id	sid	tid	token	lemma	pos
cord-259748-x7dq1sy4	1	1	key	key	JJ
cord-259748-x7dq1sy4	1	2	:	:	:
cord-259748-x7dq1sy4	1	3	cord-259748-x7dq1sy4	cord-259748-x7dq1sy4	JJ
cord-259748-x7dq1sy4	1	4	authors	author	NNS
cord-259748-x7dq1sy4	1	5	:	:	:
cord-259748-x7dq1sy4	1	6	Wan	Wan	NNP
cord-259748-x7dq1sy4	1	7	,	,	,
cord-259748-x7dq1sy4	1	8	Dongshan	Dongshan	NNP
cord-259748-x7dq1sy4	1	9	;	;	:
cord-259748-x7dq1sy4	1	10	Jiang	Jiang	NNP
cord-259748-x7dq1sy4	1	11	,	,	,
cord-259748-x7dq1sy4	1	12	Wei	Wei	NNP
cord-259748-x7dq1sy4	1	13	;	;	:
cord-259748-x7dq1sy4	1	14	Hao	Hao	NNP
cord-259748-x7dq1sy4	1	15	,	,	,
cord-259748-x7dq1sy4	2	1	Junwei	Junwei	NNP
cord-259748-x7dq1sy4	2	2	title	title	NN
cord-259748-x7dq1sy4	2	3	:	:	:
cord-259748-x7dq1sy4	2	4	Research	research	NN
cord-259748-x7dq1sy4	2	5	Advances	advance	VBZ
cord-259748-x7dq1sy4	2	6	in	in	IN
cord-259748-x7dq1sy4	2	7	How	how	WRB
cord-259748-x7dq1sy4	2	8	the	the	DT
cord-259748-x7dq1sy4	2	9	cGAS	cgas	NN
cord-259748-x7dq1sy4	2	10	-	-	HYPH
cord-259748-x7dq1sy4	2	11	STING	STING	NNP
cord-259748-x7dq1sy4	2	12	Pathway	Pathway	NNP
cord-259748-x7dq1sy4	2	13	Controls	control	VBZ
cord-259748-x7dq1sy4	2	14	the	the	DT
cord-259748-x7dq1sy4	2	15	Cellular	Cellular	NNP
cord-259748-x7dq1sy4	2	16	Inflammatory	Inflammatory	NNP
cord-259748-x7dq1sy4	2	17	Response	Response	NNP
cord-259748-x7dq1sy4	2	18	date	date	NN
cord-259748-x7dq1sy4	2	19	:	:	:
cord-259748-x7dq1sy4	2	20	2020	2020	CD
cord-259748-x7dq1sy4	2	21	-	-	HYPH
cord-259748-x7dq1sy4	2	22	04	04	CD
cord-259748-x7dq1sy4	2	23	-	-	HYPH
cord-259748-x7dq1sy4	2	24	28	28	CD
cord-259748-x7dq1sy4	2	25	journal	journal	NN
cord-259748-x7dq1sy4	2	26	:	:	:
cord-259748-x7dq1sy4	3	1	Front	Front	NNP
cord-259748-x7dq1sy4	3	2	Immunol	Immunol	NNP
cord-259748-x7dq1sy4	3	3	DOI	DOI	NNP
cord-259748-x7dq1sy4	3	4	:	:	:
cord-259748-x7dq1sy4	3	5	10.3389	10.3389	CD
cord-259748-x7dq1sy4	3	6	/	/	SYM
cord-259748-x7dq1sy4	3	7	fimmu.2020.00615	fimmu.2020.00615	NN
cord-259748-x7dq1sy4	3	8	sha	sha	NN
cord-259748-x7dq1sy4	3	9	:	:	:
cord-259748-x7dq1sy4	3	10	5d44c15017651c74f2134ee0882062e8d7efb4b1	5d44c15017651c74f2134ee0882062e8d7efb4b1	CD
cord-259748-x7dq1sy4	3	11	doc_id	doc_id	CD
cord-259748-x7dq1sy4	3	12	:	:	:
cord-259748-x7dq1sy4	3	13	259748	259748	CD
cord-259748-x7dq1sy4	3	14	cord_uid	cord_uid	FW
cord-259748-x7dq1sy4	3	15	:	:	:
cord-259748-x7dq1sy4	4	1	x7dq1sy4	x7dq1sy4	ADD
cord-259748-x7dq1sy4	4	2	Double	double	RB
cord-259748-x7dq1sy4	4	3	-	-	HYPH
cord-259748-x7dq1sy4	4	4	stranded	strand	VBN
cord-259748-x7dq1sy4	4	5	DNA	dna	NN
cord-259748-x7dq1sy4	4	6	(	(	-LRB-
cord-259748-x7dq1sy4	4	7	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	4	8	)	)	-RRB-
cord-259748-x7dq1sy4	5	1	sensor	sensor	NNP
cord-259748-x7dq1sy4	5	2	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	5	3	-	-	HYPH
cord-259748-x7dq1sy4	5	4	GMP	GMP	NNP
cord-259748-x7dq1sy4	5	5	-	-	HYPH
cord-259748-x7dq1sy4	5	6	AMP	AMP	NNP
cord-259748-x7dq1sy4	5	7	synthase	synthase	NN
cord-259748-x7dq1sy4	5	8	(	(	-LRB-
cord-259748-x7dq1sy4	5	9	cGAS	cgas	NN
cord-259748-x7dq1sy4	5	10	)	)	-RRB-
cord-259748-x7dq1sy4	5	11	along	along	IN
cord-259748-x7dq1sy4	5	12	with	with	IN
cord-259748-x7dq1sy4	6	1	the	the	DT
cord-259748-x7dq1sy4	6	2	downstream	downstream	JJ
cord-259748-x7dq1sy4	6	3	stimulator	stimulator	NN
cord-259748-x7dq1sy4	6	4	of	of	IN
cord-259748-x7dq1sy4	6	5	interferon	interferon	NN
cord-259748-x7dq1sy4	6	6	genes	gene	NNS
cord-259748-x7dq1sy4	6	7	(	(	-LRB-
cord-259748-x7dq1sy4	6	8	STING	sting	NN
cord-259748-x7dq1sy4	6	9	)	)	-RRB-
cord-259748-x7dq1sy4	6	10	acting	act	VBG
cord-259748-x7dq1sy4	6	11	as	as	IN
cord-259748-x7dq1sy4	6	12	essential	essential	JJ
cord-259748-x7dq1sy4	6	13	immune	immune	JJ
cord-259748-x7dq1sy4	6	14	-	-	HYPH
cord-259748-x7dq1sy4	6	15	surveillance	surveillance	NN
cord-259748-x7dq1sy4	6	16	mediators	mediator	NNS
cord-259748-x7dq1sy4	6	17	have	have	VBP
cord-259748-x7dq1sy4	6	18	become	become	VBN
cord-259748-x7dq1sy4	6	19	hot	hot	JJ
cord-259748-x7dq1sy4	6	20	topics	topic	NNS
cord-259748-x7dq1sy4	6	21	of	of	IN
cord-259748-x7dq1sy4	6	22	research	research	NN
cord-259748-x7dq1sy4	6	23	.	.	.
cord-259748-x7dq1sy4	7	1	The	the	DT
cord-259748-x7dq1sy4	7	2	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	7	3	function	function	NN
cord-259748-x7dq1sy4	7	4	of	of	IN
cord-259748-x7dq1sy4	7	5	the	the	DT
cord-259748-x7dq1sy4	7	6	cGAS	cgas	JJ
cord-259748-x7dq1sy4	7	7	-	-	HYPH
cord-259748-x7dq1sy4	7	8	STING	sting	NN
cord-259748-x7dq1sy4	7	9	pathway	pathway	NN
cord-259748-x7dq1sy4	7	10	facilitates	facilitate	VBZ
cord-259748-x7dq1sy4	7	11	type	type	NN
cord-259748-x7dq1sy4	7	12	-	-	:
cord-259748-x7dq1sy4	7	13	I	-PRON-	PRP
cord-259748-x7dq1sy4	7	14	interferon	interferon	NN
cord-259748-x7dq1sy4	7	15	(	(	-LRB-
cord-259748-x7dq1sy4	7	16	IFN	IFN	NNP
cord-259748-x7dq1sy4	7	17	)	)	-RRB-
cord-259748-x7dq1sy4	8	1	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	8	2	signaling	signal	VBG
cord-259748-x7dq1sy4	8	3	responses	response	NNS
cord-259748-x7dq1sy4	8	4	and	and	CC
cord-259748-x7dq1sy4	8	5	other	other	JJ
cord-259748-x7dq1sy4	8	6	cellular	cellular	JJ
cord-259748-x7dq1sy4	8	7	processes	process	NNS
cord-259748-x7dq1sy4	8	8	such	such	JJ
cord-259748-x7dq1sy4	8	9	as	as	IN
cord-259748-x7dq1sy4	8	10	autophagy	autophagy	NN
cord-259748-x7dq1sy4	8	11	,	,	,
cord-259748-x7dq1sy4	8	12	cell	cell	NN
cord-259748-x7dq1sy4	8	13	survival	survival	NN
cord-259748-x7dq1sy4	8	14	,	,	,
cord-259748-x7dq1sy4	8	15	senescence	senescence	NN
cord-259748-x7dq1sy4	8	16	.	.	.
cord-259748-x7dq1sy4	9	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	9	2	-	-	HYPH
cord-259748-x7dq1sy4	9	3	STING	sting	NN
cord-259748-x7dq1sy4	9	4	pathway	pathway	NN
cord-259748-x7dq1sy4	9	5	interplays	interplay	NNS
cord-259748-x7dq1sy4	9	6	with	with	IN
cord-259748-x7dq1sy4	9	7	other	other	JJ
cord-259748-x7dq1sy4	9	8	innate	innate	JJ
cord-259748-x7dq1sy4	9	9	immune	immune	JJ
cord-259748-x7dq1sy4	9	10	pathways	pathway	NNS
cord-259748-x7dq1sy4	9	11	,	,	,
cord-259748-x7dq1sy4	9	12	by	by	IN
cord-259748-x7dq1sy4	9	13	which	which	WDT
cord-259748-x7dq1sy4	9	14	it	-PRON-	PRP
cord-259748-x7dq1sy4	9	15	participates	participate	VBZ
cord-259748-x7dq1sy4	9	16	in	in	IN
cord-259748-x7dq1sy4	9	17	regulating	regulate	VBG
cord-259748-x7dq1sy4	9	18	infection	infection	NN
cord-259748-x7dq1sy4	9	19	,	,	,
cord-259748-x7dq1sy4	9	20	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	9	21	disease	disease	NN
cord-259748-x7dq1sy4	9	22	,	,	,
cord-259748-x7dq1sy4	9	23	and	and	CC
cord-259748-x7dq1sy4	9	24	cancer	cancer	NN
cord-259748-x7dq1sy4	9	25	.	.	.
cord-259748-x7dq1sy4	10	1	The	the	DT
cord-259748-x7dq1sy4	10	2	therapeutic	therapeutic	JJ
cord-259748-x7dq1sy4	10	3	approaches	approach	NNS
cord-259748-x7dq1sy4	10	4	targeting	target	VBG
cord-259748-x7dq1sy4	10	5	this	this	DT
cord-259748-x7dq1sy4	10	6	pathway	pathway	NN
cord-259748-x7dq1sy4	10	7	show	show	NN
cord-259748-x7dq1sy4	10	8	promise	promise	NN
cord-259748-x7dq1sy4	10	9	for	for	IN
cord-259748-x7dq1sy4	10	10	future	future	JJ
cord-259748-x7dq1sy4	10	11	translation	translation	NN
cord-259748-x7dq1sy4	10	12	into	into	IN
cord-259748-x7dq1sy4	10	13	clinical	clinical	JJ
cord-259748-x7dq1sy4	10	14	applications	application	NNS
cord-259748-x7dq1sy4	10	15	.	.	.
cord-259748-x7dq1sy4	11	1	Here	here	RB
cord-259748-x7dq1sy4	11	2	,	,	,
cord-259748-x7dq1sy4	11	3	we	-PRON-	PRP
cord-259748-x7dq1sy4	11	4	present	present	VBP
cord-259748-x7dq1sy4	11	5	a	a	DT
cord-259748-x7dq1sy4	11	6	review	review	NN
cord-259748-x7dq1sy4	11	7	of	of	IN
cord-259748-x7dq1sy4	11	8	the	the	DT
cord-259748-x7dq1sy4	11	9	important	important	JJ
cord-259748-x7dq1sy4	11	10	previous	previous	JJ
cord-259748-x7dq1sy4	11	11	works	work	NNS
cord-259748-x7dq1sy4	11	12	and	and	CC
cord-259748-x7dq1sy4	11	13	recent	recent	JJ
cord-259748-x7dq1sy4	11	14	advances	advance	NNS
cord-259748-x7dq1sy4	11	15	regarding	regard	VBG
cord-259748-x7dq1sy4	11	16	the	the	DT
cord-259748-x7dq1sy4	11	17	cGAS	cgas	JJ
cord-259748-x7dq1sy4	11	18	-	-	HYPH
cord-259748-x7dq1sy4	11	19	STING	sting	NN
cord-259748-x7dq1sy4	11	20	pathway	pathway	NN
cord-259748-x7dq1sy4	11	21	,	,	,
cord-259748-x7dq1sy4	11	22	and	and	CC
cord-259748-x7dq1sy4	11	23	provide	provide	VB
cord-259748-x7dq1sy4	11	24	a	a	DT
cord-259748-x7dq1sy4	11	25	comprehensive	comprehensive	JJ
cord-259748-x7dq1sy4	11	26	understanding	understanding	NN
cord-259748-x7dq1sy4	11	27	of	of	IN
cord-259748-x7dq1sy4	11	28	the	the	DT
cord-259748-x7dq1sy4	11	29	modulatory	modulatory	JJ
cord-259748-x7dq1sy4	11	30	pattern	pattern	NN
cord-259748-x7dq1sy4	11	31	of	of	IN
cord-259748-x7dq1sy4	11	32	the	the	DT
cord-259748-x7dq1sy4	11	33	cGAS	cgas	JJ
cord-259748-x7dq1sy4	11	34	-	-	HYPH
cord-259748-x7dq1sy4	11	35	STING	sting	NN
cord-259748-x7dq1sy4	11	36	pathway	pathway	NN
cord-259748-x7dq1sy4	11	37	under	under	IN
cord-259748-x7dq1sy4	11	38	multifarious	multifarious	JJ
cord-259748-x7dq1sy4	11	39	pathologic	pathologic	JJ
cord-259748-x7dq1sy4	11	40	states	state	NNS
cord-259748-x7dq1sy4	11	41	.	.	.
cord-259748-x7dq1sy4	12	1	Pattern	pattern	NN
cord-259748-x7dq1sy4	12	2	-	-	HYPH
cord-259748-x7dq1sy4	12	3	recognition	recognition	NN
cord-259748-x7dq1sy4	12	4	receptors	receptor	NNS
cord-259748-x7dq1sy4	12	5	(	(	-LRB-
cord-259748-x7dq1sy4	12	6	PRRs	PRRs	NNP
cord-259748-x7dq1sy4	12	7	)	)	-RRB-
cord-259748-x7dq1sy4	12	8	serve	serve	VBP
cord-259748-x7dq1sy4	12	9	as	as	IN
cord-259748-x7dq1sy4	12	10	innate	innate	JJ
cord-259748-x7dq1sy4	12	11	cellular	cellular	JJ
cord-259748-x7dq1sy4	12	12	sensors	sensor	NNS
cord-259748-x7dq1sy4	12	13	of	of	IN
cord-259748-x7dq1sy4	12	14	danger	danger	NN
cord-259748-x7dq1sy4	12	15	signals	signal	NNS
cord-259748-x7dq1sy4	12	16	,	,	,
cord-259748-x7dq1sy4	12	17	such	such	JJ
cord-259748-x7dq1sy4	12	18	as	as	IN
cord-259748-x7dq1sy4	12	19	pathogen	pathogen	NN
cord-259748-x7dq1sy4	12	20	-	-	HYPH
cord-259748-x7dq1sy4	12	21	associated	associate	VBN
cord-259748-x7dq1sy4	12	22	molecular	molecular	JJ
cord-259748-x7dq1sy4	12	23	patterns	pattern	NNS
cord-259748-x7dq1sy4	12	24	(	(	-LRB-
cord-259748-x7dq1sy4	12	25	PAMPs	pamp	NNS
cord-259748-x7dq1sy4	12	26	)	)	-RRB-
cord-259748-x7dq1sy4	12	27	or	or	CC
cord-259748-x7dq1sy4	12	28	danger	danger	NN
cord-259748-x7dq1sy4	12	29	-	-	HYPH
cord-259748-x7dq1sy4	12	30	associated	associate	VBN
cord-259748-x7dq1sy4	12	31	molecular	molecular	JJ
cord-259748-x7dq1sy4	12	32	patterns	pattern	NNS
cord-259748-x7dq1sy4	12	33	(	(	-LRB-
cord-259748-x7dq1sy4	12	34	DAMPs	DAMPs	NNP
cord-259748-x7dq1sy4	12	35	)	)	-RRB-
cord-259748-x7dq1sy4	12	36	,	,	,
cord-259748-x7dq1sy4	12	37	and	and	CC
cord-259748-x7dq1sy4	12	38	yield	yield	VB
cord-259748-x7dq1sy4	12	39	cellular	cellular	JJ
cord-259748-x7dq1sy4	12	40	-	-	HYPH
cord-259748-x7dq1sy4	12	41	stress	stress	NN
cord-259748-x7dq1sy4	12	42	response	response	NN
cord-259748-x7dq1sy4	12	43	.	.	.
cord-259748-x7dq1sy4	13	1	DNA	dna	NN
cord-259748-x7dq1sy4	13	2	molecules	molecule	NNS
cord-259748-x7dq1sy4	13	3	are	be	VBP
cord-259748-x7dq1sy4	13	4	vital	vital	JJ
cord-259748-x7dq1sy4	13	5	genetic	genetic	JJ
cord-259748-x7dq1sy4	13	6	components	component	NNS
cord-259748-x7dq1sy4	13	7	within	within	IN
cord-259748-x7dq1sy4	13	8	cells	cell	NNS
cord-259748-x7dq1sy4	13	9	,	,	,
cord-259748-x7dq1sy4	13	10	which	which	WDT
cord-259748-x7dq1sy4	13	11	are	be	VBP
cord-259748-x7dq1sy4	13	12	compartmentalized	compartmentalize	VBN
cord-259748-x7dq1sy4	13	13	restrictively	restrictively	RB
cord-259748-x7dq1sy4	13	14	into	into	IN
cord-259748-x7dq1sy4	13	15	specific	specific	JJ
cord-259748-x7dq1sy4	13	16	regions	region	NNS
cord-259748-x7dq1sy4	13	17	.	.	.
cord-259748-x7dq1sy4	14	1	The	the	DT
cord-259748-x7dq1sy4	14	2	occasionally	occasionally	RB
cord-259748-x7dq1sy4	14	3	misplaced	misplace	VBN
cord-259748-x7dq1sy4	14	4	DNA	dna	NN
cord-259748-x7dq1sy4	14	5	is	be	VBZ
cord-259748-x7dq1sy4	14	6	degraded	degrade	VBN
cord-259748-x7dq1sy4	14	7	rapidly	rapidly	RB
cord-259748-x7dq1sy4	14	8	by	by	IN
cord-259748-x7dq1sy4	14	9	scavenger	scavenger	NN
cord-259748-x7dq1sy4	14	10	cells	cell	NNS
cord-259748-x7dq1sy4	14	11	and	and	CC
cord-259748-x7dq1sy4	14	12	extracellular	extracellular	JJ
cord-259748-x7dq1sy4	14	13	or	or	CC
cord-259748-x7dq1sy4	14	14	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	14	15	ribonucleases	ribonuclease	NNS
cord-259748-x7dq1sy4	14	16	.	.	.
cord-259748-x7dq1sy4	15	1	Aberrant	aberrant	JJ
cord-259748-x7dq1sy4	15	2	accumulation	accumulation	NN
cord-259748-x7dq1sy4	15	3	of	of	IN
cord-259748-x7dq1sy4	15	4	DNA	DNA	NNP
cord-259748-x7dq1sy4	15	5	is	be	VBZ
cord-259748-x7dq1sy4	15	6	relevant	relevant	JJ
cord-259748-x7dq1sy4	15	7	to	to	IN
cord-259748-x7dq1sy4	15	8	tissue	tissue	NN
cord-259748-x7dq1sy4	15	9	damage	damage	NN
cord-259748-x7dq1sy4	15	10	(	(	-LRB-
cord-259748-x7dq1sy4	15	11	1	1	CD
cord-259748-x7dq1sy4	15	12	)	)	-RRB-
cord-259748-x7dq1sy4	15	13	.	.	.
cord-259748-x7dq1sy4	16	1	In	in	IN
cord-259748-x7dq1sy4	16	2	2008	2008	CD
cord-259748-x7dq1sy4	16	3	,	,	,
cord-259748-x7dq1sy4	16	4	several	several	JJ
cord-259748-x7dq1sy4	16	5	research	research	NN
cord-259748-x7dq1sy4	16	6	teams	team	NNS
cord-259748-x7dq1sy4	16	7	discovered	discover	VBD
cord-259748-x7dq1sy4	16	8	a	a	DT
cord-259748-x7dq1sy4	16	9	new	new	JJ
cord-259748-x7dq1sy4	16	10	protein	protein	NN
cord-259748-x7dq1sy4	16	11	on	on	IN
cord-259748-x7dq1sy4	16	12	the	the	DT
cord-259748-x7dq1sy4	16	13	endoplasmic	endoplasmic	NN
cord-259748-x7dq1sy4	16	14	reticulum	reticulum	NN
cord-259748-x7dq1sy4	16	15	(	(	-LRB-
cord-259748-x7dq1sy4	16	16	ER	ER	NNP
cord-259748-x7dq1sy4	16	17	)	)	-RRB-
cord-259748-x7dq1sy4	16	18	which	which	WDT
cord-259748-x7dq1sy4	16	19	can	can	MD
cord-259748-x7dq1sy4	16	20	be	be	VB
cord-259748-x7dq1sy4	16	21	activated	activate	VBN
cord-259748-x7dq1sy4	16	22	by	by	IN
cord-259748-x7dq1sy4	16	23	immune	immune	JJ
cord-259748-x7dq1sy4	16	24	-	-	HYPH
cord-259748-x7dq1sy4	16	25	stimulatory	stimulatory	JJ
cord-259748-x7dq1sy4	16	26	DNA	dna	NN
cord-259748-x7dq1sy4	16	27	(	(	-LRB-
cord-259748-x7dq1sy4	16	28	ISD	ISD	NNP
cord-259748-x7dq1sy4	16	29	)	)	-RRB-
cord-259748-x7dq1sy4	16	30	and	and	CC
cord-259748-x7dq1sy4	16	31	initiate	initiate	VB
cord-259748-x7dq1sy4	16	32	type	type	NN
cord-259748-x7dq1sy4	16	33	-	-	:
cord-259748-x7dq1sy4	16	34	I	-PRON-	PRP
cord-259748-x7dq1sy4	16	35	interferon	interferon	NN
cord-259748-x7dq1sy4	16	36	(	(	-LRB-
cord-259748-x7dq1sy4	16	37	IFN	IFN	NNP
cord-259748-x7dq1sy4	16	38	)	)	-RRB-
cord-259748-x7dq1sy4	16	39	responses	response	NNS
cord-259748-x7dq1sy4	16	40	,	,	,
cord-259748-x7dq1sy4	16	41	which	which	WDT
cord-259748-x7dq1sy4	16	42	was	be	VBD
cord-259748-x7dq1sy4	16	43	named	name	VBN
cord-259748-x7dq1sy4	16	44	"	"	``
cord-259748-x7dq1sy4	16	45	stimulator	stimulator	NN
cord-259748-x7dq1sy4	16	46	of	of	IN
cord-259748-x7dq1sy4	16	47	interferon	interferon	NN
cord-259748-x7dq1sy4	16	48	genes	gene	NNS
cord-259748-x7dq1sy4	16	49	"	"	''
cord-259748-x7dq1sy4	16	50	(	(	-LRB-
cord-259748-x7dq1sy4	16	51	STING	sting	NN
cord-259748-x7dq1sy4	16	52	,	,	,
cord-259748-x7dq1sy4	16	53	also	also	RB
cord-259748-x7dq1sy4	16	54	known	know	VBN
cord-259748-x7dq1sy4	16	55	as	as	IN
cord-259748-x7dq1sy4	16	56	MITA	MITA	NNP
cord-259748-x7dq1sy4	16	57	,	,	,
cord-259748-x7dq1sy4	16	58	ERIS	ERIS	NNP
cord-259748-x7dq1sy4	16	59	)	)	-RRB-
cord-259748-x7dq1sy4	16	60	(	(	-LRB-
cord-259748-x7dq1sy4	16	61	2	2	LS
cord-259748-x7dq1sy4	16	62	)	)	-RRB-
cord-259748-x7dq1sy4	16	63	(	(	-LRB-
cord-259748-x7dq1sy4	16	64	3	3	LS
cord-259748-x7dq1sy4	16	65	)	)	-RRB-
cord-259748-x7dq1sy4	16	66	(	(	-LRB-
cord-259748-x7dq1sy4	16	67	4	4	LS
cord-259748-x7dq1sy4	16	68	)	)	-RRB-
cord-259748-x7dq1sy4	16	69	.	.	.
cord-259748-x7dq1sy4	17	1	STING	STING	NNP
cord-259748-x7dq1sy4	17	2	does	do	VBZ
cord-259748-x7dq1sy4	17	3	not	not	RB
cord-259748-x7dq1sy4	17	4	bind	bind	VB
cord-259748-x7dq1sy4	17	5	to	to	IN
cord-259748-x7dq1sy4	17	6	DNA	DNA	NNP
cord-259748-x7dq1sy4	17	7	directly	directly	RB
cord-259748-x7dq1sy4	17	8	,	,	,
cord-259748-x7dq1sy4	17	9	and	and	CC
cord-259748-x7dq1sy4	17	10	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	17	11	-	-	HYPH
cord-259748-x7dq1sy4	17	12	derived	derive	VBN
cord-259748-x7dq1sy4	17	13	cyclic	cyclic	NN
cord-259748-x7dq1sy4	17	14	di	di	NN
cord-259748-x7dq1sy4	17	15	-	-	HYPH
cord-259748-x7dq1sy4	17	16	guanylate	guanylate	NN
cord-259748-x7dq1sy4	17	17	monophosphate	monophosphate	NN
cord-259748-x7dq1sy4	17	18	(	(	-LRB-
cord-259748-x7dq1sy4	17	19	c	c	NNP
cord-259748-x7dq1sy4	17	20	-	-	HYPH
cord-259748-x7dq1sy4	17	21	dGMP	dGMP	NNP
cord-259748-x7dq1sy4	17	22	)	)	-RRB-
cord-259748-x7dq1sy4	17	23	or	or	CC
cord-259748-x7dq1sy4	17	24	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	17	25	di	di	NN
cord-259748-x7dq1sy4	17	26	-	-	HYPH
cord-259748-x7dq1sy4	17	27	adenosine	adenosine	NN
cord-259748-x7dq1sy4	17	28	monophosphate	monophosphate	NN
cord-259748-x7dq1sy4	18	1	(	(	-LRB-
cord-259748-x7dq1sy4	18	2	c	c	NN
cord-259748-x7dq1sy4	18	3	-	-	HYPH
cord-259748-x7dq1sy4	18	4	dAMP	dAMP	NNP
cord-259748-x7dq1sy4	18	5	)	)	-RRB-
cord-259748-x7dq1sy4	18	6	were	be	VBD
cord-259748-x7dq1sy4	18	7	confirmed	confirm	VBN
cord-259748-x7dq1sy4	18	8	to	to	TO
cord-259748-x7dq1sy4	18	9	be	be	VB
cord-259748-x7dq1sy4	18	10	ligands	ligand	NNS
cord-259748-x7dq1sy4	18	11	for	for	IN
cord-259748-x7dq1sy4	18	12	STING	sting	NN
cord-259748-x7dq1sy4	18	13	(	(	-LRB-
cord-259748-x7dq1sy4	18	14	5	5	CD
cord-259748-x7dq1sy4	18	15	,	,	,
cord-259748-x7dq1sy4	18	16	6	6	CD
cord-259748-x7dq1sy4	18	17	)	)	-RRB-
cord-259748-x7dq1sy4	18	18	.	.	.
cord-259748-x7dq1sy4	19	1	Subsequently	subsequently	RB
cord-259748-x7dq1sy4	19	2	,	,	,
cord-259748-x7dq1sy4	19	3	it	-PRON-	PRP
cord-259748-x7dq1sy4	19	4	was	be	VBD
cord-259748-x7dq1sy4	19	5	found	find	VBN
cord-259748-x7dq1sy4	19	6	that	that	IN
cord-259748-x7dq1sy4	19	7	some	some	DT
cord-259748-x7dq1sy4	19	8	DNA	dna	NN
cord-259748-x7dq1sy4	19	9	sensors	sensor	NNS
cord-259748-x7dq1sy4	19	10	can	can	MD
cord-259748-x7dq1sy4	19	11	facilitate	facilitate	VB
cord-259748-x7dq1sy4	19	12	STING	sting	NN
cord-259748-x7dq1sy4	19	13	activation	activation	NN
cord-259748-x7dq1sy4	19	14	,	,	,
cord-259748-x7dq1sy4	19	15	such	such	JJ
cord-259748-x7dq1sy4	19	16	as	as	IN
cord-259748-x7dq1sy4	19	17	interferon	interferon	NN
cord-259748-x7dq1sy4	19	18	gamma	gamma	NN
cord-259748-x7dq1sy4	19	19	inducible	inducible	JJ
cord-259748-x7dq1sy4	19	20	protein	protein	NNP
cord-259748-x7dq1sy4	19	21	16	16	CD
cord-259748-x7dq1sy4	19	22	(	(	-LRB-
cord-259748-x7dq1sy4	19	23	IFI16	ifi16	NN
cord-259748-x7dq1sy4	19	24	)	)	-RRB-
cord-259748-x7dq1sy4	19	25	(	(	-LRB-
cord-259748-x7dq1sy4	19	26	7	7	CD
cord-259748-x7dq1sy4	19	27	)	)	-RRB-
cord-259748-x7dq1sy4	19	28	.	.	.
cord-259748-x7dq1sy4	20	1	However	however	RB
cord-259748-x7dq1sy4	20	2	,	,	,
cord-259748-x7dq1sy4	20	3	STING	sting	NN
cord-259748-x7dq1sy4	20	4	activation	activation	NN
cord-259748-x7dq1sy4	20	5	could	could	MD
cord-259748-x7dq1sy4	20	6	not	not	RB
cord-259748-x7dq1sy4	20	7	be	be	VB
cord-259748-x7dq1sy4	20	8	fully	fully	RB
cord-259748-x7dq1sy4	20	9	explained	explain	VBN
cord-259748-x7dq1sy4	20	10	by	by	IN
cord-259748-x7dq1sy4	20	11	the	the	DT
cord-259748-x7dq1sy4	20	12	upstream	upstream	JJ
cord-259748-x7dq1sy4	20	13	factors	factor	NNS
cord-259748-x7dq1sy4	20	14	/	/	SYM
cord-259748-x7dq1sy4	20	15	ligands	ligand	NNS
cord-259748-x7dq1sy4	20	16	that	that	WDT
cord-259748-x7dq1sy4	20	17	had	have	VBD
cord-259748-x7dq1sy4	20	18	been	be	VBN
cord-259748-x7dq1sy4	20	19	found	find	VBN
cord-259748-x7dq1sy4	20	20	.	.	.
cord-259748-x7dq1sy4	21	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	21	2	was	be	VBD
cord-259748-x7dq1sy4	21	3	postulated	postulate	VBN
cord-259748-x7dq1sy4	21	4	that	that	IN
cord-259748-x7dq1sy4	21	5	an	an	DT
cord-259748-x7dq1sy4	21	6	unknown	unknown	JJ
cord-259748-x7dq1sy4	21	7	upstream	upstream	JJ
cord-259748-x7dq1sy4	21	8	regulator	regulator	NN
cord-259748-x7dq1sy4	21	9	might	may	MD
cord-259748-x7dq1sy4	21	10	be	be	VB
cord-259748-x7dq1sy4	21	11	responsible	responsible	JJ
cord-259748-x7dq1sy4	21	12	for	for	IN
cord-259748-x7dq1sy4	21	13	STING	sting	NN
cord-259748-x7dq1sy4	21	14	activation	activation	NN
cord-259748-x7dq1sy4	21	15	.	.	.
cord-259748-x7dq1sy4	22	1	In	in	IN
cord-259748-x7dq1sy4	22	2	2013	2013	CD
cord-259748-x7dq1sy4	22	3	,	,	,
cord-259748-x7dq1sy4	22	4	Wu	Wu	NNP
cord-259748-x7dq1sy4	22	5	and	and	CC
cord-259748-x7dq1sy4	22	6	Sun	Sun	NNP
cord-259748-x7dq1sy4	22	7	found	find	VBD
cord-259748-x7dq1sy4	22	8	that	that	IN
cord-259748-x7dq1sy4	22	9	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	22	10	guanosine	guanosine	NN
cord-259748-x7dq1sy4	22	11	monophosphate	monophosphate	NN
cord-259748-x7dq1sy4	22	12	-	-	HYPH
cord-259748-x7dq1sy4	22	13	adenosine	adenosine	NN
cord-259748-x7dq1sy4	22	14	monophosphate	monophosphate	NN
cord-259748-x7dq1sy4	22	15	(	(	-LRB-
cord-259748-x7dq1sy4	22	16	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	22	17	)	)	-RRB-
cord-259748-x7dq1sy4	22	18	was	be	VBD
cord-259748-x7dq1sy4	22	19	a	a	DT
cord-259748-x7dq1sy4	22	20	novel	novel	JJ
cord-259748-x7dq1sy4	22	21	secondary	secondary	JJ
cord-259748-x7dq1sy4	22	22	messenger	messenger	NN
cord-259748-x7dq1sy4	22	23	serving	serve	VBG
cord-259748-x7dq1sy4	22	24	as	as	IN
cord-259748-x7dq1sy4	22	25	a	a	DT
cord-259748-x7dq1sy4	22	26	ligand	ligand	NN
cord-259748-x7dq1sy4	22	27	of	of	IN
cord-259748-x7dq1sy4	22	28	STING	sting	NN
cord-259748-x7dq1sy4	22	29	(	(	-LRB-
cord-259748-x7dq1sy4	22	30	8)	8)	NN
cord-259748-x7dq1sy4	22	31	.	.	.
cord-259748-x7dq1sy4	23	1	Beside	beside	IN
cord-259748-x7dq1sy4	23	2	it	-PRON-	PRP
cord-259748-x7dq1sy4	23	3	,	,	,
cord-259748-x7dq1sy4	23	4	they	-PRON-	PRP
cord-259748-x7dq1sy4	23	5	purified	purify	VBD
cord-259748-x7dq1sy4	23	6	a	a	DT
cord-259748-x7dq1sy4	23	7	new	new	JJ
cord-259748-x7dq1sy4	23	8	protein	protein	NN
cord-259748-x7dq1sy4	23	9	named	name	VBN
cord-259748-x7dq1sy4	23	10	"	"	``
cord-259748-x7dq1sy4	23	11	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	23	12	-	-	HYPH
cord-259748-x7dq1sy4	23	13	GMP	GMP	NNP
cord-259748-x7dq1sy4	23	14	-	-	HYPH
cord-259748-x7dq1sy4	23	15	AMP	amp	NN
cord-259748-x7dq1sy4	23	16	synthase	synthase	NN
cord-259748-x7dq1sy4	23	17	"	"	''
cord-259748-x7dq1sy4	23	18	(	(	-LRB-
cord-259748-x7dq1sy4	23	19	cGAS	cgas	ADD
cord-259748-x7dq1sy4	23	20	)	)	-RRB-
cord-259748-x7dq1sy4	24	1	that	that	DT
cord-259748-x7dq1sy4	24	2	had	have	VBD
cord-259748-x7dq1sy4	24	3	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	24	4	DNA	dna	NN
cord-259748-x7dq1sy4	24	5	-	-	HYPH
cord-259748-x7dq1sy4	24	6	sensing	sense	VBG
cord-259748-x7dq1sy4	24	7	ability	ability	NN
cord-259748-x7dq1sy4	24	8	and	and	CC
cord-259748-x7dq1sy4	24	9	can	can	MD
cord-259748-x7dq1sy4	24	10	synthesize	synthesize	VB
cord-259748-x7dq1sy4	24	11	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	25	1	(	(	-LRB-
cord-259748-x7dq1sy4	25	2	8)	8)	NNP
cord-259748-x7dq1sy4	25	3	.	.	.
cord-259748-x7dq1sy4	26	1	Also	also	RB
cord-259748-x7dq1sy4	26	2	,	,	,
cord-259748-x7dq1sy4	26	3	they	-PRON-	PRP
cord-259748-x7dq1sy4	26	4	found	find	VBD
cord-259748-x7dq1sy4	26	5	that	that	IN
cord-259748-x7dq1sy4	26	6	the	the	DT
cord-259748-x7dq1sy4	26	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	26	8	-	-	HYPH
cord-259748-x7dq1sy4	26	9	cGAMP	cgamp	JJ
cord-259748-x7dq1sy4	26	10	-	-	HYPH
cord-259748-x7dq1sy4	26	11	STING	sting	NN
cord-259748-x7dq1sy4	26	12	pathway	pathway	NN
cord-259748-x7dq1sy4	26	13	was	be	VBD
cord-259748-x7dq1sy4	26	14	indispensable	indispensable	JJ
cord-259748-x7dq1sy4	26	15	for	for	IN
cord-259748-x7dq1sy4	26	16	host	host	NN
cord-259748-x7dq1sy4	26	17	anti	anti	JJ
cord-259748-x7dq1sy4	26	18	-	-	JJ
cord-259748-x7dq1sy4	26	19	viral	viral	JJ
cord-259748-x7dq1sy4	26	20	immunity	immunity	NN
cord-259748-x7dq1sy4	26	21	(	(	-LRB-
cord-259748-x7dq1sy4	26	22	9	9	CD
cord-259748-x7dq1sy4	26	23	)	)	-RRB-
cord-259748-x7dq1sy4	26	24	.	.	.
cord-259748-x7dq1sy4	27	1	Their	-PRON-	PRP$
cord-259748-x7dq1sy4	27	2	work	work	NN
cord-259748-x7dq1sy4	27	3	filled	fill	VBN
cord-259748-x7dq1sy4	27	4	in	in	IN
cord-259748-x7dq1sy4	27	5	the	the	DT
cord-259748-x7dq1sy4	27	6	gaps	gap	NNS
cord-259748-x7dq1sy4	27	7	missing	miss	VBG
cord-259748-x7dq1sy4	27	8	from	from	IN
cord-259748-x7dq1sy4	27	9	upstream	upstream	RB
cord-259748-x7dq1sy4	27	10	of	of	IN
cord-259748-x7dq1sy4	27	11	STING	sting	NN
cord-259748-x7dq1sy4	27	12	.	.	.
cord-259748-x7dq1sy4	28	1	Stimulator	Stimulator	NNP
cord-259748-x7dq1sy4	28	2	of	of	IN
cord-259748-x7dq1sy4	28	3	interferon	interferon	NN
cord-259748-x7dq1sy4	28	4	genes	gene	NNS
cord-259748-x7dq1sy4	28	5	or	or	CC
cord-259748-x7dq1sy4	28	6	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	28	7	-	-	HYPH
cord-259748-x7dq1sy4	28	8	GMP	GMP	NNP
cord-259748-x7dq1sy4	28	9	-	-	HYPH
cord-259748-x7dq1sy4	28	10	AMP	amp	NN
cord-259748-x7dq1sy4	28	11	synthase	synthase	NN
cord-259748-x7dq1sy4	28	12	is	be	VBZ
cord-259748-x7dq1sy4	28	13	expressed	express	VBN
cord-259748-x7dq1sy4	28	14	widely	widely	RB
cord-259748-x7dq1sy4	28	15	in	in	IN
cord-259748-x7dq1sy4	28	16	a	a	DT
cord-259748-x7dq1sy4	28	17	broad	broad	JJ
cord-259748-x7dq1sy4	28	18	spectrum	spectrum	NN
cord-259748-x7dq1sy4	28	19	of	of	IN
cord-259748-x7dq1sy4	28	20	cells	cell	NNS
cord-259748-x7dq1sy4	28	21	including	include	VBG
cord-259748-x7dq1sy4	28	22	immune	immune	JJ
cord-259748-x7dq1sy4	28	23	,	,	,
cord-259748-x7dq1sy4	28	24	non	non	JJ
cord-259748-x7dq1sy4	28	25	-	-	JJ
cord-259748-x7dq1sy4	28	26	immune	immune	JJ
cord-259748-x7dq1sy4	28	27	,	,	,
cord-259748-x7dq1sy4	28	28	cancer	cancer	NN
cord-259748-x7dq1sy4	28	29	cells	cell	NNS
cord-259748-x7dq1sy4	28	30	(	(	-LRB-
cord-259748-x7dq1sy4	28	31	10	10	CD
cord-259748-x7dq1sy4	28	32	)	)	-RRB-
cord-259748-x7dq1sy4	28	33	.	.	.
cord-259748-x7dq1sy4	29	1	Mounting	mount	VBG
cord-259748-x7dq1sy4	29	2	evidence	evidence	NN
cord-259748-x7dq1sy4	29	3	has	have	VBZ
cord-259748-x7dq1sy4	29	4	demonstrated	demonstrate	VBN
cord-259748-x7dq1sy4	29	5	that	that	IN
cord-259748-x7dq1sy4	29	6	the	the	DT
cord-259748-x7dq1sy4	29	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	29	8	-	-	HYPH
cord-259748-x7dq1sy4	29	9	STING	sting	NN
cord-259748-x7dq1sy4	29	10	pathway	pathway	NN
cord-259748-x7dq1sy4	29	11	is	be	VBZ
cord-259748-x7dq1sy4	29	12	important	important	JJ
cord-259748-x7dq1sy4	29	13	for	for	IN
cord-259748-x7dq1sy4	29	14	mediating	mediate	VBG
cord-259748-x7dq1sy4	29	15	cellular	cellular	JJ
cord-259748-x7dq1sy4	29	16	immune	immune	JJ
cord-259748-x7dq1sy4	29	17	sensing	sensing	NN
cord-259748-x7dq1sy4	29	18	,	,	,
cord-259748-x7dq1sy4	29	19	and	and	CC
cord-259748-x7dq1sy4	29	20	shows	show	VBZ
cord-259748-x7dq1sy4	29	21	particular	particular	JJ
cord-259748-x7dq1sy4	29	22	responses	response	NNS
cord-259748-x7dq1sy4	29	23	pattern	pattern	NN
cord-259748-x7dq1sy4	29	24	to	to	IN
cord-259748-x7dq1sy4	29	25	the	the	DT
cord-259748-x7dq1sy4	29	26	ISD	ISD	NNP
cord-259748-x7dq1sy4	29	27	distinguished	distinguish	VBN
cord-259748-x7dq1sy4	29	28	from	from	IN
cord-259748-x7dq1sy4	29	29	other	other	JJ
cord-259748-x7dq1sy4	29	30	nucleotide	nucleotide	NN
cord-259748-x7dq1sy4	29	31	-	-	HYPH
cord-259748-x7dq1sy4	29	32	sensing	sense	VBG
cord-259748-x7dq1sy4	29	33	pathways	pathway	NNS
cord-259748-x7dq1sy4	29	34	.	.	.
cord-259748-x7dq1sy4	30	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	30	2	is	be	VBZ
cord-259748-x7dq1sy4	30	3	also	also	RB
cord-259748-x7dq1sy4	30	4	regulated	regulate	VBN
cord-259748-x7dq1sy4	30	5	delicately	delicately	RB
cord-259748-x7dq1sy4	30	6	by	by	IN
cord-259748-x7dq1sy4	30	7	several	several	JJ
cord-259748-x7dq1sy4	30	8	molecules	molecule	NNS
cord-259748-x7dq1sy4	30	9	or	or	CC
cord-259748-x7dq1sy4	30	10	feedback	feedback	NN
cord-259748-x7dq1sy4	30	11	loops	loop	NNS
cord-259748-x7dq1sy4	30	12	to	to	TO
cord-259748-x7dq1sy4	30	13	maintain	maintain	VB
cord-259748-x7dq1sy4	30	14	cellular	cellular	JJ
cord-259748-x7dq1sy4	30	15	homeostasis	homeostasis	NN
cord-259748-x7dq1sy4	30	16	.	.	.
cord-259748-x7dq1sy4	31	1	Nevertheless	nevertheless	RB
cord-259748-x7dq1sy4	31	2	,	,	,
cord-259748-x7dq1sy4	31	3	cGAS	cgas	NN
cord-259748-x7dq1sy4	31	4	-	-	HYPH
cord-259748-x7dq1sy4	31	5	cGAMP	cgamp	JJ
cord-259748-x7dq1sy4	31	6	-	-	HYPH
cord-259748-x7dq1sy4	31	7	STING	sting	NN
cord-259748-x7dq1sy4	31	8	pathway	pathway	NN
cord-259748-x7dq1sy4	31	9	itself	-PRON-	PRP
cord-259748-x7dq1sy4	31	10	has	have	VBZ
cord-259748-x7dq1sy4	31	11	distinctive	distinctive	JJ
cord-259748-x7dq1sy4	31	12	or	or	CC
cord-259748-x7dq1sy4	31	13	even	even	RB
cord-259748-x7dq1sy4	31	14	opposing	oppose	VBG
cord-259748-x7dq1sy4	31	15	effects	effect	NNS
cord-259748-x7dq1sy4	31	16	under	under	IN
cord-259748-x7dq1sy4	31	17	different	different	JJ
cord-259748-x7dq1sy4	31	18	conditions	condition	NNS
cord-259748-x7dq1sy4	31	19	.	.	.
cord-259748-x7dq1sy4	32	1	In	in	IN
cord-259748-x7dq1sy4	32	2	this	this	DT
cord-259748-x7dq1sy4	32	3	review	review	NN
cord-259748-x7dq1sy4	32	4	,	,	,
cord-259748-x7dq1sy4	32	5	we	-PRON-	PRP
cord-259748-x7dq1sy4	32	6	cover	cover	VBP
cord-259748-x7dq1sy4	32	7	the	the	DT
cord-259748-x7dq1sy4	32	8	roles	role	NNS
cord-259748-x7dq1sy4	32	9	of	of	IN
cord-259748-x7dq1sy4	32	10	cGAS	cgas	JJ
cord-259748-x7dq1sy4	32	11	-	-	HYPH
cord-259748-x7dq1sy4	32	12	STING	sting	NN
cord-259748-x7dq1sy4	32	13	pathway	pathway	NN
cord-259748-x7dq1sy4	32	14	in	in	IN
cord-259748-x7dq1sy4	32	15	cellular	cellular	JJ
cord-259748-x7dq1sy4	32	16	type	type	NN
cord-259748-x7dq1sy4	32	17	-	-	:
cord-259748-x7dq1sy4	32	18	I	-PRON-	PRP
cord-259748-x7dq1sy4	32	19	IFN	IFN	NNP
cord-259748-x7dq1sy4	32	20	immune	immune	JJ
cord-259748-x7dq1sy4	32	21	response	response	NN
cord-259748-x7dq1sy4	32	22	,	,	,
cord-259748-x7dq1sy4	32	23	and	and	CC
cord-259748-x7dq1sy4	32	24	several	several	JJ
cord-259748-x7dq1sy4	32	25	cellular	cellular	JJ
cord-259748-x7dq1sy4	32	26	processes	process	NNS
cord-259748-x7dq1sy4	32	27	including	include	VBG
cord-259748-x7dq1sy4	32	28	autophagy	autophagy	NN
cord-259748-x7dq1sy4	32	29	,	,	,
cord-259748-x7dq1sy4	32	30	survival	survival	NN
cord-259748-x7dq1sy4	32	31	and	and	CC
cord-259748-x7dq1sy4	32	32	senescence	senescence	NN
cord-259748-x7dq1sy4	32	33	.	.	.
cord-259748-x7dq1sy4	33	1	We	-PRON-	PRP
cord-259748-x7dq1sy4	33	2	also	also	RB
cord-259748-x7dq1sy4	33	3	summarize	summarize	VBP
cord-259748-x7dq1sy4	33	4	the	the	DT
cord-259748-x7dq1sy4	33	5	literature	literature	NN
cord-259748-x7dq1sy4	33	6	on	on	IN
cord-259748-x7dq1sy4	33	7	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	33	8	cellular	cellular	JJ
cord-259748-x7dq1sy4	33	9	mechanisms	mechanism	NNS
cord-259748-x7dq1sy4	33	10	modulating	modulate	VBG
cord-259748-x7dq1sy4	33	11	cGAS	cgas	JJ
cord-259748-x7dq1sy4	33	12	-	-	HYPH
cord-259748-x7dq1sy4	33	13	STING	sting	NN
cord-259748-x7dq1sy4	33	14	pathway	pathway	NN
cord-259748-x7dq1sy4	33	15	as	as	RB
cord-259748-x7dq1sy4	33	16	well	well	RB
cord-259748-x7dq1sy4	33	17	as	as	IN
cord-259748-x7dq1sy4	33	18	its	-PRON-	PRP$
cord-259748-x7dq1sy4	33	19	cross	cross	NN
cord-259748-x7dq1sy4	33	20	-	-	NNS
cord-259748-x7dq1sy4	33	21	regulations	regulation	NNS
cord-259748-x7dq1sy4	33	22	with	with	IN
cord-259748-x7dq1sy4	33	23	other	other	JJ
cord-259748-x7dq1sy4	33	24	DNA	dna	NN
cord-259748-x7dq1sy4	33	25	-	-	HYPH
cord-259748-x7dq1sy4	33	26	sensing	sense	VBG
cord-259748-x7dq1sy4	33	27	pathways	pathway	NNS
cord-259748-x7dq1sy4	33	28	.	.	.
cord-259748-x7dq1sy4	34	1	Moreover	moreover	RB
cord-259748-x7dq1sy4	34	2	,	,	,
cord-259748-x7dq1sy4	34	3	the	the	DT
cord-259748-x7dq1sy4	34	4	inflammationmodulation	inflammationmodulation	NN
cord-259748-x7dq1sy4	34	5	capacities	capacity	NNS
cord-259748-x7dq1sy4	34	6	of	of	IN
cord-259748-x7dq1sy4	34	7	this	this	DT
cord-259748-x7dq1sy4	34	8	pathway	pathway	NN
cord-259748-x7dq1sy4	34	9	in	in	IN
cord-259748-x7dq1sy4	34	10	infectious	infectious	JJ
cord-259748-x7dq1sy4	34	11	disease	disease	NN
cord-259748-x7dq1sy4	34	12	,	,	,
cord-259748-x7dq1sy4	34	13	inflammation	inflammation	NN
cord-259748-x7dq1sy4	34	14	and	and	CC
cord-259748-x7dq1sy4	34	15	cancers	cancer	NNS
cord-259748-x7dq1sy4	34	16	have	have	VBP
cord-259748-x7dq1sy4	34	17	been	be	VBN
cord-259748-x7dq1sy4	34	18	elucidated	elucidate	VBN
cord-259748-x7dq1sy4	34	19	too	too	RB
cord-259748-x7dq1sy4	34	20	,	,	,
cord-259748-x7dq1sy4	34	21	and	and	CC
cord-259748-x7dq1sy4	34	22	a	a	DT
cord-259748-x7dq1sy4	34	23	pervasive	pervasive	JJ
cord-259748-x7dq1sy4	34	24	pattern	pattern	NN
cord-259748-x7dq1sy4	34	25	of	of	IN
cord-259748-x7dq1sy4	34	26	this	this	DT
cord-259748-x7dq1sy4	34	27	pathway	pathway	NN
cord-259748-x7dq1sy4	34	28	has	have	VBZ
cord-259748-x7dq1sy4	34	29	been	be	VBN
cord-259748-x7dq1sy4	34	30	described	describe	VBN
cord-259748-x7dq1sy4	34	31	,	,	,
cord-259748-x7dq1sy4	34	32	which	which	WDT
cord-259748-x7dq1sy4	34	33	could	could	MD
cord-259748-x7dq1sy4	34	34	provide	provide	VB
cord-259748-x7dq1sy4	34	35	a	a	DT
cord-259748-x7dq1sy4	34	36	plausible	plausible	JJ
cord-259748-x7dq1sy4	34	37	explanation	explanation	NN
cord-259748-x7dq1sy4	34	38	of	of	IN
cord-259748-x7dq1sy4	34	39	the	the	DT
cord-259748-x7dq1sy4	34	40	contradictory	contradictory	JJ
cord-259748-x7dq1sy4	34	41	findings	finding	NNS
cord-259748-x7dq1sy4	34	42	of	of	IN
cord-259748-x7dq1sy4	34	43	studies	study	NNS
cord-259748-x7dq1sy4	34	44	.	.	.
cord-259748-x7dq1sy4	35	1	Finally	finally	RB
cord-259748-x7dq1sy4	35	2	,	,	,
cord-259748-x7dq1sy4	35	3	current	current	JJ
cord-259748-x7dq1sy4	35	4	or	or	CC
cord-259748-x7dq1sy4	35	5	prospective	prospective	JJ
cord-259748-x7dq1sy4	35	6	therapeutic	therapeutic	JJ
cord-259748-x7dq1sy4	35	7	strategies	strategy	NNS
cord-259748-x7dq1sy4	35	8	targeting	target	VBG
cord-259748-x7dq1sy4	35	9	the	the	DT
cord-259748-x7dq1sy4	35	10	pathway	pathway	NN
cord-259748-x7dq1sy4	35	11	,	,	,
cord-259748-x7dq1sy4	35	12	and	and	CC
cord-259748-x7dq1sy4	35	13	issues	issue	NNS
cord-259748-x7dq1sy4	35	14	that	that	WDT
cord-259748-x7dq1sy4	35	15	need	need	VBP
cord-259748-x7dq1sy4	35	16	to	to	TO
cord-259748-x7dq1sy4	35	17	be	be	VB
cord-259748-x7dq1sy4	35	18	addressed	address	VBN
cord-259748-x7dq1sy4	35	19	in	in	IN
cord-259748-x7dq1sy4	35	20	the	the	DT
cord-259748-x7dq1sy4	35	21	future	future	NN
cord-259748-x7dq1sy4	35	22	,	,	,
cord-259748-x7dq1sy4	35	23	are	be	VBP
cord-259748-x7dq1sy4	35	24	discussed	discuss	VBN
cord-259748-x7dq1sy4	35	25	.	.	.
cord-259748-x7dq1sy4	36	1	Cyclic	cyclic	JJ
cord-259748-x7dq1sy4	36	2	-	-	HYPH
cord-259748-x7dq1sy4	36	3	GMP	GMP	NNP
cord-259748-x7dq1sy4	36	4	-	-	HYPH
cord-259748-x7dq1sy4	36	5	AMP	amp	NN
cord-259748-x7dq1sy4	36	6	synthase	synthase	NN
cord-259748-x7dq1sy4	36	7	belongs	belong	VBZ
cord-259748-x7dq1sy4	36	8	to	to	IN
cord-259748-x7dq1sy4	36	9	the	the	DT
cord-259748-x7dq1sy4	36	10	structurally	structurally	RB
cord-259748-x7dq1sy4	36	11	conserved	conserved	JJ
cord-259748-x7dq1sy4	36	12	cGAS	cgas	NN
cord-259748-x7dq1sy4	36	13	/	/	SYM
cord-259748-x7dq1sy4	36	14	DncV	DncV	NNP
cord-259748-x7dq1sy4	36	15	-	-	HYPH
cord-259748-x7dq1sy4	36	16	like	like	JJ
cord-259748-x7dq1sy4	36	17	nucleotidyltransferase	nucleotidyltransferase	NNP
cord-259748-x7dq1sy4	36	18	(	(	-LRB-
cord-259748-x7dq1sy4	36	19	CD	CD	NNP
cord-259748-x7dq1sy4	36	20	-	-	HYPH
cord-259748-x7dq1sy4	36	21	Ntases	Ntases	NNP
cord-259748-x7dq1sy4	36	22	)	)	-RRB-
cord-259748-x7dq1sy4	36	23	superfamily	superfamily	NN
cord-259748-x7dq1sy4	36	24	.	.	.
cord-259748-x7dq1sy4	37	1	The	the	DT
cord-259748-x7dq1sy4	37	2	latter	latter	JJ
cord-259748-x7dq1sy4	37	3	is	be	VBZ
cord-259748-x7dq1sy4	37	4	expressed	express	VBN
cord-259748-x7dq1sy4	37	5	universally	universally	RB
cord-259748-x7dq1sy4	37	6	in	in	IN
cord-259748-x7dq1sy4	37	7	prokaryotes	prokaryote	NNS
cord-259748-x7dq1sy4	37	8	and	and	CC
cord-259748-x7dq1sy4	37	9	eukaryotes	eukaryote	NNS
cord-259748-x7dq1sy4	37	10	,	,	,
cord-259748-x7dq1sy4	37	11	and	and	CC
cord-259748-x7dq1sy4	37	12	can	can	MD
cord-259748-x7dq1sy4	37	13	use	use	VB
cord-259748-x7dq1sy4	37	14	purines	purine	NNS
cord-259748-x7dq1sy4	37	15	or	or	CC
cord-259748-x7dq1sy4	37	16	pyrimidines	pyrimidine	NNS
cord-259748-x7dq1sy4	37	17	selectively	selectively	RB
cord-259748-x7dq1sy4	37	18	as	as	IN
cord-259748-x7dq1sy4	37	19	substrates	substrate	NNS
cord-259748-x7dq1sy4	37	20	for	for	IN
cord-259748-x7dq1sy4	37	21	the	the	DT
cord-259748-x7dq1sy4	37	22	production	production	NN
cord-259748-x7dq1sy4	37	23	of	of	IN
cord-259748-x7dq1sy4	37	24	linear	linear	JJ
cord-259748-x7dq1sy4	37	25	or	or	CC
cord-259748-x7dq1sy4	37	26	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	37	27	di	di	NN
cord-259748-x7dq1sy4	37	28	-	-	:
cord-259748-x7dq1sy4	37	29	or	or	CC
cord-259748-x7dq1sy4	37	30	even	even	RB
cord-259748-x7dq1sy4	37	31	tri	tri	JJ
cord-259748-x7dq1sy4	37	32	-	-	JJ
cord-259748-x7dq1sy4	37	33	nucleotide	nucleotide	JJ
cord-259748-x7dq1sy4	37	34	compounds	compound	NNS
cord-259748-x7dq1sy4	37	35	,	,	,
cord-259748-x7dq1sy4	37	36	which	which	WDT
cord-259748-x7dq1sy4	37	37	act	act	VBP
cord-259748-x7dq1sy4	37	38	as	as	IN
cord-259748-x7dq1sy4	37	39	secondary	secondary	JJ
cord-259748-x7dq1sy4	37	40	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	37	41	messengers	messenger	NNS
cord-259748-x7dq1sy4	37	42	(	(	-LRB-
cord-259748-x7dq1sy4	37	43	11	11	CD
cord-259748-x7dq1sy4	37	44	)	)	-RRB-
cord-259748-x7dq1sy4	37	45	.	.	.
cord-259748-x7dq1sy4	38	1	Cyclic	cyclic	JJ
cord-259748-x7dq1sy4	38	2	-	-	HYPH
cord-259748-x7dq1sy4	38	3	GMP	GMP	NNP
cord-259748-x7dq1sy4	38	4	-	-	HYPH
cord-259748-x7dq1sy4	38	5	AMP	AMP	NNP
cord-259748-x7dq1sy4	38	6	synthase	synthase	NN
cord-259748-x7dq1sy4	38	7	is	be	VBZ
cord-259748-x7dq1sy4	38	8	distributed	distribute	VBN
cord-259748-x7dq1sy4	38	9	mainly	mainly	RB
cord-259748-x7dq1sy4	38	10	in	in	IN
cord-259748-x7dq1sy4	38	11	the	the	DT
cord-259748-x7dq1sy4	38	12	cytosol	cytosol	NN
cord-259748-x7dq1sy4	38	13	(	(	-LRB-
cord-259748-x7dq1sy4	38	14	also	also	RB
cord-259748-x7dq1sy4	38	15	nucleus	nucleus	JJ
cord-259748-x7dq1sy4	38	16	in	in	IN
cord-259748-x7dq1sy4	38	17	some	some	DT
cord-259748-x7dq1sy4	38	18	specific	specific	JJ
cord-259748-x7dq1sy4	38	19	conditions	condition	NNS
cord-259748-x7dq1sy4	38	20	)	)	-RRB-
cord-259748-x7dq1sy4	38	21	(	(	-LRB-
cord-259748-x7dq1sy4	38	22	8)	8)	NNP
cord-259748-x7dq1sy4	38	23	.	.	.
cord-259748-x7dq1sy4	39	1	Generally	generally	RB
cord-259748-x7dq1sy4	39	2	speaking	speak	VBG
cord-259748-x7dq1sy4	39	3	,	,	,
cord-259748-x7dq1sy4	39	4	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	39	5	is	be	VBZ
cord-259748-x7dq1sy4	39	6	activated	activate	VBN
cord-259748-x7dq1sy4	39	7	upon	upon	IN
cord-259748-x7dq1sy4	39	8	the	the	DT
cord-259748-x7dq1sy4	39	9	recognition	recognition	NN
cord-259748-x7dq1sy4	39	10	of	of	IN
cord-259748-x7dq1sy4	39	11	B	b	NN
cord-259748-x7dq1sy4	39	12	-	-	HYPH
cord-259748-x7dq1sy4	39	13	type	type	NN
cord-259748-x7dq1sy4	39	14	double	double	RB
cord-259748-x7dq1sy4	39	15	-	-	HYPH
cord-259748-x7dq1sy4	39	16	stranded	strand	VBN
cord-259748-x7dq1sy4	39	17	DNA	dna	NN
cord-259748-x7dq1sy4	39	18	(	(	-LRB-
cord-259748-x7dq1sy4	39	19	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	39	20	)	)	-RRB-
cord-259748-x7dq1sy4	39	21	without	without	IN
cord-259748-x7dq1sy4	39	22	sequence	sequence	NN
cord-259748-x7dq1sy4	39	23	-	-	HYPH
cord-259748-x7dq1sy4	39	24	specificity	specificity	NN
cord-259748-x7dq1sy4	39	25	but	but	CC
cord-259748-x7dq1sy4	39	26	not	not	RB
cord-259748-x7dq1sy4	39	27	A	a	DT
cord-259748-x7dq1sy4	39	28	-	-	HYPH
cord-259748-x7dq1sy4	39	29	type	type	NN
cord-259748-x7dq1sy4	39	30	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	39	31	or	or	CC
cord-259748-x7dq1sy4	39	32	RNA	RNA	NNP
cord-259748-x7dq1sy4	39	33	(	(	-LRB-
cord-259748-x7dq1sy4	39	34	12	12	CD
cord-259748-x7dq1sy4	39	35	,	,	,
cord-259748-x7dq1sy4	39	36	13	13	CD
cord-259748-x7dq1sy4	39	37	)	)	-RRB-
cord-259748-x7dq1sy4	39	38	.	.	.
cord-259748-x7dq1sy4	40	1	Hybrid	hybrid	JJ
cord-259748-x7dq1sy4	40	2	DNA	dna	NN
cord-259748-x7dq1sy4	40	3	:	:	:
cord-259748-x7dq1sy4	40	4	RNA	RNA	NNP
cord-259748-x7dq1sy4	40	5	or	or	CC
cord-259748-x7dq1sy4	40	6	stemlike	stemlike	VB
cord-259748-x7dq1sy4	40	7	single	single	RB
cord-259748-x7dq1sy4	40	8	-	-	HYPH
cord-259748-x7dq1sy4	40	9	stranded	strand	VBN
cord-259748-x7dq1sy4	40	10	DNA	dna	NN
cord-259748-x7dq1sy4	40	11	(	(	-LRB-
cord-259748-x7dq1sy4	40	12	ssDNA	ssdna	NN
cord-259748-x7dq1sy4	40	13	)	)	-RRB-
cord-259748-x7dq1sy4	40	14	are	be	VBP
cord-259748-x7dq1sy4	40	15	also	also	RB
cord-259748-x7dq1sy4	40	16	low	low	JJ
cord-259748-x7dq1sy4	40	17	-	-	HYPH
cord-259748-x7dq1sy4	40	18	affinity	affinity	NN
cord-259748-x7dq1sy4	40	19	ligands	ligand	NNS
cord-259748-x7dq1sy4	40	20	for	for	IN
cord-259748-x7dq1sy4	40	21	cGAS	cgas	NN
cord-259748-x7dq1sy4	40	22	(	(	-LRB-
cord-259748-x7dq1sy4	40	23	14	14	CD
cord-259748-x7dq1sy4	40	24	,	,	,
cord-259748-x7dq1sy4	40	25	15	15	CD
cord-259748-x7dq1sy4	40	26	)	)	-RRB-
cord-259748-x7dq1sy4	40	27	.	.	.
cord-259748-x7dq1sy4	41	1	After	after	IN
cord-259748-x7dq1sy4	41	2	binding	bind	VBG
cord-259748-x7dq1sy4	41	3	with	with	IN
cord-259748-x7dq1sy4	41	4	ligands	ligand	NNS
cord-259748-x7dq1sy4	41	5	,	,	,
cord-259748-x7dq1sy4	41	6	cGAS	cgas	NN
cord-259748-x7dq1sy4	41	7	undergoes	undergo	VBZ
cord-259748-x7dq1sy4	41	8	an	an	DT
cord-259748-x7dq1sy4	41	9	allosteric	allosteric	JJ
cord-259748-x7dq1sy4	41	10	structural	structural	JJ
cord-259748-x7dq1sy4	41	11	change	change	NN
cord-259748-x7dq1sy4	41	12	,	,	,
cord-259748-x7dq1sy4	41	13	and	and	CC
cord-259748-x7dq1sy4	41	14	subsequently	subsequently	RB
cord-259748-x7dq1sy4	41	15	catalyzes	catalyze	VBZ
cord-259748-x7dq1sy4	41	16	its	-PRON-	PRP$
cord-259748-x7dq1sy4	41	17	substrates	substrate	NNS
cord-259748-x7dq1sy4	41	18	guanosine	guanosine	NN
cord-259748-x7dq1sy4	41	19	triphosphate	triphosphate	NN
cord-259748-x7dq1sy4	41	20	(	(	-LRB-
cord-259748-x7dq1sy4	41	21	GTP	GTP	NNP
cord-259748-x7dq1sy4	41	22	)	)	-RRB-
cord-259748-x7dq1sy4	41	23	and	and	CC
cord-259748-x7dq1sy4	41	24	adenosine	adenosine	NN
cord-259748-x7dq1sy4	41	25	triphosphate	triphosphate	NN
cord-259748-x7dq1sy4	41	26	(	(	-LRB-
cord-259748-x7dq1sy4	41	27	ATP	ATP	NNP
cord-259748-x7dq1sy4	41	28	)	)	-RRB-
cord-259748-x7dq1sy4	41	29	to	to	TO
cord-259748-x7dq1sy4	41	30	produce	produce	VB
cord-259748-x7dq1sy4	41	31	a	a	DT
cord-259748-x7dq1sy4	41	32	mixed	mixed	JJ
cord-259748-x7dq1sy4	41	33	phosphodiester	phosphodiester	NN
cord-259748-x7dq1sy4	41	34	-	-	HYPH
cord-259748-x7dq1sy4	41	35	linked	link	VBN
cord-259748-x7dq1sy4	41	36	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	41	37	dinucleotide	dinucleotide	NN
cord-259748-x7dq1sy4	41	38	:	:	:
cord-259748-x7dq1sy4	42	1	G(2	G(2	NNP
cord-259748-x7dq1sy4	42	2	-5	-5	NNP
cord-259748-x7dq1sy4	42	3	)	)	-RRB-
cord-259748-x7dq1sy4	43	1	pA	pA	NNP
cord-259748-x7dq1sy4	43	2	(	(	-LRB-
cord-259748-x7dq1sy4	43	3	3	3	CD
cord-259748-x7dq1sy4	43	4	-5	-5	CD
cord-259748-x7dq1sy4	43	5	)	)	-RRB-
cord-259748-x7dq1sy4	44	1	p	p	NNP
cord-259748-x7dq1sy4	44	2	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	45	1	(	(	-LRB-
cord-259748-x7dq1sy4	45	2	abbreviated	abbreviate	VBN
cord-259748-x7dq1sy4	45	3	as	as	IN
cord-259748-x7dq1sy4	45	4	2	2	CD
cord-259748-x7dq1sy4	45	5	,	,	,
cord-259748-x7dq1sy4	45	6	3	3	CD
cord-259748-x7dq1sy4	45	7	-cGAMP	-cGAMP	NNPS
cord-259748-x7dq1sy4	45	8	or	or	CC
cord-259748-x7dq1sy4	45	9	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	45	10	)	)	-RRB-
cord-259748-x7dq1sy4	46	1	(	(	-LRB-
cord-259748-x7dq1sy4	46	2	16	16	CD
cord-259748-x7dq1sy4	46	3	)	)	-RRB-
cord-259748-x7dq1sy4	46	4	.	.	.
cord-259748-x7dq1sy4	47	1	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	47	2	also	also	RB
cord-259748-x7dq1sy4	47	3	catalyze	catalyze	VBP
cord-259748-x7dq1sy4	47	4	the	the	DT
cord-259748-x7dq1sy4	47	5	synthesis	synthesis	NN
cord-259748-x7dq1sy4	47	6	of	of	IN
cord-259748-x7dq1sy4	47	7	linear	linear	NNP
cord-259748-x7dq1sy4	47	8	dinucleotides	dinucleotide	NNS
cord-259748-x7dq1sy4	47	9	such	such	JJ
cord-259748-x7dq1sy4	47	10	as	as	IN
cord-259748-x7dq1sy4	48	1	AMP-2	amp-2	IN
cord-259748-x7dq1sy4	48	2	-ATP	-ATP	:
cord-259748-x7dq1sy4	48	3	,	,	.
cord-259748-x7dq1sy4	49	1	GMP-2	GMP-2	NNP
cord-259748-x7dq1sy4	49	2	-GTP	-gtp	ADD
cord-259748-x7dq1sy4	50	1	,	,	,
cord-259748-x7dq1sy4	51	1	and	and	CC
cord-259748-x7dq1sy4	51	2	AMP-2	AMP-2	NNP
cord-259748-x7dq1sy4	51	3	-GTP	-GTP	:
cord-259748-x7dq1sy4	51	4	as	as	IN
cord-259748-x7dq1sy4	51	5	intermediate	intermediate	JJ
cord-259748-x7dq1sy4	51	6	products	product	NNS
cord-259748-x7dq1sy4	51	7	(	(	-LRB-
cord-259748-x7dq1sy4	51	8	17	17	CD
cord-259748-x7dq1sy4	51	9	)	)	-RRB-
cord-259748-x7dq1sy4	52	1	.	.	.
cord-259748-x7dq1sy4	53	1	There	there	EX
cord-259748-x7dq1sy4	53	2	are	be	VBP
cord-259748-x7dq1sy4	53	3	two	two	CD
cord-259748-x7dq1sy4	53	4	major	major	JJ
cord-259748-x7dq1sy4	53	5	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	53	6	-	-	HYPH
cord-259748-x7dq1sy4	53	7	binding	bind	VBG
cord-259748-x7dq1sy4	53	8	sites	site	NNS
cord-259748-x7dq1sy4	53	9	on	on	IN
cord-259748-x7dq1sy4	53	10	opposite	opposite	JJ
cord-259748-x7dq1sy4	53	11	sides	side	NNS
cord-259748-x7dq1sy4	53	12	of	of	IN
cord-259748-x7dq1sy4	53	13	the	the	DT
cord-259748-x7dq1sy4	53	14	catalytic	catalytic	JJ
cord-259748-x7dq1sy4	53	15	pocket	pocket	NN
cord-259748-x7dq1sy4	53	16	:	:	:
cord-259748-x7dq1sy4	53	17	A	a	NN
cord-259748-x7dq1sy4	53	18	and	and	CC
cord-259748-x7dq1sy4	53	19	B	B	NNP
cord-259748-x7dq1sy4	53	20	site	site	NN
cord-259748-x7dq1sy4	53	21	.	.	.
cord-259748-x7dq1sy4	54	1	Site	site	NN
cord-259748-x7dq1sy4	54	2	A	a	NN
cord-259748-x7dq1sy4	54	3	is	be	VBZ
cord-259748-x7dq1sy4	54	4	the	the	DT
cord-259748-x7dq1sy4	54	5	primary	primary	JJ
cord-259748-x7dq1sy4	54	6	contact	contact	NN
cord-259748-x7dq1sy4	54	7	surface	surface	NN
cord-259748-x7dq1sy4	54	8	for	for	IN
cord-259748-x7dq1sy4	54	9	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	54	10	,	,	,
cord-259748-x7dq1sy4	54	11	whereas	whereas	IN
cord-259748-x7dq1sy4	54	12	site	site	NN
cord-259748-x7dq1sy4	54	13	B	b	NN
cord-259748-x7dq1sy4	54	14	is	be	VBZ
cord-259748-x7dq1sy4	54	15	complementary	complementary	JJ
cord-259748-x7dq1sy4	54	16	,	,	,
cord-259748-x7dq1sy4	54	17	binding	bind	VBG
cord-259748-x7dq1sy4	54	18	another	another	DT
cord-259748-x7dq1sy4	54	19	dsDNA	dsdna	NN
cord-259748-x7dq1sy4	54	20	.	.	.
cord-259748-x7dq1sy4	55	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	55	2	allows	allow	VBZ
cord-259748-x7dq1sy4	55	3	for	for	IN
cord-259748-x7dq1sy4	55	4	cGAS	cgas	NN
cord-259748-x7dq1sy4	55	5	to	to	IN
cord-259748-x7dq1sy4	55	6	the	the	DT
cord-259748-x7dq1sy4	55	7	formation	formation	NN
cord-259748-x7dq1sy4	55	8	of	of	IN
cord-259748-x7dq1sy4	55	9	a	a	DT
cord-259748-x7dq1sy4	55	10	2:2	2:2	CD
cord-259748-x7dq1sy4	55	11	cGAS	cgas	NN
cord-259748-x7dq1sy4	55	12	:	:	:
cord-259748-x7dq1sy4	55	13	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	55	14	complex	complex	JJ
cord-259748-x7dq1sy4	55	15	structure	structure	NN
cord-259748-x7dq1sy4	55	16	directed	direct	VBN
cord-259748-x7dq1sy4	55	17	into	into	IN
cord-259748-x7dq1sy4	55	18	two	two	CD
cord-259748-x7dq1sy4	55	19	orientations	orientation	NNS
cord-259748-x7dq1sy4	55	20	with	with	IN
cord-259748-x7dq1sy4	55	21	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	55	22	at	at	RB
cord-259748-x7dq1sy4	55	23	least	least	RBS
cord-259748-x7dq1sy4	55	24	20	20	CD
cord-259748-x7dq1sy4	55	25	bp	bp	NNP
cord-259748-x7dq1sy4	55	26	(	(	-LRB-
cord-259748-x7dq1sy4	55	27	18	18	CD
cord-259748-x7dq1sy4	55	28	)	)	-RRB-
cord-259748-x7dq1sy4	55	29	(	(	-LRB-
cord-259748-x7dq1sy4	55	30	19	19	CD
cord-259748-x7dq1sy4	55	31	)	)	-RRB-
cord-259748-x7dq1sy4	55	32	(	(	-LRB-
cord-259748-x7dq1sy4	55	33	20	20	CD
cord-259748-x7dq1sy4	55	34	)	)	-RRB-
cord-259748-x7dq1sy4	56	1	(	(	-LRB-
cord-259748-x7dq1sy4	56	2	Figure	figure	NN
cord-259748-x7dq1sy4	56	3	1A	1a	NN
cord-259748-x7dq1sy4	56	4	)	)	-RRB-
cord-259748-x7dq1sy4	56	5	.	.	.
cord-259748-x7dq1sy4	57	1	Increased	increase	VBN
cord-259748-x7dq1sy4	57	2	numbers	number	NNS
cord-259748-x7dq1sy4	57	3	of	of	IN
cord-259748-x7dq1sy4	57	4	back	back	NN
cord-259748-x7dq1sy4	57	5	-	-	HYPH
cord-259748-x7dq1sy4	57	6	to	to	IN
cord-259748-x7dq1sy4	57	7	-	-	HYPH
cord-259748-x7dq1sy4	57	8	back	back	NN
cord-259748-x7dq1sy4	57	9	dimers	dimer	NNS
cord-259748-x7dq1sy4	57	10	of	of	IN
cord-259748-x7dq1sy4	57	11	cGAS	cgas	NN
cord-259748-x7dq1sy4	57	12	hold	hold	VBP
cord-259748-x7dq1sy4	57	13	the	the	DT
cord-259748-x7dq1sy4	57	14	two	two	CD
cord-259748-x7dq1sy4	57	15	dsDNA	dsdna	NN
cord-259748-x7dq1sy4	57	16	molecules	molecule	NNS
cord-259748-x7dq1sy4	57	17	together	together	RB
cord-259748-x7dq1sy4	57	18	and	and	CC
cord-259748-x7dq1sy4	57	19	permit	permit	VB
cord-259748-x7dq1sy4	57	20	successive	successive	JJ
cord-259748-x7dq1sy4	57	21	recruitment	recruitment	NN
cord-259748-x7dq1sy4	57	22	of	of	IN
cord-259748-x7dq1sy4	57	23	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	57	24	which	which	WDT
cord-259748-x7dq1sy4	57	25	,	,	,
cord-259748-x7dq1sy4	57	26	consequently	consequently	RB
cord-259748-x7dq1sy4	57	27	,	,	,
cord-259748-x7dq1sy4	57	28	forms	form	VBZ
cord-259748-x7dq1sy4	57	29	a	a	DT
cord-259748-x7dq1sy4	57	30	2n:2	2n:2	CD
cord-259748-x7dq1sy4	57	31	cGAS	cgas	NN
cord-259748-x7dq1sy4	57	32	:	:	:
cord-259748-x7dq1sy4	57	33	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	57	34	higherordered	higherordere	VBN
cord-259748-x7dq1sy4	57	35	"	"	``
cord-259748-x7dq1sy4	57	36	ladder	ladder	NN
cord-259748-x7dq1sy4	57	37	-	-	HYPH
cord-259748-x7dq1sy4	57	38	like	like	JJ
cord-259748-x7dq1sy4	57	39	"	"	``
cord-259748-x7dq1sy4	57	40	oligomerization	oligomerization	NN
cord-259748-x7dq1sy4	57	41	,	,	,
cord-259748-x7dq1sy4	57	42	with	with	IN
cord-259748-x7dq1sy4	57	43	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	57	44	arrayed	array	VBN
cord-259748-x7dq1sy4	57	45	"	"	``
cord-259748-x7dq1sy4	57	46	head	head	NN
cord-259748-x7dq1sy4	57	47	to	to	IN
cord-259748-x7dq1sy4	57	48	head	head	NN
cord-259748-x7dq1sy4	57	49	/	/	SYM
cord-259748-x7dq1sy4	57	50	tail	tail	NN
cord-259748-x7dq1sy4	57	51	to	to	IN
cord-259748-x7dq1sy4	57	52	tail	tail	NN
cord-259748-x7dq1sy4	57	53	"	"	''
cord-259748-x7dq1sy4	57	54	(	(	-LRB-
cord-259748-x7dq1sy4	57	55	19	19	CD
cord-259748-x7dq1sy4	57	56	,	,	,
cord-259748-x7dq1sy4	57	57	21	21	CD
cord-259748-x7dq1sy4	57	58	)	)	-RRB-
cord-259748-x7dq1sy4	57	59	.	.	.
cord-259748-x7dq1sy4	58	1	The	the	DT
cord-259748-x7dq1sy4	58	2	DNA	dna	NN
cord-259748-x7dq1sy4	58	3	-	-	HYPH
cord-259748-x7dq1sy4	58	4	binding	bind	VBG
cord-259748-x7dq1sy4	58	5	protein	protein	NN
cord-259748-x7dq1sy4	58	6	HU	HU	NNP
cord-259748-x7dq1sy4	58	7	,	,	,
cord-259748-x7dq1sy4	58	8	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	58	9	transcription	transcription	NN
cord-259748-x7dq1sy4	58	10	factor	factor	NN
cord-259748-x7dq1sy4	59	1	A	a	DT
cord-259748-x7dq1sy4	59	2	(	(	-LRB-
cord-259748-x7dq1sy4	59	3	TFAM	TFAM	NNP
cord-259748-x7dq1sy4	59	4	)	)	-RRB-
cord-259748-x7dq1sy4	59	5	,	,	,
cord-259748-x7dq1sy4	59	6	or	or	CC
cord-259748-x7dq1sy4	59	7	bacterial	bacterial	JJ
cord-259748-x7dq1sy4	59	8	high	high	JJ
cord-259748-x7dq1sy4	59	9	mobility	mobility	NN
cord-259748-x7dq1sy4	59	10	group	group	NN
cord-259748-x7dq1sy4	59	11	box	box	NN
cord-259748-x7dq1sy4	59	12	1	1	CD
cord-259748-x7dq1sy4	59	13	protein	protein	NN
cord-259748-x7dq1sy4	59	14	(	(	-LRB-
cord-259748-x7dq1sy4	59	15	HMGB1	HMGB1	NNP
cord-259748-x7dq1sy4	59	16	)	)	-RRB-
cord-259748-x7dq1sy4	59	17	can	can	MD
cord-259748-x7dq1sy4	59	18	bend	bend	VB
cord-259748-x7dq1sy4	59	19	the	the	DT
cord-259748-x7dq1sy4	59	20	dsDNA	dsdna	NN
cord-259748-x7dq1sy4	59	21	into	into	IN
cord-259748-x7dq1sy4	59	22	a	a	DT
cord-259748-x7dq1sy4	59	23	U	u	NN
cord-259748-x7dq1sy4	59	24	-	-	HYPH
cord-259748-x7dq1sy4	59	25	shaped	shape	VBN
cord-259748-x7dq1sy4	59	26	structure	structure	NN
cord-259748-x7dq1sy4	59	27	and	and	CC
cord-259748-x7dq1sy4	59	28	,	,	,
cord-259748-x7dq1sy4	59	29	thus	thus	RB
cord-259748-x7dq1sy4	59	30	,	,	,
cord-259748-x7dq1sy4	59	31	facilitate	facilitate	VBP
cord-259748-x7dq1sy4	59	32	binding	binding	NN
cord-259748-x7dq1sy4	59	33	of	of	IN
cord-259748-x7dq1sy4	59	34	cGAS	cgas	JJ
cord-259748-x7dq1sy4	59	35	dimers	dimer	NNS
cord-259748-x7dq1sy4	59	36	to	to	IN
cord-259748-x7dq1sy4	59	37	the	the	DT
cord-259748-x7dq1sy4	59	38	same	same	JJ
cord-259748-x7dq1sy4	59	39	strand	strand	NN
cord-259748-x7dq1sy4	59	40	as	as	IN
cord-259748-x7dq1sy4	59	41	it	-PRON-	PRP
cord-259748-x7dq1sy4	59	42	travels	travel	VBZ
cord-259748-x7dq1sy4	59	43	in	in	IN
cord-259748-x7dq1sy4	59	44	opposite	opposite	JJ
cord-259748-x7dq1sy4	59	45	directions	direction	NNS
cord-259748-x7dq1sy4	59	46	(	(	-LRB-
cord-259748-x7dq1sy4	59	47	21	21	CD
cord-259748-x7dq1sy4	59	48	)	)	-RRB-
cord-259748-x7dq1sy4	59	49	(	(	-LRB-
cord-259748-x7dq1sy4	59	50	Figure	figure	NN
cord-259748-x7dq1sy4	59	51	1B	1b	CD
cord-259748-x7dq1sy4	59	52	)	)	-RRB-
cord-259748-x7dq1sy4	59	53	.	.	.
cord-259748-x7dq1sy4	60	1	Human	human	JJ
cord-259748-x7dq1sy4	60	2	cGAS	cgas	NN
cord-259748-x7dq1sy4	60	3	,	,	,
cord-259748-x7dq1sy4	60	4	unlike	unlike	IN
cord-259748-x7dq1sy4	60	5	mouse	mouse	NN
cord-259748-x7dq1sy4	60	6	cGAS	cgas	NN
cord-259748-x7dq1sy4	60	7	,	,	,
cord-259748-x7dq1sy4	60	8	is	be	VBZ
cord-259748-x7dq1sy4	60	9	prone	prone	JJ
cord-259748-x7dq1sy4	60	10	to	to	IN
cord-259748-x7dq1sy4	60	11	formation	formation	NN
cord-259748-x7dq1sy4	60	12	of	of	IN
cord-259748-x7dq1sy4	60	13	this	this	DT
cord-259748-x7dq1sy4	60	14	ladder	ladder	NN
cord-259748-x7dq1sy4	60	15	-	-	HYPH
cord-259748-x7dq1sy4	60	16	like	like	JJ
cord-259748-x7dq1sy4	60	17	network	network	NN
cord-259748-x7dq1sy4	60	18	with	with	IN
cord-259748-x7dq1sy4	60	19	long	long	JJ
cord-259748-x7dq1sy4	60	20	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	60	21	,	,	,
cord-259748-x7dq1sy4	60	22	because	because	IN
cord-259748-x7dq1sy4	60	23	of	of	IN
cord-259748-x7dq1sy4	60	24	the	the	DT
cord-259748-x7dq1sy4	60	25	human	human	JJ
cord-259748-x7dq1sy4	60	26	-	-	HYPH
cord-259748-x7dq1sy4	60	27	specific	specific	JJ
cord-259748-x7dq1sy4	60	28	residues	residue	NNS
cord-259748-x7dq1sy4	60	29	K187	K187	NNS
cord-259748-x7dq1sy4	60	30	and	and	CC
cord-259748-x7dq1sy4	60	31	L195	L195	NNS
cord-259748-x7dq1sy4	60	32	.	.	.
cord-259748-x7dq1sy4	61	1	These	these	DT
cord-259748-x7dq1sy4	61	2	two	two	CD
cord-259748-x7dq1sy4	61	3	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	61	4	-	-	HYPH
cord-259748-x7dq1sy4	61	5	interfacing	interface	VBG
cord-259748-x7dq1sy4	61	6	residues	residue	NNS
cord-259748-x7dq1sy4	61	7	of	of	IN
cord-259748-x7dq1sy4	62	1	site	site	NN
cord-259748-x7dq1sy4	62	2	A	a	DT
cord-259748-x7dq1sy4	62	3	loosen	loosen	NN
cord-259748-x7dq1sy4	62	4	the	the	DT
cord-259748-x7dq1sy4	62	5	interaction	interaction	NN
cord-259748-x7dq1sy4	62	6	of	of	IN
cord-259748-x7dq1sy4	62	7	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	62	8	with	with	IN
cord-259748-x7dq1sy4	62	9	cGAS	cgas	NN
cord-259748-x7dq1sy4	62	10	,	,	,
cord-259748-x7dq1sy4	62	11	leading	lead	VBG
cord-259748-x7dq1sy4	62	12	to	to	IN
cord-259748-x7dq1sy4	62	13	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	62	14	curving	curve	VBG
cord-259748-x7dq1sy4	62	15	and	and	CC
cord-259748-x7dq1sy4	62	16	allowing	allow	VBG
cord-259748-x7dq1sy4	62	17	more	more	RBR
cord-259748-x7dq1sy4	62	18	convenient	convenient	JJ
cord-259748-x7dq1sy4	62	19	binding	binding	NN
cord-259748-x7dq1sy4	62	20	for	for	IN
cord-259748-x7dq1sy4	62	21	the	the	DT
cord-259748-x7dq1sy4	62	22	next	next	JJ
cord-259748-x7dq1sy4	62	23	adjacent	adjacent	JJ
cord-259748-x7dq1sy4	62	24	cGAS	cgas	NN
cord-259748-x7dq1sy4	62	25	(	(	-LRB-
cord-259748-x7dq1sy4	62	26	20	20	CD
cord-259748-x7dq1sy4	62	27	,	,	,
cord-259748-x7dq1sy4	62	28	21	21	CD
cord-259748-x7dq1sy4	62	29	)	)	-RRB-
cord-259748-x7dq1sy4	62	30	(	(	-LRB-
cord-259748-x7dq1sy4	62	31	Figure	figure	NN
cord-259748-x7dq1sy4	62	32	1C	1c	NN
cord-259748-x7dq1sy4	62	33	)	)	-RRB-
cord-259748-x7dq1sy4	62	34	.	.	.
cord-259748-x7dq1sy4	63	1	Finally	finally	RB
cord-259748-x7dq1sy4	63	2	,	,	,
cord-259748-x7dq1sy4	63	3	accumulated	accumulate	VBN
cord-259748-x7dq1sy4	63	4	cGAS	cgas	NN
cord-259748-x7dq1sy4	63	5	-	-	HYPH
cord-259748-x7dq1sy4	63	6	dsDNA	dsdna	JJ
cord-259748-x7dq1sy4	63	7	complexes	complex	NNS
cord-259748-x7dq1sy4	63	8	can	can	MD
cord-259748-x7dq1sy4	63	9	go	go	VB
cord-259748-x7dq1sy4	63	10	through	through	IN
cord-259748-x7dq1sy4	63	11	a	a	DT
cord-259748-x7dq1sy4	63	12	liquid	liquid	JJ
cord-259748-x7dq1sy4	63	13	-	-	HYPH
cord-259748-x7dq1sy4	63	14	phase	phase	NN
cord-259748-x7dq1sy4	63	15	separation	separation	NN
cord-259748-x7dq1sy4	63	16	and	and	CC
cord-259748-x7dq1sy4	63	17	condense	condense	VB
cord-259748-x7dq1sy4	63	18	into	into	IN
cord-259748-x7dq1sy4	63	19	gellike	gellike	JJ
cord-259748-x7dq1sy4	63	20	droplets	droplet	NNS
cord-259748-x7dq1sy4	63	21	as	as	IN
cord-259748-x7dq1sy4	63	22	a	a	DT
cord-259748-x7dq1sy4	63	23	reaction	reaction	NN
cord-259748-x7dq1sy4	63	24	unit	unit	NN
cord-259748-x7dq1sy4	63	25	(	(	-LRB-
cord-259748-x7dq1sy4	63	26	Figure	figure	NN
cord-259748-x7dq1sy4	63	27	1D	1d	CD
cord-259748-x7dq1sy4	63	28	)	)	-RRB-
cord-259748-x7dq1sy4	63	29	.	.	.
cord-259748-x7dq1sy4	64	1	This	this	DT
cord-259748-x7dq1sy4	64	2	conformation	conformation	NN
cord-259748-x7dq1sy4	64	3	requires	require	VBZ
cord-259748-x7dq1sy4	64	4	a	a	DT
cord-259748-x7dq1sy4	64	5	sufficiently	sufficiently	RB
cord-259748-x7dq1sy4	64	6	long	long	JJ
cord-259748-x7dq1sy4	64	7	dsDNA	dsdna	JJ
cord-259748-x7dq1sy4	64	8	strand	strand	NN
cord-259748-x7dq1sy4	64	9	to	to	TO
cord-259748-x7dq1sy4	64	10	form	form	VB
cord-259748-x7dq1sy4	64	11	multivalent	multivalent	JJ
cord-259748-x7dq1sy4	64	12	interaction	interaction	NN
cord-259748-x7dq1sy4	64	13	positions	position	NNS
cord-259748-x7dq1sy4	64	14	,	,	,
cord-259748-x7dq1sy4	64	15	also	also	RB
cord-259748-x7dq1sy4	64	16	requires	require	VBZ
cord-259748-x7dq1sy4	64	17	the	the	DT
cord-259748-x7dq1sy4	64	18	function	function	NN
cord-259748-x7dq1sy4	64	19	of	of	IN
cord-259748-x7dq1sy4	64	20	the	the	DT
cord-259748-x7dq1sy4	64	21	N	n	CD
cord-259748-x7dq1sy4	64	22	-	-	HYPH
cord-259748-x7dq1sy4	64	23	terminal	terminal	JJ
cord-259748-x7dq1sy4	64	24	tail	tail	NN
cord-259748-x7dq1sy4	64	25	of	of	IN
cord-259748-x7dq1sy4	64	26	cGAS	cgas	NN
cord-259748-x7dq1sy4	64	27	and	and	CC
cord-259748-x7dq1sy4	64	28	a	a	DT
cord-259748-x7dq1sy4	64	29	recently	recently	RB
cord-259748-x7dq1sy4	64	30	discovered	discover	VBN
cord-259748-x7dq1sy4	64	31	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	64	32	-	-	HYPH
cord-259748-x7dq1sy4	64	33	binding	bind	VBG
cord-259748-x7dq1sy4	64	34	site	site	NN
cord-259748-x7dq1sy4	64	35	in	in	IN
cord-259748-x7dq1sy4	64	36	the	the	DT
cord-259748-x7dq1sy4	64	37	catalytic	catalytic	JJ
cord-259748-x7dq1sy4	64	38	domain	domain	NN
cord-259748-x7dq1sy4	64	39	of	of	IN
cord-259748-x7dq1sy4	64	40	cGAS	cgas	NN
cord-259748-x7dq1sy4	64	41	(	(	-LRB-
cord-259748-x7dq1sy4	64	42	site	site	NN
cord-259748-x7dq1sy4	64	43	C	C	NNP
cord-259748-x7dq1sy4	64	44	)	)	-RRB-
cord-259748-x7dq1sy4	64	45	(	(	-LRB-
cord-259748-x7dq1sy4	64	46	22	22	CD
cord-259748-x7dq1sy4	64	47	,	,	,
cord-259748-x7dq1sy4	64	48	23	23	CD
cord-259748-x7dq1sy4	64	49	)	)	-RRB-
cord-259748-x7dq1sy4	64	50	.	.	.
cord-259748-x7dq1sy4	65	1	Meanwhile	meanwhile	RB
cord-259748-x7dq1sy4	65	2	,	,	,
cord-259748-x7dq1sy4	65	3	the	the	DT
cord-259748-x7dq1sy4	65	4	N	n	CD
cord-259748-x7dq1sy4	65	5	-	-	HYPH
cord-259748-x7dq1sy4	65	6	terminal	terminal	JJ
cord-259748-x7dq1sy4	65	7	tail	tail	NN
cord-259748-x7dq1sy4	65	8	of	of	IN
cord-259748-x7dq1sy4	65	9	cGAS	cgas	NN
cord-259748-x7dq1sy4	65	10	mediates	mediate	VBZ
cord-259748-x7dq1sy4	65	11	cGAS	cgas	JJ
cord-259748-x7dq1sy4	65	12	localization	localization	NN
cord-259748-x7dq1sy4	65	13	onto	onto	IN
cord-259748-x7dq1sy4	65	14	the	the	DT
cord-259748-x7dq1sy4	65	15	membrane	membrane	NN
cord-259748-x7dq1sy4	65	16	by	by	IN
cord-259748-x7dq1sy4	65	17	binding	bind	VBG
cord-259748-x7dq1sy4	65	18	to	to	IN
cord-259748-x7dq1sy4	65	19	phosphatidylinositol	phosphatidylinositol	NN
cord-259748-x7dq1sy4	65	20	4,5bisphosphate	4,5bisphosphate	CD
cord-259748-x7dq1sy4	66	1	(	(	-LRB-
cord-259748-x7dq1sy4	66	2	PI	PI	NNP
cord-259748-x7dq1sy4	66	3	(	(	-LRB-
cord-259748-x7dq1sy4	66	4	4	4	CD
cord-259748-x7dq1sy4	66	5	,	,	,
cord-259748-x7dq1sy4	66	6	5	5	CD
cord-259748-x7dq1sy4	66	7	)	)	-RRB-
cord-259748-x7dq1sy4	66	8	P2	P2	NNP
cord-259748-x7dq1sy4	66	9	)	)	-RRB-
cord-259748-x7dq1sy4	66	10	and	and	CC
cord-259748-x7dq1sy4	66	11	prevents	prevent	VBZ
cord-259748-x7dq1sy4	66	12	liberation	liberation	NN
cord-259748-x7dq1sy4	66	13	of	of	IN
cord-259748-x7dq1sy4	66	14	cGAS	cgas	NN
cord-259748-x7dq1sy4	66	15	and	and	CC
cord-259748-x7dq1sy4	66	16	oligomerization	oligomerization	NN
cord-259748-x7dq1sy4	66	17	,	,	,
cord-259748-x7dq1sy4	66	18	but	but	CC
cord-259748-x7dq1sy4	66	19	can	can	MD
cord-259748-x7dq1sy4	66	20	release	release	VB
cord-259748-x7dq1sy4	66	21	cGAS	cgas	NN
cord-259748-x7dq1sy4	66	22	during	during	IN
cord-259748-x7dq1sy4	66	23	cell	cell	NN
cord-259748-x7dq1sy4	66	24	stress	stress	NN
cord-259748-x7dq1sy4	66	25	(	(	-LRB-
cord-259748-x7dq1sy4	66	26	24	24	CD
cord-259748-x7dq1sy4	66	27	)	)	-RRB-
cord-259748-x7dq1sy4	66	28	.	.	.
cord-259748-x7dq1sy4	67	1	The	the	DT
cord-259748-x7dq1sy4	67	2	structure	structure	NN
cord-259748-x7dq1sy4	67	3	of	of	IN
cord-259748-x7dq1sy4	67	4	cGAS	cgas	NN
cord-259748-x7dq1sy4	67	5	determines	determine	VBZ
cord-259748-x7dq1sy4	67	6	long	long	JJ
cord-259748-x7dq1sy4	67	7	strand	strand	NN
cord-259748-x7dq1sy4	67	8	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	68	1	(	(	-LRB-
cord-259748-x7dq1sy4	68	2	>	>	NFP
cord-259748-x7dq1sy4	68	3	500	500	CD
cord-259748-x7dq1sy4	68	4	-	-	SYM
cord-259748-x7dq1sy4	68	5	1,000	1,000	CD
cord-259748-x7dq1sy4	68	6	bp	bp	NNP
cord-259748-x7dq1sy4	68	7	)	)	-RRB-
cord-259748-x7dq1sy4	68	8	could	could	MD
cord-259748-x7dq1sy4	68	9	potentially	potentially	RB
cord-259748-x7dq1sy4	68	10	stimulate	stimulate	VB
cord-259748-x7dq1sy4	68	11	the	the	DT
cord-259748-x7dq1sy4	68	12	enzyme	enzyme	NN
cord-259748-x7dq1sy4	68	13	activity	activity	NN
cord-259748-x7dq1sy4	68	14	and	and	CC
cord-259748-x7dq1sy4	68	15	cGAMP	cgamp	NN
cord-259748-x7dq1sy4	68	16	production	production	NN
cord-259748-x7dq1sy4	68	17	of	of	IN
cord-259748-x7dq1sy4	68	18	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	68	19	(	(	-LRB-
cord-259748-x7dq1sy4	68	20	25	25	CD
cord-259748-x7dq1sy4	68	21	)	)	-RRB-
cord-259748-x7dq1sy4	68	22	.	.	.
cord-259748-x7dq1sy4	69	1	The	the	DT
cord-259748-x7dq1sy4	69	2	ability	ability	NN
cord-259748-x7dq1sy4	69	3	of	of	IN
cord-259748-x7dq1sy4	69	4	human	human	JJ
cord-259748-x7dq1sy4	69	5	cGAS	cgas	NN
cord-259748-x7dq1sy4	69	6	to	to	TO
cord-259748-x7dq1sy4	69	7	discriminate	discriminate	VB
cord-259748-x7dq1sy4	69	8	long	long	RB
cord-259748-x7dq1sy4	69	9	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	69	10	strands	strand	NNS
cord-259748-x7dq1sy4	69	11	from	from	IN
cord-259748-x7dq1sy4	69	12	shorter	short	JJR
cord-259748-x7dq1sy4	69	13	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	69	14	may	may	MD
cord-259748-x7dq1sy4	69	15	contribute	contribute	VB
cord-259748-x7dq1sy4	69	16	to	to	IN
cord-259748-x7dq1sy4	69	17	the	the	DT
cord-259748-x7dq1sy4	69	18	specific	specific	JJ
cord-259748-x7dq1sy4	69	19	sensing	sensing	NN
cord-259748-x7dq1sy4	69	20	and	and	CC
cord-259748-x7dq1sy4	69	21	recognition	recognition	NN
cord-259748-x7dq1sy4	69	22	of	of	IN
cord-259748-x7dq1sy4	69	23	the	the	DT
cord-259748-x7dq1sy4	69	24	"	"	``
cord-259748-x7dq1sy4	69	25	danger	danger	NN
cord-259748-x7dq1sy4	69	26	DNA	dna	NN
cord-259748-x7dq1sy4	69	27	"	"	''
cord-259748-x7dq1sy4	69	28	of	of	IN
cord-259748-x7dq1sy4	69	29	pathogens	pathogen	NNS
cord-259748-x7dq1sy4	69	30	,	,	,
cord-259748-x7dq1sy4	69	31	necrotic	necrotic	JJ
cord-259748-x7dq1sy4	69	32	cells	cell	NNS
cord-259748-x7dq1sy4	69	33	or	or	CC
cord-259748-x7dq1sy4	69	34	cancer	cancer	NN
cord-259748-x7dq1sy4	69	35	cells	cell	NNS
cord-259748-x7dq1sy4	69	36	rather	rather	RB
cord-259748-x7dq1sy4	69	37	than	than	IN
cord-259748-x7dq1sy4	69	38	irrelevant	irrelevant	RB
cord-259748-x7dq1sy4	69	39	shorter	short	JJR
cord-259748-x7dq1sy4	69	40	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	69	41	,	,	,
cord-259748-x7dq1sy4	69	42	thereby	thereby	RB
cord-259748-x7dq1sy4	69	43	enhancing	enhance	VBG
cord-259748-x7dq1sy4	69	44	the	the	DT
cord-259748-x7dq1sy4	69	45	immunity	immunity	NN
cord-259748-x7dq1sy4	69	46	against	against	IN
cord-259748-x7dq1sy4	69	47	them	-PRON-	PRP
cord-259748-x7dq1sy4	69	48	specifically	specifically	RB
cord-259748-x7dq1sy4	69	49	.	.	.
cord-259748-x7dq1sy4	70	1	Double	double	JJ
cord-259748-x7dq1sy4	70	2	-	-	HYPH
cord-259748-x7dq1sy4	70	3	stranded	strand	VBN
cord-259748-x7dq1sy4	70	4	DNA	dna	NN
cord-259748-x7dq1sy4	70	5	is	be	VBZ
cord-259748-x7dq1sy4	70	6	restricted	restrict	VBN
cord-259748-x7dq1sy4	70	7	into	into	IN
cord-259748-x7dq1sy4	70	8	the	the	DT
cord-259748-x7dq1sy4	70	9	nucleus	nucleus	NN
cord-259748-x7dq1sy4	70	10	or	or	CC
cord-259748-x7dq1sy4	70	11	mitochondria	mitochondrion	NNS
cord-259748-x7dq1sy4	70	12	and	and	CC
cord-259748-x7dq1sy4	70	13	is	be	VBZ
cord-259748-x7dq1sy4	70	14	rarely	rarely	RB
cord-259748-x7dq1sy4	70	15	present	present	JJ
cord-259748-x7dq1sy4	70	16	in	in	IN
cord-259748-x7dq1sy4	70	17	the	the	DT
cord-259748-x7dq1sy4	70	18	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	70	19	.	.	.
cord-259748-x7dq1sy4	71	1	Extrinsic	extrinsic	JJ
cord-259748-x7dq1sy4	71	2	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	71	3	from	from	IN
cord-259748-x7dq1sy4	71	4	pathogens	pathogen	NNS
cord-259748-x7dq1sy4	71	5	such	such	JJ
cord-259748-x7dq1sy4	71	6	as	as	IN
cord-259748-x7dq1sy4	71	7	viruses	virus	NNS
cord-259748-x7dq1sy4	71	8	,	,	,
cord-259748-x7dq1sy4	71	9	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	71	10	,	,	,
cord-259748-x7dq1sy4	71	11	transcellular	transcellular	JJ
cord-259748-x7dq1sy4	71	12	vesicles	vesicle	NNS
cord-259748-x7dq1sy4	71	13	or	or	CC
cord-259748-x7dq1sy4	71	14	rupture	rupture	NN
cord-259748-x7dq1sy4	71	15	of	of	IN
cord-259748-x7dq1sy4	71	16	dying	die	VBG
cord-259748-x7dq1sy4	71	17	cells	cell	NNS
cord-259748-x7dq1sy4	71	18	can	can	MD
cord-259748-x7dq1sy4	71	19	be	be	VB
cord-259748-x7dq1sy4	71	20	internalized	internalize	VBN
cord-259748-x7dq1sy4	71	21	into	into	IN
cord-259748-x7dq1sy4	71	22	the	the	DT
cord-259748-x7dq1sy4	71	23	cytosol	cytosol	NN
cord-259748-x7dq1sy4	71	24	in	in	IN
cord-259748-x7dq1sy4	71	25	several	several	JJ
cord-259748-x7dq1sy4	71	26	diverse	diverse	JJ
cord-259748-x7dq1sy4	71	27	ways	way	NNS
cord-259748-x7dq1sy4	71	28	(	(	-LRB-
cord-259748-x7dq1sy4	71	29	26	26	CD
cord-259748-x7dq1sy4	71	30	-	-	SYM
cord-259748-x7dq1sy4	71	31	28	28	CD
cord-259748-x7dq1sy4	71	32	)	)	-RRB-
cord-259748-x7dq1sy4	71	33	.	.	.
cord-259748-x7dq1sy4	72	1	These	these	DT
cord-259748-x7dq1sy4	72	2	extrinsic	extrinsic	JJ
cord-259748-x7dq1sy4	72	3	dsDNA	dsdna	JJ
cord-259748-x7dq1sy4	72	4	sources	source	NNS
cord-259748-x7dq1sy4	72	5	are	be	VBP
cord-259748-x7dq1sy4	72	6	engulfed	engulf	VBN
cord-259748-x7dq1sy4	72	7	by	by	IN
cord-259748-x7dq1sy4	72	8	endosome	endosome	NN
cord-259748-x7dq1sy4	72	9	through	through	IN
cord-259748-x7dq1sy4	72	10	phagocytosis	phagocytosis	NN
cord-259748-x7dq1sy4	72	11	and	and	CC
cord-259748-x7dq1sy4	72	12	digested	digest	VBN
cord-259748-x7dq1sy4	72	13	immediately	immediately	RB
cord-259748-x7dq1sy4	72	14	by	by	IN
cord-259748-x7dq1sy4	72	15	DNaseII	DNaseII	NNS
cord-259748-x7dq1sy4	72	16	when	when	WRB
cord-259748-x7dq1sy4	72	17	fusing	fuse	VBG
cord-259748-x7dq1sy4	72	18	with	with	IN
cord-259748-x7dq1sy4	72	19	lysosomes	lysosome	NNS
cord-259748-x7dq1sy4	72	20	(	(	-LRB-
cord-259748-x7dq1sy4	72	21	29	29	CD
cord-259748-x7dq1sy4	72	22	,	,	,
cord-259748-x7dq1sy4	72	23	30	30	CD
cord-259748-x7dq1sy4	72	24	)	)	-RRB-
cord-259748-x7dq1sy4	72	25	.	.	.
cord-259748-x7dq1sy4	73	1	However	however	RB
cord-259748-x7dq1sy4	73	2	,	,	,
cord-259748-x7dq1sy4	73	3	some	some	DT
cord-259748-x7dq1sy4	73	4	escaping	escape	VBG
cord-259748-x7dq1sy4	73	5	mechanisms	mechanism	NNS
cord-259748-x7dq1sy4	73	6	under	under	IN
cord-259748-x7dq1sy4	73	7	certain	certain	JJ
cord-259748-x7dq1sy4	73	8	conditions	condition	NNS
cord-259748-x7dq1sy4	73	9	could	could	MD
cord-259748-x7dq1sy4	73	10	help	help	VB
cord-259748-x7dq1sy4	73	11	protect	protect	VB
cord-259748-x7dq1sy4	73	12	them	-PRON-	PRP
cord-259748-x7dq1sy4	73	13	from	from	IN
cord-259748-x7dq1sy4	73	14	being	be	VBG
cord-259748-x7dq1sy4	73	15	degraded	degrade	VBN
cord-259748-x7dq1sy4	73	16	.	.	.
cord-259748-x7dq1sy4	74	1	For	for	IN
cord-259748-x7dq1sy4	74	2	example	example	NN
cord-259748-x7dq1sy4	74	3	,	,	,
cord-259748-x7dq1sy4	74	4	antimicrobial	antimicrobial	JJ
cord-259748-x7dq1sy4	74	5	peptide	peptide	NN
cord-259748-x7dq1sy4	74	6	LL37	LL37	NNP
cord-259748-x7dq1sy4	74	7	could	could	MD
cord-259748-x7dq1sy4	74	8	efficiently	efficiently	RB
cord-259748-x7dq1sy4	74	9	transports	transport	VBZ
cord-259748-x7dq1sy4	74	10	self	self	NN
cord-259748-x7dq1sy4	74	11	-	-	HYPH
cord-259748-x7dq1sy4	74	12	DNA	dna	NN
cord-259748-x7dq1sy4	74	13	from	from	IN
cord-259748-x7dq1sy4	74	14	endosome	endosome	NN
cord-259748-x7dq1sy4	74	15	into	into	IN
cord-259748-x7dq1sy4	74	16	cytosol	cytosol	NN
cord-259748-x7dq1sy4	74	17	of	of	IN
cord-259748-x7dq1sy4	74	18	monocytes	monocyte	NNS
cord-259748-x7dq1sy4	74	19	(	(	-LRB-
cord-259748-x7dq1sy4	74	20	28	28	CD
cord-259748-x7dq1sy4	74	21	)	)	-RRB-
cord-259748-x7dq1sy4	74	22	.	.	.
cord-259748-x7dq1sy4	75	1	Cell	cell	NN
cord-259748-x7dq1sy4	75	2	oxidative	oxidative	JJ
cord-259748-x7dq1sy4	75	3	stress	stress	NN
cord-259748-x7dq1sy4	75	4	can	can	MD
cord-259748-x7dq1sy4	75	5	lead	lead	VB
cord-259748-x7dq1sy4	75	6	to	to	IN
cord-259748-x7dq1sy4	75	7	phagosomal	phagosomal	NN
cord-259748-x7dq1sy4	75	8	acidification	acidification	NN
cord-259748-x7dq1sy4	75	9	delay	delay	NN
cord-259748-x7dq1sy4	75	10	and	and	CC
cord-259748-x7dq1sy4	75	11	probably	probably	RB
cord-259748-x7dq1sy4	75	12	release	release	VB
cord-259748-x7dq1sy4	75	13	endosome	endosome	NN
cord-259748-x7dq1sy4	75	14	context	context	NN
cord-259748-x7dq1sy4	75	15	including	include	VBG
cord-259748-x7dq1sy4	75	16	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	75	17	owing	owe	VBG
cord-259748-x7dq1sy4	75	18	to	to	IN
cord-259748-x7dq1sy4	75	19	increased	increase	VBN
cord-259748-x7dq1sy4	75	20	membrane	membrane	NN
cord-259748-x7dq1sy4	75	21	permeability	permeability	NN
cord-259748-x7dq1sy4	75	22	(	(	-LRB-
cord-259748-x7dq1sy4	75	23	27	27	CD
cord-259748-x7dq1sy4	75	24	,	,	,
cord-259748-x7dq1sy4	75	25	31	31	CD
cord-259748-x7dq1sy4	75	26	)	)	-RRB-
cord-259748-x7dq1sy4	75	27	.	.	.
cord-259748-x7dq1sy4	76	1	The	the	DT
cord-259748-x7dq1sy4	76	2	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	76	3	self	self	NN
cord-259748-x7dq1sy4	76	4	-	-	HYPH
cord-259748-x7dq1sy4	76	5	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	76	6	can	can	MD
cord-259748-x7dq1sy4	76	7	also	also	RB
cord-259748-x7dq1sy4	76	8	be	be	VB
cord-259748-x7dq1sy4	76	9	segregated	segregate	VBN
cord-259748-x7dq1sy4	76	10	inaccurately	inaccurately	RB
cord-259748-x7dq1sy4	76	11	and	and	CC
cord-259748-x7dq1sy4	76	12	released	release	VBN
cord-259748-x7dq1sy4	76	13	into	into	IN
cord-259748-x7dq1sy4	76	14	the	the	DT
cord-259748-x7dq1sy4	76	15	cytosol	cytosol	NN
cord-259748-x7dq1sy4	76	16	(	(	-LRB-
cord-259748-x7dq1sy4	76	17	32	32	CD
cord-259748-x7dq1sy4	76	18	,	,	,
cord-259748-x7dq1sy4	76	19	33	33	CD
cord-259748-x7dq1sy4	76	20	)	)	-RRB-
cord-259748-x7dq1sy4	76	21	.	.	.
cord-259748-x7dq1sy4	77	1	For	for	IN
cord-259748-x7dq1sy4	77	2	example	example	NN
cord-259748-x7dq1sy4	77	3	,	,	,
cord-259748-x7dq1sy4	77	4	genomic	genomic	JJ
cord-259748-x7dq1sy4	77	5	DNA	dna	NN
cord-259748-x7dq1sy4	77	6	(	(	-LRB-
cord-259748-x7dq1sy4	77	7	gDNA	gDNA	NNP
cord-259748-x7dq1sy4	77	8	)	)	-RRB-
cord-259748-x7dq1sy4	77	9	injury	injury	NN
cord-259748-x7dq1sy4	77	10	as	as	IN
cord-259748-x7dq1sy4	77	11	a	a	DT
cord-259748-x7dq1sy4	77	12	result	result	NN
cord-259748-x7dq1sy4	77	13	of	of	IN
cord-259748-x7dq1sy4	77	14	genotoxic	genotoxic	JJ
cord-259748-x7dq1sy4	77	15	stress	stress	NN
cord-259748-x7dq1sy4	77	16	and	and	CC
cord-259748-x7dq1sy4	77	17	DNA	dna	NN
cord-259748-x7dq1sy4	77	18	self	self	NN
cord-259748-x7dq1sy4	77	19	-	-	HYPH
cord-259748-x7dq1sy4	77	20	instability	instability	NN
cord-259748-x7dq1sy4	77	21	or	or	CC
cord-259748-x7dq1sy4	77	22	replication	replication	NN
cord-259748-x7dq1sy4	77	23	errors	error	NNS
cord-259748-x7dq1sy4	77	24	leads	lead	VBZ
cord-259748-x7dq1sy4	77	25	to	to	IN
cord-259748-x7dq1sy4	77	26	double	double	JJ
cord-259748-x7dq1sy4	77	27	-	-	HYPH
cord-259748-x7dq1sy4	77	28	strand	strand	NN
cord-259748-x7dq1sy4	77	29	breaks	break	NNS
cord-259748-x7dq1sy4	77	30	(	(	-LRB-
cord-259748-x7dq1sy4	77	31	DSBs	dsb	NNS
cord-259748-x7dq1sy4	77	32	)	)	-RRB-
cord-259748-x7dq1sy4	77	33	and	and	CC
cord-259748-x7dq1sy4	77	34	can	can	MD
cord-259748-x7dq1sy4	77	35	be	be	VB
cord-259748-x7dq1sy4	77	36	repaired	repair	VBN
cord-259748-x7dq1sy4	77	37	by	by	IN
cord-259748-x7dq1sy4	77	38	several	several	JJ
cord-259748-x7dq1sy4	77	39	ways	way	NNS
cord-259748-x7dq1sy4	77	40	(	(	-LRB-
cord-259748-x7dq1sy4	77	41	34	34	CD
cord-259748-x7dq1sy4	77	42	)	)	-RRB-
cord-259748-x7dq1sy4	77	43	.	.	.
cord-259748-x7dq1sy4	78	1	Impaired	impaired	JJ
cord-259748-x7dq1sy4	78	2	mediators	mediator	NNS
cord-259748-x7dq1sy4	78	3	of	of	IN
cord-259748-x7dq1sy4	78	4	DNA	dna	NN
cord-259748-x7dq1sy4	78	5	-	-	HYPH
cord-259748-x7dq1sy4	78	6	damage	damage	NN
cord-259748-x7dq1sy4	78	7	repair	repair	NN
cord-259748-x7dq1sy4	78	8	response	response	NN
cord-259748-x7dq1sy4	78	9	mediators	mediator	NNS
cord-259748-x7dq1sy4	78	10	,	,	,
cord-259748-x7dq1sy4	78	11	such	such	JJ
cord-259748-x7dq1sy4	78	12	as	as	IN
cord-259748-x7dq1sy4	78	13	ataxia	ataxia	NN
cord-259748-x7dq1sy4	78	14	telangiectasia	telangiectasia	NNP
cord-259748-x7dq1sy4	78	15	mutated	mutate	VBN
cord-259748-x7dq1sy4	78	16	(	(	-LRB-
cord-259748-x7dq1sy4	78	17	ATM)-RAD3	atm)-rad3	JJ
cord-259748-x7dq1sy4	78	18	,	,	,
cord-259748-x7dq1sy4	78	19	poly	poly	NNP
cord-259748-x7dq1sy4	78	20	ADPribose	ADPribose	NNP
cord-259748-x7dq1sy4	78	21	polymerase	polymerase	NN
cord-259748-x7dq1sy4	78	22	(	(	-LRB-
cord-259748-x7dq1sy4	78	23	PARP	PARP	NNP
cord-259748-x7dq1sy4	78	24	)	)	-RRB-
cord-259748-x7dq1sy4	78	25	and	and	CC
cord-259748-x7dq1sy4	78	26	breast	breast	NN
cord-259748-x7dq1sy4	78	27	cancer1/2	cancer1/2	.
