord-261028-sxux2ujo	134	10	co	co	JJ
cord-261028-sxux2ujo	134	11	-	-	JJ
cord-261028-sxux2ujo	134	12	stimulatory	stimulatory	JJ
cord-261028-sxux2ujo	134	13	molecules	molecule	NNS
cord-261028-sxux2ujo	134	14	in	in	IN
cord-261028-sxux2ujo	134	15	the	the	DT
cord-261028-sxux2ujo	134	16	synapse	synapse	NN
cord-261028-sxux2ujo	134	17	of	of	IN
cord-261028-sxux2ujo	134	18	T	T	NNP
cord-261028-sxux2ujo	134	19	cells	cell	NNS
cord-261028-sxux2ujo	134	20	and	and	CC
cord-261028-sxux2ujo	134	21	DCs	dc	NNS
cord-261028-sxux2ujo	134	22	.	.	.
cord-261028-sxux2ujo	135	1	This	this	DT
cord-261028-sxux2ujo	135	2	signal	signal	NN
cord-261028-sxux2ujo	135	3	is	be	VBZ
cord-261028-sxux2ujo	135	4	mediated	mediate	VBN
cord-261028-sxux2ujo	135	5	by	by	IN
cord-261028-sxux2ujo	135	6	co	co	JJ
cord-261028-sxux2ujo	135	7	-	-	JJ
cord-261028-sxux2ujo	135	8	stimulatory	stimulatory	JJ
cord-261028-sxux2ujo	135	9	molecules	molecule	NNS
cord-261028-sxux2ujo	135	10	and	and	CC
cord-261028-sxux2ujo	135	11	their	-PRON-	PRP$
cord-261028-sxux2ujo	135	12	ligands	ligand	NNS
cord-261028-sxux2ujo	135	13	,	,	,
cord-261028-sxux2ujo	135	14	including	include	VBG
cord-261028-sxux2ujo	135	15	CD28-CD80	CD28-CD80	NNP
cord-261028-sxux2ujo	135	16	/	/	SYM
cord-261028-sxux2ujo	135	17	CD86	CD86	NNP
cord-261028-sxux2ujo	135	18	,	,	,
cord-261028-sxux2ujo	135	19	CD40LCD40	CD40LCD40	NNP
cord-261028-sxux2ujo	135	20	,	,	,
cord-261028-sxux2ujo	135	21	4	4	CD
cord-261028-sxux2ujo	135	22	-	-	SYM
cord-261028-sxux2ujo	135	23	1BBL/41BB	1bbl/41bb	CD
cord-261028-sxux2ujo	135	24	,	,	,
cord-261028-sxux2ujo	135	25	and	and	CC
cord-261028-sxux2ujo	135	26	SLAM	SLAM	NNP
cord-261028-sxux2ujo	135	27	-	-	HYPH
cord-261028-sxux2ujo	135	28	SLAM	slam	NN
cord-261028-sxux2ujo	135	29	associated	associated	JJ
cord-261028-sxux2ujo	135	30	protein	protein	NN
cord-261028-sxux2ujo	135	31	,	,	,
cord-261028-sxux2ujo	135	32	as	as	RB
cord-261028-sxux2ujo	135	33	well	well	RB
cord-261028-sxux2ujo	135	34	as	as	IN
cord-261028-sxux2ujo	135	35	molecules	molecule	NNS
cord-261028-sxux2ujo	135	36	that	that	WDT
cord-261028-sxux2ujo	135	37	provide	provide	VBP
cord-261028-sxux2ujo	135	38	negative	negative	JJ
cord-261028-sxux2ujo	135	39	signaling	signaling	NN
cord-261028-sxux2ujo	135	40	such	such	JJ
cord-261028-sxux2ujo	135	41	as	as	IN
cord-261028-sxux2ujo	135	42	PDL1	PDL1	NNP
cord-261028-sxux2ujo	135	43	and	and	CC
cord-261028-sxux2ujo	135	44	PDL2	PDL2	NNP
cord-261028-sxux2ujo	135	45	(	(	-LRB-
cord-261028-sxux2ujo	135	46	reviewed	review	VBN
cord-261028-sxux2ujo	135	47	in	in	IN
cord-261028-sxux2ujo	135	48	(	(	-LRB-
cord-261028-sxux2ujo	135	49	Chen	Chen	NNP
cord-261028-sxux2ujo	135	50	and	and	CC
cord-261028-sxux2ujo	135	51	Flies	Flies	NNP
cord-261028-sxux2ujo	135	52	,	,	,
cord-261028-sxux2ujo	135	53	2013	2013	CD
cord-261028-sxux2ujo	135	54	)	)	-RRB-
cord-261028-sxux2ujo	135	55	)	)	-RRB-
cord-261028-sxux2ujo	135	56	.	.	.
cord-261028-sxux2ujo	136	1	In	in	IN
cord-261028-sxux2ujo	136	2	the	the	DT
cord-261028-sxux2ujo	136	3	absence	absence	NN
cord-261028-sxux2ujo	136	4	of	of	IN
cord-261028-sxux2ujo	136	5	sufficient	sufficient	JJ
cord-261028-sxux2ujo	136	6	co	co	NN
cord-261028-sxux2ujo	136	7	-	-	JJ
cord-261028-sxux2ujo	136	8	stimulation	stimulation	NN
cord-261028-sxux2ujo	136	9	(	(	-LRB-
cord-261028-sxux2ujo	136	10	signal	signal	NN
cord-261028-sxux2ujo	136	11	2	2	CD
cord-261028-sxux2ujo	136	12	)	)	-RRB-
cord-261028-sxux2ujo	136	13	,	,	,
cord-261028-sxux2ujo	136	14	T	t	NN
cord-261028-sxux2ujo	136	15	cells	cell	NNS
cord-261028-sxux2ujo	136	16	become	become	VBP
cord-261028-sxux2ujo	136	17	anergic	anergic	NN
cord-261028-sxux2ujo	136	18	and	and	CC
cord-261028-sxux2ujo	136	19	fail	fail	VBP
cord-261028-sxux2ujo	136	20	to	to	TO
cord-261028-sxux2ujo	136	21	respond	respond	VB
cord-261028-sxux2ujo	136	22	upon	upon	IN
cord-261028-sxux2ujo	136	23	subsequent	subsequent	JJ
cord-261028-sxux2ujo	136	24	encounters	encounter	NNS
cord-261028-sxux2ujo	136	25	with	with	IN
cord-261028-sxux2ujo	136	26	their	-PRON-	PRP$
cord-261028-sxux2ujo	136	27	cognate	cognate	JJ
cord-261028-sxux2ujo	136	28	MHC/	mhc/	JJ
cord-261028-sxux2ujo	136	29	peptide	peptide	NN
cord-261028-sxux2ujo	136	30	complex	complex	NN
cord-261028-sxux2ujo	136	31	.	.	.
cord-261028-sxux2ujo	137	1	The	the	DT
cord-261028-sxux2ujo	137	2	third	third	JJ
cord-261028-sxux2ujo	137	3	signal	signal	NN
cord-261028-sxux2ujo	137	4	dictates	dictate	VBZ
cord-261028-sxux2ujo	137	5	the	the	DT
cord-261028-sxux2ujo	137	6	phenotype	phenotype	NN
cord-261028-sxux2ujo	137	7	and	and	CC
cord-261028-sxux2ujo	137	8	function	function	NN
cord-261028-sxux2ujo	137	9	of	of	IN
cord-261028-sxux2ujo	137	10	the	the	DT
cord-261028-sxux2ujo	137	11	primed	prime	VBN
cord-261028-sxux2ujo	137	12	T	t	NN
cord-261028-sxux2ujo	137	13	cell	cell	NN
cord-261028-sxux2ujo	137	14	,	,	,
cord-261028-sxux2ujo	137	15	and	and	CC
cord-261028-sxux2ujo	137	16	is	be	VBZ
cord-261028-sxux2ujo	137	17	mediated	mediate	VBN
cord-261028-sxux2ujo	137	18	by	by	IN
cord-261028-sxux2ujo	137	19	paracrine	paracrine	JJ
cord-261028-sxux2ujo	137	20	signaling	signaling	NN
cord-261028-sxux2ujo	137	21	by	by	IN
cord-261028-sxux2ujo	137	22	soluble	soluble	JJ
cord-261028-sxux2ujo	137	23	cytokines	cytokine	NNS
cord-261028-sxux2ujo	137	24	.	.	.
cord-261028-sxux2ujo	138	1	These	these	DT
cord-261028-sxux2ujo	138	2	can	can	MD
cord-261028-sxux2ujo	138	3	be	be	VB
cord-261028-sxux2ujo	138	4	pro	pro	JJ
cord-261028-sxux2ujo	138	5	-	-	JJ
cord-261028-sxux2ujo	138	6	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	138	7	(	(	-LRB-
cord-261028-sxux2ujo	138	8	e.g.	e.g.	JJ
cord-261028-sxux2ujo	138	9	IL-12	IL-12	NNP
cord-261028-sxux2ujo	138	10	and	and	CC
cord-261028-sxux2ujo	138	11	type	type	NN
cord-261028-sxux2ujo	138	12	I	-PRON-	PRP
cord-261028-sxux2ujo	138	13	IFNs	ifns	VBP
cord-261028-sxux2ujo	138	14	)	)	-RRB-
cord-261028-sxux2ujo	138	15	or	or	CC
cord-261028-sxux2ujo	138	16	anti	anti	JJ
cord-261028-sxux2ujo	138	17	-	-	JJ
cord-261028-sxux2ujo	138	18	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	138	19	(	(	-LRB-
cord-261028-sxux2ujo	138	20	e.g.	e.g.	RB
cord-261028-sxux2ujo	138	21	TFG	TFG	NNP
cord-261028-sxux2ujo	138	22	-	-	HYPH
cord-261028-sxux2ujo	138	23	β	β	NNP
cord-261028-sxux2ujo	138	24	and	and	CC
cord-261028-sxux2ujo	138	25	IL-10	IL-10	NNP
cord-261028-sxux2ujo	138	26	)	)	-RRB-
cord-261028-sxux2ujo	138	27	,	,	,
cord-261028-sxux2ujo	138	28	and	and	CC
cord-261028-sxux2ujo	138	29	help	help	VB
cord-261028-sxux2ujo	138	30	determine	determine	VB
cord-261028-sxux2ujo	138	31	expression	expression	NN
cord-261028-sxux2ujo	138	32	of	of	IN
cord-261028-sxux2ujo	138	33	chemokine	chemokine	NN
cord-261028-sxux2ujo	138	34	receptors	receptor	NNS
cord-261028-sxux2ujo	138	35	and	and	CC
cord-261028-sxux2ujo	138	36	integrins	integrin	NNS
cord-261028-sxux2ujo	138	37	that	that	WDT
cord-261028-sxux2ujo	138	38	facilitate	facilitate	VBP
cord-261028-sxux2ujo	138	39	T	t	NN
cord-261028-sxux2ujo	138	40	cell	cell	NN
cord-261028-sxux2ujo	138	41	homing	homing	NN
cord-261028-sxux2ujo	138	42	to	to	IN
cord-261028-sxux2ujo	138	43	specific	specific	JJ
cord-261028-sxux2ujo	138	44	target	target	NN
cord-261028-sxux2ujo	138	45	tissues	tissue	NNS
cord-261028-sxux2ujo	138	46	.	.	.
cord-261028-sxux2ujo	139	1	By	by	IN
cord-261028-sxux2ujo	139	2	providing	provide	VBG
cord-261028-sxux2ujo	139	3	these	these	DT
cord-261028-sxux2ujo	139	4	three	three	CD
cord-261028-sxux2ujo	139	5	signals	signal	NNS
cord-261028-sxux2ujo	139	6	,	,	,
cord-261028-sxux2ujo	139	7	TIDCs	tidc	NNS
cord-261028-sxux2ujo	139	8	induce	induce	VBP
cord-261028-sxux2ujo	139	9	tumor	tumor	NN
cord-261028-sxux2ujo	139	10	specific	specific	JJ
cord-261028-sxux2ujo	139	11	immunity	immunity	NN
cord-261028-sxux2ujo	139	12	mediated	mediate	VBN
cord-261028-sxux2ujo	139	13	by	by	IN
cord-261028-sxux2ujo	139	14	CD8	CD8	NNP
cord-261028-sxux2ujo	139	15	+	+	CC
cord-261028-sxux2ujo	139	16	T	T	NNP
cord-261028-sxux2ujo	139	17	cells	cell	NNS
cord-261028-sxux2ujo	139	18	,	,	,
cord-261028-sxux2ujo	139	19	which	which	WDT
cord-261028-sxux2ujo	139	20	can	can	MD
cord-261028-sxux2ujo	139	21	help	help	VB
cord-261028-sxux2ujo	139	22	eliminate	eliminate	VB
cord-261028-sxux2ujo	139	23	primary	primary	JJ
cord-261028-sxux2ujo	139	24	and	and	CC
cord-261028-sxux2ujo	139	25	metastatic	metastatic	JJ
cord-261028-sxux2ujo	139	26	tumors	tumor	NNS
cord-261028-sxux2ujo	139	27	,	,	,
cord-261028-sxux2ujo	139	28	and	and	CC
cord-261028-sxux2ujo	139	29	protect	protect	VB
cord-261028-sxux2ujo	139	30	against	against	IN
cord-261028-sxux2ujo	139	31	cancer	cancer	NN
cord-261028-sxux2ujo	139	32	recurrence	recurrence	NN
cord-261028-sxux2ujo	139	33	.	.	.
cord-261028-sxux2ujo	140	1	However	however	RB
cord-261028-sxux2ujo	140	2	,	,	,
cord-261028-sxux2ujo	140	3	TIDCs	tidc	NNS
cord-261028-sxux2ujo	140	4	often	often	RB
cord-261028-sxux2ujo	140	5	have	have	VBP
cord-261028-sxux2ujo	140	6	functional	functional	JJ
cord-261028-sxux2ujo	140	7	defects	defect	NNS
cord-261028-sxux2ujo	140	8	which	which	WDT
cord-261028-sxux2ujo	140	9	impair	impair	VBP
cord-261028-sxux2ujo	140	10	their	-PRON-	PRP$
cord-261028-sxux2ujo	140	11	ability	ability	NN
cord-261028-sxux2ujo	140	12	to	to	IN
cord-261028-sxux2ujo	140	13	prime	prime	JJ
cord-261028-sxux2ujo	140	14	anti	anti	JJ
cord-261028-sxux2ujo	140	15	-	-	JJ
cord-261028-sxux2ujo	140	16	tumor	tumor	JJ
cord-261028-sxux2ujo	140	17	immune	immune	JJ
cord-261028-sxux2ujo	140	18	responses	response	NNS
cord-261028-sxux2ujo	140	19	and	and	CC
cord-261028-sxux2ujo	140	20	can	can	MD
cord-261028-sxux2ujo	140	21	even	even	RB
cord-261028-sxux2ujo	140	22	suppress	suppress	VB
cord-261028-sxux2ujo	140	23	anti	anti	JJ
cord-261028-sxux2ujo	140	24	-	-	JJ
cord-261028-sxux2ujo	140	25	tumor	tumor	JJ
cord-261028-sxux2ujo	140	26	immunity	immunity	NN
cord-261028-sxux2ujo	140	27	and	and	CC
cord-261028-sxux2ujo	140	28	facilitate	facilitate	VB
cord-261028-sxux2ujo	140	29	tolerance	tolerance	NN
cord-261028-sxux2ujo	140	30	.	.	.
cord-261028-sxux2ujo	141	1	These	these	DT
cord-261028-sxux2ujo	141	2	functional	functional	JJ
cord-261028-sxux2ujo	141	3	deficits	deficit	NNS
cord-261028-sxux2ujo	141	4	range	range	VBP
cord-261028-sxux2ujo	141	5	from	from	IN
cord-261028-sxux2ujo	141	6	decreased	decrease	VBN
cord-261028-sxux2ujo	141	7	capacity	capacity	NN
cord-261028-sxux2ujo	141	8	for	for	IN
cord-261028-sxux2ujo	141	9	phagocytosis	phagocytosis	NN
cord-261028-sxux2ujo	141	10	,	,	,
cord-261028-sxux2ujo	141	11	reduced	reduced	JJ
cord-261028-sxux2ujo	141	12	antigen	antigen	NN
cord-261028-sxux2ujo	141	13	processing	processing	NN
cord-261028-sxux2ujo	141	14	capacity	capacity	NN
cord-261028-sxux2ujo	141	15	,	,	,
cord-261028-sxux2ujo	141	16	abnormal	abnormal	JJ
cord-261028-sxux2ujo	141	17	motility	motility	NN
cord-261028-sxux2ujo	141	18	and	and	CC
cord-261028-sxux2ujo	141	19	decreased	decrease	VBD
cord-261028-sxux2ujo	141	20	expression	expression	NN
cord-261028-sxux2ujo	141	21	of	of	IN
cord-261028-sxux2ujo	141	22	MHCI	MHCI	NNP
cord-261028-sxux2ujo	141	23	,	,	,
cord-261028-sxux2ujo	141	24	MHCII	MHCII	NNP
cord-261028-sxux2ujo	141	25	,	,	,
cord-261028-sxux2ujo	141	26	proinflammatory	proinflammatory	JJ
cord-261028-sxux2ujo	141	27	cytokines	cytokine	NNS
cord-261028-sxux2ujo	141	28	,	,	,
cord-261028-sxux2ujo	141	29	and	and	CC
cord-261028-sxux2ujo	141	30	co	co	JJ
cord-261028-sxux2ujo	141	31	-	-	JJ
cord-261028-sxux2ujo	141	32	stimulatory	stimulatory	JJ
cord-261028-sxux2ujo	141	33	molecules	molecule	NNS
cord-261028-sxux2ujo	141	34	such	such	JJ
cord-261028-sxux2ujo	141	35	as	as	IN
cord-261028-sxux2ujo	141	36	CD40	CD40	NNP
cord-261028-sxux2ujo	141	37	,	,	,
cord-261028-sxux2ujo	141	38	CD80	CD80	NNP
cord-261028-sxux2ujo	141	39	and	and	CC
cord-261028-sxux2ujo	141	40	CD86	CD86	NNP
cord-261028-sxux2ujo	141	41	(	(	-LRB-
cord-261028-sxux2ujo	141	42	Stoitzner	Stoitzner	NNP
cord-261028-sxux2ujo	141	43	et	et	NNP
cord-261028-sxux2ujo	141	44	al	al	NNP
cord-261028-sxux2ujo	141	45	.	.	NNP
cord-261028-sxux2ujo	141	46	,	,	,
cord-261028-sxux2ujo	141	47	2008	2008	CD
cord-261028-sxux2ujo	141	48	;	;	:
cord-261028-sxux2ujo	141	49	Diao	Diao	NNP
cord-261028-sxux2ujo	141	50	et	et	FW
cord-261028-sxux2ujo	141	51	al	al	NNP
cord-261028-sxux2ujo	141	52	.	.	.
cord-261028-sxux2ujo	142	1	,	,	,
cord-261028-sxux2ujo	142	2	2010	2010	CD
cord-261028-sxux2ujo	142	3	;	;	:
cord-261028-sxux2ujo	142	4	Diao	Diao	NNP
cord-261028-sxux2ujo	142	5	et	et	NNP
cord-261028-sxux2ujo	142	6	al	al	NNP
cord-261028-sxux2ujo	142	7	.	.	NNP
cord-261028-sxux2ujo	142	8	,	,	,
cord-261028-sxux2ujo	142	9	2011	2011	CD
cord-261028-sxux2ujo	142	10	;	;	:
cord-261028-sxux2ujo	143	1	Ataera	Ataera	NNP
cord-261028-sxux2ujo	143	2	et	et	NNP
cord-261028-sxux2ujo	143	3	al	al	NNP
cord-261028-sxux2ujo	143	4	.	.	NNP
cord-261028-sxux2ujo	143	5	,	,	,
cord-261028-sxux2ujo	143	6	2011	2011	CD
cord-261028-sxux2ujo	144	1	;	;	:
cord-261028-sxux2ujo	144	2	Chiba	Chiba	NNP
cord-261028-sxux2ujo	144	3	et	et	NNP
cord-261028-sxux2ujo	144	4	al	al	NNP
cord-261028-sxux2ujo	144	5	.	.	NNP
cord-261028-sxux2ujo	144	6	,	,	,
cord-261028-sxux2ujo	144	7	2012	2012	CD
cord-261028-sxux2ujo	144	8	)	)	-RRB-
cord-261028-sxux2ujo	144	9	.	.	.
cord-261028-sxux2ujo	145	1	TIDCs	tidc	NNS
cord-261028-sxux2ujo	145	2	also	also	RB
cord-261028-sxux2ujo	145	3	often	often	RB
cord-261028-sxux2ujo	145	4	have	have	VBP
cord-261028-sxux2ujo	145	5	increased	increase	VBN
cord-261028-sxux2ujo	145	6	expression	expression	NN
cord-261028-sxux2ujo	145	7	of	of	IN
cord-261028-sxux2ujo	145	8	inhibitory	inhibitory	JJ
cord-261028-sxux2ujo	145	9	mediators	mediator	NNS
cord-261028-sxux2ujo	145	10	,	,	,
cord-261028-sxux2ujo	145	11	including	include	VBG
cord-261028-sxux2ujo	145	12	the	the	DT
cord-261028-sxux2ujo	145	13	cytokines	cytokine	NNS
cord-261028-sxux2ujo	145	14	IL-10	IL-10	NNP
cord-261028-sxux2ujo	145	15	and	and	CC
cord-261028-sxux2ujo	145	16	TGF	TGF	NNP
cord-261028-sxux2ujo	145	17	-	-	HYPH
cord-261028-sxux2ujo	145	18	β	β	NNP
cord-261028-sxux2ujo	145	19	,	,	,
cord-261028-sxux2ujo	145	20	IDO	IDO	NNP
cord-261028-sxux2ujo	145	21	,	,	,
cord-261028-sxux2ujo	145	22	iNOS	iNOS	NNP
cord-261028-sxux2ujo	145	23	,	,	,
cord-261028-sxux2ujo	145	24	arginase	arginase	NNP
cord-261028-sxux2ujo	145	25	,	,	,
cord-261028-sxux2ujo	145	26	and	and	CC
cord-261028-sxux2ujo	145	27	the	the	DT
cord-261028-sxux2ujo	145	28	inhibitory	inhibitory	JJ
cord-261028-sxux2ujo	145	29	B7	b7	NN
cord-261028-sxux2ujo	145	30	family	family	NN
cord-261028-sxux2ujo	145	31	members	member	NNS
cord-261028-sxux2ujo	145	32	PDL1	PDL1	NNP
cord-261028-sxux2ujo	145	33	and	and	CC
cord-261028-sxux2ujo	145	34	PDL2	PDL2	NNP
cord-261028-sxux2ujo	145	35	.	.	.
cord-261028-sxux2ujo	146	1	One	one	CD
cord-261028-sxux2ujo	146	2	of	of	IN
cord-261028-sxux2ujo	146	3	the	the	DT
cord-261028-sxux2ujo	146	4	central	central	JJ
cord-261028-sxux2ujo	146	5	dogmas	dogma	NNS
cord-261028-sxux2ujo	146	6	of	of	IN
cord-261028-sxux2ujo	146	7	immunology	immunology	NN
cord-261028-sxux2ujo	146	8	is	be	VBZ
cord-261028-sxux2ujo	146	9	that	that	IN
cord-261028-sxux2ujo	146	10	endogenous	endogenous	JJ
cord-261028-sxux2ujo	146	11	antigens	antigen	NNS
cord-261028-sxux2ujo	146	12	are	be	VBP
cord-261028-sxux2ujo	146	13	efficiently	efficiently	RB
cord-261028-sxux2ujo	146	14	presented	present	VBN
cord-261028-sxux2ujo	146	15	in	in	IN
cord-261028-sxux2ujo	146	16	the	the	DT
cord-261028-sxux2ujo	146	17	context	context	NN
cord-261028-sxux2ujo	146	18	of	of	IN
cord-261028-sxux2ujo	146	19	MHCI	MHCI	NNP
cord-261028-sxux2ujo	146	20	and	and	CC
cord-261028-sxux2ujo	146	21	exogenous	exogenous	JJ
cord-261028-sxux2ujo	146	22	antigens	antigen	NNS
cord-261028-sxux2ujo	146	23	are	be	VBP
cord-261028-sxux2ujo	146	24	presented	present	VBN
cord-261028-sxux2ujo	146	25	in	in	IN
cord-261028-sxux2ujo	146	26	the	the	DT
cord-261028-sxux2ujo	146	27	context	context	NN
cord-261028-sxux2ujo	146	28	of	of	IN
cord-261028-sxux2ujo	146	29	MHCII	MHCII	NNP
cord-261028-sxux2ujo	146	30	.	.	.
cord-261028-sxux2ujo	147	1	Intriguingly	intriguingly	RB
cord-261028-sxux2ujo	147	2	,	,	,
cord-261028-sxux2ujo	147	3	some	some	DT
cord-261028-sxux2ujo	147	4	DCs	dc	NNS
cord-261028-sxux2ujo	147	5	are	be	VBP
cord-261028-sxux2ujo	147	6	able	able	JJ
cord-261028-sxux2ujo	147	7	to	to	TO
cord-261028-sxux2ujo	147	8	take	take	VB
cord-261028-sxux2ujo	147	9	up	up	RP
cord-261028-sxux2ujo	147	10	exogenous	exogenous	JJ
cord-261028-sxux2ujo	147	11	antigens	antigen	NNS
cord-261028-sxux2ujo	147	12	in	in	IN
cord-261028-sxux2ujo	147	13	certain	certain	JJ
cord-261028-sxux2ujo	147	14	contexts	context	NNS
cord-261028-sxux2ujo	147	15	(	(	-LRB-
cord-261028-sxux2ujo	147	16	e.g.	e.g.	JJ
cord-261028-sxux2ujo	147	17	cell	cell	NN
cord-261028-sxux2ujo	147	18	associated	associate	VBN
cord-261028-sxux2ujo	147	19	or	or	CC
cord-261028-sxux2ujo	147	20	particulate	particulate	NN
cord-261028-sxux2ujo	147	21	)	)	-RRB-
cord-261028-sxux2ujo	147	22	,	,	,
cord-261028-sxux2ujo	147	23	process	process	VB
cord-261028-sxux2ujo	147	24	them	-PRON-	PRP
cord-261028-sxux2ujo	147	25	,	,	,
cord-261028-sxux2ujo	147	26	load	load	VB
cord-261028-sxux2ujo	147	27	them	-PRON-	PRP
cord-261028-sxux2ujo	147	28	on	on	IN
cord-261028-sxux2ujo	147	29	MHCI	MHCI	NNP
cord-261028-sxux2ujo	147	30	,	,	,
cord-261028-sxux2ujo	147	31	and	and	CC
cord-261028-sxux2ujo	147	32	present	present	VB
cord-261028-sxux2ujo	147	33	them	-PRON-	PRP
cord-261028-sxux2ujo	147	34	on	on	IN
cord-261028-sxux2ujo	147	35	the	the	DT
cord-261028-sxux2ujo	147	36	cell	cell	NN
cord-261028-sxux2ujo	147	37	surface	surface	NN
cord-261028-sxux2ujo	147	38	through	through	IN
cord-261028-sxux2ujo	147	39	a	a	DT
cord-261028-sxux2ujo	147	40	process	process	NN
cord-261028-sxux2ujo	147	41	called	call	VBN
cord-261028-sxux2ujo	147	42	cross	cross	NN
cord-261028-sxux2ujo	147	43	-	-	NN
cord-261028-sxux2ujo	147	44	presentation	presentation	NN
cord-261028-sxux2ujo	147	45	(	(	-LRB-
cord-261028-sxux2ujo	147	46	Compeer	Compeer	NNP
cord-261028-sxux2ujo	147	47	et	et	NNP
cord-261028-sxux2ujo	147	48	al	al	NNP
cord-261028-sxux2ujo	147	49	.	.	NNP
cord-261028-sxux2ujo	147	50	,	,	,
cord-261028-sxux2ujo	147	51	2012	2012	CD
cord-261028-sxux2ujo	147	52	;	;	:
cord-261028-sxux2ujo	147	53	Burgdorf	Burgdorf	NNP
cord-261028-sxux2ujo	147	54	et	et	NNP
cord-261028-sxux2ujo	147	55	al	al	NNP
cord-261028-sxux2ujo	147	56	.	.	.
cord-261028-sxux2ujo	148	1	,	,	,
cord-261028-sxux2ujo	148	2	2008	2008	CD
cord-261028-sxux2ujo	148	3	;	;	:
cord-261028-sxux2ujo	148	4	Bevan	Bevan	NNP
cord-261028-sxux2ujo	148	5	,	,	,
cord-261028-sxux2ujo	148	6	1976	1976	CD
cord-261028-sxux2ujo	148	7	;	;	:
cord-261028-sxux2ujo	148	8	Bevan	Bevan	NNP
cord-261028-sxux2ujo	148	9	,	,	,
cord-261028-sxux2ujo	148	10	2006	2006	CD
cord-261028-sxux2ujo	148	11	)	)	-RRB-
cord-261028-sxux2ujo	148	12	.	.	.
cord-261028-sxux2ujo	149	1	This	this	DT
cord-261028-sxux2ujo	149	2	is	be	VBZ
cord-261028-sxux2ujo	149	3	the	the	DT
cord-261028-sxux2ujo	149	4	prevailing	prevail	VBG
cord-261028-sxux2ujo	149	5	mechanistic	mechanistic	JJ
cord-261028-sxux2ujo	149	6	hypothesis	hypothesis	NN
cord-261028-sxux2ujo	149	7	explaining	explain	VBG
cord-261028-sxux2ujo	149	8	how	how	WRB
cord-261028-sxux2ujo	149	9	TIDCs	tidcs	JJ
cord-261028-sxux2ujo	149	10	present	present	JJ
cord-261028-sxux2ujo	149	11	tumor	tumor	NN
cord-261028-sxux2ujo	149	12	antigens	antigen	NNS
cord-261028-sxux2ujo	149	13	in	in	IN
cord-261028-sxux2ujo	149	14	the	the	DT
cord-261028-sxux2ujo	149	15	context	context	NN
cord-261028-sxux2ujo	149	16	of	of	IN
cord-261028-sxux2ujo	149	17	MHCI	MHCI	NNP
cord-261028-sxux2ujo	149	18	,	,	,
cord-261028-sxux2ujo	149	19	providing	provide	VBG
cord-261028-sxux2ujo	149	20	Signal	Signal	NNP
cord-261028-sxux2ujo	149	21	1	1	CD
cord-261028-sxux2ujo	149	22	for	for	IN
cord-261028-sxux2ujo	149	23	priming	prime	VBG
cord-261028-sxux2ujo	149	24	naïve	naïve	JJ
cord-261028-sxux2ujo	149	25	CD8	CD8	NNP
cord-261028-sxux2ujo	149	26	+	+	CC
cord-261028-sxux2ujo	149	27	T	T	NNP
cord-261028-sxux2ujo	149	28	cells	cell	NNS
cord-261028-sxux2ujo	149	29	in	in	IN
cord-261028-sxux2ujo	149	30	the	the	DT
cord-261028-sxux2ujo	149	31	draining	drain	VBG
cord-261028-sxux2ujo	149	32	lymph	lymph	NN
cord-261028-sxux2ujo	149	33	nodes	node	NNS
cord-261028-sxux2ujo	149	34	.	.	.
cord-261028-sxux2ujo	150	1	Several	several	JJ
cord-261028-sxux2ujo	150	2	pathways	pathway	NNS
cord-261028-sxux2ujo	150	3	for	for	IN
cord-261028-sxux2ujo	150	4	cross	cross	NN
cord-261028-sxux2ujo	150	5	-	-	NN
cord-261028-sxux2ujo	150	6	presentation	presentation	NN
cord-261028-sxux2ujo	150	7	have	have	VBP
cord-261028-sxux2ujo	150	8	been	be	VBN
cord-261028-sxux2ujo	150	9	identified	identify	VBN
cord-261028-sxux2ujo	150	10	.	.	.
cord-261028-sxux2ujo	151	1	The	the	DT
cord-261028-sxux2ujo	151	2	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	151	3	pathway	pathway	NN
cord-261028-sxux2ujo	151	4	closely	closely	RB
cord-261028-sxux2ujo	151	5	resembles	resemble	VBZ
cord-261028-sxux2ujo	151	6	the	the	DT
cord-261028-sxux2ujo	151	7	classic	classic	JJ
cord-261028-sxux2ujo	151	8	pathway	pathway	NN
cord-261028-sxux2ujo	151	9	for	for	IN
cord-261028-sxux2ujo	151	10	presentation	presentation	NN
cord-261028-sxux2ujo	151	11	of	of	IN
cord-261028-sxux2ujo	151	12	endogenous	endogenous	JJ
cord-261028-sxux2ujo	151	13	peptides	peptide	NNS
cord-261028-sxux2ujo	151	14	on	on	IN
cord-261028-sxux2ujo	151	15	MHCI	MHCI	NNP
cord-261028-sxux2ujo	151	16	,	,	,
cord-261028-sxux2ujo	151	17	in	in	IN
cord-261028-sxux2ujo	151	18	which	which	WDT
cord-261028-sxux2ujo	151	19	endogenous	endogenous	JJ
cord-261028-sxux2ujo	151	20	proteins	protein	NNS
cord-261028-sxux2ujo	151	21	are	be	VBP
cord-261028-sxux2ujo	151	22	cleaved	cleave	VBN
cord-261028-sxux2ujo	151	23	by	by	IN
cord-261028-sxux2ujo	151	24	the	the	DT
cord-261028-sxux2ujo	151	25	proteasome	proteasome	NN
cord-261028-sxux2ujo	151	26	,	,	,
cord-261028-sxux2ujo	151	27	generating	generate	VBG
cord-261028-sxux2ujo	151	28	peptides	peptide	NNS
cord-261028-sxux2ujo	151	29	that	that	WDT
cord-261028-sxux2ujo	151	30	are	be	VBP
cord-261028-sxux2ujo	151	31	subsequently	subsequently	RB
cord-261028-sxux2ujo	151	32	translocated	translocate	VBN
cord-261028-sxux2ujo	151	33	into	into	IN
cord-261028-sxux2ujo	151	34	the	the	DT
cord-261028-sxux2ujo	151	35	ER	ER	NNP
cord-261028-sxux2ujo	151	36	lumen	lumen	NN
cord-261028-sxux2ujo	151	37	by	by	IN
cord-261028-sxux2ujo	151	38	TAP½	TAP½	NNP
cord-261028-sxux2ujo	151	39	for	for	IN
cord-261028-sxux2ujo	151	40	further	further	JJ
cord-261028-sxux2ujo	151	41	processing	processing	NN
cord-261028-sxux2ujo	151	42	and	and	CC
cord-261028-sxux2ujo	151	43	loading	load	VBG
cord-261028-sxux2ujo	151	44	onto	onto	IN
cord-261028-sxux2ujo	151	45	newly	newly	RB
cord-261028-sxux2ujo	151	46	synthesized	synthesize	VBN
cord-261028-sxux2ujo	151	47	MHCI	MHCI	NNP
cord-261028-sxux2ujo	151	48	molecules	molecule	NNS
cord-261028-sxux2ujo	151	49	(	(	-LRB-
cord-261028-sxux2ujo	151	50	Amigorena	Amigorena	NNP
cord-261028-sxux2ujo	151	51	and	and	CC
cord-261028-sxux2ujo	151	52	Savina	Savina	NNP
cord-261028-sxux2ujo	151	53	,	,	,
cord-261028-sxux2ujo	151	54	2010	2010	CD
cord-261028-sxux2ujo	151	55	;	;	:
cord-261028-sxux2ujo	151	56	Joffre	Joffre	NNP
cord-261028-sxux2ujo	151	57	et	et	FW
cord-261028-sxux2ujo	151	58	al	al	NNP
cord-261028-sxux2ujo	151	59	.	.	NNP
cord-261028-sxux2ujo	151	60	,	,	,
cord-261028-sxux2ujo	151	61	2012	2012	CD
cord-261028-sxux2ujo	151	62	)	)	-RRB-
cord-261028-sxux2ujo	151	63	.	.	.
cord-261028-sxux2ujo	152	1	Antigens	antigen	NNS
cord-261028-sxux2ujo	152	2	cross	cross	NN
cord-261028-sxux2ujo	152	3	-	-	VBN
cord-261028-sxux2ujo	152	4	presented	present	VBN
cord-261028-sxux2ujo	152	5	by	by	IN
cord-261028-sxux2ujo	152	6	this	this	DT
cord-261028-sxux2ujo	152	7	mechanism	mechanism	NN
cord-261028-sxux2ujo	152	8	are	be	VBP
cord-261028-sxux2ujo	152	9	taken	take	VBN
cord-261028-sxux2ujo	152	10	up	up	RP
cord-261028-sxux2ujo	152	11	by	by	IN
cord-261028-sxux2ujo	152	12	DCs	dc	NNS
cord-261028-sxux2ujo	152	13	where	where	WRB
cord-261028-sxux2ujo	152	14	they	-PRON-	PRP
cord-261028-sxux2ujo	152	15	escape	escape	VBP
cord-261028-sxux2ujo	152	16	endosomes	endosome	NNS
cord-261028-sxux2ujo	152	17	,	,	,
cord-261028-sxux2ujo	152	18	entering	enter	VBG
cord-261028-sxux2ujo	152	19	the	the	DT
cord-261028-sxux2ujo	152	20	cytosol	cytosol	NN
cord-261028-sxux2ujo	152	21	by	by	IN
cord-261028-sxux2ujo	152	22	an	an	DT
cord-261028-sxux2ujo	152	23	unknown	unknown	JJ
cord-261028-sxux2ujo	152	24	mechanism	mechanism	NN
cord-261028-sxux2ujo	152	25	where	where	WRB
cord-261028-sxux2ujo	152	26	they	-PRON-	PRP
cord-261028-sxux2ujo	152	27	are	be	VBP
cord-261028-sxux2ujo	152	28	then	then	RB
cord-261028-sxux2ujo	152	29	cleaved	cleave	VBN
cord-261028-sxux2ujo	152	30	by	by	IN
cord-261028-sxux2ujo	152	31	the	the	DT
cord-261028-sxux2ujo	152	32	proteasome	proteasome	NN
cord-261028-sxux2ujo	152	33	.	.	.
cord-261028-sxux2ujo	153	1	In	in	IN
cord-261028-sxux2ujo	153	2	contrast	contrast	NN
cord-261028-sxux2ujo	153	3	to	to	IN
cord-261028-sxux2ujo	153	4	the	the	DT
cord-261028-sxux2ujo	153	5	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	153	6	pathway	pathway	NN
cord-261028-sxux2ujo	153	7	,	,	,
cord-261028-sxux2ujo	153	8	cross	cross	NN
cord-261028-sxux2ujo	153	9	-	-	NN
cord-261028-sxux2ujo	153	10	presentation	presentation	NN
cord-261028-sxux2ujo	153	11	through	through	IN
cord-261028-sxux2ujo	153	12	the	the	DT
cord-261028-sxux2ujo	153	13	vacuolar	vacuolar	NNP
cord-261028-sxux2ujo	153	14	pathway	pathway	NN
cord-261028-sxux2ujo	153	15	does	do	VBZ
cord-261028-sxux2ujo	153	16	not	not	RB
cord-261028-sxux2ujo	153	17	require	require	VB
cord-261028-sxux2ujo	153	18	TAP½	TAP½	NNP
cord-261028-sxux2ujo	153	19	and	and	CC
cord-261028-sxux2ujo	153	20	seems	seem	VBZ
cord-261028-sxux2ujo	153	21	to	to	TO
cord-261028-sxux2ujo	153	22	result	result	VB
cord-261028-sxux2ujo	153	23	from	from	IN
cord-261028-sxux2ujo	153	24	antigen	antigen	NN
cord-261028-sxux2ujo	153	25	processing	processing	NN
cord-261028-sxux2ujo	153	26	and	and	CC
cord-261028-sxux2ujo	153	27	loading	loading	NN
cord-261028-sxux2ujo	153	28	of	of	IN
cord-261028-sxux2ujo	153	29	peptide	peptide	NN
cord-261028-sxux2ujo	153	30	antigens	antigen	NNS
cord-261028-sxux2ujo	153	31	onto	onto	IN
cord-261028-sxux2ujo	153	32	MHCI	MHCI	NNP
cord-261028-sxux2ujo	153	33	in	in	IN
cord-261028-sxux2ujo	153	34	the	the	DT
cord-261028-sxux2ujo	153	35	endocytic	endocytic	JJ
cord-261028-sxux2ujo	153	36	compartments	compartment	NNS
cord-261028-sxux2ujo	153	37	.	.	.
cord-261028-sxux2ujo	154	1	A	a	DT
cord-261028-sxux2ujo	154	2	third	third	JJ
cord-261028-sxux2ujo	154	3	mechanism	mechanism	NN
cord-261028-sxux2ujo	154	4	involving	involve	VBG
cord-261028-sxux2ujo	154	5	phagosome	phagosome	NNP
cord-261028-sxux2ujo	154	6	-	-	HYPH
cord-261028-sxux2ujo	154	7	ER	er	NN
cord-261028-sxux2ujo	154	8	fusion	fusion	NN
cord-261028-sxux2ujo	154	9	has	have	VBZ
cord-261028-sxux2ujo	154	10	also	also	RB
cord-261028-sxux2ujo	154	11	been	be	VBN
cord-261028-sxux2ujo	154	12	demonstrated	demonstrate	VBN
cord-261028-sxux2ujo	154	13	in	in	IN
cord-261028-sxux2ujo	154	14	DCs	dc	NNS
cord-261028-sxux2ujo	154	15	(	(	-LRB-
cord-261028-sxux2ujo	154	16	Guermonprez	Guermonprez	NNP
cord-261028-sxux2ujo	154	17	et	et	FW
cord-261028-sxux2ujo	154	18	al	al	NNP
cord-261028-sxux2ujo	154	19	.	.	NNP
cord-261028-sxux2ujo	154	20	,	,	,
cord-261028-sxux2ujo	154	21	2003	2003	CD
cord-261028-sxux2ujo	154	22	;	;	:
cord-261028-sxux2ujo	154	23	Ackerman	Ackerman	NNP
cord-261028-sxux2ujo	154	24	et	et	NNP
cord-261028-sxux2ujo	154	25	al	al	NNP
cord-261028-sxux2ujo	154	26	.	.	NNP
cord-261028-sxux2ujo	154	27	,	,	,
cord-261028-sxux2ujo	154	28	2003	2003	CD
cord-261028-sxux2ujo	154	29	;	;	:
cord-261028-sxux2ujo	154	30	Houde	Houde	NNP
cord-261028-sxux2ujo	154	31	et	et	NNP
cord-261028-sxux2ujo	154	32	al	al	NNP
cord-261028-sxux2ujo	154	33	.	.	NNP
cord-261028-sxux2ujo	154	34	,	,	,
cord-261028-sxux2ujo	154	35	2003	2003	CD
cord-261028-sxux2ujo	154	36	)	)	-RRB-
cord-261028-sxux2ujo	154	37	.	.	.
cord-261028-sxux2ujo	155	1	This	this	DT
cord-261028-sxux2ujo	155	2	is	be	VBZ
cord-261028-sxux2ujo	155	3	a	a	DT
cord-261028-sxux2ujo	155	4	sort	sort	NN
cord-261028-sxux2ujo	155	5	of	of	IN
cord-261028-sxux2ujo	155	6	hybrid	hybrid	NN
cord-261028-sxux2ujo	155	7	between	between	IN
cord-261028-sxux2ujo	155	8	the	the	DT
cord-261028-sxux2ujo	155	9	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	155	10	and	and	CC
cord-261028-sxux2ujo	155	11	vacuolar	vacuolar	JJ
cord-261028-sxux2ujo	155	12	pathways	pathway	NNS
cord-261028-sxux2ujo	155	13	in	in	IN
cord-261028-sxux2ujo	155	14	which	which	WDT
cord-261028-sxux2ujo	155	15	phagosomes	phagosome	NNS
cord-261028-sxux2ujo	155	16	combine	combine	VBP
cord-261028-sxux2ujo	155	17	with	with	IN
cord-261028-sxux2ujo	155	18	the	the	DT
cord-261028-sxux2ujo	155	19	ER	ER	NNP
cord-261028-sxux2ujo	155	20	and	and	CC
cord-261028-sxux2ujo	155	21	acquire	acquire	VB
cord-261028-sxux2ujo	155	22	antigen	antigen	NN
cord-261028-sxux2ujo	155	23	processing	processing	NN
cord-261028-sxux2ujo	155	24	proteins	protein	NNS
cord-261028-sxux2ujo	155	25	such	such	JJ
cord-261028-sxux2ujo	155	26	as	as	IN
cord-261028-sxux2ujo	155	27	MHCI	MHCI	NNP
cord-261028-sxux2ujo	155	28	and	and	CC
cord-261028-sxux2ujo	155	29	TAP½.	TAP½.	NNP
cord-261028-sxux2ujo	155	30	Antigens	antigen	NNS
cord-261028-sxux2ujo	155	31	escape	escape	VB
cord-261028-sxux2ujo	155	32	these	these	DT
cord-261028-sxux2ujo	155	33	phagosomes	phagosome	NNS
cord-261028-sxux2ujo	155	34	where	where	WRB
cord-261028-sxux2ujo	155	35	they	-PRON-	PRP
cord-261028-sxux2ujo	155	36	are	be	VBP
cord-261028-sxux2ujo	155	37	cleaved	cleave	VBN
cord-261028-sxux2ujo	155	38	by	by	IN
cord-261028-sxux2ujo	155	39	the	the	DT
cord-261028-sxux2ujo	155	40	proteasome	proteasome	NN
cord-261028-sxux2ujo	155	41	,	,	,
cord-261028-sxux2ujo	155	42	generating	generate	VBG
cord-261028-sxux2ujo	155	43	peptides	peptide	NNS
cord-261028-sxux2ujo	155	44	that	that	WDT
cord-261028-sxux2ujo	155	45	are	be	VBP
cord-261028-sxux2ujo	155	46	transported	transport	VBN
cord-261028-sxux2ujo	155	47	back	back	RB
cord-261028-sxux2ujo	155	48	into	into	IN
cord-261028-sxux2ujo	155	49	the	the	DT
cord-261028-sxux2ujo	155	50	ER	ER	NNP
cord-261028-sxux2ujo	155	51	-	-	HYPH
cord-261028-sxux2ujo	155	52	phagosome	phagosome	NNP
cord-261028-sxux2ujo	155	53	where	where	WRB
cord-261028-sxux2ujo	155	54	they	-PRON-	PRP
cord-261028-sxux2ujo	155	55	are	be	VBP
cord-261028-sxux2ujo	155	56	further	further	RB
cord-261028-sxux2ujo	155	57	processed	process	VBN
cord-261028-sxux2ujo	155	58	and	and	CC
cord-261028-sxux2ujo	155	59	loaded	load	VBN
cord-261028-sxux2ujo	155	60	on	on	IN
cord-261028-sxux2ujo	155	61	MHCI	MHCI	NNP
cord-261028-sxux2ujo	155	62	.	.	.
cord-261028-sxux2ujo	156	1	shown	show	VBN
cord-261028-sxux2ujo	156	2	to	to	TO
cord-261028-sxux2ujo	156	3	be	be	VB
cord-261028-sxux2ujo	156	4	more	more	RBR
cord-261028-sxux2ujo	156	5	capable	capable	JJ
cord-261028-sxux2ujo	156	6	to	to	TO
cord-261028-sxux2ujo	156	7	cross	cross	VB
cord-261028-sxux2ujo	156	8	-	-	JJ
cord-261028-sxux2ujo	156	9	present	present	JJ
cord-261028-sxux2ujo	156	10	cell	cell	NN
cord-261028-sxux2ujo	156	11	-	-	HYPH
cord-261028-sxux2ujo	156	12	associated	associate	VBN
cord-261028-sxux2ujo	156	13	antigens	antigen	NNS
cord-261028-sxux2ujo	156	14	than	than	IN
cord-261028-sxux2ujo	156	15	other	other	JJ
cord-261028-sxux2ujo	156	16	populations	population	NNS
cord-261028-sxux2ujo	156	17	.	.	.
cord-261028-sxux2ujo	157	1	While	while	IN
cord-261028-sxux2ujo	157	2	most	most	JJS
cord-261028-sxux2ujo	157	3	DC	DC	NNP
cord-261028-sxux2ujo	157	4	populations	population	NNS
cord-261028-sxux2ujo	157	5	can	can	MD
cord-261028-sxux2ujo	157	6	cross	cross	VB
cord-261028-sxux2ujo	157	7	-	-	JJ
cord-261028-sxux2ujo	157	8	present	present	JJ
cord-261028-sxux2ujo	157	9	materials	material	NNS
cord-261028-sxux2ujo	157	10	under	under	IN
cord-261028-sxux2ujo	157	11	targeted	target	VBN
cord-261028-sxux2ujo	157	12	experimental	experimental	JJ
cord-261028-sxux2ujo	157	13	conditions	condition	NNS
cord-261028-sxux2ujo	157	14	,	,	,
cord-261028-sxux2ujo	157	15	optimal	optimal	JJ
cord-261028-sxux2ujo	157	16	presentation	presentation	NN
cord-261028-sxux2ujo	157	17	of	of	IN
cord-261028-sxux2ujo	157	18	(	(	-LRB-
cord-261028-sxux2ujo	157	19	tumor	tumor	NN
cord-261028-sxux2ujo	157	20	)	)	-RRB-
cord-261028-sxux2ujo	157	21	cell	cell	NN
cord-261028-sxux2ujo	157	22	-	-	HYPH
cord-261028-sxux2ujo	157	23	associated	associate	VBN
cord-261028-sxux2ujo	157	24	antigens	antigen	NNS
cord-261028-sxux2ujo	157	25	seems	seem	VBZ
cord-261028-sxux2ujo	157	26	to	to	TO
cord-261028-sxux2ujo	157	27	be	be	VB
cord-261028-sxux2ujo	157	28	limited	limit	VBN
cord-261028-sxux2ujo	157	29	to	to	IN
cord-261028-sxux2ujo	157	30	a	a	DT
cord-261028-sxux2ujo	157	31	few	few	JJ
cord-261028-sxux2ujo	157	32	populations	population	NNS
cord-261028-sxux2ujo	157	33	of	of	IN
cord-261028-sxux2ujo	157	34	cDC1s	cDC1s	NNP
cord-261028-sxux2ujo	158	1	(	(	-LRB-
cord-261028-sxux2ujo	158	2	Faure	Faure	NNP
cord-261028-sxux2ujo	158	3	et	et	NNP
cord-261028-sxux2ujo	158	4	al	al	NNP
cord-261028-sxux2ujo	158	5	.	.	NNP
cord-261028-sxux2ujo	158	6	,	,	,
cord-261028-sxux2ujo	158	7	2009	2009	CD
cord-261028-sxux2ujo	158	8	;	;	:
cord-261028-sxux2ujo	158	9	Nierkens	Nierkens	NNP
cord-261028-sxux2ujo	158	10	et	et	FW
cord-261028-sxux2ujo	158	11	al	al	NNP
cord-261028-sxux2ujo	158	12	.	.	NNP
cord-261028-sxux2ujo	158	13	,	,	,
cord-261028-sxux2ujo	158	14	2013	2013	CD
cord-261028-sxux2ujo	158	15	;	;	:
cord-261028-sxux2ujo	158	16	Thacker	Thacker	NNP
cord-261028-sxux2ujo	158	17	and	and	CC
cord-261028-sxux2ujo	158	18	Janssen	Janssen	NNP
cord-261028-sxux2ujo	158	19	,	,	,
cord-261028-sxux2ujo	158	20	2012	2012	CD
cord-261028-sxux2ujo	158	21	)	)	-RRB-
cord-261028-sxux2ujo	158	22	.	.	.
cord-261028-sxux2ujo	159	1	Several	several	JJ
cord-261028-sxux2ujo	159	2	mechanisms	mechanism	NNS
cord-261028-sxux2ujo	159	3	have	have	VBP
cord-261028-sxux2ujo	159	4	been	be	VBN
cord-261028-sxux2ujo	159	5	uncovered	uncover	VBN
cord-261028-sxux2ujo	159	6	that	that	WDT
cord-261028-sxux2ujo	159	7	explain	explain	VBP
cord-261028-sxux2ujo	159	8	the	the	DT
cord-261028-sxux2ujo	159	9	improved	improved	JJ
cord-261028-sxux2ujo	159	10	capacity	capacity	NN
cord-261028-sxux2ujo	159	11	for	for	IN
cord-261028-sxux2ujo	159	12	cross	cross	NN
cord-261028-sxux2ujo	159	13	-	-	NN
cord-261028-sxux2ujo	159	14	presentation	presentation	NN
cord-261028-sxux2ujo	159	15	of	of	IN
cord-261028-sxux2ujo	159	16	cell	cell	NN
cord-261028-sxux2ujo	159	17	-	-	HYPH
cord-261028-sxux2ujo	159	18	associated	associate	VBN
cord-261028-sxux2ujo	159	19	antigens	antigen	NNS
cord-261028-sxux2ujo	159	20	by	by	IN
cord-261028-sxux2ujo	159	21	these	these	DT
cord-261028-sxux2ujo	159	22	cDC1s	cdc1	NNS
cord-261028-sxux2ujo	159	23	.	.	.
cord-261028-sxux2ujo	160	1	These	these	DT
cord-261028-sxux2ujo	160	2	include	include	VBP
cord-261028-sxux2ujo	160	3	increased	increase	VBN
cord-261028-sxux2ujo	160	4	capacity	capacity	NN
cord-261028-sxux2ujo	160	5	to	to	TO
cord-261028-sxux2ujo	160	6	take	take	VB
cord-261028-sxux2ujo	160	7	up	up	RP
cord-261028-sxux2ujo	160	8	cell	cell	NN
cord-261028-sxux2ujo	160	9	-	-	HYPH
cord-261028-sxux2ujo	160	10	associated	associate	VBN
cord-261028-sxux2ujo	160	11	materials	material	NNS
cord-261028-sxux2ujo	160	12	,	,	,
cord-261028-sxux2ujo	160	13	alterations	alteration	NNS
cord-261028-sxux2ujo	160	14	in	in	IN
cord-261028-sxux2ujo	160	15	trafficking	trafficking	NN
cord-261028-sxux2ujo	160	16	and	and	CC
cord-261028-sxux2ujo	160	17	acidification	acidification	NN
cord-261028-sxux2ujo	160	18	of	of	IN
cord-261028-sxux2ujo	160	19	endocytosed	endocytosed	JJ
cord-261028-sxux2ujo	160	20	materials	material	NNS
cord-261028-sxux2ujo	160	21	,	,	,
cord-261028-sxux2ujo	160	22	and	and	CC
cord-261028-sxux2ujo	160	23	alterations	alteration	NNS
cord-261028-sxux2ujo	160	24	in	in	IN
cord-261028-sxux2ujo	160	25	expression	expression	NN
cord-261028-sxux2ujo	160	26	of	of	IN
cord-261028-sxux2ujo	160	27	components	component	NNS
cord-261028-sxux2ujo	160	28	of	of	IN
cord-261028-sxux2ujo	160	29	the	the	DT
cord-261028-sxux2ujo	160	30	antigen	antigen	NN
cord-261028-sxux2ujo	160	31	processing	process	VBG
cord-261028-sxux2ujo	160	32	machinery	machinery	NN
cord-261028-sxux2ujo	160	33	or	or	CC
cord-261028-sxux2ujo	160	34	its	-PRON-	PRP$
cord-261028-sxux2ujo	160	35	intracellular	intracellular	JJ
cord-261028-sxux2ujo	160	36	trafficking	trafficking	NN
cord-261028-sxux2ujo	160	37	.	.	.
cord-261028-sxux2ujo	161	1	DCs	dc	NNS
cord-261028-sxux2ujo	161	2	are	be	VBP
cord-261028-sxux2ujo	161	3	able	able	JJ
cord-261028-sxux2ujo	161	4	to	to	TO
cord-261028-sxux2ujo	161	5	recognize	recognize	VB
cord-261028-sxux2ujo	161	6	and	and	CC
cord-261028-sxux2ujo	162	1	endocytose	endocytose	NN
cord-261028-sxux2ujo	162	2	dying	die	VBG
cord-261028-sxux2ujo	162	3	cells	cell	NNS
cord-261028-sxux2ujo	162	4	by	by	IN
cord-261028-sxux2ujo	162	5	means	mean	NNS
cord-261028-sxux2ujo	162	6	of	of	IN
cord-261028-sxux2ujo	162	7	receptors	receptor	NNS
cord-261028-sxux2ujo	162	8	that	that	WDT
cord-261028-sxux2ujo	162	9	discriminate	discriminate	VBP
cord-261028-sxux2ujo	162	10	between	between	IN
cord-261028-sxux2ujo	162	11	"	"	``
cord-261028-sxux2ujo	162	12	do	do	VB
cord-261028-sxux2ujo	162	13	n't	not	RB
cord-261028-sxux2ujo	162	14	eat	eat	VB
cord-261028-sxux2ujo	162	15	me	-PRON-	PRP
cord-261028-sxux2ujo	162	16	"	"	''
cord-261028-sxux2ujo	162	17	signals	signal	NNS
cord-261028-sxux2ujo	162	18	provided	provide	VBN
cord-261028-sxux2ujo	162	19	by	by	IN
cord-261028-sxux2ujo	162	20	healthy	healthy	JJ
cord-261028-sxux2ujo	162	21	cells	cell	NNS
cord-261028-sxux2ujo	162	22	(	(	-LRB-
cord-261028-sxux2ujo	162	23	including	include	VBG
cord-261028-sxux2ujo	162	24	CD47	CD47	NNP
cord-261028-sxux2ujo	162	25	that	that	WDT
cord-261028-sxux2ujo	162	26	is	be	VBZ
cord-261028-sxux2ujo	162	27	recognized	recognize	VBN
cord-261028-sxux2ujo	162	28	by	by	IN
cord-261028-sxux2ujo	162	29	CD172	cd172	NN
cord-261028-sxux2ujo	162	30	and	and	CC
cord-261028-sxux2ujo	162	31	CD31	CD31	NNP
cord-261028-sxux2ujo	162	32	)	)	-RRB-
cord-261028-sxux2ujo	162	33	,	,	,
cord-261028-sxux2ujo	162	34	"	"	``
cord-261028-sxux2ujo	162	35	find	find	VB
cord-261028-sxux2ujo	162	36	-	-	HYPH
cord-261028-sxux2ujo	162	37	me	-PRON-	PRP
cord-261028-sxux2ujo	162	38	"	"	''
cord-261028-sxux2ujo	162	39	and	and	CC
cord-261028-sxux2ujo	162	40	"	"	``
cord-261028-sxux2ujo	162	41	eat	eat	VB
cord-261028-sxux2ujo	162	42	-	-	HYPH
cord-261028-sxux2ujo	162	43	me	-PRON-	PRP
cord-261028-sxux2ujo	162	44	"	"	''
cord-261028-sxux2ujo	162	45	signals	signal	NNS
cord-261028-sxux2ujo	162	46	provided	provide	VBN
cord-261028-sxux2ujo	162	47	by	by	IN
cord-261028-sxux2ujo	162	48	specific	specific	JJ
cord-261028-sxux2ujo	162	49	entities	entity	NNS
cord-261028-sxux2ujo	162	50	on	on	IN
cord-261028-sxux2ujo	162	51	dead	dead	JJ
cord-261028-sxux2ujo	162	52	and	and	CC
cord-261028-sxux2ujo	162	53	dying	die	VBG
cord-261028-sxux2ujo	162	54	cells	cell	NNS
cord-261028-sxux2ujo	162	55	(	(	-LRB-
cord-261028-sxux2ujo	162	56	reviewed	review	VBN
cord-261028-sxux2ujo	162	57	in	in	IN
cord-261028-sxux2ujo	162	58	(	(	-LRB-
cord-261028-sxux2ujo	162	59	Medina	Medina	NNP
cord-261028-sxux2ujo	162	60	and	and	CC
cord-261028-sxux2ujo	162	61	Ravichandran	Ravichandran	NNP
cord-261028-sxux2ujo	162	62	,	,	,
cord-261028-sxux2ujo	162	63	2016	2016	CD
cord-261028-sxux2ujo	162	64	;	;	:
cord-261028-sxux2ujo	162	65	Elliott	Elliott	NNP
cord-261028-sxux2ujo	162	66	and	and	CC
cord-261028-sxux2ujo	162	67	Ravichandran	Ravichandran	NNP
cord-261028-sxux2ujo	162	68	,	,	,
cord-261028-sxux2ujo	162	69	2016	2016	CD
cord-261028-sxux2ujo	162	70	;	;	:
cord-261028-sxux2ujo	162	71	Bratton	Bratton	NNP
cord-261028-sxux2ujo	162	72	and	and	CC
cord-261028-sxux2ujo	162	73	Henson	Henson	NNP
cord-261028-sxux2ujo	162	74	,	,	,
cord-261028-sxux2ujo	162	75	2008	2008	CD
cord-261028-sxux2ujo	162	76	;	;	:
cord-261028-sxux2ujo	162	77	Liu	Liu	NNP
cord-261028-sxux2ujo	162	78	et	et	NNP
cord-261028-sxux2ujo	162	79	al	al	NNP
cord-261028-sxux2ujo	162	80	.	.	NNP
cord-261028-sxux2ujo	162	81	,	,	,
cord-261028-sxux2ujo	162	82	2015	2015	CD
cord-261028-sxux2ujo	162	83	)	)	-RRB-
cord-261028-sxux2ujo	162	84	)	)	-RRB-
cord-261028-sxux2ujo	162	85	.	.	.
cord-261028-sxux2ujo	163	1	The	the	DT
cord-261028-sxux2ujo	163	2	"	"	``
cord-261028-sxux2ujo	163	3	find	find	NN
cord-261028-sxux2ujo	163	4	-	-	HYPH
cord-261028-sxux2ujo	163	5	me	-PRON-	PRP
cord-261028-sxux2ujo	163	6	"	"	''
cord-261028-sxux2ujo	163	7	signals	signal	NNS
cord-261028-sxux2ujo	163	8	have	have	VBP
cord-261028-sxux2ujo	163	9	been	be	VBN
cord-261028-sxux2ujo	163	10	suggested	suggest	VBN
cord-261028-sxux2ujo	163	11	to	to	TO
cord-261028-sxux2ujo	163	12	include	include	VB
cord-261028-sxux2ujo	163	13	ATP	ATP	NNP
cord-261028-sxux2ujo	163	14	,	,	,
cord-261028-sxux2ujo	163	15	uridine	uridine	NN
cord-261028-sxux2ujo	163	16	5'triphosphate	5'triphosphate	CD
cord-261028-sxux2ujo	163	17	(	(	-LRB-
cord-261028-sxux2ujo	163	18	UTP	UTP	NNP
cord-261028-sxux2ujo	163	19	)	)	-RRB-
cord-261028-sxux2ujo	163	20	,	,	,
cord-261028-sxux2ujo	163	21	sphingosine	sphingosine	NNP
cord-261028-sxux2ujo	163	22	1-phosphate	1-phosphate	NNP
cord-261028-sxux2ujo	163	23	(	(	-LRB-
cord-261028-sxux2ujo	163	24	S1P	s1p	NN
cord-261028-sxux2ujo	163	25	)	)	-RRB-
cord-261028-sxux2ujo	163	26	,	,	,
cord-261028-sxux2ujo	163	27	lysophosphatidyl	lysophosphatidyl	NNP
cord-261028-sxux2ujo	163	28	choline	choline	NN
cord-261028-sxux2ujo	163	29	,	,	,
cord-261028-sxux2ujo	163	30	and	and	CC
cord-261028-sxux2ujo	163	31	fractaline	fractaline	NN
cord-261028-sxux2ujo	163	32	/	/	SYM
cord-261028-sxux2ujo	163	33	CX3CL1	CX3CL1	NNP
cord-261028-sxux2ujo	163	34	.	.	.
cord-261028-sxux2ujo	164	1	Depending	depend	VBG
cord-261028-sxux2ujo	164	2	on	on	IN
cord-261028-sxux2ujo	164	3	the	the	DT
cord-261028-sxux2ujo	164	4	manner	manner	NN
cord-261028-sxux2ujo	164	5	of	of	IN
cord-261028-sxux2ujo	164	6	cell	cell	NN
cord-261028-sxux2ujo	164	7	death	death	NN
cord-261028-sxux2ujo	164	8	,	,	,
cord-261028-sxux2ujo	164	9	the	the	DT
cord-261028-sxux2ujo	164	10	dying	die	VBG
cord-261028-sxux2ujo	164	11	cells	cell	NNS
cord-261028-sxux2ujo	164	12	will	will	MD
cord-261028-sxux2ujo	164	13	expose	expose	VB
cord-261028-sxux2ujo	164	14	"	"	``
cord-261028-sxux2ujo	164	15	eatme	eatme	JJ
cord-261028-sxux2ujo	164	16	"	"	''
cord-261028-sxux2ujo	164	17	signals	signal	NNS
cord-261028-sxux2ujo	164	18	on	on	IN
cord-261028-sxux2ujo	164	19	a	a	DT
cord-261028-sxux2ujo	164	20	continuum	continuum	NN
cord-261028-sxux2ujo	164	21	of	of	IN
cord-261028-sxux2ujo	164	22	dynamic	dynamic	JJ
cord-261028-sxux2ujo	164	23	and	and	CC
cord-261028-sxux2ujo	164	24	distinct	distinct	JJ
cord-261028-sxux2ujo	164	25	cellular	cellular	JJ
cord-261028-sxux2ujo	164	26	changes	change	NNS
cord-261028-sxux2ujo	164	27	.	.	.
cord-261028-sxux2ujo	165	1	Phosphatidyl	Phosphatidyl	NNP
cord-261028-sxux2ujo	165	2	serine	serine	NN
cord-261028-sxux2ujo	165	3	(	(	-LRB-
cord-261028-sxux2ujo	165	4	PtdSer	PtdSer	NNP
cord-261028-sxux2ujo	165	5	)	)	-RRB-
cord-261028-sxux2ujo	165	6	,	,	,
cord-261028-sxux2ujo	165	7	an	an	DT
cord-261028-sxux2ujo	165	8	early	early	JJ
cord-261028-sxux2ujo	165	9	"	"	``
cord-261028-sxux2ujo	165	10	eat	eat	VB
cord-261028-sxux2ujo	165	11	-	-	HYPH
cord-261028-sxux2ujo	165	12	me	-PRON-	PRP
cord-261028-sxux2ujo	165	13	"	"	''
cord-261028-sxux2ujo	165	14	signal	signal	NN
cord-261028-sxux2ujo	165	15	,	,	,
cord-261028-sxux2ujo	165	16	can	can	MD
cord-261028-sxux2ujo	165	17	be	be	VB
cord-261028-sxux2ujo	165	18	bound	bind	VBN
cord-261028-sxux2ujo	165	19	directly	directly	RB
cord-261028-sxux2ujo	165	20	by	by	IN
cord-261028-sxux2ujo	165	21	receptors	receptor	NNS
cord-261028-sxux2ujo	165	22	such	such	JJ
cord-261028-sxux2ujo	165	23	as	as	IN
cord-261028-sxux2ujo	165	24	TIM-1	TIM-1	NNP
cord-261028-sxux2ujo	165	25	,	,	,
cord-261028-sxux2ujo	165	26	TIM-3	tim-3	JJ
cord-261028-sxux2ujo	165	27	,	,	,
cord-261028-sxux2ujo	165	28	TIM-4	TIM-4	NNP
cord-261028-sxux2ujo	165	29	and	and	CC
cord-261028-sxux2ujo	165	30	BAI	BAI	NNP
cord-261028-sxux2ujo	165	31	or	or	CC
cord-261028-sxux2ujo	165	32	indirectly	indirectly	RB
cord-261028-sxux2ujo	165	33	,	,	,
cord-261028-sxux2ujo	165	34	using	use	VBG
cord-261028-sxux2ujo	165	35	bridging	bridge	VBG
cord-261028-sxux2ujo	165	36	molecules	molecule	NNS
cord-261028-sxux2ujo	166	1	MFGE8	MFGE8	NNS
cord-261028-sxux2ujo	166	2	,	,	,
cord-261028-sxux2ujo	167	1	Gas6	gas6	NN
cord-261028-sxux2ujo	167	2	,	,	,
cord-261028-sxux2ujo	167	3	protein	protein	NN
cord-261028-sxux2ujo	167	4	S.	S.	NNP
cord-261028-sxux2ujo	167	5	Additional	Additional	NNP
cord-261028-sxux2ujo	167	6	"	"	``
cord-261028-sxux2ujo	167	7	eat	eat	VB
cord-261028-sxux2ujo	167	8	-	-	HYPH
cord-261028-sxux2ujo	167	9	me	-PRON-	PRP
cord-261028-sxux2ujo	167	10	"	"	''
cord-261028-sxux2ujo	167	11	signals	signal	NNS
cord-261028-sxux2ujo	167	12	have	have	VBP
cord-261028-sxux2ujo	167	13	been	be	VBN
cord-261028-sxux2ujo	167	14	shown	show	VBN
cord-261028-sxux2ujo	167	15	to	to	TO
cord-261028-sxux2ujo	167	16	result	result	VB
cord-261028-sxux2ujo	167	17	from	from	IN
cord-261028-sxux2ujo	167	18	changes	change	NNS
cord-261028-sxux2ujo	167	19	in	in	IN
cord-261028-sxux2ujo	167	20	expression	expression	NN
cord-261028-sxux2ujo	167	21	of	of	IN
cord-261028-sxux2ujo	167	22	ICAM-3	ICAM-3	NNP
cord-261028-sxux2ujo	167	23	,	,	,
cord-261028-sxux2ujo	167	24	Cq1	cq1	CD
cord-261028-sxux2ujo	167	25	,	,	,
cord-261028-sxux2ujo	167	26	oxidized	oxidized	JJ
cord-261028-sxux2ujo	167	27	lipids	lipid	NNS
cord-261028-sxux2ujo	167	28	and	and	CC
cord-261028-sxux2ujo	167	29	alterations	alteration	NNS
cord-261028-sxux2ujo	167	30	in	in	IN
cord-261028-sxux2ujo	167	31	glycosylation	glycosylation	NN
cord-261028-sxux2ujo	167	32	patterns	pattern	NNS
cord-261028-sxux2ujo	167	33	.	.	.
cord-261028-sxux2ujo	168	1	In	in	IN
cord-261028-sxux2ujo	168	2	the	the	DT
cord-261028-sxux2ujo	168	3	last	last	JJ
cord-261028-sxux2ujo	168	4	decade	decade	NN
cord-261028-sxux2ujo	168	5	,	,	,
cord-261028-sxux2ujo	168	6	several	several	JJ
cord-261028-sxux2ujo	168	7	new	new	JJ
cord-261028-sxux2ujo	168	8	receptors	receptor	NNS
cord-261028-sxux2ujo	168	9	and	and	CC
cord-261028-sxux2ujo	168	10	pathways	pathway	NNS
cord-261028-sxux2ujo	168	11	that	that	WDT
cord-261028-sxux2ujo	168	12	promote	promote	VBP
cord-261028-sxux2ujo	168	13	internalization	internalization	NN
cord-261028-sxux2ujo	168	14	of	of	IN
cord-261028-sxux2ujo	168	15	dying	die	VBG
cord-261028-sxux2ujo	168	16	cells	cell	NNS
cord-261028-sxux2ujo	168	17	have	have	VBP
cord-261028-sxux2ujo	168	18	been	be	VBN
cord-261028-sxux2ujo	168	19	identified	identify	VBN
cord-261028-sxux2ujo	168	20	and	and	CC
cord-261028-sxux2ujo	168	21	it	-PRON-	PRP
cord-261028-sxux2ujo	168	22	has	have	VBZ
cord-261028-sxux2ujo	168	23	become	become	VBN
cord-261028-sxux2ujo	168	24	clear	clear	JJ
cord-261028-sxux2ujo	168	25	that	that	IN
cord-261028-sxux2ujo	168	26	the	the	DT
cord-261028-sxux2ujo	168	27	expression	expression	NN
cord-261028-sxux2ujo	168	28	of	of	IN
cord-261028-sxux2ujo	168	29	these	these	DT
cord-261028-sxux2ujo	168	30	receptors	receptor	NNS
cord-261028-sxux2ujo	168	31	is	be	VBZ
cord-261028-sxux2ujo	168	32	associated	associate	VBN
cord-261028-sxux2ujo	168	33	with	with	IN
cord-261028-sxux2ujo	168	34	distinct	distinct	JJ
cord-261028-sxux2ujo	168	35	DC	DC	NNP
cord-261028-sxux2ujo	168	36	populations	population	NNS
cord-261028-sxux2ujo	168	37	.	.	.
cord-261028-sxux2ujo	169	1	Specifically	specifically	RB
cord-261028-sxux2ujo	169	2	,	,	,
cord-261028-sxux2ujo	169	3	expression	expression	NN
cord-261028-sxux2ujo	169	4	of	of	IN
cord-261028-sxux2ujo	169	5	DEC205	DEC205	NNP
cord-261028-sxux2ujo	169	6	,	,	,
cord-261028-sxux2ujo	169	7	Clec9a	Clec9a	NNP
cord-261028-sxux2ujo	169	8	and	and	CC
cord-261028-sxux2ujo	169	9	Axl	Axl	NNP
cord-261028-sxux2ujo	169	10	/	/	SYM
cord-261028-sxux2ujo	169	11	Lrp1/	Lrp1/	NNP
cord-261028-sxux2ujo	169	12	RANBP9	RANBP9	NNP
cord-261028-sxux2ujo	169	13	by	by	IN
cord-261028-sxux2ujo	169	14	cDC1	cDC1	NNP
cord-261028-sxux2ujo	169	15	has	have	VBZ
cord-261028-sxux2ujo	169	16	been	be	VBN
cord-261028-sxux2ujo	169	17	linked	link	VBN
cord-261028-sxux2ujo	169	18	to	to	IN
cord-261028-sxux2ujo	169	19	the	the	DT
cord-261028-sxux2ujo	169	20	uptake	uptake	NN
cord-261028-sxux2ujo	169	21	of	of	IN
cord-261028-sxux2ujo	169	22	dead	dead	JJ
cord-261028-sxux2ujo	169	23	and	and	CC
cord-261028-sxux2ujo	169	24	dying	die	VBG
cord-261028-sxux2ujo	169	25	cells	cell	NNS
cord-261028-sxux2ujo	169	26	(	(	-LRB-
cord-261028-sxux2ujo	169	27	Shrimpton	Shrimpton	NNP
cord-261028-sxux2ujo	169	28	et	et	NNP
cord-261028-sxux2ujo	169	29	al	al	NNP
cord-261028-sxux2ujo	169	30	.	.	NNP
cord-261028-sxux2ujo	169	31	,	,	,
cord-261028-sxux2ujo	169	32	2009	2009	CD
cord-261028-sxux2ujo	169	33	;	;	:
cord-261028-sxux2ujo	169	34	Sancho	Sancho	NNP
cord-261028-sxux2ujo	169	35	et	et	NNP
cord-261028-sxux2ujo	169	36	al	al	NNP
cord-261028-sxux2ujo	169	37	.	.	.
cord-261028-sxux2ujo	170	1	,	,	,
cord-261028-sxux2ujo	170	2	2009	2009	CD
cord-261028-sxux2ujo	170	3	;	;	:
cord-261028-sxux2ujo	170	4	Ramirez	Ramirez	NNP
cord-261028-sxux2ujo	170	5	-	-	HYPH
cord-261028-sxux2ujo	170	6	Ortiz	Ortiz	NNP
cord-261028-sxux2ujo	170	7	et	et	NNP
cord-261028-sxux2ujo	170	8	al	al	NNP
cord-261028-sxux2ujo	170	9	.	.	.
cord-261028-sxux2ujo	171	1	,	,	,
cord-261028-sxux2ujo	171	2	2013	2013	CD
cord-261028-sxux2ujo	171	3	;	;	:
cord-261028-sxux2ujo	171	4	Zelenay	Zelenay	NNP
cord-261028-sxux2ujo	171	5	et	et	FW
cord-261028-sxux2ujo	171	6	al	al	NNP
cord-261028-sxux2ujo	171	7	.	.	NNP
cord-261028-sxux2ujo	171	8	,	,	,
cord-261028-sxux2ujo	171	9	2012	2012	CD
cord-261028-sxux2ujo	171	10	;	;	:
cord-261028-sxux2ujo	171	11	Subramanian	Subramanian	NNP
cord-261028-sxux2ujo	171	12	et	et	NNP
cord-261028-sxux2ujo	171	13	al	al	NNP
cord-261028-sxux2ujo	171	14	.	.	NNP
cord-261028-sxux2ujo	171	15	,	,	,
cord-261028-sxux2ujo	171	16	2014	2014	CD
cord-261028-sxux2ujo	171	17	)	)	-RRB-
cord-261028-sxux2ujo	171	18	.	.	.
cord-261028-sxux2ujo	172	1	Intriguingly	intriguingly	RB
cord-261028-sxux2ujo	172	2	,	,	,
cord-261028-sxux2ujo	172	3	use	use	NN
cord-261028-sxux2ujo	172	4	of	of	IN
cord-261028-sxux2ujo	172	5	specific	specific	JJ
cord-261028-sxux2ujo	172	6	internalizing	internalize	VBG
cord-261028-sxux2ujo	172	7	receptors	receptor	NNS
cord-261028-sxux2ujo	172	8	has	have	VBZ
cord-261028-sxux2ujo	172	9	been	be	VBN
cord-261028-sxux2ujo	172	10	shown	show	VBN
cord-261028-sxux2ujo	172	11	to	to	TO
cord-261028-sxux2ujo	172	12	affect	affect	VB
cord-261028-sxux2ujo	172	13	subsequent	subsequent	JJ
cord-261028-sxux2ujo	172	14	endosomal	endosomal	JJ
cord-261028-sxux2ujo	172	15	trafficking	trafficking	NN
cord-261028-sxux2ujo	172	16	,	,	,
cord-261028-sxux2ujo	172	17	with	with	IN
cord-261028-sxux2ujo	172	18	receptors	receptor	NNS
cord-261028-sxux2ujo	172	19	that	that	WDT
cord-261028-sxux2ujo	172	20	promote	promote	VBP
cord-261028-sxux2ujo	172	21	uptake	uptake	NN
cord-261028-sxux2ujo	172	22	of	of	IN
cord-261028-sxux2ujo	172	23	smaller	small	JJR
cord-261028-sxux2ujo	172	24	particles	particle	NNS
cord-261028-sxux2ujo	172	25	associated	associate	VBN
cord-261028-sxux2ujo	172	26	with	with	IN
cord-261028-sxux2ujo	172	27	a	a	DT
cord-261028-sxux2ujo	172	28	slower	slow	JJR
cord-261028-sxux2ujo	172	29	endosomal	endosomal	JJ
cord-261028-sxux2ujo	172	30	acidification	acidification	NN
cord-261028-sxux2ujo	172	31	rate	rate	NN
cord-261028-sxux2ujo	172	32	.	.	.
cord-261028-sxux2ujo	173	1	The	the	DT
cord-261028-sxux2ujo	173	2	delayed	delay	VBN
cord-261028-sxux2ujo	173	3	endosomal	endosomal	JJ
cord-261028-sxux2ujo	173	4	acidification	acidification	NN
cord-261028-sxux2ujo	173	5	would	would	MD
cord-261028-sxux2ujo	173	6	reduce	reduce	VB
cord-261028-sxux2ujo	173	7	proteolytic	proteolytic	JJ
cord-261028-sxux2ujo	173	8	degradation	degradation	NN
cord-261028-sxux2ujo	173	9	and	and	CC
cord-261028-sxux2ujo	173	10	preserve	preserve	VB
cord-261028-sxux2ujo	173	11	antigenic	antigenic	JJ
cord-261028-sxux2ujo	173	12	structures	structure	NNS
cord-261028-sxux2ujo	173	13	,	,	,
cord-261028-sxux2ujo	173	14	thereby	thereby	RB
cord-261028-sxux2ujo	173	15	providing	provide	VBG
cord-261028-sxux2ujo	173	16	a	a	DT
cord-261028-sxux2ujo	173	17	longer	long	JJR
cord-261028-sxux2ujo	173	18	time	time	NN
cord-261028-sxux2ujo	173	19	-	-	HYPH
cord-261028-sxux2ujo	173	20	span	span	NN
cord-261028-sxux2ujo	173	21	where	where	WRB
cord-261028-sxux2ujo	173	22	antigens	antigen	NNS
cord-261028-sxux2ujo	173	23	can	can	MD
cord-261028-sxux2ujo	173	24	escape	escape	VB
cord-261028-sxux2ujo	173	25	into	into	IN
cord-261028-sxux2ujo	173	26	the	the	DT
cord-261028-sxux2ujo	173	27	cytosol	cytosol	NN
cord-261028-sxux2ujo	173	28	for	for	IN
cord-261028-sxux2ujo	173	29	processing	processing	NN
cord-261028-sxux2ujo	173	30	(	(	-LRB-
cord-261028-sxux2ujo	173	31	Compeer	Compeer	NNP
cord-261028-sxux2ujo	173	32	et	et	NNP
cord-261028-sxux2ujo	173	33	al	al	NNP
cord-261028-sxux2ujo	173	34	.	.	NNP
cord-261028-sxux2ujo	173	35	,	,	,
cord-261028-sxux2ujo	173	36	2012	2012	CD
cord-261028-sxux2ujo	173	37	;	;	:
cord-261028-sxux2ujo	173	38	Thacker	Thacker	NNP
cord-261028-sxux2ujo	173	39	and	and	CC
cord-261028-sxux2ujo	173	40	Janssen	Janssen	NNP
cord-261028-sxux2ujo	173	41	,	,	,
cord-261028-sxux2ujo	173	42	2012	2012	CD
cord-261028-sxux2ujo	173	43	;	;	:
cord-261028-sxux2ujo	173	44	Ackerman	Ackerman	NNP
cord-261028-sxux2ujo	173	45	and	and	CC
cord-261028-sxux2ujo	173	46	Cresswell	Cresswell	NNP
cord-261028-sxux2ujo	173	47	,	,	,
cord-261028-sxux2ujo	173	48	2004	2004	CD
cord-261028-sxux2ujo	173	49	;	;	:
cord-261028-sxux2ujo	174	1	Basha	Basha	NNP
cord-261028-sxux2ujo	174	2	et	et	NNP
cord-261028-sxux2ujo	174	3	al	al	NNP
cord-261028-sxux2ujo	174	4	.	.	NNP
cord-261028-sxux2ujo	174	5	,	,	,
cord-261028-sxux2ujo	174	6	2008	2008	CD
cord-261028-sxux2ujo	174	7	)	)	-RRB-
cord-261028-sxux2ujo	174	8	.	.	.
cord-261028-sxux2ujo	175	1	cDC1	cdc1	NN
cord-261028-sxux2ujo	176	1	already	already	RB
cord-261028-sxux2ujo	176	2	display	display	VB
cord-261028-sxux2ujo	176	3	an	an	DT
cord-261028-sxux2ujo	176	4	increased	increased	JJ
cord-261028-sxux2ujo	176	5	propensity	propensity	NN
cord-261028-sxux2ujo	176	6	for	for	IN
cord-261028-sxux2ujo	176	7	delayed	delay	VBN
cord-261028-sxux2ujo	176	8	endosomal	endosomal	NNP
cord-261028-sxux2ujo	176	9	/	/	SYM
cord-261028-sxux2ujo	176	10	lysosomal	lysosomal	JJ
cord-261028-sxux2ujo	176	11	fusion	fusion	NN
cord-261028-sxux2ujo	176	12	compared	compare	VBN
cord-261028-sxux2ujo	176	13	to	to	IN
cord-261028-sxux2ujo	176	14	other	other	JJ
cord-261028-sxux2ujo	176	15	DC	DC	NNP
cord-261028-sxux2ujo	176	16	populations	population	NNS
cord-261028-sxux2ujo	176	17	,	,	,
cord-261028-sxux2ujo	176	18	and	and	CC
cord-261028-sxux2ujo	176	19	one	one	PRP
cord-261028-sxux2ujo	176	20	can	can	MD
cord-261028-sxux2ujo	176	21	easily	easily	RB
cord-261028-sxux2ujo	176	22	envision	envision	VB
cord-261028-sxux2ujo	176	23	that	that	IN
cord-261028-sxux2ujo	176	24	different	different	JJ
cord-261028-sxux2ujo	176	25	combinations	combination	NNS
cord-261028-sxux2ujo	176	26	of	of	IN
cord-261028-sxux2ujo	176	27	DC	DC	NNP
cord-261028-sxux2ujo	176	28	populations	population	NNS
cord-261028-sxux2ujo	176	29	and	and	CC
cord-261028-sxux2ujo	176	30	endocytic	endocytic	JJ
cord-261028-sxux2ujo	176	31	receptor	receptor	NN
cord-261028-sxux2ujo	176	32	usage	usage	NN
cord-261028-sxux2ujo	176	33	will	will	MD
cord-261028-sxux2ujo	176	34	greatly	greatly	RB
cord-261028-sxux2ujo	176	35	affect	affect	VB
cord-261028-sxux2ujo	176	36	the	the	DT
cord-261028-sxux2ujo	176	37	efficacy	efficacy	NN
cord-261028-sxux2ujo	176	38	of	of	IN
cord-261028-sxux2ujo	176	39	a	a	DT
cord-261028-sxux2ujo	176	40	specific	specific	JJ
cord-261028-sxux2ujo	176	41	DCs	dc	NNS
cord-261028-sxux2ujo	176	42	in	in	IN
cord-261028-sxux2ujo	176	43	their	-PRON-	PRP$
cord-261028-sxux2ujo	176	44	capacity	capacity	NN
cord-261028-sxux2ujo	176	45	to	to	TO
cord-261028-sxux2ujo	176	46	cross	cross	VB
cord-261028-sxux2ujo	176	47	-	-	JJ
cord-261028-sxux2ujo	176	48	present	present	JJ
cord-261028-sxux2ujo	176	49	cell	cell	NN
cord-261028-sxux2ujo	176	50	-	-	HYPH
cord-261028-sxux2ujo	176	51	associated	associate	VBN
cord-261028-sxux2ujo	176	52	antigens	antigen	NNS
cord-261028-sxux2ujo	176	53	in	in	IN
cord-261028-sxux2ujo	176	54	the	the	DT
cord-261028-sxux2ujo	176	55	context	context	NN
cord-261028-sxux2ujo	176	56	of	of	IN
cord-261028-sxux2ujo	176	57	MHCI	MHCI	NNP
cord-261028-sxux2ujo	176	58	.	.	.
cord-261028-sxux2ujo	177	1	DCs	DCs	NNP
cord-261028-sxux2ujo	177	2	form	form	VBP
cord-261028-sxux2ujo	177	3	the	the	DT
cord-261028-sxux2ujo	177	4	cellular	cellular	JJ
cord-261028-sxux2ujo	177	5	link	link	NN
cord-261028-sxux2ujo	177	6	between	between	IN
cord-261028-sxux2ujo	177	7	innate	innate	JJ
cord-261028-sxux2ujo	177	8	and	and	CC
cord-261028-sxux2ujo	177	9	adaptive	adaptive	JJ
cord-261028-sxux2ujo	177	10	anti	anti	JJ
cord-261028-sxux2ujo	177	11	-	-	JJ
cord-261028-sxux2ujo	177	12	tumor	tumor	JJ
cord-261028-sxux2ujo	177	13	immunity	immunity	NN
cord-261028-sxux2ujo	177	14	,	,	,
cord-261028-sxux2ujo	177	15	but	but	CC
cord-261028-sxux2ujo	177	16	only	only	RB
cord-261028-sxux2ujo	177	17	in	in	IN
cord-261028-sxux2ujo	177	18	the	the	DT
cord-261028-sxux2ujo	177	19	context	context	NN
cord-261028-sxux2ujo	177	20	of	of	IN
cord-261028-sxux2ujo	177	21	the	the	DT
cord-261028-sxux2ujo	177	22	appropriate	appropriate	JJ
cord-261028-sxux2ujo	177	23	maturation	maturation	NN
cord-261028-sxux2ujo	177	24	signals	signal	NNS
cord-261028-sxux2ujo	177	25	.	.	.
cord-261028-sxux2ujo	178	1	The	the	DT
cord-261028-sxux2ujo	178	2	maturation	maturation	NN
cord-261028-sxux2ujo	178	3	status	status	NN
cord-261028-sxux2ujo	178	4	of	of	IN
cord-261028-sxux2ujo	178	5	the	the	DT
cord-261028-sxux2ujo	178	6	DC	DC	NNP
cord-261028-sxux2ujo	178	7	is	be	VBZ
cord-261028-sxux2ujo	178	8	critically	critically	RB
cord-261028-sxux2ujo	178	9	important	important	JJ
cord-261028-sxux2ujo	178	10	to	to	IN
cord-261028-sxux2ujo	178	11	the	the	DT
cord-261028-sxux2ujo	178	12	induction	induction	NN
cord-261028-sxux2ujo	178	13	of	of	IN
cord-261028-sxux2ujo	178	14	T	T	NNP
cord-261028-sxux2ujo	178	15	cell	cell	NN
cord-261028-sxux2ujo	178	16	responses	response	NNS
cord-261028-sxux2ujo	178	17	as	as	IN
cord-261028-sxux2ujo	178	18	it	-PRON-	PRP
cord-261028-sxux2ujo	178	19	dictates	dictate	VBZ
cord-261028-sxux2ujo	178	20	the	the	DT
cord-261028-sxux2ujo	178	21	expression	expression	NN
cord-261028-sxux2ujo	178	22	levels	level	NNS
cord-261028-sxux2ujo	178	23	of	of	IN
cord-261028-sxux2ujo	178	24	MHC	MHC	NNP
cord-261028-sxux2ujo	178	25	and	and	CC
cord-261028-sxux2ujo	178	26	membrane	membrane	NN
cord-261028-sxux2ujo	178	27	-	-	HYPH
cord-261028-sxux2ujo	178	28	associated	associate	VBN
cord-261028-sxux2ujo	178	29	and	and	CC
cord-261028-sxux2ujo	178	30	soluble	soluble	JJ
cord-261028-sxux2ujo	178	31	co	co	JJ
cord-261028-sxux2ujo	178	32	-	-	JJ
cord-261028-sxux2ujo	178	33	stimulatory	stimulatory	JJ
cord-261028-sxux2ujo	178	34	molecules	molecule	NNS
cord-261028-sxux2ujo	178	35	(	(	-LRB-
cord-261028-sxux2ujo	178	36	Lutz	Lutz	NNP
cord-261028-sxux2ujo	178	37	and	and	CC
cord-261028-sxux2ujo	178	38	Schuler	Schuler	NNP
cord-261028-sxux2ujo	178	39	,	,	,
cord-261028-sxux2ujo	178	40	2002	2002	CD
cord-261028-sxux2ujo	178	41	)	)	-RRB-
cord-261028-sxux2ujo	178	42	.	.	.
cord-261028-sxux2ujo	179	1	Immature	immature	JJ
cord-261028-sxux2ujo	179	2	DCs	dc	NNS
cord-261028-sxux2ujo	179	3	reside	reside	VBP
cord-261028-sxux2ujo	179	4	in	in	IN
cord-261028-sxux2ujo	179	5	the	the	DT
cord-261028-sxux2ujo	179	6	periphery	periphery	NN
cord-261028-sxux2ujo	179	7	and	and	CC
cord-261028-sxux2ujo	179	8	have	have	VB
cord-261028-sxux2ujo	179	9	great	great	JJ
cord-261028-sxux2ujo	179	10	capacity	capacity	NN
cord-261028-sxux2ujo	179	11	for	for	IN
cord-261028-sxux2ujo	179	12	endocytosis	endocytosis	NN
cord-261028-sxux2ujo	179	13	.	.	.
cord-261028-sxux2ujo	180	1	They	-PRON-	PRP
cord-261028-sxux2ujo	180	2	express	express	VBP
cord-261028-sxux2ujo	180	3	low	low	JJ
cord-261028-sxux2ujo	180	4	levels	level	NNS
cord-261028-sxux2ujo	180	5	of	of	IN
cord-261028-sxux2ujo	180	6	MHC	MHC	NNP
cord-261028-sxux2ujo	180	7	class	class	NN
cord-261028-sxux2ujo	180	8	I	i	NN
cord-261028-sxux2ujo	180	9	and	and	CC
cord-261028-sxux2ujo	180	10	II	II	NNP
cord-261028-sxux2ujo	180	11	,	,	,
cord-261028-sxux2ujo	180	12	and	and	CC
cord-261028-sxux2ujo	180	13	membrane	membrane	NN
cord-261028-sxux2ujo	180	14	associated	associate	VBN
cord-261028-sxux2ujo	180	15	co	co	JJ
cord-261028-sxux2ujo	180	16	-	-	JJ
cord-261028-sxux2ujo	180	17	stimulatory	stimulatory	JJ
cord-261028-sxux2ujo	180	18	molecules	molecule	NNS
cord-261028-sxux2ujo	180	19	including	include	VBG
cord-261028-sxux2ujo	180	20	CD40	CD40	NNP
cord-261028-sxux2ujo	180	21	,	,	,
cord-261028-sxux2ujo	180	22	CD80	CD80	NNP
cord-261028-sxux2ujo	180	23	and	and	CC
cord-261028-sxux2ujo	180	24	CD86	CD86	NNP
cord-261028-sxux2ujo	180	25	.	.	.
cord-261028-sxux2ujo	181	1	Upon	upon	IN
cord-261028-sxux2ujo	181	2	maturation	maturation	NN
cord-261028-sxux2ujo	181	3	,	,	,
cord-261028-sxux2ujo	181	4	DCs	dc	NNS
cord-261028-sxux2ujo	181	5	reduce	reduce	VBP
cord-261028-sxux2ujo	181	6	expression	expression	NN
cord-261028-sxux2ujo	181	7	of	of	IN
cord-261028-sxux2ujo	181	8	CCR6	CCR6	NNP
cord-261028-sxux2ujo	181	9	and	and	CC
cord-261028-sxux2ujo	181	10	increase	increase	VB
cord-261028-sxux2ujo	181	11	expression	expression	NN
cord-261028-sxux2ujo	181	12	of	of	IN
cord-261028-sxux2ujo	181	13	CCR7	CCR7	NNP
cord-261028-sxux2ujo	181	14	which	which	WDT
cord-261028-sxux2ujo	181	15	facilitates	facilitate	VBZ
cord-261028-sxux2ujo	181	16	homing	homing	NN
cord-261028-sxux2ujo	181	17	to	to	IN
cord-261028-sxux2ujo	181	18	the	the	DT
cord-261028-sxux2ujo	181	19	draining	drain	VBG
cord-261028-sxux2ujo	181	20	lymphoid	lymphoid	JJ
cord-261028-sxux2ujo	181	21	tissues	tissue	NNS
cord-261028-sxux2ujo	181	22	.	.	.
cord-261028-sxux2ujo	182	1	During	during	IN
cord-261028-sxux2ujo	182	2	migration	migration	NN
cord-261028-sxux2ujo	182	3	to	to	IN
cord-261028-sxux2ujo	182	4	the	the	DT
cord-261028-sxux2ujo	182	5	lymphatics	lymphatic	NNS
cord-261028-sxux2ujo	182	6	,	,	,
cord-261028-sxux2ujo	182	7	DCs	DCs	NNP
cord-261028-sxux2ujo	182	8	process	process	VBP
cord-261028-sxux2ujo	182	9	the	the	DT
cord-261028-sxux2ujo	182	10	endocytosed	endocytosed	JJ
cord-261028-sxux2ujo	182	11	antigens	antigen	NNS
cord-261028-sxux2ujo	182	12	for	for	IN
cord-261028-sxux2ujo	182	13	presentation	presentation	NN
cord-261028-sxux2ujo	182	14	in	in	IN
cord-261028-sxux2ujo	182	15	MHC	MHC	NNP
cord-261028-sxux2ujo	182	16	class	class	NN
cord-261028-sxux2ujo	182	17	I	i	NN
cord-261028-sxux2ujo	182	18	and	and	CC
cord-261028-sxux2ujo	182	19	II	II	NNP
cord-261028-sxux2ujo	182	20	molecules	molecule	NNS
cord-261028-sxux2ujo	182	21	,	,	,
cord-261028-sxux2ujo	182	22	and	and	CC
cord-261028-sxux2ujo	182	23	increase	increase	VB
cord-261028-sxux2ujo	182	24	the	the	DT
cord-261028-sxux2ujo	182	25	expression	expression	NN
cord-261028-sxux2ujo	182	26	of	of	IN
cord-261028-sxux2ujo	182	27	MHCI	MHCI	NNP
cord-261028-sxux2ujo	182	28	/	/	SYM
cord-261028-sxux2ujo	182	29	II	II	NNP
cord-261028-sxux2ujo	182	30	and	and	CC
cord-261028-sxux2ujo	182	31	activating	activate	VBG
cord-261028-sxux2ujo	182	32	costimulatory	costimulatory	NN
cord-261028-sxux2ujo	182	33	molecules	molecule	NNS
cord-261028-sxux2ujo	182	34	while	while	IN
cord-261028-sxux2ujo	182	35	acquiring	acquire	VBG
cord-261028-sxux2ujo	182	36	the	the	DT
cord-261028-sxux2ujo	182	37	capacity	capacity	NN
cord-261028-sxux2ujo	182	38	to	to	TO
cord-261028-sxux2ujo	182	39	produce	produce	VB
cord-261028-sxux2ujo	182	40	proinflammatory	proinflammatory	JJ
cord-261028-sxux2ujo	182	41	cytokines	cytokine	NNS
cord-261028-sxux2ujo	182	42	and	and	CC
cord-261028-sxux2ujo	182	43	chemokines	chemokine	NNS
cord-261028-sxux2ujo	182	44	that	that	WDT
cord-261028-sxux2ujo	182	45	will	will	MD
cord-261028-sxux2ujo	182	46	facilitate	facilitate	VB
cord-261028-sxux2ujo	182	47	their	-PRON-	PRP$
cord-261028-sxux2ujo	182	48	interaction	interaction	NN
cord-261028-sxux2ujo	182	49	with	with	IN
cord-261028-sxux2ujo	182	50	antigen	antigen	NN
cord-261028-sxux2ujo	182	51	-	-	HYPH
cord-261028-sxux2ujo	182	52	specific	specific	JJ
cord-261028-sxux2ujo	182	53	T	t	NN
cord-261028-sxux2ujo	182	54	cells	cell	NNS
cord-261028-sxux2ujo	182	55	.	.	.
cord-261028-sxux2ujo	183	1	In	in	IN
cord-261028-sxux2ujo	183	2	contrast	contrast	NN
cord-261028-sxux2ujo	183	3	to	to	IN
cord-261028-sxux2ujo	183	4	normal	normal	JJ
cord-261028-sxux2ujo	183	5	tissue	tissue	NN
cord-261028-sxux2ujo	183	6	DCs	dc	NNS
cord-261028-sxux2ujo	183	7	,	,	,
cord-261028-sxux2ujo	183	8	these	these	DT
cord-261028-sxux2ujo	183	9	essential	essential	JJ
cord-261028-sxux2ujo	183	10	functions	function	NNS
cord-261028-sxux2ujo	183	11	are	be	VBP
cord-261028-sxux2ujo	183	12	often	often	RB
cord-261028-sxux2ujo	183	13	impaired	impair	VBN
cord-261028-sxux2ujo	183	14	in	in	IN
cord-261028-sxux2ujo	183	15	TIDCs	tidc	NNS
cord-261028-sxux2ujo	183	16	,	,	,
cord-261028-sxux2ujo	183	17	which	which	WDT
cord-261028-sxux2ujo	183	18	can	can	MD
cord-261028-sxux2ujo	183	19	maintain	maintain	VB
cord-261028-sxux2ujo	183	20	their	-PRON-	PRP$
cord-261028-sxux2ujo	183	21	immature	immature	JJ
cord-261028-sxux2ujo	183	22	phenotype	phenotype	NN
cord-261028-sxux2ujo	183	23	.	.	.
cord-261028-sxux2ujo	184	1	This	this	DT
cord-261028-sxux2ujo	184	2	can	can	MD
cord-261028-sxux2ujo	184	3	contribute	contribute	VB
cord-261028-sxux2ujo	184	4	to	to	IN
cord-261028-sxux2ujo	184	5	tumor	tumor	NN
cord-261028-sxux2ujo	184	6	tolerance	tolerance	NN
cord-261028-sxux2ujo	184	7	,	,	,
cord-261028-sxux2ujo	184	8	and	and	CC
cord-261028-sxux2ujo	184	9	has	have	VBZ
cord-261028-sxux2ujo	184	10	been	be	VBN
cord-261028-sxux2ujo	184	11	suggested	suggest	VBN
cord-261028-sxux2ujo	184	12	to	to	TO
cord-261028-sxux2ujo	184	13	result	result	VB
cord-261028-sxux2ujo	184	14	from	from	IN
cord-261028-sxux2ujo	184	15	decreased	decreased	JJ
cord-261028-sxux2ujo	184	16	capacity	capacity	NN
cord-261028-sxux2ujo	184	17	to	to	TO
cord-261028-sxux2ujo	184	18	respond	respond	VB
cord-261028-sxux2ujo	184	19	to	to	IN
cord-261028-sxux2ujo	184	20	normal	normal	JJ
cord-261028-sxux2ujo	184	21	maturation	maturation	NN
cord-261028-sxux2ujo	184	22	signals	signal	NNS
cord-261028-sxux2ujo	184	23	as	as	IN
cord-261028-sxux2ujo	184	24	a	a	DT
cord-261028-sxux2ujo	184	25	result	result	NN
cord-261028-sxux2ujo	184	26	of	of	IN
cord-261028-sxux2ujo	184	27	immune	immune	JJ
cord-261028-sxux2ujo	184	28	suppressive	suppressive	JJ
cord-261028-sxux2ujo	184	29	mediators	mediator	NNS
cord-261028-sxux2ujo	184	30	produced	produce	VBN
cord-261028-sxux2ujo	184	31	by	by	IN
cord-261028-sxux2ujo	184	32	the	the	DT
cord-261028-sxux2ujo	184	33	tumor	tumor	NN
cord-261028-sxux2ujo	184	34	and	and	CC
cord-261028-sxux2ujo	184	35	its	-PRON-	PRP$
cord-261028-sxux2ujo	184	36	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	184	37	.	.	.
cord-261028-sxux2ujo	185	1	Several	several	JJ
cord-261028-sxux2ujo	185	2	pathways	pathway	NNS
cord-261028-sxux2ujo	185	3	for	for	IN
cord-261028-sxux2ujo	185	4	DC	DC	NNP
cord-261028-sxux2ujo	185	5	maturation	maturation	NN
cord-261028-sxux2ujo	185	6	have	have	VBP
cord-261028-sxux2ujo	185	7	been	be	VBN
cord-261028-sxux2ujo	185	8	identified	identify	VBN
cord-261028-sxux2ujo	185	9	,	,	,
cord-261028-sxux2ujo	185	10	with	with	IN
cord-261028-sxux2ujo	185	11	only	only	RB
cord-261028-sxux2ujo	185	12	some	some	DT
cord-261028-sxux2ujo	185	13	of	of	IN
cord-261028-sxux2ujo	185	14	them	-PRON-	PRP
cord-261028-sxux2ujo	185	15	relevant	relevant	JJ
cord-261028-sxux2ujo	185	16	to	to	IN
cord-261028-sxux2ujo	185	17	sterile	sterile	JJ
cord-261028-sxux2ujo	185	18	inflammation	inflammation	NN
cord-261028-sxux2ujo	185	19	and	and	CC
cord-261028-sxux2ujo	185	20	cancer	cancer	NN
cord-261028-sxux2ujo	185	21	,	,	,
cord-261028-sxux2ujo	185	22	although	although	IN
cord-261028-sxux2ujo	185	23	there	there	EX
cord-261028-sxux2ujo	185	24	is	be	VBZ
cord-261028-sxux2ujo	185	25	significant	significant	JJ
cord-261028-sxux2ujo	185	26	overlap	overlap	NN
cord-261028-sxux2ujo	185	27	between	between	IN
cord-261028-sxux2ujo	185	28	pathogen	pathogen	NN
cord-261028-sxux2ujo	185	29	sensing	sensing	NN
cord-261028-sxux2ujo	185	30	signals	signal	NNS
cord-261028-sxux2ujo	185	31	and	and	CC
cord-261028-sxux2ujo	185	32	signals	signal	NNS
cord-261028-sxux2ujo	185	33	that	that	WDT
cord-261028-sxux2ujo	185	34	mediate	mediate	VBP
cord-261028-sxux2ujo	185	35	sterile	sterile	JJ
cord-261028-sxux2ujo	185	36	inflammation	inflammation	NN
cord-261028-sxux2ujo	185	37	.	.	.
cord-261028-sxux2ujo	186	1	Most	Most	JJS
cord-261028-sxux2ujo	186	2	research	research	NN
cord-261028-sxux2ujo	186	3	has	have	VBZ
cord-261028-sxux2ujo	186	4	been	be	VBN
cord-261028-sxux2ujo	186	5	performed	perform	VBN
cord-261028-sxux2ujo	186	6	in	in	IN
cord-261028-sxux2ujo	186	7	the	the	DT
cord-261028-sxux2ujo	186	8	context	context	NN
cord-261028-sxux2ujo	186	9	of	of	IN
cord-261028-sxux2ujo	186	10	infectious	infectious	JJ
cord-261028-sxux2ujo	186	11	pathogens	pathogen	NNS
cord-261028-sxux2ujo	186	12	which	which	WDT
cord-261028-sxux2ujo	186	13	has	have	VBZ
cord-261028-sxux2ujo	186	14	led	lead	VBN
cord-261028-sxux2ujo	186	15	to	to	IN
cord-261028-sxux2ujo	186	16	the	the	DT
cord-261028-sxux2ujo	186	17	identification	identification	NN
cord-261028-sxux2ujo	186	18	of	of	IN
cord-261028-sxux2ujo	186	19	pathogen	pathogen	NN
cord-261028-sxux2ujo	186	20	-	-	HYPH
cord-261028-sxux2ujo	186	21	associated	associate	VBN
cord-261028-sxux2ujo	186	22	molecular	molecular	JJ
cord-261028-sxux2ujo	186	23	patterns	pattern	NNS
cord-261028-sxux2ujo	186	24	(	(	-LRB-
cord-261028-sxux2ujo	186	25	PAMPs	pamp	NNS
cord-261028-sxux2ujo	186	26	)	)	-RRB-
cord-261028-sxux2ujo	186	27	that	that	WDT
cord-261028-sxux2ujo	186	28	engage	engage	VBP
cord-261028-sxux2ujo	186	29	specific	specific	JJ
cord-261028-sxux2ujo	186	30	pattern	pattern	NN
cord-261028-sxux2ujo	186	31	recognition	recognition	NN
cord-261028-sxux2ujo	186	32	receptors	receptor	NNS
cord-261028-sxux2ujo	186	33	(	(	-LRB-
cord-261028-sxux2ujo	186	34	PRRs	PRRs	NNP
cord-261028-sxux2ujo	186	35	)	)	-RRB-
cord-261028-sxux2ujo	186	36	on	on	IN
cord-261028-sxux2ujo	186	37	the	the	DT
cord-261028-sxux2ujo	186	38	DC	DC	NNP
cord-261028-sxux2ujo	186	39	surface	surface	NN
cord-261028-sxux2ujo	186	40	and	and	CC
cord-261028-sxux2ujo	186	41	in	in	IN
cord-261028-sxux2ujo	186	42	intracellular	intracellular	JJ
cord-261028-sxux2ujo	186	43	vesicles	vesicle	NNS
cord-261028-sxux2ujo	186	44	.	.	.
cord-261028-sxux2ujo	187	1	Each	each	DT
cord-261028-sxux2ujo	187	2	DC	DC	NNP
cord-261028-sxux2ujo	187	3	subset	subset	NN
cord-261028-sxux2ujo	187	4	has	have	VBZ
cord-261028-sxux2ujo	187	5	its	-PRON-	PRP$
cord-261028-sxux2ujo	187	6	own	own	JJ
cord-261028-sxux2ujo	187	7	unique	unique	JJ
cord-261028-sxux2ujo	187	8	expression	expression	NN
cord-261028-sxux2ujo	187	9	pattern	pattern	NN
cord-261028-sxux2ujo	187	10	of	of	IN
cord-261028-sxux2ujo	187	11	PPRs	ppr	NNS
cord-261028-sxux2ujo	187	12	,	,	,
cord-261028-sxux2ujo	187	13	causing	cause	VBG
cord-261028-sxux2ujo	187	14	these	these	DT
cord-261028-sxux2ujo	187	15	DC	DC	NNP
cord-261028-sxux2ujo	187	16	populations	population	NNS
cord-261028-sxux2ujo	187	17	to	to	TO
cord-261028-sxux2ujo	187	18	respond	respond	VB
cord-261028-sxux2ujo	187	19	differently	differently	RB
cord-261028-sxux2ujo	187	20	upon	upon	IN
cord-261028-sxux2ujo	187	21	engagement	engagement	NN
cord-261028-sxux2ujo	187	22	of	of	IN
cord-261028-sxux2ujo	187	23	the	the	DT
cord-261028-sxux2ujo	187	24	same	same	JJ
cord-261028-sxux2ujo	187	25	PPR	ppr	NN
cord-261028-sxux2ujo	187	26	,	,	,
cord-261028-sxux2ujo	187	27	providing	provide	VBG
cord-261028-sxux2ujo	187	28	highly	highly	RB
cord-261028-sxux2ujo	187	29	modulated	modulate	VBN
cord-261028-sxux2ujo	187	30	nuance	nuance	NN
cord-261028-sxux2ujo	187	31	to	to	IN
cord-261028-sxux2ujo	187	32	the	the	DT
cord-261028-sxux2ujo	187	33	immune	immune	JJ
cord-261028-sxux2ujo	187	34	response	response	NN
cord-261028-sxux2ujo	187	35	(	(	-LRB-
cord-261028-sxux2ujo	187	36	Segura	Segura	NNP
cord-261028-sxux2ujo	187	37	et	et	NNP
cord-261028-sxux2ujo	187	38	al	al	NNP
cord-261028-sxux2ujo	187	39	.	.	NNP
cord-261028-sxux2ujo	187	40	,	,	,
cord-261028-sxux2ujo	187	41	2010	2010	CD
cord-261028-sxux2ujo	187	42	)	)	-RRB-
cord-261028-sxux2ujo	187	43	.	.	.
cord-261028-sxux2ujo	188	1	There	there	EX
cord-261028-sxux2ujo	188	2	are	be	VBP
cord-261028-sxux2ujo	188	3	several	several	JJ
cord-261028-sxux2ujo	188	4	families	family	NNS
cord-261028-sxux2ujo	188	5	of	of	IN
cord-261028-sxux2ujo	188	6	PRRs	prr	NNS
cord-261028-sxux2ujo	188	7	,	,	,
cord-261028-sxux2ujo	188	8	including	include	VBG
cord-261028-sxux2ujo	188	9	the	the	DT
cord-261028-sxux2ujo	188	10	Toll	Toll	NNP
cord-261028-sxux2ujo	188	11	-	-	HYPH
cord-261028-sxux2ujo	188	12	like	like	JJ
cord-261028-sxux2ujo	188	13	receptors	receptor	NNS
cord-261028-sxux2ujo	188	14	(	(	-LRB-
cord-261028-sxux2ujo	188	15	TLRs	TLRs	NNP
cord-261028-sxux2ujo	188	16	)	)	-RRB-
cord-261028-sxux2ujo	188	17	and	and	CC
cord-261028-sxux2ujo	188	18	C	c	NN
cord-261028-sxux2ujo	188	19	-	-	HYPH
cord-261028-sxux2ujo	188	20	type	type	NN
cord-261028-sxux2ujo	188	21	lectin	lectin	NN
cord-261028-sxux2ujo	188	22	receptors	receptor	NNS
cord-261028-sxux2ujo	188	23	that	that	WDT
cord-261028-sxux2ujo	188	24	mainly	mainly	RB
cord-261028-sxux2ujo	188	25	recognize	recognize	VBP
cord-261028-sxux2ujo	188	26	extracellular	extracellular	JJ
cord-261028-sxux2ujo	188	27	stimuli	stimulus	NNS
cord-261028-sxux2ujo	188	28	,	,	,
cord-261028-sxux2ujo	188	29	and	and	CC
cord-261028-sxux2ujo	188	30	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	188	31	PRRs	prr	NNS
cord-261028-sxux2ujo	188	32	,	,	,
cord-261028-sxux2ujo	188	33	including	include	VBG
cord-261028-sxux2ujo	188	34	RIG	rig	NN
cord-261028-sxux2ujo	188	35	-	-	HYPH
cord-261028-sxux2ujo	188	36	I	i	NN
cord-261028-sxux2ujo	188	37	-	-	HYPH
cord-261028-sxux2ujo	188	38	like	like	JJ
cord-261028-sxux2ujo	188	39	receptors	receptor	NNS
cord-261028-sxux2ujo	188	40	(	(	-LRB-
cord-261028-sxux2ujo	188	41	RLRs	rlr	NNS
cord-261028-sxux2ujo	188	42	)	)	-RRB-
cord-261028-sxux2ujo	188	43	and	and	CC
cord-261028-sxux2ujo	188	44	NOD	nod	JJ
cord-261028-sxux2ujo	188	45	-	-	HYPH
cord-261028-sxux2ujo	188	46	like	like	JJ
cord-261028-sxux2ujo	188	47	receptors	receptor	NNS
cord-261028-sxux2ujo	188	48	(	(	-LRB-
cord-261028-sxux2ujo	188	49	NLRs	NLRs	NNP
cord-261028-sxux2ujo	188	50	)	)	-RRB-
cord-261028-sxux2ujo	188	51	that	that	WDT
cord-261028-sxux2ujo	188	52	are	be	VBP
cord-261028-sxux2ujo	188	53	critically	critically	RB
cord-261028-sxux2ujo	188	54	important	important	JJ
cord-261028-sxux2ujo	188	55	for	for	IN
cord-261028-sxux2ujo	188	56	the	the	DT
cord-261028-sxux2ujo	188	57	sensing	sensing	NN
cord-261028-sxux2ujo	188	58	of	of	IN
cord-261028-sxux2ujo	188	59	intracellular	intracellular	JJ
cord-261028-sxux2ujo	188	60	pathogens	pathogen	NNS
cord-261028-sxux2ujo	188	61	(	(	-LRB-
cord-261028-sxux2ujo	188	62	Kawai	Kawai	NNP
cord-261028-sxux2ujo	188	63	and	and	CC
cord-261028-sxux2ujo	188	64	Akira	Akira	NNP
cord-261028-sxux2ujo	188	65	,	,	,
cord-261028-sxux2ujo	188	66	2009	2009	CD
cord-261028-sxux2ujo	188	67	;	;	:
cord-261028-sxux2ujo	188	68	Loo	Loo	NNP
cord-261028-sxux2ujo	188	69	and	and	CC
cord-261028-sxux2ujo	188	70	Gale	Gale	NNP
cord-261028-sxux2ujo	188	71	,	,	,
cord-261028-sxux2ujo	188	72	2011	2011	CD
cord-261028-sxux2ujo	188	73	;	;	:
cord-261028-sxux2ujo	189	1	Elinav	Elinav	NNP
cord-261028-sxux2ujo	189	2	et	et	NNP
cord-261028-sxux2ujo	189	3	al	al	NNP
cord-261028-sxux2ujo	189	4	.	.	NNP
cord-261028-sxux2ujo	189	5	,	,	,
cord-261028-sxux2ujo	189	6	2011	2011	CD
cord-261028-sxux2ujo	189	7	;	;	:
cord-261028-sxux2ujo	189	8	Osorio	Osorio	NNP
cord-261028-sxux2ujo	189	9	and	and	CC
cord-261028-sxux2ujo	189	10	Reis	Reis	NNP
cord-261028-sxux2ujo	189	11	e	e	NNP
cord-261028-sxux2ujo	189	12	Sousa	Sousa	NNP
cord-261028-sxux2ujo	189	13	,	,	,
cord-261028-sxux2ujo	189	14	2011	2011	CD
cord-261028-sxux2ujo	189	15	;	;	:
cord-261028-sxux2ujo	189	16	Kawai	Kawai	NNP
cord-261028-sxux2ujo	189	17	and	and	CC
cord-261028-sxux2ujo	189	18	Akira	Akira	NNP
cord-261028-sxux2ujo	189	19	,	,	,
cord-261028-sxux2ujo	189	20	2011	2011	CD
cord-261028-sxux2ujo	189	21	;	;	:
cord-261028-sxux2ujo	189	22	Pandey	Pandey	NNP
cord-261028-sxux2ujo	189	23	et	et	NNP
cord-261028-sxux2ujo	189	24	al	al	NNP
cord-261028-sxux2ujo	189	25	.	.	NNP
cord-261028-sxux2ujo	189	26	,	,	,
cord-261028-sxux2ujo	189	27	2014	2014	CD
cord-261028-sxux2ujo	189	28	)	)	-RRB-
cord-261028-sxux2ujo	189	29	.	.	.
cord-261028-sxux2ujo	190	1	As	as	IN
cord-261028-sxux2ujo	190	2	maturation	maturation	NN
cord-261028-sxux2ujo	190	3	of	of	IN
cord-261028-sxux2ujo	190	4	DC	DC	NNP
cord-261028-sxux2ujo	190	5	by	by	IN
cord-261028-sxux2ujo	190	6	PRR	PRR	NNP
cord-261028-sxux2ujo	190	7	signaling	signaling	NN
cord-261028-sxux2ujo	190	8	has	have	VBZ
cord-261028-sxux2ujo	190	9	been	be	VBN
cord-261028-sxux2ujo	190	10	covered	cover	VBN
cord-261028-sxux2ujo	190	11	by	by	IN
cord-261028-sxux2ujo	190	12	various	various	JJ
cord-261028-sxux2ujo	190	13	other	other	JJ
cord-261028-sxux2ujo	190	14	reviews	review	NNS
cord-261028-sxux2ujo	190	15	,	,	,
cord-261028-sxux2ujo	190	16	we	-PRON-	PRP
cord-261028-sxux2ujo	190	17	will	will	MD
cord-261028-sxux2ujo	190	18	provide	provide	VB
cord-261028-sxux2ujo	190	19	a	a	DT
cord-261028-sxux2ujo	190	20	summary	summary	NN
cord-261028-sxux2ujo	190	21	of	of	IN
cord-261028-sxux2ujo	190	22	different	different	JJ
cord-261028-sxux2ujo	190	23	maturation	maturation	NN
cord-261028-sxux2ujo	190	24	signals	signal	NNS
cord-261028-sxux2ujo	190	25	,	,	,
cord-261028-sxux2ujo	190	26	with	with	IN
cord-261028-sxux2ujo	190	27	emphasis	emphasis	NN
cord-261028-sxux2ujo	190	28	on	on	IN
cord-261028-sxux2ujo	190	29	the	the	DT
cord-261028-sxux2ujo	190	30	STING	sting	NN
cord-261028-sxux2ujo	190	31	and	and	CC
cord-261028-sxux2ujo	190	32	type	type	VB
cord-261028-sxux2ujo	190	33	I	-PRON-	PRP
cord-261028-sxux2ujo	190	34	IFN	IFN	NNP
cord-261028-sxux2ujo	190	35	pathway	pathway	NN
cord-261028-sxux2ujo	190	36	.	.	.
cord-261028-sxux2ujo	191	1	TLRs	TLRs	NNP
cord-261028-sxux2ujo	191	2	were	be	VBD
cord-261028-sxux2ujo	191	3	the	the	DT
cord-261028-sxux2ujo	191	4	first	first	JJ
cord-261028-sxux2ujo	191	5	PRRs	prr	NNS
cord-261028-sxux2ujo	191	6	to	to	TO
cord-261028-sxux2ujo	191	7	be	be	VB
cord-261028-sxux2ujo	191	8	identified	identify	VBN
cord-261028-sxux2ujo	191	9	and	and	CC
cord-261028-sxux2ujo	191	10	in	in	IN
cord-261028-sxux2ujo	191	11	addition	addition	NN
cord-261028-sxux2ujo	191	12	to	to	IN
cord-261028-sxux2ujo	191	13	sensing	sense	VBG
cord-261028-sxux2ujo	191	14	PAMPs	pamp	NNS
cord-261028-sxux2ujo	191	15	,	,	,
cord-261028-sxux2ujo	191	16	they	-PRON-	PRP
cord-261028-sxux2ujo	191	17	can	can	MD
cord-261028-sxux2ujo	191	18	also	also	RB
cord-261028-sxux2ujo	191	19	detect	detect	VB
cord-261028-sxux2ujo	191	20	certain	certain	JJ
cord-261028-sxux2ujo	191	21	markers	marker	NNS
cord-261028-sxux2ujo	191	22	of	of	IN
cord-261028-sxux2ujo	191	23	sterile	sterile	JJ
cord-261028-sxux2ujo	191	24	,	,	,
cord-261028-sxux2ujo	191	25	lytic	lytic	JJ
cord-261028-sxux2ujo	191	26	cell	cell	NN
cord-261028-sxux2ujo	191	27	death	death	NN
cord-261028-sxux2ujo	191	28	,	,	,
cord-261028-sxux2ujo	191	29	implicating	implicate	VBG
cord-261028-sxux2ujo	191	30	them	-PRON-	PRP
cord-261028-sxux2ujo	191	31	in	in	IN
cord-261028-sxux2ujo	191	32	tumor	tumor	NN
cord-261028-sxux2ujo	191	33	immunity	immunity	NN
cord-261028-sxux2ujo	191	34	in	in	IN
cord-261028-sxux2ujo	191	35	addition	addition	NN
cord-261028-sxux2ujo	191	36	to	to	IN
cord-261028-sxux2ujo	191	37	infectious	infectious	JJ
cord-261028-sxux2ujo	191	38	processes	process	NNS
cord-261028-sxux2ujo	191	39	.	.	.
cord-261028-sxux2ujo	192	1	The	the	DT
cord-261028-sxux2ujo	192	2	TLRs	tlr	NNS
cord-261028-sxux2ujo	192	3	are	be	VBP
cord-261028-sxux2ujo	192	4	membrane	membrane	NN
cord-261028-sxux2ujo	192	5	bound	bind	VBN
cord-261028-sxux2ujo	192	6	receptors	receptor	NNS
cord-261028-sxux2ujo	192	7	that	that	WDT
cord-261028-sxux2ujo	192	8	include	include	VBP
cord-261028-sxux2ujo	192	9	at	at	IN
cord-261028-sxux2ujo	192	10	least	least	JJS
cord-261028-sxux2ujo	192	11	12	12	CD
cord-261028-sxux2ujo	192	12	(	(	-LRB-
cord-261028-sxux2ujo	192	13	mouse	mouse	NN
cord-261028-sxux2ujo	192	14	)	)	-RRB-
cord-261028-sxux2ujo	192	15	and	and	CC
cord-261028-sxux2ujo	192	16	10	10	CD
cord-261028-sxux2ujo	192	17	(	(	-LRB-
cord-261028-sxux2ujo	192	18	human	human	NN
cord-261028-sxux2ujo	192	19	)	)	-RRB-
cord-261028-sxux2ujo	192	20	proteins	protein	NNS
cord-261028-sxux2ujo	192	21	that	that	WDT
cord-261028-sxux2ujo	192	22	recognize	recognize	VBP
cord-261028-sxux2ujo	192	23	a	a	DT
cord-261028-sxux2ujo	192	24	wide	wide	JJ
cord-261028-sxux2ujo	192	25	range	range	NN
cord-261028-sxux2ujo	192	26	of	of	IN
cord-261028-sxux2ujo	192	27	PAMPs	pamp	NNS
cord-261028-sxux2ujo	192	28	and	and	CC
cord-261028-sxux2ujo	192	29	even	even	RB
cord-261028-sxux2ujo	192	30	some	some	DT
cord-261028-sxux2ujo	192	31	danger	danger	NN
cord-261028-sxux2ujo	192	32	-	-	HYPH
cord-261028-sxux2ujo	192	33	associated	associate	VBN
cord-261028-sxux2ujo	192	34	molecular	molecular	JJ
cord-261028-sxux2ujo	192	35	patterns	pattern	NNS
cord-261028-sxux2ujo	192	36	(	(	-LRB-
cord-261028-sxux2ujo	192	37	DAMPs	DAMPs	NNP
cord-261028-sxux2ujo	192	38	)	)	-RRB-
cord-261028-sxux2ujo	192	39	,	,	,
cord-261028-sxux2ujo	192	40	a	a	DT
cord-261028-sxux2ujo	192	41	broader	broad	JJR
cord-261028-sxux2ujo	192	42	term	term	NN
cord-261028-sxux2ujo	192	43	including	include	VBG
cord-261028-sxux2ujo	192	44	endogenous	endogenous	JJ
cord-261028-sxux2ujo	192	45	molecules	molecule	NNS
cord-261028-sxux2ujo	192	46	secreted	secrete	VBN
cord-261028-sxux2ujo	192	47	by	by	IN
cord-261028-sxux2ujo	192	48	cells	cell	NNS
cord-261028-sxux2ujo	192	49	undergoing	undergo	VBG
cord-261028-sxux2ujo	192	50	stress	stress	NN
cord-261028-sxux2ujo	192	51	,	,	,
cord-261028-sxux2ujo	192	52	or	or	CC
cord-261028-sxux2ujo	192	53	released	release	VBN
cord-261028-sxux2ujo	192	54	during	during	IN
cord-261028-sxux2ujo	192	55	tissue	tissue	NN
cord-261028-sxux2ujo	192	56	damage	damage	NN
cord-261028-sxux2ujo	192	57	and	and	CC
cord-261028-sxux2ujo	192	58	cell	cell	NN
cord-261028-sxux2ujo	192	59	death	death	NN
cord-261028-sxux2ujo	192	60	that	that	WDT
cord-261028-sxux2ujo	192	61	signal	signal	VBP
cord-261028-sxux2ujo	192	62	inflammation	inflammation	NN
cord-261028-sxux2ujo	192	63	.	.	.
cord-261028-sxux2ujo	193	1	Prokaryotic	prokaryotic	JJ
cord-261028-sxux2ujo	193	2	products	product	NNS
cord-261028-sxux2ujo	193	3	recognized	recognize	VBN
cord-261028-sxux2ujo	193	4	include	include	VBP
cord-261028-sxux2ujo	193	5	lipoproteins	lipoprotein	NNS
cord-261028-sxux2ujo	193	6	(	(	-LRB-
cord-261028-sxux2ujo	193	7	TLR½/6	TLR½/6	NNP
cord-261028-sxux2ujo	193	8	)	)	-RRB-
cord-261028-sxux2ujo	193	9	,	,	,
cord-261028-sxux2ujo	193	10	lipopolysaccharide	lipopolysaccharide	NN
cord-261028-sxux2ujo	193	11	(	(	-LRB-
cord-261028-sxux2ujo	193	12	TLR4	TLR4	NNP
cord-261028-sxux2ujo	193	13	)	)	-RRB-
cord-261028-sxux2ujo	193	14	,	,	,
cord-261028-sxux2ujo	193	15	and	and	CC
cord-261028-sxux2ujo	193	16	flagellin	flagellin	NNP
cord-261028-sxux2ujo	193	17	(	(	-LRB-
cord-261028-sxux2ujo	193	18	TLR5	TLR5	NNP
cord-261028-sxux2ujo	193	19	)	)	-RRB-
cord-261028-sxux2ujo	193	20	on	on	IN
cord-261028-sxux2ujo	193	21	the	the	DT
cord-261028-sxux2ujo	193	22	cell	cell	NN
cord-261028-sxux2ujo	193	23	surface	surface	NN
cord-261028-sxux2ujo	193	24	membrane	membrane	NN
cord-261028-sxux2ujo	193	25	.	.	.
cord-261028-sxux2ujo	194	1	The	the	DT
cord-261028-sxux2ujo	194	2	intracellular	intracellular	JJ
cord-261028-sxux2ujo	194	3	vesicle	vesicle	NN
cord-261028-sxux2ujo	194	4	-	-	HYPH
cord-261028-sxux2ujo	194	5	associated	associate	VBN
cord-261028-sxux2ujo	194	6	TLRs	TLRs	NNP
cord-261028-sxux2ujo	194	7	recognize	recognize	VBP
cord-261028-sxux2ujo	194	8	dsRNA	dsRNA	.
cord-261028-sxux2ujo	195	1	(	(	-LRB-
cord-261028-sxux2ujo	195	2	TLR3	TLR3	NNP
cord-261028-sxux2ujo	195	3	)	)	-RRB-
cord-261028-sxux2ujo	195	4	,	,	,
cord-261028-sxux2ujo	195	5	single	single	JJ
cord-261028-sxux2ujo	195	6	stranded	strand	VBN
cord-261028-sxux2ujo	195	7	RNA	RNA	NNP
cord-261028-sxux2ujo	195	8	(	(	-LRB-
cord-261028-sxux2ujo	195	9	ssRNA	ssrna	UH
cord-261028-sxux2ujo	195	10	,	,	,
cord-261028-sxux2ujo	195	11	TLR7/8	TLR7/8	NNP
cord-261028-sxux2ujo	195	12	)	)	-RRB-
cord-261028-sxux2ujo	195	13	and	and	CC
cord-261028-sxux2ujo	195	14	DNA	DNA	NNP
cord-261028-sxux2ujo	195	15	(	(	-LRB-
cord-261028-sxux2ujo	195	16	TLR9	TLR9	NNP
cord-261028-sxux2ujo	195	17	)	)	-RRB-
cord-261028-sxux2ujo	195	18	.	.	.
cord-261028-sxux2ujo	196	1	Depending	depend	VBG
cord-261028-sxux2ujo	196	2	on	on	IN
cord-261028-sxux2ujo	196	3	the	the	DT
cord-261028-sxux2ujo	196	4	type	type	NN
cord-261028-sxux2ujo	196	5	of	of	IN
cord-261028-sxux2ujo	196	6	TLR	TLR	NNP
cord-261028-sxux2ujo	196	7	,	,	,
cord-261028-sxux2ujo	196	8	its	-PRON-	PRP$
cord-261028-sxux2ujo	196	9	signaling	signaling	NN
cord-261028-sxux2ujo	196	10	requires	require	VBZ
cord-261028-sxux2ujo	196	11	one	one	CD
cord-261028-sxux2ujo	196	12	or	or	CC
cord-261028-sxux2ujo	196	13	several	several	JJ
cord-261028-sxux2ujo	196	14	of	of	IN
cord-261028-sxux2ujo	196	15	the	the	DT
cord-261028-sxux2ujo	196	16	adapter	adapter	NN
cord-261028-sxux2ujo	196	17	molecules	molecule	NNS
cord-261028-sxux2ujo	196	18	MyD88	MyD88	NNP
cord-261028-sxux2ujo	196	19	,	,	,
cord-261028-sxux2ujo	196	20	TRIF	TRIF	NNP
cord-261028-sxux2ujo	196	21	,	,	,
cord-261028-sxux2ujo	196	22	TIRAP	TIRAP	NNP
cord-261028-sxux2ujo	196	23	and	and	CC
cord-261028-sxux2ujo	196	24	TRAM	TRAM	NNP
cord-261028-sxux2ujo	196	25	,	,	,
cord-261028-sxux2ujo	196	26	followed	follow	VBN
cord-261028-sxux2ujo	196	27	by	by	IN
cord-261028-sxux2ujo	196	28	activation	activation	NN
cord-261028-sxux2ujo	196	29	downstream	downstream	JJ
cord-261028-sxux2ujo	196	30	mediators	mediator	NNS
cord-261028-sxux2ujo	196	31	which	which	WDT
cord-261028-sxux2ujo	196	32	ultimately	ultimately	RB
cord-261028-sxux2ujo	196	33	induce	induce	VBP
cord-261028-sxux2ujo	196	34	the	the	DT
cord-261028-sxux2ujo	196	35	translocation	translocation	NN
cord-261028-sxux2ujo	196	36	of	of	IN
cord-261028-sxux2ujo	196	37	NFκB	NFκB	NNP
cord-261028-sxux2ujo	196	38	or	or	CC
cord-261028-sxux2ujo	196	39	IFN	IFN	NNP
cord-261028-sxux2ujo	196	40	-	-	HYPH
cord-261028-sxux2ujo	196	41	regulatory	regulatory	JJ
cord-261028-sxux2ujo	196	42	factors	factor	NNS
cord-261028-sxux2ujo	196	43	(	(	-LRB-
cord-261028-sxux2ujo	196	44	IRFs	IRFs	NNP
cord-261028-sxux2ujo	196	45	)	)	-RRB-
cord-261028-sxux2ujo	196	46	,	,	,
cord-261028-sxux2ujo	196	47	including	include	VBG
cord-261028-sxux2ujo	196	48	IRF3	IRF3	NNP
cord-261028-sxux2ujo	196	49	,	,	,
cord-261028-sxux2ujo	196	50	IRF5	IRF5	NNP
cord-261028-sxux2ujo	196	51	,	,	,
cord-261028-sxux2ujo	196	52	and	and	CC
cord-261028-sxux2ujo	196	53	IRF7	IRF7	NNP
cord-261028-sxux2ujo	196	54	(	(	-LRB-
cord-261028-sxux2ujo	196	55	Kawai	Kawai	NNP
cord-261028-sxux2ujo	196	56	and	and	CC
cord-261028-sxux2ujo	196	57	Akira	Akira	NNP
cord-261028-sxux2ujo	196	58	,	,	,
cord-261028-sxux2ujo	196	59	2009	2009	CD
cord-261028-sxux2ujo	196	60	;	;	:
cord-261028-sxux2ujo	196	61	Kawai	Kawai	NNP
cord-261028-sxux2ujo	196	62	and	and	CC
cord-261028-sxux2ujo	196	63	Akira	Akira	NNP
cord-261028-sxux2ujo	196	64	,	,	,
cord-261028-sxux2ujo	196	65	2011	2011	CD
cord-261028-sxux2ujo	196	66	)	)	-RRB-
cord-261028-sxux2ujo	196	67	.	.	.
cord-261028-sxux2ujo	197	1	These	these	DT
cord-261028-sxux2ujo	197	2	receptors	receptor	NNS
cord-261028-sxux2ujo	197	3	can	can	MD
cord-261028-sxux2ujo	197	4	induce	induce	VB
cord-261028-sxux2ujo	197	5	the	the	DT
cord-261028-sxux2ujo	197	6	rapid	rapid	JJ
cord-261028-sxux2ujo	197	7	transcription	transcription	NN
cord-261028-sxux2ujo	197	8	of	of	IN
cord-261028-sxux2ujo	197	9	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	197	10	cytokines	cytokine	NNS
cord-261028-sxux2ujo	197	11	,	,	,
cord-261028-sxux2ujo	197	12	including	include	VBG
cord-261028-sxux2ujo	197	13	type	type	NN
cord-261028-sxux2ujo	197	14	I	-PRON-	PRP
cord-261028-sxux2ujo	197	15	IFN	IFN	NNP
cord-261028-sxux2ujo	197	16	,	,	,
cord-261028-sxux2ujo	197	17	IL-6	IL-6	NNP
cord-261028-sxux2ujo	197	18	,	,	,
cord-261028-sxux2ujo	197	19	TNFα	TNFα	NNP
cord-261028-sxux2ujo	197	20	,	,	,
cord-261028-sxux2ujo	197	21	and	and	CC
cord-261028-sxux2ujo	197	22	IL-12	IL-12	NNP
cord-261028-sxux2ujo	197	23	.	.	.
cord-261028-sxux2ujo	198	1	Non	non	JJ
cord-261028-sxux2ujo	198	2	-	-	JJ
cord-261028-sxux2ujo	198	3	mammalian	mammalian	JJ
cord-261028-sxux2ujo	198	4	carbohydrates	carbohydrate	NNS
cord-261028-sxux2ujo	198	5	such	such	JJ
cord-261028-sxux2ujo	198	6	as	as	IN
cord-261028-sxux2ujo	198	7	mannose	mannose	NN
cord-261028-sxux2ujo	198	8	and	and	CC
cord-261028-sxux2ujo	198	9	acetylglucosamine	acetylglucosamine	NN
cord-261028-sxux2ujo	198	10	form	form	NN
cord-261028-sxux2ujo	198	11	one	one	CD
cord-261028-sxux2ujo	198	12	such	such	JJ
cord-261028-sxux2ujo	198	13	class	class	NN
cord-261028-sxux2ujo	198	14	of	of	IN
cord-261028-sxux2ujo	198	15	PAMPs	pamp	NNS
cord-261028-sxux2ujo	198	16	recognized	recognize	VBN
cord-261028-sxux2ujo	198	17	by	by	IN
cord-261028-sxux2ujo	198	18	C	c	NN
cord-261028-sxux2ujo	198	19	-	-	HYPH
cord-261028-sxux2ujo	198	20	type	type	NN
cord-261028-sxux2ujo	198	21	lectin	lectin	NN
cord-261028-sxux2ujo	198	22	receptors	receptor	NNS
cord-261028-sxux2ujo	198	23	(	(	-LRB-
cord-261028-sxux2ujo	198	24	Osorio	Osorio	NNP
cord-261028-sxux2ujo	198	25	and	and	CC
cord-261028-sxux2ujo	198	26	Reis	Reis	NNP
cord-261028-sxux2ujo	198	27	e	e	NNP
cord-261028-sxux2ujo	198	28	Sousa	Sousa	NNP
cord-261028-sxux2ujo	198	29	,	,	,
cord-261028-sxux2ujo	198	30	2011	2011	CD
cord-261028-sxux2ujo	198	31	)	)	-RRB-
cord-261028-sxux2ujo	198	32	.	.	.
cord-261028-sxux2ujo	199	1	These	these	DT
cord-261028-sxux2ujo	199	2	receptors	receptor	NNS
cord-261028-sxux2ujo	199	3	are	be	VBP
cord-261028-sxux2ujo	199	4	clustered	cluster	VBN
cord-261028-sxux2ujo	199	5	into	into	IN
cord-261028-sxux2ujo	199	6	an	an	DT
cord-261028-sxux2ujo	199	7	activating	activate	VBG
cord-261028-sxux2ujo	199	8	group	group	NN
cord-261028-sxux2ujo	199	9	signaling	signal	VBG
cord-261028-sxux2ujo	199	10	through	through	IN
cord-261028-sxux2ujo	199	11	immunoreceptor	immunoreceptor	JJ
cord-261028-sxux2ujo	199	12	tyrosine	tyrosine	NN
cord-261028-sxux2ujo	199	13	-	-	HYPH
cord-261028-sxux2ujo	199	14	based	base	VBN
cord-261028-sxux2ujo	199	15	activation	activation	NN
cord-261028-sxux2ujo	199	16	(	(	-LRB-
cord-261028-sxux2ujo	199	17	ITAM	ITAM	NNP
cord-261028-sxux2ujo	199	18	)	)	-RRB-
cord-261028-sxux2ujo	199	19	like	like	IN
cord-261028-sxux2ujo	199	20	motifs	motif	NNS
cord-261028-sxux2ujo	199	21	and	and	CC
cord-261028-sxux2ujo	199	22	ITAMbinding	itambinde	VBG
cord-261028-sxux2ujo	199	23	FcRg	fcrg	NN
cord-261028-sxux2ujo	199	24	adaptor	adaptor	NN
cord-261028-sxux2ujo	199	25	molecules	molecule	NNS
cord-261028-sxux2ujo	199	26	,	,	,
cord-261028-sxux2ujo	199	27	and	and	CC
cord-261028-sxux2ujo	199	28	an	an	DT
cord-261028-sxux2ujo	199	29	inhibitory	inhibitory	JJ
cord-261028-sxux2ujo	199	30	group	group	NN
cord-261028-sxux2ujo	199	31	which	which	WDT
cord-261028-sxux2ujo	199	32	mediate	mediate	VBP
cord-261028-sxux2ujo	199	33	their	-PRON-	PRP$
cord-261028-sxux2ujo	199	34	effect	effect	NN
cord-261028-sxux2ujo	199	35	through	through	IN
cord-261028-sxux2ujo	199	36	immunoreceptor	immunoreceptor	JJ
cord-261028-sxux2ujo	199	37	tyrosine	tyrosine	NN
cord-261028-sxux2ujo	199	38	-	-	HYPH
cord-261028-sxux2ujo	199	39	based	base	VBN
cord-261028-sxux2ujo	199	40	inhibition	inhibition	NN
cord-261028-sxux2ujo	199	41	(	(	-LRB-
cord-261028-sxux2ujo	199	42	ITIM)-motifs	itim)-motifs	NN
cord-261028-sxux2ujo	199	43	.	.	.
cord-261028-sxux2ujo	200	1	While	while	IN
cord-261028-sxux2ujo	200	2	important	important	JJ
cord-261028-sxux2ujo	200	3	in	in	IN
cord-261028-sxux2ujo	200	4	sensing	sense	VBG
cord-261028-sxux2ujo	200	5	many	many	JJ
cord-261028-sxux2ujo	200	6	bacteria	bacteria	NNS
cord-261028-sxux2ujo	200	7	,	,	,
cord-261028-sxux2ujo	200	8	they	-PRON-	PRP
cord-261028-sxux2ujo	200	9	are	be	VBP
cord-261028-sxux2ujo	200	10	less	less	RBR
cord-261028-sxux2ujo	200	11	relevant	relevant	JJ
cord-261028-sxux2ujo	200	12	to	to	TO
cord-261028-sxux2ujo	200	13	innate	innate	VB
cord-261028-sxux2ujo	200	14	immune	immune	JJ
cord-261028-sxux2ujo	200	15	sensing	sensing	NN
cord-261028-sxux2ujo	200	16	of	of	IN
cord-261028-sxux2ujo	200	17	cancer	cancer	NN
cord-261028-sxux2ujo	200	18	.	.	.
cord-261028-sxux2ujo	201	1	:	:	:
cord-261028-sxux2ujo	202	1	NOD	nod	VB
cord-261028-sxux2ujo	202	2	-	-	HYPH
cord-261028-sxux2ujo	202	3	like	like	JJ
cord-261028-sxux2ujo	202	4	receptors	receptor	NNS
cord-261028-sxux2ujo	202	5	(	(	-LRB-
cord-261028-sxux2ujo	202	6	NLRs	NLRs	NNP
cord-261028-sxux2ujo	202	7	)	)	-RRB-
cord-261028-sxux2ujo	202	8	encompass	encompass	VBP
cord-261028-sxux2ujo	202	9	group	group	NN
cord-261028-sxux2ujo	202	10	of	of	IN
cord-261028-sxux2ujo	202	11	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	202	12	innate	innate	JJ
cord-261028-sxux2ujo	202	13	sensors	sensor	NNS
cord-261028-sxux2ujo	202	14	that	that	WDT
cord-261028-sxux2ujo	202	15	predominantly	predominantly	RB
cord-261028-sxux2ujo	202	16	recognize	recognize	VBP
cord-261028-sxux2ujo	202	17	bacterial	bacterial	JJ
cord-261028-sxux2ujo	202	18	cell	cell	NN
cord-261028-sxux2ujo	202	19	components	component	NNS
cord-261028-sxux2ujo	202	20	.	.	.
cord-261028-sxux2ujo	203	1	Upon	upon	IN
cord-261028-sxux2ujo	203	2	engagement	engagement	NN
cord-261028-sxux2ujo	203	3	with	with	IN
cord-261028-sxux2ujo	203	4	their	-PRON-	PRP$
cord-261028-sxux2ujo	203	5	cognate	cognate	JJ
cord-261028-sxux2ujo	203	6	ligands	ligand	NNS
cord-261028-sxux2ujo	203	7	,	,	,
cord-261028-sxux2ujo	203	8	NLRs	NLRs	NNP
cord-261028-sxux2ujo	203	9	oligomerize	oligomerize	NNP
cord-261028-sxux2ujo	203	10	into	into	IN
cord-261028-sxux2ujo	203	11	a	a	DT
cord-261028-sxux2ujo	203	12	caspase-1-activating	caspase-1-activate	VBG
cord-261028-sxux2ujo	203	13	scaffold	scaffold	NN
cord-261028-sxux2ujo	203	14	known	know	VBN
cord-261028-sxux2ujo	203	15	as	as	IN
cord-261028-sxux2ujo	203	16	the	the	DT
cord-261028-sxux2ujo	203	17	inflammasome	inflammasome	NN
cord-261028-sxux2ujo	203	18	.	.	.
cord-261028-sxux2ujo	204	1	Active	active	JJ
cord-261028-sxux2ujo	204	2	caspase-1	caspase-1	NNP
cord-261028-sxux2ujo	204	3	subsequently	subsequently	RB
cord-261028-sxux2ujo	204	4	functions	function	VBZ
cord-261028-sxux2ujo	204	5	to	to	TO
cord-261028-sxux2ujo	204	6	cleave	cleave	VB
cord-261028-sxux2ujo	204	7	the	the	DT
cord-261028-sxux2ujo	204	8	proinflammatory	proinflammatory	JJ
cord-261028-sxux2ujo	204	9	IL-1	IL-1	NNP
cord-261028-sxux2ujo	204	10	family	family	NN
cord-261028-sxux2ujo	204	11	of	of	IN
cord-261028-sxux2ujo	204	12	cytokines	cytokine	NNS
cord-261028-sxux2ujo	204	13	into	into	IN
cord-261028-sxux2ujo	204	14	their	-PRON-	PRP$
cord-261028-sxux2ujo	204	15	bioactive	bioactive	JJ
cord-261028-sxux2ujo	204	16	forms	form	NNS
cord-261028-sxux2ujo	204	17	.	.	.
cord-261028-sxux2ujo	205	1	The	the	DT
cord-261028-sxux2ujo	205	2	AIM2-like	aim2-like	JJ
cord-261028-sxux2ujo	205	3	receptor	receptor	NN
cord-261028-sxux2ujo	205	4	(	(	-LRB-
cord-261028-sxux2ujo	205	5	ALR	ALR	NNP
cord-261028-sxux2ujo	205	6	)	)	-RRB-
cord-261028-sxux2ujo	205	7	or	or	CC
cord-261028-sxux2ujo	205	8	p200	p200	NNP
cord-261028-sxux2ujo	205	9	family	family	NN
cord-261028-sxux2ujo	205	10	contains	contain	VBZ
cord-261028-sxux2ujo	205	11	several	several	JJ
cord-261028-sxux2ujo	205	12	sensors	sensor	NNS
cord-261028-sxux2ujo	205	13	of	of	IN
cord-261028-sxux2ujo	205	14	cytoplasmic	cytoplasmic	JJ
cord-261028-sxux2ujo	205	15	DNA	dna	NN
cord-261028-sxux2ujo	205	16	,	,	,
cord-261028-sxux2ujo	205	17	including	include	VBG
cord-261028-sxux2ujo	205	18	IFI16	ifi16	NN
cord-261028-sxux2ujo	205	19	and	and	CC
cord-261028-sxux2ujo	205	20	AIM2	AIM2	NNP
cord-261028-sxux2ujo	205	21	.	.	.
cord-261028-sxux2ujo	206	1	Like	like	IN
cord-261028-sxux2ujo	206	2	the	the	DT
cord-261028-sxux2ujo	206	3	NLRs	nlr	NNS
cord-261028-sxux2ujo	206	4	,	,	,
cord-261028-sxux2ujo	206	5	AIM2	AIM2	NNP
cord-261028-sxux2ujo	206	6	functions	function	NNS
cord-261028-sxux2ujo	206	7	in	in	IN
cord-261028-sxux2ujo	206	8	an	an	DT
cord-261028-sxux2ujo	206	9	inflammasome	inflammasome	NN
cord-261028-sxux2ujo	206	10	that	that	IN
cord-261028-sxux2ujo	206	11	complexes	complex	NNS
cord-261028-sxux2ujo	206	12	with	with	IN
cord-261028-sxux2ujo	206	13	caspase-1	caspase-1	NNP
cord-261028-sxux2ujo	206	14	and	and	CC
cord-261028-sxux2ujo	206	15	promotes	promote	VBZ
cord-261028-sxux2ujo	206	16	the	the	DT
cord-261028-sxux2ujo	206	17	cleaving	cleaving	NN
cord-261028-sxux2ujo	206	18	of	of	IN
cord-261028-sxux2ujo	206	19	the	the	DT
cord-261028-sxux2ujo	206	20	proinflammatory	proinflammatory	JJ
cord-261028-sxux2ujo	206	21	IL-1	IL-1	NNP
cord-261028-sxux2ujo	206	22	family	family	NN
cord-261028-sxux2ujo	206	23	of	of	IN
cord-261028-sxux2ujo	206	24	cytokines	cytokine	NNS
cord-261028-sxux2ujo	206	25	.	.	.
cord-261028-sxux2ujo	207	1	Interestingly	interestingly	RB
cord-261028-sxux2ujo	207	2	,	,	,
cord-261028-sxux2ujo	207	3	while	while	IN
cord-261028-sxux2ujo	207	4	having	have	VBG
cord-261028-sxux2ujo	207	5	some	some	DT
cord-261028-sxux2ujo	207	6	homology	homology	NN
cord-261028-sxux2ujo	207	7	with	with	IN
cord-261028-sxux2ujo	207	8	AIM2	AIM2	NNP
cord-261028-sxux2ujo	207	9	,	,	,
cord-261028-sxux2ujo	207	10	the	the	DT
cord-261028-sxux2ujo	207	11	IFI16	ifi16	NN
cord-261028-sxux2ujo	207	12	(	(	-LRB-
cord-261028-sxux2ujo	207	13	mouse	mouse	NN
cord-261028-sxux2ujo	207	14	p204	p204	NNP
cord-261028-sxux2ujo	207	15	)	)	-RRB-
cord-261028-sxux2ujo	207	16	binds	bind	VBZ
cord-261028-sxux2ujo	207	17	dsDNA	dsdna	RB
cord-261028-sxux2ujo	207	18	,	,	,
cord-261028-sxux2ujo	207	19	but	but	CC
cord-261028-sxux2ujo	207	20	does	do	VBZ
cord-261028-sxux2ujo	207	21	not	not	RB
cord-261028-sxux2ujo	207	22	form	form	VB
cord-261028-sxux2ujo	207	23	an	an	DT
cord-261028-sxux2ujo	207	24	inflammasome	inflammasome	NN
cord-261028-sxux2ujo	207	25	,	,	,
cord-261028-sxux2ujo	207	26	and	and	CC
cord-261028-sxux2ujo	207	27	signals	signal	NNS
cord-261028-sxux2ujo	207	28	via	via	IN
cord-261028-sxux2ujo	207	29	STING	sting	NN
cord-261028-sxux2ujo	207	30	for	for	IN
cord-261028-sxux2ujo	207	31	the	the	DT
cord-261028-sxux2ujo	207	32	induction	induction	NN
cord-261028-sxux2ujo	207	33	of	of	IN
cord-261028-sxux2ujo	207	34	type	type	NN
cord-261028-sxux2ujo	207	35	I	-PRON-	PRP
cord-261028-sxux2ujo	207	36	IFNs	ifn	NNS
cord-261028-sxux2ujo	207	37	and	and	CC
cord-261028-sxux2ujo	207	38	other	other	JJ
cord-261028-sxux2ujo	207	39	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	207	40	mediators	mediator	NNS
cord-261028-sxux2ujo	207	41	.	.	.