cord-259748-x7dq1sy4	78	28	(	(	-LRB-
cord-259748-x7dq1sy4	78	29	BRCA1/2	BRCA1/2	NNP
cord-259748-x7dq1sy4	78	30	)	)	-RRB-
cord-259748-x7dq1sy4	78	31	Multiple	multiple	JJ
cord-259748-x7dq1sy4	78	32	cGAS	cgas	NN
cord-259748-x7dq1sy4	78	33	molecules	molecule	NNS
cord-259748-x7dq1sy4	78	34	can	can	MD
cord-259748-x7dq1sy4	78	35	bind	bind	VB
cord-259748-x7dq1sy4	78	36	two	two	CD
cord-259748-x7dq1sy4	78	37	double	double	RB
cord-259748-x7dq1sy4	78	38	-	-	HYPH
cord-259748-x7dq1sy4	78	39	stranded	strand	VBN
cord-259748-x7dq1sy4	78	40	DNAs	dna	NNS
cord-259748-x7dq1sy4	78	41	(	(	-LRB-
cord-259748-x7dq1sy4	78	42	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	78	43	)	)	-RRB-
cord-259748-x7dq1sy4	78	44	to	to	TO
cord-259748-x7dq1sy4	78	45	form	form	VB
cord-259748-x7dq1sy4	78	46	a	a	DT
cord-259748-x7dq1sy4	78	47	2n:2	2n:2	CD
cord-259748-x7dq1sy4	78	48	cGAS	cgas	NN
cord-259748-x7dq1sy4	78	49	:	:	:
cord-259748-x7dq1sy4	78	50	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	78	51	higher	higher	RBR
cord-259748-x7dq1sy4	78	52	-	-	HYPH
cord-259748-x7dq1sy4	78	53	ordered	order	VBN
cord-259748-x7dq1sy4	78	54	"	"	``
cord-259748-x7dq1sy4	78	55	ladder	ladder	NN
cord-259748-x7dq1sy4	78	56	-	-	HYPH
cord-259748-x7dq1sy4	78	57	like	like	JJ
cord-259748-x7dq1sy4	78	58	"	"	``
cord-259748-x7dq1sy4	78	59	oligomerization	oligomerization	NN
cord-259748-x7dq1sy4	78	60	.	.	.
cord-259748-x7dq1sy4	79	1	Mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	79	2	transcription	transcription	NN
cord-259748-x7dq1sy4	79	3	factor	factor	NN
cord-259748-x7dq1sy4	80	1	A	a	DT
cord-259748-x7dq1sy4	80	2	(	(	-LRB-
cord-259748-x7dq1sy4	80	3	TFAM	TFAM	NNP
cord-259748-x7dq1sy4	80	4	)	)	-RRB-
cord-259748-x7dq1sy4	80	5	can	can	MD
cord-259748-x7dq1sy4	80	6	bend	bend	VB
cord-259748-x7dq1sy4	80	7	the	the	DT
cord-259748-x7dq1sy4	80	8	dsDNA	dsdna	NN
cord-259748-x7dq1sy4	80	9	into	into	IN
cord-259748-x7dq1sy4	80	10	a	a	DT
cord-259748-x7dq1sy4	80	11	U	u	NN
cord-259748-x7dq1sy4	80	12	-	-	HYPH
cord-259748-x7dq1sy4	80	13	shaped	shape	VBN
cord-259748-x7dq1sy4	80	14	structure	structure	NN
cord-259748-x7dq1sy4	80	15	and	and	CC
cord-259748-x7dq1sy4	80	16	promote	promote	VB
cord-259748-x7dq1sy4	80	17	polymerization	polymerization	NN
cord-259748-x7dq1sy4	80	18	.	.	.
cord-259748-x7dq1sy4	81	1	(	(	-LRB-
cord-259748-x7dq1sy4	81	2	C	C	NNP
cord-259748-x7dq1sy4	81	3	)	)	-RRB-
cord-259748-x7dq1sy4	81	4	cGAS	cgas	NN
cord-259748-x7dq1sy4	81	5	can	can	MD
cord-259748-x7dq1sy4	81	6	recognize	recognize	VB
cord-259748-x7dq1sy4	81	7	B	b	NN
cord-259748-x7dq1sy4	81	8	-	-	HYPH
cord-259748-x7dq1sy4	81	9	type	type	NN
cord-259748-x7dq1sy4	81	10	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	81	11	.	.	.
cord-259748-x7dq1sy4	82	1	In	in	IN
cord-259748-x7dq1sy4	82	2	humans	human	NNS
cord-259748-x7dq1sy4	82	3	,	,	,
cord-259748-x7dq1sy4	82	4	the	the	DT
cord-259748-x7dq1sy4	82	5	cGAS	cgas	JJ
cord-259748-x7dq1sy4	82	6	DNA	dna	NN
cord-259748-x7dq1sy4	82	7	-	-	HYPH
cord-259748-x7dq1sy4	82	8	interfacing	interface	VBG
cord-259748-x7dq1sy4	82	9	residue	residue	NN
cord-259748-x7dq1sy4	82	10	of	of	IN
cord-259748-x7dq1sy4	82	11	site	site	NN
cord-259748-x7dq1sy4	82	12	A	a	NN
cord-259748-x7dq1sy4	82	13	loosens	loosen	VBZ
cord-259748-x7dq1sy4	82	14	the	the	DT
cord-259748-x7dq1sy4	82	15	interaction	interaction	NN
cord-259748-x7dq1sy4	82	16	of	of	IN
cord-259748-x7dq1sy4	82	17	dsDNA	dsdna	NN
cord-259748-x7dq1sy4	82	18	to	to	TO
cord-259748-x7dq1sy4	82	19	curve	curve	VB
cord-259748-x7dq1sy4	82	20	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	82	21	away	away	RB
cord-259748-x7dq1sy4	82	22	for	for	IN
cord-259748-x7dq1sy4	82	23	more	more	RBR
cord-259748-x7dq1sy4	82	24	convenient	convenient	JJ
cord-259748-x7dq1sy4	82	25	binding	binding	NN
cord-259748-x7dq1sy4	82	26	with	with	IN
cord-259748-x7dq1sy4	82	27	next	next	JJ
cord-259748-x7dq1sy4	82	28	adjacent	adjacent	JJ
cord-259748-x7dq1sy4	82	29	cGAS	cgas	NN
cord-259748-x7dq1sy4	82	30	.	.	.
cord-259748-x7dq1sy4	83	1	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	83	2	can	can	MD
cord-259748-x7dq1sy4	83	3	catalyze	catalyze	VB
cord-259748-x7dq1sy4	83	4	GTP	GTP	NNP
cord-259748-x7dq1sy4	83	5	and	and	CC
cord-259748-x7dq1sy4	83	6	ATP	ATP	NNP
cord-259748-x7dq1sy4	83	7	to	to	TO
cord-259748-x7dq1sy4	83	8	synthesize	synthesize	VB
cord-259748-x7dq1sy4	83	9	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	83	10	guanosine	guanosine	NN
cord-259748-x7dq1sy4	83	11	monophosphate	monophosphate	NN
cord-259748-x7dq1sy4	83	12	-	-	HYPH
cord-259748-x7dq1sy4	83	13	adenosine	adenosine	NN
cord-259748-x7dq1sy4	83	14	monophosphate	monophosphate	NN
cord-259748-x7dq1sy4	83	15	(	(	-LRB-
cord-259748-x7dq1sy4	83	16	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	83	17	)	)	-RRB-
cord-259748-x7dq1sy4	83	18	.	.	.
cord-259748-x7dq1sy4	84	1	The	the	DT
cord-259748-x7dq1sy4	84	2	N	n	CD
cord-259748-x7dq1sy4	84	3	-	-	HYPH
cord-259748-x7dq1sy4	84	4	terminal	terminal	NN
cord-259748-x7dq1sy4	84	5	tail	tail	NN
cord-259748-x7dq1sy4	84	6	binds	bind	VBZ
cord-259748-x7dq1sy4	84	7	to	to	IN
cord-259748-x7dq1sy4	84	8	the	the	DT
cord-259748-x7dq1sy4	84	9	cell	cell	NN
cord-259748-x7dq1sy4	84	10	membrane	membrane	NN
cord-259748-x7dq1sy4	84	11	,	,	,
cord-259748-x7dq1sy4	84	12	associating	associate	VBG
cord-259748-x7dq1sy4	84	13	with	with	IN
cord-259748-x7dq1sy4	84	14	phosphatidylinositol	phosphatidylinositol	JJ
cord-259748-x7dq1sy4	84	15	4,5-bisphosphate	4,5-bisphosphate	CD
cord-259748-x7dq1sy4	84	16	[	[	-LRB-
cord-259748-x7dq1sy4	84	17	PI	pi	NN
cord-259748-x7dq1sy4	84	18	(	(	-LRB-
cord-259748-x7dq1sy4	84	19	4,5)P2	4,5)p2	CD
cord-259748-x7dq1sy4	84	20	]	]	-RRB-
cord-259748-x7dq1sy4	84	21	.	.	.
cord-259748-x7dq1sy4	85	1	(	(	-LRB-
cord-259748-x7dq1sy4	85	2	D	D	NNP
cord-259748-x7dq1sy4	85	3	)	)	-RRB-
cord-259748-x7dq1sy4	85	4	Accumulation	accumulation	NN
cord-259748-x7dq1sy4	85	5	of	of	IN
cord-259748-x7dq1sy4	85	6	cGAS	cgas	JJ
cord-259748-x7dq1sy4	85	7	-	-	HYPH
cord-259748-x7dq1sy4	85	8	DNA	dna	NN
cord-259748-x7dq1sy4	85	9	complex	complex	NN
cord-259748-x7dq1sy4	85	10	goes	go	VBZ
cord-259748-x7dq1sy4	85	11	through	through	IN
cord-259748-x7dq1sy4	85	12	a	a	DT
cord-259748-x7dq1sy4	85	13	liquid	liquid	JJ
cord-259748-x7dq1sy4	85	14	-	-	HYPH
cord-259748-x7dq1sy4	85	15	phase	phase	NN
cord-259748-x7dq1sy4	85	16	separation	separation	NN
cord-259748-x7dq1sy4	85	17	and	and	CC
cord-259748-x7dq1sy4	85	18	condenses	condense	VBZ
cord-259748-x7dq1sy4	85	19	into	into	IN
cord-259748-x7dq1sy4	85	20	gel	gel	NN
cord-259748-x7dq1sy4	85	21	-	-	HYPH
cord-259748-x7dq1sy4	85	22	like	like	JJ
cord-259748-x7dq1sy4	85	23	droplets	droplet	NNS
cord-259748-x7dq1sy4	85	24	.	.	.
cord-259748-x7dq1sy4	86	1	are	be	VBP
cord-259748-x7dq1sy4	86	2	associated	associate	VBN
cord-259748-x7dq1sy4	86	3	with	with	IN
cord-259748-x7dq1sy4	86	4	persisting	persist	VBG
cord-259748-x7dq1sy4	86	5	DSBs	dsb	NNS
cord-259748-x7dq1sy4	86	6	and	and	CC
cord-259748-x7dq1sy4	86	7	accumulation	accumulation	NN
cord-259748-x7dq1sy4	86	8	of	of	IN
cord-259748-x7dq1sy4	86	9	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	86	10	DNA	dna	NN
cord-259748-x7dq1sy4	86	11	(	(	-LRB-
cord-259748-x7dq1sy4	86	12	35	35	CD
cord-259748-x7dq1sy4	86	13	-	-	SYM
cord-259748-x7dq1sy4	86	14	37	37	CD
cord-259748-x7dq1sy4	86	15	)	)	-RRB-
cord-259748-x7dq1sy4	86	16	.	.	.
cord-259748-x7dq1sy4	87	1	Extra	extra	JJ
cord-259748-x7dq1sy4	87	2	-	-	JJ
cord-259748-x7dq1sy4	87	3	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	87	4	micronuclei	micronuclei	NN
cord-259748-x7dq1sy4	87	5	formation	formation	NN
cord-259748-x7dq1sy4	87	6	during	during	IN
cord-259748-x7dq1sy4	87	7	mitosis	mitosis	NN
cord-259748-x7dq1sy4	87	8	is	be	VBZ
cord-259748-x7dq1sy4	87	9	a	a	DT
cord-259748-x7dq1sy4	87	10	source	source	NN
cord-259748-x7dq1sy4	87	11	of	of	IN
cord-259748-x7dq1sy4	87	12	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	87	13	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	87	14	caused	cause	VBN
cord-259748-x7dq1sy4	87	15	by	by	IN
cord-259748-x7dq1sy4	87	16	DSBs	dsb	NNS
cord-259748-x7dq1sy4	87	17	(	(	-LRB-
cord-259748-x7dq1sy4	87	18	32	32	CD
cord-259748-x7dq1sy4	87	19	,	,	,
cord-259748-x7dq1sy4	87	20	38	38	CD
cord-259748-x7dq1sy4	87	21	)	)	-RRB-
cord-259748-x7dq1sy4	87	22	.	.	.
cord-259748-x7dq1sy4	88	1	Followed	follow	VBN
cord-259748-x7dq1sy4	88	2	by	by	IN
cord-259748-x7dq1sy4	88	3	homologous	homologous	JJ
cord-259748-x7dq1sy4	88	4	recombination	recombination	NN
cord-259748-x7dq1sy4	88	5	repair	repair	NN
cord-259748-x7dq1sy4	88	6	of	of	IN
cord-259748-x7dq1sy4	88	7	collapsed	collapse	VBN
cord-259748-x7dq1sy4	88	8	replication	replication	NN
cord-259748-x7dq1sy4	88	9	forks	fork	NNS
cord-259748-x7dq1sy4	88	10	,	,	,
cord-259748-x7dq1sy4	88	11	DNA	dna	NN
cord-259748-x7dq1sy4	88	12	cleavage	cleavage	NN
cord-259748-x7dq1sy4	88	13	by	by	IN
cord-259748-x7dq1sy4	88	14	methyl	methyl	NN
cord-259748-x7dq1sy4	88	15	methanesulphonate	methanesulphonate	NN
cord-259748-x7dq1sy4	88	16	(	(	-LRB-
cord-259748-x7dq1sy4	88	17	MMS	MMS	NNP
cord-259748-x7dq1sy4	88	18	)	)	-RRB-
cord-259748-x7dq1sy4	88	19	and	and	CC
cord-259748-x7dq1sy4	88	20	ultraviolet	ultraviolet	NN
cord-259748-x7dq1sy4	88	21	-	-	HYPH
cord-259748-x7dq1sy4	88	22	sensitive	sensitive	JJ
cord-259748-x7dq1sy4	88	23	81	81	CD
cord-259748-x7dq1sy4	88	24	(	(	-LRB-
cord-259748-x7dq1sy4	88	25	MUS81	MUS81	NNS
cord-259748-x7dq1sy4	88	26	)	)	-RRB-
cord-259748-x7dq1sy4	88	27	also	also	RB
cord-259748-x7dq1sy4	88	28	lead	lead	VBP
cord-259748-x7dq1sy4	88	29	to	to	IN
cord-259748-x7dq1sy4	88	30	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	88	31	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	88	32	presenting	present	VBG
cord-259748-x7dq1sy4	88	33	(	(	-LRB-
cord-259748-x7dq1sy4	88	34	39	39	CD
cord-259748-x7dq1sy4	88	35	)	)	-RRB-
cord-259748-x7dq1sy4	88	36	.	.	.
cord-259748-x7dq1sy4	89	1	Furthermore	furthermore	RB
cord-259748-x7dq1sy4	89	2	,	,	,
cord-259748-x7dq1sy4	89	3	manually	manually	RB
cord-259748-x7dq1sy4	89	4	Cre	Cre	NNP
cord-259748-x7dq1sy4	89	5	/	/	SYM
cord-259748-x7dq1sy4	89	6	loxP	loxP	NNP
cord-259748-x7dq1sy4	89	7	recombination	recombination	NN
cord-259748-x7dq1sy4	89	8	technology	technology	NN
cord-259748-x7dq1sy4	89	9	can	can	MD
cord-259748-x7dq1sy4	89	10	induce	induce	VB
cord-259748-x7dq1sy4	89	11	dsDNA	dsdna	JJ
cord-259748-x7dq1sy4	89	12	damage	damage	NN
cord-259748-x7dq1sy4	89	13	during	during	IN
cord-259748-x7dq1sy4	89	14	DNA	dna	NN
cord-259748-x7dq1sy4	89	15	cleavage	cleavage	NN
cord-259748-x7dq1sy4	89	16	,	,	,
cord-259748-x7dq1sy4	89	17	which	which	WDT
cord-259748-x7dq1sy4	89	18	results	result	VBZ
cord-259748-x7dq1sy4	89	19	in	in	IN
cord-259748-x7dq1sy4	89	20	the	the	DT
cord-259748-x7dq1sy4	89	21	accumulation	accumulation	NN
cord-259748-x7dq1sy4	89	22	of	of	IN
cord-259748-x7dq1sy4	89	23	cytoplasmic	cytoplasmic	JJ
cord-259748-x7dq1sy4	89	24	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	90	1	(	(	-LRB-
cord-259748-x7dq1sy4	90	2	40	40	CD
cord-259748-x7dq1sy4	90	3	)	)	-RRB-
cord-259748-x7dq1sy4	90	4	.	.	.
cord-259748-x7dq1sy4	91	1	In	in	IN
cord-259748-x7dq1sy4	91	2	normal	normal	JJ
cord-259748-x7dq1sy4	91	3	cellular	cellular	JJ
cord-259748-x7dq1sy4	91	4	mitotic	mitotic	JJ
cord-259748-x7dq1sy4	91	5	processes	process	NNS
cord-259748-x7dq1sy4	91	6	,	,	,
cord-259748-x7dq1sy4	91	7	chromosomal	chromosomal	JJ
cord-259748-x7dq1sy4	91	8	DNA	dna	NN
cord-259748-x7dq1sy4	91	9	can	can	MD
cord-259748-x7dq1sy4	91	10	be	be	VB
cord-259748-x7dq1sy4	91	11	exposed	expose	VBN
cord-259748-x7dq1sy4	91	12	to	to	IN
cord-259748-x7dq1sy4	91	13	the	the	DT
cord-259748-x7dq1sy4	91	14	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	91	15	,	,	,
cord-259748-x7dq1sy4	91	16	while	while	IN
cord-259748-x7dq1sy4	91	17	it	-PRON-	PRP
cord-259748-x7dq1sy4	91	18	is	be	VBZ
cord-259748-x7dq1sy4	91	19	hard	hard	JJ
cord-259748-x7dq1sy4	91	20	to	to	TO
cord-259748-x7dq1sy4	91	21	bind	bind	VB
cord-259748-x7dq1sy4	91	22	and	and	CC
cord-259748-x7dq1sy4	91	23	trigger	trigger	VB
cord-259748-x7dq1sy4	91	24	cGAS	cgas	NN
cord-259748-x7dq1sy4	91	25	(	(	-LRB-
cord-259748-x7dq1sy4	91	26	41	41	CD
cord-259748-x7dq1sy4	91	27	)	)	-RRB-
cord-259748-x7dq1sy4	91	28	.	.	.
cord-259748-x7dq1sy4	92	1	In	in	IN
cord-259748-x7dq1sy4	92	2	addition	addition	NN
cord-259748-x7dq1sy4	92	3	,	,	,
cord-259748-x7dq1sy4	92	4	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	92	5	DNA	dna	NN
cord-259748-x7dq1sy4	92	6	(	(	-LRB-
cord-259748-x7dq1sy4	92	7	mtDNA	mtDNA	NNP
cord-259748-x7dq1sy4	92	8	)	)	-RRB-
cord-259748-x7dq1sy4	92	9	is	be	VBZ
cord-259748-x7dq1sy4	92	10	also	also	RB
cord-259748-x7dq1sy4	92	11	a	a	DT
cord-259748-x7dq1sy4	92	12	considerable	considerable	JJ
cord-259748-x7dq1sy4	92	13	ligand	ligand	NN
cord-259748-x7dq1sy4	92	14	of	of	IN
cord-259748-x7dq1sy4	92	15	cGAS	cgas	NN
cord-259748-x7dq1sy4	92	16	and	and	CC
cord-259748-x7dq1sy4	92	17	can	can	MD
cord-259748-x7dq1sy4	92	18	be	be	VB
cord-259748-x7dq1sy4	92	19	released	release	VBN
cord-259748-x7dq1sy4	92	20	into	into	IN
cord-259748-x7dq1sy4	92	21	the	the	DT
cord-259748-x7dq1sy4	92	22	cytosol	cytosol	NN
cord-259748-x7dq1sy4	92	23	under	under	IN
cord-259748-x7dq1sy4	92	24	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	92	25	stress	stress	NN
cord-259748-x7dq1sy4	92	26	or	or	CC
cord-259748-x7dq1sy4	92	27	dysfunction	dysfunction	NN
cord-259748-x7dq1sy4	92	28	of	of	IN
cord-259748-x7dq1sy4	92	29	proteins	protein	NNS
cord-259748-x7dq1sy4	92	30	which	which	WDT
cord-259748-x7dq1sy4	92	31	participates	participate	VBZ
cord-259748-x7dq1sy4	92	32	in	in	IN
cord-259748-x7dq1sy4	92	33	maintaining	maintain	VBG
cord-259748-x7dq1sy4	92	34	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	92	35	operations	operation	NNS
cord-259748-x7dq1sy4	92	36	(	(	-LRB-
cord-259748-x7dq1sy4	92	37	33	33	CD
cord-259748-x7dq1sy4	92	38	,	,	,
cord-259748-x7dq1sy4	92	39	42	42	CD
cord-259748-x7dq1sy4	92	40	,	,	,
cord-259748-x7dq1sy4	92	41	43	43	CD
cord-259748-x7dq1sy4	92	42	)	)	-RRB-
cord-259748-x7dq1sy4	93	1	(	(	-LRB-
cord-259748-x7dq1sy4	93	2	Figure	figure	NN
cord-259748-x7dq1sy4	93	3	2A	2a	CD
cord-259748-x7dq1sy4	93	4	)	)	-RRB-
cord-259748-x7dq1sy4	93	5	.	.	.
cord-259748-x7dq1sy4	94	1	Cells	cell	NNS
cord-259748-x7dq1sy4	94	2	have	have	VBP
cord-259748-x7dq1sy4	94	3	several	several	JJ
cord-259748-x7dq1sy4	94	4	types	type	NNS
cord-259748-x7dq1sy4	94	5	of	of	IN
cord-259748-x7dq1sy4	94	6	nucleases	nuclease	NNS
cord-259748-x7dq1sy4	94	7	to	to	TO
cord-259748-x7dq1sy4	94	8	restrict	restrict	VB
cord-259748-x7dq1sy4	94	9	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	94	10	DNA	dna	NN
cord-259748-x7dq1sy4	94	11	to	to	TO
cord-259748-x7dq1sy4	94	12	avoid	avoid	VB
cord-259748-x7dq1sy4	94	13	cGAS	cgas	JJ
cord-259748-x7dq1sy4	94	14	activation	activation	NN
cord-259748-x7dq1sy4	94	15	.	.	.
cord-259748-x7dq1sy4	95	1	For	for	IN
cord-259748-x7dq1sy4	95	2	example	example	NN
cord-259748-x7dq1sy4	95	3	,	,	,
cord-259748-x7dq1sy4	95	4	three	three	CD
cord-259748-x7dq1sy4	95	5	-	-	HYPH
cord-259748-x7dq1sy4	95	6	prime	prime	NN
cord-259748-x7dq1sy4	95	7	repair	repair	NN
cord-259748-x7dq1sy4	95	8	exonuclease	exonuclease	NN
cord-259748-x7dq1sy4	95	9	1	1	CD
cord-259748-x7dq1sy4	95	10	(	(	-LRB-
cord-259748-x7dq1sy4	95	11	TREX1	TREX1	NNP
cord-259748-x7dq1sy4	95	12	also	also	RB
cord-259748-x7dq1sy4	95	13	known	know	VBN
cord-259748-x7dq1sy4	95	14	as	as	IN
cord-259748-x7dq1sy4	95	15	DNaseIII	DNaseIII	NNP
cord-259748-x7dq1sy4	95	16	)	)	-RRB-
cord-259748-x7dq1sy4	95	17	is	be	VBZ
cord-259748-x7dq1sy4	95	18	a	a	DT
cord-259748-x7dq1sy4	95	19	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	95	20	DNA	dna	NN
cord-259748-x7dq1sy4	95	21	exonuclease	exonuclease	NN
cord-259748-x7dq1sy4	95	22	which	which	WDT
cord-259748-x7dq1sy4	95	23	removes	remove	VBZ
cord-259748-x7dq1sy4	95	24	unprotected	unprotected	JJ
cord-259748-x7dq1sy4	95	25	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	95	26	from	from	IN
cord-259748-x7dq1sy4	95	27	the	the	DT
cord-259748-x7dq1sy4	95	28	cytosol	cytosol	NN
cord-259748-x7dq1sy4	95	29	(	(	-LRB-
cord-259748-x7dq1sy4	95	30	44	44	CD
cord-259748-x7dq1sy4	95	31	)	)	-RRB-
cord-259748-x7dq1sy4	95	32	.	.	.
cord-259748-x7dq1sy4	96	1	RNaseH2	RNaseH2	NNP
cord-259748-x7dq1sy4	96	2	locates	locate	VBZ
cord-259748-x7dq1sy4	96	3	to	to	IN
cord-259748-x7dq1sy4	96	4	the	the	DT
cord-259748-x7dq1sy4	96	5	nucleus	nucleus	NN
cord-259748-x7dq1sy4	96	6	and	and	CC
cord-259748-x7dq1sy4	96	7	specifically	specifically	RB
cord-259748-x7dq1sy4	96	8	degrades	degrade	VBZ
cord-259748-x7dq1sy4	96	9	the	the	DT
cord-259748-x7dq1sy4	96	10	RNA	RNA	NNP
cord-259748-x7dq1sy4	96	11	in	in	IN
cord-259748-x7dq1sy4	96	12	RNA	RNA	NNP
cord-259748-x7dq1sy4	96	13	:	:	:
cord-259748-x7dq1sy4	96	14	DNA	dna	NN
cord-259748-x7dq1sy4	96	15	hybrids	hybrid	NNS
cord-259748-x7dq1sy4	96	16	participating	participate	VBG
cord-259748-x7dq1sy4	96	17	in	in	IN
cord-259748-x7dq1sy4	96	18	DNA	dna	NN
cord-259748-x7dq1sy4	96	19	replication	replication	NN
cord-259748-x7dq1sy4	96	20	(	(	-LRB-
cord-259748-x7dq1sy4	96	21	45	45	CD
cord-259748-x7dq1sy4	96	22	)	)	-RRB-
cord-259748-x7dq1sy4	96	23	.	.	.
cord-259748-x7dq1sy4	97	1	DNaseII	DNaseII	NNP
cord-259748-x7dq1sy4	97	2	is	be	VBZ
cord-259748-x7dq1sy4	97	3	a	a	DT
cord-259748-x7dq1sy4	97	4	lysosomal	lysosomal	JJ
cord-259748-x7dq1sy4	97	5	DNase	dnase	XX
cord-259748-x7dq1sy4	97	6	which	which	WDT
cord-259748-x7dq1sy4	97	7	degrades	degrade	VBZ
cord-259748-x7dq1sy4	97	8	undigested	undigested	JJ
cord-259748-x7dq1sy4	97	9	DNA	dna	NN
cord-259748-x7dq1sy4	97	10	in	in	IN
cord-259748-x7dq1sy4	97	11	endosomes	endosome	NNS
cord-259748-x7dq1sy4	97	12	or	or	CC
cord-259748-x7dq1sy4	97	13	autophagosomes	autophagosome	NNS
cord-259748-x7dq1sy4	97	14	to	to	TO
cord-259748-x7dq1sy4	97	15	prevent	prevent	VB
cord-259748-x7dq1sy4	97	16	their	-PRON-	PRP$
cord-259748-x7dq1sy4	97	17	entry	entry	NN
cord-259748-x7dq1sy4	97	18	into	into	IN
cord-259748-x7dq1sy4	97	19	the	the	DT
cord-259748-x7dq1sy4	97	20	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	97	21	(	(	-LRB-
cord-259748-x7dq1sy4	97	22	30	30	CD
cord-259748-x7dq1sy4	97	23	)	)	-RRB-
cord-259748-x7dq1sy4	97	24	.	.	.
cord-259748-x7dq1sy4	98	1	SAM	SAM	NNP
cord-259748-x7dq1sy4	98	2	domain	domain	NN
cord-259748-x7dq1sy4	98	3	and	and	CC
cord-259748-x7dq1sy4	98	4	HD	hd	NN
cord-259748-x7dq1sy4	98	5	domain	domain	NN
cord-259748-x7dq1sy4	98	6	-	-	HYPH
cord-259748-x7dq1sy4	98	7	containing	contain	VBG
cord-259748-x7dq1sy4	98	8	protein	protein	NN
cord-259748-x7dq1sy4	98	9	1	1	CD
cord-259748-x7dq1sy4	98	10	(	(	-LRB-
cord-259748-x7dq1sy4	98	11	SAMHD1	SAMHD1	NNS
cord-259748-x7dq1sy4	98	12	)	)	-RRB-
cord-259748-x7dq1sy4	98	13	is	be	VBZ
cord-259748-x7dq1sy4	98	14	characterized	characterize	VBN
cord-259748-x7dq1sy4	98	15	as	as	IN
cord-259748-x7dq1sy4	98	16	a	a	DT
cord-259748-x7dq1sy4	98	17	dNTPase	dntpase	NN
cord-259748-x7dq1sy4	98	18	and	and	CC
cord-259748-x7dq1sy4	98	19	restricts	restrict	VBZ
cord-259748-x7dq1sy4	98	20	reverse	reverse	JJ
cord-259748-x7dq1sy4	98	21	transcription	transcription	NN
cord-259748-x7dq1sy4	98	22	of	of	IN
cord-259748-x7dq1sy4	98	23	the	the	DT
cord-259748-x7dq1sy4	98	24	RNA	RNA	NNP
cord-259748-x7dq1sy4	98	25	virus	virus	NN
cord-259748-x7dq1sy4	98	26	(	(	-LRB-
cord-259748-x7dq1sy4	98	27	46	46	CD
cord-259748-x7dq1sy4	98	28	,	,	,
cord-259748-x7dq1sy4	98	29	47	47	CD
cord-259748-x7dq1sy4	98	30	)	)	-RRB-
cord-259748-x7dq1sy4	98	31	.	.	.
cord-259748-x7dq1sy4	99	1	SAMHD1	SAMHD1	NNS
cord-259748-x7dq1sy4	99	2	can	can	MD
cord-259748-x7dq1sy4	99	3	also	also	RB
cord-259748-x7dq1sy4	99	4	stimulate	stimulate	VB
cord-259748-x7dq1sy4	99	5	the	the	DT
cord-259748-x7dq1sy4	99	6	exonuclease	exonuclease	NN
cord-259748-x7dq1sy4	99	7	(	(	-LRB-
cord-259748-x7dq1sy4	99	8	but	but	CC
cord-259748-x7dq1sy4	99	9	not	not	RB
cord-259748-x7dq1sy4	99	10	the	the	DT
cord-259748-x7dq1sy4	99	11	endonuclease	endonuclease	NN
cord-259748-x7dq1sy4	99	12	)	)	-RRB-
cord-259748-x7dq1sy4	99	13	activity	activity	NN
cord-259748-x7dq1sy4	99	14	of	of	IN
cord-259748-x7dq1sy4	99	15	MRE11	MRE11	NNP
cord-259748-x7dq1sy4	99	16	to	to	TO
cord-259748-x7dq1sy4	99	17	degrade	degrade	VB
cord-259748-x7dq1sy4	99	18	nascent	nascent	JJ
cord-259748-x7dq1sy4	99	19	CDNs	cdn	NNS
cord-259748-x7dq1sy4	99	20	(	(	-LRB-
cord-259748-x7dq1sy4	99	21	including	include	VBG
cord-259748-x7dq1sy4	99	22	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	99	23	)	)	-RRB-
cord-259748-x7dq1sy4	99	24	might	may	MD
cord-259748-x7dq1sy4	99	25	be	be	VB
cord-259748-x7dq1sy4	99	26	exported	export	VBN
cord-259748-x7dq1sy4	99	27	by	by	IN
cord-259748-x7dq1sy4	99	28	some	some	DT
cord-259748-x7dq1sy4	99	29	ways	way	NNS
cord-259748-x7dq1sy4	99	30	.	.	.
cord-259748-x7dq1sy4	100	1	(	(	-LRB-
cord-259748-x7dq1sy4	100	2	C	C	NNP
cord-259748-x7dq1sy4	100	3	)	)	-RRB-
cord-259748-x7dq1sy4	100	4	Inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	100	5	signaling	signal	VBG
cord-259748-x7dq1sy4	100	6	mediated	mediate	VBN
cord-259748-x7dq1sy4	100	7	by	by	IN
cord-259748-x7dq1sy4	100	8	the	the	DT
cord-259748-x7dq1sy4	100	9	cGAS	cgas	JJ
cord-259748-x7dq1sy4	100	10	-	-	HYPH
cord-259748-x7dq1sy4	100	11	STING	sting	NN
cord-259748-x7dq1sy4	100	12	pathway	pathway	NN
cord-259748-x7dq1sy4	100	13	.	.	.
cord-259748-x7dq1sy4	101	1	After	after	IN
cord-259748-x7dq1sy4	101	2	sensing	sense	VBG
cord-259748-x7dq1sy4	101	3	DNA	dna	NN
cord-259748-x7dq1sy4	101	4	,	,	,
cord-259748-x7dq1sy4	101	5	cGAS	cgas	NN
cord-259748-x7dq1sy4	101	6	produces	produce	VBZ
cord-259748-x7dq1sy4	101	7	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	101	8	and	and	CC
cord-259748-x7dq1sy4	101	9	extracellular	extracellular	JJ
cord-259748-x7dq1sy4	101	10	CDNs	cdn	NNS
cord-259748-x7dq1sy4	101	11	,	,	,
cord-259748-x7dq1sy4	101	12	promoting	promote	VBG
cord-259748-x7dq1sy4	101	13	stimulator	stimulator	NN
cord-259748-x7dq1sy4	101	14	of	of	IN
cord-259748-x7dq1sy4	101	15	interferon	interferon	NN
cord-259748-x7dq1sy4	101	16	genes	gene	NNS
cord-259748-x7dq1sy4	101	17	(	(	-LRB-
cord-259748-x7dq1sy4	101	18	STING	sting	VB
cord-259748-x7dq1sy4	101	19	)	)	-RRB-
cord-259748-x7dq1sy4	101	20	to	to	TO
cord-259748-x7dq1sy4	101	21	undergo	undergo	VB
cord-259748-x7dq1sy4	101	22	dimerization	dimerization	NN
cord-259748-x7dq1sy4	101	23	.	.	.
cord-259748-x7dq1sy4	102	1	STING	STING	NNP
cord-259748-x7dq1sy4	102	2	can	can	MD
cord-259748-x7dq1sy4	102	3	exit	exit	VB
cord-259748-x7dq1sy4	102	4	from	from	IN
cord-259748-x7dq1sy4	102	5	the	the	DT
cord-259748-x7dq1sy4	102	6	endoplasmic	endoplasmic	NN
cord-259748-x7dq1sy4	102	7	reticulum	reticulum	NN
cord-259748-x7dq1sy4	102	8	(	(	-LRB-
cord-259748-x7dq1sy4	102	9	ER	ER	NNP
cord-259748-x7dq1sy4	102	10	)	)	-RRB-
cord-259748-x7dq1sy4	102	11	,	,	,
cord-259748-x7dq1sy4	102	12	and	and	CC
cord-259748-x7dq1sy4	102	13	be	be	VB
cord-259748-x7dq1sy4	102	14	translocated	translocate	VBN
cord-259748-x7dq1sy4	102	15	from	from	IN
cord-259748-x7dq1sy4	102	16	the	the	DT
cord-259748-x7dq1sy4	102	17	ER	ER	NNP
cord-259748-x7dq1sy4	102	18	to	to	IN
cord-259748-x7dq1sy4	102	19	the	the	DT
cord-259748-x7dq1sy4	102	20	ER	ER	NNP
cord-259748-x7dq1sy4	102	21	-	-	HYPH
cord-259748-x7dq1sy4	102	22	Golgi	Golgi	NNP
cord-259748-x7dq1sy4	102	23	vesicle	vesicle	NN
cord-259748-x7dq1sy4	102	24	,	,	,
cord-259748-x7dq1sy4	102	25	and	and	CC
cord-259748-x7dq1sy4	102	26	arrives	arrive	VBZ
cord-259748-x7dq1sy4	102	27	at	at	IN
cord-259748-x7dq1sy4	102	28	the	the	DT
cord-259748-x7dq1sy4	102	29	Golgi	Golgi	NNP
cord-259748-x7dq1sy4	102	30	.	.	.
cord-259748-x7dq1sy4	103	1	STING	STING	NNP
cord-259748-x7dq1sy4	103	2	and	and	CC
cord-259748-x7dq1sy4	103	3	TANK	tank	NN
cord-259748-x7dq1sy4	103	4	binding	binding	NN
cord-259748-x7dq1sy4	103	5	kinase	kinase	NN
cord-259748-x7dq1sy4	103	6	1	1	CD
cord-259748-x7dq1sy4	103	7	(	(	-LRB-
cord-259748-x7dq1sy4	103	8	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	103	9	)	)	-RRB-
cord-259748-x7dq1sy4	103	10	can	can	MD
cord-259748-x7dq1sy4	103	11	be	be	VB
cord-259748-x7dq1sy4	103	12	oligomerized	oligomerize	VBN
cord-259748-x7dq1sy4	103	13	and	and	CC
cord-259748-x7dq1sy4	103	14	cluster	cluster	NN
cord-259748-x7dq1sy4	103	15	at	at	IN
cord-259748-x7dq1sy4	103	16	the	the	DT
cord-259748-x7dq1sy4	103	17	Golgi	Golgi	NNP
cord-259748-x7dq1sy4	103	18	.	.	.
cord-259748-x7dq1sy4	104	1	The	the	DT
cord-259748-x7dq1sy4	104	2	STING	STING	NNP
cord-259748-x7dq1sy4	104	3	-	-	HYPH
cord-259748-x7dq1sy4	104	4	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	104	5	/	/	SYM
cord-259748-x7dq1sy4	104	6	IκB	iκb	NN
cord-259748-x7dq1sy4	104	7	kinase	kinase	NN
cord-259748-x7dq1sy4	104	8	(	(	-LRB-
cord-259748-x7dq1sy4	104	9	IKK	IKK	NNP
cord-259748-x7dq1sy4	104	10	)	)	-RRB-
cord-259748-x7dq1sy4	104	11	signalosome	signalosome	NNP
cord-259748-x7dq1sy4	104	12	forms	form	VBZ
cord-259748-x7dq1sy4	104	13	a	a	DT
cord-259748-x7dq1sy4	104	14	scaffold	scaffold	NN
cord-259748-x7dq1sy4	104	15	to	to	TO
cord-259748-x7dq1sy4	104	16	phosphorylate	phosphorylate	VB
cord-259748-x7dq1sy4	104	17	interferon	interferon	NN
cord-259748-x7dq1sy4	104	18	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	104	19	factor	factor	NN
cord-259748-x7dq1sy4	104	20	3	3	CD
cord-259748-x7dq1sy4	104	21	(	(	-LRB-
cord-259748-x7dq1sy4	104	22	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	104	23	)	)	-RRB-
cord-259748-x7dq1sy4	104	24	and	and	CC
cord-259748-x7dq1sy4	104	25	inhibitor	inhibitor	NN
cord-259748-x7dq1sy4	104	26	of	of	IN
cord-259748-x7dq1sy4	104	27	NF	nf	NN
cord-259748-x7dq1sy4	104	28	-	-	HYPH
cord-259748-x7dq1sy4	104	29	κBα	κBα	NNP
cord-259748-x7dq1sy4	104	30	(	(	-LRB-
cord-259748-x7dq1sy4	104	31	IκBα	IκBα	NNP
cord-259748-x7dq1sy4	104	32	)	)	-RRB-
cord-259748-x7dq1sy4	104	33	.	.	.
cord-259748-x7dq1sy4	105	1	Then	then	RB
cord-259748-x7dq1sy4	105	2	,	,	,
cord-259748-x7dq1sy4	105	3	dimerized	dimerize	VBD
cord-259748-x7dq1sy4	105	4	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	105	5	and	and	CC
cord-259748-x7dq1sy4	105	6	the	the	DT
cord-259748-x7dq1sy4	105	7	activated	activate	VBN
cord-259748-x7dq1sy4	105	8	canonical	canonical	JJ
cord-259748-x7dq1sy4	105	9	NF	nf	NN
cord-259748-x7dq1sy4	105	10	-	-	HYPH
cord-259748-x7dq1sy4	105	11	κB	κb	CD
cord-259748-x7dq1sy4	105	12	p50	p50	NN
cord-259748-x7dq1sy4	105	13	/	/	SYM
cord-259748-x7dq1sy4	105	14	p65	p65	NN
cord-259748-x7dq1sy4	105	15	complex	complex	NN
cord-259748-x7dq1sy4	105	16	can	can	MD
cord-259748-x7dq1sy4	105	17	be	be	VB
cord-259748-x7dq1sy4	105	18	translocated	translocate	VBN
cord-259748-x7dq1sy4	105	19	into	into	IN
cord-259748-x7dq1sy4	105	20	the	the	DT
cord-259748-x7dq1sy4	105	21	nucleus	nucleus	NN
cord-259748-x7dq1sy4	105	22	as	as	IN
cord-259748-x7dq1sy4	105	23	transcription	transcription	NN
cord-259748-x7dq1sy4	105	24	factors	factor	NNS
cord-259748-x7dq1sy4	105	25	to	to	TO
cord-259748-x7dq1sy4	105	26	promote	promote	VB
cord-259748-x7dq1sy4	105	27	transcription	transcription	NN
cord-259748-x7dq1sy4	105	28	of	of	IN
cord-259748-x7dq1sy4	105	29	type	type	NN
cord-259748-x7dq1sy4	105	30	-	-	:
cord-259748-x7dq1sy4	105	31	I	-PRON-	PRP
cord-259748-x7dq1sy4	105	32	IFN	IFN	NNP
cord-259748-x7dq1sy4	105	33	.	.	.
cord-259748-x7dq1sy4	106	1	(	(	-LRB-
cord-259748-x7dq1sy4	106	2	D	D	NNP
cord-259748-x7dq1sy4	106	3	)	)	-RRB-
cord-259748-x7dq1sy4	106	4	Autophagy	autophagy	JJ
cord-259748-x7dq1sy4	106	5	initiation	initiation	NN
cord-259748-x7dq1sy4	106	6	and	and	CC
cord-259748-x7dq1sy4	106	7	degradation	degradation	NN
cord-259748-x7dq1sy4	106	8	.	.	.
cord-259748-x7dq1sy4	107	1	STING	sting	NN
cord-259748-x7dq1sy4	107	2	activation	activation	NN
cord-259748-x7dq1sy4	107	3	on	on	IN
cord-259748-x7dq1sy4	107	4	ER	ER	NNP
cord-259748-x7dq1sy4	107	5	triggers	trigger	VBZ
cord-259748-x7dq1sy4	107	6	ER	ER	NNP
cord-259748-x7dq1sy4	107	7	stress	stress	NN
cord-259748-x7dq1sy4	107	8	and	and	CC
cord-259748-x7dq1sy4	107	9	mechanistic	mechanistic	JJ
cord-259748-x7dq1sy4	107	10	target	target	NN
cord-259748-x7dq1sy4	107	11	of	of	IN
cord-259748-x7dq1sy4	107	12	rapamycin	rapamycin	NN
cord-259748-x7dq1sy4	107	13	complex1	complex1	NN
cord-259748-x7dq1sy4	107	14	(	(	-LRB-
cord-259748-x7dq1sy4	107	15	mTORC1	mTORC1	NNP
cord-259748-x7dq1sy4	107	16	)	)	-RRB-
cord-259748-x7dq1sy4	107	17	dysfunction	dysfunction	NN
cord-259748-x7dq1sy4	107	18	.	.	.
cord-259748-x7dq1sy4	108	1	ER	ER	NNP
cord-259748-x7dq1sy4	108	2	stress	stress	NN
cord-259748-x7dq1sy4	108	3	and	and	CC
cord-259748-x7dq1sy4	108	4	mTORC1	mTORC1	NNP
cord-259748-x7dq1sy4	108	5	dysfunction	dysfunction	NN
cord-259748-x7dq1sy4	108	6	can	can	MD
cord-259748-x7dq1sy4	108	7	stimulate	stimulate	VB
cord-259748-x7dq1sy4	108	8	the	the	DT
cord-259748-x7dq1sy4	108	9	Unc-51	Unc-51	NNP
cord-259748-x7dq1sy4	108	10	like	like	IN
cord-259748-x7dq1sy4	108	11	autophagy	autophagy	NN
cord-259748-x7dq1sy4	108	12	activating	activate	VBG
cord-259748-x7dq1sy4	108	13	kinase	kinase	NN
cord-259748-x7dq1sy4	108	14	(	(	-LRB-
cord-259748-x7dq1sy4	108	15	ULK1	ULK1	NNP
cord-259748-x7dq1sy4	108	16	)	)	-RRB-
cord-259748-x7dq1sy4	108	17	complex	complex	NN
cord-259748-x7dq1sy4	108	18	and	and	CC
cord-259748-x7dq1sy4	108	19	beclin1-phosphatidylinositol	beclin1-phosphatidylinositol	RB
cord-259748-x7dq1sy4	108	20	3-kinase	3-kinase	CD
cord-259748-x7dq1sy4	108	21	catalytic	catalytic	JJ
cord-259748-x7dq1sy4	108	22	subunit	subunit	NN
cord-259748-x7dq1sy4	108	23	type	type	NN
cord-259748-x7dq1sy4	108	24	3	3	CD
cord-259748-x7dq1sy4	109	1	(	(	-LRB-
cord-259748-x7dq1sy4	109	2	PI3KC3	pi3kc3	NN
cord-259748-x7dq1sy4	109	3	)	)	-RRB-
cord-259748-x7dq1sy4	109	4	complex	complex	NN
cord-259748-x7dq1sy4	109	5	.	.	.
cord-259748-x7dq1sy4	110	1	Autophagy	Autophagy	NNP
cord-259748-x7dq1sy4	110	2	-	-	HYPH
cord-259748-x7dq1sy4	110	3	related	relate	VBN
cord-259748-x7dq1sy4	110	4	protein	protein	NN
cord-259748-x7dq1sy4	110	5	9	9	CD
cord-259748-x7dq1sy4	110	6	(	(	-LRB-
cord-259748-x7dq1sy4	110	7	ATG9	ATG9	NNP
cord-259748-x7dq1sy4	110	8	)	)	-RRB-
cord-259748-x7dq1sy4	110	9	and	and	CC
cord-259748-x7dq1sy4	110	10	light	light	JJ
cord-259748-x7dq1sy4	110	11	chain	chain	NN
cord-259748-x7dq1sy4	110	12	3	3	CD
cord-259748-x7dq1sy4	111	1	(	(	-LRB-
cord-259748-x7dq1sy4	111	2	LC3	LC3	NNP
cord-259748-x7dq1sy4	111	3	)	)	-RRB-
cord-259748-x7dq1sy4	111	4	are	be	VBP
cord-259748-x7dq1sy4	111	5	associated	associate	VBN
cord-259748-x7dq1sy4	111	6	with	with	IN
cord-259748-x7dq1sy4	111	7	genesis	genesis	NN
cord-259748-x7dq1sy4	111	8	and	and	CC
cord-259748-x7dq1sy4	111	9	elongation	elongation	NN
cord-259748-x7dq1sy4	111	10	of	of	IN
cord-259748-x7dq1sy4	111	11	the	the	DT
cord-259748-x7dq1sy4	111	12	autophagosome	autophagosome	NNP
cord-259748-x7dq1sy4	111	13	.	.	.
cord-259748-x7dq1sy4	112	1	After	after	IN
cord-259748-x7dq1sy4	112	2	autophagy	autophagy	NN
cord-259748-x7dq1sy4	112	3	initiation	initiation	NN
cord-259748-x7dq1sy4	112	4	,	,	,
cord-259748-x7dq1sy4	112	5	cGAS	cgas	NN
cord-259748-x7dq1sy4	112	6	-	-	HYPH
cord-259748-x7dq1sy4	112	7	STING	sting	NN
cord-259748-x7dq1sy4	112	8	is	be	VBZ
cord-259748-x7dq1sy4	112	9	ubiquitinated	ubiquitinate	VBN
cord-259748-x7dq1sy4	112	10	and	and	CC
cord-259748-x7dq1sy4	112	11	binds	bind	VBZ
cord-259748-x7dq1sy4	112	12	with	with	IN
cord-259748-x7dq1sy4	112	13	p62	p62	NN
cord-259748-x7dq1sy4	112	14	.	.	.
cord-259748-x7dq1sy4	113	1	Then	then	RB
cord-259748-x7dq1sy4	113	2	,	,	,
cord-259748-x7dq1sy4	113	3	they	-PRON-	PRP
cord-259748-x7dq1sy4	113	4	are	be	VBP
cord-259748-x7dq1sy4	113	5	packaged	package	VBN
cord-259748-x7dq1sy4	113	6	into	into	IN
cord-259748-x7dq1sy4	113	7	autophagosomes	autophagosome	NNS
cord-259748-x7dq1sy4	113	8	and	and	CC
cord-259748-x7dq1sy4	113	9	terminally	terminally	RB
cord-259748-x7dq1sy4	113	10	sorted	sort	VBN
cord-259748-x7dq1sy4	113	11	to	to	IN
cord-259748-x7dq1sy4	113	12	lysosomes	lysosome	NNS
cord-259748-x7dq1sy4	113	13	(	(	-LRB-
cord-259748-x7dq1sy4	113	14	Bold	bold	JJ
cord-259748-x7dq1sy4	113	15	arrows	arrow	NNS
cord-259748-x7dq1sy4	113	16	represent	represent	VBP
cord-259748-x7dq1sy4	113	17	main	main	JJ
cord-259748-x7dq1sy4	113	18	signaling	signal	VBG
cord-259748-x7dq1sy4	113	19	pathways	pathway	NNS
cord-259748-x7dq1sy4	113	20	,	,	,
cord-259748-x7dq1sy4	113	21	thinner	thin	JJR
cord-259748-x7dq1sy4	113	22	arrows	arrow	NNS
cord-259748-x7dq1sy4	113	23	represent	represent	VBP
cord-259748-x7dq1sy4	113	24	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	113	25	signaling	signal	VBG
cord-259748-x7dq1sy4	113	26	pathways	pathway	NNS
cord-259748-x7dq1sy4	113	27	,	,	,
cord-259748-x7dq1sy4	113	28	and	and	CC
cord-259748-x7dq1sy4	113	29	dashed	dash	VBD
cord-259748-x7dq1sy4	113	30	arrows	arrow	NNS
cord-259748-x7dq1sy4	113	31	represent	represent	VBP
cord-259748-x7dq1sy4	113	32	bypass	bypass	JJ
cord-259748-x7dq1sy4	113	33	or	or	CC
cord-259748-x7dq1sy4	113	34	suspicious	suspicious	JJ
cord-259748-x7dq1sy4	113	35	pathways	pathway	NNS
cord-259748-x7dq1sy4	113	36	)	)	-RRB-
cord-259748-x7dq1sy4	113	37	.	.	.
cord-259748-x7dq1sy4	114	1	ssDNA	ssdna	UH
cord-259748-x7dq1sy4	114	2	,	,	,
cord-259748-x7dq1sy4	114	3	and	and	CC
cord-259748-x7dq1sy4	114	4	start	start	VB
cord-259748-x7dq1sy4	114	5	DNA	dna	NN
cord-259748-x7dq1sy4	114	6	-	-	HYPH
cord-259748-x7dq1sy4	114	7	repair	repair	NN
cord-259748-x7dq1sy4	114	8	responses	response	NNS
cord-259748-x7dq1sy4	114	9	at	at	IN
cord-259748-x7dq1sy4	114	10	stalled	stall	VBN
cord-259748-x7dq1sy4	114	11	replication	replication	NN
cord-259748-x7dq1sy4	114	12	forks	fork	NNS
cord-259748-x7dq1sy4	114	13	(	(	-LRB-
cord-259748-x7dq1sy4	114	14	48	48	CD
cord-259748-x7dq1sy4	114	15	)	)	-RRB-
cord-259748-x7dq1sy4	114	16	.	.	.
cord-259748-x7dq1sy4	115	1	Depletion	depletion	NN
cord-259748-x7dq1sy4	115	2	of	of	IN
cord-259748-x7dq1sy4	115	3	SAMHD1	SAMHD1	NNS
cord-259748-x7dq1sy4	115	4	leads	lead	VBZ
cord-259748-x7dq1sy4	115	5	to	to	IN
cord-259748-x7dq1sy4	115	6	the	the	DT
cord-259748-x7dq1sy4	115	7	cleaving	cleaving	NN
cord-259748-x7dq1sy4	115	8	of	of	IN
cord-259748-x7dq1sy4	115	9	nascent	nascent	JJ
cord-259748-x7dq1sy4	115	10	ssDNA	ssdna	NN
cord-259748-x7dq1sy4	115	11	by	by	IN
cord-259748-x7dq1sy4	115	12	the	the	DT
cord-259748-x7dq1sy4	115	13	activity	activity	NN
cord-259748-x7dq1sy4	115	14	of	of	IN
cord-259748-x7dq1sy4	115	15	MRE11	MRE11	NNP
cord-259748-x7dq1sy4	115	16	endonuclease	endonuclease	NN
cord-259748-x7dq1sy4	115	17	and	and	CC
cord-259748-x7dq1sy4	115	18	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	115	19	translocation	translocation	NN
cord-259748-x7dq1sy4	115	20	of	of	IN
cord-259748-x7dq1sy4	115	21	gDNA	gdna	NN
cord-259748-x7dq1sy4	115	22	(	(	-LRB-
cord-259748-x7dq1sy4	115	23	48	48	CD
cord-259748-x7dq1sy4	115	24	)	)	-RRB-
cord-259748-x7dq1sy4	115	25	.	.	.
cord-259748-x7dq1sy4	116	1	Deficiency	deficiency	NN
cord-259748-x7dq1sy4	116	2	of	of	IN
cord-259748-x7dq1sy4	116	3	any	any	DT
cord-259748-x7dq1sy4	116	4	of	of	IN
cord-259748-x7dq1sy4	116	5	these	these	DT
cord-259748-x7dq1sy4	116	6	nucleases	nuclease	NNS
cord-259748-x7dq1sy4	116	7	can	can	MD
cord-259748-x7dq1sy4	116	8	lead	lead	VB
cord-259748-x7dq1sy4	116	9	to	to	IN
cord-259748-x7dq1sy4	116	10	accumulation	accumulation	NN
cord-259748-x7dq1sy4	116	11	of	of	IN
cord-259748-x7dq1sy4	116	12	self	self	NN
cord-259748-x7dq1sy4	116	13	-	-	HYPH
cord-259748-x7dq1sy4	116	14	DNA	dna	NN
cord-259748-x7dq1sy4	116	15	in	in	IN
cord-259748-x7dq1sy4	116	16	the	the	DT
cord-259748-x7dq1sy4	116	17	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	116	18	,	,	,
cord-259748-x7dq1sy4	116	19	thereby	thereby	RB
cord-259748-x7dq1sy4	116	20	activating	activate	VBG
cord-259748-x7dq1sy4	116	21	the	the	DT
cord-259748-x7dq1sy4	116	22	cGAS	cgas	JJ
cord-259748-x7dq1sy4	116	23	-	-	HYPH
cord-259748-x7dq1sy4	116	24	STING	sting	NN
cord-259748-x7dq1sy4	116	25	pathway	pathway	NN
cord-259748-x7dq1sy4	116	26	against	against	IN
cord-259748-x7dq1sy4	116	27	DNA	dna	NN
cord-259748-x7dq1sy4	116	28	molecules	molecule	NNS
cord-259748-x7dq1sy4	116	29	(	(	-LRB-
cord-259748-x7dq1sy4	116	30	30	30	CD
cord-259748-x7dq1sy4	116	31	)	)	-RRB-
cord-259748-x7dq1sy4	117	1	(	(	-LRB-
cord-259748-x7dq1sy4	117	2	Figure	figure	NN
cord-259748-x7dq1sy4	117	3	2A	2a	CD
cord-259748-x7dq1sy4	117	4	)	)	-RRB-
cord-259748-x7dq1sy4	117	5	.	.	.
cord-259748-x7dq1sy4	118	1	The	the	DT
cord-259748-x7dq1sy4	118	2	production	production	NN
cord-259748-x7dq1sy4	118	3	of	of	IN
cord-259748-x7dq1sy4	118	4	asymmetrically	asymmetrically	RB
cord-259748-x7dq1sy4	118	5	linked	link	VBN
cord-259748-x7dq1sy4	118	6	2	2	CD
cord-259748-x7dq1sy4	118	7	,	,	,
cord-259748-x7dq1sy4	118	8	3	3	CD
cord-259748-x7dq1sy4	118	9	-cGAMP	-cgamp	ADD
cord-259748-x7dq1sy4	118	10	catalyzed	catalyze	VBN
cord-259748-x7dq1sy4	118	11	by	by	IN
cord-259748-x7dq1sy4	118	12	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	118	13	has	have	VBZ
cord-259748-x7dq1sy4	118	14	the	the	DT
cord-259748-x7dq1sy4	118	15	highest	high	JJS
cord-259748-x7dq1sy4	118	16	affinity	affinity	NN
cord-259748-x7dq1sy4	118	17	for	for	IN
cord-259748-x7dq1sy4	118	18	STING	sting	NN
cord-259748-x7dq1sy4	118	19	to	to	TO
cord-259748-x7dq1sy4	118	20	promotes	promote	VBZ
cord-259748-x7dq1sy4	118	21	STING	sting	NN
cord-259748-x7dq1sy4	118	22	dimerization	dimerization	NN
cord-259748-x7dq1sy4	118	23	(	(	-LRB-
cord-259748-x7dq1sy4	118	24	49	49	CD
cord-259748-x7dq1sy4	118	25	,	,	,
cord-259748-x7dq1sy4	118	26	50	50	CD
cord-259748-x7dq1sy4	118	27	)	)	-RRB-
cord-259748-x7dq1sy4	118	28	.	.	.
cord-259748-x7dq1sy4	119	1	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	119	2	as	as	IN
cord-259748-x7dq1sy4	119	3	a	a	DT
cord-259748-x7dq1sy4	119	4	second	second	JJ
cord-259748-x7dq1sy4	119	5	messenger	messenger	NN
cord-259748-x7dq1sy4	119	6	can	can	MD
cord-259748-x7dq1sy4	119	7	be	be	VB
cord-259748-x7dq1sy4	119	8	also	also	RB
cord-259748-x7dq1sy4	119	9	transferred	transfer	VBN
cord-259748-x7dq1sy4	119	10	among	among	IN
cord-259748-x7dq1sy4	119	11	cells	cell	NNS
cord-259748-x7dq1sy4	119	12	in	in	IN
cord-259748-x7dq1sy4	119	13	several	several	JJ
cord-259748-x7dq1sy4	119	14	ways	way	NNS
cord-259748-x7dq1sy4	119	15	to	to	TO
cord-259748-x7dq1sy4	119	16	pass	pass	VB
cord-259748-x7dq1sy4	119	17	danger	danger	NN
cord-259748-x7dq1sy4	119	18	signaling	signaling	NN
cord-259748-x7dq1sy4	119	19	of	of	IN
cord-259748-x7dq1sy4	119	20	Frontiers	Frontiers	NNPS
cord-259748-x7dq1sy4	119	21	in	in	IN
cord-259748-x7dq1sy4	119	22	Immunology	Immunology	NNP
cord-259748-x7dq1sy4	119	23	|	|	NNP
cord-259748-x7dq1sy4	119	24	www.frontiersin.org	www.frontiersin.org	NN
cord-259748-x7dq1sy4	119	25	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	119	26	DNA	dna	NN
cord-259748-x7dq1sy4	119	27	.	.	.
cord-259748-x7dq1sy4	120	1	Intercellular	intercellular	JJ
cord-259748-x7dq1sy4	120	2	gap	gap	NN
cord-259748-x7dq1sy4	120	3	junction	junction	NN
cord-259748-x7dq1sy4	120	4	consists	consist	VBZ
cord-259748-x7dq1sy4	120	5	of	of	IN
cord-259748-x7dq1sy4	120	6	two	two	CD
cord-259748-x7dq1sy4	120	7	docking	docking	NN
cord-259748-x7dq1sy4	120	8	hexamer	hexamer	NN
cord-259748-x7dq1sy4	120	9	channels	channel	NNS
cord-259748-x7dq1sy4	120	10	formed	form	VBN
cord-259748-x7dq1sy4	120	11	by	by	IN
cord-259748-x7dq1sy4	120	12	different	different	JJ
cord-259748-x7dq1sy4	120	13	connexins	connexin	NNS
cord-259748-x7dq1sy4	120	14	,	,	,
cord-259748-x7dq1sy4	120	15	which	which	WDT
cord-259748-x7dq1sy4	120	16	allows	allow	VBZ
cord-259748-x7dq1sy4	120	17	many	many	JJ
cord-259748-x7dq1sy4	120	18	small	small	JJ
cord-259748-x7dq1sy4	120	19	molecules	molecule	NNS
cord-259748-x7dq1sy4	120	20	,	,	,
cord-259748-x7dq1sy4	120	21	including	include	VBG
cord-259748-x7dq1sy4	120	22	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	120	23	,	,	,
cord-259748-x7dq1sy4	120	24	to	to	TO
cord-259748-x7dq1sy4	120	25	pass	pass	VB
cord-259748-x7dq1sy4	120	26	bi	bi	NNP
cord-259748-x7dq1sy4	120	27	-	-	NN
cord-259748-x7dq1sy4	120	28	directionally	directionally	RB
cord-259748-x7dq1sy4	120	29	through	through	IN
cord-259748-x7dq1sy4	120	30	cells	cell	NNS
cord-259748-x7dq1sy4	120	31	.	.	.
cord-259748-x7dq1sy4	121	1	And	and	CC
cord-259748-x7dq1sy4	121	2	intercellular	intercellular	JJ
cord-259748-x7dq1sy4	121	3	transfer	transfer	NN
cord-259748-x7dq1sy4	121	4	of	of	IN
cord-259748-x7dq1sy4	121	5	cGAMP	cgamp	NN
cord-259748-x7dq1sy4	121	6	through	through	IN
cord-259748-x7dq1sy4	121	7	gap	gap	NN
cord-259748-x7dq1sy4	121	8	junction	junction	NN
cord-259748-x7dq1sy4	121	9	is	be	VBZ
cord-259748-x7dq1sy4	121	10	largely	largely	RB
cord-259748-x7dq1sy4	121	11	dependent	dependent	JJ
cord-259748-x7dq1sy4	121	12	on	on	IN
cord-259748-x7dq1sy4	121	13	connexin	connexin	NNP
cord-259748-x7dq1sy4	121	14	43	43	CD
cord-259748-x7dq1sy4	121	15	(	(	-LRB-
cord-259748-x7dq1sy4	121	16	51	51	CD
cord-259748-x7dq1sy4	121	17	)	)	-RRB-
cord-259748-x7dq1sy4	121	18	(	(	-LRB-
cord-259748-x7dq1sy4	121	19	52	52	CD
cord-259748-x7dq1sy4	121	20	)	)	-RRB-
cord-259748-x7dq1sy4	121	21	(	(	-LRB-
cord-259748-x7dq1sy4	121	22	53	53	CD
cord-259748-x7dq1sy4	121	23	)	)	-RRB-
cord-259748-x7dq1sy4	121	24	.	.	.
cord-259748-x7dq1sy4	122	1	Additionally	additionally	RB
cord-259748-x7dq1sy4	122	2	,	,	,
cord-259748-x7dq1sy4	122	3	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	122	4	can	can	MD
cord-259748-x7dq1sy4	122	5	be	be	VB
cord-259748-x7dq1sy4	122	6	packaged	package	VBN
cord-259748-x7dq1sy4	122	7	into	into	IN
cord-259748-x7dq1sy4	122	8	virons	viron	NNS
cord-259748-x7dq1sy4	122	9	and	and	CC
cord-259748-x7dq1sy4	122	10	pre	pre	JJ
cord-259748-x7dq1sy4	122	11	-	-	VB
cord-259748-x7dq1sy4	122	12	notify	notify	VB
cord-259748-x7dq1sy4	122	13	newly	newly	RB
cord-259748-x7dq1sy4	122	14	infected	infect	VBN
cord-259748-x7dq1sy4	122	15	cells	cell	NNS
cord-259748-x7dq1sy4	122	16	(	(	-LRB-
cord-259748-x7dq1sy4	122	17	54	54	CD
cord-259748-x7dq1sy4	122	18	,	,	,
cord-259748-x7dq1sy4	122	19	55	55	CD
cord-259748-x7dq1sy4	122	20	)	)	-RRB-
cord-259748-x7dq1sy4	122	21	.	.	.
cord-259748-x7dq1sy4	123	1	Cell	cell	NN
cord-259748-x7dq1sy4	123	2	fusion	fusion	NN
cord-259748-x7dq1sy4	123	3	is	be	VBZ
cord-259748-x7dq1sy4	123	4	a	a	DT
cord-259748-x7dq1sy4	123	5	distinct	distinct	JJ
cord-259748-x7dq1sy4	123	6	manner	manner	NN
cord-259748-x7dq1sy4	123	7	for	for	IN
cord-259748-x7dq1sy4	123	8	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	123	9	transmission	transmission	NN
cord-259748-x7dq1sy4	123	10	of	of	IN
cord-259748-x7dq1sy4	123	11	the	the	DT
cord-259748-x7dq1sy4	123	12	human	human	JJ
cord-259748-x7dq1sy4	123	13	immunodeficiency	immunodeficiency	NN
cord-259748-x7dq1sy4	123	14	virus	virus	NN
cord-259748-x7dq1sy4	123	15	(	(	-LRB-
cord-259748-x7dq1sy4	123	16	HIV	HIV	NNP
cord-259748-x7dq1sy4	123	17	)	)	-RRB-
cord-259748-x7dq1sy4	123	18	;	;	:
cord-259748-x7dq1sy4	123	19	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	123	20	also	also	RB
cord-259748-x7dq1sy4	123	21	enter	enter	VB
cord-259748-x7dq1sy4	123	22	membrane	membrane	NN
cord-259748-x7dq1sy4	123	23	-	-	HYPH
cord-259748-x7dq1sy4	123	24	fused	fuse	VBN
cord-259748-x7dq1sy4	123	25	bystander	bystander	NN
cord-259748-x7dq1sy4	123	26	cells	cell	NNS
cord-259748-x7dq1sy4	123	27	in	in	IN
cord-259748-x7dq1sy4	123	28	this	this	DT
cord-259748-x7dq1sy4	123	29	way	way	NN
cord-259748-x7dq1sy4	123	30	(	(	-LRB-
cord-259748-x7dq1sy4	123	31	56	56	CD
cord-259748-x7dq1sy4	123	32	)	)	-RRB-
cord-259748-x7dq1sy4	123	33	.	.	.
cord-259748-x7dq1sy4	124	1	Extracellular	Extracellular	NNP
cord-259748-x7dq1sy4	124	2	vesicles	vesicle	NNS
cord-259748-x7dq1sy4	124	3	such	such	JJ
cord-259748-x7dq1sy4	124	4	as	as	IN
cord-259748-x7dq1sy4	124	5	exosomes	exosome	NNS
cord-259748-x7dq1sy4	124	6	can	can	MD
cord-259748-x7dq1sy4	124	7	contain	contain	VB
cord-259748-x7dq1sy4	124	8	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	124	9	along	along	IN
cord-259748-x7dq1sy4	124	10	with	with	IN
cord-259748-x7dq1sy4	124	11	viral	viral	JJ
cord-259748-x7dq1sy4	124	12	DNA	dna	NN
cord-259748-x7dq1sy4	124	13	,	,	,
cord-259748-x7dq1sy4	124	14	host	host	NN
cord-259748-x7dq1sy4	124	15	gDNA	gdna	NN
cord-259748-x7dq1sy4	124	16	or	or	CC
cord-259748-x7dq1sy4	124	17	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	124	18	,	,	,
cord-259748-x7dq1sy4	124	19	and	and	CC
cord-259748-x7dq1sy4	124	20	mediate	mediate	VB
cord-259748-x7dq1sy4	124	21	cells	cell	NNS
cord-259748-x7dq1sy4	124	22	communication	communication	NN
cord-259748-x7dq1sy4	124	23	(	(	-LRB-
cord-259748-x7dq1sy4	124	24	57	57	CD
cord-259748-x7dq1sy4	124	25	,	,	,
cord-259748-x7dq1sy4	124	26	58	58	CD
cord-259748-x7dq1sy4	124	27	)	)	-RRB-
cord-259748-x7dq1sy4	124	28	.	.	.
cord-259748-x7dq1sy4	125	1	There	there	EX
cord-259748-x7dq1sy4	125	2	were	be	VBD
cord-259748-x7dq1sy4	125	3	no	no	DT
cord-259748-x7dq1sy4	125	4	evidences	evidence	NNS
cord-259748-x7dq1sy4	125	5	that	that	IN
cord-259748-x7dq1sy4	125	6	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	125	7	could	could	MD
cord-259748-x7dq1sy4	125	8	be	be	VB
cord-259748-x7dq1sy4	125	9	pumped	pump	VBN
cord-259748-x7dq1sy4	125	10	out	out	RP
cord-259748-x7dq1sy4	125	11	to	to	IN
cord-259748-x7dq1sy4	125	12	extracellular	extracellular	JJ
cord-259748-x7dq1sy4	125	13	space	space	NN
cord-259748-x7dq1sy4	125	14	by	by	IN
cord-259748-x7dq1sy4	125	15	a	a	DT
cord-259748-x7dq1sy4	125	16	channel	channel	NN
cord-259748-x7dq1sy4	125	17	/	/	SYM
cord-259748-x7dq1sy4	125	18	transporter	transporter	NN
cord-259748-x7dq1sy4	125	19	.	.	.
cord-259748-x7dq1sy4	126	1	However	however	RB
cord-259748-x7dq1sy4	126	2	,	,	,
cord-259748-x7dq1sy4	126	3	it	-PRON-	PRP
cord-259748-x7dq1sy4	126	4	was	be	VBD
cord-259748-x7dq1sy4	126	5	found	find	VBN
cord-259748-x7dq1sy4	126	6	that	that	IN
cord-259748-x7dq1sy4	126	7	SLC19A1	slc19a1	NN
cord-259748-x7dq1sy4	126	8	can	can	MD
cord-259748-x7dq1sy4	126	9	transmit	transmit	VB
cord-259748-x7dq1sy4	126	10	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	126	11	dinucleotides	dinucleotide	NNS
cord-259748-x7dq1sy4	126	12	(	(	-LRB-
cord-259748-x7dq1sy4	126	13	CDNs	CDNs	NNP
cord-259748-x7dq1sy4	126	14	)	)	-RRB-
cord-259748-x7dq1sy4	126	15	into	into	IN
cord-259748-x7dq1sy4	126	16	cell	cell	NN
cord-259748-x7dq1sy4	126	17	plasma	plasma	NN
cord-259748-x7dq1sy4	126	18	(	(	-LRB-
cord-259748-x7dq1sy4	126	19	59	59	CD
cord-259748-x7dq1sy4	126	20	,	,	,
cord-259748-x7dq1sy4	126	21	60	60	CD
cord-259748-x7dq1sy4	126	22	)	)	-RRB-
cord-259748-x7dq1sy4	126	23	.	.	.
cord-259748-x7dq1sy4	127	1	Notably	notably	RB
cord-259748-x7dq1sy4	127	2	,	,	,
cord-259748-x7dq1sy4	127	3	ectonucleotide	ectonucleotide	NNP
cord-259748-x7dq1sy4	127	4	pyrophosphatase	pyrophosphatase	NNP
cord-259748-x7dq1sy4	127	5	/	/	SYM
cord-259748-x7dq1sy4	127	6	phosphodiesterase	phosphodiesterase	NNP
cord-259748-x7dq1sy4	127	7	family	family	NN
cord-259748-x7dq1sy4	127	8	member	member	NN
cord-259748-x7dq1sy4	127	9	1	1	CD
cord-259748-x7dq1sy4	127	10	(	(	-LRB-
cord-259748-x7dq1sy4	127	11	ENPP-1	ENPP-1	NNP
cord-259748-x7dq1sy4	127	12	)	)	-RRB-
cord-259748-x7dq1sy4	127	13	can	can	MD
cord-259748-x7dq1sy4	127	14	degrade	degrade	VB
cord-259748-x7dq1sy4	127	15	extracellular	extracellular	JJ
cord-259748-x7dq1sy4	127	16	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	127	17	(	(	-LRB-
cord-259748-x7dq1sy4	127	18	61	61	CD
cord-259748-x7dq1sy4	127	19	)	)	-RRB-
cord-259748-x7dq1sy4	127	20	(	(	-LRB-
cord-259748-x7dq1sy4	127	21	Figure	figure	NN
cord-259748-x7dq1sy4	127	22	2B	2b	CD
cord-259748-x7dq1sy4	127	23	)	)	-RRB-
cord-259748-x7dq1sy4	127	24	.	.	.
cord-259748-x7dq1sy4	128	1	Besides	besides	IN
cord-259748-x7dq1sy4	128	2	triggering	trigger	VBG
cord-259748-x7dq1sy4	128	3	STING	sting	NN
cord-259748-x7dq1sy4	128	4	,	,	,
cord-259748-x7dq1sy4	128	5	these	these	DT
cord-259748-x7dq1sy4	128	6	exogenous	exogenous	JJ
cord-259748-x7dq1sy4	128	7	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	128	8	can	can	MD
cord-259748-x7dq1sy4	128	9	directly	directly	RB
cord-259748-x7dq1sy4	128	10	bind	bind	VB
cord-259748-x7dq1sy4	128	11	to	to	IN
cord-259748-x7dq1sy4	128	12	cGAS	cgas	VB
cord-259748-x7dq1sy4	128	13	and	and	CC
cord-259748-x7dq1sy4	128	14	prompt	prompt	VB
cord-259748-x7dq1sy4	128	15	its	-PRON-	PRP$
cord-259748-x7dq1sy4	128	16	activation	activation	NN
cord-259748-x7dq1sy4	128	17	as	as	RB
cord-259748-x7dq1sy4	128	18	well	well	RB
cord-259748-x7dq1sy4	128	19	(	(	-LRB-
cord-259748-x7dq1sy4	128	20	62	62	CD
cord-259748-x7dq1sy4	128	21	)	)	-RRB-
cord-259748-x7dq1sy4	128	22	.	.	.
cord-259748-x7dq1sy4	129	1	After	after	IN
cord-259748-x7dq1sy4	129	2	binding	bind	VBG
cord-259748-x7dq1sy4	129	3	to	to	IN
cord-259748-x7dq1sy4	129	4	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	129	5	,	,	,
cord-259748-x7dq1sy4	129	6	the	the	DT
cord-259748-x7dq1sy4	129	7	"	"	``
cord-259748-x7dq1sy4	129	8	lid	lid	NN
cord-259748-x7dq1sy4	129	9	"	"	''
cord-259748-x7dq1sy4	129	10	region	region	NN
cord-259748-x7dq1sy4	129	11	of	of	IN
cord-259748-x7dq1sy4	129	12	the	the	DT
cord-259748-x7dq1sy4	129	13	STING	sting	NN
cord-259748-x7dq1sy4	129	14	dimer	dimer	NN
cord-259748-x7dq1sy4	129	15	undergoes	undergo	VBZ
cord-259748-x7dq1sy4	129	16	a	a	DT
cord-259748-x7dq1sy4	129	17	conformational	conformational	JJ
cord-259748-x7dq1sy4	129	18	change	change	NN
cord-259748-x7dq1sy4	129	19	that	that	WDT
cord-259748-x7dq1sy4	129	20	converts	convert	VBZ
cord-259748-x7dq1sy4	129	21	STING	sting	NN
cord-259748-x7dq1sy4	129	22	from	from	IN
cord-259748-x7dq1sy4	129	23	an	an	DT
cord-259748-x7dq1sy4	129	24	inactive	inactive	JJ
cord-259748-x7dq1sy4	129	25	"	"	``
cord-259748-x7dq1sy4	129	26	open	open	JJ
cord-259748-x7dq1sy4	129	27	"	"	''
cord-259748-x7dq1sy4	129	28	formation	formation	NN
cord-259748-x7dq1sy4	129	29	to	to	IN
cord-259748-x7dq1sy4	129	30	an	an	DT
cord-259748-x7dq1sy4	129	31	active	active	JJ
cord-259748-x7dq1sy4	129	32	"	"	``
cord-259748-x7dq1sy4	129	33	closed	closed	JJ
cord-259748-x7dq1sy4	129	34	"	"	''
cord-259748-x7dq1sy4	129	35	formation	formation	NN
cord-259748-x7dq1sy4	129	36	.	.	.
cord-259748-x7dq1sy4	130	1	Following	follow	VBG
cord-259748-x7dq1sy4	130	2	that	that	IN
cord-259748-x7dq1sy4	130	3	,	,	,
cord-259748-x7dq1sy4	130	4	the	the	DT
cord-259748-x7dq1sy4	130	5	STING	sting	NN
cord-259748-x7dq1sy4	130	6	dimer	dimer	NN
cord-259748-x7dq1sy4	130	7	translocates	translocate	NNS
cord-259748-x7dq1sy4	130	8	from	from	IN
cord-259748-x7dq1sy4	130	9	the	the	DT
cord-259748-x7dq1sy4	130	10	ER	ER	NNP
cord-259748-x7dq1sy4	130	11	to	to	IN
cord-259748-x7dq1sy4	130	12	perinuclear	perinuclear	NNP
cord-259748-x7dq1sy4	130	13	ER	ER	NNP
cord-259748-x7dq1sy4	130	14	-	-	HYPH
cord-259748-x7dq1sy4	130	15	Golgi	Golgi	NNP
cord-259748-x7dq1sy4	130	16	intermediate	intermediate	JJ
cord-259748-x7dq1sy4	130	17	compartment	compartment	NN
cord-259748-x7dq1sy4	130	18	(	(	-LRB-
cord-259748-x7dq1sy4	130	19	ERGIC	ERGIC	NNP
cord-259748-x7dq1sy4	130	20	)	)	-RRB-
cord-259748-x7dq1sy4	130	21	vesicles	vesicle	NNS
cord-259748-x7dq1sy4	130	22	,	,	,
cord-259748-x7dq1sy4	130	23	finally	finally	RB
cord-259748-x7dq1sy4	130	24	arriving	arrive	VBG
cord-259748-x7dq1sy4	130	25	at	at	IN
cord-259748-x7dq1sy4	130	26	the	the	DT
cord-259748-x7dq1sy4	130	27	Golgi	Golgi	NNP
cord-259748-x7dq1sy4	130	28	to	to	TO
cord-259748-x7dq1sy4	130	29	form	form	VB
cord-259748-x7dq1sy4	130	30	punctuate	punctuate	VB
cord-259748-x7dq1sy4	130	31	structures	structure	NNS
cord-259748-x7dq1sy4	130	32	with	with	IN
cord-259748-x7dq1sy4	130	33	downstream	downstream	JJ
cord-259748-x7dq1sy4	130	34	molecules	molecule	NNS
cord-259748-x7dq1sy4	130	35	(	(	-LRB-
cord-259748-x7dq1sy4	130	36	2	2	CD
cord-259748-x7dq1sy4	130	37	,	,	,
cord-259748-x7dq1sy4	130	38	63	63	CD
cord-259748-x7dq1sy4	130	39	)	)	-RRB-
cord-259748-x7dq1sy4	130	40	.	.	.
cord-259748-x7dq1sy4	131	1	ER	er	NN
cord-259748-x7dq1sy4	131	2	-	-	HYPH
cord-259748-x7dq1sy4	131	3	retention	retention	NN
cord-259748-x7dq1sy4	131	4	of	of	IN
cord-259748-x7dq1sy4	131	5	STING	sting	NN
cord-259748-x7dq1sy4	131	6	caused	cause	VBN
cord-259748-x7dq1sy4	131	7	by	by	IN
cord-259748-x7dq1sy4	131	8	mutations	mutation	NNS
cord-259748-x7dq1sy4	131	9	results	result	NNS
cord-259748-x7dq1sy4	131	10	in	in	IN
cord-259748-x7dq1sy4	131	11	reduced	reduce	VBN
cord-259748-x7dq1sy4	131	12	IFN	IFN	NNP
cord-259748-x7dq1sy4	131	13	signaling	signal	VBG
cord-259748-x7dq1sy4	131	14	(	(	-LRB-
cord-259748-x7dq1sy4	131	15	64	64	CD
cord-259748-x7dq1sy4	131	16	,	,	,
cord-259748-x7dq1sy4	131	17	65	65	CD
cord-259748-x7dq1sy4	131	18	)	)	-RRB-
cord-259748-x7dq1sy4	131	19	.	.	.
cord-259748-x7dq1sy4	132	1	The	the	DT
cord-259748-x7dq1sy4	132	2	translocon	translocon	NN
cord-259748-x7dq1sy4	132	3	-	-	HYPH
cord-259748-x7dq1sy4	132	4	associated	associate	VBN
cord-259748-x7dq1sy4	132	5	protein	protein	NN
cord-259748-x7dq1sy4	132	6	β	β	NNP
cord-259748-x7dq1sy4	132	7	(	(	-LRB-
cord-259748-x7dq1sy4	132	8	TRAPβ	TRAPβ	NNP
cord-259748-x7dq1sy4	132	9	)	)	-RRB-
cord-259748-x7dq1sy4	132	10	recruited	recruit	VBN
cord-259748-x7dq1sy4	132	11	by	by	IN
cord-259748-x7dq1sy4	132	12	inactive	inactive	JJ
cord-259748-x7dq1sy4	132	13	rhomboid	rhomboid	JJ
cord-259748-x7dq1sy4	132	14	protein	protein	NN
cord-259748-x7dq1sy4	132	15	2	2	CD
cord-259748-x7dq1sy4	133	1	(	(	-LRB-
cord-259748-x7dq1sy4	133	2	iRhom2	iRhom2	NNP
cord-259748-x7dq1sy4	133	3	)	)	-RRB-
cord-259748-x7dq1sy4	133	4	initially	initially	RB
cord-259748-x7dq1sy4	133	5	forms	form	VBZ
cord-259748-x7dq1sy4	133	6	the	the	DT
cord-259748-x7dq1sy4	133	7	TRAP	trap	NN
cord-259748-x7dq1sy4	133	8	translocon	translocon	NN
cord-259748-x7dq1sy4	133	9	complex	complex	NN
cord-259748-x7dq1sy4	133	10	that	that	WDT
cord-259748-x7dq1sy4	133	11	mediates	mediate	VBZ
cord-259748-x7dq1sy4	133	12	STING	sting	NN
cord-259748-x7dq1sy4	133	13	exit	exit	NN
cord-259748-x7dq1sy4	133	14	from	from	IN
cord-259748-x7dq1sy4	133	15	the	the	DT
cord-259748-x7dq1sy4	133	16	ER	ER	NNP
cord-259748-x7dq1sy4	133	17	(	(	-LRB-
cord-259748-x7dq1sy4	133	18	2	2	CD
cord-259748-x7dq1sy4	133	19	,	,	,
cord-259748-x7dq1sy4	133	20	66	66	CD
cord-259748-x7dq1sy4	133	21	)	)	-RRB-
cord-259748-x7dq1sy4	133	22	.	.	.
cord-259748-x7dq1sy4	134	1	They	-PRON-	PRP
cord-259748-x7dq1sy4	134	2	both	both	DT
cord-259748-x7dq1sy4	134	3	assist	assist	VBP
cord-259748-x7dq1sy4	134	4	cytoplasmic	cytoplasmic	JJ
cord-259748-x7dq1sy4	134	5	coat	coat	NN
cord-259748-x7dq1sy4	134	6	protein	protein	NN
cord-259748-x7dq1sy4	134	7	complex	complex	NN
cord-259748-x7dq1sy4	134	8	-	-	:
cord-259748-x7dq1sy4	134	9	II	II	NNP
cord-259748-x7dq1sy4	134	10	(	(	-LRB-
cord-259748-x7dq1sy4	134	11	COPII	COPII	NNP
cord-259748-x7dq1sy4	134	12	)	)	-RRB-
cord-259748-x7dq1sy4	134	13	to	to	TO
cord-259748-x7dq1sy4	134	14	drive	drive	VB
cord-259748-x7dq1sy4	134	15	ER	ER	NNP
cord-259748-x7dq1sy4	134	16	-	-	HYPH
cord-259748-x7dq1sy4	134	17	vesicle	vesicle	NN
cord-259748-x7dq1sy4	134	18	formation	formation	NN
cord-259748-x7dq1sy4	134	19	and	and	CC
cord-259748-x7dq1sy4	134	20	carry	carry	VB
cord-259748-x7dq1sy4	134	21	the	the	DT
cord-259748-x7dq1sy4	134	22	STING	sting	NN
cord-259748-x7dq1sy4	134	23	complex	complex	JJ
cord-259748-x7dq1sy4	134	24	to	to	IN
cord-259748-x7dq1sy4	134	25	the	the	DT
cord-259748-x7dq1sy4	134	26	Golgi	Golgi	NNP
cord-259748-x7dq1sy4	134	27	(	(	-LRB-
cord-259748-x7dq1sy4	134	28	67	67	CD
cord-259748-x7dq1sy4	134	29	,	,	,
cord-259748-x7dq1sy4	134	30	68	68	CD
cord-259748-x7dq1sy4	134	31	)	)	-RRB-
cord-259748-x7dq1sy4	134	32	.	.	.
cord-259748-x7dq1sy4	135	1	Trafficking	traffic	VBG
cord-259748-x7dq1sy4	135	2	STING	sting	NN
cord-259748-x7dq1sy4	135	3	can	can	MD
cord-259748-x7dq1sy4	135	4	bind	bind	VB
cord-259748-x7dq1sy4	135	5	directly	directly	RB
cord-259748-x7dq1sy4	135	6	to	to	TO
cord-259748-x7dq1sy4	135	7	and	and	CC
cord-259748-x7dq1sy4	135	8	be	be	VB
cord-259748-x7dq1sy4	135	9	phosphorylated	phosphorylate	VBN
cord-259748-x7dq1sy4	135	10	by	by	IN
cord-259748-x7dq1sy4	135	11	TANK	tank	NN
cord-259748-x7dq1sy4	135	12	binding	binding	NN
cord-259748-x7dq1sy4	135	13	kinase	kinase	NN
cord-259748-x7dq1sy4	135	14	1	1	CD
cord-259748-x7dq1sy4	136	1	(	(	-LRB-
cord-259748-x7dq1sy4	136	2	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	136	3	)	)	-RRB-
cord-259748-x7dq1sy4	136	4	dimer	dimer	NN
cord-259748-x7dq1sy4	136	5	or	or	CC
cord-259748-x7dq1sy4	136	6	IκB	iκb	NN
cord-259748-x7dq1sy4	136	7	kinase	kinase	NN
cord-259748-x7dq1sy4	136	8	(	(	-LRB-
cord-259748-x7dq1sy4	136	9	IKK	IKK	NNP
cord-259748-x7dq1sy4	136	10	)	)	-RRB-
cord-259748-x7dq1sy4	136	11	complex	complex	NNP
cord-259748-x7dq1sy4	136	12	(	(	-LRB-
cord-259748-x7dq1sy4	136	13	3	3	CD
cord-259748-x7dq1sy4	136	14	,	,	,
cord-259748-x7dq1sy4	136	15	69	69	CD
cord-259748-x7dq1sy4	136	16	,	,	,
cord-259748-x7dq1sy4	136	17	70	70	CD
cord-259748-x7dq1sy4	136	18	)	)	-RRB-
cord-259748-x7dq1sy4	136	19	.	.	.
cord-259748-x7dq1sy4	137	1	The	the	DT
cord-259748-x7dq1sy4	137	2	C	c	NN
cord-259748-x7dq1sy4	137	3	-	-	HYPH
cord-259748-x7dq1sy4	137	4	terminal	terminal	NN
cord-259748-x7dq1sy4	137	5	tail	tail	NN
cord-259748-x7dq1sy4	137	6	(	(	-LRB-
cord-259748-x7dq1sy4	137	7	CTT	CTT	NNP
cord-259748-x7dq1sy4	137	8	)	)	-RRB-
cord-259748-x7dq1sy4	137	9	of	of	IN
cord-259748-x7dq1sy4	137	10	STING	STING	NNP
cord-259748-x7dq1sy4	137	11	is	be	VBZ
cord-259748-x7dq1sy4	137	12	a	a	DT
cord-259748-x7dq1sy4	137	13	linear	linear	JJ
cord-259748-x7dq1sy4	137	14	unfolded	unfold	VBN
cord-259748-x7dq1sy4	137	15	segment	segment	NN
cord-259748-x7dq1sy4	137	16	,	,	,
cord-259748-x7dq1sy4	137	17	which	which	WDT
cord-259748-x7dq1sy4	137	18	determines	determine	VBZ
cord-259748-x7dq1sy4	137	19	the	the	DT
cord-259748-x7dq1sy4	137	20	optimization	optimization	NN
cord-259748-x7dq1sy4	137	21	of	of	IN
cord-259748-x7dq1sy4	137	22	combination	combination	NN
cord-259748-x7dq1sy4	137	23	specificity	specificity	NN
cord-259748-x7dq1sy4	137	24	.	.	.
cord-259748-x7dq1sy4	138	1	STING	STING	NNP
cord-259748-x7dq1sy4	138	2	CTT	CTT	NNP
cord-259748-x7dq1sy4	138	3	in	in	IN
cord-259748-x7dq1sy4	138	4	mammals	mammal	NNS
cord-259748-x7dq1sy4	138	5	tends	tend	VBZ
cord-259748-x7dq1sy4	138	6	to	to	TO
cord-259748-x7dq1sy4	138	7	bind	bind	VB
cord-259748-x7dq1sy4	138	8	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	138	9	,	,	,
cord-259748-x7dq1sy4	138	10	whereas	whereas	IN
cord-259748-x7dq1sy4	138	11	in	in	IN
cord-259748-x7dq1sy4	138	12	fish	fish	NN
cord-259748-x7dq1sy4	138	13	it	-PRON-	PRP
cord-259748-x7dq1sy4	138	14	tends	tend	VBZ
cord-259748-x7dq1sy4	138	15	to	to	TO
cord-259748-x7dq1sy4	138	16	activate	activate	VB
cord-259748-x7dq1sy4	138	17	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	138	18	factor	factor	NN
cord-259748-x7dq1sy4	138	19	-	-	:
cord-259748-x7dq1sy4	138	20	kappaB	kappaB	NNP
cord-259748-x7dq1sy4	138	21	(	(	-LRB-
cord-259748-x7dq1sy4	138	22	NF	nf	NN
cord-259748-x7dq1sy4	138	23	-	-	HYPH
cord-259748-x7dq1sy4	138	24	κB	κB	NNP
cord-259748-x7dq1sy4	138	25	)	)	-RRB-
cord-259748-x7dq1sy4	138	26	signal	signal	NN
cord-259748-x7dq1sy4	138	27	(	(	-LRB-
cord-259748-x7dq1sy4	138	28	71	71	CD
cord-259748-x7dq1sy4	138	29	)	)	-RRB-
cord-259748-x7dq1sy4	138	30	.	.	.
cord-259748-x7dq1sy4	139	1	The	the	DT
cord-259748-x7dq1sy4	139	2	STING	sting	NN
cord-259748-x7dq1sy4	139	3	phosphorylation	phosphorylation	NN
cord-259748-x7dq1sy4	139	4	site	site	NN
cord-259748-x7dq1sy4	139	5	Ser366	Ser366	:
cord-259748-x7dq1sy4	139	6	in	in	IN
cord-259748-x7dq1sy4	139	7	the	the	DT
cord-259748-x7dq1sy4	139	8	CTT	CTT	NNP
cord-259748-x7dq1sy4	139	9	can	can	MD
cord-259748-x7dq1sy4	139	10	not	not	RB
cord-259748-x7dq1sy4	139	11	reach	reach	VB
cord-259748-x7dq1sy4	139	12	the	the	DT
cord-259748-x7dq1sy4	139	13	kinase	kinase	NN
cord-259748-x7dq1sy4	139	14	-	-	HYPH
cord-259748-x7dq1sy4	139	15	domain	domain	NN
cord-259748-x7dq1sy4	139	16	active	active	JJ
cord-259748-x7dq1sy4	139	17	site	site	NN
cord-259748-x7dq1sy4	139	18	of	of	IN
cord-259748-x7dq1sy4	139	19	its	-PRON-	PRP$
cord-259748-x7dq1sy4	139	20	directly	directly	RB
cord-259748-x7dq1sy4	139	21	bound	bind	VBN
cord-259748-x7dq1sy4	139	22	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	139	23	,	,	,
cord-259748-x7dq1sy4	139	24	instead	instead	RB
cord-259748-x7dq1sy4	139	25	can	can	MD
cord-259748-x7dq1sy4	139	26	reach	reach	VB
cord-259748-x7dq1sy4	139	27	the	the	DT
cord-259748-x7dq1sy4	139	28	kinase	kinase	NN
cord-259748-x7dq1sy4	139	29	-	-	HYPH
cord-259748-x7dq1sy4	139	30	domain	domain	NN
cord-259748-x7dq1sy4	139	31	active	active	JJ
cord-259748-x7dq1sy4	139	32	site	site	NN
cord-259748-x7dq1sy4	139	33	of	of	IN
cord-259748-x7dq1sy4	139	34	the	the	DT
cord-259748-x7dq1sy4	139	35	next	next	JJ
cord-259748-x7dq1sy4	139	36	adjacent	adjacent	JJ
cord-259748-x7dq1sy4	139	37	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	139	38	binding	bind	VBG
cord-259748-x7dq1sy4	139	39	with	with	IN
cord-259748-x7dq1sy4	139	40	another	another	DT
cord-259748-x7dq1sy4	139	41	STING	sting	NN
cord-259748-x7dq1sy4	139	42	and	and	CC
cord-259748-x7dq1sy4	139	43	be	be	VB
cord-259748-x7dq1sy4	139	44	phosphorylated	phosphorylate	VBN
cord-259748-x7dq1sy4	139	45	,	,	,
cord-259748-x7dq1sy4	139	46	while	while	IN
cord-259748-x7dq1sy4	139	47	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	139	48	phosphorylate	phosphorylate	VBP
cord-259748-x7dq1sy4	139	49	each	each	DT
cord-259748-x7dq1sy4	139	50	other	other	JJ
cord-259748-x7dq1sy4	139	51	(	(	-LRB-
cord-259748-x7dq1sy4	139	52	72	72	CD
cord-259748-x7dq1sy4	139	53	,	,	,
cord-259748-x7dq1sy4	139	54	73	73	CD
cord-259748-x7dq1sy4	139	55	)	)	-RRB-
cord-259748-x7dq1sy4	139	56	.	.	.
cord-259748-x7dq1sy4	140	1	Hence	hence	RB
cord-259748-x7dq1sy4	140	2	,	,	,
cord-259748-x7dq1sy4	140	3	STING	STING	NNP
cord-259748-x7dq1sy4	140	4	and	and	CC
cord-259748-x7dq1sy4	140	5	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	140	6	can	can	MD
cord-259748-x7dq1sy4	140	7	aggregate	aggregate	VB
cord-259748-x7dq1sy4	140	8	on	on	IN
cord-259748-x7dq1sy4	140	9	the	the	DT
cord-259748-x7dq1sy4	140	10	Golgi	Golgi	NNP
cord-259748-x7dq1sy4	140	11	to	to	TO
cord-259748-x7dq1sy4	140	12	form	form	VB
cord-259748-x7dq1sy4	140	13	the	the	DT
cord-259748-x7dq1sy4	140	14	STING	sting	NN
cord-259748-x7dq1sy4	140	15	signalosome	signalosome	NN
cord-259748-x7dq1sy4	140	16	.	.	.
cord-259748-x7dq1sy4	141	1	Clustering	cluster	VBG
cord-259748-x7dq1sy4	141	2	STING	sting	NN
cord-259748-x7dq1sy4	141	3	undergoes	undergo	VBZ
cord-259748-x7dq1sy4	141	4	palmitoylation	palmitoylation	NN
cord-259748-x7dq1sy4	141	5	and	and	CC
cord-259748-x7dq1sy4	141	6	full	full	JJ
cord-259748-x7dq1sy4	141	7	activation	activation	NN
cord-259748-x7dq1sy4	141	8	(	(	-LRB-
cord-259748-x7dq1sy4	141	9	74	74	CD
cord-259748-x7dq1sy4	141	10	)	)	-RRB-
cord-259748-x7dq1sy4	141	11	.	.	.
cord-259748-x7dq1sy4	142	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	142	2	is	be	VBZ
cord-259748-x7dq1sy4	142	3	also	also	RB
cord-259748-x7dq1sy4	142	4	possible	possible	JJ
cord-259748-x7dq1sy4	142	5	for	for	IN
cord-259748-x7dq1sy4	142	6	STING	sting	NN
cord-259748-x7dq1sy4	142	7	-	-	HYPH
cord-259748-x7dq1sy4	142	8	IKK	IKK	NNP
cord-259748-x7dq1sy4	142	9	to	to	TO
cord-259748-x7dq1sy4	142	10	cluster	cluster	VB
cord-259748-x7dq1sy4	142	11	and	and	CC
cord-259748-x7dq1sy4	142	12	form	form	VB
cord-259748-x7dq1sy4	142	13	the	the	DT
cord-259748-x7dq1sy4	142	14	STING	sting	NN
cord-259748-x7dq1sy4	142	15	signalosome	signalosome	NN
cord-259748-x7dq1sy4	142	16	in	in	IN
cord-259748-x7dq1sy4	142	17	this	this	DT
cord-259748-x7dq1sy4	142	18	manner	manner	NN
cord-259748-x7dq1sy4	142	19	.	.	.
cord-259748-x7dq1sy4	143	1	The	the	DT
cord-259748-x7dq1sy4	143	2	STING	STING	NNP
cord-259748-x7dq1sy4	143	3	-	-	HYPH
cord-259748-x7dq1sy4	143	4	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	143	5	/	/	SYM
cord-259748-x7dq1sy4	143	6	IKK	IKK	NNP
cord-259748-x7dq1sy4	143	7	signalosome	signalosome	NN
cord-259748-x7dq1sy4	143	8	produces	produce	VBZ
cord-259748-x7dq1sy4	143	9	a	a	DT
cord-259748-x7dq1sy4	143	10	scaffold	scaffold	NN
cord-259748-x7dq1sy4	143	11	to	to	TO
cord-259748-x7dq1sy4	143	12	phosphorylate	phosphorylate	VB
cord-259748-x7dq1sy4	143	13	interferon	interferon	NN
cord-259748-x7dq1sy4	143	14	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	143	15	factor	factor	NN
cord-259748-x7dq1sy4	143	16	3	3	CD
cord-259748-x7dq1sy4	143	17	(	(	-LRB-
cord-259748-x7dq1sy4	143	18	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	143	19	)	)	-RRB-
cord-259748-x7dq1sy4	143	20	or	or	CC
cord-259748-x7dq1sy4	143	21	inhibitor	inhibitor	NN
cord-259748-x7dq1sy4	143	22	of	of	IN
cord-259748-x7dq1sy4	143	23	NF	nf	NN
cord-259748-x7dq1sy4	143	24	-	-	HYPH
cord-259748-x7dq1sy4	143	25	κBα	κBα	NNP
cord-259748-x7dq1sy4	143	26	(	(	-LRB-
cord-259748-x7dq1sy4	143	27	IκBα	IκBα	NNP
cord-259748-x7dq1sy4	143	28	)	)	-RRB-
cord-259748-x7dq1sy4	143	29	.	.	.
cord-259748-x7dq1sy4	144	1	Activated	activate	VBN
cord-259748-x7dq1sy4	144	2	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	144	3	undergo	undergo	VBP
cord-259748-x7dq1sy4	144	4	dimerization	dimerization	NN
cord-259748-x7dq1sy4	144	5	(	(	-LRB-
cord-259748-x7dq1sy4	144	6	70	70	CD
cord-259748-x7dq1sy4	144	7	)	)	-RRB-
cord-259748-x7dq1sy4	144	8	.	.	.
cord-259748-x7dq1sy4	145	1	The	the	DT
cord-259748-x7dq1sy4	145	2	activation	activation	NN
cord-259748-x7dq1sy4	145	3	of	of	IN
cord-259748-x7dq1sy4	145	4	IκBα	IκBα	NNP
cord-259748-x7dq1sy4	145	5	leads	lead	VBZ
cord-259748-x7dq1sy4	145	6	to	to	IN
cord-259748-x7dq1sy4	145	7	its	-PRON-	PRP$
cord-259748-x7dq1sy4	145	8	polyubiquitination	polyubiquitination	NN
cord-259748-x7dq1sy4	145	9	and	and	CC
cord-259748-x7dq1sy4	145	10	degradation	degradation	NN
cord-259748-x7dq1sy4	145	11	by	by	IN
cord-259748-x7dq1sy4	145	12	the	the	DT
cord-259748-x7dq1sy4	145	13	proteosome	proteosome	NN
cord-259748-x7dq1sy4	145	14	,	,	,
cord-259748-x7dq1sy4	145	15	thereby	thereby	RB
cord-259748-x7dq1sy4	145	16	eliminating	eliminate	VBG
cord-259748-x7dq1sy4	145	17	its	-PRON-	PRP$
cord-259748-x7dq1sy4	145	18	inhibition	inhibition	NN
cord-259748-x7dq1sy4	145	19	of	of	IN
cord-259748-x7dq1sy4	145	20	NF	nf	NN
cord-259748-x7dq1sy4	145	21	-	-	HYPH
cord-259748-x7dq1sy4	145	22	κB.	κb.	JJ
cord-259748-x7dq1sy4	146	1	There	there	EX
cord-259748-x7dq1sy4	146	2	is	be	VBZ
cord-259748-x7dq1sy4	146	3	also	also	RB
cord-259748-x7dq1sy4	146	4	evidence	evidence	NN
cord-259748-x7dq1sy4	146	5	suggesting	suggest	VBG
cord-259748-x7dq1sy4	146	6	that	that	IN
cord-259748-x7dq1sy4	146	7	NF	nf	NN
cord-259748-x7dq1sy4	146	8	-	-	HYPH
cord-259748-x7dq1sy4	146	9	κB	κb	CD
cord-259748-x7dq1sy4	146	10	activation	activation	NN
cord-259748-x7dq1sy4	146	11	might	may	MD
cord-259748-x7dq1sy4	146	12	not	not	RB
cord-259748-x7dq1sy4	146	13	require	require	VB
cord-259748-x7dq1sy4	146	14	STING	sting	NN
cord-259748-x7dq1sy4	146	15	trafficking	trafficking	NN
cord-259748-x7dq1sy4	146	16	from	from	IN
cord-259748-x7dq1sy4	146	17	the	the	DT
cord-259748-x7dq1sy4	146	18	ER	ER	NNP
cord-259748-x7dq1sy4	146	19	(	(	-LRB-
cord-259748-x7dq1sy4	146	20	75	75	CD
cord-259748-x7dq1sy4	146	21	)	)	-RRB-
cord-259748-x7dq1sy4	146	22	.	.	.
cord-259748-x7dq1sy4	147	1	Then	then	RB
cord-259748-x7dq1sy4	147	2	,	,	,
cord-259748-x7dq1sy4	147	3	the	the	DT
cord-259748-x7dq1sy4	147	4	dimerized	dimerized	JJ
cord-259748-x7dq1sy4	147	5	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	147	6	or	or	CC
cord-259748-x7dq1sy4	147	7	activated	activate	VBN
cord-259748-x7dq1sy4	147	8	NF	nf	NN
cord-259748-x7dq1sy4	147	9	-	-	HYPH
cord-259748-x7dq1sy4	147	10	κB	κb	CD
cord-259748-x7dq1sy4	147	11	p50	p50	NN
cord-259748-x7dq1sy4	147	12	/	/	SYM
cord-259748-x7dq1sy4	147	13	p65	p65	NN
cord-259748-x7dq1sy4	148	1	(	(	-LRB-
cord-259748-x7dq1sy4	148	2	p65	p65	NN
cord-259748-x7dq1sy4	148	3	is	be	VBZ
cord-259748-x7dq1sy4	148	4	also	also	RB
cord-259748-x7dq1sy4	148	5	known	know	VBN
cord-259748-x7dq1sy4	148	6	as	as	IN
cord-259748-x7dq1sy4	148	7	RelA	RelA	NNP
cord-259748-x7dq1sy4	148	8	)	)	-RRB-
cord-259748-x7dq1sy4	149	1	complex	complex	NNP
cord-259748-x7dq1sy4	149	2	are	be	VBP
cord-259748-x7dq1sy4	149	3	translocated	translocate	VBN
cord-259748-x7dq1sy4	149	4	into	into	IN
cord-259748-x7dq1sy4	149	5	the	the	DT
cord-259748-x7dq1sy4	149	6	nucleus	nucleus	NN
cord-259748-x7dq1sy4	149	7	as	as	IN
cord-259748-x7dq1sy4	149	8	transcription	transcription	NN
cord-259748-x7dq1sy4	149	9	factors	factor	NNS
cord-259748-x7dq1sy4	149	10	and	and	CC
cord-259748-x7dq1sy4	149	11	bind	bind	VB
cord-259748-x7dq1sy4	149	12	to	to	IN
cord-259748-x7dq1sy4	149	13	the	the	DT
cord-259748-x7dq1sy4	149	14	promoter	promoter	NN
cord-259748-x7dq1sy4	149	15	of	of	IN
cord-259748-x7dq1sy4	149	16	type	type	NN
cord-259748-x7dq1sy4	150	1	-I	-I	NFP
cord-259748-x7dq1sy4	150	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	150	3	to	to	TO
cord-259748-x7dq1sy4	150	4	aid	aid	VB
cord-259748-x7dq1sy4	150	5	the	the	DT
cord-259748-x7dq1sy4	150	6	transcription	transcription	NN
cord-259748-x7dq1sy4	150	7	of	of	IN
cord-259748-x7dq1sy4	150	8	type	type	NN
cord-259748-x7dq1sy4	150	9	-	-	:
cord-259748-x7dq1sy4	150	10	I	-PRON-	PRP
cord-259748-x7dq1sy4	150	11	IFN	IFN	NNP
cord-259748-x7dq1sy4	150	12	(	(	-LRB-
cord-259748-x7dq1sy4	150	13	2	2	CD
cord-259748-x7dq1sy4	150	14	,	,	,
cord-259748-x7dq1sy4	150	15	3	3	CD
cord-259748-x7dq1sy4	150	16	,	,	,
cord-259748-x7dq1sy4	150	17	70	70	CD
cord-259748-x7dq1sy4	150	18	)	)	-RRB-
cord-259748-x7dq1sy4	150	19	.	.	.
cord-259748-x7dq1sy4	151	1	Meanwhile	meanwhile	RB
cord-259748-x7dq1sy4	151	2	,	,	,
cord-259748-x7dq1sy4	151	3	activation	activation	NN
cord-259748-x7dq1sy4	151	4	of	of	IN
cord-259748-x7dq1sy4	151	5	NF	nf	NN
cord-259748-x7dq1sy4	151	6	-	-	HYPH
cord-259748-x7dq1sy4	151	7	κB	κb	CD
cord-259748-x7dq1sy4	151	8	p52	p52	NN
cord-259748-x7dq1sy4	151	9	/	/	SYM
cord-259748-x7dq1sy4	151	10	RelB	RelB	NNP
cord-259748-x7dq1sy4	151	11	can	can	MD
cord-259748-x7dq1sy4	151	12	prevent	prevent	VB
cord-259748-x7dq1sy4	151	13	recruitment	recruitment	NN
cord-259748-x7dq1sy4	151	14	of	of	IN
cord-259748-x7dq1sy4	151	15	p65	p65	NN
cord-259748-x7dq1sy4	151	16	and	and	CC
cord-259748-x7dq1sy4	151	17	inhibit	inhibit	VB
cord-259748-x7dq1sy4	151	18	the	the	DT
cord-259748-x7dq1sy4	151	19	p50	p50	NN
cord-259748-x7dq1sy4	151	20	/	/	SYM
cord-259748-x7dq1sy4	151	21	p65	p65	NN
cord-259748-x7dq1sy4	151	22	signal	signal	NN
cord-259748-x7dq1sy4	151	23	(	(	-LRB-
cord-259748-x7dq1sy4	151	24	76	76	CD
cord-259748-x7dq1sy4	151	25	)	)	-RRB-
cord-259748-x7dq1sy4	151	26	(	(	-LRB-
cord-259748-x7dq1sy4	151	27	Figure	figure	NN
cord-259748-x7dq1sy4	151	28	2C	2c	NN
cord-259748-x7dq1sy4	151	29	)	)	-RRB-
cord-259748-x7dq1sy4	151	30	.	.	.
cord-259748-x7dq1sy4	152	1	Expressed	express	VBN
cord-259748-x7dq1sy4	152	2	type	type	NN
cord-259748-x7dq1sy4	152	3	-	-	:
cord-259748-x7dq1sy4	152	4	I	-PRON-	PRP
cord-259748-x7dq1sy4	152	5	IFN	IFN	NNP
cord-259748-x7dq1sy4	152	6	can	can	MD
cord-259748-x7dq1sy4	152	7	propagate	propagate	VB
cord-259748-x7dq1sy4	152	8	among	among	IN
cord-259748-x7dq1sy4	152	9	cells	cell	NNS
cord-259748-x7dq1sy4	152	10	in	in	IN
cord-259748-x7dq1sy4	152	11	paracrine	paracrine	NN
cord-259748-x7dq1sy4	152	12	or	or	CC
cord-259748-x7dq1sy4	152	13	autocrine	autocrine	JJ
cord-259748-x7dq1sy4	152	14	manners	manner	NNS
cord-259748-x7dq1sy4	152	15	.	.	.
cord-259748-x7dq1sy4	153	1	The	the	DT
cord-259748-x7dq1sy4	153	2	binding	binding	NN
cord-259748-x7dq1sy4	153	3	of	of	IN
cord-259748-x7dq1sy4	153	4	IFNα	IFNα	NNP
cord-259748-x7dq1sy4	153	5	/	/	SYM
cord-259748-x7dq1sy4	153	6	β	β	XX
cord-259748-x7dq1sy4	153	7	with	with	IN
cord-259748-x7dq1sy4	153	8	its	-PRON-	PRP$
cord-259748-x7dq1sy4	153	9	receptor	receptor	NN
cord-259748-x7dq1sy4	153	10	triggers	trigger	VBZ
cord-259748-x7dq1sy4	153	11	janus	janus	NNP
cord-259748-x7dq1sy4	153	12	kinase	kinase	NNP
cord-259748-x7dq1sy4	153	13	(	(	-LRB-
cord-259748-x7dq1sy4	153	14	JAK	JAK	NNP
cord-259748-x7dq1sy4	153	15	)	)	-RRB-
cord-259748-x7dq1sy4	153	16	and	and	CC
cord-259748-x7dq1sy4	153	17	signal	signal	NN
cord-259748-x7dq1sy4	153	18	transducer	transducer	NN
cord-259748-x7dq1sy4	153	19	and	and	CC
cord-259748-x7dq1sy4	153	20	activator	activator	NN
cord-259748-x7dq1sy4	153	21	of	of	IN
cord-259748-x7dq1sy4	153	22	transcription	transcription	NN
cord-259748-x7dq1sy4	153	23	(	(	-LRB-
cord-259748-x7dq1sy4	153	24	STAT	stat	NN
cord-259748-x7dq1sy4	153	25	)	)	-RRB-
cord-259748-x7dq1sy4	153	26	pathways	pathway	NNS
cord-259748-x7dq1sy4	153	27	,	,	,
cord-259748-x7dq1sy4	153	28	then	then	RB
cord-259748-x7dq1sy4	153	29	induce	induce	VB
cord-259748-x7dq1sy4	153	30	transcription	transcription	NN
cord-259748-x7dq1sy4	153	31	of	of	IN
cord-259748-x7dq1sy4	153	32	type	type	NN
cord-259748-x7dq1sy4	153	33	-	-	:
cord-259748-x7dq1sy4	153	34	I	-PRON-	PRP
cord-259748-x7dq1sy4	153	35	IFN	IFN	NNP
cord-259748-x7dq1sy4	153	36	-	-	HYPH
cord-259748-x7dq1sy4	153	37	stimulated	stimulate	VBN
cord-259748-x7dq1sy4	153	38	genes	gene	NNS
cord-259748-x7dq1sy4	153	39	(	(	-LRB-
cord-259748-x7dq1sy4	153	40	ISGs	ISGs	NNP
cord-259748-x7dq1sy4	153	41	)	)	-RRB-
cord-259748-x7dq1sy4	153	42	,	,	,
cord-259748-x7dq1sy4	153	43	which	which	WDT
cord-259748-x7dq1sy4	153	44	have	have	VBP
cord-259748-x7dq1sy4	153	45	IFN	IFN	NNP
cord-259748-x7dq1sy4	153	46	-	-	HYPH
cord-259748-x7dq1sy4	153	47	sensitive	sensitive	JJ
cord-259748-x7dq1sy4	153	48	response	response	NN
cord-259748-x7dq1sy4	153	49	elements	element	NNS
cord-259748-x7dq1sy4	153	50	(	(	-LRB-
cord-259748-x7dq1sy4	153	51	ISREs	ISREs	NNP
cord-259748-x7dq1sy4	153	52	)	)	-RRB-
cord-259748-x7dq1sy4	153	53	in	in	IN
cord-259748-x7dq1sy4	153	54	their	-PRON-	PRP$
cord-259748-x7dq1sy4	153	55	5	5	CD
cord-259748-x7dq1sy4	153	56	-untranslated	-untranslated	JJ
cord-259748-x7dq1sy4	153	57	regions	region	NNS
cord-259748-x7dq1sy4	153	58	(	(	-LRB-
cord-259748-x7dq1sy4	153	59	UTRs	UTRs	NNP
cord-259748-x7dq1sy4	153	60	)	)	-RRB-
cord-259748-x7dq1sy4	153	61	(	(	-LRB-
cord-259748-x7dq1sy4	153	62	77	77	CD
cord-259748-x7dq1sy4	153	63	)	)	-RRB-
cord-259748-x7dq1sy4	153	64	.	.	.
cord-259748-x7dq1sy4	154	1	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	154	2	can	can	MD
cord-259748-x7dq1sy4	154	3	also	also	RB
cord-259748-x7dq1sy4	154	4	bind	bind	VB
cord-259748-x7dq1sy4	154	5	partially	partially	RB
cord-259748-x7dq1sy4	154	6	to	to	IN
cord-259748-x7dq1sy4	154	7	several	several	JJ
cord-259748-x7dq1sy4	154	8	ISREs	isre	NNS
cord-259748-x7dq1sy4	154	9	alone	alone	JJ
cord-259748-x7dq1sy4	154	10	(	(	-LRB-
cord-259748-x7dq1sy4	154	11	78	78	CD
cord-259748-x7dq1sy4	154	12	)	)	-RRB-
cord-259748-x7dq1sy4	154	13	.	.	.