cord-261028-sxux2ujo	208	1	Retinoic	retinoic	JJ
cord-261028-sxux2ujo	208	2	acid	acid	NN
cord-261028-sxux2ujo	208	3	inducible	inducible	JJ
cord-261028-sxux2ujo	208	4	gene	gene	NN
cord-261028-sxux2ujo	208	5	1	1	CD
cord-261028-sxux2ujo	209	1	(	(	-LRB-
cord-261028-sxux2ujo	209	2	RIG	rig	NN
cord-261028-sxux2ujo	209	3	-	-	:
cord-261028-sxux2ujo	209	4	I	I	NNP
cord-261028-sxux2ujo	209	5	,	,	,
cord-261028-sxux2ujo	209	6	or	or	CC
cord-261028-sxux2ujo	209	7	DDX58	ddx58	ADD
cord-261028-sxux2ujo	209	8	)	)	-RRB-
cord-261028-sxux2ujo	209	9	like	like	IN
cord-261028-sxux2ujo	209	10	receptors	receptor	NNS
cord-261028-sxux2ujo	209	11	are	be	VBP
cord-261028-sxux2ujo	209	12	another	another	DT
cord-261028-sxux2ujo	209	13	family	family	NN
cord-261028-sxux2ujo	209	14	of	of	IN
cord-261028-sxux2ujo	209	15	PRRs	prr	NNS
cord-261028-sxux2ujo	209	16	comprised	comprise	VBN
cord-261028-sxux2ujo	209	17	of	of	IN
cord-261028-sxux2ujo	209	18	DexD	DexD	NNP
cord-261028-sxux2ujo	209	19	/	/	SYM
cord-261028-sxux2ujo	209	20	H	h	NN
cord-261028-sxux2ujo	209	21	box	box	NN
cord-261028-sxux2ujo	209	22	RNA	RNA	NNP
cord-261028-sxux2ujo	209	23	helicases	helicase	NNS
cord-261028-sxux2ujo	209	24	that	that	WDT
cord-261028-sxux2ujo	209	25	play	play	VBP
cord-261028-sxux2ujo	209	26	an	an	DT
cord-261028-sxux2ujo	209	27	important	important	JJ
cord-261028-sxux2ujo	209	28	role	role	NN
cord-261028-sxux2ujo	209	29	in	in	IN
cord-261028-sxux2ujo	209	30	antiviral	antiviral	JJ
cord-261028-sxux2ujo	209	31	immunity	immunity	NN
cord-261028-sxux2ujo	209	32	that	that	WDT
cord-261028-sxux2ujo	209	33	detect	detect	VBP
cord-261028-sxux2ujo	209	34	viral	viral	JJ
cord-261028-sxux2ujo	209	35	associated	associate	VBN
cord-261028-sxux2ujo	209	36	RNA	RNA	NNP
cord-261028-sxux2ujo	209	37	(	(	-LRB-
cord-261028-sxux2ujo	209	38	Loo	Loo	NNP
cord-261028-sxux2ujo	209	39	and	and	CC
cord-261028-sxux2ujo	209	40	Gale	Gale	NNP
cord-261028-sxux2ujo	209	41	,	,	,
cord-261028-sxux2ujo	209	42	2011	2011	CD
cord-261028-sxux2ujo	209	43	)	)	-RRB-
cord-261028-sxux2ujo	209	44	.	.	.
cord-261028-sxux2ujo	210	1	This	this	DT
cord-261028-sxux2ujo	210	2	family	family	NN
cord-261028-sxux2ujo	210	3	encompasses	encompass	VBZ
cord-261028-sxux2ujo	210	4	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	210	5	proteins	protein	NNS
cord-261028-sxux2ujo	210	6	RIG-	RIG-	NNP
cord-261028-sxux2ujo	211	1	I	-PRON-	PRP
cord-261028-sxux2ujo	211	2	that	that	WDT
cord-261028-sxux2ujo	211	3	binds	bind	VBZ
cord-261028-sxux2ujo	211	4	5′-triphosphorylated	5′-triphosphorylated	CD
cord-261028-sxux2ujo	211	5	RNA	RNA	NNP
cord-261028-sxux2ujo	211	6	and	and	CC
cord-261028-sxux2ujo	211	7	short	short	JJ
cord-261028-sxux2ujo	211	8	double	double	NN
cord-261028-sxux2ujo	211	9	stranded	strand	VBN
cord-261028-sxux2ujo	211	10	RNA	RNA	NNP
cord-261028-sxux2ujo	211	11	(	(	-LRB-
cord-261028-sxux2ujo	211	12	dsRNA	dsrna	NN
cord-261028-sxux2ujo	211	13	)	)	-RRB-
cord-261028-sxux2ujo	211	14	,	,	,
cord-261028-sxux2ujo	211	15	and	and	CC
cord-261028-sxux2ujo	211	16	melanoma	melanoma	NN
cord-261028-sxux2ujo	211	17	differentiation	differentiation	NN
cord-261028-sxux2ujo	211	18	associated	associate	VBD
cord-261028-sxux2ujo	211	19	protein	protein	NN
cord-261028-sxux2ujo	211	20	5	5	CD
cord-261028-sxux2ujo	211	21	(	(	-LRB-
cord-261028-sxux2ujo	211	22	MDA5	MDA5	NNP
cord-261028-sxux2ujo	211	23	)	)	-RRB-
cord-261028-sxux2ujo	211	24	that	that	WDT
cord-261028-sxux2ujo	211	25	recognizes	recognize	VBZ
cord-261028-sxux2ujo	211	26	long	long	JJ
cord-261028-sxux2ujo	211	27	dsRNA	dsrna	NN
cord-261028-sxux2ujo	211	28	.	.	.
cord-261028-sxux2ujo	212	1	RIG	rig	NN
cord-261028-sxux2ujo	212	2	-	-	:
cord-261028-sxux2ujo	212	3	I	I	NNP
cord-261028-sxux2ujo	212	4	and	and	CC
cord-261028-sxux2ujo	212	5	MDA5	mda5	JJ
cord-261028-sxux2ujo	212	6	signal	signal	NN
cord-261028-sxux2ujo	212	7	via	via	IN
cord-261028-sxux2ujo	212	8	their	-PRON-	PRP$
cord-261028-sxux2ujo	212	9	caspase	caspase	NN
cord-261028-sxux2ujo	212	10	activation	activation	NN
cord-261028-sxux2ujo	212	11	and	and	CC
cord-261028-sxux2ujo	212	12	recruitment	recruitment	NN
cord-261028-sxux2ujo	212	13	domain	domain	NN
cord-261028-sxux2ujo	212	14	(	(	-LRB-
cord-261028-sxux2ujo	212	15	CARD	card	NN
cord-261028-sxux2ujo	212	16	)	)	-RRB-
cord-261028-sxux2ujo	212	17	to	to	IN
cord-261028-sxux2ujo	212	18	the	the	DT
cord-261028-sxux2ujo	212	19	mitochondrial	mitochondrial	JJ
cord-261028-sxux2ujo	212	20	antiviral	antiviral	JJ
cord-261028-sxux2ujo	212	21	signaling	signal	VBG
cord-261028-sxux2ujo	212	22	domain	domain	NN
cord-261028-sxux2ujo	212	23	(	(	-LRB-
cord-261028-sxux2ujo	212	24	MAVS	mavs	RB
cord-261028-sxux2ujo	212	25	,	,	,
cord-261028-sxux2ujo	212	26	also	also	RB
cord-261028-sxux2ujo	212	27	known	know	VBN
cord-261028-sxux2ujo	212	28	as	as	IN
cord-261028-sxux2ujo	212	29	Cardif	Cardif	NNP
cord-261028-sxux2ujo	212	30	or	or	CC
cord-261028-sxux2ujo	212	31	IPS-1	IPS-1	NNP
cord-261028-sxux2ujo	212	32	)	)	-RRB-
cord-261028-sxux2ujo	212	33	which	which	WDT
cord-261028-sxux2ujo	212	34	subsequently	subsequently	RB
cord-261028-sxux2ujo	212	35	stimulates	stimulate	VBZ
cord-261028-sxux2ujo	212	36	TBK1	TBK1	NNP
cord-261028-sxux2ujo	212	37	,	,	,
cord-261028-sxux2ujo	212	38	IKK	IKK	NNP
cord-261028-sxux2ujo	212	39	and	and	CC
cord-261028-sxux2ujo	212	40	the	the	DT
cord-261028-sxux2ujo	212	41	IRF	IRF	NNP
cord-261028-sxux2ujo	212	42	/	/	SYM
cord-261028-sxux2ujo	212	43	NFκB	nfκb	JJ
cord-261028-sxux2ujo	212	44	pathways	pathway	NNS
cord-261028-sxux2ujo	212	45	resulting	result	VBG
cord-261028-sxux2ujo	212	46	in	in	IN
cord-261028-sxux2ujo	212	47	the	the	DT
cord-261028-sxux2ujo	212	48	induction	induction	NN
cord-261028-sxux2ujo	212	49	of	of	IN
cord-261028-sxux2ujo	212	50	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	212	51	cytokines	cytokine	NNS
cord-261028-sxux2ujo	212	52	.	.	.
cord-261028-sxux2ujo	213	1	Additional	additional	JJ
cord-261028-sxux2ujo	213	2	studies	study	NNS
cord-261028-sxux2ujo	213	3	indicate	indicate	VBP
cord-261028-sxux2ujo	213	4	that	that	IN
cord-261028-sxux2ujo	213	5	,	,	,
cord-261028-sxux2ujo	213	6	for	for	IN
cord-261028-sxux2ujo	213	7	specific	specific	JJ
cord-261028-sxux2ujo	213	8	viruses	virus	NNS
cord-261028-sxux2ujo	213	9	,	,	,
cord-261028-sxux2ujo	213	10	the	the	DT
cord-261028-sxux2ujo	213	11	RIG	rig	NN
cord-261028-sxux2ujo	213	12	-	-	:
cord-261028-sxux2ujo	213	13	I	-PRON-	PRP
cord-261028-sxux2ujo	213	14	pathway	pathway	NN
cord-261028-sxux2ujo	213	15	converges	converge	VBZ
cord-261028-sxux2ujo	213	16	with	with	IN
cord-261028-sxux2ujo	213	17	the	the	DT
cord-261028-sxux2ujo	213	18	STING	sting	NN
cord-261028-sxux2ujo	213	19	pathway	pathway	NN
cord-261028-sxux2ujo	213	20	potentiating	potentiate	VBG
cord-261028-sxux2ujo	213	21	the	the	DT
cord-261028-sxux2ujo	213	22	anti	anti	JJ
cord-261028-sxux2ujo	213	23	-	-	JJ
cord-261028-sxux2ujo	213	24	viral	viral	JJ
cord-261028-sxux2ujo	213	25	response	response	NN
cord-261028-sxux2ujo	213	26	.	.	.
cord-261028-sxux2ujo	214	1	Recently	recently	RB
cord-261028-sxux2ujo	214	2	,	,	,
cord-261028-sxux2ujo	214	3	STING	STING	NNP
cord-261028-sxux2ujo	214	4	has	have	VBZ
cord-261028-sxux2ujo	214	5	been	be	VBN
cord-261028-sxux2ujo	214	6	identified	identify	VBN
cord-261028-sxux2ujo	214	7	as	as	IN
cord-261028-sxux2ujo	214	8	an	an	DT
cord-261028-sxux2ujo	214	9	important	important	JJ
cord-261028-sxux2ujo	214	10	regulator	regulator	NN
cord-261028-sxux2ujo	214	11	of	of	IN
cord-261028-sxux2ujo	214	12	immunity	immunity	NN
cord-261028-sxux2ujo	214	13	by	by	IN
cord-261028-sxux2ujo	214	14	mediating	mediate	VBG
cord-261028-sxux2ujo	214	15	type	type	NN
cord-261028-sxux2ujo	215	1	I	-PRON-	PRP
cord-261028-sxux2ujo	215	2	IFN	IFN	NNP
cord-261028-sxux2ujo	215	3	production	production	NN
cord-261028-sxux2ujo	215	4	in	in	IN
cord-261028-sxux2ujo	215	5	response	response	NN
cord-261028-sxux2ujo	215	6	to	to	IN
cord-261028-sxux2ujo	215	7	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	215	8	DNA	DNA	NNP
cord-261028-sxux2ujo	215	9	(	(	-LRB-
cord-261028-sxux2ujo	215	10	Burdette	Burdette	NNP
cord-261028-sxux2ujo	215	11	and	and	CC
cord-261028-sxux2ujo	215	12	Vance	Vance	NNP
cord-261028-sxux2ujo	215	13	,	,	,
cord-261028-sxux2ujo	215	14	2013	2013	CD
cord-261028-sxux2ujo	215	15	;	;	:
cord-261028-sxux2ujo	216	1	Ishikawa	Ishikawa	NNP
cord-261028-sxux2ujo	216	2	et	et	NNP
cord-261028-sxux2ujo	216	3	al	al	NNP
cord-261028-sxux2ujo	216	4	.	.	NNP
cord-261028-sxux2ujo	216	5	,	,	,
cord-261028-sxux2ujo	216	6	2009	2009	CD
cord-261028-sxux2ujo	216	7	)	)	-RRB-
cord-261028-sxux2ujo	216	8	.	.	.
cord-261028-sxux2ujo	217	1	STING	STING	NNP
cord-261028-sxux2ujo	217	2	is	be	VBZ
cord-261028-sxux2ujo	217	3	a	a	DT
cord-261028-sxux2ujo	217	4	protein	protein	NN
cord-261028-sxux2ujo	217	5	sensor	sensor	NN
cord-261028-sxux2ujo	217	6	of	of	IN
cord-261028-sxux2ujo	217	7	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	217	8	DNA	dna	NN
cord-261028-sxux2ujo	217	9	anchored	anchor	VBN
cord-261028-sxux2ujo	217	10	in	in	IN
cord-261028-sxux2ujo	217	11	the	the	DT
cord-261028-sxux2ujo	217	12	ER	ER	NNP
cord-261028-sxux2ujo	217	13	.	.	.
cord-261028-sxux2ujo	218	1	While	while	IN
cord-261028-sxux2ujo	218	2	initial	initial	JJ
cord-261028-sxux2ujo	218	3	studies	study	NNS
cord-261028-sxux2ujo	218	4	suggested	suggest	VBD
cord-261028-sxux2ujo	218	5	that	that	IN
cord-261028-sxux2ujo	218	6	STING	STING	NNP
cord-261028-sxux2ujo	218	7	may	may	MD
cord-261028-sxux2ujo	218	8	sense	sense	VB
cord-261028-sxux2ujo	218	9	DNA	dna	NN
cord-261028-sxux2ujo	218	10	structures	structure	NNS
cord-261028-sxux2ujo	218	11	directly	directly	RB
cord-261028-sxux2ujo	218	12	,	,	,
cord-261028-sxux2ujo	218	13	it	-PRON-	PRP
cord-261028-sxux2ujo	218	14	is	be	VBZ
cord-261028-sxux2ujo	218	15	now	now	RB
cord-261028-sxux2ujo	218	16	widely	widely	RB
cord-261028-sxux2ujo	218	17	accepted	accept	VBN
cord-261028-sxux2ujo	218	18	that	that	IN
cord-261028-sxux2ujo	218	19	other	other	JJ
cord-261028-sxux2ujo	218	20	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	218	21	DNA	dna	NN
cord-261028-sxux2ujo	218	22	binding	binding	NN
cord-261028-sxux2ujo	218	23	molecules	molecule	NNS
cord-261028-sxux2ujo	218	24	upstream	upstream	RB
cord-261028-sxux2ujo	218	25	of	of	IN
cord-261028-sxux2ujo	218	26	STING	sting	NN
cord-261028-sxux2ujo	218	27	are	be	VBP
cord-261028-sxux2ujo	218	28	required	require	VBN
cord-261028-sxux2ujo	218	29	for	for	IN
cord-261028-sxux2ujo	218	30	the	the	DT
cord-261028-sxux2ujo	218	31	activation	activation	NN
cord-261028-sxux2ujo	218	32	of	of	IN
cord-261028-sxux2ujo	218	33	the	the	DT
cord-261028-sxux2ujo	218	34	pathway	pathway	NN
cord-261028-sxux2ujo	218	35	.	.	.
cord-261028-sxux2ujo	219	1	The	the	DT
cord-261028-sxux2ujo	219	2	cyclic	cyclic	JJ
cord-261028-sxux2ujo	219	3	-	-	HYPH
cord-261028-sxux2ujo	219	4	GMP	GMP	NNP
cord-261028-sxux2ujo	219	5	-	-	HYPH
cord-261028-sxux2ujo	219	6	AMP	AMP	NNP
cord-261028-sxux2ujo	219	7	synthase	synthase	NN
cord-261028-sxux2ujo	219	8	(	(	-LRB-
cord-261028-sxux2ujo	219	9	cGAS	cGAS	NNP
cord-261028-sxux2ujo	219	10	)	)	-RRB-
cord-261028-sxux2ujo	219	11	is	be	VBZ
cord-261028-sxux2ujo	219	12	considered	consider	VBN
cord-261028-sxux2ujo	219	13	the	the	DT
cord-261028-sxux2ujo	219	14	predominant	predominant	JJ
cord-261028-sxux2ujo	219	15	DNA	dna	NN
cord-261028-sxux2ujo	219	16	sensor	sensor	NN
cord-261028-sxux2ujo	219	17	in	in	IN
cord-261028-sxux2ujo	219	18	this	this	DT
cord-261028-sxux2ujo	219	19	pathway	pathway	NN
cord-261028-sxux2ujo	219	20	.	.	.
cord-261028-sxux2ujo	220	1	Upon	upon	IN
cord-261028-sxux2ujo	220	2	binding	bind	VBG
cord-261028-sxux2ujo	220	3	to	to	IN
cord-261028-sxux2ujo	220	4	DNA	dna	NN
cord-261028-sxux2ujo	220	5	in	in	IN
cord-261028-sxux2ujo	220	6	the	the	DT
cord-261028-sxux2ujo	220	7	cytosol	cytosol	NN
cord-261028-sxux2ujo	220	8	,	,	,
cord-261028-sxux2ujo	220	9	cGAS	cgas	NN
cord-261028-sxux2ujo	220	10	catalyzes	catalyze	VBZ
cord-261028-sxux2ujo	220	11	the	the	DT
cord-261028-sxux2ujo	220	12	synthesis	synthesis	NN
cord-261028-sxux2ujo	220	13	of	of	IN
cord-261028-sxux2ujo	220	14	cyclic	cyclic	JJ
cord-261028-sxux2ujo	220	15	GMP	GMP	NNP
cord-261028-sxux2ujo	220	16	-	-	HYPH
cord-261028-sxux2ujo	220	17	AMP	AMP	NNP
cord-261028-sxux2ujo	220	18	(	(	-LRB-
cord-261028-sxux2ujo	220	19	cGAMP	cGAMP	NNP
cord-261028-sxux2ujo	220	20	)	)	-RRB-
cord-261028-sxux2ujo	220	21	from	from	IN
cord-261028-sxux2ujo	220	22	guanosine	guanosine	JJ
cord-261028-sxux2ujo	220	23	triphosphate	triphosphate	NN
cord-261028-sxux2ujo	220	24	(	(	-LRB-
cord-261028-sxux2ujo	220	25	GTP	GTP	NNP
cord-261028-sxux2ujo	220	26	)	)	-RRB-
cord-261028-sxux2ujo	220	27	and	and	CC
cord-261028-sxux2ujo	220	28	adenosine	adenosine	NN
cord-261028-sxux2ujo	220	29	triphosphate	triphosphate	NN
cord-261028-sxux2ujo	220	30	(	(	-LRB-
cord-261028-sxux2ujo	220	31	ATP	ATP	NNP
cord-261028-sxux2ujo	220	32	)	)	-RRB-
cord-261028-sxux2ujo	221	1	(	(	-LRB-
cord-261028-sxux2ujo	221	2	Ablasser	Ablasser	NNP
cord-261028-sxux2ujo	221	3	et	et	FW
cord-261028-sxux2ujo	221	4	al	al	NNP
cord-261028-sxux2ujo	221	5	.	.	NNP
cord-261028-sxux2ujo	221	6	,	,	,
cord-261028-sxux2ujo	221	7	2013	2013	CD
cord-261028-sxux2ujo	221	8	;	;	:
cord-261028-sxux2ujo	221	9	Civril	Civril	NNP
cord-261028-sxux2ujo	221	10	et	et	NNP
cord-261028-sxux2ujo	221	11	al	al	NNP
cord-261028-sxux2ujo	221	12	.	.	NNP
cord-261028-sxux2ujo	221	13	,	,	,
cord-261028-sxux2ujo	221	14	2013	2013	CD
cord-261028-sxux2ujo	221	15	)	)	-RRB-
cord-261028-sxux2ujo	221	16	.	.	.
cord-261028-sxux2ujo	222	1	cGAMP	cGAMP	NNP
cord-261028-sxux2ujo	222	2	functions	function	NNS
cord-261028-sxux2ujo	222	3	as	as	IN
cord-261028-sxux2ujo	222	4	a	a	DT
cord-261028-sxux2ujo	222	5	second	second	JJ
cord-261028-sxux2ujo	222	6	messenger	messenger	NN
cord-261028-sxux2ujo	222	7	that	that	WDT
cord-261028-sxux2ujo	222	8	binds	bind	VBZ
cord-261028-sxux2ujo	222	9	to	to	IN
cord-261028-sxux2ujo	222	10	and	and	CC
cord-261028-sxux2ujo	222	11	activates	activate	VBZ
cord-261028-sxux2ujo	222	12	STING	sting	NN
cord-261028-sxux2ujo	222	13	,	,	,
cord-261028-sxux2ujo	222	14	resulting	result	VBG
cord-261028-sxux2ujo	222	15	in	in	IN
cord-261028-sxux2ujo	222	16	its	-PRON-	PRP$
cord-261028-sxux2ujo	222	17	trafficking	trafficking	NN
cord-261028-sxux2ujo	222	18	from	from	IN
cord-261028-sxux2ujo	222	19	the	the	DT
cord-261028-sxux2ujo	222	20	ER	ER	NNP
cord-261028-sxux2ujo	222	21	to	to	IN
cord-261028-sxux2ujo	222	22	the	the	DT
cord-261028-sxux2ujo	222	23	Golgi	Golgi	NNP
cord-261028-sxux2ujo	222	24	and	and	CC
cord-261028-sxux2ujo	222	25	on	on	IN
cord-261028-sxux2ujo	222	26	to	to	IN
cord-261028-sxux2ujo	222	27	perinuclear	perinuclear	NNP
cord-261028-sxux2ujo	222	28	endosomes	endosome	NNS
cord-261028-sxux2ujo	222	29	where	where	WRB
cord-261028-sxux2ujo	222	30	it	-PRON-	PRP
cord-261028-sxux2ujo	222	31	mediates	mediate	VBZ
cord-261028-sxux2ujo	222	32	subsequent	subsequent	JJ
cord-261028-sxux2ujo	222	33	signaling	signaling	NN
cord-261028-sxux2ujo	222	34	via	via	IN
cord-261028-sxux2ujo	222	35	phosphorylation	phosphorylation	NN
cord-261028-sxux2ujo	222	36	of	of	IN
cord-261028-sxux2ujo	222	37	tank	tank	NN
cord-261028-sxux2ujo	222	38	-	-	HYPH
cord-261028-sxux2ujo	222	39	binding	bind	VBG
cord-261028-sxux2ujo	222	40	kinase	kinase	NN
cord-261028-sxux2ujo	222	41	1	1	CD
cord-261028-sxux2ujo	222	42	(	(	-LRB-
cord-261028-sxux2ujo	222	43	TBK1	TBK1	NNP
cord-261028-sxux2ujo	222	44	)	)	-RRB-
cord-261028-sxux2ujo	222	45	and	and	CC
cord-261028-sxux2ujo	222	46	IRF3	IRF3	NNP
cord-261028-sxux2ujo	222	47	,	,	,
cord-261028-sxux2ujo	222	48	which	which	WDT
cord-261028-sxux2ujo	222	49	induces	induce	VBZ
cord-261028-sxux2ujo	222	50	transcription	transcription	NN
cord-261028-sxux2ujo	222	51	of	of	IN
cord-261028-sxux2ujo	222	52	type	type	NN
cord-261028-sxux2ujo	222	53	I	-PRON-	PRP
cord-261028-sxux2ujo	222	54	IFNs	ifn	NNS
cord-261028-sxux2ujo	222	55	and	and	CC
cord-261028-sxux2ujo	222	56	other	other	JJ
cord-261028-sxux2ujo	222	57	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	222	58	genes	gene	NNS
cord-261028-sxux2ujo	222	59	(	(	-LRB-
cord-261028-sxux2ujo	222	60	Fig	Fig	NNP
cord-261028-sxux2ujo	222	61	.	.	NNP
cord-261028-sxux2ujo	222	62	1	1	CD
cord-261028-sxux2ujo	222	63	)	)	-RRB-
cord-261028-sxux2ujo	222	64	.	.	.
cord-261028-sxux2ujo	223	1	While	while	IN
cord-261028-sxux2ujo	223	2	the	the	DT
cord-261028-sxux2ujo	223	3	cGAS	cgas	JJ
cord-261028-sxux2ujo	223	4	-	-	HYPH
cord-261028-sxux2ujo	223	5	cGAMP	cGAMP	NNP
cord-261028-sxux2ujo	223	6	pathway	pathway	NN
cord-261028-sxux2ujo	223	7	is	be	VBZ
cord-261028-sxux2ujo	223	8	considered	consider	VBN
cord-261028-sxux2ujo	223	9	the	the	DT
cord-261028-sxux2ujo	223	10	dominant	dominant	JJ
cord-261028-sxux2ujo	223	11	pathway	pathway	NN
cord-261028-sxux2ujo	223	12	,	,	,
cord-261028-sxux2ujo	223	13	there	there	EX
cord-261028-sxux2ujo	223	14	is	be	VBZ
cord-261028-sxux2ujo	223	15	evidence	evidence	NN
cord-261028-sxux2ujo	223	16	that	that	IN
cord-261028-sxux2ujo	223	17	other	other	JJ
cord-261028-sxux2ujo	223	18	sensors	sensor	NNS
cord-261028-sxux2ujo	223	19	recognize	recognize	VBP
cord-261028-sxux2ujo	223	20	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	223	21	DNA	dna	NN
cord-261028-sxux2ujo	223	22	associated	associate	VBN
cord-261028-sxux2ujo	223	23	with	with	IN
cord-261028-sxux2ujo	223	24	viral	viral	JJ
cord-261028-sxux2ujo	223	25	infection	infection	NN
cord-261028-sxux2ujo	223	26	and	and	CC
cord-261028-sxux2ujo	223	27	use	use	VB
cord-261028-sxux2ujo	223	28	the	the	DT
cord-261028-sxux2ujo	223	29	STING	sting	NN
cord-261028-sxux2ujo	223	30	-	-	HYPH
cord-261028-sxux2ujo	223	31	TBK	TBK	NNP
cord-261028-sxux2ujo	223	32	-	-	HYPH
cord-261028-sxux2ujo	223	33	IRF3	IRF3	NNP
cord-261028-sxux2ujo	223	34	pathway	pathway	NN
cord-261028-sxux2ujo	223	35	to	to	TO
cord-261028-sxux2ujo	223	36	induce	induce	VB
cord-261028-sxux2ujo	223	37	type	type	NN
cord-261028-sxux2ujo	223	38	I	-PRON-	PRP
cord-261028-sxux2ujo	223	39	IFN	IFN	NNP
cord-261028-sxux2ujo	223	40	responses	response	NNS
cord-261028-sxux2ujo	223	41	.	.	.
cord-261028-sxux2ujo	224	1	Among	among	IN
cord-261028-sxux2ujo	224	2	them	-PRON-	PRP
cord-261028-sxux2ujo	224	3	,	,	,
cord-261028-sxux2ujo	224	4	DNA	dna	NN
cord-261028-sxux2ujo	224	5	-	-	HYPH
cord-261028-sxux2ujo	224	6	dependent	dependent	JJ
cord-261028-sxux2ujo	224	7	activator	activator	NN
cord-261028-sxux2ujo	224	8	of	of	IN
cord-261028-sxux2ujo	224	9	IFN	IFN	NNP
cord-261028-sxux2ujo	224	10	-	-	HYPH
cord-261028-sxux2ujo	224	11	regulatory	regulatory	JJ
cord-261028-sxux2ujo	224	12	factor	factor	NN
cord-261028-sxux2ujo	224	13	(	(	-LRB-
cord-261028-sxux2ujo	224	14	DAI	DAI	NNP
cord-261028-sxux2ujo	224	15	)	)	-RRB-
cord-261028-sxux2ujo	225	1	,	,	,
cord-261028-sxux2ujo	225	2	DExD	DExD	NNP
cord-261028-sxux2ujo	225	3	/	/	SYM
cord-261028-sxux2ujo	225	4	H	H	NNP
cord-261028-sxux2ujo	225	5	-	-	HYPH
cord-261028-sxux2ujo	225	6	box	box	NN
cord-261028-sxux2ujo	225	7	RNA	RNA	NNP
cord-261028-sxux2ujo	225	8	helicase	helicase	NN
cord-261028-sxux2ujo	225	9	DDX41	DDX41	NNP
cord-261028-sxux2ujo	225	10	,	,	,
cord-261028-sxux2ujo	226	1	DNA	DNA	NNP
cord-261028-sxux2ujo	226	2	dependent	dependent	JJ
cord-261028-sxux2ujo	226	3	protein	protein	NN
cord-261028-sxux2ujo	226	4	kinase	kinase	NN
cord-261028-sxux2ujo	226	5	(	(	-LRB-
cord-261028-sxux2ujo	226	6	DNA	dna	NN
cord-261028-sxux2ujo	226	7	-	-	HYPH
cord-261028-sxux2ujo	226	8	PK	PK	NNP
cord-261028-sxux2ujo	226	9	)	)	-RRB-
cord-261028-sxux2ujo	226	10	,	,	,
cord-261028-sxux2ujo	226	11	and	and	CC
cord-261028-sxux2ujo	226	12	IFN	IFN	NNP
cord-261028-sxux2ujo	226	13	-	-	HYPH
cord-261028-sxux2ujo	226	14	γ	γ	NN
cord-261028-sxux2ujo	226	15	-	-	HYPH
cord-261028-sxux2ujo	226	16	inducible	inducible	JJ
cord-261028-sxux2ujo	226	17	protein	protein	NN
cord-261028-sxux2ujo	226	18	(	(	-LRB-
cord-261028-sxux2ujo	226	19	IFI16	ifi16	NN
cord-261028-sxux2ujo	226	20	in	in	IN
cord-261028-sxux2ujo	226	21	humans	human	NNS
cord-261028-sxux2ujo	226	22	and	and	CC
cord-261028-sxux2ujo	226	23	ifi204	ifi204	JJ
cord-261028-sxux2ujo	226	24	/	/	SYM
cord-261028-sxux2ujo	226	25	p204	p204	NNS
cord-261028-sxux2ujo	226	26	in	in	IN
cord-261028-sxux2ujo	226	27	mouse	mouse	NN
cord-261028-sxux2ujo	226	28	)	)	-RRB-
cord-261028-sxux2ujo	226	29	have	have	VBP
cord-261028-sxux2ujo	226	30	been	be	VBN
cord-261028-sxux2ujo	226	31	implied	imply	VBN
cord-261028-sxux2ujo	226	32	.	.	.
cord-261028-sxux2ujo	227	1	DAMPs	damp	NNS
cord-261028-sxux2ujo	228	1	-As	-As	:
cord-261028-sxux2ujo	228	2	with	with	IN
cord-261028-sxux2ujo	228	3	the	the	DT
cord-261028-sxux2ujo	228	4	immune	immune	JJ
cord-261028-sxux2ujo	228	5	response	response	NN
cord-261028-sxux2ujo	228	6	to	to	IN
cord-261028-sxux2ujo	228	7	pathogen	pathogen	NN
cord-261028-sxux2ujo	228	8	infections	infection	NNS
cord-261028-sxux2ujo	228	9	,	,	,
cord-261028-sxux2ujo	228	10	DCs	DCs	NNP
cord-261028-sxux2ujo	228	11	must	must	MD
cord-261028-sxux2ujo	228	12	be	be	VB
cord-261028-sxux2ujo	228	13	appropriately	appropriately	RB
cord-261028-sxux2ujo	228	14	activated	activate	VBN
cord-261028-sxux2ujo	228	15	in	in	IN
cord-261028-sxux2ujo	228	16	order	order	NN
cord-261028-sxux2ujo	228	17	to	to	IN
cord-261028-sxux2ujo	228	18	prime	prime	NNP
cord-261028-sxux2ujo	228	19	T	T	NNP
cord-261028-sxux2ujo	228	20	cell	cell	NN
cord-261028-sxux2ujo	228	21	responses	response	NNS
cord-261028-sxux2ujo	228	22	against	against	IN
cord-261028-sxux2ujo	228	23	cancer	cancer	NN
cord-261028-sxux2ujo	228	24	.	.	.
cord-261028-sxux2ujo	229	1	However	however	RB
cord-261028-sxux2ujo	229	2	,	,	,
cord-261028-sxux2ujo	229	3	uptake	uptake	NN
cord-261028-sxux2ujo	229	4	of	of	IN
cord-261028-sxux2ujo	229	5	dying	die	VBG
cord-261028-sxux2ujo	229	6	cells	cell	NNS
cord-261028-sxux2ujo	229	7	is	be	VBZ
cord-261028-sxux2ujo	229	8	generally	generally	RB
cord-261028-sxux2ujo	229	9	considered	consider	VBN
cord-261028-sxux2ujo	229	10	to	to	TO
cord-261028-sxux2ujo	229	11	be	be	VB
cord-261028-sxux2ujo	229	12	a	a	DT
cord-261028-sxux2ujo	229	13	tolerogenic	tolerogenic	JJ
cord-261028-sxux2ujo	229	14	event	event	NN
cord-261028-sxux2ujo	229	15	in	in	IN
cord-261028-sxux2ujo	229	16	order	order	NN
cord-261028-sxux2ujo	229	17	to	to	TO
cord-261028-sxux2ujo	229	18	maintain	maintain	VB
cord-261028-sxux2ujo	229	19	tissue	tissue	NN
cord-261028-sxux2ujo	229	20	homeostasis	homeostasis	NN
cord-261028-sxux2ujo	229	21	and	and	CC
cord-261028-sxux2ujo	229	22	prevent	prevent	VB
cord-261028-sxux2ujo	229	23	development	development	NN
cord-261028-sxux2ujo	229	24	of	of	IN
cord-261028-sxux2ujo	229	25	autoimmune	autoimmune	JJ
cord-261028-sxux2ujo	229	26	disorders	disorder	NNS
cord-261028-sxux2ujo	229	27	.	.	.
cord-261028-sxux2ujo	230	1	DCs	dc	NNS
cord-261028-sxux2ujo	230	2	that	that	WDT
cord-261028-sxux2ujo	230	3	have	have	VBP
cord-261028-sxux2ujo	230	4	phagocytosed	phagocytose	VBN
cord-261028-sxux2ujo	230	5	dying	dying	NN
cord-261028-sxux2ujo	230	6	cells	cell	NNS
cord-261028-sxux2ujo	230	7	have	have	VBP
cord-261028-sxux2ujo	230	8	been	be	VBN
cord-261028-sxux2ujo	230	9	reported	report	VBN
cord-261028-sxux2ujo	230	10	to	to	TO
cord-261028-sxux2ujo	230	11	produce	produce	VB
cord-261028-sxux2ujo	230	12	the	the	DT
cord-261028-sxux2ujo	230	13	immune	immune	JJ
cord-261028-sxux2ujo	230	14	-	-	HYPH
cord-261028-sxux2ujo	230	15	suppressive	suppressive	JJ
cord-261028-sxux2ujo	230	16	cytokines	cytokine	NNS
cord-261028-sxux2ujo	230	17	TGF	TGF	NNP
cord-261028-sxux2ujo	230	18	-	-	HYPH
cord-261028-sxux2ujo	230	19	β	β	NNP
cord-261028-sxux2ujo	230	20	and	and	CC
cord-261028-sxux2ujo	230	21	IL-10	IL-10	NNP
cord-261028-sxux2ujo	230	22	,	,	,
cord-261028-sxux2ujo	230	23	and	and	CC
cord-261028-sxux2ujo	230	24	are	be	VBP
cord-261028-sxux2ujo	230	25	significantly	significantly	RB
cord-261028-sxux2ujo	230	26	inhibited	inhibit	VBN
cord-261028-sxux2ujo	230	27	in	in	IN
cord-261028-sxux2ujo	230	28	their	-PRON-	PRP$
cord-261028-sxux2ujo	230	29	capacity	capacity	NN
cord-261028-sxux2ujo	230	30	to	to	TO
cord-261028-sxux2ujo	230	31	produce	produce	VB
cord-261028-sxux2ujo	230	32	pro	pro	JJ
cord-261028-sxux2ujo	230	33	-	-	JJ
cord-261028-sxux2ujo	230	34	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	230	35	cytokines	cytokine	NNS
cord-261028-sxux2ujo	230	36	and	and	CC
cord-261028-sxux2ujo	230	37	upregulate	upregulate	VB
cord-261028-sxux2ujo	230	38	co	co	JJ
cord-261028-sxux2ujo	230	39	-	-	JJ
cord-261028-sxux2ujo	230	40	stimulatory	stimulatory	JJ
cord-261028-sxux2ujo	230	41	molecules	molecule	NNS
cord-261028-sxux2ujo	230	42	.	.	.
cord-261028-sxux2ujo	231	1	One	one	CD
cord-261028-sxux2ujo	231	2	mechanism	mechanism	NN
cord-261028-sxux2ujo	231	3	for	for	IN
cord-261028-sxux2ujo	231	4	sensing	sense	VBG
cord-261028-sxux2ujo	231	5	cancer	cancer	NN
cord-261028-sxux2ujo	231	6	and	and	CC
cord-261028-sxux2ujo	231	7	developing	develop	VBG
cord-261028-sxux2ujo	231	8	inflammation	inflammation	NN
cord-261028-sxux2ujo	231	9	in	in	IN
cord-261028-sxux2ujo	231	10	a	a	DT
cord-261028-sxux2ujo	231	11	sterile	sterile	JJ
cord-261028-sxux2ujo	231	12	environment	environment	NN
cord-261028-sxux2ujo	231	13	involves	involve	VBZ
cord-261028-sxux2ujo	231	14	the	the	DT
cord-261028-sxux2ujo	231	15	release	release	NN
cord-261028-sxux2ujo	231	16	of	of	IN
cord-261028-sxux2ujo	231	17	endogenous	endogenous	JJ
cord-261028-sxux2ujo	231	18	molecules	molecule	NNS
cord-261028-sxux2ujo	231	19	that	that	WDT
cord-261028-sxux2ujo	231	20	serve	serve	VBP
cord-261028-sxux2ujo	231	21	as	as	IN
cord-261028-sxux2ujo	231	22	DAMPs	damp	NNS
cord-261028-sxux2ujo	231	23	,	,	,
cord-261028-sxux2ujo	231	24	which	which	WDT
cord-261028-sxux2ujo	231	25	can	can	MD
cord-261028-sxux2ujo	231	26	signal	signal	VB
cord-261028-sxux2ujo	231	27	through	through	IN
cord-261028-sxux2ujo	231	28	the	the	DT
cord-261028-sxux2ujo	231	29	same	same	JJ
cord-261028-sxux2ujo	231	30	PRRs	prr	NNS
cord-261028-sxux2ujo	231	31	that	that	WDT
cord-261028-sxux2ujo	231	32	sense	sense	VBP
cord-261028-sxux2ujo	231	33	pathogen	pathogen	NN
cord-261028-sxux2ujo	231	34	derived	derive	VBD
cord-261028-sxux2ujo	231	35	molecules	molecule	NNS
cord-261028-sxux2ujo	231	36	.	.	.
cord-261028-sxux2ujo	232	1	DAMPs	damp	NNS
cord-261028-sxux2ujo	232	2	encompass	encompass	VBP
cord-261028-sxux2ujo	232	3	cellular	cellular	JJ
cord-261028-sxux2ujo	232	4	components	component	NNS
cord-261028-sxux2ujo	232	5	and	and	CC
cord-261028-sxux2ujo	232	6	factors	factor	NNS
cord-261028-sxux2ujo	232	7	that	that	WDT
cord-261028-sxux2ujo	232	8	are	be	VBP
cord-261028-sxux2ujo	232	9	either	either	RB
cord-261028-sxux2ujo	232	10	present	present	JJ
cord-261028-sxux2ujo	232	11	before	before	IN
cord-261028-sxux2ujo	232	12	death	death	NN
cord-261028-sxux2ujo	232	13	and	and	CC
cord-261028-sxux2ujo	232	14	released	release	VBN
cord-261028-sxux2ujo	232	15	by	by	IN
cord-261028-sxux2ujo	232	16	dying	die	VBG
cord-261028-sxux2ujo	232	17	cells	cell	NNS
cord-261028-sxux2ujo	232	18	or	or	CC
cord-261028-sxux2ujo	232	19	generated	generate	VBN
cord-261028-sxux2ujo	232	20	as	as	IN
cord-261028-sxux2ujo	232	21	a	a	DT
cord-261028-sxux2ujo	232	22	result	result	NN
cord-261028-sxux2ujo	232	23	of	of	IN
cord-261028-sxux2ujo	232	24	cellular	cellular	JJ
cord-261028-sxux2ujo	232	25	stress	stress	NN
cord-261028-sxux2ujo	232	26	.	.	.
cord-261028-sxux2ujo	233	1	Examples	example	NNS
cord-261028-sxux2ujo	233	2	include	include	VBP
cord-261028-sxux2ujo	233	3	ATP	ATP	NNP
cord-261028-sxux2ujo	233	4	which	which	WDT
cord-261028-sxux2ujo	233	5	may	may	MD
cord-261028-sxux2ujo	233	6	engage	engage	VB
cord-261028-sxux2ujo	233	7	the	the	DT
cord-261028-sxux2ujo	233	8	NOD/	NOD/	NNP
cord-261028-sxux2ujo	233	9	NLRP3	NLRP3	NNP
cord-261028-sxux2ujo	233	10	inflammasome	inflammasome	NNP
cord-261028-sxux2ujo	233	11	,	,	,
cord-261028-sxux2ujo	233	12	HMGB1	HMGB1	NNP
cord-261028-sxux2ujo	233	13	which	which	WDT
cord-261028-sxux2ujo	233	14	has	have	VBZ
cord-261028-sxux2ujo	233	15	been	be	VBN
cord-261028-sxux2ujo	233	16	suggested	suggest	VBN
cord-261028-sxux2ujo	233	17	to	to	TO
cord-261028-sxux2ujo	233	18	signal	signal	VB
cord-261028-sxux2ujo	233	19	through	through	IN
cord-261028-sxux2ujo	233	20	TLR4	TLR4	NNP
cord-261028-sxux2ujo	233	21	,	,	,
cord-261028-sxux2ujo	233	22	filamentous	filamentous	JJ
cord-261028-sxux2ujo	233	23	actin	actin	NN
cord-261028-sxux2ujo	233	24	which	which	WDT
cord-261028-sxux2ujo	233	25	is	be	VBZ
cord-261028-sxux2ujo	233	26	recognized	recognize	VBN
cord-261028-sxux2ujo	233	27	by	by	IN
cord-261028-sxux2ujo	233	28	CLEC9a	CLEC9a	NNP
cord-261028-sxux2ujo	233	29	,	,	,
cord-261028-sxux2ujo	233	30	as	as	RB
cord-261028-sxux2ujo	233	31	well	well	RB
cord-261028-sxux2ujo	233	32	as	as	IN
cord-261028-sxux2ujo	233	33	heat	heat	NN
cord-261028-sxux2ujo	233	34	shock	shock	NN
cord-261028-sxux2ujo	233	35	proteins	protein	NNS
cord-261028-sxux2ujo	233	36	and	and	CC
cord-261028-sxux2ujo	233	37	uric	uric	NN
cord-261028-sxux2ujo	233	38	acid	acid	NN
cord-261028-sxux2ujo	234	1	(	(	-LRB-
cord-261028-sxux2ujo	234	2	Zhang	Zhang	NNP
cord-261028-sxux2ujo	234	3	et	et	NNP
cord-261028-sxux2ujo	234	4	al	al	NNP
cord-261028-sxux2ujo	234	5	.	.	NNP
cord-261028-sxux2ujo	234	6	,	,	,
cord-261028-sxux2ujo	234	7	2012	2012	CD
cord-261028-sxux2ujo	234	8	)	)	-RRB-
cord-261028-sxux2ujo	234	9	.	.	.
cord-261028-sxux2ujo	235	1	Normally	normally	RB
cord-261028-sxux2ujo	235	2	intracellular	intracellular	JJ
cord-261028-sxux2ujo	235	3	and	and	CC
cord-261028-sxux2ujo	235	4	out	out	IN
cord-261028-sxux2ujo	235	5	of	of	IN
cord-261028-sxux2ujo	235	6	the	the	DT
cord-261028-sxux2ujo	235	7	reach	reach	NN
cord-261028-sxux2ujo	235	8	of	of	IN
cord-261028-sxux2ujo	235	9	DCs	dc	NNS
cord-261028-sxux2ujo	235	10	under	under	IN
cord-261028-sxux2ujo	235	11	physiological	physiological	JJ
cord-261028-sxux2ujo	235	12	conditions	condition	NNS
cord-261028-sxux2ujo	235	13	,	,	,
cord-261028-sxux2ujo	235	14	these	these	DT
cord-261028-sxux2ujo	235	15	DAMPs	damp	NNS
cord-261028-sxux2ujo	235	16	serve	serve	VBP
cord-261028-sxux2ujo	235	17	as	as	IN
cord-261028-sxux2ujo	235	18	a	a	DT
cord-261028-sxux2ujo	235	19	danger	danger	NN
cord-261028-sxux2ujo	235	20	signal	signal	NN
cord-261028-sxux2ujo	235	21	when	when	WRB
cord-261028-sxux2ujo	235	22	released	release	VBN
cord-261028-sxux2ujo	235	23	into	into	IN
cord-261028-sxux2ujo	235	24	the	the	DT
cord-261028-sxux2ujo	235	25	extracellular	extracellular	JJ
cord-261028-sxux2ujo	235	26	milieu	milieu	NN
cord-261028-sxux2ujo	235	27	by	by	IN
cord-261028-sxux2ujo	235	28	stressed	stressed	JJ
cord-261028-sxux2ujo	235	29	or	or	CC
cord-261028-sxux2ujo	235	30	dying	die	VBG
cord-261028-sxux2ujo	235	31	cancer	cancer	NN
cord-261028-sxux2ujo	235	32	cells	cell	NNS
cord-261028-sxux2ujo	235	33	.	.	.
cord-261028-sxux2ujo	236	1	When	when	WRB
cord-261028-sxux2ujo	236	2	DAMPs	damp	NNS
cord-261028-sxux2ujo	236	3	are	be	VBP
cord-261028-sxux2ujo	236	4	accessible	accessible	JJ
cord-261028-sxux2ujo	236	5	to	to	IN
cord-261028-sxux2ujo	236	6	DCs	DCs	NNP
cord-261028-sxux2ujo	236	7	,	,	,
cord-261028-sxux2ujo	236	8	their	-PRON-	PRP$
cord-261028-sxux2ujo	236	9	presence	presence	NN
cord-261028-sxux2ujo	236	10	signifies	signify	VBZ
cord-261028-sxux2ujo	236	11	the	the	DT
cord-261028-sxux2ujo	236	12	loss	loss	NN
cord-261028-sxux2ujo	236	13	of	of	IN
cord-261028-sxux2ujo	236	14	integrity	integrity	NN
cord-261028-sxux2ujo	236	15	of	of	IN
cord-261028-sxux2ujo	236	16	the	the	DT
cord-261028-sxux2ujo	236	17	cell	cell	NN
cord-261028-sxux2ujo	236	18	membrane	membrane	NN
cord-261028-sxux2ujo	236	19	,	,	,
cord-261028-sxux2ujo	236	20	suggestive	suggestive	JJ
cord-261028-sxux2ujo	236	21	of	of	IN
cord-261028-sxux2ujo	236	22	tissue	tissue	NN
cord-261028-sxux2ujo	236	23	damage	damage	NN
cord-261028-sxux2ujo	236	24	caused	cause	VBN
cord-261028-sxux2ujo	236	25	by	by	IN
cord-261028-sxux2ujo	236	26	noxious	noxious	JJ
cord-261028-sxux2ujo	236	27	origins	origin	NNS
cord-261028-sxux2ujo	236	28	such	such	JJ
cord-261028-sxux2ujo	236	29	as	as	IN
cord-261028-sxux2ujo	236	30	infection	infection	NN
cord-261028-sxux2ujo	236	31	,	,	,
cord-261028-sxux2ujo	236	32	mechanical	mechanical	JJ
cord-261028-sxux2ujo	236	33	injury	injury	NN
cord-261028-sxux2ujo	236	34	,	,	,
cord-261028-sxux2ujo	236	35	or	or	CC
cord-261028-sxux2ujo	236	36	hypoxia	hypoxia	NN
cord-261028-sxux2ujo	236	37	.	.	.
cord-261028-sxux2ujo	237	1	In	in	IN
cord-261028-sxux2ujo	237	2	a	a	DT
cord-261028-sxux2ujo	237	3	cancer	cancer	NN
cord-261028-sxux2ujo	237	4	vaccination	vaccination	NN
cord-261028-sxux2ujo	237	5	animal	animal	NN
cord-261028-sxux2ujo	237	6	model	model	NN
cord-261028-sxux2ujo	237	7	,	,	,
cord-261028-sxux2ujo	237	8	TLR4	TLR4	NNP
cord-261028-sxux2ujo	237	9	and	and	CC
cord-261028-sxux2ujo	237	10	its	-PRON-	PRP$
cord-261028-sxux2ujo	237	11	downstream	downstream	JJ
cord-261028-sxux2ujo	237	12	signaling	signal	VBG
cord-261028-sxux2ujo	237	13	adaptor	adaptor	NN
cord-261028-sxux2ujo	237	14	MyD88	MyD88	NNS
cord-261028-sxux2ujo	237	15	have	have	VBP
cord-261028-sxux2ujo	237	16	been	be	VBN
cord-261028-sxux2ujo	237	17	implicated	implicate	VBN
cord-261028-sxux2ujo	237	18	in	in	IN
cord-261028-sxux2ujo	237	19	the	the	DT
cord-261028-sxux2ujo	237	20	immune	immune	JJ
cord-261028-sxux2ujo	237	21	response	response	NN
cord-261028-sxux2ujo	237	22	to	to	IN
cord-261028-sxux2ujo	237	23	cancers	cancer	NNS
cord-261028-sxux2ujo	237	24	induced	induce	VBN
cord-261028-sxux2ujo	237	25	by	by	IN
cord-261028-sxux2ujo	237	26	radiation	radiation	NN
cord-261028-sxux2ujo	237	27	and	and	CC
cord-261028-sxux2ujo	237	28	certain	certain	JJ
cord-261028-sxux2ujo	237	29	chemotherapies	chemotherapy	NNS
cord-261028-sxux2ujo	237	30	,	,	,
cord-261028-sxux2ujo	237	31	however	however	RB
cord-261028-sxux2ujo	237	32	in	in	IN
cord-261028-sxux2ujo	237	33	other	other	JJ
cord-261028-sxux2ujo	237	34	models	model	NNS
cord-261028-sxux2ujo	237	35	TLR4	TLR4	NNP
cord-261028-sxux2ujo	237	36	/	/	SYM
cord-261028-sxux2ujo	237	37	MyD88	MyD88	NNP
cord-261028-sxux2ujo	237	38	was	be	VBD
cord-261028-sxux2ujo	237	39	not	not	RB
cord-261028-sxux2ujo	237	40	found	find	VBN
cord-261028-sxux2ujo	237	41	to	to	TO
cord-261028-sxux2ujo	237	42	be	be	VB
cord-261028-sxux2ujo	237	43	necessary	necessary	JJ
cord-261028-sxux2ujo	237	44	or	or	CC
cord-261028-sxux2ujo	237	45	sufficient	sufficient	JJ
cord-261028-sxux2ujo	237	46	for	for	IN
cord-261028-sxux2ujo	237	47	the	the	DT
cord-261028-sxux2ujo	237	48	development	development	NN
cord-261028-sxux2ujo	237	49	of	of	IN
cord-261028-sxux2ujo	237	50	an	an	DT
cord-261028-sxux2ujo	237	51	immune	immune	JJ
cord-261028-sxux2ujo	237	52	response	response	NN
cord-261028-sxux2ujo	237	53	to	to	IN
cord-261028-sxux2ujo	237	54	cancers	cancer	NNS
cord-261028-sxux2ujo	237	55	.	.	.
cord-261028-sxux2ujo	238	1	More	more	RBR
cord-261028-sxux2ujo	238	2	recently	recently	RB
cord-261028-sxux2ujo	238	3	,	,	,
cord-261028-sxux2ujo	238	4	type	type	NN
cord-261028-sxux2ujo	238	5	I	-PRON-	PRP
cord-261028-sxux2ujo	238	6	IFN	IFN	NNP
cord-261028-sxux2ujo	238	7	production	production	NN
cord-261028-sxux2ujo	238	8	and	and	CC
cord-261028-sxux2ujo	238	9	signaling	signal	VBG
cord-261028-sxux2ujo	238	10	through	through	IN
cord-261028-sxux2ujo	238	11	the	the	DT
cord-261028-sxux2ujo	238	12	STING	sting	NN
cord-261028-sxux2ujo	238	13	pathway	pathway	NN
cord-261028-sxux2ujo	238	14	has	have	VBZ
cord-261028-sxux2ujo	238	15	been	be	VBN
cord-261028-sxux2ujo	238	16	identified	identify	VBN
cord-261028-sxux2ujo	238	17	as	as	IN
cord-261028-sxux2ujo	238	18	having	have	VBG
cord-261028-sxux2ujo	238	19	an	an	DT
cord-261028-sxux2ujo	238	20	essential	essential	JJ
cord-261028-sxux2ujo	238	21	role	role	NN
cord-261028-sxux2ujo	238	22	in	in	IN
cord-261028-sxux2ujo	238	23	the	the	DT
cord-261028-sxux2ujo	238	24	development	development	NN
cord-261028-sxux2ujo	238	25	of	of	IN
cord-261028-sxux2ujo	238	26	anti	anti	JJ
cord-261028-sxux2ujo	238	27	-	-	JJ
cord-261028-sxux2ujo	238	28	tumor	tumor	JJ
cord-261028-sxux2ujo	238	29	immunity	immunity	NN
cord-261028-sxux2ujo	238	30	in	in	IN
cord-261028-sxux2ujo	238	31	response	response	NN
cord-261028-sxux2ujo	238	32	to	to	IN
cord-261028-sxux2ujo	238	33	tumor	tumor	NN
cord-261028-sxux2ujo	238	34	derived	derive	VBN
cord-261028-sxux2ujo	238	35	DNA	dna	NN
cord-261028-sxux2ujo	238	36	.	.	.
cord-261028-sxux2ujo	239	1	Protection	protection	NN
cord-261028-sxux2ujo	239	2	of	of	IN
cord-261028-sxux2ujo	239	3	the	the	DT
cord-261028-sxux2ujo	239	4	integrity	integrity	NN
cord-261028-sxux2ujo	239	5	of	of	IN
cord-261028-sxux2ujo	239	6	genetic	genetic	JJ
cord-261028-sxux2ujo	239	7	information	information	NN
cord-261028-sxux2ujo	239	8	encoded	encode	VBN
cord-261028-sxux2ujo	239	9	in	in	IN
cord-261028-sxux2ujo	239	10	DNA	DNA	NNP
cord-261028-sxux2ujo	239	11	has	have	VBZ
cord-261028-sxux2ujo	239	12	been	be	VBN
cord-261028-sxux2ujo	239	13	a	a	DT
cord-261028-sxux2ujo	239	14	primary	primary	JJ
cord-261028-sxux2ujo	239	15	prerogative	prerogative	NN
cord-261028-sxux2ujo	239	16	of	of	IN
cord-261028-sxux2ujo	239	17	living	live	VBG
cord-261028-sxux2ujo	239	18	organisms	organism	NNS
cord-261028-sxux2ujo	239	19	since	since	IN
cord-261028-sxux2ujo	239	20	their	-PRON-	PRP$
cord-261028-sxux2ujo	239	21	inception	inception	NN
cord-261028-sxux2ujo	239	22	,	,	,
cord-261028-sxux2ujo	239	23	and	and	CC
cord-261028-sxux2ujo	239	24	sensing	sense	VBG
cord-261028-sxux2ujo	239	25	threats	threat	NNS
cord-261028-sxux2ujo	239	26	in	in	IN
cord-261028-sxux2ujo	239	27	the	the	DT
cord-261028-sxux2ujo	239	28	form	form	NN
cord-261028-sxux2ujo	239	29	of	of	IN
cord-261028-sxux2ujo	239	30	DNA	dna	NN
cord-261028-sxux2ujo	239	31	damage	damage	NN
cord-261028-sxux2ujo	239	32	through	through	IN
cord-261028-sxux2ujo	239	33	radiation	radiation	NN
cord-261028-sxux2ujo	239	34	exposure	exposure	NN
cord-261028-sxux2ujo	239	35	,	,	,
cord-261028-sxux2ujo	239	36	oxidative	oxidative	JJ
cord-261028-sxux2ujo	239	37	stress	stress	NN
cord-261028-sxux2ujo	239	38	,	,	,
cord-261028-sxux2ujo	239	39	and	and	CC
cord-261028-sxux2ujo	239	40	viral	viral	JJ
cord-261028-sxux2ujo	239	41	infection	infection	NN
cord-261028-sxux2ujo	239	42	is	be	VBZ
cord-261028-sxux2ujo	239	43	essential	essential	JJ
cord-261028-sxux2ujo	239	44	to	to	IN
cord-261028-sxux2ujo	239	45	maintaining	maintain	VBG
cord-261028-sxux2ujo	239	46	and	and	CC
cord-261028-sxux2ujo	239	47	continuing	continue	VBG
cord-261028-sxux2ujo	239	48	the	the	DT
cord-261028-sxux2ujo	239	49	line	line	NN
cord-261028-sxux2ujo	239	50	of	of	IN
cord-261028-sxux2ujo	239	51	genetic	genetic	JJ
cord-261028-sxux2ujo	239	52	information	information	NN
cord-261028-sxux2ujo	239	53	.	.	.
cord-261028-sxux2ujo	240	1	Cells	cell	NNS
cord-261028-sxux2ujo	240	2	have	have	VBP
cord-261028-sxux2ujo	240	3	maintained	maintain	VBN
cord-261028-sxux2ujo	240	4	this	this	DT
cord-261028-sxux2ujo	240	5	potential	potential	NN
cord-261028-sxux2ujo	240	6	,	,	,
cord-261028-sxux2ujo	240	7	especially	especially	RB
cord-261028-sxux2ujo	240	8	in	in	IN
cord-261028-sxux2ujo	240	9	APCs	apc	NNS
cord-261028-sxux2ujo	240	10	such	such	JJ
cord-261028-sxux2ujo	240	11	as	as	IN
cord-261028-sxux2ujo	240	12	DCs	DCs	NNP
cord-261028-sxux2ujo	240	13	,	,	,
cord-261028-sxux2ujo	240	14	which	which	WDT
cord-261028-sxux2ujo	240	15	respond	respond	VBP
cord-261028-sxux2ujo	240	16	to	to	IN
cord-261028-sxux2ujo	240	17	DNA	dna	NN
cord-261028-sxux2ujo	240	18	damage	damage	NN
cord-261028-sxux2ujo	240	19	and	and	CC
cord-261028-sxux2ujo	240	20	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	240	21	DNA	dna	NN
cord-261028-sxux2ujo	240	22	by	by	IN
cord-261028-sxux2ujo	240	23	producing	produce	VBG
cord-261028-sxux2ujo	240	24	type	type	NN
cord-261028-sxux2ujo	240	25	I	-PRON-	PRP
cord-261028-sxux2ujo	240	26	IFN	IFN	NNP
cord-261028-sxux2ujo	240	27	.	.	.
cord-261028-sxux2ujo	241	1	In	in	IN
cord-261028-sxux2ujo	241	2	addition	addition	NN
cord-261028-sxux2ujo	241	3	to	to	IN
cord-261028-sxux2ujo	241	4	the	the	DT
cord-261028-sxux2ujo	241	5	recognition	recognition	NN
cord-261028-sxux2ujo	241	6	of	of	IN
cord-261028-sxux2ujo	241	7	dsDNA	dsdna	RB
cord-261028-sxux2ujo	241	8	,	,	,
cord-261028-sxux2ujo	241	9	several	several	JJ
cord-261028-sxux2ujo	241	10	reports	report	NNS
cord-261028-sxux2ujo	241	11	suggest	suggest	VBP
cord-261028-sxux2ujo	241	12	that	that	IN
cord-261028-sxux2ujo	241	13	STING	sting	NN
cord-261028-sxux2ujo	241	14	can	can	MD
cord-261028-sxux2ujo	241	15	promote	promote	VB
cord-261028-sxux2ujo	241	16	type	type	NN
cord-261028-sxux2ujo	242	1	I	-PRON-	PRP
cord-261028-sxux2ujo	242	2	IFN	IFN	NNP
cord-261028-sxux2ujo	242	3	production	production	NN
cord-261028-sxux2ujo	242	4	upon	upon	IN
cord-261028-sxux2ujo	242	5	RNA	rna	NN
cord-261028-sxux2ujo	242	6	-	-	HYPH
cord-261028-sxux2ujo	242	7	virus	virus	NN
cord-261028-sxux2ujo	242	8	infection	infection	NN
cord-261028-sxux2ujo	242	9	through	through	IN
cord-261028-sxux2ujo	242	10	its	-PRON-	PRP$
cord-261028-sxux2ujo	242	11	interaction	interaction	NN
cord-261028-sxux2ujo	242	12	with	with	IN
cord-261028-sxux2ujo	242	13	the	the	DT
cord-261028-sxux2ujo	242	14	RNA	RNA	NNP
cord-261028-sxux2ujo	242	15	sensing	sensing	NN
cord-261028-sxux2ujo	242	16	pathway	pathway	NN
cord-261028-sxux2ujo	242	17	components	component	NNS
cord-261028-sxux2ujo	242	18	RIG1	RIG1	NNP
cord-261028-sxux2ujo	242	19	and	and	CC
cord-261028-sxux2ujo	242	20	MAVS	MAVS	NNP
cord-261028-sxux2ujo	243	1	(	(	-LRB-
cord-261028-sxux2ujo	243	2	Nazmi	Nazmi	NNP
cord-261028-sxux2ujo	243	3	et	et	NNP
cord-261028-sxux2ujo	243	4	al	al	NNP
cord-261028-sxux2ujo	243	5	.	.	NNP
cord-261028-sxux2ujo	243	6	,	,	,
cord-261028-sxux2ujo	243	7	2012	2012	CD
cord-261028-sxux2ujo	243	8	;	;	:
cord-261028-sxux2ujo	243	9	Sun	Sun	NNP
cord-261028-sxux2ujo	243	10	et	et	NNP
cord-261028-sxux2ujo	243	11	al	al	NNP
cord-261028-sxux2ujo	243	12	.	.	NNP
cord-261028-sxux2ujo	243	13	,	,	,
cord-261028-sxux2ujo	243	14	2012	2012	CD
cord-261028-sxux2ujo	243	15	)	)	-RRB-
cord-261028-sxux2ujo	243	16	.	.	.
cord-261028-sxux2ujo	244	1	However	however	RB
cord-261028-sxux2ujo	244	2	,	,	,
cord-261028-sxux2ujo	244	3	evidence	evidence	NN
cord-261028-sxux2ujo	244	4	that	that	IN
cord-261028-sxux2ujo	244	5	the	the	DT
cord-261028-sxux2ujo	244	6	STING	sting	NN
cord-261028-sxux2ujo	244	7	pathway	pathway	NN
cord-261028-sxux2ujo	244	8	in	in	IN
cord-261028-sxux2ujo	244	9	DCs	DCs	NNP
cord-261028-sxux2ujo	244	10	is	be	VBZ
cord-261028-sxux2ujo	244	11	activated	activate	VBN
cord-261028-sxux2ujo	244	12	by	by	IN
cord-261028-sxux2ujo	244	13	RNA	RNA	NNP
cord-261028-sxux2ujo	244	14	upon	upon	IN
cord-261028-sxux2ujo	244	15	uptake	uptake	NN
cord-261028-sxux2ujo	244	16	of	of	IN
cord-261028-sxux2ujo	244	17	dead	dead	JJ
cord-261028-sxux2ujo	244	18	or	or	CC
cord-261028-sxux2ujo	244	19	dying	die	VBG
cord-261028-sxux2ujo	244	20	cells	cell	NNS
cord-261028-sxux2ujo	244	21	is	be	VBZ
cord-261028-sxux2ujo	244	22	not	not	RB
cord-261028-sxux2ujo	244	23	available	available	JJ
cord-261028-sxux2ujo	244	24	.	.	.
cord-261028-sxux2ujo	245	1	Type	type	NN
cord-261028-sxux2ujo	246	1	I	-PRON-	PRP
cord-261028-sxux2ujo	246	2	IFN	IFN	NNP
cord-261028-sxux2ujo	246	3	signaling	signal	VBG
cord-261028-sxux2ujo	246	4	in	in	IN
cord-261028-sxux2ujo	246	5	DCs	DCs	NNP
cord-261028-sxux2ujo	246	6	has	have	VBZ
cord-261028-sxux2ujo	246	7	been	be	VBN
cord-261028-sxux2ujo	246	8	shown	show	VBN
cord-261028-sxux2ujo	246	9	to	to	TO
cord-261028-sxux2ujo	246	10	promote	promote	VB
cord-261028-sxux2ujo	246	11	their	-PRON-	PRP$
cord-261028-sxux2ujo	246	12	capacity	capacity	NN
cord-261028-sxux2ujo	246	13	to	to	IN
cord-261028-sxux2ujo	246	14	prime	prime	NN
cord-261028-sxux2ujo	246	15	and	and	CC
cord-261028-sxux2ujo	246	16	crossprime	crossprime	NNP
cord-261028-sxux2ujo	246	17	T	t	NN
cord-261028-sxux2ujo	246	18	cells	cell	NNS
cord-261028-sxux2ujo	246	19	in	in	IN
cord-261028-sxux2ujo	246	20	several	several	JJ
cord-261028-sxux2ujo	246	21	ways	way	NNS
cord-261028-sxux2ujo	246	22	.	.	.
cord-261028-sxux2ujo	247	1	Type	type	NN
cord-261028-sxux2ujo	247	2	I	-PRON-	PRP
cord-261028-sxux2ujo	247	3	IFNs	ifn	NNS
cord-261028-sxux2ujo	247	4	are	be	VBP
cord-261028-sxux2ujo	247	5	cytokines	cytokine	NNS
cord-261028-sxux2ujo	247	6	with	with	IN
cord-261028-sxux2ujo	247	7	potent	potent	JJ
cord-261028-sxux2ujo	247	8	activity	activity	NN
cord-261028-sxux2ujo	247	9	on	on	IN
cord-261028-sxux2ujo	247	10	DC	DC	NNP
cord-261028-sxux2ujo	247	11	phenotype	phenotype	NN
cord-261028-sxux2ujo	247	12	and	and	CC
cord-261028-sxux2ujo	247	13	function	function	VB
cord-261028-sxux2ujo	247	14	through	through	IN
cord-261028-sxux2ujo	247	15	their	-PRON-	PRP$
cord-261028-sxux2ujo	247	16	effects	effect	NNS
cord-261028-sxux2ujo	247	17	on	on	IN
cord-261028-sxux2ujo	247	18	all	all	DT
cord-261028-sxux2ujo	247	19	three	three	CD
cord-261028-sxux2ujo	247	20	signals	signal	NNS
cord-261028-sxux2ujo	247	21	needed	need	VBN
cord-261028-sxux2ujo	247	22	to	to	TO
cord-261028-sxux2ujo	247	23	generate	generate	VB
cord-261028-sxux2ujo	247	24	a	a	DT
cord-261028-sxux2ujo	247	25	robust	robust	JJ
cord-261028-sxux2ujo	247	26	T	T	NNP
cord-261028-sxux2ujo	247	27	cell	cell	NN
cord-261028-sxux2ujo	247	28	response	response	NN
cord-261028-sxux2ujo	247	29	.	.	.
cord-261028-sxux2ujo	248	1	Type	type	NN
cord-261028-sxux2ujo	248	2	I	-PRON-	PRP
cord-261028-sxux2ujo	248	3	IFNs	ifn	NNS
cord-261028-sxux2ujo	248	4	are	be	VBP
cord-261028-sxux2ujo	248	5	a	a	DT
cord-261028-sxux2ujo	248	6	collection	collection	NN
cord-261028-sxux2ujo	248	7	of	of	IN
cord-261028-sxux2ujo	248	8	13	13	CD
cord-261028-sxux2ujo	248	9	IFNα	ifnα	JJ
cord-261028-sxux2ujo	248	10	proteins	protein	NNS
cord-261028-sxux2ujo	248	11	,	,	,
cord-261028-sxux2ujo	248	12	as	as	RB
cord-261028-sxux2ujo	248	13	well	well	RB
cord-261028-sxux2ujo	248	14	as	as	IN
cord-261028-sxux2ujo	248	15	IFNβ	IFNβ	NNS
cord-261028-sxux2ujo	248	16	,	,	,
cord-261028-sxux2ujo	248	17	IFNκ	IFNκ	NNP
cord-261028-sxux2ujo	248	18	,	,	,
cord-261028-sxux2ujo	248	19	and	and	CC
cord-261028-sxux2ujo	248	20	IFNω	IFNω	NNPS
cord-261028-sxux2ujo	248	21	,	,	,
cord-261028-sxux2ujo	248	22	all	all	DT
cord-261028-sxux2ujo	248	23	of	of	IN
cord-261028-sxux2ujo	248	24	which	which	WDT
cord-261028-sxux2ujo	248	25	signal	signal	VBP
cord-261028-sxux2ujo	248	26	through	through	IN
cord-261028-sxux2ujo	248	27	the	the	DT
cord-261028-sxux2ujo	248	28	common	common	JJ
cord-261028-sxux2ujo	248	29	interferon	interferon	NN
cord-261028-sxux2ujo	248	30	(	(	-LRB-
cord-261028-sxux2ujo	248	31	α	α	NN
cord-261028-sxux2ujo	248	32	and	and	CC
cord-261028-sxux2ujo	248	33	β	β	NN
cord-261028-sxux2ujo	248	34	)	)	-RRB-
cord-261028-sxux2ujo	248	35	receptor	receptor	NN
cord-261028-sxux2ujo	248	36	(	(	-LRB-
cord-261028-sxux2ujo	248	37	IFNAR	IFNAR	NNP
cord-261028-sxux2ujo	248	38	)	)	-RRB-
cord-261028-sxux2ujo	248	39	.	.	.
cord-261028-sxux2ujo	249	1	Essentially	essentially	RB
cord-261028-sxux2ujo	249	2	all	all	DT
cord-261028-sxux2ujo	249	3	nucleated	nucleated	JJ
cord-261028-sxux2ujo	249	4	cells	cell	NNS
cord-261028-sxux2ujo	249	5	express	express	VBP
cord-261028-sxux2ujo	249	6	IFNAR	IFNAR	NNP
cord-261028-sxux2ujo	249	7	,	,	,
cord-261028-sxux2ujo	249	8	a	a	DT
cord-261028-sxux2ujo	249	9	heterodimer	heterodimer	NN
cord-261028-sxux2ujo	249	10	including	include	VBG
cord-261028-sxux2ujo	249	11	the	the	DT
cord-261028-sxux2ujo	249	12	two	two	CD
cord-261028-sxux2ujo	249	13	distinct	distinct	JJ
cord-261028-sxux2ujo	249	14	subunits	subunit	NNS
cord-261028-sxux2ujo	249	15	IFNAR1	ifnar1	NN
cord-261028-sxux2ujo	249	16	and	and	CC
cord-261028-sxux2ujo	249	17	IFNAR2	IFNAR2	NNP
cord-261028-sxux2ujo	249	18	.	.	.
cord-261028-sxux2ujo	250	1	Binding	bind	VBG
cord-261028-sxux2ujo	250	2	of	of	IN
cord-261028-sxux2ujo	250	3	IFNs	ifn	NNS
cord-261028-sxux2ujo	250	4	to	to	IN
cord-261028-sxux2ujo	250	5	their	-PRON-	PRP$
cord-261028-sxux2ujo	250	6	receptors	receptor	NNS
cord-261028-sxux2ujo	250	7	leads	lead	VBZ
cord-261028-sxux2ujo	250	8	to	to	IN
cord-261028-sxux2ujo	250	9	dimerization	dimerization	NN
cord-261028-sxux2ujo	250	10	of	of	IN
cord-261028-sxux2ujo	250	11	the	the	DT
cord-261028-sxux2ujo	250	12	two	two	CD
cord-261028-sxux2ujo	250	13	subunits	subunit	NNS
cord-261028-sxux2ujo	250	14	,	,	,
cord-261028-sxux2ujo	250	15	resulting	result	VBG
cord-261028-sxux2ujo	250	16	in	in	IN
cord-261028-sxux2ujo	250	17	auto	auto	NN
cord-261028-sxux2ujo	250	18	phosphorylation	phosphorylation	NN
cord-261028-sxux2ujo	250	19	of	of	IN
cord-261028-sxux2ujo	250	20	tyrosine	tyrosine	NN
cord-261028-sxux2ujo	250	21	kinase	kinase	NN
cord-261028-sxux2ujo	250	22	2	2	CD
cord-261028-sxux2ujo	250	23	(	(	-LRB-
cord-261028-sxux2ujo	250	24	TYK2	TYK2	NNP
cord-261028-sxux2ujo	250	25	)	)	-RRB-
cord-261028-sxux2ujo	250	26	and	and	CC
cord-261028-sxux2ujo	250	27	Janus	Janus	NNP
cord-261028-sxux2ujo	250	28	activated	activate	VBD
cord-261028-sxux2ujo	250	29	kinase	kinase	NN
cord-261028-sxux2ujo	250	30	(	(	-LRB-
cord-261028-sxux2ujo	250	31	JAK	JAK	NNP
cord-261028-sxux2ujo	250	32	)	)	-RRB-
cord-261028-sxux2ujo	250	33	2	2	CD
cord-261028-sxux2ujo	250	34	that	that	WDT
cord-261028-sxux2ujo	250	35	activate	activate	VBP
cord-261028-sxux2ujo	250	36	the	the	DT
cord-261028-sxux2ujo	250	37	signal	signal	NN
cord-261028-sxux2ujo	250	38	transducer	transducer	NN
cord-261028-sxux2ujo	250	39	and	and	CC
cord-261028-sxux2ujo	250	40	activator	activator	NN
cord-261028-sxux2ujo	250	41	of	of	IN
cord-261028-sxux2ujo	250	42	transcription	transcription	NN
cord-261028-sxux2ujo	250	43	(	(	-LRB-
cord-261028-sxux2ujo	250	44	STAT	stat	NN
cord-261028-sxux2ujo	250	45	)	)	-RRB-
cord-261028-sxux2ujo	251	1	1	1	CD
cord-261028-sxux2ujo	251	2	and	and	CC
cord-261028-sxux2ujo	251	3	2	2	CD
cord-261028-sxux2ujo	252	1	(	(	-LRB-
cord-261028-sxux2ujo	252	2	Theofilopoulos	Theofilopoulos	NNP
cord-261028-sxux2ujo	252	3	et	et	NNP
cord-261028-sxux2ujo	252	4	al	al	NNP
cord-261028-sxux2ujo	252	5	.	.	NNP
cord-261028-sxux2ujo	252	6	,	,	,
cord-261028-sxux2ujo	252	7	2005	2005	CD
cord-261028-sxux2ujo	252	8	)	)	-RRB-
cord-261028-sxux2ujo	252	9	.	.	.
cord-261028-sxux2ujo	253	1	The	the	DT
cord-261028-sxux2ujo	253	2	activated	activate	VBN
cord-261028-sxux2ujo	253	3	STAT	stat	NN
cord-261028-sxux2ujo	253	4	proteins	protein	NNS
cord-261028-sxux2ujo	253	5	dimerized	dimerize	VBD
cord-261028-sxux2ujo	253	6	and	and	CC
cord-261028-sxux2ujo	253	7	rapidly	rapidly	RB
cord-261028-sxux2ujo	253	8	translocate	translocate	VB
cord-261028-sxux2ujo	253	9	to	to	IN
cord-261028-sxux2ujo	253	10	the	the	DT
cord-261028-sxux2ujo	253	11	nucleus	nucleus	NN
cord-261028-sxux2ujo	253	12	where	where	WRB
cord-261028-sxux2ujo	253	13	they	-PRON-	PRP
cord-261028-sxux2ujo	253	14	bind	bind	VBP
cord-261028-sxux2ujo	253	15	IFN	IFN	NNP
cord-261028-sxux2ujo	253	16	-	-	HYPH
cord-261028-sxux2ujo	253	17	stimulated	stimulate	VBN
cord-261028-sxux2ujo	253	18	response	response	NN
cord-261028-sxux2ujo	253	19	elements	element	NNS
cord-261028-sxux2ujo	253	20	(	(	-LRB-
cord-261028-sxux2ujo	253	21	ISREs	ISREs	NNP
cord-261028-sxux2ujo	253	22	)	)	-RRB-
cord-261028-sxux2ujo	253	23	,	,	,
cord-261028-sxux2ujo	253	24	initiating	initiate	VBG
cord-261028-sxux2ujo	253	25	the	the	DT
cord-261028-sxux2ujo	253	26	transcription	transcription	NN
cord-261028-sxux2ujo	253	27	of	of	IN
cord-261028-sxux2ujo	253	28	hundreds	hundred	NNS
cord-261028-sxux2ujo	253	29	of	of	IN
cord-261028-sxux2ujo	253	30	IFN	IFN	NNP
cord-261028-sxux2ujo	253	31	-	-	HYPH
cord-261028-sxux2ujo	253	32	sensitive	sensitive	JJ
cord-261028-sxux2ujo	253	33	genes	gene	NNS
cord-261028-sxux2ujo	253	34	(	(	-LRB-
cord-261028-sxux2ujo	253	35	ISGs	ISGs	NNP
cord-261028-sxux2ujo	253	36	)	)	-RRB-
cord-261028-sxux2ujo	253	37	.	.	.
cord-261028-sxux2ujo	254	1	Type	type	NN
cord-261028-sxux2ujo	255	1	I	-PRON-	PRP
cord-261028-sxux2ujo	255	2	IFN	IFN	NNP
cord-261028-sxux2ujo	255	3	facilitates	facilitate	VBZ
cord-261028-sxux2ujo	255	4	cross	cross	NN
cord-261028-sxux2ujo	255	5	-	-	JJ
cord-261028-sxux2ujo	255	6	priming	priming	NN
cord-261028-sxux2ujo	255	7	by	by	IN
cord-261028-sxux2ujo	255	8	DCs	dc	NNS
cord-261028-sxux2ujo	255	9	through	through	IN
cord-261028-sxux2ujo	255	10	a	a	DT
cord-261028-sxux2ujo	255	11	variety	variety	NN
cord-261028-sxux2ujo	255	12	of	of	IN
cord-261028-sxux2ujo	255	13	mechanisms	mechanism	NNS
cord-261028-sxux2ujo	255	14	.	.	.
cord-261028-sxux2ujo	256	1	It	-PRON-	PRP
cord-261028-sxux2ujo	256	2	promotes	promote	VBZ
cord-261028-sxux2ujo	256	3	antigen	antigen	NN
cord-261028-sxux2ujo	256	4	persistence	persistence	NN
cord-261028-sxux2ujo	256	5	through	through	IN
cord-261028-sxux2ujo	256	6	the	the	DT
cord-261028-sxux2ujo	256	7	reduction	reduction	NN
cord-261028-sxux2ujo	256	8	of	of	IN
cord-261028-sxux2ujo	256	9	the	the	DT
cord-261028-sxux2ujo	256	10	endosomal	endosomal	JJ
cord-261028-sxux2ujo	256	11	-	-	HYPH
cord-261028-sxux2ujo	256	12	lysosomal	lysosomal	JJ
cord-261028-sxux2ujo	256	13	acidification	acidification	NN
cord-261028-sxux2ujo	256	14	rate	rate	NN
cord-261028-sxux2ujo	256	15	,	,	,
cord-261028-sxux2ujo	256	16	thus	thus	RB
cord-261028-sxux2ujo	256	17	facilitating	facilitate	VBG
cord-261028-sxux2ujo	256	18	the	the	DT
cord-261028-sxux2ujo	256	19	storage	storage	NN
cord-261028-sxux2ujo	256	20	of	of	IN
cord-261028-sxux2ujo	256	21	exogenously	exogenously	RB
cord-261028-sxux2ujo	256	22	acquired	acquire	VBN
cord-261028-sxux2ujo	256	23	cell	cell	NN
cord-261028-sxux2ujo	256	24	-	-	HYPH
cord-261028-sxux2ujo	256	25	associated	associate	VBN
cord-261028-sxux2ujo	256	26	antigens	antigen	NNS
cord-261028-sxux2ujo	256	27	in	in	IN
cord-261028-sxux2ujo	256	28	RAB5	RAB5	NNP
cord-261028-sxux2ujo	257	1	+	+	CC
cord-261028-sxux2ujo	258	1	and	and	CC
cord-261028-sxux2ujo	258	2	RAB11	RAB11	NNP
cord-261028-sxux2ujo	258	3	+	+	-RRB-
cord-261028-sxux2ujo	258	4	compartments	compartment	NNS
cord-261028-sxux2ujo	258	5	(	(	-LRB-
cord-261028-sxux2ujo	258	6	Thacker	Thacker	NNP
cord-261028-sxux2ujo	258	7	and	and	CC
cord-261028-sxux2ujo	258	8	Janssen	Janssen	NNP
cord-261028-sxux2ujo	258	9	,	,	,
cord-261028-sxux2ujo	258	10	2012	2012	CD
cord-261028-sxux2ujo	258	11	;	;	:
cord-261028-sxux2ujo	259	1	Lorenzi	Lorenzi	NNP
cord-261028-sxux2ujo	259	2	et	et	NNP
cord-261028-sxux2ujo	259	3	al	al	NNP
cord-261028-sxux2ujo	259	4	.	.	NNP
cord-261028-sxux2ujo	259	5	,	,	,
cord-261028-sxux2ujo	259	6	2011	2011	CD
cord-261028-sxux2ujo	259	7	)	)	-RRB-
cord-261028-sxux2ujo	259	8	.	.	.
cord-261028-sxux2ujo	260	1	Furthermore	furthermore	RB
cord-261028-sxux2ujo	260	2	,	,	,
cord-261028-sxux2ujo	260	3	type	type	NN
cord-261028-sxux2ujo	260	4	I	-PRON-	PRP
cord-261028-sxux2ujo	260	5	IFN	IFN	NNP
cord-261028-sxux2ujo	260	6	promotes	promote	VBZ
cord-261028-sxux2ujo	260	7	transcription	transcription	NN
cord-261028-sxux2ujo	260	8	and	and	CC
cord-261028-sxux2ujo	260	9	translation	translation	NN
cord-261028-sxux2ujo	260	10	of	of	IN
cord-261028-sxux2ujo	260	11	the	the	DT
cord-261028-sxux2ujo	260	12	immunoproteasome	immunoproteasome	NNP
cord-261028-sxux2ujo	260	13	subunits	subunit	NNS
cord-261028-sxux2ujo	260	14	β1i	β1i	NNP
cord-261028-sxux2ujo	260	15	(	(	-LRB-
cord-261028-sxux2ujo	260	16	LMP2	LMP2	NNP
cord-261028-sxux2ujo	260	17	)	)	-RRB-
cord-261028-sxux2ujo	260	18	,	,	,
cord-261028-sxux2ujo	260	19	β2i	β2i	NNP
cord-261028-sxux2ujo	260	20	(	(	-LRB-
cord-261028-sxux2ujo	260	21	MECL-1	MECL-1	NNP
cord-261028-sxux2ujo	260	22	)	)	-RRB-
cord-261028-sxux2ujo	260	23	,	,	,
cord-261028-sxux2ujo	260	24	and	and	CC
cord-261028-sxux2ujo	260	25	β5i	β5i	JJ
cord-261028-sxux2ujo	260	26	(	(	-LRB-
cord-261028-sxux2ujo	260	27	LMP7	LMP7	NNP
cord-261028-sxux2ujo	260	28	)	)	-RRB-
cord-261028-sxux2ujo	261	1	(	(	-LRB-
cord-261028-sxux2ujo	261	2	Shin	Shin	NNP
cord-261028-sxux2ujo	261	3	et	et	NNP
cord-261028-sxux2ujo	261	4	al	al	NNP
cord-261028-sxux2ujo	261	5	.	.	NNP
cord-261028-sxux2ujo	261	6	,	,	,
cord-261028-sxux2ujo	261	7	2006	2006	CD
cord-261028-sxux2ujo	261	8	;	;	:
cord-261028-sxux2ujo	261	9	Shin	Shin	NNP
cord-261028-sxux2ujo	261	10	et	et	NNP
cord-261028-sxux2ujo	261	11	al	al	NNP
cord-261028-sxux2ujo	261	12	.	.	NNP
cord-261028-sxux2ujo	261	13	,	,	,
cord-261028-sxux2ujo	261	14	2007	2007	CD
cord-261028-sxux2ujo	261	15	)	)	-RRB-
cord-261028-sxux2ujo	261	16	,	,	,
cord-261028-sxux2ujo	261	17	which	which	WDT
cord-261028-sxux2ujo	261	18	modifies	modify	VBZ
cord-261028-sxux2ujo	261	19	the	the	DT
cord-261028-sxux2ujo	261	20	peptidase	peptidase	NN
cord-261028-sxux2ujo	261	21	activity	activity	NN
cord-261028-sxux2ujo	261	22	of	of	IN
cord-261028-sxux2ujo	261	23	the	the	DT
cord-261028-sxux2ujo	261	24	constitutive	constitutive	JJ
cord-261028-sxux2ujo	261	25	proteasome	proteasome	NN
cord-261028-sxux2ujo	261	26	,	,	,
cord-261028-sxux2ujo	261	27	changing	change	VBG
cord-261028-sxux2ujo	261	28	the	the	DT
cord-261028-sxux2ujo	261	29	repertoire	repertoire	NN
cord-261028-sxux2ujo	261	30	of	of	IN
cord-261028-sxux2ujo	261	31	peptides	peptide	NNS
cord-261028-sxux2ujo	261	32	for	for	IN
cord-261028-sxux2ujo	261	33	binding	binding	NN
cord-261028-sxux2ujo	261	34	and	and	CC
cord-261028-sxux2ujo	261	35	presentation	presentation	NN
cord-261028-sxux2ujo	261	36	on	on	IN
cord-261028-sxux2ujo	261	37	MHCI	MHCI	NNP
cord-261028-sxux2ujo	261	38	.	.	.
cord-261028-sxux2ujo	262	1	In	in	IN
cord-261028-sxux2ujo	262	2	addition	addition	NN
cord-261028-sxux2ujo	262	3	,	,	,
cord-261028-sxux2ujo	262	4	IFNα	IFNα	NNP
cord-261028-sxux2ujo	262	5	treatment	treatment	NN
cord-261028-sxux2ujo	262	6	promotes	promote	VBZ
cord-261028-sxux2ujo	262	7	localization	localization	NN
cord-261028-sxux2ujo	262	8	of	of	IN
cord-261028-sxux2ujo	262	9	MHCI	MHCI	NNP
cord-261028-sxux2ujo	262	10	molecules	molecule	NNS
cord-261028-sxux2ujo	262	11	to	to	IN
cord-261028-sxux2ujo	262	12	antigen	antigen	NN
cord-261028-sxux2ujo	262	13	storage	storage	NN
cord-261028-sxux2ujo	262	14	compartments	compartment	NNS
cord-261028-sxux2ujo	262	15	in	in	IN
cord-261028-sxux2ujo	262	16	DCs	DCs	NNP
cord-261028-sxux2ujo	262	17	,	,	,
cord-261028-sxux2ujo	262	18	enhancing	enhance	VBG
cord-261028-sxux2ujo	262	19	antigen	antigen	NN
cord-261028-sxux2ujo	262	20	presentation	presentation	NN
cord-261028-sxux2ujo	262	21	(	(	-LRB-
cord-261028-sxux2ujo	262	22	Spadaro	Spadaro	NNP
cord-261028-sxux2ujo	262	23	et	et	NNP
cord-261028-sxux2ujo	262	24	al	al	NNP
cord-261028-sxux2ujo	262	25	.	.	NNP
cord-261028-sxux2ujo	262	26	,	,	,
cord-261028-sxux2ujo	262	27	2012	2012	CD
cord-261028-sxux2ujo	262	28	)	)	-RRB-
cord-261028-sxux2ujo	262	29	.	.	.
cord-261028-sxux2ujo	263	1	In	in	IN
cord-261028-sxux2ujo	263	2	addition	addition	NN
cord-261028-sxux2ujo	263	3	to	to	IN
cord-261028-sxux2ujo	263	4	these	these	DT
cord-261028-sxux2ujo	263	5	effects	effect	NNS
cord-261028-sxux2ujo	263	6	on	on	IN
cord-261028-sxux2ujo	263	7	antigen	antigen	NN
cord-261028-sxux2ujo	263	8	persistence	persistence	NN
cord-261028-sxux2ujo	263	9	,	,	,
cord-261028-sxux2ujo	263	10	processing	processing	NN
cord-261028-sxux2ujo	263	11	and	and	CC
cord-261028-sxux2ujo	263	12	loading	loading	NN
cord-261028-sxux2ujo	263	13	,	,	,
cord-261028-sxux2ujo	263	14	type	type	NN
cord-261028-sxux2ujo	263	15	I	-PRON-	PRP
cord-261028-sxux2ujo	263	16	IFN	IFN	NNP
cord-261028-sxux2ujo	263	17	also	also	RB
cord-261028-sxux2ujo	263	18	increases	increase	VBZ
cord-261028-sxux2ujo	263	19	overall	overall	JJ
cord-261028-sxux2ujo	263	20	surface	surface	NN
cord-261028-sxux2ujo	263	21	expression	expression	NN
cord-261028-sxux2ujo	263	22	levels	level	NNS
cord-261028-sxux2ujo	263	23	of	of	IN
cord-261028-sxux2ujo	263	24	MHCI	MHCI	NNP
cord-261028-sxux2ujo	263	25	and	and	CC
cord-261028-sxux2ujo	263	26	MHCII	MHCII	NNP
cord-261028-sxux2ujo	263	27	,	,	,
cord-261028-sxux2ujo	263	28	as	as	RB
cord-261028-sxux2ujo	263	29	well	well	RB
cord-261028-sxux2ujo	263	30	as	as	IN
cord-261028-sxux2ujo	263	31	the	the	DT
cord-261028-sxux2ujo	263	32	membrane	membrane	NN
cord-261028-sxux2ujo	263	33	associated	associate	VBD
cord-261028-sxux2ujo	263	34	co	co	JJ
cord-261028-sxux2ujo	263	35	-	-	JJ
cord-261028-sxux2ujo	263	36	stimulatory	stimulatory	JJ
cord-261028-sxux2ujo	263	37	molecules	molecule	NNS
cord-261028-sxux2ujo	263	38	CD40	CD40	NNP
cord-261028-sxux2ujo	263	39	,	,	,
cord-261028-sxux2ujo	263	40	CD80	CD80	NNP
cord-261028-sxux2ujo	263	41	,	,	,
cord-261028-sxux2ujo	263	42	and	and	CC
cord-261028-sxux2ujo	263	43	CD86	CD86	NNP
cord-261028-sxux2ujo	263	44	.	.	.
cord-261028-sxux2ujo	264	1	Moreover	moreover	RB
cord-261028-sxux2ujo	264	2	,	,	,
cord-261028-sxux2ujo	264	3	type	type	NN
cord-261028-sxux2ujo	264	4	I	-PRON-	PRP
cord-261028-sxux2ujo	264	5	IFN	IFN	NNP
cord-261028-sxux2ujo	264	6	can	can	MD
cord-261028-sxux2ujo	264	7	serve	serve	VB
cord-261028-sxux2ujo	264	8	as	as	IN
cord-261028-sxux2ujo	264	9	a	a	DT
cord-261028-sxux2ujo	264	10	signal	signal	JJ
cord-261028-sxux2ujo	264	11	3	3	CD
cord-261028-sxux2ujo	264	12	cytokine	cytokine	NN
cord-261028-sxux2ujo	264	13	,	,	,
cord-261028-sxux2ujo	264	14	enhancing	enhance	VBG
cord-261028-sxux2ujo	264	15	CD8	CD8	NNP
cord-261028-sxux2ujo	264	16	+	+	CC
cord-261028-sxux2ujo	264	17	T	T	NNP
cord-261028-sxux2ujo	264	18	cell	cell	NN
cord-261028-sxux2ujo	264	19	priming	prime	VBG
cord-261028-sxux2ujo	264	20	through	through	IN
cord-261028-sxux2ujo	264	21	its	-PRON-	PRP$
cord-261028-sxux2ujo	264	22	signaling	signaling	NN
cord-261028-sxux2ujo	264	23	within	within	IN
cord-261028-sxux2ujo	264	24	T	t	NN
cord-261028-sxux2ujo	264	25	cells	cell	NNS
cord-261028-sxux2ujo	264	26	(	(	-LRB-
cord-261028-sxux2ujo	264	27	Agarwal	Agarwal	NNP
cord-261028-sxux2ujo	264	28	et	et	NNP
cord-261028-sxux2ujo	264	29	al	al	NNP
cord-261028-sxux2ujo	264	30	.	.	NNP
cord-261028-sxux2ujo	264	31	,	,	,
cord-261028-sxux2ujo	264	32	2009	2009	CD
cord-261028-sxux2ujo	264	33	;	;	:
cord-261028-sxux2ujo	264	34	Curtsinger	Curtsinger	NNP
cord-261028-sxux2ujo	264	35	and	and	CC
cord-261028-sxux2ujo	264	36	Mescher	Mescher	NNP
cord-261028-sxux2ujo	264	37	,	,	,
cord-261028-sxux2ujo	264	38	2010	2010	CD
cord-261028-sxux2ujo	264	39	;	;	:
cord-261028-sxux2ujo	264	40	Xiao	Xiao	NNP
cord-261028-sxux2ujo	264	41	et	et	NNP
cord-261028-sxux2ujo	264	42	al	al	NNP
cord-261028-sxux2ujo	264	43	.	.	NNP
cord-261028-sxux2ujo	264	44	,	,	,
cord-261028-sxux2ujo	264	45	2009	2009	CD
cord-261028-sxux2ujo	264	46	)	)	-RRB-
cord-261028-sxux2ujo	264	47	.	.	.
cord-261028-sxux2ujo	265	1	Table	table	NN
cord-261028-sxux2ujo	265	2	1	1	CD
cord-261028-sxux2ujo	265	3	)	)	-RRB-
cord-261028-sxux2ujo	265	4	.	.	.
cord-261028-sxux2ujo	266	1	In	in	IN
cord-261028-sxux2ujo	266	2	murine	murine	JJ
cord-261028-sxux2ujo	266	3	models	model	NNS
cord-261028-sxux2ujo	266	4	,	,	,
cord-261028-sxux2ujo	266	5	type	type	NN
cord-261028-sxux2ujo	266	6	I	-PRON-	PRP
cord-261028-sxux2ujo	266	7	IFN	IFN	NNP
cord-261028-sxux2ujo	266	8	seems	seem	VBZ
cord-261028-sxux2ujo	266	9	to	to	TO
cord-261028-sxux2ujo	266	10	be	be	VB
cord-261028-sxux2ujo	266	11	required	require	VBN
cord-261028-sxux2ujo	266	12	for	for	IN
cord-261028-sxux2ujo	266	13	anti	anti	JJ
cord-261028-sxux2ujo	266	14	-	-	JJ
cord-261028-sxux2ujo	266	15	tumor	tumor	JJ
cord-261028-sxux2ujo	266	16	immunity	immunity	NN
cord-261028-sxux2ujo	266	17	.	.	.
cord-261028-sxux2ujo	267	1	Dunn	Dunn	NNP
cord-261028-sxux2ujo	267	2	et	et	NNP
cord-261028-sxux2ujo	267	3	al	al	NNP
cord-261028-sxux2ujo	267	4	.	.	NNP
cord-261028-sxux2ujo	267	5	demonstrated	demonstrate	VBD
cord-261028-sxux2ujo	267	6	that	that	IN
cord-261028-sxux2ujo	267	7	mice	mouse	NNS
cord-261028-sxux2ujo	267	8	that	that	WDT
cord-261028-sxux2ujo	267	9	lacked	lack	VBD
cord-261028-sxux2ujo	267	10	IFNAR	IFNAR	NNP
cord-261028-sxux2ujo	267	11	were	be	VBD
cord-261028-sxux2ujo	267	12	more	more	RBR
cord-261028-sxux2ujo	267	13	susceptible	susceptible	JJ
cord-261028-sxux2ujo	267	14	to	to	IN
cord-261028-sxux2ujo	267	15	carcinogeninduced	carcinogeninduce	VBN
cord-261028-sxux2ujo	267	16	tumors	tumor	NNS
cord-261028-sxux2ujo	267	17	,	,	,
cord-261028-sxux2ujo	267	18	and	and	CC
cord-261028-sxux2ujo	267	19	mice	mouse	NNS
cord-261028-sxux2ujo	267	20	treated	treat	VBN
cord-261028-sxux2ujo	267	21	with	with	IN
cord-261028-sxux2ujo	267	22	anti	anti	JJ
cord-261028-sxux2ujo	267	23	-	-	JJ
cord-261028-sxux2ujo	267	24	IFNAR	ifnar	JJ
cord-261028-sxux2ujo	267	25	antibodies	antibody	NNS
cord-261028-sxux2ujo	267	26	were	be	VBD
cord-261028-sxux2ujo	267	27	much	much	RB
cord-261028-sxux2ujo	267	28	more	more	RBR
cord-261028-sxux2ujo	267	29	susceptible	susceptible	JJ
cord-261028-sxux2ujo	267	30	to	to	IN
cord-261028-sxux2ujo	267	31	transplanted	transplanted	JJ
cord-261028-sxux2ujo	267	32	tumor	tumor	NN
cord-261028-sxux2ujo	267	33	outgrowth	outgrowth	NN
cord-261028-sxux2ujo	267	34	than	than	IN
cord-261028-sxux2ujo	267	35	mice	mouse	NNS
cord-261028-sxux2ujo	267	36	given	give	VBN
cord-261028-sxux2ujo	267	37	isotype	isotype	NN
cord-261028-sxux2ujo	267	38	controls	control	NNS
cord-261028-sxux2ujo	267	39	(	(	-LRB-
cord-261028-sxux2ujo	267	40	Dunn	Dunn	NNP
cord-261028-sxux2ujo	267	41	et	et	NNP
cord-261028-sxux2ujo	267	42	al	al	NNP
cord-261028-sxux2ujo	267	43	.	.	NNP
cord-261028-sxux2ujo	267	44	,	,	,
cord-261028-sxux2ujo	267	45	2005a	2005a	CD
cord-261028-sxux2ujo	267	46	;	;	:
cord-261028-sxux2ujo	268	1	Dunn	Dunn	NNP
cord-261028-sxux2ujo	268	2	et	et	NNP
cord-261028-sxux2ujo	268	3	al	al	NNP
cord-261028-sxux2ujo	268	4	.	.	NNP
cord-261028-sxux2ujo	268	5	,	,	,
cord-261028-sxux2ujo	268	6	2005b	2005b	CD
cord-261028-sxux2ujo	268	7	)	)	-RRB-
cord-261028-sxux2ujo	268	8	.	.	.
cord-261028-sxux2ujo	269	1	Fuertes	Fuertes	NNP
cord-261028-sxux2ujo	269	2	et	et	NNP
cord-261028-sxux2ujo	269	3	al	al	NNP
cord-261028-sxux2ujo	269	4	.	.	NNP
cord-261028-sxux2ujo	269	5	discovered	discover	VBD
cord-261028-sxux2ujo	269	6	spontaneous	spontaneous	JJ
cord-261028-sxux2ujo	269	7	antitumor	antitumor	NN
cord-261028-sxux2ujo	269	8	CD8	CD8	NNP
cord-261028-sxux2ujo	269	9	+	+	CC
cord-261028-sxux2ujo	269	10	T	T	NNP
cord-261028-sxux2ujo	269	11	cell	cell	NN
cord-261028-sxux2ujo	269	12	responses	response	NNS
cord-261028-sxux2ujo	269	13	were	be	VBD
cord-261028-sxux2ujo	269	14	defective	defective	JJ
cord-261028-sxux2ujo	269	15	in	in	IN
cord-261028-sxux2ujo	269	16	mice	mouse	NNS
cord-261028-sxux2ujo	269	17	lacking	lack	VBG
cord-261028-sxux2ujo	269	18	either	either	CC
cord-261028-sxux2ujo	269	19	IFNAR	IFNAR	NNP
cord-261028-sxux2ujo	269	20	or	or	CC
cord-261028-sxux2ujo	269	21	STAT1	stat1	XX
cord-261028-sxux2ujo	269	22	,	,	,
cord-261028-sxux2ujo	269	23	a	a	DT
cord-261028-sxux2ujo	269	24	transcription	transcription	NN
cord-261028-sxux2ujo	269	25	factor	factor	NN
cord-261028-sxux2ujo	269	26	immediately	immediately	RB
cord-261028-sxux2ujo	269	27	downstream	downstream	RB
cord-261028-sxux2ujo	269	28	of	of	IN
cord-261028-sxux2ujo	269	29	IFN	IFN	NNP
cord-261028-sxux2ujo	269	30	signaling	signal	VBG
cord-261028-sxux2ujo	270	1	(	(	-LRB-
cord-261028-sxux2ujo	270	2	Fuertes	Fuertes	NNP
cord-261028-sxux2ujo	270	3	et	et	NNP
cord-261028-sxux2ujo	270	4	al	al	NNP
cord-261028-sxux2ujo	270	5	.	.	NNP
cord-261028-sxux2ujo	270	6	,	,	,
cord-261028-sxux2ujo	270	7	2011	2011	CD
cord-261028-sxux2ujo	270	8	)	)	-RRB-
cord-261028-sxux2ujo	270	9	.	.	.
cord-261028-sxux2ujo	271	1	Studies	study	NNS
cord-261028-sxux2ujo	271	2	of	of	IN
cord-261028-sxux2ujo	271	3	mice	mouse	NNS
cord-261028-sxux2ujo	271	4	lacking	lack	VBG
cord-261028-sxux2ujo	271	5	IFNAR	IFNAR	NNP
cord-261028-sxux2ujo	271	6	specifically	specifically	RB
cord-261028-sxux2ujo	271	7	on	on	IN
cord-261028-sxux2ujo	271	8	DCs	DCs	NNP
cord-261028-sxux2ujo	271	9	or	or	CC
cord-261028-sxux2ujo	271	10	lacking	lack	VBG
cord-261028-sxux2ujo	271	11	Batf3-dependent	Batf3-dependent	NNP
cord-261028-sxux2ujo	271	12	DC	DC	NNP
cord-261028-sxux2ujo	271	13	populations	population	NNS
cord-261028-sxux2ujo	271	14	demonstrated	demonstrate	VBD
cord-261028-sxux2ujo	271	15	that	that	IN
cord-261028-sxux2ujo	271	16	the	the	DT
cord-261028-sxux2ujo	271	17	antitumor	antitumor	NN
cord-261028-sxux2ujo	271	18	responses	response	NNS
cord-261028-sxux2ujo	271	19	were	be	VBD
cord-261028-sxux2ujo	271	20	dependent	dependent	JJ
cord-261028-sxux2ujo	271	21	on	on	IN
cord-261028-sxux2ujo	271	22	cDC1-like	cdc1-like	CD
cord-261028-sxux2ujo	271	23	DCs	dc	NNS
cord-261028-sxux2ujo	271	24	(	(	-LRB-
cord-261028-sxux2ujo	271	25	Diamond	Diamond	NNP
cord-261028-sxux2ujo	271	26	et	et	NNP
cord-261028-sxux2ujo	271	27	al	al	NNP
cord-261028-sxux2ujo	271	28	.	.	NNP
cord-261028-sxux2ujo	271	29	,	,	,
cord-261028-sxux2ujo	271	30	2011	2011	CD
cord-261028-sxux2ujo	271	31	;	;	:
cord-261028-sxux2ujo	271	32	Hildner	Hildner	NNP
cord-261028-sxux2ujo	271	33	et	et	NNP
cord-261028-sxux2ujo	271	34	al	al	NNP
cord-261028-sxux2ujo	271	35	.	.	NNP
cord-261028-sxux2ujo	271	36	,	,	,
cord-261028-sxux2ujo	271	37	2008	2008	CD
cord-261028-sxux2ujo	271	38	;	;	:
cord-261028-sxux2ujo	271	39	Klarquist	Klarquist	NNP
cord-261028-sxux2ujo	271	40	et	et	FW
cord-261028-sxux2ujo	271	41	al	al	NNP
cord-261028-sxux2ujo	271	42	.	.	.
cord-261028-sxux2ujo	272	1	,	,	,
cord-261028-sxux2ujo	272	2	2014	2014	CD
cord-261028-sxux2ujo	272	3	)	)	-RRB-
cord-261028-sxux2ujo	272	4	.	.	.
cord-261028-sxux2ujo	273	1	is	be	VBZ
cord-261028-sxux2ujo	273	2	not	not	RB
cord-261028-sxux2ujo	273	3	possible	possible	JJ
cord-261028-sxux2ujo	273	4	to	to	TO
cord-261028-sxux2ujo	273	5	be	be	VB
cord-261028-sxux2ujo	273	6	certain	certain	JJ
cord-261028-sxux2ujo	273	7	of	of	IN
cord-261028-sxux2ujo	273	8	the	the	DT
cord-261028-sxux2ujo	273	9	role	role	NN
cord-261028-sxux2ujo	273	10	of	of	IN
cord-261028-sxux2ujo	273	11	type	type	NN
cord-261028-sxux2ujo	274	1	I	-PRON-	PRP
cord-261028-sxux2ujo	274	2	IFN	IFN	NNP
cord-261028-sxux2ujo	274	3	in	in	IN
cord-261028-sxux2ujo	274	4	the	the	DT
cord-261028-sxux2ujo	274	5	immune	immune	JJ
cord-261028-sxux2ujo	274	6	response	response	NN
cord-261028-sxux2ujo	274	7	to	to	IN
cord-261028-sxux2ujo	274	8	human	human	JJ
cord-261028-sxux2ujo	274	9	cancers	cancer	NNS
cord-261028-sxux2ujo	274	10	,	,	,
cord-261028-sxux2ujo	274	11	but	but	CC
cord-261028-sxux2ujo	275	1	there	there	EX
cord-261028-sxux2ujo	275	2	is	be	VBZ
cord-261028-sxux2ujo	275	3	strong	strong	JJ
cord-261028-sxux2ujo	275	4	correlative	correlative	JJ
cord-261028-sxux2ujo	275	5	data	datum	NNS
cord-261028-sxux2ujo	275	6	suggesting	suggest	VBG
cord-261028-sxux2ujo	275	7	its	-PRON-	PRP$
cord-261028-sxux2ujo	275	8	importance	importance	NN
cord-261028-sxux2ujo	275	9	.	.	.
cord-261028-sxux2ujo	276	1	In	in	IN
cord-261028-sxux2ujo	276	2	human	human	JJ
cord-261028-sxux2ujo	276	3	patients	patient	NNS
cord-261028-sxux2ujo	276	4	with	with	IN
cord-261028-sxux2ujo	276	5	metastatic	metastatic	JJ
cord-261028-sxux2ujo	276	6	melanoma	melanoma	NN
cord-261028-sxux2ujo	276	7	,	,	,
cord-261028-sxux2ujo	276	8	metastatic	metastatic	JJ
cord-261028-sxux2ujo	276	9	lesions	lesion	NNS
cord-261028-sxux2ujo	276	10	infiltrated	infiltrate	VBN
cord-261028-sxux2ujo	276	11	with	with	IN
cord-261028-sxux2ujo	276	12	T	T	NNP
cord-261028-sxux2ujo	276	13	cells	cell	NNS
cord-261028-sxux2ujo	276	14	are	be	VBP
cord-261028-sxux2ujo	276	15	characterized	characterize	VBN
cord-261028-sxux2ujo	276	16	by	by	IN
cord-261028-sxux2ujo	276	17	an	an	DT
cord-261028-sxux2ujo	276	18	IFN	IFN	NNP
cord-261028-sxux2ujo	276	19	gene	gene	NN
cord-261028-sxux2ujo	276	20	signature	signature	NN
cord-261028-sxux2ujo	276	21	(	(	-LRB-
cord-261028-sxux2ujo	276	22	Fuertes	Fuertes	NNP
cord-261028-sxux2ujo	276	23	et	et	NNP
cord-261028-sxux2ujo	276	24	al	al	NNP
cord-261028-sxux2ujo	276	25	.	.	NNP
cord-261028-sxux2ujo	276	26	,	,	,
cord-261028-sxux2ujo	276	27	2011	2011	CD
cord-261028-sxux2ujo	276	28	;	;	:
cord-261028-sxux2ujo	276	29	Harlin	Harlin	NNP
cord-261028-sxux2ujo	276	30	et	et	NNP
cord-261028-sxux2ujo	276	31	al	al	NNP
cord-261028-sxux2ujo	276	32	.	.	NNP
cord-261028-sxux2ujo	276	33	,	,	,
cord-261028-sxux2ujo	276	34	2009	2009	CD
cord-261028-sxux2ujo	276	35	)	)	-RRB-
cord-261028-sxux2ujo	276	36	.	.	.
cord-261028-sxux2ujo	277	1	This	this	DT
cord-261028-sxux2ujo	277	2	inflamed	inflamed	JJ
cord-261028-sxux2ujo	277	3	phenotype	phenotype	NN
cord-261028-sxux2ujo	277	4	is	be	VBZ
cord-261028-sxux2ujo	277	5	associated	associate	VBN
cord-261028-sxux2ujo	277	6	both	both	CC
cord-261028-sxux2ujo	277	7	with	with	IN
cord-261028-sxux2ujo	277	8	inhibitory	inhibitory	JJ
cord-261028-sxux2ujo	277	9	factors	factor	NNS
cord-261028-sxux2ujo	277	10	that	that	WDT
cord-261028-sxux2ujo	277	11	suppress	suppress	VBP
cord-261028-sxux2ujo	277	12	T	t	NN
cord-261028-sxux2ujo	277	13	cell	cell	NN
cord-261028-sxux2ujo	277	14	function	function	NN
cord-261028-sxux2ujo	277	15	and	and	CC
cord-261028-sxux2ujo	277	16	with	with	IN
cord-261028-sxux2ujo	277	17	response	response	NN
cord-261028-sxux2ujo	277	18	to	to	IN
cord-261028-sxux2ujo	277	19	immunotherapy	immunotherapy	NN
cord-261028-sxux2ujo	277	20	,	,	,
cord-261028-sxux2ujo	277	21	including	include	VBG
cord-261028-sxux2ujo	277	22	checkpoint	checkpoint	NN
cord-261028-sxux2ujo	277	23	inhibitors	inhibitor	NNS
cord-261028-sxux2ujo	277	24	targeting	target	VBG
cord-261028-sxux2ujo	277	25	CTLA-4	CTLA-4	NNS
cord-261028-sxux2ujo	277	26	and	and	CC
cord-261028-sxux2ujo	277	27	PD-1	PD-1	NNP
cord-261028-sxux2ujo	277	28	(	(	-LRB-
cord-261028-sxux2ujo	277	29	Ji	Ji	NNP
cord-261028-sxux2ujo	277	30	et	et	FW
cord-261028-sxux2ujo	277	31	al	al	NNP
cord-261028-sxux2ujo	277	32	.	.	NNP
cord-261028-sxux2ujo	277	33	,	,	,
cord-261028-sxux2ujo	277	34	2012	2012	CD
cord-261028-sxux2ujo	277	35	;	;	:
cord-261028-sxux2ujo	277	36	Topalian	Topalian	NNP
cord-261028-sxux2ujo	277	37	et	et	NNP
cord-261028-sxux2ujo	277	38	al	al	NNP
cord-261028-sxux2ujo	277	39	.	.	NNP
cord-261028-sxux2ujo	277	40	,	,	,
cord-261028-sxux2ujo	277	41	2012	2012	CD
cord-261028-sxux2ujo	277	42	)	)	-RRB-
cord-261028-sxux2ujo	277	43	.	.	.
cord-261028-sxux2ujo	278	1	A	a	DT
cord-261028-sxux2ujo	278	2	type	type	NN
cord-261028-sxux2ujo	279	1	I	-PRON-	PRP
cord-261028-sxux2ujo	279	2	IFN	IFN	NNP
cord-261028-sxux2ujo	279	3	gene	gene	NN
cord-261028-sxux2ujo	279	4	signature	signature	NN
cord-261028-sxux2ujo	279	5	in	in	IN
cord-261028-sxux2ujo	279	6	the	the	DT
cord-261028-sxux2ujo	279	7	primary	primary	JJ
cord-261028-sxux2ujo	279	8	tumor	tumor	NN
cord-261028-sxux2ujo	279	9	at	at	IN
cord-261028-sxux2ujo	279	10	diagnosis	diagnosis	NN
cord-261028-sxux2ujo	279	11	has	have	VBZ
cord-261028-sxux2ujo	279	12	also	also	RB
cord-261028-sxux2ujo	279	13	been	be	VBN
cord-261028-sxux2ujo	279	14	found	find	VBN
cord-261028-sxux2ujo	279	15	to	to	TO
cord-261028-sxux2ujo	279	16	be	be	VB
cord-261028-sxux2ujo	279	17	associated	associate	VBN
cord-261028-sxux2ujo	279	18	with	with	IN
cord-261028-sxux2ujo	279	19	improved	improved	JJ
cord-261028-sxux2ujo	279	20	prognosis	prognosis	NN
cord-261028-sxux2ujo	279	21	and	and	CC
cord-261028-sxux2ujo	279	22	response	response	NN
cord-261028-sxux2ujo	279	23	to	to	IN
cord-261028-sxux2ujo	279	24	anthracycline	anthracycline	JJ
cord-261028-sxux2ujo	279	25	chemotherapy	chemotherapy	NN
cord-261028-sxux2ujo	279	26	in	in	IN
cord-261028-sxux2ujo	279	27	women	woman	NNS
cord-261028-sxux2ujo	279	28	with	with	IN
cord-261028-sxux2ujo	279	29	breast	breast	NN
cord-261028-sxux2ujo	279	30	cancer	cancer	NN
cord-261028-sxux2ujo	279	31	(	(	-LRB-
cord-261028-sxux2ujo	279	32	Sistigu	Sistigu	NNP
cord-261028-sxux2ujo	279	33	et	et	NNP
cord-261028-sxux2ujo	279	34	al	al	NNP
cord-261028-sxux2ujo	279	35	.	.	NNP
cord-261028-sxux2ujo	279	36	,	,	,
cord-261028-sxux2ujo	279	37	2014	2014	CD
cord-261028-sxux2ujo	279	38	)	)	-RRB-
cord-261028-sxux2ujo	279	39	.	.	.
cord-261028-sxux2ujo	280	1	These	these	DT
cord-261028-sxux2ujo	280	2	associations	association	NNS
cord-261028-sxux2ujo	280	3	are	be	VBP
cord-261028-sxux2ujo	280	4	supported	support	VBN
cord-261028-sxux2ujo	280	5	by	by	IN
cord-261028-sxux2ujo	280	6	studies	study	NNS
cord-261028-sxux2ujo	280	7	in	in	IN
cord-261028-sxux2ujo	280	8	murine	murine	JJ
cord-261028-sxux2ujo	280	9	models	model	NNS
cord-261028-sxux2ujo	280	10	,	,	,
cord-261028-sxux2ujo	280	11	demonstrating	demonstrate	VBG
cord-261028-sxux2ujo	280	12	that	that	IN
cord-261028-sxux2ujo	280	13	breast	breast	NN
cord-261028-sxux2ujo	280	14	cancer	cancer	NN
cord-261028-sxux2ujo	280	15	is	be	VBZ
cord-261028-sxux2ujo	280	16	more	more	RBR
cord-261028-sxux2ujo	280	17	likely	likely	JJ
cord-261028-sxux2ujo	280	18	to	to	TO
cord-261028-sxux2ujo	280	19	metastasize	metastasize	VB
cord-261028-sxux2ujo	280	20	to	to	IN
cord-261028-sxux2ujo	280	21	bone	bone	NN
cord-261028-sxux2ujo	280	22	when	when	WRB
cord-261028-sxux2ujo	280	23	the	the	DT
cord-261028-sxux2ujo	280	24	IRF7	IRF7	NNP
cord-261028-sxux2ujo	280	25	pathway	pathway	NN
cord-261028-sxux2ujo	280	26	is	be	VBZ
cord-261028-sxux2ujo	280	27	blocked	block	VBN
cord-261028-sxux2ujo	281	1	(	(	-LRB-
cord-261028-sxux2ujo	281	2	Bidwell	Bidwell	NNP
cord-261028-sxux2ujo	281	3	et	et	NNP
cord-261028-sxux2ujo	281	4	al	al	NNP
cord-261028-sxux2ujo	281	5	.	.	NNP
cord-261028-sxux2ujo	281	6	,	,	,
cord-261028-sxux2ujo	281	7	2012	2012	CD
cord-261028-sxux2ujo	281	8	)	)	-RRB-
cord-261028-sxux2ujo	281	9	.	.	.
cord-261028-sxux2ujo	282	1	This	this	DT
cord-261028-sxux2ujo	282	2	pattern	pattern	NN
cord-261028-sxux2ujo	282	3	also	also	RB
cord-261028-sxux2ujo	282	4	holds	hold	VBZ
cord-261028-sxux2ujo	282	5	in	in	IN
cord-261028-sxux2ujo	282	6	studies	study	NNS
cord-261028-sxux2ujo	282	7	of	of	IN
cord-261028-sxux2ujo	282	8	cancer	cancer	NN
cord-261028-sxux2ujo	282	9	vaccines	vaccine	NNS
cord-261028-sxux2ujo	282	10	,	,	,
cord-261028-sxux2ujo	282	11	where	where	WRB
cord-261028-sxux2ujo	282	12	a	a	DT
cord-261028-sxux2ujo	282	13	similar	similar	JJ
cord-261028-sxux2ujo	282	14	gene	gene	NN
cord-261028-sxux2ujo	282	15	signature	signature	NN
cord-261028-sxux2ujo	282	16	has	have	VBZ
cord-261028-sxux2ujo	282	17	been	be	VBN
cord-261028-sxux2ujo	282	18	found	find	VBN
cord-261028-sxux2ujo	282	19	to	to	TO
cord-261028-sxux2ujo	282	20	correlate	correlate	VB
cord-261028-sxux2ujo	282	21	with	with	IN
cord-261028-sxux2ujo	282	22	improved	improve	VBN
cord-261028-sxux2ujo	282	23	clinical	clinical	JJ
cord-261028-sxux2ujo	282	24	responses	response	NNS
cord-261028-sxux2ujo	282	25	.	.	.
cord-261028-sxux2ujo	283	1	In	in	IN
cord-261028-sxux2ujo	283	2	aggregate	aggregate	NN
cord-261028-sxux2ujo	283	3	,	,	,
cord-261028-sxux2ujo	283	4	these	these	DT
cord-261028-sxux2ujo	283	5	findings	finding	NNS
cord-261028-sxux2ujo	283	6	support	support	VBP
cord-261028-sxux2ujo	283	7	the	the	DT
cord-261028-sxux2ujo	283	8	relevance	relevance	NN
cord-261028-sxux2ujo	283	9	of	of	IN
cord-261028-sxux2ujo	283	10	type	type	NN
cord-261028-sxux2ujo	283	11	I	-PRON-	PRP
cord-261028-sxux2ujo	283	12	IFN	IFN	NNP
cord-261028-sxux2ujo	283	13	responses	response	NNS
cord-261028-sxux2ujo	283	14	in	in	IN
cord-261028-sxux2ujo	283	15	human	human	JJ
cord-261028-sxux2ujo	283	16	patients	patient	NNS
cord-261028-sxux2ujo	283	17	,	,	,
cord-261028-sxux2ujo	283	18	and	and	CC
cord-261028-sxux2ujo	283	19	in	in	IN
cord-261028-sxux2ujo	283	20	fact	fact	NN
cord-261028-sxux2ujo	283	21	motivated	motivate	VBN
cord-261028-sxux2ujo	283	22	much	much	JJ
cord-261028-sxux2ujo	283	23	of	of	IN
cord-261028-sxux2ujo	283	24	the	the	DT
cord-261028-sxux2ujo	283	25	work	work	NN
cord-261028-sxux2ujo	283	26	highlighting	highlight	VBG
cord-261028-sxux2ujo	283	27	the	the	DT
cord-261028-sxux2ujo	283	28	importance	importance	NN
cord-261028-sxux2ujo	283	29	of	of	IN
cord-261028-sxux2ujo	283	30	IFN	IFN	NNP
cord-261028-sxux2ujo	283	31	in	in	IN
cord-261028-sxux2ujo	283	32	the	the	DT
cord-261028-sxux2ujo	283	33	animal	animal	NN
cord-261028-sxux2ujo	283	34	models	model	NNS
cord-261028-sxux2ujo	283	35	(	(	-LRB-
cord-261028-sxux2ujo	283	36	Ulloa	Ulloa	NNP
cord-261028-sxux2ujo	283	37	-	-	HYPH
cord-261028-sxux2ujo	283	38	Montoya	Montoya	NNP
cord-261028-sxux2ujo	283	39	et	et	NNP
cord-261028-sxux2ujo	283	40	al	al	NNP
cord-261028-sxux2ujo	283	41	.	.	.
cord-261028-sxux2ujo	284	1	,	,	,
cord-261028-sxux2ujo	284	2	2013	2013	CD
cord-261028-sxux2ujo	284	3	)	)	-RRB-
cord-261028-sxux2ujo	284	4	.	.	.
cord-261028-sxux2ujo	285	1	Signaling	signal	VBG
cord-261028-sxux2ujo	285	2	through	through	IN
cord-261028-sxux2ujo	285	3	the	the	DT
cord-261028-sxux2ujo	285	4	STING	sting	NN
cord-261028-sxux2ujo	285	5	pathway	pathway	NN
cord-261028-sxux2ujo	285	6	is	be	VBZ
cord-261028-sxux2ujo	285	7	an	an	DT
cord-261028-sxux2ujo	285	8	essential	essential	JJ
cord-261028-sxux2ujo	285	9	precursor	precursor	NN
cord-261028-sxux2ujo	285	10	to	to	IN
cord-261028-sxux2ujo	285	11	generating	generate	VBG
cord-261028-sxux2ujo	285	12	the	the	DT
cord-261028-sxux2ujo	285	13	type	type	NN
cord-261028-sxux2ujo	285	14	I	-PRON-	PRP
cord-261028-sxux2ujo	285	15	IFN	IFN	NNP
cord-261028-sxux2ujo	285	16	needed	need	VBD
cord-261028-sxux2ujo	285	17	for	for	IN
cord-261028-sxux2ujo	285	18	both	both	CC
cord-261028-sxux2ujo	285	19	spontaneous	spontaneous	JJ
cord-261028-sxux2ujo	285	20	and	and	CC
cord-261028-sxux2ujo	285	21	treatment	treatment	NN
cord-261028-sxux2ujo	285	22	induced	induce	VBN
cord-261028-sxux2ujo	285	23	cancer	cancer	NN
cord-261028-sxux2ujo	285	24	immune	immune	JJ
cord-261028-sxux2ujo	285	25	responses	response	NNS
cord-261028-sxux2ujo	285	26	.	.	.
cord-261028-sxux2ujo	286	1	DNA	dna	NN
cord-261028-sxux2ujo	286	2	sensing	sensing	NN
cord-261028-sxux2ujo	286	3	by	by	IN
cord-261028-sxux2ujo	286	4	STING	sting	NN
cord-261028-sxux2ujo	286	5	is	be	VBZ
cord-261028-sxux2ujo	286	6	the	the	DT
cord-261028-sxux2ujo	286	7	upstream	upstream	JJ
cord-261028-sxux2ujo	286	8	link	link	NN
cord-261028-sxux2ujo	286	9	that	that	WDT
cord-261028-sxux2ujo	286	10	triggers	trigger	VBZ
cord-261028-sxux2ujo	286	11	type	type	NN
cord-261028-sxux2ujo	287	1	I	-PRON-	PRP
cord-261028-sxux2ujo	287	2	IFN	IFN	NNP
cord-261028-sxux2ujo	287	3	production	production	NN
cord-261028-sxux2ujo	287	4	by	by	IN
cord-261028-sxux2ujo	287	5	DCs	DCs	NNP
cord-261028-sxux2ujo	287	6	and	and	CC
cord-261028-sxux2ujo	287	7	facilitates	facilitate	VBZ
cord-261028-sxux2ujo	287	8	effective	effective	JJ
cord-261028-sxux2ujo	287	9	cross	cross	NN
cord-261028-sxux2ujo	287	10	-	-	JJ
cord-261028-sxux2ujo	287	11	priming	priming	NN
cord-261028-sxux2ujo	287	12	of	of	IN
cord-261028-sxux2ujo	287	13	tumor	tumor	NN
cord-261028-sxux2ujo	287	14	specific	specific	JJ
cord-261028-sxux2ujo	287	15	CD8	CD8	NNP
cord-261028-sxux2ujo	287	16	+	+	CC
cord-261028-sxux2ujo	287	17	T	t	NN
cord-261028-sxux2ujo	287	18	cells	cell	NNS
cord-261028-sxux2ujo	287	19	.	.	.
cord-261028-sxux2ujo	288	1	This	this	DT
cord-261028-sxux2ujo	288	2	DNA	dna	NN
cord-261028-sxux2ujo	288	3	is	be	VBZ
cord-261028-sxux2ujo	288	4	likely	likely	RB
cord-261028-sxux2ujo	288	5	derived	derive	VBN
cord-261028-sxux2ujo	288	6	from	from	IN
cord-261028-sxux2ujo	288	7	stressed	stressed	JJ
cord-261028-sxux2ujo	288	8	and	and	CC
cord-261028-sxux2ujo	288	9	dying	die	VBG
cord-261028-sxux2ujo	288	10	cancer	cancer	NN
cord-261028-sxux2ujo	288	11	cells	cell	NNS
cord-261028-sxux2ujo	288	12	,	,	,
cord-261028-sxux2ujo	288	13	and	and	CC
cord-261028-sxux2ujo	288	14	is	be	VBZ
cord-261028-sxux2ujo	288	15	introduced	introduce	VBN
cord-261028-sxux2ujo	288	16	into	into	IN
cord-261028-sxux2ujo	288	17	the	the	DT
cord-261028-sxux2ujo	288	18	DC	DC	NNP
cord-261028-sxux2ujo	288	19	cytosol	cytosol	NN
cord-261028-sxux2ujo	288	20	through	through	IN
cord-261028-sxux2ujo	288	21	a	a	DT
cord-261028-sxux2ujo	288	22	yet	yet	RB
cord-261028-sxux2ujo	288	23	unknown	unknown	JJ
cord-261028-sxux2ujo	288	24	mechanism	mechanism	NN
cord-261028-sxux2ujo	288	25	where	where	WRB
cord-261028-sxux2ujo	288	26	it	-PRON-	PRP
cord-261028-sxux2ujo	288	27	binds	bind	VBZ
cord-261028-sxux2ujo	288	28	to	to	IN
cord-261028-sxux2ujo	288	29	cGAS	cgas	NN
cord-261028-sxux2ujo	288	30	,	,	,
cord-261028-sxux2ujo	288	31	which	which	WDT
cord-261028-sxux2ujo	288	32	initiates	initiate	VBZ
cord-261028-sxux2ujo	288	33	STING	sting	NN
cord-261028-sxux2ujo	288	34	mediated	mediate	VBN
cord-261028-sxux2ujo	288	35	type	type	NN
cord-261028-sxux2ujo	289	1	I	-PRON-	PRP
cord-261028-sxux2ujo	289	2	IFN	IFN	NNP
cord-261028-sxux2ujo	289	3	transcription	transcription	NN
cord-261028-sxux2ujo	290	1	(	(	-LRB-
cord-261028-sxux2ujo	290	2	Fig	Fig	NNP
cord-261028-sxux2ujo	290	3	.	.	NNP
cord-261028-sxux2ujo	290	4	2	2	CD
cord-261028-sxux2ujo	290	5	)	)	-RRB-
cord-261028-sxux2ujo	290	6	.	.	.
cord-261028-sxux2ujo	291	1	The	the	DT
cord-261028-sxux2ujo	291	2	importance	importance	NN
cord-261028-sxux2ujo	291	3	of	of	IN
cord-261028-sxux2ujo	291	4	this	this	DT
cord-261028-sxux2ujo	291	5	pathway	pathway	NN
cord-261028-sxux2ujo	291	6	has	have	VBZ
cord-261028-sxux2ujo	291	7	been	be	VBN
cord-261028-sxux2ujo	291	8	demonstrated	demonstrate	VBN
cord-261028-sxux2ujo	291	9	in	in	IN
cord-261028-sxux2ujo	291	10	a	a	DT
cord-261028-sxux2ujo	291	11	variety	variety	NN
cord-261028-sxux2ujo	291	12	of	of	IN
cord-261028-sxux2ujo	291	13	tumor	tumor	NN
cord-261028-sxux2ujo	291	14	models	model	NNS
cord-261028-sxux2ujo	291	15	,	,	,
cord-261028-sxux2ujo	291	16	including	include	VBG
cord-261028-sxux2ujo	291	17	colon	colon	NN
cord-261028-sxux2ujo	291	18	carcinoma	carcinoma	NN
cord-261028-sxux2ujo	291	19	,	,	,
cord-261028-sxux2ujo	291	20	melanoma	melanoma	NN
cord-261028-sxux2ujo	291	21	,	,	,
cord-261028-sxux2ujo	291	22	and	and	CC
cord-261028-sxux2ujo	291	23	lymphoma	lymphoma	NN
cord-261028-sxux2ujo	291	24	.	.	.
cord-261028-sxux2ujo	292	1	(	(	-LRB-
cord-261028-sxux2ujo	292	2	Woo	woo	UH
cord-261028-sxux2ujo	292	3	et	et	FW
cord-261028-sxux2ujo	292	4	al	al	NNP
cord-261028-sxux2ujo	292	5	.	.	NNP
cord-261028-sxux2ujo	292	6	,	,	,
cord-261028-sxux2ujo	292	7	2014	2014	CD
cord-261028-sxux2ujo	292	8	)	)	-RRB-
cord-261028-sxux2ujo	292	9	.	.	.
cord-261028-sxux2ujo	293	1	STING	STING	NNP
cord-261028-sxux2ujo	293	2	was	be	VBD
cord-261028-sxux2ujo	293	3	also	also	RB
cord-261028-sxux2ujo	293	4	required	require	VBN
cord-261028-sxux2ujo	293	5	for	for	IN
cord-261028-sxux2ujo	293	6	spontaneous	spontaneous	JJ
cord-261028-sxux2ujo	293	7	rejection	rejection	NN
cord-261028-sxux2ujo	293	8	of	of	IN
cord-261028-sxux2ujo	293	9	an	an	DT
cord-261028-sxux2ujo	293	10	immunogenic	immunogenic	JJ
cord-261028-sxux2ujo	293	11	sarcoma	sarcoma	NN
cord-261028-sxux2ujo	293	12	,	,	,
cord-261028-sxux2ujo	293	13	and	and	CC
cord-261028-sxux2ujo	293	14	the	the	DT
cord-261028-sxux2ujo	293	15	authors	author	NNS
cord-261028-sxux2ujo	293	16	nicely	nicely	RB
cord-261028-sxux2ujo	293	17	explore	explore	VBP
cord-261028-sxux2ujo	293	18	the	the	DT
cord-261028-sxux2ujo	293	19	mechanism	mechanism	NN
cord-261028-sxux2ujo	293	20	,	,	,
cord-261028-sxux2ujo	293	21	showing	show	VBG
cord-261028-sxux2ujo	293	22	that	that	IN
cord-261028-sxux2ujo	293	23	the	the	DT
cord-261028-sxux2ujo	293	24	STING	sting	NN
cord-261028-sxux2ujo	293	25	pathway	pathway	NN
cord-261028-sxux2ujo	293	26	is	be	VBZ
cord-261028-sxux2ujo	293	27	activated	activate	VBN
cord-261028-sxux2ujo	293	28	in	in	IN
cord-261028-sxux2ujo	293	29	host	host	NN
cord-261028-sxux2ujo	293	30	DCs	dc	NNS
cord-261028-sxux2ujo	293	31	as	as	IN
cord-261028-sxux2ujo	293	32	a	a	DT
cord-261028-sxux2ujo	293	33	result	result	NN
cord-261028-sxux2ujo	293	34	of	of	IN
cord-261028-sxux2ujo	293	35	sensing	sense	VBG
cord-261028-sxux2ujo	293	36	tumor	tumor	NN
cord-261028-sxux2ujo	293	37	derived	derive	VBN
cord-261028-sxux2ujo	293	38	DNA	dna	NN
cord-261028-sxux2ujo	293	39	(	(	-LRB-
cord-261028-sxux2ujo	293	40	Woo	woo	UH
cord-261028-sxux2ujo	293	41	et	et	FW
cord-261028-sxux2ujo	293	42	al	al	NNP
cord-261028-sxux2ujo	293	43	.	.	NNP
cord-261028-sxux2ujo	293	44	,	,	,
cord-261028-sxux2ujo	293	45	2014	2014	CD
cord-261028-sxux2ujo	293	46	;	;	:
cord-261028-sxux2ujo	293	47	Woo	Woo	NNP
cord-261028-sxux2ujo	293	48	et	et	NNP
cord-261028-sxux2ujo	293	49	al	al	NNP
cord-261028-sxux2ujo	293	50	.	.	NNP
cord-261028-sxux2ujo	293	51	,	,	,
cord-261028-sxux2ujo	293	52	2015	2015	CD
cord-261028-sxux2ujo	293	53	)	)	-RRB-
cord-261028-sxux2ujo	293	54	.	.	.
cord-261028-sxux2ujo	294	1	These	these	DT
cord-261028-sxux2ujo	294	2	findings	finding	NNS
cord-261028-sxux2ujo	294	3	have	have	VBP
cord-261028-sxux2ujo	294	4	been	be	VBN
cord-261028-sxux2ujo	294	5	extended	extend	VBN
cord-261028-sxux2ujo	294	6	to	to	IN
cord-261028-sxux2ujo	294	7	other	other	JJ
cord-261028-sxux2ujo	294	8	tumor	tumor	NN
cord-261028-sxux2ujo	294	9	models	model	NNS
cord-261028-sxux2ujo	294	10	,	,	,
cord-261028-sxux2ujo	294	11	such	such	JJ
cord-261028-sxux2ujo	294	12	as	as	IN
cord-261028-sxux2ujo	294	13	colitis	colitis	NN
cord-261028-sxux2ujo	294	14	induced	induce	VBN
cord-261028-sxux2ujo	294	15	cancer	cancer	NN
cord-261028-sxux2ujo	294	16	,	,	,
cord-261028-sxux2ujo	294	17	in	in	IN
cord-261028-sxux2ujo	294	18	which	which	WDT
cord-261028-sxux2ujo	294	19	STING	sting	VB
cord-261028-sxux2ujo	294	20	deficient	deficient	JJ
cord-261028-sxux2ujo	294	21	mice	mouse	NNS
cord-261028-sxux2ujo	294	22	have	have	VBP
cord-261028-sxux2ujo	294	23	increased	increase	VBN
cord-261028-sxux2ujo	294	24	susceptibility	susceptibility	NN
cord-261028-sxux2ujo	294	25	to	to	IN
cord-261028-sxux2ujo	294	26	colon	colon	NN
cord-261028-sxux2ujo	294	27	cancer	cancer	NN
cord-261028-sxux2ujo	294	28	oncogenesis	oncogenesis	NN
cord-261028-sxux2ujo	294	29	in	in	IN
cord-261028-sxux2ujo	294	30	response	response	NN
cord-261028-sxux2ujo	294	31	to	to	IN
cord-261028-sxux2ujo	294	32	inflammation	inflammation	NN
cord-261028-sxux2ujo	294	33	(	(	-LRB-
cord-261028-sxux2ujo	294	34	Zhu	zhu	FW
cord-261028-sxux2ujo	294	35	et	et	FW
cord-261028-sxux2ujo	294	36	al	al	NNP
cord-261028-sxux2ujo	294	37	.	.	NNP
cord-261028-sxux2ujo	294	38	,	,	,
cord-261028-sxux2ujo	294	39	2014	2014	CD
cord-261028-sxux2ujo	294	40	;	;	:
cord-261028-sxux2ujo	294	41	Ahn	Ahn	NNP
cord-261028-sxux2ujo	294	42	et	et	NNP
cord-261028-sxux2ujo	294	43	al	al	NNP
cord-261028-sxux2ujo	294	44	.	.	NNP
cord-261028-sxux2ujo	294	45	,	,	,
cord-261028-sxux2ujo	294	46	2015	2015	CD
cord-261028-sxux2ujo	294	47	)	)	-RRB-
cord-261028-sxux2ujo	294	48	.	.	.
cord-261028-sxux2ujo	295	1	In	in	IN
cord-261028-sxux2ujo	295	2	a	a	DT
cord-261028-sxux2ujo	295	3	mouse	mouse	NN
cord-261028-sxux2ujo	295	4	model	model	NN
cord-261028-sxux2ujo	295	5	that	that	WDT
cord-261028-sxux2ujo	295	6	spontaneously	spontaneously	RB
cord-261028-sxux2ujo	295	7	develops	develop	VBZ
cord-261028-sxux2ujo	295	8	intracranial	intracranial	JJ
cord-261028-sxux2ujo	295	9	glioma	glioma	NN
cord-261028-sxux2ujo	295	10	,	,	,
cord-261028-sxux2ujo	295	11	a	a	DT
cord-261028-sxux2ujo	295	12	loss	loss	NN
cord-261028-sxux2ujo	295	13	of	of	IN
cord-261028-sxux2ujo	295	14	function	function	NN
cord-261028-sxux2ujo	295	15	mutation	mutation	NN
cord-261028-sxux2ujo	295	16	in	in	IN
cord-261028-sxux2ujo	295	17	STING	sting	NN
cord-261028-sxux2ujo	295	18	results	result	NNS
cord-261028-sxux2ujo	295	19	in	in	IN
cord-261028-sxux2ujo	295	20	reduced	reduce	VBN
cord-261028-sxux2ujo	295	21	production	production	NN
cord-261028-sxux2ujo	295	22	of	of	IN
cord-261028-sxux2ujo	295	23	type	type	NN
cord-261028-sxux2ujo	296	1	I	-PRON-	PRP
cord-261028-sxux2ujo	296	2	IFN	IFN	NNP
cord-261028-sxux2ujo	296	3	by	by	IN
cord-261028-sxux2ujo	296	4	myeloid	myeloid	JJ
cord-261028-sxux2ujo	296	5	cells	cell	NNS
cord-261028-sxux2ujo	296	6	with	with	IN
cord-261028-sxux2ujo	296	7	impairment	impairment	NN
cord-261028-sxux2ujo	296	8	of	of	IN
cord-261028-sxux2ujo	296	9	tumor	tumor	NN
cord-261028-sxux2ujo	296	10	control	control	NN
cord-261028-sxux2ujo	296	11	by	by	IN
cord-261028-sxux2ujo	296	12	the	the	DT
cord-261028-sxux2ujo	296	13	immune	immune	JJ
cord-261028-sxux2ujo	296	14	system	system	NN
cord-261028-sxux2ujo	296	15	(	(	-LRB-
cord-261028-sxux2ujo	296	16	Ohkuri	Ohkuri	NNP
cord-261028-sxux2ujo	296	17	et	et	NNP
cord-261028-sxux2ujo	296	18	al	al	NNP
cord-261028-sxux2ujo	296	19	.	.	.
cord-261028-sxux2ujo	297	1	,	,	,
cord-261028-sxux2ujo	297	2	2014	2014	CD
cord-261028-sxux2ujo	297	3	)	)	-RRB-
cord-261028-sxux2ujo	297	4	.	.	.
cord-261028-sxux2ujo	298	1	DNA	dna	NN
cord-261028-sxux2ujo	298	2	damage	damage	NN
cord-261028-sxux2ujo	298	3	is	be	VBZ
cord-261028-sxux2ujo	298	4	the	the	DT
cord-261028-sxux2ujo	298	5	likely	likely	JJ
cord-261028-sxux2ujo	298	6	stimulus	stimulus	NN
cord-261028-sxux2ujo	298	7	for	for	IN
cord-261028-sxux2ujo	298	8	activating	activate	VBG
cord-261028-sxux2ujo	298	9	STING	sting	NN
cord-261028-sxux2ujo	298	10	and	and	CC
cord-261028-sxux2ujo	298	11	transcription	transcription	NN
cord-261028-sxux2ujo	298	12	of	of	IN
cord-261028-sxux2ujo	298	13	type	type	NN
cord-261028-sxux2ujo	298	14	I	-PRON-	PRP
cord-261028-sxux2ujo	298	15	IFN	IFN	NNP
cord-261028-sxux2ujo	298	16	,	,	,
cord-261028-sxux2ujo	298	17	as	as	IN
cord-261028-sxux2ujo	298	18	a	a	DT
cord-261028-sxux2ujo	298	19	breast	breast	NN
cord-261028-sxux2ujo	298	20	cancer	cancer	NN
cord-261028-sxux2ujo	298	21	model	model	NN
cord-261028-sxux2ujo	298	22	defective	defective	JJ
cord-261028-sxux2ujo	298	23	in	in	IN
cord-261028-sxux2ujo	298	24	DNA	dna	NN
cord-261028-sxux2ujo	298	25	damage	damage	NN
cord-261028-sxux2ujo	298	26	repair	repair	NN
cord-261028-sxux2ujo	298	27	is	be	VBZ
cord-261028-sxux2ujo	298	28	found	find	VBN
cord-261028-sxux2ujo	298	29	to	to	TO
cord-261028-sxux2ujo	298	30	have	have	VB
cord-261028-sxux2ujo	298	31	accumulation	accumulation	NN
cord-261028-sxux2ujo	298	32	of	of	IN
cord-261028-sxux2ujo	298	33	DNA	dna	NN
cord-261028-sxux2ujo	298	34	in	in	IN
cord-261028-sxux2ujo	298	35	the	the	DT
cord-261028-sxux2ujo	298	36	cytosol	cytosol	NN
cord-261028-sxux2ujo	298	37	and	and	CC
cord-261028-sxux2ujo	298	38	activation	activation	NN
cord-261028-sxux2ujo	298	39	of	of	IN
cord-261028-sxux2ujo	298	40	an	an	DT
cord-261028-sxux2ujo	298	41	IFN	IFN	NNP
cord-261028-sxux2ujo	298	42	response	response	NN
cord-261028-sxux2ujo	298	43	in	in	IN
cord-261028-sxux2ujo	298	44	a	a	DT
cord-261028-sxux2ujo	298	45	STING	sting	NN
cord-261028-sxux2ujo	298	46	dependent	dependent	JJ
cord-261028-sxux2ujo	298	47	manner	manner	NN
cord-261028-sxux2ujo	299	1	(	(	-LRB-
cord-261028-sxux2ujo	299	2	Parkes	Parkes	NNP
cord-261028-sxux2ujo	299	3	et	et	NNP
cord-261028-sxux2ujo	299	4	al	al	NNP
cord-261028-sxux2ujo	299	5	.	.	NNP
cord-261028-sxux2ujo	299	6	,	,	,
cord-261028-sxux2ujo	299	7	2017	2017	CD
cord-261028-sxux2ujo	299	8	)	)	-RRB-
cord-261028-sxux2ujo	299	9	.	.	.
cord-261028-sxux2ujo	300	1	These	these	DT
cord-261028-sxux2ujo	300	2	tumors	tumor	NNS
cord-261028-sxux2ujo	300	3	with	with	IN
cord-261028-sxux2ujo	300	4	impaired	impaired	JJ
cord-261028-sxux2ujo	300	5	DNA	dna	NN
cord-261028-sxux2ujo	300	6	damage	damage	NN
cord-261028-sxux2ujo	300	7	repair	repair	NN
cord-261028-sxux2ujo	300	8	are	be	VBP
cord-261028-sxux2ujo	300	9	grown	grow	VBN
cord-261028-sxux2ujo	300	10	in	in	IN
cord-261028-sxux2ujo	300	11	mice	mouse	NNS
cord-261028-sxux2ujo	300	12	,	,	,
cord-261028-sxux2ujo	300	13	they	-PRON-	PRP
cord-261028-sxux2ujo	300	14	develop	develop	VBP
cord-261028-sxux2ujo	300	15	a	a	DT
cord-261028-sxux2ujo	300	16	T	t	NN
cord-261028-sxux2ujo	300	17	cell	cell	NN
cord-261028-sxux2ujo	300	18	infiltrate	infiltrate	NN
cord-261028-sxux2ujo	300	19	compared	compare	VBN
cord-261028-sxux2ujo	300	20	with	with	IN
cord-261028-sxux2ujo	300	21	the	the	DT
cord-261028-sxux2ujo	300	22	wild	wild	JJ
cord-261028-sxux2ujo	300	23	type	type	NN
cord-261028-sxux2ujo	300	24	breast	breast	NN
cord-261028-sxux2ujo	300	25	cancer	cancer	NN
cord-261028-sxux2ujo	300	26	tumors	tumor	NNS
cord-261028-sxux2ujo	300	27	.	.	.
cord-261028-sxux2ujo	301	1	approaches	approach	NNS
cord-261028-sxux2ujo	301	2	have	have	VBP
cord-261028-sxux2ujo	301	3	now	now	RB
cord-261028-sxux2ujo	301	4	been	be	VBN
cord-261028-sxux2ujo	301	5	shown	show	VBN
cord-261028-sxux2ujo	301	6	to	to	TO
cord-261028-sxux2ujo	301	7	require	require	VB
cord-261028-sxux2ujo	301	8	the	the	DT
cord-261028-sxux2ujo	301	9	DC	DC	NNP
cord-261028-sxux2ujo	301	10	-	-	HYPH
cord-261028-sxux2ujo	301	11	STING	STING	NNP
cord-261028-sxux2ujo	301	12	-	-	HYPH
cord-261028-sxux2ujo	301	13	IFN	IFN	NNP
cord-261028-sxux2ujo	301	14	pathway	pathway	NN
cord-261028-sxux2ujo	301	15	for	for	IN
cord-261028-sxux2ujo	301	16	their	-PRON-	PRP$
cord-261028-sxux2ujo	301	17	effects	effect	NNS
cord-261028-sxux2ujo	301	18	.	.	.
cord-261028-sxux2ujo	302	1	Radiation	radiation	NN
cord-261028-sxux2ujo	302	2	therapy	therapy	NN
cord-261028-sxux2ujo	302	3	is	be	VBZ
cord-261028-sxux2ujo	302	4	a	a	DT
cord-261028-sxux2ujo	302	5	prime	prime	JJ
cord-261028-sxux2ujo	302	6	example	example	NN
cord-261028-sxux2ujo	302	7	of	of	IN
cord-261028-sxux2ujo	302	8	this	this	DT
cord-261028-sxux2ujo	302	9	.	.	.
cord-261028-sxux2ujo	303	1	Ionizing	ionize	VBG
cord-261028-sxux2ujo	303	2	radiation	radiation	NN
cord-261028-sxux2ujo	303	3	has	have	VBZ
cord-261028-sxux2ujo	303	4	long	long	RB
cord-261028-sxux2ujo	303	5	been	be	VBN
cord-261028-sxux2ujo	303	6	known	know	VBN
cord-261028-sxux2ujo	303	7	to	to	TO
cord-261028-sxux2ujo	303	8	selectively	selectively	RB
cord-261028-sxux2ujo	303	9	kill	kill	VB
cord-261028-sxux2ujo	303	10	cancer	cancer	NN
cord-261028-sxux2ujo	303	11	cells	cell	NNS
cord-261028-sxux2ujo	303	12	and	and	CC
cord-261028-sxux2ujo	303	13	has	have	VBZ
cord-261028-sxux2ujo	303	14	been	be	VBN
cord-261028-sxux2ujo	303	15	used	use	VBN
cord-261028-sxux2ujo	303	16	in	in	IN
cord-261028-sxux2ujo	303	17	cancer	cancer	NN
cord-261028-sxux2ujo	303	18	treatment	treatment	NN
cord-261028-sxux2ujo	303	19	for	for	IN
cord-261028-sxux2ujo	303	20	local	local	JJ
cord-261028-sxux2ujo	303	21	tumor	tumor	NN
cord-261028-sxux2ujo	303	22	control	control	NN
cord-261028-sxux2ujo	303	23	for	for	IN
cord-261028-sxux2ujo	303	24	over	over	IN
cord-261028-sxux2ujo	303	25	a	a	DT
cord-261028-sxux2ujo	303	26	century	century	NN
cord-261028-sxux2ujo	303	27	.	.	.
cord-261028-sxux2ujo	304	1	Cytotoxicity	cytotoxicity	NN
cord-261028-sxux2ujo	304	2	through	through	IN
cord-261028-sxux2ujo	304	3	damage	damage	NN
cord-261028-sxux2ujo	304	4	of	of	IN
cord-261028-sxux2ujo	304	5	genomic	genomic	JJ
cord-261028-sxux2ujo	304	6	DNA	dna	NN
cord-261028-sxux2ujo	304	7	is	be	VBZ
cord-261028-sxux2ujo	304	8	thought	think	VBN
cord-261028-sxux2ujo	304	9	to	to	TO
cord-261028-sxux2ujo	304	10	be	be	VB
cord-261028-sxux2ujo	304	11	the	the	DT
cord-261028-sxux2ujo	304	12	principal	principal	JJ
cord-261028-sxux2ujo	304	13	mechanism	mechanism	NN
cord-261028-sxux2ujo	304	14	for	for	IN
cord-261028-sxux2ujo	304	15	the	the	DT
cord-261028-sxux2ujo	304	16	effects	effect	NNS
cord-261028-sxux2ujo	304	17	of	of	IN
cord-261028-sxux2ujo	304	18	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	304	19	,	,	,
cord-261028-sxux2ujo	304	20	but	but	CC
cord-261028-sxux2ujo	304	21	more	more	RBR
cord-261028-sxux2ujo	304	22	recently	recently	RB
cord-261028-sxux2ujo	304	23	evidence	evidence	NN
cord-261028-sxux2ujo	304	24	has	have	VBZ
cord-261028-sxux2ujo	304	25	emerged	emerge	VBN
cord-261028-sxux2ujo	304	26	that	that	IN
cord-261028-sxux2ujo	304	27	implicates	implicate	VBZ
cord-261028-sxux2ujo	304	28	the	the	DT
cord-261028-sxux2ujo	304	29	immune	immune	JJ
cord-261028-sxux2ujo	304	30	system	system	NN
cord-261028-sxux2ujo	304	31	in	in	IN
cord-261028-sxux2ujo	304	32	tumor	tumor	NN
cord-261028-sxux2ujo	304	33	control	control	NN
cord-261028-sxux2ujo	304	34	mediated	mediate	VBN
cord-261028-sxux2ujo	304	35	by	by	IN
cord-261028-sxux2ujo	304	36	radiation	radiation	NN
cord-261028-sxux2ujo	304	37	(	(	-LRB-
cord-261028-sxux2ujo	304	38	Apetoh	Apetoh	NNP
cord-261028-sxux2ujo	304	39	et	et	FW
cord-261028-sxux2ujo	304	40	al	al	NNP
cord-261028-sxux2ujo	304	41	.	.	NNP
cord-261028-sxux2ujo	304	42	,	,	,
cord-261028-sxux2ujo	304	43	2007	2007	CD
cord-261028-sxux2ujo	304	44	;	;	:
cord-261028-sxux2ujo	304	45	Burnette	Burnette	NNP
cord-261028-sxux2ujo	304	46	and	and	CC
cord-261028-sxux2ujo	304	47	Weichselbaum	Weichselbaum	NNP
cord-261028-sxux2ujo	304	48	,	,	,
cord-261028-sxux2ujo	304	49	2013	2013	CD
cord-261028-sxux2ujo	304	50	;	;	:
cord-261028-sxux2ujo	304	51	Burnette	Burnette	NNP
cord-261028-sxux2ujo	304	52	et	et	NNP
cord-261028-sxux2ujo	304	53	al	al	NNP
cord-261028-sxux2ujo	304	54	.	.	NNP
cord-261028-sxux2ujo	304	55	,	,	,
cord-261028-sxux2ujo	304	56	2011	2011	CD
cord-261028-sxux2ujo	304	57	;	;	:
cord-261028-sxux2ujo	304	58	Lee	Lee	NNP
cord-261028-sxux2ujo	304	59	et	et	NNP
cord-261028-sxux2ujo	304	60	al	al	NNP
cord-261028-sxux2ujo	304	61	.	.	NNP
cord-261028-sxux2ujo	304	62	,	,	,
cord-261028-sxux2ujo	304	63	2009	2009	CD
cord-261028-sxux2ujo	304	64	)	)	-RRB-
cord-261028-sxux2ujo	304	65	.	.	.