cord-259748-x7dq1sy4	155	1	Herein	herein	RB
cord-259748-x7dq1sy4	155	2	,	,	,
cord-259748-x7dq1sy4	155	3	the	the	DT
cord-259748-x7dq1sy4	155	4	expression	expression	NN
cord-259748-x7dq1sy4	155	5	of	of	IN
cord-259748-x7dq1sy4	155	6	some	some	DT
cord-259748-x7dq1sy4	155	7	ISGs	isg	NNS
cord-259748-x7dq1sy4	155	8	including	include	VBG
cord-259748-x7dq1sy4	155	9	interferon	interferon	NN
cord-259748-x7dq1sy4	155	10	-	-	HYPH
cord-259748-x7dq1sy4	155	11	induced	induce	VBN
cord-259748-x7dq1sy4	155	12	protein	protein	NN
cord-259748-x7dq1sy4	155	13	with	with	IN
cord-259748-x7dq1sy4	155	14	tetratricopeptide	tetratricopeptide	JJ
cord-259748-x7dq1sy4	155	15	repeats	repeat	VBZ
cord-259748-x7dq1sy4	155	16	(	(	-LRB-
cord-259748-x7dq1sy4	155	17	IFIT	IFIT	NNP
cord-259748-x7dq1sy4	155	18	)	)	-RRB-
cord-259748-x7dq1sy4	155	19	and	and	CC
cord-259748-x7dq1sy4	155	20	pro	pro	JJ
cord-259748-x7dq1sy4	155	21	-	-	JJ
cord-259748-x7dq1sy4	155	22	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	155	23	cytokines	cytokine	NNS
cord-259748-x7dq1sy4	155	24	such	such	JJ
cord-259748-x7dq1sy4	155	25	as	as	IN
cord-259748-x7dq1sy4	155	26	tumor	tumor	NN
cord-259748-x7dq1sy4	155	27	necrosis	necrosis	NN
cord-259748-x7dq1sy4	155	28	factor	factor	NN
cord-259748-x7dq1sy4	155	29	α	α	NNP
cord-259748-x7dq1sy4	155	30	(	(	-LRB-
cord-259748-x7dq1sy4	155	31	TNFα	TNFα	NNP
cord-259748-x7dq1sy4	155	32	)	)	-RRB-
cord-259748-x7dq1sy4	155	33	,	,	,
cord-259748-x7dq1sy4	155	34	interleukin	interleukin	FW
cord-259748-x7dq1sy4	155	35	(	(	-LRB-
cord-259748-x7dq1sy4	155	36	IL)-6	IL)-6	NNP
cord-259748-x7dq1sy4	155	37	,	,	,
cord-259748-x7dq1sy4	155	38	C	C	NNP
cord-259748-x7dq1sy4	155	39	-	-	HYPH
cord-259748-x7dq1sy4	155	40	X	X	NNP
cord-259748-x7dq1sy4	155	41	-	-	HYPH
cord-259748-x7dq1sy4	155	42	C	c	NN
cord-259748-x7dq1sy4	155	43	motif	motif	NN
cord-259748-x7dq1sy4	155	44	chemokine	chemokine	NN
cord-259748-x7dq1sy4	155	45	ligand	ligand	NN
cord-259748-x7dq1sy4	155	46	10	10	CD
cord-259748-x7dq1sy4	155	47	(	(	-LRB-
cord-259748-x7dq1sy4	155	48	CXCL10	CXCL10	NNP
cord-259748-x7dq1sy4	155	49	)	)	-RRB-
cord-259748-x7dq1sy4	155	50	and	and	CC
cord-259748-x7dq1sy4	155	51	C	C	NNP
cord-259748-x7dq1sy4	155	52	-	-	HYPH
cord-259748-x7dq1sy4	155	53	C	C	NNP
cord-259748-x7dq1sy4	155	54	motif	motif	NN
cord-259748-x7dq1sy4	155	55	chemokine	chemokine	NN
cord-259748-x7dq1sy4	155	56	ligand	ligand	NN
cord-259748-x7dq1sy4	155	57	5	5	CD
cord-259748-x7dq1sy4	155	58	(	(	-LRB-
cord-259748-x7dq1sy4	155	59	CCL5	CCL5	NNP
cord-259748-x7dq1sy4	155	60	)	)	-RRB-
cord-259748-x7dq1sy4	155	61	is	be	VBZ
cord-259748-x7dq1sy4	155	62	increased	increase	VBN
cord-259748-x7dq1sy4	155	63	remarkably	remarkably	RB
cord-259748-x7dq1sy4	155	64	by	by	IN
cord-259748-x7dq1sy4	155	65	the	the	DT
cord-259748-x7dq1sy4	155	66	cGAS	cgas	JJ
cord-259748-x7dq1sy4	155	67	-	-	HYPH
cord-259748-x7dq1sy4	155	68	STING	sting	NN
cord-259748-x7dq1sy4	155	69	pathway	pathway	NN
cord-259748-x7dq1sy4	155	70	(	(	-LRB-
cord-259748-x7dq1sy4	155	71	79	79	CD
cord-259748-x7dq1sy4	155	72	)	)	-RRB-
cord-259748-x7dq1sy4	155	73	.	.	.
cord-259748-x7dq1sy4	156	1	Furthermore	furthermore	RB
cord-259748-x7dq1sy4	156	2	,	,	,
cord-259748-x7dq1sy4	156	3	cGAS	cgas	NN
cord-259748-x7dq1sy4	156	4	and	and	CC
cord-259748-x7dq1sy4	156	5	STING	sting	NN
cord-259748-x7dq1sy4	156	6	are	be	VBP
cord-259748-x7dq1sy4	156	7	both	both	DT
cord-259748-x7dq1sy4	156	8	ISGs	isg	NNS
cord-259748-x7dq1sy4	156	9	,	,	,
cord-259748-x7dq1sy4	156	10	suggesting	suggest	VBG
cord-259748-x7dq1sy4	156	11	a	a	DT
cord-259748-x7dq1sy4	156	12	positive	positive	JJ
cord-259748-x7dq1sy4	156	13	feedback	feedback	NN
cord-259748-x7dq1sy4	156	14	loop	loop	NN
cord-259748-x7dq1sy4	156	15	in	in	IN
cord-259748-x7dq1sy4	156	16	spreading	spreading	NN
cord-259748-x7dq1sy4	156	17	of	of	IN
cord-259748-x7dq1sy4	156	18	the	the	DT
cord-259748-x7dq1sy4	156	19	IFN	IFN	NNP
cord-259748-x7dq1sy4	156	20	signal	signal	NN
cord-259748-x7dq1sy4	156	21	(	(	-LRB-
cord-259748-x7dq1sy4	156	22	80	80	CD
cord-259748-x7dq1sy4	156	23	,	,	,
cord-259748-x7dq1sy4	156	24	81	81	CD
cord-259748-x7dq1sy4	156	25	)	)	-RRB-
cord-259748-x7dq1sy4	156	26	.	.	.
cord-259748-x7dq1sy4	157	1	Stimulator	Stimulator	NNP
cord-259748-x7dq1sy4	157	2	of	of	IN
cord-259748-x7dq1sy4	157	3	interferon	interferon	NN
cord-259748-x7dq1sy4	157	4	genes	gene	NNS
cord-259748-x7dq1sy4	157	5	activation	activation	NN
cord-259748-x7dq1sy4	157	6	on	on	IN
cord-259748-x7dq1sy4	157	7	the	the	DT
cord-259748-x7dq1sy4	157	8	ER	ER	NNP
cord-259748-x7dq1sy4	157	9	also	also	RB
cord-259748-x7dq1sy4	157	10	triggers	trigger	VBZ
cord-259748-x7dq1sy4	157	11	an	an	DT
cord-259748-x7dq1sy4	157	12	ER	ER	NNP
cord-259748-x7dq1sy4	157	13	stress	stress	NN
cord-259748-x7dq1sy4	157	14	response	response	NN
cord-259748-x7dq1sy4	157	15	with	with	IN
cord-259748-x7dq1sy4	157	16	an	an	DT
cord-259748-x7dq1sy4	157	17	"	"	``
cord-259748-x7dq1sy4	157	18	unfolded	unfold	VBN
cord-259748-x7dq1sy4	157	19	protein	protein	NN
cord-259748-x7dq1sy4	157	20	response	response	NN
cord-259748-x7dq1sy4	157	21	(	(	-LRB-
cord-259748-x7dq1sy4	157	22	UPR	UPR	NNP
cord-259748-x7dq1sy4	157	23	)	)	-RRB-
cord-259748-x7dq1sy4	157	24	motif	motif	NN
cord-259748-x7dq1sy4	157	25	"	"	''
cord-259748-x7dq1sy4	157	26	on	on	IN
cord-259748-x7dq1sy4	157	27	the	the	DT
cord-259748-x7dq1sy4	157	28	C	c	NN
cord-259748-x7dq1sy4	157	29	-	-	HYPH
cord-259748-x7dq1sy4	157	30	terminus	terminus	NN
cord-259748-x7dq1sy4	157	31	of	of	IN
cord-259748-x7dq1sy4	157	32	STING	sting	NN
cord-259748-x7dq1sy4	157	33	,	,	,
cord-259748-x7dq1sy4	157	34	which	which	WDT
cord-259748-x7dq1sy4	157	35	leads	lead	VBZ
cord-259748-x7dq1sy4	157	36	to	to	IN
cord-259748-x7dq1sy4	157	37	and	and	CC
cord-259748-x7dq1sy4	157	38	ER	ER	NNP
cord-259748-x7dq1sy4	157	39	stress	stress	NN
cord-259748-x7dq1sy4	157	40	-	-	HYPH
cord-259748-x7dq1sy4	157	41	mediated	mediate	VBN
cord-259748-x7dq1sy4	157	42	autophagy	autophagy	NN
cord-259748-x7dq1sy4	157	43	(	(	-LRB-
cord-259748-x7dq1sy4	157	44	82	82	CD
cord-259748-x7dq1sy4	157	45	,	,	,
cord-259748-x7dq1sy4	157	46	83	83	CD
cord-259748-x7dq1sy4	157	47	)	)	-RRB-
cord-259748-x7dq1sy4	157	48	.	.	.
cord-259748-x7dq1sy4	158	1	STING	STING	NNP
cord-259748-x7dq1sy4	158	2	-	-	HYPH
cord-259748-x7dq1sy4	158	3	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	158	4	activation	activation	NN
cord-259748-x7dq1sy4	158	5	and	and	CC
cord-259748-x7dq1sy4	158	6	ER	ER	NNP
cord-259748-x7dq1sy4	158	7	stress	stress	NN
cord-259748-x7dq1sy4	158	8	also	also	RB
cord-259748-x7dq1sy4	158	9	induce	induce	VBP
cord-259748-x7dq1sy4	158	10	mechanistic	mechanistic	JJ
cord-259748-x7dq1sy4	158	11	target	target	NN
cord-259748-x7dq1sy4	158	12	of	of	IN
cord-259748-x7dq1sy4	158	13	rapamycin	rapamycin	NN
cord-259748-x7dq1sy4	158	14	complex	complex	NNP
cord-259748-x7dq1sy4	158	15	1	1	CD
cord-259748-x7dq1sy4	158	16	(	(	-LRB-
cord-259748-x7dq1sy4	158	17	mTORC1	mTORC1	NNP
cord-259748-x7dq1sy4	158	18	)	)	-RRB-
cord-259748-x7dq1sy4	158	19	dysfunction	dysfunction	NN
cord-259748-x7dq1sy4	158	20	(	(	-LRB-
cord-259748-x7dq1sy4	158	21	84	84	CD
cord-259748-x7dq1sy4	158	22	)	)	-RRB-
cord-259748-x7dq1sy4	158	23	.	.	.
cord-259748-x7dq1sy4	159	1	ER	ER	NNP
cord-259748-x7dq1sy4	159	2	stress	stress	NN
cord-259748-x7dq1sy4	159	3	or	or	CC
cord-259748-x7dq1sy4	159	4	reduced	reduce	VBN
cord-259748-x7dq1sy4	159	5	mTORC1	mtorc1	CD
cord-259748-x7dq1sy4	160	1	signaling	signal	VBG
cord-259748-x7dq1sy4	160	2	activates	activate	VBZ
cord-259748-x7dq1sy4	160	3	Unc-51-likeautophagy	Unc-51-likeautophagy	NNP
cord-259748-x7dq1sy4	160	4	activating	activate	VBG
cord-259748-x7dq1sy4	160	5	kinase	kinase	NN
cord-259748-x7dq1sy4	160	6	(	(	-LRB-
cord-259748-x7dq1sy4	160	7	ULK1	ULK1	NNP
cord-259748-x7dq1sy4	160	8	)	)	-RRB-
cord-259748-x7dq1sy4	160	9	complex	complex	NN
cord-259748-x7dq1sy4	160	10	and	and	CC
cord-259748-x7dq1sy4	160	11	the	the	DT
cord-259748-x7dq1sy4	160	12	Beclin-1-class	Beclin-1-class	NNP
cord-259748-x7dq1sy4	160	13	III	III	NNP
cord-259748-x7dq1sy4	160	14	phosphatylinositol	phosphatylinositol	NNP
cord-259748-x7dq1sy4	161	1	3-kinase	3-kinase	LS
cord-259748-x7dq1sy4	161	2	(	(	-LRB-
cord-259748-x7dq1sy4	161	3	PI3KC3	pi3kc3	NN
cord-259748-x7dq1sy4	161	4	also	also	RB
cord-259748-x7dq1sy4	161	5	known	know	VBN
cord-259748-x7dq1sy4	161	6	as	as	IN
cord-259748-x7dq1sy4	161	7	VPS34	VPS34	NNP
cord-259748-x7dq1sy4	161	8	)	)	-RRB-
cord-259748-x7dq1sy4	161	9	complex	complex	NN
cord-259748-x7dq1sy4	161	10	,	,	,
cord-259748-x7dq1sy4	161	11	which	which	WDT
cord-259748-x7dq1sy4	161	12	promotes	promote	VBZ
cord-259748-x7dq1sy4	161	13	initiation	initiation	NN
cord-259748-x7dq1sy4	161	14	of	of	IN
cord-259748-x7dq1sy4	161	15	the	the	DT
cord-259748-x7dq1sy4	161	16	classical	classical	JJ
cord-259748-x7dq1sy4	161	17	autophagy	autophagy	NN
cord-259748-x7dq1sy4	161	18	path	path	NN
cord-259748-x7dq1sy4	161	19	(	(	-LRB-
cord-259748-x7dq1sy4	161	20	85	85	CD
cord-259748-x7dq1sy4	161	21	)	)	-RRB-
cord-259748-x7dq1sy4	161	22	.	.	.
cord-259748-x7dq1sy4	162	1	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	162	2	can	can	MD
cord-259748-x7dq1sy4	162	3	also	also	RB
cord-259748-x7dq1sy4	162	4	interact	interact	VB
cord-259748-x7dq1sy4	162	5	directly	directly	RB
cord-259748-x7dq1sy4	162	6	with	with	IN
cord-259748-x7dq1sy4	162	7	the	the	DT
cord-259748-x7dq1sy4	162	8	autophagy	autophagy	NN
cord-259748-x7dq1sy4	162	9	protein	protein	NN
cord-259748-x7dq1sy4	162	10	beclin-1-PI3KC3	beclin-1-PI3KC3	NNP
cord-259748-x7dq1sy4	162	11	complex	complex	NN
cord-259748-x7dq1sy4	162	12	and	and	CC
cord-259748-x7dq1sy4	162	13	trigger	trigger	NN
cord-259748-x7dq1sy4	162	14	autophagy	autophagy	NN
cord-259748-x7dq1sy4	162	15	(	(	-LRB-
cord-259748-x7dq1sy4	162	16	86	86	CD
cord-259748-x7dq1sy4	162	17	)	)	-RRB-
cord-259748-x7dq1sy4	162	18	.	.	.
cord-259748-x7dq1sy4	163	1	Furthermore	furthermore	RB
cord-259748-x7dq1sy4	163	2	,	,	,
cord-259748-x7dq1sy4	163	3	cGAS	cgas	JJ
cord-259748-x7dq1sy4	163	4	-	-	HYPH
cord-259748-x7dq1sy4	163	5	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	163	6	polymer	polymer	NN
cord-259748-x7dq1sy4	163	7	can	can	MD
cord-259748-x7dq1sy4	163	8	form	form	VB
cord-259748-x7dq1sy4	163	9	a	a	DT
cord-259748-x7dq1sy4	163	10	liquid	liquid	JJ
cord-259748-x7dq1sy4	163	11	-	-	HYPH
cord-259748-x7dq1sy4	163	12	phase	phase	NN
cord-259748-x7dq1sy4	163	13	condensate	condensate	NN
cord-259748-x7dq1sy4	163	14	(	(	-LRB-
cord-259748-x7dq1sy4	163	15	as	as	IN
cord-259748-x7dq1sy4	163	16	mentioned	mention	VBN
cord-259748-x7dq1sy4	163	17	above	above	RB
cord-259748-x7dq1sy4	163	18	)	)	-RRB-
cord-259748-x7dq1sy4	163	19	,	,	,
cord-259748-x7dq1sy4	163	20	which	which	WDT
cord-259748-x7dq1sy4	163	21	could	could	MD
cord-259748-x7dq1sy4	163	22	theoretically	theoretically	RB
cord-259748-x7dq1sy4	163	23	be	be	VB
cord-259748-x7dq1sy4	163	24	an	an	DT
cord-259748-x7dq1sy4	163	25	initiator	initiator	NN
cord-259748-x7dq1sy4	163	26	of	of	IN
cord-259748-x7dq1sy4	163	27	autophagy	autophagy	NN
cord-259748-x7dq1sy4	163	28	(	(	-LRB-
cord-259748-x7dq1sy4	163	29	87	87	CD
cord-259748-x7dq1sy4	163	30	)	)	-RRB-
cord-259748-x7dq1sy4	163	31	.	.	.
cord-259748-x7dq1sy4	164	1	After	after	IN
cord-259748-x7dq1sy4	164	2	autophagy	autophagy	NN
cord-259748-x7dq1sy4	164	3	initiation	initiation	NN
cord-259748-x7dq1sy4	164	4	,	,	,
cord-259748-x7dq1sy4	164	5	autophagy	autophagy	NN
cord-259748-x7dq1sy4	164	6	-	-	HYPH
cord-259748-x7dq1sy4	164	7	related	relate	VBN
cord-259748-x7dq1sy4	164	8	protein	protein	NN
cord-259748-x7dq1sy4	164	9	9	9	CD
cord-259748-x7dq1sy4	164	10	(	(	-LRB-
cord-259748-x7dq1sy4	164	11	ATG9	ATG9	NNP
cord-259748-x7dq1sy4	164	12	)	)	-RRB-
cord-259748-x7dq1sy4	164	13	undertakes	undertake	VBZ
cord-259748-x7dq1sy4	164	14	the	the	DT
cord-259748-x7dq1sy4	164	15	genesis	genesis	NN
cord-259748-x7dq1sy4	164	16	of	of	IN
cord-259748-x7dq1sy4	164	17	the	the	DT
cord-259748-x7dq1sy4	164	18	autophagosome	autophagosome	NNP
cord-259748-x7dq1sy4	164	19	along	along	IN
cord-259748-x7dq1sy4	164	20	with	with	IN
cord-259748-x7dq1sy4	164	21	light	light	JJ
cord-259748-x7dq1sy4	164	22	chain3	chain3	NN
cord-259748-x7dq1sy4	165	1	(	(	-LRB-
cord-259748-x7dq1sy4	165	2	LC3	LC3	NNP
cord-259748-x7dq1sy4	165	3	)	)	-RRB-
cord-259748-x7dq1sy4	165	4	undergoing	undergo	VBG
cord-259748-x7dq1sy4	165	5	lipidation	lipidation	NN
cord-259748-x7dq1sy4	165	6	,	,	,
cord-259748-x7dq1sy4	165	7	thereby	thereby	RB
cord-259748-x7dq1sy4	165	8	resulting	result	VBG
cord-259748-x7dq1sy4	165	9	in	in	IN
cord-259748-x7dq1sy4	165	10	elongation	elongation	NN
cord-259748-x7dq1sy4	165	11	of	of	IN
cord-259748-x7dq1sy4	165	12	the	the	DT
cord-259748-x7dq1sy4	165	13	autophagosome	autophagosome	NN
cord-259748-x7dq1sy4	165	14	(	(	-LRB-
cord-259748-x7dq1sy4	165	15	88	88	CD
cord-259748-x7dq1sy4	165	16	)	)	-RRB-
cord-259748-x7dq1sy4	165	17	.	.	.
cord-259748-x7dq1sy4	166	1	LC3	LC3	NNP
cord-259748-x7dq1sy4	166	2	can	can	MD
cord-259748-x7dq1sy4	166	3	also	also	RB
cord-259748-x7dq1sy4	166	4	be	be	VB
cord-259748-x7dq1sy4	166	5	recruited	recruit	VBN
cord-259748-x7dq1sy4	166	6	directly	directly	RB
cord-259748-x7dq1sy4	166	7	by	by	IN
cord-259748-x7dq1sy4	166	8	ERGIC	ergic	NN
cord-259748-x7dq1sy4	166	9	-	-	HYPH
cord-259748-x7dq1sy4	166	10	loading	load	VBG
cord-259748-x7dq1sy4	166	11	STING	sting	NN
cord-259748-x7dq1sy4	166	12	and	and	CC
cord-259748-x7dq1sy4	166	13	bypass	bypass	VB
cord-259748-x7dq1sy4	166	14	the	the	DT
cord-259748-x7dq1sy4	166	15	classical	classical	JJ
cord-259748-x7dq1sy4	166	16	autophagy	autophagy	NN
cord-259748-x7dq1sy4	166	17	pathway	pathway	NN
cord-259748-x7dq1sy4	166	18	(	(	-LRB-
cord-259748-x7dq1sy4	166	19	68	68	CD
cord-259748-x7dq1sy4	166	20	,	,	,
cord-259748-x7dq1sy4	166	21	89	89	CD
cord-259748-x7dq1sy4	166	22	)	)	-RRB-
cord-259748-x7dq1sy4	166	23	.	.	.
cord-259748-x7dq1sy4	167	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	167	2	-	-	HYPH
cord-259748-x7dq1sy4	167	3	STING	sting	NN
cord-259748-x7dq1sy4	167	4	-	-	HYPH
cord-259748-x7dq1sy4	167	5	mediated	mediate	VBN
cord-259748-x7dq1sy4	167	6	autophagy	autophagy	NN
cord-259748-x7dq1sy4	167	7	can	can	MD
cord-259748-x7dq1sy4	167	8	spread	spread	VB
cord-259748-x7dq1sy4	167	9	to	to	IN
cord-259748-x7dq1sy4	167	10	the	the	DT
cord-259748-x7dq1sy4	167	11	whole	whole	JJ
cord-259748-x7dq1sy4	167	12	cell	cell	NN
cord-259748-x7dq1sy4	167	13	and	and	CC
cord-259748-x7dq1sy4	167	14	help	help	VB
cord-259748-x7dq1sy4	167	15	the	the	DT
cord-259748-x7dq1sy4	167	16	elimination	elimination	NN
cord-259748-x7dq1sy4	167	17	of	of	IN
cord-259748-x7dq1sy4	167	18	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	167	19	microorganisms	microorganism	NNS
cord-259748-x7dq1sy4	167	20	,	,	,
cord-259748-x7dq1sy4	167	21	subcellular	subcellular	JJ
cord-259748-x7dq1sy4	167	22	organelles	organelle	NNS
cord-259748-x7dq1sy4	167	23	or	or	CC
cord-259748-x7dq1sy4	167	24	misfolded	misfolde	VBN
cord-259748-x7dq1sy4	167	25	proteins	protein	NNS
cord-259748-x7dq1sy4	167	26	,	,	,
cord-259748-x7dq1sy4	167	27	as	as	RB
cord-259748-x7dq1sy4	167	28	well	well	RB
cord-259748-x7dq1sy4	167	29	as	as	IN
cord-259748-x7dq1sy4	167	30	the	the	DT
cord-259748-x7dq1sy4	167	31	ER	ER	NNP
cord-259748-x7dq1sy4	167	32	itself	-PRON-	PRP
cord-259748-x7dq1sy4	167	33	that	that	WDT
cord-259748-x7dq1sy4	167	34	loads	load	VBZ
cord-259748-x7dq1sy4	167	35	the	the	DT
cord-259748-x7dq1sy4	167	36	STING	sting	NN
cord-259748-x7dq1sy4	167	37	signalosome	signalosome	NN
cord-259748-x7dq1sy4	167	38	(	(	-LRB-
cord-259748-x7dq1sy4	167	39	90	90	CD
cord-259748-x7dq1sy4	167	40	-	-	SYM
cord-259748-x7dq1sy4	167	41	92	92	CD
cord-259748-x7dq1sy4	167	42	)	)	-RRB-
cord-259748-x7dq1sy4	168	1	(	(	-LRB-
cord-259748-x7dq1sy4	168	2	Figure	Figure	NNP
cord-259748-x7dq1sy4	168	3	2D	2d	NN
cord-259748-x7dq1sy4	168	4	)	)	-RRB-
cord-259748-x7dq1sy4	168	5	.	.	.
cord-259748-x7dq1sy4	169	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	169	2	-	-	HYPH
cord-259748-x7dq1sy4	169	3	STING	sting	NN
cord-259748-x7dq1sy4	169	4	-	-	HYPH
cord-259748-x7dq1sy4	169	5	mediated	mediate	VBN
cord-259748-x7dq1sy4	169	6	autophagy	autophagy	NN
cord-259748-x7dq1sy4	169	7	is	be	VBZ
cord-259748-x7dq1sy4	169	8	also	also	RB
cord-259748-x7dq1sy4	169	9	indispensable	indispensable	JJ
cord-259748-x7dq1sy4	169	10	for	for	IN
cord-259748-x7dq1sy4	169	11	removing	remove	VBG
cord-259748-x7dq1sy4	169	12	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	169	13	DNA	dna	NN
cord-259748-x7dq1sy4	169	14	and	and	CC
cord-259748-x7dq1sy4	169	15	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	169	16	signaling	signaling	NN
cord-259748-x7dq1sy4	169	17	factors	factor	NNS
cord-259748-x7dq1sy4	169	18	to	to	TO
cord-259748-x7dq1sy4	169	19	restrict	restrict	VB
cord-259748-x7dq1sy4	169	20	the	the	DT
cord-259748-x7dq1sy4	169	21	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	169	22	response	response	NN
cord-259748-x7dq1sy4	169	23	raised	raise	VBN
cord-259748-x7dq1sy4	169	24	by	by	IN
cord-259748-x7dq1sy4	169	25	the	the	DT
cord-259748-x7dq1sy4	169	26	pathway	pathway	NN
cord-259748-x7dq1sy4	169	27	itself	-PRON-	PRP
cord-259748-x7dq1sy4	169	28	(	(	-LRB-
cord-259748-x7dq1sy4	169	29	93	93	CD
cord-259748-x7dq1sy4	169	30	)	)	-RRB-
cord-259748-x7dq1sy4	169	31	.	.	.
cord-259748-x7dq1sy4	170	1	Excessive	excessive	JJ
cord-259748-x7dq1sy4	170	2	signaling	signaling	NN
cord-259748-x7dq1sy4	170	3	of	of	IN
cord-259748-x7dq1sy4	170	4	the	the	DT
cord-259748-x7dq1sy4	170	5	autophagy	autophagy	NN
cord-259748-x7dq1sy4	170	6	cascade	cascade	NN
cord-259748-x7dq1sy4	170	7	can	can	MD
cord-259748-x7dq1sy4	170	8	lead	lead	VB
cord-259748-x7dq1sy4	170	9	to	to	IN
cord-259748-x7dq1sy4	170	10	irreversible	irreversible	JJ
cord-259748-x7dq1sy4	170	11	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	170	12	termed	term	VBN
cord-259748-x7dq1sy4	170	13	"	"	``
cord-259748-x7dq1sy4	170	14	autophagic	autophagic	JJ
cord-259748-x7dq1sy4	170	15	cell	cell	NN
cord-259748-x7dq1sy4	170	16	death	death	NN
cord-259748-x7dq1sy4	170	17	"	"	''
cord-259748-x7dq1sy4	170	18	(	(	-LRB-
cord-259748-x7dq1sy4	170	19	94	94	CD
cord-259748-x7dq1sy4	170	20	)	)	-RRB-
cord-259748-x7dq1sy4	170	21	.	.	.
cord-259748-x7dq1sy4	171	1	Consequently	consequently	RB
cord-259748-x7dq1sy4	171	2	,	,	,
cord-259748-x7dq1sy4	171	3	oligomerized	oligomerize	VBN
cord-259748-x7dq1sy4	171	4	cGAS	cgas	NN
cord-259748-x7dq1sy4	171	5	or	or	CC
cord-259748-x7dq1sy4	171	6	STING	sting	NN
cord-259748-x7dq1sy4	171	7	undergoes	undergo	VBZ
cord-259748-x7dq1sy4	171	8	ubiquitination	ubiquitination	NN
cord-259748-x7dq1sy4	171	9	and	and	CC
cord-259748-x7dq1sy4	171	10	is	be	VBZ
cord-259748-x7dq1sy4	171	11	packaged	package	VBN
cord-259748-x7dq1sy4	171	12	into	into	IN
cord-259748-x7dq1sy4	171	13	autophagosomes	autophagosome	NNS
cord-259748-x7dq1sy4	171	14	with	with	IN
cord-259748-x7dq1sy4	171	15	the	the	DT
cord-259748-x7dq1sy4	171	16	help	help	NN
cord-259748-x7dq1sy4	171	17	of	of	IN
cord-259748-x7dq1sy4	171	18	p62	p62	NN
cord-259748-x7dq1sy4	171	19	,	,	,
cord-259748-x7dq1sy4	171	20	to	to	TO
cord-259748-x7dq1sy4	171	21	be	be	VB
cord-259748-x7dq1sy4	171	22	terminally	terminally	RB
cord-259748-x7dq1sy4	171	23	sorted	sort	VBN
cord-259748-x7dq1sy4	171	24	into	into	IN
cord-259748-x7dq1sy4	171	25	lysosomes	lysosome	NNS
cord-259748-x7dq1sy4	171	26	(	(	-LRB-
cord-259748-x7dq1sy4	171	27	79	79	CD
cord-259748-x7dq1sy4	171	28	,	,	,
cord-259748-x7dq1sy4	171	29	83	83	CD
cord-259748-x7dq1sy4	171	30	,	,	,
cord-259748-x7dq1sy4	171	31	95	95	CD
cord-259748-x7dq1sy4	171	32	,	,	,
cord-259748-x7dq1sy4	171	33	96	96	CD
cord-259748-x7dq1sy4	171	34	)	)	-RRB-
cord-259748-x7dq1sy4	171	35	.	.	.
cord-259748-x7dq1sy4	172	1	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	173	1	or	or	CC
cord-259748-x7dq1sy4	173	2	STING	STING	NNP
cord-259748-x7dq1sy4	173	3	is	be	VBZ
cord-259748-x7dq1sy4	173	4	digested	digest	VBN
cord-259748-x7dq1sy4	173	5	immediately	immediately	RB
cord-259748-x7dq1sy4	173	6	in	in	IN
cord-259748-x7dq1sy4	173	7	the	the	DT
cord-259748-x7dq1sy4	173	8	autophagolysosome	autophagolysosome	NN
cord-259748-x7dq1sy4	173	9	after	after	IN
cord-259748-x7dq1sy4	173	10	transient	transient	JJ
cord-259748-x7dq1sy4	173	11	activation	activation	NN
cord-259748-x7dq1sy4	173	12	of	of	IN
cord-259748-x7dq1sy4	173	13	downstream	downstream	JJ
cord-259748-x7dq1sy4	173	14	signaling	signaling	NN
cord-259748-x7dq1sy4	173	15	(	(	-LRB-
cord-259748-x7dq1sy4	173	16	68	68	CD
cord-259748-x7dq1sy4	173	17	,	,	,
cord-259748-x7dq1sy4	173	18	79	79	CD
cord-259748-x7dq1sy4	173	19	,	,	,
cord-259748-x7dq1sy4	173	20	83	83	CD
cord-259748-x7dq1sy4	173	21	,	,	,
cord-259748-x7dq1sy4	173	22	89	89	CD
cord-259748-x7dq1sy4	173	23	)	)	-RRB-
cord-259748-x7dq1sy4	173	24	.	.	.
cord-259748-x7dq1sy4	174	1	Autophagy	Autophagy	NNP
cord-259748-x7dq1sy4	174	2	functions	function	NNS
cord-259748-x7dq1sy4	174	3	as	as	IN
cord-259748-x7dq1sy4	174	4	a	a	DT
cord-259748-x7dq1sy4	174	5	negative	negative	JJ
cord-259748-x7dq1sy4	174	6	feedback	feedback	NN
cord-259748-x7dq1sy4	174	7	loop	loop	NN
cord-259748-x7dq1sy4	174	8	which	which	WDT
cord-259748-x7dq1sy4	174	9	ensures	ensure	VBZ
cord-259748-x7dq1sy4	174	10	transient	transient	JJ
cord-259748-x7dq1sy4	174	11	cGAS	cgas	NN
cord-259748-x7dq1sy4	174	12	-	-	HYPH
cord-259748-x7dq1sy4	174	13	STING	sting	NN
cord-259748-x7dq1sy4	174	14	signaling	signaling	NN
cord-259748-x7dq1sy4	174	15	and	and	CC
cord-259748-x7dq1sy4	174	16	avoids	avoid	VBZ
cord-259748-x7dq1sy4	174	17	consistent	consistent	JJ
cord-259748-x7dq1sy4	174	18	over	over	IN
cord-259748-x7dq1sy4	174	19	-	-	HYPH
cord-259748-x7dq1sy4	174	20	reaction	reaction	NN
cord-259748-x7dq1sy4	174	21	of	of	IN
cord-259748-x7dq1sy4	174	22	the	the	DT
cord-259748-x7dq1sy4	174	23	pathway	pathway	NN
cord-259748-x7dq1sy4	174	24	.	.	.
cord-259748-x7dq1sy4	175	1	Thus	thus	RB
cord-259748-x7dq1sy4	175	2	,	,	,
cord-259748-x7dq1sy4	175	3	impairment	impairment	NN
cord-259748-x7dq1sy4	175	4	of	of	IN
cord-259748-x7dq1sy4	175	5	autophagy	autophagy	NN
cord-259748-x7dq1sy4	175	6	may	may	MD
cord-259748-x7dq1sy4	175	7	give	give	VB
cord-259748-x7dq1sy4	175	8	rise	rise	NN
cord-259748-x7dq1sy4	175	9	to	to	IN
cord-259748-x7dq1sy4	175	10	destructive	destructive	JJ
cord-259748-x7dq1sy4	175	11	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	175	12	diseases	disease	NNS
cord-259748-x7dq1sy4	175	13	(	(	-LRB-
cord-259748-x7dq1sy4	175	14	31	31	CD
cord-259748-x7dq1sy4	175	15	)	)	-RRB-
cord-259748-x7dq1sy4	175	16	.	.	.
cord-259748-x7dq1sy4	176	1	We	-PRON-	PRP
cord-259748-x7dq1sy4	176	2	cataloged	catalog	VBD
cord-259748-x7dq1sy4	176	3	factors	factor	NNS
cord-259748-x7dq1sy4	176	4	in	in	IN
cord-259748-x7dq1sy4	176	5	the	the	DT
cord-259748-x7dq1sy4	176	6	literature	literature	NN
cord-259748-x7dq1sy4	176	7	that	that	WDT
cord-259748-x7dq1sy4	176	8	could	could	MD
cord-259748-x7dq1sy4	176	9	potentially	potentially	RB
cord-259748-x7dq1sy4	176	10	up	up	RB
cord-259748-x7dq1sy4	176	11	-	-	HYPH
cord-259748-x7dq1sy4	176	12	or	or	CC
cord-259748-x7dq1sy4	176	13	down	down	RB
cord-259748-x7dq1sy4	176	14	-	-	HYPH
cord-259748-x7dq1sy4	176	15	regulate	regulate	VB
cord-259748-x7dq1sy4	176	16	expression	expression	NN
cord-259748-x7dq1sy4	176	17	of	of	IN
cord-259748-x7dq1sy4	176	18	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	176	19	/	/	SYM
cord-259748-x7dq1sy4	176	20	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	176	21	/	/	SYM
cord-259748-x7dq1sy4	176	22	STING	sting	VB
cord-259748-x7dq1sy4	176	23	in	in	IN
cord-259748-x7dq1sy4	176	24	pre	pre	JJ
cord-259748-x7dq1sy4	176	25	-	-	JJ
cord-259748-x7dq1sy4	176	26	translational	translational	JJ
cord-259748-x7dq1sy4	176	27	or	or	CC
cord-259748-x7dq1sy4	176	28	post	post	JJ
cord-259748-x7dq1sy4	176	29	-	-	JJ
cord-259748-x7dq1sy4	176	30	translational	translational	JJ
cord-259748-x7dq1sy4	176	31	stages	stage	NNS
cord-259748-x7dq1sy4	176	32	(	(	-LRB-
cord-259748-x7dq1sy4	176	33	Tables	table	NNS
cord-259748-x7dq1sy4	176	34	1	1	CD
cord-259748-x7dq1sy4	176	35	,	,	,
cord-259748-x7dq1sy4	176	36	2	2	CD
cord-259748-x7dq1sy4	176	37	)	)	-RRB-
cord-259748-x7dq1sy4	176	38	.	.	.
cord-259748-x7dq1sy4	177	1	The	the	DT
cord-259748-x7dq1sy4	177	2	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	177	3	mechanisms	mechanism	NNS
cord-259748-x7dq1sy4	177	4	of	of	IN
cord-259748-x7dq1sy4	177	5	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	177	6	,	,	,
cord-259748-x7dq1sy4	177	7	IRF	IRF	NNP
cord-259748-x7dq1sy4	177	8	,	,	,
cord-259748-x7dq1sy4	177	9	and	and	CC
cord-259748-x7dq1sy4	177	10	NF	nf	NN
cord-259748-x7dq1sy4	177	11	-	-	HYPH
cord-259748-x7dq1sy4	177	12	κB	κB	NNP
cord-259748-x7dq1sy4	177	13	in	in	IN
cord-259748-x7dq1sy4	177	14	signaling	signal	VBG
cord-259748-x7dq1sy4	177	15	pathways	pathway	NNS
cord-259748-x7dq1sy4	177	16	associated	associate	VBN
cord-259748-x7dq1sy4	177	17	with	with	IN
cord-259748-x7dq1sy4	177	18	expression	expression	NN
cord-259748-x7dq1sy4	177	19	of	of	IN
cord-259748-x7dq1sy4	177	20	type	type	NN
cord-259748-x7dq1sy4	177	21	-	-	:
cord-259748-x7dq1sy4	177	22	I	-PRON-	PRP
cord-259748-x7dq1sy4	177	23	IFN	IFN	NNP
cord-259748-x7dq1sy4	177	24	are	be	VBP
cord-259748-x7dq1sy4	177	25	outside	outside	IN
cord-259748-x7dq1sy4	177	26	the	the	DT
cord-259748-x7dq1sy4	177	27	scope	scope	NN
cord-259748-x7dq1sy4	177	28	of	of	IN
cord-259748-x7dq1sy4	177	29	this	this	DT
cord-259748-x7dq1sy4	177	30	review	review	NN
cord-259748-x7dq1sy4	177	31	.	.	.
cord-259748-x7dq1sy4	178	1	PYHIN	PYHIN	NNP
cord-259748-x7dq1sy4	178	2	family	family	NN
cord-259748-x7dq1sy4	178	3	member	member	NN
cord-259748-x7dq1sy4	178	4	absent	absent	JJ
cord-259748-x7dq1sy4	178	5	in	in	IN
cord-259748-x7dq1sy4	178	6	melanoma	melanoma	NN
cord-259748-x7dq1sy4	178	7	2	2	CD
cord-259748-x7dq1sy4	178	8	(	(	-LRB-
cord-259748-x7dq1sy4	178	9	AIM2	AIM2	NNP
cord-259748-x7dq1sy4	178	10	)	)	-RRB-
cord-259748-x7dq1sy4	178	11	is	be	VBZ
cord-259748-x7dq1sy4	178	12	a	a	DT
cord-259748-x7dq1sy4	178	13	cytoplasmic	cytoplasmic	JJ
cord-259748-x7dq1sy4	178	14	dsDNA	dsdna	JJ
cord-259748-x7dq1sy4	178	15	sensor	sensor	NN
cord-259748-x7dq1sy4	178	16	.	.	.
cord-259748-x7dq1sy4	179	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	179	2	can	can	MD
cord-259748-x7dq1sy4	179	3	recruit	recruit	VB
cord-259748-x7dq1sy4	179	4	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	179	5	-	-	HYPH
cord-259748-x7dq1sy4	179	6	associated	associate	VBN
cord-259748-x7dq1sy4	179	7	speck	speck	NN
cord-259748-x7dq1sy4	179	8	-	-	HYPH
cord-259748-x7dq1sy4	179	9	like	like	JJ
cord-259748-x7dq1sy4	179	10	protein	protein	NN
cord-259748-x7dq1sy4	179	11	containing	contain	VBG
cord-259748-x7dq1sy4	179	12	a	a	DT
cord-259748-x7dq1sy4	179	13	CARD	card	NN
cord-259748-x7dq1sy4	179	14	(	(	-LRB-
cord-259748-x7dq1sy4	179	15	ASC	ASC	NNP
cord-259748-x7dq1sy4	179	16	)	)	-RRB-
cord-259748-x7dq1sy4	179	17	by	by	IN
cord-259748-x7dq1sy4	179	18	its	-PRON-	PRP$
cord-259748-x7dq1sy4	179	19	PYHIN	PYHIN	NNP
cord-259748-x7dq1sy4	179	20	domain	domain	NN
cord-259748-x7dq1sy4	179	21	and	and	CC
cord-259748-x7dq1sy4	179	22	form	form	VB
cord-259748-x7dq1sy4	179	23	the	the	DT
cord-259748-x7dq1sy4	179	24	AIM2	AIM2	NNP
cord-259748-x7dq1sy4	179	25	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	179	26	.	.	.
cord-259748-x7dq1sy4	180	1	The	the	DT
cord-259748-x7dq1sy4	180	2	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	180	3	activates	activate	VBZ
cord-259748-x7dq1sy4	180	4	caspase-1	caspase-1	NNP
cord-259748-x7dq1sy4	180	5	,	,	,
cord-259748-x7dq1sy4	180	6	which	which	WDT
cord-259748-x7dq1sy4	180	7	activates	activate	VBZ
cord-259748-x7dq1sy4	180	8	IL-1	IL-1	NNP
cord-259748-x7dq1sy4	180	9	and	and	CC
cord-259748-x7dq1sy4	180	10	trigger	trigger	NN
cord-259748-x7dq1sy4	180	11	pyroptosis	pyroptosis	NNP
cord-259748-x7dq1sy4	180	12	(	(	-LRB-
cord-259748-x7dq1sy4	180	13	97	97	CD
cord-259748-x7dq1sy4	180	14	)	)	-RRB-
cord-259748-x7dq1sy4	180	15	.	.	.
cord-259748-x7dq1sy4	181	1	The	the	DT
cord-259748-x7dq1sy4	181	2	AIM2	AIM2	NNP
cord-259748-x7dq1sy4	181	3	pathway	pathway	NN
cord-259748-x7dq1sy4	181	4	could	could	MD
cord-259748-x7dq1sy4	181	5	counteract	counteract	VB
cord-259748-x7dq1sy4	181	6	the	the	DT
cord-259748-x7dq1sy4	181	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	181	8	-	-	HYPH
cord-259748-x7dq1sy4	181	9	STING	sting	NN
cord-259748-x7dq1sy4	181	10	pathway	pathway	NN
cord-259748-x7dq1sy4	181	11	(	(	-LRB-
cord-259748-x7dq1sy4	181	12	98	98	CD
cord-259748-x7dq1sy4	181	13	)	)	-RRB-
cord-259748-x7dq1sy4	181	14	.	.	.
cord-259748-x7dq1sy4	182	1	First	first	RB
cord-259748-x7dq1sy4	182	2	,	,	,
cord-259748-x7dq1sy4	182	3	cGAS	cgas	NN
cord-259748-x7dq1sy4	182	4	is	be	VBZ
cord-259748-x7dq1sy4	182	5	a	a	DT
cord-259748-x7dq1sy4	182	6	target	target	NN
cord-259748-x7dq1sy4	182	7	for	for	IN
cord-259748-x7dq1sy4	182	8	caspase-1	caspase-1	NNP
cord-259748-x7dq1sy4	182	9	cleavage	cleavage	NN
cord-259748-x7dq1sy4	182	10	(	(	-LRB-
cord-259748-x7dq1sy4	182	11	99	99	CD
cord-259748-x7dq1sy4	182	12	)	)	-RRB-
cord-259748-x7dq1sy4	182	13	.	.	.
cord-259748-x7dq1sy4	183	1	Second	second	RB
cord-259748-x7dq1sy4	183	2	,	,	,
cord-259748-x7dq1sy4	183	3	gasdermin	gasdermin	NNP
cord-259748-x7dq1sy4	183	4	D	d	NN
cord-259748-x7dq1sy4	183	5	activated	activate	VBN
cord-259748-x7dq1sy4	183	6	by	by	IN
cord-259748-x7dq1sy4	183	7	caspase-1	caspase-1	NNP
cord-259748-x7dq1sy4	183	8	can	can	MD
cord-259748-x7dq1sy4	183	9	lead	lead	VB
cord-259748-x7dq1sy4	183	10	to	to	IN
cord-259748-x7dq1sy4	183	11	potassium	potassium	NN
cord-259748-x7dq1sy4	183	12	ion	ion	NN
cord-259748-x7dq1sy4	183	13	(	(	-LRB-
cord-259748-x7dq1sy4	183	14	K	k	NN
cord-259748-x7dq1sy4	183	15	+	+	CC
cord-259748-x7dq1sy4	183	16	)	)	-RRB-
cord-259748-x7dq1sy4	183	17	efflux	efflux	NN
cord-259748-x7dq1sy4	183	18	which	which	WDT
cord-259748-x7dq1sy4	183	19	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	183	20	cGAS	cgas	JJ
cord-259748-x7dq1sy4	183	21	(	(	-LRB-
cord-259748-x7dq1sy4	183	22	100	100	CD
cord-259748-x7dq1sy4	183	23	)	)	-RRB-
cord-259748-x7dq1sy4	183	24	.	.	.
cord-259748-x7dq1sy4	184	1	Conversely	conversely	RB
cord-259748-x7dq1sy4	184	2	,	,	,
cord-259748-x7dq1sy4	184	3	the	the	DT
cord-259748-x7dq1sy4	184	4	cGAS	cgas	JJ
cord-259748-x7dq1sy4	184	5	-	-	HYPH
cord-259748-x7dq1sy4	184	6	STING	sting	NN
cord-259748-x7dq1sy4	184	7	pathway	pathway	NN
cord-259748-x7dq1sy4	184	8	can	can	MD
cord-259748-x7dq1sy4	184	9	trigger	trigger	VB
cord-259748-x7dq1sy4	184	10	the	the	DT
cord-259748-x7dq1sy4	184	11	AIM2	AIM2	NNP
cord-259748-x7dq1sy4	184	12	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	184	13	or	or	CC
cord-259748-x7dq1sy4	184	14	NLR	NLR	NNP
cord-259748-x7dq1sy4	184	15	family	family	NN
cord-259748-x7dq1sy4	184	16	pyrin	pyrin	NNP
cord-259748-x7dq1sy4	184	17	domain	domain	NN
cord-259748-x7dq1sy4	184	18	containing	contain	VBG
cord-259748-x7dq1sy4	184	19	3	3	CD
cord-259748-x7dq1sy4	184	20	(	(	-LRB-
cord-259748-x7dq1sy4	184	21	NLRP3	nlrp3	NN
cord-259748-x7dq1sy4	184	22	)	)	-RRB-
cord-259748-x7dq1sy4	184	23	by	by	IN
cord-259748-x7dq1sy4	184	24	several	several	JJ
cord-259748-x7dq1sy4	184	25	means	mean	NNS
cord-259748-x7dq1sy4	184	26	,	,	,
cord-259748-x7dq1sy4	184	27	and	and	CC
cord-259748-x7dq1sy4	184	28	the	the	DT
cord-259748-x7dq1sy4	184	29	process	process	NN
cord-259748-x7dq1sy4	184	30	lags	lag	VBZ
cord-259748-x7dq1sy4	184	31	behind	behind	IN
cord-259748-x7dq1sy4	184	32	canonical	canonical	JJ
cord-259748-x7dq1sy4	184	33	IFN	IFN	NNP
cord-259748-x7dq1sy4	184	34	signaling	signal	VBG
cord-259748-x7dq1sy4	184	35	(	(	-LRB-
cord-259748-x7dq1sy4	184	36	96	96	CD
cord-259748-x7dq1sy4	184	37	,	,	,
cord-259748-x7dq1sy4	184	38	101	101	CD
cord-259748-x7dq1sy4	184	39	)	)	-RRB-
cord-259748-x7dq1sy4	184	40	.	.	.
cord-259748-x7dq1sy4	185	1	In	in	IN
cord-259748-x7dq1sy4	185	2	this	this	DT
cord-259748-x7dq1sy4	185	3	way	way	NN
cord-259748-x7dq1sy4	185	4	,	,	,
cord-259748-x7dq1sy4	185	5	the	the	DT
cord-259748-x7dq1sy4	185	6	inhibitory	inhibitory	JJ
cord-259748-x7dq1sy4	185	7	nucleic	nucleic	JJ
cord-259748-x7dq1sy4	185	8	-	-	HYPH
cord-259748-x7dq1sy4	185	9	acid	acid	NN
cord-259748-x7dq1sy4	185	10	sensor	sensor	NN
cord-259748-x7dq1sy4	185	11	NLR	NLR	NNP
cord-259748-x7dq1sy4	185	12	family	family	NN
cord-259748-x7dq1sy4	185	13	CARD	card	NN
cord-259748-x7dq1sy4	185	14	domain	domain	NN
cord-259748-x7dq1sy4	185	15	containing	contain	VBG
cord-259748-x7dq1sy4	185	16	3	3	CD
cord-259748-x7dq1sy4	185	17	(	(	-LRB-
cord-259748-x7dq1sy4	185	18	NLRC3	NLRC3	NNP
cord-259748-x7dq1sy4	185	19	)	)	-RRB-
cord-259748-x7dq1sy4	185	20	can	can	MD
cord-259748-x7dq1sy4	185	21	counteract	counteract	VB
cord-259748-x7dq1sy4	185	22	STING	sting	NN
cord-259748-x7dq1sy4	185	23	by	by	IN
cord-259748-x7dq1sy4	185	24	binding	bind	VBG
cord-259748-x7dq1sy4	185	25	and	and	CC
cord-259748-x7dq1sy4	185	26	occupying	occupy	VBG
cord-259748-x7dq1sy4	185	27	it	-PRON-	PRP
cord-259748-x7dq1sy4	185	28	,	,	,
cord-259748-x7dq1sy4	185	29	but	but	CC
cord-259748-x7dq1sy4	185	30	viral	viral	JJ
cord-259748-x7dq1sy4	185	31	DNA	dna	NN
cord-259748-x7dq1sy4	185	32	as	as	IN
cord-259748-x7dq1sy4	185	33	a	a	DT
cord-259748-x7dq1sy4	185	34	possible	possible	JJ
cord-259748-x7dq1sy4	185	35	NLRC3	nlrc3	JJ
cord-259748-x7dq1sy4	185	36	ligand	ligand	NN
cord-259748-x7dq1sy4	185	37	can	can	MD
cord-259748-x7dq1sy4	185	38	reverse	reverse	VB
cord-259748-x7dq1sy4	185	39	its	-PRON-	PRP$
cord-259748-x7dq1sy4	185	40	occupation	occupation	NN
cord-259748-x7dq1sy4	185	41	of	of	IN
cord-259748-x7dq1sy4	185	42	STING	STING	NNP
cord-259748-x7dq1sy4	185	43	(	(	-LRB-
cord-259748-x7dq1sy4	185	44	102	102	CD
cord-259748-x7dq1sy4	185	45	)	)	-RRB-
cord-259748-x7dq1sy4	185	46	(	(	-LRB-
cord-259748-x7dq1sy4	185	47	Figure	figure	NN
cord-259748-x7dq1sy4	185	48	3A	3a	CD
cord-259748-x7dq1sy4	185	49	)	)	-RRB-
cord-259748-x7dq1sy4	185	50	.	.	.
cord-259748-x7dq1sy4	186	1	Another	another	DT
cord-259748-x7dq1sy4	186	2	PYHIN	PYHIN	NNP
cord-259748-x7dq1sy4	186	3	family	family	NN
cord-259748-x7dq1sy4	186	4	member	member	NN
cord-259748-x7dq1sy4	186	5	,	,	,
cord-259748-x7dq1sy4	186	6	IFI16	IFI16	NNP
cord-259748-x7dq1sy4	186	7	,	,	,
cord-259748-x7dq1sy4	186	8	is	be	VBZ
cord-259748-x7dq1sy4	186	9	a	a	DT
cord-259748-x7dq1sy4	186	10	DNA	dna	NN
cord-259748-x7dq1sy4	186	11	sensor	sensor	NN
cord-259748-x7dq1sy4	186	12	located	locate	VBN
cord-259748-x7dq1sy4	186	13	in	in	IN
cord-259748-x7dq1sy4	186	14	the	the	DT
cord-259748-x7dq1sy4	186	15	nucleus	nucleus	NN
cord-259748-x7dq1sy4	186	16	.	.	.
cord-259748-x7dq1sy4	187	1	IFI16	IFI16	NNP
cord-259748-x7dq1sy4	187	2	can	can	MD
cord-259748-x7dq1sy4	187	3	bind	bind	VB
cord-259748-x7dq1sy4	187	4	to	to	IN
cord-259748-x7dq1sy4	187	5	viral	viral	JJ
cord-259748-x7dq1sy4	187	6	DNA	dna	NN
cord-259748-x7dq1sy4	187	7	sequences	sequence	NNS
cord-259748-x7dq1sy4	187	8	or	or	CC
cord-259748-x7dq1sy4	187	9	damaged	damage	VBN
cord-259748-x7dq1sy4	187	10	chromatin	chromatin	NN
cord-259748-x7dq1sy4	187	11	DNA	dna	NN
cord-259748-x7dq1sy4	187	12	and	and	CC
cord-259748-x7dq1sy4	187	13	be	be	VB
cord-259748-x7dq1sy4	187	14	translocated	translocate	VBN
cord-259748-x7dq1sy4	187	15	to	to	IN
cord-259748-x7dq1sy4	187	16	the	the	DT
cord-259748-x7dq1sy4	187	17	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	187	18	to	to	TO
cord-259748-x7dq1sy4	187	19	recruit	recruit	VB
cord-259748-x7dq1sy4	187	20	STING	sting	NN
cord-259748-x7dq1sy4	187	21	cooperatively	cooperatively	RB
cord-259748-x7dq1sy4	187	22	with	with	IN
cord-259748-x7dq1sy4	187	23	TNF	TNF	NNP
cord-259748-x7dq1sy4	187	24	receptor	receptor	NN
cord-259748-x7dq1sy4	187	25	associated	associate	VBD
cord-259748-x7dq1sy4	187	26	factor	factor	NN
cord-259748-x7dq1sy4	187	27	6	6	CD
cord-259748-x7dq1sy4	187	28	(	(	-LRB-
cord-259748-x7dq1sy4	187	29	TRAF6	TRAF6	NNP
cord-259748-x7dq1sy4	187	30	)	)	-RRB-
cord-259748-x7dq1sy4	187	31	and	and	CC
cord-259748-x7dq1sy4	187	32	p53	p53	NN
cord-259748-x7dq1sy4	187	33	(	(	-LRB-
cord-259748-x7dq1sy4	187	34	103	103	CD
cord-259748-x7dq1sy4	187	35	,	,	,
cord-259748-x7dq1sy4	187	36	104	104	CD
cord-259748-x7dq1sy4	187	37	)	)	-RRB-
cord-259748-x7dq1sy4	187	38	.	.	.
cord-259748-x7dq1sy4	188	1	Several	several	JJ
cord-259748-x7dq1sy4	188	2	studies	study	NNS
cord-259748-x7dq1sy4	188	3	have	have	VBP
cord-259748-x7dq1sy4	188	4	shown	show	VBN
cord-259748-x7dq1sy4	188	5	that	that	IN
cord-259748-x7dq1sy4	188	6	IFI16	ifi16	NN
cord-259748-x7dq1sy4	188	7	(	(	-LRB-
cord-259748-x7dq1sy4	188	8	which	which	WDT
cord-259748-x7dq1sy4	188	9	can	can	MD
cord-259748-x7dq1sy4	188	10	stimulate	stimulate	VB
cord-259748-x7dq1sy4	188	11	the	the	DT
cord-259748-x7dq1sy4	188	12	phosphorylation	phosphorylation	NN
cord-259748-x7dq1sy4	188	13	and	and	CC
cord-259748-x7dq1sy4	188	14	recruitment	recruitment	NN
cord-259748-x7dq1sy4	188	15	of	of	IN
cord-259748-x7dq1sy4	188	16	STING	STING	NNP
cord-259748-x7dq1sy4	188	17	and	and	CC
cord-259748-x7dq1sy4	188	18	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	188	19	)	)	-RRB-
cord-259748-x7dq1sy4	188	20	is	be	VBZ
cord-259748-x7dq1sy4	188	21	required	require	VBN
cord-259748-x7dq1sy4	188	22	for	for	IN
cord-259748-x7dq1sy4	188	23	the	the	DT
cord-259748-x7dq1sy4	188	24	full	full	JJ
cord-259748-x7dq1sy4	188	25	response	response	NN
cord-259748-x7dq1sy4	188	26	of	of	IN
cord-259748-x7dq1sy4	188	27	STING	STING	NNP
cord-259748-x7dq1sy4	188	28	(	(	-LRB-
cord-259748-x7dq1sy4	188	29	105	105	CD
cord-259748-x7dq1sy4	188	30	,	,	,
cord-259748-x7dq1sy4	188	31	106	106	CD
cord-259748-x7dq1sy4	188	32	)	)	-RRB-
cord-259748-x7dq1sy4	188	33	(	(	-LRB-
cord-259748-x7dq1sy4	188	34	Figure	figure	NN
cord-259748-x7dq1sy4	188	35	3B	3b	CD
cord-259748-x7dq1sy4	188	36	)	)	-RRB-
cord-259748-x7dq1sy4	188	37	.	.	.
cord-259748-x7dq1sy4	189	1	Conversely	conversely	RB
cord-259748-x7dq1sy4	189	2	,	,	,
cord-259748-x7dq1sy4	189	3	cGAS	cgas	NN
cord-259748-x7dq1sy4	189	4	can	can	MD
cord-259748-x7dq1sy4	189	5	partially	partially	RB
cord-259748-x7dq1sy4	189	6	enter	enter	VB
cord-259748-x7dq1sy4	189	7	the	the	DT
cord-259748-x7dq1sy4	189	8	nucleus	nucleus	NN
cord-259748-x7dq1sy4	189	9	and	and	CC
cord-259748-x7dq1sy4	189	10	interact	interact	VB
cord-259748-x7dq1sy4	189	11	with	with	IN
cord-259748-x7dq1sy4	189	12	IFI16	ifi16	NN
cord-259748-x7dq1sy4	189	13	to	to	TO
cord-259748-x7dq1sy4	189	14	promote	promote	VB
cord-259748-x7dq1sy4	189	15	its	-PRON-	PRP$
cord-259748-x7dq1sy4	189	16	stability	stability	NN
cord-259748-x7dq1sy4	189	17	(	(	-LRB-
cord-259748-x7dq1sy4	189	18	107	107	CD
cord-259748-x7dq1sy4	189	19	)	)	-RRB-
cord-259748-x7dq1sy4	189	20	.	.	.
cord-259748-x7dq1sy4	190	1	Therefore	therefore	RB
cord-259748-x7dq1sy4	190	2	,	,	,
cord-259748-x7dq1sy4	190	3	it	-PRON-	PRP
cord-259748-x7dq1sy4	190	4	is	be	VBZ
cord-259748-x7dq1sy4	190	5	inferred	infer	VBN
cord-259748-x7dq1sy4	190	6	that	that	IN
cord-259748-x7dq1sy4	190	7	during	during	IN
cord-259748-x7dq1sy4	190	8	viral	viral	JJ
cord-259748-x7dq1sy4	190	9	infection	infection	NN
cord-259748-x7dq1sy4	190	10	,	,	,
cord-259748-x7dq1sy4	190	11	IFI16	IFI16	NNP
cord-259748-x7dq1sy4	190	12	can	can	MD
cord-259748-x7dq1sy4	190	13	facilitate	facilitate	VB
cord-259748-x7dq1sy4	190	14	recognition	recognition	NN
cord-259748-x7dq1sy4	190	15	of	of	IN
cord-259748-x7dq1sy4	190	16	decapsidated	decapsidated	JJ
cord-259748-x7dq1sy4	190	17	viral	viral	JJ
cord-259748-x7dq1sy4	190	18	DNA	dna	NN
cord-259748-x7dq1sy4	190	19	in	in	IN
cord-259748-x7dq1sy4	190	20	the	the	DT
cord-259748-x7dq1sy4	190	21	nucleus	nucleus	NN
cord-259748-x7dq1sy4	190	22	,	,	,
cord-259748-x7dq1sy4	190	23	while	while	IN
cord-259748-x7dq1sy4	190	24	cGAS	cga	VBG
cord-259748-x7dq1sy4	190	25	in	in	IN
cord-259748-x7dq1sy4	190	26	the	the	DT
cord-259748-x7dq1sy4	190	27	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	190	28	engages	engage	VBZ
cord-259748-x7dq1sy4	190	29	with	with	IN
cord-259748-x7dq1sy4	190	30	viral	viral	JJ
cord-259748-x7dq1sy4	190	31	gene	gene	NN
cord-259748-x7dq1sy4	190	32	transcription	transcription	NN
cord-259748-x7dq1sy4	190	33	products	product	NNS
cord-259748-x7dq1sy4	190	34	(	(	-LRB-
cord-259748-x7dq1sy4	190	35	104	104	CD
cord-259748-x7dq1sy4	190	36	,	,	,
cord-259748-x7dq1sy4	190	37	108	108	CD
cord-259748-x7dq1sy4	190	38	)	)	-RRB-
cord-259748-x7dq1sy4	190	39	.	.	.
cord-259748-x7dq1sy4	191	1	However	however	RB
cord-259748-x7dq1sy4	191	2	,	,	,
cord-259748-x7dq1sy4	191	3	STING	sting	NN
cord-259748-x7dq1sy4	191	4	signaling	signaling	NN
cord-259748-x7dq1sy4	191	5	can	can	MD
cord-259748-x7dq1sy4	191	6	trigger	trigger	VB
cord-259748-x7dq1sy4	191	7	IFI16	ifi16	NN
cord-259748-x7dq1sy4	191	8	degradation	degradation	NN
cord-259748-x7dq1sy4	191	9	by	by	IN
cord-259748-x7dq1sy4	191	10	tripartite	tripartite	JJ
cord-259748-x7dq1sy4	191	11	motif	motif	NN
cord-259748-x7dq1sy4	191	12	-	-	:
cord-259748-x7dq1sy4	191	13	containing	contain	VBG
cord-259748-x7dq1sy4	191	14	21	21	CD
cord-259748-x7dq1sy4	191	15	(	(	-LRB-
cord-259748-x7dq1sy4	191	16	TRIM21	trim21	CD
cord-259748-x7dq1sy4	191	17	)	)	-RRB-
cord-259748-x7dq1sy4	191	18	ubiquitination	ubiquitination	NN
cord-259748-x7dq1sy4	191	19	(	(	-LRB-
cord-259748-x7dq1sy4	191	20	109	109	CD
cord-259748-x7dq1sy4	191	21	)	)	-RRB-
cord-259748-x7dq1sy4	191	22	.	.	.
cord-259748-x7dq1sy4	192	1	TLR	TLR	NNP
cord-259748-x7dq1sy4	192	2	is	be	VBZ
cord-259748-x7dq1sy4	192	3	also	also	RB
cord-259748-x7dq1sy4	192	4	an	an	DT
cord-259748-x7dq1sy4	192	5	important	important	JJ
cord-259748-x7dq1sy4	192	6	PRR	PRR	NNP
cord-259748-x7dq1sy4	192	7	for	for	IN
cord-259748-x7dq1sy4	192	8	multiple	multiple	JJ
cord-259748-x7dq1sy4	192	9	PAMPs	pamp	NNS
cord-259748-x7dq1sy4	192	10	(	(	-LRB-
cord-259748-x7dq1sy4	192	11	110	110	CD
cord-259748-x7dq1sy4	192	12	)	)	-RRB-
cord-259748-x7dq1sy4	192	13	.	.	.
cord-259748-x7dq1sy4	193	1	TIR	TIR	NNP
cord-259748-x7dq1sy4	193	2	domain	domain	NN
cord-259748-x7dq1sy4	193	3	-	-	HYPH
cord-259748-x7dq1sy4	193	4	containing	contain	VBG
cord-259748-x7dq1sy4	193	5	adaptor	adaptor	NN
cord-259748-x7dq1sy4	193	6	-	-	HYPH
cord-259748-x7dq1sy4	193	7	inducing	induce	VBG
cord-259748-x7dq1sy4	193	8	IFNβ	IFNβ	NNS
cord-259748-x7dq1sy4	193	9	(	(	-LRB-
cord-259748-x7dq1sy4	193	10	TRIF	TRIF	NNP
cord-259748-x7dq1sy4	193	11	)	)	-RRB-
cord-259748-x7dq1sy4	193	12	is	be	VBZ
cord-259748-x7dq1sy4	193	13	downstream	downstream	JJ
cord-259748-x7dq1sy4	193	14	of	of	IN
cord-259748-x7dq1sy4	193	15	several	several	JJ
cord-259748-x7dq1sy4	193	16	subtypes	subtype	NNS
cord-259748-x7dq1sy4	193	17	of	of	IN
cord-259748-x7dq1sy4	193	18	TLRs	tlr	NNS
cord-259748-x7dq1sy4	193	19	(	(	-LRB-
cord-259748-x7dq1sy4	193	20	including	include	VBG
cord-259748-x7dq1sy4	193	21	TLR3	TLR3	NNP
cord-259748-x7dq1sy4	193	22	)	)	-RRB-
cord-259748-x7dq1sy4	193	23	.	.	.
cord-259748-x7dq1sy4	194	1	TRIF	TRIF	NNP
cord-259748-x7dq1sy4	194	2	may	may	MD
cord-259748-x7dq1sy4	194	3	be	be	VB
cord-259748-x7dq1sy4	194	4	responsible	responsible	JJ
cord-259748-x7dq1sy4	194	5	for	for	IN
cord-259748-x7dq1sy4	194	6	interacting	interact	VBG
cord-259748-x7dq1sy4	194	7	with	with	IN
cord-259748-x7dq1sy4	194	8	STING	sting	NN
cord-259748-x7dq1sy4	194	9	and	and	CC
cord-259748-x7dq1sy4	194	10	helping	help	VBG
cord-259748-x7dq1sy4	194	11	the	the	DT
cord-259748-x7dq1sy4	194	12	dimerization	dimerization	NN
cord-259748-x7dq1sy4	194	13	of	of	IN
cord-259748-x7dq1sy4	194	14	STING	sting	NN
cord-259748-x7dq1sy4	194	15	(	(	-LRB-
cord-259748-x7dq1sy4	194	16	111	111	CD
cord-259748-x7dq1sy4	194	17	)	)	-RRB-
cord-259748-x7dq1sy4	194	18	.	.	.
cord-259748-x7dq1sy4	195	1	During	during	IN
cord-259748-x7dq1sy4	195	2	viral	viral	JJ
cord-259748-x7dq1sy4	195	3	infection	infection	NN
cord-259748-x7dq1sy4	195	4	,	,	,
cord-259748-x7dq1sy4	195	5	the	the	DT
cord-259748-x7dq1sy4	195	6	TLR9-myeloid	TLR9-myeloid	NNP
cord-259748-x7dq1sy4	195	7	differentiation	differentiation	NN
cord-259748-x7dq1sy4	195	8	primary	primary	JJ
cord-259748-x7dq1sy4	195	9	response	response	NN
cord-259748-x7dq1sy4	195	10	88	88	CD
cord-259748-x7dq1sy4	195	11	(	(	-LRB-
cord-259748-x7dq1sy4	195	12	MYd88)-IRF3/7	MYd88)-IRF3/7	NNP
cord-259748-x7dq1sy4	195	13	pathway	pathway	NN
cord-259748-x7dq1sy4	195	14	is	be	VBZ
cord-259748-x7dq1sy4	195	15	necessary	necessary	JJ
cord-259748-x7dq1sy4	195	16	for	for	IN
cord-259748-x7dq1sy4	195	17	mouse	mouse	NN
cord-259748-x7dq1sy4	195	18	monocytes	monocyte	NNS
cord-259748-x7dq1sy4	195	19	recruitment	recruitment	NN
cord-259748-x7dq1sy4	195	20	to	to	IN
cord-259748-x7dq1sy4	195	21	lymph	lymph	NN
cord-259748-x7dq1sy4	195	22	nodes	node	NNS
cord-259748-x7dq1sy4	195	23	,	,	,
cord-259748-x7dq1sy4	195	24	whereas	whereas	IN
cord-259748-x7dq1sy4	195	25	the	the	DT
cord-259748-x7dq1sy4	195	26	STING	sting	NN
cord-259748-x7dq1sy4	195	27	pathway	pathway	NN
cord-259748-x7dq1sy4	195	28	is	be	VBZ
cord-259748-x7dq1sy4	195	29	necessary	necessary	JJ
cord-259748-x7dq1sy4	195	30	for	for	IN
cord-259748-x7dq1sy4	195	31	local	local	JJ
cord-259748-x7dq1sy4	195	32	production	production	NN
cord-259748-x7dq1sy4	195	33	of	of	IN
cord-259748-x7dq1sy4	195	34	type	type	NN
cord-259748-x7dq1sy4	195	35	-	-	:
cord-259748-x7dq1sy4	195	36	I	-PRON-	PRP
cord-259748-x7dq1sy4	195	37	IFN	IFN	NNP
cord-259748-x7dq1sy4	195	38	(	(	-LRB-
cord-259748-x7dq1sy4	195	39	112	112	CD
cord-259748-x7dq1sy4	195	40	)	)	-RRB-
cord-259748-x7dq1sy4	195	41	.	.	.
cord-259748-x7dq1sy4	196	1	However	however	RB
cord-259748-x7dq1sy4	196	2	,	,	,
cord-259748-x7dq1sy4	196	3	STING	sting	NN
cord-259748-x7dq1sy4	196	4	signaling	signaling	NN
cord-259748-x7dq1sy4	196	5	can	can	MD
cord-259748-x7dq1sy4	196	6	induce	induce	VB
cord-259748-x7dq1sy4	196	7	suppressor	suppressor	NN
cord-259748-x7dq1sy4	196	8	of	of	IN
cord-259748-x7dq1sy4	196	9	cytokine	cytokine	NN
cord-259748-x7dq1sy4	196	10	signaling1	signaling1	NN
cord-259748-x7dq1sy4	196	11	(	(	-LRB-
cord-259748-x7dq1sy4	196	12	SOCS1	SOCS1	NNP
cord-259748-x7dq1sy4	196	13	)	)	-RRB-
cord-259748-x7dq1sy4	196	14	expression	expression	NN
cord-259748-x7dq1sy4	196	15	,	,	,
cord-259748-x7dq1sy4	196	16	which	which	WDT
cord-259748-x7dq1sy4	196	17	can	can	MD
cord-259748-x7dq1sy4	196	18	negatively	negatively	RB
cord-259748-x7dq1sy4	196	19	regulate	regulate	VB
cord-259748-x7dq1sy4	196	20	MyD88	myd88	JJ
cord-259748-x7dq1sy4	196	21	activity	activity	NN
cord-259748-x7dq1sy4	196	22	(	(	-LRB-
cord-259748-x7dq1sy4	196	23	113	113	CD
cord-259748-x7dq1sy4	196	24	)	)	-RRB-
cord-259748-x7dq1sy4	196	25	(	(	-LRB-
cord-259748-x7dq1sy4	196	26	Figure	figure	NN
cord-259748-x7dq1sy4	196	27	3C	3c	NN
cord-259748-x7dq1sy4	196	28	)	)	-RRB-
cord-259748-x7dq1sy4	196	29	.	.	.
cord-259748-x7dq1sy4	197	1	Oxidized	oxidized	JJ
cord-259748-x7dq1sy4	197	2	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	197	3	can	can	MD
cord-259748-x7dq1sy4	197	4	be	be	VB
cord-259748-x7dq1sy4	197	5	released	release	VBN
cord-259748-x7dq1sy4	197	6	into	into	IN
cord-259748-x7dq1sy4	197	7	the	the	DT
cord-259748-x7dq1sy4	197	8	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	197	9	during	during	IN
cord-259748-x7dq1sy4	197	10	cell	cell	NN
cord-259748-x7dq1sy4	197	11	stress	stress	NN
cord-259748-x7dq1sy4	197	12	elicited	elicit	VBN
cord-259748-x7dq1sy4	197	13	by	by	IN
cord-259748-x7dq1sy4	197	14	hypoxia	hypoxia	NN
cord-259748-x7dq1sy4	197	15	,	,	,
cord-259748-x7dq1sy4	197	16	viral	viral	JJ
cord-259748-x7dq1sy4	197	17	infection	infection	NN
cord-259748-x7dq1sy4	197	18	and	and	CC
cord-259748-x7dq1sy4	197	19	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	197	20	damage	damage	NN
cord-259748-x7dq1sy4	197	21	,	,	,
cord-259748-x7dq1sy4	197	22	etc	etc	FW
cord-259748-x7dq1sy4	197	23	.	.	FW
cord-259748-x7dq1sy4	197	24	;	;	,
cord-259748-x7dq1sy4	197	25	oxidized	oxidized	JJ
cord-259748-x7dq1sy4	197	26	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	197	27	is	be	VBZ
cord-259748-x7dq1sy4	197	28	resistant	resistant	JJ
cord-259748-x7dq1sy4	197	29	to	to	IN
cord-259748-x7dq1sy4	197	30	degradation	degradation	NN
cord-259748-x7dq1sy4	197	31	by	by	IN
cord-259748-x7dq1sy4	197	32	the	the	DT
cord-259748-x7dq1sy4	197	33	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	197	34	nuclease	nuclease	NN
cord-259748-x7dq1sy4	197	35	TREX1	TREX1	NNP
cord-259748-x7dq1sy4	198	1	(	(	-LRB-
cord-259748-x7dq1sy4	198	2	114	114	CD
cord-259748-x7dq1sy4	198	3	)	)	-RRB-
cord-259748-x7dq1sy4	198	4	.	.	.
cord-259748-x7dq1sy4	199	1	In	in	IN
cord-259748-x7dq1sy4	199	2	addition	addition	NN
cord-259748-x7dq1sy4	199	3	,	,	,
cord-259748-x7dq1sy4	199	4	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	199	5	accompanied	accompany	VBN
cord-259748-x7dq1sy4	199	6	with	with	IN
cord-259748-x7dq1sy4	199	7	TFAM	TFAM	NNP
cord-259748-x7dq1sy4	199	8	(	(	-LRB-
cord-259748-x7dq1sy4	199	9	a	a	DT
cord-259748-x7dq1sy4	199	10	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	199	11	-	-	HYPH
cord-259748-x7dq1sy4	199	12	binding	bind	VBG
cord-259748-x7dq1sy4	199	13	protein	protein	NN
cord-259748-x7dq1sy4	199	14	that	that	WDT
cord-259748-x7dq1sy4	199	15	can	can	MD
cord-259748-x7dq1sy4	199	16	bend	bend	VB
cord-259748-x7dq1sy4	199	17	mtDNA	mtDNA	NNP
cord-259748-x7dq1sy4	199	18	)	)	-RRB-
cord-259748-x7dq1sy4	199	19	is	be	VBZ
cord-259748-x7dq1sy4	199	20	also	also	RB
cord-259748-x7dq1sy4	199	21	a	a	DT
cord-259748-x7dq1sy4	199	22	reasonable	reasonable	JJ
cord-259748-x7dq1sy4	199	23	target	target	NN
cord-259748-x7dq1sy4	199	24	for	for	IN
cord-259748-x7dq1sy4	199	25	recognition	recognition	NN
cord-259748-x7dq1sy4	199	26	by	by	IN
cord-259748-x7dq1sy4	199	27	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	199	28	(	(	-LRB-
cord-259748-x7dq1sy4	199	29	21	21	CD
cord-259748-x7dq1sy4	199	30	,	,	,
cord-259748-x7dq1sy4	199	31	33	33	CD
cord-259748-x7dq1sy4	199	32	)	)	-RRB-
cord-259748-x7dq1sy4	199	33	.	.	.
cord-259748-x7dq1sy4	200	1	However	however	RB
cord-259748-x7dq1sy4	200	2	,	,	,
cord-259748-x7dq1sy4	200	3	during	during	IN
cord-259748-x7dq1sy4	200	4	regulated	regulated	JJ
cord-259748-x7dq1sy4	200	5	cell	cell	NN
cord-259748-x7dq1sy4	200	6	death	death	NN
cord-259748-x7dq1sy4	200	7	(	(	-LRB-
cord-259748-x7dq1sy4	200	8	as	as	IN
cord-259748-x7dq1sy4	200	9	represented	represent	VBN
cord-259748-x7dq1sy4	200	10	by	by	IN
cord-259748-x7dq1sy4	200	11	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	200	12	)	)	-RRB-
cord-259748-x7dq1sy4	200	13	,	,	,
cord-259748-x7dq1sy4	200	14	it	-PRON-	PRP
cord-259748-x7dq1sy4	200	15	undergoes	undergo	VBZ
cord-259748-x7dq1sy4	200	16	mtDNA	mtdna	JJ
cord-259748-x7dq1sy4	200	17	release	release	NN
cord-259748-x7dq1sy4	200	18	but	but	CC
cord-259748-x7dq1sy4	200	19	has	have	VBZ
cord-259748-x7dq1sy4	200	20	certain	certain	JJ
cord-259748-x7dq1sy4	200	21	mechanisms	mechanism	NNS
cord-259748-x7dq1sy4	200	22	to	to	TO
cord-259748-x7dq1sy4	200	23	ensure	ensure	VB
cord-259748-x7dq1sy4	200	24	a	a	DT
cord-259748-x7dq1sy4	200	25	minimal	minimal	JJ
cord-259748-x7dq1sy4	200	26	cGAS	cgas	NN
cord-259748-x7dq1sy4	200	27	-	-	HYPH
cord-259748-x7dq1sy4	200	28	STINGmediated	stingmediate	VBN
cord-259748-x7dq1sy4	200	29	immune	immune	JJ
cord-259748-x7dq1sy4	200	30	response	response	NN
cord-259748-x7dq1sy4	200	31	.	.	.
cord-259748-x7dq1sy4	201	1	Mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	201	2	outer	outer	JJ
cord-259748-x7dq1sy4	201	3	membrane	membrane	NN
cord-259748-x7dq1sy4	201	4	permeabilization	permeabilization	NN
cord-259748-x7dq1sy4	201	5	(	(	-LRB-
cord-259748-x7dq1sy4	201	6	MOMP	MOMP	NNP
cord-259748-x7dq1sy4	201	7	)	)	-RRB-
cord-259748-x7dq1sy4	201	8	activation	activation	NN
cord-259748-x7dq1sy4	201	9	,	,	,
cord-259748-x7dq1sy4	201	10	which	which	WDT
cord-259748-x7dq1sy4	201	11	is	be	VBZ
cord-259748-x7dq1sy4	201	12	executed	execute	VBN
cord-259748-x7dq1sy4	201	13	by	by	IN
cord-259748-x7dq1sy4	201	14	BCL-2-associated	BCL-2-associated	NNP
cord-259748-x7dq1sy4	201	15	X	X	NNP
cord-259748-x7dq1sy4	201	16	protein	protein	NN
cord-259748-x7dq1sy4	201	17	(	(	-LRB-
cord-259748-x7dq1sy4	201	18	BAX	BAX	NNP
cord-259748-x7dq1sy4	201	19	)	)	-RRB-
cord-259748-x7dq1sy4	201	20	and	and	CC
cord-259748-x7dq1sy4	201	21	BCL-2	BCL-2	NNP
cord-259748-x7dq1sy4	201	22	antagonist	antagonist	NN
cord-259748-x7dq1sy4	201	23	or	or	CC
cord-259748-x7dq1sy4	201	24	killer	killer	NN
cord-259748-x7dq1sy4	201	25	(	(	-LRB-
cord-259748-x7dq1sy4	201	26	BAK	BAK	NNP
cord-259748-x7dq1sy4	201	27	)	)	-RRB-
cord-259748-x7dq1sy4	201	28	,	,	,
cord-259748-x7dq1sy4	201	29	is	be	VBZ
cord-259748-x7dq1sy4	201	30	a	a	DT
cord-259748-x7dq1sy4	201	31	highly	highly	RB
cord-259748-x7dq1sy4	201	32	controlled	control	VBN
cord-259748-x7dq1sy4	201	33	conserved	conserved	JJ
cord-259748-x7dq1sy4	201	34	process	process	NN
cord-259748-x7dq1sy4	201	35	in	in	IN
cord-259748-x7dq1sy4	201	36	regulated	regulated	JJ
cord-259748-x7dq1sy4	201	37	cell	cell	NN
cord-259748-x7dq1sy4	201	38	FIGURE	figure	NN
cord-259748-x7dq1sy4	201	39	3	3	CD
cord-259748-x7dq1sy4	201	40	|	|	NNP
cord-259748-x7dq1sy4	201	41	Interaction	Interaction	NNP
cord-259748-x7dq1sy4	201	42	of	of	IN
cord-259748-x7dq1sy4	201	43	the	the	DT
cord-259748-x7dq1sy4	201	44	cGAS	cgas	JJ
cord-259748-x7dq1sy4	201	45	-	-	HYPH
cord-259748-x7dq1sy4	201	46	STING	sting	NN
cord-259748-x7dq1sy4	201	47	pathway	pathway	NN
cord-259748-x7dq1sy4	201	48	with	with	IN
cord-259748-x7dq1sy4	201	49	other	other	JJ
cord-259748-x7dq1sy4	201	50	DNA	dna	NN
cord-259748-x7dq1sy4	201	51	-	-	HYPH
cord-259748-x7dq1sy4	201	52	sensing	sense	VBG
cord-259748-x7dq1sy4	201	53	pathways	pathway	NNS
cord-259748-x7dq1sy4	201	54	and	and	CC
cord-259748-x7dq1sy4	201	55	its	-PRON-	PRP$
cord-259748-x7dq1sy4	201	56	role	role	NN
cord-259748-x7dq1sy4	201	57	in	in	IN
cord-259748-x7dq1sy4	201	58	cell	cell	NN
cord-259748-x7dq1sy4	201	59	survival	survival	NN
cord-259748-x7dq1sy4	201	60	.	.	.
cord-259748-x7dq1sy4	202	1	(	(	-LRB-
cord-259748-x7dq1sy4	202	2	A	a	NN
cord-259748-x7dq1sy4	202	3	)	)	-RRB-
cord-259748-x7dq1sy4	202	4	Absent	Absent	NNP
cord-259748-x7dq1sy4	202	5	in	in	IN
cord-259748-x7dq1sy4	202	6	melanoma2	melanoma2	NN
cord-259748-x7dq1sy4	202	7	(	(	-LRB-
cord-259748-x7dq1sy4	202	8	AIM2	AIM2	NNP
cord-259748-x7dq1sy4	202	9	)	)	-RRB-
cord-259748-x7dq1sy4	202	10	pathway	pathway	NN
cord-259748-x7dq1sy4	202	11	and	and	CC
cord-259748-x7dq1sy4	202	12	pyroptosis	pyroptosis	NNP
cord-259748-x7dq1sy4	202	13	and	and	CC
cord-259748-x7dq1sy4	202	14	necroptosis	necroptosis	NNP
cord-259748-x7dq1sy4	202	15	.	.	.
cord-259748-x7dq1sy4	203	1	AIM2	AIM2	NNP
cord-259748-x7dq1sy4	203	2	can	can	MD
cord-259748-x7dq1sy4	203	3	be	be	VB
cord-259748-x7dq1sy4	203	4	triggered	trigger	VBN
cord-259748-x7dq1sy4	203	5	by	by	IN
cord-259748-x7dq1sy4	203	6	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	203	7	and	and	CC
cord-259748-x7dq1sy4	203	8	form	form	VB
cord-259748-x7dq1sy4	203	9	an	an	DT
cord-259748-x7dq1sy4	203	10	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	203	11	,	,	,
cord-259748-x7dq1sy4	203	12	consequently	consequently	RB
cord-259748-x7dq1sy4	203	13	triggering	trigger	VBG
cord-259748-x7dq1sy4	203	14	interleukin	interleukin	NN
cord-259748-x7dq1sy4	203	15	(	(	-LRB-
cord-259748-x7dq1sy4	203	16	IL)-1	IL)-1	``
cord-259748-x7dq1sy4	203	17	production	production	NN
cord-259748-x7dq1sy4	203	18	and	and	CC
cord-259748-x7dq1sy4	203	19	pyroptosis	pyroptosis	NN
cord-259748-x7dq1sy4	203	20	.	.	.
cord-259748-x7dq1sy4	204	1	Stimulator	Stimulator	NNP
cord-259748-x7dq1sy4	204	2	of	of	IN
cord-259748-x7dq1sy4	204	3	interferon	interferon	NN
cord-259748-x7dq1sy4	204	4	genes	gene	NNS
cord-259748-x7dq1sy4	204	5	(	(	-LRB-
cord-259748-x7dq1sy4	204	6	STING	sting	NN
cord-259748-x7dq1sy4	204	7	)	)	-RRB-
cord-259748-x7dq1sy4	204	8	trafficking	traffic	VBG
cord-259748-x7dq1sy4	204	9	to	to	IN
cord-259748-x7dq1sy4	204	10	the	the	DT
cord-259748-x7dq1sy4	204	11	lysosome	lysosome	NN
cord-259748-x7dq1sy4	204	12	ruptures	rupture	VBZ
cord-259748-x7dq1sy4	204	13	the	the	DT
cord-259748-x7dq1sy4	204	14	lysosome	lysosome	NN
cord-259748-x7dq1sy4	204	15	membrane	membrane	NN
cord-259748-x7dq1sy4	204	16	,	,	,
cord-259748-x7dq1sy4	204	17	resulting	result	VBG
cord-259748-x7dq1sy4	204	18	in	in	IN
cord-259748-x7dq1sy4	204	19	K	K	NNP
cord-259748-x7dq1sy4	204	20	+	+	CC
cord-259748-x7dq1sy4	204	21	efflux	efflux	NN
cord-259748-x7dq1sy4	204	22	and	and	CC
cord-259748-x7dq1sy4	204	23	activation	activation	NN
cord-259748-x7dq1sy4	204	24	of	of	IN
cord-259748-x7dq1sy4	204	25	the	the	DT
cord-259748-x7dq1sy4	204	26	NLRP3	NLRP3	NNP
cord-259748-x7dq1sy4	204	27	inflammasome	inflammasome	NNP
cord-259748-x7dq1sy4	204	28	,	,	,
cord-259748-x7dq1sy4	204	29	leading	lead	VBG
cord-259748-x7dq1sy4	204	30	to	to	IN
cord-259748-x7dq1sy4	204	31	pyroptosis	pyroptosis	NNP
cord-259748-x7dq1sy4	204	32	.	.	.
cord-259748-x7dq1sy4	205	1	Cyclic	cyclic	JJ
cord-259748-x7dq1sy4	205	2	-	-	HYPH
cord-259748-x7dq1sy4	205	3	GMP	GMP	NNP
cord-259748-x7dq1sy4	205	4	-	-	HYPH
cord-259748-x7dq1sy4	205	5	AMP	AMP	NNP
cord-259748-x7dq1sy4	205	6	synthase	synthase	NN
cord-259748-x7dq1sy4	205	7	(	(	-LRB-
cord-259748-x7dq1sy4	205	8	cGAS	cgas	NN
cord-259748-x7dq1sy4	205	9	)	)	-RRB-
cord-259748-x7dq1sy4	205	10	and	and	CC
cord-259748-x7dq1sy4	205	11	interferon	interferon	NN
cord-259748-x7dq1sy4	205	12	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	205	13	factor	factor	NN
cord-259748-x7dq1sy4	205	14	3	3	CD
cord-259748-x7dq1sy4	205	15	(	(	-LRB-
cord-259748-x7dq1sy4	205	16	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	205	17	)	)	-RRB-
cord-259748-x7dq1sy4	205	18	can	can	MD
cord-259748-x7dq1sy4	205	19	be	be	VB
cord-259748-x7dq1sy4	205	20	a	a	DT
cord-259748-x7dq1sy4	205	21	target	target	NN
cord-259748-x7dq1sy4	205	22	for	for	IN
cord-259748-x7dq1sy4	205	23	caspase-1	caspase-1	NNP
cord-259748-x7dq1sy4	205	24	cleaving	cleaving	NN
cord-259748-x7dq1sy4	205	25	.	.	.
cord-259748-x7dq1sy4	206	1	Gasdermin	gasdermin	NN
cord-259748-x7dq1sy4	206	2	D	d	NN
cord-259748-x7dq1sy4	206	3	can	can	MD
cord-259748-x7dq1sy4	206	4	lead	lead	VB
cord-259748-x7dq1sy4	206	5	to	to	IN
cord-259748-x7dq1sy4	206	6	K	k	NN
cord-259748-x7dq1sy4	206	7	+	+	CC
cord-259748-x7dq1sy4	206	8	efflux	efflux	NN
cord-259748-x7dq1sy4	206	9	and	and	CC
cord-259748-x7dq1sy4	206	10	inhibition	inhibition	NN
cord-259748-x7dq1sy4	206	11	of	of	IN
cord-259748-x7dq1sy4	206	12	cGAS	cgas	NN
cord-259748-x7dq1sy4	206	13	.	.	.
cord-259748-x7dq1sy4	207	1	(	(	-LRB-
cord-259748-x7dq1sy4	207	2	B	b	NN
cord-259748-x7dq1sy4	207	3	)	)	-RRB-
cord-259748-x7dq1sy4	208	1	Interferon	interferon	NN
cord-259748-x7dq1sy4	208	2	gamma	gamma	NN
cord-259748-x7dq1sy4	208	3	inducible	inducible	JJ
cord-259748-x7dq1sy4	208	4	protein	protein	NN
cord-259748-x7dq1sy4	208	5	16	16	CD
cord-259748-x7dq1sy4	208	6	(	(	-LRB-
cord-259748-x7dq1sy4	208	7	IFI16	ifi16	NN
cord-259748-x7dq1sy4	208	8	)	)	-RRB-
cord-259748-x7dq1sy4	208	9	.	.	.
cord-259748-x7dq1sy4	209	1	IFI16	ifi16	NN
cord-259748-x7dq1sy4	209	2	can	can	MD
cord-259748-x7dq1sy4	209	3	be	be	VB
cord-259748-x7dq1sy4	209	4	transported	transport	VBN
cord-259748-x7dq1sy4	209	5	to	to	IN
cord-259748-x7dq1sy4	209	6	the	the	DT
cord-259748-x7dq1sy4	209	7	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	209	8	to	to	TO
cord-259748-x7dq1sy4	209	9	help	help	VB
cord-259748-x7dq1sy4	209	10	to	to	TO
cord-259748-x7dq1sy4	209	11	recruit	recruit	VB
cord-259748-x7dq1sy4	209	12	STING	sting	NN
cord-259748-x7dq1sy4	209	13	and	and	CC
cord-259748-x7dq1sy4	209	14	TANK	tank	NN
cord-259748-x7dq1sy4	209	15	binding	binding	NN
cord-259748-x7dq1sy4	209	16	kinase	kinase	NN
cord-259748-x7dq1sy4	209	17	1	1	CD
cord-259748-x7dq1sy4	209	18	(	(	-LRB-
cord-259748-x7dq1sy4	209	19	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	209	20	)	)	-RRB-
cord-259748-x7dq1sy4	209	21	.	.	.
cord-259748-x7dq1sy4	210	1	IFI16	IFI16	NNP
cord-259748-x7dq1sy4	210	2	as	as	IN
cord-259748-x7dq1sy4	210	3	a	a	DT
cord-259748-x7dq1sy4	210	4	PYHIN	PYHIN	NNP
cord-259748-x7dq1sy4	210	5	family	family	NN
cord-259748-x7dq1sy4	210	6	protein	protein	NN
cord-259748-x7dq1sy4	210	7	may	may	MD
cord-259748-x7dq1sy4	210	8	form	form	VB
cord-259748-x7dq1sy4	210	9	the	the	DT
cord-259748-x7dq1sy4	210	10	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	210	11	only	only	RB
cord-259748-x7dq1sy4	210	12	in	in	IN
cord-259748-x7dq1sy4	210	13	theory	theory	NN
cord-259748-x7dq1sy4	210	14	.	.	.
cord-259748-x7dq1sy4	211	1	(	(	-LRB-
cord-259748-x7dq1sy4	211	2	C	C	NNP
cord-259748-x7dq1sy4	211	3	)	)	-RRB-
cord-259748-x7dq1sy4	211	4	Toll	toll	NN
cord-259748-x7dq1sy4	211	5	-	-	HYPH
cord-259748-x7dq1sy4	211	6	like	like	JJ
cord-259748-x7dq1sy4	211	7	receptor	receptor	NN
cord-259748-x7dq1sy4	211	8	(	(	-LRB-
cord-259748-x7dq1sy4	211	9	TLR	TLR	NNP
cord-259748-x7dq1sy4	211	10	)	)	-RRB-
cord-259748-x7dq1sy4	211	11	pathway	pathway	NN
cord-259748-x7dq1sy4	211	12	.	.	.
cord-259748-x7dq1sy4	212	1	TIR	TIR	NNP
cord-259748-x7dq1sy4	212	2	domain	domain	NN
cord-259748-x7dq1sy4	212	3	-	-	HYPH
cord-259748-x7dq1sy4	212	4	containing	contain	VBG
cord-259748-x7dq1sy4	212	5	adaptor	adaptor	NN
cord-259748-x7dq1sy4	212	6	-	-	HYPH
cord-259748-x7dq1sy4	212	7	inducing	induce	VBG
cord-259748-x7dq1sy4	212	8	IFNβ	IFNβ	NNS
cord-259748-x7dq1sy4	213	1	(	(	-LRB-
cord-259748-x7dq1sy4	213	2	TRIF	TRIF	NNP
cord-259748-x7dq1sy4	213	3	)	)	-RRB-
cord-259748-x7dq1sy4	213	4	may	may	MD
cord-259748-x7dq1sy4	213	5	be	be	VB
cord-259748-x7dq1sy4	213	6	responsible	responsible	JJ
cord-259748-x7dq1sy4	213	7	for	for	IN
cord-259748-x7dq1sy4	213	8	helping	help	VBG
cord-259748-x7dq1sy4	213	9	the	the	DT
cord-259748-x7dq1sy4	213	10	dimerization	dimerization	NN
cord-259748-x7dq1sy4	213	11	of	of	IN
cord-259748-x7dq1sy4	213	12	STING	sting	NN
cord-259748-x7dq1sy4	213	13	.	.	.
cord-259748-x7dq1sy4	214	1	STING	sting	NN
cord-259748-x7dq1sy4	214	2	signaling	signaling	NN
cord-259748-x7dq1sy4	214	3	can	can	MD
cord-259748-x7dq1sy4	214	4	induce	induce	VB
cord-259748-x7dq1sy4	214	5	suppressor	suppressor	NN
cord-259748-x7dq1sy4	214	6	of	of	IN
cord-259748-x7dq1sy4	214	7	cytokine	cytokine	NN
cord-259748-x7dq1sy4	214	8	signaling	signal	VBG
cord-259748-x7dq1sy4	214	9	1	1	CD
cord-259748-x7dq1sy4	214	10	(	(	-LRB-
cord-259748-x7dq1sy4	214	11	SOCS1	SOCS1	NNP
cord-259748-x7dq1sy4	214	12	)	)	-RRB-
cord-259748-x7dq1sy4	214	13	expression	expression	NN
cord-259748-x7dq1sy4	214	14	,	,	,
cord-259748-x7dq1sy4	214	15	which	which	WDT
cord-259748-x7dq1sy4	214	16	negatively	negatively	RB
cord-259748-x7dq1sy4	214	17	regulates	regulate	VBZ
cord-259748-x7dq1sy4	214	18	MyD88	myd88	JJ
cord-259748-x7dq1sy4	214	19	activity	activity	NN
cord-259748-x7dq1sy4	214	20	.	.	.
cord-259748-x7dq1sy4	215	1	(	(	-LRB-
cord-259748-x7dq1sy4	215	2	D	d	NN
cord-259748-x7dq1sy4	215	3	)	)	-RRB-
cord-259748-x7dq1sy4	215	4	Apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	215	5	.	.	.
cord-259748-x7dq1sy4	216	1	Mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	216	2	outer	outer	JJ
cord-259748-x7dq1sy4	216	3	membrane	membrane	NN
cord-259748-x7dq1sy4	216	4	permeabilization	permeabilization	NN
cord-259748-x7dq1sy4	216	5	(	(	-LRB-
cord-259748-x7dq1sy4	216	6	MOMP	MOMP	NNP
cord-259748-x7dq1sy4	216	7	)	)	-RRB-
cord-259748-x7dq1sy4	216	8	formed	form	VBN
cord-259748-x7dq1sy4	216	9	by	by	IN
cord-259748-x7dq1sy4	216	10	BAX	BAX	NNP
cord-259748-x7dq1sy4	216	11	/	/	SYM
cord-259748-x7dq1sy4	216	12	BAK	BAK	NNP
cord-259748-x7dq1sy4	216	13	induced	induce	VBN
cord-259748-x7dq1sy4	216	14	by	by	IN
cord-259748-x7dq1sy4	216	15	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	216	16	stress	stress	NN
cord-259748-x7dq1sy4	216	17	can	can	MD
cord-259748-x7dq1sy4	216	18	release	release	VB
cord-259748-x7dq1sy4	216	19	oxidized	oxidize	VBN
cord-259748-x7dq1sy4	216	20	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	216	21	DNA	dna	NN
cord-259748-x7dq1sy4	216	22	(	(	-LRB-
cord-259748-x7dq1sy4	216	23	mtDNA	mtDNA	NNP
cord-259748-x7dq1sy4	216	24	)	)	-RRB-
cord-259748-x7dq1sy4	216	25	and	and	CC
cord-259748-x7dq1sy4	216	26	cytochrome	cytochrome	NN
cord-259748-x7dq1sy4	216	27	c	c	NN
cord-259748-x7dq1sy4	216	28	into	into	IN
cord-259748-x7dq1sy4	216	29	the	the	DT
cord-259748-x7dq1sy4	216	30	cytosol	cytosol	NN
cord-259748-x7dq1sy4	216	31	.	.	.
cord-259748-x7dq1sy4	217	1	Oxidized	oxidized	JJ
cord-259748-x7dq1sy4	217	2	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	217	3	is	be	VBZ
cord-259748-x7dq1sy4	217	4	a	a	DT
cord-259748-x7dq1sy4	217	5	suitable	suitable	JJ
cord-259748-x7dq1sy4	217	6	ligand	ligand	NN
cord-259748-x7dq1sy4	217	7	for	for	IN
cord-259748-x7dq1sy4	217	8	cGAS	cgas	NN
cord-259748-x7dq1sy4	217	9	recognition	recognition	NN
cord-259748-x7dq1sy4	217	10	and	and	CC
cord-259748-x7dq1sy4	217	11	is	be	VBZ
cord-259748-x7dq1sy4	217	12	resistant	resistant	JJ
cord-259748-x7dq1sy4	217	13	to	to	IN
cord-259748-x7dq1sy4	217	14	DNaseIII	DNaseIII	NNP
cord-259748-x7dq1sy4	217	15	(	(	-LRB-
cord-259748-x7dq1sy4	217	16	TREX1	TREX1	NNP
cord-259748-x7dq1sy4	217	17	)	)	-RRB-
cord-259748-x7dq1sy4	217	18	degradation	degradation	NN
cord-259748-x7dq1sy4	217	19	.	.	.
cord-259748-x7dq1sy4	218	1	Cytochrome	cytochrome	NN
cord-259748-x7dq1sy4	218	2	c	c	NN
cord-259748-x7dq1sy4	218	3	binds	bind	VBZ
cord-259748-x7dq1sy4	218	4	to	to	IN
cord-259748-x7dq1sy4	218	5	apoptotic	apoptotic	JJ
cord-259748-x7dq1sy4	218	6	protease	protease	NN
cord-259748-x7dq1sy4	218	7	-	-	HYPH
cord-259748-x7dq1sy4	218	8	activating	activate	VBG
cord-259748-x7dq1sy4	218	9	factor	factor	NN
cord-259748-x7dq1sy4	218	10	1	1	CD
cord-259748-x7dq1sy4	218	11	(	(	-LRB-
cord-259748-x7dq1sy4	218	12	APAF1	apaf1	NN
cord-259748-x7dq1sy4	218	13	)	)	-RRB-
cord-259748-x7dq1sy4	218	14	and	and	CC
cord-259748-x7dq1sy4	218	15	initiates	initiate	VBZ
cord-259748-x7dq1sy4	218	16	the	the	DT
cord-259748-x7dq1sy4	218	17	formation	formation	NN
cord-259748-x7dq1sy4	218	18	of	of	IN
cord-259748-x7dq1sy4	218	19	an	an	DT
cord-259748-x7dq1sy4	218	20	apoptosome	apoptosome	NN
cord-259748-x7dq1sy4	218	21	cooperatively	cooperatively	RB
cord-259748-x7dq1sy4	218	22	with	with	IN
cord-259748-x7dq1sy4	218	23	caspase-9	caspase-9	NNP
cord-259748-x7dq1sy4	218	24	to	to	TO
cord-259748-x7dq1sy4	218	25	activate	activate	VB
cord-259748-x7dq1sy4	218	26	caspase-3	caspase-3	NNP
cord-259748-x7dq1sy4	218	27	,	,	,
cord-259748-x7dq1sy4	218	28	which	which	WDT
cord-259748-x7dq1sy4	218	29	can	can	MD
cord-259748-x7dq1sy4	218	30	induce	induce	VB
cord-259748-x7dq1sy4	218	31	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	218	32	.	.	.
cord-259748-x7dq1sy4	219	1	Caspase-3	Caspase-3	NNP
cord-259748-x7dq1sy4	219	2	can	can	MD
cord-259748-x7dq1sy4	219	3	cleave	cleave	VB
cord-259748-x7dq1sy4	219	4	cGAS	cgas	NN
cord-259748-x7dq1sy4	219	5	.	.	.
cord-259748-x7dq1sy4	219	6	death	death	NN
cord-259748-x7dq1sy4	219	7	.	.	.
cord-259748-x7dq1sy4	220	1	BAK	BAK	NNP
cord-259748-x7dq1sy4	220	2	and	and	CC
cord-259748-x7dq1sy4	220	3	BAX	BAX	NNP
cord-259748-x7dq1sy4	220	4	activated	activate	VBD
cord-259748-x7dq1sy4	220	5	by	by	IN
cord-259748-x7dq1sy4	220	6	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	220	7	signals	signal	NNS
cord-259748-x7dq1sy4	220	8	cooperatively	cooperatively	RB
cord-259748-x7dq1sy4	220	9	form	form	VBP
cord-259748-x7dq1sy4	220	10	a	a	DT
cord-259748-x7dq1sy4	220	11	pore	pore	NN
cord-259748-x7dq1sy4	220	12	-	-	HYPH
cord-259748-x7dq1sy4	220	13	like	like	JJ
cord-259748-x7dq1sy4	220	14	conformation	conformation	NN
cord-259748-x7dq1sy4	220	15	on	on	IN
cord-259748-x7dq1sy4	220	16	the	the	DT
cord-259748-x7dq1sy4	220	17	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	220	18	outer	outer	JJ
cord-259748-x7dq1sy4	220	19	membrane	membrane	NN
cord-259748-x7dq1sy4	220	20	,	,	,
cord-259748-x7dq1sy4	220	21	leading	lead	VBG
cord-259748-x7dq1sy4	220	22	to	to	IN
cord-259748-x7dq1sy4	220	23	a	a	DT
cord-259748-x7dq1sy4	220	24	permeability	permeability	NN
cord-259748-x7dq1sy4	220	25	change	change	NN
cord-259748-x7dq1sy4	220	26	of	of	IN
cord-259748-x7dq1sy4	220	27	outer	outer	NN
cord-259748-x7dq1sy4	220	28	and	and	CC
cord-259748-x7dq1sy4	220	29	also	also	RB
cord-259748-x7dq1sy4	220	30	inner	inner	JJ
cord-259748-x7dq1sy4	220	31	membranes	membrane	NNS
cord-259748-x7dq1sy4	220	32	(	(	-LRB-
cord-259748-x7dq1sy4	220	33	115	115	CD
cord-259748-x7dq1sy4	220	34	,	,	,
cord-259748-x7dq1sy4	220	35	116	116	CD
cord-259748-x7dq1sy4	220	36	)	)	-RRB-
cord-259748-x7dq1sy4	220	37	.	.	.
cord-259748-x7dq1sy4	221	1	Consequently	consequently	RB
cord-259748-x7dq1sy4	221	2	,	,	,
cord-259748-x7dq1sy4	221	3	the	the	DT
cord-259748-x7dq1sy4	221	4	mitochondrial	mitochondrial	NN
cord-259748-x7dq1sy4	221	5	matrix	matrix	NN
cord-259748-x7dq1sy4	221	6	,	,	,
cord-259748-x7dq1sy4	221	7	including	include	VBG
cord-259748-x7dq1sy4	221	8	cytochrome	cytochrome	NN
cord-259748-x7dq1sy4	221	9	C	c	NN
cord-259748-x7dq1sy4	221	10	and	and	CC
cord-259748-x7dq1sy4	221	11	oxidized	oxidize	VBN
cord-259748-x7dq1sy4	221	12	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	221	13	-	-	HYPH
cord-259748-x7dq1sy4	221	14	TFAM	TFAM	NNP
cord-259748-x7dq1sy4	221	15	,	,	,
cord-259748-x7dq1sy4	221	16	is	be	VBZ
cord-259748-x7dq1sy4	221	17	released	release	VBN
cord-259748-x7dq1sy4	221	18	into	into	IN
cord-259748-x7dq1sy4	221	19	the	the	DT
cord-259748-x7dq1sy4	221	20	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	221	21	(	(	-LRB-
cord-259748-x7dq1sy4	221	22	115	115	CD
cord-259748-x7dq1sy4	221	23	,	,	,
cord-259748-x7dq1sy4	221	24	117	117	CD
cord-259748-x7dq1sy4	221	25	)	)	-RRB-
cord-259748-x7dq1sy4	221	26	.	.	.
cord-259748-x7dq1sy4	222	1	Cytochrome	cytochrome	NN
cord-259748-x7dq1sy4	222	2	C	c	NN
cord-259748-x7dq1sy4	222	3	binds	bind	VBZ
cord-259748-x7dq1sy4	222	4	to	to	IN
cord-259748-x7dq1sy4	222	5	apoptotic	apoptotic	JJ
cord-259748-x7dq1sy4	222	6	protease	protease	NN
cord-259748-x7dq1sy4	222	7	-	-	HYPH
cord-259748-x7dq1sy4	222	8	activating	activate	VBG
cord-259748-x7dq1sy4	222	9	factor	factor	NN
cord-259748-x7dq1sy4	222	10	1	1	CD
cord-259748-x7dq1sy4	222	11	(	(	-LRB-
cord-259748-x7dq1sy4	222	12	APAF1	apaf1	NN
cord-259748-x7dq1sy4	222	13	)	)	-RRB-
cord-259748-x7dq1sy4	222	14	and	and	CC
cord-259748-x7dq1sy4	222	15	initiates	initiate	VBZ
cord-259748-x7dq1sy4	222	16	the	the	DT
cord-259748-x7dq1sy4	222	17	formation	formation	NN
cord-259748-x7dq1sy4	222	18	of	of	IN
cord-259748-x7dq1sy4	222	19	the	the	DT
cord-259748-x7dq1sy4	222	20	apoptosome	apoptosome	NN
cord-259748-x7dq1sy4	222	21	cooperatively	cooperatively	RB
cord-259748-x7dq1sy4	222	22	with	with	IN
cord-259748-x7dq1sy4	222	23	caspase-9	caspase-9	NNP
cord-259748-x7dq1sy4	222	24	,	,	,
cord-259748-x7dq1sy4	222	25	which	which	WDT
cord-259748-x7dq1sy4	222	26	further	further	RB
cord-259748-x7dq1sy4	222	27	triggers	trigger	VBZ
cord-259748-x7dq1sy4	222	28	the	the	DT
cord-259748-x7dq1sy4	222	29	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	222	30	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	222	31	program	program	NN
cord-259748-x7dq1sy4	222	32	(	(	-LRB-
cord-259748-x7dq1sy4	222	33	117	117	CD
cord-259748-x7dq1sy4	222	34	)	)	-RRB-
cord-259748-x7dq1sy4	222	35	.	.	.
cord-259748-x7dq1sy4	223	1	In	in	IN
cord-259748-x7dq1sy4	223	2	vivo	vivo	NN
cord-259748-x7dq1sy4	223	3	and	and	CC
cord-259748-x7dq1sy4	223	4	in	in	IN
cord-259748-x7dq1sy4	223	5	vitro	vitro	FW
cord-259748-x7dq1sy4	223	6	studies	study	NNS
cord-259748-x7dq1sy4	223	7	have	have	VBP
cord-259748-x7dq1sy4	223	8	shown	show	VBN
cord-259748-x7dq1sy4	223	9	that	that	IN
cord-259748-x7dq1sy4	223	10	an	an	DT
cord-259748-x7dq1sy4	223	11	absence	absence	NN
cord-259748-x7dq1sy4	223	12	of	of	IN
cord-259748-x7dq1sy4	223	13	caspase-9	caspase-9	NNP
cord-259748-x7dq1sy4	223	14	is	be	VBZ
cord-259748-x7dq1sy4	223	15	associated	associate	VBN
cord-259748-x7dq1sy4	223	16	with	with	IN
cord-259748-x7dq1sy4	223	17	greater	great	JJR
cord-259748-x7dq1sy4	223	18	release	release	NN
cord-259748-x7dq1sy4	223	19	of	of	IN
cord-259748-x7dq1sy4	223	20	type	type	NN
cord-259748-x7dq1sy4	223	21	-	-	:
cord-259748-x7dq1sy4	223	22	I	-PRON-	PRP
cord-259748-x7dq1sy4	223	23	IFN	IFN	NNP
cord-259748-x7dq1sy4	223	24	(	(	-LRB-
cord-259748-x7dq1sy4	223	25	43	43	CD
cord-259748-x7dq1sy4	223	26	,	,	,
cord-259748-x7dq1sy4	223	27	117	117	CD
cord-259748-x7dq1sy4	223	28	)	)	-RRB-
cord-259748-x7dq1sy4	223	29	.	.	.
cord-259748-x7dq1sy4	224	1	This	this	DT
cord-259748-x7dq1sy4	224	2	occurs	occur	VBZ
cord-259748-x7dq1sy4	224	3	because	because	IN
cord-259748-x7dq1sy4	224	4	caspase-9	caspase-9	NNP
cord-259748-x7dq1sy4	224	5	and	and	CC
cord-259748-x7dq1sy4	224	6	its	-PRON-	PRP$
cord-259748-x7dq1sy4	224	7	downstream	downstream	NN
cord-259748-x7dq1sy4	224	8	caspase-3	caspase-3	NNP
cord-259748-x7dq1sy4	224	9	can	can	MD
cord-259748-x7dq1sy4	224	10	cleave	cleave	VB
cord-259748-x7dq1sy4	224	11	cGAS	cgas	NN
cord-259748-x7dq1sy4	224	12	and	and	CC
cord-259748-x7dq1sy4	224	13	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	224	14	to	to	TO
cord-259748-x7dq1sy4	224	15	restrain	restrain	VB
cord-259748-x7dq1sy4	224	16	deleterious	deleterious	JJ
cord-259748-x7dq1sy4	224	17	inflammation	inflammation	NN
cord-259748-x7dq1sy4	224	18	(	(	-LRB-
cord-259748-x7dq1sy4	224	19	118	118	CD
cord-259748-x7dq1sy4	224	20	)	)	-RRB-
cord-259748-x7dq1sy4	224	21	(	(	-LRB-
cord-259748-x7dq1sy4	224	22	Figure	Figure	NNP
cord-259748-x7dq1sy4	224	23	3D	3d	NN
cord-259748-x7dq1sy4	224	24	)	)	-RRB-
cord-259748-x7dq1sy4	224	25	.	.	.
cord-259748-x7dq1sy4	225	1	The	the	DT
cord-259748-x7dq1sy4	225	2	cGAS	cgas	JJ
cord-259748-x7dq1sy4	225	3	-	-	HYPH
cord-259748-x7dq1sy4	225	4	STING	sting	NN
cord-259748-x7dq1sy4	225	5	pathway	pathway	NN
cord-259748-x7dq1sy4	225	6	can	can	MD
cord-259748-x7dq1sy4	225	7	also	also	RB
cord-259748-x7dq1sy4	225	8	initiate	initiate	VB
cord-259748-x7dq1sy4	225	9	programmed	program	VBN
cord-259748-x7dq1sy4	225	10	cell	cell	NN
cord-259748-x7dq1sy4	225	11	death	death	NN
cord-259748-x7dq1sy4	225	12	.	.	.
cord-259748-x7dq1sy4	226	1	Activation	activation	NN
cord-259748-x7dq1sy4	226	2	of	of	IN
cord-259748-x7dq1sy4	226	3	STING	sting	NN
cord-259748-x7dq1sy4	226	4	enhances	enhance	VBZ
cord-259748-x7dq1sy4	226	5	phosphorylation	phosphorylation	NN
cord-259748-x7dq1sy4	226	6	and	and	CC
cord-259748-x7dq1sy4	226	7	activation	activation	NN
cord-259748-x7dq1sy4	226	8	of	of	IN
cord-259748-x7dq1sy4	226	9	receptor	receptor	NN
cord-259748-x7dq1sy4	226	10	interacting	interact	VBG
cord-259748-x7dq1sy4	226	11	serine	serine	NN
cord-259748-x7dq1sy4	226	12	/	/	SYM
cord-259748-x7dq1sy4	226	13	threonine	threonine	NN
cord-259748-x7dq1sy4	226	14	kinase	kinase	NN
cord-259748-x7dq1sy4	226	15	3	3	CD
cord-259748-x7dq1sy4	226	16	(	(	-LRB-
cord-259748-x7dq1sy4	226	17	RIP3	RIP3	NNP
cord-259748-x7dq1sy4	226	18	)	)	-RRB-
cord-259748-x7dq1sy4	226	19	and	and	CC
cord-259748-x7dq1sy4	226	20	mixed	mixed	JJ
cord-259748-x7dq1sy4	226	21	lineage	lineage	NN
cord-259748-x7dq1sy4	226	22	kinase	kinase	NN
cord-259748-x7dq1sy4	226	23	domain	domain	NN
cord-259748-x7dq1sy4	226	24	-	-	HYPH
cord-259748-x7dq1sy4	226	25	like	like	JJ
cord-259748-x7dq1sy4	226	26	pseudokinase	pseudokinase	NN
cord-259748-x7dq1sy4	226	27	(	(	-LRB-
cord-259748-x7dq1sy4	226	28	MLKL	MLKL	NNP
cord-259748-x7dq1sy4	226	29	)	)	-RRB-
cord-259748-x7dq1sy4	226	30	.	.	.
cord-259748-x7dq1sy4	227	1	Proapoptotic	Proapoptotic	NNP
cord-259748-x7dq1sy4	227	2	BCL2	BCL2	NNP
cord-259748-x7dq1sy4	227	3	binding	bind	VBG
cord-259748-x7dq1sy4	227	4	component	component	NN
cord-259748-x7dq1sy4	227	5	3	3	CD
cord-259748-x7dq1sy4	227	6	(	(	-LRB-
cord-259748-x7dq1sy4	227	7	PUMA	PUMA	NNP
cord-259748-x7dq1sy4	227	8	)	)	-RRB-
cord-259748-x7dq1sy4	227	9	,	,	,
cord-259748-x7dq1sy4	227	10	a	a	DT
cord-259748-x7dq1sy4	227	11	member	member	NN
cord-259748-x7dq1sy4	227	12	of	of	IN
cord-259748-x7dq1sy4	227	13	BH3-only	BH3-only	NNP
cord-259748-x7dq1sy4	227	14	family	family	NN
cord-259748-x7dq1sy4	227	15	,	,	,
cord-259748-x7dq1sy4	227	16	is	be	VBZ
cord-259748-x7dq1sy4	227	17	subsequently	subsequently	RB
cord-259748-x7dq1sy4	227	18	activated	activate	VBN
cord-259748-x7dq1sy4	227	19	in	in	IN
cord-259748-x7dq1sy4	227	20	a	a	DT
cord-259748-x7dq1sy4	227	21	RIP3	RIP3	NNP
cord-259748-x7dq1sy4	227	22	/	/	SYM
cord-259748-x7dq1sy4	227	23	MLKL	mlkl	NN
cord-259748-x7dq1sy4	227	24	-	-	HYPH
cord-259748-x7dq1sy4	227	25	dependent	dependent	JJ
cord-259748-x7dq1sy4	227	26	manner	manner	NN
cord-259748-x7dq1sy4	227	27	,	,	,
cord-259748-x7dq1sy4	227	28	which	which	WDT
cord-259748-x7dq1sy4	227	29	promotes	promote	VBZ
cord-259748-x7dq1sy4	227	30	leakage	leakage	NN
cord-259748-x7dq1sy4	227	31	of	of	IN
cord-259748-x7dq1sy4	227	32	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	227	33	by	by	IN
cord-259748-x7dq1sy4	227	34	MOMP	MOMP	NNP
cord-259748-x7dq1sy4	227	35	(	(	-LRB-
cord-259748-x7dq1sy4	227	36	119	119	CD
cord-259748-x7dq1sy4	227	37	,	,	,
cord-259748-x7dq1sy4	227	38	120	120	CD
cord-259748-x7dq1sy4	227	39	)	)	-RRB-
cord-259748-x7dq1sy4	227	40	.	.	.
cord-259748-x7dq1sy4	228	1	Activated	activate	VBN
cord-259748-x7dq1sy4	228	2	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	228	3	can	can	MD
cord-259748-x7dq1sy4	228	4	bind	bind	VB
cord-259748-x7dq1sy4	228	5	directly	directly	RB
cord-259748-x7dq1sy4	228	6	to	to	IN
cord-259748-x7dq1sy4	228	7	BAX	BAX	NNP
cord-259748-x7dq1sy4	228	8	to	to	TO
cord-259748-x7dq1sy4	228	9	form	form	VB
cord-259748-x7dq1sy4	228	10	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	228	11	/	/	SYM
cord-259748-x7dq1sy4	228	12	BAX	BAX	NNP
cord-259748-x7dq1sy4	228	13	complex	complex	NN
cord-259748-x7dq1sy4	228	14	and	and	CC
cord-259748-x7dq1sy4	228	15	induce	induce	VB
cord-259748-x7dq1sy4	228	16	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	228	17	(	(	-LRB-
cord-259748-x7dq1sy4	228	18	47	47	CD
cord-259748-x7dq1sy4	228	19	)	)	-RRB-
cord-259748-x7dq1sy4	228	20	.	.	.
cord-259748-x7dq1sy4	229	1	Excessive	excessive	JJ
cord-259748-x7dq1sy4	229	2	cGAS	cgas	JJ
cord-259748-x7dq1sy4	229	3	-	-	HYPH
cord-259748-x7dq1sy4	229	4	STING	sting	NN
cord-259748-x7dq1sy4	229	5	-	-	HYPH
cord-259748-x7dq1sy4	229	6	mediated	mediate	VBN
cord-259748-x7dq1sy4	229	7	autophagy	autophagy	NN
cord-259748-x7dq1sy4	229	8	signaling	signal	VBG
cord-259748-x7dq1sy4	229	9	can	can	MD
cord-259748-x7dq1sy4	229	10	cause	cause	VB
cord-259748-x7dq1sy4	229	11	"	"	``
cord-259748-x7dq1sy4	229	12	autophagic	autophagic	JJ
cord-259748-x7dq1sy4	229	13	cell	cell	NN
cord-259748-x7dq1sy4	229	14	death	death	NN
cord-259748-x7dq1sy4	229	15	"	"	''
cord-259748-x7dq1sy4	229	16	and	and	CC
cord-259748-x7dq1sy4	229	17	prevent	prevent	VB
cord-259748-x7dq1sy4	229	18	malignant	malignant	JJ
cord-259748-x7dq1sy4	229	19	transformation	transformation	NN
cord-259748-x7dq1sy4	229	20	of	of	IN
cord-259748-x7dq1sy4	229	21	cells	cell	NNS
cord-259748-x7dq1sy4	229	22	through	through	IN
cord-259748-x7dq1sy4	229	23	DNA	dna	NN
cord-259748-x7dq1sy4	229	24	damage	damage	NN
cord-259748-x7dq1sy4	229	25	(	(	-LRB-
cord-259748-x7dq1sy4	229	26	94	94	CD
cord-259748-x7dq1sy4	229	27	,	,	,
cord-259748-x7dq1sy4	229	28	121	121	CD
cord-259748-x7dq1sy4	229	29	)	)	-RRB-
cord-259748-x7dq1sy4	229	30	.	.	.
cord-259748-x7dq1sy4	230	1	STING	sting	VB
cord-259748-x7dq1sy4	230	2	trafficking	traffic	VBG
cord-259748-x7dq1sy4	230	3	to	to	IN
cord-259748-x7dq1sy4	230	4	the	the	DT
cord-259748-x7dq1sy4	230	5	lysosome	lysosome	NN
cord-259748-x7dq1sy4	230	6	can	can	MD
cord-259748-x7dq1sy4	230	7	broaden	broaden	VB
cord-259748-x7dq1sy4	230	8	permeabilization	permeabilization	NN
cord-259748-x7dq1sy4	230	9	of	of	IN
cord-259748-x7dq1sy4	230	10	the	the	DT
cord-259748-x7dq1sy4	230	11	lysosome	lysosome	NN
cord-259748-x7dq1sy4	230	12	membrane	membrane	NN
cord-259748-x7dq1sy4	230	13	,	,	,
cord-259748-x7dq1sy4	230	14	thereby	thereby	RB
cord-259748-x7dq1sy4	230	15	rupturing	rupture	VBG
cord-259748-x7dq1sy4	230	16	the	the	DT
cord-259748-x7dq1sy4	230	17	lysosome	lysosome	NN
cord-259748-x7dq1sy4	230	18	and	and	CC
cord-259748-x7dq1sy4	230	19	releasing	release	VBG
cord-259748-x7dq1sy4	230	20	its	-PRON-	PRP$
cord-259748-x7dq1sy4	230	21	contents	content	NNS
cord-259748-x7dq1sy4	230	22	,	,	,
cord-259748-x7dq1sy4	230	23	resulting	result	VBG
cord-259748-x7dq1sy4	230	24	in	in	IN
cord-259748-x7dq1sy4	230	25	"	"	``
cord-259748-x7dq1sy4	230	26	lysosomal	lysosomal	JJ
cord-259748-x7dq1sy4	230	27	cell	cell	NN
cord-259748-x7dq1sy4	230	28	death	death	NN
cord-259748-x7dq1sy4	230	29	(	(	-LRB-
cord-259748-x7dq1sy4	230	30	LCD	LCD	NNP
cord-259748-x7dq1sy4	230	31	)	)	-RRB-
cord-259748-x7dq1sy4	230	32	"	"	''
cord-259748-x7dq1sy4	230	33	.	.	.
cord-259748-x7dq1sy4	231	1	LCD	LCD	NNP
cord-259748-x7dq1sy4	231	2	further	further	RB
cord-259748-x7dq1sy4	231	3	triggers	trigger	VBZ
cord-259748-x7dq1sy4	231	4	K	k	NN
cord-259748-x7dq1sy4	231	5	+	+	CC
cord-259748-x7dq1sy4	231	6	efflux	efflux	NN
cord-259748-x7dq1sy4	231	7	and	and	CC
cord-259748-x7dq1sy4	231	8	NLRP3	nlrp3	NN
cord-259748-x7dq1sy4	231	9	activation	activation	NN
cord-259748-x7dq1sy4	231	10	,	,	,
cord-259748-x7dq1sy4	231	11	ultimately	ultimately	RB
cord-259748-x7dq1sy4	231	12	resulting	result	VBG
cord-259748-x7dq1sy4	231	13	in	in	IN
cord-259748-x7dq1sy4	231	14	pyroptosis	pyroptosis	NN
cord-259748-x7dq1sy4	231	15	(	(	-LRB-
cord-259748-x7dq1sy4	231	16	96	96	CD
cord-259748-x7dq1sy4	231	17	,	,	,
cord-259748-x7dq1sy4	231	18	101	101	CD
cord-259748-x7dq1sy4	231	19	)	)	-RRB-
cord-259748-x7dq1sy4	231	20	(	(	-LRB-
cord-259748-x7dq1sy4	231	21	Figure	Figure	NNP
cord-259748-x7dq1sy4	231	22	3D	3d	NN
cord-259748-x7dq1sy4	231	23	)	)	-RRB-
cord-259748-x7dq1sy4	231	24	.	.	.
cord-259748-x7dq1sy4	232	1	Moreover	moreover	RB
cord-259748-x7dq1sy4	232	2	,	,	,
cord-259748-x7dq1sy4	232	3	stimulating	stimulate	VBG
cord-259748-x7dq1sy4	232	4	STING	sting	NN
cord-259748-x7dq1sy4	232	5	-	-	HYPH
cord-259748-x7dq1sy4	232	6	dependent	dependent	JJ
cord-259748-x7dq1sy4	232	7	type	type	NN
cord-259748-x7dq1sy4	232	8	-	-	:
cord-259748-x7dq1sy4	232	9	I	-PRON-	PRP
cord-259748-x7dq1sy4	232	10	IFN	IFN	NNP
cord-259748-x7dq1sy4	232	11	and	and	CC
cord-259748-x7dq1sy4	232	12	TNFα	TNFα	NNP
cord-259748-x7dq1sy4	232	13	signals	signal	NNS
cord-259748-x7dq1sy4	232	14	simultaneously	simultaneously	RB
cord-259748-x7dq1sy4	232	15	can	can	MD
cord-259748-x7dq1sy4	232	16	lead	lead	VB
cord-259748-x7dq1sy4	232	17	to	to	IN
cord-259748-x7dq1sy4	232	18	necroptosis	necroptosis	NN
cord-259748-x7dq1sy4	232	19	of	of	IN
cord-259748-x7dq1sy4	232	20	tumor	tumor	NN
cord-259748-x7dq1sy4	232	21	cells	cell	NNS
cord-259748-x7dq1sy4	232	22	(	(	-LRB-
cord-259748-x7dq1sy4	232	23	122	122	CD
cord-259748-x7dq1sy4	232	24	,	,	,
cord-259748-x7dq1sy4	232	25	123	123	CD
cord-259748-x7dq1sy4	232	26	)	)	-RRB-
cord-259748-x7dq1sy4	232	27	.	.	.
cord-259748-x7dq1sy4	233	1	Cell	cell	NN
cord-259748-x7dq1sy4	233	2	senescence	senescence	NN
cord-259748-x7dq1sy4	233	3	is	be	VBZ
cord-259748-x7dq1sy4	233	4	recognized	recognize	VBN
cord-259748-x7dq1sy4	233	5	as	as	IN
cord-259748-x7dq1sy4	233	6	a	a	DT
cord-259748-x7dq1sy4	233	7	permanent	permanent	JJ
cord-259748-x7dq1sy4	233	8	arrest	arrest	NN
cord-259748-x7dq1sy4	233	9	of	of	IN
cord-259748-x7dq1sy4	233	10	the	the	DT
cord-259748-x7dq1sy4	233	11	cell	cell	NN
cord-259748-x7dq1sy4	233	12	cycle	cycle	NN
cord-259748-x7dq1sy4	233	13	,	,	,
cord-259748-x7dq1sy4	233	14	and	and	CC
cord-259748-x7dq1sy4	233	15	is	be	VBZ
cord-259748-x7dq1sy4	233	16	common	common	JJ
cord-259748-x7dq1sy4	233	17	in	in	IN
cord-259748-x7dq1sy4	233	18	aging	age	VBG
cord-259748-x7dq1sy4	233	19	,	,	,
cord-259748-x7dq1sy4	233	20	immunity	immunity	NN
cord-259748-x7dq1sy4	233	21	,	,	,
cord-259748-x7dq1sy4	233	22	ontogenesis	ontogenesis	NN
cord-259748-x7dq1sy4	233	23	and	and	CC
cord-259748-x7dq1sy4	233	24	infectious	infectious	JJ
cord-259748-x7dq1sy4	233	25	defense	defense	NN
cord-259748-x7dq1sy4	233	26	(	(	-LRB-
cord-259748-x7dq1sy4	233	27	124	124	CD
cord-259748-x7dq1sy4	233	28	)	)	-RRB-
cord-259748-x7dq1sy4	233	29	.	.	.
cord-259748-x7dq1sy4	234	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	234	2	lacks	lack	VBZ
cord-259748-x7dq1sy4	234	3	a	a	DT
cord-259748-x7dq1sy4	234	4	specific	specific	JJ
cord-259748-x7dq1sy4	234	5	biomarker	biomarker	NN
cord-259748-x7dq1sy4	234	6	but	but	CC
cord-259748-x7dq1sy4	234	7	can	can	MD
cord-259748-x7dq1sy4	234	8	be	be	VB
cord-259748-x7dq1sy4	234	9	identified	identify	VBN
cord-259748-x7dq1sy4	234	10	by	by	IN
cord-259748-x7dq1sy4	234	11	the	the	DT
cord-259748-x7dq1sy4	234	12	expression	expression	NN
cord-259748-x7dq1sy4	234	13	of	of	IN
cord-259748-x7dq1sy4	234	14	several	several	JJ
cord-259748-x7dq1sy4	234	15	antiproliferative	antiproliferative	JJ
cord-259748-x7dq1sy4	234	16	molecules	molecule	NNS
cord-259748-x7dq1sy4	234	17	(	(	-LRB-
cord-259748-x7dq1sy4	234	18	representatively	representatively	RB
cord-259748-x7dq1sy4	234	19	Rb	Rb	NNP
cord-259748-x7dq1sy4	234	20	-	-	HYPH
cord-259748-x7dq1sy4	234	21	p16	p16	NN
cord-259748-x7dq1sy4	234	22	andp53-p21	andp53-p21	.
cord-259748-x7dq1sy4	234	23	pathway	pathway	NN
cord-259748-x7dq1sy4	234	24	)	)	-RRB-
cord-259748-x7dq1sy4	234	25	(	(	-LRB-
cord-259748-x7dq1sy4	234	26	125	125	CD
cord-259748-x7dq1sy4	234	27	)	)	-RRB-
cord-259748-x7dq1sy4	234	28	.	.	.
cord-259748-x7dq1sy4	235	1	During	during	IN
cord-259748-x7dq1sy4	235	2	senescence	senescence	NN
cord-259748-x7dq1sy4	235	3	,	,	,
cord-259748-x7dq1sy4	235	4	changes	change	NNS
cord-259748-x7dq1sy4	235	5	in	in	IN
cord-259748-x7dq1sy4	235	6	the	the	DT
cord-259748-x7dq1sy4	235	7	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	235	8	structure	structure	NN
cord-259748-x7dq1sy4	235	9	and	and	CC
cord-259748-x7dq1sy4	235	10	loss	loss	NN
cord-259748-x7dq1sy4	235	11	of	of	IN
cord-259748-x7dq1sy4	235	12	the	the	DT
cord-259748-x7dq1sy4	235	13	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	235	14	lamina	lamina	NNP
cord-259748-x7dq1sy4	235	15	protein	protein	NN
cord-259748-x7dq1sy4	235	16	disrupt	disrupt	VB
cord-259748-x7dq1sy4	235	17	the	the	DT
cord-259748-x7dq1sy4	235	18	integrity	integrity	NN
cord-259748-x7dq1sy4	235	19	of	of	IN
cord-259748-x7dq1sy4	235	20	the	the	DT
cord-259748-x7dq1sy4	235	21	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	235	22	envelope	envelope	NN
cord-259748-x7dq1sy4	235	23	,	,	,
cord-259748-x7dq1sy4	235	24	leading	lead	VBG
cord-259748-x7dq1sy4	235	25	ultimately	ultimately	RB
cord-259748-x7dq1sy4	235	26	to	to	IN
cord-259748-x7dq1sy4	235	27	DNA	dna	NN
cord-259748-x7dq1sy4	235	28	damage	damage	NN
cord-259748-x7dq1sy4	235	29	and	and	CC
cord-259748-x7dq1sy4	235	30	cytoplasmic	cytoplasmic	JJ
cord-259748-x7dq1sy4	235	31	chromatin	chromatin	NN
cord-259748-x7dq1sy4	235	32	fragments	fragment	NNS
cord-259748-x7dq1sy4	235	33	(	(	-LRB-
cord-259748-x7dq1sy4	235	34	126	126	CD
cord-259748-x7dq1sy4	235	35	)	)	-RRB-
cord-259748-x7dq1sy4	235	36	.	.	.
cord-259748-x7dq1sy4	236	1	Cellular	cellular	JJ
cord-259748-x7dq1sy4	236	2	senescence	senescence	NN
cord-259748-x7dq1sy4	236	3	can	can	MD
cord-259748-x7dq1sy4	236	4	be	be	VB
cord-259748-x7dq1sy4	236	5	accelerated	accelerate	VBN
cord-259748-x7dq1sy4	236	6	by	by	IN
cord-259748-x7dq1sy4	236	7	accumulation	accumulation	NN
cord-259748-x7dq1sy4	236	8	of	of	IN
cord-259748-x7dq1sy4	236	9	cytoplasmic	cytoplasmic	JJ
cord-259748-x7dq1sy4	236	10	chromatin	chromatin	NN
cord-259748-x7dq1sy4	236	11	in	in	IN
cord-259748-x7dq1sy4	236	12	turn	turn	NN
cord-259748-x7dq1sy4	236	13	(	(	-LRB-
cord-259748-x7dq1sy4	236	14	127	127	CD
cord-259748-x7dq1sy4	236	15	)	)	-RRB-
cord-259748-x7dq1sy4	236	16	.	.	.
cord-259748-x7dq1sy4	237	1	These	these	DT
cord-259748-x7dq1sy4	237	2	senescent	senescent	JJ
cord-259748-x7dq1sy4	237	3	cells	cell	NNS
cord-259748-x7dq1sy4	237	4	produce	produce	VBP
cord-259748-x7dq1sy4	237	5	the	the	DT
cord-259748-x7dq1sy4	237	6	senescence	senescence	NN
cord-259748-x7dq1sy4	237	7	-	-	HYPH
cord-259748-x7dq1sy4	237	8	associated	associate	VBN
cord-259748-x7dq1sy4	237	9	secretory	secretory	JJ
cord-259748-x7dq1sy4	237	10	phenotype	phenotype	NN
cord-259748-x7dq1sy4	237	11	(	(	-LRB-
cord-259748-x7dq1sy4	237	12	SASP	SASP	NNP
cord-259748-x7dq1sy4	237	13	)	)	-RRB-
cord-259748-x7dq1sy4	237	14	,	,	,
cord-259748-x7dq1sy4	237	15	which	which	WDT
cord-259748-x7dq1sy4	237	16	shapes	shape	VBZ
cord-259748-x7dq1sy4	237	17	an	an	DT
cord-259748-x7dq1sy4	237	18	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	237	19	microenvironment	microenvironment	NN
cord-259748-x7dq1sy4	237	20	(	(	-LRB-
cord-259748-x7dq1sy4	237	21	128	128	CD
cord-259748-x7dq1sy4	237	22	)	)	-RRB-
cord-259748-x7dq1sy4	237	23	.	.	.
cord-259748-x7dq1sy4	238	1	The	the	DT
cord-259748-x7dq1sy4	238	2	cGAS	cgas	JJ
cord-259748-x7dq1sy4	238	3	-	-	HYPH
cord-259748-x7dq1sy4	238	4	STING	sting	NN
cord-259748-x7dq1sy4	238	5	pathway	pathway	NN
cord-259748-x7dq1sy4	238	6	has	have	VBZ
cord-259748-x7dq1sy4	238	7	been	be	VBN
cord-259748-x7dq1sy4	238	8	reported	report	VBN
cord-259748-x7dq1sy4	238	9	to	to	TO
cord-259748-x7dq1sy4	238	10	be	be	VB
cord-259748-x7dq1sy4	238	11	involved	involve	VBN
cord-259748-x7dq1sy4	238	12	in	in	IN
cord-259748-x7dq1sy4	238	13	the	the	DT
cord-259748-x7dq1sy4	238	14	recognition	recognition	NN
cord-259748-x7dq1sy4	238	15	of	of	IN
cord-259748-x7dq1sy4	238	16	cytoplasmic	cytoplasmic	JJ
cord-259748-x7dq1sy4	238	17	chromatin	chromatin	NN
cord-259748-x7dq1sy4	238	18	fragments	fragment	NNS
cord-259748-x7dq1sy4	238	19	from	from	IN
cord-259748-x7dq1sy4	238	20	senescence	senescence	NN
cord-259748-x7dq1sy4	238	21	-	-	HYPH
cord-259748-x7dq1sy4	238	22	related	relate	VBN
cord-259748-x7dq1sy4	238	23	DNA	dna	NN
cord-259748-x7dq1sy4	238	24	damage	damage	NN
cord-259748-x7dq1sy4	238	25	,	,	,
cord-259748-x7dq1sy4	238	26	and	and	CC
cord-259748-x7dq1sy4	238	27	mediate	mediate	VB
cord-259748-x7dq1sy4	238	28	the	the	DT
cord-259748-x7dq1sy4	238	29	expression	expression	NN
cord-259748-x7dq1sy4	238	30	of	of	IN
cord-259748-x7dq1sy4	238	31	SASP	SASP	NNP
cord-259748-x7dq1sy4	238	32	genes	gene	NNS
cord-259748-x7dq1sy4	238	33	(	(	-LRB-
cord-259748-x7dq1sy4	238	34	129	129	CD
cord-259748-x7dq1sy4	238	35	)	)	-RRB-
cord-259748-x7dq1sy4	238	36	(	(	-LRB-
cord-259748-x7dq1sy4	238	37	130	130	CD
cord-259748-x7dq1sy4	238	38	)	)	-RRB-
cord-259748-x7dq1sy4	238	39	(	(	-LRB-
cord-259748-x7dq1sy4	238	40	131	131	CD
cord-259748-x7dq1sy4	238	41	)	)	-RRB-
cord-259748-x7dq1sy4	238	42	(	(	-LRB-
cord-259748-x7dq1sy4	238	43	132	132	CD
cord-259748-x7dq1sy4	238	44	)	)	-RRB-
cord-259748-x7dq1sy4	238	45	.	.	.
cord-259748-x7dq1sy4	239	1	Along	along	IN
cord-259748-x7dq1sy4	239	2	with	with	IN
cord-259748-x7dq1sy4	239	3	these	these	DT
cord-259748-x7dq1sy4	239	4	actions	action	NNS
cord-259748-x7dq1sy4	239	5	,	,	,
cord-259748-x7dq1sy4	239	6	the	the	DT
cord-259748-x7dq1sy4	239	7	expression	expression	NN
cord-259748-x7dq1sy4	239	8	of	of	IN
cord-259748-x7dq1sy4	239	9	TREX1	TREX1	NNP
cord-259748-x7dq1sy4	239	10	and	and	CC
cord-259748-x7dq1sy4	239	11	DNaseII	dnaseii	NN
cord-259748-x7dq1sy4	239	12	is	be	VBZ
cord-259748-x7dq1sy4	239	13	inhibited	inhibit	VBN
cord-259748-x7dq1sy4	239	14	by	by	IN
cord-259748-x7dq1sy4	239	15	DNA	dna	NN
cord-259748-x7dq1sy4	239	16	damage	damage	NN
cord-259748-x7dq1sy4	239	17	through	through	IN
cord-259748-x7dq1sy4	239	18	the	the	DT
cord-259748-x7dq1sy4	239	19	inhibition	inhibition	NN
cord-259748-x7dq1sy4	239	20	of	of	IN
cord-259748-x7dq1sy4	239	21	E2F	E2F	NNP
cord-259748-x7dq1sy4	239	22	/	/	SYM
cord-259748-x7dq1sy4	239	23	DP	DP	NNP
cord-259748-x7dq1sy4	239	24	(	(	-LRB-
cord-259748-x7dq1sy4	239	25	a	a	DT
cord-259748-x7dq1sy4	239	26	potential	potential	JJ
cord-259748-x7dq1sy4	239	27	transcription	transcription	NN
cord-259748-x7dq1sy4	239	28	factor	factor	NN
cord-259748-x7dq1sy4	239	29	of	of	IN
cord-259748-x7dq1sy4	239	30	TREX1	trex1	NN
cord-259748-x7dq1sy4	239	31	and	and	CC
cord-259748-x7dq1sy4	239	32	DNaseII	DNaseII	NNP
cord-259748-x7dq1sy4	239	33	)	)	-RRB-
cord-259748-x7dq1sy4	239	34	(	(	-LRB-
cord-259748-x7dq1sy4	239	35	130	130	CD
cord-259748-x7dq1sy4	239	36	)	)	-RRB-
cord-259748-x7dq1sy4	239	37	.	.	.
cord-259748-x7dq1sy4	240	1	For	for	IN
cord-259748-x7dq1sy4	240	2	hematopoietic	hematopoietic	JJ
cord-259748-x7dq1sy4	240	3	stem	stem	NN
cord-259748-x7dq1sy4	240	4	cells	cell	NNS
cord-259748-x7dq1sy4	240	5	(	(	-LRB-
cord-259748-x7dq1sy4	240	6	HSCs	HSCs	NNP
cord-259748-x7dq1sy4	240	7	)	)	-RRB-
cord-259748-x7dq1sy4	240	8	,	,	,
cord-259748-x7dq1sy4	240	9	DNA	dna	NN
cord-259748-x7dq1sy4	240	10	damage	damage	NN
cord-259748-x7dq1sy4	240	11	can	can	MD
cord-259748-x7dq1sy4	240	12	promote	promote	VB
cord-259748-x7dq1sy4	240	13	excessive	excessive	JJ
cord-259748-x7dq1sy4	240	14	secretion	secretion	NN
cord-259748-x7dq1sy4	240	15	of	of	IN
cord-259748-x7dq1sy4	240	16	type	type	NN
cord-259748-x7dq1sy4	240	17	-	-	:
cord-259748-x7dq1sy4	240	18	I	-PRON-	PRP
cord-259748-x7dq1sy4	240	19	IFN	IFN	NNP
cord-259748-x7dq1sy4	240	20	in	in	IN
cord-259748-x7dq1sy4	240	21	the	the	DT
cord-259748-x7dq1sy4	240	22	HSC	HSC	NNP
cord-259748-x7dq1sy4	240	23	niche	niche	NN
cord-259748-x7dq1sy4	240	24	and	and	CC
cord-259748-x7dq1sy4	240	25	activate	activate	VB
cord-259748-x7dq1sy4	240	26	p53	p53	NN
cord-259748-x7dq1sy4	240	27	pathway	pathway	NN
cord-259748-x7dq1sy4	240	28	,	,	,
cord-259748-x7dq1sy4	240	29	both	both	DT
cord-259748-x7dq1sy4	240	30	of	of	IN
cord-259748-x7dq1sy4	240	31	which	which	WDT
cord-259748-x7dq1sy4	240	32	can	can	MD
cord-259748-x7dq1sy4	240	33	lead	lead	VB
cord-259748-x7dq1sy4	240	34	to	to	IN
cord-259748-x7dq1sy4	240	35	long	long	JJ
cord-259748-x7dq1sy4	240	36	-	-	HYPH
cord-259748-x7dq1sy4	240	37	term	term	NN
cord-259748-x7dq1sy4	240	38	senescence	senescence	NN
cord-259748-x7dq1sy4	240	39	and	and	CC
cord-259748-x7dq1sy4	240	40	exhaustion	exhaustion	NN
cord-259748-x7dq1sy4	240	41	of	of	IN
cord-259748-x7dq1sy4	240	42	HSCs	hscs	NN
cord-259748-x7dq1sy4	240	43	(	(	-LRB-
cord-259748-x7dq1sy4	240	44	133	133	CD
cord-259748-x7dq1sy4	240	45	,	,	,
cord-259748-x7dq1sy4	240	46	134	134	CD
cord-259748-x7dq1sy4	240	47	)	)	-RRB-
cord-259748-x7dq1sy4	240	48	.	.	.
cord-259748-x7dq1sy4	241	1	HSCs	hsc	NNS
cord-259748-x7dq1sy4	241	2	expressing	express	VBG
cord-259748-x7dq1sy4	241	3	a	a	DT
cord-259748-x7dq1sy4	241	4	circular	circular	JJ
cord-259748-x7dq1sy4	241	5	RNA	RNA	NNP
cord-259748-x7dq1sy4	241	6	named	name	VBN
cord-259748-x7dq1sy4	241	7	"	"	``
cord-259748-x7dq1sy4	241	8	cia	cia	NNP
cord-259748-x7dq1sy4	241	9	-	-	HYPH
cord-259748-x7dq1sy4	241	10	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	241	11	"	"	''
cord-259748-x7dq1sy4	241	12	in	in	IN
cord-259748-x7dq1sy4	241	13	the	the	DT
cord-259748-x7dq1sy4	241	14	nucleus	nucleus	NN
cord-259748-x7dq1sy4	241	15	,	,	,
cord-259748-x7dq1sy4	241	16	however	however	RB
cord-259748-x7dq1sy4	241	17	,	,	,
cord-259748-x7dq1sy4	241	18	are	be	VBP
cord-259748-x7dq1sy4	241	19	protected	protect	VBN
cord-259748-x7dq1sy4	241	20	from	from	IN
cord-259748-x7dq1sy4	241	21	this	this	DT
cord-259748-x7dq1sy4	241	22	exhaustion	exhaustion	NN
cord-259748-x7dq1sy4	241	23	as	as	IN
cord-259748-x7dq1sy4	241	24	a	a	DT
cord-259748-x7dq1sy4	241	25	result	result	NN
cord-259748-x7dq1sy4	241	26	of	of	IN
cord-259748-x7dq1sy4	241	27	cia	cia	NNP
cord-259748-x7dq1sy4	241	28	-	-	HYPH
cord-259748-x7dq1sy4	241	29	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	241	30	having	have	VBG
cord-259748-x7dq1sy4	241	31	stronger	strong	JJR
cord-259748-x7dq1sy4	241	32	affinity	affinity	NN
cord-259748-x7dq1sy4	241	33	than	than	IN
cord-259748-x7dq1sy4	241	34	that	that	DT
cord-259748-x7dq1sy4	241	35	of	of	IN
cord-259748-x7dq1sy4	241	36	self	self	NN
cord-259748-x7dq1sy4	241	37	-	-	HYPH
cord-259748-x7dq1sy4	241	38	DNA	dna	NN
cord-259748-x7dq1sy4	241	39	,	,	,
cord-259748-x7dq1sy4	241	40	which	which	WDT
cord-259748-x7dq1sy4	241	41	prevents	prevent	VBZ
cord-259748-x7dq1sy4	241	42	it	-PRON-	PRP
cord-259748-x7dq1sy4	241	43	from	from	IN
cord-259748-x7dq1sy4	241	44	being	be	VBG
cord-259748-x7dq1sy4	241	45	sensed	sense	VBN
cord-259748-x7dq1sy4	241	46	(	(	-LRB-
cord-259748-x7dq1sy4	241	47	135	135	CD
cord-259748-x7dq1sy4	241	48	)	)	-RRB-
cord-259748-x7dq1sy4	241	49	.	.	.
cord-259748-x7dq1sy4	242	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	242	2	implied	imply	VBD
cord-259748-x7dq1sy4	242	3	a	a	DT
cord-259748-x7dq1sy4	242	4	novel	novel	JJ
cord-259748-x7dq1sy4	242	5	target	target	NN
cord-259748-x7dq1sy4	242	6	to	to	TO
cord-259748-x7dq1sy4	242	7	manipulate	manipulate	VB
cord-259748-x7dq1sy4	242	8	the	the	DT
cord-259748-x7dq1sy4	242	9	immune	immune	JJ
cord-259748-x7dq1sy4	242	10	environment	environment	NN
cord-259748-x7dq1sy4	242	11	in	in	IN
cord-259748-x7dq1sy4	242	12	bone	bone	NN
cord-259748-x7dq1sy4	242	13	marrow	marrow	NN
cord-259748-x7dq1sy4	242	14	and	and	CC
cord-259748-x7dq1sy4	242	15	help	help	NN
cord-259748-x7dq1sy4	242	16	for	for	IN
cord-259748-x7dq1sy4	242	17	finding	find	VBG
cord-259748-x7dq1sy4	242	18	treatment	treatment	NN
cord-259748-x7dq1sy4	242	19	approaches	approach	NNS
cord-259748-x7dq1sy4	242	20	for	for	IN
cord-259748-x7dq1sy4	242	21	hematopoiesis	hematopoiesis	NN
cord-259748-x7dq1sy4	242	22	-	-	HYPH
cord-259748-x7dq1sy4	242	23	based	base	VBN
cord-259748-x7dq1sy4	242	24	diseases	disease	NNS
cord-259748-x7dq1sy4	242	25	,	,	,
cord-259748-x7dq1sy4	242	26	such	such	JJ
cord-259748-x7dq1sy4	242	27	as	as	IN
cord-259748-x7dq1sy4	242	28	aplastic	aplastic	JJ
cord-259748-x7dq1sy4	242	29	anemia	anemia	NN
cord-259748-x7dq1sy4	242	30	.	.	.
cord-259748-x7dq1sy4	243	1	Utilizing	utilize	VBG
cord-259748-x7dq1sy4	243	2	cellular	cellular	JJ
cord-259748-x7dq1sy4	243	3	senescence	senescence	NN
cord-259748-x7dq1sy4	243	4	to	to	TO
cord-259748-x7dq1sy4	243	5	restrain	restrain	VB
cord-259748-x7dq1sy4	243	6	tumor	tumor	NN
cord-259748-x7dq1sy4	243	7	growth	growth	NN
cord-259748-x7dq1sy4	243	8	is	be	VBZ
cord-259748-x7dq1sy4	243	9	discussed	discuss	VBN
cord-259748-x7dq1sy4	243	10	below	below	RB
cord-259748-x7dq1sy4	243	11	.	.	.
cord-259748-x7dq1sy4	244	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	244	2	-	-	HYPH
cord-259748-x7dq1sy4	244	3	STING	sting	NN
cord-259748-x7dq1sy4	244	4	signaling	signaling	NN
cord-259748-x7dq1sy4	244	5	has	have	VBZ
cord-259748-x7dq1sy4	244	6	an	an	DT
cord-259748-x7dq1sy4	244	7	essential	essential	JJ
cord-259748-x7dq1sy4	244	8	role	role	NN
cord-259748-x7dq1sy4	244	9	in	in	IN
cord-259748-x7dq1sy4	244	10	defense	defense	NN
cord-259748-x7dq1sy4	244	11	against	against	IN
cord-259748-x7dq1sy4	244	12	a	a	DT
cord-259748-x7dq1sy4	244	13	broad	broad	JJ
cord-259748-x7dq1sy4	244	14	spectrum	spectrum	NN
cord-259748-x7dq1sy4	244	15	of	of	IN
cord-259748-x7dq1sy4	244	16	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	244	17	DNA	DNA	NNP
cord-259748-x7dq1sy4	244	18	and	and	CC
cord-259748-x7dq1sy4	244	19	RNA	RNA	NNP
cord-259748-x7dq1sy4	244	20	viruses	virus	NNS
cord-259748-x7dq1sy4	244	21	(	(	-LRB-
cord-259748-x7dq1sy4	244	22	9	9	CD
cord-259748-x7dq1sy4	244	23	,	,	,
cord-259748-x7dq1sy4	244	24	26	26	CD
cord-259748-x7dq1sy4	244	25	,	,	,
cord-259748-x7dq1sy4	244	26	50	50	CD
cord-259748-x7dq1sy4	244	27	)	)	-RRB-
cord-259748-x7dq1sy4	244	28	.	.	.
cord-259748-x7dq1sy4	245	1	HIV	HIV	NNP
cord-259748-x7dq1sy4	245	2	is	be	VBZ
cord-259748-x7dq1sy4	245	3	a	a	DT
cord-259748-x7dq1sy4	245	4	typical	typical	JJ
cord-259748-x7dq1sy4	245	5	RNA	RNA	NNP
cord-259748-x7dq1sy4	245	6	retrovirus	retrovirus	NN
cord-259748-x7dq1sy4	245	7	:	:	:
cord-259748-x7dq1sy4	245	8	there	there	EX
cord-259748-x7dq1sy4	245	9	is	be	VBZ
cord-259748-x7dq1sy4	245	10	neither	neither	DT
cord-259748-x7dq1sy4	245	11	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	245	12	in	in	IN
cord-259748-x7dq1sy4	245	13	its	-PRON-	PRP$
cord-259748-x7dq1sy4	245	14	genome	genome	NN
cord-259748-x7dq1sy4	245	15	,	,	,
cord-259748-x7dq1sy4	245	16	nor	nor	CC
cord-259748-x7dq1sy4	245	17	production	production	NN
cord-259748-x7dq1sy4	245	18	of	of	IN
cord-259748-x7dq1sy4	245	19	nucleic	nucleic	JJ
cord-259748-x7dq1sy4	245	20	acids	acid	NNS
cord-259748-x7dq1sy4	245	21	(	(	-LRB-
cord-259748-x7dq1sy4	245	22	50	50	CD
cord-259748-x7dq1sy4	245	23	)	)	-RRB-
cord-259748-x7dq1sy4	245	24	.	.	.
cord-259748-x7dq1sy4	246	1	Nevertheless	nevertheless	RB
cord-259748-x7dq1sy4	246	2	,	,	,
cord-259748-x7dq1sy4	246	3	cGAS	cgas	NN
cord-259748-x7dq1sy4	246	4	can	can	MD
cord-259748-x7dq1sy4	246	5	detect	detect	VB
cord-259748-x7dq1sy4	246	6	the	the	DT
cord-259748-x7dq1sy4	246	7	presence	presence	NN
cord-259748-x7dq1sy4	246	8	of	of	IN
cord-259748-x7dq1sy4	246	9	HIV	HIV	NNP
cord-259748-x7dq1sy4	246	10	.	.	.
cord-259748-x7dq1sy4	247	1	RNA	RNA	NNP
cord-259748-x7dq1sy4	247	2	:	:	:
cord-259748-x7dq1sy4	248	1	DNA	dna	NN
cord-259748-x7dq1sy4	248	2	hybrids	hybrid	NNS
cord-259748-x7dq1sy4	248	3	synthesized	synthesize	VBN
cord-259748-x7dq1sy4	248	4	during	during	IN
cord-259748-x7dq1sy4	248	5	reverse	reverse	JJ
cord-259748-x7dq1sy4	248	6	transcription	transcription	NN
cord-259748-x7dq1sy4	248	7	that	that	WDT
cord-259748-x7dq1sy4	248	8	can	can	MD
cord-259748-x7dq1sy4	248	9	be	be	VB
cord-259748-x7dq1sy4	248	10	sensed	sense	VBN
cord-259748-x7dq1sy4	248	11	by	by	IN
cord-259748-x7dq1sy4	248	12	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	248	13	explain	explain	VB
cord-259748-x7dq1sy4	248	14	(	(	-LRB-
cord-259748-x7dq1sy4	248	15	at	at	IN
cord-259748-x7dq1sy4	248	16	least	least	JJS
cord-259748-x7dq1sy4	248	17	in	in	IN
cord-259748-x7dq1sy4	248	18	part	part	NN
cord-259748-x7dq1sy4	248	19	)	)	-RRB-
cord-259748-x7dq1sy4	249	1	this	this	DT
cord-259748-x7dq1sy4	249	2	phenomenon	phenomenon	NN
cord-259748-x7dq1sy4	249	3	(	(	-LRB-
cord-259748-x7dq1sy4	249	4	14	14	CD
cord-259748-x7dq1sy4	249	5	)	)	-RRB-
cord-259748-x7dq1sy4	249	6	.	.	.
cord-259748-x7dq1sy4	250	1	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	250	2	may	may	MD
cord-259748-x7dq1sy4	250	3	be	be	VB
cord-259748-x7dq1sy4	250	4	triggered	trigger	VBN
cord-259748-x7dq1sy4	250	5	by	by	IN
cord-259748-x7dq1sy4	250	6	endogenous	endogenous	JJ
cord-259748-x7dq1sy4	250	7	DNA	dna	NN
cord-259748-x7dq1sy4	250	8	broken	break	VBN
cord-259748-x7dq1sy4	250	9	and	and	CC
cord-259748-x7dq1sy4	250	10	released	release	VBN
cord-259748-x7dq1sy4	250	11	during	during	IN
cord-259748-x7dq1sy4	250	12	HIV	HIV	NNP
cord-259748-x7dq1sy4	250	13	infection	infection	NN
cord-259748-x7dq1sy4	250	14	as	as	RB
cord-259748-x7dq1sy4	250	15	well	well	RB
cord-259748-x7dq1sy4	250	16	theoretically	theoretically	RB
cord-259748-x7dq1sy4	250	17	.	.	.
cord-259748-x7dq1sy4	251	1	However	however	RB
cord-259748-x7dq1sy4	251	2	,	,	,
cord-259748-x7dq1sy4	251	3	some	some	DT
cord-259748-x7dq1sy4	251	4	studies	study	NNS
cord-259748-x7dq1sy4	251	5	found	find	VBD
cord-259748-x7dq1sy4	251	6	the	the	DT
cord-259748-x7dq1sy4	251	7	new	new	JJ
cord-259748-x7dq1sy4	251	8	mechanisms	mechanism	NNS
cord-259748-x7dq1sy4	251	9	.	.	.
cord-259748-x7dq1sy4	252	1	The	the	DT
cord-259748-x7dq1sy4	252	2	early	early	JJ
cord-259748-x7dq1sy4	252	3	reverse	reverse	JJ
cord-259748-x7dq1sy4	252	4	-	-	HYPH
cord-259748-x7dq1sy4	252	5	transcription	transcription	NN
cord-259748-x7dq1sy4	252	6	production	production	NN
cord-259748-x7dq1sy4	252	7	of	of	IN
cord-259748-x7dq1sy4	252	8	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	252	9	can	can	MD
cord-259748-x7dq1sy4	252	10	flank	flank	VB
cord-259748-x7dq1sy4	252	11	short	short	JJ
cord-259748-x7dq1sy4	252	12	stem	stem	NN
cord-259748-x7dq1sy4	252	13	loops	loop	NNS
cord-259748-x7dq1sy4	252	14	with	with	IN
cord-259748-x7dq1sy4	252	15	paired	pair	VBN
cord-259748-x7dq1sy4	252	16	base	base	NN
cord-259748-x7dq1sy4	252	17	,	,	,
cord-259748-x7dq1sy4	252	18	which	which	WDT
cord-259748-x7dq1sy4	252	19	lead	lead	VBP
cord-259748-x7dq1sy4	252	20	to	to	IN
cord-259748-x7dq1sy4	252	21	the	the	DT
cord-259748-x7dq1sy4	252	22	production	production	NN
cord-259748-x7dq1sy4	252	23	of	of	IN
cord-259748-x7dq1sy4	252	24	Y	y	NN
cord-259748-x7dq1sy4	252	25	-	-	HYPH
cord-259748-x7dq1sy4	252	26	type	type	NN
cord-259748-x7dq1sy4	252	27	DNA	dna	NN
cord-259748-x7dq1sy4	252	28	containing	contain	VBG
cord-259748-x7dq1sy4	252	29	unpaired	unpaired	JJ
cord-259748-x7dq1sy4	252	30	guanosines	guanosine	NNS
cord-259748-x7dq1sy4	252	31	that	that	WDT
cord-259748-x7dq1sy4	252	32	can	can	MD
cord-259748-x7dq1sy4	252	33	activate	activate	VB
cord-259748-x7dq1sy4	252	34	cGAS	cgas	NN
cord-259748-x7dq1sy4	252	35	well	well	NN
cord-259748-x7dq1sy4	252	36	(	(	-LRB-
cord-259748-x7dq1sy4	252	37	15	15	CD
cord-259748-x7dq1sy4	252	38	)	)	-RRB-
cord-259748-x7dq1sy4	252	39	.	.	.
cord-259748-x7dq1sy4	253	1	Moreover	moreover	RB
cord-259748-x7dq1sy4	253	2	,	,	,
cord-259748-x7dq1sy4	253	3	nucleolus	nucleolus	NN
cord-259748-x7dq1sy4	253	4	protein	protein	NN
cord-259748-x7dq1sy4	253	5	non	non	NNP
cord-259748-x7dq1sy4	253	6	-	-	JJ
cord-259748-x7dq1sy4	253	7	POU	POU	NNP
cord-259748-x7dq1sy4	253	8	domain	domain	NN
cord-259748-x7dq1sy4	253	9	-	-	HYPH
cord-259748-x7dq1sy4	253	10	containing	contain	VBG
cord-259748-x7dq1sy4	253	11	octamer	octamer	NN
cord-259748-x7dq1sy4	253	12	-	-	HYPH
cord-259748-x7dq1sy4	253	13	binding	bind	VBG
cord-259748-x7dq1sy4	253	14	protein	protein	NN
cord-259748-x7dq1sy4	253	15	(	(	-LRB-
cord-259748-x7dq1sy4	253	16	NONO	NONO	NNP
cord-259748-x7dq1sy4	253	17	)	)	-RRB-
cord-259748-x7dq1sy4	253	18	,	,	,
cord-259748-x7dq1sy4	253	19	as	as	IN
cord-259748-x7dq1sy4	253	20	a	a	DT
cord-259748-x7dq1sy4	253	21	sensor	sensor	NN
cord-259748-x7dq1sy4	253	22	of	of	IN
cord-259748-x7dq1sy4	253	23	capsid	capsid	NN
cord-259748-x7dq1sy4	253	24	components	component	NNS
cord-259748-x7dq1sy4	253	25	of	of	IN
cord-259748-x7dq1sy4	253	26	HIV	HIV	NNP
cord-259748-x7dq1sy4	253	27	,	,	,
cord-259748-x7dq1sy4	253	28	can	can	MD
cord-259748-x7dq1sy4	253	29	help	help	VB
cord-259748-x7dq1sy4	253	30	cGAS	cgas	VB
cord-259748-x7dq1sy4	253	31	to	to	TO
cord-259748-x7dq1sy4	253	32	be	be	VB
cord-259748-x7dq1sy4	253	33	translocated	translocate	VBN
cord-259748-x7dq1sy4	253	34	to	to	IN
cord-259748-x7dq1sy4	253	35	the	the	DT
cord-259748-x7dq1sy4	253	36	nucleus	nucleus	NN
cord-259748-x7dq1sy4	253	37	and	and	CC
cord-259748-x7dq1sy4	253	38	assist	assist	VB
cord-259748-x7dq1sy4	253	39	cGAS	cga	VBG
cord-259748-x7dq1sy4	253	40	to	to	TO
cord-259748-x7dq1sy4	253	41	sense	sense	VB
cord-259748-x7dq1sy4	253	42	HIV	HIV	NNP
cord-259748-x7dq1sy4	253	43	DNA	DNA	NNP
cord-259748-x7dq1sy4	253	44	accompanied	accompany	VBN
cord-259748-x7dq1sy4	253	45	by	by	IN
cord-259748-x7dq1sy4	253	46	polyglutamine	polyglutamine	JJ
cord-259748-x7dq1sy4	253	47	-	-	HYPH
cord-259748-x7dq1sy4	253	48	binding	bind	VBG
cord-259748-x7dq1sy4	253	49	protein	protein	NN
cord-259748-x7dq1sy4	253	50	1	1	CD
cord-259748-x7dq1sy4	253	51	(	(	-LRB-
cord-259748-x7dq1sy4	253	52	PQBP1	PQBP1	NNS
cord-259748-x7dq1sy4	253	53	)	)	-RRB-
cord-259748-x7dq1sy4	254	1	(	(	-LRB-
cord-259748-x7dq1sy4	254	2	136	136	CD
cord-259748-x7dq1sy4	254	3	,	,	,
cord-259748-x7dq1sy4	254	4	137	137	CD
cord-259748-x7dq1sy4	254	5	)	)	-RRB-
cord-259748-x7dq1sy4	254	6	.	.	.
cord-259748-x7dq1sy4	255	1	The	the	DT
cord-259748-x7dq1sy4	255	2	assistance	assistance	NN
cord-259748-x7dq1sy4	255	3	proffered	proffer	VBN
cord-259748-x7dq1sy4	255	4	by	by	IN
cord-259748-x7dq1sy4	255	5	NONO	NONO	NNP
cord-259748-x7dq1sy4	255	6	in	in	IN
cord-259748-x7dq1sy4	255	7	assisting	assist	VBG
cord-259748-x7dq1sy4	255	8	cGAS	cgas	NN
cord-259748-x7dq1sy4	255	9	to	to	TO
cord-259748-x7dq1sy4	255	10	sense	sense	VB
cord-259748-x7dq1sy4	255	11	DNA	DNA	NNP
cord-259748-x7dq1sy4	255	12	is	be	VBZ
cord-259748-x7dq1sy4	255	13	also	also	RB
cord-259748-x7dq1sy4	255	14	associated	associate	VBN
cord-259748-x7dq1sy4	255	15	with	with	IN
cord-259748-x7dq1sy4	255	16	its	-PRON-	PRP$
cord-259748-x7dq1sy4	255	17	role	role	NN
cord-259748-x7dq1sy4	255	18	in	in	IN
cord-259748-x7dq1sy4	255	19	constructing	construct	VBG
cord-259748-x7dq1sy4	255	20	a	a	DT
cord-259748-x7dq1sy4	255	21	ribonuclear	ribonuclear	JJ
cord-259748-x7dq1sy4	255	22	complex	complex	NN
cord-259748-x7dq1sy4	255	23	with	with	IN
cord-259748-x7dq1sy4	255	24	DNA	dna	NN
cord-259748-x7dq1sy4	255	25	-	-	HYPH
cord-259748-x7dq1sy4	255	26	dependent	dependent	JJ
cord-259748-x7dq1sy4	255	27	protein	protein	NN
cord-259748-x7dq1sy4	255	28	kinase	kinase	NN
cord-259748-x7dq1sy4	255	29	(	(	-LRB-
cord-259748-x7dq1sy4	255	30	DNA	dna	NN
cord-259748-x7dq1sy4	255	31	-	-	HYPH
cord-259748-x7dq1sy4	255	32	PK	PK	NNP
cord-259748-x7dq1sy4	255	33	)	)	-RRB-
cord-259748-x7dq1sy4	255	34	subunits	subunit	NNS
cord-259748-x7dq1sy4	255	35	around	around	IN
cord-259748-x7dq1sy4	255	36	hexamethylene	hexamethylene	NNP
cord-259748-x7dq1sy4	255	37	bisacetamide	bisacetamide	JJ
cord-259748-x7dq1sy4	255	38	-	-	HYPH
cord-259748-x7dq1sy4	255	39	inducible	inducible	JJ
cord-259748-x7dq1sy4	255	40	protein1	protein1	NN
cord-259748-x7dq1sy4	255	41	(	(	-LRB-
cord-259748-x7dq1sy4	255	42	HEXIM1	HEXIM1	NNP
cord-259748-x7dq1sy4	255	43	)	)	-RRB-
cord-259748-x7dq1sy4	255	44	,	,	,
cord-259748-x7dq1sy4	255	45	termed	term	VBN
cord-259748-x7dq1sy4	255	46	as	as	IN
cord-259748-x7dq1sy4	255	47	"	"	``
cord-259748-x7dq1sy4	255	48	HEXIM1-DNA	HEXIM1-DNA	NNP
cord-259748-x7dq1sy4	255	49	-	-	HYPH
cord-259748-x7dq1sy4	255	50	PK	PK	NNP
cord-259748-x7dq1sy4	255	51	-paraspeckle	-paraspeckle	HYPH
cord-259748-x7dq1sy4	255	52	components	component	NNS
cord-259748-x7dq1sy4	255	53	-	-	HYPH
cord-259748-x7dq1sy4	255	54	ribonuclear	ribonuclear	NN
cord-259748-x7dq1sy4	255	55	protein	protein	NN
cord-259748-x7dq1sy4	255	56	complex	complex	NN
cord-259748-x7dq1sy4	255	57	(	(	-LRB-
cord-259748-x7dq1sy4	255	58	HDP	HDP	NNP
cord-259748-x7dq1sy4	255	59	-	-	HYPH
cord-259748-x7dq1sy4	255	60	RNP	RNP	NNP
cord-259748-x7dq1sy4	255	61	)	)	-RRB-
cord-259748-x7dq1sy4	255	62	,	,	,
cord-259748-x7dq1sy4	255	63	"	"	''
cord-259748-x7dq1sy4	255	64	which	which	WDT
cord-259748-x7dq1sy4	255	65	also	also	RB
cord-259748-x7dq1sy4	255	66	has	have	VBZ
cord-259748-x7dq1sy4	255	67	a	a	DT
cord-259748-x7dq1sy4	255	68	role	role	NN
cord-259748-x7dq1sy4	255	69	in	in	IN
cord-259748-x7dq1sy4	255	70	repair	repair	NN
cord-259748-x7dq1sy4	255	71	of	of	IN
cord-259748-x7dq1sy4	255	72	DNA	dna	NN
cord-259748-x7dq1sy4	255	73	damage	damage	NN
cord-259748-x7dq1sy4	255	74	and	and	CC
cord-259748-x7dq1sy4	255	75	transduction	transduction	NN
cord-259748-x7dq1sy4	255	76	of	of	IN
cord-259748-x7dq1sy4	255	77	genotoxic	genotoxic	JJ
cord-259748-x7dq1sy4	255	78	signals	signal	NNS
cord-259748-x7dq1sy4	255	79	(	(	-LRB-
cord-259748-x7dq1sy4	255	80	138	138	CD
cord-259748-x7dq1sy4	255	81	)	)	-RRB-
cord-259748-x7dq1sy4	255	82	.	.	.
cord-259748-x7dq1sy4	256	1	This	this	DT
cord-259748-x7dq1sy4	256	2	complex	complex	NN
cord-259748-x7dq1sy4	256	3	is	be	VBZ
cord-259748-x7dq1sy4	256	4	also	also	RB
cord-259748-x7dq1sy4	256	5	required	require	VBN
cord-259748-x7dq1sy4	256	6	to	to	TO
cord-259748-x7dq1sy4	256	7	accompany	accompany	VB
cord-259748-x7dq1sy4	256	8	cGAS	cgas	NN
cord-259748-x7dq1sy4	256	9	-	-	HYPH
cord-259748-x7dq1sy4	256	10	PQBP1	PQBP1	NNS
cord-259748-x7dq1sy4	256	11	in	in	IN
cord-259748-x7dq1sy4	256	12	sensing	sense	VBG
cord-259748-x7dq1sy4	256	13	DNA	dna	NN
cord-259748-x7dq1sy4	256	14	virus	virus	NN
cord-259748-x7dq1sy4	256	15	,	,	,
cord-259748-x7dq1sy4	256	16	such	such	JJ
cord-259748-x7dq1sy4	256	17	as	as	IN
cord-259748-x7dq1sy4	256	18	Kaposi	Kaposi	NNP
cord-259748-x7dq1sy4	256	19	's	's	POS
cord-259748-x7dq1sy4	256	20	sarcoma	sarcoma	NN
cord-259748-x7dq1sy4	256	21	-	-	HYPH
cord-259748-x7dq1sy4	256	22	associated	associate	VBN
cord-259748-x7dq1sy4	256	23	herpes	herpes	NNP
cord-259748-x7dq1sy4	256	24	virus	virus	NN
cord-259748-x7dq1sy4	256	25	(	(	-LRB-
cord-259748-x7dq1sy4	256	26	139	139	CD
cord-259748-x7dq1sy4	256	27	)	)	-RRB-
cord-259748-x7dq1sy4	256	28	.	.	.
cord-259748-x7dq1sy4	257	1	In	in	IN
cord-259748-x7dq1sy4	257	2	addition	addition	NN
cord-259748-x7dq1sy4	257	3	,	,	,
cord-259748-x7dq1sy4	257	4	during	during	IN
cord-259748-x7dq1sy4	257	5	virus	virus	NN
cord-259748-x7dq1sy4	257	6	infection	infection	NN
cord-259748-x7dq1sy4	257	7	,	,	,
cord-259748-x7dq1sy4	257	8	STING	sting	NN
cord-259748-x7dq1sy4	257	9	activation	activation	NN
cord-259748-x7dq1sy4	257	10	can	can	MD
cord-259748-x7dq1sy4	257	11	lead	lead	VB
cord-259748-x7dq1sy4	257	12	to	to	IN
cord-259748-x7dq1sy4	257	13	global	global	JJ
cord-259748-x7dq1sy4	257	14	suppression	suppression	NN
cord-259748-x7dq1sy4	257	15	of	of	IN
cord-259748-x7dq1sy4	257	16	translation	translation	NN
cord-259748-x7dq1sy4	257	17	in	in	IN
cord-259748-x7dq1sy4	257	18	cells	cell	NNS
cord-259748-x7dq1sy4	257	19	,	,	,
cord-259748-x7dq1sy4	257	20	which	which	WDT
cord-259748-x7dq1sy4	257	21	restricts	restrict	VBZ
cord-259748-x7dq1sy4	257	22	viral	viral	JJ
cord-259748-x7dq1sy4	257	23	replication	replication	NN
cord-259748-x7dq1sy4	257	24	(	(	-LRB-
cord-259748-x7dq1sy4	257	25	140	140	CD
cord-259748-x7dq1sy4	257	26	)	)	-RRB-
cord-259748-x7dq1sy4	257	27	.	.	.
cord-259748-x7dq1sy4	258	1	Compared	compare	VBN
cord-259748-x7dq1sy4	258	2	with	with	IN
cord-259748-x7dq1sy4	258	3	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	258	4	,	,	,
cord-259748-x7dq1sy4	258	5	HIV-2	HIV-2	NNP
cord-259748-x7dq1sy4	258	6	is	be	VBZ
cord-259748-x7dq1sy4	258	7	less	less	RBR
cord-259748-x7dq1sy4	258	8	infective	infective	JJ
cord-259748-x7dq1sy4	258	9	because	because	IN
cord-259748-x7dq1sy4	258	10	it	-PRON-	PRP
cord-259748-x7dq1sy4	258	11	can	can	MD
cord-259748-x7dq1sy4	258	12	infect	infect	VB
cord-259748-x7dq1sy4	258	13	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	258	14	cells	cell	NNS
cord-259748-x7dq1sy4	258	15	(	(	-LRB-
cord-259748-x7dq1sy4	258	16	DCs	DCs	NNP
cord-259748-x7dq1sy4	258	17	)	)	-RRB-
cord-259748-x7dq1sy4	258	18	and	and	CC
cord-259748-x7dq1sy4	258	19	elicit	elicit	VB
cord-259748-x7dq1sy4	258	20	an	an	DT
cord-259748-x7dq1sy4	258	21	anti	anti	JJ
cord-259748-x7dq1sy4	258	22	-	-	JJ
cord-259748-x7dq1sy4	258	23	virus	virus	JJ
cord-259748-x7dq1sy4	258	24	immune	immune	JJ
cord-259748-x7dq1sy4	258	25	response	response	NN
cord-259748-x7dq1sy4	258	26	.	.	.
cord-259748-x7dq1sy4	259	1	As	as	IN
cord-259748-x7dq1sy4	259	2	a	a	DT
cord-259748-x7dq1sy4	259	3	result	result	NN
cord-259748-x7dq1sy4	259	4	,	,	,
cord-259748-x7dq1sy4	259	5	HIV-2	HIV-2	NNP
cord-259748-x7dq1sy4	259	6	can	can	MD
cord-259748-x7dq1sy4	259	7	cross	cross	VB
cord-259748-x7dq1sy4	259	8	-	-	VB
cord-259748-x7dq1sy4	259	9	protect	protect	VB
cord-259748-x7dq1sy4	259	10	against	against	IN
cord-259748-x7dq1sy4	259	11	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	259	12	(	(	-LRB-
cord-259748-x7dq1sy4	259	13	141	141	CD
cord-259748-x7dq1sy4	259	14	)	)	-RRB-
cord-259748-x7dq1sy4	259	15	.	.	.
cord-259748-x7dq1sy4	260	1	This	this	DT
cord-259748-x7dq1sy4	260	2	phenomenon	phenomenon	NN
cord-259748-x7dq1sy4	260	3	has	have	VBZ
cord-259748-x7dq1sy4	260	4	been	be	VBN
cord-259748-x7dq1sy4	260	5	attributed	attribute	VBN
cord-259748-x7dq1sy4	260	6	to	to	IN
cord-259748-x7dq1sy4	260	7	the	the	DT
cord-259748-x7dq1sy4	260	8	fact	fact	NN
cord-259748-x7dq1sy4	260	9	that	that	IN
cord-259748-x7dq1sy4	260	10	HIV-2	HIV-2	NNP
cord-259748-x7dq1sy4	260	11	(	(	-LRB-
cord-259748-x7dq1sy4	260	12	instead	instead	RB
cord-259748-x7dq1sy4	260	13	of	of	IN
cord-259748-x7dq1sy4	260	14	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	260	15	)	)	-RRB-
cord-259748-x7dq1sy4	260	16	can	can	MD
cord-259748-x7dq1sy4	260	17	encode	encode	VB
cord-259748-x7dq1sy4	260	18	protein	protein	NN
cord-259748-x7dq1sy4	260	19	Vpx	Vpx	NNP
cord-259748-x7dq1sy4	260	20	,	,	,
cord-259748-x7dq1sy4	260	21	which	which	WDT
cord-259748-x7dq1sy4	260	22	overcomes	overcome	VBZ
cord-259748-x7dq1sy4	260	23	the	the	DT
cord-259748-x7dq1sy4	260	24	SAMHD1	SAMHD1	NNPS
cord-259748-x7dq1sy4	260	25	restriction	restriction	NN
cord-259748-x7dq1sy4	260	26	of	of	IN
cord-259748-x7dq1sy4	260	27	dNTP	dNTP	NNP
cord-259748-x7dq1sy4	260	28	in	in	IN
cord-259748-x7dq1sy4	260	29	DCs	DCs	NNP
cord-259748-x7dq1sy4	260	30	(	(	-LRB-
cord-259748-x7dq1sy4	260	31	46	46	CD
cord-259748-x7dq1sy4	260	32	,	,	,
cord-259748-x7dq1sy4	260	33	142	142	CD
cord-259748-x7dq1sy4	260	34	)	)	-RRB-
cord-259748-x7dq1sy4	260	35	.	.	.
cord-259748-x7dq1sy4	261	1	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	261	2	can	can	MD
cord-259748-x7dq1sy4	261	3	infect	infect	VB
cord-259748-x7dq1sy4	261	4	DCs	dc	NNS
cord-259748-x7dq1sy4	261	5	via	via	IN
cord-259748-x7dq1sy4	261	6	Vpx	Vpx	NNP
cord-259748-x7dq1sy4	261	7	presentation	presentation	NN
cord-259748-x7dq1sy4	261	8	,	,	,
cord-259748-x7dq1sy4	261	9	nevertheless	nevertheless	RB
cord-259748-x7dq1sy4	261	10	,	,	,
cord-259748-x7dq1sy4	261	11	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	261	12	still	still	RB
cord-259748-x7dq1sy4	261	13	can	can	MD
cord-259748-x7dq1sy4	261	14	not	not	RB
cord-259748-x7dq1sy4	261	15	be	be	VB
cord-259748-x7dq1sy4	261	16	fully	fully	RB
cord-259748-x7dq1sy4	261	17	sensed	sense	VBN
cord-259748-x7dq1sy4	261	18	and	and	CC
cord-259748-x7dq1sy4	261	19	induce	induce	VB
cord-259748-x7dq1sy4	261	20	an	an	DT
cord-259748-x7dq1sy4	261	21	efficient	efficient	JJ
cord-259748-x7dq1sy4	261	22	immune	immune	JJ
cord-259748-x7dq1sy4	261	23	response	response	NN
cord-259748-x7dq1sy4	261	24	owing	owe	VBG
cord-259748-x7dq1sy4	261	25	to	to	IN
cord-259748-x7dq1sy4	261	26	certain	certain	JJ
cord-259748-x7dq1sy4	261	27	escape	escape	NN
cord-259748-x7dq1sy4	261	28	mechanisms	mechanism	NNS
cord-259748-x7dq1sy4	261	29	.	.	.
cord-259748-x7dq1sy4	262	1	Whether	whether	IN
cord-259748-x7dq1sy4	262	2	it	-PRON-	PRP
cord-259748-x7dq1sy4	262	3	is	be	VBZ
cord-259748-x7dq1sy4	262	4	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	262	5	or	or	CC
cord-259748-x7dq1sy4	262	6	HIV-2	HIV-2	NNP
cord-259748-x7dq1sy4	262	7	,	,	,
cord-259748-x7dq1sy4	262	8	a	a	DT
cord-259748-x7dq1sy4	262	9	completely	completely	RB
cord-259748-x7dq1sy4	262	10	robust	robust	JJ
cord-259748-x7dq1sy4	262	11	IFN	IFN	NNP
cord-259748-x7dq1sy4	262	12	response	response	NN
cord-259748-x7dq1sy4	262	13	is	be	VBZ
cord-259748-x7dq1sy4	262	14	required	require	VBN
cord-259748-x7dq1sy4	262	15	at	at	IN
cord-259748-x7dq1sy4	262	16	pre	pre	JJ
cord-259748-x7dq1sy4	262	17	-	-	JJ
cord-259748-x7dq1sy4	262	18	and	and	CC
cord-259748-x7dq1sy4	262	19	post	post	JJ
cord-259748-x7dq1sy4	262	20	-	-	JJ
cord-259748-x7dq1sy4	262	21	integration	integration	JJ
cord-259748-x7dq1sy4	262	22	sensing	sensing	NN
cord-259748-x7dq1sy4	262	23	stages	stage	NNS
cord-259748-x7dq1sy4	262	24	(	(	-LRB-
cord-259748-x7dq1sy4	262	25	143	143	CD
cord-259748-x7dq1sy4	262	26	)	)	-RRB-
cord-259748-x7dq1sy4	262	27	.	.	.
cord-259748-x7dq1sy4	263	1	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	263	2	in	in	IN
cord-259748-x7dq1sy4	263	3	DCs	DCs	NNP
cord-259748-x7dq1sy4	263	4	can	can	MD
cord-259748-x7dq1sy4	263	5	detect	detect	VB
cord-259748-x7dq1sy4	263	6	reverse	reverse	RB
cord-259748-x7dq1sy4	263	7	-	-	HYPH
cord-259748-x7dq1sy4	263	8	transcribed	transcribe	VBN
cord-259748-x7dq1sy4	263	9	cDNA	cdna	NN
cord-259748-x7dq1sy4	263	10	of	of	IN
cord-259748-x7dq1sy4	263	11	HIV-2	HIV-2	NNP
cord-259748-x7dq1sy4	263	12	before	before	IN
cord-259748-x7dq1sy4	263	13	and	and	CC
cord-259748-x7dq1sy4	263	14	after	after	IN
cord-259748-x7dq1sy4	263	15	integration	integration	NN
cord-259748-x7dq1sy4	263	16	,	,	,
cord-259748-x7dq1sy4	263	17	whereas	whereas	IN
cord-259748-x7dq1sy4	263	18	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	263	19	sensing	sensing	NN
cord-259748-x7dq1sy4	263	20	is	be	VBZ
cord-259748-x7dq1sy4	263	21	after	after	IN
cord-259748-x7dq1sy4	263	22	genome	genome	NN
cord-259748-x7dq1sy4	263	23	integration	integration	NN
cord-259748-x7dq1sy4	263	24	owing	owe	VBG
cord-259748-x7dq1sy4	263	25	to	to	IN
cord-259748-x7dq1sy4	263	26	its	-PRON-	PRP$
cord-259748-x7dq1sy4	263	27	capsid	capsid	NN
cord-259748-x7dq1sy4	263	28	protection	protection	NN
cord-259748-x7dq1sy4	263	29	(	(	-LRB-
cord-259748-x7dq1sy4	263	30	144	144	CD
cord-259748-x7dq1sy4	263	31	,	,	,
cord-259748-x7dq1sy4	263	32	145	145	CD
cord-259748-x7dq1sy4	263	33	)	)	-RRB-
cord-259748-x7dq1sy4	263	34	.	.	.
cord-259748-x7dq1sy4	264	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	264	2	was	be	VBD
cord-259748-x7dq1sy4	264	3	suggested	suggest	VBN
cord-259748-x7dq1sy4	264	4	that	that	IN
cord-259748-x7dq1sy4	264	5	during	during	IN
cord-259748-x7dq1sy4	264	6	initial	initial	JJ
cord-259748-x7dq1sy4	264	7	infection	infection	NN
cord-259748-x7dq1sy4	264	8	by	by	IN
cord-259748-x7dq1sy4	264	9	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	264	10	,	,	,
cord-259748-x7dq1sy4	264	11	nucleotides	nucleotide	NNS
cord-259748-x7dq1sy4	264	12	are	be	VBP
cord-259748-x7dq1sy4	264	13	recruited	recruit	VBN
cord-259748-x7dq1sy4	264	14	into	into	IN
cord-259748-x7dq1sy4	264	15	the	the	DT
cord-259748-x7dq1sy4	264	16	intact	intact	JJ
cord-259748-x7dq1sy4	264	17	capsid	capsid	NN
cord-259748-x7dq1sy4	264	18	through	through	IN
cord-259748-x7dq1sy4	264	19	the	the	DT
cord-259748-x7dq1sy4	264	20	hexamer	hexamer	NN
cord-259748-x7dq1sy4	264	21	pores	pore	NNS
cord-259748-x7dq1sy4	264	22	on	on	IN
cord-259748-x7dq1sy4	264	23	the	the	DT
cord-259748-x7dq1sy4	264	24	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	264	25	capsid	capsid	NN
cord-259748-x7dq1sy4	264	26	.	.	.
cord-259748-x7dq1sy4	265	1	Therefore	therefore	RB
cord-259748-x7dq1sy4	265	2	,	,	,
cord-259748-x7dq1sy4	265	3	the	the	DT
cord-259748-x7dq1sy4	265	4	capsid	capsid	NN
cord-259748-x7dq1sy4	265	5	-	-	HYPH
cord-259748-x7dq1sy4	265	6	coated	coat	VBN
cord-259748-x7dq1sy4	265	7	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	265	8	virus	virus	NN
cord-259748-x7dq1sy4	265	9	prevents	prevent	VBZ
cord-259748-x7dq1sy4	265	10	the	the	DT
cord-259748-x7dq1sy4	265	11	encapsidated	encapsidate	VBN
cord-259748-x7dq1sy4	265	12	reverse	reverse	NN
cord-259748-x7dq1sy4	265	13	-	-	HYPH
cord-259748-x7dq1sy4	265	14	transcription	transcription	NN
cord-259748-x7dq1sy4	265	15	production	production	NN
cord-259748-x7dq1sy4	265	16	from	from	IN
cord-259748-x7dq1sy4	265	17	being	be	VBG
cord-259748-x7dq1sy4	265	18	sensed	sense	VBN
cord-259748-x7dq1sy4	265	19	by	by	IN
cord-259748-x7dq1sy4	265	20	the	the	DT
cord-259748-x7dq1sy4	265	21	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	265	22	nucleic	nucleic	JJ
cord-259748-x7dq1sy4	265	23	-	-	HYPH
cord-259748-x7dq1sy4	265	24	acid	acid	NN
cord-259748-x7dq1sy4	265	25	sensors	sensor	NNS
cord-259748-x7dq1sy4	265	26	(	(	-LRB-
cord-259748-x7dq1sy4	265	27	146	146	CD
cord-259748-x7dq1sy4	265	28	)	)	-RRB-
cord-259748-x7dq1sy4	265	29	.	.	.
cord-259748-x7dq1sy4	266	1	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	266	2	capsids	capsid	NNS
cord-259748-x7dq1sy4	266	3	can	can	MD
cord-259748-x7dq1sy4	266	4	be	be	VB
cord-259748-x7dq1sy4	266	5	ubiquitinated	ubiquitinate	VBN
cord-259748-x7dq1sy4	266	6	and	and	CC
cord-259748-x7dq1sy4	266	7	then	then	RB
cord-259748-x7dq1sy4	266	8	degraded	degrade	VBN
cord-259748-x7dq1sy4	266	9	by	by	IN
cord-259748-x7dq1sy4	266	10	the	the	DT
cord-259748-x7dq1sy4	266	11	host	host	NN
cord-259748-x7dq1sy4	266	12	E3	e3	NN
cord-259748-x7dq1sy4	266	13	ubiquitin	ubiquitin	NN
cord-259748-x7dq1sy4	266	14	ligase	ligase	NN
cord-259748-x7dq1sy4	266	15	function	function	NN
cord-259748-x7dq1sy4	266	16	of	of	IN
cord-259748-x7dq1sy4	266	17	TRIM5	TRIM5	NNP
cord-259748-x7dq1sy4	266	18	,	,	,
cord-259748-x7dq1sy4	266	19	which	which	WDT
cord-259748-x7dq1sy4	266	20	leads	lead	VBZ
cord-259748-x7dq1sy4	266	21	to	to	IN
cord-259748-x7dq1sy4	266	22	detection	detection	NN
cord-259748-x7dq1sy4	266	23	of	of	IN
cord-259748-x7dq1sy4	266	24	viral	viral	JJ
cord-259748-x7dq1sy4	266	25	DNA	dna	NN
cord-259748-x7dq1sy4	266	26	,	,	,
cord-259748-x7dq1sy4	266	27	meanwhile	meanwhile	RB
cord-259748-x7dq1sy4	266	28	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	266	29	could	could	MD
cord-259748-x7dq1sy4	266	30	use	use	VB
cord-259748-x7dq1sy4	266	31	some	some	DT
cord-259748-x7dq1sy4	266	32	host	host	NN
cord-259748-x7dq1sy4	266	33	protein	protein	NN
cord-259748-x7dq1sy4	266	34	like	like	IN
cord-259748-x7dq1sy4	266	35	cyclophilins	cyclophilin	NNS
cord-259748-x7dq1sy4	266	36	to	to	TO
cord-259748-x7dq1sy4	266	37	evade	evade	VB
cord-259748-x7dq1sy4	266	38	the	the	DT
cord-259748-x7dq1sy4	266	39	sensing	sensing	NN
cord-259748-x7dq1sy4	266	40	(	(	-LRB-
cord-259748-x7dq1sy4	266	41	147	147	CD
cord-259748-x7dq1sy4	266	42	,	,	,
cord-259748-x7dq1sy4	266	43	148	148	CD
cord-259748-x7dq1sy4	266	44	)	)	-RRB-
cord-259748-x7dq1sy4	266	45	(	(	-LRB-
cord-259748-x7dq1sy4	266	46	Figure	figure	NN
cord-259748-x7dq1sy4	266	47	2A	2a	CD
cord-259748-x7dq1sy4	266	48	)	)	-RRB-
cord-259748-x7dq1sy4	266	49	.	.	.
cord-259748-x7dq1sy4	267	1	Similarly	similarly	RB
cord-259748-x7dq1sy4	267	2	,	,	,
cord-259748-x7dq1sy4	267	3	other	other	JJ
cord-259748-x7dq1sy4	267	4	viruses	virus	NNS
cord-259748-x7dq1sy4	267	5	also	also	RB
cord-259748-x7dq1sy4	267	6	have	have	VBP
cord-259748-x7dq1sy4	267	7	evasion	evasion	NN
cord-259748-x7dq1sy4	267	8	mechanisms	mechanism	NNS
cord-259748-x7dq1sy4	267	9	to	to	TO
cord-259748-x7dq1sy4	267	10	escape	escape	VB
cord-259748-x7dq1sy4	267	11	cGAS	cgas	JJ
cord-259748-x7dq1sy4	267	12	-	-	HYPH
cord-259748-x7dq1sy4	267	13	STING	sting	NN
cord-259748-x7dq1sy4	267	14	pathway	pathway	NN
cord-259748-x7dq1sy4	267	15	surveillance	surveillance	NN
cord-259748-x7dq1sy4	267	16	(	(	-LRB-
cord-259748-x7dq1sy4	267	17	Table	Table	NNP
cord-259748-x7dq1sy4	267	18	3	3	CD
cord-259748-x7dq1sy4	267	19	)	)	-RRB-
cord-259748-x7dq1sy4	267	20	.	.	.
cord-259748-x7dq1sy4	268	1	Therefore	therefore	RB
cord-259748-x7dq1sy4	268	2	,	,	,
cord-259748-x7dq1sy4	268	3	identifying	identify	VBG
cord-259748-x7dq1sy4	268	4	and	and	CC
cord-259748-x7dq1sy4	268	5	preventing	prevent	VBG
cord-259748-x7dq1sy4	268	6	such	such	JJ
cord-259748-x7dq1sy4	268	7	viral	viral	JJ
cord-259748-x7dq1sy4	268	8	-	-	HYPH
cord-259748-x7dq1sy4	268	9	evasion	evasion	NN
cord-259748-x7dq1sy4	268	10	factors	factor	NNS
cord-259748-x7dq1sy4	268	11	could	could	MD
cord-259748-x7dq1sy4	268	12	be	be	VB
cord-259748-x7dq1sy4	268	13	a	a	DT
cord-259748-x7dq1sy4	268	14	viable	viable	JJ
cord-259748-x7dq1sy4	268	15	means	mean	NNS
cord-259748-x7dq1sy4	268	16	to	to	TO
cord-259748-x7dq1sy4	268	17	design	design	VB
cord-259748-x7dq1sy4	268	18	novel	novel	JJ
cord-259748-x7dq1sy4	268	19	anti	anti	JJ
cord-259748-x7dq1sy4	268	20	-	-	JJ
cord-259748-x7dq1sy4	268	21	viral	viral	JJ
cord-259748-x7dq1sy4	268	22	drugs	drug	NNS
cord-259748-x7dq1sy4	268	23	.	.	.
cord-259748-x7dq1sy4	269	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	269	2	-	-	HYPH
cord-259748-x7dq1sy4	269	3	STING	sting	NN
cord-259748-x7dq1sy4	269	4	pathway	pathway	NN
cord-259748-x7dq1sy4	269	5	is	be	VBZ
cord-259748-x7dq1sy4	269	6	responsible	responsible	JJ
cord-259748-x7dq1sy4	269	7	to	to	TO
cord-259748-x7dq1sy4	269	8	protect	protect	VB
cord-259748-x7dq1sy4	269	9	against	against	IN
cord-259748-x7dq1sy4	269	10	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	269	11	or	or	CC
cord-259748-x7dq1sy4	269	12	extracellular	extracellular	JJ
cord-259748-x7dq1sy4	269	13	bacterial	bacterial	JJ
cord-259748-x7dq1sy4	269	14	infection	infection	NN
cord-259748-x7dq1sy4	269	15	(	(	-LRB-
cord-259748-x7dq1sy4	269	16	especially	especially	RB
cord-259748-x7dq1sy4	269	17	HSV	HSV	NNP
cord-259748-x7dq1sy4	269	18	,	,	,
cord-259748-x7dq1sy4	269	19	herpes	herpes	NN
cord-259748-x7dq1sy4	269	20	simplex	simplex	NN
cord-259748-x7dq1sy4	269	21	virus	virus	NN
cord-259748-x7dq1sy4	269	22	;	;	:
cord-259748-x7dq1sy4	269	23	CMV	CMV	NNP
cord-259748-x7dq1sy4	269	24	,	,	,
cord-259748-x7dq1sy4	269	25	cytomegalovirus	cytomegalovirus	NNP
cord-259748-x7dq1sy4	269	26	;	;	:
cord-259748-x7dq1sy4	269	27	iRhom2	iRhom2	NNP
cord-259748-x7dq1sy4	269	28	,	,	,
cord-259748-x7dq1sy4	269	29	inactive	inactive	JJ
cord-259748-x7dq1sy4	269	30	rhomboid	rhomboid	JJ
cord-259748-x7dq1sy4	269	31	protein	protein	NN
cord-259748-x7dq1sy4	269	32	2	2	CD
cord-259748-x7dq1sy4	269	33	;	;	:
cord-259748-x7dq1sy4	269	34	TRAPβ	TRAPβ	NNP
cord-259748-x7dq1sy4	269	35	,	,	,
cord-259748-x7dq1sy4	269	36	translocon	translocon	NN
cord-259748-x7dq1sy4	269	37	-	-	HYPH
cord-259748-x7dq1sy4	269	38	associated	associate	VBN
cord-259748-x7dq1sy4	269	39	protein	protein	NN
cord-259748-x7dq1sy4	269	40	β	β	NN
cord-259748-x7dq1sy4	269	41	;	;	:
cord-259748-x7dq1sy4	269	42	KSHV	KSHV	NNP
cord-259748-x7dq1sy4	269	43	,	,	,
cord-259748-x7dq1sy4	269	44	kaposi	kaposi	NNP
cord-259748-x7dq1sy4	269	45	's	's	POS
cord-259748-x7dq1sy4	269	46	sarcoma	sarcoma	NN
cord-259748-x7dq1sy4	269	47	-	-	HYPH
cord-259748-x7dq1sy4	269	48	associated	associate	VBN
cord-259748-x7dq1sy4	269	49	herpes	herpes	NN
cord-259748-x7dq1sy4	269	50	virus	virus	NN
cord-259748-x7dq1sy4	269	51	;	;	:
cord-259748-x7dq1sy4	269	52	HDP	HDP	NNP
cord-259748-x7dq1sy4	269	53	-	-	HYPH
cord-259748-x7dq1sy4	269	54	RNP	RNP	NNP
cord-259748-x7dq1sy4	269	55	,	,	,
cord-259748-x7dq1sy4	269	56	HEXIM1-DNA	HEXIM1-DNA	NNP
cord-259748-x7dq1sy4	269	57	-	-	HYPH
cord-259748-x7dq1sy4	269	58	PK	pk	NN
cord-259748-x7dq1sy4	269	59	-	-	HYPH
cord-259748-x7dq1sy4	269	60	paraspecklecomponents	paraspecklecomponent	NNS
cord-259748-x7dq1sy4	269	61	-	-	HYPH
cord-259748-x7dq1sy4	269	62	ribonuclear	ribonuclear	NN
cord-259748-x7dq1sy4	269	63	protein	protein	NN
cord-259748-x7dq1sy4	269	64	complex	complex	NN
cord-259748-x7dq1sy4	269	65	;	;	:
cord-259748-x7dq1sy4	269	66	LANA	LANA	NNP
cord-259748-x7dq1sy4	269	67	,	,	,
cord-259748-x7dq1sy4	269	68	latency	latency	NN
cord-259748-x7dq1sy4	269	69	-	-	HYPH
cord-259748-x7dq1sy4	269	70	associated	associate	VBN
cord-259748-x7dq1sy4	269	71	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	269	72	antigen	antigen	NN
cord-259748-x7dq1sy4	269	73	;	;	:
cord-259748-x7dq1sy4	269	74	vIRF1	vIRF1	NNP
cord-259748-x7dq1sy4	269	75	,	,	,
cord-259748-x7dq1sy4	269	76	viral	viral	JJ
cord-259748-x7dq1sy4	269	77	interferon	interferon	NN
cord-259748-x7dq1sy4	269	78	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	269	79	factor	factor	NN
cord-259748-x7dq1sy4	269	80	1	1	CD
cord-259748-x7dq1sy4	269	81	;	;	:
cord-259748-x7dq1sy4	269	82	PLPro	PLPro	NNP
cord-259748-x7dq1sy4	269	83	,	,	,
cord-259748-x7dq1sy4	269	84	papain	papain	NN
cord-259748-x7dq1sy4	269	85	-	-	HYPH
cord-259748-x7dq1sy4	269	86	like	like	JJ
cord-259748-x7dq1sy4	269	87	protease	protease	NN
cord-259748-x7dq1sy4	269	88	;	;	:
cord-259748-x7dq1sy4	269	89	LC3	LC3	NNP
cord-259748-x7dq1sy4	269	90	,	,	,
cord-259748-x7dq1sy4	269	91	light	light	JJ
cord-259748-x7dq1sy4	269	92	chain3	chain3	NN
cord-259748-x7dq1sy4	269	93	;	;	:
cord-259748-x7dq1sy4	269	94	mTOR	mTOR	NNP
cord-259748-x7dq1sy4	269	95	,	,	,
cord-259748-x7dq1sy4	269	96	mechanistic	mechanistic	JJ
cord-259748-x7dq1sy4	269	97	target	target	NN
cord-259748-x7dq1sy4	269	98	of	of	IN
cord-259748-x7dq1sy4	269	99	rapamycin	rapamycin	NN
cord-259748-x7dq1sy4	269	100	;	;	:
cord-259748-x7dq1sy4	269	101	TRAF3	TRAF3	NNP
cord-259748-x7dq1sy4	269	102	,	,	,
cord-259748-x7dq1sy4	269	103	TNF	TNF	NNP
cord-259748-x7dq1sy4	269	104	receptor	receptor	NN
cord-259748-x7dq1sy4	269	105	associated	associate	VBD
cord-259748-x7dq1sy4	269	106	factor	factor	NN
cord-259748-x7dq1sy4	269	107	3	3	CD
cord-259748-x7dq1sy4	269	108	;	;	:
cord-259748-x7dq1sy4	269	109	HCV	HCV	NNP
cord-259748-x7dq1sy4	269	110	,	,	,
cord-259748-x7dq1sy4	269	111	hepatitis	hepatitis	NN
cord-259748-x7dq1sy4	269	112	c	c	NN
cord-259748-x7dq1sy4	269	113	virus	virus	NN
cord-259748-x7dq1sy4	269	114	;	;	:
cord-259748-x7dq1sy4	269	115	HPV	hpv	NN
cord-259748-x7dq1sy4	269	116	,	,	,
cord-259748-x7dq1sy4	269	117	human	human	JJ
cord-259748-x7dq1sy4	269	118	papilloma	papilloma	NN
cord-259748-x7dq1sy4	269	119	virus	virus	NN
cord-259748-x7dq1sy4	269	120	;	;	:
cord-259748-x7dq1sy4	269	121	HBV	HBV	NNP
cord-259748-x7dq1sy4	269	122	,	,	,
cord-259748-x7dq1sy4	269	123	hepatitis	hepatitis	NN
cord-259748-x7dq1sy4	269	124	B	B	NNP
cord-259748-x7dq1sy4	269	125	virus	virus	NN
cord-259748-x7dq1sy4	269	126	;	;	:
cord-259748-x7dq1sy4	269	127	HIV	HIV	NNP
cord-259748-x7dq1sy4	269	128	,	,	,
cord-259748-x7dq1sy4	269	129	human	human	JJ
cord-259748-x7dq1sy4	269	130	immunodeficiency	immunodeficiency	NN
cord-259748-x7dq1sy4	269	131	virus	virus	NN
cord-259748-x7dq1sy4	269	132	;	;	:
cord-259748-x7dq1sy4	269	133	NF	nf	NN
cord-259748-x7dq1sy4	269	134	-	-	HYPH
cord-259748-x7dq1sy4	269	135	κB	κB	NNP
cord-259748-x7dq1sy4	269	136	,	,	,
cord-259748-x7dq1sy4	269	137	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	269	138	factor	factor	NN
cord-259748-x7dq1sy4	269	139	-	-	HYPH
cord-259748-x7dq1sy4	269	140	κ	κ	NN
cord-259748-x7dq1sy4	269	141	B.	B.	NNP
cord-259748-x7dq1sy4	269	142	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	269	143	infections	infection	NNS
cord-259748-x7dq1sy4	269	144	)	)	-RRB-
cord-259748-x7dq1sy4	269	145	.	.	.
cord-259748-x7dq1sy4	270	1	CDNs	CDNs	NNP
cord-259748-x7dq1sy4	270	2	(	(	-LRB-
cord-259748-x7dq1sy4	270	3	e.g.	e.g.	RB
cord-259748-x7dq1sy4	270	4	,	,	,
cord-259748-x7dq1sy4	270	5	c	c	NNP
cord-259748-x7dq1sy4	270	6	-	-	HYPH
cord-259748-x7dq1sy4	270	7	dGMP	dGMP	NNP
cord-259748-x7dq1sy4	270	8	,	,	,
cord-259748-x7dq1sy4	270	9	c	c	NN
cord-259748-x7dq1sy4	270	10	-	-	HYPH
cord-259748-x7dq1sy4	270	11	dAMP	dAMP	NNP
cord-259748-x7dq1sy4	270	12	,	,	,
cord-259748-x7dq1sy4	270	13	and	and	CC
cord-259748-x7dq1sy4	270	14	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	270	15	)	)	-RRB-
cord-259748-x7dq1sy4	270	16	produced	produce	VBN
cord-259748-x7dq1sy4	270	17	by	by	IN
cord-259748-x7dq1sy4	270	18	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	270	19	are	be	VBP
cord-259748-x7dq1sy4	270	20	essential	essential	JJ
cord-259748-x7dq1sy4	270	21	for	for	IN
cord-259748-x7dq1sy4	270	22	the	the	DT
cord-259748-x7dq1sy4	270	23	regulation	regulation	NN
cord-259748-x7dq1sy4	270	24	of	of	IN
cord-259748-x7dq1sy4	270	25	bacterial	bacterial	JJ
cord-259748-x7dq1sy4	270	26	function	function	NN
cord-259748-x7dq1sy4	270	27	,	,	,
cord-259748-x7dq1sy4	270	28	such	such	JJ
cord-259748-x7dq1sy4	270	29	as	as	IN
cord-259748-x7dq1sy4	270	30	biofilm	biofilm	NN
cord-259748-x7dq1sy4	270	31	formation	formation	NN
cord-259748-x7dq1sy4	270	32	,	,	,
cord-259748-x7dq1sy4	270	33	colonization	colonization	NN
cord-259748-x7dq1sy4	270	34	,	,	,
cord-259748-x7dq1sy4	270	35	and	and	CC
cord-259748-x7dq1sy4	270	36	reproduction	reproduction	NN
cord-259748-x7dq1sy4	270	37	(	(	-LRB-
cord-259748-x7dq1sy4	270	38	149	149	CD
cord-259748-x7dq1sy4	270	39	,	,	,
cord-259748-x7dq1sy4	270	40	150	150	CD
cord-259748-x7dq1sy4	270	41	)	)	-RRB-
cord-259748-x7dq1sy4	270	42	.	.	.
cord-259748-x7dq1sy4	271	1	As	as	IN
cord-259748-x7dq1sy4	271	2	ligands	ligand	NNS
cord-259748-x7dq1sy4	271	3	for	for	IN
cord-259748-x7dq1sy4	271	4	STING	sting	NN
cord-259748-x7dq1sy4	271	5	,	,	,
cord-259748-x7dq1sy4	271	6	CDNs	cdn	NNS
cord-259748-x7dq1sy4	271	7	can	can	MD
cord-259748-x7dq1sy4	271	8	bind	bind	VB
cord-259748-x7dq1sy4	271	9	directly	directly	RB
cord-259748-x7dq1sy4	271	10	to	to	TO
cord-259748-x7dq1sy4	271	11	and	and	CC
cord-259748-x7dq1sy4	271	12	activate	activate	VB
cord-259748-x7dq1sy4	271	13	STING	sting	NN
cord-259748-x7dq1sy4	271	14	independently	independently	RB
cord-259748-x7dq1sy4	271	15	of	of	IN
cord-259748-x7dq1sy4	271	16	cGAS	cgas	NN
cord-259748-x7dq1sy4	271	17	,	,	,
cord-259748-x7dq1sy4	271	18	which	which	WDT
cord-259748-x7dq1sy4	271	19	contributes	contribute	VBZ
cord-259748-x7dq1sy4	271	20	to	to	IN
cord-259748-x7dq1sy4	271	21	several	several	JJ
cord-259748-x7dq1sy4	271	22	immune	immune	JJ
cord-259748-x7dq1sy4	271	23	responses	response	NNS
cord-259748-x7dq1sy4	271	24	from	from	IN
cord-259748-x7dq1sy4	271	25	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	271	26	(	(	-LRB-
cord-259748-x7dq1sy4	271	27	151	151	CD
cord-259748-x7dq1sy4	271	28	)	)	-RRB-
cord-259748-x7dq1sy4	271	29	.	.	.
cord-259748-x7dq1sy4	272	1	Usually	usually	RB
cord-259748-x7dq1sy4	272	2	,	,	,
cord-259748-x7dq1sy4	272	3	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	272	4	can	can	MD
cord-259748-x7dq1sy4	272	5	enter	enter	VB
cord-259748-x7dq1sy4	272	6	or	or	CC
cord-259748-x7dq1sy4	272	7	be	be	VB
cord-259748-x7dq1sy4	272	8	engulfed	engulf	VBN
cord-259748-x7dq1sy4	272	9	by	by	IN
cord-259748-x7dq1sy4	272	10	the	the	DT
cord-259748-x7dq1sy4	272	11	cell	cell	NN
cord-259748-x7dq1sy4	272	12	through	through	IN
cord-259748-x7dq1sy4	272	13	the	the	DT
cord-259748-x7dq1sy4	272	14	endophagosome	endophagosome	NN
cord-259748-x7dq1sy4	272	15	and	and	CC
cord-259748-x7dq1sy4	272	16	be	be	VB
cord-259748-x7dq1sy4	272	17	sequestered	sequester	VBN
cord-259748-x7dq1sy4	272	18	from	from	IN
cord-259748-x7dq1sy4	272	19	the	the	DT
cord-259748-x7dq1sy4	272	20	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	272	21	sense	sense	NN
cord-259748-x7dq1sy4	272	22	receptor	receptor	NN
cord-259748-x7dq1sy4	272	23	.	.	.
cord-259748-x7dq1sy4	273	1	Some	some	DT
cord-259748-x7dq1sy4	273	2	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	273	3	,	,	,
cord-259748-x7dq1sy4	273	4	such	such	JJ
cord-259748-x7dq1sy4	273	5	as	as	IN
cord-259748-x7dq1sy4	273	6	Mycobacterium	Mycobacterium	NNP
cord-259748-x7dq1sy4	273	7	tuberculosis	tuberculosis	NN
cord-259748-x7dq1sy4	273	8	(	(	-LRB-
cord-259748-x7dq1sy4	273	9	Mtb	Mtb	NNP
cord-259748-x7dq1sy4	273	10	)	)	-RRB-
cord-259748-x7dq1sy4	273	11	,	,	,
cord-259748-x7dq1sy4	273	12	can	can	MD
cord-259748-x7dq1sy4	273	13	survive	survive	VB
cord-259748-x7dq1sy4	273	14	in	in	IN
cord-259748-x7dq1sy4	273	15	vacuoles	vacuole	NNS
cord-259748-x7dq1sy4	273	16	,	,	,
cord-259748-x7dq1sy4	273	17	resulting	result	VBG
cord-259748-x7dq1sy4	273	18	in	in	IN
cord-259748-x7dq1sy4	273	19	an	an	DT
cord-259748-x7dq1sy4	273	20	insufficient	insufficient	JJ
cord-259748-x7dq1sy4	273	21	cellular	cellular	JJ
cord-259748-x7dq1sy4	273	22	immune	immune	JJ
cord-259748-x7dq1sy4	273	23	response	response	NN
cord-259748-x7dq1sy4	273	24	to	to	TO
cord-259748-x7dq1sy4	273	25	defend	defend	VB
cord-259748-x7dq1sy4	273	26	against	against	IN
cord-259748-x7dq1sy4	273	27	it	-PRON-	PRP
cord-259748-x7dq1sy4	273	28	(	(	-LRB-
cord-259748-x7dq1sy4	273	29	152	152	CD
cord-259748-x7dq1sy4	273	30	)	)	-RRB-
cord-259748-x7dq1sy4	273	31	.	.	.
cord-259748-x7dq1sy4	274	1	In	in	IN
cord-259748-x7dq1sy4	274	2	contrast	contrast	NN
cord-259748-x7dq1sy4	274	3	,	,	,
cord-259748-x7dq1sy4	274	4	the	the	DT
cord-259748-x7dq1sy4	274	5	ESX-1	ESX-1	NNP
cord-259748-x7dq1sy4	274	6	secretion	secretion	NN
cord-259748-x7dq1sy4	274	7	system	system	NN
cord-259748-x7dq1sy4	274	8	of	of	IN
cord-259748-x7dq1sy4	274	9	the	the	DT
cord-259748-x7dq1sy4	274	10	mycobacterium	mycobacterium	NN
cord-259748-x7dq1sy4	274	11	can	can	MD
cord-259748-x7dq1sy4	274	12	translocate	translocate	VB
cord-259748-x7dq1sy4	274	13	the	the	DT
cord-259748-x7dq1sy4	274	14	phagosomal	phagosomal	NNP
cord-259748-x7dq1sy4	274	15	vacuolar	vacuolar	NNP
cord-259748-x7dq1sy4	274	16	matrix	matrix	NN
cord-259748-x7dq1sy4	274	17	including	include	VBG
cord-259748-x7dq1sy4	274	18	bacterial	bacterial	JJ
cord-259748-x7dq1sy4	274	19	genome	genome	NN
cord-259748-x7dq1sy4	274	20	molecules	molecule	NNS
cord-259748-x7dq1sy4	274	21	into	into	IN
cord-259748-x7dq1sy4	274	22	the	the	DT
cord-259748-x7dq1sy4	274	23	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	274	24	and	and	CC
cord-259748-x7dq1sy4	274	25	trigger	trigger	VB
cord-259748-x7dq1sy4	274	26	the	the	DT
cord-259748-x7dq1sy4	274	27	cGAS	cgas	NN
cord-259748-x7dq1sy4	274	28	-	-	HYPH
cord-259748-x7dq1sy4	274	29	sensing	sense	VBG
cord-259748-x7dq1sy4	274	30	pathway	pathway	NN
cord-259748-x7dq1sy4	274	31	(	(	-LRB-
cord-259748-x7dq1sy4	274	32	153	153	CD
cord-259748-x7dq1sy4	274	33	)	)	-RRB-
cord-259748-x7dq1sy4	274	34	.	.	.
cord-259748-x7dq1sy4	275	1	For	for	IN
cord-259748-x7dq1sy4	275	2	other	other	JJ
cord-259748-x7dq1sy4	275	3	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	275	4	,	,	,
cord-259748-x7dq1sy4	275	5	such	such	JJ
cord-259748-x7dq1sy4	275	6	as	as	IN
cord-259748-x7dq1sy4	275	7	Legionella	Legionella	NNP
cord-259748-x7dq1sy4	275	8	pneumophila	pneumophila	NN
cord-259748-x7dq1sy4	275	9	or	or	CC
cord-259748-x7dq1sy4	275	10	and	and	CC
cord-259748-x7dq1sy4	275	11	Brucella	Brucella	NNP
cord-259748-x7dq1sy4	275	12	abortus	abortus	NN
cord-259748-x7dq1sy4	275	13	,	,	,
cord-259748-x7dq1sy4	275	14	the	the	DT
cord-259748-x7dq1sy4	275	15	host	host	NN
cord-259748-x7dq1sy4	275	16	guanylate	guanylate	NN
cord-259748-x7dq1sy4	275	17	binding	bind	VBG
cord-259748-x7dq1sy4	275	18	proteins	protein	NNS
cord-259748-x7dq1sy4	275	19	(	(	-LRB-
cord-259748-x7dq1sy4	275	20	GBPs	gbp	NNS
cord-259748-x7dq1sy4	275	21	)	)	-RRB-
cord-259748-x7dq1sy4	275	22	facilitate	facilitate	VBP
cord-259748-x7dq1sy4	275	23	rupture	rupture	NN
cord-259748-x7dq1sy4	275	24	of	of	IN
cord-259748-x7dq1sy4	275	25	phagosome	phagosome	NN
cord-259748-x7dq1sy4	275	26	vacuoles	vacuole	NNS
cord-259748-x7dq1sy4	275	27	and	and	CC
cord-259748-x7dq1sy4	275	28	are	be	VBP
cord-259748-x7dq1sy4	275	29	indispensable	indispensable	JJ
cord-259748-x7dq1sy4	275	30	for	for	IN
cord-259748-x7dq1sy4	275	31	controlling	control	VBG
cord-259748-x7dq1sy4	275	32	their	-PRON-	PRP$
cord-259748-x7dq1sy4	275	33	infection	infection	NN
cord-259748-x7dq1sy4	275	34	(	(	-LRB-
cord-259748-x7dq1sy4	275	35	154	154	CD
cord-259748-x7dq1sy4	275	36	,	,	,
cord-259748-x7dq1sy4	275	37	155	155	CD
cord-259748-x7dq1sy4	275	38	)	)	-RRB-
cord-259748-x7dq1sy4	275	39	.	.	.
cord-259748-x7dq1sy4	276	1	Autophagy	Autophagy	NNP
cord-259748-x7dq1sy4	276	2	signaling	signal	VBG
cord-259748-x7dq1sy4	276	3	mediated	mediate	VBN
cord-259748-x7dq1sy4	276	4	by	by	IN
cord-259748-x7dq1sy4	276	5	cGAS	cgas	NN
cord-259748-x7dq1sy4	276	6	/	/	SYM
cord-259748-x7dq1sy4	276	7	STING	sting	NN
cord-259748-x7dq1sy4	276	8	is	be	VBZ
cord-259748-x7dq1sy4	276	9	also	also	RB
cord-259748-x7dq1sy4	276	10	involved	involve	VBN
cord-259748-x7dq1sy4	276	11	in	in	IN
cord-259748-x7dq1sy4	276	12	microorganism	microorganism	NN
cord-259748-x7dq1sy4	276	13	clearance	clearance	NN
cord-259748-x7dq1sy4	276	14	mentioned	mention	VBN
cord-259748-x7dq1sy4	276	15	above	above	RB
cord-259748-x7dq1sy4	276	16	(	(	-LRB-
cord-259748-x7dq1sy4	276	17	90	90	CD
cord-259748-x7dq1sy4	276	18	,	,	,
cord-259748-x7dq1sy4	276	19	91	91	CD
cord-259748-x7dq1sy4	276	20	)	)	-RRB-
cord-259748-x7dq1sy4	276	21	.	.	.
cord-259748-x7dq1sy4	277	1	Bacteria	Bacteria	NNS
cord-259748-x7dq1sy4	277	2	have	have	VBP
cord-259748-x7dq1sy4	277	3	evolved	evolve	VBN
cord-259748-x7dq1sy4	277	4	strategies	strategy	NNS
cord-259748-x7dq1sy4	277	5	to	to	TO
cord-259748-x7dq1sy4	277	6	confront	confront	VB
cord-259748-x7dq1sy4	277	7	this	this	DT
cord-259748-x7dq1sy4	277	8	pathway	pathway	NN
cord-259748-x7dq1sy4	277	9	too	too	RB
cord-259748-x7dq1sy4	277	10	.	.	.
cord-259748-x7dq1sy4	278	1	Bacterial	bacterial	JJ
cord-259748-x7dq1sy4	278	2	phosphodiesterase	phosphodiesterase	NN
cord-259748-x7dq1sy4	278	3	CdnP	CdnP	NNP
cord-259748-x7dq1sy4	278	4	produced	produce	VBN
cord-259748-x7dq1sy4	278	5	by	by	IN
cord-259748-x7dq1sy4	278	6	Mtb	Mtb	NNP
cord-259748-x7dq1sy4	278	7	or	or	CC
cord-259748-x7dq1sy4	278	8	group	group	NN
cord-259748-x7dq1sy4	278	9	-	-	HYPH
cord-259748-x7dq1sy4	278	10	B	b	NN
cord-259748-x7dq1sy4	278	11	streptococci	streptococcus	NNS
cord-259748-x7dq1sy4	278	12	can	can	MD
cord-259748-x7dq1sy4	278	13	degrade	degrade	VB
cord-259748-x7dq1sy4	278	14	CDNs	CDNs	NNP
cord-259748-x7dq1sy4	278	15	(	(	-LRB-
cord-259748-x7dq1sy4	278	16	156	156	CD
cord-259748-x7dq1sy4	278	17	,	,	,
cord-259748-x7dq1sy4	278	18	157	157	CD
cord-259748-x7dq1sy4	278	19	)	)	-RRB-
cord-259748-x7dq1sy4	278	20	.	.	.
cord-259748-x7dq1sy4	279	1	CpsA	CpsA	NNP
cord-259748-x7dq1sy4	279	2	(	(	-LRB-
cord-259748-x7dq1sy4	279	3	a	a	DT
cord-259748-x7dq1sy4	279	4	type	type	NN
cord-259748-x7dq1sy4	279	5	of	of	IN
cord-259748-x7dq1sy4	279	6	Mtb	Mtb	NNP
cord-259748-x7dq1sy4	279	7	LytR	LytR	NNP
cord-259748-x7dq1sy4	279	8	-	-	HYPH
cord-259748-x7dq1sy4	279	9	CpsA	CpsA	NNP
cord-259748-x7dq1sy4	279	10	-	-	HYPH
cord-259748-x7dq1sy4	279	11	Psr	Psr	NNP
cord-259748-x7dq1sy4	279	12	domain	domain	NN
cord-259748-x7dq1sy4	279	13	-	-	HYPH
cord-259748-x7dq1sy4	279	14	containing	contain	VBG
cord-259748-x7dq1sy4	279	15	protein	protein	NN
cord-259748-x7dq1sy4	279	16	)	)	-RRB-
cord-259748-x7dq1sy4	279	17	can	can	MD
cord-259748-x7dq1sy4	279	18	prevent	prevent	VB
cord-259748-x7dq1sy4	279	19	autophagy	autophagy	NN
cord-259748-x7dq1sy4	279	20	responses	response	NNS
cord-259748-x7dq1sy4	279	21	for	for	IN
cord-259748-x7dq1sy4	279	22	eliminating	eliminate	VBG
cord-259748-x7dq1sy4	279	23	pathogens	pathogen	NNS
cord-259748-x7dq1sy4	279	24	(	(	-LRB-
cord-259748-x7dq1sy4	279	25	90	90	CD
cord-259748-x7dq1sy4	279	26	)	)	-RRB-
cord-259748-x7dq1sy4	279	27	.	.	.
cord-259748-x7dq1sy4	280	1	Chlamydia	Chlamydia	NNP
cord-259748-x7dq1sy4	280	2	trachomatis	trachomatis	NN
cord-259748-x7dq1sy4	280	3	inclusion	inclusion	NN
cord-259748-x7dq1sy4	280	4	membrane	membrane	NN
cord-259748-x7dq1sy4	280	5	proteins	protein	NNS
cord-259748-x7dq1sy4	280	6	can	can	MD
cord-259748-x7dq1sy4	280	7	maintain	maintain	VB
cord-259748-x7dq1sy4	280	8	the	the	DT
cord-259748-x7dq1sy4	280	9	stability	stability	NN
cord-259748-x7dq1sy4	280	10	of	of	IN
cord-259748-x7dq1sy4	280	11	the	the	DT
cord-259748-x7dq1sy4	280	12	inclusion	inclusion	NN
cord-259748-x7dq1sy4	280	13	membrane	membrane	NN
cord-259748-x7dq1sy4	280	14	and	and	CC
cord-259748-x7dq1sy4	280	15	avoid	avoid	VB
cord-259748-x7dq1sy4	280	16	inclusion	inclusion	NN
cord-259748-x7dq1sy4	280	17	lysis	lysis	NN
cord-259748-x7dq1sy4	280	18	(	(	-LRB-
cord-259748-x7dq1sy4	280	19	leading	lead	VBG
cord-259748-x7dq1sy4	280	20	to	to	IN
cord-259748-x7dq1sy4	280	21	pathogen	pathogen	NN
cord-259748-x7dq1sy4	280	22	antigens	antigen	NNS
cord-259748-x7dq1sy4	280	23	leaking	leak	VBG
cord-259748-x7dq1sy4	280	24	out	out	RP
cord-259748-x7dq1sy4	280	25	and	and	CC
cord-259748-x7dq1sy4	280	26	being	be	VBG
cord-259748-x7dq1sy4	280	27	detected	detect	VBN
cord-259748-x7dq1sy4	280	28	by	by	IN
cord-259748-x7dq1sy4	280	29	the	the	DT
cord-259748-x7dq1sy4	280	30	host	host	NN
cord-259748-x7dq1sy4	280	31	cell	cell	NN
cord-259748-x7dq1sy4	280	32	)	)	-RRB-
cord-259748-x7dq1sy4	280	33	(	(	-LRB-
cord-259748-x7dq1sy4	280	34	158	158	CD
cord-259748-x7dq1sy4	280	35	,	,	,
cord-259748-x7dq1sy4	280	36	159	159	CD
cord-259748-x7dq1sy4	280	37	)	)	-RRB-
cord-259748-x7dq1sy4	280	38	.	.	.
cord-259748-x7dq1sy4	281	1	Yersinia	Yersinia	NNP
cord-259748-x7dq1sy4	281	2	outer	outer	JJ
cord-259748-x7dq1sy4	281	3	protein	protein	NN
cord-259748-x7dq1sy4	281	4	J	J	NNP
cord-259748-x7dq1sy4	281	5	(	(	-LRB-
cord-259748-x7dq1sy4	281	6	YopJ	YopJ	NNP
cord-259748-x7dq1sy4	281	7	)	)	-RRB-
cord-259748-x7dq1sy4	281	8	deubiquitinates	deubiquitinate	VBZ
cord-259748-x7dq1sy4	281	9	STING	STING	NNP
cord-259748-x7dq1sy4	281	10	and	and	CC
cord-259748-x7dq1sy4	281	11	impedes	impede	VBZ
cord-259748-x7dq1sy4	281	12	the	the	DT
cord-259748-x7dq1sy4	281	13	formation	formation	NN
cord-259748-x7dq1sy4	281	14	of	of	IN
cord-259748-x7dq1sy4	281	15	the	the	DT
cord-259748-x7dq1sy4	281	16	STING	sting	NN
cord-259748-x7dq1sy4	281	17	signalosome	signalosome	NN
cord-259748-x7dq1sy4	281	18	(	(	-LRB-
cord-259748-x7dq1sy4	281	19	160	160	CD
cord-259748-x7dq1sy4	281	20	)	)	-RRB-
cord-259748-x7dq1sy4	281	21	.	.	.
cord-259748-x7dq1sy4	282	1	The	the	DT
cord-259748-x7dq1sy4	282	2	cGAS	cgas	JJ
cord-259748-x7dq1sy4	282	3	-	-	HYPH
cord-259748-x7dq1sy4	282	4	STING	sting	NN
cord-259748-x7dq1sy4	282	5	pathway	pathway	NN
cord-259748-x7dq1sy4	282	6	activation	activation	NN
cord-259748-x7dq1sy4	282	7	even	even	RB
cord-259748-x7dq1sy4	282	8	impedes	impede	VBZ
cord-259748-x7dq1sy4	282	9	the	the	DT
cord-259748-x7dq1sy4	282	10	elimination	elimination	NN
cord-259748-x7dq1sy4	282	11	of	of	IN
cord-259748-x7dq1sy4	282	12	Listeria	Listeria	NNP
cord-259748-x7dq1sy4	282	13	monocytogenes	monocytogene	NNS
cord-259748-x7dq1sy4	282	14	because	because	IN
cord-259748-x7dq1sy4	282	15	bacterial	bacterial	JJ
cord-259748-x7dq1sy4	282	16	DNA	dna	NN
cord-259748-x7dq1sy4	282	17	can	can	MD
cord-259748-x7dq1sy4	282	18	be	be	VB
cord-259748-x7dq1sy4	282	19	packaged	package	VBN
cord-259748-x7dq1sy4	282	20	into	into	IN
cord-259748-x7dq1sy4	282	21	EVs	ev	NNS
cord-259748-x7dq1sy4	282	22	and	and	CC
cord-259748-x7dq1sy4	282	23	transferred	transfer	VBN
cord-259748-x7dq1sy4	282	24	into	into	IN
cord-259748-x7dq1sy4	282	25	T	T	NNP
cord-259748-x7dq1sy4	282	26	cells	cell	NNS
cord-259748-x7dq1sy4	282	27	,	,	,
cord-259748-x7dq1sy4	282	28	where	where	WRB
cord-259748-x7dq1sy4	282	29	it	-PRON-	PRP
cord-259748-x7dq1sy4	282	30	induces	induce	VBZ
cord-259748-x7dq1sy4	282	31	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	282	32	of	of	IN
cord-259748-x7dq1sy4	282	33	T	t	NN
cord-259748-x7dq1sy4	282	34	cells	cell	NNS
cord-259748-x7dq1sy4	282	35	(	(	-LRB-
cord-259748-x7dq1sy4	282	36	161	161	CD
cord-259748-x7dq1sy4	282	37	,	,	,
cord-259748-x7dq1sy4	282	38	162	162	CD
cord-259748-x7dq1sy4	282	39	)	)	-RRB-
cord-259748-x7dq1sy4	282	40	.	.	.
cord-259748-x7dq1sy4	283	1	Several	several	JJ
cord-259748-x7dq1sy4	283	2	protozoans	protozoan	NNS
cord-259748-x7dq1sy4	283	3	,	,	,
cord-259748-x7dq1sy4	283	4	such	such	JJ
cord-259748-x7dq1sy4	283	5	as	as	IN
cord-259748-x7dq1sy4	283	6	Toxoplasma	Toxoplasma	NNP
cord-259748-x7dq1sy4	283	7	gondii	gondii	NN
cord-259748-x7dq1sy4	283	8	and	and	CC
cord-259748-x7dq1sy4	283	9	malaria	malaria	NN
cord-259748-x7dq1sy4	283	10	parasites	parasite	NNS
cord-259748-x7dq1sy4	283	11	,	,	,
cord-259748-x7dq1sy4	283	12	have	have	VBP
cord-259748-x7dq1sy4	283	13	an	an	DT
cord-259748-x7dq1sy4	283	14	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	283	15	period	period	NN
cord-259748-x7dq1sy4	283	16	in	in	IN
cord-259748-x7dq1sy4	283	17	their	-PRON-	PRP$
cord-259748-x7dq1sy4	283	18	lifecycle	lifecycle	NN
cord-259748-x7dq1sy4	283	19	.	.	.
cord-259748-x7dq1sy4	284	1	T.	T.	NNP
cord-259748-x7dq1sy4	284	2	gondii	gondii	NNP
cord-259748-x7dq1sy4	284	3	could	could	MD
cord-259748-x7dq1sy4	284	4	engage	engage	VB
cord-259748-x7dq1sy4	284	5	cGAS	cgas	NN
cord-259748-x7dq1sy4	284	6	-	-	HYPH
cord-259748-x7dq1sy4	284	7	STING	sting	VB
cord-259748-x7dq1sy4	284	8	exclusively	exclusively	RB
cord-259748-x7dq1sy4	284	9	(	(	-LRB-
cord-259748-x7dq1sy4	284	10	163	163	CD
cord-259748-x7dq1sy4	284	11	)	)	-RRB-
cord-259748-x7dq1sy4	284	12	.	.	.
cord-259748-x7dq1sy4	285	1	However	however	RB
cord-259748-x7dq1sy4	285	2	,	,	,
cord-259748-x7dq1sy4	285	3	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	285	4	activation	activation	NN
cord-259748-x7dq1sy4	285	5	inducing	induce	VBG
cord-259748-x7dq1sy4	285	6	ISG	ISG	NNP
cord-259748-x7dq1sy4	285	7	expression	expression	NN
cord-259748-x7dq1sy4	285	8	promotes	promote	VBZ
cord-259748-x7dq1sy4	285	9	T.	T.	NNP
cord-259748-x7dq1sy4	285	10	gondii	gondii	NNP
cord-259748-x7dq1sy4	285	11	development	development	NN
cord-259748-x7dq1sy4	285	12	independently	independently	RB
cord-259748-x7dq1sy4	285	13	of	of	IN
cord-259748-x7dq1sy4	285	14	IFN	IFN	NNP
cord-259748-x7dq1sy4	285	15	expression	expression	NN
cord-259748-x7dq1sy4	285	16	(	(	-LRB-
cord-259748-x7dq1sy4	285	17	163	163	CD
cord-259748-x7dq1sy4	285	18	)	)	-RRB-
cord-259748-x7dq1sy4	285	19	.	.	.
cord-259748-x7dq1sy4	286	1	P.	p.	NN
cord-259748-x7dq1sy4	286	2	falciparum	falciparum	NN
cord-259748-x7dq1sy4	286	3	can	can	MD
cord-259748-x7dq1sy4	286	4	target	target	VB
cord-259748-x7dq1sy4	286	5	erythrocytes	erythrocyte	NNS
cord-259748-x7dq1sy4	286	6	,	,	,
cord-259748-x7dq1sy4	286	7	lacking	lack	VBG
cord-259748-x7dq1sy4	286	8	a	a	DT
cord-259748-x7dq1sy4	286	9	nucleus	nucleus	NN
cord-259748-x7dq1sy4	286	10	and	and	CC
cord-259748-x7dq1sy4	286	11	unable	unable	JJ
cord-259748-x7dq1sy4	286	12	produce	produce	VB
cord-259748-x7dq1sy4	286	13	IFN	IFN	NNP
cord-259748-x7dq1sy4	286	14	,	,	,
cord-259748-x7dq1sy4	286	15	but	but	CC
cord-259748-x7dq1sy4	286	16	infected	infected	JJ
cord-259748-x7dq1sy4	286	17	erythrocytes	erythrocyte	NNS
cord-259748-x7dq1sy4	286	18	can	can	MD
cord-259748-x7dq1sy4	286	19	secrete	secrete	VB
cord-259748-x7dq1sy4	286	20	EVs	ev	NNS
cord-259748-x7dq1sy4	286	21	containing	contain	VBG
cord-259748-x7dq1sy4	286	22	parasitic	parasitic	JJ
cord-259748-x7dq1sy4	286	23	gDNA	gDNA	NNS
cord-259748-x7dq1sy4	286	24	to	to	IN
cord-259748-x7dq1sy4	286	25	monocytes	monocyte	NNS
cord-259748-x7dq1sy4	286	26	and	and	CC
cord-259748-x7dq1sy4	286	27	trigger	trigger	NN
cord-259748-x7dq1sy4	286	28	cGAS	cgas	NN
cord-259748-x7dq1sy4	286	29	(	(	-LRB-
cord-259748-x7dq1sy4	286	30	164	164	CD
cord-259748-x7dq1sy4	286	31	)	)	-RRB-
cord-259748-x7dq1sy4	286	32	.	.	.
cord-259748-x7dq1sy4	287	1	The	the	DT
cord-259748-x7dq1sy4	287	2	immune	immune	JJ
cord-259748-x7dq1sy4	287	3	system	system	NN
cord-259748-x7dq1sy4	287	4	is	be	VBZ
cord-259748-x7dq1sy4	287	5	regulated	regulate	VBN
cord-259748-x7dq1sy4	287	6	by	by	IN
cord-259748-x7dq1sy4	287	7	a	a	DT
cord-259748-x7dq1sy4	287	8	complicated	complicated	JJ
cord-259748-x7dq1sy4	287	9	network	network	NN
cord-259748-x7dq1sy4	287	10	.	.	.