cord-261028-sxux2ujo	305	1	Furthermore	furthermore	RB
cord-261028-sxux2ujo	305	2	,	,	,
cord-261028-sxux2ujo	305	3	focal	focal	JJ
cord-261028-sxux2ujo	305	4	irradiation	irradiation	NN
cord-261028-sxux2ujo	305	5	of	of	IN
cord-261028-sxux2ujo	305	6	tumors	tumor	NNS
cord-261028-sxux2ujo	305	7	activates	activate	VBZ
cord-261028-sxux2ujo	305	8	DCs	dc	NNS
cord-261028-sxux2ujo	305	9	and	and	CC
cord-261028-sxux2ujo	305	10	induces	induce	VBZ
cord-261028-sxux2ujo	305	11	cross	cross	NN
cord-261028-sxux2ujo	305	12	-	-	JJ
cord-261028-sxux2ujo	305	13	priming	priming	NN
cord-261028-sxux2ujo	305	14	of	of	IN
cord-261028-sxux2ujo	305	15	tumor	tumor	NN
cord-261028-sxux2ujo	305	16	specific	specific	JJ
cord-261028-sxux2ujo	305	17	T	t	NN
cord-261028-sxux2ujo	305	18	cells	cell	NNS
cord-261028-sxux2ujo	305	19	that	that	WDT
cord-261028-sxux2ujo	305	20	mediate	mediate	VBP
cord-261028-sxux2ujo	305	21	systemic	systemic	JJ
cord-261028-sxux2ujo	305	22	anti	anti	JJ
cord-261028-sxux2ujo	305	23	-	-	JJ
cord-261028-sxux2ujo	305	24	tumor	tumor	JJ
cord-261028-sxux2ujo	305	25	immunity	immunity	NN
cord-261028-sxux2ujo	305	26	(	(	-LRB-
cord-261028-sxux2ujo	305	27	Demaria	Demaria	NNP
cord-261028-sxux2ujo	305	28	et	et	NNP
cord-261028-sxux2ujo	305	29	al	al	NNP
cord-261028-sxux2ujo	305	30	.	.	NNP
cord-261028-sxux2ujo	305	31	,	,	,
cord-261028-sxux2ujo	305	32	2004	2004	CD
cord-261028-sxux2ujo	305	33	;	;	:
cord-261028-sxux2ujo	305	34	Gupta	Gupta	NNP
cord-261028-sxux2ujo	305	35	et	et	NNP
cord-261028-sxux2ujo	305	36	al	al	NNP
cord-261028-sxux2ujo	305	37	.	.	NNP
cord-261028-sxux2ujo	305	38	,	,	,
cord-261028-sxux2ujo	305	39	2012	2012	CD
cord-261028-sxux2ujo	305	40	;	;	:
cord-261028-sxux2ujo	305	41	Lim	Lim	NNP
cord-261028-sxux2ujo	305	42	et	et	NNP
cord-261028-sxux2ujo	305	43	al	al	NNP
cord-261028-sxux2ujo	305	44	.	.	NNP
cord-261028-sxux2ujo	305	45	,	,	,
cord-261028-sxux2ujo	305	46	2014	2014	CD
cord-261028-sxux2ujo	306	1	;	;	:
cord-261028-sxux2ujo	306	2	Lugade	Lugade	NNP
cord-261028-sxux2ujo	306	3	et	et	NNP
cord-261028-sxux2ujo	306	4	al	al	NNP
cord-261028-sxux2ujo	306	5	.	.	NNP
cord-261028-sxux2ujo	306	6	,	,	,
cord-261028-sxux2ujo	306	7	2005	2005	CD
cord-261028-sxux2ujo	306	8	;	;	:
cord-261028-sxux2ujo	307	1	Weichselbaum	Weichselbaum	NNP
cord-261028-sxux2ujo	307	2	et	et	NNP
cord-261028-sxux2ujo	307	3	al	al	NNP
cord-261028-sxux2ujo	307	4	.	.	NNP
cord-261028-sxux2ujo	307	5	,	,	,
cord-261028-sxux2ujo	307	6	2017	2017	CD
cord-261028-sxux2ujo	307	7	)	)	-RRB-
cord-261028-sxux2ujo	307	8	.	.	.
cord-261028-sxux2ujo	308	1	This	this	DT
cord-261028-sxux2ujo	308	2	radiation	radiation	NN
cord-261028-sxux2ujo	308	3	induced	induce	VBD
cord-261028-sxux2ujo	308	4	anti	anti	JJ
cord-261028-sxux2ujo	308	5	-	-	JJ
cord-261028-sxux2ujo	308	6	tumor	tumor	JJ
cord-261028-sxux2ujo	308	7	immune	immune	JJ
cord-261028-sxux2ujo	308	8	response	response	NN
cord-261028-sxux2ujo	308	9	is	be	VBZ
cord-261028-sxux2ujo	308	10	dependent	dependent	JJ
cord-261028-sxux2ujo	308	11	on	on	IN
cord-261028-sxux2ujo	308	12	STING	sting	NN
cord-261028-sxux2ujo	308	13	and	and	CC
cord-261028-sxux2ujo	308	14	its	-PRON-	PRP$
cord-261028-sxux2ujo	308	15	upstream	upstream	JJ
cord-261028-sxux2ujo	308	16	mediator	mediator	NN
cord-261028-sxux2ujo	308	17	cGAS	cgas	NN
cord-261028-sxux2ujo	309	1	(	(	-LRB-
cord-261028-sxux2ujo	309	2	Deng	Deng	NNP
cord-261028-sxux2ujo	309	3	et	et	NNP
cord-261028-sxux2ujo	309	4	al	al	NNP
cord-261028-sxux2ujo	309	5	.	.	NNP
cord-261028-sxux2ujo	309	6	,	,	,
cord-261028-sxux2ujo	309	7	2014a	2014a	CD
cord-261028-sxux2ujo	309	8	)	)	-RRB-
cord-261028-sxux2ujo	309	9	.	.	.
cord-261028-sxux2ujo	310	1	Tumors	tumor	NNS
cord-261028-sxux2ujo	310	2	in	in	IN
cord-261028-sxux2ujo	310	3	mice	mouse	NNS
cord-261028-sxux2ujo	310	4	lacking	lack	VBG
cord-261028-sxux2ujo	310	5	these	these	DT
cord-261028-sxux2ujo	310	6	genes	gene	NNS
cord-261028-sxux2ujo	310	7	are	be	VBP
cord-261028-sxux2ujo	310	8	not	not	RB
cord-261028-sxux2ujo	310	9	controlled	control	VBN
cord-261028-sxux2ujo	310	10	by	by	IN
cord-261028-sxux2ujo	310	11	an	an	DT
cord-261028-sxux2ujo	310	12	otherwise	otherwise	RB
cord-261028-sxux2ujo	310	13	effective	effective	JJ
cord-261028-sxux2ujo	310	14	dose	dose	NN
cord-261028-sxux2ujo	310	15	of	of	IN
cord-261028-sxux2ujo	310	16	radiation	radiation	NN
cord-261028-sxux2ujo	310	17	,	,	,
cord-261028-sxux2ujo	310	18	their	-PRON-	PRP$
cord-261028-sxux2ujo	310	19	DCs	dc	NNS
cord-261028-sxux2ujo	310	20	do	do	VBP
cord-261028-sxux2ujo	310	21	not	not	RB
cord-261028-sxux2ujo	310	22	produce	produce	VB
cord-261028-sxux2ujo	310	23	type	type	NN
cord-261028-sxux2ujo	311	1	I	-PRON-	PRP
cord-261028-sxux2ujo	311	2	IFN	IFN	NNP
cord-261028-sxux2ujo	311	3	in	in	IN
cord-261028-sxux2ujo	311	4	response	response	NN
cord-261028-sxux2ujo	311	5	to	to	IN
cord-261028-sxux2ujo	311	6	radiation	radiation	NN
cord-261028-sxux2ujo	311	7	,	,	,
cord-261028-sxux2ujo	311	8	and	and	CC
cord-261028-sxux2ujo	312	1	there	there	EX
cord-261028-sxux2ujo	312	2	is	be	VBZ
cord-261028-sxux2ujo	312	3	a	a	DT
cord-261028-sxux2ujo	312	4	defect	defect	NN
cord-261028-sxux2ujo	312	5	in	in	IN
cord-261028-sxux2ujo	312	6	cross	cross	NN
cord-261028-sxux2ujo	312	7	-	-	JJ
cord-261028-sxux2ujo	312	8	priming	priming	NN
cord-261028-sxux2ujo	312	9	of	of	IN
cord-261028-sxux2ujo	312	10	tumor	tumor	NN
cord-261028-sxux2ujo	312	11	specific	specific	JJ
cord-261028-sxux2ujo	312	12	CD8	CD8	NNP
cord-261028-sxux2ujo	312	13	+	+	CC
cord-261028-sxux2ujo	312	14	T	t	NN
cord-261028-sxux2ujo	312	15	cells	cell	NNS
cord-261028-sxux2ujo	312	16	after	after	IN
cord-261028-sxux2ujo	312	17	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	312	18	.	.	.
cord-261028-sxux2ujo	313	1	to	to	IN
cord-261028-sxux2ujo	313	2	radiation	radiation	NN
cord-261028-sxux2ujo	313	3	therapy	therapy	NN
cord-261028-sxux2ujo	313	4	,	,	,
cord-261028-sxux2ujo	313	5	many	many	JJ
cord-261028-sxux2ujo	313	6	antineoplastic	antineoplastic	JJ
cord-261028-sxux2ujo	313	7	chemotherapy	chemotherapy	NN
cord-261028-sxux2ujo	313	8	agents	agent	NNS
cord-261028-sxux2ujo	313	9	induce	induce	VBP
cord-261028-sxux2ujo	313	10	cytotoxicity	cytotoxicity	NN
cord-261028-sxux2ujo	313	11	by	by	IN
cord-261028-sxux2ujo	313	12	damaging	damage	VBG
cord-261028-sxux2ujo	313	13	chromosomal	chromosomal	JJ
cord-261028-sxux2ujo	313	14	DNA	dna	NN
cord-261028-sxux2ujo	313	15	.	.	.
cord-261028-sxux2ujo	314	1	Fibroblasts	fibroblast	NNS
cord-261028-sxux2ujo	314	2	treated	treat	VBN
cord-261028-sxux2ujo	314	3	with	with	IN
cord-261028-sxux2ujo	314	4	Ara	Ara	NNP
cord-261028-sxux2ujo	314	5	-	-	HYPH
cord-261028-sxux2ujo	314	6	C	C	NNP
cord-261028-sxux2ujo	314	7	undergo	undergo	VBP
cord-261028-sxux2ujo	314	8	DNA	dna	NN
cord-261028-sxux2ujo	314	9	damage	damage	NN
cord-261028-sxux2ujo	314	10	with	with	IN
cord-261028-sxux2ujo	314	11	nuclear	nuclear	JJ
cord-261028-sxux2ujo	314	12	DNA	dna	NN
cord-261028-sxux2ujo	314	13	transported	transport	VBN
cord-261028-sxux2ujo	314	14	into	into	IN
cord-261028-sxux2ujo	314	15	the	the	DT
cord-261028-sxux2ujo	314	16	cytosol	cytosol	NN
cord-261028-sxux2ujo	314	17	which	which	WDT
cord-261028-sxux2ujo	314	18	can	can	MD
cord-261028-sxux2ujo	314	19	be	be	VB
cord-261028-sxux2ujo	314	20	sensed	sense	VBN
cord-261028-sxux2ujo	314	21	by	by	IN
cord-261028-sxux2ujo	314	22	STING	sting	NN
cord-261028-sxux2ujo	314	23	,	,	,
cord-261028-sxux2ujo	314	24	triggering	trigger	VBG
cord-261028-sxux2ujo	314	25	a	a	DT
cord-261028-sxux2ujo	314	26	type	type	NN
cord-261028-sxux2ujo	315	1	I	-PRON-	PRP
cord-261028-sxux2ujo	316	1	interferon	interferon	NNP
cord-261028-sxux2ujo	316	2	response	response	NN
cord-261028-sxux2ujo	316	3	(	(	-LRB-
cord-261028-sxux2ujo	316	4	Lan	Lan	NNP
cord-261028-sxux2ujo	316	5	et	et	FW
cord-261028-sxux2ujo	316	6	al	al	NNP
cord-261028-sxux2ujo	316	7	.	.	NNP
cord-261028-sxux2ujo	316	8	,	,	,
cord-261028-sxux2ujo	316	9	2014	2014	CD
cord-261028-sxux2ujo	316	10	)	)	-RRB-
cord-261028-sxux2ujo	316	11	.	.	.
cord-261028-sxux2ujo	317	1	Chemotherapy	chemotherapy	NN
cord-261028-sxux2ujo	317	2	agents	agent	NNS
cord-261028-sxux2ujo	317	3	such	such	JJ
cord-261028-sxux2ujo	317	4	as	as	IN
cord-261028-sxux2ujo	317	5	etoposide	etoposide	NN
cord-261028-sxux2ujo	317	6	can	can	MD
cord-261028-sxux2ujo	317	7	also	also	RB
cord-261028-sxux2ujo	317	8	have	have	VB
cord-261028-sxux2ujo	317	9	direct	direct	JJ
cord-261028-sxux2ujo	317	10	affects	affect	NNS
cord-261028-sxux2ujo	317	11	on	on	IN
cord-261028-sxux2ujo	317	12	DCs	dc	NNS
cord-261028-sxux2ujo	317	13	causing	cause	VBG
cord-261028-sxux2ujo	317	14	DNA	dna	NN
cord-261028-sxux2ujo	317	15	damage	damage	NN
cord-261028-sxux2ujo	317	16	and	and	CC
cord-261028-sxux2ujo	317	17	transport	transport	NN
cord-261028-sxux2ujo	317	18	of	of	IN
cord-261028-sxux2ujo	317	19	DNA	dna	NN
cord-261028-sxux2ujo	317	20	to	to	IN
cord-261028-sxux2ujo	317	21	the	the	DT
cord-261028-sxux2ujo	317	22	cytosol	cytosol	NN
cord-261028-sxux2ujo	317	23	which	which	WDT
cord-261028-sxux2ujo	317	24	also	also	RB
cord-261028-sxux2ujo	317	25	elicits	elicit	VBZ
cord-261028-sxux2ujo	317	26	a	a	DT
cord-261028-sxux2ujo	317	27	STING	sting	NN
cord-261028-sxux2ujo	317	28	-	-	HYPH
cord-261028-sxux2ujo	317	29	dependent	dependent	JJ
cord-261028-sxux2ujo	317	30	Type	type	NN
cord-261028-sxux2ujo	317	31	I	-PRON-	PRP
cord-261028-sxux2ujo	317	32	interferon	interferon	VBD
cord-261028-sxux2ujo	317	33	response	response	NN
cord-261028-sxux2ujo	317	34	.	.	.
cord-261028-sxux2ujo	318	1	Different	different	JJ
cord-261028-sxux2ujo	318	2	classes	class	NNS
cord-261028-sxux2ujo	318	3	of	of	IN
cord-261028-sxux2ujo	318	4	chemotherapy	chemotherapy	NN
cord-261028-sxux2ujo	318	5	agents	agent	NNS
cord-261028-sxux2ujo	318	6	induce	induce	VBP
cord-261028-sxux2ujo	318	7	differing	differ	VBG
cord-261028-sxux2ujo	318	8	types	type	NNS
cord-261028-sxux2ujo	318	9	of	of	IN
cord-261028-sxux2ujo	318	10	DNA	dna	NN
cord-261028-sxux2ujo	318	11	damage	damage	NN
cord-261028-sxux2ujo	318	12	,	,	,
cord-261028-sxux2ujo	318	13	and	and	CC
cord-261028-sxux2ujo	318	14	one	one	PRP
cord-261028-sxux2ujo	318	15	can	can	MD
cord-261028-sxux2ujo	318	16	speculate	speculate	VB
cord-261028-sxux2ujo	318	17	that	that	IN
cord-261028-sxux2ujo	318	18	chemotherapeutic	chemotherapeutic	JJ
cord-261028-sxux2ujo	318	19	agents	agent	NNS
cord-261028-sxux2ujo	318	20	that	that	WDT
cord-261028-sxux2ujo	318	21	support	support	VBP
cord-261028-sxux2ujo	318	22	the	the	DT
cord-261028-sxux2ujo	318	23	formation	formation	NN
cord-261028-sxux2ujo	318	24	of	of	IN
cord-261028-sxux2ujo	318	25	ligands	ligand	NNS
cord-261028-sxux2ujo	318	26	for	for	IN
cord-261028-sxux2ujo	318	27	the	the	DT
cord-261028-sxux2ujo	318	28	STING	sting	NN
cord-261028-sxux2ujo	318	29	pathway	pathway	NN
cord-261028-sxux2ujo	318	30	would	would	MD
cord-261028-sxux2ujo	318	31	provide	provide	VB
cord-261028-sxux2ujo	318	32	clinical	clinical	JJ
cord-261028-sxux2ujo	318	33	benefits	benefit	NNS
cord-261028-sxux2ujo	318	34	by	by	IN
cord-261028-sxux2ujo	318	35	facilitating	facilitate	VBG
cord-261028-sxux2ujo	318	36	anti	anti	JJ
cord-261028-sxux2ujo	318	37	-	-	JJ
cord-261028-sxux2ujo	318	38	tumor	tumor	JJ
cord-261028-sxux2ujo	318	39	immunity	immunity	NN
cord-261028-sxux2ujo	318	40	.	.	.
cord-261028-sxux2ujo	319	1	However	however	RB
cord-261028-sxux2ujo	319	2	,	,	,
cord-261028-sxux2ujo	319	3	there	there	EX
cord-261028-sxux2ujo	319	4	is	be	VBZ
cord-261028-sxux2ujo	319	5	currently	currently	RB
cord-261028-sxux2ujo	319	6	little	little	RB
cord-261028-sxux2ujo	319	7	known	known	JJ
cord-261028-sxux2ujo	319	8	on	on	IN
cord-261028-sxux2ujo	319	9	the	the	DT
cord-261028-sxux2ujo	319	10	induction	induction	NN
cord-261028-sxux2ujo	319	11	of	of	IN
cord-261028-sxux2ujo	319	12	STING	sting	NN
cord-261028-sxux2ujo	319	13	ligands	ligand	NNS
cord-261028-sxux2ujo	319	14	and	and	CC
cord-261028-sxux2ujo	319	15	type	type	NN
cord-261028-sxux2ujo	319	16	I	-PRON-	PRP
cord-261028-sxux2ujo	319	17	IFN	IFN	NNP
cord-261028-sxux2ujo	319	18	inducing	induce	VBG
cord-261028-sxux2ujo	319	19	capacity	capacity	NN
cord-261028-sxux2ujo	319	20	of	of	IN
cord-261028-sxux2ujo	319	21	the	the	DT
cord-261028-sxux2ujo	319	22	main	main	JJ
cord-261028-sxux2ujo	319	23	DNA	dna	NN
cord-261028-sxux2ujo	319	24	damaging	damage	VBG
cord-261028-sxux2ujo	319	25	chemotherapy	chemotherapy	NN
cord-261028-sxux2ujo	319	26	agents	agent	NNS
cord-261028-sxux2ujo	319	27	.	.	.
cord-261028-sxux2ujo	320	1	,	,	,
cord-261028-sxux2ujo	320	2	recent	recent	JJ
cord-261028-sxux2ujo	320	3	studies	study	NNS
cord-261028-sxux2ujo	320	4	indicate	indicate	VBP
cord-261028-sxux2ujo	320	5	that	that	IN
cord-261028-sxux2ujo	320	6	not	not	RB
cord-261028-sxux2ujo	320	7	all	all	DT
cord-261028-sxux2ujo	320	8	of	of	IN
cord-261028-sxux2ujo	320	9	the	the	DT
cord-261028-sxux2ujo	320	10	effects	effect	NNS
cord-261028-sxux2ujo	320	11	of	of	IN
cord-261028-sxux2ujo	320	12	STING	sting	NN
cord-261028-sxux2ujo	320	13	activation	activation	NN
cord-261028-sxux2ujo	320	14	promote	promote	VBP
cord-261028-sxux2ujo	320	15	tumor	tumor	NN
cord-261028-sxux2ujo	320	16	immunity	immunity	NN
cord-261028-sxux2ujo	320	17	and	and	CC
cord-261028-sxux2ujo	320	18	protection	protection	NN
cord-261028-sxux2ujo	320	19	.	.	.
cord-261028-sxux2ujo	321	1	STING	sting	NN
cord-261028-sxux2ujo	321	2	agonists	agonist	NNS
cord-261028-sxux2ujo	321	3	can	can	MD
cord-261028-sxux2ujo	321	4	also	also	RB
cord-261028-sxux2ujo	321	5	promote	promote	VB
cord-261028-sxux2ujo	321	6	oncogenesis	oncogenesis	NN
cord-261028-sxux2ujo	321	7	,	,	,
cord-261028-sxux2ujo	321	8	for	for	IN
cord-261028-sxux2ujo	321	9	example	example	NN
cord-261028-sxux2ujo	321	10	mice	mouse	NNS
cord-261028-sxux2ujo	321	11	treated	treat	VBD
cord-261028-sxux2ujo	321	12	cutaneously	cutaneously	NN
cord-261028-sxux2ujo	321	13	with	with	IN
cord-261028-sxux2ujo	321	14	7,12-dimethylbenz[a]anthracene	7,12-dimethylbenz[a]anthracene	CD
cord-261028-sxux2ujo	321	15	(	(	-LRB-
cord-261028-sxux2ujo	321	16	DMBA	DMBA	NNS
cord-261028-sxux2ujo	321	17	)	)	-RRB-
cord-261028-sxux2ujo	322	1	develop	develop	VB
cord-261028-sxux2ujo	322	2	inflammation	inflammation	NN
cord-261028-sxux2ujo	322	3	and	and	CC
cord-261028-sxux2ujo	322	4	skin	skin	NN
cord-261028-sxux2ujo	322	5	cancer	cancer	NN
cord-261028-sxux2ujo	322	6	which	which	WDT
cord-261028-sxux2ujo	322	7	is	be	VBZ
cord-261028-sxux2ujo	322	8	mediated	mediate	VBN
cord-261028-sxux2ujo	322	9	by	by	IN
cord-261028-sxux2ujo	322	10	STING	sting	NN
cord-261028-sxux2ujo	323	1	(	(	-LRB-
cord-261028-sxux2ujo	323	2	Ahn	Ahn	NNP
cord-261028-sxux2ujo	323	3	et	et	NNP
cord-261028-sxux2ujo	323	4	al	al	NNP
cord-261028-sxux2ujo	323	5	.	.	NNP
cord-261028-sxux2ujo	323	6	,	,	,
cord-261028-sxux2ujo	323	7	2014	2014	CD
cord-261028-sxux2ujo	323	8	)	)	-RRB-
cord-261028-sxux2ujo	323	9	.	.	.
cord-261028-sxux2ujo	324	1	STING	STING	NNP
cord-261028-sxux2ujo	324	2	can	can	MD
cord-261028-sxux2ujo	324	3	also	also	RB
cord-261028-sxux2ujo	324	4	modify	modify	VB
cord-261028-sxux2ujo	324	5	the	the	DT
cord-261028-sxux2ujo	324	6	tumor	tumor	NN
cord-261028-sxux2ujo	324	7	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	324	8	to	to	TO
cord-261028-sxux2ujo	324	9	become	become	VB
cord-261028-sxux2ujo	324	10	more	more	JJR
cord-261028-sxux2ujo	324	11	tolerogenic	tolerogenic	JJ
cord-261028-sxux2ujo	324	12	promoting	promote	VBG
cord-261028-sxux2ujo	324	13	tumor	tumor	NN
cord-261028-sxux2ujo	324	14	progression	progression	NN
cord-261028-sxux2ujo	324	15	and	and	CC
cord-261028-sxux2ujo	324	16	metastasis	metastasis	NN
cord-261028-sxux2ujo	324	17	through	through	IN
cord-261028-sxux2ujo	324	18	induction	induction	NN
cord-261028-sxux2ujo	324	19	of	of	IN
cord-261028-sxux2ujo	324	20	IDO	IDO	NNP
cord-261028-sxux2ujo	324	21	which	which	WDT
cord-261028-sxux2ujo	324	22	promotes	promote	VBZ
cord-261028-sxux2ujo	324	23	Treg	Treg	NNP
cord-261028-sxux2ujo	324	24	function	function	NN
cord-261028-sxux2ujo	324	25	and	and	CC
cord-261028-sxux2ujo	324	26	immune	immune	JJ
cord-261028-sxux2ujo	324	27	tolerance	tolerance	NN
cord-261028-sxux2ujo	324	28	of	of	IN
cord-261028-sxux2ujo	324	29	tumors	tumor	NNS
cord-261028-sxux2ujo	324	30	by	by	IN
cord-261028-sxux2ujo	324	31	cytokines	cytokine	NNS
cord-261028-sxux2ujo	324	32	such	such	JJ
cord-261028-sxux2ujo	324	33	as	as	IN
cord-261028-sxux2ujo	324	34	IL-10	IL-10	NNP
cord-261028-sxux2ujo	324	35	and	and	CC
cord-261028-sxux2ujo	324	36	TGF	TGF	NNP
cord-261028-sxux2ujo	324	37	-	-	HYPH
cord-261028-sxux2ujo	324	38	β	β	NNP
cord-261028-sxux2ujo	324	39	(	(	-LRB-
cord-261028-sxux2ujo	324	40	Lemos	Lemos	NNP
cord-261028-sxux2ujo	324	41	et	et	NNP
cord-261028-sxux2ujo	324	42	al	al	NNP
cord-261028-sxux2ujo	324	43	.	.	.
cord-261028-sxux2ujo	325	1	,	,	,
cord-261028-sxux2ujo	325	2	2016	2016	CD
cord-261028-sxux2ujo	325	3	;	;	:
cord-261028-sxux2ujo	325	4	Huang	Huang	NNP
cord-261028-sxux2ujo	325	5	et	et	NNP
cord-261028-sxux2ujo	325	6	al	al	NNP
cord-261028-sxux2ujo	325	7	.	.	NNP
cord-261028-sxux2ujo	325	8	,	,	,
cord-261028-sxux2ujo	325	9	2013	2013	CD
cord-261028-sxux2ujo	325	10	)	)	-RRB-
cord-261028-sxux2ujo	325	11	.	.	.
cord-261028-sxux2ujo	326	1	At	at	IN
cord-261028-sxux2ujo	326	2	this	this	DT
cord-261028-sxux2ujo	326	3	point	point	NN
cord-261028-sxux2ujo	326	4	it	-PRON-	PRP
cord-261028-sxux2ujo	326	5	is	be	VBZ
cord-261028-sxux2ujo	326	6	not	not	RB
cord-261028-sxux2ujo	326	7	clear	clear	JJ
cord-261028-sxux2ujo	326	8	why	why	WRB
cord-261028-sxux2ujo	326	9	or	or	CC
cord-261028-sxux2ujo	326	10	under	under	IN
cord-261028-sxux2ujo	326	11	which	which	WDT
cord-261028-sxux2ujo	326	12	circumstances	circumstance	NNS
cord-261028-sxux2ujo	326	13	STING	sting	VB
cord-261028-sxux2ujo	326	14	and	and	CC
cord-261028-sxux2ujo	326	15	type	type	NN
cord-261028-sxux2ujo	327	1	I	-PRON-	PRP
cord-261028-sxux2ujo	327	2	IFN	IFN	NNP
cord-261028-sxux2ujo	327	3	promotes	promote	VBZ
cord-261028-sxux2ujo	327	4	or	or	CC
cord-261028-sxux2ujo	327	5	suppresses	suppress	VBZ
cord-261028-sxux2ujo	327	6	anti	anti	JJ
cord-261028-sxux2ujo	327	7	-	-	JJ
cord-261028-sxux2ujo	327	8	tumor	tumor	JJ
cord-261028-sxux2ujo	327	9	immunity	immunity	NN
cord-261028-sxux2ujo	327	10	,	,	,
cord-261028-sxux2ujo	327	11	although	although	IN
cord-261028-sxux2ujo	327	12	chronic	chronic	JJ
cord-261028-sxux2ujo	327	13	inflammation	inflammation	NN
cord-261028-sxux2ujo	327	14	is	be	VBZ
cord-261028-sxux2ujo	327	15	a	a	DT
cord-261028-sxux2ujo	327	16	well	well	RB
cord-261028-sxux2ujo	327	17	accepted	accept	VBN
cord-261028-sxux2ujo	327	18	stimulus	stimulus	NN
cord-261028-sxux2ujo	327	19	of	of	IN
cord-261028-sxux2ujo	327	20	oncogenesis	oncogenesis	NNP
cord-261028-sxux2ujo	327	21	,	,	,
cord-261028-sxux2ujo	327	22	and	and	CC
cord-261028-sxux2ujo	327	23	one	one	PRP
cord-261028-sxux2ujo	327	24	can	can	MD
cord-261028-sxux2ujo	327	25	speculate	speculate	VB
cord-261028-sxux2ujo	327	26	that	that	IN
cord-261028-sxux2ujo	327	27	the	the	DT
cord-261028-sxux2ujo	327	28	complex	complex	JJ
cord-261028-sxux2ujo	327	29	tumor	tumor	NN
cord-261028-sxux2ujo	327	30	micro	micro	NN
cord-261028-sxux2ujo	327	31	-	-	NN
cord-261028-sxux2ujo	327	32	environment	environment	NN
cord-261028-sxux2ujo	327	33	with	with	IN
cord-261028-sxux2ujo	327	34	its	-PRON-	PRP$
cord-261028-sxux2ujo	327	35	various	various	JJ
cord-261028-sxux2ujo	327	36	regulatory	regulatory	JJ
cord-261028-sxux2ujo	327	37	components	component	NNS
cord-261028-sxux2ujo	327	38	such	such	JJ
cord-261028-sxux2ujo	327	39	as	as	IN
cord-261028-sxux2ujo	327	40	Tregs	Tregs	NNP
cord-261028-sxux2ujo	327	41	,	,	,
cord-261028-sxux2ujo	327	42	myeloid	myeloid	NN
cord-261028-sxux2ujo	327	43	derived	derive	VBN
cord-261028-sxux2ujo	327	44	suppressor	suppressor	NN
cord-261028-sxux2ujo	327	45	cells	cell	NNS
cord-261028-sxux2ujo	327	46	,	,	,
cord-261028-sxux2ujo	327	47	and	and	CC
cord-261028-sxux2ujo	327	48	macrophages	macrophage	NNS
cord-261028-sxux2ujo	327	49	may	may	MD
cord-261028-sxux2ujo	327	50	help	help	VB
cord-261028-sxux2ujo	327	51	determine	determine	VB
cord-261028-sxux2ujo	327	52	the	the	DT
cord-261028-sxux2ujo	327	53	effects	effect	NNS
cord-261028-sxux2ujo	327	54	of	of	IN
cord-261028-sxux2ujo	327	55	IFN	IFN	NNP
cord-261028-sxux2ujo	327	56	stimulation	stimulation	NN
cord-261028-sxux2ujo	327	57	.	.	.
cord-261028-sxux2ujo	328	1	In	in	IN
cord-261028-sxux2ujo	328	2	recent	recent	JJ
cord-261028-sxux2ujo	328	3	years	year	NNS
cord-261028-sxux2ujo	328	4	,	,	,
cord-261028-sxux2ujo	328	5	pharmacologic	pharmacologic	JJ
cord-261028-sxux2ujo	328	6	agents	agent	NNS
cord-261028-sxux2ujo	328	7	that	that	WDT
cord-261028-sxux2ujo	328	8	activation	activation	VBP
cord-261028-sxux2ujo	328	9	the	the	DT
cord-261028-sxux2ujo	328	10	STING	sting	NN
cord-261028-sxux2ujo	328	11	pathway	pathway	NN
cord-261028-sxux2ujo	328	12	have	have	VBP
cord-261028-sxux2ujo	328	13	been	be	VBN
cord-261028-sxux2ujo	328	14	used	use	VBN
cord-261028-sxux2ujo	328	15	to	to	TO
cord-261028-sxux2ujo	328	16	mimic	mimic	VB
cord-261028-sxux2ujo	328	17	and	and	CC
cord-261028-sxux2ujo	328	18	augment	augment	VB
cord-261028-sxux2ujo	328	19	the	the	DT
cord-261028-sxux2ujo	328	20	role	role	NN
cord-261028-sxux2ujo	328	21	of	of	IN
cord-261028-sxux2ujo	328	22	STING	sting	NN
cord-261028-sxux2ujo	328	23	mediated	mediate	VBN
cord-261028-sxux2ujo	328	24	production	production	NN
cord-261028-sxux2ujo	328	25	of	of	IN
cord-261028-sxux2ujo	328	26	type	type	NN
cord-261028-sxux2ujo	329	1	I	-PRON-	PRP
cord-261028-sxux2ujo	329	2	IFN	IFN	NNP
cord-261028-sxux2ujo	329	3	in	in	IN
cord-261028-sxux2ujo	329	4	anti	anti	JJ
cord-261028-sxux2ujo	329	5	-	-	JJ
cord-261028-sxux2ujo	329	6	tumor	tumor	JJ
cord-261028-sxux2ujo	329	7	immunity	immunity	NN
cord-261028-sxux2ujo	329	8	.	.	.
cord-261028-sxux2ujo	330	1	Administration	administration	NN
cord-261028-sxux2ujo	330	2	of	of	IN
cord-261028-sxux2ujo	330	3	STING	sting	NN
cord-261028-sxux2ujo	330	4	ligands	ligand	NNS
cord-261028-sxux2ujo	330	5	(	(	-LRB-
cord-261028-sxux2ujo	330	6	c	c	NN
cord-261028-sxux2ujo	330	7	-	-	HYPH
cord-261028-sxux2ujo	330	8	di	di	NNP
cord-261028-sxux2ujo	330	9	-	-	HYPH
cord-261028-sxux2ujo	330	10	GMP	GMP	NNP
cord-261028-sxux2ujo	330	11	,	,	,
cord-261028-sxux2ujo	330	12	DMXAA	DMXAA	NNP
cord-261028-sxux2ujo	330	13	,	,	,
cord-261028-sxux2ujo	330	14	cGAMP	cGAMP	NNP
cord-261028-sxux2ujo	330	15	,	,	,
cord-261028-sxux2ujo	330	16	CDN	CDN	NNP
cord-261028-sxux2ujo	330	17	)	)	-RRB-
cord-261028-sxux2ujo	330	18	significantly	significantly	RB
cord-261028-sxux2ujo	330	19	improve	improve	VBP
cord-261028-sxux2ujo	330	20	anti	anti	JJ
cord-261028-sxux2ujo	330	21	-	-	JJ
cord-261028-sxux2ujo	330	22	tumor	tumor	JJ
cord-261028-sxux2ujo	330	23	responses	response	NNS
cord-261028-sxux2ujo	330	24	and	and	CC
cord-261028-sxux2ujo	330	25	animal	animal	NN
cord-261028-sxux2ujo	330	26	survival	survival	NN
cord-261028-sxux2ujo	330	27	in	in	IN
cord-261028-sxux2ujo	330	28	a	a	DT
cord-261028-sxux2ujo	330	29	diverse	diverse	JJ
cord-261028-sxux2ujo	330	30	array	array	NN
cord-261028-sxux2ujo	330	31	of	of	IN
cord-261028-sxux2ujo	330	32	mouse	mouse	NN
cord-261028-sxux2ujo	330	33	models	model	NNS
cord-261028-sxux2ujo	330	34	of	of	IN
cord-261028-sxux2ujo	330	35	solid	solid	JJ
cord-261028-sxux2ujo	330	36	and	and	CC
cord-261028-sxux2ujo	330	37	blood	blood	NN
cord-261028-sxux2ujo	330	38	borne	bear	VBN
cord-261028-sxux2ujo	330	39	cancers	cancer	NNS
cord-261028-sxux2ujo	331	1	(	(	-LRB-
cord-261028-sxux2ujo	331	2	Deng	Deng	NNP
cord-261028-sxux2ujo	331	3	et	et	FW
cord-261028-sxux2ujo	331	4	al	al	NNP
cord-261028-sxux2ujo	331	5	.	.	.
cord-261028-sxux2ujo	332	1	,	,	,
cord-261028-sxux2ujo	332	2	2014a	2014a	CD
cord-261028-sxux2ujo	332	3	;	;	:
cord-261028-sxux2ujo	332	4	Baird	Baird	NNP
cord-261028-sxux2ujo	332	5	et	et	NNP
cord-261028-sxux2ujo	332	6	al	al	NNP
cord-261028-sxux2ujo	332	7	.	.	NNP
cord-261028-sxux2ujo	332	8	,	,	,
cord-261028-sxux2ujo	332	9	2016	2016	CD
cord-261028-sxux2ujo	332	10	;	;	:
cord-261028-sxux2ujo	332	11	Chandra	Chandra	NNP
cord-261028-sxux2ujo	332	12	et	et	NNP
cord-261028-sxux2ujo	332	13	al	al	NNP
cord-261028-sxux2ujo	332	14	.	.	NNP
cord-261028-sxux2ujo	332	15	,	,	,
cord-261028-sxux2ujo	332	16	2014	2014	CD
cord-261028-sxux2ujo	332	17	;	;	:
cord-261028-sxux2ujo	332	18	Corrales	Corrales	NNP
cord-261028-sxux2ujo	332	19	et	et	NNP
cord-261028-sxux2ujo	332	20	al	al	NNP
cord-261028-sxux2ujo	332	21	.	.	NNP
cord-261028-sxux2ujo	332	22	,	,	,
cord-261028-sxux2ujo	332	23	2015	2015	CD
cord-261028-sxux2ujo	333	1	;	;	:
cord-261028-sxux2ujo	333	2	Curran	Curran	NNP
cord-261028-sxux2ujo	333	3	et	et	NNP
cord-261028-sxux2ujo	333	4	al	al	NNP
cord-261028-sxux2ujo	333	5	.	.	NNP
cord-261028-sxux2ujo	333	6	,	,	,
cord-261028-sxux2ujo	333	7	2016	2016	CD
cord-261028-sxux2ujo	333	8	)	)	-RRB-
cord-261028-sxux2ujo	333	9	.	.	.
cord-261028-sxux2ujo	334	1	DMXAA	DMXAA	NNP
cord-261028-sxux2ujo	334	2	is	be	VBZ
cord-261028-sxux2ujo	334	3	a	a	DT
cord-261028-sxux2ujo	334	4	STING	sting	NN
cord-261028-sxux2ujo	334	5	agonist	agonist	NN
cord-261028-sxux2ujo	334	6	with	with	IN
cord-261028-sxux2ujo	334	7	a	a	DT
cord-261028-sxux2ujo	334	8	multi	multi	JJ
cord-261028-sxux2ujo	334	9	-	-	JJ
cord-261028-sxux2ujo	334	10	faceted	faceted	JJ
cord-261028-sxux2ujo	334	11	effect	effect	NN
cord-261028-sxux2ujo	334	12	on	on	IN
cord-261028-sxux2ujo	334	13	the	the	DT
cord-261028-sxux2ujo	334	14	tumor	tumor	NN
cord-261028-sxux2ujo	334	15	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	334	16	,	,	,
cord-261028-sxux2ujo	334	17	and	and	CC
cord-261028-sxux2ujo	334	18	treatment	treatment	NN
cord-261028-sxux2ujo	334	19	of	of	IN
cord-261028-sxux2ujo	334	20	B16	B16	NNP
cord-261028-sxux2ujo	334	21	melanoma	melanoma	NN
cord-261028-sxux2ujo	334	22	with	with	IN
cord-261028-sxux2ujo	334	23	DMXAA	DMXAA	NNP
cord-261028-sxux2ujo	334	24	augments	augment	VBZ
cord-261028-sxux2ujo	334	25	tumor	tumor	NN
cord-261028-sxux2ujo	334	26	-	-	HYPH
cord-261028-sxux2ujo	334	27	specific	specific	JJ
cord-261028-sxux2ujo	334	28	CD8	CD8	NNP
cord-261028-sxux2ujo	334	29	+	+	CC
cord-261028-sxux2ujo	334	30	T	T	NNP
cord-261028-sxux2ujo	334	31	cell	cell	NN
cord-261028-sxux2ujo	334	32	responses	response	NNS
cord-261028-sxux2ujo	334	33	which	which	WDT
cord-261028-sxux2ujo	334	34	effectively	effectively	RB
cord-261028-sxux2ujo	334	35	immunize	immunize	VBP
cord-261028-sxux2ujo	334	36	and	and	CC
cord-261028-sxux2ujo	334	37	protect	protect	VB
cord-261028-sxux2ujo	334	38	mice	mouse	NNS
cord-261028-sxux2ujo	334	39	against	against	IN
cord-261028-sxux2ujo	334	40	future	future	JJ
cord-261028-sxux2ujo	334	41	tumor	tumor	NN
cord-261028-sxux2ujo	334	42	challenge	challenge	NN
cord-261028-sxux2ujo	334	43	.	.	.
cord-261028-sxux2ujo	335	1	Similar	similar	JJ
cord-261028-sxux2ujo	335	2	results	result	NNS
cord-261028-sxux2ujo	335	3	are	be	VBP
cord-261028-sxux2ujo	335	4	seen	see	VBN
cord-261028-sxux2ujo	335	5	in	in	IN
cord-261028-sxux2ujo	335	6	mouse	mouse	NN
cord-261028-sxux2ujo	335	7	models	model	NNS
cord-261028-sxux2ujo	335	8	of	of	IN
cord-261028-sxux2ujo	335	9	prostate	prostate	NN
cord-261028-sxux2ujo	335	10	and	and	CC
cord-261028-sxux2ujo	335	11	breast	breast	NN
cord-261028-sxux2ujo	335	12	cancer	cancer	NN
cord-261028-sxux2ujo	335	13	as	as	RB
cord-261028-sxux2ujo	335	14	well	well	RB
cord-261028-sxux2ujo	335	15	as	as	IN
cord-261028-sxux2ujo	335	16	sarcoma	sarcoma	NN
cord-261028-sxux2ujo	335	17	(	(	-LRB-
cord-261028-sxux2ujo	335	18	Baguley	Baguley	NNP
cord-261028-sxux2ujo	335	19	and	and	CC
cord-261028-sxux2ujo	335	20	Ching	Ching	NNP
cord-261028-sxux2ujo	335	21	,	,	,
cord-261028-sxux2ujo	335	22	1997	1997	CD
cord-261028-sxux2ujo	335	23	)	)	-RRB-
cord-261028-sxux2ujo	335	24	.	.	.
cord-261028-sxux2ujo	336	1	In	in	IN
cord-261028-sxux2ujo	336	2	light	light	NN
cord-261028-sxux2ujo	336	3	of	of	IN
cord-261028-sxux2ujo	336	4	these	these	DT
cord-261028-sxux2ujo	336	5	promising	promising	JJ
cord-261028-sxux2ujo	336	6	results	result	NNS
cord-261028-sxux2ujo	336	7	from	from	IN
cord-261028-sxux2ujo	336	8	the	the	DT
cord-261028-sxux2ujo	336	9	animal	animal	NN
cord-261028-sxux2ujo	336	10	models	model	NNS
cord-261028-sxux2ujo	336	11	,	,	,
cord-261028-sxux2ujo	336	12	DMXAA	DMXAA	NNP
cord-261028-sxux2ujo	336	13	was	be	VBD
cord-261028-sxux2ujo	336	14	tested	test	VBN
cord-261028-sxux2ujo	336	15	in	in	IN
cord-261028-sxux2ujo	336	16	a	a	DT
cord-261028-sxux2ujo	336	17	clinical	clinical	JJ
cord-261028-sxux2ujo	336	18	trial	trial	NN
cord-261028-sxux2ujo	336	19	of	of	IN
cord-261028-sxux2ujo	336	20	patients	patient	NNS
cord-261028-sxux2ujo	336	21	with	with	IN
cord-261028-sxux2ujo	336	22	non	non	JJ
cord-261028-sxux2ujo	336	23	-	-	JJ
cord-261028-sxux2ujo	336	24	small	small	JJ
cord-261028-sxux2ujo	336	25	cell	cell	NN
cord-261028-sxux2ujo	336	26	lung	lung	NN
cord-261028-sxux2ujo	336	27	cancer	cancer	NN
cord-261028-sxux2ujo	336	28	.	.	.
cord-261028-sxux2ujo	337	1	Unfortunately	unfortunately	RB
cord-261028-sxux2ujo	337	2	,	,	,
cord-261028-sxux2ujo	337	3	DMXAA	DMXAA	NNP
cord-261028-sxux2ujo	337	4	does	do	VBZ
cord-261028-sxux2ujo	337	5	not	not	RB
cord-261028-sxux2ujo	337	6	bind	bind	VB
cord-261028-sxux2ujo	337	7	to	to	IN
cord-261028-sxux2ujo	337	8	human	human	JJ
cord-261028-sxux2ujo	337	9	STING	sting	NN
cord-261028-sxux2ujo	337	10	and	and	CC
cord-261028-sxux2ujo	337	11	thus	thus	RB
cord-261028-sxux2ujo	337	12	was	be	VBD
cord-261028-sxux2ujo	337	13	unable	unable	JJ
cord-261028-sxux2ujo	337	14	to	to	TO
cord-261028-sxux2ujo	337	15	activate	activate	VB
cord-261028-sxux2ujo	337	16	this	this	DT
cord-261028-sxux2ujo	337	17	pathway	pathway	NN
cord-261028-sxux2ujo	337	18	,	,	,
cord-261028-sxux2ujo	337	19	resulting	result	VBG
cord-261028-sxux2ujo	337	20	in	in	IN
cord-261028-sxux2ujo	337	21	a	a	DT
cord-261028-sxux2ujo	337	22	negative	negative	JJ
cord-261028-sxux2ujo	337	23	trial	trial	NN
cord-261028-sxux2ujo	337	24	(	(	-LRB-
cord-261028-sxux2ujo	337	25	Lara	Lara	NNP
cord-261028-sxux2ujo	337	26	et	et	NNP
cord-261028-sxux2ujo	337	27	al	al	NNP
cord-261028-sxux2ujo	337	28	.	.	NNP
cord-261028-sxux2ujo	337	29	,	,	,
cord-261028-sxux2ujo	337	30	2011	2011	CD
cord-261028-sxux2ujo	337	31	;	;	:
cord-261028-sxux2ujo	337	32	Gao	Gao	NNP
cord-261028-sxux2ujo	337	33	et	et	NNP
cord-261028-sxux2ujo	337	34	al	al	NNP
cord-261028-sxux2ujo	337	35	.	.	NNP
cord-261028-sxux2ujo	337	36	,	,	,
cord-261028-sxux2ujo	337	37	2013	2013	CD
cord-261028-sxux2ujo	337	38	)	)	-RRB-
cord-261028-sxux2ujo	337	39	.	.	.
cord-261028-sxux2ujo	338	1	Another	another	DT
cord-261028-sxux2ujo	338	2	STING	sting	NN
cord-261028-sxux2ujo	338	3	agonist	agonist	NN
cord-261028-sxux2ujo	338	4	,	,	,
cord-261028-sxux2ujo	338	5	the	the	DT
cord-261028-sxux2ujo	338	6	cyclic	cyclic	JJ
cord-261028-sxux2ujo	338	7	diguanylate	diguanylate	NN
cord-261028-sxux2ujo	338	8	nucleotide	nucleotide	NN
cord-261028-sxux2ujo	338	9	(	(	-LRB-
cord-261028-sxux2ujo	338	10	CDN	CDN	NNP
cord-261028-sxux2ujo	338	11	)	)	-RRB-
cord-261028-sxux2ujo	338	12	c	c	NNP
cord-261028-sxux2ujo	338	13	-	-	HYPH
cord-261028-sxux2ujo	338	14	di	di	NNP
cord-261028-sxux2ujo	338	15	-	-	HYPH
cord-261028-sxux2ujo	338	16	GMP	GMP	NNP
cord-261028-sxux2ujo	338	17	,	,	,
cord-261028-sxux2ujo	338	18	is	be	VBZ
cord-261028-sxux2ujo	338	19	effective	effective	JJ
cord-261028-sxux2ujo	338	20	in	in	IN
cord-261028-sxux2ujo	338	21	the	the	DT
cord-261028-sxux2ujo	338	22	treatment	treatment	NN
cord-261028-sxux2ujo	338	23	of	of	IN
cord-261028-sxux2ujo	338	24	4T1	4t1	CD
cord-261028-sxux2ujo	338	25	mammary	mammary	JJ
cord-261028-sxux2ujo	338	26	carcinoma	carcinoma	NN
cord-261028-sxux2ujo	338	27	.	.	.
cord-261028-sxux2ujo	339	1	A	a	DT
cord-261028-sxux2ujo	339	2	synthetic	synthetic	JJ
cord-261028-sxux2ujo	339	3	CDN	CDN	NNP
cord-261028-sxux2ujo	339	4	agonist	agonist	NN
cord-261028-sxux2ujo	339	5	MLRR	MLRR	NNP
cord-261028-sxux2ujo	339	6	-	-	HYPH
cord-261028-sxux2ujo	339	7	S2	S2	NNP
cord-261028-sxux2ujo	339	8	CDA	CDA	NNP
cord-261028-sxux2ujo	339	9	has	have	VBZ
cord-261028-sxux2ujo	339	10	high	high	JJ
cord-261028-sxux2ujo	339	11	affinity	affinity	NN
cord-261028-sxux2ujo	339	12	for	for	IN
cord-261028-sxux2ujo	339	13	human	human	JJ
cord-261028-sxux2ujo	339	14	and	and	CC
cord-261028-sxux2ujo	339	15	murine	murine	JJ
cord-261028-sxux2ujo	339	16	STING	sting	NN
cord-261028-sxux2ujo	339	17	and	and	CC
cord-261028-sxux2ujo	339	18	stimulates	stimulate	VBZ
cord-261028-sxux2ujo	339	19	type	type	NN
cord-261028-sxux2ujo	340	1	I	-PRON-	PRP
cord-261028-sxux2ujo	340	2	IFN	IFN	NNP
cord-261028-sxux2ujo	340	3	production	production	NN
cord-261028-sxux2ujo	340	4	in	in	IN
cord-261028-sxux2ujo	340	5	human	human	JJ
cord-261028-sxux2ujo	340	6	PBMCs	pbmc	NNS
cord-261028-sxux2ujo	340	7	.	.	.
cord-261028-sxux2ujo	341	1	This	this	DT
cord-261028-sxux2ujo	341	2	agent	agent	NN
cord-261028-sxux2ujo	341	3	induces	induce	VBZ
cord-261028-sxux2ujo	341	4	immune	immune	JJ
cord-261028-sxux2ujo	341	5	mediated	mediate	VBN
cord-261028-sxux2ujo	341	6	tumor	tumor	NN
cord-261028-sxux2ujo	341	7	rejection	rejection	NN
cord-261028-sxux2ujo	341	8	of	of	IN
cord-261028-sxux2ujo	341	9	melanoma	melanoma	NN
cord-261028-sxux2ujo	341	10	,	,	,
cord-261028-sxux2ujo	341	11	breast	breast	NN
cord-261028-sxux2ujo	341	12	and	and	CC
cord-261028-sxux2ujo	341	13	colon	colon	NN
cord-261028-sxux2ujo	341	14	carcinoma	carcinoma	NN
cord-261028-sxux2ujo	341	15	in	in	IN
cord-261028-sxux2ujo	341	16	mice	mouse	NNS
cord-261028-sxux2ujo	341	17	.	.	.
cord-261028-sxux2ujo	342	1	CDN	CDN	NNP
cord-261028-sxux2ujo	342	2	based	base	VBN
cord-261028-sxux2ujo	342	3	STING	sting	NN
cord-261028-sxux2ujo	342	4	agonists	agonist	NNS
cord-261028-sxux2ujo	342	5	have	have	VBP
cord-261028-sxux2ujo	342	6	also	also	RB
cord-261028-sxux2ujo	342	7	been	be	VBN
cord-261028-sxux2ujo	342	8	used	use	VBN
cord-261028-sxux2ujo	342	9	in	in	IN
cord-261028-sxux2ujo	342	10	conjunction	conjunction	NN
cord-261028-sxux2ujo	342	11	with	with	IN
cord-261028-sxux2ujo	342	12	the	the	DT
cord-261028-sxux2ujo	342	13	GVACs	GVACs	NNP
cord-261028-sxux2ujo	342	14	cancer	cancer	NN
cord-261028-sxux2ujo	342	15	vaccine	vaccine	NN
cord-261028-sxux2ujo	342	16	along	along	IN
cord-261028-sxux2ujo	342	17	with	with	IN
cord-261028-sxux2ujo	342	18	a	a	DT
cord-261028-sxux2ujo	342	19	PD1	PD1	NNP
cord-261028-sxux2ujo	342	20	antagonist	antagonist	NN
cord-261028-sxux2ujo	342	21	,	,	,
cord-261028-sxux2ujo	342	22	which	which	WDT
cord-261028-sxux2ujo	342	23	resulted	result	VBD
cord-261028-sxux2ujo	342	24	in	in	IN
cord-261028-sxux2ujo	342	25	an	an	DT
cord-261028-sxux2ujo	342	26	additive	additive	NN
cord-261028-sxux2ujo	342	27	effect	effect	NN
cord-261028-sxux2ujo	342	28	on	on	IN
cord-261028-sxux2ujo	342	29	tumor	tumor	NN
cord-261028-sxux2ujo	342	30	immunity	immunity	NN
cord-261028-sxux2ujo	342	31	(	(	-LRB-
cord-261028-sxux2ujo	342	32	Fu	Fu	NNP
cord-261028-sxux2ujo	342	33	et	et	FW
cord-261028-sxux2ujo	342	34	al	al	NNP
cord-261028-sxux2ujo	342	35	.	.	NNP
cord-261028-sxux2ujo	342	36	,	,	,
cord-261028-sxux2ujo	342	37	2015	2015	CD
cord-261028-sxux2ujo	342	38	)	)	-RRB-
cord-261028-sxux2ujo	342	39	.	.	.
cord-261028-sxux2ujo	343	1	This	this	DT
cord-261028-sxux2ujo	343	2	opens	open	VBZ
cord-261028-sxux2ujo	343	3	new	new	JJ
cord-261028-sxux2ujo	343	4	avenues	avenue	NNS
cord-261028-sxux2ujo	343	5	for	for	IN
cord-261028-sxux2ujo	343	6	additional	additional	JJ
cord-261028-sxux2ujo	343	7	novel	novel	JJ
cord-261028-sxux2ujo	343	8	therapies	therapy	NNS
cord-261028-sxux2ujo	343	9	including	include	VBG
cord-261028-sxux2ujo	343	10	CD47	CD47	NNP
cord-261028-sxux2ujo	343	11	(	(	-LRB-
cord-261028-sxux2ujo	343	12	"	"	``
cord-261028-sxux2ujo	343	13	do	do	VBP
cord-261028-sxux2ujo	343	14	n't	not	RB
cord-261028-sxux2ujo	343	15	eat	eat	VB
cord-261028-sxux2ujo	343	16	me	-PRON-	PRP
cord-261028-sxux2ujo	343	17	"	"	``
cord-261028-sxux2ujo	343	18	signal	signal	NN
cord-261028-sxux2ujo	343	19	)	)	-RRB-
cord-261028-sxux2ujo	343	20	blockade	blockade	NN
cord-261028-sxux2ujo	343	21	which	which	WDT
cord-261028-sxux2ujo	343	22	has	have	VBZ
cord-261028-sxux2ujo	343	23	been	be	VBN
cord-261028-sxux2ujo	343	24	shown	show	VBN
cord-261028-sxux2ujo	343	25	to	to	TO
cord-261028-sxux2ujo	343	26	be	be	VB
cord-261028-sxux2ujo	343	27	critically	critically	RB
cord-261028-sxux2ujo	343	28	dependent	dependent	JJ
cord-261028-sxux2ujo	343	29	on	on	IN
cord-261028-sxux2ujo	343	30	the	the	DT
cord-261028-sxux2ujo	343	31	IFN	IFN	NNP
cord-261028-sxux2ujo	343	32	/	/	SYM
cord-261028-sxux2ujo	343	33	STING	STING	NNP
cord-261028-sxux2ujo	343	34	pathway	pathway	NN
cord-261028-sxux2ujo	343	35	(	(	-LRB-
cord-261028-sxux2ujo	343	36	Liu	Liu	NNP
cord-261028-sxux2ujo	343	37	et	et	NNP
cord-261028-sxux2ujo	343	38	al	al	NNP
cord-261028-sxux2ujo	343	39	.	.	NNP
cord-261028-sxux2ujo	343	40	,	,	,
cord-261028-sxux2ujo	343	41	2015	2015	CD
cord-261028-sxux2ujo	343	42	)	)	-RRB-
cord-261028-sxux2ujo	343	43	.	.	.
cord-261028-sxux2ujo	344	1	As	as	IN
cord-261028-sxux2ujo	344	2	described	describe	VBN
cord-261028-sxux2ujo	344	3	above	above	RB
cord-261028-sxux2ujo	344	4	,	,	,
cord-261028-sxux2ujo	344	5	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	344	6	induces	induce	VBZ
cord-261028-sxux2ujo	344	7	DNA	dna	NN
cord-261028-sxux2ujo	344	8	damage	damage	NN
cord-261028-sxux2ujo	344	9	that	that	WDT
cord-261028-sxux2ujo	344	10	is	be	VBZ
cord-261028-sxux2ujo	344	11	sensed	sense	VBN
cord-261028-sxux2ujo	344	12	by	by	IN
cord-261028-sxux2ujo	344	13	TIDCs	tidc	NNS
cord-261028-sxux2ujo	344	14	through	through	IN
cord-261028-sxux2ujo	344	15	the	the	DT
cord-261028-sxux2ujo	344	16	STING	sting	NN
cord-261028-sxux2ujo	344	17	pathway	pathway	NN
cord-261028-sxux2ujo	344	18	,	,	,
cord-261028-sxux2ujo	344	19	and	and	CC
cord-261028-sxux2ujo	344	20	there	there	EX
cord-261028-sxux2ujo	344	21	are	be	VBP
cord-261028-sxux2ujo	344	22	currently	currently	RB
cord-261028-sxux2ujo	344	23	many	many	JJ
cord-261028-sxux2ujo	344	24	pre	pre	JJ
cord-261028-sxux2ujo	344	25	-	-	JJ
cord-261028-sxux2ujo	344	26	clinical	clinical	JJ
cord-261028-sxux2ujo	344	27	and	and	CC
cord-261028-sxux2ujo	344	28	several	several	JJ
cord-261028-sxux2ujo	344	29	clinical	clinical	JJ
cord-261028-sxux2ujo	344	30	studies	study	NNS
cord-261028-sxux2ujo	344	31	utilizing	utilize	VBG
cord-261028-sxux2ujo	344	32	radiation	radiation	NN
cord-261028-sxux2ujo	344	33	to	to	TO
cord-261028-sxux2ujo	344	34	stimulate	stimulate	VB
cord-261028-sxux2ujo	344	35	anti	anti	JJ
cord-261028-sxux2ujo	344	36	-	-	JJ
cord-261028-sxux2ujo	344	37	tumor	tumor	JJ
cord-261028-sxux2ujo	344	38	immunity	immunity	NN
cord-261028-sxux2ujo	344	39	.	.	.
cord-261028-sxux2ujo	345	1	Since	since	IN
cord-261028-sxux2ujo	345	2	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	345	3	alone	alone	RB
cord-261028-sxux2ujo	345	4	rarely	rarely	RB
cord-261028-sxux2ujo	345	5	induces	induce	VBZ
cord-261028-sxux2ujo	345	6	an	an	DT
cord-261028-sxux2ujo	345	7	anti	anti	JJ
cord-261028-sxux2ujo	345	8	-	-	JJ
cord-261028-sxux2ujo	345	9	tumor	tumor	JJ
cord-261028-sxux2ujo	345	10	immune	immune	JJ
cord-261028-sxux2ujo	345	11	response	response	NN
cord-261028-sxux2ujo	345	12	that	that	WDT
cord-261028-sxux2ujo	345	13	results	result	VBZ
cord-261028-sxux2ujo	345	14	in	in	IN
cord-261028-sxux2ujo	345	15	systemic	systemic	JJ
cord-261028-sxux2ujo	345	16	control	control	NN
cord-261028-sxux2ujo	345	17	of	of	IN
cord-261028-sxux2ujo	345	18	metastatic	metastatic	JJ
cord-261028-sxux2ujo	345	19	disease	disease	NN
cord-261028-sxux2ujo	345	20	,	,	,
cord-261028-sxux2ujo	345	21	the	the	DT
cord-261028-sxux2ujo	345	22	therapeutic	therapeutic	JJ
cord-261028-sxux2ujo	345	23	effects	effect	NNS
cord-261028-sxux2ujo	345	24	of	of	IN
cord-261028-sxux2ujo	345	25	radiation	radiation	NN
cord-261028-sxux2ujo	345	26	on	on	IN
cord-261028-sxux2ujo	345	27	the	the	DT
cord-261028-sxux2ujo	345	28	innate	innate	JJ
cord-261028-sxux2ujo	345	29	and	and	CC
cord-261028-sxux2ujo	345	30	adaptive	adaptive	JJ
cord-261028-sxux2ujo	345	31	immune	immune	JJ
cord-261028-sxux2ujo	345	32	system	system	NN
cord-261028-sxux2ujo	345	33	have	have	VBP
cord-261028-sxux2ujo	345	34	been	be	VBN
cord-261028-sxux2ujo	345	35	largely	largely	RB
cord-261028-sxux2ujo	345	36	explored	explore	VBN
cord-261028-sxux2ujo	345	37	in	in	IN
cord-261028-sxux2ujo	345	38	combination	combination	NN
cord-261028-sxux2ujo	345	39	with	with	IN
cord-261028-sxux2ujo	345	40	other	other	JJ
cord-261028-sxux2ujo	345	41	immunotherapy	immunotherapy	NN
cord-261028-sxux2ujo	345	42	modalities	modality	NNS
cord-261028-sxux2ujo	345	43	.	.	.
cord-261028-sxux2ujo	346	1	The	the	DT
cord-261028-sxux2ujo	346	2	initial	initial	JJ
cord-261028-sxux2ujo	346	3	studies	study	NNS
cord-261028-sxux2ujo	346	4	demonstrating	demonstrate	VBG
cord-261028-sxux2ujo	346	5	the	the	DT
cord-261028-sxux2ujo	346	6	synergistic	synergistic	JJ
cord-261028-sxux2ujo	346	7	effect	effect	NN
cord-261028-sxux2ujo	346	8	of	of	IN
cord-261028-sxux2ujo	346	9	radiation	radiation	NN
cord-261028-sxux2ujo	346	10	combined	combine	VBN
cord-261028-sxux2ujo	346	11	with	with	IN
cord-261028-sxux2ujo	346	12	immune	immune	JJ
cord-261028-sxux2ujo	346	13	modulators	modulator	NNS
cord-261028-sxux2ujo	346	14	were	be	VBD
cord-261028-sxux2ujo	346	15	performed	perform	VBN
cord-261028-sxux2ujo	346	16	by	by	IN
cord-261028-sxux2ujo	346	17	Demaria	Demaria	NNP
cord-261028-sxux2ujo	346	18	and	and	CC
cord-261028-sxux2ujo	346	19	Formenti	Formenti	NNP
cord-261028-sxux2ujo	346	20	.	.	.
cord-261028-sxux2ujo	347	1	Their	-PRON-	PRP$
cord-261028-sxux2ujo	347	2	group	group	NN
cord-261028-sxux2ujo	347	3	observed	observe	VBD
cord-261028-sxux2ujo	347	4	improved	improved	JJ
cord-261028-sxux2ujo	347	5	tumor	tumor	NN
cord-261028-sxux2ujo	347	6	control	control	NN
cord-261028-sxux2ujo	347	7	within	within	IN
cord-261028-sxux2ujo	347	8	the	the	DT
cord-261028-sxux2ujo	347	9	irradiated	irradiate	VBN
cord-261028-sxux2ujo	347	10	field	field	NN
cord-261028-sxux2ujo	347	11	and	and	CC
cord-261028-sxux2ujo	347	12	objective	objective	JJ
cord-261028-sxux2ujo	347	13	responses	response	NNS
cord-261028-sxux2ujo	347	14	in	in	IN
cord-261028-sxux2ujo	347	15	distant	distant	JJ
cord-261028-sxux2ujo	347	16	sites	site	NNS
cord-261028-sxux2ujo	347	17	of	of	IN
cord-261028-sxux2ujo	347	18	disease	disease	NN
cord-261028-sxux2ujo	347	19	using	use	VBG
cord-261028-sxux2ujo	347	20	FLT3	FLT3	NNP
cord-261028-sxux2ujo	347	21	ligand	ligand	NN
cord-261028-sxux2ujo	347	22	or	or	CC
cord-261028-sxux2ujo	347	23	antibody	antibody	NN
cord-261028-sxux2ujo	347	24	antagonists	antagonist	NNS
cord-261028-sxux2ujo	347	25	to	to	IN
cord-261028-sxux2ujo	347	26	the	the	DT
cord-261028-sxux2ujo	347	27	CTLA-4	CTLA-4	NNP
cord-261028-sxux2ujo	347	28	checkpoint	checkpoint	NN
cord-261028-sxux2ujo	347	29	receptor	receptor	NN
cord-261028-sxux2ujo	347	30	in	in	IN
cord-261028-sxux2ujo	347	31	breast	breast	NN
cord-261028-sxux2ujo	347	32	cancer	cancer	NN
cord-261028-sxux2ujo	347	33	and	and	CC
cord-261028-sxux2ujo	347	34	colon	colon	NN
cord-261028-sxux2ujo	347	35	cancer	cancer	NN
cord-261028-sxux2ujo	347	36	models	model	NNS
cord-261028-sxux2ujo	348	1	(	(	-LRB-
cord-261028-sxux2ujo	348	2	Demaria	Demaria	NNP
cord-261028-sxux2ujo	348	3	et	et	NNP
cord-261028-sxux2ujo	348	4	al	al	NNP
cord-261028-sxux2ujo	348	5	.	.	NNP
cord-261028-sxux2ujo	348	6	,	,	,
cord-261028-sxux2ujo	348	7	2004	2004	CD
cord-261028-sxux2ujo	349	1	;	;	:
cord-261028-sxux2ujo	349	2	Demaria	Demaria	NNP
cord-261028-sxux2ujo	349	3	et	et	NNP
cord-261028-sxux2ujo	349	4	al	al	NNP
cord-261028-sxux2ujo	349	5	.	.	.
cord-261028-sxux2ujo	350	1	,	,	,
cord-261028-sxux2ujo	350	2	2005a	2005a	CD
cord-261028-sxux2ujo	350	3	;	;	:
cord-261028-sxux2ujo	350	4	Dewan	Dewan	NNP
cord-261028-sxux2ujo	350	5	et	et	NNP
cord-261028-sxux2ujo	350	6	al	al	NNP
cord-261028-sxux2ujo	350	7	.	.	.
cord-261028-sxux2ujo	351	1	,	,	,
cord-261028-sxux2ujo	351	2	2009	2009	CD
cord-261028-sxux2ujo	351	3	;	;	:
cord-261028-sxux2ujo	351	4	Demaria	Demaria	NNP
cord-261028-sxux2ujo	351	5	et	et	NNP
cord-261028-sxux2ujo	351	6	al	al	NNP
cord-261028-sxux2ujo	351	7	.	.	.
cord-261028-sxux2ujo	352	1	,	,	,
cord-261028-sxux2ujo	352	2	2005b	2005b	CD
cord-261028-sxux2ujo	352	3	)	)	-RRB-
cord-261028-sxux2ujo	352	4	.	.	.
cord-261028-sxux2ujo	353	1	Similar	similar	JJ
cord-261028-sxux2ujo	353	2	findings	finding	NNS
cord-261028-sxux2ujo	353	3	in	in	IN
cord-261028-sxux2ujo	353	4	other	other	JJ
cord-261028-sxux2ujo	353	5	animal	animal	NN
cord-261028-sxux2ujo	353	6	models	model	NNS
cord-261028-sxux2ujo	353	7	combining	combine	VBG
cord-261028-sxux2ujo	353	8	radiation	radiation	NN
cord-261028-sxux2ujo	353	9	with	with	IN
cord-261028-sxux2ujo	353	10	PD-1	PD-1	NNP
cord-261028-sxux2ujo	353	11	inhibitors	inhibitor	NNS
cord-261028-sxux2ujo	353	12	,	,	,
cord-261028-sxux2ujo	353	13	DC	DC	NNP
cord-261028-sxux2ujo	353	14	vaccines	vaccine	NNS
cord-261028-sxux2ujo	353	15	,	,	,
cord-261028-sxux2ujo	353	16	and	and	CC
cord-261028-sxux2ujo	353	17	other	other	JJ
cord-261028-sxux2ujo	353	18	immune	immune	JJ
cord-261028-sxux2ujo	353	19	modulators	modulator	NNS
cord-261028-sxux2ujo	353	20	have	have	VBP
cord-261028-sxux2ujo	353	21	been	be	VBN
cord-261028-sxux2ujo	353	22	observed	observe	VBN
cord-261028-sxux2ujo	353	23	,	,	,
cord-261028-sxux2ujo	353	24	and	and	CC
cord-261028-sxux2ujo	353	25	further	further	JJ
cord-261028-sxux2ujo	353	26	mechanistic	mechanistic	JJ
cord-261028-sxux2ujo	353	27	studies	study	NNS
cord-261028-sxux2ujo	353	28	have	have	VBP
cord-261028-sxux2ujo	353	29	been	be	VBN
cord-261028-sxux2ujo	353	30	performed	perform	VBN
cord-261028-sxux2ujo	353	31	by	by	IN
cord-261028-sxux2ujo	353	32	multiple	multiple	JJ
cord-261028-sxux2ujo	353	33	groups	group	NNS
cord-261028-sxux2ujo	353	34	(	(	-LRB-
cord-261028-sxux2ujo	353	35	Deng	Deng	NNP
cord-261028-sxux2ujo	353	36	et	et	NNP
cord-261028-sxux2ujo	353	37	al	al	NNP
cord-261028-sxux2ujo	353	38	.	.	NNP
cord-261028-sxux2ujo	353	39	,	,	,
cord-261028-sxux2ujo	353	40	2014b	2014b	CD
cord-261028-sxux2ujo	353	41	;	;	:
cord-261028-sxux2ujo	354	1	Filatenkov	Filatenkov	NNP
cord-261028-sxux2ujo	354	2	et	et	NNP
cord-261028-sxux2ujo	354	3	al	al	NNP
cord-261028-sxux2ujo	354	4	.	.	.
cord-261028-sxux2ujo	355	1	,	,	,
cord-261028-sxux2ujo	355	2	2015	2015	CD
cord-261028-sxux2ujo	355	3	;	;	:
cord-261028-sxux2ujo	355	4	Sharabi	Sharabi	NNP
cord-261028-sxux2ujo	355	5	et	et	NNP
cord-261028-sxux2ujo	355	6	al	al	NNP
cord-261028-sxux2ujo	355	7	.	.	.
cord-261028-sxux2ujo	356	1	,	,	,
cord-261028-sxux2ujo	356	2	2015a	2015a	CD
cord-261028-sxux2ujo	356	3	;	;	:
cord-261028-sxux2ujo	356	4	Sharabi	Sharabi	NNP
cord-261028-sxux2ujo	356	5	et	et	NNP
cord-261028-sxux2ujo	356	6	al	al	NNP
cord-261028-sxux2ujo	356	7	.	.	.
cord-261028-sxux2ujo	357	1	,	,	,
cord-261028-sxux2ujo	357	2	2015b	2015b	CD
cord-261028-sxux2ujo	357	3	;	;	:
cord-261028-sxux2ujo	357	4	Vatner	Vatner	NNP
cord-261028-sxux2ujo	357	5	et	et	NNP
cord-261028-sxux2ujo	357	6	al	al	NNP
cord-261028-sxux2ujo	357	7	.	.	NNP
cord-261028-sxux2ujo	357	8	,	,	,
cord-261028-sxux2ujo	357	9	2014	2014	CD
cord-261028-sxux2ujo	357	10	;	;	:
cord-261028-sxux2ujo	357	11	Yoshimoto	Yoshimoto	NNP
cord-261028-sxux2ujo	357	12	et	et	NNP
cord-261028-sxux2ujo	357	13	al	al	NNP
cord-261028-sxux2ujo	357	14	.	.	.
cord-261028-sxux2ujo	358	1	,	,	,
cord-261028-sxux2ujo	358	2	2014	2014	CD
cord-261028-sxux2ujo	358	3	)	)	-RRB-
cord-261028-sxux2ujo	358	4	.	.	.