cord-259748-x7dq1sy4	288	1	Disorder	disorder	NN
cord-259748-x7dq1sy4	288	2	of	of	IN
cord-259748-x7dq1sy4	288	3	immune	immune	JJ
cord-259748-x7dq1sy4	288	4	signaling	signaling	NN
cord-259748-x7dq1sy4	288	5	can	can	MD
cord-259748-x7dq1sy4	288	6	elicit	elicit	VB
cord-259748-x7dq1sy4	288	7	non	non	JJ
cord-259748-x7dq1sy4	288	8	-	-	JJ
cord-259748-x7dq1sy4	288	9	infectious	infectious	JJ
cord-259748-x7dq1sy4	288	10	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	288	11	or	or	CC
cord-259748-x7dq1sy4	288	12	autoimmune	autoimmune	JJ
cord-259748-x7dq1sy4	288	13	diseases	disease	NNS
cord-259748-x7dq1sy4	288	14	.	.	.
cord-259748-x7dq1sy4	289	1	Excessive	excessive	JJ
cord-259748-x7dq1sy4	289	2	,	,	,
cord-259748-x7dq1sy4	289	3	uncontrolled	uncontrolled	JJ
cord-259748-x7dq1sy4	289	4	production	production	NN
cord-259748-x7dq1sy4	289	5	of	of	IN
cord-259748-x7dq1sy4	289	6	type	type	NN
cord-259748-x7dq1sy4	290	1	-I	-I	NFP
cord-259748-x7dq1sy4	290	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	290	3	can	can	MD
cord-259748-x7dq1sy4	290	4	lead	lead	VB
cord-259748-x7dq1sy4	290	5	to	to	IN
cord-259748-x7dq1sy4	290	6	a	a	DT
cord-259748-x7dq1sy4	290	7	spectrum	spectrum	NN
cord-259748-x7dq1sy4	290	8	of	of	IN
cord-259748-x7dq1sy4	290	9	inflammation	inflammation	NN
cord-259748-x7dq1sy4	290	10	diseases	disease	NNS
cord-259748-x7dq1sy4	290	11	termed	term	VBN
cord-259748-x7dq1sy4	290	12	"	"	``
cord-259748-x7dq1sy4	290	13	type	type	NN
cord-259748-x7dq1sy4	290	14	-	-	:
cord-259748-x7dq1sy4	290	15	I	-PRON-	PRP
cord-259748-x7dq1sy4	290	16	interferonopathies	interferonopathie	NNS
cord-259748-x7dq1sy4	290	17	,	,	,
cord-259748-x7dq1sy4	290	18	"	"	''
cord-259748-x7dq1sy4	290	19	which	which	WDT
cord-259748-x7dq1sy4	290	20	have	have	VBP
cord-259748-x7dq1sy4	290	21	some	some	DT
cord-259748-x7dq1sy4	290	22	common	common	JJ
cord-259748-x7dq1sy4	290	23	manifestations	manifestation	NNS
cord-259748-x7dq1sy4	290	24	(	(	-LRB-
cord-259748-x7dq1sy4	290	25	165	165	CD
cord-259748-x7dq1sy4	290	26	)	)	-RRB-
cord-259748-x7dq1sy4	290	27	.	.	.
cord-259748-x7dq1sy4	291	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	291	2	-	-	:
cord-259748-x7dq1sy4	291	3	STING	sting	NN
cord-259748-x7dq1sy4	291	4	is	be	VBZ
cord-259748-x7dq1sy4	291	5	the	the	DT
cord-259748-x7dq1sy4	291	6	one	one	CD
cord-259748-x7dq1sy4	291	7	of	of	IN
cord-259748-x7dq1sy4	291	8	main	main	JJ
cord-259748-x7dq1sy4	291	9	sources	source	NNS
cord-259748-x7dq1sy4	291	10	of	of	IN
cord-259748-x7dq1sy4	291	11	type	type	NN
cord-259748-x7dq1sy4	291	12	-	-	:
cord-259748-x7dq1sy4	291	13	I	-PRON-	PRP
cord-259748-x7dq1sy4	291	14	IFN	IFN	NNP
cord-259748-x7dq1sy4	291	15	,	,	,
cord-259748-x7dq1sy4	291	16	acts	act	VBZ
cord-259748-x7dq1sy4	291	17	as	as	IN
cord-259748-x7dq1sy4	291	18	a	a	DT
cord-259748-x7dq1sy4	291	19	cellular	cellular	JJ
cord-259748-x7dq1sy4	291	20	immune	immune	NN
cord-259748-x7dq1sy4	291	21	-	-	HYPH
cord-259748-x7dq1sy4	291	22	sensing	sensing	NN
cord-259748-x7dq1sy4	291	23	signaling	signal	VBG
cord-259748-x7dq1sy4	291	24	axis	axis	NN
cord-259748-x7dq1sy4	291	25	,	,	,
cord-259748-x7dq1sy4	291	26	and	and	CC
cord-259748-x7dq1sy4	291	27	is	be	VBZ
cord-259748-x7dq1sy4	291	28	involved	involve	VBN
cord-259748-x7dq1sy4	291	29	in	in	IN
cord-259748-x7dq1sy4	291	30	type	type	NN
cord-259748-x7dq1sy4	291	31	-	-	:
cord-259748-x7dq1sy4	291	32	I	-PRON-	PRP
cord-259748-x7dq1sy4	291	33	interferonopathies	interferonopathie	NNS
cord-259748-x7dq1sy4	291	34	.	.	.
cord-259748-x7dq1sy4	292	1	Stimulator	Stimulator	NNP
cord-259748-x7dq1sy4	292	2	of	of	IN
cord-259748-x7dq1sy4	292	3	interferon	interferon	NN
cord-259748-x7dq1sy4	292	4	genes	gene	NNS
cord-259748-x7dq1sy4	292	5	-associated	-associate	VBD
cord-259748-x7dq1sy4	292	6	vasculopathy	vasculopathy	NNP
cord-259748-x7dq1sy4	292	7	with	with	IN
cord-259748-x7dq1sy4	292	8	onset	onset	NN
cord-259748-x7dq1sy4	292	9	in	in	IN
cord-259748-x7dq1sy4	292	10	infancy	infancy	NN
cord-259748-x7dq1sy4	292	11	(	(	-LRB-
cord-259748-x7dq1sy4	292	12	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	292	13	)	)	-RRB-
cord-259748-x7dq1sy4	292	14	is	be	VBZ
cord-259748-x7dq1sy4	292	15	a	a	DT
cord-259748-x7dq1sy4	292	16	typical	typical	JJ
cord-259748-x7dq1sy4	292	17	STING	sting	NN
cord-259748-x7dq1sy4	292	18	-	-	HYPH
cord-259748-x7dq1sy4	292	19	related	relate	VBN
cord-259748-x7dq1sy4	292	20	hereditary	hereditary	JJ
cord-259748-x7dq1sy4	292	21	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	292	22	type	type	NN
cord-259748-x7dq1sy4	292	23	-	-	:
cord-259748-x7dq1sy4	292	24	I	-PRON-	PRP
cord-259748-x7dq1sy4	292	25	interferonopathy	interferonopathy	NN
cord-259748-x7dq1sy4	292	26	,	,	,
cord-259748-x7dq1sy4	292	27	and	and	CC
cord-259748-x7dq1sy4	292	28	is	be	VBZ
cord-259748-x7dq1sy4	292	29	manifested	manifest	VBN
cord-259748-x7dq1sy4	292	30	by	by	IN
cord-259748-x7dq1sy4	292	31	interstitial	interstitial	JJ
cord-259748-x7dq1sy4	292	32	lung	lung	NN
cord-259748-x7dq1sy4	292	33	disease	disease	NN
cord-259748-x7dq1sy4	292	34	,	,	,
cord-259748-x7dq1sy4	292	35	dermatomyositis	dermatomyositis	NNP
cord-259748-x7dq1sy4	292	36	and	and	CC
cord-259748-x7dq1sy4	292	37	arthritis	arthritis	NN
cord-259748-x7dq1sy4	292	38	.	.	.
cord-259748-x7dq1sy4	293	1	Its	-PRON-	PRP$
cord-259748-x7dq1sy4	293	2	pathology	pathology	NN
cord-259748-x7dq1sy4	293	3	is	be	VBZ
cord-259748-x7dq1sy4	293	4	featured	feature	VBN
cord-259748-x7dq1sy4	293	5	by	by	IN
cord-259748-x7dq1sy4	293	6	leukocytoclastic	leukocytoclastic	JJ
cord-259748-x7dq1sy4	293	7	vasculitis	vasculitis	NN
cord-259748-x7dq1sy4	293	8	and	and	CC
cord-259748-x7dq1sy4	293	9	microthrombotic	microthrombotic	NNP
cord-259748-x7dq1sy4	293	10	angiopathy	angiopathy	NNP
cord-259748-x7dq1sy4	293	11	of	of	IN
cord-259748-x7dq1sy4	293	12	small	small	JJ
cord-259748-x7dq1sy4	293	13	dermal	dermal	JJ
cord-259748-x7dq1sy4	293	14	vessels	vessel	NNS
cord-259748-x7dq1sy4	293	15	(	(	-LRB-
cord-259748-x7dq1sy4	293	16	166	166	CD
cord-259748-x7dq1sy4	293	17	,	,	,
cord-259748-x7dq1sy4	293	18	167	167	CD
cord-259748-x7dq1sy4	293	19	)	)	-RRB-
cord-259748-x7dq1sy4	294	1	and	and	CC
cord-259748-x7dq1sy4	294	2	patients	patient	NNS
cord-259748-x7dq1sy4	294	3	can	can	MD
cord-259748-x7dq1sy4	294	4	also	also	RB
cord-259748-x7dq1sy4	294	5	suffer	suffer	VB
cord-259748-x7dq1sy4	294	6	from	from	IN
cord-259748-x7dq1sy4	294	7	lymphopenia	lymphopenia	NNP
cord-259748-x7dq1sy4	294	8	(	(	-LRB-
cord-259748-x7dq1sy4	294	9	166	166	CD
cord-259748-x7dq1sy4	294	10	)	)	-RRB-
cord-259748-x7dq1sy4	294	11	(	(	-LRB-
cord-259748-x7dq1sy4	294	12	167	167	CD
cord-259748-x7dq1sy4	294	13	)	)	-RRB-
cord-259748-x7dq1sy4	294	14	(	(	-LRB-
cord-259748-x7dq1sy4	294	15	168	168	CD
cord-259748-x7dq1sy4	294	16	)	)	-RRB-
cord-259748-x7dq1sy4	294	17	(	(	-LRB-
cord-259748-x7dq1sy4	294	18	169	169	CD
cord-259748-x7dq1sy4	294	19	)	)	-RRB-
cord-259748-x7dq1sy4	294	20	.	.	.
cord-259748-x7dq1sy4	295	1	The	the	DT
cord-259748-x7dq1sy4	295	2	etiology	etiology	NN
cord-259748-x7dq1sy4	295	3	of	of	IN
cord-259748-x7dq1sy4	295	4	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	295	5	is	be	VBZ
cord-259748-x7dq1sy4	295	6	a	a	DT
cord-259748-x7dq1sy4	295	7	gain	gain	NN
cord-259748-x7dq1sy4	295	8	of	of	IN
cord-259748-x7dq1sy4	295	9	function	function	NN
cord-259748-x7dq1sy4	295	10	(	(	-LRB-
cord-259748-x7dq1sy4	295	11	GOF	GOF	NNP
cord-259748-x7dq1sy4	295	12	)	)	-RRB-
cord-259748-x7dq1sy4	295	13	mutant	mutant	NN
cord-259748-x7dq1sy4	295	14	in	in	IN
cord-259748-x7dq1sy4	295	15	STING	sting	NN
cord-259748-x7dq1sy4	295	16	which	which	WDT
cord-259748-x7dq1sy4	295	17	leads	lead	VBZ
cord-259748-x7dq1sy4	295	18	to	to	IN
cord-259748-x7dq1sy4	295	19	constitutive	constitutive	JJ
cord-259748-x7dq1sy4	295	20	STING	sting	NN
cord-259748-x7dq1sy4	295	21	activation	activation	NN
cord-259748-x7dq1sy4	295	22	without	without	IN
cord-259748-x7dq1sy4	295	23	CDNs	CDNs	NNP
cord-259748-x7dq1sy4	295	24	stimulation	stimulation	NN
cord-259748-x7dq1sy4	295	25	(	(	-LRB-
cord-259748-x7dq1sy4	295	26	166	166	CD
cord-259748-x7dq1sy4	295	27	)	)	-RRB-
cord-259748-x7dq1sy4	295	28	.	.	.
cord-259748-x7dq1sy4	296	1	Currently	currently	RB
cord-259748-x7dq1sy4	296	2	,	,	,
cord-259748-x7dq1sy4	296	3	several	several	JJ
cord-259748-x7dq1sy4	296	4	mutant	mutant	JJ
cord-259748-x7dq1sy4	296	5	amino	amino	NN
cord-259748-x7dq1sy4	296	6	acids	acid	NNS
cord-259748-x7dq1sy4	296	7	residues	residue	NNS
cord-259748-x7dq1sy4	296	8	have	have	VBP
cord-259748-x7dq1sy4	296	9	been	be	VBN
cord-259748-x7dq1sy4	296	10	found	find	VBN
cord-259748-x7dq1sy4	296	11	in	in	IN
cord-259748-x7dq1sy4	296	12	or	or	CC
cord-259748-x7dq1sy4	296	13	close	close	RB
cord-259748-x7dq1sy4	296	14	to	to	IN
cord-259748-x7dq1sy4	296	15	the	the	DT
cord-259748-x7dq1sy4	296	16	dimerization	dimerization	NN
cord-259748-x7dq1sy4	296	17	domain	domain	NN
cord-259748-x7dq1sy4	296	18	(	(	-LRB-
cord-259748-x7dq1sy4	296	19	V155	V155	NNP
cord-259748-x7dq1sy4	296	20	M	M	NNP
cord-259748-x7dq1sy4	296	21	,	,	,
cord-259748-x7dq1sy4	296	22	N154S	N154S	NNP
cord-259748-x7dq1sy4	296	23	,	,	,
cord-259748-x7dq1sy4	296	24	G166E	G166E	NNP
cord-259748-x7dq1sy4	296	25	,	,	,
cord-259748-x7dq1sy4	296	26	V147L	V147L	NNP
cord-259748-x7dq1sy4	296	27	,	,	,
cord-259748-x7dq1sy4	296	28	and	and	CC
cord-259748-x7dq1sy4	296	29	V147	V147	NNP
cord-259748-x7dq1sy4	296	30	M	M	NNP
cord-259748-x7dq1sy4	296	31	)	)	-RRB-
cord-259748-x7dq1sy4	296	32	(	(	-LRB-
cord-259748-x7dq1sy4	296	33	64	64	CD
cord-259748-x7dq1sy4	296	34	,	,	,
cord-259748-x7dq1sy4	296	35	166	166	CD
cord-259748-x7dq1sy4	296	36	,	,	,
cord-259748-x7dq1sy4	296	37	168	168	CD
cord-259748-x7dq1sy4	296	38	,	,	,
cord-259748-x7dq1sy4	296	39	170	170	CD
cord-259748-x7dq1sy4	296	40	)	)	-RRB-
cord-259748-x7dq1sy4	296	41	,	,	,
cord-259748-x7dq1sy4	296	42	as	as	RB
cord-259748-x7dq1sy4	296	43	well	well	RB
cord-259748-x7dq1sy4	296	44	as	as	IN
cord-259748-x7dq1sy4	296	45	R284	R284	NNS
cord-259748-x7dq1sy4	296	46	G	G	NNP
cord-259748-x7dq1sy4	296	47	,	,	,
cord-259748-x7dq1sy4	296	48	R284S	R284S	NNP
cord-259748-x7dq1sy4	296	49	,	,	,
cord-259748-x7dq1sy4	296	50	R281Q	R281Q	NNP
cord-259748-x7dq1sy4	296	51	,	,	,
cord-259748-x7dq1sy4	296	52	and	and	CC
cord-259748-x7dq1sy4	296	53	C206Y	c206y	NN
cord-259748-x7dq1sy4	296	54	in	in	IN
cord-259748-x7dq1sy4	296	55	the	the	DT
cord-259748-x7dq1sy4	296	56	cGAMP	cgamp	NN
cord-259748-x7dq1sy4	296	57	-	-	HYPH
cord-259748-x7dq1sy4	296	58	binding	bind	VBG
cord-259748-x7dq1sy4	296	59	domain	domain	NN
cord-259748-x7dq1sy4	296	60	(	(	-LRB-
cord-259748-x7dq1sy4	296	61	171	171	CD
cord-259748-x7dq1sy4	296	62	)	)	-RRB-
cord-259748-x7dq1sy4	296	63	.	.	.
cord-259748-x7dq1sy4	297	1	Other	other	JJ
cord-259748-x7dq1sy4	297	2	types	type	NNS
cord-259748-x7dq1sy4	297	3	of	of	IN
cord-259748-x7dq1sy4	297	4	type	type	NN
cord-259748-x7dq1sy4	297	5	-	-	:
cord-259748-x7dq1sy4	297	6	I	-PRON-	PRP
cord-259748-x7dq1sy4	297	7	interferonopathies	interferonopathie	NNS
cord-259748-x7dq1sy4	297	8	,	,	,
cord-259748-x7dq1sy4	297	9	such	such	JJ
cord-259748-x7dq1sy4	297	10	as	as	IN
cord-259748-x7dq1sy4	297	11	systemic	systemic	JJ
cord-259748-x7dq1sy4	297	12	lupus	lupus	NN
cord-259748-x7dq1sy4	297	13	erythematosus	erythematosus	NN
cord-259748-x7dq1sy4	297	14	(	(	-LRB-
cord-259748-x7dq1sy4	297	15	SLE	SLE	NNP
cord-259748-x7dq1sy4	297	16	)	)	-RRB-
cord-259748-x7dq1sy4	297	17	and	and	CC
cord-259748-x7dq1sy4	297	18	Aicardi	Aicardi	NNPS
cord-259748-x7dq1sy4	297	19	-	-	HYPH
cord-259748-x7dq1sy4	297	20	Goutières	Goutières	NNP
cord-259748-x7dq1sy4	297	21	syndrome	syndrome	NN
cord-259748-x7dq1sy4	297	22	(	(	-LRB-
cord-259748-x7dq1sy4	297	23	AGS	AGS	NNP
cord-259748-x7dq1sy4	297	24	)	)	-RRB-
cord-259748-x7dq1sy4	297	25	,	,	,
cord-259748-x7dq1sy4	297	26	have	have	VBP
cord-259748-x7dq1sy4	297	27	relationships	relationship	NNS
cord-259748-x7dq1sy4	297	28	with	with	IN
cord-259748-x7dq1sy4	297	29	defective	defective	JJ
cord-259748-x7dq1sy4	297	30	clearance	clearance	NN
cord-259748-x7dq1sy4	297	31	of	of	IN
cord-259748-x7dq1sy4	297	32	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	297	33	nucleic	nucleic	JJ
cord-259748-x7dq1sy4	297	34	acids	acid	NNS
cord-259748-x7dq1sy4	297	35	caused	cause	VBN
cord-259748-x7dq1sy4	297	36	by	by	IN
cord-259748-x7dq1sy4	297	37	congenital	congenital	JJ
cord-259748-x7dq1sy4	297	38	dysfunction	dysfunction	NN
cord-259748-x7dq1sy4	297	39	of	of	IN
cord-259748-x7dq1sy4	297	40	TREX1	TREX1	NNP
cord-259748-x7dq1sy4	297	41	,	,	,
cord-259748-x7dq1sy4	297	42	RNASEH2	RNASEH2	NNP
cord-259748-x7dq1sy4	297	43	,	,	,
cord-259748-x7dq1sy4	297	44	and	and	CC
cord-259748-x7dq1sy4	297	45	SAMHD1	SAMHD1	NNS
cord-259748-x7dq1sy4	297	46	.	.	.
cord-259748-x7dq1sy4	298	1	SLE	SLE	NNP
cord-259748-x7dq1sy4	298	2	is	be	VBZ
cord-259748-x7dq1sy4	298	3	a	a	DT
cord-259748-x7dq1sy4	298	4	heterogeneous	heterogeneous	JJ
cord-259748-x7dq1sy4	298	5	autoimmune	autoimmune	JJ
cord-259748-x7dq1sy4	298	6	disease	disease	NN
cord-259748-x7dq1sy4	298	7	which	which	WDT
cord-259748-x7dq1sy4	298	8	has	have	VBZ
cord-259748-x7dq1sy4	298	9	prominent	prominent	JJ
cord-259748-x7dq1sy4	298	10	type	type	NN
cord-259748-x7dq1sy4	298	11	-	-	:
cord-259748-x7dq1sy4	298	12	I	i	NN
cord-259748-x7dq1sy4	298	13	and	and	CC
cord-259748-x7dq1sy4	298	14	also	also	RB
cord-259748-x7dq1sy4	298	15	-II	-II	:
cord-259748-x7dq1sy4	298	16	IFN	IFN	NNP
cord-259748-x7dq1sy4	298	17	signatures	signature	NNS
cord-259748-x7dq1sy4	298	18	(	(	-LRB-
cord-259748-x7dq1sy4	298	19	172	172	CD
cord-259748-x7dq1sy4	298	20	)	)	-RRB-
cord-259748-x7dq1sy4	298	21	.	.	.
cord-259748-x7dq1sy4	299	1	AGS	AGS	NNP
cord-259748-x7dq1sy4	299	2	comprises	comprise	VBZ
cord-259748-x7dq1sy4	299	3	some	some	DT
cord-259748-x7dq1sy4	299	4	systemic	systemic	JJ
cord-259748-x7dq1sy4	299	5	autoimmune	autoimmune	JJ
cord-259748-x7dq1sy4	299	6	syndromes	syndrome	NNS
cord-259748-x7dq1sy4	299	7	overlapping	overlap	VBG
cord-259748-x7dq1sy4	299	8	with	with	IN
cord-259748-x7dq1sy4	299	9	SLE	SLE	NNP
cord-259748-x7dq1sy4	299	10	,	,	,
cord-259748-x7dq1sy4	299	11	and	and	CC
cord-259748-x7dq1sy4	299	12	can	can	MD
cord-259748-x7dq1sy4	299	13	be	be	VB
cord-259748-x7dq1sy4	299	14	classified	classify	VBN
cord-259748-x7dq1sy4	299	15	as	as	IN
cord-259748-x7dq1sy4	299	16	a	a	DT
cord-259748-x7dq1sy4	299	17	"	"	``
cord-259748-x7dq1sy4	299	18	lupuslike	lupuslike	JJ
cord-259748-x7dq1sy4	299	19	disease	disease	NN
cord-259748-x7dq1sy4	299	20	"	"	''
cord-259748-x7dq1sy4	299	21	(	(	-LRB-
cord-259748-x7dq1sy4	299	22	173	173	CD
cord-259748-x7dq1sy4	299	23	)	)	-RRB-
cord-259748-x7dq1sy4	299	24	.	.	.
cord-259748-x7dq1sy4	300	1	Additionally	additionally	RB
cord-259748-x7dq1sy4	300	2	,	,	,
cord-259748-x7dq1sy4	300	3	AGS	AGS	NNP
cord-259748-x7dq1sy4	300	4	also	also	RB
cord-259748-x7dq1sy4	300	5	causes	cause	VBZ
cord-259748-x7dq1sy4	300	6	severe	severe	JJ
cord-259748-x7dq1sy4	300	7	developmental	developmental	JJ
cord-259748-x7dq1sy4	300	8	neurological	neurological	JJ
cord-259748-x7dq1sy4	300	9	disorders	disorder	NNS
cord-259748-x7dq1sy4	300	10	,	,	,
cord-259748-x7dq1sy4	300	11	including	include	VBG
cord-259748-x7dq1sy4	300	12	cerebral	cerebral	JJ
cord-259748-x7dq1sy4	300	13	calcifications	calcification	NNS
cord-259748-x7dq1sy4	300	14	,	,	,
cord-259748-x7dq1sy4	300	15	encephalopathy	encephalopathy	NN
cord-259748-x7dq1sy4	300	16	and	and	CC
cord-259748-x7dq1sy4	300	17	cerebral	cerebral	JJ
cord-259748-x7dq1sy4	300	18	atrophy	atrophy	NN
cord-259748-x7dq1sy4	300	19	.	.	.
cord-259748-x7dq1sy4	301	1	Systemic	systemic	JJ
cord-259748-x7dq1sy4	301	2	lupus	lupus	NN
cord-259748-x7dq1sy4	301	3	erythematosus	erythematosus	NN
cord-259748-x7dq1sy4	301	4	is	be	VBZ
cord-259748-x7dq1sy4	301	5	a	a	DT
cord-259748-x7dq1sy4	301	6	representative	representative	JJ
cord-259748-x7dq1sy4	301	7	model	model	NN
cord-259748-x7dq1sy4	301	8	for	for	IN
cord-259748-x7dq1sy4	301	9	elucidating	elucidate	VBG
cord-259748-x7dq1sy4	301	10	the	the	DT
cord-259748-x7dq1sy4	301	11	mechanism	mechanism	NN
cord-259748-x7dq1sy4	301	12	of	of	IN
cord-259748-x7dq1sy4	301	13	type	type	NN
cord-259748-x7dq1sy4	301	14	-	-	:
cord-259748-x7dq1sy4	301	15	I	-PRON-	PRP
cord-259748-x7dq1sy4	301	16	interferonopathies	interferonopathie	NNS
cord-259748-x7dq1sy4	301	17	.	.	.
cord-259748-x7dq1sy4	302	1	In	in	IN
cord-259748-x7dq1sy4	302	2	SLE	SLE	NNP
cord-259748-x7dq1sy4	302	3	,	,	,
cord-259748-x7dq1sy4	302	4	the	the	DT
cord-259748-x7dq1sy4	302	5	level	level	NN
cord-259748-x7dq1sy4	302	6	of	of	IN
cord-259748-x7dq1sy4	302	7	self	self	NN
cord-259748-x7dq1sy4	302	8	-	-	HYPH
cord-259748-x7dq1sy4	302	9	DNA	dna	NN
cord-259748-x7dq1sy4	302	10	which	which	WDT
cord-259748-x7dq1sy4	302	11	is	be	VBZ
cord-259748-x7dq1sy4	302	12	packaged	package	VBN
cord-259748-x7dq1sy4	302	13	into	into	IN
cord-259748-x7dq1sy4	302	14	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	302	15	-	-	HYPH
cord-259748-x7dq1sy4	302	16	derived	derive	VBN
cord-259748-x7dq1sy4	302	17	membrane	membrane	NN
cord-259748-x7dq1sy4	302	18	vesicles	vesicle	NNS
cord-259748-x7dq1sy4	302	19	along	along	IN
cord-259748-x7dq1sy4	302	20	with	with	IN
cord-259748-x7dq1sy4	302	21	the	the	DT
cord-259748-x7dq1sy4	302	22	level	level	NN
cord-259748-x7dq1sy4	302	23	of	of	IN
cord-259748-x7dq1sy4	302	24	anti	anti	JJ
cord-259748-x7dq1sy4	302	25	-	-	JJ
cord-259748-x7dq1sy4	302	26	dsDNA	dsdna	JJ
cord-259748-x7dq1sy4	302	27	antibody	antibody	NN
cord-259748-x7dq1sy4	302	28	is	be	VBZ
cord-259748-x7dq1sy4	302	29	increased	increase	VBN
cord-259748-x7dq1sy4	302	30	in	in	IN
cord-259748-x7dq1sy4	302	31	the	the	DT
cord-259748-x7dq1sy4	302	32	serum	serum	NN
cord-259748-x7dq1sy4	302	33	of	of	IN
cord-259748-x7dq1sy4	302	34	patients	patient	NNS
cord-259748-x7dq1sy4	302	35	(	(	-LRB-
cord-259748-x7dq1sy4	302	36	174	174	CD
cord-259748-x7dq1sy4	302	37	)	)	-RRB-
cord-259748-x7dq1sy4	302	38	.	.	.
cord-259748-x7dq1sy4	303	1	A	a	DT
cord-259748-x7dq1sy4	303	2	study	study	NN
cord-259748-x7dq1sy4	303	3	revealed	reveal	VBD
cord-259748-x7dq1sy4	303	4	increasing	increase	VBG
cord-259748-x7dq1sy4	303	5	levels	level	NNS
cord-259748-x7dq1sy4	303	6	of	of	IN
cord-259748-x7dq1sy4	303	7	ISGs	isg	NNS
cord-259748-x7dq1sy4	303	8	(	(	-LRB-
cord-259748-x7dq1sy4	303	9	including	include	VBG
cord-259748-x7dq1sy4	303	10	cGAS	cgas	JJ
cord-259748-x7dq1sy4	303	11	/	/	SYM
cord-259748-x7dq1sy4	303	12	STING	sting	VB
cord-259748-x7dq1sy4	303	13	)	)	-RRB-
cord-259748-x7dq1sy4	303	14	as	as	RB
cord-259748-x7dq1sy4	303	15	well	well	RB
cord-259748-x7dq1sy4	303	16	as	as	IN
cord-259748-x7dq1sy4	303	17	the	the	DT
cord-259748-x7dq1sy4	303	18	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	303	19	-	-	HYPH
cord-259748-x7dq1sy4	303	20	detected	detect	VBN
cord-259748-x7dq1sy4	303	21	ratio	ratio	NN
cord-259748-x7dq1sy4	303	22	in	in	IN
cord-259748-x7dq1sy4	303	23	peripheral	peripheral	JJ
cord-259748-x7dq1sy4	303	24	-	-	HYPH
cord-259748-x7dq1sy4	303	25	blood	blood	NN
cord-259748-x7dq1sy4	303	26	mononuclear	mononuclear	NN
cord-259748-x7dq1sy4	303	27	cells	cell	NNS
cord-259748-x7dq1sy4	303	28	of	of	IN
cord-259748-x7dq1sy4	303	29	SLE	SLE	NNP
cord-259748-x7dq1sy4	303	30	patients	patient	NNS
cord-259748-x7dq1sy4	303	31	(	(	-LRB-
cord-259748-x7dq1sy4	303	32	175	175	CD
cord-259748-x7dq1sy4	303	33	)	)	-RRB-
cord-259748-x7dq1sy4	303	34	.	.	.
cord-259748-x7dq1sy4	304	1	As	as	IN
cord-259748-x7dq1sy4	304	2	innate	innate	JJ
cord-259748-x7dq1sy4	304	3	immune	immune	JJ
cord-259748-x7dq1sy4	304	4	cells	cell	NNS
cord-259748-x7dq1sy4	304	5	,	,	,
cord-259748-x7dq1sy4	304	6	DCs	dc	NNS
cord-259748-x7dq1sy4	304	7	have	have	VBP
cord-259748-x7dq1sy4	304	8	essential	essential	JJ
cord-259748-x7dq1sy4	304	9	roles	role	NNS
cord-259748-x7dq1sy4	304	10	in	in	IN
cord-259748-x7dq1sy4	304	11	antigen	antigen	NN
cord-259748-x7dq1sy4	304	12	presentation	presentation	NN
cord-259748-x7dq1sy4	304	13	,	,	,
cord-259748-x7dq1sy4	304	14	cytokine	cytokine	JJ
cord-259748-x7dq1sy4	304	15	secretion	secretion	NN
cord-259748-x7dq1sy4	304	16	,	,	,
cord-259748-x7dq1sy4	304	17	and	and	CC
cord-259748-x7dq1sy4	304	18	priming	prime	VBG
cord-259748-x7dq1sy4	304	19	the	the	DT
cord-259748-x7dq1sy4	304	20	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	304	21	response	response	NN
cord-259748-x7dq1sy4	304	22	of	of	IN
cord-259748-x7dq1sy4	304	23	immune	immune	JJ
cord-259748-x7dq1sy4	304	24	cells	cell	NNS
cord-259748-x7dq1sy4	304	25	(	(	-LRB-
cord-259748-x7dq1sy4	304	26	176	176	CD
cord-259748-x7dq1sy4	304	27	)	)	-RRB-
cord-259748-x7dq1sy4	304	28	.	.	.
cord-259748-x7dq1sy4	305	1	Plasmacytoid	Plasmacytoid	NNP
cord-259748-x7dq1sy4	305	2	DCs	DCs	NNP
cord-259748-x7dq1sy4	305	3	(	(	-LRB-
cord-259748-x7dq1sy4	305	4	pDCs	pDCs	NNP
cord-259748-x7dq1sy4	305	5	)	)	-RRB-
cord-259748-x7dq1sy4	305	6	can	can	MD
cord-259748-x7dq1sy4	305	7	internalize	internalize	VB
cord-259748-x7dq1sy4	305	8	and	and	CC
cord-259748-x7dq1sy4	305	9	recognize	recognize	VB
cord-259748-x7dq1sy4	305	10	self	self	NN
cord-259748-x7dq1sy4	305	11	-	-	HYPH
cord-259748-x7dq1sy4	305	12	DNA	dna	NN
cord-259748-x7dq1sy4	305	13	and	and	CC
cord-259748-x7dq1sy4	305	14	they	-PRON-	PRP
cord-259748-x7dq1sy4	305	15	are	be	VBP
cord-259748-x7dq1sy4	305	16	the	the	DT
cord-259748-x7dq1sy4	305	17	main	main	JJ
cord-259748-x7dq1sy4	305	18	source	source	NN
cord-259748-x7dq1sy4	305	19	of	of	IN
cord-259748-x7dq1sy4	305	20	type	type	NN
cord-259748-x7dq1sy4	305	21	-	-	:
cord-259748-x7dq1sy4	305	22	I	-PRON-	PRP
cord-259748-x7dq1sy4	305	23	IFN	IFN	NNP
cord-259748-x7dq1sy4	305	24	in	in	IN
cord-259748-x7dq1sy4	305	25	serum	serum	NN
cord-259748-x7dq1sy4	305	26	during	during	IN
cord-259748-x7dq1sy4	305	27	SLE	SLE	NNP
cord-259748-x7dq1sy4	305	28	(	(	-LRB-
cord-259748-x7dq1sy4	305	29	177	177	CD
cord-259748-x7dq1sy4	305	30	)	)	-RRB-
cord-259748-x7dq1sy4	305	31	.	.	.
cord-259748-x7dq1sy4	306	1	IFNα	IFNα	NNP
cord-259748-x7dq1sy4	306	2	/	/	SYM
cord-259748-x7dq1sy4	306	3	β	β	NNP
cord-259748-x7dq1sy4	306	4	is	be	VBZ
cord-259748-x7dq1sy4	306	5	essential	essential	JJ
cord-259748-x7dq1sy4	306	6	for	for	IN
cord-259748-x7dq1sy4	306	7	complete	complete	JJ
cord-259748-x7dq1sy4	306	8	function	function	NN
cord-259748-x7dq1sy4	306	9	of	of	IN
cord-259748-x7dq1sy4	306	10	immature	immature	JJ
cord-259748-x7dq1sy4	306	11	pDCs	pdcs	FW
cord-259748-x7dq1sy4	306	12	(	(	-LRB-
cord-259748-x7dq1sy4	306	13	178	178	CD
cord-259748-x7dq1sy4	306	14	)	)	-RRB-
cord-259748-x7dq1sy4	306	15	.	.	.
cord-259748-x7dq1sy4	307	1	IFNα	IFNα	NNP
cord-259748-x7dq1sy4	307	2	/	/	SYM
cord-259748-x7dq1sy4	307	3	β	β	NNP
cord-259748-x7dq1sy4	307	4	and	and	CC
cord-259748-x7dq1sy4	307	5	IL-1	IL-1	NNP
cord-259748-x7dq1sy4	307	6	can	can	MD
cord-259748-x7dq1sy4	307	7	induce	induce	VB
cord-259748-x7dq1sy4	307	8	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	307	9	oxidative	oxidative	JJ
cord-259748-x7dq1sy4	307	10	stress	stress	NN
cord-259748-x7dq1sy4	307	11	in	in	IN
cord-259748-x7dq1sy4	307	12	DCs	DCs	NNP
cord-259748-x7dq1sy4	307	13	and	and	CC
cord-259748-x7dq1sy4	307	14	decrease	decrease	VB
cord-259748-x7dq1sy4	307	15	ATP	ATP	NNP
cord-259748-x7dq1sy4	307	16	production	production	NN
cord-259748-x7dq1sy4	307	17	,	,	,
cord-259748-x7dq1sy4	307	18	which	which	WDT
cord-259748-x7dq1sy4	307	19	blocks	block	VBZ
cord-259748-x7dq1sy4	307	20	proton	proton	NN
cord-259748-x7dq1sy4	307	21	-	-	HYPH
cord-259748-x7dq1sy4	307	22	pump	pump	NN
cord-259748-x7dq1sy4	307	23	function	function	NN
cord-259748-x7dq1sy4	307	24	and	and	CC
cord-259748-x7dq1sy4	307	25	increases	increase	VBZ
cord-259748-x7dq1sy4	307	26	pH	ph	NN
cord-259748-x7dq1sy4	307	27	of	of	IN
cord-259748-x7dq1sy4	307	28	lysosomes	lysosome	NNS
cord-259748-x7dq1sy4	307	29	.	.	.
cord-259748-x7dq1sy4	308	1	This	this	DT
cord-259748-x7dq1sy4	308	2	process	process	NN
cord-259748-x7dq1sy4	308	3	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	308	4	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	308	5	degradation	degradation	NN
cord-259748-x7dq1sy4	308	6	and	and	CC
cord-259748-x7dq1sy4	308	7	blocks	block	VBZ
cord-259748-x7dq1sy4	308	8	mtDNA	mtdna	JJ
cord-259748-x7dq1sy4	308	9	clearance	clearance	NN
cord-259748-x7dq1sy4	308	10	,	,	,
cord-259748-x7dq1sy4	308	11	which	which	WDT
cord-259748-x7dq1sy4	308	12	engages	engage	VBZ
cord-259748-x7dq1sy4	308	13	the	the	DT
cord-259748-x7dq1sy4	308	14	cGAS	cgas	JJ
cord-259748-x7dq1sy4	308	15	-	-	HYPH
cord-259748-x7dq1sy4	308	16	STING	sting	NN
cord-259748-x7dq1sy4	308	17	pathway	pathway	NN
cord-259748-x7dq1sy4	308	18	(	(	-LRB-
cord-259748-x7dq1sy4	308	19	31	31	CD
cord-259748-x7dq1sy4	308	20	,	,	,
cord-259748-x7dq1sy4	308	21	179	179	CD
cord-259748-x7dq1sy4	308	22	)	)	-RRB-
cord-259748-x7dq1sy4	308	23	.	.	.
cord-259748-x7dq1sy4	309	1	Moreover	moreover	RB
cord-259748-x7dq1sy4	309	2	,	,	,
cord-259748-x7dq1sy4	309	3	monocytes	monocyte	NNS
cord-259748-x7dq1sy4	309	4	may	may	MD
cord-259748-x7dq1sy4	309	5	sense	sense	VB
cord-259748-x7dq1sy4	309	6	mtDNA	mtdna	JJ
cord-259748-x7dq1sy4	309	7	through	through	IN
cord-259748-x7dq1sy4	309	8	cGAS	cgas	JJ
cord-259748-x7dq1sy4	309	9	-	-	HYPH
cord-259748-x7dq1sy4	309	10	STING	sting	NN
cord-259748-x7dq1sy4	309	11	and	and	CC
cord-259748-x7dq1sy4	309	12	differentiate	differentiate	VB
cord-259748-x7dq1sy4	309	13	into	into	IN
cord-259748-x7dq1sy4	309	14	DCs	DCs	NNP
cord-259748-x7dq1sy4	309	15	(	(	-LRB-
cord-259748-x7dq1sy4	309	16	31	31	CD
cord-259748-x7dq1sy4	309	17	,	,	,
cord-259748-x7dq1sy4	309	18	180	180	CD
cord-259748-x7dq1sy4	309	19	)	)	-RRB-
cord-259748-x7dq1sy4	309	20	.	.	.
cord-259748-x7dq1sy4	310	1	Neutrophil	Neutrophil	NNP
cord-259748-x7dq1sy4	310	2	extracellular	extracellular	JJ
cord-259748-x7dq1sy4	310	3	traps	trap	NNS
cord-259748-x7dq1sy4	310	4	(	(	-LRB-
cord-259748-x7dq1sy4	310	5	NETs	net	NNS
cord-259748-x7dq1sy4	310	6	)	)	-RRB-
cord-259748-x7dq1sy4	310	7	are	be	VBP
cord-259748-x7dq1sy4	310	8	complexes	complex	NNS
cord-259748-x7dq1sy4	310	9	released	release	VBN
cord-259748-x7dq1sy4	310	10	by	by	IN
cord-259748-x7dq1sy4	310	11	neutrophils	neutrophil	NNS
cord-259748-x7dq1sy4	310	12	exposed	expose	VBN
cord-259748-x7dq1sy4	310	13	to	to	IN
cord-259748-x7dq1sy4	310	14	stimuli	stimulus	NNS
cord-259748-x7dq1sy4	310	15	or	or	CC
cord-259748-x7dq1sy4	310	16	autoantibody	autoantibody	NN
cord-259748-x7dq1sy4	310	17	immune	immune	JJ
cord-259748-x7dq1sy4	310	18	complexes	complex	NNS
cord-259748-x7dq1sy4	310	19	.	.	.
cord-259748-x7dq1sy4	311	1	NETs	net	NNS
cord-259748-x7dq1sy4	311	2	comprise	comprise	VBP
cord-259748-x7dq1sy4	311	3	extracellularly	extracellularly	RB
cord-259748-x7dq1sy4	311	4	released	release	VBN
cord-259748-x7dq1sy4	311	5	chromatin	chromatin	NN
cord-259748-x7dq1sy4	311	6	,	,	,
cord-259748-x7dq1sy4	311	7	myeloperoxidase	myeloperoxidase	NN
cord-259748-x7dq1sy4	311	8	enzymes	enzyme	NNS
cord-259748-x7dq1sy4	311	9	,	,	,
cord-259748-x7dq1sy4	311	10	and	and	CC
cord-259748-x7dq1sy4	311	11	also	also	RB
cord-259748-x7dq1sy4	311	12	oxidized	oxidize	VBN
cord-259748-x7dq1sy4	311	13	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	311	14	.	.	.
cord-259748-x7dq1sy4	312	1	In	in	IN
cord-259748-x7dq1sy4	312	2	lupus	lupus	NN
cord-259748-x7dq1sy4	312	3	-	-	HYPH
cord-259748-x7dq1sy4	312	4	like	like	JJ
cord-259748-x7dq1sy4	312	5	diseases	disease	NNS
cord-259748-x7dq1sy4	312	6	,	,	,
cord-259748-x7dq1sy4	312	7	NETs	net	NNS
cord-259748-x7dq1sy4	312	8	can	can	MD
cord-259748-x7dq1sy4	312	9	be	be	VB
cord-259748-x7dq1sy4	312	10	induced	induce	VBN
cord-259748-x7dq1sy4	312	11	by	by	IN
cord-259748-x7dq1sy4	312	12	IFNα	IFNα	NNP
cord-259748-x7dq1sy4	312	13	/	/	SYM
cord-259748-x7dq1sy4	312	14	β	β	NNP
cord-259748-x7dq1sy4	312	15	and	and	CC
cord-259748-x7dq1sy4	312	16	may	may	MD
cord-259748-x7dq1sy4	312	17	play	play	VB
cord-259748-x7dq1sy4	312	18	a	a	DT
cord-259748-x7dq1sy4	312	19	major	major	JJ
cord-259748-x7dq1sy4	312	20	part	part	NN
cord-259748-x7dq1sy4	312	21	in	in	IN
cord-259748-x7dq1sy4	312	22	priming	prime	VBG
cord-259748-x7dq1sy4	312	23	pDCs	pDCs	NNP
cord-259748-x7dq1sy4	312	24	(	(	-LRB-
cord-259748-x7dq1sy4	312	25	181	181	CD
cord-259748-x7dq1sy4	312	26	,	,	,
cord-259748-x7dq1sy4	312	27	182	182	CD
cord-259748-x7dq1sy4	312	28	)	)	-RRB-
cord-259748-x7dq1sy4	312	29	.	.	.
cord-259748-x7dq1sy4	313	1	All	all	DT
cord-259748-x7dq1sy4	313	2	mechanisms	mechanism	NNS
cord-259748-x7dq1sy4	313	3	stated	state	VBN
cord-259748-x7dq1sy4	313	4	above	above	IN
cord-259748-x7dq1sy4	313	5	contribute	contribute	VBP
cord-259748-x7dq1sy4	313	6	to	to	IN
cord-259748-x7dq1sy4	313	7	a	a	DT
cord-259748-x7dq1sy4	313	8	more	more	RBR
cord-259748-x7dq1sy4	313	9	aggravated	aggravated	JJ
cord-259748-x7dq1sy4	313	10	type	type	NN
cord-259748-x7dq1sy4	313	11	-	-	HYPH
cord-259748-x7dq1sy4	313	12	IIFN	IIFN	NNP
cord-259748-x7dq1sy4	313	13	response	response	NN
cord-259748-x7dq1sy4	313	14	and	and	CC
cord-259748-x7dq1sy4	313	15	exacerbate	exacerbate	VB
cord-259748-x7dq1sy4	313	16	disease	disease	NN
cord-259748-x7dq1sy4	313	17	.	.	.
cord-259748-x7dq1sy4	314	1	A	a	DT
cord-259748-x7dq1sy4	314	2	similar	similar	JJ
cord-259748-x7dq1sy4	314	3	phenomenon	phenomenon	NN
cord-259748-x7dq1sy4	314	4	can	can	MD
cord-259748-x7dq1sy4	314	5	be	be	VB
cord-259748-x7dq1sy4	314	6	observed	observe	VBN
cord-259748-x7dq1sy4	314	7	in	in	IN
cord-259748-x7dq1sy4	314	8	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	314	9	,	,	,
cord-259748-x7dq1sy4	314	10	ataxia	ataxia	NN
cord-259748-x7dq1sy4	314	11	telangiectasia	telangiectasia	NNP
cord-259748-x7dq1sy4	314	12	(	(	-LRB-
cord-259748-x7dq1sy4	314	13	AT	AT	NNP
cord-259748-x7dq1sy4	314	14	)	)	-RRB-
cord-259748-x7dq1sy4	314	15	and	and	CC
cord-259748-x7dq1sy4	314	16	Artemis	Artemis	NNP
cord-259748-x7dq1sy4	314	17	deficiency	deficiency	NN
cord-259748-x7dq1sy4	314	18	(	(	-LRB-
cord-259748-x7dq1sy4	314	19	183	183	CD
cord-259748-x7dq1sy4	314	20	)	)	-RRB-
cord-259748-x7dq1sy4	314	21	.	.	.
cord-259748-x7dq1sy4	315	1	However	however	RB
cord-259748-x7dq1sy4	315	2	,	,	,
cord-259748-x7dq1sy4	315	3	compared	compare	VBN
cord-259748-x7dq1sy4	315	4	with	with	IN
cord-259748-x7dq1sy4	315	5	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	315	6	,	,	,
cord-259748-x7dq1sy4	315	7	DCs	dc	NNS
cord-259748-x7dq1sy4	315	8	in	in	IN
cord-259748-x7dq1sy4	315	9	SLE	SLE	NNP
cord-259748-x7dq1sy4	315	10	can	can	MD
cord-259748-x7dq1sy4	315	11	prime	prime	JJ
cord-259748-x7dq1sy4	315	12	T	t	NN
cord-259748-x7dq1sy4	315	13	-	-	HYPH
cord-259748-x7dq1sy4	315	14	cell	cell	NN
cord-259748-x7dq1sy4	315	15	maturation	maturation	NN
cord-259748-x7dq1sy4	315	16	significantly	significantly	RB
cord-259748-x7dq1sy4	315	17	and	and	CC
cord-259748-x7dq1sy4	315	18	increasing	increase	VBG
cord-259748-x7dq1sy4	315	19	secretion	secretion	NN
cord-259748-x7dq1sy4	315	20	of	of	IN
cord-259748-x7dq1sy4	315	21	pro	pro	JJ
cord-259748-x7dq1sy4	315	22	-	-	JJ
cord-259748-x7dq1sy4	315	23	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	315	24	cytokines	cytokine	NNS
cord-259748-x7dq1sy4	315	25	,	,	,
cord-259748-x7dq1sy4	315	26	such	such	JJ
cord-259748-x7dq1sy4	315	27	as	as	IN
cord-259748-x7dq1sy4	315	28	IL-6	IL-6	NNP
cord-259748-x7dq1sy4	315	29	and	and	CC
cord-259748-x7dq1sy4	315	30	TNFα	TNFα	NNP
cord-259748-x7dq1sy4	315	31	can	can	MD
cord-259748-x7dq1sy4	315	32	also	also	RB
cord-259748-x7dq1sy4	315	33	lead	lead	VB
cord-259748-x7dq1sy4	315	34	to	to	IN
cord-259748-x7dq1sy4	315	35	activation	activation	NN
cord-259748-x7dq1sy4	315	36	of	of	IN
cord-259748-x7dq1sy4	315	37	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	315	38	immunity	immunity	NN
cord-259748-x7dq1sy4	315	39	(	(	-LRB-
cord-259748-x7dq1sy4	315	40	Figure	figure	NN
cord-259748-x7dq1sy4	315	41	4A	4a	CD
cord-259748-x7dq1sy4	315	42	)	)	-RRB-
cord-259748-x7dq1sy4	315	43	.	.	.
cord-259748-x7dq1sy4	316	1	The	the	DT
cord-259748-x7dq1sy4	316	2	cGAS	cgas	JJ
cord-259748-x7dq1sy4	316	3	-	-	HYPH
cord-259748-x7dq1sy4	316	4	STING	sting	NN
cord-259748-x7dq1sy4	316	5	pathway	pathway	NN
cord-259748-x7dq1sy4	316	6	can	can	MD
cord-259748-x7dq1sy4	316	7	mediate	mediate	VB
cord-259748-x7dq1sy4	316	8	systemic	systemic	JJ
cord-259748-x7dq1sy4	316	9	inflammation	inflammation	NN
cord-259748-x7dq1sy4	316	10	as	as	RB
cord-259748-x7dq1sy4	316	11	well	well	RB
cord-259748-x7dq1sy4	316	12	as	as	IN
cord-259748-x7dq1sy4	316	13	autoimmune	autoimmune	JJ
cord-259748-x7dq1sy4	316	14	activation	activation	NN
cord-259748-x7dq1sy4	316	15	.	.	.
cord-259748-x7dq1sy4	317	1	However	however	RB
cord-259748-x7dq1sy4	317	2	,	,	,
cord-259748-x7dq1sy4	317	3	it	-PRON-	PRP
cord-259748-x7dq1sy4	317	4	is	be	VBZ
cord-259748-x7dq1sy4	317	5	also	also	RB
cord-259748-x7dq1sy4	317	6	involved	involve	VBN
cord-259748-x7dq1sy4	317	7	in	in	IN
cord-259748-x7dq1sy4	317	8	the	the	DT
cord-259748-x7dq1sy4	317	9	local	local	JJ
cord-259748-x7dq1sy4	317	10	inflammation	inflammation	NN
cord-259748-x7dq1sy4	317	11	of	of	IN
cord-259748-x7dq1sy4	317	12	multiple	multiple	JJ
cord-259748-x7dq1sy4	317	13	tissues	tissue	NNS
cord-259748-x7dq1sy4	317	14	.	.	.
cord-259748-x7dq1sy4	318	1	With	with	IN
cord-259748-x7dq1sy4	318	2	regard	regard	NN
cord-259748-x7dq1sy4	318	3	to	to	IN
cord-259748-x7dq1sy4	318	4	ischemic	ischemic	JJ
cord-259748-x7dq1sy4	318	5	myocardial	myocardial	JJ
cord-259748-x7dq1sy4	318	6	infarction	infarction	NN
cord-259748-x7dq1sy4	318	7	(	(	-LRB-
cord-259748-x7dq1sy4	318	8	MI	MI	NNP
cord-259748-x7dq1sy4	318	9	)	)	-RRB-
cord-259748-x7dq1sy4	318	10	,	,	,
cord-259748-x7dq1sy4	318	11	cardiac	cardiac	JJ
cord-259748-x7dq1sy4	318	12	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	318	13	can	can	MD
cord-259748-x7dq1sy4	318	14	sense	sense	VB
cord-259748-x7dq1sy4	318	15	dying	die	VBG
cord-259748-x7dq1sy4	318	16	ruptured	ruptured	JJ
cord-259748-x7dq1sy4	318	17	cells	cell	NNS
cord-259748-x7dq1sy4	318	18	and	and	CC
cord-259748-x7dq1sy4	318	19	lead	lead	VBP
cord-259748-x7dq1sy4	318	20	to	to	IN
cord-259748-x7dq1sy4	318	21	fatal	fatal	JJ
cord-259748-x7dq1sy4	318	22	post	post	JJ
cord-259748-x7dq1sy4	318	23	-	-	JJ
cord-259748-x7dq1sy4	318	24	MI	mi	NN
cord-259748-x7dq1sy4	318	25	cardiac	cardiac	JJ
cord-259748-x7dq1sy4	318	26	inflammation	inflammation	NN
cord-259748-x7dq1sy4	318	27	,	,	,
cord-259748-x7dq1sy4	318	28	which	which	WDT
cord-259748-x7dq1sy4	318	29	is	be	VBZ
cord-259748-x7dq1sy4	318	30	reversed	reverse	VBN
cord-259748-x7dq1sy4	318	31	by	by	IN
cord-259748-x7dq1sy4	318	32	ablation	ablation	NN
cord-259748-x7dq1sy4	318	33	of	of	IN
cord-259748-x7dq1sy4	318	34	cGAS	cgas	NN
cord-259748-x7dq1sy4	318	35	/	/	SYM
cord-259748-x7dq1sy4	318	36	STING	STING	NNP
cord-259748-x7dq1sy4	318	37	/	/	SYM
cord-259748-x7dq1sy4	318	38	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	318	39	(	(	-LRB-
cord-259748-x7dq1sy4	318	40	184	184	CD
cord-259748-x7dq1sy4	318	41	,	,	,
cord-259748-x7dq1sy4	318	42	185	185	CD
cord-259748-x7dq1sy4	318	43	)	)	-RRB-
cord-259748-x7dq1sy4	318	44	.	.	.
cord-259748-x7dq1sy4	319	1	In	in	IN
cord-259748-x7dq1sy4	319	2	a	a	DT
cord-259748-x7dq1sy4	319	3	non	non	JJ
cord-259748-x7dq1sy4	319	4	-	-	JJ
cord-259748-x7dq1sy4	319	5	alcoholic	alcoholic	JJ
cord-259748-x7dq1sy4	319	6	steatohepatitis	steatohepatitis	NN
cord-259748-x7dq1sy4	319	7	(	(	-LRB-
cord-259748-x7dq1sy4	319	8	NASH	NASH	NNP
cord-259748-x7dq1sy4	319	9	)	)	-RRB-
cord-259748-x7dq1sy4	319	10	model	model	NN
cord-259748-x7dq1sy4	319	11	induced	induce	VBN
cord-259748-x7dq1sy4	319	12	by	by	IN
cord-259748-x7dq1sy4	319	13	a	a	DT
cord-259748-x7dq1sy4	319	14	methionine	methionine	NN
cord-259748-x7dq1sy4	319	15	-	-	HYPH
cord-259748-x7dq1sy4	319	16	and	and	CC
cord-259748-x7dq1sy4	319	17	choline	choline	NN
cord-259748-x7dq1sy4	319	18	-	-	HYPH
cord-259748-x7dq1sy4	319	19	deficient	deficient	JJ
cord-259748-x7dq1sy4	319	20	or	or	CC
cord-259748-x7dq1sy4	319	21	high	high	JJ
cord-259748-x7dq1sy4	319	22	-	-	HYPH
cord-259748-x7dq1sy4	319	23	fat	fat	NN
cord-259748-x7dq1sy4	319	24	diet	diet	NN
cord-259748-x7dq1sy4	319	25	,	,	,
cord-259748-x7dq1sy4	319	26	lipotoxicity	lipotoxicity	NN
cord-259748-x7dq1sy4	319	27	can	can	MD
cord-259748-x7dq1sy4	319	28	cause	cause	VB
cord-259748-x7dq1sy4	319	29	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	319	30	damage	damage	NN
cord-259748-x7dq1sy4	319	31	and	and	CC
cord-259748-x7dq1sy4	319	32	up	up	RB
cord-259748-x7dq1sy4	319	33	-	-	HYPH
cord-259748-x7dq1sy4	319	34	regulate	regulate	VB
cord-259748-x7dq1sy4	319	35	STING	sting	NN
cord-259748-x7dq1sy4	319	36	/	/	SYM
cord-259748-x7dq1sy4	319	37	IRF3	irf3	CD
cord-259748-x7dq1sy4	319	38	expression	expression	NN
cord-259748-x7dq1sy4	319	39	in	in	IN
cord-259748-x7dq1sy4	319	40	hepatocytes	hepatocyte	NNS
cord-259748-x7dq1sy4	319	41	,	,	,
cord-259748-x7dq1sy4	319	42	which	which	WDT
cord-259748-x7dq1sy4	319	43	in	in	IN
cord-259748-x7dq1sy4	319	44	turn	turn	NN
cord-259748-x7dq1sy4	319	45	promotes	promote	VBZ
cord-259748-x7dq1sy4	319	46	lipid	lipid	NN
cord-259748-x7dq1sy4	319	47	accumulation	accumulation	NN
cord-259748-x7dq1sy4	319	48	and	and	CC
cord-259748-x7dq1sy4	319	49	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	319	50	glycogen	glycogen	JJ
cord-259748-x7dq1sy4	319	51	synthesis	synthesis	NN
cord-259748-x7dq1sy4	319	52	.	.	.
cord-259748-x7dq1sy4	320	1	All	all	DT
cord-259748-x7dq1sy4	320	2	above	above	RB
cord-259748-x7dq1sy4	320	3	bring	bring	VBP
cord-259748-x7dq1sy4	320	4	out	out	RP
cord-259748-x7dq1sy4	320	5	hepatic	hepatic	JJ
cord-259748-x7dq1sy4	320	6	inflammation	inflammation	NN
cord-259748-x7dq1sy4	320	7	and	and	CC
cord-259748-x7dq1sy4	320	8	hepatocytes	hepatocyte	NNS
cord-259748-x7dq1sy4	320	9	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	320	10	(	(	-LRB-
cord-259748-x7dq1sy4	320	11	186	186	CD
cord-259748-x7dq1sy4	320	12	)	)	-RRB-
cord-259748-x7dq1sy4	320	13	.	.	.
cord-259748-x7dq1sy4	321	1	In	in	IN
cord-259748-x7dq1sy4	321	2	this	this	DT
cord-259748-x7dq1sy4	321	3	model	model	NN
cord-259748-x7dq1sy4	321	4	,	,	,
cord-259748-x7dq1sy4	321	5	mice	mouse	NNS
cord-259748-x7dq1sy4	321	6	with	with	IN
cord-259748-x7dq1sy4	321	7	deficiency	deficiency	NN
cord-259748-x7dq1sy4	321	8	of	of	IN
cord-259748-x7dq1sy4	321	9	STING	sting	NN
cord-259748-x7dq1sy4	321	10	presents	present	VBZ
cord-259748-x7dq1sy4	321	11	alleviated	alleviate	VBD
cord-259748-x7dq1sy4	321	12	insulin	insulin	NN
cord-259748-x7dq1sy4	321	13	resistance	resistance	NN
cord-259748-x7dq1sy4	321	14	and	and	CC
cord-259748-x7dq1sy4	321	15	lower	low	JJR
cord-259748-x7dq1sy4	321	16	levels	level	NNS
cord-259748-x7dq1sy4	321	17	of	of	IN
cord-259748-x7dq1sy4	321	18	low	low	JJ
cord-259748-x7dq1sy4	321	19	-	-	HYPH
cord-259748-x7dq1sy4	321	20	density	density	NN
cord-259748-x7dq1sy4	321	21	lipoprotein	lipoprotein	NN
cord-259748-x7dq1sy4	321	22	in	in	IN
cord-259748-x7dq1sy4	321	23	serum	serum	NN
cord-259748-x7dq1sy4	321	24	,	,	,
cord-259748-x7dq1sy4	321	25	and	and	CC
cord-259748-x7dq1sy4	321	26	also	also	RB
cord-259748-x7dq1sy4	321	27	decreased	decrease	VBD
cord-259748-x7dq1sy4	321	28	hepatic	hepatic	JJ
cord-259748-x7dq1sy4	321	29	inflammation	inflammation	NN
cord-259748-x7dq1sy4	321	30	and	and	CC
cord-259748-x7dq1sy4	321	31	fibrosis	fibrosis	NN
cord-259748-x7dq1sy4	321	32	/	/	SYM
cord-259748-x7dq1sy4	321	33	steatosis	steatosis	NN
cord-259748-x7dq1sy4	321	34	,	,	.
cord-259748-x7dq1sy4	322	1	in	in	IN
cord-259748-x7dq1sy4	322	2	which	which	WDT
cord-259748-x7dq1sy4	322	3	hepatic	hepatic	JJ
cord-259748-x7dq1sy4	322	4	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	322	5	/	/	SYM
cord-259748-x7dq1sy4	322	6	kupffer	kupffer	NN
cord-259748-x7dq1sy4	322	7	cells	cell	NNS
cord-259748-x7dq1sy4	322	8	may	may	MD
cord-259748-x7dq1sy4	322	9	take	take	VB
cord-259748-x7dq1sy4	322	10	a	a	DT
cord-259748-x7dq1sy4	322	11	big	big	JJ
cord-259748-x7dq1sy4	322	12	part	part	NN
cord-259748-x7dq1sy4	322	13	(	(	-LRB-
cord-259748-x7dq1sy4	322	14	187	187	CD
cord-259748-x7dq1sy4	322	15	,	,	,
cord-259748-x7dq1sy4	322	16	188	188	CD
cord-259748-x7dq1sy4	322	17	)	)	-RRB-
cord-259748-x7dq1sy4	322	18	.	.	.
cord-259748-x7dq1sy4	323	1	Lipotoxicity	Lipotoxicity	NNP
cord-259748-x7dq1sy4	323	2	can	can	MD
cord-259748-x7dq1sy4	323	3	induce	induce	VB
cord-259748-x7dq1sy4	323	4	p62	p62	NN
cord-259748-x7dq1sy4	323	5	to	to	TO
cord-259748-x7dq1sy4	323	6	be	be	VB
cord-259748-x7dq1sy4	323	7	phosphorylated	phosphorylate	VBN
cord-259748-x7dq1sy4	323	8	through	through	IN
cord-259748-x7dq1sy4	323	9	the	the	DT
cord-259748-x7dq1sy4	323	10	cGAS	cgas	JJ
cord-259748-x7dq1sy4	323	11	-	-	HYPH
cord-259748-x7dq1sy4	323	12	STING	sting	NN
cord-259748-x7dq1sy4	323	13	-	-	HYPH
cord-259748-x7dq1sy4	323	14	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	323	15	pathway	pathway	NN
cord-259748-x7dq1sy4	323	16	,	,	,
cord-259748-x7dq1sy4	323	17	which	which	WDT
cord-259748-x7dq1sy4	323	18	causes	cause	VBZ
cord-259748-x7dq1sy4	323	19	aggravated	aggravate	VBN
cord-259748-x7dq1sy4	323	20	protein	protein	NN
cord-259748-x7dq1sy4	323	21	inclusions	inclusion	NNS
cord-259748-x7dq1sy4	323	22	in	in	IN
cord-259748-x7dq1sy4	323	23	hepatocytes	hepatocyte	NNS
cord-259748-x7dq1sy4	323	24	and	and	CC
cord-259748-x7dq1sy4	323	25	it	-PRON-	PRP
cord-259748-x7dq1sy4	323	26	indicates	indicate	VBZ
cord-259748-x7dq1sy4	323	27	that	that	IN
cord-259748-x7dq1sy4	323	28	p62	p62	PRP
cord-259748-x7dq1sy4	323	29	could	could	MD
cord-259748-x7dq1sy4	323	30	be	be	VB
cord-259748-x7dq1sy4	323	31	a	a	DT
cord-259748-x7dq1sy4	323	32	biomarker	biomarker	NN
cord-259748-x7dq1sy4	323	33	for	for	IN
cord-259748-x7dq1sy4	323	34	NASH	NASH	NNP
cord-259748-x7dq1sy4	323	35	prognosis	prognosis	NN
cord-259748-x7dq1sy4	323	36	(	(	-LRB-
cord-259748-x7dq1sy4	323	37	189	189	CD
cord-259748-x7dq1sy4	323	38	)	)	-RRB-
cord-259748-x7dq1sy4	323	39	.	.	.
cord-259748-x7dq1sy4	324	1	mtDNA	mtdna	JJ
cord-259748-x7dq1sy4	324	2	-	-	HYPH
cord-259748-x7dq1sy4	324	3	dependent	dependent	JJ
cord-259748-x7dq1sy4	324	4	inflammation	inflammation	NN
cord-259748-x7dq1sy4	324	5	induced	induce	VBN
cord-259748-x7dq1sy4	324	6	by	by	IN
cord-259748-x7dq1sy4	324	7	lipotoxicity	lipotoxicity	NN
cord-259748-x7dq1sy4	324	8	also	also	RB
cord-259748-x7dq1sy4	324	9	occurs	occur	VBZ
cord-259748-x7dq1sy4	324	10	in	in	IN
cord-259748-x7dq1sy4	324	11	adipose	adipose	JJ
cord-259748-x7dq1sy4	324	12	tissue	tissue	NN
cord-259748-x7dq1sy4	324	13	and	and	CC
cord-259748-x7dq1sy4	324	14	endothelial	endothelial	JJ
cord-259748-x7dq1sy4	324	15	cells	cell	NNS
cord-259748-x7dq1sy4	324	16	of	of	IN
cord-259748-x7dq1sy4	324	17	blood	blood	NN
cord-259748-x7dq1sy4	324	18	vessels	vessel	NNS
cord-259748-x7dq1sy4	324	19	,	,	,
cord-259748-x7dq1sy4	324	20	which	which	WDT
cord-259748-x7dq1sy4	324	21	contributes	contribute	VBZ
cord-259748-x7dq1sy4	324	22	to	to	IN
cord-259748-x7dq1sy4	324	23	tissue	tissue	NN
cord-259748-x7dq1sy4	324	24	inflammation	inflammation	NN
cord-259748-x7dq1sy4	324	25	,	,	,
cord-259748-x7dq1sy4	324	26	insulin	insulin	NN
cord-259748-x7dq1sy4	324	27	resistance	resistance	NN
cord-259748-x7dq1sy4	324	28	,	,	,
cord-259748-x7dq1sy4	324	29	and	and	CC
cord-259748-x7dq1sy4	324	30	cardiovascular	cardiovascular	JJ
cord-259748-x7dq1sy4	324	31	diseases	disease	NNS
cord-259748-x7dq1sy4	324	32	(	(	-LRB-
cord-259748-x7dq1sy4	324	33	42	42	CD
cord-259748-x7dq1sy4	324	34	,	,	,
cord-259748-x7dq1sy4	324	35	190	190	CD
cord-259748-x7dq1sy4	324	36	)	)	-RRB-
cord-259748-x7dq1sy4	324	37	.	.	.
cord-259748-x7dq1sy4	325	1	In	in	IN
cord-259748-x7dq1sy4	325	2	traumatic	traumatic	JJ
cord-259748-x7dq1sy4	325	3	brain	brain	NN
cord-259748-x7dq1sy4	325	4	injury	injury	NN
cord-259748-x7dq1sy4	325	5	(	(	-LRB-
cord-259748-x7dq1sy4	325	6	TBI	TBI	NNP
cord-259748-x7dq1sy4	325	7	)	)	-RRB-
cord-259748-x7dq1sy4	325	8	,	,	,
cord-259748-x7dq1sy4	325	9	local	local	JJ
cord-259748-x7dq1sy4	325	10	injury	injury	NN
cord-259748-x7dq1sy4	325	11	initiates	initiate	VBZ
cord-259748-x7dq1sy4	325	12	breakdown	breakdown	NN
cord-259748-x7dq1sy4	325	13	of	of	IN
cord-259748-x7dq1sy4	325	14	the	the	DT
cord-259748-x7dq1sy4	325	15	blood	blood	NN
cord-259748-x7dq1sy4	325	16	-	-	HYPH
cord-259748-x7dq1sy4	325	17	brain	brain	NN
cord-259748-x7dq1sy4	325	18	barrier	barrier	NN
cord-259748-x7dq1sy4	325	19	and	and	CC
cord-259748-x7dq1sy4	325	20	global	global	JJ
cord-259748-x7dq1sy4	325	21	neuroinflammation	neuroinflammation	NN
cord-259748-x7dq1sy4	325	22	(	(	-LRB-
cord-259748-x7dq1sy4	325	23	191	191	CD
cord-259748-x7dq1sy4	325	24	)	)	-RRB-
cord-259748-x7dq1sy4	325	25	.	.	.
cord-259748-x7dq1sy4	326	1	STING	sting	NN
cord-259748-x7dq1sy4	326	2	expression	expression	NN
cord-259748-x7dq1sy4	326	3	is	be	VBZ
cord-259748-x7dq1sy4	326	4	up	up	RB
cord-259748-x7dq1sy4	326	5	-	-	HYPH
cord-259748-x7dq1sy4	326	6	regulated	regulate	VBN
cord-259748-x7dq1sy4	326	7	in	in	IN
cord-259748-x7dq1sy4	326	8	TBI	TBI	NNP
cord-259748-x7dq1sy4	326	9	and	and	CC
cord-259748-x7dq1sy4	326	10	can	can	MD
cord-259748-x7dq1sy4	326	11	lead	lead	VB
cord-259748-x7dq1sy4	326	12	to	to	IN
cord-259748-x7dq1sy4	326	13	increased	increase	VBN
cord-259748-x7dq1sy4	326	14	expression	expression	NN
cord-259748-x7dq1sy4	326	15	of	of	IN
cord-259748-x7dq1sy4	326	16	pro	pro	JJ
cord-259748-x7dq1sy4	326	17	-	-	JJ
cord-259748-x7dq1sy4	326	18	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	326	19	cytokines	cytokine	NNS
cord-259748-x7dq1sy4	326	20	and	and	CC
cord-259748-x7dq1sy4	326	21	enlargement	enlargement	NN
cord-259748-x7dq1sy4	326	22	of	of	IN
cord-259748-x7dq1sy4	326	23	secondary	secondary	JJ
cord-259748-x7dq1sy4	326	24	injury	injury	NN
cord-259748-x7dq1sy4	326	25	(	(	-LRB-
cord-259748-x7dq1sy4	326	26	192	192	CD
cord-259748-x7dq1sy4	326	27	)	)	-RRB-
cord-259748-x7dq1sy4	326	28	.	.	.
cord-259748-x7dq1sy4	327	1	Reduced	reduce	VBN
cord-259748-x7dq1sy4	327	2	autophagy	autophagy	NN
cord-259748-x7dq1sy4	327	3	-	-	HYPH
cord-259748-x7dq1sy4	327	4	associated	associate	VBN
cord-259748-x7dq1sy4	327	5	protein	protein	NN
cord-259748-x7dq1sy4	327	6	expression	expression	NN
cord-259748-x7dq1sy4	327	7	induced	induce	VBN
cord-259748-x7dq1sy4	327	8	by	by	IN
cord-259748-x7dq1sy4	327	9	STING	STING	NNP
cord-259748-x7dq1sy4	327	10	may	may	MD
cord-259748-x7dq1sy4	327	11	contribute	contribute	VB
cord-259748-x7dq1sy4	327	12	to	to	IN
cord-259748-x7dq1sy4	327	13	the	the	DT
cord-259748-x7dq1sy4	327	14	dysfunction	dysfunction	NN
cord-259748-x7dq1sy4	327	15	of	of	IN
cord-259748-x7dq1sy4	327	16	autophagy	autophagy	NN
cord-259748-x7dq1sy4	327	17	and	and	CC
cord-259748-x7dq1sy4	327	18	dampen	dampen	VB
cord-259748-x7dq1sy4	327	19	the	the	DT
cord-259748-x7dq1sy4	327	20	elimination	elimination	NN
cord-259748-x7dq1sy4	327	21	of	of	IN
cord-259748-x7dq1sy4	327	22	necrotic	necrotic	JJ
cord-259748-x7dq1sy4	327	23	tissue	tissue	NN
cord-259748-x7dq1sy4	327	24	,	,	,
cord-259748-x7dq1sy4	327	25	thereby	thereby	RB
cord-259748-x7dq1sy4	327	26	intensifying	intensify	VBG
cord-259748-x7dq1sy4	327	27	inflammation	inflammation	NN
cord-259748-x7dq1sy4	327	28	(	(	-LRB-
cord-259748-x7dq1sy4	327	29	192	192	CD
cord-259748-x7dq1sy4	327	30	)	)	-RRB-
cord-259748-x7dq1sy4	327	31	.	.	.
cord-259748-x7dq1sy4	328	1	During	during	IN
cord-259748-x7dq1sy4	328	2	silicosis	silicosis	NN
cord-259748-x7dq1sy4	328	3	,	,	,
cord-259748-x7dq1sy4	328	4	silica	silica	NN
cord-259748-x7dq1sy4	328	5	can	can	MD
cord-259748-x7dq1sy4	328	6	yield	yield	VB
cord-259748-x7dq1sy4	328	7	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	328	8	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	328	9	release	release	NN
cord-259748-x7dq1sy4	328	10	and	and	CC
cord-259748-x7dq1sy4	328	11	engage	engage	VB
cord-259748-x7dq1sy4	328	12	cGAS	cgas	NN
cord-259748-x7dq1sy4	328	13	-	-	HYPH
cord-259748-x7dq1sy4	328	14	STING	sting	NN
cord-259748-x7dq1sy4	328	15	,	,	,
cord-259748-x7dq1sy4	328	16	which	which	WDT
cord-259748-x7dq1sy4	328	17	activates	activate	VBZ
cord-259748-x7dq1sy4	328	18	DCs	DCs	NNP
cord-259748-x7dq1sy4	328	19	and	and	CC
cord-259748-x7dq1sy4	328	20	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	328	21	to	to	TO
cord-259748-x7dq1sy4	328	22	cause	cause	VB
cord-259748-x7dq1sy4	328	23	severe	severe	JJ
cord-259748-x7dq1sy4	328	24	lung	lung	NN
cord-259748-x7dq1sy4	328	25	inflammation	inflammation	NN
cord-259748-x7dq1sy4	328	26	.	.	.
cord-259748-x7dq1sy4	329	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	329	2	also	also	RB
cord-259748-x7dq1sy4	329	3	leads	lead	VBZ
cord-259748-x7dq1sy4	329	4	to	to	IN
cord-259748-x7dq1sy4	329	5	death	death	NN
cord-259748-x7dq1sy4	329	6	of	of	IN
cord-259748-x7dq1sy4	329	7	epithelial	epithelial	JJ
cord-259748-x7dq1sy4	329	8	cells	cell	NNS
cord-259748-x7dq1sy4	329	9	through	through	IN
cord-259748-x7dq1sy4	329	10	the	the	DT
cord-259748-x7dq1sy4	329	11	NLRP3	NLRP3	NNP
cord-259748-x7dq1sy4	329	12	pathway	pathway	NN
cord-259748-x7dq1sy4	329	13	and	and	CC
cord-259748-x7dq1sy4	329	14	pulmonary	pulmonary	JJ
cord-259748-x7dq1sy4	329	15	fibrosis	fibrosis	NN
cord-259748-x7dq1sy4	329	16	(	(	-LRB-
cord-259748-x7dq1sy4	329	17	193	193	CD
cord-259748-x7dq1sy4	329	18	)	)	-RRB-
cord-259748-x7dq1sy4	329	19	.	.	.
cord-259748-x7dq1sy4	330	1	Similarly	similarly	RB
cord-259748-x7dq1sy4	330	2	,	,	,
cord-259748-x7dq1sy4	330	3	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	330	4	release	release	NN
cord-259748-x7dq1sy4	330	5	in	in	IN
cord-259748-x7dq1sy4	330	6	renal	renal	JJ
cord-259748-x7dq1sy4	330	7	tubule	tubule	NN
cord-259748-x7dq1sy4	330	8	cells	cell	NNS
cord-259748-x7dq1sy4	330	9	has	have	VBZ
cord-259748-x7dq1sy4	330	10	been	be	VBN
cord-259748-x7dq1sy4	330	11	found	find	VBN
cord-259748-x7dq1sy4	330	12	to	to	TO
cord-259748-x7dq1sy4	330	13	be	be	VB
cord-259748-x7dq1sy4	330	14	associated	associate	VBN
cord-259748-x7dq1sy4	330	15	with	with	IN
cord-259748-x7dq1sy4	330	16	acute	acute	JJ
cord-259748-x7dq1sy4	330	17	kidney	kidney	NN
cord-259748-x7dq1sy4	330	18	injury	injury	NN
cord-259748-x7dq1sy4	330	19	by	by	IN
cord-259748-x7dq1sy4	330	20	cytotoxic	cytotoxic	JJ
cord-259748-x7dq1sy4	330	21	drugs	drug	NNS
cord-259748-x7dq1sy4	330	22	and	and	CC
cord-259748-x7dq1sy4	330	23	chronic	chronic	JJ
cord-259748-x7dq1sy4	330	24	renal	renal	JJ
cord-259748-x7dq1sy4	330	25	fibrosis	fibrosis	NN
cord-259748-x7dq1sy4	330	26	(	(	-LRB-
cord-259748-x7dq1sy4	330	27	194	194	CD
cord-259748-x7dq1sy4	330	28	,	,	,
cord-259748-x7dq1sy4	330	29	195	195	CD
cord-259748-x7dq1sy4	330	30	)	)	-RRB-
cord-259748-x7dq1sy4	330	31	.	.	.
cord-259748-x7dq1sy4	331	1	Neurodegenerative	neurodegenerative	JJ
cord-259748-x7dq1sy4	331	2	diseases	disease	NNS
cord-259748-x7dq1sy4	331	3	are	be	VBP
cord-259748-x7dq1sy4	331	4	correlated	correlate	VBN
cord-259748-x7dq1sy4	331	5	with	with	IN
cord-259748-x7dq1sy4	331	6	local	local	JJ
cord-259748-x7dq1sy4	331	7	inflammation	inflammation	NN
cord-259748-x7dq1sy4	331	8	(	(	-LRB-
cord-259748-x7dq1sy4	331	9	196	196	CD
cord-259748-x7dq1sy4	331	10	)	)	-RRB-
cord-259748-x7dq1sy4	331	11	.	.	.
cord-259748-x7dq1sy4	332	1	In	in	IN
cord-259748-x7dq1sy4	332	2	the	the	DT
cord-259748-x7dq1sy4	332	3	central	central	JJ
cord-259748-x7dq1sy4	332	4	nervous	nervous	JJ
cord-259748-x7dq1sy4	332	5	system	system	NN
cord-259748-x7dq1sy4	332	6	(	(	-LRB-
cord-259748-x7dq1sy4	332	7	CNS	CNS	NNP
cord-259748-x7dq1sy4	332	8	)	)	-RRB-
cord-259748-x7dq1sy4	332	9	,	,	,
cord-259748-x7dq1sy4	332	10	microglia	microglia	NNP
cord-259748-x7dq1sy4	332	11	is	be	VBZ
cord-259748-x7dq1sy4	332	12	considered	consider	VBN
cord-259748-x7dq1sy4	332	13	to	to	TO
cord-259748-x7dq1sy4	332	14	be	be	VB
cord-259748-x7dq1sy4	332	15	the	the	DT
cord-259748-x7dq1sy4	332	16	main	main	JJ
cord-259748-x7dq1sy4	332	17	source	source	NN
cord-259748-x7dq1sy4	332	18	of	of	IN
cord-259748-x7dq1sy4	332	19	cGAS	cgas	JJ
cord-259748-x7dq1sy4	332	20	-	-	HYPH
cord-259748-x7dq1sy4	332	21	STING	sting	NN
cord-259748-x7dq1sy4	332	22	-	-	HYPH
cord-259748-x7dq1sy4	332	23	dependent	dependent	JJ
cord-259748-x7dq1sy4	332	24	IFN	IFN	NNP
cord-259748-x7dq1sy4	332	25	expression	expression	NN
cord-259748-x7dq1sy4	332	26	(	(	-LRB-
cord-259748-x7dq1sy4	332	27	197	197	CD
cord-259748-x7dq1sy4	332	28	)	)	-RRB-
cord-259748-x7dq1sy4	332	29	.	.	.
cord-259748-x7dq1sy4	333	1	In	in	IN
cord-259748-x7dq1sy4	333	2	neurodegenerative	neurodegenerative	JJ
cord-259748-x7dq1sy4	333	3	diseases	disease	NNS
cord-259748-x7dq1sy4	333	4	,	,	,
cord-259748-x7dq1sy4	333	5	levels	level	NNS
cord-259748-x7dq1sy4	333	6	of	of	IN
cord-259748-x7dq1sy4	333	7	the	the	DT
cord-259748-x7dq1sy4	333	8	marker	marker	NN
cord-259748-x7dq1sy4	333	9	of	of	IN
cord-259748-x7dq1sy4	333	10	microglia	microglia	JJ
cord-259748-x7dq1sy4	333	11	activation	activation	NN
cord-259748-x7dq1sy4	333	12	-	-	HYPH
cord-259748-x7dq1sy4	333	13	cluster	cluster	NN
cord-259748-x7dq1sy4	333	14	of	of	IN
cord-259748-x7dq1sy4	333	15	differentiation	differentiation	NN
cord-259748-x7dq1sy4	333	16	68	68	CD
cord-259748-x7dq1sy4	333	17	(	(	-LRB-
cord-259748-x7dq1sy4	333	18	CD68	CD68	NNP
cord-259748-x7dq1sy4	333	19	)	)	-RRB-
cord-259748-x7dq1sy4	333	20	,	,	,
cord-259748-x7dq1sy4	333	21	and	and	CC
cord-259748-x7dq1sy4	333	22	pro	pro	JJ
cord-259748-x7dq1sy4	333	23	-	-	JJ
cord-259748-x7dq1sy4	333	24	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	333	25	cytokines	cytokine	NNS
cord-259748-x7dq1sy4	333	26	are	be	VBP
cord-259748-x7dq1sy4	333	27	increased	increase	VBN
cord-259748-x7dq1sy4	333	28	(	(	-LRB-
cord-259748-x7dq1sy4	333	29	198	198	CD
cord-259748-x7dq1sy4	333	30	)	)	-RRB-
cord-259748-x7dq1sy4	333	31	.	.	.
cord-259748-x7dq1sy4	334	1	A	a	DT
cord-259748-x7dq1sy4	334	2	significant	significant	JJ
cord-259748-x7dq1sy4	334	3	feature	feature	NN
cord-259748-x7dq1sy4	334	4	of	of	IN
cord-259748-x7dq1sy4	334	5	Parkinson	Parkinson	NNP
cord-259748-x7dq1sy4	334	6	's	's	POS
cord-259748-x7dq1sy4	334	7	disease	disease	NN
cord-259748-x7dq1sy4	334	8	(	(	-LRB-
cord-259748-x7dq1sy4	334	9	PD	PD	NNP
cord-259748-x7dq1sy4	334	10	)	)	-RRB-
cord-259748-x7dq1sy4	334	11	is	be	VBZ
cord-259748-x7dq1sy4	334	12	the	the	DT
cord-259748-x7dq1sy4	334	13	neuronal	neuronal	JJ
cord-259748-x7dq1sy4	334	14	loss	loss	NN
cord-259748-x7dq1sy4	334	15	of	of	IN
cord-259748-x7dq1sy4	334	16	cerebral	cerebral	JJ
cord-259748-x7dq1sy4	334	17	nuclei	nucleus	NNS
cord-259748-x7dq1sy4	334	18	(	(	-LRB-
cord-259748-x7dq1sy4	334	19	especially	especially	RB
cord-259748-x7dq1sy4	334	20	dopaminergic	dopaminergic	JJ
cord-259748-x7dq1sy4	334	21	neurons	neuron	NNS
cord-259748-x7dq1sy4	334	22	in	in	IN
cord-259748-x7dq1sy4	334	23	the	the	DT
cord-259748-x7dq1sy4	334	24	substantianigra	substantianigra	NNS
cord-259748-x7dq1sy4	334	25	)	)	-RRB-
cord-259748-x7dq1sy4	334	26	.	.	.
cord-259748-x7dq1sy4	335	1	Serine	serine	NN
cord-259748-x7dq1sy4	335	2	/	/	SYM
cord-259748-x7dq1sy4	335	3	threonine	threonine	NN
cord-259748-x7dq1sy4	335	4	-	-	HYPH
cord-259748-x7dq1sy4	335	5	protein	protein	NN
cord-259748-x7dq1sy4	335	6	kinase	kinase	NN
cord-259748-x7dq1sy4	335	7	PINK1	PINK1	NNP
cord-259748-x7dq1sy4	336	1	and	and	CC
cord-259748-x7dq1sy4	336	2	E3	E3	NNP
cord-259748-x7dq1sy4	336	3	ubiquitin	ubiquitin	NN
cord-259748-x7dq1sy4	336	4	-	-	HYPH
cord-259748-x7dq1sy4	336	5	protein	protein	NN
cord-259748-x7dq1sy4	336	6	ligase	ligase	NN
cord-259748-x7dq1sy4	336	7	parkin	parkin	NN
cord-259748-x7dq1sy4	336	8	are	be	VBP
cord-259748-x7dq1sy4	336	9	ubiquitinrelated	ubiquitinrelate	VBN
cord-259748-x7dq1sy4	336	10	factors	factor	NNS
cord-259748-x7dq1sy4	336	11	that	that	WDT
cord-259748-x7dq1sy4	336	12	take	take	VBP
cord-259748-x7dq1sy4	336	13	part	part	NN
cord-259748-x7dq1sy4	336	14	in	in	IN
cord-259748-x7dq1sy4	336	15	removing	remove	VBG
cord-259748-x7dq1sy4	336	16	damaged	damage	VBN
cord-259748-x7dq1sy4	336	17	mitochondria	mitochondrion	NNS
cord-259748-x7dq1sy4	336	18	by	by	IN
cord-259748-x7dq1sy4	336	19	autophagy	autophagy	NN
cord-259748-x7dq1sy4	336	20	,	,	,
cord-259748-x7dq1sy4	336	21	and	and	CC
cord-259748-x7dq1sy4	336	22	their	-PRON-	PRP$
cord-259748-x7dq1sy4	336	23	dysfunction	dysfunction	NN
cord-259748-x7dq1sy4	336	24	lead	lead	VBP
cord-259748-x7dq1sy4	336	25	to	to	IN
cord-259748-x7dq1sy4	336	26	the	the	DT
cord-259748-x7dq1sy4	336	27	early	early	JJ
cord-259748-x7dq1sy4	336	28	onset	onset	NN
cord-259748-x7dq1sy4	336	29	of	of	IN
cord-259748-x7dq1sy4	336	30	PD	PD	NNP
cord-259748-x7dq1sy4	336	31	(	(	-LRB-
cord-259748-x7dq1sy4	336	32	199	199	CD
cord-259748-x7dq1sy4	336	33	)	)	-RRB-
cord-259748-x7dq1sy4	336	34	.	.	.
cord-259748-x7dq1sy4	337	1	Parkin	Parkin	NNP
cord-259748-x7dq1sy4	337	2	−/−	−/−	NNP
cord-259748-x7dq1sy4	337	3	and	and	CC
cord-259748-x7dq1sy4	337	4	PINK1	PINK1	NNP
cord-259748-x7dq1sy4	337	5	−/−	−/−	NNP
cord-259748-x7dq1sy4	337	6	mice	mouse	NNS
cord-259748-x7dq1sy4	337	7	,	,	,
cord-259748-x7dq1sy4	337	8	following	follow	VBG
cord-259748-x7dq1sy4	337	9	exhaustive	exhaustive	JJ
cord-259748-x7dq1sy4	337	10	exercise	exercise	NN
cord-259748-x7dq1sy4	337	11	,	,	,
cord-259748-x7dq1sy4	337	12	show	show	VBP
cord-259748-x7dq1sy4	337	13	inflammation	inflammation	NN
cord-259748-x7dq1sy4	337	14	and	and	CC
cord-259748-x7dq1sy4	337	15	loss	loss	NN
cord-259748-x7dq1sy4	337	16	of	of	IN
cord-259748-x7dq1sy4	337	17	dopaminergic	dopaminergic	JJ
cord-259748-x7dq1sy4	337	18	neurons	neuron	NNS
cord-259748-x7dq1sy4	337	19	,	,	,
cord-259748-x7dq1sy4	337	20	which	which	WDT
cord-259748-x7dq1sy4	337	21	can	can	MD
cord-259748-x7dq1sy4	337	22	be	be	VB
cord-259748-x7dq1sy4	337	23	rescued	rescue	VBN
cord-259748-x7dq1sy4	337	24	by	by	IN
cord-259748-x7dq1sy4	337	25	loss	loss	NN
cord-259748-x7dq1sy4	337	26	of	of	IN
cord-259748-x7dq1sy4	337	27	STING	sting	NN
cord-259748-x7dq1sy4	337	28	(	(	-LRB-
cord-259748-x7dq1sy4	337	29	200	200	CD
cord-259748-x7dq1sy4	337	30	)	)	-RRB-
cord-259748-x7dq1sy4	337	31	.	.	.
cord-259748-x7dq1sy4	338	1	Similarly	similarly	RB
cord-259748-x7dq1sy4	338	2	,	,	,
cord-259748-x7dq1sy4	338	3	AT	AT	NNP
cord-259748-x7dq1sy4	338	4	is	be	VBZ
cord-259748-x7dq1sy4	338	5	a	a	DT
cord-259748-x7dq1sy4	338	6	genetic	genetic	JJ
cord-259748-x7dq1sy4	338	7	disease	disease	NN
cord-259748-x7dq1sy4	338	8	caused	cause	VBN
cord-259748-x7dq1sy4	338	9	by	by	IN
cord-259748-x7dq1sy4	338	10	missense	missense	NN
cord-259748-x7dq1sy4	338	11	mutation	mutation	NN
cord-259748-x7dq1sy4	338	12	of	of	IN
cord-259748-x7dq1sy4	338	13	a	a	DT
cord-259748-x7dq1sy4	338	14	DNA	dna	NN
cord-259748-x7dq1sy4	338	15	-	-	HYPH
cord-259748-x7dq1sy4	338	16	repair	repair	NN
cord-259748-x7dq1sy4	338	17	protein	protein	NN
cord-259748-x7dq1sy4	338	18	:	:	:
cord-259748-x7dq1sy4	338	19	ATM	atm	NN
cord-259748-x7dq1sy4	338	20	.	.	.
cord-259748-x7dq1sy4	339	1	AT	at	IN
cord-259748-x7dq1sy4	339	2	patients	patient	NNS
cord-259748-x7dq1sy4	339	3	usually	usually	RB
cord-259748-x7dq1sy4	339	4	show	show	VBP
cord-259748-x7dq1sy4	339	5	neurodegenerative	neurodegenerative	JJ
cord-259748-x7dq1sy4	339	6	defects	defect	NNS
cord-259748-x7dq1sy4	339	7	(	(	-LRB-
cord-259748-x7dq1sy4	339	8	especially	especially	RB
cord-259748-x7dq1sy4	339	9	ataxia	ataxia	NN
cord-259748-x7dq1sy4	339	10	)	)	-RRB-
cord-259748-x7dq1sy4	339	11	complicated	complicate	VBN
cord-259748-x7dq1sy4	339	12	with	with	IN
cord-259748-x7dq1sy4	339	13	telangiectasia	telangiectasia	NN
cord-259748-x7dq1sy4	339	14	on	on	IN
cord-259748-x7dq1sy4	339	15	their	-PRON-	PRP$
cord-259748-x7dq1sy4	339	16	eyes	eye	NNS
cord-259748-x7dq1sy4	339	17	or	or	CC
cord-259748-x7dq1sy4	339	18	body	body	NN
cord-259748-x7dq1sy4	339	19	,	,	,
cord-259748-x7dq1sy4	339	20	deficiency	deficiency	NN
cord-259748-x7dq1sy4	339	21	of	of	IN
cord-259748-x7dq1sy4	339	22	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	339	23	immune	immune	JJ
cord-259748-x7dq1sy4	339	24	cells	cell	NNS
cord-259748-x7dq1sy4	339	25	,	,	,
cord-259748-x7dq1sy4	339	26	and	and	CC
cord-259748-x7dq1sy4	339	27	predisposition	predisposition	NN
cord-259748-x7dq1sy4	339	28	to	to	IN
cord-259748-x7dq1sy4	339	29	cancer	cancer	NN
cord-259748-x7dq1sy4	339	30	(	(	-LRB-
cord-259748-x7dq1sy4	339	31	201	201	CD
cord-259748-x7dq1sy4	339	32	)	)	-RRB-
cord-259748-x7dq1sy4	339	33	.	.	.
cord-259748-x7dq1sy4	340	1	Nevertheless	nevertheless	RB
cord-259748-x7dq1sy4	340	2	,	,	,
cord-259748-x7dq1sy4	340	3	up	up	IN
cord-259748-x7dq1sy4	340	4	-	-	HYPH
cord-259748-x7dq1sy4	340	5	regulation	regulation	NN
cord-259748-x7dq1sy4	340	6	of	of	IN
cord-259748-x7dq1sy4	340	7	expression	expression	NN
cord-259748-x7dq1sy4	340	8	of	of	IN
cord-259748-x7dq1sy4	340	9	type	type	NN
cord-259748-x7dq1sy4	340	10	-	-	:
cord-259748-x7dq1sy4	340	11	I	-PRON-	PRP
cord-259748-x7dq1sy4	340	12	IFN	IFN	NNP
cord-259748-x7dq1sy4	340	13	can	can	MD
cord-259748-x7dq1sy4	340	14	also	also	RB
cord-259748-x7dq1sy4	340	15	be	be	VB
cord-259748-x7dq1sy4	340	16	found	find	VBN
cord-259748-x7dq1sy4	340	17	in	in	IN
cord-259748-x7dq1sy4	340	18	AT	at	IN
cord-259748-x7dq1sy4	340	19	patients	patient	NNS
cord-259748-x7dq1sy4	340	20	and	and	CC
cord-259748-x7dq1sy4	340	21	mice	mouse	NNS
cord-259748-x7dq1sy4	340	22	,	,	,
cord-259748-x7dq1sy4	340	23	causing	cause	VBG
cord-259748-x7dq1sy4	340	24	them	-PRON-	PRP
cord-259748-x7dq1sy4	340	25	to	to	TO
cord-259748-x7dq1sy4	340	26	be	be	VB
cord-259748-x7dq1sy4	340	27	prone	prone	JJ
cord-259748-x7dq1sy4	340	28	to	to	IN
cord-259748-x7dq1sy4	340	29	autoimmune	autoimmune	JJ
cord-259748-x7dq1sy4	340	30	diseases	disease	NNS
cord-259748-x7dq1sy4	340	31	(	(	-LRB-
cord-259748-x7dq1sy4	340	32	36	36	CD
cord-259748-x7dq1sy4	340	33	,	,	,
cord-259748-x7dq1sy4	340	34	183	183	CD
cord-259748-x7dq1sy4	340	35	,	,	,
cord-259748-x7dq1sy4	340	36	202	202	CD
cord-259748-x7dq1sy4	340	37	)	)	-RRB-
cord-259748-x7dq1sy4	340	38	.	.	.
cord-259748-x7dq1sy4	341	1	This	this	DT
cord-259748-x7dq1sy4	341	2	syndrome	syndrome	NN
cord-259748-x7dq1sy4	341	3	is	be	VBZ
cord-259748-x7dq1sy4	341	4	related	relate	VBN
cord-259748-x7dq1sy4	341	5	to	to	IN
cord-259748-x7dq1sy4	341	6	p53-mediated	p53-mediated	JJ
cord-259748-x7dq1sy4	341	7	senescence	senescence	NN
cord-259748-x7dq1sy4	341	8	but	but	CC
cord-259748-x7dq1sy4	341	9	also	also	RB
cord-259748-x7dq1sy4	341	10	the	the	DT
cord-259748-x7dq1sy4	341	11	chronic	chronic	JJ
cord-259748-x7dq1sy4	341	12	inflammation	inflammation	NN
cord-259748-x7dq1sy4	341	13	mediated	mediate	VBN
cord-259748-x7dq1sy4	341	14	by	by	IN
cord-259748-x7dq1sy4	341	15	the	the	DT
cord-259748-x7dq1sy4	341	16	cGAS	cgas	JJ
cord-259748-x7dq1sy4	341	17	-	-	HYPH
cord-259748-x7dq1sy4	341	18	STING	sting	NN
cord-259748-x7dq1sy4	341	19	pathway	pathway	NN
cord-259748-x7dq1sy4	341	20	which	which	WDT
cord-259748-x7dq1sy4	341	21	engages	engage	VBZ
cord-259748-x7dq1sy4	341	22	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	341	23	uncombined	uncombine	VBN
cord-259748-x7dq1sy4	341	24	broken	break	VBN
cord-259748-x7dq1sy4	341	25	gDNA	gdna	RB
cord-259748-x7dq1sy4	341	26	caused	cause	VBN
cord-259748-x7dq1sy4	341	27	by	by	IN
cord-259748-x7dq1sy4	341	28	ATM	atm	NN
cord-259748-x7dq1sy4	341	29	dysfunction	dysfunction	NN
cord-259748-x7dq1sy4	341	30	(	(	-LRB-
cord-259748-x7dq1sy4	341	31	127	127	CD
cord-259748-x7dq1sy4	341	32	)	)	-RRB-
cord-259748-x7dq1sy4	341	33	.	.	.
cord-259748-x7dq1sy4	342	1	In	in	IN
cord-259748-x7dq1sy4	342	2	addition	addition	NN
cord-259748-x7dq1sy4	342	3	,	,	,
cord-259748-x7dq1sy4	342	4	accumulation	accumulation	NN
cord-259748-x7dq1sy4	342	5	of	of	IN
cord-259748-x7dq1sy4	342	6	cellular	cellular	JJ
cord-259748-x7dq1sy4	342	7	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	342	8	occurs	occur	VBZ
cord-259748-x7dq1sy4	342	9	in	in	IN
cord-259748-x7dq1sy4	342	10	age	age	NN
cord-259748-x7dq1sy4	342	11	-	-	HYPH
cord-259748-x7dq1sy4	342	12	related	relate	VBN
cord-259748-x7dq1sy4	342	13	macular	macular	JJ
cord-259748-x7dq1sy4	342	14	degeneration	degeneration	NN
cord-259748-x7dq1sy4	342	15	characterized	characterize	VBN
cord-259748-x7dq1sy4	342	16	by	by	IN
cord-259748-x7dq1sy4	342	17	retinal	retinal	JJ
cord-259748-x7dq1sy4	342	18	pigmented	pigmented	JJ
cord-259748-x7dq1sy4	342	19	epithelium	epithelium	NN
cord-259748-x7dq1sy4	342	20	(	(	-LRB-
cord-259748-x7dq1sy4	342	21	RPE	rpe	NN
cord-259748-x7dq1sy4	342	22	)	)	-RRB-
cord-259748-x7dq1sy4	342	23	degeneration	degeneration	NN
cord-259748-x7dq1sy4	342	24	.	.	.
cord-259748-x7dq1sy4	343	1	This	this	DT
cord-259748-x7dq1sy4	343	2	can	can	MD
cord-259748-x7dq1sy4	343	3	trigger	trigger	VB
cord-259748-x7dq1sy4	343	4	chronic	chronic	JJ
cord-259748-x7dq1sy4	343	5	inflammation	inflammation	NN
cord-259748-x7dq1sy4	343	6	by	by	IN
cord-259748-x7dq1sy4	343	7	cGAS	cga	VBG
cord-259748-x7dq1sy4	343	8	-	-	HYPH
cord-259748-x7dq1sy4	343	9	STING	sting	NN
cord-259748-x7dq1sy4	343	10	pathway	pathway	NN
cord-259748-x7dq1sy4	343	11	,	,	,
cord-259748-x7dq1sy4	343	12	in	in	IN
cord-259748-x7dq1sy4	343	13	which	which	WDT
cord-259748-x7dq1sy4	343	14	NLRP3	nlrp3	NN
cord-259748-x7dq1sy4	344	1	inflammasomes	inflammasome	NNS
cord-259748-x7dq1sy4	344	2	,	,	,
cord-259748-x7dq1sy4	344	3	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	344	4	/	/	SYM
cord-259748-x7dq1sy4	344	5	apoptotic	apoptotic	JJ
cord-259748-x7dq1sy4	344	6	caspases	caspase	NNS
cord-259748-x7dq1sy4	344	7	are	be	VBP
cord-259748-x7dq1sy4	344	8	also	also	RB
cord-259748-x7dq1sy4	344	9	involved	involve	VBN
cord-259748-x7dq1sy4	344	10	(	(	-LRB-
cord-259748-x7dq1sy4	344	11	203	203	CD
cord-259748-x7dq1sy4	344	12	,	,	,
cord-259748-x7dq1sy4	344	13	204	204	CD
cord-259748-x7dq1sy4	344	14	)	)	-RRB-
cord-259748-x7dq1sy4	344	15	.	.	.
cord-259748-x7dq1sy4	345	1	With	with	IN
cord-259748-x7dq1sy4	345	2	regard	regard	NN
cord-259748-x7dq1sy4	345	3	to	to	IN
cord-259748-x7dq1sy4	345	4	other	other	JJ
cord-259748-x7dq1sy4	345	5	diseases	disease	NNS
cord-259748-x7dq1sy4	345	6	in	in	IN
cord-259748-x7dq1sy4	345	7	which	which	WDT
cord-259748-x7dq1sy4	345	8	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	345	9	immune	immune	JJ
cord-259748-x7dq1sy4	345	10	cells	cell	NNS
cord-259748-x7dq1sy4	345	11	prime	prime	JJ
cord-259748-x7dq1sy4	345	12	,	,	,
cord-259748-x7dq1sy4	345	13	cGAS	cgas	JJ
cord-259748-x7dq1sy4	345	14	-	-	:
cord-259748-x7dq1sy4	345	15	STING	sting	NN
cord-259748-x7dq1sy4	345	16	has	have	VBZ
cord-259748-x7dq1sy4	345	17	a	a	DT
cord-259748-x7dq1sy4	345	18	different	different	JJ
cord-259748-x7dq1sy4	345	19	role	role	NN
cord-259748-x7dq1sy4	345	20	.	.	.
cord-259748-x7dq1sy4	346	1	Multiple	multiple	JJ
cord-259748-x7dq1sy4	346	2	sclerosis	sclerosis	NN
cord-259748-x7dq1sy4	346	3	(	(	-LRB-
cord-259748-x7dq1sy4	346	4	MS	MS	NNP
cord-259748-x7dq1sy4	346	5	)	)	-RRB-
cord-259748-x7dq1sy4	346	6	is	be	VBZ
cord-259748-x7dq1sy4	346	7	a	a	DT
cord-259748-x7dq1sy4	346	8	local	local	JJ
cord-259748-x7dq1sy4	346	9	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	346	10	disease	disease	NN
cord-259748-x7dq1sy4	346	11	of	of	IN
cord-259748-x7dq1sy4	346	12	CNS	CNS	NNP
cord-259748-x7dq1sy4	346	13	.	.	.
cord-259748-x7dq1sy4	347	1	MS	MS	NNP
cord-259748-x7dq1sy4	347	2	is	be	VBZ
cord-259748-x7dq1sy4	347	3	characterized	characterize	VBN
cord-259748-x7dq1sy4	347	4	by	by	IN
cord-259748-x7dq1sy4	347	5	over	over	IN
cord-259748-x7dq1sy4	347	6	-	-	HYPH
cord-259748-x7dq1sy4	347	7	reactive	reactive	JJ
cord-259748-x7dq1sy4	347	8	microglia	microglia	NN
cord-259748-x7dq1sy4	347	9	,	,	,
cord-259748-x7dq1sy4	347	10	infiltration	infiltration	NN
cord-259748-x7dq1sy4	347	11	of	of	IN
cord-259748-x7dq1sy4	347	12	self	self	NN
cord-259748-x7dq1sy4	347	13	-	-	HYPH
cord-259748-x7dq1sy4	347	14	reactive	reactive	JJ
cord-259748-x7dq1sy4	347	15	T	t	NN
cord-259748-x7dq1sy4	347	16	cells	cell	NNS
cord-259748-x7dq1sy4	347	17	,	,	,
cord-259748-x7dq1sy4	347	18	demyelization	demyelization	NN
cord-259748-x7dq1sy4	347	19	of	of	IN
cord-259748-x7dq1sy4	347	20	nerve	nerve	NN
cord-259748-x7dq1sy4	347	21	fibers	fiber	NNS
cord-259748-x7dq1sy4	347	22	and	and	CC
cord-259748-x7dq1sy4	347	23	hyperplasia	hyperplasia	NN
cord-259748-x7dq1sy4	347	24	of	of	IN
cord-259748-x7dq1sy4	347	25	gliocytes	gliocyte	NNS
cord-259748-x7dq1sy4	347	26	.	.	.
cord-259748-x7dq1sy4	348	1	Autoantibodies	Autoantibodies	NNP
cord-259748-x7dq1sy4	348	2	against	against	IN
cord-259748-x7dq1sy4	348	3	proteins	protein	NNS
cord-259748-x7dq1sy4	348	4	expressed	express	VBN
cord-259748-x7dq1sy4	348	5	in	in	IN
cord-259748-x7dq1sy4	348	6	immune	immune	JJ
cord-259748-x7dq1sy4	348	7	-	-	HYPH
cord-259748-x7dq1sy4	348	8	privileged	privileged	JJ
cord-259748-x7dq1sy4	348	9	regions	region	NNS
cord-259748-x7dq1sy4	348	10	of	of	IN
cord-259748-x7dq1sy4	348	11	CNS	CNS	NNP
cord-259748-x7dq1sy4	348	12	also	also	RB
cord-259748-x7dq1sy4	348	13	contribute	contribute	VBP
cord-259748-x7dq1sy4	348	14	to	to	IN
cord-259748-x7dq1sy4	348	15	its	-PRON-	PRP$
cord-259748-x7dq1sy4	348	16	pathogenesis	pathogenesis	NN
cord-259748-x7dq1sy4	348	17	(	(	-LRB-
cord-259748-x7dq1sy4	348	18	205	205	CD
cord-259748-x7dq1sy4	348	19	)	)	-RRB-
cord-259748-x7dq1sy4	348	20	.	.	.
cord-259748-x7dq1sy4	349	1	In	in	IN
cord-259748-x7dq1sy4	349	2	MS	MS	NNP
cord-259748-x7dq1sy4	349	3	,	,	,
cord-259748-x7dq1sy4	349	4	IFNα	IFNα	NNP
cord-259748-x7dq1sy4	349	5	/	/	SYM
cord-259748-x7dq1sy4	349	6	β	β	NN
cord-259748-x7dq1sy4	349	7	can	can	MD
cord-259748-x7dq1sy4	349	8	attenuate	attenuate	VB
cord-259748-x7dq1sy4	349	9	disease	disease	NN
cord-259748-x7dq1sy4	349	10	severity	severity	NN
cord-259748-x7dq1sy4	349	11	effectively	effectively	RB
cord-259748-x7dq1sy4	349	12	.	.	.
cord-259748-x7dq1sy4	350	1	This	this	DT
cord-259748-x7dq1sy4	350	2	implies	imply	VBZ
cord-259748-x7dq1sy4	350	3	a	a	DT
cord-259748-x7dq1sy4	350	4	protective	protective	JJ
cord-259748-x7dq1sy4	350	5	role	role	NN
cord-259748-x7dq1sy4	350	6	for	for	IN
cord-259748-x7dq1sy4	350	7	type	type	NN
cord-259748-x7dq1sy4	350	8	-	-	:
cord-259748-x7dq1sy4	350	9	I	-PRON-	PRP
cord-259748-x7dq1sy4	350	10	IFN	IFN	NNP
cord-259748-x7dq1sy4	350	11	in	in	IN
cord-259748-x7dq1sy4	350	12	CNS	CNS	NNP
cord-259748-x7dq1sy4	350	13	,	,	,
cord-259748-x7dq1sy4	350	14	which	which	WDT
cord-259748-x7dq1sy4	350	15	is	be	VBZ
cord-259748-x7dq1sy4	350	16	considered	consider	VBN
cord-259748-x7dq1sy4	350	17	to	to	TO
cord-259748-x7dq1sy4	350	18	counteract	counteract	VB
cord-259748-x7dq1sy4	350	19	the	the	DT
cord-259748-x7dq1sy4	350	20	pro	pro	JJ
cord-259748-x7dq1sy4	350	21	-	-	JJ
cord-259748-x7dq1sy4	350	22	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	350	23	IFNγ	IFNγ	NNS
cord-259748-x7dq1sy4	350	24	(	(	-LRB-
cord-259748-x7dq1sy4	350	25	206	206	CD
cord-259748-x7dq1sy4	350	26	)	)	-RRB-
cord-259748-x7dq1sy4	350	27	.	.	.
cord-259748-x7dq1sy4	351	1	Using	use	VBG
cord-259748-x7dq1sy4	351	2	experimental	experimental	JJ
cord-259748-x7dq1sy4	351	3	autoimmune	autoimmune	NN
cord-259748-x7dq1sy4	351	4	encephalitis	encephalitis	RB
cord-259748-x7dq1sy4	351	5	(	(	-LRB-
cord-259748-x7dq1sy4	351	6	EAE	EAE	NNP
cord-259748-x7dq1sy4	351	7	)	)	-RRB-
cord-259748-x7dq1sy4	351	8	as	as	IN
cord-259748-x7dq1sy4	351	9	a	a	DT
cord-259748-x7dq1sy4	351	10	MS	MS	NNP
cord-259748-x7dq1sy4	351	11	model	model	NN
cord-259748-x7dq1sy4	351	12	,	,	,
cord-259748-x7dq1sy4	351	13	STING	STING	NNP
cord-259748-x7dq1sy4	351	14	was	be	VBD
cord-259748-x7dq1sy4	351	15	found	find	VBN
cord-259748-x7dq1sy4	351	16	to	to	TO
cord-259748-x7dq1sy4	351	17	be	be	VB
cord-259748-x7dq1sy4	351	18	indispensable	indispensable	JJ
cord-259748-x7dq1sy4	351	19	for	for	IN
cord-259748-x7dq1sy4	351	20	amelioration	amelioration	NN
cord-259748-x7dq1sy4	351	21	of	of	IN
cord-259748-x7dq1sy4	351	22	type	type	NN
cord-259748-x7dq1sy4	351	23	-	-	:
cord-259748-x7dq1sy4	351	24	I	-PRON-	PRP
cord-259748-x7dq1sy4	351	25	IFNmediated	ifnmediate	VBN
cord-259748-x7dq1sy4	351	26	neuroinflammation	neuroinflammation	NN
cord-259748-x7dq1sy4	351	27	,	,	,
cord-259748-x7dq1sy4	351	28	and	and	CC
cord-259748-x7dq1sy4	351	29	it	-PRON-	PRP
cord-259748-x7dq1sy4	351	30	could	could	MD
cord-259748-x7dq1sy4	351	31	be	be	VB
cord-259748-x7dq1sy4	351	32	induced	induce	VBN
cord-259748-x7dq1sy4	351	33	by	by	IN
cord-259748-x7dq1sy4	351	34	a	a	DT
cord-259748-x7dq1sy4	351	35	conventional	conventional	JJ
cord-259748-x7dq1sy4	351	36	anti	anti	JJ
cord-259748-x7dq1sy4	351	37	-	-	JJ
cord-259748-x7dq1sy4	351	38	viral	viral	JJ
cord-259748-x7dq1sy4	351	39	drug	drug	NN
cord-259748-x7dq1sy4	351	40	ganciclovir	ganciclovir	NNS
cord-259748-x7dq1sy4	351	41	(	(	-LRB-
cord-259748-x7dq1sy4	351	42	207	207	CD
cord-259748-x7dq1sy4	351	43	)	)	-RRB-
cord-259748-x7dq1sy4	351	44	.	.	.
cord-259748-x7dq1sy4	352	1	Ultraviolet	ultraviolet	NN
cord-259748-x7dq1sy4	352	2	(	(	-LRB-
cord-259748-x7dq1sy4	352	3	UV	uv	NN
cord-259748-x7dq1sy4	352	4	)	)	-RRB-
cord-259748-x7dq1sy4	352	5	radiation	radiation	NN
cord-259748-x7dq1sy4	352	6	is	be	VBZ
cord-259748-x7dq1sy4	352	7	a	a	DT
cord-259748-x7dq1sy4	352	8	factor	factor	NN
cord-259748-x7dq1sy4	352	9	inversely	inversely	RB
cord-259748-x7dq1sy4	352	10	related	relate	VBN
cord-259748-x7dq1sy4	352	11	to	to	IN
cord-259748-x7dq1sy4	352	12	the	the	DT
cord-259748-x7dq1sy4	352	13	morbidity	morbidity	NN
cord-259748-x7dq1sy4	352	14	of	of	IN
cord-259748-x7dq1sy4	352	15	MS	MS	NNP
cord-259748-x7dq1sy4	352	16	(	(	-LRB-
cord-259748-x7dq1sy4	352	17	208	208	CD
cord-259748-x7dq1sy4	352	18	)	)	-RRB-
cord-259748-x7dq1sy4	352	19	.	.	.
cord-259748-x7dq1sy4	353	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	353	2	was	be	VBD
cord-259748-x7dq1sy4	353	3	found	find	VBN
cord-259748-x7dq1sy4	353	4	that	that	IN
cord-259748-x7dq1sy4	353	5	UV	uv	NN
cord-259748-x7dq1sy4	353	6	-	-	HYPH
cord-259748-x7dq1sy4	353	7	B	b	NN
cord-259748-x7dq1sy4	353	8	irradiation	irradiation	NN
cord-259748-x7dq1sy4	353	9	can	can	MD
cord-259748-x7dq1sy4	353	10	recruit	recruit	VB
cord-259748-x7dq1sy4	353	11	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	353	12	monocytes	monocyte	NNS
cord-259748-x7dq1sy4	353	13	and	and	CC
cord-259748-x7dq1sy4	353	14	produce	produce	NN
cord-259748-x7dq1sy4	353	15	type	type	NN
cord-259748-x7dq1sy4	354	1	-I	-I	NFP
cord-259748-x7dq1sy4	354	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	354	3	in	in	IN
cord-259748-x7dq1sy4	354	4	a	a	DT
cord-259748-x7dq1sy4	354	5	STING	sting	NN
cord-259748-x7dq1sy4	354	6	-	-	HYPH
cord-259748-x7dq1sy4	354	7	dependent	dependent	JJ
cord-259748-x7dq1sy4	354	8	manner	manner	NN
cord-259748-x7dq1sy4	354	9	(	(	-LRB-
cord-259748-x7dq1sy4	354	10	209	209	CD
cord-259748-x7dq1sy4	354	11	)	)	-RRB-
cord-259748-x7dq1sy4	354	12	.	.	.
cord-259748-x7dq1sy4	355	1	All	all	DT
cord-259748-x7dq1sy4	355	2	above	above	RB
cord-259748-x7dq1sy4	355	3	indicate	indicate	VBP
cord-259748-x7dq1sy4	355	4	that	that	IN
cord-259748-x7dq1sy4	355	5	cGAS	cgas	JJ
cord-259748-x7dq1sy4	355	6	-	-	HYPH
cord-259748-x7dq1sy4	355	7	STING	sting	NN
cord-259748-x7dq1sy4	355	8	-	-	HYPH
cord-259748-x7dq1sy4	355	9	IFNα	IFNα	NNP
cord-259748-x7dq1sy4	355	10	/	/	SYM
cord-259748-x7dq1sy4	355	11	β	β	NNP
cord-259748-x7dq1sy4	355	12	pathway	pathway	NN
cord-259748-x7dq1sy4	355	13	may	may	MD
cord-259748-x7dq1sy4	355	14	have	have	VB
cord-259748-x7dq1sy4	355	15	a	a	DT
cord-259748-x7dq1sy4	355	16	beneficial	beneficial	JJ
cord-259748-x7dq1sy4	355	17	effect	effect	NN
cord-259748-x7dq1sy4	355	18	on	on	IN
cord-259748-x7dq1sy4	355	19	some	some	DT
cord-259748-x7dq1sy4	355	20	CNS	cns	JJ
cord-259748-x7dq1sy4	355	21	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	355	22	diseases	disease	NNS
cord-259748-x7dq1sy4	355	23	such	such	JJ
cord-259748-x7dq1sy4	355	24	as	as	IN
cord-259748-x7dq1sy4	355	25	MS	MS	NNP
cord-259748-x7dq1sy4	355	26	.	.	.