cord-261028-sxux2ujo	359	1	One	one	CD
cord-261028-sxux2ujo	359	2	study	study	NN
cord-261028-sxux2ujo	359	3	even	even	RB
cord-261028-sxux2ujo	359	4	combined	combine	VBD
cord-261028-sxux2ujo	359	5	radiation	radiation	NN
cord-261028-sxux2ujo	359	6	therapy	therapy	NN
cord-261028-sxux2ujo	359	7	with	with	IN
cord-261028-sxux2ujo	359	8	a	a	DT
cord-261028-sxux2ujo	359	9	pharmacological	pharmacological	JJ
cord-261028-sxux2ujo	359	10	STING	sting	NN
cord-261028-sxux2ujo	359	11	agonist	agonist	NN
cord-261028-sxux2ujo	359	12	and	and	CC
cord-261028-sxux2ujo	359	13	found	find	VBD
cord-261028-sxux2ujo	359	14	improved	improved	JJ
cord-261028-sxux2ujo	359	15	tumor	tumor	NN
cord-261028-sxux2ujo	359	16	control	control	NN
cord-261028-sxux2ujo	359	17	and	and	CC
cord-261028-sxux2ujo	359	18	anti	anti	JJ
cord-261028-sxux2ujo	359	19	-	-	JJ
cord-261028-sxux2ujo	359	20	tumor	tumor	JJ
cord-261028-sxux2ujo	359	21	immunity	immunity	NN
cord-261028-sxux2ujo	359	22	,	,	,
cord-261028-sxux2ujo	359	23	suggesting	suggest	VBG
cord-261028-sxux2ujo	359	24	that	that	IN
cord-261028-sxux2ujo	359	25	radiation	radiation	NN
cord-261028-sxux2ujo	359	26	is	be	VBZ
cord-261028-sxux2ujo	359	27	providing	provide	VBG
cord-261028-sxux2ujo	359	28	a	a	DT
cord-261028-sxux2ujo	359	29	unique	unique	JJ
cord-261028-sxux2ujo	359	30	ingredient	ingredient	NN
cord-261028-sxux2ujo	359	31	to	to	IN
cord-261028-sxux2ujo	359	32	the	the	DT
cord-261028-sxux2ujo	359	33	production	production	NN
cord-261028-sxux2ujo	359	34	of	of	IN
cord-261028-sxux2ujo	359	35	anti	anti	JJ
cord-261028-sxux2ujo	359	36	-	-	JJ
cord-261028-sxux2ujo	359	37	tumor	tumor	JJ
cord-261028-sxux2ujo	359	38	immunity	immunity	NN
cord-261028-sxux2ujo	359	39	above	above	IN
cord-261028-sxux2ujo	359	40	and	and	CC
cord-261028-sxux2ujo	359	41	beyond	beyond	IN
cord-261028-sxux2ujo	359	42	STING	sting	NN
cord-261028-sxux2ujo	359	43	activation	activation	NN
cord-261028-sxux2ujo	360	1	(	(	-LRB-
cord-261028-sxux2ujo	360	2	Baird	Baird	NNP
cord-261028-sxux2ujo	360	3	et	et	NNP
cord-261028-sxux2ujo	360	4	al	al	NNP
cord-261028-sxux2ujo	360	5	.	.	NNP
cord-261028-sxux2ujo	360	6	,	,	,
cord-261028-sxux2ujo	360	7	2016	2016	CD
cord-261028-sxux2ujo	360	8	)	)	-RRB-
cord-261028-sxux2ujo	360	9	.	.	.
cord-261028-sxux2ujo	361	1	These	these	DT
cord-261028-sxux2ujo	361	2	animal	animal	NN
cord-261028-sxux2ujo	361	3	studies	study	NNS
cord-261028-sxux2ujo	361	4	have	have	VBP
cord-261028-sxux2ujo	361	5	been	be	VBN
cord-261028-sxux2ujo	361	6	translated	translate	VBN
cord-261028-sxux2ujo	361	7	successfully	successfully	RB
cord-261028-sxux2ujo	361	8	into	into	IN
cord-261028-sxux2ujo	361	9	preliminary	preliminary	JJ
cord-261028-sxux2ujo	361	10	clinical	clinical	JJ
cord-261028-sxux2ujo	361	11	trials	trial	NNS
cord-261028-sxux2ujo	361	12	of	of	IN
cord-261028-sxux2ujo	361	13	patients	patient	NNS
cord-261028-sxux2ujo	361	14	with	with	IN
cord-261028-sxux2ujo	361	15	metastatic	metastatic	JJ
cord-261028-sxux2ujo	361	16	cancer	cancer	NN
cord-261028-sxux2ujo	361	17	,	,	,
cord-261028-sxux2ujo	361	18	and	and	CC
cord-261028-sxux2ujo	361	19	there	there	EX
cord-261028-sxux2ujo	361	20	are	be	VBP
cord-261028-sxux2ujo	361	21	many	many	JJ
cord-261028-sxux2ujo	361	22	ongoing	ongoing	JJ
cord-261028-sxux2ujo	361	23	trials	trial	NNS
cord-261028-sxux2ujo	361	24	testing	test	VBG
cord-261028-sxux2ujo	361	25	this	this	DT
cord-261028-sxux2ujo	361	26	in	in	IN
cord-261028-sxux2ujo	361	27	patients	patient	NNS
cord-261028-sxux2ujo	361	28	with	with	IN
cord-261028-sxux2ujo	361	29	a	a	DT
cord-261028-sxux2ujo	361	30	variety	variety	NN
cord-261028-sxux2ujo	361	31	of	of	IN
cord-261028-sxux2ujo	361	32	malignancies	malignancy	NNS
cord-261028-sxux2ujo	361	33	.	.	.
cord-261028-sxux2ujo	362	1	Most	Most	JJS
cord-261028-sxux2ujo	362	2	of	of	IN
cord-261028-sxux2ujo	362	3	these	these	DT
cord-261028-sxux2ujo	362	4	trials	trial	NNS
cord-261028-sxux2ujo	362	5	combine	combine	VBP
cord-261028-sxux2ujo	362	6	radiation	radiation	NN
cord-261028-sxux2ujo	362	7	with	with	IN
cord-261028-sxux2ujo	362	8	an	an	DT
cord-261028-sxux2ujo	362	9	immune	immune	JJ
cord-261028-sxux2ujo	362	10	checkpoint	checkpoint	NN
cord-261028-sxux2ujo	362	11	inhibitor	inhibitor	NN
cord-261028-sxux2ujo	362	12	of	of	IN
cord-261028-sxux2ujo	362	13	CTLA-4	CTLA-4	NNPS
cord-261028-sxux2ujo	362	14	or	or	CC
cord-261028-sxux2ujo	362	15	PD-1	PD-1	NNP
cord-261028-sxux2ujo	362	16	with	with	IN
cord-261028-sxux2ujo	362	17	the	the	DT
cord-261028-sxux2ujo	362	18	goal	goal	NN
cord-261028-sxux2ujo	362	19	of	of	IN
cord-261028-sxux2ujo	362	20	priming	prime	VBG
cord-261028-sxux2ujo	362	21	tumor	tumor	NN
cord-261028-sxux2ujo	362	22	specific	specific	JJ
cord-261028-sxux2ujo	362	23	T	t	NN
cord-261028-sxux2ujo	362	24	cells	cell	NNS
cord-261028-sxux2ujo	362	25	with	with	IN
cord-261028-sxux2ujo	362	26	radiation	radiation	NN
cord-261028-sxux2ujo	362	27	,	,	,
cord-261028-sxux2ujo	362	28	and	and	CC
cord-261028-sxux2ujo	362	29	boosting	boost	VBG
cord-261028-sxux2ujo	362	30	that	that	DT
cord-261028-sxux2ujo	362	31	T	T	NNP
cord-261028-sxux2ujo	362	32	cell	cell	NN
cord-261028-sxux2ujo	362	33	response	response	NN
cord-261028-sxux2ujo	362	34	with	with	IN
cord-261028-sxux2ujo	362	35	the	the	DT
cord-261028-sxux2ujo	362	36	checkpoint	checkpoint	NN
cord-261028-sxux2ujo	362	37	inhibitors	inhibitor	NNS
cord-261028-sxux2ujo	362	38	to	to	TO
cord-261028-sxux2ujo	362	39	overcome	overcome	VB
cord-261028-sxux2ujo	362	40	the	the	DT
cord-261028-sxux2ujo	362	41	suppressive	suppressive	JJ
cord-261028-sxux2ujo	362	42	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	362	43	.	.	.
cord-261028-sxux2ujo	363	1	Preliminary	preliminary	JJ
cord-261028-sxux2ujo	363	2	results	result	NNS
cord-261028-sxux2ujo	363	3	appear	appear	VBP
cord-261028-sxux2ujo	363	4	promising	promising	JJ
cord-261028-sxux2ujo	363	5	,	,	,
cord-261028-sxux2ujo	363	6	but	but	CC
cord-261028-sxux2ujo	363	7	mature	mature	JJ
cord-261028-sxux2ujo	363	8	results	result	NNS
cord-261028-sxux2ujo	363	9	from	from	IN
cord-261028-sxux2ujo	363	10	these	these	DT
cord-261028-sxux2ujo	363	11	trials	trial	NNS
cord-261028-sxux2ujo	363	12	are	be	VBP
cord-261028-sxux2ujo	363	13	pending	pende	VBG
cord-261028-sxux2ujo	363	14	(	(	-LRB-
cord-261028-sxux2ujo	363	15	Golden	Golden	NNP
cord-261028-sxux2ujo	363	16	et	et	FW
cord-261028-sxux2ujo	363	17	al	al	NNP
cord-261028-sxux2ujo	363	18	.	.	NNP
cord-261028-sxux2ujo	363	19	,	,	,
cord-261028-sxux2ujo	363	20	2015	2015	CD
cord-261028-sxux2ujo	363	21	)	)	-RRB-
cord-261028-sxux2ujo	363	22	.	.	.
cord-261028-sxux2ujo	364	1	With	with	IN
cord-261028-sxux2ujo	364	2	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	364	3	there	there	EX
cord-261028-sxux2ujo	364	4	are	be	VBP
cord-261028-sxux2ujo	364	5	always	always	RB
cord-261028-sxux2ujo	364	6	questions	question	NNS
cord-261028-sxux2ujo	364	7	about	about	IN
cord-261028-sxux2ujo	364	8	the	the	DT
cord-261028-sxux2ujo	364	9	optimal	optimal	JJ
cord-261028-sxux2ujo	364	10	dose	dose	NN
cord-261028-sxux2ujo	364	11	to	to	TO
cord-261028-sxux2ujo	364	12	use	use	VB
cord-261028-sxux2ujo	364	13	and	and	CC
cord-261028-sxux2ujo	364	14	how	how	WRB
cord-261028-sxux2ujo	364	15	many	many	JJ
cord-261028-sxux2ujo	364	16	treatments	treatment	NNS
cord-261028-sxux2ujo	364	17	to	to	TO
cord-261028-sxux2ujo	364	18	deliver	deliver	VB
cord-261028-sxux2ujo	364	19	(	(	-LRB-
cord-261028-sxux2ujo	364	20	fractionation	fractionation	NN
cord-261028-sxux2ujo	364	21	)	)	-RRB-
cord-261028-sxux2ujo	364	22	for	for	IN
cord-261028-sxux2ujo	364	23	activating	activate	VBG
cord-261028-sxux2ujo	364	24	STING	sting	NN
cord-261028-sxux2ujo	364	25	and	and	CC
cord-261028-sxux2ujo	364	26	initiating	initiate	VBG
cord-261028-sxux2ujo	364	27	an	an	DT
cord-261028-sxux2ujo	364	28	immune	immune	JJ
cord-261028-sxux2ujo	364	29	response	response	NN
cord-261028-sxux2ujo	364	30	.	.	.
cord-261028-sxux2ujo	365	1	This	this	DT
cord-261028-sxux2ujo	365	2	is	be	VBZ
cord-261028-sxux2ujo	365	3	an	an	DT
cord-261028-sxux2ujo	365	4	active	active	JJ
cord-261028-sxux2ujo	365	5	question	question	NN
cord-261028-sxux2ujo	365	6	in	in	IN
cord-261028-sxux2ujo	365	7	the	the	DT
cord-261028-sxux2ujo	365	8	field	field	NN
cord-261028-sxux2ujo	365	9	,	,	,
cord-261028-sxux2ujo	365	10	however	however	RB
cord-261028-sxux2ujo	365	11	there	there	EX
cord-261028-sxux2ujo	365	12	are	be	VBP
cord-261028-sxux2ujo	365	13	few	few	JJ
cord-261028-sxux2ujo	365	14	preclinical	preclinical	JJ
cord-261028-sxux2ujo	365	15	studies	study	NNS
cord-261028-sxux2ujo	365	16	and	and	CC
cord-261028-sxux2ujo	365	17	even	even	RB
cord-261028-sxux2ujo	365	18	fewer	few	JJR
cord-261028-sxux2ujo	365	19	clinical	clinical	JJ
cord-261028-sxux2ujo	365	20	trials	trial	NNS
cord-261028-sxux2ujo	365	21	comparing	compare	VBG
cord-261028-sxux2ujo	365	22	different	different	JJ
cord-261028-sxux2ujo	365	23	doses	dose	NNS
cord-261028-sxux2ujo	365	24	and	and	CC
cord-261028-sxux2ujo	365	25	fractionation	fractionation	NN
cord-261028-sxux2ujo	365	26	treatment	treatment	NN
cord-261028-sxux2ujo	365	27	schedules	schedule	NNS
cord-261028-sxux2ujo	365	28	.	.	.
cord-261028-sxux2ujo	366	1	Some	some	DT
cord-261028-sxux2ujo	366	2	of	of	IN
cord-261028-sxux2ujo	366	3	the	the	DT
cord-261028-sxux2ujo	366	4	original	original	JJ
cord-261028-sxux2ujo	366	5	studies	study	NNS
cord-261028-sxux2ujo	366	6	by	by	IN
cord-261028-sxux2ujo	366	7	the	the	DT
cord-261028-sxux2ujo	366	8	Demaria	Demaria	NNP
cord-261028-sxux2ujo	366	9	group	group	NN
cord-261028-sxux2ujo	366	10	explored	explore	VBD
cord-261028-sxux2ujo	366	11	dose	dose	NN
cord-261028-sxux2ujo	366	12	and	and	CC
cord-261028-sxux2ujo	366	13	fractionation	fractionation	NN
cord-261028-sxux2ujo	366	14	,	,	,
cord-261028-sxux2ujo	366	15	finding	find	VBG
cord-261028-sxux2ujo	366	16	that	that	IN
cord-261028-sxux2ujo	366	17	24	24	CD
cord-261028-sxux2ujo	366	18	Gy	Gy	NNP
cord-261028-sxux2ujo	366	19	delivered	deliver	VBD
cord-261028-sxux2ujo	366	20	in	in	IN
cord-261028-sxux2ujo	366	21	three	three	CD
cord-261028-sxux2ujo	366	22	fractions	fraction	NNS
cord-261028-sxux2ujo	366	23	of	of	IN
cord-261028-sxux2ujo	366	24	8	8	CD
cord-261028-sxux2ujo	366	25	Gy	Gy	NNP
cord-261028-sxux2ujo	366	26	resulted	result	VBD
cord-261028-sxux2ujo	366	27	in	in	IN
cord-261028-sxux2ujo	366	28	more	more	RBR
cord-261028-sxux2ujo	366	29	robust	robust	JJ
cord-261028-sxux2ujo	366	30	systemic	systemic	JJ
cord-261028-sxux2ujo	366	31	tumor	tumor	NN
cord-261028-sxux2ujo	366	32	control	control	NN
cord-261028-sxux2ujo	366	33	compared	compare	VBN
cord-261028-sxux2ujo	366	34	with	with	IN
cord-261028-sxux2ujo	366	35	30	30	CD
cord-261028-sxux2ujo	366	36	Gy	Gy	NNP
cord-261028-sxux2ujo	366	37	in	in	IN
cord-261028-sxux2ujo	366	38	five	five	CD
cord-261028-sxux2ujo	366	39	fractions	fraction	NNS
cord-261028-sxux2ujo	366	40	or	or	CC
cord-261028-sxux2ujo	366	41	a	a	DT
cord-261028-sxux2ujo	366	42	single	single	JJ
cord-261028-sxux2ujo	366	43	fraction	fraction	NN
cord-261028-sxux2ujo	366	44	of	of	IN
cord-261028-sxux2ujo	366	45	20	20	CD
cord-261028-sxux2ujo	366	46	Gy	Gy	NNP
cord-261028-sxux2ujo	366	47	(	(	-LRB-
cord-261028-sxux2ujo	366	48	Dewan	Dewan	NNP
cord-261028-sxux2ujo	366	49	et	et	NNP
cord-261028-sxux2ujo	366	50	al	al	NNP
cord-261028-sxux2ujo	366	51	.	.	NNP
cord-261028-sxux2ujo	366	52	,	,	,
cord-261028-sxux2ujo	366	53	2009	2009	CD
cord-261028-sxux2ujo	366	54	)	)	-RRB-
cord-261028-sxux2ujo	366	55	.	.	.
cord-261028-sxux2ujo	367	1	A	a	DT
cord-261028-sxux2ujo	367	2	recent	recent	JJ
cord-261028-sxux2ujo	367	3	study	study	NN
cord-261028-sxux2ujo	367	4	by	by	IN
cord-261028-sxux2ujo	367	5	this	this	DT
cord-261028-sxux2ujo	367	6	group	group	NN
cord-261028-sxux2ujo	367	7	explored	explore	VBD
cord-261028-sxux2ujo	367	8	the	the	DT
cord-261028-sxux2ujo	367	9	mechanistic	mechanistic	JJ
cord-261028-sxux2ujo	367	10	underpinnings	underpinning	NNS
cord-261028-sxux2ujo	367	11	of	of	IN
cord-261028-sxux2ujo	367	12	why	why	WRB
cord-261028-sxux2ujo	367	13	a	a	DT
cord-261028-sxux2ujo	367	14	single	single	JJ
cord-261028-sxux2ujo	367	15	larger	large	JJR
cord-261028-sxux2ujo	367	16	fraction	fraction	NN
cord-261028-sxux2ujo	367	17	of	of	IN
cord-261028-sxux2ujo	367	18	20	20	CD
cord-261028-sxux2ujo	367	19	Gy	Gy	NNS
cord-261028-sxux2ujo	367	20	of	of	IN
cord-261028-sxux2ujo	367	21	radiation	radiation	NN
cord-261028-sxux2ujo	367	22	is	be	VBZ
cord-261028-sxux2ujo	367	23	not	not	RB
cord-261028-sxux2ujo	367	24	as	as	RB
cord-261028-sxux2ujo	367	25	effective	effective	JJ
cord-261028-sxux2ujo	367	26	as	as	IN
cord-261028-sxux2ujo	367	27	three	three	CD
cord-261028-sxux2ujo	367	28	fractions	fraction	NNS
cord-261028-sxux2ujo	367	29	of	of	IN
cord-261028-sxux2ujo	367	30	8	8	CD
cord-261028-sxux2ujo	367	31	Gy	Gy	NNP
cord-261028-sxux2ujo	367	32	,	,	,
cord-261028-sxux2ujo	367	33	and	and	CC
cord-261028-sxux2ujo	367	34	found	find	VBD
cord-261028-sxux2ujo	367	35	that	that	IN
cord-261028-sxux2ujo	367	36	both	both	DT
cord-261028-sxux2ujo	367	37	treatments	treatment	NNS
cord-261028-sxux2ujo	367	38	resulted	result	VBD
cord-261028-sxux2ujo	367	39	in	in	IN
cord-261028-sxux2ujo	367	40	transport	transport	NN
cord-261028-sxux2ujo	367	41	of	of	IN
cord-261028-sxux2ujo	367	42	dsDNA	dsdna	NN
cord-261028-sxux2ujo	367	43	to	to	IN
cord-261028-sxux2ujo	367	44	the	the	DT
cord-261028-sxux2ujo	367	45	cytosol	cytosol	NN
cord-261028-sxux2ujo	367	46	of	of	IN
cord-261028-sxux2ujo	367	47	tumor	tumor	NN
cord-261028-sxux2ujo	367	48	cells	cell	NNS
cord-261028-sxux2ujo	367	49	where	where	WRB
cord-261028-sxux2ujo	367	50	it	-PRON-	PRP
cord-261028-sxux2ujo	367	51	was	be	VBD
cord-261028-sxux2ujo	367	52	sensed	sense	VBN
cord-261028-sxux2ujo	367	53	by	by	IN
cord-261028-sxux2ujo	367	54	cGAS	cGAS	NNP
cord-261028-sxux2ujo	367	55	,	,	,
cord-261028-sxux2ujo	367	56	which	which	WDT
cord-261028-sxux2ujo	367	57	activated	activate	VBD
cord-261028-sxux2ujo	367	58	STING	sting	NN
cord-261028-sxux2ujo	367	59	and	and	CC
cord-261028-sxux2ujo	367	60	type	type	NN
cord-261028-sxux2ujo	368	1	I	-PRON-	PRP
cord-261028-sxux2ujo	368	2	IFN	IFN	NNP
cord-261028-sxux2ujo	368	3	transcription	transcription	NN
cord-261028-sxux2ujo	369	1	(	(	-LRB-
cord-261028-sxux2ujo	369	2	Vanpouille	Vanpouille	NNP
cord-261028-sxux2ujo	369	3	-	-	HYPH
cord-261028-sxux2ujo	369	4	Box	Box	NNP
cord-261028-sxux2ujo	369	5	et	et	NNP
cord-261028-sxux2ujo	369	6	al	al	NNP
cord-261028-sxux2ujo	369	7	.	.	NNP
cord-261028-sxux2ujo	369	8	,	,	,
cord-261028-sxux2ujo	369	9	2017	2017	CD
cord-261028-sxux2ujo	369	10	)	)	-RRB-
cord-261028-sxux2ujo	369	11	.	.	.
cord-261028-sxux2ujo	370	1	However	however	RB
cord-261028-sxux2ujo	370	2	,	,	,
cord-261028-sxux2ujo	370	3	the	the	DT
cord-261028-sxux2ujo	370	4	larger	large	JJR
cord-261028-sxux2ujo	370	5	dose	dose	NN
cord-261028-sxux2ujo	370	6	of	of	IN
cord-261028-sxux2ujo	370	7	radiation	radiation	NN
cord-261028-sxux2ujo	370	8	induced	induce	VBN
cord-261028-sxux2ujo	371	1	the	the	DT
cord-261028-sxux2ujo	371	2	three	three	CD
cord-261028-sxux2ujo	371	3	prime	prime	JJ
cord-261028-sxux2ujo	371	4	exonuclease	exonuclease	NN
cord-261028-sxux2ujo	371	5	1	1	CD
cord-261028-sxux2ujo	371	6	(	(	-LRB-
cord-261028-sxux2ujo	371	7	TREX1	TREX1	NNP
cord-261028-sxux2ujo	371	8	)	)	-RRB-
cord-261028-sxux2ujo	371	9	,	,	,
cord-261028-sxux2ujo	371	10	which	which	WDT
cord-261028-sxux2ujo	371	11	degraded	degrade	VBD
cord-261028-sxux2ujo	371	12	the	the	DT
cord-261028-sxux2ujo	371	13	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	371	14	DNA	dna	NN
cord-261028-sxux2ujo	371	15	,	,	,
cord-261028-sxux2ujo	371	16	limiting	limit	VBG
cord-261028-sxux2ujo	371	17	STING	sting	NN
cord-261028-sxux2ujo	371	18	activation	activation	NN
cord-261028-sxux2ujo	371	19	and	and	CC
cord-261028-sxux2ujo	371	20	the	the	DT
cord-261028-sxux2ujo	371	21	IFN	IFN	NNP
cord-261028-sxux2ujo	371	22	response	response	NN
cord-261028-sxux2ujo	371	23	.	.	.
cord-261028-sxux2ujo	372	1	Studies	study	NNS
cord-261028-sxux2ujo	372	2	by	by	IN
cord-261028-sxux2ujo	372	3	other	other	JJ
cord-261028-sxux2ujo	372	4	groups	group	NNS
cord-261028-sxux2ujo	372	5	comparing	compare	VBG
cord-261028-sxux2ujo	372	6	single	single	JJ
cord-261028-sxux2ujo	372	7	fraction	fraction	NN
cord-261028-sxux2ujo	372	8	treatment	treatment	NN
cord-261028-sxux2ujo	372	9	with	with	IN
cord-261028-sxux2ujo	372	10	fractionated	fractionate	VBN
cord-261028-sxux2ujo	372	11	treatment	treatment	NN
cord-261028-sxux2ujo	372	12	have	have	VBP
cord-261028-sxux2ujo	372	13	shown	show	VBN
cord-261028-sxux2ujo	372	14	conflicting	conflict	VBG
cord-261028-sxux2ujo	372	15	results	result	NNS
cord-261028-sxux2ujo	372	16	,	,	,
cord-261028-sxux2ujo	372	17	however	however	RB
cord-261028-sxux2ujo	372	18	most	most	JJS
cord-261028-sxux2ujo	372	19	of	of	IN
cord-261028-sxux2ujo	372	20	these	these	DT
cord-261028-sxux2ujo	372	21	utilized	utilize	VBN
cord-261028-sxux2ujo	372	22	single	single	JJ
cord-261028-sxux2ujo	372	23	fraction	fraction	NN
cord-261028-sxux2ujo	372	24	treatment	treatment	NN
cord-261028-sxux2ujo	372	25	doses	dose	NNS
cord-261028-sxux2ujo	372	26	<	<	XX
cord-261028-sxux2ujo	372	27	20	20	CD
cord-261028-sxux2ujo	372	28	Gy	Gy	NNP
cord-261028-sxux2ujo	372	29	,	,	,
cord-261028-sxux2ujo	372	30	the	the	DT
cord-261028-sxux2ujo	372	31	apparent	apparent	JJ
cord-261028-sxux2ujo	372	32	threshold	threshold	NN
cord-261028-sxux2ujo	372	33	for	for	IN
cord-261028-sxux2ujo	372	34	activation	activation	NN
cord-261028-sxux2ujo	372	35	of	of	IN
cord-261028-sxux2ujo	372	36	TREX1	TREX1	NNP
cord-261028-sxux2ujo	372	37	.	.	.
cord-261028-sxux2ujo	373	1	Beyond	beyond	IN
cord-261028-sxux2ujo	373	2	dose	dose	NN
cord-261028-sxux2ujo	373	3	and	and	CC
cord-261028-sxux2ujo	373	4	fractionation	fractionation	NN
cord-261028-sxux2ujo	373	5	,	,	,
cord-261028-sxux2ujo	373	6	there	there	EX
cord-261028-sxux2ujo	373	7	are	be	VBP
cord-261028-sxux2ujo	373	8	other	other	JJ
cord-261028-sxux2ujo	373	9	questions	question	NNS
cord-261028-sxux2ujo	373	10	that	that	WDT
cord-261028-sxux2ujo	373	11	remain	remain	VBP
cord-261028-sxux2ujo	373	12	about	about	IN
cord-261028-sxux2ujo	373	13	the	the	DT
cord-261028-sxux2ujo	373	14	optimal	optimal	JJ
cord-261028-sxux2ujo	373	15	application	application	NN
cord-261028-sxux2ujo	373	16	of	of	IN
cord-261028-sxux2ujo	373	17	radiation	radiation	NN
cord-261028-sxux2ujo	373	18	therapy	therapy	NN
cord-261028-sxux2ujo	373	19	for	for	IN
cord-261028-sxux2ujo	373	20	stimulating	stimulate	VBG
cord-261028-sxux2ujo	373	21	STING	sting	NN
cord-261028-sxux2ujo	373	22	mediated	mediate	VBN
cord-261028-sxux2ujo	373	23	tumor	tumor	NN
cord-261028-sxux2ujo	373	24	immunity	immunity	NN
cord-261028-sxux2ujo	373	25	.	.	.
cord-261028-sxux2ujo	374	1	Some	some	DT
cord-261028-sxux2ujo	374	2	of	of	IN
cord-261028-sxux2ujo	374	3	these	these	DT
cord-261028-sxux2ujo	374	4	questions	question	NNS
cord-261028-sxux2ujo	374	5	include	include	VBP
cord-261028-sxux2ujo	374	6	the	the	DT
cord-261028-sxux2ujo	374	7	importance	importance	NN
cord-261028-sxux2ujo	374	8	of	of	IN
cord-261028-sxux2ujo	374	9	the	the	DT
cord-261028-sxux2ujo	374	10	anatomical	anatomical	JJ
cord-261028-sxux2ujo	374	11	location	location	NN
cord-261028-sxux2ujo	374	12	of	of	IN
cord-261028-sxux2ujo	374	13	the	the	DT
cord-261028-sxux2ujo	374	14	target	target	NN
cord-261028-sxux2ujo	374	15	lesion	lesion	NN
cord-261028-sxux2ujo	374	16	,	,	,
cord-261028-sxux2ujo	374	17	whether	whether	IN
cord-261028-sxux2ujo	374	18	it	-PRON-	PRP
cord-261028-sxux2ujo	374	19	is	be	VBZ
cord-261028-sxux2ujo	374	20	better	well	JJR
cord-261028-sxux2ujo	374	21	to	to	TO
cord-261028-sxux2ujo	374	22	treat	treat	VB
cord-261028-sxux2ujo	374	23	the	the	DT
cord-261028-sxux2ujo	374	24	primary	primary	JJ
cord-261028-sxux2ujo	374	25	tumor	tumor	NN
cord-261028-sxux2ujo	374	26	or	or	CC
cord-261028-sxux2ujo	374	27	metastatic	metastatic	JJ
cord-261028-sxux2ujo	374	28	sites	site	NNS
cord-261028-sxux2ujo	374	29	,	,	,
cord-261028-sxux2ujo	374	30	the	the	DT
cord-261028-sxux2ujo	374	31	effect	effect	NN
cord-261028-sxux2ujo	374	32	of	of	IN
cord-261028-sxux2ujo	374	33	radiation	radiation	NN
cord-261028-sxux2ujo	374	34	dose	dose	NN
cord-261028-sxux2ujo	374	35	rate	rate	NN
cord-261028-sxux2ujo	374	36	,	,	,
cord-261028-sxux2ujo	374	37	and	and	CC
cord-261028-sxux2ujo	374	38	the	the	DT
cord-261028-sxux2ujo	374	39	effect	effect	NN
cord-261028-sxux2ujo	374	40	of	of	IN
cord-261028-sxux2ujo	374	41	different	different	JJ
cord-261028-sxux2ujo	374	42	modalities	modality	NNS
cord-261028-sxux2ujo	374	43	and	and	CC
cord-261028-sxux2ujo	374	44	energies	energy	NNS
cord-261028-sxux2ujo	374	45	of	of	IN
cord-261028-sxux2ujo	374	46	ionizing	ionize	VBG
cord-261028-sxux2ujo	374	47	radiation	radiation	NN
cord-261028-sxux2ujo	374	48	(	(	-LRB-
cord-261028-sxux2ujo	374	49	e.g.	e.g.	IN
cord-261028-sxux2ujo	374	50	photon	photon	NN
cord-261028-sxux2ujo	374	51	vs.	vs.	IN
cord-261028-sxux2ujo	374	52	proton	proton	NN
cord-261028-sxux2ujo	374	53	vs.	vs.	FW
cord-261028-sxux2ujo	374	54	electron	electron	NN
cord-261028-sxux2ujo	374	55	)	)	-RRB-
cord-261028-sxux2ujo	374	56	.	.	.
cord-261028-sxux2ujo	375	1	These	these	DT
cord-261028-sxux2ujo	375	2	questions	question	NNS
cord-261028-sxux2ujo	375	3	remain	remain	VBP
cord-261028-sxux2ujo	375	4	to	to	TO
cord-261028-sxux2ujo	375	5	be	be	VB
cord-261028-sxux2ujo	375	6	worked	work	VBN
cord-261028-sxux2ujo	375	7	out	out	RP
cord-261028-sxux2ujo	375	8	.	.	.
cord-261028-sxux2ujo	376	1	The	the	DT
cord-261028-sxux2ujo	376	2	role	role	NN
cord-261028-sxux2ujo	376	3	of	of	IN
cord-261028-sxux2ujo	376	4	the	the	DT
cord-261028-sxux2ujo	376	5	immune	immune	JJ
cord-261028-sxux2ujo	376	6	system	system	NN
cord-261028-sxux2ujo	376	7	in	in	IN
cord-261028-sxux2ujo	376	8	combatting	combat	VBG
cord-261028-sxux2ujo	376	9	cancer	cancer	NN
cord-261028-sxux2ujo	376	10	has	have	VBZ
cord-261028-sxux2ujo	376	11	been	be	VBN
cord-261028-sxux2ujo	376	12	a	a	DT
cord-261028-sxux2ujo	376	13	topic	topic	NN
cord-261028-sxux2ujo	376	14	of	of	IN
cord-261028-sxux2ujo	376	15	speculation	speculation	NN
cord-261028-sxux2ujo	376	16	and	and	CC
cord-261028-sxux2ujo	376	17	debate	debate	NN
cord-261028-sxux2ujo	376	18	over	over	IN
cord-261028-sxux2ujo	376	19	the	the	DT
cord-261028-sxux2ujo	376	20	past	past	JJ
cord-261028-sxux2ujo	376	21	century	century	NN
cord-261028-sxux2ujo	376	22	,	,	,
cord-261028-sxux2ujo	376	23	with	with	IN
cord-261028-sxux2ujo	376	24	mounting	mount	VBG
cord-261028-sxux2ujo	376	25	experimental	experimental	JJ
cord-261028-sxux2ujo	376	26	evidence	evidence	NN
cord-261028-sxux2ujo	376	27	in	in	IN
cord-261028-sxux2ujo	376	28	support	support	NN
cord-261028-sxux2ujo	376	29	of	of	IN
cord-261028-sxux2ujo	376	30	this	this	DT
cord-261028-sxux2ujo	376	31	function	function	NN
cord-261028-sxux2ujo	376	32	of	of	IN
cord-261028-sxux2ujo	376	33	the	the	DT
cord-261028-sxux2ujo	376	34	immune	immune	JJ
cord-261028-sxux2ujo	376	35	system	system	NN
cord-261028-sxux2ujo	376	36	.	.	.
cord-261028-sxux2ujo	377	1	However	however	RB
cord-261028-sxux2ujo	377	2	,	,	,
cord-261028-sxux2ujo	377	3	it	-PRON-	PRP
cord-261028-sxux2ujo	377	4	was	be	VBD
cord-261028-sxux2ujo	377	5	not	not	RB
cord-261028-sxux2ujo	377	6	until	until	IN
cord-261028-sxux2ujo	377	7	recent	recent	JJ
cord-261028-sxux2ujo	377	8	years	year	NNS
cord-261028-sxux2ujo	377	9	with	with	IN
cord-261028-sxux2ujo	377	10	the	the	DT
cord-261028-sxux2ujo	377	11	success	success	NN
cord-261028-sxux2ujo	377	12	of	of	IN
cord-261028-sxux2ujo	377	13	cancer	cancer	NN
cord-261028-sxux2ujo	377	14	immunotherapy	immunotherapy	NN
cord-261028-sxux2ujo	377	15	applied	apply	VBD
cord-261028-sxux2ujo	377	16	to	to	IN
cord-261028-sxux2ujo	377	17	patient	patient	NN
cord-261028-sxux2ujo	377	18	care	care	NN
cord-261028-sxux2ujo	377	19	that	that	IN
cord-261028-sxux2ujo	377	20	cancer	cancer	NN
cord-261028-sxux2ujo	377	21	immunity	immunity	NN
cord-261028-sxux2ujo	377	22	has	have	VBZ
cord-261028-sxux2ujo	377	23	received	receive	VBN
cord-261028-sxux2ujo	377	24	widespread	widespread	JJ
cord-261028-sxux2ujo	377	25	acceptance	acceptance	NN
cord-261028-sxux2ujo	377	26	.	.	.
cord-261028-sxux2ujo	378	1	How	how	WRB
cord-261028-sxux2ujo	378	2	the	the	DT
cord-261028-sxux2ujo	378	3	immune	immune	JJ
cord-261028-sxux2ujo	378	4	system	system	NN
cord-261028-sxux2ujo	378	5	is	be	VBZ
cord-261028-sxux2ujo	378	6	alerted	alert	VBN
cord-261028-sxux2ujo	378	7	to	to	IN
cord-261028-sxux2ujo	378	8	the	the	DT
cord-261028-sxux2ujo	378	9	presence	presence	NN
cord-261028-sxux2ujo	378	10	of	of	IN
cord-261028-sxux2ujo	378	11	cancer	cancer	NN
cord-261028-sxux2ujo	378	12	has	have	VBZ
cord-261028-sxux2ujo	378	13	been	be	VBN
cord-261028-sxux2ujo	378	14	one	one	CD
cord-261028-sxux2ujo	378	15	of	of	IN
cord-261028-sxux2ujo	378	16	the	the	DT
cord-261028-sxux2ujo	378	17	central	central	JJ
cord-261028-sxux2ujo	378	18	questions	question	NNS
cord-261028-sxux2ujo	378	19	in	in	IN
cord-261028-sxux2ujo	378	20	cancer	cancer	NN
cord-261028-sxux2ujo	378	21	immunology	immunology	NN
cord-261028-sxux2ujo	378	22	.	.	.
cord-261028-sxux2ujo	379	1	DCs	dc	NNS
cord-261028-sxux2ujo	379	2	are	be	VBP
cord-261028-sxux2ujo	379	3	the	the	DT
cord-261028-sxux2ujo	379	4	link	link	NN
cord-261028-sxux2ujo	379	5	between	between	IN
cord-261028-sxux2ujo	379	6	the	the	DT
cord-261028-sxux2ujo	379	7	innate	innate	JJ
cord-261028-sxux2ujo	379	8	and	and	CC
cord-261028-sxux2ujo	379	9	adaptive	adaptive	JJ
cord-261028-sxux2ujo	379	10	immune	immune	JJ
cord-261028-sxux2ujo	379	11	systems	system	NNS
cord-261028-sxux2ujo	379	12	,	,	,
cord-261028-sxux2ujo	379	13	only	only	RB
cord-261028-sxux2ujo	379	14	priming	prime	VBG
cord-261028-sxux2ujo	379	15	T	t	NN
cord-261028-sxux2ujo	379	16	cell	cell	NN
cord-261028-sxux2ujo	379	17	responses	response	NNS
cord-261028-sxux2ujo	379	18	against	against	IN
cord-261028-sxux2ujo	379	19	cellular	cellular	JJ
cord-261028-sxux2ujo	379	20	antigens	antigen	NNS
cord-261028-sxux2ujo	379	21	in	in	IN
cord-261028-sxux2ujo	379	22	the	the	DT
cord-261028-sxux2ujo	379	23	context	context	NN
cord-261028-sxux2ujo	379	24	of	of	IN
cord-261028-sxux2ujo	379	25	an	an	DT
cord-261028-sxux2ujo	379	26	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	379	27	signal	signal	NN
cord-261028-sxux2ujo	379	28	.	.	.
cord-261028-sxux2ujo	380	1	There	there	EX
cord-261028-sxux2ujo	380	2	has	have	VBZ
cord-261028-sxux2ujo	380	3	been	be	VBN
cord-261028-sxux2ujo	380	4	some	some	DT
cord-261028-sxux2ujo	380	5	debate	debate	NN
cord-261028-sxux2ujo	380	6	regarding	regard	VBG
cord-261028-sxux2ujo	380	7	the	the	DT
cord-261028-sxux2ujo	380	8	nature	nature	NN
cord-261028-sxux2ujo	380	9	of	of	IN
cord-261028-sxux2ujo	380	10	this	this	DT
cord-261028-sxux2ujo	380	11	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	380	12	signal	signal	NN
cord-261028-sxux2ujo	380	13	in	in	IN
cord-261028-sxux2ujo	380	14	the	the	DT
cord-261028-sxux2ujo	380	15	response	response	NN
cord-261028-sxux2ujo	380	16	to	to	IN
cord-261028-sxux2ujo	380	17	tumors	tumor	NNS
cord-261028-sxux2ujo	380	18	,	,	,
cord-261028-sxux2ujo	380	19	but	but	CC
cord-261028-sxux2ujo	380	20	recent	recent	JJ
cord-261028-sxux2ujo	380	21	evidence	evidence	NN
cord-261028-sxux2ujo	380	22	summarized	summarize	VBN
cord-261028-sxux2ujo	380	23	in	in	IN
cord-261028-sxux2ujo	380	24	this	this	DT
cord-261028-sxux2ujo	380	25	review	review	NN
cord-261028-sxux2ujo	380	26	support	support	NN
cord-261028-sxux2ujo	380	27	the	the	DT
cord-261028-sxux2ujo	380	28	hypothesis	hypothesis	NN
cord-261028-sxux2ujo	380	29	that	that	IN
cord-261028-sxux2ujo	380	30	damaged	damage	VBD
cord-261028-sxux2ujo	380	31	DNA	DNA	NNP
cord-261028-sxux2ujo	380	32	released	release	VBN
cord-261028-sxux2ujo	380	33	by	by	IN
cord-261028-sxux2ujo	380	34	cancer	cancer	NN
cord-261028-sxux2ujo	380	35	cells	cell	NNS
cord-261028-sxux2ujo	380	36	is	be	VBZ
cord-261028-sxux2ujo	380	37	the	the	DT
cord-261028-sxux2ujo	380	38	stimulus	stimulus	NN
cord-261028-sxux2ujo	380	39	for	for	IN
cord-261028-sxux2ujo	380	40	generating	generate	VBG
cord-261028-sxux2ujo	380	41	tumor	tumor	NN
cord-261028-sxux2ujo	380	42	immunity	immunity	NN
cord-261028-sxux2ujo	380	43	.	.	.
cord-261028-sxux2ujo	381	1	This	this	DT
cord-261028-sxux2ujo	381	2	DNA	dna	NN
cord-261028-sxux2ujo	381	3	gains	gain	VBZ
cord-261028-sxux2ujo	381	4	access	access	NN
cord-261028-sxux2ujo	381	5	to	to	IN
cord-261028-sxux2ujo	381	6	the	the	DT
cord-261028-sxux2ujo	381	7	cytoplasm	cytoplasm	NN
cord-261028-sxux2ujo	381	8	of	of	IN
cord-261028-sxux2ujo	381	9	DCs	dc	NNS
cord-261028-sxux2ujo	381	10	where	where	WRB
cord-261028-sxux2ujo	381	11	it	-PRON-	PRP
cord-261028-sxux2ujo	381	12	is	be	VBZ
cord-261028-sxux2ujo	381	13	recognized	recognize	VBN
cord-261028-sxux2ujo	381	14	by	by	IN
cord-261028-sxux2ujo	381	15	cGAS	cgas	NN
cord-261028-sxux2ujo	381	16	which	which	WDT
cord-261028-sxux2ujo	381	17	triggers	trigger	VBZ
cord-261028-sxux2ujo	381	18	STING	sting	NN
cord-261028-sxux2ujo	381	19	and	and	CC
cord-261028-sxux2ujo	381	20	production	production	NN
cord-261028-sxux2ujo	381	21	of	of	IN
cord-261028-sxux2ujo	381	22	the	the	DT
cord-261028-sxux2ujo	381	23	type	type	NN
cord-261028-sxux2ujo	381	24	I	-PRON-	PRP
cord-261028-sxux2ujo	381	25	IFNs	ifns	VBP
cord-261028-sxux2ujo	381	26	necessary	necessary	JJ
cord-261028-sxux2ujo	381	27	for	for	IN
cord-261028-sxux2ujo	381	28	effective	effective	JJ
cord-261028-sxux2ujo	381	29	crosspriming	crosspriming	NN
cord-261028-sxux2ujo	381	30	of	of	IN
cord-261028-sxux2ujo	381	31	CD8	CD8	NNP
cord-261028-sxux2ujo	381	32	+	+	CC
cord-261028-sxux2ujo	381	33	T	T	NNP
cord-261028-sxux2ujo	381	34	cells	cell	NNS
cord-261028-sxux2ujo	381	35	against	against	IN
cord-261028-sxux2ujo	381	36	tumor	tumor	NN
cord-261028-sxux2ujo	381	37	antigens	antigen	NNS
cord-261028-sxux2ujo	381	38	.	.	.
cord-261028-sxux2ujo	382	1	The	the	DT
cord-261028-sxux2ujo	382	2	primacy	primacy	NN
cord-261028-sxux2ujo	382	3	of	of	IN
cord-261028-sxux2ujo	382	4	DNA	dna	NN
cord-261028-sxux2ujo	382	5	sensing	sensing	NN
cord-261028-sxux2ujo	382	6	as	as	IN
cord-261028-sxux2ujo	382	7	a	a	DT
cord-261028-sxux2ujo	382	8	stimulus	stimulus	NN
cord-261028-sxux2ujo	382	9	for	for	IN
cord-261028-sxux2ujo	382	10	DC	DC	NNP
cord-261028-sxux2ujo	382	11	activation	activation	NN
cord-261028-sxux2ujo	382	12	in	in	IN
cord-261028-sxux2ujo	382	13	response	response	NN
cord-261028-sxux2ujo	382	14	to	to	IN
cord-261028-sxux2ujo	382	15	cancer	cancer	NN
cord-261028-sxux2ujo	382	16	helps	help	VBZ
cord-261028-sxux2ujo	382	17	inform	inform	VB
cord-261028-sxux2ujo	382	18	an	an	DT
cord-261028-sxux2ujo	382	19	ontological	ontological	JJ
cord-261028-sxux2ujo	382	20	question	question	NN
cord-261028-sxux2ujo	382	21	in	in	IN
cord-261028-sxux2ujo	382	22	cancer	cancer	NN
cord-261028-sxux2ujo	382	23	immunology	immunology	NN
cord-261028-sxux2ujo	382	24	.	.	.
cord-261028-sxux2ujo	383	1	Cancer	cancer	NN
cord-261028-sxux2ujo	383	2	has	have	VBZ
cord-261028-sxux2ujo	383	3	historically	historically	RB
cord-261028-sxux2ujo	383	4	been	be	VBN
cord-261028-sxux2ujo	383	5	viewed	view	VBN
cord-261028-sxux2ujo	383	6	as	as	IN
cord-261028-sxux2ujo	383	7	pathogenic	pathogenic	JJ
cord-261028-sxux2ujo	383	8	process	process	NN
cord-261028-sxux2ujo	383	9	separate	separate	JJ
cord-261028-sxux2ujo	383	10	from	from	IN
cord-261028-sxux2ujo	383	11	the	the	DT
cord-261028-sxux2ujo	383	12	host	host	NN
cord-261028-sxux2ujo	383	13	organism	organism	NN
cord-261028-sxux2ujo	383	14	.	.	.
cord-261028-sxux2ujo	384	1	Even	even	RB
cord-261028-sxux2ujo	384	2	the	the	DT
cord-261028-sxux2ujo	384	3	concept	concept	NN
cord-261028-sxux2ujo	384	4	of	of	IN
cord-261028-sxux2ujo	384	5	"	"	``
cord-261028-sxux2ujo	384	6	tumor	tumor	NN
cord-261028-sxux2ujo	384	7	"	"	''
cord-261028-sxux2ujo	384	8	and	and	CC
cord-261028-sxux2ujo	384	9	"	"	``
cord-261028-sxux2ujo	384	10	host	host	NN
cord-261028-sxux2ujo	384	11	"	"	''
cord-261028-sxux2ujo	384	12	suggests	suggest	VBZ
cord-261028-sxux2ujo	384	13	an	an	DT
cord-261028-sxux2ujo	384	14	otherness	otherness	NN
cord-261028-sxux2ujo	384	15	to	to	IN
cord-261028-sxux2ujo	384	16	cancer	cancer	NN
cord-261028-sxux2ujo	384	17	.	.	.
cord-261028-sxux2ujo	385	1	This	this	DT
cord-261028-sxux2ujo	385	2	thinking	thinking	NN
cord-261028-sxux2ujo	385	3	naturally	naturally	RB
cord-261028-sxux2ujo	385	4	led	lead	VBD
cord-261028-sxux2ujo	385	5	to	to	IN
cord-261028-sxux2ujo	385	6	a	a	DT
cord-261028-sxux2ujo	385	7	search	search	NN
cord-261028-sxux2ujo	385	8	for	for	IN
cord-261028-sxux2ujo	385	9	the	the	DT
cord-261028-sxux2ujo	385	10	danger	danger	NN
cord-261028-sxux2ujo	385	11	signals	signal	NNS
cord-261028-sxux2ujo	385	12	produced	produce	VBN
cord-261028-sxux2ujo	385	13	in	in	IN
cord-261028-sxux2ujo	385	14	response	response	NN
cord-261028-sxux2ujo	385	15	to	to	IN
cord-261028-sxux2ujo	385	16	cancer	cancer	NN
cord-261028-sxux2ujo	385	17	,	,	,
cord-261028-sxux2ujo	385	18	and	and	CC
cord-261028-sxux2ujo	385	19	broadened	broaden	VBD
cord-261028-sxux2ujo	385	20	our	-PRON-	PRP$
cord-261028-sxux2ujo	385	21	understanding	understanding	NN
cord-261028-sxux2ujo	385	22	of	of	IN
cord-261028-sxux2ujo	385	23	innate	innate	JJ
cord-261028-sxux2ujo	385	24	immunity	immunity	NN
cord-261028-sxux2ujo	385	25	as	as	IN
cord-261028-sxux2ujo	385	26	a	a	DT
cord-261028-sxux2ujo	385	27	means	means	NN
cord-261028-sxux2ujo	385	28	to	to	TO
cord-261028-sxux2ujo	385	29	detect	detect	VB
cord-261028-sxux2ujo	385	30	self	self	NN
cord-261028-sxux2ujo	385	31	from	from	IN
cord-261028-sxux2ujo	385	32	non	non	JJ
cord-261028-sxux2ujo	385	33	-	-	JJ
cord-261028-sxux2ujo	385	34	self	self	JJ
cord-261028-sxux2ujo	385	35	through	through	IN
cord-261028-sxux2ujo	385	36	PAMPs	pamp	NNS
cord-261028-sxux2ujo	385	37	into	into	IN
cord-261028-sxux2ujo	385	38	a	a	DT
cord-261028-sxux2ujo	385	39	more	more	RBR
cord-261028-sxux2ujo	385	40	generalized	generalized	JJ
cord-261028-sxux2ujo	385	41	view	view	NN
cord-261028-sxux2ujo	385	42	as	as	IN
cord-261028-sxux2ujo	385	43	a	a	DT
cord-261028-sxux2ujo	385	44	means	means	NN
cord-261028-sxux2ujo	385	45	of	of	IN
cord-261028-sxux2ujo	385	46	detecting	detect	VBG
cord-261028-sxux2ujo	385	47	danger	danger	NN
cord-261028-sxux2ujo	385	48	from	from	IN
cord-261028-sxux2ujo	385	49	the	the	DT
cord-261028-sxux2ujo	385	50	absence	absence	NN
cord-261028-sxux2ujo	385	51	of	of	IN
cord-261028-sxux2ujo	385	52	danger	danger	NN
cord-261028-sxux2ujo	385	53	through	through	IN
cord-261028-sxux2ujo	385	54	DAMPs	damp	NNS
cord-261028-sxux2ujo	385	55	.	.	.
cord-261028-sxux2ujo	386	1	The	the	DT
cord-261028-sxux2ujo	386	2	fact	fact	NN
cord-261028-sxux2ujo	386	3	that	that	IN
cord-261028-sxux2ujo	386	4	DCs	dc	NNS
cord-261028-sxux2ujo	386	5	are	be	VBP
cord-261028-sxux2ujo	386	6	sensing	sense	VBG
cord-261028-sxux2ujo	386	7	damaged	damage	VBN
cord-261028-sxux2ujo	386	8	DNA	dna	NN
cord-261028-sxux2ujo	386	9	rather	rather	RB
cord-261028-sxux2ujo	386	10	than	than	IN
cord-261028-sxux2ujo	386	11	a	a	DT
cord-261028-sxux2ujo	386	12	DAMP	damp	NN
cord-261028-sxux2ujo	386	13	associated	associate	VBN
cord-261028-sxux2ujo	386	14	with	with	IN
cord-261028-sxux2ujo	386	15	lytic	lytic	JJ
cord-261028-sxux2ujo	386	16	cell	cell	NN
cord-261028-sxux2ujo	386	17	death	death	NN
cord-261028-sxux2ujo	386	18	places	place	VBZ
cord-261028-sxux2ujo	386	19	the	the	DT
cord-261028-sxux2ujo	386	20	immune	immune	JJ
cord-261028-sxux2ujo	386	21	response	response	NN
cord-261028-sxux2ujo	386	22	to	to	IN
cord-261028-sxux2ujo	386	23	cancer	cancer	NN
cord-261028-sxux2ujo	386	24	more	more	JJR
cord-261028-sxux2ujo	386	25	in	in	IN
cord-261028-sxux2ujo	386	26	the	the	DT
cord-261028-sxux2ujo	386	27	realm	realm	NN
cord-261028-sxux2ujo	386	28	of	of	IN
cord-261028-sxux2ujo	386	29	assaults	assault	NNS
cord-261028-sxux2ujo	386	30	on	on	IN
cord-261028-sxux2ujo	386	31	the	the	DT
cord-261028-sxux2ujo	386	32	integrity	integrity	NN
cord-261028-sxux2ujo	386	33	of	of	IN
cord-261028-sxux2ujo	386	34	the	the	DT
cord-261028-sxux2ujo	386	35	genome	genome	NN
cord-261028-sxux2ujo	386	36	rather	rather	RB
cord-261028-sxux2ujo	386	37	than	than	IN
cord-261028-sxux2ujo	386	38	an	an	DT
cord-261028-sxux2ujo	386	39	exogenous	exogenous	JJ
cord-261028-sxux2ujo	386	40	pathogen	pathogen	NN
cord-261028-sxux2ujo	386	41	.	.	.
cord-261028-sxux2ujo	387	1	Although	although	IN
cord-261028-sxux2ujo	387	2	much	much	JJ
cord-261028-sxux2ujo	387	3	of	of	IN
cord-261028-sxux2ujo	387	4	the	the	DT
cord-261028-sxux2ujo	387	5	mechanism	mechanism	NN
cord-261028-sxux2ujo	387	6	for	for	IN
cord-261028-sxux2ujo	387	7	sensing	sensing	NN
cord-261028-sxux2ujo	387	8	of	of	IN
cord-261028-sxux2ujo	387	9	cancer	cancer	NN
cord-261028-sxux2ujo	387	10	derived	derive	VBN
cord-261028-sxux2ujo	387	11	DNA	dna	NN
cord-261028-sxux2ujo	387	12	via	via	IN
cord-261028-sxux2ujo	387	13	the	the	DT
cord-261028-sxux2ujo	387	14	STING	sting	NN
cord-261028-sxux2ujo	387	15	pathway	pathway	NN
cord-261028-sxux2ujo	387	16	in	in	IN
cord-261028-sxux2ujo	387	17	DCs	DCs	NNP
cord-261028-sxux2ujo	387	18	has	have	VBZ
cord-261028-sxux2ujo	387	19	been	be	VBN
cord-261028-sxux2ujo	387	20	elucidated	elucidate	VBN
cord-261028-sxux2ujo	387	21	,	,	,
cord-261028-sxux2ujo	387	22	many	many	JJ
cord-261028-sxux2ujo	387	23	questions	question	NNS
cord-261028-sxux2ujo	387	24	remain	remain	VBP
cord-261028-sxux2ujo	387	25	.	.	.
cord-261028-sxux2ujo	388	1	One	one	CD
cord-261028-sxux2ujo	388	2	such	such	JJ
cord-261028-sxux2ujo	388	3	question	question	NN
cord-261028-sxux2ujo	388	4	relates	relate	VBZ
cord-261028-sxux2ujo	388	5	to	to	IN
cord-261028-sxux2ujo	388	6	how	how	WRB
cord-261028-sxux2ujo	388	7	tumor	tumor	NN
cord-261028-sxux2ujo	388	8	DNA	dna	NN
cord-261028-sxux2ujo	388	9	taken	take	VBN
cord-261028-sxux2ujo	388	10	up	up	RP
cord-261028-sxux2ujo	388	11	by	by	IN
cord-261028-sxux2ujo	388	12	DCs	DCs	NNP
cord-261028-sxux2ujo	388	13	gains	gain	VBZ
cord-261028-sxux2ujo	388	14	access	access	NN
cord-261028-sxux2ujo	388	15	to	to	IN
cord-261028-sxux2ujo	388	16	the	the	DT
cord-261028-sxux2ujo	388	17	DC	DC	NNP
cord-261028-sxux2ujo	388	18	cytosol	cytosol	NN
cord-261028-sxux2ujo	388	19	.	.	.
cord-261028-sxux2ujo	389	1	It	-PRON-	PRP
cord-261028-sxux2ujo	389	2	may	may	MD
cord-261028-sxux2ujo	389	3	be	be	VB
cord-261028-sxux2ujo	389	4	more	more	JJR
cord-261028-sxux2ujo	389	5	than	than	IN
cord-261028-sxux2ujo	389	6	coincidence	coincidence	NN
cord-261028-sxux2ujo	389	7	that	that	IN
cord-261028-sxux2ujo	389	8	DC	DC	NNP
cord-261028-sxux2ujo	389	9	populations	population	NNS
cord-261028-sxux2ujo	389	10	that	that	WDT
cord-261028-sxux2ujo	389	11	are	be	VBP
cord-261028-sxux2ujo	389	12	efficient	efficient	JJ
cord-261028-sxux2ujo	389	13	in	in	IN
cord-261028-sxux2ujo	389	14	cross	cross	NN
cord-261028-sxux2ujo	389	15	-	-	NN
cord-261028-sxux2ujo	389	16	presentation	presentation	NN
cord-261028-sxux2ujo	389	17	and	and	CC
cord-261028-sxux2ujo	389	18	that	that	DT
cord-261028-sxux2ujo	389	19	exhibit	exhibit	NN
cord-261028-sxux2ujo	389	20	delayed	delay	VBD
cord-261028-sxux2ujo	389	21	endosomal	endosomal	JJ
cord-261028-sxux2ujo	389	22	acidification	acidification	NN
cord-261028-sxux2ujo	389	23	seem	seem	VBP
cord-261028-sxux2ujo	389	24	to	to	TO
cord-261028-sxux2ujo	389	25	be	be	VB
cord-261028-sxux2ujo	389	26	explicitly	explicitly	RB
cord-261028-sxux2ujo	389	27	implicated	implicate	VBN
cord-261028-sxux2ujo	389	28	in	in	IN
cord-261028-sxux2ujo	389	29	the	the	DT
cord-261028-sxux2ujo	389	30	STING	sting	NN
cord-261028-sxux2ujo	389	31	dependent	dependent	JJ
cord-261028-sxux2ujo	389	32	induction	induction	NN
cord-261028-sxux2ujo	389	33	of	of	IN
cord-261028-sxux2ujo	389	34	type	type	NN
cord-261028-sxux2ujo	389	35	I	-PRON-	PRP
cord-261028-sxux2ujo	389	36	IFN	IFN	NNP
cord-261028-sxux2ujo	389	37	.	.	.
cord-261028-sxux2ujo	390	1	One	one	PRP
cord-261028-sxux2ujo	390	2	can	can	MD
cord-261028-sxux2ujo	390	3	envision	envision	VB
cord-261028-sxux2ujo	390	4	a	a	DT
cord-261028-sxux2ujo	390	5	mechanism	mechanism	NN
cord-261028-sxux2ujo	390	6	for	for	IN
cord-261028-sxux2ujo	390	7	DNA	dna	NN
cord-261028-sxux2ujo	390	8	escape	escape	NN
cord-261028-sxux2ujo	390	9	from	from	IN
cord-261028-sxux2ujo	390	10	endosomal	endosomal	NNP
cord-261028-sxux2ujo	390	11	compartments	compartment	NNS
cord-261028-sxux2ujo	390	12	analogous	analogous	JJ
cord-261028-sxux2ujo	390	13	to	to	IN
cord-261028-sxux2ujo	390	14	the	the	DT
cord-261028-sxux2ujo	390	15	manner	manner	NN
cord-261028-sxux2ujo	390	16	by	by	IN
cord-261028-sxux2ujo	390	17	which	which	WDT
cord-261028-sxux2ujo	390	18	endocytosed	endocytose	VBD
cord-261028-sxux2ujo	390	19	proteins	protein	NNS
cord-261028-sxux2ujo	390	20	escape	escape	VBP
cord-261028-sxux2ujo	390	21	into	into	IN
cord-261028-sxux2ujo	390	22	the	the	DT
cord-261028-sxux2ujo	390	23	cytosol	cytosol	NN
cord-261028-sxux2ujo	390	24	where	where	WRB
cord-261028-sxux2ujo	390	25	they	-PRON-	PRP
cord-261028-sxux2ujo	390	26	are	be	VBP
cord-261028-sxux2ujo	390	27	processed	process	VBN
cord-261028-sxux2ujo	390	28	into	into	IN
cord-261028-sxux2ujo	390	29	peptides	peptide	NNS
cord-261028-sxux2ujo	390	30	for	for	IN
cord-261028-sxux2ujo	390	31	presentation	presentation	NN
cord-261028-sxux2ujo	390	32	on	on	IN
cord-261028-sxux2ujo	390	33	MHCI	MHCI	NNP
cord-261028-sxux2ujo	390	34	.	.	.
cord-261028-sxux2ujo	391	1	Another	another	DT
cord-261028-sxux2ujo	391	2	unanswered	unanswered	JJ
cord-261028-sxux2ujo	391	3	question	question	NN
cord-261028-sxux2ujo	391	4	relates	relate	VBZ
cord-261028-sxux2ujo	391	5	to	to	IN
cord-261028-sxux2ujo	391	6	the	the	DT
cord-261028-sxux2ujo	391	7	nature	nature	NN
cord-261028-sxux2ujo	391	8	of	of	IN
cord-261028-sxux2ujo	391	9	the	the	DT
cord-261028-sxux2ujo	391	10	direct	direct	JJ
cord-261028-sxux2ujo	391	11	upstream	upstream	NN
cord-261028-sxux2ujo	391	12	signaling	signal	VBG
cord-261028-sxux2ujo	391	13	molecules	molecule	NNS
cord-261028-sxux2ujo	391	14	that	that	WDT
cord-261028-sxux2ujo	391	15	bind	bind	VBP
cord-261028-sxux2ujo	391	16	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	391	17	DNA	dna	NN
cord-261028-sxux2ujo	391	18	and	and	CC
cord-261028-sxux2ujo	391	19	engage	engage	VB
cord-261028-sxux2ujo	391	20	STING	sting	NN
cord-261028-sxux2ujo	391	21	,	,	,
cord-261028-sxux2ujo	391	22	as	as	IN
cord-261028-sxux2ujo	391	23	these	these	DT
cord-261028-sxux2ujo	391	24	could	could	MD
cord-261028-sxux2ujo	391	25	be	be	VB
cord-261028-sxux2ujo	391	26	targeted	target	VBN
cord-261028-sxux2ujo	391	27	for	for	IN
cord-261028-sxux2ujo	391	28	therapeutic	therapeutic	JJ
cord-261028-sxux2ujo	391	29	benefit	benefit	NN
cord-261028-sxux2ujo	391	30	.	.	.
cord-261028-sxux2ujo	392	1	It	-PRON-	PRP
cord-261028-sxux2ujo	392	2	is	be	VBZ
cord-261028-sxux2ujo	392	3	also	also	RB
cord-261028-sxux2ujo	392	4	intriguing	intriguing	JJ
cord-261028-sxux2ujo	392	5	how	how	WRB
cord-261028-sxux2ujo	392	6	STING	sting	NN
cord-261028-sxux2ujo	392	7	activation	activation	NN
cord-261028-sxux2ujo	392	8	promotes	promote	VBZ
cord-261028-sxux2ujo	392	9	anti	anti	JJ
cord-261028-sxux2ujo	392	10	-	-	JJ
cord-261028-sxux2ujo	392	11	tumor	tumor	JJ
cord-261028-sxux2ujo	392	12	immunity	immunity	NN
cord-261028-sxux2ujo	392	13	in	in	IN
cord-261028-sxux2ujo	392	14	some	some	DT
cord-261028-sxux2ujo	392	15	models	model	NNS
cord-261028-sxux2ujo	392	16	,	,	,
cord-261028-sxux2ujo	392	17	while	while	IN
cord-261028-sxux2ujo	392	18	in	in	IN
cord-261028-sxux2ujo	392	19	others	other	NNS
cord-261028-sxux2ujo	392	20	it	-PRON-	PRP
cord-261028-sxux2ujo	392	21	suppresses	suppress	VBZ
cord-261028-sxux2ujo	392	22	the	the	DT
cord-261028-sxux2ujo	392	23	immune	immune	JJ
cord-261028-sxux2ujo	392	24	response	response	NN
cord-261028-sxux2ujo	392	25	to	to	IN
cord-261028-sxux2ujo	392	26	the	the	DT
cord-261028-sxux2ujo	392	27	tumor	tumor	NN
cord-261028-sxux2ujo	392	28	,	,	,
cord-261028-sxux2ujo	392	29	promoting	promote	VBG
cord-261028-sxux2ujo	392	30	tolerance	tolerance	NN
cord-261028-sxux2ujo	392	31	.	.	.
cord-261028-sxux2ujo	393	1	This	this	DT
cord-261028-sxux2ujo	393	2	is	be	VBZ
cord-261028-sxux2ujo	393	3	a	a	DT
cord-261028-sxux2ujo	393	4	most	most	RBS
cord-261028-sxux2ujo	393	5	exciting	exciting	JJ
cord-261028-sxux2ujo	393	6	time	time	NN
cord-261028-sxux2ujo	393	7	for	for	IN
cord-261028-sxux2ujo	393	8	tumor	tumor	NN
cord-261028-sxux2ujo	393	9	immunology	immunology	NN
cord-261028-sxux2ujo	393	10	,	,	,
cord-261028-sxux2ujo	393	11	as	as	IN
cord-261028-sxux2ujo	393	12	we	-PRON-	PRP
cord-261028-sxux2ujo	393	13	are	be	VBP
cord-261028-sxux2ujo	393	14	seeing	see	VBG
cord-261028-sxux2ujo	393	15	the	the	DT
cord-261028-sxux2ujo	393	16	scientific	scientific	JJ
cord-261028-sxux2ujo	393	17	understanding	understanding	NN
cord-261028-sxux2ujo	393	18	of	of	IN
cord-261028-sxux2ujo	393	19	cancer	cancer	NN
cord-261028-sxux2ujo	393	20	translated	translate	VBN
cord-261028-sxux2ujo	393	21	into	into	IN
cord-261028-sxux2ujo	393	22	human	human	JJ
cord-261028-sxux2ujo	393	23	clinical	clinical	JJ
cord-261028-sxux2ujo	393	24	trials	trial	NNS
cord-261028-sxux2ujo	393	25	.	.	.
cord-261028-sxux2ujo	394	1	The	the	DT
cord-261028-sxux2ujo	394	2	application	application	NN
cord-261028-sxux2ujo	394	3	of	of	IN
cord-261028-sxux2ujo	394	4	therapies	therapy	NNS
cord-261028-sxux2ujo	394	5	targeting	target	VBG
cord-261028-sxux2ujo	394	6	the	the	DT
cord-261028-sxux2ujo	394	7	STING	sting	NN
cord-261028-sxux2ujo	394	8	pathway	pathway	NN
cord-261028-sxux2ujo	394	9	to	to	TO
cord-261028-sxux2ujo	394	10	mimic	mimic	VB
cord-261028-sxux2ujo	394	11	and	and	CC
cord-261028-sxux2ujo	394	12	enhance	enhance	VB
cord-261028-sxux2ujo	394	13	the	the	DT
cord-261028-sxux2ujo	394	14	endogenous	endogenous	JJ
cord-261028-sxux2ujo	394	15	immune	immune	JJ
cord-261028-sxux2ujo	394	16	response	response	NN
cord-261028-sxux2ujo	394	17	to	to	IN
cord-261028-sxux2ujo	394	18	cancer	cancer	NN
cord-261028-sxux2ujo	394	19	is	be	VBZ
cord-261028-sxux2ujo	394	20	currently	currently	RB
cord-261028-sxux2ujo	394	21	underway	underway	JJ
cord-261028-sxux2ujo	394	22	,	,	,
cord-261028-sxux2ujo	394	23	and	and	CC
cord-261028-sxux2ujo	394	24	results	result	NNS
cord-261028-sxux2ujo	394	25	from	from	IN
cord-261028-sxux2ujo	394	26	these	these	DT
cord-261028-sxux2ujo	394	27	trials	trial	NNS
cord-261028-sxux2ujo	394	28	will	will	MD
cord-261028-sxux2ujo	394	29	help	help	VB
cord-261028-sxux2ujo	394	30	enhance	enhance	VB
cord-261028-sxux2ujo	394	31	our	-PRON-	PRP$
cord-261028-sxux2ujo	394	32	understanding	understanding	NN
cord-261028-sxux2ujo	394	33	of	of	IN
cord-261028-sxux2ujo	394	34	cancer	cancer	NN
cord-261028-sxux2ujo	394	35	immunity	immunity	NN
cord-261028-sxux2ujo	394	36	,	,	,
cord-261028-sxux2ujo	394	37	offering	offer	VBG
cord-261028-sxux2ujo	394	38	a	a	DT
cord-261028-sxux2ujo	394	39	hopeful	hopeful	JJ
cord-261028-sxux2ujo	394	40	future	future	NN
cord-261028-sxux2ujo	394	41	for	for	IN
cord-261028-sxux2ujo	394	42	enlisting	enlist	VBG
cord-261028-sxux2ujo	394	43	the	the	DT
cord-261028-sxux2ujo	394	44	immune	immune	JJ
cord-261028-sxux2ujo	394	45	system	system	NN
cord-261028-sxux2ujo	394	46	in	in	IN
cord-261028-sxux2ujo	394	47	the	the	DT
cord-261028-sxux2ujo	394	48	fight	fight	NN
cord-261028-sxux2ujo	394	49	against	against	IN
cord-261028-sxux2ujo	394	50	cancer	cancer	NN
cord-261028-sxux2ujo	394	51	.	.	.
cord-261028-sxux2ujo	395	1	The	the	DT
cord-261028-sxux2ujo	395	2	STING	sting	NN
cord-261028-sxux2ujo	395	3	signaling	signal	VBG
cord-261028-sxux2ujo	395	4	pathway	pathway	NN
cord-261028-sxux2ujo	395	5	.	.	.
cord-261028-sxux2ujo	396	1	Cytosolic	Cytosolic	NNP
cord-261028-sxux2ujo	396	2	DNA	DNA	NNP
cord-261028-sxux2ujo	396	3	is	be	VBZ
cord-261028-sxux2ujo	396	4	primarily	primarily	RB
cord-261028-sxux2ujo	396	5	sensed	sense	VBN
cord-261028-sxux2ujo	396	6	by	by	IN
cord-261028-sxux2ujo	396	7	cyclic	cyclic	JJ
cord-261028-sxux2ujo	396	8	-	-	HYPH
cord-261028-sxux2ujo	396	9	GMP	GMP	NNP
cord-261028-sxux2ujo	396	10	-	-	HYPH
cord-261028-sxux2ujo	396	11	AMP	AMP	NNP
cord-261028-sxux2ujo	396	12	synthase	synthase	NN
cord-261028-sxux2ujo	396	13	(	(	-LRB-
cord-261028-sxux2ujo	396	14	cGAS	cGAS	NNP
cord-261028-sxux2ujo	396	15	)	)	-RRB-
cord-261028-sxux2ujo	396	16	,	,	,
cord-261028-sxux2ujo	396	17	which	which	WDT
cord-261028-sxux2ujo	396	18	generates	generate	VBZ
cord-261028-sxux2ujo	396	19	cyclic	cyclic	JJ
cord-261028-sxux2ujo	396	20	GMP	GMP	NNP
cord-261028-sxux2ujo	396	21	-	-	HYPH
cord-261028-sxux2ujo	396	22	AMP	AMP	NNP
cord-261028-sxux2ujo	396	23	(	(	-LRB-
cord-261028-sxux2ujo	396	24	cGAMP	cGAMP	NNP
cord-261028-sxux2ujo	396	25	)	)	-RRB-
cord-261028-sxux2ujo	396	26	from	from	IN
cord-261028-sxux2ujo	396	27	guanosine	guanosine	JJ
cord-261028-sxux2ujo	396	28	triphosphate	triphosphate	NN
cord-261028-sxux2ujo	396	29	(	(	-LRB-
cord-261028-sxux2ujo	396	30	GTP	GTP	NNP
cord-261028-sxux2ujo	396	31	)	)	-RRB-
cord-261028-sxux2ujo	396	32	and	and	CC
cord-261028-sxux2ujo	396	33	adenosine	adenosine	NN
cord-261028-sxux2ujo	396	34	triphosphate	triphosphate	NN
cord-261028-sxux2ujo	396	35	(	(	-LRB-
cord-261028-sxux2ujo	396	36	ATP	ATP	NNP
cord-261028-sxux2ujo	396	37	)	)	-RRB-
cord-261028-sxux2ujo	396	38	.	.	.
cord-261028-sxux2ujo	397	1	cGAMP	cGAMP	NNP
cord-261028-sxux2ujo	397	2	functions	function	NNS
cord-261028-sxux2ujo	397	3	as	as	IN
cord-261028-sxux2ujo	397	4	a	a	DT
cord-261028-sxux2ujo	397	5	second	second	JJ
cord-261028-sxux2ujo	397	6	messenger	messenger	NN
cord-261028-sxux2ujo	397	7	that	that	WDT
cord-261028-sxux2ujo	397	8	binds	bind	VBZ
cord-261028-sxux2ujo	397	9	to	to	IN
cord-261028-sxux2ujo	397	10	and	and	CC
cord-261028-sxux2ujo	397	11	activates	activate	VBZ
cord-261028-sxux2ujo	397	12	STING	sting	NN
cord-261028-sxux2ujo	397	13	,	,	,
cord-261028-sxux2ujo	397	14	resulting	result	VBG
cord-261028-sxux2ujo	397	15	in	in	IN
cord-261028-sxux2ujo	397	16	its	-PRON-	PRP$
cord-261028-sxux2ujo	397	17	trafficking	trafficking	NN
cord-261028-sxux2ujo	397	18	from	from	IN
cord-261028-sxux2ujo	397	19	the	the	DT
cord-261028-sxux2ujo	397	20	ER	ER	NNP
cord-261028-sxux2ujo	397	21	to	to	IN
cord-261028-sxux2ujo	397	22	the	the	DT
cord-261028-sxux2ujo	397	23	Golgi	Golgi	NNP
cord-261028-sxux2ujo	397	24	and	and	CC
cord-261028-sxux2ujo	397	25	on	on	IN
cord-261028-sxux2ujo	397	26	to	to	IN
cord-261028-sxux2ujo	397	27	perinuclear	perinuclear	NNP
cord-261028-sxux2ujo	397	28	endosomes	endosome	NNS
cord-261028-sxux2ujo	397	29	where	where	WRB
cord-261028-sxux2ujo	397	30	it	-PRON-	PRP
cord-261028-sxux2ujo	397	31	mediates	mediate	VBZ
cord-261028-sxux2ujo	397	32	subsequent	subsequent	JJ
cord-261028-sxux2ujo	397	33	signaling	signaling	NN
cord-261028-sxux2ujo	397	34	via	via	IN
cord-261028-sxux2ujo	397	35	phosphorylation	phosphorylation	NN
cord-261028-sxux2ujo	397	36	of	of	IN
cord-261028-sxux2ujo	397	37	tank	tank	NN
cord-261028-sxux2ujo	397	38	-	-	HYPH
cord-261028-sxux2ujo	397	39	binding	bind	VBG
cord-261028-sxux2ujo	397	40	kinase	kinase	NN
cord-261028-sxux2ujo	397	41	1	1	CD
cord-261028-sxux2ujo	397	42	(	(	-LRB-
cord-261028-sxux2ujo	397	43	TBK1	TBK1	NNP
cord-261028-sxux2ujo	397	44	)	)	-RRB-
cord-261028-sxux2ujo	397	45	,	,	,
cord-261028-sxux2ujo	397	46	IRF3	IRF3	NNP
cord-261028-sxux2ujo	397	47	,	,	,
cord-261028-sxux2ujo	397	48	and	and	CC
cord-261028-sxux2ujo	397	49	NF	NF	NNP
cord-261028-sxux2ujo	397	50	-	-	HYPH
cord-261028-sxux2ujo	397	51	κB	κB	NNP
cord-261028-sxux2ujo	397	52	,	,	,
cord-261028-sxux2ujo	397	53	which	which	WDT
cord-261028-sxux2ujo	397	54	induce	induce	VBP
cord-261028-sxux2ujo	397	55	transcription	transcription	NN
cord-261028-sxux2ujo	397	56	of	of	IN
cord-261028-sxux2ujo	397	57	type	type	NN
cord-261028-sxux2ujo	397	58	I	-PRON-	PRP
cord-261028-sxux2ujo	397	59	IFNs	ifn	NNS
cord-261028-sxux2ujo	397	60	and	and	CC
cord-261028-sxux2ujo	397	61	other	other	JJ
cord-261028-sxux2ujo	397	62	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	397	63	genes	gene	NNS
cord-261028-sxux2ujo	397	64	.	.	.