cord-259748-x7dq1sy4	356	1	A	a	DT
cord-259748-x7dq1sy4	356	2	possible	possible	JJ
cord-259748-x7dq1sy4	356	3	reason	reason	NN
cord-259748-x7dq1sy4	356	4	for	for	IN
cord-259748-x7dq1sy4	356	5	the	the	DT
cord-259748-x7dq1sy4	356	6	observed	observed	JJ
cord-259748-x7dq1sy4	356	7	effect	effect	NN
cord-259748-x7dq1sy4	356	8	above	above	RB
cord-259748-x7dq1sy4	356	9	is	be	VBZ
cord-259748-x7dq1sy4	356	10	due	due	JJ
cord-259748-x7dq1sy4	356	11	to	to	TO
cord-259748-x7dq1sy4	356	12	indoleamine	indoleamine	VB
cord-259748-x7dq1sy4	356	13	2,3-dioxygenase	2,3-dioxygenase	NNP
cord-259748-x7dq1sy4	356	14	(	(	-LRB-
cord-259748-x7dq1sy4	356	15	IDO	IDO	NNP
cord-259748-x7dq1sy4	356	16	)	)	-RRB-
cord-259748-x7dq1sy4	356	17	,	,	,
cord-259748-x7dq1sy4	356	18	which	which	WDT
cord-259748-x7dq1sy4	356	19	can	can	MD
cord-259748-x7dq1sy4	356	20	catabolize	catabolize	VB
cord-259748-x7dq1sy4	356	21	tryptophan	tryptophan	NN
cord-259748-x7dq1sy4	356	22	(	(	-LRB-
cord-259748-x7dq1sy4	356	23	Trp	trp	NN
cord-259748-x7dq1sy4	356	24	)	)	-RRB-
cord-259748-x7dq1sy4	357	1	oxidatively	oxidatively	RB
cord-259748-x7dq1sy4	357	2	.	.	.
cord-259748-x7dq1sy4	358	1	Trp	Trp	NNP
cord-259748-x7dq1sy4	358	2	withdrawal	withdrawal	NN
cord-259748-x7dq1sy4	358	3	or	or	CC
cord-259748-x7dq1sy4	358	4	Trpoxidative	Trpoxidative	NNP
cord-259748-x7dq1sy4	358	5	catabolites	catabolite	NNS
cord-259748-x7dq1sy4	358	6	can	can	MD
cord-259748-x7dq1sy4	358	7	interact	interact	VB
cord-259748-x7dq1sy4	358	8	with	with	IN
cord-259748-x7dq1sy4	358	9	general	general	JJ
cord-259748-x7dq1sy4	358	10	control	control	NN
cord-259748-x7dq1sy4	358	11	non	non	JJ
cord-259748-x7dq1sy4	358	12	-	-	JJ
cord-259748-x7dq1sy4	358	13	derepressible	derepressible	JJ
cord-259748-x7dq1sy4	358	14	2	2	CD
cord-259748-x7dq1sy4	358	15	(	(	-LRB-
cord-259748-x7dq1sy4	358	16	GCN2	GCN2	NNP
cord-259748-x7dq1sy4	358	17	)	)	-RRB-
cord-259748-x7dq1sy4	358	18	and	and	CC
cord-259748-x7dq1sy4	358	19	mTOR	mTOR	NNP
cord-259748-x7dq1sy4	358	20	,	,	,
cord-259748-x7dq1sy4	358	21	of	of	IN
cord-259748-x7dq1sy4	358	22	which	which	WDT
cord-259748-x7dq1sy4	358	23	both	both	DT
cord-259748-x7dq1sy4	358	24	can	can	MD
cord-259748-x7dq1sy4	358	25	control	control	VB
cord-259748-x7dq1sy4	358	26	cellular	cellular	JJ
cord-259748-x7dq1sy4	358	27	aminoacid	aminoacid	JJ
cord-259748-x7dq1sy4	358	28	metabolism	metabolism	NN
cord-259748-x7dq1sy4	358	29	and	and	CC
cord-259748-x7dq1sy4	358	30	suppress	suppress	VB
cord-259748-x7dq1sy4	358	31	T	T	NNP
cord-259748-x7dq1sy4	358	32	helper	helper	NN
cord-259748-x7dq1sy4	358	33	1	1	CD
cord-259748-x7dq1sy4	359	1	(	(	-LRB-
cord-259748-x7dq1sy4	359	2	T	T	NNP
cord-259748-x7dq1sy4	359	3	h	h	NN
cord-259748-x7dq1sy4	359	4	1	1	CD
cord-259748-x7dq1sy4	359	5	)	)	-RRB-
cord-259748-x7dq1sy4	359	6	cells	cell	NNS
cord-259748-x7dq1sy4	359	7	immunity	immunity	NN
cord-259748-x7dq1sy4	359	8	(	(	-LRB-
cord-259748-x7dq1sy4	359	9	210	210	CD
cord-259748-x7dq1sy4	359	10	)	)	-RRB-
cord-259748-x7dq1sy4	359	11	.	.	.
cord-259748-x7dq1sy4	360	1	IFNα	IFNα	NNP
cord-259748-x7dq1sy4	360	2	/	/	SYM
cord-259748-x7dq1sy4	360	3	β	β	NNP
cord-259748-x7dq1sy4	360	4	is	be	VBZ
cord-259748-x7dq1sy4	360	5	a	a	DT
cord-259748-x7dq1sy4	360	6	potent	potent	JJ
cord-259748-x7dq1sy4	360	7	IDO	IDO	NNP
cord-259748-x7dq1sy4	360	8	inducer	inducer	NN
cord-259748-x7dq1sy4	360	9	to	to	TO
cord-259748-x7dq1sy4	360	10	suppress	suppress	VB
cord-259748-x7dq1sy4	360	11	proliferation	proliferation	NN
cord-259748-x7dq1sy4	360	12	of	of	IN
cord-259748-x7dq1sy4	360	13	CD4	CD4	NNP
cord-259748-x7dq1sy4	360	14	+	+	CC
cord-259748-x7dq1sy4	360	15	T	T	NNP
cord-259748-x7dq1sy4	360	16	h	h	NN
cord-259748-x7dq1sy4	360	17	1	1	CD
cord-259748-x7dq1sy4	360	18	cells	cell	NNS
cord-259748-x7dq1sy4	360	19	and	and	CC
cord-259748-x7dq1sy4	360	20	promote	promote	VB
cord-259748-x7dq1sy4	360	21	differentiation	differentiation	NN
cord-259748-x7dq1sy4	360	22	of	of	IN
cord-259748-x7dq1sy4	360	23	Foxp3	foxp3	JJ
cord-259748-x7dq1sy4	360	24	+	+	CC
cord-259748-x7dq1sy4	360	25	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	360	26	T	T	NNP
cord-259748-x7dq1sy4	360	27	(	(	-LRB-
cord-259748-x7dq1sy4	360	28	T	T	NNP
cord-259748-x7dq1sy4	360	29	reg	reg	NNP
cord-259748-x7dq1sy4	360	30	)	)	-RRB-
cord-259748-x7dq1sy4	360	31	cells	cell	NNS
cord-259748-x7dq1sy4	360	32	,	,	,
cord-259748-x7dq1sy4	360	33	which	which	WDT
cord-259748-x7dq1sy4	360	34	are	be	VBP
cord-259748-x7dq1sy4	360	35	believed	believe	VBN
cord-259748-x7dq1sy4	360	36	to	to	TO
cord-259748-x7dq1sy4	360	37	suppress	suppress	VB
cord-259748-x7dq1sy4	360	38	CNSspecific	cnsspecific	NN
cord-259748-x7dq1sy4	360	39	autoimmunity	autoimmunity	NN
cord-259748-x7dq1sy4	360	40	(	(	-LRB-
cord-259748-x7dq1sy4	360	41	210	210	CD
cord-259748-x7dq1sy4	360	42	,	,	,
cord-259748-x7dq1sy4	360	43	211	211	CD
cord-259748-x7dq1sy4	360	44	)	)	-RRB-
cord-259748-x7dq1sy4	360	45	.	.	.
cord-259748-x7dq1sy4	361	1	In	in	IN
cord-259748-x7dq1sy4	361	2	addition	addition	NN
cord-259748-x7dq1sy4	361	3	,	,	,
cord-259748-x7dq1sy4	361	4	DNA	DNA	NNP
cord-259748-x7dq1sy4	361	5	released	release	VBN
cord-259748-x7dq1sy4	361	6	from	from	IN
cord-259748-x7dq1sy4	361	7	dying	die	VBG
cord-259748-x7dq1sy4	361	8	cells	cell	NNS
cord-259748-x7dq1sy4	361	9	can	can	MD
cord-259748-x7dq1sy4	361	10	be	be	VB
cord-259748-x7dq1sy4	361	11	internalized	internalize	VBN
cord-259748-x7dq1sy4	361	12	directly	directly	RB
cord-259748-x7dq1sy4	361	13	by	by	IN
cord-259748-x7dq1sy4	361	14	T	T	NNP
cord-259748-x7dq1sy4	361	15	cells	cell	NNS
cord-259748-x7dq1sy4	361	16	and	and	CC
cord-259748-x7dq1sy4	361	17	sensed	sense	VBN
cord-259748-x7dq1sy4	361	18	by	by	IN
cord-259748-x7dq1sy4	361	19	cGAS	cgas	JJ
cord-259748-x7dq1sy4	361	20	-	-	HYPH
cord-259748-x7dq1sy4	361	21	STING	sting	NN
cord-259748-x7dq1sy4	361	22	pathway	pathway	NN
cord-259748-x7dq1sy4	361	23	,	,	,
cord-259748-x7dq1sy4	361	24	which	which	WDT
cord-259748-x7dq1sy4	361	25	leads	lead	VBZ
cord-259748-x7dq1sy4	361	26	to	to	IN
cord-259748-x7dq1sy4	361	27	enhancement	enhancement	NN
cord-259748-x7dq1sy4	361	28	of	of	IN
cord-259748-x7dq1sy4	361	29	the	the	DT
cord-259748-x7dq1sy4	361	30	T	t	NN
cord-259748-x7dq1sy4	361	31	h	h	NN
cord-259748-x7dq1sy4	361	32	2	2	CD
cord-259748-x7dq1sy4	361	33	transcription	transcription	NN
cord-259748-x7dq1sy4	361	34	factor	factor	NN
cord-259748-x7dq1sy4	361	35	GATA3	GATA3	NNP
cord-259748-x7dq1sy4	362	1	but	but	CC
cord-259748-x7dq1sy4	362	2	suppression	suppression	NN
cord-259748-x7dq1sy4	362	3	of	of	IN
cord-259748-x7dq1sy4	362	4	the	the	DT
cord-259748-x7dq1sy4	362	5	T	T	NNP
cord-259748-x7dq1sy4	362	6	h	h	NN
cord-259748-x7dq1sy4	362	7	1	1	CD
cord-259748-x7dq1sy4	362	8	transcription	transcription	NN
cord-259748-x7dq1sy4	362	9	factor	factor	NN
cord-259748-x7dq1sy4	362	10	T	t	NN
cord-259748-x7dq1sy4	362	11	-	-	HYPH
cord-259748-x7dq1sy4	362	12	bet	bet	NN
cord-259748-x7dq1sy4	362	13	.	.	.
cord-259748-x7dq1sy4	363	1	Consequently	consequently	RB
cord-259748-x7dq1sy4	363	2	,	,	,
cord-259748-x7dq1sy4	363	3	this	this	DT
cord-259748-x7dq1sy4	363	4	process	process	NN
cord-259748-x7dq1sy4	363	5	polarizes	polarize	VBZ
cord-259748-x7dq1sy4	363	6	naive	naive	JJ
cord-259748-x7dq1sy4	363	7	T	t	NN
cord-259748-x7dq1sy4	363	8	cells	cell	NNS
cord-259748-x7dq1sy4	363	9	toward	toward	IN
cord-259748-x7dq1sy4	363	10	T	T	NNP
cord-259748-x7dq1sy4	363	11	h	h	NN
cord-259748-x7dq1sy4	363	12	2	2	CD
cord-259748-x7dq1sy4	363	13	differentiation	differentiation	NN
cord-259748-x7dq1sy4	363	14	(	(	-LRB-
cord-259748-x7dq1sy4	363	15	212	212	CD
cord-259748-x7dq1sy4	363	16	)	)	-RRB-
cord-259748-x7dq1sy4	363	17	.	.	.
cord-259748-x7dq1sy4	364	1	Studies	study	NNS
cord-259748-x7dq1sy4	364	2	mentioned	mention	VBN
cord-259748-x7dq1sy4	364	3	above	above	RB
cord-259748-x7dq1sy4	364	4	may	may	NNP
cord-259748-x7dq1sy4	364	5	(	(	-LRB-
cord-259748-x7dq1sy4	364	6	at	at	IN
cord-259748-x7dq1sy4	364	7	least	least	JJS
cord-259748-x7dq1sy4	364	8	in	in	IN
cord-259748-x7dq1sy4	364	9	part	part	NN
cord-259748-x7dq1sy4	364	10	)	)	-RRB-
cord-259748-x7dq1sy4	364	11	explain	explain	VB
cord-259748-x7dq1sy4	364	12	why	why	WRB
cord-259748-x7dq1sy4	364	13	the	the	DT
cord-259748-x7dq1sy4	364	14	cGAS	cgas	JJ
cord-259748-x7dq1sy4	364	15	-	-	HYPH
cord-259748-x7dq1sy4	364	16	STING	sting	NN
cord-259748-x7dq1sy4	364	17	signal	signal	NN
cord-259748-x7dq1sy4	364	18	is	be	VBZ
cord-259748-x7dq1sy4	364	19	a	a	DT
cord-259748-x7dq1sy4	364	20	negative	negative	JJ
cord-259748-x7dq1sy4	364	21	regulator	regulator	NN
cord-259748-x7dq1sy4	364	22	of	of	IN
cord-259748-x7dq1sy4	364	23	MS	MS	NNP
cord-259748-x7dq1sy4	364	24	.	.	.
cord-259748-x7dq1sy4	365	1	The	the	DT
cord-259748-x7dq1sy4	365	2	inhibitory	inhibitory	JJ
cord-259748-x7dq1sy4	365	3	role	role	NN
cord-259748-x7dq1sy4	365	4	of	of	IN
cord-259748-x7dq1sy4	365	5	cGAS	cgas	NN
cord-259748-x7dq1sy4	365	6	-	-	HYPH
cord-259748-x7dq1sy4	365	7	STING	sting	NN
cord-259748-x7dq1sy4	365	8	in	in	IN
cord-259748-x7dq1sy4	365	9	inflammation	inflammation	NN
cord-259748-x7dq1sy4	365	10	is	be	VBZ
cord-259748-x7dq1sy4	365	11	also	also	RB
cord-259748-x7dq1sy4	365	12	attributed	attribute	VBN
cord-259748-x7dq1sy4	365	13	to	to	IN
cord-259748-x7dq1sy4	365	14	its	-PRON-	PRP$
cord-259748-x7dq1sy4	365	15	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	365	16	-	-	HYPH
cord-259748-x7dq1sy4	365	17	triggering	trigger	VBG
cord-259748-x7dq1sy4	365	18	role	role	NN
cord-259748-x7dq1sy4	365	19	.	.	.
cord-259748-x7dq1sy4	366	1	In	in	IN
cord-259748-x7dq1sy4	366	2	some	some	DT
cord-259748-x7dq1sy4	366	3	subtypes	subtype	NNS
cord-259748-x7dq1sy4	366	4	of	of	IN
cord-259748-x7dq1sy4	366	5	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	366	6	and	and	CC
cord-259748-x7dq1sy4	366	7	mouse	mouse	NN
cord-259748-x7dq1sy4	366	8	models	model	NNS
cord-259748-x7dq1sy4	366	9	,	,	,
cord-259748-x7dq1sy4	366	10	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	366	11	of	of	IN
cord-259748-x7dq1sy4	366	12	blood	blood	NN
cord-259748-x7dq1sy4	366	13	-	-	HYPH
cord-259748-x7dq1sy4	366	14	vessel	vessel	NN
cord-259748-x7dq1sy4	366	15	endothelial	endothelial	JJ
cord-259748-x7dq1sy4	366	16	cells	cell	NNS
cord-259748-x7dq1sy4	366	17	or	or	CC
cord-259748-x7dq1sy4	366	18	bronchial	bronchial	JJ
cord-259748-x7dq1sy4	366	19	epithelial	epithelial	JJ
cord-259748-x7dq1sy4	366	20	cells	cell	NNS
cord-259748-x7dq1sy4	366	21	and	and	CC
cord-259748-x7dq1sy4	366	22	leucopenia	leucopenia	NNP
cord-259748-x7dq1sy4	366	23	can	can	MD
cord-259748-x7dq1sy4	366	24	be	be	VB
cord-259748-x7dq1sy4	366	25	observed	observe	VBN
cord-259748-x7dq1sy4	366	26	(	(	-LRB-
cord-259748-x7dq1sy4	366	27	especially	especially	RB
cord-259748-x7dq1sy4	366	28	T	t	NN
cord-259748-x7dq1sy4	366	29	-	-	HYPH
cord-259748-x7dq1sy4	366	30	cell	cell	NN
cord-259748-x7dq1sy4	366	31	lymphopenia	lymphopenia	NNP
cord-259748-x7dq1sy4	366	32	)	)	-RRB-
cord-259748-x7dq1sy4	366	33	(	(	-LRB-
cord-259748-x7dq1sy4	366	34	166	166	CD
cord-259748-x7dq1sy4	366	35	,	,	,
cord-259748-x7dq1sy4	366	36	169	169	CD
cord-259748-x7dq1sy4	366	37	,	,	,
cord-259748-x7dq1sy4	366	38	170	170	CD
cord-259748-x7dq1sy4	366	39	)	)	-RRB-
cord-259748-x7dq1sy4	366	40	.	.	.
cord-259748-x7dq1sy4	367	1	When	when	WRB
cord-259748-x7dq1sy4	367	2	the	the	DT
cord-259748-x7dq1sy4	367	3	STING	sting	NN
cord-259748-x7dq1sy4	367	4	signal	signal	NN
cord-259748-x7dq1sy4	367	5	is	be	VBZ
cord-259748-x7dq1sy4	367	6	stimulated	stimulate	VBN
cord-259748-x7dq1sy4	367	7	,	,	,
cord-259748-x7dq1sy4	367	8	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	367	9	occurs	occur	VBZ
cord-259748-x7dq1sy4	367	10	more	more	RBR
cord-259748-x7dq1sy4	367	11	frequently	frequently	RB
cord-259748-x7dq1sy4	367	12	in	in	IN
cord-259748-x7dq1sy4	367	13	normal	normal	JJ
cord-259748-x7dq1sy4	367	14	or	or	CC
cord-259748-x7dq1sy4	367	15	cancerous	cancerous	JJ
cord-259748-x7dq1sy4	367	16	T	t	NN
cord-259748-x7dq1sy4	367	17	cells	cell	NNS
cord-259748-x7dq1sy4	367	18	(	(	-LRB-
cord-259748-x7dq1sy4	367	19	119	119	CD
cord-259748-x7dq1sy4	367	20	)	)	-RRB-
cord-259748-x7dq1sy4	367	21	.	.	.
cord-259748-x7dq1sy4	368	1	Also	also	RB
cord-259748-x7dq1sy4	368	2	,	,	,
cord-259748-x7dq1sy4	368	3	bone	bone	NN
cord-259748-x7dq1sy4	368	4	-	-	HYPH
cord-259748-x7dq1sy4	368	5	marrow	marrow	NN
cord-259748-x7dq1sy4	368	6	chimeras	chimera	NNS
cord-259748-x7dq1sy4	368	7	and	and	CC
cord-259748-x7dq1sy4	368	8	gene	gene	NN
cord-259748-x7dq1sy4	368	9	-	-	HYPH
cord-259748-x7dq1sy4	368	10	knockout	knockout	NN
cord-259748-x7dq1sy4	368	11	studies	study	NNS
cord-259748-x7dq1sy4	368	12	have	have	VBP
cord-259748-x7dq1sy4	368	13	shown	show	VBN
cord-259748-x7dq1sy4	368	14	that	that	IN
cord-259748-x7dq1sy4	368	15	T	T	NNP
cord-259748-x7dq1sy4	368	16	cells	cell	NNS
cord-259748-x7dq1sy4	368	17	defect	defect	VBP
cord-259748-x7dq1sy4	368	18	in	in	IN
cord-259748-x7dq1sy4	368	19	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	368	20	are	be	VBP
cord-259748-x7dq1sy4	368	21	not	not	RB
cord-259748-x7dq1sy4	368	22	associated	associate	VBN
cord-259748-x7dq1sy4	368	23	with	with	IN
cord-259748-x7dq1sy4	368	24	type	type	NN
cord-259748-x7dq1sy4	368	25	-	-	:
cord-259748-x7dq1sy4	368	26	I	-PRON-	PRP
cord-259748-x7dq1sy4	368	27	IFN	IFN	NNP
cord-259748-x7dq1sy4	368	28	signaling	signal	VBG
cord-259748-x7dq1sy4	368	29	or	or	CC
cord-259748-x7dq1sy4	368	30	cGAS	cgas	JJ
cord-259748-x7dq1sy4	368	31	(	(	-LRB-
cord-259748-x7dq1sy4	368	32	213	213	CD
cord-259748-x7dq1sy4	368	33	,	,	,
cord-259748-x7dq1sy4	368	34	214	214	CD
cord-259748-x7dq1sy4	368	35	)	)	-RRB-
cord-259748-x7dq1sy4	368	36	.	.	.
cord-259748-x7dq1sy4	369	1	Localization	localization	NN
cord-259748-x7dq1sy4	369	2	of	of	IN
cord-259748-x7dq1sy4	369	3	STING	sting	NN
cord-259748-x7dq1sy4	369	4	at	at	IN
cord-259748-x7dq1sy4	369	5	the	the	DT
cord-259748-x7dq1sy4	369	6	Golgi	Golgi	NNP
cord-259748-x7dq1sy4	369	7	can	can	MD
cord-259748-x7dq1sy4	369	8	cause	cause	VB
cord-259748-x7dq1sy4	369	9	delay	delay	NN
cord-259748-x7dq1sy4	369	10	of	of	IN
cord-259748-x7dq1sy4	369	11	T	t	NN
cord-259748-x7dq1sy4	369	12	-	-	HYPH
cord-259748-x7dq1sy4	369	13	cell	cell	NN
cord-259748-x7dq1sy4	369	14	mitosis	mitosis	NN
cord-259748-x7dq1sy4	369	15	and	and	CC
cord-259748-x7dq1sy4	369	16	reduced	reduce	VBN
cord-259748-x7dq1sy4	369	17	proliferation	proliferation	NN
cord-259748-x7dq1sy4	369	18	independently	independently	RB
cord-259748-x7dq1sy4	369	19	of	of	IN
cord-259748-x7dq1sy4	369	20	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	369	21	and	and	CC
cord-259748-x7dq1sy4	369	22	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	369	23	(	(	-LRB-
cord-259748-x7dq1sy4	369	24	215	215	CD
cord-259748-x7dq1sy4	369	25	)	)	-RRB-
cord-259748-x7dq1sy4	369	26	.	.	.
cord-259748-x7dq1sy4	370	1	Furthermore	furthermore	RB
cord-259748-x7dq1sy4	370	2	,	,	,
cord-259748-x7dq1sy4	370	3	a	a	DT
cord-259748-x7dq1sy4	370	4	"	"	``
cord-259748-x7dq1sy4	370	5	UPR	UPR	NNP
cord-259748-x7dq1sy4	370	6	motif	motif	NN
cord-259748-x7dq1sy4	370	7	"	"	''
cord-259748-x7dq1sy4	370	8	on	on	IN
cord-259748-x7dq1sy4	370	9	the	the	DT
cord-259748-x7dq1sy4	370	10	C	c	NN
cord-259748-x7dq1sy4	370	11	-	-	HYPH
cord-259748-x7dq1sy4	370	12	terminus	terminus	NN
cord-259748-x7dq1sy4	370	13	of	of	IN
cord-259748-x7dq1sy4	370	14	STING	sting	NN
cord-259748-x7dq1sy4	370	15	can	can	MD
cord-259748-x7dq1sy4	370	16	cause	cause	VB
cord-259748-x7dq1sy4	370	17	ER	ER	NNP
cord-259748-x7dq1sy4	370	18	stress	stress	NN
cord-259748-x7dq1sy4	370	19	and	and	CC
cord-259748-x7dq1sy4	370	20	UPR	UPR	NNP
cord-259748-x7dq1sy4	370	21	,	,	,
cord-259748-x7dq1sy4	370	22	resulting	result	VBG
cord-259748-x7dq1sy4	370	23	in	in	IN
cord-259748-x7dq1sy4	370	24	Ca	Ca	NNP
cord-259748-x7dq1sy4	370	25	2	2	CD
cord-259748-x7dq1sy4	370	26	+	+	SYM
cord-259748-x7dq1sy4	370	27	overloading	overloading	NN
cord-259748-x7dq1sy4	370	28	and	and	CC
cord-259748-x7dq1sy4	370	29	T	t	NN
cord-259748-x7dq1sy4	370	30	-	-	HYPH
cord-259748-x7dq1sy4	370	31	cell	cell	NN
cord-259748-x7dq1sy4	370	32	death	death	NN
cord-259748-x7dq1sy4	370	33	(	(	-LRB-
cord-259748-x7dq1sy4	370	34	82	82	CD
cord-259748-x7dq1sy4	370	35	)	)	-RRB-
cord-259748-x7dq1sy4	370	36	.	.	.
cord-259748-x7dq1sy4	371	1	A	a	DT
cord-259748-x7dq1sy4	371	2	controversial	controversial	JJ
cord-259748-x7dq1sy4	371	3	view	view	NN
cord-259748-x7dq1sy4	371	4	is	be	VBZ
cord-259748-x7dq1sy4	371	5	that	that	DT
cord-259748-x7dq1sy4	371	6	B	b	NN
cord-259748-x7dq1sy4	371	7	cells	cell	NNS
cord-259748-x7dq1sy4	371	8	express	express	VBP
cord-259748-x7dq1sy4	371	9	STING	sting	NN
cord-259748-x7dq1sy4	371	10	variously	variously	RB
cord-259748-x7dq1sy4	371	11	and	and	CC
cord-259748-x7dq1sy4	371	12	may	may	MD
cord-259748-x7dq1sy4	371	13	undergo	undergo	VB
cord-259748-x7dq1sy4	371	14	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	371	15	through	through	IN
cord-259748-x7dq1sy4	371	16	this	this	DT
cord-259748-x7dq1sy4	371	17	way	way	NN
cord-259748-x7dq1sy4	371	18	(	(	-LRB-
cord-259748-x7dq1sy4	371	19	166	166	CD
cord-259748-x7dq1sy4	371	20	,	,	,
cord-259748-x7dq1sy4	371	21	216	216	CD
cord-259748-x7dq1sy4	371	22	,	,	,
cord-259748-x7dq1sy4	371	23	217	217	CD
cord-259748-x7dq1sy4	371	24	)	)	-RRB-
cord-259748-x7dq1sy4	371	25	.	.	.
cord-259748-x7dq1sy4	372	1	However	however	RB
cord-259748-x7dq1sy4	372	2	,	,	,
cord-259748-x7dq1sy4	372	3	simultaneous	simultaneous	JJ
cord-259748-x7dq1sy4	372	4	signaling	signaling	NN
cord-259748-x7dq1sy4	372	5	by	by	IN
cord-259748-x7dq1sy4	372	6	STING	sting	NN
cord-259748-x7dq1sy4	372	7	and	and	CC
cord-259748-x7dq1sy4	372	8	the	the	DT
cord-259748-x7dq1sy4	372	9	B	b	NN
cord-259748-x7dq1sy4	372	10	-	-	HYPH
cord-259748-x7dq1sy4	372	11	cell	cell	NN
cord-259748-x7dq1sy4	372	12	antigen	antigen	NN
cord-259748-x7dq1sy4	372	13	receptor	receptor	NN
cord-259748-x7dq1sy4	372	14	can	can	MD
cord-259748-x7dq1sy4	372	15	promote	promote	VB
cord-259748-x7dq1sy4	372	16	B	b	NN
cord-259748-x7dq1sy4	372	17	-	-	HYPH
cord-259748-x7dq1sy4	372	18	cell	cell	NN
cord-259748-x7dq1sy4	372	19	activation	activation	NN
cord-259748-x7dq1sy4	372	20	and	and	CC
cord-259748-x7dq1sy4	372	21	antibody	antibody	NN
cord-259748-x7dq1sy4	372	22	production	production	NN
cord-259748-x7dq1sy4	372	23	independently	independently	RB
cord-259748-x7dq1sy4	372	24	of	of	IN
cord-259748-x7dq1sy4	372	25	type	type	NN
cord-259748-x7dq1sy4	372	26	-	-	:
cord-259748-x7dq1sy4	372	27	I	-PRON-	PRP
cord-259748-x7dq1sy4	372	28	IFN	IFN	NNP
cord-259748-x7dq1sy4	372	29	(	(	-LRB-
cord-259748-x7dq1sy4	372	30	217	217	CD
cord-259748-x7dq1sy4	372	31	)	)	-RRB-
cord-259748-x7dq1sy4	372	32	(	(	-LRB-
cord-259748-x7dq1sy4	372	33	Figure	figure	NN
cord-259748-x7dq1sy4	372	34	4B	4b	NN
cord-259748-x7dq1sy4	372	35	)	)	-RRB-
cord-259748-x7dq1sy4	372	36	.	.	.
cord-259748-x7dq1sy4	373	1	As	as	IN
cord-259748-x7dq1sy4	373	2	for	for	IN
cord-259748-x7dq1sy4	373	3	some	some	DT
cord-259748-x7dq1sy4	373	4	diseases	disease	NNS
cord-259748-x7dq1sy4	373	5	with	with	IN
cord-259748-x7dq1sy4	373	6	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	373	7	responses	response	NNS
cord-259748-x7dq1sy4	373	8	involved	involve	VBN
cord-259748-x7dq1sy4	373	9	,	,	,
cord-259748-x7dq1sy4	373	10	the	the	DT
cord-259748-x7dq1sy4	373	11	acute	acute	JJ
cord-259748-x7dq1sy4	373	12	phase	phase	NN
cord-259748-x7dq1sy4	373	13	of	of	IN
cord-259748-x7dq1sy4	373	14	pancreatitis	pancreatitis	NN
cord-259748-x7dq1sy4	373	15	causes	cause	NNS
cord-259748-x7dq1sy4	373	16	dying	die	VBG
cord-259748-x7dq1sy4	373	17	acinar	acinar	NN
cord-259748-x7dq1sy4	373	18	cells	cell	NNS
cord-259748-x7dq1sy4	373	19	to	to	TO
cord-259748-x7dq1sy4	373	20	produce	produce	VB
cord-259748-x7dq1sy4	373	21	free	free	JJ
cord-259748-x7dq1sy4	373	22	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	373	23	,	,	,
cord-259748-x7dq1sy4	373	24	which	which	WDT
cord-259748-x7dq1sy4	373	25	activates	activate	VBZ
cord-259748-x7dq1sy4	373	26	cGAS	cgas	JJ
cord-259748-x7dq1sy4	373	27	-	-	HYPH
cord-259748-x7dq1sy4	373	28	STING	sting	NN
cord-259748-x7dq1sy4	373	29	signaling	signaling	NN
cord-259748-x7dq1sy4	373	30	in	in	IN
cord-259748-x7dq1sy4	373	31	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	373	32	,	,	,
cord-259748-x7dq1sy4	373	33	and	and	CC
cord-259748-x7dq1sy4	373	34	exacerbates	exacerbate	VBZ
cord-259748-x7dq1sy4	373	35	inflammation	inflammation	NN
cord-259748-x7dq1sy4	373	36	severity	severity	NN
cord-259748-x7dq1sy4	373	37	(	(	-LRB-
cord-259748-x7dq1sy4	373	38	218	218	CD
cord-259748-x7dq1sy4	373	39	)	)	-RRB-
cord-259748-x7dq1sy4	373	40	.	.	.
cord-259748-x7dq1sy4	374	1	However	however	RB
cord-259748-x7dq1sy4	374	2	,	,	,
cord-259748-x7dq1sy4	374	3	in	in	IN
cord-259748-x7dq1sy4	374	4	the	the	DT
cord-259748-x7dq1sy4	374	5	chronic	chronic	JJ
cord-259748-x7dq1sy4	374	6	phase	phase	NN
cord-259748-x7dq1sy4	374	7	of	of	IN
cord-259748-x7dq1sy4	374	8	pancreatitis	pancreatitis	NN
cord-259748-x7dq1sy4	374	9	,	,	,
cord-259748-x7dq1sy4	374	10	cGAS	cgas	JJ
cord-259748-x7dq1sy4	374	11	-	-	HYPH
cord-259748-x7dq1sy4	374	12	STING	sting	NN
cord-259748-x7dq1sy4	374	13	activation	activation	NN
cord-259748-x7dq1sy4	374	14	decreases	decrease	VBZ
cord-259748-x7dq1sy4	374	15	pancreatic	pancreatic	JJ
cord-259748-x7dq1sy4	374	16	inflammation	inflammation	NN
cord-259748-x7dq1sy4	374	17	,	,	,
cord-259748-x7dq1sy4	374	18	which	which	WDT
cord-259748-x7dq1sy4	374	19	may	may	MD
cord-259748-x7dq1sy4	374	20	be	be	VB
cord-259748-x7dq1sy4	374	21	mediated	mediate	VBN
cord-259748-x7dq1sy4	374	22	by	by	IN
cord-259748-x7dq1sy4	374	23	limiting	limit	VBG
cord-259748-x7dq1sy4	374	24	T	T	NNP
cord-259748-x7dq1sy4	374	25	h	h	NNP
cord-259748-x7dq1sy4	374	26	17	17	CD
cord-259748-x7dq1sy4	374	27	response	response	NN
cord-259748-x7dq1sy4	374	28	(	(	-LRB-
cord-259748-x7dq1sy4	374	29	219	219	CD
cord-259748-x7dq1sy4	374	30	)	)	-RRB-
cord-259748-x7dq1sy4	374	31	.	.	.
cord-259748-x7dq1sy4	375	1	For	for	IN
cord-259748-x7dq1sy4	375	2	gut	gut	NN
cord-259748-x7dq1sy4	375	3	mucosal	mucosal	JJ
cord-259748-x7dq1sy4	375	4	immunity	immunity	NN
cord-259748-x7dq1sy4	375	5	,	,	,
cord-259748-x7dq1sy4	375	6	transient	transient	JJ
cord-259748-x7dq1sy4	375	7	stimulation	stimulation	NN
cord-259748-x7dq1sy4	375	8	of	of	IN
cord-259748-x7dq1sy4	375	9	STING	sting	NN
cord-259748-x7dq1sy4	375	10	could	could	MD
cord-259748-x7dq1sy4	375	11	strengthen	strengthen	VB
cord-259748-x7dq1sy4	375	12	the	the	DT
cord-259748-x7dq1sy4	375	13	function	function	NN
cord-259748-x7dq1sy4	375	14	of	of	IN
cord-259748-x7dq1sy4	375	15	antigen	antigen	NN
cord-259748-x7dq1sy4	375	16	-	-	HYPH
cord-259748-x7dq1sy4	375	17	presenting	present	VBG
cord-259748-x7dq1sy4	375	18	cells	cell	NNS
cord-259748-x7dq1sy4	375	19	(	(	-LRB-
cord-259748-x7dq1sy4	375	20	APCs	apc	NNS
cord-259748-x7dq1sy4	375	21	)	)	-RRB-
cord-259748-x7dq1sy4	375	22	and	and	CC
cord-259748-x7dq1sy4	375	23	promote	promote	VB
cord-259748-x7dq1sy4	375	24	T	T	NNP
cord-259748-x7dq1sy4	375	25	h	h	NN
cord-259748-x7dq1sy4	375	26	1	1	CD
cord-259748-x7dq1sy4	375	27	and	and	CC
cord-259748-x7dq1sy4	375	28	T	T	NNP
cord-259748-x7dq1sy4	375	29	h	h	NNP
cord-259748-x7dq1sy4	375	30	17	17	CD
cord-259748-x7dq1sy4	375	31	immune	immune	JJ
cord-259748-x7dq1sy4	375	32	responses	response	NNS
cord-259748-x7dq1sy4	375	33	against	against	IN
cord-259748-x7dq1sy4	375	34	microbes	microbe	NNS
cord-259748-x7dq1sy4	375	35	(	(	-LRB-
cord-259748-x7dq1sy4	375	36	220	220	CD
cord-259748-x7dq1sy4	375	37	)	)	-RRB-
cord-259748-x7dq1sy4	375	38	.	.	.
cord-259748-x7dq1sy4	376	1	Chronic	chronic	JJ
cord-259748-x7dq1sy4	376	2	STING	sting	NN
cord-259748-x7dq1sy4	376	3	signaling	signal	VBG
cord-259748-x7dq1sy4	376	4	,	,	,
cord-259748-x7dq1sy4	376	5	however	however	RB
cord-259748-x7dq1sy4	376	6	,	,	,
cord-259748-x7dq1sy4	376	7	elicits	elicit	VBZ
cord-259748-x7dq1sy4	376	8	an	an	DT
cord-259748-x7dq1sy4	376	9	IL-10	IL-10	NNP
cord-259748-x7dq1sy4	376	10	response	response	NN
cord-259748-x7dq1sy4	376	11	to	to	TO
cord-259748-x7dq1sy4	376	12	control	control	VB
cord-259748-x7dq1sy4	376	13	the	the	DT
cord-259748-x7dq1sy4	376	14	inflammation	inflammation	NN
cord-259748-x7dq1sy4	376	15	and	and	CC
cord-259748-x7dq1sy4	376	16	avoids	avoid	VBZ
cord-259748-x7dq1sy4	376	17	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	376	18	enterocolitis	enterocolitis	NN
cord-259748-x7dq1sy4	376	19	such	such	JJ
cord-259748-x7dq1sy4	376	20	as	as	IN
cord-259748-x7dq1sy4	376	21	bowel	bowel	NN
cord-259748-x7dq1sy4	376	22	disease	disease	NN
cord-259748-x7dq1sy4	376	23	(	(	-LRB-
cord-259748-x7dq1sy4	376	24	221	221	CD
cord-259748-x7dq1sy4	376	25	)	)	-RRB-
cord-259748-x7dq1sy4	376	26	.	.	.
cord-259748-x7dq1sy4	377	1	STING	sting	VB
cord-259748-x7dq1sy4	377	2	knockout	knockout	NN
cord-259748-x7dq1sy4	377	3	mice	mouse	NNS
cord-259748-x7dq1sy4	377	4	present	present	JJ
cord-259748-x7dq1sy4	377	5	reduced	reduce	VBN
cord-259748-x7dq1sy4	377	6	numbers	number	NNS
cord-259748-x7dq1sy4	377	7	of	of	IN
cord-259748-x7dq1sy4	377	8	goblet	goblet	NN
cord-259748-x7dq1sy4	377	9	cells	cell	NNS
cord-259748-x7dq1sy4	377	10	,	,	,
cord-259748-x7dq1sy4	377	11	a	a	DT
cord-259748-x7dq1sy4	377	12	decreased	decrease	VBN
cord-259748-x7dq1sy4	377	13	ratio	ratio	NN
cord-259748-x7dq1sy4	377	14	of	of	IN
cord-259748-x7dq1sy4	377	15	commensal	commensal	JJ
cord-259748-x7dq1sy4	377	16	versus	versus	IN
cord-259748-x7dq1sy4	377	17	harmful	harmful	JJ
cord-259748-x7dq1sy4	377	18	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	377	19	and	and	CC
cord-259748-x7dq1sy4	377	20	compromised	compromise	VBN
cord-259748-x7dq1sy4	377	21	T	T	NNP
cord-259748-x7dq1sy4	377	22	reg	reg	NN
cord-259748-x7dq1sy4	377	23	cells	cell	NNS
cord-259748-x7dq1sy4	377	24	in	in	IN
cord-259748-x7dq1sy4	377	25	the	the	DT
cord-259748-x7dq1sy4	377	26	gut	gut	NN
cord-259748-x7dq1sy4	377	27	,	,	,
cord-259748-x7dq1sy4	377	28	making	make	VBG
cord-259748-x7dq1sy4	377	29	it	-PRON-	PRP
cord-259748-x7dq1sy4	377	30	prone	prone	JJ
cord-259748-x7dq1sy4	377	31	to	to	IN
cord-259748-x7dq1sy4	377	32	enterocolitis	enterocolitis	NN
cord-259748-x7dq1sy4	377	33	(	(	-LRB-
cord-259748-x7dq1sy4	377	34	222	222	CD
cord-259748-x7dq1sy4	377	35	)	)	-RRB-
cord-259748-x7dq1sy4	377	36	.	.	.
cord-259748-x7dq1sy4	378	1	Chromosomal	chromosomal	JJ
cord-259748-x7dq1sy4	378	2	instability	instability	NN
cord-259748-x7dq1sy4	378	3	(	(	-LRB-
cord-259748-x7dq1sy4	378	4	CIN	CIN	NNP
cord-259748-x7dq1sy4	378	5	)	)	-RRB-
cord-259748-x7dq1sy4	378	6	is	be	VBZ
cord-259748-x7dq1sy4	378	7	an	an	DT
cord-259748-x7dq1sy4	378	8	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	378	9	feature	feature	NN
cord-259748-x7dq1sy4	378	10	of	of	IN
cord-259748-x7dq1sy4	378	11	cancer	cancer	NN
cord-259748-x7dq1sy4	378	12	,	,	,
cord-259748-x7dq1sy4	378	13	and	and	CC
cord-259748-x7dq1sy4	378	14	results	result	VBZ
cord-259748-x7dq1sy4	378	15	spontaneously	spontaneously	RB
cord-259748-x7dq1sy4	378	16	from	from	IN
cord-259748-x7dq1sy4	378	17	errors	error	NNS
cord-259748-x7dq1sy4	378	18	in	in	IN
cord-259748-x7dq1sy4	378	19	chromosome	chromosome	NN
cord-259748-x7dq1sy4	378	20	segregation	segregation	NN
cord-259748-x7dq1sy4	378	21	during	during	IN
cord-259748-x7dq1sy4	378	22	the	the	DT
cord-259748-x7dq1sy4	378	23	mitosis	mitosis	NN
cord-259748-x7dq1sy4	378	24	of	of	IN
cord-259748-x7dq1sy4	378	25	cancer	cancer	NN
cord-259748-x7dq1sy4	378	26	cells	cell	NNS
cord-259748-x7dq1sy4	378	27	.	.	.
cord-259748-x7dq1sy4	379	1	CIN	CIN	NNP
cord-259748-x7dq1sy4	379	2	can	can	MD
cord-259748-x7dq1sy4	379	3	also	also	RB
cord-259748-x7dq1sy4	379	4	be	be	VB
cord-259748-x7dq1sy4	379	5	induced	induce	VBN
cord-259748-x7dq1sy4	379	6	manually	manually	RB
cord-259748-x7dq1sy4	379	7	by	by	IN
cord-259748-x7dq1sy4	379	8	radiotherapy	radiotherapy	NN
cord-259748-x7dq1sy4	379	9	or	or	CC
cord-259748-x7dq1sy4	379	10	chemotherapy	chemotherapy	NN
cord-259748-x7dq1sy4	379	11	,	,	,
cord-259748-x7dq1sy4	379	12	which	which	WDT
cord-259748-x7dq1sy4	379	13	causes	cause	VBZ
cord-259748-x7dq1sy4	379	14	DSBs	dsb	NNS
cord-259748-x7dq1sy4	379	15	.	.	.
cord-259748-x7dq1sy4	380	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	380	2	results	result	VBZ
cord-259748-x7dq1sy4	380	3	in	in	IN
cord-259748-x7dq1sy4	380	4	micronuclei	micronuclei	NNP
cord-259748-x7dq1sy4	380	5	formation	formation	NN
cord-259748-x7dq1sy4	380	6	outside	outside	IN
cord-259748-x7dq1sy4	380	7	the	the	DT
cord-259748-x7dq1sy4	380	8	nucleus	nucleus	NN
cord-259748-x7dq1sy4	380	9	,	,	,
cord-259748-x7dq1sy4	380	10	of	of	IN
cord-259748-x7dq1sy4	380	11	which	which	WDT
cord-259748-x7dq1sy4	380	12	rupture	rupture	NN
cord-259748-x7dq1sy4	380	13	brings	bring	VBZ
cord-259748-x7dq1sy4	380	14	out	out	RP
cord-259748-x7dq1sy4	380	15	irrepressible	irrepressible	JJ
cord-259748-x7dq1sy4	380	16	accumulation	accumulation	NN
cord-259748-x7dq1sy4	380	17	of	of	IN
cord-259748-x7dq1sy4	380	18	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	380	19	self	self	NN
cord-259748-x7dq1sy4	380	20	-	-	HYPH
cord-259748-x7dq1sy4	380	21	DNA	dna	NN
cord-259748-x7dq1sy4	380	22	and	and	CC
cord-259748-x7dq1sy4	380	23	engages	engage	VBZ
cord-259748-x7dq1sy4	380	24	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	380	25	(	(	-LRB-
cord-259748-x7dq1sy4	380	26	32	32	CD
cord-259748-x7dq1sy4	380	27	,	,	,
cord-259748-x7dq1sy4	380	28	38	38	CD
cord-259748-x7dq1sy4	380	29	,	,	,
cord-259748-x7dq1sy4	380	30	223	223	CD
cord-259748-x7dq1sy4	380	31	)	)	-RRB-
cord-259748-x7dq1sy4	380	32	.	.	.
cord-259748-x7dq1sy4	381	1	However	however	RB
cord-259748-x7dq1sy4	381	2	,	,	,
cord-259748-x7dq1sy4	381	3	normal	normal	JJ
cord-259748-x7dq1sy4	381	4	mitotic	mitotic	JJ
cord-259748-x7dq1sy4	381	5	processes	process	NNS
cord-259748-x7dq1sy4	381	6	involve	involve	VBP
cord-259748-x7dq1sy4	381	7	exposure	exposure	NN
cord-259748-x7dq1sy4	381	8	of	of	IN
cord-259748-x7dq1sy4	381	9	chromosomal	chromosomal	JJ
cord-259748-x7dq1sy4	381	10	DNA	dna	NN
cord-259748-x7dq1sy4	381	11	to	to	IN
cord-259748-x7dq1sy4	381	12	the	the	DT
cord-259748-x7dq1sy4	381	13	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	381	14	,	,	,
cord-259748-x7dq1sy4	381	15	but	but	CC
cord-259748-x7dq1sy4	381	16	this	this	DT
cord-259748-x7dq1sy4	381	17	can	can	MD
cord-259748-x7dq1sy4	381	18	not	not	RB
cord-259748-x7dq1sy4	381	19	initiate	initiate	VB
cord-259748-x7dq1sy4	381	20	a	a	DT
cord-259748-x7dq1sy4	381	21	substantial	substantial	JJ
cord-259748-x7dq1sy4	381	22	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	381	23	reaction	reaction	NN
cord-259748-x7dq1sy4	381	24	or	or	CC
cord-259748-x7dq1sy4	381	25	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	381	26	because	because	IN
cord-259748-x7dq1sy4	381	27	nucleosomes	nucleosome	NNS
cord-259748-x7dq1sy4	381	28	can	can	MD
cord-259748-x7dq1sy4	381	29	suppress	suppress	VB
cord-259748-x7dq1sy4	381	30	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	381	31	-	-	HYPH
cord-259748-x7dq1sy4	381	32	cGAS	cgas	JJ
cord-259748-x7dq1sy4	381	33	binding	binding	NN
cord-259748-x7dq1sy4	381	34	in	in	IN
cord-259748-x7dq1sy4	381	35	a	a	DT
cord-259748-x7dq1sy4	381	36	competitive	competitive	JJ
cord-259748-x7dq1sy4	381	37	manner	manner	NN
cord-259748-x7dq1sy4	381	38	(	(	-LRB-
cord-259748-x7dq1sy4	381	39	41	41	CD
cord-259748-x7dq1sy4	381	40	)	)	-RRB-
cord-259748-x7dq1sy4	381	41	.	.	.
cord-259748-x7dq1sy4	382	1	An	an	DT
cord-259748-x7dq1sy4	382	2	appropriate	appropriate	JJ
cord-259748-x7dq1sy4	382	3	immune	immune	JJ
cord-259748-x7dq1sy4	382	4	response	response	NN
cord-259748-x7dq1sy4	382	5	against	against	IN
cord-259748-x7dq1sy4	382	6	tumors	tumor	NNS
cord-259748-x7dq1sy4	382	7	via	via	IN
cord-259748-x7dq1sy4	382	8	a	a	DT
cord-259748-x7dq1sy4	382	9	type	type	NN
cord-259748-x7dq1sy4	383	1	-I	-I	NFP
cord-259748-x7dq1sy4	383	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	383	3	plays	play	VBZ
cord-259748-x7dq1sy4	383	4	an	an	DT
cord-259748-x7dq1sy4	383	5	indispensable	indispensable	JJ
cord-259748-x7dq1sy4	383	6	part	part	NN
cord-259748-x7dq1sy4	383	7	in	in	IN
cord-259748-x7dq1sy4	383	8	limiting	limit	VBG
cord-259748-x7dq1sy4	383	9	tumors	tumor	NNS
cord-259748-x7dq1sy4	383	10	and	and	CC
cord-259748-x7dq1sy4	383	11	prolonging	prolong	VBG
cord-259748-x7dq1sy4	383	12	host	host	NN
cord-259748-x7dq1sy4	383	13	survival	survival	NN
cord-259748-x7dq1sy4	383	14	(	(	-LRB-
cord-259748-x7dq1sy4	383	15	224	224	CD
cord-259748-x7dq1sy4	383	16	)	)	-RRB-
cord-259748-x7dq1sy4	383	17	.	.	.
cord-259748-x7dq1sy4	384	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	384	2	was	be	VBD
cord-259748-x7dq1sy4	384	3	found	find	VBN
cord-259748-x7dq1sy4	384	4	STING	sting	NN
cord-259748-x7dq1sy4	384	5	-	-	HYPH
cord-259748-x7dq1sy4	384	6	deficient	deficient	JJ
cord-259748-x7dq1sy4	384	7	mice	mouse	NNS
cord-259748-x7dq1sy4	384	8	are	be	VBP
cord-259748-x7dq1sy4	384	9	prone	prone	JJ
cord-259748-x7dq1sy4	384	10	to	to	IN
cord-259748-x7dq1sy4	384	11	developing	develop	VBG
cord-259748-x7dq1sy4	384	12	several	several	JJ
cord-259748-x7dq1sy4	384	13	types	type	NNS
cord-259748-x7dq1sy4	384	14	of	of	IN
cord-259748-x7dq1sy4	384	15	cancer	cancer	NN
cord-259748-x7dq1sy4	384	16	and	and	CC
cord-259748-x7dq1sy4	384	17	have	have	VBP
cord-259748-x7dq1sy4	384	18	poor	poor	JJ
cord-259748-x7dq1sy4	384	19	survival	survival	NN
cord-259748-x7dq1sy4	384	20	under	under	IN
cord-259748-x7dq1sy4	384	21	a	a	DT
cord-259748-x7dq1sy4	384	22	tumor	tumor	NN
cord-259748-x7dq1sy4	384	23	burden	burden	NN
cord-259748-x7dq1sy4	384	24	,	,	,
cord-259748-x7dq1sy4	384	25	whereas	whereas	IN
cord-259748-x7dq1sy4	384	26	stimulation	stimulation	NN
cord-259748-x7dq1sy4	384	27	of	of	IN
cord-259748-x7dq1sy4	384	28	STING	sting	NN
cord-259748-x7dq1sy4	384	29	can	can	MD
cord-259748-x7dq1sy4	384	30	elicit	elicit	VB
cord-259748-x7dq1sy4	384	31	robust	robust	JJ
cord-259748-x7dq1sy4	384	32	immunity	immunity	NN
cord-259748-x7dq1sy4	384	33	to	to	IN
cord-259748-x7dq1sy4	384	34	tumors	tumor	NNS
cord-259748-x7dq1sy4	384	35	(	(	-LRB-
cord-259748-x7dq1sy4	384	36	225	225	CD
cord-259748-x7dq1sy4	384	37	)	)	-RRB-
cord-259748-x7dq1sy4	384	38	(	(	-LRB-
cord-259748-x7dq1sy4	384	39	226	226	CD
cord-259748-x7dq1sy4	384	40	)	)	-RRB-
cord-259748-x7dq1sy4	384	41	(	(	-LRB-
cord-259748-x7dq1sy4	384	42	227	227	CD
cord-259748-x7dq1sy4	384	43	)	)	-RRB-
cord-259748-x7dq1sy4	384	44	.	.	.
cord-259748-x7dq1sy4	385	1	A	a	DT
cord-259748-x7dq1sy4	385	2	mechanism	mechanism	NN
cord-259748-x7dq1sy4	385	3	is	be	VBZ
cord-259748-x7dq1sy4	385	4	many	many	JJ
cord-259748-x7dq1sy4	385	5	cancer	cancer	NN
cord-259748-x7dq1sy4	385	6	cells	cell	NNS
cord-259748-x7dq1sy4	385	7	expressing	express	VBG
cord-259748-x7dq1sy4	385	8	cGAS	cgas	NN
cord-259748-x7dq1sy4	385	9	can	can	MD
cord-259748-x7dq1sy4	385	10	recognize	recognize	VB
cord-259748-x7dq1sy4	385	11	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	385	12	DNA	dna	NN
cord-259748-x7dq1sy4	385	13	and	and	CC
cord-259748-x7dq1sy4	385	14	produce	produce	VB
cord-259748-x7dq1sy4	385	15	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	385	16	to	to	TO
cord-259748-x7dq1sy4	385	17	stimulate	stimulate	VB
cord-259748-x7dq1sy4	385	18	secretion	secretion	NN
cord-259748-x7dq1sy4	385	19	of	of	IN
cord-259748-x7dq1sy4	385	20	type	type	NN
cord-259748-x7dq1sy4	385	21	-	-	:
cord-259748-x7dq1sy4	385	22	I	-PRON-	PRP
cord-259748-x7dq1sy4	385	23	IFN	IFN	NNP
cord-259748-x7dq1sy4	385	24	through	through	IN
cord-259748-x7dq1sy4	385	25	STING	sting	NN
cord-259748-x7dq1sy4	385	26	(	(	-LRB-
cord-259748-x7dq1sy4	385	27	228	228	CD
cord-259748-x7dq1sy4	385	28	,	,	,
cord-259748-x7dq1sy4	385	29	229	229	CD
cord-259748-x7dq1sy4	385	30	)	)	-RRB-
cord-259748-x7dq1sy4	385	31	.	.	.
cord-259748-x7dq1sy4	386	1	Excessive	excessive	JJ
cord-259748-x7dq1sy4	386	2	expression	expression	NN
cord-259748-x7dq1sy4	386	3	of	of	IN
cord-259748-x7dq1sy4	386	4	TREX1	trex1	NN
cord-259748-x7dq1sy4	386	5	in	in	IN
cord-259748-x7dq1sy4	386	6	cancer	cancer	NN
cord-259748-x7dq1sy4	386	7	cells	cell	NNS
cord-259748-x7dq1sy4	386	8	,	,	,
cord-259748-x7dq1sy4	386	9	which	which	WDT
cord-259748-x7dq1sy4	386	10	can	can	MD
cord-259748-x7dq1sy4	386	11	be	be	VB
cord-259748-x7dq1sy4	386	12	induced	induce	VBN
cord-259748-x7dq1sy4	386	13	by	by	IN
cord-259748-x7dq1sy4	386	14	radiotherapy	radiotherapy	NN
cord-259748-x7dq1sy4	386	15	,	,	,
cord-259748-x7dq1sy4	386	16	attenuates	attenuate	VBZ
cord-259748-x7dq1sy4	386	17	this	this	DT
cord-259748-x7dq1sy4	386	18	progression	progression	NN
cord-259748-x7dq1sy4	386	19	(	(	-LRB-
cord-259748-x7dq1sy4	386	20	228	228	CD
cord-259748-x7dq1sy4	386	21	)	)	-RRB-
cord-259748-x7dq1sy4	386	22	.	.	.
cord-259748-x7dq1sy4	387	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	387	2	-	-	:
cord-259748-x7dq1sy4	387	3	STING	sting	NN
cord-259748-x7dq1sy4	387	4	can	can	MD
cord-259748-x7dq1sy4	387	5	also	also	RB
cord-259748-x7dq1sy4	387	6	promote	promote	VB
cord-259748-x7dq1sy4	387	7	senescence	senescence	NN
cord-259748-x7dq1sy4	387	8	of	of	IN
cord-259748-x7dq1sy4	387	9	cancer	cancer	NN
cord-259748-x7dq1sy4	387	10	cells	cell	NNS
cord-259748-x7dq1sy4	387	11	through	through	IN
cord-259748-x7dq1sy4	387	12	the	the	DT
cord-259748-x7dq1sy4	387	13	p53-p21	p53-p21	NNP
cord-259748-x7dq1sy4	387	14	pathway	pathway	NN
cord-259748-x7dq1sy4	387	15	(	(	-LRB-
cord-259748-x7dq1sy4	387	16	129	129	CD
cord-259748-x7dq1sy4	387	17	)	)	-RRB-
cord-259748-x7dq1sy4	387	18	.	.	.
cord-259748-x7dq1sy4	388	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	388	2	-	-	HYPH
cord-259748-x7dq1sy4	388	3	STING	sting	NN
cord-259748-x7dq1sy4	388	4	-	-	HYPH
cord-259748-x7dq1sy4	388	5	mediated	mediate	VBN
cord-259748-x7dq1sy4	388	6	autophagy	autophagy	NN
cord-259748-x7dq1sy4	388	7	contributes	contribute	VBZ
cord-259748-x7dq1sy4	388	8	to	to	TO
cord-259748-x7dq1sy4	388	9	autophagic	autophagic	VB
cord-259748-x7dq1sy4	388	10	cell	cell	NN
cord-259748-x7dq1sy4	388	11	death	death	NN
cord-259748-x7dq1sy4	388	12	if	if	IN
cord-259748-x7dq1sy4	388	13	mitotic	mitotic	JJ
cord-259748-x7dq1sy4	388	14	crisis	crisis	NN
cord-259748-x7dq1sy4	388	15	occurs	occur	VBZ
cord-259748-x7dq1sy4	388	16	to	to	TO
cord-259748-x7dq1sy4	388	17	avoid	avoid	VB
cord-259748-x7dq1sy4	388	18	transformation	transformation	NN
cord-259748-x7dq1sy4	388	19	of	of	IN
cord-259748-x7dq1sy4	388	20	cancer	cancer	NN
cord-259748-x7dq1sy4	388	21	cells	cell	NNS
cord-259748-x7dq1sy4	388	22	(	(	-LRB-
cord-259748-x7dq1sy4	388	23	121	121	CD
cord-259748-x7dq1sy4	388	24	)	)	-RRB-
cord-259748-x7dq1sy4	388	25	.	.	.
cord-259748-x7dq1sy4	389	1	Melanoma	melanoma	NN
cord-259748-x7dq1sy4	389	2	cells	cell	NNS
cord-259748-x7dq1sy4	389	3	can	can	MD
cord-259748-x7dq1sy4	389	4	also	also	RB
cord-259748-x7dq1sy4	389	5	transfer	transfer	VB
cord-259748-x7dq1sy4	389	6	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	389	7	produced	produce	VBN
cord-259748-x7dq1sy4	389	8	by	by	IN
cord-259748-x7dq1sy4	389	9	them	-PRON-	PRP
cord-259748-x7dq1sy4	389	10	to	to	IN
cord-259748-x7dq1sy4	389	11	proximal	proximal	JJ
cord-259748-x7dq1sy4	389	12	non	non	JJ
cord-259748-x7dq1sy4	389	13	-	-	JJ
cord-259748-x7dq1sy4	389	14	cancerous	cancerous	JJ
cord-259748-x7dq1sy4	389	15	host	host	NN
cord-259748-x7dq1sy4	389	16	cells	cell	NNS
cord-259748-x7dq1sy4	389	17	through	through	IN
cord-259748-x7dq1sy4	389	18	gap	gap	NN
cord-259748-x7dq1sy4	389	19	-	-	HYPH
cord-259748-x7dq1sy4	389	20	junction	junction	NN
cord-259748-x7dq1sy4	389	21	channels	channel	NNS
cord-259748-x7dq1sy4	389	22	and	and	CC
cord-259748-x7dq1sy4	389	23	activate	activate	VB
cord-259748-x7dq1sy4	389	24	STING	sting	NN
cord-259748-x7dq1sy4	389	25	in	in	IN
cord-259748-x7dq1sy4	389	26	these	these	DT
cord-259748-x7dq1sy4	389	27	cells	cell	NNS
cord-259748-x7dq1sy4	389	28	,	,	,
cord-259748-x7dq1sy4	389	29	which	which	WDT
cord-259748-x7dq1sy4	389	30	contributes	contribute	VBZ
cord-259748-x7dq1sy4	389	31	to	to	IN
cord-259748-x7dq1sy4	389	32	the	the	DT
cord-259748-x7dq1sy4	389	33	recruitment	recruitment	NN
cord-259748-x7dq1sy4	389	34	of	of	IN
cord-259748-x7dq1sy4	389	35	tumor	tumor	NN
cord-259748-x7dq1sy4	389	36	-	-	HYPH
cord-259748-x7dq1sy4	389	37	infiltrating	infiltrate	VBG
cord-259748-x7dq1sy4	389	38	immune	immune	JJ
cord-259748-x7dq1sy4	389	39	cells	cell	NNS
cord-259748-x7dq1sy4	389	40	such	such	JJ
cord-259748-x7dq1sy4	389	41	as	as	IN
cord-259748-x7dq1sy4	389	42	natural	natural	JJ
cord-259748-x7dq1sy4	389	43	killer	killer	NN
cord-259748-x7dq1sy4	389	44	(	(	-LRB-
cord-259748-x7dq1sy4	389	45	NK	NK	NNP
cord-259748-x7dq1sy4	389	46	)	)	-RRB-
cord-259748-x7dq1sy4	389	47	cells	cell	NNS
cord-259748-x7dq1sy4	389	48	(	(	-LRB-
cord-259748-x7dq1sy4	389	49	51	51	CD
cord-259748-x7dq1sy4	389	50	,	,	,
cord-259748-x7dq1sy4	389	51	230	230	CD
cord-259748-x7dq1sy4	389	52	)	)	-RRB-
cord-259748-x7dq1sy4	389	53	.	.	.
cord-259748-x7dq1sy4	390	1	Expression	expression	NN
cord-259748-x7dq1sy4	390	2	of	of	IN
cord-259748-x7dq1sy4	390	3	the	the	DT
cord-259748-x7dq1sy4	390	4	NK	NK	NNP
cord-259748-x7dq1sy4	390	5	cellspecific	cellspecific	NN
cord-259748-x7dq1sy4	390	6	ligand	ligand	NN
cord-259748-x7dq1sy4	390	7	NKG2D	NKG2D	NNP
cord-259748-x7dq1sy4	391	1	retinoic	retinoic	JJ
cord-259748-x7dq1sy4	391	2	acid	acid	NN
cord-259748-x7dq1sy4	392	1	early	early	JJ
cord-259748-x7dq1sy4	392	2	transcript	transcript	NN
cord-259748-x7dq1sy4	392	3	1	1	CD
cord-259748-x7dq1sy4	392	4	(	(	-LRB-
cord-259748-x7dq1sy4	392	5	RAE1	RAE1	NNP
cord-259748-x7dq1sy4	392	6	)	)	-RRB-
cord-259748-x7dq1sy4	392	7	on	on	IN
cord-259748-x7dq1sy4	392	8	cancer	cancer	NN
cord-259748-x7dq1sy4	392	9	cells	cell	NNS
cord-259748-x7dq1sy4	392	10	is	be	VBZ
cord-259748-x7dq1sy4	392	11	highly	highly	RB
cord-259748-x7dq1sy4	392	12	up	up	RB
cord-259748-x7dq1sy4	392	13	-	-	HYPH
cord-259748-x7dq1sy4	392	14	regulated	regulate	VBN
cord-259748-x7dq1sy4	392	15	by	by	IN
cord-259748-x7dq1sy4	392	16	STING	sting	NN
cord-259748-x7dq1sy4	392	17	once	once	IN
cord-259748-x7dq1sy4	392	18	NK	NK	NNP
cord-259748-x7dq1sy4	392	19	cells	cell	NNS
cord-259748-x7dq1sy4	392	20	permeate	permeate	VBP
cord-259748-x7dq1sy4	392	21	into	into	IN
cord-259748-x7dq1sy4	392	22	tumor	tumor	NN
cord-259748-x7dq1sy4	392	23	tissue	tissue	NN
cord-259748-x7dq1sy4	392	24	(	(	-LRB-
cord-259748-x7dq1sy4	392	25	231	231	CD
cord-259748-x7dq1sy4	392	26	)	)	-RRB-
cord-259748-x7dq1sy4	392	27	.	.	.
cord-259748-x7dq1sy4	393	1	The	the	DT
cord-259748-x7dq1sy4	393	2	activation	activation	NN
cord-259748-x7dq1sy4	393	3	of	of	IN
cord-259748-x7dq1sy4	393	4	STING	sting	NN
cord-259748-x7dq1sy4	393	5	in	in	IN
cord-259748-x7dq1sy4	393	6	the	the	DT
cord-259748-x7dq1sy4	393	7	endothelium	endothelium	NN
cord-259748-x7dq1sy4	393	8	within	within	IN
cord-259748-x7dq1sy4	393	9	the	the	DT
cord-259748-x7dq1sy4	393	10	tumor	tumor	NN
cord-259748-x7dq1sy4	393	11	microenvironment	microenvironment	NN
cord-259748-x7dq1sy4	393	12	(	(	-LRB-
cord-259748-x7dq1sy4	393	13	TME	TME	NNP
cord-259748-x7dq1sy4	393	14	)	)	-RRB-
cord-259748-x7dq1sy4	393	15	could	could	MD
cord-259748-x7dq1sy4	393	16	contribute	contribute	VB
cord-259748-x7dq1sy4	393	17	to	to	IN
cord-259748-x7dq1sy4	393	18	the	the	DT
cord-259748-x7dq1sy4	393	19	remodeling	remodeling	NN
cord-259748-x7dq1sy4	393	20	of	of	IN
cord-259748-x7dq1sy4	393	21	tumor	tumor	NN
cord-259748-x7dq1sy4	393	22	vasculatures	vasculature	NNS
cord-259748-x7dq1sy4	393	23	,	,	,
cord-259748-x7dq1sy4	393	24	and	and	CC
cord-259748-x7dq1sy4	393	25	may	may	MD
cord-259748-x7dq1sy4	393	26	have	have	VB
cord-259748-x7dq1sy4	393	27	positive	positive	JJ
cord-259748-x7dq1sy4	393	28	effects	effect	NNS
cord-259748-x7dq1sy4	393	29	on	on	IN
cord-259748-x7dq1sy4	393	30	tumor	tumor	NN
cord-259748-x7dq1sy4	393	31	regression	regression	NN
cord-259748-x7dq1sy4	393	32	(	(	-LRB-
cord-259748-x7dq1sy4	393	33	232	232	CD
cord-259748-x7dq1sy4	393	34	)	)	-RRB-
cord-259748-x7dq1sy4	393	35	.	.	.
cord-259748-x7dq1sy4	394	1	Dendritic	Dendritic	NNP
cord-259748-x7dq1sy4	394	2	Cells	cell	NNS
cord-259748-x7dq1sy4	394	3	are	be	VBP
cord-259748-x7dq1sy4	394	4	the	the	DT
cord-259748-x7dq1sy4	394	5	main	main	JJ
cord-259748-x7dq1sy4	394	6	source	source	NN
cord-259748-x7dq1sy4	394	7	of	of	IN
cord-259748-x7dq1sy4	394	8	type	type	NN
cord-259748-x7dq1sy4	394	9	-	-	:
cord-259748-x7dq1sy4	394	10	I	-PRON-	PRP
cord-259748-x7dq1sy4	394	11	IFN	IFN	NNP
cord-259748-x7dq1sy4	394	12	in	in	IN
cord-259748-x7dq1sy4	394	13	several	several	JJ
cord-259748-x7dq1sy4	394	14	types	type	NNS
cord-259748-x7dq1sy4	394	15	of	of	IN
cord-259748-x7dq1sy4	394	16	TMEs	tme	NNS
cord-259748-x7dq1sy4	394	17	and	and	CC
cord-259748-x7dq1sy4	394	18	are	be	VBP
cord-259748-x7dq1sy4	394	19	dependent	dependent	JJ
cord-259748-x7dq1sy4	394	20	on	on	IN
cord-259748-x7dq1sy4	394	21	STING	sting	NN
cord-259748-x7dq1sy4	394	22	signaling	signal	VBG
cord-259748-x7dq1sy4	394	23	(	(	-LRB-
cord-259748-x7dq1sy4	394	24	229	229	CD
cord-259748-x7dq1sy4	394	25	)	)	-RRB-
cord-259748-x7dq1sy4	394	26	.	.	.
cord-259748-x7dq1sy4	395	1	More	more	RBR
cord-259748-x7dq1sy4	395	2	preferentially	preferentially	RB
cord-259748-x7dq1sy4	395	3	than	than	IN
cord-259748-x7dq1sy4	395	4	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	395	5	,	,	,
cord-259748-x7dq1sy4	395	6	infiltrating	infiltrate	VBG
cord-259748-x7dq1sy4	395	7	DCs	dc	NNS
cord-259748-x7dq1sy4	395	8	take	take	VBP
cord-259748-x7dq1sy4	395	9	up	up	RP
cord-259748-x7dq1sy4	395	10	tumor	tumor	NN
cord-259748-x7dq1sy4	395	11	-	-	HYPH
cord-259748-x7dq1sy4	395	12	derived	derive	VBN
cord-259748-x7dq1sy4	395	13	DNA	dna	NN
cord-259748-x7dq1sy4	395	14	or	or	CC
cord-259748-x7dq1sy4	395	15	cGAMP	cgamp	NN
cord-259748-x7dq1sy4	395	16	from	from	IN
cord-259748-x7dq1sy4	395	17	dying	die	VBG
cord-259748-x7dq1sy4	395	18	cell	cell	NN
cord-259748-x7dq1sy4	395	19	fragments	fragment	NNS
cord-259748-x7dq1sy4	395	20	by	by	IN
cord-259748-x7dq1sy4	395	21	phagocytosis	phagocytosis	NN
cord-259748-x7dq1sy4	395	22	(	(	-LRB-
cord-259748-x7dq1sy4	395	23	27	27	CD
cord-259748-x7dq1sy4	395	24	,	,	,
cord-259748-x7dq1sy4	395	25	29	29	CD
cord-259748-x7dq1sy4	395	26	,	,	,
cord-259748-x7dq1sy4	395	27	129	129	CD
cord-259748-x7dq1sy4	395	28	,	,	,
cord-259748-x7dq1sy4	395	29	226	226	CD
cord-259748-x7dq1sy4	395	30	,	,	,
cord-259748-x7dq1sy4	395	31	233	233	CD
cord-259748-x7dq1sy4	395	32	)	)	-RRB-
cord-259748-x7dq1sy4	395	33	.	.	.
cord-259748-x7dq1sy4	396	1	Moreover	moreover	RB
cord-259748-x7dq1sy4	396	2	,	,	,
cord-259748-x7dq1sy4	396	3	cancer	cancer	NN
cord-259748-x7dq1sy4	396	4	cells	cell	NNS
cord-259748-x7dq1sy4	396	5	can	can	MD
cord-259748-x7dq1sy4	396	6	package	package	VB
cord-259748-x7dq1sy4	396	7	DNA	dna	NN
cord-259748-x7dq1sy4	396	8	into	into	IN
cord-259748-x7dq1sy4	396	9	exosomes	exosome	NNS
cord-259748-x7dq1sy4	396	10	and	and	CC
cord-259748-x7dq1sy4	396	11	transfer	transfer	VB
cord-259748-x7dq1sy4	396	12	DNA	dna	NN
cord-259748-x7dq1sy4	396	13	to	to	IN
cord-259748-x7dq1sy4	396	14	DCs	DCs	NNP
cord-259748-x7dq1sy4	396	15	(	(	-LRB-
cord-259748-x7dq1sy4	396	16	234	234	CD
cord-259748-x7dq1sy4	396	17	)	)	-RRB-
cord-259748-x7dq1sy4	396	18	.	.	.
cord-259748-x7dq1sy4	397	1	Produced	produce	VBN
cord-259748-x7dq1sy4	397	2	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	397	3	by	by	IN
cord-259748-x7dq1sy4	397	4	cancer	cancer	NN
cord-259748-x7dq1sy4	397	5	cells	cell	NNS
cord-259748-x7dq1sy4	397	6	can	can	MD
cord-259748-x7dq1sy4	397	7	also	also	RB
cord-259748-x7dq1sy4	397	8	be	be	VB
cord-259748-x7dq1sy4	397	9	transferred	transfer	VBN
cord-259748-x7dq1sy4	397	10	to	to	IN
cord-259748-x7dq1sy4	397	11	DCs	DCs	NNP
cord-259748-x7dq1sy4	397	12	through	through	IN
cord-259748-x7dq1sy4	397	13	forming	form	VBG
cord-259748-x7dq1sy4	397	14	gap	gap	NN
cord-259748-x7dq1sy4	397	15	junction	junction	NN
cord-259748-x7dq1sy4	397	16	(	(	-LRB-
cord-259748-x7dq1sy4	397	17	53	53	CD
cord-259748-x7dq1sy4	397	18	)	)	-RRB-
cord-259748-x7dq1sy4	397	19	.	.	.
cord-259748-x7dq1sy4	398	1	By	by	IN
cord-259748-x7dq1sy4	398	2	activating	activate	VBG
cord-259748-x7dq1sy4	398	3	cGAS	cgas	JJ
cord-259748-x7dq1sy4	398	4	-	-	HYPH
cord-259748-x7dq1sy4	398	5	STING	sting	NN
cord-259748-x7dq1sy4	398	6	signal	signal	NN
cord-259748-x7dq1sy4	398	7	in	in	IN
cord-259748-x7dq1sy4	398	8	DCs	DCs	NNP
cord-259748-x7dq1sy4	398	9	,	,	,
cord-259748-x7dq1sy4	398	10	CD8α	CD8α	NNP
cord-259748-x7dq1sy4	398	11	+	+	CC
cord-259748-x7dq1sy4	398	12	subtype	subtype	NN
cord-259748-x7dq1sy4	398	13	DCs	DCs	NNP
cord-259748-x7dq1sy4	398	14	secret	secret	JJ
cord-259748-x7dq1sy4	398	15	chemokines	chemokine	NNS
cord-259748-x7dq1sy4	398	16	such	such	JJ
cord-259748-x7dq1sy4	398	17	as	as	IN
cord-259748-x7dq1sy4	398	18	CCL5	CCL5	NNP
cord-259748-x7dq1sy4	398	19	and	and	CC
cord-259748-x7dq1sy4	398	20	CXCL10	CXCL10	NNP
cord-259748-x7dq1sy4	398	21	and	and	CC
cord-259748-x7dq1sy4	398	22	crossprime	crossprime	NN
cord-259748-x7dq1sy4	398	23	infiltrating	infiltrate	VBG
cord-259748-x7dq1sy4	398	24	anti	anti	JJ
cord-259748-x7dq1sy4	398	25	-	-	JJ
cord-259748-x7dq1sy4	398	26	tumor	tumor	JJ
cord-259748-x7dq1sy4	398	27	CD8	CD8	NNP
cord-259748-x7dq1sy4	398	28	+	+	CC
cord-259748-x7dq1sy4	398	29	T	T	NNP
cord-259748-x7dq1sy4	398	30	cells	cell	NNS
cord-259748-x7dq1sy4	398	31	(	(	-LRB-
cord-259748-x7dq1sy4	398	32	29	29	CD
cord-259748-x7dq1sy4	398	33	,	,	,
cord-259748-x7dq1sy4	398	34	226	226	CD
cord-259748-x7dq1sy4	398	35	,	,	,
cord-259748-x7dq1sy4	398	36	(	(	-LRB-
cord-259748-x7dq1sy4	398	37	235	235	CD
cord-259748-x7dq1sy4	398	38	)	)	-RRB-
cord-259748-x7dq1sy4	398	39	(	(	-LRB-
cord-259748-x7dq1sy4	398	40	236	236	CD
cord-259748-x7dq1sy4	398	41	)	)	-RRB-
cord-259748-x7dq1sy4	398	42	(	(	-LRB-
cord-259748-x7dq1sy4	398	43	237	237	CD
cord-259748-x7dq1sy4	398	44	)	)	-RRB-
cord-259748-x7dq1sy4	398	45	.	.	.
cord-259748-x7dq1sy4	399	1	In	in	IN
cord-259748-x7dq1sy4	399	2	contrast	contrast	NN
cord-259748-x7dq1sy4	399	3	,	,	,
cord-259748-x7dq1sy4	399	4	numbers	number	NNS
cord-259748-x7dq1sy4	399	5	of	of	IN
cord-259748-x7dq1sy4	399	6	immune	immune	NN
cord-259748-x7dq1sy4	399	7	-	-	HYPH
cord-259748-x7dq1sy4	399	8	suppressing	suppress	VBG
cord-259748-x7dq1sy4	399	9	cells	cell	NNS
cord-259748-x7dq1sy4	399	10	such	such	JJ
cord-259748-x7dq1sy4	399	11	as	as	IN
cord-259748-x7dq1sy4	399	12	T	T	NNP
cord-259748-x7dq1sy4	399	13	reg	reg	NN
cord-259748-x7dq1sy4	399	14	cells	cell	NNS
cord-259748-x7dq1sy4	399	15	,	,	,
cord-259748-x7dq1sy4	399	16	myeloid	myeloid	NN
cord-259748-x7dq1sy4	399	17	-	-	HYPH
cord-259748-x7dq1sy4	399	18	derived	derive	VBN
cord-259748-x7dq1sy4	399	19	suppressor	suppressor	NN
cord-259748-x7dq1sy4	399	20	monocytes	monocyte	NNS
cord-259748-x7dq1sy4	399	21	and	and	CC
cord-259748-x7dq1sy4	399	22	M2	m2	JJ
cord-259748-x7dq1sy4	399	23	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	399	24	have	have	VBP
cord-259748-x7dq1sy4	399	25	been	be	VBN
cord-259748-x7dq1sy4	399	26	reported	report	VBN
cord-259748-x7dq1sy4	399	27	to	to	TO
cord-259748-x7dq1sy4	399	28	be	be	VB
cord-259748-x7dq1sy4	399	29	decreased	decrease	VBN
cord-259748-x7dq1sy4	399	30	(	(	-LRB-
cord-259748-x7dq1sy4	399	31	225	225	CD
cord-259748-x7dq1sy4	399	32	,	,	,
cord-259748-x7dq1sy4	399	33	238	238	CD
cord-259748-x7dq1sy4	399	34	,	,	,
cord-259748-x7dq1sy4	399	35	239	239	CD
cord-259748-x7dq1sy4	399	36	)	)	-RRB-
cord-259748-x7dq1sy4	399	37	.	.	.
cord-259748-x7dq1sy4	400	1	Expression	expression	NN
cord-259748-x7dq1sy4	400	2	of	of	IN
cord-259748-x7dq1sy4	400	3	IL-15	IL-15	NNP
cord-259748-x7dq1sy4	400	4	/	/	SYM
cord-259748-x7dq1sy4	400	5	IL-15Rα	IL-15Rα	NNP
cord-259748-x7dq1sy4	400	6	complex	complex	JJ
cord-259748-x7dq1sy4	400	7	is	be	VBZ
cord-259748-x7dq1sy4	400	8	up	up	RB
cord-259748-x7dq1sy4	400	9	-	-	HYPH
cord-259748-x7dq1sy4	400	10	regulated	regulate	VBN
cord-259748-x7dq1sy4	400	11	in	in	IN
cord-259748-x7dq1sy4	400	12	myeloid	myeloid	JJ
cord-259748-x7dq1sy4	400	13	cells	cell	NNS
cord-259748-x7dq1sy4	400	14	with	with	IN
cord-259748-x7dq1sy4	400	15	the	the	DT
cord-259748-x7dq1sy4	400	16	help	help	NN
cord-259748-x7dq1sy4	400	17	of	of	IN
cord-259748-x7dq1sy4	400	18	STING	sting	NN
cord-259748-x7dq1sy4	400	19	/	/	SYM
cord-259748-x7dq1sy4	400	20	type	type	NN
cord-259748-x7dq1sy4	401	1	-I	-I	NFP
cord-259748-x7dq1sy4	401	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	401	3	and	and	CC
cord-259748-x7dq1sy4	401	4	promotes	promote	VBZ
cord-259748-x7dq1sy4	401	5	tumor	tumor	NN
cord-259748-x7dq1sy4	401	6	regression	regression	NN
cord-259748-x7dq1sy4	401	7	(	(	-LRB-
cord-259748-x7dq1sy4	401	8	240	240	CD
cord-259748-x7dq1sy4	401	9	)	)	-RRB-
cord-259748-x7dq1sy4	401	10	.	.	.
cord-259748-x7dq1sy4	402	1	Tumor	tumor	NN
cord-259748-x7dq1sy4	402	2	cells	cell	NNS
cord-259748-x7dq1sy4	402	3	can	can	MD
cord-259748-x7dq1sy4	402	4	evade	evade	VB
cord-259748-x7dq1sy4	402	5	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	402	6	cellular	cellular	JJ
cord-259748-x7dq1sy4	402	7	surveillance	surveillance	NN
cord-259748-x7dq1sy4	402	8	in	in	IN
cord-259748-x7dq1sy4	402	9	different	different	JJ
cord-259748-x7dq1sy4	402	10	ways	way	NNS
cord-259748-x7dq1sy4	402	11	.	.	.
cord-259748-x7dq1sy4	403	1	In	in	IN
cord-259748-x7dq1sy4	403	2	various	various	JJ
cord-259748-x7dq1sy4	403	3	cancer	cancer	NN
cord-259748-x7dq1sy4	403	4	cell	cell	NN
cord-259748-x7dq1sy4	403	5	lines	line	NNS
cord-259748-x7dq1sy4	403	6	,	,	,
cord-259748-x7dq1sy4	403	7	cGAS	cgas	NN
cord-259748-x7dq1sy4	403	8	,	,	,
cord-259748-x7dq1sy4	403	9	STING	STING	NNP
cord-259748-x7dq1sy4	403	10	,	,	,
cord-259748-x7dq1sy4	403	11	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	403	12	,	,	,
cord-259748-x7dq1sy4	403	13	and	and	CC
cord-259748-x7dq1sy4	403	14	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	403	15	are	be	VBP
cord-259748-x7dq1sy4	403	16	mutated	mutate	VBN
cord-259748-x7dq1sy4	403	17	frequently	frequently	RB
cord-259748-x7dq1sy4	403	18	and	and	CC
cord-259748-x7dq1sy4	403	19	their	-PRON-	PRP$
cord-259748-x7dq1sy4	403	20	decreased	decrease	VBN
cord-259748-x7dq1sy4	403	21	expressions	expression	NNS
cord-259748-x7dq1sy4	403	22	are	be	VBP
cord-259748-x7dq1sy4	403	23	also	also	RB
cord-259748-x7dq1sy4	403	24	related	relate	VBN
cord-259748-x7dq1sy4	403	25	to	to	IN
cord-259748-x7dq1sy4	403	26	the	the	DT
cord-259748-x7dq1sy4	403	27	high	high	JJ
cord-259748-x7dq1sy4	403	28	level	level	NN
cord-259748-x7dq1sy4	403	29	of	of	IN
cord-259748-x7dq1sy4	403	30	methylation	methylation	NN
cord-259748-x7dq1sy4	403	31	(	(	-LRB-
cord-259748-x7dq1sy4	403	32	241	241	CD
cord-259748-x7dq1sy4	403	33	)	)	-RRB-
cord-259748-x7dq1sy4	403	34	.	.	.
cord-259748-x7dq1sy4	404	1	STING	sting	NN
cord-259748-x7dq1sy4	404	2	expression	expression	NN
cord-259748-x7dq1sy4	404	3	has	have	VBZ
cord-259748-x7dq1sy4	404	4	been	be	VBN
cord-259748-x7dq1sy4	404	5	shown	show	VBN
cord-259748-x7dq1sy4	404	6	to	to	TO
cord-259748-x7dq1sy4	404	7	be	be	VB
cord-259748-x7dq1sy4	404	8	suppressed	suppress	VBN
cord-259748-x7dq1sy4	404	9	by	by	IN
cord-259748-x7dq1sy4	404	10	the	the	DT
cord-259748-x7dq1sy4	404	11	alternative	alternative	NN
cord-259748-x7dq1sy4	404	12	lengthening	lengthening	NN
cord-259748-x7dq1sy4	404	13	of	of	IN
cord-259748-x7dq1sy4	404	14	telomeres	telomere	NNS
cord-259748-x7dq1sy4	404	15	(	(	-LRB-
cord-259748-x7dq1sy4	404	16	ALT	ALT	NNP
cord-259748-x7dq1sy4	404	17	)	)	-RRB-
cord-259748-x7dq1sy4	404	18	pathway	pathway	NN
cord-259748-x7dq1sy4	404	19	,	,	,
cord-259748-x7dq1sy4	404	20	which	which	WDT
cord-259748-x7dq1sy4	404	21	is	be	VBZ
cord-259748-x7dq1sy4	404	22	responsible	responsible	JJ
cord-259748-x7dq1sy4	404	23	for	for	IN
cord-259748-x7dq1sy4	404	24	prolonging	prolong	VBG
cord-259748-x7dq1sy4	404	25	the	the	DT
cord-259748-x7dq1sy4	404	26	telomere	telomere	NN
cord-259748-x7dq1sy4	404	27	length	length	NN
cord-259748-x7dq1sy4	404	28	and	and	CC
cord-259748-x7dq1sy4	404	29	maintaining	maintain	VBG
cord-259748-x7dq1sy4	404	30	the	the	DT
cord-259748-x7dq1sy4	404	31	proliferation	proliferation	NN
cord-259748-x7dq1sy4	404	32	of	of	IN
cord-259748-x7dq1sy4	404	33	tumor	tumor	NN
cord-259748-x7dq1sy4	404	34	cells	cell	NNS
cord-259748-x7dq1sy4	404	35	(	(	-LRB-
cord-259748-x7dq1sy4	404	36	242	242	CD
cord-259748-x7dq1sy4	404	37	)	)	-RRB-
cord-259748-x7dq1sy4	404	38	.	.	.
cord-259748-x7dq1sy4	405	1	A	a	DT
cord-259748-x7dq1sy4	405	2	hypoxic	hypoxic	JJ
cord-259748-x7dq1sy4	405	3	environment	environment	NN
cord-259748-x7dq1sy4	405	4	in	in	IN
cord-259748-x7dq1sy4	405	5	tumor	tumor	NN
cord-259748-x7dq1sy4	405	6	cells	cell	NNS
cord-259748-x7dq1sy4	405	7	can	can	MD
cord-259748-x7dq1sy4	405	8	lead	lead	VB
cord-259748-x7dq1sy4	405	9	to	to	IN
cord-259748-x7dq1sy4	405	10	accumulation	accumulation	NN
cord-259748-x7dq1sy4	405	11	of	of	IN
cord-259748-x7dq1sy4	405	12	lactic	lactic	JJ
cord-259748-x7dq1sy4	405	13	acid	acid	NN
cord-259748-x7dq1sy4	405	14	and	and	CC
cord-259748-x7dq1sy4	405	15	is	be	VBZ
cord-259748-x7dq1sy4	405	16	associated	associate	VBN
cord-259748-x7dq1sy4	405	17	with	with	IN
cord-259748-x7dq1sy4	405	18	the	the	DT
cord-259748-x7dq1sy4	405	19	inhibition	inhibition	NN
cord-259748-x7dq1sy4	405	20	of	of	IN
cord-259748-x7dq1sy4	405	21	tumor	tumor	NN
cord-259748-x7dq1sy4	405	22	-	-	HYPH
cord-259748-x7dq1sy4	405	23	conditional	conditional	JJ
cord-259748-x7dq1sy4	405	24	DCs	dc	NNS
cord-259748-x7dq1sy4	405	25	and	and	CC
cord-259748-x7dq1sy4	405	26	reduced	reduced	JJ
cord-259748-x7dq1sy4	405	27	expression	expression	NN
cord-259748-x7dq1sy4	405	28	of	of	IN
cord-259748-x7dq1sy4	405	29	IFN	IFN	NNP
cord-259748-x7dq1sy4	405	30	signaling	signal	VBG
cord-259748-x7dq1sy4	405	31	molecules	molecule	NNS
cord-259748-x7dq1sy4	405	32	(	(	-LRB-
cord-259748-x7dq1sy4	405	33	243	243	CD
cord-259748-x7dq1sy4	405	34	)	)	-RRB-
cord-259748-x7dq1sy4	405	35	.	.	.
cord-259748-x7dq1sy4	406	1	In	in	IN
cord-259748-x7dq1sy4	406	2	breast	breast	NN
cord-259748-x7dq1sy4	406	3	cancer	cancer	NN
cord-259748-x7dq1sy4	406	4	,	,	,
cord-259748-x7dq1sy4	406	5	functional	functional	JJ
cord-259748-x7dq1sy4	406	6	up	up	NN
cord-259748-x7dq1sy4	406	7	-	-	HYPH
cord-259748-x7dq1sy4	406	8	regulation	regulation	NN
cord-259748-x7dq1sy4	406	9	of	of	IN
cord-259748-x7dq1sy4	406	10	expression	expression	NN
cord-259748-x7dq1sy4	406	11	of	of	IN
cord-259748-x7dq1sy4	406	12	human	human	JJ
cord-259748-x7dq1sy4	406	13	epidermal	epidermal	JJ
cord-259748-x7dq1sy4	406	14	growth	growth	NN
cord-259748-x7dq1sy4	406	15	factor	factor	NN
cord-259748-x7dq1sy4	406	16	receptor	receptor	NN
cord-259748-x7dq1sy4	406	17	2	2	CD
cord-259748-x7dq1sy4	406	18	(	(	-LRB-
cord-259748-x7dq1sy4	406	19	HER2	HER2	NNP
cord-259748-x7dq1sy4	406	20	)	)	-RRB-
cord-259748-x7dq1sy4	406	21	,	,	,
cord-259748-x7dq1sy4	406	22	a	a	DT
cord-259748-x7dq1sy4	406	23	ligand	ligand	NN
cord-259748-x7dq1sy4	406	24	-	-	HYPH
cord-259748-x7dq1sy4	406	25	independent	independent	JJ
cord-259748-x7dq1sy4	406	26	receptor	receptor	NN
cord-259748-x7dq1sy4	406	27	tyrosine	tyrosine	NN
cord-259748-x7dq1sy4	406	28	kinase	kinase	NN
cord-259748-x7dq1sy4	406	29	(	(	-LRB-
cord-259748-x7dq1sy4	406	30	RTK	RTK	NNP
cord-259748-x7dq1sy4	406	31	)	)	-RRB-
cord-259748-x7dq1sy4	406	32	,	,	,
cord-259748-x7dq1sy4	406	33	can	can	MD
cord-259748-x7dq1sy4	406	34	arrest	arrest	VB
cord-259748-x7dq1sy4	406	35	the	the	DT
cord-259748-x7dq1sy4	406	36	expression	expression	NN
cord-259748-x7dq1sy4	406	37	of	of	IN
cord-259748-x7dq1sy4	406	38	RAC	RAC	NNP
cord-259748-x7dq1sy4	406	39	-	-	HYPH
cord-259748-x7dq1sy4	406	40	alpha	alpha	NN
cord-259748-x7dq1sy4	406	41	serine	serine	NN
cord-259748-x7dq1sy4	406	42	/	/	SYM
cord-259748-x7dq1sy4	406	43	threonineprotein	threonineprotein	NNP
cord-259748-x7dq1sy4	406	44	kinase	kinase	NNP
cord-259748-x7dq1sy4	406	45	(	(	-LRB-
cord-259748-x7dq1sy4	406	46	AKT1	AKT1	NNP
cord-259748-x7dq1sy4	406	47	)	)	-RRB-
cord-259748-x7dq1sy4	406	48	(	(	-LRB-
cord-259748-x7dq1sy4	406	49	a	a	DT
cord-259748-x7dq1sy4	406	50	key	key	JJ
cord-259748-x7dq1sy4	406	51	factor	factor	NN
cord-259748-x7dq1sy4	406	52	in	in	IN
cord-259748-x7dq1sy4	406	53	the	the	DT
cord-259748-x7dq1sy4	406	54	mTOR	mTOR	NNP
cord-259748-x7dq1sy4	406	55	pathway	pathway	NNP
cord-259748-x7dq1sy4	406	56	)	)	-RRB-
cord-259748-x7dq1sy4	406	57	,	,	,
cord-259748-x7dq1sy4	406	58	which	which	WDT
cord-259748-x7dq1sy4	406	59	is	be	VBZ
cord-259748-x7dq1sy4	406	60	reported	report	VBN
cord-259748-x7dq1sy4	406	61	to	to	TO
cord-259748-x7dq1sy4	406	62	inhibit	inhibit	VB
cord-259748-x7dq1sy4	406	63	the	the	DT
cord-259748-x7dq1sy4	406	64	activation	activation	NN
cord-259748-x7dq1sy4	406	65	of	of	IN
cord-259748-x7dq1sy4	406	66	cGAS	cgas	NN
cord-259748-x7dq1sy4	406	67	and	and	CC
cord-259748-x7dq1sy4	406	68	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	406	69	(	(	-LRB-
cord-259748-x7dq1sy4	406	70	244	244	CD
cord-259748-x7dq1sy4	406	71	,	,	,
cord-259748-x7dq1sy4	406	72	245	245	CD
cord-259748-x7dq1sy4	406	73	)	)	-RRB-
cord-259748-x7dq1sy4	406	74	.	.	.
cord-259748-x7dq1sy4	407	1	Patients	patient	NNS
cord-259748-x7dq1sy4	407	2	with	with	IN
cord-259748-x7dq1sy4	407	3	lung	lung	NN
cord-259748-x7dq1sy4	407	4	adenocarcinoma	adenocarcinoma	NN
cord-259748-x7dq1sy4	407	5	have	have	VBP
cord-259748-x7dq1sy4	407	6	a	a	DT
cord-259748-x7dq1sy4	407	7	low	low	JJ
cord-259748-x7dq1sy4	407	8	probability	probability	NN
cord-259748-x7dq1sy4	407	9	of	of	IN
cord-259748-x7dq1sy4	407	10	survival	survival	NN
cord-259748-x7dq1sy4	407	11	if	if	IN
cord-259748-x7dq1sy4	407	12	they	-PRON-	PRP
cord-259748-x7dq1sy4	407	13	have	have	VBP
cord-259748-x7dq1sy4	407	14	reduced	reduce	VBN
cord-259748-x7dq1sy4	407	15	expression	expression	NN
cord-259748-x7dq1sy4	407	16	of	of	IN
cord-259748-x7dq1sy4	407	17	cGAS	cgas	JJ
cord-259748-x7dq1sy4	407	18	(	(	-LRB-
cord-259748-x7dq1sy4	407	19	132	132	CD
cord-259748-x7dq1sy4	407	20	)	)	-RRB-
cord-259748-x7dq1sy4	407	21	.	.	.
cord-259748-x7dq1sy4	408	1	Thus	thus	RB
cord-259748-x7dq1sy4	408	2	,	,	,
cord-259748-x7dq1sy4	408	3	expression	expression	NN
cord-259748-x7dq1sy4	408	4	of	of	IN
cord-259748-x7dq1sy4	408	5	the	the	DT
cord-259748-x7dq1sy4	408	6	cGAS	cgas	NN
cord-259748-x7dq1sy4	408	7	-	-	HYPH
cord-259748-x7dq1sy4	408	8	STING	sting	NN
cord-259748-x7dq1sy4	408	9	and	and	CC
cord-259748-x7dq1sy4	408	10	DNA	dna	NN
cord-259748-x7dq1sy4	408	11	-	-	HYPH
cord-259748-x7dq1sy4	408	12	damage	damage	NN
cord-259748-x7dq1sy4	408	13	marker	marker	NN
cord-259748-x7dq1sy4	408	14	histone	histone	NN
cord-259748-x7dq1sy4	408	15	γH2AX	γH2AX	NNP
cord-259748-x7dq1sy4	408	16	in	in	IN
cord-259748-x7dq1sy4	408	17	tumor	tumor	NN
cord-259748-x7dq1sy4	408	18	cells	cell	NNS
cord-259748-x7dq1sy4	408	19	could	could	MD
cord-259748-x7dq1sy4	408	20	be	be	VB
cord-259748-x7dq1sy4	408	21	considered	consider	VBN
cord-259748-x7dq1sy4	408	22	as	as	IN
cord-259748-x7dq1sy4	408	23	independent	independent	JJ
cord-259748-x7dq1sy4	408	24	prognostic	prognostic	JJ
cord-259748-x7dq1sy4	408	25	factors	factor	NNS
cord-259748-x7dq1sy4	408	26	to	to	TO
cord-259748-x7dq1sy4	408	27	predict	predict	VB
cord-259748-x7dq1sy4	408	28	therapy	therapy	NN
cord-259748-x7dq1sy4	408	29	response	response	NN
cord-259748-x7dq1sy4	408	30	and	and	CC
cord-259748-x7dq1sy4	408	31	clinical	clinical	JJ
cord-259748-x7dq1sy4	408	32	outcome	outcome	NN
cord-259748-x7dq1sy4	408	33	,	,	,
cord-259748-x7dq1sy4	408	34	and	and	CC
cord-259748-x7dq1sy4	408	35	could	could	MD
cord-259748-x7dq1sy4	408	36	be	be	VB
cord-259748-x7dq1sy4	408	37	superior	superior	JJ
cord-259748-x7dq1sy4	408	38	to	to	IN
cord-259748-x7dq1sy4	408	39	that	that	DT
cord-259748-x7dq1sy4	408	40	of	of	IN
cord-259748-x7dq1sy4	408	41	traditional	traditional	JJ
cord-259748-x7dq1sy4	408	42	markers	marker	NNS
cord-259748-x7dq1sy4	408	43	like	like	IN
cord-259748-x7dq1sy4	408	44	immunogenic	immunogenic	JJ
cord-259748-x7dq1sy4	408	45	cell	cell	NN
cord-259748-x7dq1sy4	408	46	death	death	NN
cord-259748-x7dq1sy4	408	47	and	and	CC
cord-259748-x7dq1sy4	408	48	T	t	NN
cord-259748-x7dq1sy4	408	49	cells	cell	NNS
cord-259748-x7dq1sy4	408	50	number	number	NN
cord-259748-x7dq1sy4	408	51	(	(	-LRB-
cord-259748-x7dq1sy4	408	52	246	246	CD
cord-259748-x7dq1sy4	408	53	)	)	-RRB-
cord-259748-x7dq1sy4	408	54	.	.	.
cord-259748-x7dq1sy4	409	1	However	however	RB
cord-259748-x7dq1sy4	409	2	,	,	,
cord-259748-x7dq1sy4	409	3	some	some	DT
cord-259748-x7dq1sy4	409	4	scholars	scholar	NNS
cord-259748-x7dq1sy4	409	5	have	have	VBP
cord-259748-x7dq1sy4	409	6	arrived	arrive	VBN
cord-259748-x7dq1sy4	409	7	at	at	IN
cord-259748-x7dq1sy4	409	8	opposite	opposite	JJ
cord-259748-x7dq1sy4	409	9	conclusions	conclusion	NNS
cord-259748-x7dq1sy4	409	10	.	.	.
cord-259748-x7dq1sy4	410	1	When	when	WRB
cord-259748-x7dq1sy4	410	2	DSBs	dsb	NNS
cord-259748-x7dq1sy4	410	3	occur	occur	VBP
cord-259748-x7dq1sy4	410	4	in	in	IN
cord-259748-x7dq1sy4	410	5	cancer	cancer	NN
cord-259748-x7dq1sy4	410	6	cells	cell	NNS
cord-259748-x7dq1sy4	410	7	,	,	,
cord-259748-x7dq1sy4	410	8	cGAS	cgas	NN
cord-259748-x7dq1sy4	410	9	can	can	MD
cord-259748-x7dq1sy4	410	10	be	be	VB
cord-259748-x7dq1sy4	410	11	relocated	relocate	VBN
cord-259748-x7dq1sy4	410	12	to	to	IN
cord-259748-x7dq1sy4	410	13	the	the	DT
cord-259748-x7dq1sy4	410	14	nucleus	nucleus	NN
cord-259748-x7dq1sy4	410	15	and	and	CC
cord-259748-x7dq1sy4	410	16	obstruct	obstruct	VB
cord-259748-x7dq1sy4	410	17	the	the	DT
cord-259748-x7dq1sy4	410	18	formation	formation	NN
cord-259748-x7dq1sy4	410	19	of	of	IN
cord-259748-x7dq1sy4	410	20	the	the	DT
cord-259748-x7dq1sy4	410	21	PARP1-Timeless	PARP1-Timeless	NNP
cord-259748-x7dq1sy4	410	22	complex	complex	NN
cord-259748-x7dq1sy4	410	23	,	,	,
cord-259748-x7dq1sy4	410	24	thereby	thereby	RB
cord-259748-x7dq1sy4	410	25	inhibiting	inhibit	VBG
cord-259748-x7dq1sy4	410	26	homologous	homologous	JJ
cord-259748-x7dq1sy4	410	27	recombination	recombination	NN
cord-259748-x7dq1sy4	410	28	repair	repair	NN
cord-259748-x7dq1sy4	410	29	and	and	CC
cord-259748-x7dq1sy4	410	30	maintaining	maintain	VBG
cord-259748-x7dq1sy4	410	31	CIN	CIN	NNP
cord-259748-x7dq1sy4	410	32	,	,	,
cord-259748-x7dq1sy4	410	33	which	which	WDT
cord-259748-x7dq1sy4	410	34	potentiates	potentiate	VBZ
cord-259748-x7dq1sy4	410	35	tumor	tumor	NN
cord-259748-x7dq1sy4	410	36	evolution	evolution	NN
cord-259748-x7dq1sy4	410	37	(	(	-LRB-
cord-259748-x7dq1sy4	410	38	35	35	CD
cord-259748-x7dq1sy4	410	39	,	,	,
cord-259748-x7dq1sy4	410	40	223	223	CD
cord-259748-x7dq1sy4	410	41	)	)	-RRB-
cord-259748-x7dq1sy4	410	42	.	.	.
cord-259748-x7dq1sy4	411	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	411	2	has	have	VBZ
cord-259748-x7dq1sy4	411	3	also	also	RB
cord-259748-x7dq1sy4	411	4	been	be	VBN
cord-259748-x7dq1sy4	411	5	reported	report	VBN
cord-259748-x7dq1sy4	411	6	that	that	IN
cord-259748-x7dq1sy4	411	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	411	8	recognizing	recognize	VBG
cord-259748-x7dq1sy4	411	9	CIN	CIN	NNP
cord-259748-x7dq1sy4	411	10	activates	activate	VBZ
cord-259748-x7dq1sy4	411	11	non	non	JJ
cord-259748-x7dq1sy4	411	12	-	-	JJ
cord-259748-x7dq1sy4	411	13	canonical	canonical	JJ
cord-259748-x7dq1sy4	411	14	NF	nf	NN
cord-259748-x7dq1sy4	411	15	-	-	HYPH
cord-259748-x7dq1sy4	411	16	κB	κB	NNP
cord-259748-x7dq1sy4	411	17	signaling	signal	VBG
cord-259748-x7dq1sy4	411	18	and	and	CC
cord-259748-x7dq1sy4	411	19	potentiates	potentiate	VBZ
cord-259748-x7dq1sy4	411	20	cellular	cellular	JJ
cord-259748-x7dq1sy4	411	21	metastasis	metastasis	NN
cord-259748-x7dq1sy4	411	22	programs	program	NNS
cord-259748-x7dq1sy4	411	23	(	(	-LRB-
cord-259748-x7dq1sy4	411	24	247	247	CD
cord-259748-x7dq1sy4	411	25	)	)	-RRB-
cord-259748-x7dq1sy4	411	26	.	.	.
cord-259748-x7dq1sy4	412	1	Furthermore	furthermore	RB
cord-259748-x7dq1sy4	412	2	,	,	,
cord-259748-x7dq1sy4	412	3	STING	sting	NN
cord-259748-x7dq1sy4	412	4	−/−	−/−	NNP
cord-259748-x7dq1sy4	412	5	mice	mouse	NNS
cord-259748-x7dq1sy4	412	6	are	be	VBP
cord-259748-x7dq1sy4	412	7	resistant	resistant	JJ
cord-259748-x7dq1sy4	412	8	to	to	IN
cord-259748-x7dq1sy4	412	9	skin	skin	NN
cord-259748-x7dq1sy4	412	10	carcinogenesis	carcinogenesis	NN
cord-259748-x7dq1sy4	412	11	in	in	IN
cord-259748-x7dq1sy4	412	12	a	a	DT
cord-259748-x7dq1sy4	412	13	7,12-dimethylbenz(a)anthracene	7,12-dimethylbenz(a)anthracene	CD
cord-259748-x7dq1sy4	412	14	(	(	-LRB-
cord-259748-x7dq1sy4	412	15	DMBA)-treatment	dmba)-treatment	CD
cord-259748-x7dq1sy4	412	16	model	model	NN
cord-259748-x7dq1sy4	412	17	.	.	.
cord-259748-x7dq1sy4	413	1	It	-PRON-	PRP
cord-259748-x7dq1sy4	413	2	has	have	VBZ
cord-259748-x7dq1sy4	413	3	been	be	VBN
cord-259748-x7dq1sy4	413	4	demonstrated	demonstrate	VBN
cord-259748-x7dq1sy4	413	5	that	that	IN
cord-259748-x7dq1sy4	413	6	when	when	WRB
cord-259748-x7dq1sy4	413	7	DMBA	DMBA	NNP
cord-259748-x7dq1sy4	413	8	-	-	HYPH
cord-259748-x7dq1sy4	413	9	induced	induce	VBN
cord-259748-x7dq1sy4	413	10	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	413	11	DNA	dna	NN
cord-259748-x7dq1sy4	413	12	leaks	leak	NNS
cord-259748-x7dq1sy4	413	13	into	into	IN
cord-259748-x7dq1sy4	413	14	the	the	DT
cord-259748-x7dq1sy4	413	15	cytoplasm	cytoplasm	NN
cord-259748-x7dq1sy4	413	16	,	,	,
cord-259748-x7dq1sy4	413	17	STING	STING	NNP
cord-259748-x7dq1sy4	413	18	can	can	MD
cord-259748-x7dq1sy4	413	19	induce	induce	VB
cord-259748-x7dq1sy4	413	20	chronic	chronic	JJ
cord-259748-x7dq1sy4	413	21	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	413	22	stimulation	stimulation	NN
cord-259748-x7dq1sy4	413	23	that	that	WDT
cord-259748-x7dq1sy4	413	24	contributes	contribute	VBZ
cord-259748-x7dq1sy4	413	25	to	to	IN
cord-259748-x7dq1sy4	413	26	cancer	cancer	NN
cord-259748-x7dq1sy4	413	27	development	development	NN
cord-259748-x7dq1sy4	413	28	(	(	-LRB-
cord-259748-x7dq1sy4	413	29	248	248	CD
cord-259748-x7dq1sy4	413	30	)	)	-RRB-
cord-259748-x7dq1sy4	413	31	.	.	.
cord-259748-x7dq1sy4	414	1	During	during	IN
cord-259748-x7dq1sy4	414	2	brain	brain	NN
cord-259748-x7dq1sy4	414	3	metastasis	metastasis	NN
cord-259748-x7dq1sy4	414	4	,	,	,
cord-259748-x7dq1sy4	414	5	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	414	6	transferred	transfer	VBN
cord-259748-x7dq1sy4	414	7	to	to	IN
cord-259748-x7dq1sy4	414	8	bystander	bystander	NN
cord-259748-x7dq1sy4	414	9	cells	cell	NNS
cord-259748-x7dq1sy4	414	10	(	(	-LRB-
cord-259748-x7dq1sy4	414	11	e.g.	e.g.	RB
cord-259748-x7dq1sy4	414	12	,	,	,
cord-259748-x7dq1sy4	414	13	astrocytes	astrocyte	NNS
cord-259748-x7dq1sy4	414	14	)	)	-RRB-
cord-259748-x7dq1sy4	414	15	can	can	MD
cord-259748-x7dq1sy4	414	16	also	also	RB
cord-259748-x7dq1sy4	414	17	produce	produce	VB
cord-259748-x7dq1sy4	414	18	IFNα	IFNα	NNS
cord-259748-x7dq1sy4	414	19	and	and	CC
cord-259748-x7dq1sy4	414	20	TNFα	TNFα	NNS
cord-259748-x7dq1sy4	414	21	in	in	IN
cord-259748-x7dq1sy4	414	22	the	the	DT
cord-259748-x7dq1sy4	414	23	TME	TME	NNP
cord-259748-x7dq1sy4	415	1	but	but	CC
cord-259748-x7dq1sy4	415	2	,	,	,
cord-259748-x7dq1sy4	415	3	in	in	IN
cord-259748-x7dq1sy4	415	4	this	this	DT
cord-259748-x7dq1sy4	415	5	context	context	NN
cord-259748-x7dq1sy4	415	6	,	,	,
cord-259748-x7dq1sy4	415	7	it	-PRON-	PRP
cord-259748-x7dq1sy4	415	8	will	will	MD
cord-259748-x7dq1sy4	415	9	support	support	VB
cord-259748-x7dq1sy4	415	10	tumor	tumor	NN
cord-259748-x7dq1sy4	415	11	development	development	NN
cord-259748-x7dq1sy4	415	12	and	and	CC
cord-259748-x7dq1sy4	415	13	chemoresistance	chemoresistance	NN
cord-259748-x7dq1sy4	415	14	(	(	-LRB-
cord-259748-x7dq1sy4	415	15	249	249	CD
cord-259748-x7dq1sy4	415	16	)	)	-RRB-
cord-259748-x7dq1sy4	415	17	.	.	.
cord-259748-x7dq1sy4	416	1	Coordinating	coordinate	VBG
cord-259748-x7dq1sy4	416	2	with	with	IN
cord-259748-x7dq1sy4	416	3	myeloid	myeloid	NN
cord-259748-x7dq1sy4	416	4	cells	cell	NNS
cord-259748-x7dq1sy4	416	5	penetrating	penetrate	VBG
cord-259748-x7dq1sy4	416	6	into	into	IN
cord-259748-x7dq1sy4	416	7	the	the	DT
cord-259748-x7dq1sy4	416	8	tumor	tumor	NN
cord-259748-x7dq1sy4	416	9	,	,	,
cord-259748-x7dq1sy4	416	10	myeloidderived	myeloidderived	JJ
cord-259748-x7dq1sy4	416	11	suppressor	suppressor	NN
cord-259748-x7dq1sy4	416	12	cells	cell	NNS
cord-259748-x7dq1sy4	416	13	can	can	MD
cord-259748-x7dq1sy4	416	14	also	also	RB
cord-259748-x7dq1sy4	416	15	be	be	VB
cord-259748-x7dq1sy4	416	16	recruited	recruit	VBN
cord-259748-x7dq1sy4	416	17	through	through	IN
cord-259748-x7dq1sy4	416	18	the	the	DT
cord-259748-x7dq1sy4	416	19	C	C	NNP
cord-259748-x7dq1sy4	416	20	-	-	HYPH
cord-259748-x7dq1sy4	416	21	C	C	NNP
cord-259748-x7dq1sy4	416	22	chemokine	chemokine	NN
cord-259748-x7dq1sy4	416	23	receptor	receptor	NN
cord-259748-x7dq1sy4	416	24	type	type	NN
cord-259748-x7dq1sy4	416	25	2	2	CD
cord-259748-x7dq1sy4	416	26	(	(	-LRB-
cord-259748-x7dq1sy4	416	27	CCR2	CCR2	NNP
cord-259748-x7dq1sy4	416	28	)	)	-RRB-
cord-259748-x7dq1sy4	416	29	(	(	-LRB-
cord-259748-x7dq1sy4	416	30	250	250	CD
cord-259748-x7dq1sy4	416	31	)	)	-RRB-
cord-259748-x7dq1sy4	416	32	.	.	.
cord-259748-x7dq1sy4	417	1	Another	another	DT
cord-259748-x7dq1sy4	417	2	study	study	NN
cord-259748-x7dq1sy4	417	3	found	find	VBD
cord-259748-x7dq1sy4	417	4	that	that	IN
cord-259748-x7dq1sy4	417	5	microparticles	microparticle	NNS
cord-259748-x7dq1sy4	417	6	yielded	yield	VBN
cord-259748-x7dq1sy4	417	7	by	by	IN
cord-259748-x7dq1sy4	417	8	tumor	tumor	NN
cord-259748-x7dq1sy4	417	9	cells	cell	NNS
cord-259748-x7dq1sy4	417	10	can	can	MD
cord-259748-x7dq1sy4	417	11	turn	turn	VB
cord-259748-x7dq1sy4	417	12	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	417	13	into	into	IN
cord-259748-x7dq1sy4	417	14	the	the	DT
cord-259748-x7dq1sy4	417	15	M2	m2	JJ
cord-259748-x7dq1sy4	417	16	type	type	NN
cord-259748-x7dq1sy4	417	17	through	through	IN
cord-259748-x7dq1sy4	417	18	cGAS	cgas	JJ
cord-259748-x7dq1sy4	417	19	-	-	HYPH
cord-259748-x7dq1sy4	417	20	STING	sting	NN
cord-259748-x7dq1sy4	417	21	-	-	HYPH
cord-259748-x7dq1sy4	417	22	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	417	23	,	,	,
cord-259748-x7dq1sy4	417	24	contrary	contrary	JJ
cord-259748-x7dq1sy4	417	25	to	to	IN
cord-259748-x7dq1sy4	417	26	previous	previous	JJ
cord-259748-x7dq1sy4	417	27	findings	finding	NNS
cord-259748-x7dq1sy4	417	28	(	(	-LRB-
cord-259748-x7dq1sy4	417	29	251	251	CD
cord-259748-x7dq1sy4	417	30	)	)	-RRB-
cord-259748-x7dq1sy4	417	31	.	.	.
cord-259748-x7dq1sy4	418	1	Immune	immune	NN
cord-259748-x7dq1sy4	418	2	-	-	HYPH
cord-259748-x7dq1sy4	418	3	system	system	NN
cord-259748-x7dq1sy4	418	4	interactions	interaction	NNS
cord-259748-x7dq1sy4	418	5	with	with	IN
cord-259748-x7dq1sy4	418	6	tumor	tumor	NN
cord-259748-x7dq1sy4	418	7	cells	cell	NNS
cord-259748-x7dq1sy4	418	8	are	be	VBP
cord-259748-x7dq1sy4	418	9	complicated	complicated	JJ
cord-259748-x7dq1sy4	418	10	.	.	.
cord-259748-x7dq1sy4	419	1	The	the	DT
cord-259748-x7dq1sy4	419	2	effect	effect	NN
cord-259748-x7dq1sy4	419	3	of	of	IN
cord-259748-x7dq1sy4	419	4	cGAS	cgas	JJ
cord-259748-x7dq1sy4	419	5	-	-	HYPH
cord-259748-x7dq1sy4	419	6	STING	sting	NN
cord-259748-x7dq1sy4	419	7	on	on	IN
cord-259748-x7dq1sy4	419	8	cancer	cancer	NN
cord-259748-x7dq1sy4	419	9	is	be	VBZ
cord-259748-x7dq1sy4	419	10	dependent	dependent	JJ
cord-259748-x7dq1sy4	419	11	on	on	IN
cord-259748-x7dq1sy4	419	12	the	the	DT
cord-259748-x7dq1sy4	419	13	type	type	NN
cord-259748-x7dq1sy4	419	14	of	of	IN
cord-259748-x7dq1sy4	419	15	tumor	tumor	NN
cord-259748-x7dq1sy4	419	16	,	,	,
cord-259748-x7dq1sy4	419	17	host	host	NN
cord-259748-x7dq1sy4	419	18	immune	immune	JJ
cord-259748-x7dq1sy4	419	19	state	state	NN
cord-259748-x7dq1sy4	419	20	,	,	,
cord-259748-x7dq1sy4	419	21	activated	activate	VBN
cord-259748-x7dq1sy4	419	22	cell	cell	NN
cord-259748-x7dq1sy4	419	23	types	type	NNS
cord-259748-x7dq1sy4	419	24	,	,	,
cord-259748-x7dq1sy4	419	25	therapeutic	therapeutic	JJ
cord-259748-x7dq1sy4	419	26	intervention	intervention	NN
cord-259748-x7dq1sy4	419	27	,	,	,
cord-259748-x7dq1sy4	419	28	and	and	CC
cord-259748-x7dq1sy4	419	29	the	the	DT
cord-259748-x7dq1sy4	419	30	magnitude	magnitude	NN
cord-259748-x7dq1sy4	419	31	of	of	IN
cord-259748-x7dq1sy4	419	32	cGAS	cgas	JJ
cord-259748-x7dq1sy4	419	33	-	-	HYPH
cord-259748-x7dq1sy4	419	34	STING	sting	NN
cord-259748-x7dq1sy4	419	35	activation	activation	NN
cord-259748-x7dq1sy4	419	36	.	.	.
cord-259748-x7dq1sy4	420	1	Like	like	IN
cord-259748-x7dq1sy4	420	2	inflammation	inflammation	NN
cord-259748-x7dq1sy4	420	3	generated	generate	VBN
cord-259748-x7dq1sy4	420	4	by	by	IN
cord-259748-x7dq1sy4	420	5	cGAS	cgas	NN
cord-259748-x7dq1sy4	420	6	-	-	HYPH
cord-259748-x7dq1sy4	420	7	STING	sting	NN
cord-259748-x7dq1sy4	420	8	,	,	,
cord-259748-x7dq1sy4	420	9	a	a	DT
cord-259748-x7dq1sy4	420	10	time	time	NN
cord-259748-x7dq1sy4	420	11	-	-	HYPH
cord-259748-x7dq1sy4	420	12	dependent	dependent	JJ
cord-259748-x7dq1sy4	420	13	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	420	14	anti	anti	JJ
cord-259748-x7dq1sy4	420	15	-	-	JJ
cord-259748-x7dq1sy4	420	16	tumor	tumor	JJ
cord-259748-x7dq1sy4	420	17	response	response	NN
cord-259748-x7dq1sy4	420	18	mediated	mediate	VBN
cord-259748-x7dq1sy4	420	19	by	by	IN
cord-259748-x7dq1sy4	420	20	cGAS	cgas	NN
cord-259748-x7dq1sy4	420	21	-	-	HYPH
cord-259748-x7dq1sy4	420	22	STING	sting	NN
cord-259748-x7dq1sy4	420	23	may	may	MD
cord-259748-x7dq1sy4	420	24	be	be	VB
cord-259748-x7dq1sy4	420	25	present	present	JJ
cord-259748-x7dq1sy4	420	26	.	.	.
cord-259748-x7dq1sy4	421	1	Temporary	temporary	JJ
cord-259748-x7dq1sy4	421	2	activation	activation	NN
cord-259748-x7dq1sy4	421	3	of	of	IN
cord-259748-x7dq1sy4	421	4	cGAS	cgas	NN
cord-259748-x7dq1sy4	421	5	-	-	HYPH
cord-259748-x7dq1sy4	421	6	STING	sting	NN
cord-259748-x7dq1sy4	421	7	in	in	IN
cord-259748-x7dq1sy4	421	8	innate	innate	JJ
cord-259748-x7dq1sy4	421	9	immune	immune	JJ
cord-259748-x7dq1sy4	421	10	cells	cell	NNS
cord-259748-x7dq1sy4	421	11	could	could	MD
cord-259748-x7dq1sy4	421	12	enhance	enhance	VB
cord-259748-x7dq1sy4	421	13	the	the	DT
cord-259748-x7dq1sy4	421	14	anti	anti	JJ
cord-259748-x7dq1sy4	421	15	-	-	JJ
cord-259748-x7dq1sy4	421	16	tumor	tumor	JJ
cord-259748-x7dq1sy4	421	17	effect	effect	NN
cord-259748-x7dq1sy4	421	18	,	,	,
cord-259748-x7dq1sy4	421	19	whereas	whereas	IN
cord-259748-x7dq1sy4	421	20	sustained	sustained	JJ
cord-259748-x7dq1sy4	421	21	activation	activation	NN
cord-259748-x7dq1sy4	421	22	of	of	IN
cord-259748-x7dq1sy4	421	23	cGAS	cgas	NN
cord-259748-x7dq1sy4	421	24	-	-	HYPH
cord-259748-x7dq1sy4	421	25	STING	sting	NN
cord-259748-x7dq1sy4	421	26	might	may	MD
cord-259748-x7dq1sy4	421	27	induce	induce	VB
cord-259748-x7dq1sy4	421	28	immune	immune	JJ
cord-259748-x7dq1sy4	421	29	tolerance	tolerance	NN
cord-259748-x7dq1sy4	421	30	of	of	IN
cord-259748-x7dq1sy4	421	31	the	the	DT
cord-259748-x7dq1sy4	421	32	tumor	tumor	NN
cord-259748-x7dq1sy4	421	33	.	.	.
cord-259748-x7dq1sy4	422	1	More	More	JJR
cord-259748-x7dq1sy4	422	2	investigations	investigation	NNS
cord-259748-x7dq1sy4	422	3	are	be	VBP
cord-259748-x7dq1sy4	422	4	necessary	necessary	JJ
cord-259748-x7dq1sy4	422	5	to	to	TO
cord-259748-x7dq1sy4	422	6	ascertain	ascertain	VB
cord-259748-x7dq1sy4	422	7	the	the	DT
cord-259748-x7dq1sy4	422	8	exact	exact	JJ
cord-259748-x7dq1sy4	422	9	role	role	NN
cord-259748-x7dq1sy4	422	10	of	of	IN
cord-259748-x7dq1sy4	422	11	cGAS	cgas	NN
cord-259748-x7dq1sy4	422	12	-	-	HYPH
cord-259748-x7dq1sy4	422	13	STING	sting	NN
cord-259748-x7dq1sy4	422	14	in	in	IN
cord-259748-x7dq1sy4	422	15	oncology	oncology	NN
cord-259748-x7dq1sy4	422	16	,	,	,
cord-259748-x7dq1sy4	422	17	and	and	CC
cord-259748-x7dq1sy4	422	18	elucidate	elucidate	VB
cord-259748-x7dq1sy4	422	19	the	the	DT
cord-259748-x7dq1sy4	422	20	specific	specific	JJ
cord-259748-x7dq1sy4	422	21	advantages	advantage	NNS
cord-259748-x7dq1sy4	422	22	and	and	CC
cord-259748-x7dq1sy4	422	23	adverse	adverse	JJ
cord-259748-x7dq1sy4	422	24	effects	effect	NNS
cord-259748-x7dq1sy4	422	25	of	of	IN
cord-259748-x7dq1sy4	422	26	targeting	target	VBG
cord-259748-x7dq1sy4	422	27	the	the	DT
cord-259748-x7dq1sy4	422	28	cGAS	cgas	JJ
cord-259748-x7dq1sy4	422	29	-	-	HYPH
cord-259748-x7dq1sy4	422	30	STING	sting	NN
cord-259748-x7dq1sy4	422	31	pathway	pathway	NN
cord-259748-x7dq1sy4	422	32	in	in	IN
cord-259748-x7dq1sy4	422	33	cancer	cancer	NN
cord-259748-x7dq1sy4	422	34	therapy	therapy	NN
cord-259748-x7dq1sy4	422	35	(	(	-LRB-
cord-259748-x7dq1sy4	422	36	Figure	figure	NN
cord-259748-x7dq1sy4	422	37	5	5	CD
cord-259748-x7dq1sy4	422	38	)	)	-RRB-
cord-259748-x7dq1sy4	422	39	.	.	.
cord-259748-x7dq1sy4	423	1	Considering	consider	VBG
cord-259748-x7dq1sy4	423	2	the	the	DT
cord-259748-x7dq1sy4	423	3	pivotal	pivotal	JJ
cord-259748-x7dq1sy4	423	4	role	role	NN
cord-259748-x7dq1sy4	423	5	of	of	IN
cord-259748-x7dq1sy4	423	6	the	the	DT
cord-259748-x7dq1sy4	423	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	423	8	-	-	HYPH
cord-259748-x7dq1sy4	423	9	STING	sting	NN
cord-259748-x7dq1sy4	423	10	pathway	pathway	NN
cord-259748-x7dq1sy4	423	11	in	in	IN
cord-259748-x7dq1sy4	423	12	infection	infection	NN
cord-259748-x7dq1sy4	423	13	,	,	,
cord-259748-x7dq1sy4	423	14	inflammation	inflammation	NN
cord-259748-x7dq1sy4	423	15	and	and	CC
cord-259748-x7dq1sy4	423	16	cancer	cancer	NN
cord-259748-x7dq1sy4	423	17	,	,	,
cord-259748-x7dq1sy4	423	18	positive	positive	JJ
cord-259748-x7dq1sy4	423	19	modulation	modulation	NN
cord-259748-x7dq1sy4	423	20	of	of	IN
cord-259748-x7dq1sy4	423	21	the	the	DT
cord-259748-x7dq1sy4	423	22	pathway	pathway	NN
cord-259748-x7dq1sy4	423	23	signaling	signaling	NN
cord-259748-x7dq1sy4	423	24	is	be	VBZ
cord-259748-x7dq1sy4	423	25	a	a	DT
cord-259748-x7dq1sy4	423	26	promising	promising	JJ
cord-259748-x7dq1sy4	423	27	way	way	NN
cord-259748-x7dq1sy4	423	28	to	to	TO
cord-259748-x7dq1sy4	423	29	enhance	enhance	VB
cord-259748-x7dq1sy4	423	30	the	the	DT
cord-259748-x7dq1sy4	423	31	immune	immune	JJ
cord-259748-x7dq1sy4	423	32	state	state	NN
cord-259748-x7dq1sy4	423	33	and	and	CC
cord-259748-x7dq1sy4	423	34	restrict	restrict	VB
cord-259748-x7dq1sy4	423	35	microorganisms	microorganism	NNS
cord-259748-x7dq1sy4	423	36	or	or	CC
cord-259748-x7dq1sy4	423	37	heterogeneous	heterogeneous	JJ
cord-259748-x7dq1sy4	423	38	cells	cell	NNS
cord-259748-x7dq1sy4	423	39	,	,	,
cord-259748-x7dq1sy4	423	40	whereas	whereas	IN
cord-259748-x7dq1sy4	423	41	negative	negative	JJ
cord-259748-x7dq1sy4	423	42	modulation	modulation	NN
cord-259748-x7dq1sy4	423	43	can	can	MD
cord-259748-x7dq1sy4	423	44	control	control	VB
cord-259748-x7dq1sy4	423	45	aberrant	aberrant	JJ
cord-259748-x7dq1sy4	423	46	inflammation	inflammation	NN
cord-259748-x7dq1sy4	423	47	.	.	.
cord-259748-x7dq1sy4	424	1	Radiotherapy	radiotherapy	NN
cord-259748-x7dq1sy4	424	2	or	or	CC
cord-259748-x7dq1sy4	424	3	chemotherapy	chemotherapy	NN
cord-259748-x7dq1sy4	424	4	drugs	drug	NNS
cord-259748-x7dq1sy4	424	5	such	such	JJ
cord-259748-x7dq1sy4	424	6	as	as	IN
cord-259748-x7dq1sy4	424	7	cisplatin	cisplatin	NN
cord-259748-x7dq1sy4	424	8	or	or	CC
cord-259748-x7dq1sy4	424	9	cyclophosphamide	cyclophosphamide	NN
cord-259748-x7dq1sy4	424	10	can	can	MD
cord-259748-x7dq1sy4	424	11	induce	induce	VB
cord-259748-x7dq1sy4	424	12	DSBs	dsb	NNS
cord-259748-x7dq1sy4	424	13	and	and	CC
cord-259748-x7dq1sy4	424	14	micronuclei	micronuclei	NNP
cord-259748-x7dq1sy4	424	15	,	,	,
cord-259748-x7dq1sy4	424	16	then	then	RB
cord-259748-x7dq1sy4	424	17	trigger	trigger	VB
cord-259748-x7dq1sy4	424	18	the	the	DT
cord-259748-x7dq1sy4	424	19	cGAS	cgas	JJ
cord-259748-x7dq1sy4	424	20	-	-	HYPH
cord-259748-x7dq1sy4	424	21	STING	sting	NN
cord-259748-x7dq1sy4	424	22	pathway	pathway	NN
cord-259748-x7dq1sy4	424	23	to	to	TO
cord-259748-x7dq1sy4	424	24	enhance	enhance	VB
cord-259748-x7dq1sy4	424	25	tumor	tumor	NN
cord-259748-x7dq1sy4	424	26	immunogenicity	immunogenicity	NN
cord-259748-x7dq1sy4	424	27	(	(	-LRB-
cord-259748-x7dq1sy4	424	28	252	252	CD
cord-259748-x7dq1sy4	424	29	)	)	-RRB-
cord-259748-x7dq1sy4	424	30	(	(	-LRB-
cord-259748-x7dq1sy4	424	31	253	253	CD
cord-259748-x7dq1sy4	424	32	)	)	-RRB-
cord-259748-x7dq1sy4	424	33	(	(	-LRB-
cord-259748-x7dq1sy4	424	34	254	254	CD
cord-259748-x7dq1sy4	424	35	)	)	-RRB-
cord-259748-x7dq1sy4	424	36	.	.	.
cord-259748-x7dq1sy4	425	1	In	in	IN
cord-259748-x7dq1sy4	425	2	addition	addition	NN
cord-259748-x7dq1sy4	425	3	,	,	,
cord-259748-x7dq1sy4	425	4	PARP	PARP	NNP
cord-259748-x7dq1sy4	425	5	inhibitors	inhibitor	NNS
cord-259748-x7dq1sy4	425	6	such	such	JJ
cord-259748-x7dq1sy4	425	7	as	as	IN
cord-259748-x7dq1sy4	425	8	olaparib	olaparib	NNP
cord-259748-x7dq1sy4	425	9	have	have	VBP
cord-259748-x7dq1sy4	425	10	promising	promising	JJ
cord-259748-x7dq1sy4	425	11	effects	effect	NNS
cord-259748-x7dq1sy4	425	12	on	on	IN
cord-259748-x7dq1sy4	425	13	cancer	cancer	NN
cord-259748-x7dq1sy4	425	14	cells	cell	NNS
cord-259748-x7dq1sy4	425	15	lacking	lack	VBG
cord-259748-x7dq1sy4	425	16	BRCA2	brca2	NN
cord-259748-x7dq1sy4	425	17	because	because	IN
cord-259748-x7dq1sy4	425	18	of	of	IN
cord-259748-x7dq1sy4	425	19	their	-PRON-	PRP$
cord-259748-x7dq1sy4	425	20	cooperative	cooperative	JJ
cord-259748-x7dq1sy4	425	21	DNA	dna	NN
cord-259748-x7dq1sy4	425	22	-	-	HYPH
cord-259748-x7dq1sy4	425	23	repair	repair	NN
cord-259748-x7dq1sy4	425	24	functions	function	NNS
cord-259748-x7dq1sy4	425	25	(	(	-LRB-
cord-259748-x7dq1sy4	425	26	253	253	CD
cord-259748-x7dq1sy4	425	27	)	)	-RRB-
cord-259748-x7dq1sy4	425	28	.	.	.
cord-259748-x7dq1sy4	426	1	Although	although	IN
cord-259748-x7dq1sy4	426	2	cGAS	cgas	JJ
cord-259748-x7dq1sy4	426	3	activation	activation	NN
cord-259748-x7dq1sy4	426	4	is	be	VBZ
cord-259748-x7dq1sy4	426	5	inhibited	inhibit	VBN
cord-259748-x7dq1sy4	426	6	by	by	IN
cord-259748-x7dq1sy4	426	7	nucleosomes	nucleosome	NNS
cord-259748-x7dq1sy4	426	8	,	,	,
cord-259748-x7dq1sy4	426	9	taxol	taxol	NN
cord-259748-x7dq1sy4	426	10	can	can	MD
cord-259748-x7dq1sy4	426	11	induce	induce	VB
cord-259748-x7dq1sy4	426	12	mitotic	mitotic	JJ
cord-259748-x7dq1sy4	426	13	cell	cell	NN
cord-259748-x7dq1sy4	426	14	-	-	HYPH
cord-259748-x7dq1sy4	426	15	cycle	cycle	NN
cord-259748-x7dq1sy4	426	16	arrest	arrest	NN
cord-259748-x7dq1sy4	426	17	and	and	CC
cord-259748-x7dq1sy4	426	18	sustain	sustain	VB
cord-259748-x7dq1sy4	426	19	divided	divide	VBN
cord-259748-x7dq1sy4	426	20	chromatin	chromatin	NN
cord-259748-x7dq1sy4	426	21	in	in	IN
cord-259748-x7dq1sy4	426	22	the	the	DT
cord-259748-x7dq1sy4	426	23	cytosol	cytosol	NN
cord-259748-x7dq1sy4	426	24	to	to	TO
cord-259748-x7dq1sy4	426	25	activate	activate	VB
cord-259748-x7dq1sy4	426	26	the	the	DT
cord-259748-x7dq1sy4	426	27	cGAS	cgas	JJ
cord-259748-x7dq1sy4	426	28	-	-	HYPH
cord-259748-x7dq1sy4	426	29	STING	sting	NN
cord-259748-x7dq1sy4	426	30	pathway	pathway	NN
cord-259748-x7dq1sy4	426	31	slowly	slowly	RB
cord-259748-x7dq1sy4	426	32	,	,	,
cord-259748-x7dq1sy4	426	33	and	and	CC
cord-259748-x7dq1sy4	426	34	accumulation	accumulation	NN
cord-259748-x7dq1sy4	426	35	of	of	IN
cord-259748-x7dq1sy4	426	36	signaling	signal	VBG
cord-259748-x7dq1sy4	426	37	could	could	MD
cord-259748-x7dq1sy4	426	38	stimulate	stimulate	VB
cord-259748-x7dq1sy4	426	39	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	426	40	of	of	IN
cord-259748-x7dq1sy4	426	41	cancer	cancer	NN
cord-259748-x7dq1sy4	426	42	cells	cell	NNS
cord-259748-x7dq1sy4	426	43	(	(	-LRB-
cord-259748-x7dq1sy4	426	44	41	41	CD
cord-259748-x7dq1sy4	426	45	)	)	-RRB-
cord-259748-x7dq1sy4	426	46	.	.	.
cord-259748-x7dq1sy4	427	1	Inhibitors	inhibitor	NNS
cord-259748-x7dq1sy4	427	2	of	of	IN
cord-259748-x7dq1sy4	427	3	topoisomerase	topoisomerase	NN
cord-259748-x7dq1sy4	427	4	1	1	CD
cord-259748-x7dq1sy4	427	5	or	or	CC
cord-259748-x7dq1sy4	427	6	2	2	CD
cord-259748-x7dq1sy4	427	7	used	use	VBN
cord-259748-x7dq1sy4	427	8	conventionally	conventionally	RB
cord-259748-x7dq1sy4	427	9	as	as	IN
cord-259748-x7dq1sy4	427	10	chemotherapy	chemotherapy	NN
cord-259748-x7dq1sy4	427	11	drugs	drug	NNS
cord-259748-x7dq1sy4	427	12	trigger	trigger	VBP
cord-259748-x7dq1sy4	427	13	minor	minor	JJ
cord-259748-x7dq1sy4	427	14	damage	damage	NN
cord-259748-x7dq1sy4	427	15	to	to	IN
cord-259748-x7dq1sy4	427	16	DNA	dna	NN
cord-259748-x7dq1sy4	427	17	and	and	CC
cord-259748-x7dq1sy4	427	18	accumulation	accumulation	NN
cord-259748-x7dq1sy4	427	19	of	of	IN
cord-259748-x7dq1sy4	427	20	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	427	21	DNA	dna	NN
cord-259748-x7dq1sy4	427	22	,	,	,
cord-259748-x7dq1sy4	427	23	which	which	WDT
cord-259748-x7dq1sy4	427	24	can	can	MD
cord-259748-x7dq1sy4	427	25	engage	engage	VB
cord-259748-x7dq1sy4	427	26	cGAS	cgas	NN
cord-259748-x7dq1sy4	427	27	and	and	CC
cord-259748-x7dq1sy4	427	28	enhance	enhance	VB
cord-259748-x7dq1sy4	427	29	the	the	DT
cord-259748-x7dq1sy4	427	30	anti	anti	JJ
cord-259748-x7dq1sy4	427	31	-	-	JJ
cord-259748-x7dq1sy4	427	32	tumor	tumor	JJ
cord-259748-x7dq1sy4	427	33	or	or	CC
cord-259748-x7dq1sy4	427	34	anti	anti	JJ
cord-259748-x7dq1sy4	427	35	-	-	JJ
cord-259748-x7dq1sy4	427	36	infection	infection	JJ
cord-259748-x7dq1sy4	427	37	responses	response	NNS
cord-259748-x7dq1sy4	427	38	of	of	IN
cord-259748-x7dq1sy4	427	39	cells	cell	NNS
cord-259748-x7dq1sy4	427	40	(	(	-LRB-
cord-259748-x7dq1sy4	427	41	255	255	CD
cord-259748-x7dq1sy4	427	42	)	)	-RRB-
cord-259748-x7dq1sy4	427	43	(	(	-LRB-
cord-259748-x7dq1sy4	427	44	256	256	CD
cord-259748-x7dq1sy4	427	45	)	)	-RRB-
cord-259748-x7dq1sy4	427	46	(	(	-LRB-
cord-259748-x7dq1sy4	427	47	257	257	CD
cord-259748-x7dq1sy4	427	48	)	)	-RRB-
cord-259748-x7dq1sy4	427	49	.	.	.
cord-259748-x7dq1sy4	428	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	428	2	-	-	:
cord-259748-x7dq1sy4	428	3	STING	sting	NN
cord-259748-x7dq1sy4	428	4	is	be	VBZ
cord-259748-x7dq1sy4	428	5	essential	essential	JJ
cord-259748-x7dq1sy4	428	6	on	on	IN
cord-259748-x7dq1sy4	428	7	anti	anti	JJ
cord-259748-x7dq1sy4	428	8	-	-	JJ
cord-259748-x7dq1sy4	428	9	tumor	tumor	JJ
cord-259748-x7dq1sy4	428	10	immune	immune	JJ
cord-259748-x7dq1sy4	428	11	checkpoints	checkpoint	NNS
cord-259748-x7dq1sy4	428	12	therapies	therapy	NNS
cord-259748-x7dq1sy4	428	13	.	.	.
cord-259748-x7dq1sy4	429	1	For	for	IN
cord-259748-x7dq1sy4	429	2	example	example	NN
cord-259748-x7dq1sy4	429	3	,	,	,
cord-259748-x7dq1sy4	429	4	blockade	blockade	NN
cord-259748-x7dq1sy4	429	5	of	of	IN
cord-259748-x7dq1sy4	429	6	CD47-signal	cd47-signal	CD
cord-259748-x7dq1sy4	429	7	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	429	8	protein	protein	NN
cord-259748-x7dq1sy4	429	9	α	α	NNP
cord-259748-x7dq1sy4	429	10	(	(	-LRB-
cord-259748-x7dq1sy4	429	11	SIRPα	SIRPα	NNS
cord-259748-x7dq1sy4	429	12	)	)	-RRB-
cord-259748-x7dq1sy4	429	13	signaling	signal	VBG
cord-259748-x7dq1sy4	429	14	on	on	IN
cord-259748-x7dq1sy4	429	15	DCs	dc	NNS
cord-259748-x7dq1sy4	429	16	can	can	MD
cord-259748-x7dq1sy4	429	17	activate	activate	VB
cord-259748-x7dq1sy4	429	18	NADPH	NADPH	NNP
cord-259748-x7dq1sy4	429	19	oxidase	oxidase	NN
cord-259748-x7dq1sy4	429	20	2	2	CD
cord-259748-x7dq1sy4	429	21	(	(	-LRB-
cord-259748-x7dq1sy4	429	22	NOX2	NOX2	NNP
cord-259748-x7dq1sy4	429	23	)	)	-RRB-
cord-259748-x7dq1sy4	429	24	and	and	CC
cord-259748-x7dq1sy4	429	25	increase	increase	VB
cord-259748-x7dq1sy4	429	26	the	the	DT
cord-259748-x7dq1sy4	429	27	pH	pH	NNP
cord-259748-x7dq1sy4	429	28	in	in	IN
cord-259748-x7dq1sy4	429	29	phagosomes	phagosome	NNS
cord-259748-x7dq1sy4	429	30	along	along	IN
cord-259748-x7dq1sy4	429	31	with	with	IN
cord-259748-x7dq1sy4	429	32	incomplete	incomplete	JJ
cord-259748-x7dq1sy4	429	33	degradation	degradation	NN
cord-259748-x7dq1sy4	429	34	of	of	IN
cord-259748-x7dq1sy4	429	35	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	429	36	,	,	,
cord-259748-x7dq1sy4	429	37	which	which	WDT
cord-259748-x7dq1sy4	429	38	can	can	MD
cord-259748-x7dq1sy4	429	39	trigger	trigger	VB
cord-259748-x7dq1sy4	429	40	cGAS	cgas	VB
cord-259748-x7dq1sy4	429	41	-	-	HYPH
cord-259748-x7dq1sy4	429	42	STING	sting	NN
cord-259748-x7dq1sy4	429	43	(	(	-LRB-
cord-259748-x7dq1sy4	429	44	129	129	CD
cord-259748-x7dq1sy4	429	45	)	)	-RRB-
cord-259748-x7dq1sy4	429	46	.	.	.
cord-259748-x7dq1sy4	430	1	STING	STING	NNP
cord-259748-x7dq1sy4	430	2	deficiency	deficiency	NN
cord-259748-x7dq1sy4	430	3	in	in	IN
cord-259748-x7dq1sy4	430	4	mice	mouse	NNS
cord-259748-x7dq1sy4	430	5	abrogates	abrogate	VBZ
cord-259748-x7dq1sy4	430	6	the	the	DT
cord-259748-x7dq1sy4	430	7	anti	anti	JJ
cord-259748-x7dq1sy4	430	8	-	-	JJ
cord-259748-x7dq1sy4	430	9	tumor	tumor	JJ
cord-259748-x7dq1sy4	430	10	effect	effect	NN
cord-259748-x7dq1sy4	430	11	of	of	IN
cord-259748-x7dq1sy4	430	12	CD47	CD47	NNP
cord-259748-x7dq1sy4	430	13	blockade	blockade	NN
cord-259748-x7dq1sy4	430	14	(	(	-LRB-
cord-259748-x7dq1sy4	430	15	258	258	CD
cord-259748-x7dq1sy4	430	16	)	)	-RRB-
cord-259748-x7dq1sy4	430	17	.	.	.
cord-259748-x7dq1sy4	431	1	A	a	DT
cord-259748-x7dq1sy4	431	2	similar	similar	JJ
cord-259748-x7dq1sy4	431	3	phenomenon	phenomenon	NN
cord-259748-x7dq1sy4	431	4	also	also	RB
cord-259748-x7dq1sy4	431	5	can	can	MD
cord-259748-x7dq1sy4	431	6	be	be	VB
cord-259748-x7dq1sy4	431	7	seen	see	VBN
cord-259748-x7dq1sy4	431	8	in	in	IN
cord-259748-x7dq1sy4	431	9	anti	anti	JJ
cord-259748-x7dq1sy4	431	10	-	-	JJ
cord-259748-x7dq1sy4	431	11	programmed	programmed	JJ
cord-259748-x7dq1sy4	431	12	cell	cell	NN
cord-259748-x7dq1sy4	431	13	death-1	death-1	NNP
cord-259748-x7dq1sy4	431	14	(	(	-LRB-
cord-259748-x7dq1sy4	431	15	PD-1	PD-1	NNP
cord-259748-x7dq1sy4	431	16	)	)	-RRB-
cord-259748-x7dq1sy4	431	17	therapy	therapy	NN
cord-259748-x7dq1sy4	431	18	(	(	-LRB-
cord-259748-x7dq1sy4	431	19	259	259	CD
cord-259748-x7dq1sy4	431	20	)	)	-RRB-
cord-259748-x7dq1sy4	431	21	.	.	.
cord-259748-x7dq1sy4	432	1	There	there	EX
cord-259748-x7dq1sy4	432	2	is	be	VBZ
cord-259748-x7dq1sy4	432	3	greater	great	JJR
cord-259748-x7dq1sy4	432	4	infiltration	infiltration	NN
cord-259748-x7dq1sy4	432	5	of	of	IN
cord-259748-x7dq1sy4	432	6	IFNγ	IFNγ	NNS
cord-259748-x7dq1sy4	432	7	+	+	CC
cord-259748-x7dq1sy4	432	8	cells	cell	NNS
cord-259748-x7dq1sy4	432	9	and	and	CC
cord-259748-x7dq1sy4	432	10	CD8	CD8	NNP
cord-259748-x7dq1sy4	432	11	+	+	CC
cord-259748-x7dq1sy4	432	12	T	T	NNP
cord-259748-x7dq1sy4	432	13	cells	cell	NNS
cord-259748-x7dq1sy4	432	14	and	and	CC
cord-259748-x7dq1sy4	433	1	PD-1	PD-1	NNP
cord-259748-x7dq1sy4	433	2	/	/	,
cord-259748-x7dq1sy4	433	3	PD-1	PD-1	NNP
cord-259748-x7dq1sy4	433	4	ligand	ligand	NN
cord-259748-x7dq1sy4	433	5	1	1	CD
cord-259748-x7dq1sy4	434	1	(	(	-LRB-
cord-259748-x7dq1sy4	434	2	PD	PD	NNP
cord-259748-x7dq1sy4	434	3	-	-	HYPH
cord-259748-x7dq1sy4	434	4	L1	L1	NNP
cord-259748-x7dq1sy4	434	5	)	)	-RRB-
cord-259748-x7dq1sy4	434	6	expression	expression	NN
cord-259748-x7dq1sy4	434	7	in	in	IN
cord-259748-x7dq1sy4	434	8	TME	TME	NNP
cord-259748-x7dq1sy4	434	9	treated	treat	VBN
cord-259748-x7dq1sy4	434	10	by	by	IN
cord-259748-x7dq1sy4	434	11	STING	sting	NN
cord-259748-x7dq1sy4	434	12	-	-	HYPH
cord-259748-x7dq1sy4	434	13	ligand	ligand	NN
cord-259748-x7dq1sy4	434	14	derivatives	derivative	NNS
cord-259748-x7dq1sy4	434	15	(	(	-LRB-
cord-259748-x7dq1sy4	434	16	260	260	CD
cord-259748-x7dq1sy4	434	17	)	)	-RRB-
cord-259748-x7dq1sy4	434	18	.	.	.
cord-259748-x7dq1sy4	435	1	Therefore	therefore	RB
cord-259748-x7dq1sy4	435	2	,	,	,
cord-259748-x7dq1sy4	435	3	in	in	IN
cord-259748-x7dq1sy4	435	4	several	several	JJ
cord-259748-x7dq1sy4	435	5	types	type	NNS
cord-259748-x7dq1sy4	435	6	of	of	IN
cord-259748-x7dq1sy4	435	7	tumors	tumor	NNS
cord-259748-x7dq1sy4	435	8	,	,	,
cord-259748-x7dq1sy4	435	9	combined	combine	VBN
cord-259748-x7dq1sy4	435	10	administration	administration	NN
cord-259748-x7dq1sy4	435	11	of	of	IN
cord-259748-x7dq1sy4	435	12	a	a	DT
cord-259748-x7dq1sy4	435	13	STING	sting	NN
cord-259748-x7dq1sy4	435	14	agonist	agonist	NN
cord-259748-x7dq1sy4	435	15	and	and	CC
cord-259748-x7dq1sy4	435	16	immune	immune	JJ
cord-259748-x7dq1sy4	435	17	-	-	HYPH
cord-259748-x7dq1sy4	435	18	checkpoint	checkpoint	NN
cord-259748-x7dq1sy4	435	19	antibody	antibody	NN
cord-259748-x7dq1sy4	435	20	could	could	MD
cord-259748-x7dq1sy4	435	21	elicit	elicit	VB
cord-259748-x7dq1sy4	435	22	a	a	DT
cord-259748-x7dq1sy4	435	23	more	more	RBR
cord-259748-x7dq1sy4	435	24	curative	curative	JJ
cord-259748-x7dq1sy4	435	25	outcome	outcome	NN
cord-259748-x7dq1sy4	435	26	compared	compare	VBN
cord-259748-x7dq1sy4	435	27	with	with	IN
cord-259748-x7dq1sy4	435	28	one	one	CD
cord-259748-x7dq1sy4	435	29	therapy	therapy	NN
cord-259748-x7dq1sy4	435	30	alone	alone	RB
cord-259748-x7dq1sy4	435	31	(	(	-LRB-
cord-259748-x7dq1sy4	435	32	238	238	CD
cord-259748-x7dq1sy4	435	33	,	,	,
cord-259748-x7dq1sy4	435	34	261	261	CD
cord-259748-x7dq1sy4	435	35	)	)	-RRB-
cord-259748-x7dq1sy4	435	36	.	.	.
cord-259748-x7dq1sy4	436	1	Viruses	virus	NNS
cord-259748-x7dq1sy4	436	2	can	can	MD
cord-259748-x7dq1sy4	436	3	infect	infect	VB
cord-259748-x7dq1sy4	436	4	cells	cell	NNS
cord-259748-x7dq1sy4	436	5	lacking	lack	VBG
cord-259748-x7dq1sy4	436	6	cGAS	cgas	NN
cord-259748-x7dq1sy4	436	7	-	-	:
cord-259748-x7dq1sy4	436	8	STING	sting	VB
cord-259748-x7dq1sy4	436	9	more	more	RBR
cord-259748-x7dq1sy4	436	10	effectively	effectively	RB
cord-259748-x7dq1sy4	436	11	,	,	,
cord-259748-x7dq1sy4	436	12	and	and	CC
cord-259748-x7dq1sy4	436	13	have	have	VBP
cord-259748-x7dq1sy4	436	14	higher	high	JJR
cord-259748-x7dq1sy4	436	15	oncolytic	oncolytic	JJ
cord-259748-x7dq1sy4	436	16	activity	activity	NN
cord-259748-x7dq1sy4	436	17	compared	compare	VBN
cord-259748-x7dq1sy4	436	18	with	with	IN
cord-259748-x7dq1sy4	436	19	virus	virus	NN
cord-259748-x7dq1sy4	436	20	therapy	therapy	NN
cord-259748-x7dq1sy4	436	21	alone	alone	RB
cord-259748-x7dq1sy4	436	22	.	.	.
cord-259748-x7dq1sy4	437	1	Hence	hence	RB
cord-259748-x7dq1sy4	437	2	,	,	,
cord-259748-x7dq1sy4	437	3	the	the	DT
cord-259748-x7dq1sy4	437	4	use	use	NN
cord-259748-x7dq1sy4	437	5	of	of	IN
cord-259748-x7dq1sy4	437	6	oncolytic	oncolytic	JJ
cord-259748-x7dq1sy4	437	7	viruses	virus	NNS
cord-259748-x7dq1sy4	437	8	such	such	JJ
cord-259748-x7dq1sy4	437	9	as	as	IN
cord-259748-x7dq1sy4	437	10	talimogene	talimogene	NN
cord-259748-x7dq1sy4	437	11	laherparepvec	laherparepvec	NNP
cord-259748-x7dq1sy4	437	12	is	be	VBZ
cord-259748-x7dq1sy4	437	13	beneficial	beneficial	JJ
cord-259748-x7dq1sy4	437	14	for	for	IN
cord-259748-x7dq1sy4	437	15	treating	treat	VBG
cord-259748-x7dq1sy4	437	16	tumors	tumor	NNS
cord-259748-x7dq1sy4	437	17	with	with	IN
cord-259748-x7dq1sy4	437	18	low	low	JJ
cord-259748-x7dq1sy4	437	19	expression	expression	NN
cord-259748-x7dq1sy4	437	20	of	of	IN
cord-259748-x7dq1sy4	437	21	cGAS	cgas	NN
cord-259748-x7dq1sy4	437	22	/	/	SYM
cord-259748-x7dq1sy4	437	23	STING	sting	NN
cord-259748-x7dq1sy4	437	24	.	.	.
cord-259748-x7dq1sy4	438	1	STING	sting	NN
cord-259748-x7dq1sy4	438	2	expression	expression	NN
cord-259748-x7dq1sy4	438	3	can	can	MD
cord-259748-x7dq1sy4	438	4	be	be	VB
cord-259748-x7dq1sy4	438	5	regarded	regard	VBN
cord-259748-x7dq1sy4	438	6	as	as	IN
cord-259748-x7dq1sy4	438	7	a	a	DT
cord-259748-x7dq1sy4	438	8	prognostic	prognostic	JJ
cord-259748-x7dq1sy4	438	9	measurement	measurement	NN
cord-259748-x7dq1sy4	438	10	for	for	IN
cord-259748-x7dq1sy4	438	11	such	such	JJ
cord-259748-x7dq1sy4	438	12	therapy	therapy	NN
cord-259748-x7dq1sy4	438	13	(	(	-LRB-
cord-259748-x7dq1sy4	438	14	262	262	CD
cord-259748-x7dq1sy4	438	15	)	)	-RRB-
cord-259748-x7dq1sy4	438	16	.	.	.
cord-259748-x7dq1sy4	439	1	Some	some	DT
cord-259748-x7dq1sy4	439	2	artificial	artificial	JJ
cord-259748-x7dq1sy4	439	3	analog	analog	NN
cord-259748-x7dq1sy4	439	4	molecules	molecule	NNS
cord-259748-x7dq1sy4	439	5	of	of	IN
cord-259748-x7dq1sy4	439	6	CDNs	cdns	NN
cord-259748-x7dq1sy4	439	7	,	,	,
cord-259748-x7dq1sy4	439	8	such	such	JJ
cord-259748-x7dq1sy4	439	9	as	as	IN
cord-259748-x7dq1sy4	439	10	5,6dimethylxanthenone-4-acetic	5,6dimethylxanthenone-4-acetic	JJ
cord-259748-x7dq1sy4	439	11	acid	acid	NN
cord-259748-x7dq1sy4	439	12	(	(	-LRB-
cord-259748-x7dq1sy4	439	13	DMXAA	DMXAA	NNP
cord-259748-x7dq1sy4	439	14	)	)	-RRB-
cord-259748-x7dq1sy4	439	15	and	and	CC
cord-259748-x7dq1sy4	439	16	10-carboxymethyl-9	10-carboxymethyl-9	CD
cord-259748-x7dq1sy4	439	17	(	(	-LRB-
cord-259748-x7dq1sy4	439	18	10H	10h	LS
cord-259748-x7dq1sy4	439	19	)	)	-RRB-
cord-259748-x7dq1sy4	439	20	acridone	acridone	NNP
cord-259748-x7dq1sy4	439	21	(	(	-LRB-
cord-259748-x7dq1sy4	439	22	CMA	CMA	NNP
cord-259748-x7dq1sy4	439	23	)	)	-RRB-
cord-259748-x7dq1sy4	439	24	can	can	MD
cord-259748-x7dq1sy4	439	25	bind	bind	VB
cord-259748-x7dq1sy4	439	26	the	the	DT
cord-259748-x7dq1sy4	439	27	CDN	CDN	NNP
cord-259748-x7dq1sy4	439	28	pocket	pocket	NN
cord-259748-x7dq1sy4	439	29	of	of	IN
cord-259748-x7dq1sy4	439	30	mouse	mouse	NN
cord-259748-x7dq1sy4	439	31	-	-	HYPH
cord-259748-x7dq1sy4	439	32	specific	specific	JJ
cord-259748-x7dq1sy4	439	33	STING	sting	NN
cord-259748-x7dq1sy4	439	34	dimers	dimer	NNS
cord-259748-x7dq1sy4	439	35	and	and	CC
cord-259748-x7dq1sy4	439	36	promote	promote	VB
cord-259748-x7dq1sy4	439	37	conformational	conformational	JJ
cord-259748-x7dq1sy4	439	38	transition	transition	NN
cord-259748-x7dq1sy4	439	39	of	of	IN
cord-259748-x7dq1sy4	439	40	STING	sting	NN
cord-259748-x7dq1sy4	439	41	from	from	IN
cord-259748-x7dq1sy4	439	42	inactive	inactive	JJ
cord-259748-x7dq1sy4	439	43	"	"	``
cord-259748-x7dq1sy4	439	44	open	open	JJ
cord-259748-x7dq1sy4	439	45	"	"	''
cord-259748-x7dq1sy4	439	46	to	to	IN
cord-259748-x7dq1sy4	439	47	an	an	DT
cord-259748-x7dq1sy4	439	48	active	active	JJ
cord-259748-x7dq1sy4	439	49	"	"	``
cord-259748-x7dq1sy4	439	50	closed	closed	JJ
cord-259748-x7dq1sy4	439	51	"	"	''
cord-259748-x7dq1sy4	439	52	state	state	NN
cord-259748-x7dq1sy4	439	53	(	(	-LRB-
cord-259748-x7dq1sy4	439	54	263	263	CD
cord-259748-x7dq1sy4	439	55	,	,	,
cord-259748-x7dq1sy4	439	56	264	264	CD
cord-259748-x7dq1sy4	439	57	)	)	-RRB-
cord-259748-x7dq1sy4	439	58	.	.	.
cord-259748-x7dq1sy4	440	1	DMXAA	DMXAA	NNP
cord-259748-x7dq1sy4	440	2	showed	show	VBD
cord-259748-x7dq1sy4	440	3	convincing	convincing	JJ
cord-259748-x7dq1sy4	440	4	efficacy	efficacy	NN
cord-259748-x7dq1sy4	440	5	in	in	IN
cord-259748-x7dq1sy4	440	6	restraining	restrain	VBG
cord-259748-x7dq1sy4	440	7	tumors	tumor	NNS
cord-259748-x7dq1sy4	440	8	in	in	IN
cord-259748-x7dq1sy4	440	9	mice	mouse	NNS
cord-259748-x7dq1sy4	440	10	(	(	-LRB-
cord-259748-x7dq1sy4	440	11	265	265	CD
cord-259748-x7dq1sy4	440	12	)	)	-RRB-
cord-259748-x7dq1sy4	440	13	.	.	.
cord-259748-x7dq1sy4	441	1	However	however	RB
cord-259748-x7dq1sy4	441	2	,	,	,
cord-259748-x7dq1sy4	441	3	DMXAA	DMXAA	NNP
cord-259748-x7dq1sy4	441	4	is	be	VBZ
cord-259748-x7dq1sy4	441	5	restricted	restrict	VBN
cord-259748-x7dq1sy4	441	6	in	in	IN
cord-259748-x7dq1sy4	441	7	activating	activate	VBG
cord-259748-x7dq1sy4	441	8	mouse	mouse	NN
cord-259748-x7dq1sy4	441	9	-	-	HYPH
cord-259748-x7dq1sy4	441	10	specific	specific	JJ
cord-259748-x7dq1sy4	441	11	STING	sting	NN
cord-259748-x7dq1sy4	441	12	but	but	CC
cord-259748-x7dq1sy4	441	13	not	not	RB
cord-259748-x7dq1sy4	441	14	humanspecific	humanspecific	JJ
cord-259748-x7dq1sy4	441	15	STING	STING	NNP
cord-259748-x7dq1sy4	441	16	,	,	,
cord-259748-x7dq1sy4	441	17	which	which	WDT
cord-259748-x7dq1sy4	441	18	could	could	MD
cord-259748-x7dq1sy4	441	19	be	be	VB
cord-259748-x7dq1sy4	441	20	an	an	DT
cord-259748-x7dq1sy4	441	21	explanation	explanation	NN
cord-259748-x7dq1sy4	441	22	for	for	IN
cord-259748-x7dq1sy4	441	23	the	the	DT
cord-259748-x7dq1sy4	441	24	failure	failure	NN
cord-259748-x7dq1sy4	441	25	of	of	IN
cord-259748-x7dq1sy4	441	26	DMXAA	DMXAA	NNP
cord-259748-x7dq1sy4	441	27	in	in	IN
cord-259748-x7dq1sy4	441	28	treating	treat	VBG
cord-259748-x7dq1sy4	441	29	1299	1299	CD
cord-259748-x7dq1sy4	441	30	non	non	JJ
cord-259748-x7dq1sy4	441	31	-	-	JJ
cord-259748-x7dq1sy4	441	32	small	small	JJ
cord-259748-x7dq1sy4	441	33	-	-	HYPH
cord-259748-x7dq1sy4	441	34	cell	cell	NN
cord-259748-x7dq1sy4	441	35	lung	lung	NN
cord-259748-x7dq1sy4	441	36	cancer	cancer	NN
cord-259748-x7dq1sy4	441	37	patients	patient	NNS
cord-259748-x7dq1sy4	441	38	in	in	IN
cord-259748-x7dq1sy4	441	39	a	a	DT
cord-259748-x7dq1sy4	441	40	phase	phase	NN
cord-259748-x7dq1sy4	441	41	-	-	HYPH
cord-259748-x7dq1sy4	441	42	III	iii	CD
cord-259748-x7dq1sy4	441	43	clinical	clinical	JJ
cord-259748-x7dq1sy4	441	44	trial	trial	NN
cord-259748-x7dq1sy4	441	45	(	(	-LRB-
cord-259748-x7dq1sy4	442	1	NCT00662597	NCT00662597	NNP
cord-259748-x7dq1sy4	442	2	)	)	-RRB-
cord-259748-x7dq1sy4	442	3	(	(	-LRB-
cord-259748-x7dq1sy4	442	4	266	266	CD
cord-259748-x7dq1sy4	442	5	)	)	-RRB-
cord-259748-x7dq1sy4	442	6	.	.	.
cord-259748-x7dq1sy4	443	1	Nonetheless	nonetheless	RB
cord-259748-x7dq1sy4	443	2	,	,	,
cord-259748-x7dq1sy4	443	3	with	with	IN
cord-259748-x7dq1sy4	443	4	three	three	CD
cord-259748-x7dq1sy4	443	5	substitutions	substitution	NNS
cord-259748-x7dq1sy4	443	6	(	(	-LRB-
cord-259748-x7dq1sy4	443	7	G230I	g230i	VB
cord-259748-x7dq1sy4	443	8	,	,	,
cord-259748-x7dq1sy4	443	9	Q266I	Q266I	NNP
cord-259748-x7dq1sy4	443	10	,	,	,
cord-259748-x7dq1sy4	443	11	and	and	CC
cord-259748-x7dq1sy4	443	12	S162A	S162A	NNP
cord-259748-x7dq1sy4	443	13	)	)	-RRB-
cord-259748-x7dq1sy4	443	14	,	,	,
cord-259748-x7dq1sy4	443	15	human	human	JJ
cord-259748-x7dq1sy4	443	16	STING	sting	NN
cord-259748-x7dq1sy4	443	17	can	can	MD
cord-259748-x7dq1sy4	443	18	also	also	RB
cord-259748-x7dq1sy4	443	19	be	be	VB
cord-259748-x7dq1sy4	443	20	induced	induce	VBN
cord-259748-x7dq1sy4	443	21	by	by	IN
cord-259748-x7dq1sy4	443	22	DMXAA	DMXAA	NNP
cord-259748-x7dq1sy4	443	23	to	to	TO
cord-259748-x7dq1sy4	443	24	undergo	undergo	VB
cord-259748-x7dq1sy4	443	25	conformational	conformational	JJ
cord-259748-x7dq1sy4	443	26	transition	transition	NN
cord-259748-x7dq1sy4	443	27	(	(	-LRB-
cord-259748-x7dq1sy4	443	28	264	264	CD
cord-259748-x7dq1sy4	443	29	)	)	-RRB-
cord-259748-x7dq1sy4	443	30	.	.	.
cord-259748-x7dq1sy4	444	1	Another	another	DT
cord-259748-x7dq1sy4	444	2	new	new	JJ
cord-259748-x7dq1sy4	444	3	compound	compound	NN
cord-259748-x7dq1sy4	444	4	,	,	,
cord-259748-x7dq1sy4	444	5	amidobenzimidazole	amidobenzimidazole	NN
cord-259748-x7dq1sy4	444	6	,	,	,
cord-259748-x7dq1sy4	444	7	has	have	VBZ
cord-259748-x7dq1sy4	444	8	been	be	VBN
cord-259748-x7dq1sy4	444	9	found	find	VBN
cord-259748-x7dq1sy4	444	10	to	to	TO
cord-259748-x7dq1sy4	444	11	be	be	VB
cord-259748-x7dq1sy4	444	12	an	an	DT
cord-259748-x7dq1sy4	444	13	agonist	agonist	NN
cord-259748-x7dq1sy4	444	14	of	of	IN
cord-259748-x7dq1sy4	444	15	STING	sting	NN
cord-259748-x7dq1sy4	444	16	without	without	IN
cord-259748-x7dq1sy4	444	17	lid	lid	NN
cord-259748-x7dq1sy4	444	18	closure	closure	NN
cord-259748-x7dq1sy4	444	19	and	and	CC
cord-259748-x7dq1sy4	444	20	has	have	VBZ
cord-259748-x7dq1sy4	444	21	potential	potential	JJ
cord-259748-x7dq1sy4	444	22	therapeutic	therapeutic	JJ
cord-259748-x7dq1sy4	444	23	value	value	NN
cord-259748-x7dq1sy4	444	24	(	(	-LRB-
cord-259748-x7dq1sy4	444	25	267	267	CD
cord-259748-x7dq1sy4	444	26	)	)	-RRB-
cord-259748-x7dq1sy4	444	27	.	.	.
cord-259748-x7dq1sy4	445	1	Cyclic	cyclic	JJ
cord-259748-x7dq1sy4	445	2	dinucleotides	dinucleotide	NNS
cord-259748-x7dq1sy4	445	3	and	and	CC
cord-259748-x7dq1sy4	445	4	their	-PRON-	PRP$
cord-259748-x7dq1sy4	445	5	derivates	derivate	NNS
cord-259748-x7dq1sy4	445	6	that	that	WDT
cord-259748-x7dq1sy4	445	7	can	can	MD
cord-259748-x7dq1sy4	445	8	stimulate	stimulate	VB
cord-259748-x7dq1sy4	445	9	STING	sting	NN
cord-259748-x7dq1sy4	445	10	directly	directly	RB
cord-259748-x7dq1sy4	445	11	are	be	VBP
cord-259748-x7dq1sy4	445	12	candidate	candidate	NN
cord-259748-x7dq1sy4	445	13	adjuvants	adjuvant	NNS
cord-259748-x7dq1sy4	445	14	to	to	TO
cord-259748-x7dq1sy4	445	15	restrain	restrain	VB
cord-259748-x7dq1sy4	445	16	tumors	tumor	NNS
cord-259748-x7dq1sy4	445	17	.	.	.
cord-259748-x7dq1sy4	446	1	Intratumoral	Intratumoral	NNP
cord-259748-x7dq1sy4	446	2	administration	administration	NN
cord-259748-x7dq1sy4	446	3	of	of	IN
cord-259748-x7dq1sy4	446	4	c	c	NNP
cord-259748-x7dq1sy4	446	5	-	-	HYPH
cord-259748-x7dq1sy4	446	6	dAMP	dAMP	NNP
cord-259748-x7dq1sy4	446	7	,	,	,
cord-259748-x7dq1sy4	446	8	c	c	NNP
cord-259748-x7dq1sy4	446	9	-	-	HYPH
cord-259748-x7dq1sy4	446	10	dGMP	dGMP	NNP
cord-259748-x7dq1sy4	446	11	,	,	,
cord-259748-x7dq1sy4	446	12	or	or	CC
cord-259748-x7dq1sy4	446	13	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	446	14	analogs	analog	NNS
cord-259748-x7dq1sy4	446	15	alone	alone	RB
cord-259748-x7dq1sy4	446	16	or	or	CC
cord-259748-x7dq1sy4	446	17	combined	combine	VBN
cord-259748-x7dq1sy4	446	18	with	with	IN
cord-259748-x7dq1sy4	446	19	other	other	JJ
cord-259748-x7dq1sy4	446	20	adjuvants	adjuvant	NNS
cord-259748-x7dq1sy4	446	21	or	or	CC
cord-259748-x7dq1sy4	446	22	tumor	tumor	NN
cord-259748-x7dq1sy4	446	23	antigens	antigen	NNS
cord-259748-x7dq1sy4	446	24	have	have	VBP
cord-259748-x7dq1sy4	446	25	shown	show	VBN
cord-259748-x7dq1sy4	446	26	anti	anti	JJ
cord-259748-x7dq1sy4	446	27	-	-	JJ
cord-259748-x7dq1sy4	446	28	tumor	tumor	JJ
cord-259748-x7dq1sy4	446	29	effects	effect	NNS
cord-259748-x7dq1sy4	446	30	(	(	-LRB-
cord-259748-x7dq1sy4	446	31	259	259	CD
cord-259748-x7dq1sy4	446	32	,	,	,
cord-259748-x7dq1sy4	446	33	268	268	CD
cord-259748-x7dq1sy4	446	34	)	)	-RRB-
cord-259748-x7dq1sy4	446	35	;	;	:
cord-259748-x7dq1sy4	446	36	phase	phase	NN
cord-259748-x7dq1sy4	446	37	-	-	:
cord-259748-x7dq1sy4	446	38	I	i	NN
cord-259748-x7dq1sy4	446	39	or	or	CC
cord-259748-x7dq1sy4	446	40	II	II	NNP
cord-259748-x7dq1sy4	446	41	clinical	clinical	JJ
cord-259748-x7dq1sy4	446	42	trials	trial	NNS
cord-259748-x7dq1sy4	446	43	(	(	-LRB-
cord-259748-x7dq1sy4	446	44	NCT02675439	nct02675439	UH
cord-259748-x7dq1sy4	446	45	,	,	,
cord-259748-x7dq1sy4	446	46	NCT03172936	NCT03172936	NNP
cord-259748-x7dq1sy4	446	47	,	,	,
cord-259748-x7dq1sy4	446	48	and	and	CC
cord-259748-x7dq1sy4	446	49	NCT03937141	NCT03937141	NNP
cord-259748-x7dq1sy4	446	50	)	)	-RRB-
cord-259748-x7dq1sy4	446	51	of	of	IN
cord-259748-x7dq1sy4	446	52	dithio-(RP	dithio-(RP	NNP
cord-259748-x7dq1sy4	447	1	,	,	,
cord-259748-x7dq1sy4	447	2	RP)-c	RP)-c	NNS
cord-259748-x7dq1sy4	447	3	-	-	HYPH
cord-259748-x7dq1sy4	447	4	dAMP	damp	JJ
cord-259748-x7dq1sy4	447	5	(	(	-LRB-
cord-259748-x7dq1sy4	447	6	known	know	VBN
cord-259748-x7dq1sy4	447	7	as	as	IN
cord-259748-x7dq1sy4	447	8	ADU	ADU	NNP
cord-259748-x7dq1sy4	447	9	-	-	HYPH
cord-259748-x7dq1sy4	447	10	S100	S100	NNP
cord-259748-x7dq1sy4	447	11	)	)	-RRB-
cord-259748-x7dq1sy4	447	12	are	be	VBP
cord-259748-x7dq1sy4	447	13	ongoing	ongoing	JJ
cord-259748-x7dq1sy4	447	14	(	(	-LRB-
cord-259748-x7dq1sy4	447	15	261	261	CD
cord-259748-x7dq1sy4	447	16	)	)	-RRB-
cord-259748-x7dq1sy4	447	17	.	.	.
cord-259748-x7dq1sy4	448	1	To	to	TO
cord-259748-x7dq1sy4	448	2	avoid	avoid	VB
cord-259748-x7dq1sy4	448	3	the	the	DT
cord-259748-x7dq1sy4	448	4	degradation	degradation	NN
cord-259748-x7dq1sy4	448	5	and	and	CC
cord-259748-x7dq1sy4	448	6	ensure	ensure	VB
cord-259748-x7dq1sy4	448	7	maximal	maximal	JJ
cord-259748-x7dq1sy4	448	8	phagocyte	phagocyte	NN
cord-259748-x7dq1sy4	448	9	internalization	internalization	NN
cord-259748-x7dq1sy4	448	10	of	of	IN
cord-259748-x7dq1sy4	448	11	CDNs	CDNs	NNP
cord-259748-x7dq1sy4	448	12	,	,	,
cord-259748-x7dq1sy4	448	13	endosomolytic	endosomolytic	JJ
cord-259748-x7dq1sy4	448	14	nanoparticles	nanoparticle	NNS
cord-259748-x7dq1sy4	448	15	have	have	VBP
cord-259748-x7dq1sy4	448	16	been	be	VBN
cord-259748-x7dq1sy4	448	17	designed	design	VBN
cord-259748-x7dq1sy4	448	18	to	to	TO
cord-259748-x7dq1sy4	448	19	package	package	VB
cord-259748-x7dq1sy4	448	20	and	and	CC
cord-259748-x7dq1sy4	448	21	deliver	deliver	VB
cord-259748-x7dq1sy4	448	22	CDNs	cdn	NNS
cord-259748-x7dq1sy4	448	23	.	.	.
cord-259748-x7dq1sy4	449	1	For	for	IN
cord-259748-x7dq1sy4	449	2	example	example	NN
cord-259748-x7dq1sy4	449	3	,	,	,
cord-259748-x7dq1sy4	449	4	pH	ph	NN
cord-259748-x7dq1sy4	449	5	-	-	JJ
cord-259748-x7dq1sy4	449	6	sensitive	sensitive	JJ
cord-259748-x7dq1sy4	449	7	nanoparticles	nanoparticle	NNS
cord-259748-x7dq1sy4	449	8	(	(	-LRB-
cord-259748-x7dq1sy4	449	9	e.g.	e.g.	RB
cord-259748-x7dq1sy4	449	10	,	,	,
cord-259748-x7dq1sy4	449	11	STINGnanoparticles	STINGnanoparticles	NNP
cord-259748-x7dq1sy4	449	12	)	)	-RRB-
cord-259748-x7dq1sy4	449	13	can	can	MD
cord-259748-x7dq1sy4	449	14	release	release	VB
cord-259748-x7dq1sy4	449	15	their	-PRON-	PRP$
cord-259748-x7dq1sy4	449	16	contents	content	NNS
cord-259748-x7dq1sy4	449	17	if	if	IN
cord-259748-x7dq1sy4	449	18	located	locate	VBN
cord-259748-x7dq1sy4	449	19	in	in	IN
cord-259748-x7dq1sy4	449	20	acidic	acidic	JJ
cord-259748-x7dq1sy4	449	21	endosomal	endosomal	JJ
cord-259748-x7dq1sy4	449	22	environments	environment	NNS
cord-259748-x7dq1sy4	449	23	(	(	-LRB-
cord-259748-x7dq1sy4	449	24	269	269	CD
cord-259748-x7dq1sy4	449	25	)	)	-RRB-
cord-259748-x7dq1sy4	449	26	.	.	.
cord-259748-x7dq1sy4	450	1	For	for	IN
cord-259748-x7dq1sy4	450	2	treatment	treatment	NN
cord-259748-x7dq1sy4	450	3	of	of	IN
cord-259748-x7dq1sy4	450	4	type	type	NN
cord-259748-x7dq1sy4	450	5	-	-	:
cord-259748-x7dq1sy4	450	6	I	-PRON-	PRP
cord-259748-x7dq1sy4	450	7	interferonopathies	interferonopathie	NNS
cord-259748-x7dq1sy4	450	8	,	,	,
cord-259748-x7dq1sy4	450	9	lessons	lesson	NNS
cord-259748-x7dq1sy4	450	10	can	can	MD
cord-259748-x7dq1sy4	450	11	be	be	VB
cord-259748-x7dq1sy4	450	12	taken	take	VBN
cord-259748-x7dq1sy4	450	13	from	from	IN
cord-259748-x7dq1sy4	450	14	the	the	DT
cord-259748-x7dq1sy4	450	15	treatment	treatment	NN
cord-259748-x7dq1sy4	450	16	of	of	IN
cord-259748-x7dq1sy4	450	17	canonical	canonical	JJ
cord-259748-x7dq1sy4	450	18	autoimmune	autoimmune	JJ
cord-259748-x7dq1sy4	450	19	disease	disease	NN
cord-259748-x7dq1sy4	450	20	such	such	JJ
cord-259748-x7dq1sy4	450	21	as	as	IN
cord-259748-x7dq1sy4	450	22	SLE	SLE	NNP
cord-259748-x7dq1sy4	450	23	,	,	,
cord-259748-x7dq1sy4	450	24	but	but	CC
cord-259748-x7dq1sy4	450	25	there	there	EX
cord-259748-x7dq1sy4	450	26	are	be	VBP
cord-259748-x7dq1sy4	450	27	several	several	JJ
cord-259748-x7dq1sy4	450	28	differences	difference	NNS
cord-259748-x7dq1sy4	450	29	.	.	.
cord-259748-x7dq1sy4	451	1	For	for	IN
cord-259748-x7dq1sy4	451	2	example	example	NN
cord-259748-x7dq1sy4	451	3	,	,	,
cord-259748-x7dq1sy4	451	4	it	-PRON-	PRP
cord-259748-x7dq1sy4	451	5	was	be	VBD
cord-259748-x7dq1sy4	451	6	found	find	VBN
cord-259748-x7dq1sy4	451	7	that	that	IN
cord-259748-x7dq1sy4	451	8	corticosteroid	corticosteroid	NN
cord-259748-x7dq1sy4	451	9	pulse	pulse	NN
cord-259748-x7dq1sy4	451	10	therapy	therapy	NN
cord-259748-x7dq1sy4	451	11	,	,	,
cord-259748-x7dq1sy4	451	12	γ	γ	NN
cord-259748-x7dq1sy4	451	13	-	-	HYPH
cord-259748-x7dq1sy4	451	14	immunoglobulins	immunoglobulin	NNS
cord-259748-x7dq1sy4	451	15	,	,	,
cord-259748-x7dq1sy4	451	16	disease	disease	NN
cord-259748-x7dq1sy4	451	17	-	-	HYPH
cord-259748-x7dq1sy4	451	18	modifying	modify	VBG
cord-259748-x7dq1sy4	451	19	anti	anti	JJ
cord-259748-x7dq1sy4	451	20	-	-	JJ
cord-259748-x7dq1sy4	451	21	rheumatic	rheumatic	JJ
cord-259748-x7dq1sy4	451	22	drugs	drug	NNS
cord-259748-x7dq1sy4	451	23	,	,	,
cord-259748-x7dq1sy4	451	24	anti	anti	JJ
cord-259748-x7dq1sy4	451	25	-	-	NN
cord-259748-x7dq1sy4	451	26	CD20	CD20	NNP
cord-259748-x7dq1sy4	451	27	,	,	,
cord-259748-x7dq1sy4	451	28	and	and	CC
cord-259748-x7dq1sy4	451	29	some	some	DT
cord-259748-x7dq1sy4	451	30	immunosuppressants	immunosuppressant	NNS
cord-259748-x7dq1sy4	451	31	(	(	-LRB-
cord-259748-x7dq1sy4	451	32	e.g.	e.g.	RB
cord-259748-x7dq1sy4	451	33	,	,	,
cord-259748-x7dq1sy4	451	34	methotrexate	methotrexate	NNP
cord-259748-x7dq1sy4	451	35	)	)	-RRB-
cord-259748-x7dq1sy4	451	36	have	have	VBP
cord-259748-x7dq1sy4	451	37	limited	limit	VBN
cord-259748-x7dq1sy4	451	38	efficacy	efficacy	NN
cord-259748-x7dq1sy4	451	39	against	against	IN
cord-259748-x7dq1sy4	451	40	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	451	41	(	(	-LRB-
cord-259748-x7dq1sy4	451	42	166	166	CD
cord-259748-x7dq1sy4	451	43	,	,	,
cord-259748-x7dq1sy4	451	44	171	171	CD
cord-259748-x7dq1sy4	451	45	)	)	-RRB-
cord-259748-x7dq1sy4	451	46	.	.	.
cord-259748-x7dq1sy4	452	1	JAK	JAK	NNP
cord-259748-x7dq1sy4	452	2	inhibitors	inhibitor	NNS
cord-259748-x7dq1sy4	452	3	such	such	JJ
cord-259748-x7dq1sy4	452	4	as	as	IN
cord-259748-x7dq1sy4	452	5	ruxolitinib	ruxolitinib	NNP
cord-259748-x7dq1sy4	452	6	,	,	,
cord-259748-x7dq1sy4	452	7	tofacitinib	tofacitinib	NNP
cord-259748-x7dq1sy4	452	8	and	and	CC
cord-259748-x7dq1sy4	452	9	baricitinib	baricitinib	NNP
cord-259748-x7dq1sy4	452	10	that	that	WDT
cord-259748-x7dq1sy4	452	11	reduce	reduce	VBP
cord-259748-x7dq1sy4	452	12	type	type	NN
cord-259748-x7dq1sy4	453	1	-I	-I	NFP
cord-259748-x7dq1sy4	453	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	453	3	downstream	downstream	NN
cord-259748-x7dq1sy4	453	4	signaling	signaling	NN
cord-259748-x7dq1sy4	453	5	have	have	VBP
cord-259748-x7dq1sy4	453	6	shown	show	VBN
cord-259748-x7dq1sy4	453	7	therapeutic	therapeutic	JJ
cord-259748-x7dq1sy4	453	8	value	value	NN
cord-259748-x7dq1sy4	453	9	against	against	IN
cord-259748-x7dq1sy4	453	10	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	453	11	,	,	,
cord-259748-x7dq1sy4	453	12	but	but	CC
cord-259748-x7dq1sy4	453	13	further	further	JJ
cord-259748-x7dq1sy4	453	14	verification	verification	NN
cord-259748-x7dq1sy4	453	15	of	of	IN
cord-259748-x7dq1sy4	453	16	their	-PRON-	PRP$
cord-259748-x7dq1sy4	453	17	efficacy	efficacy	NN
cord-259748-x7dq1sy4	453	18	is	be	VBZ
cord-259748-x7dq1sy4	453	19	needed	need	VBN
cord-259748-x7dq1sy4	453	20	(	(	-LRB-
cord-259748-x7dq1sy4	453	21	270	270	CD
cord-259748-x7dq1sy4	453	22	)	)	-RRB-
cord-259748-x7dq1sy4	453	23	.	.	.
cord-259748-x7dq1sy4	454	1	Moreover	moreover	RB
cord-259748-x7dq1sy4	454	2	,	,	,
cord-259748-x7dq1sy4	454	3	novel	novel	JJ
cord-259748-x7dq1sy4	454	4	immune	immune	JJ
cord-259748-x7dq1sy4	454	5	therapies	therapy	NNS
cord-259748-x7dq1sy4	454	6	,	,	,
cord-259748-x7dq1sy4	454	7	such	such	JJ
cord-259748-x7dq1sy4	454	8	as	as	IN
cord-259748-x7dq1sy4	454	9	anti	anti	JJ
cord-259748-x7dq1sy4	454	10	-	-	JJ
cord-259748-x7dq1sy4	454	11	IFNα	ifnα	JJ
cord-259748-x7dq1sy4	454	12	and	and	CC
cord-259748-x7dq1sy4	454	13	anti	anti	JJ
cord-259748-x7dq1sy4	454	14	-	-	JJ
cord-259748-x7dq1sy4	454	15	IFNAR	ifnar	JJ
cord-259748-x7dq1sy4	454	16	immunoglobin	immunoglobin	NNP
cord-259748-x7dq1sy4	454	17	,	,	,
cord-259748-x7dq1sy4	454	18	are	be	VBP
cord-259748-x7dq1sy4	454	19	in	in	IN
cord-259748-x7dq1sy4	454	20	clinical	clinical	JJ
cord-259748-x7dq1sy4	454	21	trials	trial	NNS
cord-259748-x7dq1sy4	454	22	for	for	IN
cord-259748-x7dq1sy4	454	23	SLE	SLE	NNP
cord-259748-x7dq1sy4	454	24	.	.	.
cord-259748-x7dq1sy4	455	1	These	these	DT
cord-259748-x7dq1sy4	455	2	could	could	MD
cord-259748-x7dq1sy4	455	3	also	also	RB
cord-259748-x7dq1sy4	455	4	be	be	VB
cord-259748-x7dq1sy4	455	5	tested	test	VBN
cord-259748-x7dq1sy4	455	6	against	against	IN
cord-259748-x7dq1sy4	455	7	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	455	8	in	in	IN
cord-259748-x7dq1sy4	455	9	the	the	DT
cord-259748-x7dq1sy4	455	10	future	future	NN
cord-259748-x7dq1sy4	455	11	(	(	-LRB-
cord-259748-x7dq1sy4	455	12	165	165	CD
cord-259748-x7dq1sy4	455	13	)	)	-RRB-
cord-259748-x7dq1sy4	455	14	.	.	.
cord-259748-x7dq1sy4	456	1	Pharmaceutically	Pharmaceutically	NNP
cord-259748-x7dq1sy4	456	2	screening	screening	NN
cord-259748-x7dq1sy4	456	3	has	have	VBZ
cord-259748-x7dq1sy4	456	4	revealed	reveal	VBN
cord-259748-x7dq1sy4	456	5	that	that	IN
cord-259748-x7dq1sy4	456	6	some	some	DT
cord-259748-x7dq1sy4	456	7	antimalaria	antimalaria	NNP
cord-259748-x7dq1sy4	456	8	drugs	drug	NNS
cord-259748-x7dq1sy4	456	9	,	,	,
cord-259748-x7dq1sy4	456	10	such	such	JJ
cord-259748-x7dq1sy4	456	11	as	as	IN
cord-259748-x7dq1sy4	456	12	suramin	suramin	NNP
cord-259748-x7dq1sy4	456	13	,	,	,
cord-259748-x7dq1sy4	456	14	have	have	VBP
cord-259748-x7dq1sy4	456	15	an	an	DT
cord-259748-x7dq1sy4	456	16	inhibitory	inhibitory	JJ
cord-259748-x7dq1sy4	456	17	effect	effect	NN
cord-259748-x7dq1sy4	456	18	on	on	IN
cord-259748-x7dq1sy4	456	19	cGAS	cgas	NN
cord-259748-x7dq1sy4	456	20	by	by	IN
cord-259748-x7dq1sy4	456	21	blockade	blockade	NN
cord-259748-x7dq1sy4	456	22	of	of	IN
cord-259748-x7dq1sy4	456	23	interaction	interaction	NN
cord-259748-x7dq1sy4	456	24	between	between	IN
cord-259748-x7dq1sy4	456	25	DNA	dna	NN
cord-259748-x7dq1sy4	456	26	and	and	CC
cord-259748-x7dq1sy4	456	27	cGAS	cgas	NN
cord-259748-x7dq1sy4	456	28	(	(	-LRB-
cord-259748-x7dq1sy4	456	29	271	271	CD
cord-259748-x7dq1sy4	456	30	)	)	-RRB-
cord-259748-x7dq1sy4	456	31	.	.	.
cord-259748-x7dq1sy4	457	1	In	in	IN
cord-259748-x7dq1sy4	457	2	addition	addition	NN
cord-259748-x7dq1sy4	457	3	,	,	,
cord-259748-x7dq1sy4	457	4	novel	novel	JJ
cord-259748-x7dq1sy4	457	5	small	small	JJ
cord-259748-x7dq1sy4	457	6	molecules	molecule	NNS
cord-259748-x7dq1sy4	457	7	such	such	JJ
cord-259748-x7dq1sy4	457	8	as	as	IN
cord-259748-x7dq1sy4	457	9	RU320521	ru320521	NN
cord-259748-x7dq1sy4	457	10	or	or	CC
cord-259748-x7dq1sy4	457	11	G150	G150	NNPS
cord-259748-x7dq1sy4	457	12	can	can	MD
cord-259748-x7dq1sy4	457	13	occupy	occupy	VB
cord-259748-x7dq1sy4	457	14	the	the	DT
cord-259748-x7dq1sy4	457	15	enzymatic	enzymatic	JJ
cord-259748-x7dq1sy4	457	16	pocket	pocket	NN
cord-259748-x7dq1sy4	457	17	of	of	IN
cord-259748-x7dq1sy4	457	18	species	species	NN
cord-259748-x7dq1sy4	457	19	-	-	HYPH
cord-259748-x7dq1sy4	457	20	specific	specific	JJ
cord-259748-x7dq1sy4	457	21	cGAS	cgas	NN
cord-259748-x7dq1sy4	457	22	to	to	TO
cord-259748-x7dq1sy4	457	23	abrogate	abrogate	VB
cord-259748-x7dq1sy4	457	24	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	457	25	synthesis	synthesis	NN
cord-259748-x7dq1sy4	457	26	(	(	-LRB-
cord-259748-x7dq1sy4	457	27	272	272	CD
cord-259748-x7dq1sy4	457	28	,	,	,
cord-259748-x7dq1sy4	457	29	273	273	CD
cord-259748-x7dq1sy4	457	30	)	)	-RRB-
cord-259748-x7dq1sy4	457	31	.	.	.
cord-259748-x7dq1sy4	458	1	Recently	recently	RB
cord-259748-x7dq1sy4	458	2	,	,	,
cord-259748-x7dq1sy4	458	3	a	a	DT
cord-259748-x7dq1sy4	458	4	study	study	NN
cord-259748-x7dq1sy4	458	5	found	find	VBD
cord-259748-x7dq1sy4	458	6	that	that	IN
cord-259748-x7dq1sy4	458	7	aspirin	aspirin	NN
cord-259748-x7dq1sy4	458	8	can	can	MD
cord-259748-x7dq1sy4	458	9	acetylate	acetylate	VB
cord-259748-x7dq1sy4	458	10	cGAS	cgas	NN
cord-259748-x7dq1sy4	458	11	at	at	IN
cord-259748-x7dq1sy4	458	12	three	three	CD
cord-259748-x7dq1sy4	458	13	lysine	lysine	NN
cord-259748-x7dq1sy4	458	14	residues	residue	NNS
cord-259748-x7dq1sy4	458	15	and	and	CC
cord-259748-x7dq1sy4	458	16	block	block	NN
cord-259748-x7dq1sy4	458	17	cGAS	cgas	NN
cord-259748-x7dq1sy4	458	18	activity	activity	NN
cord-259748-x7dq1sy4	458	19	(	(	-LRB-
cord-259748-x7dq1sy4	458	20	274	274	CD
cord-259748-x7dq1sy4	458	21	)	)	-RRB-
cord-259748-x7dq1sy4	458	22	.	.	.
cord-259748-x7dq1sy4	459	1	With	with	IN
cord-259748-x7dq1sy4	459	2	regard	regard	NN
cord-259748-x7dq1sy4	459	3	to	to	IN
cord-259748-x7dq1sy4	459	4	STING	sting	NN
cord-259748-x7dq1sy4	459	5	,	,	,
cord-259748-x7dq1sy4	459	6	the	the	DT
cord-259748-x7dq1sy4	459	7	cyclopeptide	cyclopeptide	NN
cord-259748-x7dq1sy4	459	8	Astin	Astin	NNP
cord-259748-x7dq1sy4	459	9	C	C	NNP
cord-259748-x7dq1sy4	459	10	can	can	MD
cord-259748-x7dq1sy4	459	11	block	block	VB
cord-259748-x7dq1sy4	459	12	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	459	13	recruitment	recruitment	NN
cord-259748-x7dq1sy4	459	14	onto	onto	IN
cord-259748-x7dq1sy4	459	15	the	the	DT
cord-259748-x7dq1sy4	459	16	STING	sting	NN
cord-259748-x7dq1sy4	459	17	signalosome	signalosome	NN
cord-259748-x7dq1sy4	459	18	(	(	-LRB-
cord-259748-x7dq1sy4	459	19	275	275	CD
cord-259748-x7dq1sy4	459	20	)	)	-RRB-
cord-259748-x7dq1sy4	459	21	.	.	.
cord-259748-x7dq1sy4	460	1	The	the	DT
cord-259748-x7dq1sy4	460	2	molecule	molecule	NN
cord-259748-x7dq1sy4	460	3	H-151	h-151	NN
cord-259748-x7dq1sy4	460	4	can	can	MD
cord-259748-x7dq1sy4	460	5	block	block	VB
cord-259748-x7dq1sy4	460	6	the	the	DT
cord-259748-x7dq1sy4	460	7	palmitoylation	palmitoylation	NN
cord-259748-x7dq1sy4	460	8	of	of	IN
cord-259748-x7dq1sy4	460	9	human	human	JJ
cord-259748-x7dq1sy4	460	10	-	-	HYPH
cord-259748-x7dq1sy4	460	11	STING	sting	NN
cord-259748-x7dq1sy4	460	12	(	(	-LRB-
cord-259748-x7dq1sy4	460	13	276	276	CD
cord-259748-x7dq1sy4	460	14	)	)	-RRB-
cord-259748-x7dq1sy4	460	15	.	.	.
cord-259748-x7dq1sy4	461	1	All	all	DT
cord-259748-x7dq1sy4	461	2	of	of	IN
cord-259748-x7dq1sy4	461	3	these	these	DT
cord-259748-x7dq1sy4	461	4	agents	agent	NNS
cord-259748-x7dq1sy4	461	5	are	be	VBP
cord-259748-x7dq1sy4	461	6	potential	potential	JJ
cord-259748-x7dq1sy4	461	7	candidates	candidate	NNS
cord-259748-x7dq1sy4	461	8	for	for	IN
cord-259748-x7dq1sy4	461	9	alleviating	alleviate	VBG
cord-259748-x7dq1sy4	461	10	type	type	NN
cord-259748-x7dq1sy4	461	11	-	-	:
cord-259748-x7dq1sy4	461	12	I	-PRON-	PRP
cord-259748-x7dq1sy4	461	13	interferonopathies	interferonopathie	NNS
cord-259748-x7dq1sy4	461	14	.	.	.
cord-259748-x7dq1sy4	462	1	The	the	DT
cord-259748-x7dq1sy4	462	2	cGAS	cgas	JJ
cord-259748-x7dq1sy4	462	3	-	-	HYPH
cord-259748-x7dq1sy4	462	4	STING	sting	NN
cord-259748-x7dq1sy4	462	5	pathway	pathway	NN
cord-259748-x7dq1sy4	462	6	is	be	VBZ
cord-259748-x7dq1sy4	462	7	primarily	primarily	RB
cord-259748-x7dq1sy4	462	8	responsible	responsible	JJ
cord-259748-x7dq1sy4	462	9	for	for	IN
cord-259748-x7dq1sy4	462	10	the	the	DT
cord-259748-x7dq1sy4	462	11	modulation	modulation	NN
cord-259748-x7dq1sy4	462	12	of	of	IN
cord-259748-x7dq1sy4	462	13	immune	immune	JJ
cord-259748-x7dq1sy4	462	14	response	response	NN
cord-259748-x7dq1sy4	462	15	in	in	IN
cord-259748-x7dq1sy4	462	16	cells	cell	NNS
cord-259748-x7dq1sy4	462	17	when	when	WRB
cord-259748-x7dq1sy4	462	18	facing	face	VBG
cord-259748-x7dq1sy4	462	19	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	462	20	dsDNA	dsdna	JJ
cord-259748-x7dq1sy4	462	21	challenge	challenge	NN
cord-259748-x7dq1sy4	462	22	.	.	.
cord-259748-x7dq1sy4	463	1	Moreover	moreover	RB
cord-259748-x7dq1sy4	463	2	,	,	,
cord-259748-x7dq1sy4	463	3	it	-PRON-	PRP
cord-259748-x7dq1sy4	463	4	is	be	VBZ
cord-259748-x7dq1sy4	463	5	complicatedly	complicatedly	RB
cord-259748-x7dq1sy4	463	6	cross	cross	JJ
cord-259748-x7dq1sy4	463	7	-	-	JJ
cord-259748-x7dq1sy4	463	8	regulated	regulate	VBN
cord-259748-x7dq1sy4	463	9	by	by	IN
cord-259748-x7dq1sy4	463	10	other	other	JJ
cord-259748-x7dq1sy4	463	11	cellular	cellular	JJ
cord-259748-x7dq1sy4	463	12	processes	process	NNS
cord-259748-x7dq1sy4	463	13	or	or	CC
cord-259748-x7dq1sy4	463	14	cellular	cellular	JJ
cord-259748-x7dq1sy4	463	15	signaling	signaling	NN
cord-259748-x7dq1sy4	463	16	networks	network	NNS
cord-259748-x7dq1sy4	463	17	.	.	.
cord-259748-x7dq1sy4	464	1	The	the	DT
cord-259748-x7dq1sy4	464	2	exact	exact	JJ
cord-259748-x7dq1sy4	464	3	fundamental	fundamental	JJ
cord-259748-x7dq1sy4	464	4	mechanism	mechanism	NN
cord-259748-x7dq1sy4	464	5	of	of	IN
cord-259748-x7dq1sy4	464	6	the	the	DT
cord-259748-x7dq1sy4	464	7	pathway	pathway	NN
cord-259748-x7dq1sy4	464	8	in	in	IN
cord-259748-x7dq1sy4	464	9	cells	cell	NNS
cord-259748-x7dq1sy4	464	10	and	and	CC
cord-259748-x7dq1sy4	464	11	the	the	DT
cord-259748-x7dq1sy4	464	12	effect	effect	NN
cord-259748-x7dq1sy4	464	13	on	on	IN
cord-259748-x7dq1sy4	464	14	the	the	DT
cord-259748-x7dq1sy4	464	15	whole	whole	JJ
cord-259748-x7dq1sy4	464	16	organism	organism	NN
cord-259748-x7dq1sy4	464	17	in	in	IN
cord-259748-x7dq1sy4	464	18	specific	specific	JJ
cord-259748-x7dq1sy4	464	19	states	state	NNS
cord-259748-x7dq1sy4	464	20	is	be	VBZ
cord-259748-x7dq1sy4	464	21	not	not	RB
cord-259748-x7dq1sy4	464	22	completely	completely	RB
cord-259748-x7dq1sy4	464	23	clear	clear	JJ
cord-259748-x7dq1sy4	464	24	and	and	CC
cord-259748-x7dq1sy4	464	25	requires	require	VBZ
cord-259748-x7dq1sy4	464	26	further	further	JJ
cord-259748-x7dq1sy4	464	27	investigation	investigation	NN
cord-259748-x7dq1sy4	464	28	.	.	.
cord-259748-x7dq1sy4	465	1	In	in	IN
cord-259748-x7dq1sy4	465	2	conclusion	conclusion	NN
cord-259748-x7dq1sy4	465	3	,	,	,
cord-259748-x7dq1sy4	465	4	the	the	DT
cord-259748-x7dq1sy4	465	5	cGAS	cgas	JJ
cord-259748-x7dq1sy4	465	6	-	-	HYPH
cord-259748-x7dq1sy4	465	7	STING	sting	NN
cord-259748-x7dq1sy4	465	8	pathway	pathway	NN
cord-259748-x7dq1sy4	465	9	has	have	VBZ
cord-259748-x7dq1sy4	465	10	dichotomous	dichotomous	JJ
cord-259748-x7dq1sy4	465	11	roles	role	NNS
cord-259748-x7dq1sy4	465	12	in	in	IN
cord-259748-x7dq1sy4	465	13	the	the	DT
cord-259748-x7dq1sy4	465	14	immune	immune	JJ
cord-259748-x7dq1sy4	465	15	system	system	NN
cord-259748-x7dq1sy4	465	16	.	.	.
cord-259748-x7dq1sy4	466	1	In	in	IN
cord-259748-x7dq1sy4	466	2	general	general	JJ
cord-259748-x7dq1sy4	466	3	,	,	,
cord-259748-x7dq1sy4	466	4	cGAS	cgas	JJ
cord-259748-x7dq1sy4	466	5	-	-	HYPH
cord-259748-x7dq1sy4	466	6	STING	sting	NN
cord-259748-x7dq1sy4	466	7	-	-	HYPH
cord-259748-x7dq1sy4	466	8	type	type	NN
cord-259748-x7dq1sy4	466	9	-	-	:
cord-259748-x7dq1sy4	466	10	I	-PRON-	PRP
cord-259748-x7dq1sy4	466	11	IFN	IFN	NNP
cord-259748-x7dq1sy4	466	12	signaling	signal	VBG
cord-259748-x7dq1sy4	466	13	can	can	MD
cord-259748-x7dq1sy4	466	14	promote	promote	VB
cord-259748-x7dq1sy4	466	15	the	the	DT
cord-259748-x7dq1sy4	466	16	innate	innate	JJ
cord-259748-x7dq1sy4	466	17	immune	immune	JJ
cord-259748-x7dq1sy4	466	18	response	response	NN
cord-259748-x7dq1sy4	466	19	in	in	IN
cord-259748-x7dq1sy4	466	20	myeloid	myeloid	NN
cord-259748-x7dq1sy4	466	21	cells	cell	NNS
cord-259748-x7dq1sy4	466	22	but	but	CC
cord-259748-x7dq1sy4	466	23	alleviate	alleviate	VBP
cord-259748-x7dq1sy4	466	24	the	the	DT
cord-259748-x7dq1sy4	466	25	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	466	26	immune	immune	JJ
cord-259748-x7dq1sy4	466	27	response	response	NN
cord-259748-x7dq1sy4	466	28	exerted	exert	VBN
cord-259748-x7dq1sy4	466	29	by	by	IN
cord-259748-x7dq1sy4	466	30	T	T	NNP
cord-259748-x7dq1sy4	466	31	cells	cell	NNS
cord-259748-x7dq1sy4	466	32	and	and	CC
cord-259748-x7dq1sy4	466	33	B	b	NN
cord-259748-x7dq1sy4	466	34	cells	cell	NNS
cord-259748-x7dq1sy4	466	35	.	.	.
cord-259748-x7dq1sy4	467	1	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	467	2	shows	show	VBZ
cord-259748-x7dq1sy4	467	3	high	high	JJ
cord-259748-x7dq1sy4	467	4	expression	expression	NN
cord-259748-x7dq1sy4	467	5	in	in	IN
cord-259748-x7dq1sy4	467	6	APCs	apc	NNS
cord-259748-x7dq1sy4	467	7	such	such	JJ
cord-259748-x7dq1sy4	467	8	as	as	IN
cord-259748-x7dq1sy4	467	9	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	467	10	and	and	CC
cord-259748-x7dq1sy4	467	11	DCs	dc	NNS
cord-259748-x7dq1sy4	467	12	,	,	,
cord-259748-x7dq1sy4	467	13	but	but	CC
cord-259748-x7dq1sy4	467	14	STING	STING	NNP
cord-259748-x7dq1sy4	467	15	is	be	VBZ
cord-259748-x7dq1sy4	467	16	expressed	express	VBN
cord-259748-x7dq1sy4	467	17	in	in	IN
cord-259748-x7dq1sy4	467	18	most	most	JJS
cord-259748-x7dq1sy4	467	19	cells	cell	NNS
cord-259748-x7dq1sy4	467	20	(	(	-LRB-
cord-259748-x7dq1sy4	467	21	10	10	CD
cord-259748-x7dq1sy4	467	22	)	)	-RRB-
cord-259748-x7dq1sy4	467	23	.	.	.
cord-259748-x7dq1sy4	468	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	468	2	-	-	HYPH
cord-259748-x7dq1sy4	468	3	STING	sting	NN
cord-259748-x7dq1sy4	468	4	signaling	signaling	NN
cord-259748-x7dq1sy4	468	5	corresponding	correspond	VBG
cord-259748-x7dq1sy4	468	6	to	to	IN
cord-259748-x7dq1sy4	468	7	cytoplasmic	cytoplasmic	JJ
cord-259748-x7dq1sy4	468	8	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	468	9	in	in	IN
cord-259748-x7dq1sy4	468	10	APCs	apc	NNS
cord-259748-x7dq1sy4	468	11	can	can	MD
cord-259748-x7dq1sy4	468	12	boost	boost	VB
cord-259748-x7dq1sy4	468	13	innate	innate	JJ
cord-259748-x7dq1sy4	468	14	and	and	CC
cord-259748-x7dq1sy4	468	15	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	468	16	immunity	immunity	NN
cord-259748-x7dq1sy4	468	17	transiently	transiently	RB
cord-259748-x7dq1sy4	468	18	.	.	.
cord-259748-x7dq1sy4	469	1	In	in	IN
cord-259748-x7dq1sy4	469	2	this	this	DT
cord-259748-x7dq1sy4	469	3	situation	situation	NN
cord-259748-x7dq1sy4	469	4	,	,	,
cord-259748-x7dq1sy4	469	5	the	the	DT
cord-259748-x7dq1sy4	469	6	DNA	dna	NN
cord-259748-x7dq1sy4	469	7	challenge	challenge	NN
cord-259748-x7dq1sy4	469	8	signal	signal	NN
cord-259748-x7dq1sy4	469	9	is	be	VBZ
cord-259748-x7dq1sy4	469	10	limited	limit	VBN
cord-259748-x7dq1sy4	469	11	to	to	IN
cord-259748-x7dq1sy4	469	12	only	only	JJ
cord-259748-x7dq1sy4	469	13	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	469	14	and	and	CC
cord-259748-x7dq1sy4	469	15	DCs	dc	NNS
cord-259748-x7dq1sy4	469	16	.	.	.
cord-259748-x7dq1sy4	470	1	Their	-PRON-	PRP$
cord-259748-x7dq1sy4	470	2	pro	pro	JJ
cord-259748-x7dq1sy4	470	3	-	-	JJ
cord-259748-x7dq1sy4	470	4	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	470	5	and	and	CC
cord-259748-x7dq1sy4	470	6	antigenpresenting	antigenpresenting	NN
cord-259748-x7dq1sy4	470	7	functions	function	NNS
cord-259748-x7dq1sy4	470	8	to	to	IN
cord-259748-x7dq1sy4	470	9	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	470	10	immune	immune	JJ
cord-259748-x7dq1sy4	470	11	cells	cell	NNS
cord-259748-x7dq1sy4	470	12	are	be	VBP
cord-259748-x7dq1sy4	470	13	promoted	promote	VBN
cord-259748-x7dq1sy4	470	14	in	in	IN
cord-259748-x7dq1sy4	470	15	the	the	DT
cord-259748-x7dq1sy4	470	16	short	short	JJ
cord-259748-x7dq1sy4	470	17	-	-	HYPH
cord-259748-x7dq1sy4	470	18	term	term	NN
cord-259748-x7dq1sy4	470	19	.	.	.
cord-259748-x7dq1sy4	471	1	If	if	IN
cord-259748-x7dq1sy4	471	2	the	the	DT
cord-259748-x7dq1sy4	471	3	signal	signal	NN
cord-259748-x7dq1sy4	471	4	spreads	spread	VBZ
cord-259748-x7dq1sy4	471	5	to	to	IN
cord-259748-x7dq1sy4	471	6	other	other	JJ
cord-259748-x7dq1sy4	471	7	bystander	bystander	NN
cord-259748-x7dq1sy4	471	8	cells	cell	NNS
cord-259748-x7dq1sy4	471	9	,	,	,
cord-259748-x7dq1sy4	471	10	such	such	JJ
cord-259748-x7dq1sy4	471	11	as	as	IN
cord-259748-x7dq1sy4	471	12	T	T	NNP
cord-259748-x7dq1sy4	471	13	cells	cell	NNS
cord-259748-x7dq1sy4	471	14	,	,	,
cord-259748-x7dq1sy4	471	15	B	b	NN
cord-259748-x7dq1sy4	471	16	cells	cell	NNS
cord-259748-x7dq1sy4	471	17	,	,	,
cord-259748-x7dq1sy4	471	18	local	local	JJ
cord-259748-x7dq1sy4	471	19	resident	resident	NN
cord-259748-x7dq1sy4	471	20	cells	cell	NNS
cord-259748-x7dq1sy4	471	21	by	by	IN
cord-259748-x7dq1sy4	471	22	means	mean	NNS
cord-259748-x7dq1sy4	471	23	of	of	IN
cord-259748-x7dq1sy4	471	24	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	471	25	transfer	transfer	NN
cord-259748-x7dq1sy4	471	26	,	,	,
cord-259748-x7dq1sy4	471	27	or	or	CC
cord-259748-x7dq1sy4	471	28	just	just	RB
cord-259748-x7dq1sy4	471	29	aberrant	aberrant	JJ
cord-259748-x7dq1sy4	471	30	STING	sting	NN
cord-259748-x7dq1sy4	471	31	activation	activation	NN
cord-259748-x7dq1sy4	471	32	by	by	IN
cord-259748-x7dq1sy4	471	33	GOF	GOF	NNP
cord-259748-x7dq1sy4	471	34	,	,	,
cord-259748-x7dq1sy4	471	35	it	-PRON-	PRP
cord-259748-x7dq1sy4	471	36	causes	cause	VBZ
cord-259748-x7dq1sy4	471	37	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	471	38	in	in	IN
cord-259748-x7dq1sy4	471	39	bystander	bystander	NN
cord-259748-x7dq1sy4	471	40	cells	cell	NNS
cord-259748-x7dq1sy4	471	41	or	or	CC
cord-259748-x7dq1sy4	471	42	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	471	43	immune	immune	JJ
cord-259748-x7dq1sy4	471	44	cells	cell	NNS
cord-259748-x7dq1sy4	471	45	and	and	CC
cord-259748-x7dq1sy4	471	46	immune	immune	JJ
cord-259748-x7dq1sy4	471	47	tolerance	tolerance	NN
cord-259748-x7dq1sy4	471	48	in	in	IN
cord-259748-x7dq1sy4	471	49	the	the	DT
cord-259748-x7dq1sy4	471	50	long	long	JJ
cord-259748-x7dq1sy4	471	51	-	-	HYPH
cord-259748-x7dq1sy4	471	52	term	term	NN
cord-259748-x7dq1sy4	471	53	.	.	.
cord-259748-x7dq1sy4	472	1	Therefore	therefore	RB
cord-259748-x7dq1sy4	472	2	,	,	,
cord-259748-x7dq1sy4	472	3	it	-PRON-	PRP
cord-259748-x7dq1sy4	472	4	is	be	VBZ
cord-259748-x7dq1sy4	472	5	reasonable	reasonable	JJ
cord-259748-x7dq1sy4	472	6	to	to	TO
cord-259748-x7dq1sy4	472	7	conclude	conclude	VB
cord-259748-x7dq1sy4	472	8	that	that	IN
cord-259748-x7dq1sy4	472	9	the	the	DT
cord-259748-x7dq1sy4	472	10	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	472	11	function	function	NN
cord-259748-x7dq1sy4	472	12	of	of	IN
cord-259748-x7dq1sy4	472	13	the	the	DT
cord-259748-x7dq1sy4	472	14	cGAS	cgas	JJ
cord-259748-x7dq1sy4	472	15	-	-	HYPH
cord-259748-x7dq1sy4	472	16	STING	sting	NN
cord-259748-x7dq1sy4	472	17	pathway	pathway	NN
cord-259748-x7dq1sy4	472	18	is	be	VBZ
cord-259748-x7dq1sy4	472	19	essential	essential	JJ
cord-259748-x7dq1sy4	472	20	for	for	IN
cord-259748-x7dq1sy4	472	21	the	the	DT
cord-259748-x7dq1sy4	472	22	innate	innate	JJ
cord-259748-x7dq1sy4	472	23	immune	immune	JJ
cord-259748-x7dq1sy4	472	24	system	system	NN
cord-259748-x7dq1sy4	472	25	responses	response	NNS
cord-259748-x7dq1sy4	472	26	of	of	IN
cord-259748-x7dq1sy4	472	27	the	the	DT
cord-259748-x7dq1sy4	472	28	host	host	NN
cord-259748-x7dq1sy4	472	29	immediately	immediately	RB
cord-259748-x7dq1sy4	472	30	after	after	IN
cord-259748-x7dq1sy4	472	31	pathogen	pathogen	NN
cord-259748-x7dq1sy4	472	32	invasion	invasion	NN
cord-259748-x7dq1sy4	472	33	or	or	CC
cord-259748-x7dq1sy4	472	34	abnormal	abnormal	JJ
cord-259748-x7dq1sy4	472	35	cell	cell	NN
cord-259748-x7dq1sy4	472	36	appearing	appear	VBG
cord-259748-x7dq1sy4	472	37	.	.	.
cord-259748-x7dq1sy4	473	1	Once	once	IN
cord-259748-x7dq1sy4	473	2	the	the	DT
cord-259748-x7dq1sy4	473	3	challenge	challenge	NN
cord-259748-x7dq1sy4	473	4	persists	persist	VBZ
cord-259748-x7dq1sy4	473	5	,	,	,
cord-259748-x7dq1sy4	473	6	the	the	DT
cord-259748-x7dq1sy4	473	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	473	8	-	-	HYPH
cord-259748-x7dq1sy4	473	9	STING	sting	NN
cord-259748-x7dq1sy4	473	10	pathway	pathway	NN
cord-259748-x7dq1sy4	473	11	controls	control	VBZ
cord-259748-x7dq1sy4	473	12	the	the	DT
cord-259748-x7dq1sy4	473	13	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	473	14	immune	immune	JJ
cord-259748-x7dq1sy4	473	15	system	system	NN
cord-259748-x7dq1sy4	473	16	to	to	TO
cord-259748-x7dq1sy4	473	17	avoid	avoid	VB
cord-259748-x7dq1sy4	473	18	chronic	chronic	JJ
cord-259748-x7dq1sy4	473	19	,	,	,
cord-259748-x7dq1sy4	473	20	detrimental	detrimental	JJ
cord-259748-x7dq1sy4	473	21	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	473	22	reactions	reaction	NNS
cord-259748-x7dq1sy4	473	23	or	or	CC
cord-259748-x7dq1sy4	473	24	autoimmune	autoimmune	JJ
cord-259748-x7dq1sy4	473	25	diseases	disease	NNS
cord-259748-x7dq1sy4	473	26	.	.	.
cord-259748-x7dq1sy4	474	1	The	the	DT
cord-259748-x7dq1sy4	474	2	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	474	3	response	response	NN
cord-259748-x7dq1sy4	474	4	exists	exist	VBZ
cord-259748-x7dq1sy4	474	5	universally	universally	RB
cord-259748-x7dq1sy4	474	6	in	in	IN
cord-259748-x7dq1sy4	474	7	almost	almost	RB
cord-259748-x7dq1sy4	474	8	all	all	DT
cord-259748-x7dq1sy4	474	9	physiologic	physiologic	JJ
cord-259748-x7dq1sy4	474	10	and	and	CC
cord-259748-x7dq1sy4	474	11	pathologic	pathologic	JJ
cord-259748-x7dq1sy4	474	12	progressions	progression	NNS
cord-259748-x7dq1sy4	474	13	.	.	.
cord-259748-x7dq1sy4	475	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	475	2	-	-	:
cord-259748-x7dq1sy4	475	3	STING	sting	NN
cord-259748-x7dq1sy4	475	4	is	be	VBZ
cord-259748-x7dq1sy4	475	5	pivotal	pivotal	JJ
cord-259748-x7dq1sy4	475	6	in	in	IN
cord-259748-x7dq1sy4	475	7	modulating	modulate	VBG
cord-259748-x7dq1sy4	475	8	cellular	cellular	JJ
cord-259748-x7dq1sy4	475	9	inflammation	inflammation	NN
cord-259748-x7dq1sy4	475	10	,	,	,
cord-259748-x7dq1sy4	475	11	so	so	CC
cord-259748-x7dq1sy4	475	12	it	-PRON-	PRP
cord-259748-x7dq1sy4	475	13	is	be	VBZ
cord-259748-x7dq1sy4	475	14	promising	promise	VBG
cord-259748-x7dq1sy4	475	15	to	to	TO
cord-259748-x7dq1sy4	475	16	extend	extend	VB
cord-259748-x7dq1sy4	475	17	our	-PRON-	PRP$
cord-259748-x7dq1sy4	475	18	conception	conception	NN
cord-259748-x7dq1sy4	475	19	of	of	IN
cord-259748-x7dq1sy4	475	20	the	the	DT
cord-259748-x7dq1sy4	475	21	cGAS	cgas	JJ
cord-259748-x7dq1sy4	475	22	-	-	HYPH
cord-259748-x7dq1sy4	475	23	STING	sting	NN
cord-259748-x7dq1sy4	475	24	pathway	pathway	NN
cord-259748-x7dq1sy4	475	25	onto	onto	IN
cord-259748-x7dq1sy4	475	26	more	more	JJR
cord-259748-x7dq1sy4	475	27	diseases	disease	NNS
cord-259748-x7dq1sy4	475	28	with	with	IN
cord-259748-x7dq1sy4	475	29	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	475	30	responses	response	NNS
cord-259748-x7dq1sy4	475	31	involved	involve	VBN
cord-259748-x7dq1sy4	475	32	,	,	,
cord-259748-x7dq1sy4	475	33	especially	especially	RB
cord-259748-x7dq1sy4	475	34	CNS	CNS	NNP
cord-259748-x7dq1sy4	475	35	-	-	HYPH
cord-259748-x7dq1sy4	475	36	based	base	VBN
cord-259748-x7dq1sy4	475	37	diseases	disease	NNS
cord-259748-x7dq1sy4	475	38	such	such	JJ
cord-259748-x7dq1sy4	475	39	as	as	IN
cord-259748-x7dq1sy4	475	40	stroke	stroke	NN
cord-259748-x7dq1sy4	475	41	,	,	,
cord-259748-x7dq1sy4	475	42	in	in	IN
cord-259748-x7dq1sy4	475	43	which	which	WDT
cord-259748-x7dq1sy4	475	44	the	the	DT
cord-259748-x7dq1sy4	475	45	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	475	46	reaction	reaction	NN
cord-259748-x7dq1sy4	475	47	exists	exist	VBZ
cord-259748-x7dq1sy4	475	48	but	but	CC
cord-259748-x7dq1sy4	475	49	was	be	VBD
cord-259748-x7dq1sy4	475	50	recognized	recognize	VBN
cord-259748-x7dq1sy4	475	51	less	less	JJR
cord-259748-x7dq1sy4	475	52	.	.	.
cord-259748-x7dq1sy4	476	1	Moreover	moreover	RB
cord-259748-x7dq1sy4	476	2	,	,	,
cord-259748-x7dq1sy4	476	3	for	for	IN
cord-259748-x7dq1sy4	476	4	targeting	target	VBG
cord-259748-x7dq1sy4	476	5	the	the	DT
cord-259748-x7dq1sy4	476	6	cGAS	cgas	JJ
cord-259748-x7dq1sy4	476	7	-	-	HYPH
cord-259748-x7dq1sy4	476	8	STING	sting	NN
cord-259748-x7dq1sy4	476	9	pathway	pathway	NN
cord-259748-x7dq1sy4	476	10	for	for	IN
cord-259748-x7dq1sy4	476	11	therapeutic	therapeutic	JJ
cord-259748-x7dq1sy4	476	12	purposes	purpose	NNS
cord-259748-x7dq1sy4	476	13	,	,	,
cord-259748-x7dq1sy4	476	14	drugs	drug	NNS
cord-259748-x7dq1sy4	476	15	should	should	MD
cord-259748-x7dq1sy4	476	16	be	be	VB
cord-259748-x7dq1sy4	476	17	optimized	optimize	VBN
cord-259748-x7dq1sy4	476	18	to	to	TO
cord-259748-x7dq1sy4	476	19	augment	augment	VB
cord-259748-x7dq1sy4	476	20	the	the	DT
cord-259748-x7dq1sy4	476	21	desirable	desirable	JJ
cord-259748-x7dq1sy4	476	22	effect	effect	NN
cord-259748-x7dq1sy4	476	23	and	and	CC
cord-259748-x7dq1sy4	476	24	prevent	prevent	VB
cord-259748-x7dq1sy4	476	25	its	-PRON-	PRP$
cord-259748-x7dq1sy4	476	26	unwanted	unwanted	JJ
cord-259748-x7dq1sy4	476	27	effects	effect	NNS
cord-259748-x7dq1sy4	476	28	.	.	.
cord-259748-x7dq1sy4	477	1	For	for	IN
cord-259748-x7dq1sy4	477	2	example	example	NN
cord-259748-x7dq1sy4	477	3	,	,	,
cord-259748-x7dq1sy4	477	4	to	to	TO
cord-259748-x7dq1sy4	477	5	eliminate	eliminate	VB
cord-259748-x7dq1sy4	477	6	tumor	tumor	NN
cord-259748-x7dq1sy4	477	7	cells	cell	NNS
cord-259748-x7dq1sy4	477	8	or	or	CC
cord-259748-x7dq1sy4	477	9	infectious	infectious	JJ
cord-259748-x7dq1sy4	477	10	agents	agent	NNS
cord-259748-x7dq1sy4	477	11	,	,	,
cord-259748-x7dq1sy4	477	12	agonists	agonist	NNS
cord-259748-x7dq1sy4	477	13	of	of	IN
cord-259748-x7dq1sy4	477	14	cGAS	cgas	NN
cord-259748-x7dq1sy4	477	15	-	-	:
cord-259748-x7dq1sy4	477	16	STING	sting	NN
cord-259748-x7dq1sy4	477	17	would	would	MD
cord-259748-x7dq1sy4	477	18	be	be	VB
cord-259748-x7dq1sy4	477	19	a	a	DT
cord-259748-x7dq1sy4	477	20	rational	rational	JJ
cord-259748-x7dq1sy4	477	21	option	option	NN
cord-259748-x7dq1sy4	477	22	if	if	IN
cord-259748-x7dq1sy4	477	23	designed	design	VBN
cord-259748-x7dq1sy4	477	24	to	to	TO
cord-259748-x7dq1sy4	477	25	target	target	VB
cord-259748-x7dq1sy4	477	26	APCs	apc	NNS
cord-259748-x7dq1sy4	477	27	exclusively	exclusively	RB
cord-259748-x7dq1sy4	477	28	but	but	CC
cord-259748-x7dq1sy4	477	29	not	not	RB
cord-259748-x7dq1sy4	477	30	T	t	NN
cord-259748-x7dq1sy4	477	31	cells	cell	NNS
cord-259748-x7dq1sy4	477	32	or	or	CC
cord-259748-x7dq1sy4	477	33	B	b	NN
cord-259748-x7dq1sy4	477	34	cells	cell	NNS
cord-259748-x7dq1sy4	477	35	.	.	.
cord-259748-x7dq1sy4	478	1	In	in	IN
cord-259748-x7dq1sy4	478	2	this	this	DT
cord-259748-x7dq1sy4	478	3	scheme	scheme	NN
cord-259748-x7dq1sy4	478	4	,	,	,
cord-259748-x7dq1sy4	478	5	the	the	DT
cord-259748-x7dq1sy4	478	6	antitumor	antitumor	NN
cord-259748-x7dq1sy4	478	7	immune	immune	JJ
cord-259748-x7dq1sy4	478	8	response	response	NN
cord-259748-x7dq1sy4	478	9	is	be	VBZ
cord-259748-x7dq1sy4	478	10	enhanced	enhance	VBN
cord-259748-x7dq1sy4	478	11	while	while	IN
cord-259748-x7dq1sy4	478	12	avoiding	avoid	VBG
cord-259748-x7dq1sy4	478	13	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	478	14	of	of	IN
cord-259748-x7dq1sy4	478	15	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	478	16	immune	immune	JJ
cord-259748-x7dq1sy4	478	17	cells	cell	NNS
cord-259748-x7dq1sy4	478	18	and	and	CC
cord-259748-x7dq1sy4	478	19	infiltration	infiltration	NN
cord-259748-x7dq1sy4	478	20	of	of	IN
cord-259748-x7dq1sy4	478	21	immune	immune	JJ
cord-259748-x7dq1sy4	478	22	suppressor	suppressor	NN
cord-259748-x7dq1sy4	478	23	cells	cell	NNS
cord-259748-x7dq1sy4	478	24	.	.	.
cord-259748-x7dq1sy4	479	1	Also	also	RB
cord-259748-x7dq1sy4	479	2	,	,	,
cord-259748-x7dq1sy4	479	3	most	most	JJS
cord-259748-x7dq1sy4	479	4	research	research	NN
cord-259748-x7dq1sy4	479	5	on	on	IN
cord-259748-x7dq1sy4	479	6	the	the	DT
cord-259748-x7dq1sy4	479	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	479	8	-	-	HYPH
cord-259748-x7dq1sy4	479	9	STING	sting	NN
cord-259748-x7dq1sy4	479	10	pathway	pathway	NN
cord-259748-x7dq1sy4	479	11	has	have	VBZ
cord-259748-x7dq1sy4	479	12	focused	focus	VBN
cord-259748-x7dq1sy4	479	13	on	on	IN
cord-259748-x7dq1sy4	479	14	its	-PRON-	PRP$
cord-259748-x7dq1sy4	479	15	IFN	IFN	NNP
cord-259748-x7dq1sy4	479	16	-	-	HYPH
cord-259748-x7dq1sy4	479	17	expressing	express	VBG
cord-259748-x7dq1sy4	479	18	role	role	NN
cord-259748-x7dq1sy4	479	19	but	but	CC
cord-259748-x7dq1sy4	479	20	overlooked	overlook	VBD
cord-259748-x7dq1sy4	479	21	autophagy	autophagy	NN
cord-259748-x7dq1sy4	479	22	and	and	CC
cord-259748-x7dq1sy4	479	23	cell	cell	NN
cord-259748-x7dq1sy4	479	24	-	-	HYPH
cord-259748-x7dq1sy4	479	25	death	death	NN
cord-259748-x7dq1sy4	479	26	roles	role	NNS
cord-259748-x7dq1sy4	479	27	,	,	,
cord-259748-x7dq1sy4	479	28	which	which	WDT
cord-259748-x7dq1sy4	479	29	are	be	VBP
cord-259748-x7dq1sy4	479	30	also	also	RB
cord-259748-x7dq1sy4	479	31	main	main	JJ
cord-259748-x7dq1sy4	479	32	downstream	downstream	JJ
cord-259748-x7dq1sy4	479	33	signaling	signaling	NN
cord-259748-x7dq1sy4	479	34	of	of	IN
cord-259748-x7dq1sy4	479	35	the	the	DT
cord-259748-x7dq1sy4	479	36	pathway	pathway	NN
cord-259748-x7dq1sy4	479	37	.	.	.
cord-259748-x7dq1sy4	480	1	Therefore	therefore	RB
cord-259748-x7dq1sy4	480	2	,	,	,
cord-259748-x7dq1sy4	480	3	some	some	DT
cord-259748-x7dq1sy4	480	4	drugs	drug	NNS
cord-259748-x7dq1sy4	480	5	,	,	,
cord-259748-x7dq1sy4	480	6	such	such	JJ
cord-259748-x7dq1sy4	480	7	as	as	IN
cord-259748-x7dq1sy4	480	8	emricasan	emricasan	NNP
cord-259748-x7dq1sy4	480	9	,	,	,
cord-259748-x7dq1sy4	480	10	are	be	VBP
cord-259748-x7dq1sy4	480	11	potential	potential	JJ
cord-259748-x7dq1sy4	480	12	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	480	13	inhibitors	inhibitor	NNS
cord-259748-x7dq1sy4	480	14	that	that	WDT
cord-259748-x7dq1sy4	480	15	may	may	MD
cord-259748-x7dq1sy4	480	16	have	have	VB
cord-259748-x7dq1sy4	480	17	a	a	DT
cord-259748-x7dq1sy4	480	18	complementary	complementary	JJ
cord-259748-x7dq1sy4	480	19	effect	effect	NN
cord-259748-x7dq1sy4	480	20	on	on	IN
cord-259748-x7dq1sy4	480	21	ameliorating	ameliorate	VBG
cord-259748-x7dq1sy4	480	22	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	480	23	of	of	IN
cord-259748-x7dq1sy4	480	24	blood	blood	NN
cord-259748-x7dq1sy4	480	25	-	-	HYPH
cord-259748-x7dq1sy4	480	26	vessel	vessel	NN
cord-259748-x7dq1sy4	480	27	endothelial	endothelial	JJ
cord-259748-x7dq1sy4	480	28	cells	cell	NNS
cord-259748-x7dq1sy4	480	29	or	or	CC
cord-259748-x7dq1sy4	480	30	bronchial	bronchial	JJ
cord-259748-x7dq1sy4	480	31	epithelial	epithelial	JJ
cord-259748-x7dq1sy4	480	32	cells	cell	NNS
cord-259748-x7dq1sy4	480	33	,	,	,
cord-259748-x7dq1sy4	480	34	and	and	CC
cord-259748-x7dq1sy4	480	35	lymphopenia	lymphopenia	NNP
cord-259748-x7dq1sy4	480	36	,	,	,
cord-259748-x7dq1sy4	480	37	in	in	IN
cord-259748-x7dq1sy4	480	38	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	480	39	.	.	.
cord-259748-x7dq1sy4	481	1	Until	until	IN
cord-259748-x7dq1sy4	481	2	now	now	RB
cord-259748-x7dq1sy4	481	3	,	,	,
cord-259748-x7dq1sy4	481	4	studies	study	NNS
cord-259748-x7dq1sy4	481	5	of	of	IN
cord-259748-x7dq1sy4	481	6	the	the	DT
cord-259748-x7dq1sy4	481	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	481	8	-	-	HYPH
cord-259748-x7dq1sy4	481	9	STING	sting	NN
cord-259748-x7dq1sy4	481	10	pathway	pathway	NN
cord-259748-x7dq1sy4	481	11	have	have	VBP
cord-259748-x7dq1sy4	481	12	been	be	VBN
cord-259748-x7dq1sy4	481	13	done	do	VBN
cord-259748-x7dq1sy4	481	14	mainly	mainly	RB
cord-259748-x7dq1sy4	481	15	in	in	IN
cord-259748-x7dq1sy4	481	16	the	the	DT
cord-259748-x7dq1sy4	481	17	laboratory	laboratory	NN
cord-259748-x7dq1sy4	481	18	but	but	CC
cord-259748-x7dq1sy4	481	19	it	-PRON-	PRP
cord-259748-x7dq1sy4	481	20	has	have	VBZ
cord-259748-x7dq1sy4	481	21	large	large	JJ
cord-259748-x7dq1sy4	481	22	space	space	NN
cord-259748-x7dq1sy4	481	23	to	to	TO
cord-259748-x7dq1sy4	481	24	be	be	VB
cord-259748-x7dq1sy4	481	25	explored	explore	VBN
cord-259748-x7dq1sy4	481	26	in	in	IN
cord-259748-x7dq1sy4	481	27	clinical	clinical	JJ
cord-259748-x7dq1sy4	481	28	or	or	CC
cord-259748-x7dq1sy4	481	29	translational	translational	JJ
cord-259748-x7dq1sy4	481	30	fields	field	NNS
cord-259748-x7dq1sy4	481	31	.	.	.
cord-259748-x7dq1sy4	482	1	Additionally	additionally	RB
cord-259748-x7dq1sy4	482	2	More	More	JJR
cord-259748-x7dq1sy4	482	3	PRRs	prr	NNS
cord-259748-x7dq1sy4	482	4	and	and	CC
cord-259748-x7dq1sy4	482	5	cellular	cellular	JJ
cord-259748-x7dq1sy4	482	6	immune	immune	JJ
cord-259748-x7dq1sy4	482	7	-	-	HYPH
cord-259748-x7dq1sy4	482	8	surveillance	surveillance	NN
cord-259748-x7dq1sy4	482	9	pathways	pathway	NNS
cord-259748-x7dq1sy4	482	10	may	may	MD
cord-259748-x7dq1sy4	482	11	remain	remain	VB
cord-259748-x7dq1sy4	482	12	to	to	TO
cord-259748-x7dq1sy4	482	13	be	be	VB
cord-259748-x7dq1sy4	482	14	discovered	discover	VBN
cord-259748-x7dq1sy4	482	15	to	to	TO
cord-259748-x7dq1sy4	482	16	piece	piece	VB
cord-259748-x7dq1sy4	482	17	together	together	RB
cord-259748-x7dq1sy4	482	18	the	the	DT
cord-259748-x7dq1sy4	482	19	molecular	molecular	JJ
cord-259748-x7dq1sy4	482	20	puzzles	puzzle	NNS
cord-259748-x7dq1sy4	482	21	of	of	IN
cord-259748-x7dq1sy4	482	22	the	the	DT
cord-259748-x7dq1sy4	482	23	cell	cell	NN
cord-259748-x7dq1sy4	482	24	.	.	.
cord-259748-x7dq1sy4	483	1	DW	DW	NNP
cord-259748-x7dq1sy4	483	2	drafted	draft	VBD
cord-259748-x7dq1sy4	483	3	the	the	DT
cord-259748-x7dq1sy4	483	4	manuscript	manuscript	NN
cord-259748-x7dq1sy4	483	5	and	and	CC
cord-259748-x7dq1sy4	483	6	drew	draw	VBD
cord-259748-x7dq1sy4	483	7	the	the	DT
cord-259748-x7dq1sy4	483	8	figures	figure	NNS
cord-259748-x7dq1sy4	483	9	.	.	.
cord-259748-x7dq1sy4	484	1	WJ	WJ	NNP
cord-259748-x7dq1sy4	484	2	and	and	CC
cord-259748-x7dq1sy4	484	3	JH	JH	NNP
cord-259748-x7dq1sy4	484	4	conceived	conceive	VBD
cord-259748-x7dq1sy4	484	5	and	and	CC
cord-259748-x7dq1sy4	484	6	revised	revise	VBD
cord-259748-x7dq1sy4	484	7	the	the	DT
cord-259748-x7dq1sy4	484	8	review	review	NN
cord-259748-x7dq1sy4	484	9	.	.	.