cord-261028-sxux2ujo	398	1	DDX41	DDX41	NNP
cord-261028-sxux2ujo	398	2	,	,	,
cord-261028-sxux2ujo	398	3	ZBP1	ZBP1	NNP
cord-261028-sxux2ujo	398	4	,	,	,
cord-261028-sxux2ujo	398	5	DNA	DNA	NNP
cord-261028-sxux2ujo	398	6	-	-	HYPH
cord-261028-sxux2ujo	398	7	PK	PK	NNP
cord-261028-sxux2ujo	398	8	,	,	,
cord-261028-sxux2ujo	398	9	and	and	CC
cord-261028-sxux2ujo	398	10	IFI16	ifi16	NN
cord-261028-sxux2ujo	398	11	can	can	MD
cord-261028-sxux2ujo	398	12	also	also	RB
cord-261028-sxux2ujo	398	13	act	act	VB
cord-261028-sxux2ujo	398	14	as	as	IN
cord-261028-sxux2ujo	398	15	sensors	sensor	NNS
cord-261028-sxux2ujo	398	16	of	of	IN
cord-261028-sxux2ujo	398	17	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	398	18	DNA	dna	NN
cord-261028-sxux2ujo	398	19	with	with	IN
cord-261028-sxux2ujo	398	20	similar	similar	JJ
cord-261028-sxux2ujo	398	21	downsream	downsream	NN
cord-261028-sxux2ujo	398	22	effects	effect	NNS
cord-261028-sxux2ujo	398	23	on	on	IN
cord-261028-sxux2ujo	398	24	STING	sting	NN
cord-261028-sxux2ujo	398	25	.	.	.
cord-261028-sxux2ujo	399	1	Page	page	NN
cord-261028-sxux2ujo	399	2	24	24	CD
cord-261028-sxux2ujo	399	3	Mol	Mol	NNP
cord-261028-sxux2ujo	399	4	Immunol	Immunol	NNP
cord-261028-sxux2ujo	399	5	.	.	.
cord-261028-sxux2ujo	400	1	Author	author	NN
cord-261028-sxux2ujo	400	2	manuscript	manuscript	NN
cord-261028-sxux2ujo	400	3	;	;	:
cord-261028-sxux2ujo	400	4	available	available	JJ
cord-261028-sxux2ujo	400	5	in	in	IN
cord-261028-sxux2ujo	400	6	PMC	PMC	NNP
cord-261028-sxux2ujo	400	7	2019	2019	CD
cord-261028-sxux2ujo	400	8	September	September	NNP
cord-261028-sxux2ujo	400	9	30	30	CD
cord-261028-sxux2ujo	400	10	.	.	.
cord-261028-sxux2ujo	401	1	STING	sting	NN
cord-261028-sxux2ujo	401	2	-	-	HYPH
cord-261028-sxux2ujo	401	3	mediated	mediate	VBN
cord-261028-sxux2ujo	401	4	induction	induction	NN
cord-261028-sxux2ujo	401	5	of	of	IN
cord-261028-sxux2ujo	401	6	type	type	NN
cord-261028-sxux2ujo	402	1	I	-PRON-	PRP
cord-261028-sxux2ujo	402	2	IFN	IFN	NNP
cord-261028-sxux2ujo	402	3	in	in	IN
cord-261028-sxux2ujo	402	4	DCs	dc	NNS
cord-261028-sxux2ujo	402	5	upon	upon	IN
cord-261028-sxux2ujo	402	6	sensing	sensing	NN
cord-261028-sxux2ujo	402	7	of	of	IN
cord-261028-sxux2ujo	402	8	tumor	tumor	NN
cord-261028-sxux2ujo	402	9	DNA	dna	NN
cord-261028-sxux2ujo	402	10	.	.	.
cord-261028-sxux2ujo	403	1	DNA	dna	NN
cord-261028-sxux2ujo	403	2	damaging	damage	VBG
cord-261028-sxux2ujo	403	3	therapy	therapy	NN
cord-261028-sxux2ujo	403	4	results	result	NNS
cord-261028-sxux2ujo	403	5	in	in	IN
cord-261028-sxux2ujo	403	6	the	the	DT
cord-261028-sxux2ujo	403	7	induction	induction	NN
cord-261028-sxux2ujo	403	8	of	of	IN
cord-261028-sxux2ujo	403	9	cell	cell	NN
cord-261028-sxux2ujo	403	10	death	death	NN
cord-261028-sxux2ujo	403	11	,	,	,
cord-261028-sxux2ujo	403	12	nucleosome	nucleosome	NN
cord-261028-sxux2ujo	403	13	release	release	NN
cord-261028-sxux2ujo	403	14	,	,	,
cord-261028-sxux2ujo	403	15	mitochondrial	mitochondrial	JJ
cord-261028-sxux2ujo	403	16	damage	damage	NN
cord-261028-sxux2ujo	403	17	that	that	WDT
cord-261028-sxux2ujo	403	18	are	be	VBP
cord-261028-sxux2ujo	403	19	endocytosed	endocytose	VBN
cord-261028-sxux2ujo	403	20	by	by	IN
cord-261028-sxux2ujo	403	21	DCs	DCs	NNP
cord-261028-sxux2ujo	403	22	.	.	.
cord-261028-sxux2ujo	404	1	Upon	upon	IN
cord-261028-sxux2ujo	404	2	escape	escape	NN
cord-261028-sxux2ujo	404	3	of	of	IN
cord-261028-sxux2ujo	404	4	endosomal	endosomal	NNP
cord-261028-sxux2ujo	404	5	tumor	tumor	NN
cord-261028-sxux2ujo	404	6	-	-	HYPH
cord-261028-sxux2ujo	404	7	derived	derive	VBN
cord-261028-sxux2ujo	404	8	DNA	dna	NN
cord-261028-sxux2ujo	404	9	into	into	IN
cord-261028-sxux2ujo	404	10	the	the	DT
cord-261028-sxux2ujo	404	11	cytosol	cytosol	NN
cord-261028-sxux2ujo	404	12	,	,	,
cord-261028-sxux2ujo	404	13	tumor	tumor	NN
cord-261028-sxux2ujo	404	14	-	-	HYPH
cord-261028-sxux2ujo	404	15	DNA	dna	NN
cord-261028-sxux2ujo	404	16	can	can	MD
cord-261028-sxux2ujo	404	17	interact	interact	VB
cord-261028-sxux2ujo	404	18	with	with	IN
cord-261028-sxux2ujo	404	19	cGAS	cgas	NN
cord-261028-sxux2ujo	404	20	which	which	WDT
cord-261028-sxux2ujo	404	21	results	result	VBZ
cord-261028-sxux2ujo	404	22	in	in	IN
cord-261028-sxux2ujo	404	23	the	the	DT
cord-261028-sxux2ujo	404	24	induction	induction	NN
cord-261028-sxux2ujo	404	25	of	of	IN
cord-261028-sxux2ujo	404	26	CDN	CDN	NNP
cord-261028-sxux2ujo	404	27	and	and	CC
cord-261028-sxux2ujo	404	28	the	the	DT
cord-261028-sxux2ujo	404	29	activation	activation	NN
cord-261028-sxux2ujo	404	30	of	of	IN
cord-261028-sxux2ujo	404	31	STING	sting	NN
cord-261028-sxux2ujo	404	32	.	.	.
cord-261028-sxux2ujo	405	1	Downstream	downstream	JJ
cord-261028-sxux2ujo	405	2	signaling	signal	VBG
cord-261028-sxux2ujo	405	3	from	from	IN
cord-261028-sxux2ujo	405	4	STING	sting	NN
cord-261028-sxux2ujo	405	5	induces	induce	VBZ
cord-261028-sxux2ujo	405	6	pro	pro	JJ
cord-261028-sxux2ujo	405	7	-	-	JJ
cord-261028-sxux2ujo	405	8	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	405	9	genes	gene	NNS
cord-261028-sxux2ujo	405	10	,	,	,
cord-261028-sxux2ujo	405	11	including	include	VBG
cord-261028-sxux2ujo	405	12	type	type	NN
cord-261028-sxux2ujo	405	13	I	-PRON-	PRP
cord-261028-sxux2ujo	405	14	IFNs	ifns	VBP
cord-261028-sxux2ujo	405	15	.	.	.
cord-261028-sxux2ujo	406	1	In	in	IN
cord-261028-sxux2ujo	406	2	parallel	parallel	JJ
cord-261028-sxux2ujo	406	3	,	,	,
cord-261028-sxux2ujo	406	4	protein	protein	NN
cord-261028-sxux2ujo	406	5	escape	escape	NN
cord-261028-sxux2ujo	406	6	from	from	IN
cord-261028-sxux2ujo	406	7	endosomal	endosomal	NNP
cord-261028-sxux2ujo	406	8	degradation	degradation	NN
cord-261028-sxux2ujo	406	9	promotes	promote	VBZ
cord-261028-sxux2ujo	406	10	cross	cross	NN
cord-261028-sxux2ujo	406	11	-	-	NN
cord-261028-sxux2ujo	406	12	presentation	presentation	NN
cord-261028-sxux2ujo	406	13	in	in	IN
cord-261028-sxux2ujo	406	14	MHC	MHC	NNP
cord-261028-sxux2ujo	406	15	class	class	NN
cord-261028-sxux2ujo	406	16	I.	i.	NN
cord-261028-sxux2ujo	406	17	Immune	Immune	NNP
cord-261028-sxux2ujo	406	18	responses	response	NNS
cord-261028-sxux2ujo	406	19	dependent	dependent	JJ
cord-261028-sxux2ujo	406	20	on	on	IN
cord-261028-sxux2ujo	406	21	type	type	NN
cord-261028-sxux2ujo	407	1	I	-PRON-	PRP
cord-261028-sxux2ujo	407	2	IFN	IFN	NNP
cord-261028-sxux2ujo	407	3	,	,	,
cord-261028-sxux2ujo	407	4	STING	sting	VB
cord-261028-sxux2ujo	407	5	and	and	CC
cord-261028-sxux2ujo	407	6	DAMP	damp	VB
cord-261028-sxux2ujo	407	7	(	(	-LRB-
cord-261028-sxux2ujo	407	8	DNA	DNA	NNP
cord-261028-sxux2ujo	407	9	)	)	-RRB-
cord-261028-sxux2ujo	407	10	.	.	.
cord-261028-sxux2ujo	407	11	 	 	_SP
cord-261028-sxux2ujo	408	1	cGAS	cGAS	NNP
cord-261028-sxux2ujo	408	2	produces	produce	VBZ
cord-261028-sxux2ujo	408	3	a	a	DT
cord-261028-sxux2ujo	408	4	2'−5'-linked	2'−5'-linked	CD
cord-261028-sxux2ujo	408	5	cyclic	cyclic	NN
cord-261028-sxux2ujo	408	6	dinucleotide	dinucleotide	NN
cord-261028-sxux2ujo	408	7	second	second	JJ
cord-261028-sxux2ujo	408	8	messenger	messenger	NN
cord-261028-sxux2ujo	408	9	that	that	WDT
cord-261028-sxux2ujo	408	10	activates	activate	VBZ
cord-261028-sxux2ujo	408	11	STING	STING	NNP
cord-261028-sxux2ujo	408	12	Cellular	Cellular	NNP
cord-261028-sxux2ujo	408	13	mechanisms	mechanism	NNS
cord-261028-sxux2ujo	408	14	governing	govern	VBG
cord-261028-sxux2ujo	408	15	cross	cross	NN
cord-261028-sxux2ujo	408	16	-	-	NN
cord-261028-sxux2ujo	408	17	presentation	presentation	NN
cord-261028-sxux2ujo	408	18	of	of	IN
cord-261028-sxux2ujo	408	19	exogenous	exogenous	JJ
cord-261028-sxux2ujo	408	20	antigens	antigen	NNS
cord-261028-sxux2ujo	408	21	Early	early	RB
cord-261028-sxux2ujo	408	22	phagosomes	phagosomes	JJ
cord-261028-sxux2ujo	408	23	in	in	IN
cord-261028-sxux2ujo	408	24	dendritic	dendritic	JJ
cord-261028-sxux2ujo	408	25	cells	cell	NNS
cord-261028-sxux2ujo	408	26	form	form	VBP
cord-261028-sxux2ujo	408	27	a	a	DT
cord-261028-sxux2ujo	408	28	cellular	cellular	JJ
cord-261028-sxux2ujo	408	29	compartment	compartment	NN
cord-261028-sxux2ujo	408	30	sufficient	sufficient	JJ
cord-261028-sxux2ujo	408	31	for	for	IN
cord-261028-sxux2ujo	408	32	cross	cross	NN
cord-261028-sxux2ujo	408	33	presentation	presentation	NN
cord-261028-sxux2ujo	408	34	of	of	IN
cord-261028-sxux2ujo	408	35	exogenous	exogenous	JJ
cord-261028-sxux2ujo	408	36	antigens	antigen	NNS
cord-261028-sxux2ujo	408	37	Gene	Gene	NNP
cord-261028-sxux2ujo	408	38	regulation	regulation	NN
cord-261028-sxux2ujo	408	39	and	and	CC
cord-261028-sxux2ujo	408	40	chromatin	chromatin	NN
cord-261028-sxux2ujo	408	41	remodeling	remodeling	NN
cord-261028-sxux2ujo	408	42	by	by	IN
cord-261028-sxux2ujo	408	43	IL-12	IL-12	NNP
cord-261028-sxux2ujo	408	44	and	and	CC
cord-261028-sxux2ujo	408	45	type	type	VB
cord-261028-sxux2ujo	408	46	I	-PRON-	PRP
cord-261028-sxux2ujo	408	47	IFN	IFN	NNP
cord-261028-sxux2ujo	408	48	in	in	IN
cord-261028-sxux2ujo	408	49	programming	programming	NN
cord-261028-sxux2ujo	408	50	for	for	IN
cord-261028-sxux2ujo	408	51	CD8	CD8	NNP
cord-261028-sxux2ujo	408	52	T	T	NNP
cord-261028-sxux2ujo	408	53	cell	cell	NN
cord-261028-sxux2ujo	408	54	effector	effector	NN
cord-261028-sxux2ujo	408	55	function	function	NN
cord-261028-sxux2ujo	408	56	and	and	CC
cord-261028-sxux2ujo	408	57	memory	memory	NN
cord-261028-sxux2ujo	408	58	Inflammation	inflammation	NN
cord-261028-sxux2ujo	408	59	-	-	HYPH
cord-261028-sxux2ujo	408	60	driven	drive	VBN
cord-261028-sxux2ujo	408	61	carcinogenesis	carcinogenesis	NN
cord-261028-sxux2ujo	408	62	is	be	VBZ
cord-261028-sxux2ujo	408	63	mediated	mediate	VBN
cord-261028-sxux2ujo	408	64	through	through	IN
cord-261028-sxux2ujo	408	65	STING	sting	NN
cord-261028-sxux2ujo	408	66	Diverse	diverse	JJ
cord-261028-sxux2ujo	408	67	roles	role	NNS
cord-261028-sxux2ujo	408	68	of	of	IN
cord-261028-sxux2ujo	408	69	STING	sting	NN
cord-261028-sxux2ujo	408	70	-	-	HYPH
cord-261028-sxux2ujo	408	71	dependent	dependent	JJ
cord-261028-sxux2ujo	408	72	signaling	signaling	NN
cord-261028-sxux2ujo	408	73	on	on	IN
cord-261028-sxux2ujo	408	74	the	the	DT
cord-261028-sxux2ujo	408	75	development	development	NN
cord-261028-sxux2ujo	408	76	of	of	IN
cord-261028-sxux2ujo	408	77	cancer	cancer	NN
cord-261028-sxux2ujo	408	78	Intracellular	Intracellular	NNP
cord-261028-sxux2ujo	408	79	mechanisms	mechanism	NNS
cord-261028-sxux2ujo	408	80	of	of	IN
cord-261028-sxux2ujo	408	81	antigen	antigen	NN
cord-261028-sxux2ujo	408	82	cross	cross	JJ
cord-261028-sxux2ujo	408	83	presentation	presentation	NN
cord-261028-sxux2ujo	408	84	in	in	IN
cord-261028-sxux2ujo	408	85	dendritic	dendritic	JJ
cord-261028-sxux2ujo	408	86	cells	cell	NNS
cord-261028-sxux2ujo	409	1	Toll	toll	NN
cord-261028-sxux2ujo	409	2	-	-	HYPH
cord-261028-sxux2ujo	409	3	like	like	JJ
cord-261028-sxux2ujo	409	4	receptor	receptor	NN
cord-261028-sxux2ujo	409	5	4-dependent	4-dependent	CD
cord-261028-sxux2ujo	409	6	contribution	contribution	NN
cord-261028-sxux2ujo	409	7	of	of	IN
cord-261028-sxux2ujo	409	8	the	the	DT
cord-261028-sxux2ujo	409	9	immune	immune	JJ
cord-261028-sxux2ujo	409	10	system	system	NN
cord-261028-sxux2ujo	409	11	to	to	IN
cord-261028-sxux2ujo	409	12	anticancer	anticancer	JJ
cord-261028-sxux2ujo	409	13	chemotherapy	chemotherapy	NN
cord-261028-sxux2ujo	409	14	and	and	CC
cord-261028-sxux2ujo	409	15	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	409	16	Murine	murine	NN
cord-261028-sxux2ujo	410	1	melanomainfiltrating	melanomainfiltrate	VBG
cord-261028-sxux2ujo	410	2	dendritic	dendritic	JJ
cord-261028-sxux2ujo	410	3	cells	cell	NNS
cord-261028-sxux2ujo	410	4	are	be	VBP
cord-261028-sxux2ujo	410	5	defective	defective	JJ
cord-261028-sxux2ujo	410	6	in	in	IN
cord-261028-sxux2ujo	410	7	antigen	antigen	NN
cord-261028-sxux2ujo	410	8	presenting	present	VBG
cord-261028-sxux2ujo	410	9	function	function	NN
cord-261028-sxux2ujo	410	10	regardless	regardless	RB
cord-261028-sxux2ujo	410	11	of	of	IN
cord-261028-sxux2ujo	410	12	the	the	DT
cord-261028-sxux2ujo	410	13	presence	presence	NN
cord-261028-sxux2ujo	410	14	of	of	IN
cord-261028-sxux2ujo	410	15	CD4CD25	cd4cd25	CD
cord-261028-sxux2ujo	410	16	regulatory	regulatory	JJ
cord-261028-sxux2ujo	410	17	T	t	NN
cord-261028-sxux2ujo	410	18	cells	cell	NNS
cord-261028-sxux2ujo	410	19	Immunomodulatory	immunomodulatory	JJ
cord-261028-sxux2ujo	410	20	actions	action	NNS
cord-261028-sxux2ujo	410	21	of	of	IN
cord-261028-sxux2ujo	410	22	xanthenone	xanthenone	NNP
cord-261028-sxux2ujo	410	23	anticancer	anticancer	JJ
cord-261028-sxux2ujo	410	24	agents	agent	NNS
cord-261028-sxux2ujo	410	25	Radiotherapy	Radiotherapy	NNP
cord-261028-sxux2ujo	411	1	combined	combine	VBN
cord-261028-sxux2ujo	411	2	with	with	IN
cord-261028-sxux2ujo	411	3	novel	novel	JJ
cord-261028-sxux2ujo	411	4	STING	sting	NN
cord-261028-sxux2ujo	411	5	-	-	HYPH
cord-261028-sxux2ujo	411	6	targeting	target	VBG
cord-261028-sxux2ujo	411	7	oligonucleotides	oligonucleotide	NNS
cord-261028-sxux2ujo	411	8	results	result	NNS
cord-261028-sxux2ujo	411	9	in	in	IN
cord-261028-sxux2ujo	411	10	regression	regression	NN
cord-261028-sxux2ujo	411	11	of	of	IN
cord-261028-sxux2ujo	411	12	established	establish	VBN
cord-261028-sxux2ujo	411	13	tumors	tumor	NNS
cord-261028-sxux2ujo	411	14	MHC	MHC	NNP
cord-261028-sxux2ujo	411	15	class	class	NN
cord-261028-sxux2ujo	411	16	I	-PRON-	PRP
cord-261028-sxux2ujo	411	17	endosomal	endosomal	VBD
cord-261028-sxux2ujo	411	18	and	and	CC
cord-261028-sxux2ujo	411	19	lysosomal	lysosomal	JJ
cord-261028-sxux2ujo	411	20	trafficking	trafficking	NN
cord-261028-sxux2ujo	411	21	coincides	coincide	VBZ
cord-261028-sxux2ujo	411	22	with	with	IN
cord-261028-sxux2ujo	411	23	exogenous	exogenous	JJ
cord-261028-sxux2ujo	411	24	antigen	antigen	NN
cord-261028-sxux2ujo	411	25	loading	loading	NN
cord-261028-sxux2ujo	411	26	in	in	IN
cord-261028-sxux2ujo	411	27	dendritic	dendritic	JJ
cord-261028-sxux2ujo	411	28	cells	cell	NNS
cord-261028-sxux2ujo	411	29	Cross	Cross	NNP
cord-261028-sxux2ujo	411	30	-	-	NN
cord-261028-sxux2ujo	411	31	presentation	presentation	NN
cord-261028-sxux2ujo	411	32	of	of	IN
cord-261028-sxux2ujo	411	33	viral	viral	JJ
cord-261028-sxux2ujo	411	34	and	and	CC
cord-261028-sxux2ujo	411	35	self	self	NN
cord-261028-sxux2ujo	411	36	antigens	antigen	NNS
cord-261028-sxux2ujo	411	37	by	by	IN
cord-261028-sxux2ujo	411	38	skin	skin	NN
cord-261028-sxux2ujo	411	39	-	-	HYPH
cord-261028-sxux2ujo	411	40	derived	derive	VBN
cord-261028-sxux2ujo	411	41	CD103	cd103	NN
cord-261028-sxux2ujo	411	42	+	+	CD
cord-261028-sxux2ujo	411	43	dendritic	dendritic	JJ
cord-261028-sxux2ujo	411	44	cells	cell	NNS
cord-261028-sxux2ujo	411	45	Intestinal	intestinal	JJ
cord-261028-sxux2ujo	411	46	dendritic	dendritic	JJ
cord-261028-sxux2ujo	411	47	cells	cell	NNS
cord-261028-sxux2ujo	411	48	in	in	IN
cord-261028-sxux2ujo	411	49	the	the	DT
cord-261028-sxux2ujo	411	50	regulation	regulation	NN
cord-261028-sxux2ujo	411	51	of	of	IN
cord-261028-sxux2ujo	411	52	mucosal	mucosal	JJ
cord-261028-sxux2ujo	411	53	immunity	immunity	NN
cord-261028-sxux2ujo	411	54	Cross	Cross	NNP
cord-261028-sxux2ujo	411	55	-	-	NN
cord-261028-sxux2ujo	411	56	priming	priming	NN
cord-261028-sxux2ujo	411	57	for	for	IN
cord-261028-sxux2ujo	411	58	a	a	DT
cord-261028-sxux2ujo	411	59	secondary	secondary	JJ
cord-261028-sxux2ujo	411	60	cytotoxic	cytotoxic	JJ
cord-261028-sxux2ujo	411	61	response	response	NN
cord-261028-sxux2ujo	411	62	to	to	IN
cord-261028-sxux2ujo	411	63	minor	minor	JJ
cord-261028-sxux2ujo	411	64	H	h	NN
cord-261028-sxux2ujo	411	65	antigens	antigen	NNS
cord-261028-sxux2ujo	411	66	with	with	IN
cord-261028-sxux2ujo	411	67	H-2	H-2	NNP
cord-261028-sxux2ujo	411	68	congenic	congenic	NNP
cord-261028-sxux2ujo	411	69	cells	cell	NNS
cord-261028-sxux2ujo	411	70	which	which	WDT
cord-261028-sxux2ujo	411	71	do	do	VBP
cord-261028-sxux2ujo	411	72	not	not	RB
cord-261028-sxux2ujo	411	73	cross	cross	VB
cord-261028-sxux2ujo	411	74	-	-	JJ
cord-261028-sxux2ujo	411	75	react	react	VB
cord-261028-sxux2ujo	411	76	in	in	IN
cord-261028-sxux2ujo	411	77	the	the	DT
cord-261028-sxux2ujo	411	78	cytotoxic	cytotoxic	JJ
cord-261028-sxux2ujo	411	79	assay	assay	NN
cord-261028-sxux2ujo	411	80	Cross	Cross	NNP
cord-261028-sxux2ujo	411	81	-	-	HYPH
cord-261028-sxux2ujo	411	82	priming	prime	VBG
cord-261028-sxux2ujo	411	83	Silencing	silencing	NN
cord-261028-sxux2ujo	411	84	of	of	IN
cord-261028-sxux2ujo	411	85	Irf7	Irf7	NNP
cord-261028-sxux2ujo	411	86	pathways	pathway	NNS
cord-261028-sxux2ujo	411	87	in	in	IN
cord-261028-sxux2ujo	411	88	breast	breast	NN
cord-261028-sxux2ujo	411	89	cancer	cancer	NN
cord-261028-sxux2ujo	411	90	cells	cell	NNS
cord-261028-sxux2ujo	411	91	promotes	promote	VBZ
cord-261028-sxux2ujo	411	92	bone	bone	NN
cord-261028-sxux2ujo	411	93	metastasis	metastasis	NN
cord-261028-sxux2ujo	411	94	through	through	IN
cord-261028-sxux2ujo	411	95	immune	immune	JJ
cord-261028-sxux2ujo	411	96	escape	escape	NN
cord-261028-sxux2ujo	411	97	Apoptotic	apoptotic	JJ
cord-261028-sxux2ujo	411	98	cell	cell	NN
cord-261028-sxux2ujo	411	99	recognition	recognition	NN
cord-261028-sxux2ujo	411	100	:	:	:
cord-261028-sxux2ujo	411	101	will	will	MD
cord-261028-sxux2ujo	411	102	the	the	DT
cord-261028-sxux2ujo	411	103	real	real	JJ
cord-261028-sxux2ujo	411	104	phosphatidylserine	phosphatidylserine	NN
cord-261028-sxux2ujo	411	105	receptor(s	receptor(s	NN
cord-261028-sxux2ujo	411	106	)	)	-RRB-
cord-261028-sxux2ujo	411	107	please	please	UH
cord-261028-sxux2ujo	411	108	stand	stand	VB
cord-261028-sxux2ujo	411	109	up	up	RP
cord-261028-sxux2ujo	411	110	?	?	.
cord-261028-sxux2ujo	412	1	STING	sting	VB
cord-261028-sxux2ujo	412	2	and	and	CC
cord-261028-sxux2ujo	412	3	the	the	DT
cord-261028-sxux2ujo	412	4	innate	innate	JJ
cord-261028-sxux2ujo	412	5	immune	immune	JJ
cord-261028-sxux2ujo	412	6	response	response	NN
cord-261028-sxux2ujo	412	7	to	to	IN
cord-261028-sxux2ujo	412	8	nucleic	nucleic	JJ
cord-261028-sxux2ujo	412	9	acids	acid	NNS
cord-261028-sxux2ujo	412	10	in	in	IN
cord-261028-sxux2ujo	412	11	the	the	DT
cord-261028-sxux2ujo	412	12	cytosol	cytosol	NN
cord-261028-sxux2ujo	412	13	Spatial	Spatial	NNP
cord-261028-sxux2ujo	412	14	and	and	CC
cord-261028-sxux2ujo	412	15	mechanistic	mechanistic	JJ
cord-261028-sxux2ujo	412	16	separation	separation	NN
cord-261028-sxux2ujo	412	17	of	of	IN
cord-261028-sxux2ujo	412	18	crosspresentation	crosspresentation	NN
cord-261028-sxux2ujo	412	19	and	and	CC
cord-261028-sxux2ujo	412	20	endogenous	endogenous	JJ
cord-261028-sxux2ujo	412	21	antigen	antigen	NN
cord-261028-sxux2ujo	412	22	presentation	presentation	NN
cord-261028-sxux2ujo	412	23	Radiation	Radiation	NNP
cord-261028-sxux2ujo	412	24	as	as	IN
cord-261028-sxux2ujo	412	25	an	an	DT
cord-261028-sxux2ujo	412	26	immune	immune	JJ
cord-261028-sxux2ujo	412	27	modulator	modulator	NN
cord-261028-sxux2ujo	413	1	The	the	DT
cord-261028-sxux2ujo	413	2	efficacy	efficacy	NN
cord-261028-sxux2ujo	413	3	of	of	IN
cord-261028-sxux2ujo	413	4	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	413	5	relies	rely	VBZ
cord-261028-sxux2ujo	413	6	upon	upon	IN
cord-261028-sxux2ujo	413	7	induction	induction	NN
cord-261028-sxux2ujo	413	8	of	of	IN
cord-261028-sxux2ujo	413	9	type	type	NN
cord-261028-sxux2ujo	414	1	i	i	PRP
cord-261028-sxux2ujo	414	2	interferondependent	interferondependent	NNP
cord-261028-sxux2ujo	415	1	innate	innate	JJ
cord-261028-sxux2ujo	415	2	and	and	CC
cord-261028-sxux2ujo	415	3	adaptive	adaptive	JJ
cord-261028-sxux2ujo	415	4	immunity	immunity	NN
cord-261028-sxux2ujo	415	5	STING	sting	NN
cord-261028-sxux2ujo	415	6	ligand	ligand	NN
cord-261028-sxux2ujo	415	7	c	c	NNP
cord-261028-sxux2ujo	415	8	-	-	HYPH
cord-261028-sxux2ujo	415	9	di	di	NNP
cord-261028-sxux2ujo	415	10	-	-	HYPH
cord-261028-sxux2ujo	415	11	GMP	GMP	NNP
cord-261028-sxux2ujo	415	12	improves	improve	VBZ
cord-261028-sxux2ujo	415	13	cancer	cancer	NN
cord-261028-sxux2ujo	415	14	vaccination	vaccination	NN
cord-261028-sxux2ujo	415	15	against	against	IN
cord-261028-sxux2ujo	415	16	metastatic	metastatic	JJ
cord-261028-sxux2ujo	415	17	breast	breast	NN
cord-261028-sxux2ujo	415	18	cancer	cancer	NN
cord-261028-sxux2ujo	416	1	The	the	DT
cord-261028-sxux2ujo	416	2	Janus	Janus	NNP
cord-261028-sxux2ujo	416	3	face	face	NN
cord-261028-sxux2ujo	416	4	of	of	IN
cord-261028-sxux2ujo	416	5	dendritic	dendritic	JJ
cord-261028-sxux2ujo	416	6	cells	cell	NNS
cord-261028-sxux2ujo	416	7	in	in	IN
cord-261028-sxux2ujo	416	8	cancer	cancer	NN
cord-261028-sxux2ujo	416	9	Molecular	molecular	JJ
cord-261028-sxux2ujo	416	10	mechanisms	mechanism	NNS
cord-261028-sxux2ujo	416	11	of	of	IN
cord-261028-sxux2ujo	416	12	T	T	NNP
cord-261028-sxux2ujo	416	13	cell	cell	NN
cord-261028-sxux2ujo	416	14	co	co	NN
cord-261028-sxux2ujo	416	15	-	-	NN
cord-261028-sxux2ujo	416	16	stimulation	stimulation	NN
cord-261028-sxux2ujo	416	17	and	and	CC
cord-261028-sxux2ujo	416	18	co	co	NN
cord-261028-sxux2ujo	416	19	-	-	JJ
cord-261028-sxux2ujo	416	20	inhibition	inhibition	JJ
cord-261028-sxux2ujo	416	21	Tumor	tumor	NN
cord-261028-sxux2ujo	416	22	-	-	HYPH
cord-261028-sxux2ujo	416	23	infiltrating	infiltrate	VBG
cord-261028-sxux2ujo	416	24	DCs	dc	NNS
cord-261028-sxux2ujo	416	25	suppress	suppress	VBP
cord-261028-sxux2ujo	416	26	nucleic	nucleic	JJ
cord-261028-sxux2ujo	416	27	acid	acid	NN
cord-261028-sxux2ujo	416	28	-	-	HYPH
cord-261028-sxux2ujo	416	29	mediated	mediate	VBN
cord-261028-sxux2ujo	416	30	innate	innate	JJ
cord-261028-sxux2ujo	416	31	immune	immune	JJ
cord-261028-sxux2ujo	416	32	responses	response	NNS
cord-261028-sxux2ujo	416	33	through	through	IN
cord-261028-sxux2ujo	416	34	interactions	interaction	NNS
cord-261028-sxux2ujo	416	35	between	between	IN
cord-261028-sxux2ujo	416	36	the	the	DT
cord-261028-sxux2ujo	416	37	receptor	receptor	NN
cord-261028-sxux2ujo	416	38	TIM-3	TIM-3	NNP
cord-261028-sxux2ujo	416	39	and	and	CC
cord-261028-sxux2ujo	416	40	the	the	DT
cord-261028-sxux2ujo	416	41	alarmin	alarmin	NNP
cord-261028-sxux2ujo	416	42	HMGB1	HMGB1	NNP
cord-261028-sxux2ujo	416	43	Transcription	Transcription	NNP
cord-261028-sxux2ujo	416	44	factor	factor	NN
cord-261028-sxux2ujo	416	45	E2	E2	NNP
cord-261028-sxux2ujo	416	46	-	-	HYPH
cord-261028-sxux2ujo	416	47	2	2	NNP
cord-261028-sxux2ujo	416	48	is	be	VBZ
cord-261028-sxux2ujo	416	49	an	an	DT
cord-261028-sxux2ujo	416	50	essential	essential	JJ
cord-261028-sxux2ujo	416	51	and	and	CC
cord-261028-sxux2ujo	416	52	specific	specific	JJ
cord-261028-sxux2ujo	416	53	regulator	regulator	NN
cord-261028-sxux2ujo	416	54	of	of	IN
cord-261028-sxux2ujo	416	55	plasmacytoid	plasmacytoid	NNP
cord-261028-sxux2ujo	416	56	dendritic	dendritic	JJ
cord-261028-sxux2ujo	416	57	cell	cell	NN
cord-261028-sxux2ujo	416	58	development	development	NN
cord-261028-sxux2ujo	416	59	Structural	structural	JJ
cord-261028-sxux2ujo	416	60	mechanism	mechanism	NN
cord-261028-sxux2ujo	416	61	of	of	IN
cord-261028-sxux2ujo	416	62	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	416	63	DNA	dna	NN
cord-261028-sxux2ujo	416	64	sensing	sensing	NN
cord-261028-sxux2ujo	416	65	by	by	IN
cord-261028-sxux2ujo	416	66	cGAS	cga	VBG
cord-261028-sxux2ujo	416	67	Antigen	antigen	NN
cord-261028-sxux2ujo	416	68	processing	processing	NN
cord-261028-sxux2ujo	416	69	and	and	CC
cord-261028-sxux2ujo	416	70	remodeling	remodeling	NN
cord-261028-sxux2ujo	416	71	of	of	IN
cord-261028-sxux2ujo	416	72	the	the	DT
cord-261028-sxux2ujo	416	73	endosomal	endosomal	NNP
cord-261028-sxux2ujo	416	74	pathway	pathway	NN
cord-261028-sxux2ujo	416	75	:	:	:
cord-261028-sxux2ujo	416	76	requirements	requirement	NNS
cord-261028-sxux2ujo	416	77	for	for	IN
cord-261028-sxux2ujo	416	78	antigen	antigen	NN
cord-261028-sxux2ujo	416	79	cross	cross	JJ
cord-261028-sxux2ujo	416	80	-	-	JJ
cord-261028-sxux2ujo	416	81	presentation	presentation	JJ
cord-261028-sxux2ujo	416	82	Direct	direct	JJ
cord-261028-sxux2ujo	416	83	activation	activation	NN
cord-261028-sxux2ujo	416	84	of	of	IN
cord-261028-sxux2ujo	416	85	STING	sting	NN
cord-261028-sxux2ujo	416	86	in	in	IN
cord-261028-sxux2ujo	416	87	the	the	DT
cord-261028-sxux2ujo	416	88	tumor	tumor	NN
cord-261028-sxux2ujo	416	89	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	416	90	leads	lead	VBZ
cord-261028-sxux2ujo	416	91	to	to	IN
cord-261028-sxux2ujo	416	92	potent	potent	JJ
cord-261028-sxux2ujo	416	93	and	and	CC
cord-261028-sxux2ujo	416	94	systemic	systemic	JJ
cord-261028-sxux2ujo	416	95	tumor	tumor	NN
cord-261028-sxux2ujo	416	96	regression	regression	NN
cord-261028-sxux2ujo	416	97	and	and	CC
cord-261028-sxux2ujo	416	98	immunity	immunity	NN
cord-261028-sxux2ujo	417	1	The	the	DT
cord-261028-sxux2ujo	417	2	XC	XC	NNP
cord-261028-sxux2ujo	417	3	chemokine	chemokine	NN
cord-261028-sxux2ujo	417	4	receptor	receptor	NN
cord-261028-sxux2ujo	417	5	1	1	CD
cord-261028-sxux2ujo	417	6	is	be	VBZ
cord-261028-sxux2ujo	417	7	a	a	DT
cord-261028-sxux2ujo	417	8	conserved	conserved	JJ
cord-261028-sxux2ujo	417	9	selective	selective	JJ
cord-261028-sxux2ujo	417	10	marker	marker	NN
cord-261028-sxux2ujo	417	11	of	of	IN
cord-261028-sxux2ujo	417	12	mammalian	mammalian	JJ
cord-261028-sxux2ujo	417	13	cells	cell	NNS
cord-261028-sxux2ujo	417	14	homologous	homologous	JJ
cord-261028-sxux2ujo	417	15	to	to	TO
cord-261028-sxux2ujo	417	16	mouse	mouse	VB
cord-261028-sxux2ujo	417	17	CD8alpha+	CD8alpha+	NNP
cord-261028-sxux2ujo	417	18	dendritic	dendritic	JJ
cord-261028-sxux2ujo	417	19	cells	cell	NNS
cord-261028-sxux2ujo	417	20	STING	sting	VBP
cord-261028-sxux2ujo	417	21	pathway	pathway	NN
cord-261028-sxux2ujo	417	22	activation	activation	NN
cord-261028-sxux2ujo	417	23	stimulates	stimulate	VBZ
cord-261028-sxux2ujo	417	24	potent	potent	JJ
cord-261028-sxux2ujo	417	25	immunity	immunity	NN
cord-261028-sxux2ujo	417	26	against	against	IN
cord-261028-sxux2ujo	417	27	acute	acute	JJ
cord-261028-sxux2ujo	417	28	myeloid	myeloid	NN
cord-261028-sxux2ujo	417	29	leukemia	leukemia	NN
cord-261028-sxux2ujo	417	30	Inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	417	31	cytokines	cytokine	NNS
cord-261028-sxux2ujo	417	32	as	as	IN
cord-261028-sxux2ujo	417	33	a	a	DT
cord-261028-sxux2ujo	417	34	third	third	JJ
cord-261028-sxux2ujo	417	35	signal	signal	NN
cord-261028-sxux2ujo	417	36	for	for	IN
cord-261028-sxux2ujo	417	37	T	T	NNP
cord-261028-sxux2ujo	417	38	cell	cell	NN
cord-261028-sxux2ujo	417	39	activation	activation	NN
cord-261028-sxux2ujo	417	40	Development	development	NN
cord-261028-sxux2ujo	417	41	and	and	CC
cord-261028-sxux2ujo	417	42	functional	functional	JJ
cord-261028-sxux2ujo	417	43	specialization	specialization	NN
cord-261028-sxux2ujo	417	44	of	of	IN
cord-261028-sxux2ujo	417	45	CD103	cd103	NN
cord-261028-sxux2ujo	417	46	+	+	CD
cord-261028-sxux2ujo	417	47	dendritic	dendritic	JJ
cord-261028-sxux2ujo	417	48	cells	cell	NNS
cord-261028-sxux2ujo	418	1	Ionizing	ionize	VBG
cord-261028-sxux2ujo	418	2	radiation	radiation	NN
cord-261028-sxux2ujo	418	3	inhibition	inhibition	NN
cord-261028-sxux2ujo	418	4	of	of	IN
cord-261028-sxux2ujo	418	5	distant	distant	JJ
cord-261028-sxux2ujo	418	6	untreated	untreated	JJ
cord-261028-sxux2ujo	418	7	tumors	tumor	NNS
cord-261028-sxux2ujo	418	8	(	(	-LRB-
cord-261028-sxux2ujo	418	9	abscopal	abscopal	JJ
cord-261028-sxux2ujo	418	10	effect	effect	NN
cord-261028-sxux2ujo	418	11	)	)	-RRB-
cord-261028-sxux2ujo	418	12	is	be	VBZ
cord-261028-sxux2ujo	418	13	immune	immune	JJ
cord-261028-sxux2ujo	418	14	mediated	mediate	VBN
cord-261028-sxux2ujo	418	15	Combining	combine	VBG
cord-261028-sxux2ujo	418	16	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	418	17	and	and	CC
cord-261028-sxux2ujo	418	18	immunotherapy	immunotherapy	NN
cord-261028-sxux2ujo	418	19	:	:	:
cord-261028-sxux2ujo	419	1	a	a	DT
cord-261028-sxux2ujo	419	2	revived	revive	VBN
cord-261028-sxux2ujo	419	3	partnership	partnership	NN
cord-261028-sxux2ujo	419	4	Immune	immune	NN
cord-261028-sxux2ujo	419	5	-	-	HYPH
cord-261028-sxux2ujo	419	6	mediated	mediate	VBN
cord-261028-sxux2ujo	419	7	inhibition	inhibition	NN
cord-261028-sxux2ujo	419	8	of	of	IN
cord-261028-sxux2ujo	419	9	metastases	metastasis	NNS
cord-261028-sxux2ujo	419	10	after	after	IN
cord-261028-sxux2ujo	419	11	treatment	treatment	NN
cord-261028-sxux2ujo	419	12	with	with	IN
cord-261028-sxux2ujo	419	13	local	local	JJ
cord-261028-sxux2ujo	419	14	radiation	radiation	NN
cord-261028-sxux2ujo	419	15	and	and	CC
cord-261028-sxux2ujo	419	16	CTLA-4	CTLA-4	NNS
cord-261028-sxux2ujo	419	17	blockade	blockade	VBP
cord-261028-sxux2ujo	419	18	in	in	IN
cord-261028-sxux2ujo	419	19	a	a	DT
cord-261028-sxux2ujo	419	20	mouse	mouse	NN
cord-261028-sxux2ujo	419	21	model	model	NN
cord-261028-sxux2ujo	419	22	of	of	IN
cord-261028-sxux2ujo	419	23	breast	breast	NN
cord-261028-sxux2ujo	419	24	cancer	cancer	NN
cord-261028-sxux2ujo	419	25	STING	sting	NN
cord-261028-sxux2ujo	419	26	-	-	HYPH
cord-261028-sxux2ujo	419	27	dependent	dependent	JJ
cord-261028-sxux2ujo	419	28	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	419	29	DNA	dna	NN
cord-261028-sxux2ujo	419	30	sensing	sensing	NN
cord-261028-sxux2ujo	419	31	promotes	promote	VBZ
cord-261028-sxux2ujo	419	32	radiation	radiation	NN
cord-261028-sxux2ujo	419	33	-	-	HYPH
cord-261028-sxux2ujo	419	34	induced	induce	VBN
cord-261028-sxux2ujo	419	35	type	type	NN
cord-261028-sxux2ujo	420	1	I	-PRON-	PRP
cord-261028-sxux2ujo	420	2	interferon	interferon	NN
cord-261028-sxux2ujo	420	3	-	-	HYPH
cord-261028-sxux2ujo	420	4	dependent	dependent	JJ
cord-261028-sxux2ujo	420	5	antitumor	antitumor	JJ
cord-261028-sxux2ujo	420	6	immunity	immunity	NN
cord-261028-sxux2ujo	420	7	in	in	IN
cord-261028-sxux2ujo	420	8	immunogenic	immunogenic	JJ
cord-261028-sxux2ujo	420	9	tumors	tumor	NNS
cord-261028-sxux2ujo	420	10	Irradiation	irradiation	NN
cord-261028-sxux2ujo	420	11	and	and	CC
cord-261028-sxux2ujo	420	12	anti	anti	JJ
cord-261028-sxux2ujo	420	13	-	-	JJ
cord-261028-sxux2ujo	420	14	PD	pd	JJ
cord-261028-sxux2ujo	420	15	-	-	HYPH
cord-261028-sxux2ujo	420	16	L1	L1	NNP
cord-261028-sxux2ujo	420	17	treatment	treatment	NN
cord-261028-sxux2ujo	420	18	synergistically	synergistically	RB
cord-261028-sxux2ujo	420	19	promote	promote	VBP
cord-261028-sxux2ujo	420	20	antitumor	antitumor	JJ
cord-261028-sxux2ujo	420	21	immunity	immunity	NN
cord-261028-sxux2ujo	420	22	in	in	IN
cord-261028-sxux2ujo	420	23	mice	mouse	NNS
cord-261028-sxux2ujo	420	24	Fractionated	fractionate	VBN
cord-261028-sxux2ujo	420	25	but	but	CC
cord-261028-sxux2ujo	421	1	not	not	RB
cord-261028-sxux2ujo	421	2	single	single	JJ
cord-261028-sxux2ujo	421	3	-	-	HYPH
cord-261028-sxux2ujo	421	4	dose	dose	NN
cord-261028-sxux2ujo	421	5	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	421	6	induces	induce	VBZ
cord-261028-sxux2ujo	421	7	an	an	DT
cord-261028-sxux2ujo	421	8	immune	immune	NN
cord-261028-sxux2ujo	421	9	-	-	HYPH
cord-261028-sxux2ujo	421	10	mediated	mediate	VBN
cord-261028-sxux2ujo	421	11	abscopal	abscopal	JJ
cord-261028-sxux2ujo	421	12	effect	effect	NN
cord-261028-sxux2ujo	421	13	when	when	WRB
cord-261028-sxux2ujo	421	14	combined	combine	VBN
cord-261028-sxux2ujo	421	15	with	with	IN
cord-261028-sxux2ujo	421	16	anti	anti	NNS
cord-261028-sxux2ujo	421	17	-	-	JJ
cord-261028-sxux2ujo	421	18	CTLA-4	ctla-4	JJ
cord-261028-sxux2ujo	421	19	antibody	antibody	NN
cord-261028-sxux2ujo	421	20	Type	type	NN
cord-261028-sxux2ujo	422	1	I	-PRON-	PRP
cord-261028-sxux2ujo	422	2	interferon	interferon	RB
cord-261028-sxux2ujo	422	3	is	be	VBZ
cord-261028-sxux2ujo	422	4	selectively	selectively	RB
cord-261028-sxux2ujo	422	5	required	require	VBN
cord-261028-sxux2ujo	422	6	by	by	IN
cord-261028-sxux2ujo	422	7	dendritic	dendritic	JJ
cord-261028-sxux2ujo	422	8	cells	cell	NNS
cord-261028-sxux2ujo	422	9	for	for	IN
cord-261028-sxux2ujo	422	10	immune	immune	JJ
cord-261028-sxux2ujo	422	11	rejection	rejection	NN
cord-261028-sxux2ujo	422	12	of	of	IN
cord-261028-sxux2ujo	422	13	tumors	tumor	NNS
cord-261028-sxux2ujo	422	14	Recruitment	recruitment	NN
cord-261028-sxux2ujo	422	15	and	and	CC
cord-261028-sxux2ujo	422	16	differentiation	differentiation	NN
cord-261028-sxux2ujo	422	17	of	of	IN
cord-261028-sxux2ujo	422	18	conventional	conventional	JJ
cord-261028-sxux2ujo	422	19	dendritic	dendritic	JJ
cord-261028-sxux2ujo	422	20	cell	cell	NN
cord-261028-sxux2ujo	422	21	precursors	precursor	NNS
cord-261028-sxux2ujo	422	22	in	in	IN
cord-261028-sxux2ujo	422	23	tumors	tumor	NNS
cord-261028-sxux2ujo	423	1	Tumors	tumor	NNS
cord-261028-sxux2ujo	423	2	suppress	suppress	VBP
cord-261028-sxux2ujo	423	3	in	in	IN
cord-261028-sxux2ujo	423	4	situ	situ	JJ
cord-261028-sxux2ujo	423	5	proliferation	proliferation	NN
cord-261028-sxux2ujo	423	6	of	of	IN
cord-261028-sxux2ujo	423	7	cytotoxic	cytotoxic	JJ
cord-261028-sxux2ujo	423	8	T	t	NN
cord-261028-sxux2ujo	423	9	cells	cell	NNS
cord-261028-sxux2ujo	423	10	by	by	IN
cord-261028-sxux2ujo	423	11	promoting	promote	VBG
cord-261028-sxux2ujo	423	12	differentiation	differentiation	NN
cord-261028-sxux2ujo	423	13	of	of	IN
cord-261028-sxux2ujo	423	14	Gr-1(+	gr-1(+	CD
cord-261028-sxux2ujo	423	15	)	)	-RRB-
cord-261028-sxux2ujo	424	1	conventional	conventional	JJ
cord-261028-sxux2ujo	424	2	dendritic	dendritic	JJ
cord-261028-sxux2ujo	424	3	cells	cell	NNS
cord-261028-sxux2ujo	424	4	through	through	IN
cord-261028-sxux2ujo	424	5	IL-6	IL-6	NNP
cord-261028-sxux2ujo	424	6	A	a	DT
cord-261028-sxux2ujo	424	7	critical	critical	JJ
cord-261028-sxux2ujo	424	8	function	function	NN
cord-261028-sxux2ujo	424	9	for	for	IN
cord-261028-sxux2ujo	424	10	type	type	NN
cord-261028-sxux2ujo	425	1	I	-PRON-	PRP
cord-261028-sxux2ujo	425	2	interferons	interferon	NNS
cord-261028-sxux2ujo	425	3	in	in	IN
cord-261028-sxux2ujo	425	4	cancer	cancer	NN
cord-261028-sxux2ujo	425	5	immunoediting	immunoediting	NNP
cord-261028-sxux2ujo	426	1	Interferon	interferon	NN
cord-261028-sxux2ujo	426	2	-	-	HYPH
cord-261028-sxux2ujo	426	3	gamma	gamma	NN
cord-261028-sxux2ujo	426	4	and	and	CC
cord-261028-sxux2ujo	426	5	cancer	cancer	NN
cord-261028-sxux2ujo	426	6	immunoediting	immunoediting	NNP
cord-261028-sxux2ujo	426	7	Toll	Toll	NNP
cord-261028-sxux2ujo	426	8	-	-	HYPH
cord-261028-sxux2ujo	426	9	like	like	JJ
cord-261028-sxux2ujo	426	10	receptor	receptor	NN
cord-261028-sxux2ujo	426	11	expression	expression	NN
cord-261028-sxux2ujo	426	12	in	in	IN
cord-261028-sxux2ujo	426	13	murine	murine	JJ
cord-261028-sxux2ujo	426	14	DC	DC	NNP
cord-261028-sxux2ujo	426	15	subsets	subset	NNS
cord-261028-sxux2ujo	426	16	:	:	:
cord-261028-sxux2ujo	426	17	lack	lack	NN
cord-261028-sxux2ujo	426	18	of	of	IN
cord-261028-sxux2ujo	426	19	TLR7	TLR7	NNP
cord-261028-sxux2ujo	426	20	expression	expression	NN
cord-261028-sxux2ujo	426	21	by	by	IN
cord-261028-sxux2ujo	426	22	CD8	CD8	NNP
cord-261028-sxux2ujo	426	23	alpha+	alpha+	NNP
cord-261028-sxux2ujo	426	24	DC	DC	NNP
cord-261028-sxux2ujo	426	25	correlates	correlate	VBZ
cord-261028-sxux2ujo	426	26	with	with	IN
cord-261028-sxux2ujo	426	27	unresponsiveness	unresponsiveness	NN
cord-261028-sxux2ujo	426	28	to	to	IN
cord-261028-sxux2ujo	426	29	imidazoquinolines	imidazoquinolines	NNP
cord-261028-sxux2ujo	426	30	Regulation	Regulation	NNP
cord-261028-sxux2ujo	426	31	of	of	IN
cord-261028-sxux2ujo	426	32	the	the	DT
cord-261028-sxux2ujo	426	33	antimicrobial	antimicrobial	JJ
cord-261028-sxux2ujo	426	34	response	response	NN
cord-261028-sxux2ujo	426	35	by	by	IN
cord-261028-sxux2ujo	426	36	NLR	NLR	NNP
cord-261028-sxux2ujo	426	37	proteins	protein	NNS
cord-261028-sxux2ujo	427	1	The	the	DT
cord-261028-sxux2ujo	427	2	dynamics	dynamic	NNS
cord-261028-sxux2ujo	427	3	of	of	IN
cord-261028-sxux2ujo	427	4	apoptotic	apoptotic	JJ
cord-261028-sxux2ujo	427	5	cell	cell	NN
cord-261028-sxux2ujo	427	6	clearance	clearance	NN
cord-261028-sxux2ujo	427	7	Tumor	Tumor	NNP
cord-261028-sxux2ujo	427	8	's	's	POS
cord-261028-sxux2ujo	427	9	other	other	JJ
cord-261028-sxux2ujo	427	10	immune	immune	JJ
cord-261028-sxux2ujo	427	11	targets	target	NNS
cord-261028-sxux2ujo	427	12	:	:	:
cord-261028-sxux2ujo	427	13	dendritic	dendritic	JJ
cord-261028-sxux2ujo	427	14	cells	cell	NNS
cord-261028-sxux2ujo	427	15	Long	long	RB
cord-261028-sxux2ujo	427	16	-	-	HYPH
cord-261028-sxux2ujo	427	17	lasting	last	VBG
cord-261028-sxux2ujo	427	18	crosspresentation	crosspresentation	NN
cord-261028-sxux2ujo	427	19	of	of	IN
cord-261028-sxux2ujo	427	20	tumor	tumor	NN
cord-261028-sxux2ujo	427	21	antigen	antigen	NN
cord-261028-sxux2ujo	427	22	in	in	IN
cord-261028-sxux2ujo	427	23	human	human	JJ
cord-261028-sxux2ujo	427	24	DC	DC	NNP
cord-261028-sxux2ujo	427	25	Ablative	Ablative	NNP
cord-261028-sxux2ujo	427	26	tumor	tumor	NN
cord-261028-sxux2ujo	427	27	radiation	radiation	NN
cord-261028-sxux2ujo	427	28	can	can	MD
cord-261028-sxux2ujo	427	29	change	change	VB
cord-261028-sxux2ujo	427	30	the	the	DT
cord-261028-sxux2ujo	427	31	tumor	tumor	NN
cord-261028-sxux2ujo	427	32	immune	immune	JJ
cord-261028-sxux2ujo	427	33	cell	cell	NN
cord-261028-sxux2ujo	427	34	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	427	35	to	to	TO
cord-261028-sxux2ujo	427	36	induce	induce	VB
cord-261028-sxux2ujo	427	37	durable	durable	JJ
cord-261028-sxux2ujo	427	38	complete	complete	JJ
cord-261028-sxux2ujo	427	39	remissions	remission	NNS
cord-261028-sxux2ujo	427	40	STING	sting	VB
cord-261028-sxux2ujo	427	41	agonist	agonist	NN
cord-261028-sxux2ujo	427	42	formulated	formulate	VBD
cord-261028-sxux2ujo	427	43	cancer	cancer	NN
cord-261028-sxux2ujo	427	44	vaccines	vaccine	NNS
cord-261028-sxux2ujo	427	45	can	can	MD
cord-261028-sxux2ujo	427	46	cure	cure	VB
cord-261028-sxux2ujo	427	47	established	establish	VBN
cord-261028-sxux2ujo	427	48	tumors	tumor	NNS
cord-261028-sxux2ujo	427	49	resistant	resistant	JJ
cord-261028-sxux2ujo	427	50	to	to	IN
cord-261028-sxux2ujo	427	51	PD-1	PD-1	NNP
cord-261028-sxux2ujo	427	52	blockade	blockade	NN
cord-261028-sxux2ujo	427	53	Host	host	NN
cord-261028-sxux2ujo	427	54	type	type	NN
cord-261028-sxux2ujo	428	1	I	-PRON-	PRP
cord-261028-sxux2ujo	428	2	IFN	IFN	NNP
cord-261028-sxux2ujo	428	3	signals	signal	NNS
cord-261028-sxux2ujo	428	4	are	be	VBP
cord-261028-sxux2ujo	428	5	required	require	VBN
cord-261028-sxux2ujo	428	6	for	for	IN
cord-261028-sxux2ujo	428	7	antitumor	antitumor	JJ
cord-261028-sxux2ujo	428	8	CD8	CD8	NNP
cord-261028-sxux2ujo	428	9	+	+	CC
cord-261028-sxux2ujo	428	10	T	T	NNP
cord-261028-sxux2ujo	428	11	cell	cell	NN
cord-261028-sxux2ujo	428	12	responses	response	NNS
cord-261028-sxux2ujo	428	13	through	through	IN
cord-261028-sxux2ujo	428	14	CD8{alpha}+	CD8{alpha}+	NNP
cord-261028-sxux2ujo	428	15	dendritic	dendritic	JJ
cord-261028-sxux2ujo	428	16	cells	cell	NNS
cord-261028-sxux2ujo	428	17	Structure	structure	NN
cord-261028-sxux2ujo	428	18	-	-	HYPH
cord-261028-sxux2ujo	428	19	function	function	NN
cord-261028-sxux2ujo	428	20	analysis	analysis	NN
cord-261028-sxux2ujo	428	21	of	of	IN
cord-261028-sxux2ujo	428	22	STING	sting	NN
cord-261028-sxux2ujo	428	23	activation	activation	NN
cord-261028-sxux2ujo	428	24	by	by	IN
cord-261028-sxux2ujo	428	25	c[G(2',5')pA(3',5	c[G(2',5')pA(3',5	NNP
cord-261028-sxux2ujo	428	26	'	'	''
cord-261028-sxux2ujo	428	27	)	)	-RRB-
cord-261028-sxux2ujo	428	28	p	p	NN
cord-261028-sxux2ujo	428	29	]	]	-RRB-
cord-261028-sxux2ujo	428	30	and	and	CC
cord-261028-sxux2ujo	428	31	targeting	target	VBG
cord-261028-sxux2ujo	428	32	by	by	IN
cord-261028-sxux2ujo	428	33	antiviral	antiviral	JJ
cord-261028-sxux2ujo	428	34	DMXAA	DMXAA	NNP
cord-261028-sxux2ujo	428	35	Local	Local	NNP
cord-261028-sxux2ujo	428	36	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	428	37	and	and	CC
cord-261028-sxux2ujo	428	38	granulocyte	granulocyte	NN
cord-261028-sxux2ujo	428	39	-	-	HYPH
cord-261028-sxux2ujo	428	40	macrophage	macrophage	NN
cord-261028-sxux2ujo	428	41	colony	colony	NN
cord-261028-sxux2ujo	428	42	-	-	HYPH
cord-261028-sxux2ujo	428	43	stimulating	stimulate	VBG
cord-261028-sxux2ujo	428	44	factor	factor	NN
cord-261028-sxux2ujo	428	45	to	to	TO
cord-261028-sxux2ujo	428	46	generate	generate	VB
cord-261028-sxux2ujo	428	47	abscopal	abscopal	JJ
cord-261028-sxux2ujo	428	48	responses	response	NNS
cord-261028-sxux2ujo	428	49	in	in	IN
cord-261028-sxux2ujo	428	50	patients	patient	NNS
cord-261028-sxux2ujo	428	51	with	with	IN
cord-261028-sxux2ujo	428	52	metastatic	metastatic	JJ
cord-261028-sxux2ujo	428	53	solid	solid	JJ
cord-261028-sxux2ujo	428	54	tumours	tumour	NNS
cord-261028-sxux2ujo	428	55	:	:	:
cord-261028-sxux2ujo	428	56	a	a	DT
cord-261028-sxux2ujo	428	57	proof	proof	NN
cord-261028-sxux2ujo	428	58	-	-	HYPH
cord-261028-sxux2ujo	428	59	of	of	IN
cord-261028-sxux2ujo	428	60	-	-	HYPH
cord-261028-sxux2ujo	428	61	principle	principle	NN
cord-261028-sxux2ujo	428	62	trial	trial	NN
cord-261028-sxux2ujo	428	63	ERphagosome	ERphagosome	NNP
cord-261028-sxux2ujo	428	64	fusion	fusion	NN
cord-261028-sxux2ujo	428	65	defines	define	VBZ
cord-261028-sxux2ujo	428	66	an	an	DT
cord-261028-sxux2ujo	428	67	MHC	MHC	NNP
cord-261028-sxux2ujo	428	68	class	class	NN
cord-261028-sxux2ujo	428	69	I	-PRON-	PRP
cord-261028-sxux2ujo	428	70	cross	cross	VBP
cord-261028-sxux2ujo	428	71	-	-	JJ
cord-261028-sxux2ujo	428	72	presentation	presentation	JJ
cord-261028-sxux2ujo	428	73	compartment	compartment	NN
cord-261028-sxux2ujo	428	74	in	in	IN
cord-261028-sxux2ujo	428	75	dendritic	dendritic	JJ
cord-261028-sxux2ujo	428	76	cells	cell	NNS
cord-261028-sxux2ujo	429	1	Radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	429	2	promotes	promote	VBZ
cord-261028-sxux2ujo	429	3	tumor	tumor	NN
cord-261028-sxux2ujo	429	4	-	-	HYPH
cord-261028-sxux2ujo	429	5	specific	specific	JJ
cord-261028-sxux2ujo	429	6	effector	effector	NN
cord-261028-sxux2ujo	429	7	CD8	CD8	NNS
cord-261028-sxux2ujo	429	8	+	+	CC
cord-261028-sxux2ujo	429	9	T	t	NN
cord-261028-sxux2ujo	429	10	cells	cell	NNS
cord-261028-sxux2ujo	429	11	via	via	IN
cord-261028-sxux2ujo	429	12	dendritic	dendritic	JJ
cord-261028-sxux2ujo	429	13	cell	cell	NN
cord-261028-sxux2ujo	429	14	activation	activation	NN
cord-261028-sxux2ujo	429	15	IRF8	IRF8	NNP
cord-261028-sxux2ujo	429	16	mutations	mutation	NNS
cord-261028-sxux2ujo	429	17	and	and	CC
cord-261028-sxux2ujo	429	18	human	human	JJ
cord-261028-sxux2ujo	429	19	dendritic	dendritic	JJ
cord-261028-sxux2ujo	429	20	-	-	HYPH
cord-261028-sxux2ujo	429	21	cell	cell	NN
cord-261028-sxux2ujo	429	22	immunodeficiency	immunodeficiency	NN
cord-261028-sxux2ujo	429	23	Human	human	JJ
cord-261028-sxux2ujo	429	24	tissues	tissue	NNS
cord-261028-sxux2ujo	430	1	contain	contain	VBP
cord-261028-sxux2ujo	430	2	CD141(hi	CD141(hi	NNP
cord-261028-sxux2ujo	430	3	)	)	-RRB-
cord-261028-sxux2ujo	430	4	cross	cross	JJ
cord-261028-sxux2ujo	430	5	-	-	JJ
cord-261028-sxux2ujo	430	6	presenting	presenting	JJ
cord-261028-sxux2ujo	430	7	dendritic	dendritic	JJ
cord-261028-sxux2ujo	430	8	cells	cell	NNS
cord-261028-sxux2ujo	430	9	with	with	IN
cord-261028-sxux2ujo	430	10	functional	functional	JJ
cord-261028-sxux2ujo	430	11	homology	homology	NN
cord-261028-sxux2ujo	430	12	to	to	TO
cord-261028-sxux2ujo	430	13	mouse	mouse	VB
cord-261028-sxux2ujo	430	14	CD103(+	CD103(+	NNP
cord-261028-sxux2ujo	430	15	)	)	-RRB-
cord-261028-sxux2ujo	430	16	nonlymphoid	nonlymphoid	NNP
cord-261028-sxux2ujo	430	17	dendritic	dendritic	JJ
cord-261028-sxux2ujo	430	18	cells	cell	VBZ
cord-261028-sxux2ujo	430	19	Human	human	JJ
cord-261028-sxux2ujo	430	20	skin	skin	NN
cord-261028-sxux2ujo	430	21	dendritic	dendritic	NN
cord-261028-sxux2ujo	430	22	cells	cell	NNS
cord-261028-sxux2ujo	430	23	in	in	IN
cord-261028-sxux2ujo	430	24	health	health	NN
cord-261028-sxux2ujo	430	25	and	and	CC
cord-261028-sxux2ujo	430	26	disease	disease	NN
cord-261028-sxux2ujo	430	27	Chemokine	chemokine	JJ
cord-261028-sxux2ujo	430	28	expression	expression	NN
cord-261028-sxux2ujo	430	29	in	in	IN
cord-261028-sxux2ujo	430	30	melanoma	melanoma	NN
cord-261028-sxux2ujo	430	31	metastases	metastasis	NNS
cord-261028-sxux2ujo	430	32	associated	associate	VBN
cord-261028-sxux2ujo	430	33	with	with	IN
cord-261028-sxux2ujo	430	34	CD8	CD8	NNP
cord-261028-sxux2ujo	430	35	+	+	CC
cord-261028-sxux2ujo	430	36	T	T	NNP
cord-261028-sxux2ujo	430	37	-	-	HYPH
cord-261028-sxux2ujo	430	38	cell	cell	NN
cord-261028-sxux2ujo	430	39	recruitment	recruitment	NN
cord-261028-sxux2ujo	430	40	Dendritic	dendritic	JJ
cord-261028-sxux2ujo	430	41	cell	cell	NN
cord-261028-sxux2ujo	430	42	and	and	CC
cord-261028-sxux2ujo	430	43	macrophage	macrophage	NN
cord-261028-sxux2ujo	430	44	heterogeneity	heterogeneity	NN
cord-261028-sxux2ujo	430	45	in	in	IN
cord-261028-sxux2ujo	430	46	vivo	vivo	NN
cord-261028-sxux2ujo	431	1	CD207	cd207	NN
cord-261028-sxux2ujo	432	1	+	+	CC
cord-261028-sxux2ujo	433	1	CD103	CD103	NNP
cord-261028-sxux2ujo	433	2	+	+	CC
cord-261028-sxux2ujo	433	3	dermal	dermal	JJ
cord-261028-sxux2ujo	433	4	dendritic	dendritic	JJ
cord-261028-sxux2ujo	433	5	cells	cell	NNS
cord-261028-sxux2ujo	433	6	cross	cross	VBP
cord-261028-sxux2ujo	433	7	-	-	JJ
cord-261028-sxux2ujo	433	8	present	present	JJ
cord-261028-sxux2ujo	433	9	keratinocyte	keratinocyte	NN
cord-261028-sxux2ujo	433	10	-	-	HYPH
cord-261028-sxux2ujo	433	11	derived	derive	VBN
cord-261028-sxux2ujo	433	12	antigens	antigen	NNS
cord-261028-sxux2ujo	433	13	irrespective	irrespective	RB
cord-261028-sxux2ujo	433	14	of	of	IN
cord-261028-sxux2ujo	433	15	the	the	DT
cord-261028-sxux2ujo	433	16	presence	presence	NN
cord-261028-sxux2ujo	433	17	of	of	IN
cord-261028-sxux2ujo	433	18	Langerhans	Langerhans	NNP
cord-261028-sxux2ujo	433	19	cells	cell	NNS
cord-261028-sxux2ujo	433	20	Batf3	Batf3	NNP
cord-261028-sxux2ujo	433	21	deficiency	deficiency	NN
cord-261028-sxux2ujo	433	22	reveals	reveal	VBZ
cord-261028-sxux2ujo	433	23	a	a	DT
cord-261028-sxux2ujo	433	24	critical	critical	JJ
cord-261028-sxux2ujo	433	25	role	role	NN
cord-261028-sxux2ujo	433	26	for	for	IN
cord-261028-sxux2ujo	433	27	CD8alpha+	CD8alpha+	NNP
cord-261028-sxux2ujo	433	28	dendritic	dendritic	JJ
cord-261028-sxux2ujo	433	29	cells	cell	NNS
cord-261028-sxux2ujo	433	30	in	in	IN
cord-261028-sxux2ujo	433	31	cytotoxic	cytotoxic	JJ
cord-261028-sxux2ujo	433	32	T	t	NN
cord-261028-sxux2ujo	433	33	cell	cell	NN
cord-261028-sxux2ujo	433	34	immunity	immunity	NN
cord-261028-sxux2ujo	433	35	Antigen	Antigen	NNP
cord-261028-sxux2ujo	433	36	crosspresentation	crosspresentation	NN
cord-261028-sxux2ujo	433	37	by	by	IN
cord-261028-sxux2ujo	433	38	human	human	JJ
cord-261028-sxux2ujo	433	39	plasmacytoid	plasmacytoid	NNP
cord-261028-sxux2ujo	433	40	dendritic	dendritic	JJ
cord-261028-sxux2ujo	433	41	cells	cell	NNS
cord-261028-sxux2ujo	434	1	Phagosomes	Phagosomes	NNP
cord-261028-sxux2ujo	434	2	are	be	VBP
cord-261028-sxux2ujo	434	3	competent	competent	JJ
cord-261028-sxux2ujo	434	4	organelles	organelle	NNS
cord-261028-sxux2ujo	434	5	for	for	IN
cord-261028-sxux2ujo	434	6	antigen	antigen	NN
cord-261028-sxux2ujo	434	7	cross	cross	JJ
cord-261028-sxux2ujo	434	8	-	-	NN
cord-261028-sxux2ujo	434	9	presentation	presentation	NN
cord-261028-sxux2ujo	434	10	Cutting	cutting	NN
cord-261028-sxux2ujo	434	11	edge	edge	NN
cord-261028-sxux2ujo	434	12	:	:	:
cord-261028-sxux2ujo	435	1	DNA	dna	NN
cord-261028-sxux2ujo	435	2	sensing	sensing	NN
cord-261028-sxux2ujo	435	3	via	via	IN
cord-261028-sxux2ujo	435	4	the	the	DT
cord-261028-sxux2ujo	435	5	STING	sting	NN
cord-261028-sxux2ujo	435	6	adaptor	adaptor	NN
cord-261028-sxux2ujo	435	7	in	in	IN
cord-261028-sxux2ujo	435	8	myeloid	myeloid	JJ
cord-261028-sxux2ujo	435	9	dendritic	dendritic	JJ
cord-261028-sxux2ujo	435	10	cells	cell	NNS
cord-261028-sxux2ujo	435	11	induces	induce	VBZ
cord-261028-sxux2ujo	435	12	potent	potent	JJ
cord-261028-sxux2ujo	435	13	tolerogenic	tolerogenic	JJ
cord-261028-sxux2ujo	435	14	responses	response	NNS
cord-261028-sxux2ujo	436	1	Antigen	antigen	NN
cord-261028-sxux2ujo	436	2	presentation	presentation	NN
cord-261028-sxux2ujo	436	3	by	by	IN
cord-261028-sxux2ujo	436	4	Langerhans	Langerhans	NNP
cord-261028-sxux2ujo	436	5	cells	cell	NNS
cord-261028-sxux2ujo	436	6	STING	sting	NN
cord-261028-sxux2ujo	436	7	regulates	regulate	VBZ
cord-261028-sxux2ujo	436	8	intracellular	intracellular	JJ
cord-261028-sxux2ujo	436	9	DNA	dna	NN
cord-261028-sxux2ujo	436	10	-	-	HYPH
cord-261028-sxux2ujo	436	11	mediated	mediate	VBN
cord-261028-sxux2ujo	436	12	,	,	,
cord-261028-sxux2ujo	437	1	type	type	NN
cord-261028-sxux2ujo	438	1	I	-PRON-	PRP
cord-261028-sxux2ujo	438	2	interferondependent	interferondependent	VBP
cord-261028-sxux2ujo	438	3	innate	innate	JJ
cord-261028-sxux2ujo	438	4	immunity	immunity	NN
cord-261028-sxux2ujo	439	1	An	an	DT
cord-261028-sxux2ujo	439	2	immune	immune	JJ
cord-261028-sxux2ujo	439	3	-	-	HYPH
cord-261028-sxux2ujo	439	4	active	active	JJ
cord-261028-sxux2ujo	439	5	tumor	tumor	NN
cord-261028-sxux2ujo	439	6	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	439	7	favors	favor	VBZ
cord-261028-sxux2ujo	439	8	clinical	clinical	JJ
cord-261028-sxux2ujo	439	9	response	response	NN
cord-261028-sxux2ujo	439	10	to	to	IN
cord-261028-sxux2ujo	439	11	ipilimumab	ipilimumab	NNP
cord-261028-sxux2ujo	439	12	Cross	Cross	NNP
cord-261028-sxux2ujo	439	13	-	-	NN
cord-261028-sxux2ujo	439	14	presentation	presentation	NN
cord-261028-sxux2ujo	439	15	by	by	IN
cord-261028-sxux2ujo	439	16	dendritic	dendritic	JJ
cord-261028-sxux2ujo	439	17	cells	cell	NNS
cord-261028-sxux2ujo	440	1	Human	human	JJ
cord-261028-sxux2ujo	440	2	CD141	CD141	NNP
cord-261028-sxux2ujo	440	3	+	+	CC
cord-261028-sxux2ujo	441	1	(	(	-LRB-
cord-261028-sxux2ujo	441	2	BDCA-3)+	BDCA-3)+	NNP
cord-261028-sxux2ujo	441	3	dendritic	dendritic	JJ
cord-261028-sxux2ujo	441	4	cells	cell	NNS
cord-261028-sxux2ujo	441	5	(	(	-LRB-
cord-261028-sxux2ujo	441	6	DCs	DCs	NNP
cord-261028-sxux2ujo	441	7	)	)	-RRB-
cord-261028-sxux2ujo	441	8	represent	represent	VBP
cord-261028-sxux2ujo	441	9	a	a	DT
cord-261028-sxux2ujo	441	10	unique	unique	JJ
cord-261028-sxux2ujo	441	11	myeloid	myeloid	NN
cord-261028-sxux2ujo	441	12	DC	DC	NNP
cord-261028-sxux2ujo	441	13	subset	subset	NNP
cord-261028-sxux2ujo	441	14	that	that	IN
cord-261028-sxux2ujo	441	15	cross	cross	NN
cord-261028-sxux2ujo	441	16	-	-	JJ
cord-261028-sxux2ujo	441	17	presents	presents	JJ
cord-261028-sxux2ujo	441	18	necrotic	necrotic	JJ
cord-261028-sxux2ujo	441	19	cell	cell	NN
cord-261028-sxux2ujo	441	20	antigens	antigen	NNS
cord-261028-sxux2ujo	441	21	Deciphering	decipher	VBG
cord-261028-sxux2ujo	441	22	the	the	DT
cord-261028-sxux2ujo	441	23	message	message	NN
cord-261028-sxux2ujo	441	24	broadcast	broadcast	VBN
cord-261028-sxux2ujo	441	25	by	by	IN
cord-261028-sxux2ujo	441	26	tumor	tumor	NN
cord-261028-sxux2ujo	441	27	-	-	HYPH
cord-261028-sxux2ujo	441	28	infiltrating	infiltrate	VBG
cord-261028-sxux2ujo	441	29	dendritic	dendritic	JJ
cord-261028-sxux2ujo	441	30	cells	cell	NNS
cord-261028-sxux2ujo	441	31	Antigen	antigen	NN
cord-261028-sxux2ujo	441	32	-	-	HYPH
cord-261028-sxux2ujo	441	33	presenting	present	VBG
cord-261028-sxux2ujo	441	34	cells	cell	NNS
cord-261028-sxux2ujo	441	35	in	in	IN
cord-261028-sxux2ujo	441	36	the	the	DT
cord-261028-sxux2ujo	441	37	skin	skin	NN
cord-261028-sxux2ujo	442	1	The	the	DT
cord-261028-sxux2ujo	442	2	roles	role	NNS
cord-261028-sxux2ujo	442	3	of	of	IN
cord-261028-sxux2ujo	442	4	TLRs	tlr	NNS
cord-261028-sxux2ujo	442	5	,	,	,
cord-261028-sxux2ujo	442	6	RLRs	rlr	NNS
cord-261028-sxux2ujo	442	7	and	and	CC
cord-261028-sxux2ujo	442	8	NLRs	nlr	NNS
cord-261028-sxux2ujo	442	9	in	in	IN
cord-261028-sxux2ujo	442	10	pathogen	pathogen	NN
cord-261028-sxux2ujo	442	11	recognition	recognition	NN
cord-261028-sxux2ujo	442	12	Toll	Toll	NNP
cord-261028-sxux2ujo	442	13	-	-	HYPH
cord-261028-sxux2ujo	442	14	like	like	JJ
cord-261028-sxux2ujo	442	15	receptors	receptor	NNS
cord-261028-sxux2ujo	442	16	and	and	CC
cord-261028-sxux2ujo	442	17	their	-PRON-	PRP$
cord-261028-sxux2ujo	442	18	crosstalk	crosstalk	NN
cord-261028-sxux2ujo	442	19	with	with	IN
cord-261028-sxux2ujo	442	20	other	other	JJ
cord-261028-sxux2ujo	442	21	innate	innate	JJ
cord-261028-sxux2ujo	442	22	receptors	receptor	NNS
cord-261028-sxux2ujo	442	23	in	in	IN
cord-261028-sxux2ujo	442	24	infection	infection	NN
cord-261028-sxux2ujo	442	25	and	and	CC
cord-261028-sxux2ujo	442	26	immunity	immunity	NN
cord-261028-sxux2ujo	442	27	Tumors	tumor	NNS
cord-261028-sxux2ujo	442	28	promote	promote	VBP
cord-261028-sxux2ujo	442	29	altered	alter	VBN
cord-261028-sxux2ujo	442	30	maturation	maturation	NN
cord-261028-sxux2ujo	442	31	and	and	CC
cord-261028-sxux2ujo	442	32	early	early	JJ
cord-261028-sxux2ujo	442	33	apoptosis	apoptosis	NN
cord-261028-sxux2ujo	442	34	of	of	IN
cord-261028-sxux2ujo	442	35	monocyte	monocyte	NNP
cord-261028-sxux2ujo	442	36	-	-	HYPH
cord-261028-sxux2ujo	442	37	derived	derive	VBN
cord-261028-sxux2ujo	442	38	dendritic	dendritic	JJ
cord-261028-sxux2ujo	442	39	cells	cell	NNS
cord-261028-sxux2ujo	442	40	STING	sting	VB
cord-261028-sxux2ujo	442	41	-	-	HYPH
cord-261028-sxux2ujo	442	42	mediated	mediate	VBN
cord-261028-sxux2ujo	442	43	DNA	dna	NN
cord-261028-sxux2ujo	442	44	sensing	sensing	NN
cord-261028-sxux2ujo	442	45	promotes	promote	VBZ
cord-261028-sxux2ujo	442	46	antitumor	antitumor	JJ
cord-261028-sxux2ujo	442	47	and	and	CC
cord-261028-sxux2ujo	442	48	autoimmune	autoimmune	JJ
cord-261028-sxux2ujo	442	49	responses	response	NNS
cord-261028-sxux2ujo	442	50	to	to	IN
cord-261028-sxux2ujo	442	51	dying	die	VBG
cord-261028-sxux2ujo	442	52	cells	cell	NNS
cord-261028-sxux2ujo	442	53	Density	density	NN
cord-261028-sxux2ujo	442	54	of	of	IN
cord-261028-sxux2ujo	442	55	DC	DC	NNP
cord-261028-sxux2ujo	442	56	-	-	HYPH
cord-261028-sxux2ujo	442	57	LAMP(+	LAMP(+	NNP
cord-261028-sxux2ujo	443	1	)	)	-RRB-
cord-261028-sxux2ujo	443	2	mature	mature	VB
cord-261028-sxux2ujo	443	3	dendritic	dendritic	JJ
cord-261028-sxux2ujo	443	4	cells	cell	NNS
cord-261028-sxux2ujo	443	5	in	in	IN
cord-261028-sxux2ujo	443	6	combination	combination	NN
cord-261028-sxux2ujo	443	7	with	with	IN
cord-261028-sxux2ujo	443	8	activated	activate	VBN
cord-261028-sxux2ujo	443	9	T	t	NN
cord-261028-sxux2ujo	443	10	lymphocytes	lymphocyte	NNS
cord-261028-sxux2ujo	443	11	infiltrating	infiltrate	VBG
cord-261028-sxux2ujo	443	12	primary	primary	JJ
cord-261028-sxux2ujo	443	13	cutaneous	cutaneous	JJ
cord-261028-sxux2ujo	443	14	melanoma	melanoma	NN
cord-261028-sxux2ujo	443	15	is	be	VBZ
cord-261028-sxux2ujo	443	16	a	a	DT
cord-261028-sxux2ujo	443	17	strong	strong	JJ
cord-261028-sxux2ujo	443	18	independent	independent	JJ
cord-261028-sxux2ujo	443	19	prognostic	prognostic	JJ
cord-261028-sxux2ujo	443	20	factor	factor	NN
cord-261028-sxux2ujo	443	21	Dnase2a	Dnase2a	NNP
cord-261028-sxux2ujo	443	22	deficiency	deficiency	NN
cord-261028-sxux2ujo	443	23	uncovers	uncover	VBZ
cord-261028-sxux2ujo	443	24	lysosomal	lysosomal	JJ
cord-261028-sxux2ujo	443	25	clearance	clearance	NN
cord-261028-sxux2ujo	443	26	of	of	IN
cord-261028-sxux2ujo	443	27	damaged	damaged	JJ
cord-261028-sxux2ujo	443	28	nuclear	nuclear	JJ
cord-261028-sxux2ujo	443	29	DNA	dna	NN
cord-261028-sxux2ujo	443	30	via	via	IN
cord-261028-sxux2ujo	443	31	autophagy	autophagy	NN
cord-261028-sxux2ujo	443	32	Randomized	randomized	JJ
cord-261028-sxux2ujo	443	33	phase	phase	NN
cord-261028-sxux2ujo	443	34	III	iii	CD
cord-261028-sxux2ujo	443	35	placebo	placebo	NN
cord-261028-sxux2ujo	443	36	-	-	HYPH
cord-261028-sxux2ujo	443	37	controlled	control	VBN
cord-261028-sxux2ujo	443	38	trial	trial	NN
cord-261028-sxux2ujo	443	39	of	of	IN
cord-261028-sxux2ujo	443	40	carboplatin	carboplatin	NNS
cord-261028-sxux2ujo	443	41	and	and	CC
cord-261028-sxux2ujo	443	42	paclitaxel	paclitaxel	VBD
cord-261028-sxux2ujo	443	43	with	with	IN
cord-261028-sxux2ujo	443	44	or	or	CC
cord-261028-sxux2ujo	443	45	without	without	IN
cord-261028-sxux2ujo	443	46	the	the	DT
cord-261028-sxux2ujo	443	47	vascular	vascular	JJ
cord-261028-sxux2ujo	443	48	disrupting	disrupt	VBG
cord-261028-sxux2ujo	443	49	agent	agent	NN
cord-261028-sxux2ujo	443	50	vadimezan	vadimezan	NNP
cord-261028-sxux2ujo	443	51	(	(	-LRB-
cord-261028-sxux2ujo	443	52	ASA404	ASA404	NNP
cord-261028-sxux2ujo	443	53	)	)	-RRB-
cord-261028-sxux2ujo	443	54	in	in	IN
cord-261028-sxux2ujo	443	55	advanced	advanced	JJ
cord-261028-sxux2ujo	443	56	non	non	JJ
cord-261028-sxux2ujo	443	57	-	-	JJ
cord-261028-sxux2ujo	443	58	small	small	JJ
cord-261028-sxux2ujo	443	59	-	-	HYPH
cord-261028-sxux2ujo	443	60	cell	cell	NN
cord-261028-sxux2ujo	443	61	lung	lung	NN
cord-261028-sxux2ujo	443	62	cancer	cancer	NN
cord-261028-sxux2ujo	443	63	Therapeutic	therapeutic	JJ
cord-261028-sxux2ujo	443	64	effects	effect	NNS
cord-261028-sxux2ujo	443	65	of	of	IN
cord-261028-sxux2ujo	443	66	ablative	ablative	JJ
cord-261028-sxux2ujo	443	67	radiation	radiation	NN
cord-261028-sxux2ujo	443	68	on	on	IN
cord-261028-sxux2ujo	443	69	local	local	JJ
cord-261028-sxux2ujo	443	70	tumor	tumor	NN
cord-261028-sxux2ujo	443	71	require	require	VBP
cord-261028-sxux2ujo	443	72	CD8	CD8	NNP
cord-261028-sxux2ujo	443	73	+	+	CC
cord-261028-sxux2ujo	443	74	T	t	NN
cord-261028-sxux2ujo	443	75	cells	cell	NNS
cord-261028-sxux2ujo	443	76	:	:	:
cord-261028-sxux2ujo	443	77	changing	change	VBG
cord-261028-sxux2ujo	443	78	strategies	strategy	NNS
cord-261028-sxux2ujo	443	79	for	for	IN
cord-261028-sxux2ujo	443	80	cancer	cancer	NN
cord-261028-sxux2ujo	443	81	treatment	treatment	NN
cord-261028-sxux2ujo	443	82	STING	sting	NN
cord-261028-sxux2ujo	443	83	promotes	promote	VBZ
cord-261028-sxux2ujo	443	84	the	the	DT
cord-261028-sxux2ujo	443	85	growth	growth	NN
cord-261028-sxux2ujo	443	86	of	of	IN
cord-261028-sxux2ujo	443	87	tumors	tumor	NNS
cord-261028-sxux2ujo	443	88	characterized	characterize	VBN
cord-261028-sxux2ujo	443	89	by	by	IN
cord-261028-sxux2ujo	443	90	low	low	JJ
cord-261028-sxux2ujo	443	91	antigenicity	antigenicity	NN
cord-261028-sxux2ujo	443	92	via	via	IN
cord-261028-sxux2ujo	443	93	IDO	IDO	NNP
cord-261028-sxux2ujo	443	94	activation	activation	NN
cord-261028-sxux2ujo	443	95	Antitumor	Antitumor	NNP
cord-261028-sxux2ujo	443	96	activity	activity	NN
cord-261028-sxux2ujo	443	97	of	of	IN
cord-261028-sxux2ujo	443	98	cGAMP	cGAMP	NNP
cord-261028-sxux2ujo	444	1	via	via	IN
cord-261028-sxux2ujo	444	2	stimulation	stimulation	NN
cord-261028-sxux2ujo	444	3	of	of	IN
cord-261028-sxux2ujo	444	4	cGAS	cgas	JJ
cord-261028-sxux2ujo	444	5	-	-	HYPH
cord-261028-sxux2ujo	444	6	cGAMP	cgamp	JJ
cord-261028-sxux2ujo	444	7	-	-	HYPH
cord-261028-sxux2ujo	444	8	STING	sting	NN
cord-261028-sxux2ujo	444	9	-	-	HYPH
cord-261028-sxux2ujo	444	10	IRF3	IRF3	NNP
cord-261028-sxux2ujo	444	11	mediated	mediate	VBN
cord-261028-sxux2ujo	445	1	innate	innate	JJ
cord-261028-sxux2ujo	445	2	immune	immune	JJ
cord-261028-sxux2ujo	445	3	response	response	NN
cord-261028-sxux2ujo	445	4	Type	type	NN
cord-261028-sxux2ujo	446	1	I	-PRON-	PRP
cord-261028-sxux2ujo	446	2	interferons	interferon	NNS
cord-261028-sxux2ujo	446	3	induced	induce	VBN
cord-261028-sxux2ujo	446	4	by	by	IN
cord-261028-sxux2ujo	446	5	radiation	radiation	NN
cord-261028-sxux2ujo	446	6	therapy	therapy	NN
cord-261028-sxux2ujo	446	7	mediate	mediate	VBP
cord-261028-sxux2ujo	446	8	recruitment	recruitment	NN
cord-261028-sxux2ujo	446	9	and	and	CC
cord-261028-sxux2ujo	446	10	effector	effector	NN
cord-261028-sxux2ujo	446	11	function	function	NN
cord-261028-sxux2ujo	446	12	of	of	IN
cord-261028-sxux2ujo	446	13	CD8(+	cd8(+	CD
cord-261028-sxux2ujo	446	14	)	)	-RRB-
cord-261028-sxux2ujo	447	1	T	T	NNP
cord-261028-sxux2ujo	447	2	cells	cell	NNS
cord-261028-sxux2ujo	448	1	Origin	origin	NN
cord-261028-sxux2ujo	448	2	and	and	CC
cord-261028-sxux2ujo	448	3	development	development	NN
cord-261028-sxux2ujo	448	4	of	of	IN
cord-261028-sxux2ujo	448	5	dendritic	dendritic	JJ
cord-261028-sxux2ujo	448	6	cells	cell	NNS
cord-261028-sxux2ujo	449	1	CD47	CD47	NNP
cord-261028-sxux2ujo	449	2	blockade	blockade	NN
cord-261028-sxux2ujo	449	3	triggers	trigger	VBZ
cord-261028-sxux2ujo	449	4	T	T	NNP
cord-261028-sxux2ujo	449	5	cell	cell	NN
cord-261028-sxux2ujo	449	6	-	-	HYPH
cord-261028-sxux2ujo	449	7	mediated	mediate	VBN
cord-261028-sxux2ujo	449	8	destruction	destruction	NN
cord-261028-sxux2ujo	449	9	of	of	IN
cord-261028-sxux2ujo	449	10	immunogenic	immunogenic	JJ
cord-261028-sxux2ujo	449	11	tumors	tumor	NNS
cord-261028-sxux2ujo	449	12	Immune	immune	VBP
cord-261028-sxux2ujo	449	13	signaling	signal	VBG
cord-261028-sxux2ujo	449	14	by	by	IN
cord-261028-sxux2ujo	449	15	RIG	rig	NN
cord-261028-sxux2ujo	449	16	-	-	HYPH
cord-261028-sxux2ujo	449	17	I	i	NN
cord-261028-sxux2ujo	449	18	-	-	HYPH
cord-261028-sxux2ujo	449	19	like	like	JJ
cord-261028-sxux2ujo	449	20	receptors	receptor	NNS
cord-261028-sxux2ujo	449	21	Type	type	NN
cord-261028-sxux2ujo	449	22	I	-PRON-	PRP
cord-261028-sxux2ujo	449	23	IFNs	ifns	VBP
cord-261028-sxux2ujo	449	24	control	control	NN
cord-261028-sxux2ujo	449	25	antigen	antigen	NN
cord-261028-sxux2ujo	449	26	retention	retention	NN
cord-261028-sxux2ujo	449	27	and	and	CC
cord-261028-sxux2ujo	449	28	survival	survival	NN
cord-261028-sxux2ujo	449	29	of	of	IN
cord-261028-sxux2ujo	449	30	CD8alpha	CD8alpha	NNP
cord-261028-sxux2ujo	449	31	(	(	-LRB-
cord-261028-sxux2ujo	449	32	+	+	NNS
cord-261028-sxux2ujo	449	33	)	)	-RRB-
cord-261028-sxux2ujo	449	34	dendritic	dendritic	JJ
cord-261028-sxux2ujo	449	35	cells	cell	NNS
cord-261028-sxux2ujo	449	36	after	after	IN
cord-261028-sxux2ujo	449	37	uptake	uptake	NN
cord-261028-sxux2ujo	449	38	of	of	IN
cord-261028-sxux2ujo	449	39	tumor	tumor	NN
cord-261028-sxux2ujo	449	40	apoptotic	apoptotic	JJ
cord-261028-sxux2ujo	449	41	cells	cell	NNS
cord-261028-sxux2ujo	449	42	leading	lead	VBG
cord-261028-sxux2ujo	449	43	to	to	IN
cord-261028-sxux2ujo	449	44	cross	cross	JJ
cord-261028-sxux2ujo	449	45	-	-	JJ
cord-261028-sxux2ujo	449	46	priming	priming	JJ
cord-261028-sxux2ujo	449	47	Local	local	JJ
cord-261028-sxux2ujo	449	48	radiation	radiation	NN
cord-261028-sxux2ujo	449	49	therapy	therapy	NN
cord-261028-sxux2ujo	449	50	of	of	IN
cord-261028-sxux2ujo	449	51	B16	B16	NNP
cord-261028-sxux2ujo	449	52	melanoma	melanoma	NN
cord-261028-sxux2ujo	449	53	tumors	tumor	NNS
cord-261028-sxux2ujo	449	54	increases	increase	VBZ
cord-261028-sxux2ujo	449	55	the	the	DT
cord-261028-sxux2ujo	449	56	generation	generation	NN
cord-261028-sxux2ujo	449	57	of	of	IN
cord-261028-sxux2ujo	449	58	tumor	tumor	NN
cord-261028-sxux2ujo	449	59	antigen	antigen	NN
cord-261028-sxux2ujo	449	60	-	-	HYPH
cord-261028-sxux2ujo	449	61	specific	specific	JJ
cord-261028-sxux2ujo	449	62	effector	effector	NN
cord-261028-sxux2ujo	449	63	cells	cell	NNS
cord-261028-sxux2ujo	449	64	that	that	WDT
cord-261028-sxux2ujo	449	65	traffic	traffic	NN
cord-261028-sxux2ujo	449	66	to	to	IN
cord-261028-sxux2ujo	449	67	the	the	DT
cord-261028-sxux2ujo	449	68	tumor	tumor	NN
cord-261028-sxux2ujo	449	69	Immature	immature	JJ
cord-261028-sxux2ujo	449	70	,	,	,
cord-261028-sxux2ujo	449	71	semi	semi	JJ
cord-261028-sxux2ujo	449	72	-	-	JJ
cord-261028-sxux2ujo	449	73	mature	mature	JJ
cord-261028-sxux2ujo	449	74	and	and	CC
cord-261028-sxux2ujo	449	75	fully	fully	RB
cord-261028-sxux2ujo	449	76	mature	mature	JJ
cord-261028-sxux2ujo	449	77	dendritic	dendritic	JJ
cord-261028-sxux2ujo	449	78	cells	cell	NNS
cord-261028-sxux2ujo	449	79	:	:	:
cord-261028-sxux2ujo	450	1	which	which	WDT
cord-261028-sxux2ujo	450	2	signals	signal	NNS
cord-261028-sxux2ujo	450	3	induce	induce	VBP
cord-261028-sxux2ujo	450	4	tolerance	tolerance	NN
cord-261028-sxux2ujo	450	5	or	or	CC
cord-261028-sxux2ujo	450	6	immunity	immunity	NN
cord-261028-sxux2ujo	450	7	Tumor	tumor	NN
cord-261028-sxux2ujo	450	8	associated	associate	VBD
cord-261028-sxux2ujo	450	9	regulatory	regulatory	JJ
cord-261028-sxux2ujo	450	10	dendritic	dendritic	JJ
cord-261028-sxux2ujo	450	11	cells	cell	NNS
cord-261028-sxux2ujo	450	12	Dendritic	dendritic	JJ
cord-261028-sxux2ujo	450	13	cells	cell	NNS
cord-261028-sxux2ujo	450	14	in	in	IN
cord-261028-sxux2ujo	450	15	the	the	DT
cord-261028-sxux2ujo	450	16	cancer	cancer	NN
cord-261028-sxux2ujo	450	17	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	450	18	Do	do	VBP
cord-261028-sxux2ujo	450	19	not	not	RB
cord-261028-sxux2ujo	450	20	let	let	VB
cord-261028-sxux2ujo	450	21	death	death	NN
cord-261028-sxux2ujo	450	22	do	do	VB
cord-261028-sxux2ujo	450	23	us	-PRON-	PRP
cord-261028-sxux2ujo	450	24	part	part	NN
cord-261028-sxux2ujo	450	25	:	:	:
cord-261028-sxux2ujo	450	26	'	'	``
cord-261028-sxux2ujo	450	27	find	find	VB
cord-261028-sxux2ujo	450	28	-	-	HYPH
cord-261028-sxux2ujo	450	29	me	-PRON-	PRP
cord-261028-sxux2ujo	450	30	'	'	POS
cord-261028-sxux2ujo	450	31	signals	signal	NNS
cord-261028-sxux2ujo	450	32	in	in	IN
cord-261028-sxux2ujo	450	33	communication	communication	NN
cord-261028-sxux2ujo	450	34	between	between	IN
cord-261028-sxux2ujo	450	35	dying	die	VBG
cord-261028-sxux2ujo	450	36	cells	cell	NNS
cord-261028-sxux2ujo	450	37	and	and	CC
cord-261028-sxux2ujo	450	38	the	the	DT
cord-261028-sxux2ujo	450	39	phagocytes	phagocyte	NNS
cord-261028-sxux2ujo	450	40	The	the	DT
cord-261028-sxux2ujo	450	41	dendritic	dendritic	JJ
cord-261028-sxux2ujo	450	42	cell	cell	NN
cord-261028-sxux2ujo	450	43	lineage	lineage	NN
cord-261028-sxux2ujo	450	44	:	:	:
cord-261028-sxux2ujo	450	45	ontogeny	ontogeny	NN
cord-261028-sxux2ujo	450	46	and	and	CC
cord-261028-sxux2ujo	450	47	function	function	NN
cord-261028-sxux2ujo	450	48	of	of	IN
cord-261028-sxux2ujo	450	49	dendritic	dendritic	JJ
cord-261028-sxux2ujo	450	50	cells	cell	NNS
cord-261028-sxux2ujo	450	51	and	and	CC
cord-261028-sxux2ujo	450	52	their	-PRON-	PRP$
cord-261028-sxux2ujo	450	53	subsets	subset	NNS
cord-261028-sxux2ujo	450	54	in	in	IN
cord-261028-sxux2ujo	450	55	the	the	DT
cord-261028-sxux2ujo	450	56	steady	steady	JJ
cord-261028-sxux2ujo	450	57	state	state	NN
cord-261028-sxux2ujo	450	58	and	and	CC
cord-261028-sxux2ujo	450	59	the	the	DT
cord-261028-sxux2ujo	450	60	inflamed	inflamed	JJ
cord-261028-sxux2ujo	450	61	setting	set	VBG
cord-261028-sxux2ujo	450	62	Dendritic	dendritic	JJ
cord-261028-sxux2ujo	450	63	cell	cell	NN
cord-261028-sxux2ujo	450	64	development	development	NN
cord-261028-sxux2ujo	450	65	:	:	:
cord-261028-sxux2ujo	450	66	a	a	DT
cord-261028-sxux2ujo	450	67	choose	choose	VB
cord-261028-sxux2ujo	450	68	-	-	HYPH
cord-261028-sxux2ujo	450	69	your	-PRON-	PRP$
cord-261028-sxux2ujo	450	70	-	-	HYPH
cord-261028-sxux2ujo	450	71	own	own	JJ
cord-261028-sxux2ujo	450	72	-	-	HYPH
cord-261028-sxux2ujo	450	73	adventure	adventure	NN
cord-261028-sxux2ujo	450	74	story	story	NN
cord-261028-sxux2ujo	450	75	Transcriptional	Transcriptional	NNP
cord-261028-sxux2ujo	450	76	priming	priming	NN
cord-261028-sxux2ujo	450	77	of	of	IN
cord-261028-sxux2ujo	450	78	intrathymic	intrathymic	JJ
cord-261028-sxux2ujo	450	79	precursors	precursor	NNS
cord-261028-sxux2ujo	450	80	for	for	IN
cord-261028-sxux2ujo	450	81	dendritic	dendritic	JJ
cord-261028-sxux2ujo	450	82	cell	cell	NN
cord-261028-sxux2ujo	450	83	development	development	NN
cord-261028-sxux2ujo	450	84	STING	sting	NN
cord-261028-sxux2ujo	450	85	mediates	mediate	VBZ
cord-261028-sxux2ujo	450	86	neuronal	neuronal	JJ
cord-261028-sxux2ujo	450	87	innate	innate	JJ
cord-261028-sxux2ujo	450	88	immune	immune	JJ
cord-261028-sxux2ujo	450	89	response	response	NN
cord-261028-sxux2ujo	450	90	following	follow	VBG
cord-261028-sxux2ujo	450	91	Japanese	japanese	JJ
cord-261028-sxux2ujo	450	92	encephalitis	encephalitis	RB
cord-261028-sxux2ujo	450	93	virus	virus	NN
cord-261028-sxux2ujo	450	94	infection	infection	NN
cord-261028-sxux2ujo	450	95	Antigen	Antigen	NNP
cord-261028-sxux2ujo	450	96	cross	cross	NN
cord-261028-sxux2ujo	450	97	-	-	NN
cord-261028-sxux2ujo	450	98	presentation	presentation	NN
cord-261028-sxux2ujo	450	99	by	by	IN
cord-261028-sxux2ujo	450	100	dendritic	dendritic	JJ
cord-261028-sxux2ujo	450	101	cell	cell	NN
cord-261028-sxux2ujo	450	102	subsets	subset	NNS
cord-261028-sxux2ujo	450	103	:	:	:
cord-261028-sxux2ujo	450	104	one	one	CD
cord-261028-sxux2ujo	450	105	general	general	JJ
cord-261028-sxux2ujo	450	106	or	or	CC
cord-261028-sxux2ujo	450	107	all	all	DT
cord-261028-sxux2ujo	450	108	sergeants	sergeant	NNS
cord-261028-sxux2ujo	450	109	?	?	.
cord-261028-sxux2ujo	451	1	STING	STING	NNP
cord-261028-sxux2ujo	451	2	contributes	contribute	VBZ
cord-261028-sxux2ujo	451	3	to	to	TO
cord-261028-sxux2ujo	451	4	antiglioma	antiglioma	VB
cord-261028-sxux2ujo	451	5	immunity	immunity	NN
cord-261028-sxux2ujo	451	6	via	via	IN
cord-261028-sxux2ujo	451	7	triggering	trigger	VBG
cord-261028-sxux2ujo	451	8	type	type	NN
cord-261028-sxux2ujo	452	1	I	-PRON-	PRP
cord-261028-sxux2ujo	452	2	IFN	IFN	NNP
cord-261028-sxux2ujo	452	3	signals	signal	VBZ
cord-261028-sxux2ujo	452	4	in	in	IN
cord-261028-sxux2ujo	452	5	the	the	DT
cord-261028-sxux2ujo	452	6	tumor	tumor	NN
cord-261028-sxux2ujo	452	7	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	452	8	Protective	protective	JJ
cord-261028-sxux2ujo	452	9	role	role	NN
cord-261028-sxux2ujo	452	10	of	of	IN
cord-261028-sxux2ujo	452	11	STING	sting	NN
cord-261028-sxux2ujo	452	12	against	against	IN
cord-261028-sxux2ujo	452	13	gliomagenesis	gliomagenesis	NNP
cord-261028-sxux2ujo	452	14	:	:	:
cord-261028-sxux2ujo	452	15	rational	rational	JJ
cord-261028-sxux2ujo	452	16	use	use	NN
cord-261028-sxux2ujo	452	17	of	of	IN
cord-261028-sxux2ujo	452	18	STING	sting	NN
cord-261028-sxux2ujo	452	19	agonist	agonist	NN
cord-261028-sxux2ujo	452	20	in	in	IN
cord-261028-sxux2ujo	452	21	anti	anti	JJ
cord-261028-sxux2ujo	452	22	-	-	JJ
cord-261028-sxux2ujo	452	23	glioma	glioma	JJ
cord-261028-sxux2ujo	452	24	immunotherapy	immunotherapy	NN
cord-261028-sxux2ujo	452	25	.	.	.
cord-261028-sxux2ujo	453	1	Oncoimmunology	oncoimmunology	IN
cord-261028-sxux2ujo	453	2	4	4	CD
cord-261028-sxux2ujo	453	3	,	,	,
cord-261028-sxux2ujo	453	4	e999523	e999523	NNP
cord-261028-sxux2ujo	453	5	Myeloid	Myeloid	NNP
cord-261028-sxux2ujo	453	6	C	c	NN
cord-261028-sxux2ujo	453	7	-	-	HYPH
cord-261028-sxux2ujo	453	8	type	type	NN
cord-261028-sxux2ujo	453	9	lectin	lectin	NN
cord-261028-sxux2ujo	453	10	receptors	receptor	NNS
cord-261028-sxux2ujo	453	11	in	in	IN
cord-261028-sxux2ujo	453	12	pathogen	pathogen	NN
cord-261028-sxux2ujo	453	13	recognition	recognition	NN
cord-261028-sxux2ujo	453	14	and	and	CC
cord-261028-sxux2ujo	453	15	host	host	NN
cord-261028-sxux2ujo	453	16	defense	defense	NN
cord-261028-sxux2ujo	453	17	Microbial	microbial	JJ
cord-261028-sxux2ujo	453	18	sensing	sensing	NN
cord-261028-sxux2ujo	453	19	by	by	IN
cord-261028-sxux2ujo	453	20	Toll	toll	NN
cord-261028-sxux2ujo	453	21	-	-	HYPH
cord-261028-sxux2ujo	453	22	like	like	JJ
cord-261028-sxux2ujo	453	23	receptors	receptor	NNS
cord-261028-sxux2ujo	453	24	and	and	CC
cord-261028-sxux2ujo	453	25	intracellular	intracellular	JJ
cord-261028-sxux2ujo	453	26	nucleic	nucleic	JJ
cord-261028-sxux2ujo	453	27	acid	acid	NN
cord-261028-sxux2ujo	453	28	sensors	sensor	NNS
cord-261028-sxux2ujo	453	29	.	.	.
cord-261028-sxux2ujo	454	1	Cold	cold	JJ
cord-261028-sxux2ujo	454	2	Spring	Spring	NNP
cord-261028-sxux2ujo	454	3	Harbor	Harbor	NNP
cord-261028-sxux2ujo	454	4	Perspect	Perspect	NNP
cord-261028-sxux2ujo	454	5	Activation	Activation	NNP
cord-261028-sxux2ujo	454	6	of	of	IN
cord-261028-sxux2ujo	454	7	STING	sting	NN
cord-261028-sxux2ujo	454	8	-	-	HYPH
cord-261028-sxux2ujo	454	9	dependent	dependent	JJ
cord-261028-sxux2ujo	454	10	innate	innate	JJ
cord-261028-sxux2ujo	454	11	immune	immune	JJ
cord-261028-sxux2ujo	454	12	signaling	signaling	NN
cord-261028-sxux2ujo	454	13	by	by	IN
cord-261028-sxux2ujo	454	14	S	s	NN
cord-261028-sxux2ujo	454	15	-	-	HYPH
cord-261028-sxux2ujo	454	16	phase	phase	NN
cord-261028-sxux2ujo	454	17	-	-	HYPH
cord-261028-sxux2ujo	454	18	specific	specific	JJ
cord-261028-sxux2ujo	454	19	DNA	dna	NN
cord-261028-sxux2ujo	454	20	damage	damage	NN
cord-261028-sxux2ujo	454	21	in	in	IN
cord-261028-sxux2ujo	454	22	Breast	breast	NN
cord-261028-sxux2ujo	454	23	cancer	cancer	NN
cord-261028-sxux2ujo	454	24	Gangliosides	ganglioside	NNS
cord-261028-sxux2ujo	454	25	from	from	IN
cord-261028-sxux2ujo	454	26	human	human	JJ
cord-261028-sxux2ujo	454	27	melanoma	melanoma	NN
cord-261028-sxux2ujo	454	28	tumors	tumor	NNS
cord-261028-sxux2ujo	454	29	impair	impair	VBP
cord-261028-sxux2ujo	454	30	dendritic	dendritic	JJ
cord-261028-sxux2ujo	454	31	cell	cell	NN
cord-261028-sxux2ujo	454	32	differentiation	differentiation	NN
cord-261028-sxux2ujo	454	33	from	from	IN
cord-261028-sxux2ujo	454	34	monocytes	monocyte	NNS
cord-261028-sxux2ujo	454	35	and	and	CC
cord-261028-sxux2ujo	454	36	induce	induce	VB
cord-261028-sxux2ujo	454	37	their	-PRON-	PRP$
cord-261028-sxux2ujo	454	38	apoptosis	apoptosis	NN
cord-261028-sxux2ujo	454	39	Cytokine	cytokine	NN
cord-261028-sxux2ujo	454	40	-	-	HYPH
cord-261028-sxux2ujo	454	41	mediated	mediate	VBN
cord-261028-sxux2ujo	454	42	protection	protection	NN
cord-261028-sxux2ujo	454	43	of	of	IN
cord-261028-sxux2ujo	454	44	human	human	JJ
cord-261028-sxux2ujo	454	45	dendritic	dendritic	JJ
cord-261028-sxux2ujo	454	46	cells	cell	NNS
cord-261028-sxux2ujo	454	47	from	from	IN
cord-261028-sxux2ujo	454	48	prostate	prostate	NN
cord-261028-sxux2ujo	454	49	cancer	cancer	NN
cord-261028-sxux2ujo	454	50	-	-	HYPH
cord-261028-sxux2ujo	454	51	induced	induce	VBN
cord-261028-sxux2ujo	454	52	apoptosis	apoptosis	NN
cord-261028-sxux2ujo	454	53	is	be	VBZ
cord-261028-sxux2ujo	454	54	regulated	regulate	VBN
cord-261028-sxux2ujo	454	55	by	by	IN
cord-261028-sxux2ujo	454	56	the	the	DT
cord-261028-sxux2ujo	454	57	Bcl-2	Bcl-2	NNP
cord-261028-sxux2ujo	454	58	family	family	NN
cord-261028-sxux2ujo	454	59	of	of	IN
cord-261028-sxux2ujo	454	60	proteins	protein	NNS
cord-261028-sxux2ujo	454	61	Characterization	Characterization	NNP
cord-261028-sxux2ujo	454	62	of	of	IN
cord-261028-sxux2ujo	454	63	human	human	JJ
cord-261028-sxux2ujo	454	64	DNGR-1	dngr-1	NN
cord-261028-sxux2ujo	454	65	+	+	CC
cord-261028-sxux2ujo	454	66	BDCA3	bdca3	NN
cord-261028-sxux2ujo	454	67	+	+	CC
cord-261028-sxux2ujo	454	68	leukocytes	leukocyte	NNS
cord-261028-sxux2ujo	454	69	as	as	IN
cord-261028-sxux2ujo	454	70	putative	putative	JJ
cord-261028-sxux2ujo	454	71	equivalents	equivalent	NNS
cord-261028-sxux2ujo	454	72	of	of	IN
cord-261028-sxux2ujo	454	73	mouse	mouse	NN
cord-261028-sxux2ujo	454	74	CD8alpha+	CD8alpha+	NNP
cord-261028-sxux2ujo	454	75	dendritic	dendritic	JJ
cord-261028-sxux2ujo	454	76	cells	cell	NNS
cord-261028-sxux2ujo	454	77	DNGR-1	dngr-1	VBP
cord-261028-sxux2ujo	454	78	is	be	VBZ
cord-261028-sxux2ujo	454	79	a	a	DT
cord-261028-sxux2ujo	454	80	specific	specific	JJ
cord-261028-sxux2ujo	454	81	and	and	CC
cord-261028-sxux2ujo	454	82	universal	universal	JJ
cord-261028-sxux2ujo	454	83	marker	marker	NN
cord-261028-sxux2ujo	454	84	of	of	IN
cord-261028-sxux2ujo	454	85	mouse	mouse	NN
cord-261028-sxux2ujo	454	86	and	and	CC
cord-261028-sxux2ujo	454	87	human	human	NN
cord-261028-sxux2ujo	454	88	Batf3-dependent	Batf3-dependent	NNP
cord-261028-sxux2ujo	454	89	dendritic	dendritic	JJ
cord-261028-sxux2ujo	454	90	cells	cell	NNS
cord-261028-sxux2ujo	454	91	in	in	IN
cord-261028-sxux2ujo	454	92	lymphoid	lymphoid	NN
cord-261028-sxux2ujo	454	93	and	and	CC
cord-261028-sxux2ujo	454	94	nonlymphoid	nonlymphoid	JJ
cord-261028-sxux2ujo	454	95	tissues	tissue	NNS
cord-261028-sxux2ujo	454	96	Dendritic	dendritic	JJ
cord-261028-sxux2ujo	454	97	cells	cell	NNS
cord-261028-sxux2ujo	454	98	and	and	CC
cord-261028-sxux2ujo	454	99	liver	liver	NN
cord-261028-sxux2ujo	454	100	fibrosis	fibrosis	NN
cord-261028-sxux2ujo	455	1	The	the	DT
cord-261028-sxux2ujo	455	2	scavenger	scavenger	NN
cord-261028-sxux2ujo	455	3	receptor	receptor	NN
cord-261028-sxux2ujo	455	4	SCARF1	SCARF1	NNP
cord-261028-sxux2ujo	455	5	mediates	mediate	VBZ
cord-261028-sxux2ujo	455	6	the	the	DT
cord-261028-sxux2ujo	455	7	clearance	clearance	NN
cord-261028-sxux2ujo	455	8	of	of	IN
cord-261028-sxux2ujo	455	9	apoptotic	apoptotic	JJ
cord-261028-sxux2ujo	455	10	cells	cell	NNS
cord-261028-sxux2ujo	455	11	and	and	CC
cord-261028-sxux2ujo	455	12	prevents	prevent	VBZ
cord-261028-sxux2ujo	455	13	autoimmunity	autoimmunity	NN
cord-261028-sxux2ujo	455	14	Migration	migration	NN
cord-261028-sxux2ujo	455	15	of	of	IN
cord-261028-sxux2ujo	455	16	dendritic	dendritic	JJ
cord-261028-sxux2ujo	455	17	cell	cell	NN
cord-261028-sxux2ujo	455	18	subsets	subset	NNS
cord-261028-sxux2ujo	455	19	and	and	CC
cord-261028-sxux2ujo	455	20	their	-PRON-	PRP$
cord-261028-sxux2ujo	455	21	precursors	precursor	NNS
cord-261028-sxux2ujo	455	22	The	the	DT
cord-261028-sxux2ujo	455	23	number	number	NN
cord-261028-sxux2ujo	455	24	of	of	IN
cord-261028-sxux2ujo	455	25	intratumoral	intratumoral	JJ
cord-261028-sxux2ujo	455	26	dendritic	dendritic	JJ
cord-261028-sxux2ujo	455	27	cells	cell	NNS
cord-261028-sxux2ujo	455	28	and	and	CC
cord-261028-sxux2ujo	455	29	zeta	zeta	JJ
cord-261028-sxux2ujo	455	30	-	-	HYPH
cord-261028-sxux2ujo	455	31	chain	chain	NN
cord-261028-sxux2ujo	455	32	expression	expression	NN
cord-261028-sxux2ujo	455	33	in	in	IN
cord-261028-sxux2ujo	455	34	T	t	NN
cord-261028-sxux2ujo	455	35	cells	cell	NNS
cord-261028-sxux2ujo	455	36	as	as	IN
cord-261028-sxux2ujo	455	37	prognostic	prognostic	JJ
cord-261028-sxux2ujo	455	38	and	and	CC
cord-261028-sxux2ujo	455	39	survival	survival	NN
cord-261028-sxux2ujo	455	40	biomarkers	biomarker	NNS
cord-261028-sxux2ujo	455	41	in	in	IN
cord-261028-sxux2ujo	455	42	patients	patient	NNS
cord-261028-sxux2ujo	455	43	with	with	IN
cord-261028-sxux2ujo	455	44	oral	oral	JJ
cord-261028-sxux2ujo	455	45	carcinoma	carcinoma	NN
cord-261028-sxux2ujo	455	46	Regulation	regulation	NN
cord-261028-sxux2ujo	455	47	of	of	IN
cord-261028-sxux2ujo	455	48	plasmacytoid	plasmacytoid	NNP
cord-261028-sxux2ujo	455	49	dendritic	dendritic	JJ
cord-261028-sxux2ujo	455	50	cell	cell	NN
cord-261028-sxux2ujo	455	51	development	development	NN
cord-261028-sxux2ujo	455	52	Dendritic	dendritic	JJ
cord-261028-sxux2ujo	455	53	cells	cell	NNS
cord-261028-sxux2ujo	455	54	and	and	CC
cord-261028-sxux2ujo	455	55	macrophages	macrophage	NNS
cord-261028-sxux2ujo	455	56	in	in	IN
cord-261028-sxux2ujo	455	57	the	the	DT
cord-261028-sxux2ujo	455	58	kidney	kidney	NN
cord-261028-sxux2ujo	455	59	:	:	:
cord-261028-sxux2ujo	455	60	a	a	DT
cord-261028-sxux2ujo	455	61	spectrum	spectrum	NN
cord-261028-sxux2ujo	455	62	of	of	IN
cord-261028-sxux2ujo	455	63	good	good	JJ
cord-261028-sxux2ujo	455	64	and	and	CC
cord-261028-sxux2ujo	455	65	evil	evil	JJ
cord-261028-sxux2ujo	455	66	Langerhans	Langerhans	NNP
cord-261028-sxux2ujo	455	67	cells	cell	NNS
cord-261028-sxux2ujo	455	68	and	and	CC
cord-261028-sxux2ujo	455	69	more	more	JJR
cord-261028-sxux2ujo	455	70	:	:	:
cord-261028-sxux2ujo	455	71	langerin	langerin	NNP
cord-261028-sxux2ujo	455	72	-	-	HYPH
cord-261028-sxux2ujo	455	73	expressing	express	VBG
cord-261028-sxux2ujo	455	74	dendritic	dendritic	JJ
cord-261028-sxux2ujo	455	75	cell	cell	NN
cord-261028-sxux2ujo	455	76	subsets	subset	NNS
cord-261028-sxux2ujo	455	77	in	in	IN
cord-261028-sxux2ujo	455	78	the	the	DT
cord-261028-sxux2ujo	455	79	skin	skin	NN
cord-261028-sxux2ujo	455	80	Functional	functional	JJ
cord-261028-sxux2ujo	455	81	characterization	characterization	NN
cord-261028-sxux2ujo	455	82	of	of	IN
cord-261028-sxux2ujo	455	83	the	the	DT
cord-261028-sxux2ujo	455	84	human	human	JJ
cord-261028-sxux2ujo	455	85	dendritic	dendritic	JJ
cord-261028-sxux2ujo	455	86	cell	cell	NN
cord-261028-sxux2ujo	455	87	immunodeficiency	immunodeficiency	NN
cord-261028-sxux2ujo	455	88	associated	associate	VBN
cord-261028-sxux2ujo	455	89	with	with	IN
cord-261028-sxux2ujo	455	90	the	the	DT
cord-261028-sxux2ujo	455	91	IRF8(K108E	IRF8(K108E	NNP
cord-261028-sxux2ujo	455	92	)	)	-RRB-
cord-261028-sxux2ujo	455	93	mutation	mutation	NN
cord-261028-sxux2ujo	455	94	Identification	identification	NN
cord-261028-sxux2ujo	455	95	of	of	IN
cord-261028-sxux2ujo	455	96	a	a	DT
cord-261028-sxux2ujo	455	97	dendritic	dendritic	JJ
cord-261028-sxux2ujo	455	98	cell	cell	NN
cord-261028-sxux2ujo	455	99	receptor	receptor	NN
cord-261028-sxux2ujo	455	100	that	that	WDT
cord-261028-sxux2ujo	455	101	couples	couple	NNS
cord-261028-sxux2ujo	455	102	sensing	sense	VBG
cord-261028-sxux2ujo	455	103	of	of	IN
cord-261028-sxux2ujo	455	104	necrosis	necrosis	NN
cord-261028-sxux2ujo	455	105	to	to	IN
cord-261028-sxux2ujo	455	106	immunity	immunity	NN
cord-261028-sxux2ujo	455	107	Spi	Spi	NNP
cord-261028-sxux2ujo	455	108	-	-	HYPH
cord-261028-sxux2ujo	455	109	B	B	NNP
cord-261028-sxux2ujo	455	110	is	be	VBZ
cord-261028-sxux2ujo	455	111	critical	critical	JJ
cord-261028-sxux2ujo	455	112	for	for	IN
cord-261028-sxux2ujo	455	113	plasmacytoid	plasmacytoid	NNP
cord-261028-sxux2ujo	455	114	dendritic	dendritic	JJ
cord-261028-sxux2ujo	455	115	cell	cell	NN
cord-261028-sxux2ujo	455	116	function	function	NN
cord-261028-sxux2ujo	455	117	and	and	CC
cord-261028-sxux2ujo	455	118	development	development	NN
cord-261028-sxux2ujo	455	119	Transcription	transcription	NN
cord-261028-sxux2ujo	455	120	factor	factor	NN
cord-261028-sxux2ujo	455	121	networks	network	NNS
cord-261028-sxux2ujo	455	122	in	in	IN
cord-261028-sxux2ujo	455	123	dendritic	dendritic	JJ
cord-261028-sxux2ujo	455	124	cell	cell	NN
cord-261028-sxux2ujo	455	125	development	development	NN
cord-261028-sxux2ujo	456	1	The	the	DT
cord-261028-sxux2ujo	456	2	ETS	ETS	NNP
cord-261028-sxux2ujo	456	3	transcription	transcription	NN
cord-261028-sxux2ujo	456	4	factor	factor	NN
cord-261028-sxux2ujo	456	5	Spi	Spi	NNP
cord-261028-sxux2ujo	456	6	-	-	HYPH
cord-261028-sxux2ujo	456	7	B	B	NNP
cord-261028-sxux2ujo	456	8	is	be	VBZ
cord-261028-sxux2ujo	456	9	required	require	VBN
cord-261028-sxux2ujo	456	10	for	for	IN
cord-261028-sxux2ujo	456	11	human	human	JJ
cord-261028-sxux2ujo	456	12	plasmacytoid	plasmacytoid	NNP
cord-261028-sxux2ujo	456	13	dendritic	dendritic	JJ
cord-261028-sxux2ujo	456	14	cell	cell	NN
cord-261028-sxux2ujo	456	15	development	development	NN
cord-261028-sxux2ujo	456	16	Inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	456	17	dendritic	dendritic	JJ
cord-261028-sxux2ujo	456	18	cells	cell	NNS
cord-261028-sxux2ujo	456	19	in	in	IN
cord-261028-sxux2ujo	456	20	mice	mouse	NNS
cord-261028-sxux2ujo	456	21	and	and	CC
cord-261028-sxux2ujo	456	22	humans	human	NNS
cord-261028-sxux2ujo	456	23	Differential	differential	JJ
cord-261028-sxux2ujo	456	24	expression	expression	NN
cord-261028-sxux2ujo	456	25	of	of	IN
cord-261028-sxux2ujo	456	26	pathogen	pathogen	NN
cord-261028-sxux2ujo	456	27	-	-	HYPH
cord-261028-sxux2ujo	456	28	recognition	recognition	NN
cord-261028-sxux2ujo	456	29	molecules	molecule	NNS
cord-261028-sxux2ujo	456	30	between	between	IN
cord-261028-sxux2ujo	456	31	dendritic	dendritic	JJ
cord-261028-sxux2ujo	456	32	cell	cell	NN
cord-261028-sxux2ujo	456	33	subsets	subset	NNS
cord-261028-sxux2ujo	456	34	revealed	reveal	VBN
cord-261028-sxux2ujo	456	35	by	by	IN
cord-261028-sxux2ujo	456	36	plasma	plasma	NN
cord-261028-sxux2ujo	456	37	membrane	membrane	NN
cord-261028-sxux2ujo	456	38	proteomic	proteomic	NN
cord-261028-sxux2ujo	456	39	analysis	analysis	NN
cord-261028-sxux2ujo	457	1	Radiation	radiation	NN
cord-261028-sxux2ujo	457	2	and	and	CC
cord-261028-sxux2ujo	457	3	checkpoint	checkpoint	NN
cord-261028-sxux2ujo	457	4	blockade	blockade	NN
cord-261028-sxux2ujo	457	5	immunotherapy	immunotherapy	NN
cord-261028-sxux2ujo	457	6	:	:	:
cord-261028-sxux2ujo	458	1	radiosensitisation	radiosensitisation	NN
cord-261028-sxux2ujo	458	2	and	and	CC
cord-261028-sxux2ujo	458	3	potential	potential	JJ
cord-261028-sxux2ujo	458	4	mechanisms	mechanism	NNS
cord-261028-sxux2ujo	458	5	of	of	IN
cord-261028-sxux2ujo	458	6	synergy	synergy	NN
cord-261028-sxux2ujo	458	7	Stereotactic	Stereotactic	NNP
cord-261028-sxux2ujo	458	8	radiation	radiation	NN
cord-261028-sxux2ujo	458	9	therapy	therapy	NN
cord-261028-sxux2ujo	458	10	augments	augment	VBZ
cord-261028-sxux2ujo	458	11	antigen	antigen	NN
cord-261028-sxux2ujo	458	12	-	-	HYPH
cord-261028-sxux2ujo	458	13	specific	specific	JJ
cord-261028-sxux2ujo	458	14	PD-1-mediated	pd-1-mediate	VBN
cord-261028-sxux2ujo	458	15	antitumor	antitumor	JJ
cord-261028-sxux2ujo	458	16	immune	immune	JJ
cord-261028-sxux2ujo	458	17	responses	response	NNS
cord-261028-sxux2ujo	458	18	via	via	IN
cord-261028-sxux2ujo	458	19	cross	cross	NN
cord-261028-sxux2ujo	458	20	-	-	NN
cord-261028-sxux2ujo	458	21	presentation	presentation	NN
cord-261028-sxux2ujo	458	22	of	of	IN
cord-261028-sxux2ujo	458	23	tumor	tumor	NN
cord-261028-sxux2ujo	458	24	antigen	antigen	NN
cord-261028-sxux2ujo	458	25	Virus	virus	NN
cord-261028-sxux2ujo	458	26	-	-	HYPH
cord-261028-sxux2ujo	458	27	induced	induce	VBN
cord-261028-sxux2ujo	458	28	type	type	NN
cord-261028-sxux2ujo	459	1	I	-PRON-	PRP
cord-261028-sxux2ujo	459	2	IFN	IFN	NNP
cord-261028-sxux2ujo	459	3	stimulates	stimulate	VBZ
cord-261028-sxux2ujo	459	4	generation	generation	NN
cord-261028-sxux2ujo	459	5	of	of	IN
cord-261028-sxux2ujo	459	6	immunoproteasomes	immunoproteasome	NNS
cord-261028-sxux2ujo	459	7	at	at	IN
cord-261028-sxux2ujo	459	8	the	the	DT
cord-261028-sxux2ujo	459	9	site	site	NN
cord-261028-sxux2ujo	459	10	of	of	IN
cord-261028-sxux2ujo	459	11	infection	infection	NN
cord-261028-sxux2ujo	459	12	Proteasome	Proteasome	NNP
cord-261028-sxux2ujo	459	13	activator	activator	NN
cord-261028-sxux2ujo	459	14	and	and	CC
cord-261028-sxux2ujo	459	15	antigen	antigen	NN
cord-261028-sxux2ujo	459	16	-	-	HYPH
cord-261028-sxux2ujo	459	17	processing	processing	NN
cord-261028-sxux2ujo	459	18	aminopeptidases	aminopeptidase	NNS
cord-261028-sxux2ujo	459	19	are	be	VBP
cord-261028-sxux2ujo	459	20	regulated	regulate	VBN
cord-261028-sxux2ujo	459	21	by	by	IN
cord-261028-sxux2ujo	459	22	virus	virus	NN
cord-261028-sxux2ujo	459	23	-	-	HYPH
cord-261028-sxux2ujo	459	24	induced	induce	VBN
cord-261028-sxux2ujo	459	25	type	type	NN
cord-261028-sxux2ujo	459	26	I	-PRON-	PRP
cord-261028-sxux2ujo	459	27	interferon	interferon	VBD
cord-261028-sxux2ujo	459	28	in	in	IN
cord-261028-sxux2ujo	459	29	the	the	DT
cord-261028-sxux2ujo	459	30	hepatitis	hepatitis	NN
cord-261028-sxux2ujo	459	31	C	C	NNP
cord-261028-sxux2ujo	459	32	virus	virus	NN
cord-261028-sxux2ujo	459	33	-	-	HYPH
cord-261028-sxux2ujo	459	34	infected	infect	VBN
cord-261028-sxux2ujo	459	35	liver	liver	NN
cord-261028-sxux2ujo	460	1	The	the	DT
cord-261028-sxux2ujo	460	2	CD8	CD8	NNP
cord-261028-sxux2ujo	460	3	+	+	CC
cord-261028-sxux2ujo	460	4	dendritic	dendritic	JJ
cord-261028-sxux2ujo	460	5	cell	cell	NN
cord-261028-sxux2ujo	460	6	subset	subset	VBN
cord-261028-sxux2ujo	460	7	DEC-205	DEC-205	NNP
cord-261028-sxux2ujo	460	8	)	)	-RRB-
cord-261028-sxux2ujo	460	9	:	:	:
cord-261028-sxux2ujo	460	10	a	a	DT
cord-261028-sxux2ujo	460	11	recognition	recognition	NN
cord-261028-sxux2ujo	460	12	receptor	receptor	NN
cord-261028-sxux2ujo	460	13	for	for	IN
cord-261028-sxux2ujo	460	14	apoptotic	apoptotic	JJ
cord-261028-sxux2ujo	460	15	and	and	CC
cord-261028-sxux2ujo	460	16	necrotic	necrotic	JJ
cord-261028-sxux2ujo	460	17	self	self	NN
cord-261028-sxux2ujo	460	18	Cancer	cancer	NN
cord-261028-sxux2ujo	460	19	cell	cell	NN
cord-261028-sxux2ujo	460	20	-	-	HYPH
cord-261028-sxux2ujo	460	21	autonomous	autonomous	JJ
cord-261028-sxux2ujo	460	22	contribution	contribution	NN
cord-261028-sxux2ujo	460	23	of	of	IN
cord-261028-sxux2ujo	460	24	type	type	NN
cord-261028-sxux2ujo	461	1	I	-PRON-	PRP
cord-261028-sxux2ujo	461	2	interferon	interferon	RB
cord-261028-sxux2ujo	461	3	signaling	signal	VBG
cord-261028-sxux2ujo	461	4	to	to	IN
cord-261028-sxux2ujo	461	5	the	the	DT
cord-261028-sxux2ujo	461	6	efficacy	efficacy	NN
cord-261028-sxux2ujo	461	7	of	of	IN
cord-261028-sxux2ujo	461	8	chemotherapy	chemotherapy	NN
cord-261028-sxux2ujo	461	9	IFN	IFN	NNP
cord-261028-sxux2ujo	461	10	-	-	HYPH
cord-261028-sxux2ujo	461	11	alpha	alpha	NNP
cord-261028-sxux2ujo	462	1	enhances	enhance	VBZ
cord-261028-sxux2ujo	462	2	cross	cross	NN
cord-261028-sxux2ujo	462	3	-	-	NN
cord-261028-sxux2ujo	462	4	presentation	presentation	NN
cord-261028-sxux2ujo	462	5	in	in	IN
cord-261028-sxux2ujo	462	6	human	human	JJ
cord-261028-sxux2ujo	462	7	dendritic	dendritic	JJ
cord-261028-sxux2ujo	462	8	cells	cell	NNS
cord-261028-sxux2ujo	462	9	by	by	IN
cord-261028-sxux2ujo	462	10	modulating	modulate	VBG
cord-261028-sxux2ujo	462	11	antigen	antigen	NN
cord-261028-sxux2ujo	462	12	survival	survival	NN
cord-261028-sxux2ujo	462	13	,	,	,
cord-261028-sxux2ujo	462	14	endocytic	endocytic	JJ
cord-261028-sxux2ujo	462	15	routing	routing	NN
cord-261028-sxux2ujo	462	16	,	,	,
cord-261028-sxux2ujo	462	17	and	and	CC
cord-261028-sxux2ujo	462	18	processing	processing	NN
cord-261028-sxux2ujo	462	19	Features	feature	NNS
cord-261028-sxux2ujo	462	20	of	of	IN
cord-261028-sxux2ujo	462	21	the	the	DT
cord-261028-sxux2ujo	462	22	dendritic	dendritic	JJ
cord-261028-sxux2ujo	462	23	cell	cell	NN
cord-261028-sxux2ujo	462	24	lineage	lineage	NN
cord-261028-sxux2ujo	462	25	Inefficient	inefficient	JJ
cord-261028-sxux2ujo	462	26	presentation	presentation	NN
cord-261028-sxux2ujo	462	27	of	of	IN
cord-261028-sxux2ujo	462	28	tumor	tumor	NN
cord-261028-sxux2ujo	462	29	-	-	HYPH
cord-261028-sxux2ujo	462	30	derived	derive	VBN
cord-261028-sxux2ujo	462	31	antigen	antigen	NN
cord-261028-sxux2ujo	462	32	by	by	IN
cord-261028-sxux2ujo	462	33	tumor	tumor	NN
cord-261028-sxux2ujo	462	34	-	-	HYPH
cord-261028-sxux2ujo	462	35	infiltrating	infiltrate	VBG
cord-261028-sxux2ujo	462	36	dendritic	dendritic	JJ
cord-261028-sxux2ujo	462	37	cells	cell	NNS
cord-261028-sxux2ujo	463	1	An	an	DT
cord-261028-sxux2ujo	463	2	AXL	AXL	NNP
cord-261028-sxux2ujo	463	3	/	/	SYM
cord-261028-sxux2ujo	463	4	LRP-1	LRP-1	NNP
cord-261028-sxux2ujo	463	5	/	/	SYM
cord-261028-sxux2ujo	463	6	RANBP9	RANBP9	NNP
cord-261028-sxux2ujo	463	7	complex	complex	NN
cord-261028-sxux2ujo	463	8	mediates	mediate	VBZ
cord-261028-sxux2ujo	463	9	DC	DC	NNP
cord-261028-sxux2ujo	463	10	efferocytosis	efferocytosis	NN
cord-261028-sxux2ujo	463	11	and	and	CC
cord-261028-sxux2ujo	463	12	antigen	antigen	NN
cord-261028-sxux2ujo	463	13	cross	cross	JJ
cord-261028-sxux2ujo	463	14	-	-	NN
cord-261028-sxux2ujo	463	15	presentation	presentation	NN
cord-261028-sxux2ujo	464	1	in	in	IN
cord-261028-sxux2ujo	464	2	vivo	vivo	NNP
cord-261028-sxux2ujo	464	3	Coronavirus	Coronavirus	NNP
cord-261028-sxux2ujo	464	4	papain	papain	NN
cord-261028-sxux2ujo	464	5	-	-	HYPH
cord-261028-sxux2ujo	464	6	like	like	JJ
cord-261028-sxux2ujo	464	7	proteases	protease	NNS
cord-261028-sxux2ujo	464	8	negatively	negatively	RB
cord-261028-sxux2ujo	464	9	regulate	regulate	VBP
cord-261028-sxux2ujo	464	10	antiviral	antiviral	JJ
cord-261028-sxux2ujo	464	11	innate	innate	JJ
cord-261028-sxux2ujo	464	12	immune	immune	JJ
cord-261028-sxux2ujo	464	13	response	response	NN
cord-261028-sxux2ujo	464	14	through	through	IN
cord-261028-sxux2ujo	464	15	disruption	disruption	NN
cord-261028-sxux2ujo	464	16	of	of	IN
cord-261028-sxux2ujo	464	17	STING	sting	NN
cord-261028-sxux2ujo	464	18	-	-	HYPH
cord-261028-sxux2ujo	464	19	mediated	mediate	VBN
cord-261028-sxux2ujo	464	20	signaling	signaling	NN
cord-261028-sxux2ujo	465	1	Cross	cross	NN
cord-261028-sxux2ujo	465	2	-	-	NN
cord-261028-sxux2ujo	465	3	presentation	presentation	NN
cord-261028-sxux2ujo	465	4	of	of	IN
cord-261028-sxux2ujo	465	5	cell	cell	NN
cord-261028-sxux2ujo	465	6	-	-	HYPH
cord-261028-sxux2ujo	465	7	associated	associate	VBN
cord-261028-sxux2ujo	465	8	antigens	antigen	NNS
cord-261028-sxux2ujo	465	9	by	by	IN
cord-261028-sxux2ujo	465	10	mouse	mouse	NN
cord-261028-sxux2ujo	465	11	splenic	splenic	JJ
cord-261028-sxux2ujo	465	12	dendritic	dendritic	JJ
cord-261028-sxux2ujo	465	13	cell	cell	NN
cord-261028-sxux2ujo	465	14	populations	population	NNS
cord-261028-sxux2ujo	465	15	Type	type	NN
cord-261028-sxux2ujo	465	16	I	-PRON-	PRP
cord-261028-sxux2ujo	465	17	interferons	interferon	NNS
cord-261028-sxux2ujo	465	18	(	(	-LRB-
cord-261028-sxux2ujo	465	19	alpha	alpha	NN
cord-261028-sxux2ujo	465	20	/	/	SYM
cord-261028-sxux2ujo	465	21	beta	beta	NN
cord-261028-sxux2ujo	465	22	)	)	-RRB-
cord-261028-sxux2ujo	465	23	in	in	IN
cord-261028-sxux2ujo	465	24	immunity	immunity	NN
cord-261028-sxux2ujo	465	25	and	and	CC
cord-261028-sxux2ujo	465	26	autoimmunity	autoimmunity	NN
cord-261028-sxux2ujo	465	27	Safety	safety	NN
cord-261028-sxux2ujo	465	28	,	,	,
cord-261028-sxux2ujo	465	29	activity	activity	NN
cord-261028-sxux2ujo	465	30	,	,	,
cord-261028-sxux2ujo	465	31	and	and	CC
cord-261028-sxux2ujo	465	32	immune	immune	JJ
cord-261028-sxux2ujo	465	33	correlates	correlate	NNS
cord-261028-sxux2ujo	465	34	of	of	IN
cord-261028-sxux2ujo	465	35	anti	anti	JJ
cord-261028-sxux2ujo	465	36	-	-	JJ
cord-261028-sxux2ujo	465	37	PD-1	pd-1	JJ
cord-261028-sxux2ujo	465	38	antibody	antibody	NN
cord-261028-sxux2ujo	465	39	in	in	IN
cord-261028-sxux2ujo	465	40	cancer	cancer	NN
cord-261028-sxux2ujo	465	41	Tumor	tumor	NN
cord-261028-sxux2ujo	465	42	-	-	HYPH
cord-261028-sxux2ujo	465	43	in	in	IN
cord-261028-sxux2ujo	465	44	-	-	HYPH
cord-261028-sxux2ujo	465	45	filtrating	filtrate	VBG
cord-261028-sxux2ujo	465	46	dendritic	dendritic	JJ
cord-261028-sxux2ujo	465	47	cells	cell	NNS
cord-261028-sxux2ujo	465	48	in	in	IN
cord-261028-sxux2ujo	465	49	cancer	cancer	NN
cord-261028-sxux2ujo	465	50	pathogenesis	pathogenesis	NN
cord-261028-sxux2ujo	466	1	Predictive	predictive	JJ
cord-261028-sxux2ujo	466	2	gene	gene	NN
cord-261028-sxux2ujo	466	3	signature	signature	NN
cord-261028-sxux2ujo	466	4	in	in	IN
cord-261028-sxux2ujo	466	5	MAGE	MAGE	NNP
cord-261028-sxux2ujo	466	6	-	-	HYPH
cord-261028-sxux2ujo	466	7	A3	A3	NNP
cord-261028-sxux2ujo	466	8	antigen	antigen	NN
cord-261028-sxux2ujo	466	9	-	-	HYPH
cord-261028-sxux2ujo	466	10	specific	specific	JJ
cord-261028-sxux2ujo	466	11	cancer	cancer	NN
cord-261028-sxux2ujo	466	12	immunotherapy	immunotherapy	NN
cord-261028-sxux2ujo	466	13	DNA	dna	NN
cord-261028-sxux2ujo	466	14	exonuclease	exonuclease	NN
cord-261028-sxux2ujo	467	1	Trex1	Trex1	NNP
cord-261028-sxux2ujo	467	2	regulates	regulate	VBZ
cord-261028-sxux2ujo	468	1	radiotherapy	radiotherapy	NN
cord-261028-sxux2ujo	468	2	-	-	HYPH
cord-261028-sxux2ujo	468	3	induced	induce	VBN
cord-261028-sxux2ujo	468	4	tumour	tumour	NN
cord-261028-sxux2ujo	468	5	immunogenicity	immunogenicity	NN
cord-261028-sxux2ujo	468	6	Antigen	antigen	NN
cord-261028-sxux2ujo	468	7	-	-	HYPH
cord-261028-sxux2ujo	468	8	presentation	presentation	NN
cord-261028-sxux2ujo	468	9	properties	property	NNS
cord-261028-sxux2ujo	468	10	of	of	IN
cord-261028-sxux2ujo	468	11	plasmacytoid	plasmacytoid	NNP
cord-261028-sxux2ujo	468	12	dendritic	dendritic	JJ
cord-261028-sxux2ujo	468	13	cells	cell	NNS
cord-261028-sxux2ujo	468	14	cGAS	cGAS	NNP
cord-261028-sxux2ujo	468	15	is	be	VBZ
cord-261028-sxux2ujo	468	16	essential	essential	JJ
cord-261028-sxux2ujo	468	17	for	for	IN
cord-261028-sxux2ujo	468	18	the	the	DT
cord-261028-sxux2ujo	468	19	antitumor	antitumor	JJ
cord-261028-sxux2ujo	468	20	effect	effect	NN
cord-261028-sxux2ujo	468	21	of	of	IN
cord-261028-sxux2ujo	468	22	immune	immune	JJ
cord-261028-sxux2ujo	468	23	checkpoint	checkpoint	NN
cord-261028-sxux2ujo	468	24	blockade	blockade	NN
cord-261028-sxux2ujo	468	25	Radiotherapy	Radiotherapy	NNP
cord-261028-sxux2ujo	468	26	and	and	CC
cord-261028-sxux2ujo	468	27	immunotherapy	immunotherapy	NN
cord-261028-sxux2ujo	468	28	:	:	:
cord-261028-sxux2ujo	468	29	a	a	DT
cord-261028-sxux2ujo	468	30	beneficial	beneficial	JJ
cord-261028-sxux2ujo	468	31	liaison	liaison	NN
cord-261028-sxux2ujo	468	32	?	?	.
cord-261028-sxux2ujo	469	1	Immunomorphological	Immunomorphological	NNP
cord-261028-sxux2ujo	469	2	and	and	CC
cord-261028-sxux2ujo	469	3	ultra	ultra	JJ
cord-261028-sxux2ujo	469	4	-	-	JJ
cord-261028-sxux2ujo	469	5	structural	structural	JJ
cord-261028-sxux2ujo	469	6	characterization	characterization	NN
cord-261028-sxux2ujo	469	7	of	of	IN
cord-261028-sxux2ujo	469	8	Langerhans	Langerhans	NNP
cord-261028-sxux2ujo	469	9	cells	cell	NNS
cord-261028-sxux2ujo	469	10	and	and	CC
cord-261028-sxux2ujo	469	11	a	a	DT
cord-261028-sxux2ujo	469	12	novel	novel	NN
cord-261028-sxux2ujo	469	13	,	,	,
cord-261028-sxux2ujo	469	14	inflammatory	inflammatory	JJ
cord-261028-sxux2ujo	469	15	dendritic	dendritic	JJ
cord-261028-sxux2ujo	469	16	epidermal	epidermal	JJ
cord-261028-sxux2ujo	469	17	cell	cell	NN
cord-261028-sxux2ujo	469	18	(	(	-LRB-
cord-261028-sxux2ujo	469	19	IDEC	IDEC	NNP
cord-261028-sxux2ujo	469	20	)	)	-RRB-
cord-261028-sxux2ujo	469	21	population	population	NN
cord-261028-sxux2ujo	469	22	in	in	IN
cord-261028-sxux2ujo	469	23	lesional	lesional	JJ
cord-261028-sxux2ujo	469	24	skin	skin	NN
cord-261028-sxux2ujo	469	25	of	of	IN
cord-261028-sxux2ujo	469	26	atopic	atopic	JJ
cord-261028-sxux2ujo	469	27	eczema	eczema	NN
cord-261028-sxux2ujo	469	28	STING	sting	NN
cord-261028-sxux2ujo	469	29	-	-	HYPH
cord-261028-sxux2ujo	469	30	dependent	dependent	JJ
cord-261028-sxux2ujo	469	31	cytosolic	cytosolic	JJ
cord-261028-sxux2ujo	469	32	DNA	dna	NN
cord-261028-sxux2ujo	469	33	sensing	sensing	NN
cord-261028-sxux2ujo	469	34	mediates	mediate	VBZ
cord-261028-sxux2ujo	469	35	innate	innate	JJ
cord-261028-sxux2ujo	469	36	immune	immune	JJ
cord-261028-sxux2ujo	469	37	recognition	recognition	NN
cord-261028-sxux2ujo	469	38	of	of	IN
cord-261028-sxux2ujo	469	39	immunogenic	immunogenic	JJ
cord-261028-sxux2ujo	469	40	tumors	tumor	NNS
cord-261028-sxux2ujo	470	1	The	the	DT
cord-261028-sxux2ujo	470	2	STING	sting	NN
cord-261028-sxux2ujo	470	3	pathway	pathway	NN
cord-261028-sxux2ujo	470	4	and	and	CC
cord-261028-sxux2ujo	470	5	the	the	DT
cord-261028-sxux2ujo	470	6	T	T	NNP
cord-261028-sxux2ujo	470	7	cell	cell	NN
cord-261028-sxux2ujo	470	8	-	-	HYPH
cord-261028-sxux2ujo	470	9	inflamed	inflame	VBN
cord-261028-sxux2ujo	470	10	tumor	tumor	NN
cord-261028-sxux2ujo	470	11	microenvironment	microenvironment	NN
cord-261028-sxux2ujo	470	12	Programming	programming	NN
cord-261028-sxux2ujo	470	13	for	for	IN
cord-261028-sxux2ujo	470	14	CD8	CD8	NNP
cord-261028-sxux2ujo	470	15	T	T	NNP
cord-261028-sxux2ujo	470	16	cell	cell	NN
cord-261028-sxux2ujo	470	17	memory	memory	NN
cord-261028-sxux2ujo	470	18	development	development	NN
cord-261028-sxux2ujo	470	19	requires	require	VBZ
cord-261028-sxux2ujo	470	20	IL-12	IL-12	NNP
cord-261028-sxux2ujo	470	21	or	or	CC
cord-261028-sxux2ujo	470	22	type	type	NN
cord-261028-sxux2ujo	471	1	I	-PRON-	PRP
cord-261028-sxux2ujo	471	2	IFN	IFN	NNP
cord-261028-sxux2ujo	471	3	Radiotherapy	Radiotherapy	NNP
cord-261028-sxux2ujo	471	4	-	-	HYPH
cord-261028-sxux2ujo	471	5	induced	induce	VBN
cord-261028-sxux2ujo	471	6	anti	anti	JJ
cord-261028-sxux2ujo	471	7	-	-	JJ
cord-261028-sxux2ujo	471	8	tumor	tumor	JJ
cord-261028-sxux2ujo	471	9	immunity	immunity	NN
cord-261028-sxux2ujo	471	10	contributes	contribute	VBZ
cord-261028-sxux2ujo	471	11	to	to	IN
cord-261028-sxux2ujo	471	12	the	the	DT
cord-261028-sxux2ujo	471	13	therapeutic	therapeutic	JJ
cord-261028-sxux2ujo	471	14	efficacy	efficacy	NN
cord-261028-sxux2ujo	471	15	of	of	IN
cord-261028-sxux2ujo	471	16	irradiation	irradiation	NN
cord-261028-sxux2ujo	471	17	and	and	CC
cord-261028-sxux2ujo	471	18	can	can	MD
cord-261028-sxux2ujo	471	19	be	be	VB
cord-261028-sxux2ujo	471	20	augmented	augment	VBN
cord-261028-sxux2ujo	471	21	by	by	IN
cord-261028-sxux2ujo	471	22	CTLA-4	CTLA-4	NNS
cord-261028-sxux2ujo	471	23	blockade	blockade	VBP
cord-261028-sxux2ujo	471	24	in	in	IN
cord-261028-sxux2ujo	471	25	a	a	DT
cord-261028-sxux2ujo	471	26	mouse	mouse	NN
cord-261028-sxux2ujo	471	27	model	model	NN
cord-261028-sxux2ujo	471	28	The	the	DT
cord-261028-sxux2ujo	471	29	dendritic	dendritic	JJ
cord-261028-sxux2ujo	471	30	cell	cell	NN
cord-261028-sxux2ujo	471	31	receptor	receptor	NN
cord-261028-sxux2ujo	471	32	DNGR-1	dngr-1	NN
cord-261028-sxux2ujo	471	33	controls	control	VBZ
cord-261028-sxux2ujo	471	34	endocytic	endocytic	JJ
cord-261028-sxux2ujo	471	35	handling	handling	NN
cord-261028-sxux2ujo	471	36	of	of	IN
cord-261028-sxux2ujo	471	37	necrotic	necrotic	JJ
cord-261028-sxux2ujo	471	38	cell	cell	NN
cord-261028-sxux2ujo	471	39	antigens	antigen	NNS
cord-261028-sxux2ujo	471	40	to	to	TO
cord-261028-sxux2ujo	471	41	favor	favor	VB
cord-261028-sxux2ujo	471	42	cross	cross	NN
cord-261028-sxux2ujo	471	43	-	-	JJ
cord-261028-sxux2ujo	471	44	priming	priming	NN
cord-261028-sxux2ujo	471	45	of	of	IN
cord-261028-sxux2ujo	471	46	CTLs	ctl	NNS
cord-261028-sxux2ujo	471	47	in	in	IN
cord-261028-sxux2ujo	471	48	virus	virus	NN
cord-261028-sxux2ujo	471	49	-	-	HYPH
cord-261028-sxux2ujo	471	50	infected	infect	VBN
cord-261028-sxux2ujo	471	51	mice	mouse	NNS
cord-261028-sxux2ujo	472	1	The	the	DT
cord-261028-sxux2ujo	472	2	dendritic	dendritic	JJ
cord-261028-sxux2ujo	472	3	cell	cell	NN
cord-261028-sxux2ujo	472	4	receptor	receptor	NN
cord-261028-sxux2ujo	472	5	Clec9A	Clec9A	NNP
cord-261028-sxux2ujo	472	6	binds	bind	VBZ
cord-261028-sxux2ujo	472	7	damaged	damage	VBN
cord-261028-sxux2ujo	472	8	cells	cell	NNS
cord-261028-sxux2ujo	472	9	via	via	IN
cord-261028-sxux2ujo	472	10	exposed	expose	VBN
cord-261028-sxux2ujo	472	11	actin	actin	NN
cord-261028-sxux2ujo	472	12	filaments	filament	NNS
cord-261028-sxux2ujo	472	13	Cutting	cut	VBG
cord-261028-sxux2ujo	472	14	edge	edge	NN
cord-261028-sxux2ujo	472	15	:	:	:
cord-261028-sxux2ujo	472	16	STING	sting	NN
cord-261028-sxux2ujo	472	17	mediates	mediate	VBZ
cord-261028-sxux2ujo	472	18	protection	protection	NN
cord-261028-sxux2ujo	472	19	against	against	IN
cord-261028-sxux2ujo	472	20	colorectal	colorectal	JJ
cord-261028-sxux2ujo	472	21	tumorigenesis	tumorigenesis	NN
cord-261028-sxux2ujo	472	22	by	by	IN
cord-261028-sxux2ujo	472	23	governing	govern	VBG
cord-261028-sxux2ujo	472	24	the	the	DT
cord-261028-sxux2ujo	472	25	magnitude	magnitude	NN
cord-261028-sxux2ujo	472	26	of	of	IN
cord-261028-sxux2ujo	472	27	intestinal	intestinal	JJ
cord-261028-sxux2ujo	472	28	inflammation	inflammation	NN