cord-259748-x7dq1sy4	485	1	Frontiers	frontier	NNS
cord-259748-x7dq1sy4	485	2	in	in	IN
cord-259748-x7dq1sy4	485	3	Immunology	Immunology	NNP
cord-259748-x7dq1sy4	485	4	|	|	NNP
cord-259748-x7dq1sy4	485	5	www.frontiersin.org	www.frontiersin.org	IN
cord-259748-x7dq1sy4	485	6	Recognition	Recognition	NNP
cord-259748-x7dq1sy4	485	7	of	of	IN
cord-259748-x7dq1sy4	485	8	endogenous	endogenous	JJ
cord-259748-x7dq1sy4	485	9	nucleic	nucleic	JJ
cord-259748-x7dq1sy4	485	10	acids	acid	NNS
cord-259748-x7dq1sy4	485	11	by	by	IN
cord-259748-x7dq1sy4	485	12	the	the	DT
cord-259748-x7dq1sy4	485	13	innate	innate	JJ
cord-259748-x7dq1sy4	485	14	immune	immune	JJ
cord-259748-x7dq1sy4	485	15	system	system	NN
cord-259748-x7dq1sy4	485	16	STING	sting	NN
cord-259748-x7dq1sy4	485	17	is	be	VBZ
cord-259748-x7dq1sy4	485	18	an	an	DT
cord-259748-x7dq1sy4	485	19	endoplasmic	endoplasmic	NN
cord-259748-x7dq1sy4	485	20	reticulum	reticulum	NN
cord-259748-x7dq1sy4	485	21	adaptor	adaptor	NN
cord-259748-x7dq1sy4	485	22	that	that	WDT
cord-259748-x7dq1sy4	485	23	facilitates	facilitate	VBZ
cord-259748-x7dq1sy4	485	24	innate	innate	JJ
cord-259748-x7dq1sy4	485	25	immune	immune	NN
cord-259748-x7dq1sy4	485	26	signalling	signal	VBG
cord-259748-x7dq1sy4	485	27	The	the	DT
cord-259748-x7dq1sy4	485	28	adaptor	adaptor	NN
cord-259748-x7dq1sy4	485	29	protein	protein	NN
cord-259748-x7dq1sy4	485	30	MITA	MITA	NNP
cord-259748-x7dq1sy4	485	31	links	link	VBZ
cord-259748-x7dq1sy4	485	32	virus	virus	NN
cord-259748-x7dq1sy4	485	33	-	-	HYPH
cord-259748-x7dq1sy4	485	34	sensing	sense	VBG
cord-259748-x7dq1sy4	485	35	receptors	receptor	NNS
cord-259748-x7dq1sy4	485	36	to	to	IN
cord-259748-x7dq1sy4	485	37	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	485	38	transcription	transcription	NN
cord-259748-x7dq1sy4	485	39	factor	factor	NN
cord-259748-x7dq1sy4	485	40	activation	activation	NN
cord-259748-x7dq1sy4	485	41	an	an	DT
cord-259748-x7dq1sy4	485	42	endoplasmic	endoplasmic	NN
cord-259748-x7dq1sy4	485	43	reticulum	reticulum	NN
cord-259748-x7dq1sy4	485	44	IFN	IFN	NNP
cord-259748-x7dq1sy4	485	45	stimulator	stimulator	NN
cord-259748-x7dq1sy4	485	46	,	,	,
cord-259748-x7dq1sy4	485	47	activates	activate	VBZ
cord-259748-x7dq1sy4	485	48	innate	innate	JJ
cord-259748-x7dq1sy4	485	49	immune	immune	NN
cord-259748-x7dq1sy4	485	50	signaling	signal	VBG
cord-259748-x7dq1sy4	485	51	through	through	IN
cord-259748-x7dq1sy4	485	52	dimerization	dimerization	NN
cord-259748-x7dq1sy4	485	53	C	c	NN
cord-259748-x7dq1sy4	485	54	-	-	HYPH
cord-259748-x7dq1sy4	485	55	di	di	NNP
cord-259748-x7dq1sy4	485	56	-	-	HYPH
cord-259748-x7dq1sy4	485	57	AMP	amp	NN
cord-259748-x7dq1sy4	485	58	secreted	secrete	VBN
cord-259748-x7dq1sy4	485	59	by	by	IN
cord-259748-x7dq1sy4	485	60	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	485	61	Listeria	Listeria	NNP
cord-259748-x7dq1sy4	485	62	monocytogenes	monocytogenes	NNP
cord-259748-x7dq1sy4	485	63	activates	activate	VBZ
cord-259748-x7dq1sy4	485	64	a	a	DT
cord-259748-x7dq1sy4	485	65	host	host	NN
cord-259748-x7dq1sy4	485	66	type	type	NN
cord-259748-x7dq1sy4	485	67	I	-PRON-	PRP
cord-259748-x7dq1sy4	485	68	interferon	interferon	VBD
cord-259748-x7dq1sy4	485	69	response	response	NN
cord-259748-x7dq1sy4	485	70	STING	sting	NN
cord-259748-x7dq1sy4	485	71	is	be	VBZ
cord-259748-x7dq1sy4	485	72	a	a	DT
cord-259748-x7dq1sy4	485	73	direct	direct	JJ
cord-259748-x7dq1sy4	485	74	innate	innate	JJ
cord-259748-x7dq1sy4	485	75	immune	immune	JJ
cord-259748-x7dq1sy4	485	76	sensor	sensor	NN
cord-259748-x7dq1sy4	485	77	of	of	IN
cord-259748-x7dq1sy4	485	78	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	485	79	di	di	FW
cord-259748-x7dq1sy4	485	80	-	-	HYPH
cord-259748-x7dq1sy4	485	81	GMP	GMP	NNP
cord-259748-x7dq1sy4	485	82	IFI16	IFI16	NNP
cord-259748-x7dq1sy4	485	83	is	be	VBZ
cord-259748-x7dq1sy4	485	84	an	an	DT
cord-259748-x7dq1sy4	485	85	innate	innate	JJ
cord-259748-x7dq1sy4	485	86	immune	immune	JJ
cord-259748-x7dq1sy4	485	87	sensor	sensor	NN
cord-259748-x7dq1sy4	485	88	for	for	IN
cord-259748-x7dq1sy4	485	89	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	485	90	DNA	dna	NN
cord-259748-x7dq1sy4	486	1	Cyclic	cyclic	JJ
cord-259748-x7dq1sy4	486	2	GMP	GMP	NNP
cord-259748-x7dq1sy4	486	3	-	-	HYPH
cord-259748-x7dq1sy4	486	4	AMP	AMP	NNP
cord-259748-x7dq1sy4	486	5	synthase	synthase	NN
cord-259748-x7dq1sy4	486	6	is	be	VBZ
cord-259748-x7dq1sy4	486	7	a	a	DT
cord-259748-x7dq1sy4	486	8	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	486	9	DNA	dna	NN
cord-259748-x7dq1sy4	486	10	sensor	sensor	NN
cord-259748-x7dq1sy4	486	11	that	that	WDT
cord-259748-x7dq1sy4	486	12	activates	activate	VBZ
cord-259748-x7dq1sy4	486	13	the	the	DT
cord-259748-x7dq1sy4	486	14	type	type	NN
cord-259748-x7dq1sy4	487	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	487	2	interferon	interferon	VBD
cord-259748-x7dq1sy4	487	3	pathway	pathway	VBP
cord-259748-x7dq1sy4	487	4	Pivotal	pivotal	JJ
cord-259748-x7dq1sy4	487	5	roles	role	NNS
cord-259748-x7dq1sy4	487	6	of	of	IN
cord-259748-x7dq1sy4	487	7	cGAS	cgas	NN
cord-259748-x7dq1sy4	487	8	-	-	HYPH
cord-259748-x7dq1sy4	487	9	cGAMP	cgamp	NN
cord-259748-x7dq1sy4	487	10	signaling	signal	VBG
cord-259748-x7dq1sy4	487	11	in	in	IN
cord-259748-x7dq1sy4	487	12	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	487	13	defense	defense	NN
cord-259748-x7dq1sy4	487	14	and	and	CC
cord-259748-x7dq1sy4	487	15	immune	immune	JJ
cord-259748-x7dq1sy4	487	16	adjuvant	adjuvant	NN
cord-259748-x7dq1sy4	487	17	effects	effect	NNS
cord-259748-x7dq1sy4	487	18	An	an	DT
cord-259748-x7dq1sy4	487	19	expression	expression	NN
cord-259748-x7dq1sy4	487	20	atlas	atlas	NN
cord-259748-x7dq1sy4	487	21	of	of	IN
cord-259748-x7dq1sy4	487	22	human	human	JJ
cord-259748-x7dq1sy4	487	23	primary	primary	JJ
cord-259748-x7dq1sy4	487	24	cells	cell	NNS
cord-259748-x7dq1sy4	487	25	:	:	:
cord-259748-x7dq1sy4	487	26	inference	inference	NN
cord-259748-x7dq1sy4	487	27	of	of	IN
cord-259748-x7dq1sy4	487	28	gene	gene	NN
cord-259748-x7dq1sy4	487	29	function	function	NN
cord-259748-x7dq1sy4	487	30	from	from	IN
cord-259748-x7dq1sy4	487	31	coexpression	coexpression	NN
cord-259748-x7dq1sy4	487	32	networks	network	NNS
cord-259748-x7dq1sy4	488	1	Bacterial	bacterial	JJ
cord-259748-x7dq1sy4	488	2	cGAS	cgas	NN
cord-259748-x7dq1sy4	488	3	-	-	HYPH
cord-259748-x7dq1sy4	488	4	like	like	JJ
cord-259748-x7dq1sy4	488	5	enzymes	enzyme	NNS
cord-259748-x7dq1sy4	488	6	synthesize	synthesize	VBP
cord-259748-x7dq1sy4	488	7	diverse	diverse	JJ
cord-259748-x7dq1sy4	488	8	nucleotide	nucleotide	JJ
cord-259748-x7dq1sy4	488	9	signals	signal	NNS
cord-259748-x7dq1sy4	488	10	Structural	structural	JJ
cord-259748-x7dq1sy4	488	11	mechanism	mechanism	NN
cord-259748-x7dq1sy4	488	12	of	of	IN
cord-259748-x7dq1sy4	488	13	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	488	14	DNA	dna	NN
cord-259748-x7dq1sy4	488	15	sensing	sensing	NN
cord-259748-x7dq1sy4	488	16	by	by	IN
cord-259748-x7dq1sy4	488	17	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	488	18	Structure	Structure	NNP
cord-259748-x7dq1sy4	488	19	of	of	IN
cord-259748-x7dq1sy4	488	20	human	human	JJ
cord-259748-x7dq1sy4	488	21	cGAS	cgas	NN
cord-259748-x7dq1sy4	488	22	reveals	reveal	VBZ
cord-259748-x7dq1sy4	488	23	a	a	DT
cord-259748-x7dq1sy4	488	24	conserved	conserved	JJ
cord-259748-x7dq1sy4	488	25	family	family	NN
cord-259748-x7dq1sy4	488	26	of	of	IN
cord-259748-x7dq1sy4	488	27	second	second	JJ
cord-259748-x7dq1sy4	488	28	-	-	HYPH
cord-259748-x7dq1sy4	488	29	messenger	messenger	NN
cord-259748-x7dq1sy4	488	30	enzymes	enzyme	NNS
cord-259748-x7dq1sy4	488	31	in	in	IN
cord-259748-x7dq1sy4	488	32	innate	innate	JJ
cord-259748-x7dq1sy4	488	33	immunity	immunity	NN
cord-259748-x7dq1sy4	488	34	Cytosolic	Cytosolic	NNP
cord-259748-x7dq1sy4	488	35	RNA	RNA	NNP
cord-259748-x7dq1sy4	488	36	:	:	:
cord-259748-x7dq1sy4	488	37	DNA	dna	NN
cord-259748-x7dq1sy4	488	38	hybrids	hybrid	NNS
cord-259748-x7dq1sy4	488	39	activate	activate	VBP
cord-259748-x7dq1sy4	488	40	the	the	DT
cord-259748-x7dq1sy4	488	41	cGAS	cgas	JJ
cord-259748-x7dq1sy4	488	42	-	-	HYPH
cord-259748-x7dq1sy4	488	43	STING	sting	NN
cord-259748-x7dq1sy4	488	44	axis	axis	NN
cord-259748-x7dq1sy4	488	45	Sequence	sequence	NN
cord-259748-x7dq1sy4	488	46	-	-	HYPH
cord-259748-x7dq1sy4	488	47	specific	specific	JJ
cord-259748-x7dq1sy4	488	48	activation	activation	NN
cord-259748-x7dq1sy4	488	49	of	of	IN
cord-259748-x7dq1sy4	488	50	the	the	DT
cord-259748-x7dq1sy4	488	51	DNA	dna	NN
cord-259748-x7dq1sy4	488	52	sensor	sensor	NN
cord-259748-x7dq1sy4	488	53	cGAS	cgas	NN
cord-259748-x7dq1sy4	488	54	by	by	IN
cord-259748-x7dq1sy4	488	55	Y	y	NN
cord-259748-x7dq1sy4	488	56	-	-	HYPH
cord-259748-x7dq1sy4	488	57	form	form	NN
cord-259748-x7dq1sy4	488	58	DNA	dna	NN
cord-259748-x7dq1sy4	488	59	structures	structure	NNS
cord-259748-x7dq1sy4	488	60	as	as	IN
cord-259748-x7dq1sy4	488	61	found	find	VBN
cord-259748-x7dq1sy4	488	62	in	in	IN
cord-259748-x7dq1sy4	488	63	primary	primary	JJ
cord-259748-x7dq1sy4	488	64	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	488	65	cDNA	cdna	NN
cord-259748-x7dq1sy4	488	66	cGAS	cgas	NN
cord-259748-x7dq1sy4	489	1	produces	produce	VBZ
cord-259748-x7dq1sy4	489	2	a	a	DT
cord-259748-x7dq1sy4	489	3	2	2	CD
cord-259748-x7dq1sy4	489	4	-5	-5	CD
cord-259748-x7dq1sy4	489	5	-linked	-linked	JJ
cord-259748-x7dq1sy4	489	6	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	489	7	dinucleotide	dinucleotide	NN
cord-259748-x7dq1sy4	489	8	second	second	JJ
cord-259748-x7dq1sy4	489	9	messenger	messenger	NN
cord-259748-x7dq1sy4	489	10	that	that	WDT
cord-259748-x7dq1sy4	489	11	activates	activate	VBZ
cord-259748-x7dq1sy4	489	12	STING	STING	NNP
cord-259748-x7dq1sy4	490	1	The	the	DT
cord-259748-x7dq1sy4	490	2	catalytic	catalytic	JJ
cord-259748-x7dq1sy4	490	3	mechanism	mechanism	NN
cord-259748-x7dq1sy4	490	4	of	of	IN
cord-259748-x7dq1sy4	490	5	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	490	6	GMP	GMP	NNP
cord-259748-x7dq1sy4	490	7	-	-	HYPH
cord-259748-x7dq1sy4	490	8	AMP	AMP	NNP
cord-259748-x7dq1sy4	490	9	synthase	synthase	NN
cord-259748-x7dq1sy4	490	10	(	(	-LRB-
cord-259748-x7dq1sy4	490	11	cGAS	cgas	NN
cord-259748-x7dq1sy4	490	12	)	)	-RRB-
cord-259748-x7dq1sy4	490	13	and	and	CC
cord-259748-x7dq1sy4	490	14	implications	implication	NNS
cord-259748-x7dq1sy4	490	15	for	for	IN
cord-259748-x7dq1sy4	490	16	innate	innate	JJ
cord-259748-x7dq1sy4	490	17	immunity	immunity	NN
cord-259748-x7dq1sy4	490	18	and	and	CC
cord-259748-x7dq1sy4	490	19	inhibition	inhibition	NN
cord-259748-x7dq1sy4	491	1	The	the	DT
cord-259748-x7dq1sy4	491	2	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	491	3	DNA	dna	NN
cord-259748-x7dq1sy4	491	4	sensor	sensor	NN
cord-259748-x7dq1sy4	491	5	cGAS	cgas	NN
cord-259748-x7dq1sy4	491	6	forms	form	VBZ
cord-259748-x7dq1sy4	491	7	an	an	DT
cord-259748-x7dq1sy4	491	8	oligomeric	oligomeric	JJ
cord-259748-x7dq1sy4	491	9	complex	complex	NN
cord-259748-x7dq1sy4	491	10	with	with	IN
cord-259748-x7dq1sy4	491	11	DNA	dna	NN
cord-259748-x7dq1sy4	491	12	and	and	CC
cord-259748-x7dq1sy4	491	13	undergoes	undergo	VBZ
cord-259748-x7dq1sy4	491	14	switch	switch	VB
cord-259748-x7dq1sy4	491	15	-	-	HYPH
cord-259748-x7dq1sy4	491	16	like	like	JJ
cord-259748-x7dq1sy4	491	17	conformational	conformational	JJ
cord-259748-x7dq1sy4	491	18	changes	change	NNS
cord-259748-x7dq1sy4	491	19	in	in	IN
cord-259748-x7dq1sy4	491	20	the	the	DT
cord-259748-x7dq1sy4	491	21	activation	activation	NN
cord-259748-x7dq1sy4	491	22	loop	loop	NN
cord-259748-x7dq1sy4	492	1	Cyclic	cyclic	JJ
cord-259748-x7dq1sy4	492	2	GMP	GMP	NNP
cord-259748-x7dq1sy4	492	3	-	-	HYPH
cord-259748-x7dq1sy4	492	4	AMP	AMP	NNP
cord-259748-x7dq1sy4	492	5	synthase	synthase	NN
cord-259748-x7dq1sy4	492	6	is	be	VBZ
cord-259748-x7dq1sy4	492	7	activated	activate	VBN
cord-259748-x7dq1sy4	492	8	by	by	IN
cord-259748-x7dq1sy4	492	9	double	double	RB
cord-259748-x7dq1sy4	492	10	-	-	HYPH
cord-259748-x7dq1sy4	492	11	stranded	strand	VBN
cord-259748-x7dq1sy4	492	12	DNA	dna	NN
cord-259748-x7dq1sy4	492	13	-	-	HYPH
cord-259748-x7dq1sy4	492	14	induced	induce	VBN
cord-259748-x7dq1sy4	492	15	oligomerization	oligomerization	NN
cord-259748-x7dq1sy4	492	16	Structure	structure	NN
cord-259748-x7dq1sy4	492	17	of	of	IN
cord-259748-x7dq1sy4	492	18	the	the	DT
cord-259748-x7dq1sy4	492	19	human	human	JJ
cord-259748-x7dq1sy4	492	20	cGAS	cgas	JJ
cord-259748-x7dq1sy4	492	21	-	-	HYPH
cord-259748-x7dq1sy4	492	22	DNA	dna	NN
cord-259748-x7dq1sy4	492	23	complex	complex	NN
cord-259748-x7dq1sy4	492	24	reveals	reveal	VBZ
cord-259748-x7dq1sy4	492	25	enhanced	enhance	VBN
cord-259748-x7dq1sy4	492	26	control	control	NN
cord-259748-x7dq1sy4	492	27	of	of	IN
cord-259748-x7dq1sy4	492	28	immune	immune	JJ
cord-259748-x7dq1sy4	492	29	surveillance	surveillance	NN
cord-259748-x7dq1sy4	492	30	cGAS	cgas	NN
cord-259748-x7dq1sy4	492	31	senses	sense	VBZ
cord-259748-x7dq1sy4	492	32	long	long	RB
cord-259748-x7dq1sy4	492	33	and	and	CC
cord-259748-x7dq1sy4	492	34	HMGB	HMGB	NNP
cord-259748-x7dq1sy4	492	35	/	/	SYM
cord-259748-x7dq1sy4	492	36	TFAM	TFAM	NNP
cord-259748-x7dq1sy4	492	37	-	-	HYPH
cord-259748-x7dq1sy4	492	38	bound	bind	VBN
cord-259748-x7dq1sy4	492	39	U	u	NN
cord-259748-x7dq1sy4	492	40	-	-	HYPH
cord-259748-x7dq1sy4	492	41	turn	turn	NN
cord-259748-x7dq1sy4	492	42	DNA	dna	NN
cord-259748-x7dq1sy4	492	43	by	by	IN
cord-259748-x7dq1sy4	492	44	forming	form	VBG
cord-259748-x7dq1sy4	492	45	protein	protein	NN
cord-259748-x7dq1sy4	492	46	-	-	HYPH
cord-259748-x7dq1sy4	492	47	DNA	dna	NN
cord-259748-x7dq1sy4	492	48	ladders	ladder	NNS
cord-259748-x7dq1sy4	493	1	DNA	dna	NN
cord-259748-x7dq1sy4	493	2	-	-	HYPH
cord-259748-x7dq1sy4	493	3	induced	induce	VBN
cord-259748-x7dq1sy4	493	4	liquid	liquid	NN
cord-259748-x7dq1sy4	493	5	phase	phase	NN
cord-259748-x7dq1sy4	493	6	condensation	condensation	NN
cord-259748-x7dq1sy4	493	7	of	of	IN
cord-259748-x7dq1sy4	493	8	cGAS	cgas	NN
cord-259748-x7dq1sy4	493	9	activates	activate	VBZ
cord-259748-x7dq1sy4	493	10	innate	innate	JJ
cord-259748-x7dq1sy4	493	11	immune	immune	NN
cord-259748-x7dq1sy4	494	1	signaling	signal	VBG
cord-259748-x7dq1sy4	494	2	Human	human	JJ
cord-259748-x7dq1sy4	494	3	cGAS	cgas	JJ
cord-259748-x7dq1sy4	494	4	catalytic	catalytic	JJ
cord-259748-x7dq1sy4	494	5	domain	domain	NN
cord-259748-x7dq1sy4	494	6	has	have	VBZ
cord-259748-x7dq1sy4	494	7	an	an	DT
cord-259748-x7dq1sy4	494	8	additional	additional	JJ
cord-259748-x7dq1sy4	494	9	DNA	dna	NN
cord-259748-x7dq1sy4	494	10	-	-	HYPH
cord-259748-x7dq1sy4	494	11	binding	bind	VBG
cord-259748-x7dq1sy4	494	12	interface	interface	NN
cord-259748-x7dq1sy4	494	13	that	that	WDT
cord-259748-x7dq1sy4	494	14	Apoptotic	Apoptotic	NNP
cord-259748-x7dq1sy4	494	15	caspases	caspase	NNS
cord-259748-x7dq1sy4	494	16	suppress	suppress	VBP
cord-259748-x7dq1sy4	494	17	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	494	18	-	-	HYPH
cord-259748-x7dq1sy4	494	19	induced	induce	VBN
cord-259748-x7dq1sy4	494	20	STING	sting	NN
cord-259748-x7dq1sy4	494	21	-	-	HYPH
cord-259748-x7dq1sy4	494	22	mediated	mediate	VBN
cord-259748-x7dq1sy4	494	23	type	type	NN
cord-259748-x7dq1sy4	494	24	I	-PRON-	PRP
cord-259748-x7dq1sy4	494	25	IFN	IFN	NNP
cord-259748-x7dq1sy4	494	26	production	production	NN
cord-259748-x7dq1sy4	494	27	Obsessive	obsessive	JJ
cord-259748-x7dq1sy4	494	28	-	-	HYPH
cord-259748-x7dq1sy4	494	29	compulsive	compulsive	JJ
cord-259748-x7dq1sy4	494	30	disorder	disorder	NN
cord-259748-x7dq1sy4	494	31	is	be	VBZ
cord-259748-x7dq1sy4	494	32	associated	associate	VBN
cord-259748-x7dq1sy4	494	33	with	with	IN
cord-259748-x7dq1sy4	494	34	broad	broad	JJ
cord-259748-x7dq1sy4	494	35	impairments	impairment	NNS
cord-259748-x7dq1sy4	494	36	in	in	IN
cord-259748-x7dq1sy4	494	37	executive	executive	JJ
cord-259748-x7dq1sy4	494	38	function	function	NN
cord-259748-x7dq1sy4	494	39	:	:	:
cord-259748-x7dq1sy4	494	40	a	a	DT
cord-259748-x7dq1sy4	494	41	meta	meta	JJ
cord-259748-x7dq1sy4	494	42	-	-	HYPH
cord-259748-x7dq1sy4	494	43	analysis	analysis	NN
cord-259748-x7dq1sy4	494	44	Ribonuclease	Ribonuclease	NNP
cord-259748-x7dq1sy4	494	45	H2	H2	NNP
cord-259748-x7dq1sy4	494	46	mutations	mutation	NNS
cord-259748-x7dq1sy4	494	47	induce	induce	VBP
cord-259748-x7dq1sy4	494	48	a	a	DT
cord-259748-x7dq1sy4	494	49	cGAS	cgas	JJ
cord-259748-x7dq1sy4	494	50	/	/	SYM
cord-259748-x7dq1sy4	494	51	STING	sting	NN
cord-259748-x7dq1sy4	494	52	-	-	HYPH
cord-259748-x7dq1sy4	494	53	dependent	dependent	JJ
cord-259748-x7dq1sy4	494	54	innate	innate	JJ
cord-259748-x7dq1sy4	494	55	immune	immune	JJ
cord-259748-x7dq1sy4	494	56	response	response	NN
cord-259748-x7dq1sy4	494	57	Restriction	restriction	NN
cord-259748-x7dq1sy4	494	58	by	by	IN
cord-259748-x7dq1sy4	494	59	SAMHD1	SAMHD1	NNS
cord-259748-x7dq1sy4	494	60	limits	limit	NNS
cord-259748-x7dq1sy4	494	61	cGAS	cgas	VBP
cord-259748-x7dq1sy4	494	62	/	/	SYM
cord-259748-x7dq1sy4	494	63	STING	sting	NN
cord-259748-x7dq1sy4	494	64	-	-	HYPH
cord-259748-x7dq1sy4	494	65	dependent	dependent	JJ
cord-259748-x7dq1sy4	494	66	innate	innate	JJ
cord-259748-x7dq1sy4	494	67	and	and	CC
cord-259748-x7dq1sy4	494	68	adaptive	adaptive	JJ
cord-259748-x7dq1sy4	494	69	immune	immune	JJ
cord-259748-x7dq1sy4	494	70	responses	response	NNS
cord-259748-x7dq1sy4	494	71	to	to	IN
cord-259748-x7dq1sy4	494	72	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	494	73	Host	Host	NNP
cord-259748-x7dq1sy4	494	74	restriction	restriction	NN
cord-259748-x7dq1sy4	494	75	factor	factor	NN
cord-259748-x7dq1sy4	495	1	SAMHD1	SAMHD1	NNS
cord-259748-x7dq1sy4	495	2	limits	limit	VBZ
cord-259748-x7dq1sy4	495	3	human	human	JJ
cord-259748-x7dq1sy4	495	4	T	T	NNP
cord-259748-x7dq1sy4	495	5	cell	cell	NN
cord-259748-x7dq1sy4	495	6	leukemia	leukemia	NN
cord-259748-x7dq1sy4	495	7	virus	virus	NN
cord-259748-x7dq1sy4	495	8	type	type	NN
cord-259748-x7dq1sy4	495	9	1	1	CD
cord-259748-x7dq1sy4	495	10	infection	infection	NN
cord-259748-x7dq1sy4	495	11	of	of	IN
cord-259748-x7dq1sy4	495	12	monocytes	monocyte	NNS
cord-259748-x7dq1sy4	495	13	via	via	IN
cord-259748-x7dq1sy4	495	14	STING	sting	NN
cord-259748-x7dq1sy4	495	15	-	-	HYPH
cord-259748-x7dq1sy4	495	16	mediated	mediate	VBN
cord-259748-x7dq1sy4	495	17	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	495	18	SAMHD1	SAMHD1	NNS
cord-259748-x7dq1sy4	495	19	acts	act	NNS
cord-259748-x7dq1sy4	495	20	at	at	IN
cord-259748-x7dq1sy4	495	21	stalled	stall	VBN
cord-259748-x7dq1sy4	495	22	replication	replication	NN
cord-259748-x7dq1sy4	495	23	forks	fork	NNS
cord-259748-x7dq1sy4	495	24	to	to	TO
cord-259748-x7dq1sy4	495	25	prevent	prevent	VB
cord-259748-x7dq1sy4	495	26	interferon	interferon	NN
cord-259748-x7dq1sy4	495	27	induction	induction	NN
cord-259748-x7dq1sy4	496	1	Cyclic	cyclic	JJ
cord-259748-x7dq1sy4	496	2	GMP	GMP	NNP
cord-259748-x7dq1sy4	496	3	-	-	HYPH
cord-259748-x7dq1sy4	496	4	AMP	AMP	NNP
cord-259748-x7dq1sy4	496	5	containing	contain	VBG
cord-259748-x7dq1sy4	496	6	mixed	mixed	JJ
cord-259748-x7dq1sy4	496	7	phosphodiester	phosphodiester	NN
cord-259748-x7dq1sy4	496	8	linkages	linkage	NNS
cord-259748-x7dq1sy4	496	9	is	be	VBZ
cord-259748-x7dq1sy4	496	10	an	an	DT
cord-259748-x7dq1sy4	496	11	endogenous	endogenous	JJ
cord-259748-x7dq1sy4	496	12	high	high	JJ
cord-259748-x7dq1sy4	496	13	-	-	HYPH
cord-259748-x7dq1sy4	496	14	affinity	affinity	NN
cord-259748-x7dq1sy4	496	15	ligand	ligand	NN
cord-259748-x7dq1sy4	496	16	for	for	IN
cord-259748-x7dq1sy4	496	17	STING	sting	NN
cord-259748-x7dq1sy4	497	1	Cyclic	cyclic	JJ
cord-259748-x7dq1sy4	497	2	GMP	GMP	NNP
cord-259748-x7dq1sy4	497	3	-	-	HYPH
cord-259748-x7dq1sy4	497	4	AMP	AMP	NNP
cord-259748-x7dq1sy4	497	5	synthase	synthase	NN
cord-259748-x7dq1sy4	497	6	is	be	VBZ
cord-259748-x7dq1sy4	497	7	an	an	DT
cord-259748-x7dq1sy4	497	8	innate	innate	JJ
cord-259748-x7dq1sy4	497	9	immune	immune	JJ
cord-259748-x7dq1sy4	497	10	sensor	sensor	NN
cord-259748-x7dq1sy4	497	11	of	of	IN
cord-259748-x7dq1sy4	497	12	HIV	HIV	NNP
cord-259748-x7dq1sy4	497	13	and	and	CC
cord-259748-x7dq1sy4	497	14	other	other	JJ
cord-259748-x7dq1sy4	497	15	retroviruses	retrovirus	NNS
cord-259748-x7dq1sy4	498	1	Cell	cell	NN
cord-259748-x7dq1sy4	498	2	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	498	3	immunity	immunity	NN
cord-259748-x7dq1sy4	498	4	spreads	spread	VBZ
cord-259748-x7dq1sy4	498	5	to	to	IN
cord-259748-x7dq1sy4	498	6	bystander	bystander	NN
cord-259748-x7dq1sy4	498	7	cells	cell	NNS
cord-259748-x7dq1sy4	498	8	via	via	IN
cord-259748-x7dq1sy4	498	9	the	the	DT
cord-259748-x7dq1sy4	498	10	intercellular	intercellular	JJ
cord-259748-x7dq1sy4	498	11	transfer	transfer	NN
cord-259748-x7dq1sy4	498	12	of	of	IN
cord-259748-x7dq1sy4	498	13	cGAMP	cgamp	JJ
cord-259748-x7dq1sy4	498	14	Connexin	Connexin	NNP
cord-259748-x7dq1sy4	498	15	-	-	HYPH
cord-259748-x7dq1sy4	498	16	dependent	dependent	JJ
cord-259748-x7dq1sy4	498	17	transfer	transfer	NN
cord-259748-x7dq1sy4	498	18	of	of	IN
cord-259748-x7dq1sy4	498	19	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	499	1	to	to	IN
cord-259748-x7dq1sy4	499	2	phagocytes	phagocyte	NNS
cord-259748-x7dq1sy4	499	3	modulates	modulate	VBZ
cord-259748-x7dq1sy4	499	4	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	499	5	responses	response	NNS
cord-259748-x7dq1sy4	500	1	Cancer	cancer	NN
cord-259748-x7dq1sy4	500	2	-	-	HYPH
cord-259748-x7dq1sy4	500	3	cell	cell	NN
cord-259748-x7dq1sy4	500	4	-	-	HYPH
cord-259748-x7dq1sy4	500	5	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	500	6	cGAS	cgas	JJ
cord-259748-x7dq1sy4	500	7	expression	expression	NN
cord-259748-x7dq1sy4	500	8	mediates	mediate	VBZ
cord-259748-x7dq1sy4	500	9	tumor	tumor	NN
cord-259748-x7dq1sy4	500	10	immunogenicity	immunogenicity	NN
cord-259748-x7dq1sy4	501	1	Viruses	virus	NNS
cord-259748-x7dq1sy4	501	2	transfer	transfer	VBP
cord-259748-x7dq1sy4	501	3	the	the	DT
cord-259748-x7dq1sy4	501	4	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	501	5	second	second	JJ
cord-259748-x7dq1sy4	501	6	messenger	messenger	NN
cord-259748-x7dq1sy4	501	7	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	501	8	between	between	IN
cord-259748-x7dq1sy4	501	9	cells	cell	NNS
cord-259748-x7dq1sy4	501	10	Transmission	transmission	NN
cord-259748-x7dq1sy4	501	11	of	of	IN
cord-259748-x7dq1sy4	501	12	innate	innate	JJ
cord-259748-x7dq1sy4	501	13	immune	immune	JJ
cord-259748-x7dq1sy4	501	14	signaling	signaling	NN
cord-259748-x7dq1sy4	501	15	by	by	IN
cord-259748-x7dq1sy4	501	16	packaging	packaging	NN
cord-259748-x7dq1sy4	501	17	of	of	IN
cord-259748-x7dq1sy4	501	18	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	501	19	in	in	IN
cord-259748-x7dq1sy4	501	20	viral	viral	JJ
cord-259748-x7dq1sy4	501	21	particles	particle	NNS
cord-259748-x7dq1sy4	501	22	cGAS	cgas	VB
cord-259748-x7dq1sy4	501	23	-	-	HYPH
cord-259748-x7dq1sy4	501	24	mediated	mediate	VBN
cord-259748-x7dq1sy4	501	25	innate	innate	JJ
cord-259748-x7dq1sy4	501	26	immunity	immunity	NN
cord-259748-x7dq1sy4	501	27	spreads	spread	VBZ
cord-259748-x7dq1sy4	501	28	intercellularly	intercellularly	RB
cord-259748-x7dq1sy4	501	29	through	through	IN
cord-259748-x7dq1sy4	501	30	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	501	31	envinduced	envinduce	VBD
cord-259748-x7dq1sy4	501	32	membrane	membrane	NN
cord-259748-x7dq1sy4	501	33	fusion	fusion	NN
cord-259748-x7dq1sy4	501	34	sites	site	NNS
cord-259748-x7dq1sy4	501	35	Priming	priming	NN
cord-259748-x7dq1sy4	501	36	of	of	IN
cord-259748-x7dq1sy4	501	37	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	501	38	cells	cell	NNS
cord-259748-x7dq1sy4	501	39	by	by	IN
cord-259748-x7dq1sy4	501	40	DNA	dna	NN
cord-259748-x7dq1sy4	501	41	-	-	HYPH
cord-259748-x7dq1sy4	501	42	containing	contain	VBG
cord-259748-x7dq1sy4	501	43	extracellular	extracellular	JJ
cord-259748-x7dq1sy4	501	44	vesicles	vesicle	NNS
cord-259748-x7dq1sy4	501	45	from	from	IN
cord-259748-x7dq1sy4	501	46	activated	activate	VBN
cord-259748-x7dq1sy4	501	47	T	T	NNP
cord-259748-x7dq1sy4	501	48	cells	cell	NNS
cord-259748-x7dq1sy4	501	49	through	through	IN
cord-259748-x7dq1sy4	501	50	antigen	antigen	NN
cord-259748-x7dq1sy4	501	51	-	-	HYPH
cord-259748-x7dq1sy4	501	52	driven	drive	VBN
cord-259748-x7dq1sy4	501	53	contacts	contact	NNS
cord-259748-x7dq1sy4	501	54	Cells	cell	NNS
cord-259748-x7dq1sy4	501	55	infected	infect	VBN
cord-259748-x7dq1sy4	501	56	with	with	IN
cord-259748-x7dq1sy4	501	57	herpes	herpes	NN
cord-259748-x7dq1sy4	501	58	simplex	simplex	NNP
cord-259748-x7dq1sy4	501	59	virus	virus	NN
cord-259748-x7dq1sy4	501	60	1	1	CD
cord-259748-x7dq1sy4	501	61	export	export	NN
cord-259748-x7dq1sy4	501	62	to	to	IN
cord-259748-x7dq1sy4	501	63	uninfected	uninfected	JJ
cord-259748-x7dq1sy4	501	64	cells	cell	NNS
cord-259748-x7dq1sy4	501	65	exosomes	exosome	NNS
cord-259748-x7dq1sy4	501	66	containing	contain	VBG
cord-259748-x7dq1sy4	501	67	STING	sting	NN
cord-259748-x7dq1sy4	501	68	,	,	,
cord-259748-x7dq1sy4	501	69	viral	viral	JJ
cord-259748-x7dq1sy4	501	70	mRNAs	mRNAs	NNPS
cord-259748-x7dq1sy4	501	71	,	,	,
cord-259748-x7dq1sy4	501	72	and	and	CC
cord-259748-x7dq1sy4	501	73	microRNAs	micrornas	JJ
cord-259748-x7dq1sy4	501	74	SLC19A1	slc19a1	NN
cord-259748-x7dq1sy4	501	75	is	be	VBZ
cord-259748-x7dq1sy4	501	76	an	an	DT
cord-259748-x7dq1sy4	501	77	importer	importer	NN
cord-259748-x7dq1sy4	501	78	of	of	IN
cord-259748-x7dq1sy4	502	1	the	the	DT
cord-259748-x7dq1sy4	502	2	immunotransmitter	immunotransmitter	NNP
cord-259748-x7dq1sy4	502	3	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	502	4	SLC19A1	SLC19A1	NNP
cord-259748-x7dq1sy4	502	5	transports	transport	VBZ
cord-259748-x7dq1sy4	502	6	immunoreactive	immunoreactive	JJ
cord-259748-x7dq1sy4	502	7	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	502	8	dinucleotides	dinucleotide	NNS
cord-259748-x7dq1sy4	502	9	Hydrolysis	Hydrolysis	NNP
cord-259748-x7dq1sy4	502	10	of	of	IN
cord-259748-x7dq1sy4	502	11	2	2	CD
cord-259748-x7dq1sy4	502	12	3	3	CD
cord-259748-x7dq1sy4	502	13	-cGAMP	-cGAMP	NNPS
cord-259748-x7dq1sy4	502	14	by	by	IN
cord-259748-x7dq1sy4	502	15	ENPP1	ENPP1	NNS
cord-259748-x7dq1sy4	502	16	and	and	CC
cord-259748-x7dq1sy4	502	17	design	design	NN
cord-259748-x7dq1sy4	502	18	of	of	IN
cord-259748-x7dq1sy4	502	19	nonhydrolyzable	nonhydrolyzable	JJ
cord-259748-x7dq1sy4	502	20	analogs	analogs	NNP
cord-259748-x7dq1sy4	502	21	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	502	22	facilitates	facilitate	VBZ
cord-259748-x7dq1sy4	502	23	sensing	sensing	NN
cord-259748-x7dq1sy4	502	24	of	of	IN
cord-259748-x7dq1sy4	502	25	extracellular	extracellular	JJ
cord-259748-x7dq1sy4	502	26	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	502	27	dinucleotides	dinucleotide	NNS
cord-259748-x7dq1sy4	502	28	to	to	TO
cord-259748-x7dq1sy4	502	29	activate	activate	VB
cord-259748-x7dq1sy4	502	30	innate	innate	JJ
cord-259748-x7dq1sy4	502	31	immunity	immunity	NN
cord-259748-x7dq1sy4	502	32	STING	sting	NN
cord-259748-x7dq1sy4	502	33	regulates	regulate	VBZ
cord-259748-x7dq1sy4	502	34	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	502	35	DNA	dna	NN
cord-259748-x7dq1sy4	502	36	-	-	HYPH
cord-259748-x7dq1sy4	502	37	mediated	mediate	VBN
cord-259748-x7dq1sy4	502	38	,	,	,
cord-259748-x7dq1sy4	503	1	type	type	NN
cord-259748-x7dq1sy4	503	2	I	-PRON-	PRP
cord-259748-x7dq1sy4	503	3	interferon	interferon	NN
cord-259748-x7dq1sy4	503	4	-	-	HYPH
cord-259748-x7dq1sy4	503	5	dependent	dependent	JJ
cord-259748-x7dq1sy4	503	6	innate	innate	JJ
cord-259748-x7dq1sy4	503	7	immunity	immunity	NN
cord-259748-x7dq1sy4	503	8	Activation	activation	NN
cord-259748-x7dq1sy4	503	9	by	by	IN
cord-259748-x7dq1sy4	503	10	translocation	translocation	NN
cord-259748-x7dq1sy4	503	11	from	from	IN
cord-259748-x7dq1sy4	503	12	the	the	DT
cord-259748-x7dq1sy4	503	13	ER	ER	NNP
cord-259748-x7dq1sy4	503	14	is	be	VBZ
cord-259748-x7dq1sy4	503	15	associated	associate	VBN
cord-259748-x7dq1sy4	503	16	with	with	IN
cord-259748-x7dq1sy4	503	17	infection	infection	NN
cord-259748-x7dq1sy4	503	18	and	and	CC
cord-259748-x7dq1sy4	503	19	Autoinflammatory	Autoinflammatory	NNP
cord-259748-x7dq1sy4	503	20	disease	disease	NN
cord-259748-x7dq1sy4	504	1	Atg9a	Atg9a	NNP
cord-259748-x7dq1sy4	504	2	controls	control	VBZ
cord-259748-x7dq1sy4	504	3	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	504	4	-	-	HYPH
cord-259748-x7dq1sy4	504	5	driven	drive	VBN
cord-259748-x7dq1sy4	504	6	dynamic	dynamic	JJ
cord-259748-x7dq1sy4	504	7	translocation	translocation	NN
cord-259748-x7dq1sy4	504	8	of	of	IN
cord-259748-x7dq1sy4	504	9	STING	sting	NN
cord-259748-x7dq1sy4	504	10	and	and	CC
cord-259748-x7dq1sy4	504	11	the	the	DT
cord-259748-x7dq1sy4	504	12	innate	innate	JJ
cord-259748-x7dq1sy4	504	13	immune	immune	JJ
cord-259748-x7dq1sy4	504	14	response	response	NN
cord-259748-x7dq1sy4	505	1	iRhom2	iRhom2	NNP
cord-259748-x7dq1sy4	505	2	is	be	VBZ
cord-259748-x7dq1sy4	505	3	essential	essential	JJ
cord-259748-x7dq1sy4	505	4	for	for	IN
cord-259748-x7dq1sy4	505	5	innate	innate	JJ
cord-259748-x7dq1sy4	505	6	immunity	immunity	NN
cord-259748-x7dq1sy4	505	7	to	to	IN
cord-259748-x7dq1sy4	505	8	DNA	dna	NN
cord-259748-x7dq1sy4	505	9	viruses	virus	NNS
cord-259748-x7dq1sy4	505	10	by	by	IN
cord-259748-x7dq1sy4	505	11	mediating	mediate	VBG
cord-259748-x7dq1sy4	505	12	trafficking	trafficking	NN
cord-259748-x7dq1sy4	505	13	and	and	CC
cord-259748-x7dq1sy4	505	14	stability	stability	NN
cord-259748-x7dq1sy4	505	15	of	of	IN
cord-259748-x7dq1sy4	505	16	the	the	DT
cord-259748-x7dq1sy4	505	17	adaptor	adaptor	NN
cord-259748-x7dq1sy4	505	18	STING	sting	NN
cord-259748-x7dq1sy4	506	1	TMED2	TMED2	NNP
cord-259748-x7dq1sy4	506	2	potentiates	potentiate	VBZ
cord-259748-x7dq1sy4	506	3	cellular	cellular	JJ
cord-259748-x7dq1sy4	506	4	IFN	IFN	NNP
cord-259748-x7dq1sy4	506	5	responses	response	NNS
cord-259748-x7dq1sy4	506	6	to	to	IN
cord-259748-x7dq1sy4	506	7	DNA	dna	NN
cord-259748-x7dq1sy4	506	8	viruses	virus	NNS
cord-259748-x7dq1sy4	506	9	by	by	IN
cord-259748-x7dq1sy4	506	10	reinforcing	reinforce	VBG
cord-259748-x7dq1sy4	506	11	MITA	MITA	NNP
cord-259748-x7dq1sy4	506	12	dimerization	dimerization	NN
cord-259748-x7dq1sy4	506	13	and	and	CC
cord-259748-x7dq1sy4	506	14	facilitating	facilitate	VBG
cord-259748-x7dq1sy4	506	15	its	-PRON-	PRP$
cord-259748-x7dq1sy4	506	16	trafficking	traffic	VBG
cord-259748-x7dq1sy4	506	17	Autophagy	Autophagy	NNP
cord-259748-x7dq1sy4	506	18	induction	induction	NN
cord-259748-x7dq1sy4	506	19	via	via	IN
cord-259748-x7dq1sy4	506	20	STING	sting	NN
cord-259748-x7dq1sy4	506	21	trafficking	trafficking	NN
cord-259748-x7dq1sy4	507	1	is	be	VBZ
cord-259748-x7dq1sy4	507	2	a	a	DT
cord-259748-x7dq1sy4	507	3	primordial	primordial	JJ
cord-259748-x7dq1sy4	507	4	function	function	NN
cord-259748-x7dq1sy4	507	5	of	of	IN
cord-259748-x7dq1sy4	507	6	the	the	DT
cord-259748-x7dq1sy4	507	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	507	8	pathway	pathway	NN
cord-259748-x7dq1sy4	507	9	Phosphorylation	Phosphorylation	NNP
cord-259748-x7dq1sy4	507	10	of	of	IN
cord-259748-x7dq1sy4	507	11	innate	innate	JJ
cord-259748-x7dq1sy4	507	12	immune	immune	JJ
cord-259748-x7dq1sy4	507	13	adaptor	adaptor	NN
cord-259748-x7dq1sy4	507	14	proteins	protein	NNS
cord-259748-x7dq1sy4	507	15	MAVS	mavs	RB
cord-259748-x7dq1sy4	507	16	,	,	,
cord-259748-x7dq1sy4	507	17	STING	sting	NN
cord-259748-x7dq1sy4	507	18	,	,	,
cord-259748-x7dq1sy4	507	19	and	and	CC
cord-259748-x7dq1sy4	507	20	TRIF	TRIF	NNP
cord-259748-x7dq1sy4	508	1	induces	induce	VBZ
cord-259748-x7dq1sy4	508	2	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	508	3	activation	activation	NN
cord-259748-x7dq1sy4	508	4	STING	sting	NN
cord-259748-x7dq1sy4	508	5	specifies	specify	VBZ
cord-259748-x7dq1sy4	508	6	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	508	7	phosphorylation	phosphorylation	NN
cord-259748-x7dq1sy4	508	8	by	by	IN
cord-259748-x7dq1sy4	508	9	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	508	10	in	in	IN
cord-259748-x7dq1sy4	508	11	the	the	DT
cord-259748-x7dq1sy4	508	12	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	508	13	DNA	dna	NN
cord-259748-x7dq1sy4	508	14	signaling	signal	VBG
cord-259748-x7dq1sy4	508	15	pathway	pathway	NN
cord-259748-x7dq1sy4	508	16	Modular	modular	JJ
cord-259748-x7dq1sy4	508	17	architecture	architecture	NN
cord-259748-x7dq1sy4	508	18	of	of	IN
cord-259748-x7dq1sy4	508	19	the	the	DT
cord-259748-x7dq1sy4	508	20	STING	STING	NNP
cord-259748-x7dq1sy4	508	21	C	c	NN
cord-259748-x7dq1sy4	508	22	-	-	HYPH
cord-259748-x7dq1sy4	508	23	terminal	terminal	NN
cord-259748-x7dq1sy4	508	24	tail	tail	NN
cord-259748-x7dq1sy4	508	25	allows	allow	VBZ
cord-259748-x7dq1sy4	508	26	interferon	interferon	NN
cord-259748-x7dq1sy4	508	27	and	and	CC
cord-259748-x7dq1sy4	508	28	NF	NF	NNP
cord-259748-x7dq1sy4	508	29	-	-	HYPH
cord-259748-x7dq1sy4	508	30	kappaB	kappaB	NNP
cord-259748-x7dq1sy4	508	31	signaling	signal	VBG
cord-259748-x7dq1sy4	508	32	adaptation	adaptation	NN
cord-259748-x7dq1sy4	509	1	Structural	structural	JJ
cord-259748-x7dq1sy4	509	2	basis	basis	NN
cord-259748-x7dq1sy4	509	3	of	of	IN
cord-259748-x7dq1sy4	509	4	STING	sting	NN
cord-259748-x7dq1sy4	509	5	binding	bind	VBG
cord-259748-x7dq1sy4	509	6	with	with	IN
cord-259748-x7dq1sy4	509	7	and	and	CC
cord-259748-x7dq1sy4	509	8	phosphorylation	phosphorylation	NN
cord-259748-x7dq1sy4	509	9	by	by	IN
cord-259748-x7dq1sy4	510	1	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	510	2	A	a	DT
cord-259748-x7dq1sy4	510	3	conserved	conserved	JJ
cord-259748-x7dq1sy4	510	4	PLPLRT	PLPLRT	NNP
cord-259748-x7dq1sy4	510	5	/	/	SYM
cord-259748-x7dq1sy4	510	6	SD	sd	NN
cord-259748-x7dq1sy4	510	7	motif	motif	NN
cord-259748-x7dq1sy4	510	8	of	of	IN
cord-259748-x7dq1sy4	510	9	STING	sting	NN
cord-259748-x7dq1sy4	510	10	mediates	mediate	VBZ
cord-259748-x7dq1sy4	510	11	the	the	DT
cord-259748-x7dq1sy4	510	12	recruitment	recruitment	NN
cord-259748-x7dq1sy4	510	13	and	and	CC
cord-259748-x7dq1sy4	510	14	activation	activation	NN
cord-259748-x7dq1sy4	510	15	of	of	IN
cord-259748-x7dq1sy4	510	16	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	510	17	Activation	Activation	NNP
cord-259748-x7dq1sy4	510	18	of	of	IN
cord-259748-x7dq1sy4	510	19	STING	sting	NN
cord-259748-x7dq1sy4	510	20	requires	require	VBZ
cord-259748-x7dq1sy4	510	21	palmitoylation	palmitoylation	NN
cord-259748-x7dq1sy4	510	22	at	at	IN
cord-259748-x7dq1sy4	510	23	the	the	DT
cord-259748-x7dq1sy4	510	24	Golgi	Golgi	NNP
cord-259748-x7dq1sy4	510	25	Ubiquitination	Ubiquitination	NNP
cord-259748-x7dq1sy4	510	26	of	of	IN
cord-259748-x7dq1sy4	510	27	STING	sting	NN
cord-259748-x7dq1sy4	510	28	at	at	IN
cord-259748-x7dq1sy4	510	29	lysine	lysine	NN
cord-259748-x7dq1sy4	510	30	224	224	CD
cord-259748-x7dq1sy4	510	31	controls	control	NNS
cord-259748-x7dq1sy4	510	32	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	510	33	activation	activation	NN
cord-259748-x7dq1sy4	510	34	Non	non	JJ
cord-259748-x7dq1sy4	510	35	-	-	JJ
cord-259748-x7dq1sy4	510	36	canonical	canonical	JJ
cord-259748-x7dq1sy4	510	37	NF	nf	NN
cord-259748-x7dq1sy4	510	38	-	-	HYPH
cord-259748-x7dq1sy4	510	39	kappaB	kappaB	NNP
cord-259748-x7dq1sy4	510	40	antagonizes	antagonize	VBZ
cord-259748-x7dq1sy4	510	41	STING	sting	NN
cord-259748-x7dq1sy4	510	42	sensor	sensor	NN
cord-259748-x7dq1sy4	510	43	-	-	HYPH
cord-259748-x7dq1sy4	510	44	mediated	mediate	VBN
cord-259748-x7dq1sy4	510	45	DNA	dna	NN
cord-259748-x7dq1sy4	510	46	sensing	sensing	NN
cord-259748-x7dq1sy4	510	47	in	in	IN
cord-259748-x7dq1sy4	510	48	radiotherapy	radiotherapy	NN
cord-259748-x7dq1sy4	510	49	Immunomodulatory	immunomodulatory	JJ
cord-259748-x7dq1sy4	510	50	functions	function	NNS
cord-259748-x7dq1sy4	510	51	of	of	IN
cord-259748-x7dq1sy4	510	52	type	type	NN
cord-259748-x7dq1sy4	511	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	511	2	interferons	interferon	NNS
cord-259748-x7dq1sy4	511	3	DNA	dna	NN
cord-259748-x7dq1sy4	511	4	-	-	HYPH
cord-259748-x7dq1sy4	511	5	binding	bind	VBG
cord-259748-x7dq1sy4	511	6	landscape	landscape	NN
cord-259748-x7dq1sy4	511	7	of	of	IN
cord-259748-x7dq1sy4	511	8	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	511	9	,	,	,
cord-259748-x7dq1sy4	511	10	IRF5	IRF5	NNP
cord-259748-x7dq1sy4	511	11	and	and	CC
cord-259748-x7dq1sy4	511	12	IRF7	IRF7	NNP
cord-259748-x7dq1sy4	511	13	dimers	dimer	NNS
cord-259748-x7dq1sy4	511	14	:	:	:
cord-259748-x7dq1sy4	511	15	implications	implication	NNS
cord-259748-x7dq1sy4	511	16	for	for	IN
cord-259748-x7dq1sy4	511	17	dimer	dimer	NN
cord-259748-x7dq1sy4	511	18	-	-	HYPH
cord-259748-x7dq1sy4	511	19	specific	specific	JJ
cord-259748-x7dq1sy4	511	20	gene	gene	NN
cord-259748-x7dq1sy4	511	21	regulation	regulation	NN
cord-259748-x7dq1sy4	511	22	Attenuation	attenuation	NN
cord-259748-x7dq1sy4	511	23	of	of	IN
cord-259748-x7dq1sy4	511	24	cGAS	cgas	NN
cord-259748-x7dq1sy4	511	25	-	-	HYPH
cord-259748-x7dq1sy4	511	26	STING	sting	NN
cord-259748-x7dq1sy4	511	27	signaling	signaling	NN
cord-259748-x7dq1sy4	511	28	is	be	VBZ
cord-259748-x7dq1sy4	511	29	mediated	mediate	VBN
cord-259748-x7dq1sy4	511	30	by	by	IN
cord-259748-x7dq1sy4	511	31	a	a	DT
cord-259748-x7dq1sy4	511	32	p62	p62	NN
cord-259748-x7dq1sy4	511	33	/	/	SYM
cord-259748-x7dq1sy4	511	34	SQSTM1-dependent	sqstm1-dependent	NN
cord-259748-x7dq1sy4	511	35	autophagy	autophagy	NN
cord-259748-x7dq1sy4	511	36	pathway	pathway	NN
cord-259748-x7dq1sy4	511	37	activated	activate	VBN
cord-259748-x7dq1sy4	511	38	by	by	IN
cord-259748-x7dq1sy4	511	39	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	511	40	Positive	Positive	NNP
cord-259748-x7dq1sy4	511	41	feedback	feedback	NN
cord-259748-x7dq1sy4	511	42	regulation	regulation	NN
cord-259748-x7dq1sy4	511	43	of	of	IN
cord-259748-x7dq1sy4	511	44	type	type	NN
cord-259748-x7dq1sy4	512	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	512	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	512	3	production	production	NN
cord-259748-x7dq1sy4	512	4	by	by	IN
cord-259748-x7dq1sy4	512	5	the	the	DT
cord-259748-x7dq1sy4	512	6	IFN	IFN	NNP
cord-259748-x7dq1sy4	512	7	-	-	HYPH
cord-259748-x7dq1sy4	512	8	inducible	inducible	JJ
cord-259748-x7dq1sy4	512	9	DNA	dna	NN
cord-259748-x7dq1sy4	512	10	sensor	sensor	NN
cord-259748-x7dq1sy4	512	11	cGAS	cgas	NN
cord-259748-x7dq1sy4	513	1	Positive	positive	JJ
cord-259748-x7dq1sy4	513	2	feedback	feedback	NN
cord-259748-x7dq1sy4	513	3	regulation	regulation	NN
cord-259748-x7dq1sy4	513	4	of	of	IN
cord-259748-x7dq1sy4	513	5	type	type	NN
cord-259748-x7dq1sy4	514	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	514	2	interferon	interferon	RB
cord-259748-x7dq1sy4	514	3	by	by	IN
cord-259748-x7dq1sy4	514	4	the	the	DT
cord-259748-x7dq1sy4	514	5	interferon	interferon	NN
cord-259748-x7dq1sy4	514	6	-	-	HYPH
cord-259748-x7dq1sy4	514	7	stimulated	stimulate	VBN
cord-259748-x7dq1sy4	514	8	gene	gene	NN
cord-259748-x7dq1sy4	514	9	STING	sting	NN
cord-259748-x7dq1sy4	514	10	STING	sting	NN
cord-259748-x7dq1sy4	514	11	-	-	HYPH
cord-259748-x7dq1sy4	514	12	mediated	mediate	VBN
cord-259748-x7dq1sy4	514	13	disruption	disruption	NN
cord-259748-x7dq1sy4	514	14	of	of	IN
cord-259748-x7dq1sy4	514	15	calcium	calcium	NN
cord-259748-x7dq1sy4	514	16	homeostasis	homeostasis	NN
cord-259748-x7dq1sy4	514	17	chronically	chronically	RB
cord-259748-x7dq1sy4	514	18	activates	activate	VBZ
cord-259748-x7dq1sy4	514	19	ER	ER	NNP
cord-259748-x7dq1sy4	514	20	stress	stress	NN
cord-259748-x7dq1sy4	514	21	and	and	CC
cord-259748-x7dq1sy4	514	22	primes	prime	VBZ
cord-259748-x7dq1sy4	514	23	T	T	NNP
cord-259748-x7dq1sy4	514	24	cell	cell	NN
cord-259748-x7dq1sy4	514	25	death	death	NN
cord-259748-x7dq1sy4	514	26	STING	sting	NN
cord-259748-x7dq1sy4	514	27	senses	sense	VBZ
cord-259748-x7dq1sy4	514	28	microbial	microbial	JJ
cord-259748-x7dq1sy4	514	29	viability	viability	NN
cord-259748-x7dq1sy4	514	30	to	to	TO
cord-259748-x7dq1sy4	514	31	orchestrate	orchestrate	VB
cord-259748-x7dq1sy4	514	32	stress	stress	NN
cord-259748-x7dq1sy4	514	33	-	-	HYPH
cord-259748-x7dq1sy4	514	34	mediated	mediate	VBN
cord-259748-x7dq1sy4	514	35	autophagy	autophagy	NN
cord-259748-x7dq1sy4	514	36	of	of	IN
cord-259748-x7dq1sy4	514	37	the	the	DT
cord-259748-x7dq1sy4	514	38	endoplasmic	endoplasmic	NN
cord-259748-x7dq1sy4	514	39	reticulum	reticulum	NN
cord-259748-x7dq1sy4	514	40	Chronic	Chronic	NNP
cord-259748-x7dq1sy4	514	41	innate	innate	JJ
cord-259748-x7dq1sy4	514	42	immune	immune	JJ
cord-259748-x7dq1sy4	514	43	activation	activation	NN
cord-259748-x7dq1sy4	514	44	of	of	IN
cord-259748-x7dq1sy4	514	45	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	514	46	suppresses	suppress	VBZ
cord-259748-x7dq1sy4	514	47	mTORC1	mtorc1	CD
cord-259748-x7dq1sy4	514	48	activity	activity	NN
cord-259748-x7dq1sy4	514	49	and	and	CC
cord-259748-x7dq1sy4	514	50	dysregulates	dysregulate	NNS
cord-259748-x7dq1sy4	515	1	cellular	cellular	JJ
cord-259748-x7dq1sy4	515	2	metabolism	metabolism	NN
cord-259748-x7dq1sy4	515	3	mTOR	mTOR	NNP
cord-259748-x7dq1sy4	515	4	signaling	signal	VBG
cord-259748-x7dq1sy4	515	5	in	in	IN
cord-259748-x7dq1sy4	515	6	growth	growth	NN
cord-259748-x7dq1sy4	515	7	,	,	,
cord-259748-x7dq1sy4	515	8	metabolism	metabolism	NN
cord-259748-x7dq1sy4	515	9	,	,	,
cord-259748-x7dq1sy4	515	10	and	and	CC
cord-259748-x7dq1sy4	515	11	disease	disease	NN
cord-259748-x7dq1sy4	515	12	Crosstalk	crosstalk	NN
cord-259748-x7dq1sy4	515	13	between	between	IN
cord-259748-x7dq1sy4	515	14	the	the	DT
cord-259748-x7dq1sy4	515	15	cGAS	cgas	JJ
cord-259748-x7dq1sy4	515	16	DNA	dna	NN
cord-259748-x7dq1sy4	515	17	sensor	sensor	NN
cord-259748-x7dq1sy4	515	18	and	and	CC
cord-259748-x7dq1sy4	515	19	Beclin-1	Beclin-1	NNP
cord-259748-x7dq1sy4	515	20	autophagy	autophagy	NN
cord-259748-x7dq1sy4	515	21	protein	protein	NN
cord-259748-x7dq1sy4	515	22	shapes	shape	NNS
cord-259748-x7dq1sy4	515	23	innate	innate	VBP
cord-259748-x7dq1sy4	515	24	antimicrobial	antimicrobial	JJ
cord-259748-x7dq1sy4	515	25	immune	immune	JJ
cord-259748-x7dq1sy4	515	26	responses	response	NNS
cord-259748-x7dq1sy4	516	1	A	a	DT
cord-259748-x7dq1sy4	516	2	brief	brief	JJ
cord-259748-x7dq1sy4	516	3	history	history	NN
cord-259748-x7dq1sy4	516	4	of	of	IN
cord-259748-x7dq1sy4	516	5	autophagy	autophagy	NN
cord-259748-x7dq1sy4	516	6	from	from	IN
cord-259748-x7dq1sy4	516	7	cell	cell	NN
cord-259748-x7dq1sy4	516	8	biology	biology	NN
cord-259748-x7dq1sy4	516	9	to	to	IN
cord-259748-x7dq1sy4	516	10	physiology	physiology	NN
cord-259748-x7dq1sy4	516	11	and	and	CC
cord-259748-x7dq1sy4	516	12	disease	disease	NN
cord-259748-x7dq1sy4	516	13	Autophagy	Autophagy	NNP
cord-259748-x7dq1sy4	516	14	in	in	IN
cord-259748-x7dq1sy4	516	15	the	the	DT
cord-259748-x7dq1sy4	516	16	renewal	renewal	NN
cord-259748-x7dq1sy4	516	17	,	,	,
cord-259748-x7dq1sy4	516	18	differentiation	differentiation	NN
cord-259748-x7dq1sy4	516	19	and	and	CC
cord-259748-x7dq1sy4	516	20	homeostasis	homeostasis	NN
cord-259748-x7dq1sy4	516	21	of	of	IN
cord-259748-x7dq1sy4	516	22	immune	immune	JJ
cord-259748-x7dq1sy4	516	23	cells	cell	NNS
cord-259748-x7dq1sy4	516	24	STING	sting	VBP
cord-259748-x7dq1sy4	516	25	directly	directly	RB
cord-259748-x7dq1sy4	516	26	activates	activate	VBZ
cord-259748-x7dq1sy4	516	27	autophagy	autophagy	NN
cord-259748-x7dq1sy4	516	28	to	to	TO
cord-259748-x7dq1sy4	516	29	tune	tune	VB
cord-259748-x7dq1sy4	516	30	the	the	DT
cord-259748-x7dq1sy4	516	31	innate	innate	JJ
cord-259748-x7dq1sy4	516	32	immune	immune	JJ
cord-259748-x7dq1sy4	516	33	response	response	NN
cord-259748-x7dq1sy4	516	34	Mycobacterium	Mycobacterium	NNP
cord-259748-x7dq1sy4	516	35	tuberculosis	tuberculosis	NN
cord-259748-x7dq1sy4	516	36	is	be	VBZ
cord-259748-x7dq1sy4	516	37	protected	protect	VBN
cord-259748-x7dq1sy4	516	38	from	from	IN
cord-259748-x7dq1sy4	516	39	NADPH	NADPH	NNP
cord-259748-x7dq1sy4	516	40	oxidase	oxidase	NN
cord-259748-x7dq1sy4	516	41	and	and	CC
cord-259748-x7dq1sy4	516	42	LC3-associated	lc3-associate	VBN
cord-259748-x7dq1sy4	516	43	phagocytosis	phagocytosis	NN
cord-259748-x7dq1sy4	516	44	by	by	IN
cord-259748-x7dq1sy4	516	45	the	the	DT
cord-259748-x7dq1sy4	516	46	LCP	LCP	NNP
cord-259748-x7dq1sy4	516	47	protein	protein	NN
cord-259748-x7dq1sy4	516	48	CpsA	CpsA	.
cord-259748-x7dq1sy4	516	49	Extracellular	Extracellular	NNP
cord-259748-x7dq1sy4	516	50	M.	M.	NNP
cord-259748-x7dq1sy4	516	51	tuberculosis	tuberculosis	NN
cord-259748-x7dq1sy4	516	52	DNA	dna	NN
cord-259748-x7dq1sy4	516	53	targets	target	NNS
cord-259748-x7dq1sy4	516	54	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	516	55	for	for	IN
cord-259748-x7dq1sy4	516	56	autophagy	autophagy	NN
cord-259748-x7dq1sy4	516	57	by	by	IN
cord-259748-x7dq1sy4	516	58	activating	activate	VBG
cord-259748-x7dq1sy4	516	59	the	the	DT
cord-259748-x7dq1sy4	516	60	host	host	NN
cord-259748-x7dq1sy4	516	61	DNA	dna	NN
cord-259748-x7dq1sy4	516	62	-	-	HYPH
cord-259748-x7dq1sy4	516	63	sensing	sense	VBG
cord-259748-x7dq1sy4	516	64	pathway	pathway	NN
cord-259748-x7dq1sy4	516	65	UPR	UPR	NNP
cord-259748-x7dq1sy4	516	66	,	,	,
cord-259748-x7dq1sy4	516	67	autophagy	autophagy	NN
cord-259748-x7dq1sy4	516	68	,	,	,
cord-259748-x7dq1sy4	516	69	and	and	CC
cord-259748-x7dq1sy4	516	70	mitochondria	mitochondria	NN
cord-259748-x7dq1sy4	516	71	crosstalk	crosstalk	NN
cord-259748-x7dq1sy4	517	1	underlies	underlie	VBZ
cord-259748-x7dq1sy4	517	2	the	the	DT
cord-259748-x7dq1sy4	517	3	ER	ER	NNP
cord-259748-x7dq1sy4	517	4	stress	stress	NN
cord-259748-x7dq1sy4	517	5	response	response	NN
cord-259748-x7dq1sy4	518	1	Dnase2a	Dnase2a	NNP
cord-259748-x7dq1sy4	518	2	deficiency	deficiency	NN
cord-259748-x7dq1sy4	518	3	uncovers	uncover	VBZ
cord-259748-x7dq1sy4	518	4	lysosomal	lysosomal	JJ
cord-259748-x7dq1sy4	518	5	clearance	clearance	NN
cord-259748-x7dq1sy4	518	6	of	of	IN
cord-259748-x7dq1sy4	518	7	damaged	damaged	JJ
cord-259748-x7dq1sy4	518	8	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	518	9	DNA	dna	NN
cord-259748-x7dq1sy4	518	10	via	via	IN
cord-259748-x7dq1sy4	518	11	autophagy	autophagy	NN
cord-259748-x7dq1sy4	518	12	Self	self	NN
cord-259748-x7dq1sy4	518	13	-	-	HYPH
cord-259748-x7dq1sy4	518	14	consumption	consumption	NN
cord-259748-x7dq1sy4	518	15	:	:	:
cord-259748-x7dq1sy4	518	16	the	the	DT
cord-259748-x7dq1sy4	518	17	interplay	interplay	NN
cord-259748-x7dq1sy4	518	18	of	of	IN
cord-259748-x7dq1sy4	518	19	autophagy	autophagy	NN
cord-259748-x7dq1sy4	518	20	and	and	CC
cord-259748-x7dq1sy4	518	21	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	518	22	Trafficking	trafficking	NN
cord-259748-x7dq1sy4	518	23	-	-	HYPH
cord-259748-x7dq1sy4	518	24	mediated	mediate	VBN
cord-259748-x7dq1sy4	518	25	STING	sting	NN
cord-259748-x7dq1sy4	518	26	degradation	degradation	NN
cord-259748-x7dq1sy4	518	27	requires	require	VBZ
cord-259748-x7dq1sy4	518	28	sorting	sort	VBG
cord-259748-x7dq1sy4	518	29	to	to	IN
cord-259748-x7dq1sy4	518	30	acidified	acidified	JJ
cord-259748-x7dq1sy4	518	31	endolysosomes	endolysosome	NNS
cord-259748-x7dq1sy4	518	32	and	and	CC
cord-259748-x7dq1sy4	518	33	can	can	MD
cord-259748-x7dq1sy4	518	34	be	be	VB
cord-259748-x7dq1sy4	518	35	targeted	target	VBN
cord-259748-x7dq1sy4	518	36	to	to	TO
cord-259748-x7dq1sy4	518	37	enhance	enhance	VB
cord-259748-x7dq1sy4	518	38	anti	anti	JJ
cord-259748-x7dq1sy4	518	39	-	-	JJ
cord-259748-x7dq1sy4	518	40	tumor	tumor	JJ
cord-259748-x7dq1sy4	518	41	response	response	NN
cord-259748-x7dq1sy4	519	1	The	the	DT
cord-259748-x7dq1sy4	519	2	DNA	dna	NN
cord-259748-x7dq1sy4	519	3	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	519	4	in	in	IN
cord-259748-x7dq1sy4	519	5	human	human	JJ
cord-259748-x7dq1sy4	519	6	myeloid	myeloid	NN
cord-259748-x7dq1sy4	519	7	cells	cell	NNS
cord-259748-x7dq1sy4	519	8	is	be	VBZ
cord-259748-x7dq1sy4	519	9	initiated	initiate	VBN
cord-259748-x7dq1sy4	519	10	by	by	IN
cord-259748-x7dq1sy4	519	11	a	a	DT
cord-259748-x7dq1sy4	519	12	STING	sting	NN
cord-259748-x7dq1sy4	519	13	-	-	HYPH
cord-259748-x7dq1sy4	519	14	Cell	cell	NN
cord-259748-x7dq1sy4	519	15	death	death	NN
cord-259748-x7dq1sy4	519	16	program	program	NN
cord-259748-x7dq1sy4	519	17	upstream	upstream	RB
cord-259748-x7dq1sy4	519	18	of	of	IN
cord-259748-x7dq1sy4	519	19	NLRP3	nlrp3	NN
cord-259748-x7dq1sy4	519	20	AIM2	AIM2	NNP
cord-259748-x7dq1sy4	519	21	recognizes	recognize	VBZ
cord-259748-x7dq1sy4	519	22	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	519	23	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	519	24	and	and	CC
cord-259748-x7dq1sy4	519	25	forms	form	VBZ
cord-259748-x7dq1sy4	519	26	a	a	DT
cord-259748-x7dq1sy4	519	27	caspase-1-activating	caspase-1-activate	VBG
cord-259748-x7dq1sy4	519	28	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	519	29	with	with	IN
cord-259748-x7dq1sy4	519	30	ASC	ASC	NNP
cord-259748-x7dq1sy4	519	31	Antagonism	Antagonism	NNP
cord-259748-x7dq1sy4	519	32	of	of	IN
cord-259748-x7dq1sy4	519	33	the	the	DT
cord-259748-x7dq1sy4	519	34	STING	sting	NN
cord-259748-x7dq1sy4	519	35	pathway	pathway	NN
cord-259748-x7dq1sy4	519	36	via	via	IN
cord-259748-x7dq1sy4	519	37	activation	activation	NN
cord-259748-x7dq1sy4	519	38	of	of	IN
cord-259748-x7dq1sy4	519	39	the	the	DT
cord-259748-x7dq1sy4	519	40	AIM2	AIM2	NNP
cord-259748-x7dq1sy4	519	41	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	519	42	by	by	IN
cord-259748-x7dq1sy4	520	1	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	520	2	DNA	DNA	NNP
cord-259748-x7dq1sy4	520	3	Inflammasome	Inflammasome	NNP
cord-259748-x7dq1sy4	520	4	activation	activation	NN
cord-259748-x7dq1sy4	520	5	triggers	trigger	NNS
cord-259748-x7dq1sy4	520	6	caspase-1-mediated	caspase-1-mediated	JJ
cord-259748-x7dq1sy4	520	7	cleavage	cleavage	NN
cord-259748-x7dq1sy4	520	8	of	of	IN
cord-259748-x7dq1sy4	520	9	cGAS	cgas	NN
cord-259748-x7dq1sy4	520	10	to	to	TO
cord-259748-x7dq1sy4	520	11	regulate	regulate	VB
cord-259748-x7dq1sy4	520	12	responses	response	NNS
cord-259748-x7dq1sy4	520	13	to	to	IN
cord-259748-x7dq1sy4	520	14	DNA	dna	NN
cord-259748-x7dq1sy4	520	15	virus	virus	NN
cord-259748-x7dq1sy4	520	16	infection	infection	NN
cord-259748-x7dq1sy4	521	1	Gasdermin	Gasdermin	NNP
cord-259748-x7dq1sy4	521	2	D	d	NN
cord-259748-x7dq1sy4	521	3	restrains	restrain	VBZ
cord-259748-x7dq1sy4	521	4	Type	type	NN
cord-259748-x7dq1sy4	521	5	I	-PRON-	PRP
cord-259748-x7dq1sy4	521	6	interferon	interferon	VBD
cord-259748-x7dq1sy4	521	7	response	response	NN
cord-259748-x7dq1sy4	521	8	to	to	IN
cord-259748-x7dq1sy4	521	9	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	521	10	DNA	dna	NN
cord-259748-x7dq1sy4	521	11	by	by	IN
cord-259748-x7dq1sy4	521	12	disrupting	disrupt	VBG
cord-259748-x7dq1sy4	521	13	ionic	ionic	JJ
cord-259748-x7dq1sy4	521	14	homeostasis	homeostasis	NN
cord-259748-x7dq1sy4	521	15	A	a	DT
cord-259748-x7dq1sy4	521	16	noncanonical	noncanonical	JJ
cord-259748-x7dq1sy4	521	17	function	function	NN
cord-259748-x7dq1sy4	521	18	of	of	IN
cord-259748-x7dq1sy4	521	19	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	521	20	in	in	IN
cord-259748-x7dq1sy4	521	21	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	521	22	priming	priming	NN
cord-259748-x7dq1sy4	521	23	and	and	CC
cord-259748-x7dq1sy4	521	24	activation	activation	NN
cord-259748-x7dq1sy4	521	25	Viral	Viral	NNP
cord-259748-x7dq1sy4	521	26	DNA	dna	NN
cord-259748-x7dq1sy4	521	27	binding	binding	NN
cord-259748-x7dq1sy4	521	28	to	to	IN
cord-259748-x7dq1sy4	521	29	NLRC3	NLRC3	NNP
cord-259748-x7dq1sy4	521	30	,	,	,
cord-259748-x7dq1sy4	521	31	an	an	DT
cord-259748-x7dq1sy4	521	32	inhibitory	inhibitory	JJ
cord-259748-x7dq1sy4	521	33	nucleic	nucleic	JJ
cord-259748-x7dq1sy4	521	34	acid	acid	NN
cord-259748-x7dq1sy4	521	35	sensor	sensor	NN
cord-259748-x7dq1sy4	521	36	,	,	,
cord-259748-x7dq1sy4	521	37	unleashes	unleash	VBZ
cord-259748-x7dq1sy4	521	38	STING	sting	NN
cord-259748-x7dq1sy4	521	39	,	,	,
cord-259748-x7dq1sy4	521	40	a	a	DT
cord-259748-x7dq1sy4	521	41	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	521	42	dinucleotide	dinucleotide	NN
cord-259748-x7dq1sy4	521	43	receptor	receptor	NN
cord-259748-x7dq1sy4	521	44	that	that	WDT
cord-259748-x7dq1sy4	521	45	activates	activate	VBZ
cord-259748-x7dq1sy4	521	46	Type	type	NN
cord-259748-x7dq1sy4	521	47	I	-PRON-	PRP
cord-259748-x7dq1sy4	521	48	interferon	interferon	NN
cord-259748-x7dq1sy4	521	49	Non	non	JJ
cord-259748-x7dq1sy4	521	50	-	-	JJ
cord-259748-x7dq1sy4	521	51	canonical	canonical	JJ
cord-259748-x7dq1sy4	521	52	activation	activation	NN
cord-259748-x7dq1sy4	521	53	of	of	IN
cord-259748-x7dq1sy4	521	54	the	the	DT
cord-259748-x7dq1sy4	521	55	DNA	dna	NN
cord-259748-x7dq1sy4	521	56	sensing	sensing	NN
cord-259748-x7dq1sy4	521	57	adaptor	adaptor	NN
cord-259748-x7dq1sy4	521	58	STING	sting	NN
cord-259748-x7dq1sy4	521	59	by	by	IN
cord-259748-x7dq1sy4	521	60	ATM	atm	NN
cord-259748-x7dq1sy4	521	61	and	and	CC
cord-259748-x7dq1sy4	521	62	IFI16	ifi16	NN
cord-259748-x7dq1sy4	521	63	mediates	mediate	VBZ
cord-259748-x7dq1sy4	522	1	NF	NF	NNP
cord-259748-x7dq1sy4	522	2	-	-	HYPH
cord-259748-x7dq1sy4	522	3	kappaB	kappaB	NNP
cord-259748-x7dq1sy4	522	4	signaling	signal	VBG
cord-259748-x7dq1sy4	522	5	after	after	IN
cord-259748-x7dq1sy4	522	6	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	522	7	DNA	dna	NN
cord-259748-x7dq1sy4	522	8	damage	damage	NN
cord-259748-x7dq1sy4	523	1	Nuclear	nuclear	JJ
cord-259748-x7dq1sy4	523	2	IFI16	ifi16	NN
cord-259748-x7dq1sy4	523	3	induction	induction	NN
cord-259748-x7dq1sy4	523	4	of	of	IN
cord-259748-x7dq1sy4	523	5	IRF-3	IRF-3	NNP
cord-259748-x7dq1sy4	523	6	signaling	signal	VBG
cord-259748-x7dq1sy4	523	7	during	during	IN
cord-259748-x7dq1sy4	523	8	herpesviral	herpesviral	JJ
cord-259748-x7dq1sy4	523	9	infection	infection	NN
cord-259748-x7dq1sy4	523	10	and	and	CC
cord-259748-x7dq1sy4	523	11	degradation	degradation	NN
cord-259748-x7dq1sy4	523	12	of	of	IN
cord-259748-x7dq1sy4	523	13	IFI16	ifi16	NN
cord-259748-x7dq1sy4	523	14	by	by	IN
cord-259748-x7dq1sy4	523	15	the	the	DT
cord-259748-x7dq1sy4	523	16	viral	viral	JJ
cord-259748-x7dq1sy4	523	17	ICP0	ICP0	NNP
cord-259748-x7dq1sy4	523	18	protein	protein	NN
cord-259748-x7dq1sy4	523	19	IFI16	ifi16	NN
cord-259748-x7dq1sy4	523	20	is	be	VBZ
cord-259748-x7dq1sy4	523	21	required	require	VBN
cord-259748-x7dq1sy4	523	22	for	for	IN
cord-259748-x7dq1sy4	523	23	DNA	dna	NN
cord-259748-x7dq1sy4	523	24	sensing	sensing	NN
cord-259748-x7dq1sy4	523	25	in	in	IN
cord-259748-x7dq1sy4	523	26	human	human	JJ
cord-259748-x7dq1sy4	523	27	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	523	28	by	by	IN
cord-259748-x7dq1sy4	523	29	promoting	promote	VBG
cord-259748-x7dq1sy4	523	30	production	production	NN
cord-259748-x7dq1sy4	523	31	and	and	CC
cord-259748-x7dq1sy4	523	32	function	function	NN
cord-259748-x7dq1sy4	523	33	of	of	IN
cord-259748-x7dq1sy4	523	34	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	523	35	IFI16	ifi16	NN
cord-259748-x7dq1sy4	523	36	and	and	CC
cord-259748-x7dq1sy4	523	37	cGAS	cgas	NN
cord-259748-x7dq1sy4	523	38	cooperate	cooperate	VB
cord-259748-x7dq1sy4	523	39	in	in	IN
cord-259748-x7dq1sy4	523	40	the	the	DT
cord-259748-x7dq1sy4	523	41	activation	activation	NN
cord-259748-x7dq1sy4	523	42	of	of	IN
cord-259748-x7dq1sy4	523	43	STING	sting	NN
cord-259748-x7dq1sy4	523	44	during	during	IN
cord-259748-x7dq1sy4	523	45	DNA	dna	NN
cord-259748-x7dq1sy4	523	46	sensing	sensing	NN
cord-259748-x7dq1sy4	523	47	in	in	IN
cord-259748-x7dq1sy4	523	48	human	human	JJ
cord-259748-x7dq1sy4	523	49	keratinocytes	keratinocyte	NNS
cord-259748-x7dq1sy4	523	50	cGAS	cgas	NN
cord-259748-x7dq1sy4	523	51	-	-	HYPH
cord-259748-x7dq1sy4	523	52	mediated	mediate	VBN
cord-259748-x7dq1sy4	523	53	stabilization	stabilization	NN
cord-259748-x7dq1sy4	523	54	of	of	IN
cord-259748-x7dq1sy4	523	55	IFI16	IFI16	NNP
cord-259748-x7dq1sy4	523	56	promotes	promote	VBZ
cord-259748-x7dq1sy4	523	57	innate	innate	VBP
cord-259748-x7dq1sy4	523	58	signaling	signaling	NN
cord-259748-x7dq1sy4	523	59	during	during	IN
cord-259748-x7dq1sy4	523	60	herpes	herpes	NNP
cord-259748-x7dq1sy4	523	61	simplex	simplex	NNP
cord-259748-x7dq1sy4	523	62	virus	virus	NN
cord-259748-x7dq1sy4	523	63	infection	infection	NN
cord-259748-x7dq1sy4	523	64	Viral	Viral	NNP
cord-259748-x7dq1sy4	523	65	DNA	DNA	NNP
cord-259748-x7dq1sy4	523	66	sensors	sensor	NNS
cord-259748-x7dq1sy4	523	67	IFI16	ifi16	VBP
cord-259748-x7dq1sy4	523	68	and	and	CC
cord-259748-x7dq1sy4	523	69	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	523	70	GMP	GMP	NNP
cord-259748-x7dq1sy4	523	71	-	-	HYPH
cord-259748-x7dq1sy4	523	72	AMP	AMP	NNP
cord-259748-x7dq1sy4	523	73	synthase	synthase	NN
cord-259748-x7dq1sy4	523	74	possess	possess	VBP
cord-259748-x7dq1sy4	523	75	distinct	distinct	JJ
cord-259748-x7dq1sy4	523	76	functions	function	NNS
cord-259748-x7dq1sy4	523	77	in	in	IN
cord-259748-x7dq1sy4	523	78	regulating	regulate	VBG
cord-259748-x7dq1sy4	523	79	viral	viral	JJ
cord-259748-x7dq1sy4	523	80	gene	gene	NN
cord-259748-x7dq1sy4	523	81	expression	expression	NN
cord-259748-x7dq1sy4	523	82	,	,	,
cord-259748-x7dq1sy4	523	83	immune	immune	JJ
cord-259748-x7dq1sy4	523	84	defenses	defense	NNS
cord-259748-x7dq1sy4	523	85	,	,	,
cord-259748-x7dq1sy4	523	86	and	and	CC
cord-259748-x7dq1sy4	523	87	apoptotic	apoptotic	JJ
cord-259748-x7dq1sy4	523	88	responses	response	NNS
cord-259748-x7dq1sy4	523	89	during	during	IN
cord-259748-x7dq1sy4	523	90	herpesvirus	herpesvirus	NN
cord-259748-x7dq1sy4	523	91	infection	infection	NN
cord-259748-x7dq1sy4	523	92	STING	sting	NN
cord-259748-x7dq1sy4	523	93	-	-	HYPH
cord-259748-x7dq1sy4	523	94	mediated	mediate	VBN
cord-259748-x7dq1sy4	523	95	IFI16	ifi16	NN
cord-259748-x7dq1sy4	523	96	degradation	degradation	NN
cord-259748-x7dq1sy4	524	1	negatively	negatively	RB
cord-259748-x7dq1sy4	524	2	controls	control	VBZ
cord-259748-x7dq1sy4	525	1	Type	type	NN
cord-259748-x7dq1sy4	525	2	I	-PRON-	PRP
cord-259748-x7dq1sy4	525	3	interferon	interferon	VBD
cord-259748-x7dq1sy4	525	4	production	production	NN
cord-259748-x7dq1sy4	525	5	Assembly	assembly	NN
cord-259748-x7dq1sy4	525	6	and	and	CC
cord-259748-x7dq1sy4	525	7	localization	localization	NN
cord-259748-x7dq1sy4	525	8	of	of	IN
cord-259748-x7dq1sy4	525	9	Toll	Toll	NNP
cord-259748-x7dq1sy4	525	10	-	-	HYPH
cord-259748-x7dq1sy4	525	11	like	like	JJ
cord-259748-x7dq1sy4	525	12	receptor	receptor	NN
cord-259748-x7dq1sy4	525	13	signalling	signal	VBG
cord-259748-x7dq1sy4	525	14	complexes	complex	NNS
cord-259748-x7dq1sy4	525	15	STING	sting	NN
cord-259748-x7dq1sy4	525	16	requires	require	VBZ
cord-259748-x7dq1sy4	525	17	the	the	DT
cord-259748-x7dq1sy4	525	18	adaptor	adaptor	NN
cord-259748-x7dq1sy4	525	19	TRIF	TRIF	NNP
cord-259748-x7dq1sy4	525	20	to	to	TO
cord-259748-x7dq1sy4	525	21	trigger	trigger	VB
cord-259748-x7dq1sy4	525	22	innate	innate	JJ
cord-259748-x7dq1sy4	525	23	immune	immune	JJ
cord-259748-x7dq1sy4	525	24	responses	response	NNS
cord-259748-x7dq1sy4	525	25	to	to	IN
cord-259748-x7dq1sy4	525	26	microbial	microbial	JJ
cord-259748-x7dq1sy4	525	27	infection	infection	NN
cord-259748-x7dq1sy4	525	28	Sequential	sequential	JJ
cord-259748-x7dq1sy4	525	29	activation	activation	NN
cord-259748-x7dq1sy4	525	30	of	of	IN
cord-259748-x7dq1sy4	525	31	two	two	CD
cord-259748-x7dq1sy4	525	32	pathogen	pathogen	NN
cord-259748-x7dq1sy4	525	33	-	-	HYPH
cord-259748-x7dq1sy4	525	34	sensing	sense	VBG
cord-259748-x7dq1sy4	525	35	pathways	pathway	NNS
cord-259748-x7dq1sy4	525	36	required	require	VBN
cord-259748-x7dq1sy4	525	37	for	for	IN
cord-259748-x7dq1sy4	526	1	Type	type	NN
cord-259748-x7dq1sy4	526	2	I	-PRON-	PRP
cord-259748-x7dq1sy4	526	3	Interferon	Interferon	NNP
cord-259748-x7dq1sy4	526	4	expression	expression	NN
cord-259748-x7dq1sy4	526	5	and	and	CC
cord-259748-x7dq1sy4	526	6	resistance	resistance	NN
cord-259748-x7dq1sy4	526	7	to	to	IN
cord-259748-x7dq1sy4	526	8	an	an	DT
cord-259748-x7dq1sy4	526	9	acute	acute	JJ
cord-259748-x7dq1sy4	526	10	DNA	dna	NN
cord-259748-x7dq1sy4	526	11	virus	virus	NN
cord-259748-x7dq1sy4	526	12	infection	infection	NN
cord-259748-x7dq1sy4	526	13	Cross	Cross	NNP
cord-259748-x7dq1sy4	526	14	-	-	NN
cord-259748-x7dq1sy4	526	15	regulation	regulation	NN
cord-259748-x7dq1sy4	526	16	of	of	IN
cord-259748-x7dq1sy4	527	1	two	two	CD
cord-259748-x7dq1sy4	527	2	Type	type	NN
cord-259748-x7dq1sy4	527	3	I	-PRON-	PRP
cord-259748-x7dq1sy4	527	4	interferon	interferon	NN
cord-259748-x7dq1sy4	527	5	signaling	signal	VBG
cord-259748-x7dq1sy4	527	6	pathways	pathway	NNS
cord-259748-x7dq1sy4	527	7	in	in	IN
cord-259748-x7dq1sy4	527	8	plasmacytoid	plasmacytoid	NNP
cord-259748-x7dq1sy4	527	9	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	527	10	cells	cell	NNS
cord-259748-x7dq1sy4	527	11	controls	control	VBZ
cord-259748-x7dq1sy4	527	12	anti	anti	JJ
cord-259748-x7dq1sy4	527	13	-	-	JJ
cord-259748-x7dq1sy4	527	14	malaria	malaria	JJ
cord-259748-x7dq1sy4	527	15	immunity	immunity	NN
cord-259748-x7dq1sy4	527	16	and	and	CC
cord-259748-x7dq1sy4	527	17	host	host	NN
cord-259748-x7dq1sy4	527	18	mortality	mortality	NN
cord-259748-x7dq1sy4	527	19	Oxidative	oxidative	JJ
cord-259748-x7dq1sy4	527	20	damage	damage	NN
cord-259748-x7dq1sy4	527	21	of	of	IN
cord-259748-x7dq1sy4	527	22	DNA	dna	NN
cord-259748-x7dq1sy4	527	23	confers	confer	VBZ
cord-259748-x7dq1sy4	527	24	resistance	resistance	NN
cord-259748-x7dq1sy4	527	25	to	to	IN
cord-259748-x7dq1sy4	527	26	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	527	27	nuclease	nuclease	FW
cord-259748-x7dq1sy4	527	28	TREX1	TREX1	NNP
cord-259748-x7dq1sy4	527	29	degradation	degradation	NN
cord-259748-x7dq1sy4	527	30	and	and	CC
cord-259748-x7dq1sy4	527	31	potentiates	potentiate	VBZ
cord-259748-x7dq1sy4	527	32	STING	sting	NN
cord-259748-x7dq1sy4	527	33	-	-	HYPH
cord-259748-x7dq1sy4	527	34	dependent	dependent	JJ
cord-259748-x7dq1sy4	527	35	immune	immune	JJ
cord-259748-x7dq1sy4	527	36	sensing	sensing	NN
cord-259748-x7dq1sy4	527	37	Mitochondria	mitochondria	NN
cord-259748-x7dq1sy4	527	38	and	and	CC
cord-259748-x7dq1sy4	527	39	cell	cell	NN
cord-259748-x7dq1sy4	527	40	death	death	NN
cord-259748-x7dq1sy4	527	41	:	:	:
cord-259748-x7dq1sy4	527	42	outer	outer	JJ
cord-259748-x7dq1sy4	527	43	membrane	membrane	NN
cord-259748-x7dq1sy4	527	44	permeabilization	permeabilization	NN
cord-259748-x7dq1sy4	527	45	and	and	CC
cord-259748-x7dq1sy4	527	46	beyond	beyond	IN
cord-259748-x7dq1sy4	527	47	Mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	527	48	inner	inner	JJ
cord-259748-x7dq1sy4	527	49	membrane	membrane	NN
cord-259748-x7dq1sy4	527	50	permeabilisation	permeabilisation	NN
cord-259748-x7dq1sy4	527	51	enables	enable	VBZ
cord-259748-x7dq1sy4	527	52	mtDNA	mtdna	NN
cord-259748-x7dq1sy4	527	53	release	release	NN
cord-259748-x7dq1sy4	527	54	during	during	IN
cord-259748-x7dq1sy4	527	55	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	527	56	Apoptotic	Apoptotic	NNP
cord-259748-x7dq1sy4	527	57	caspases	caspase	NNS
cord-259748-x7dq1sy4	527	58	prevent	prevent	VBP
cord-259748-x7dq1sy4	527	59	the	the	DT
cord-259748-x7dq1sy4	527	60	induction	induction	NN
cord-259748-x7dq1sy4	527	61	of	of	IN
cord-259748-x7dq1sy4	527	62	Type	type	NN
cord-259748-x7dq1sy4	527	63	I	-PRON-	PRP
cord-259748-x7dq1sy4	527	64	interferons	interferon	NNS
cord-259748-x7dq1sy4	527	65	by	by	IN
cord-259748-x7dq1sy4	527	66	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	527	67	DNA	DNA	NNP
cord-259748-x7dq1sy4	527	68	Apoptotic	Apoptotic	NNP
cord-259748-x7dq1sy4	527	69	caspases	caspase	NNS
cord-259748-x7dq1sy4	527	70	suppress	suppress	VBP
cord-259748-x7dq1sy4	527	71	Type	type	NN
cord-259748-x7dq1sy4	527	72	I	-PRON-	PRP
cord-259748-x7dq1sy4	527	73	interferon	interferon	VBD
cord-259748-x7dq1sy4	527	74	production	production	NN
cord-259748-x7dq1sy4	527	75	via	via	IN
cord-259748-x7dq1sy4	527	76	the	the	DT
cord-259748-x7dq1sy4	527	77	cleavage	cleavage	NN
cord-259748-x7dq1sy4	527	78	of	of	IN
cord-259748-x7dq1sy4	527	79	cGAS	cgas	NN
cord-259748-x7dq1sy4	527	80	,	,	,
cord-259748-x7dq1sy4	527	81	MAVS	mavs	UH
cord-259748-x7dq1sy4	527	82	,	,	,
cord-259748-x7dq1sy4	527	83	and	and	CC
cord-259748-x7dq1sy4	527	84	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	528	1	Signalling	signalling	NN
cord-259748-x7dq1sy4	528	2	strength	strength	NN
cord-259748-x7dq1sy4	528	3	determines	determine	VBZ
cord-259748-x7dq1sy4	528	4	proapoptotic	proapoptotic	JJ
cord-259748-x7dq1sy4	528	5	functions	function	NNS
cord-259748-x7dq1sy4	528	6	of	of	IN
cord-259748-x7dq1sy4	528	7	STING	STING	NNP
cord-259748-x7dq1sy4	528	8	PUMA	PUMA	NNP
cord-259748-x7dq1sy4	528	9	amplifies	amplify	VBZ
cord-259748-x7dq1sy4	528	10	necroptosis	necroptosis	NN
cord-259748-x7dq1sy4	528	11	signaling	signal	VBG
cord-259748-x7dq1sy4	528	12	by	by	IN
cord-259748-x7dq1sy4	528	13	activating	activate	VBG
cord-259748-x7dq1sy4	528	14	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	528	15	DNA	dna	NN
cord-259748-x7dq1sy4	528	16	sensors	sensor	NNS
cord-259748-x7dq1sy4	528	17	Autophagic	Autophagic	NNP
cord-259748-x7dq1sy4	528	18	cell	cell	NN
cord-259748-x7dq1sy4	528	19	death	death	NN
cord-259748-x7dq1sy4	528	20	restricts	restrict	VBZ
cord-259748-x7dq1sy4	528	21	chromosomal	chromosomal	JJ
cord-259748-x7dq1sy4	528	22	instability	instability	NN
cord-259748-x7dq1sy4	528	23	during	during	IN
cord-259748-x7dq1sy4	528	24	replicative	replicative	JJ
cord-259748-x7dq1sy4	528	25	crisis	crisis	NN
cord-259748-x7dq1sy4	528	26	Induction	Induction	NNP
cord-259748-x7dq1sy4	528	27	of	of	IN
cord-259748-x7dq1sy4	528	28	necroptotic	necroptotic	JJ
cord-259748-x7dq1sy4	528	29	cell	cell	NN
cord-259748-x7dq1sy4	528	30	death	death	NN
cord-259748-x7dq1sy4	528	31	by	by	IN
cord-259748-x7dq1sy4	528	32	viral	viral	JJ
cord-259748-x7dq1sy4	528	33	activation	activation	NN
cord-259748-x7dq1sy4	528	34	of	of	IN
cord-259748-x7dq1sy4	528	35	the	the	DT
cord-259748-x7dq1sy4	528	36	RIG	rig	NN
cord-259748-x7dq1sy4	528	37	-	-	:
cord-259748-x7dq1sy4	528	38	I	-PRON-	PRP
cord-259748-x7dq1sy4	528	39	or	or	CC
cord-259748-x7dq1sy4	528	40	STING	sting	VB
cord-259748-x7dq1sy4	528	41	pathway	pathway	NN
cord-259748-x7dq1sy4	528	42	TNFalpha	TNFalpha	NNS
cord-259748-x7dq1sy4	528	43	and	and	CC
cord-259748-x7dq1sy4	528	44	radioresistant	radioresistant	NN
cord-259748-x7dq1sy4	528	45	stromal	stromal	NN
cord-259748-x7dq1sy4	528	46	cells	cell	NNS
cord-259748-x7dq1sy4	528	47	are	be	VBP
cord-259748-x7dq1sy4	528	48	essential	essential	JJ
cord-259748-x7dq1sy4	528	49	for	for	IN
cord-259748-x7dq1sy4	528	50	therapeutic	therapeutic	JJ
cord-259748-x7dq1sy4	528	51	efficacy	efficacy	NN
cord-259748-x7dq1sy4	528	52	of	of	IN
cord-259748-x7dq1sy4	528	53	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	528	54	dinucleotide	dinucleotide	NN
cord-259748-x7dq1sy4	528	55	STING	STING	NNP
cord-259748-x7dq1sy4	528	56	agonists	agonist	NNS
cord-259748-x7dq1sy4	528	57	in	in	IN
cord-259748-x7dq1sy4	528	58	nonimmunogenic	nonimmunogenic	NNP
cord-259748-x7dq1sy4	528	59	tumors	tumor	NNS
cord-259748-x7dq1sy4	528	60	Cellular	cellular	JJ
cord-259748-x7dq1sy4	528	61	senescence	senescence	NN
cord-259748-x7dq1sy4	528	62	:	:	:
cord-259748-x7dq1sy4	529	1	aging	age	VBG
cord-259748-x7dq1sy4	529	2	p16INK4a	p16INK4a	NNP
cord-259748-x7dq1sy4	529	3	induces	induce	VBZ
cord-259748-x7dq1sy4	529	4	an	an	DT
cord-259748-x7dq1sy4	529	5	age	age	NN
cord-259748-x7dq1sy4	529	6	-	-	HYPH
cord-259748-x7dq1sy4	529	7	dependent	dependent	JJ
cord-259748-x7dq1sy4	529	8	decline	decline	NN
cord-259748-x7dq1sy4	529	9	in	in	IN
cord-259748-x7dq1sy4	529	10	islet	islet	NN
cord-259748-x7dq1sy4	529	11	regenerative	regenerative	JJ
cord-259748-x7dq1sy4	529	12	potential	potential	JJ
cord-259748-x7dq1sy4	529	13	Autophagy	Autophagy	NNP
cord-259748-x7dq1sy4	529	14	mediates	mediate	VBZ
cord-259748-x7dq1sy4	529	15	degradation	degradation	NN
cord-259748-x7dq1sy4	529	16	of	of	IN
cord-259748-x7dq1sy4	529	17	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	529	18	lamina	lamina	JJ
cord-259748-x7dq1sy4	529	19	Extranuclear	Extranuclear	NNP
cord-259748-x7dq1sy4	529	20	DNA	DNA	NNP
cord-259748-x7dq1sy4	529	21	accumulates	accumulate	VBZ
cord-259748-x7dq1sy4	529	22	in	in	IN
cord-259748-x7dq1sy4	529	23	aged	aged	JJ
cord-259748-x7dq1sy4	529	24	cells	cell	NNS
cord-259748-x7dq1sy4	529	25	and	and	CC
cord-259748-x7dq1sy4	529	26	contributes	contribute	VBZ
cord-259748-x7dq1sy4	529	27	to	to	TO
cord-259748-x7dq1sy4	529	28	senescence	senescence	NN
cord-259748-x7dq1sy4	529	29	and	and	CC
cord-259748-x7dq1sy4	529	30	inflammation	inflammation	NN
cord-259748-x7dq1sy4	529	31	Senescenceassociated	senescenceassociate	VBN
cord-259748-x7dq1sy4	529	32	secretory	secretory	JJ
cord-259748-x7dq1sy4	529	33	phenotypes	phenotype	NNS
cord-259748-x7dq1sy4	529	34	reveal	reveal	VBP
cord-259748-x7dq1sy4	529	35	cell	cell	NN
cord-259748-x7dq1sy4	529	36	-	-	HYPH
cord-259748-x7dq1sy4	529	37	nonautonomous	nonautonomous	JJ
cord-259748-x7dq1sy4	529	38	functions	function	NNS
cord-259748-x7dq1sy4	529	39	of	of	IN
cord-259748-x7dq1sy4	529	40	oncogenic	oncogenic	JJ
cord-259748-x7dq1sy4	529	41	RAS	RAS	NNP
cord-259748-x7dq1sy4	529	42	and	and	CC
cord-259748-x7dq1sy4	529	43	the	the	DT
cord-259748-x7dq1sy4	529	44	p53	p53	NN
cord-259748-x7dq1sy4	529	45	tumor	tumor	NN
cord-259748-x7dq1sy4	529	46	suppressor	suppressor	NN
cord-259748-x7dq1sy4	529	47	Cytoplasmic	Cytoplasmic	NNP
cord-259748-x7dq1sy4	529	48	chromatin	chromatin	NN
cord-259748-x7dq1sy4	529	49	triggers	trigger	VBZ
cord-259748-x7dq1sy4	529	50	inflammation	inflammation	NN
cord-259748-x7dq1sy4	529	51	in	in	IN
cord-259748-x7dq1sy4	529	52	senescence	senescence	NN
cord-259748-x7dq1sy4	529	53	and	and	CC
cord-259748-x7dq1sy4	529	54	cancer	cancer	NN
cord-259748-x7dq1sy4	529	55	Downregulation	Downregulation	NNP
cord-259748-x7dq1sy4	529	56	of	of	IN
cord-259748-x7dq1sy4	529	57	cytoplasmic	cytoplasmic	JJ
cord-259748-x7dq1sy4	529	58	DNases	DNases	NNPS
cord-259748-x7dq1sy4	529	59	is	be	VBZ
cord-259748-x7dq1sy4	529	60	implicated	implicate	VBN
cord-259748-x7dq1sy4	529	61	in	in	IN
cord-259748-x7dq1sy4	529	62	cytoplasmic	cytoplasmic	JJ
cord-259748-x7dq1sy4	529	63	DNA	dna	NN
cord-259748-x7dq1sy4	529	64	accumulation	accumulation	NN
cord-259748-x7dq1sy4	529	65	and	and	CC
cord-259748-x7dq1sy4	529	66	SASP	SASP	NNP
cord-259748-x7dq1sy4	529	67	in	in	IN
cord-259748-x7dq1sy4	529	68	senescent	senescent	JJ
cord-259748-x7dq1sy4	529	69	cells	cell	NNS
cord-259748-x7dq1sy4	530	1	Innate	innate	JJ
cord-259748-x7dq1sy4	530	2	immune	immune	JJ
cord-259748-x7dq1sy4	530	3	sensing	sensing	NN
cord-259748-x7dq1sy4	530	4	of	of	IN
cord-259748-x7dq1sy4	530	5	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	530	6	chromatin	chromatin	NN
cord-259748-x7dq1sy4	530	7	fragments	fragment	NNS
cord-259748-x7dq1sy4	530	8	through	through	IN
cord-259748-x7dq1sy4	530	9	cGAS	cgas	NN
cord-259748-x7dq1sy4	530	10	promotes	promote	NNS
cord-259748-x7dq1sy4	531	1	senescence	senescence	NN
cord-259748-x7dq1sy4	531	2	cGAS	cgas	NN
cord-259748-x7dq1sy4	531	3	is	be	VBZ
cord-259748-x7dq1sy4	531	4	essential	essential	JJ
cord-259748-x7dq1sy4	531	5	for	for	IN
cord-259748-x7dq1sy4	531	6	cellular	cellular	JJ
cord-259748-x7dq1sy4	531	7	senescence	senescence	NN
cord-259748-x7dq1sy4	531	8	DNA	dna	NN
cord-259748-x7dq1sy4	531	9	-	-	HYPH
cord-259748-x7dq1sy4	531	10	damage	damage	NN
cord-259748-x7dq1sy4	531	11	-	-	HYPH
cord-259748-x7dq1sy4	531	12	induced	induce	VBN
cord-259748-x7dq1sy4	531	13	type	type	NN
cord-259748-x7dq1sy4	532	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	532	2	interferon	interferon	RB
cord-259748-x7dq1sy4	532	3	promotes	promote	VBZ
cord-259748-x7dq1sy4	532	4	senescence	senescence	NN
cord-259748-x7dq1sy4	532	5	and	and	CC
cord-259748-x7dq1sy4	532	6	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	532	7	stem	stem	NN
cord-259748-x7dq1sy4	532	8	cell	cell	NN
cord-259748-x7dq1sy4	532	9	function	function	NN
cord-259748-x7dq1sy4	533	1	Bacterial	bacterial	JJ
cord-259748-x7dq1sy4	533	2	c	c	NN
cord-259748-x7dq1sy4	533	3	-	-	HYPH
cord-259748-x7dq1sy4	533	4	di	di	FW
cord-259748-x7dq1sy4	533	5	-	-	HYPH
cord-259748-x7dq1sy4	533	6	GMP	GMP	NNP
cord-259748-x7dq1sy4	533	7	affects	affect	VBZ
cord-259748-x7dq1sy4	533	8	hematopoietic	hematopoietic	JJ
cord-259748-x7dq1sy4	533	9	stem	stem	NN
cord-259748-x7dq1sy4	533	10	/	/	SYM
cord-259748-x7dq1sy4	533	11	progenitors	progenitor	NNS
cord-259748-x7dq1sy4	533	12	and	and	CC
cord-259748-x7dq1sy4	533	13	their	-PRON-	PRP$
cord-259748-x7dq1sy4	533	14	niches	niche	NNS
cord-259748-x7dq1sy4	533	15	through	through	IN
cord-259748-x7dq1sy4	533	16	STING	sting	NN
cord-259748-x7dq1sy4	534	1	A	a	DT
cord-259748-x7dq1sy4	534	2	circular	circular	JJ
cord-259748-x7dq1sy4	534	3	RNA	rna	NN
cord-259748-x7dq1sy4	534	4	protects	protect	VBZ
cord-259748-x7dq1sy4	534	5	dormant	dormant	JJ
cord-259748-x7dq1sy4	534	6	hematopoietic	hematopoietic	JJ
cord-259748-x7dq1sy4	534	7	stem	stem	NN
cord-259748-x7dq1sy4	534	8	cells	cell	NNS
cord-259748-x7dq1sy4	534	9	from	from	IN
cord-259748-x7dq1sy4	534	10	DNA	dna	NN
cord-259748-x7dq1sy4	534	11	sensor	sensor	NN
cord-259748-x7dq1sy4	534	12	cGAS	cgas	NN
cord-259748-x7dq1sy4	534	13	-	-	HYPH
cord-259748-x7dq1sy4	534	14	mediated	mediate	VBN
cord-259748-x7dq1sy4	534	15	exhaustion	exhaustion	NN
cord-259748-x7dq1sy4	534	16	PQBP1	PQBP1	NNS
cord-259748-x7dq1sy4	535	1	Is	be	VBZ
cord-259748-x7dq1sy4	535	2	a	a	DT
cord-259748-x7dq1sy4	535	3	proximal	proximal	JJ
cord-259748-x7dq1sy4	535	4	sensor	sensor	NN
cord-259748-x7dq1sy4	535	5	of	of	IN
cord-259748-x7dq1sy4	535	6	the	the	DT
cord-259748-x7dq1sy4	535	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	535	8	-	-	HYPH
cord-259748-x7dq1sy4	535	9	dependent	dependent	JJ
cord-259748-x7dq1sy4	535	10	innate	innate	JJ
cord-259748-x7dq1sy4	535	11	response	response	NN
cord-259748-x7dq1sy4	535	12	to	to	IN
cord-259748-x7dq1sy4	535	13	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	535	14	NONO	NONO	NNP
cord-259748-x7dq1sy4	535	15	detects	detect	VBZ
cord-259748-x7dq1sy4	535	16	the	the	DT
cord-259748-x7dq1sy4	535	17	nuclear	nuclear	JJ
cord-259748-x7dq1sy4	535	18	HIV	HIV	NNP
cord-259748-x7dq1sy4	535	19	capsid	capsid	NN
cord-259748-x7dq1sy4	535	20	to	to	TO
cord-259748-x7dq1sy4	535	21	promote	promote	VB
cord-259748-x7dq1sy4	536	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	536	2	-	-	HYPH
cord-259748-x7dq1sy4	536	3	mediated	mediate	VBN
cord-259748-x7dq1sy4	536	4	innate	innate	JJ
cord-259748-x7dq1sy4	536	5	immune	immune	JJ
cord-259748-x7dq1sy4	536	6	activation	activation	NN
cord-259748-x7dq1sy4	536	7	p53	p53	NN
cord-259748-x7dq1sy4	536	8	induces	induce	VBZ
cord-259748-x7dq1sy4	536	9	formation	formation	NN
cord-259748-x7dq1sy4	536	10	of	of	IN
cord-259748-x7dq1sy4	536	11	NEAT1	NEAT1	NNP
cord-259748-x7dq1sy4	536	12	lncRNA	lncRNA	NNP
cord-259748-x7dq1sy4	536	13	-	-	HYPH
cord-259748-x7dq1sy4	536	14	containing	contain	VBG
cord-259748-x7dq1sy4	536	15	paraspeckles	paraspeckle	NNS
cord-259748-x7dq1sy4	536	16	that	that	WDT
cord-259748-x7dq1sy4	536	17	modulate	modulate	VBP
cord-259748-x7dq1sy4	536	18	replication	replication	NN
cord-259748-x7dq1sy4	536	19	stress	stress	NN
cord-259748-x7dq1sy4	536	20	response	response	NN
cord-259748-x7dq1sy4	536	21	and	and	CC
cord-259748-x7dq1sy4	536	22	chemosensitivity	chemosensitivity	NN
cord-259748-x7dq1sy4	536	23	HEXIM1	HEXIM1	VBD
cord-259748-x7dq1sy4	536	24	and	and	CC
cord-259748-x7dq1sy4	536	25	NEAT1	NEAT1	VBN
cord-259748-x7dq1sy4	536	26	long	long	JJ
cord-259748-x7dq1sy4	536	27	non	non	JJ
cord-259748-x7dq1sy4	536	28	-	-	JJ
cord-259748-x7dq1sy4	536	29	coding	code	VBG
cord-259748-x7dq1sy4	536	30	RNA	RNA	NNP
cord-259748-x7dq1sy4	536	31	form	form	NN
cord-259748-x7dq1sy4	536	32	a	a	DT
cord-259748-x7dq1sy4	536	33	multi	multi	JJ
cord-259748-x7dq1sy4	536	34	-	-	JJ
cord-259748-x7dq1sy4	536	35	subunit	subunit	JJ
cord-259748-x7dq1sy4	536	36	complex	complex	NN
cord-259748-x7dq1sy4	536	37	that	that	WDT
cord-259748-x7dq1sy4	536	38	regulates	regulate	VBZ
cord-259748-x7dq1sy4	536	39	DNA	dna	NN
cord-259748-x7dq1sy4	536	40	-	-	HYPH
cord-259748-x7dq1sy4	536	41	mediated	mediate	VBN
cord-259748-x7dq1sy4	536	42	innate	innate	JJ
cord-259748-x7dq1sy4	536	43	immune	immune	JJ
cord-259748-x7dq1sy4	536	44	response	response	NN
cord-259748-x7dq1sy4	537	1	STINGdependent	STINGdependent	NNP
cord-259748-x7dq1sy4	537	2	translation	translation	NN
cord-259748-x7dq1sy4	537	3	inhibition	inhibition	NN
cord-259748-x7dq1sy4	537	4	restricts	restrict	VBZ
cord-259748-x7dq1sy4	537	5	RNA	RNA	NNP
cord-259748-x7dq1sy4	537	6	virus	virus	NN
cord-259748-x7dq1sy4	537	7	replication	replication	NN
cord-259748-x7dq1sy4	537	8	Inhibition	inhibition	NN
cord-259748-x7dq1sy4	537	9	of	of	IN
cord-259748-x7dq1sy4	537	10	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	537	11	disease	disease	NN
cord-259748-x7dq1sy4	537	12	progression	progression	NN
cord-259748-x7dq1sy4	537	13	by	by	IN
cord-259748-x7dq1sy4	537	14	contemporaneous	contemporaneous	JJ
cord-259748-x7dq1sy4	537	15	HIV-2	HIV-2	NNP
cord-259748-x7dq1sy4	537	16	infection	infection	NN
cord-259748-x7dq1sy4	537	17	SAMHD1	SAMHD1	NNPS
cord-259748-x7dq1sy4	538	1	is	be	VBZ
cord-259748-x7dq1sy4	538	2	the	the	DT
cord-259748-x7dq1sy4	538	3	dendritic	dendritic	NN
cord-259748-x7dq1sy4	538	4	-	-	HYPH
cord-259748-x7dq1sy4	538	5	and	and	CC
cord-259748-x7dq1sy4	538	6	myeloid	myeloid	JJ
cord-259748-x7dq1sy4	538	7	-	-	HYPH
cord-259748-x7dq1sy4	538	8	cell	cell	NN
cord-259748-x7dq1sy4	538	9	-	-	HYPH
cord-259748-x7dq1sy4	538	10	specific	specific	JJ
cord-259748-x7dq1sy4	538	11	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	538	12	restriction	restriction	NN
cord-259748-x7dq1sy4	538	13	factor	factor	NN
cord-259748-x7dq1sy4	538	14	counteracted	counteract	VBN
cord-259748-x7dq1sy4	538	15	by	by	IN
cord-259748-x7dq1sy4	538	16	Vpx	Vpx	NNP
cord-259748-x7dq1sy4	538	17	Reshaping	Reshaping	NNP
cord-259748-x7dq1sy4	538	18	of	of	IN
cord-259748-x7dq1sy4	538	19	the	the	DT
cord-259748-x7dq1sy4	538	20	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	538	21	cell	cell	NN
cord-259748-x7dq1sy4	538	22	chromatin	chromatin	NN
cord-259748-x7dq1sy4	538	23	landscape	landscape	NN
cord-259748-x7dq1sy4	538	24	and	and	CC
cord-259748-x7dq1sy4	538	25	interferon	interferon	NN
cord-259748-x7dq1sy4	538	26	pathways	pathway	NNS
cord-259748-x7dq1sy4	538	27	during	during	IN
cord-259748-x7dq1sy4	538	28	HIV	HIV	NNP
cord-259748-x7dq1sy4	538	29	infection	infection	NN
cord-259748-x7dq1sy4	539	1	The	the	DT
cord-259748-x7dq1sy4	539	2	capsids	capsid	NNS
cord-259748-x7dq1sy4	539	3	of	of	IN
cord-259748-x7dq1sy4	539	4	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	539	5	and	and	CC
cord-259748-x7dq1sy4	539	6	HIV-2	HIV-2	NNP
cord-259748-x7dq1sy4	539	7	determine	determine	VB
cord-259748-x7dq1sy4	539	8	immune	immune	JJ
cord-259748-x7dq1sy4	539	9	detection	detection	NN
cord-259748-x7dq1sy4	539	10	of	of	IN
cord-259748-x7dq1sy4	539	11	the	the	DT
cord-259748-x7dq1sy4	539	12	viral	viral	JJ
cord-259748-x7dq1sy4	539	13	cDNA	cdna	NN
cord-259748-x7dq1sy4	539	14	by	by	IN
cord-259748-x7dq1sy4	539	15	the	the	DT
cord-259748-x7dq1sy4	539	16	innate	innate	JJ
cord-259748-x7dq1sy4	539	17	sensor	sensor	NN
cord-259748-x7dq1sy4	539	18	cGAS	cgas	NN
cord-259748-x7dq1sy4	539	19	in	in	IN
cord-259748-x7dq1sy4	539	20	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	539	21	cells	cell	NNS
cord-259748-x7dq1sy4	539	22	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	539	23	activation	activation	NN
cord-259748-x7dq1sy4	539	24	of	of	IN
cord-259748-x7dq1sy4	539	25	innate	innate	JJ
cord-259748-x7dq1sy4	539	26	immunity	immunity	NN
cord-259748-x7dq1sy4	539	27	depends	depend	VBZ
cord-259748-x7dq1sy4	539	28	strongly	strongly	RB
cord-259748-x7dq1sy4	539	29	on	on	IN
cord-259748-x7dq1sy4	539	30	the	the	DT
cord-259748-x7dq1sy4	539	31	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	539	32	level	level	NN
cord-259748-x7dq1sy4	539	33	of	of	IN
cord-259748-x7dq1sy4	539	34	TREX1	trex1	NN
cord-259748-x7dq1sy4	539	35	and	and	CC
cord-259748-x7dq1sy4	539	36	sensing	sensing	NN
cord-259748-x7dq1sy4	539	37	of	of	IN
cord-259748-x7dq1sy4	539	38	incomplete	incomplete	JJ
cord-259748-x7dq1sy4	539	39	reverse	reverse	NN
cord-259748-x7dq1sy4	539	40	transcription	transcription	NN
cord-259748-x7dq1sy4	539	41	products	product	NNS
cord-259748-x7dq1sy4	539	42	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	539	43	uses	use	VBZ
cord-259748-x7dq1sy4	539	44	dynamic	dynamic	JJ
cord-259748-x7dq1sy4	539	45	capsid	capsid	NN
cord-259748-x7dq1sy4	539	46	pores	pore	VBZ
cord-259748-x7dq1sy4	539	47	to	to	TO
cord-259748-x7dq1sy4	539	48	import	import	VB
cord-259748-x7dq1sy4	539	49	nucleotides	nucleotide	NNS
cord-259748-x7dq1sy4	539	50	and	and	CC
cord-259748-x7dq1sy4	539	51	fuel	fuel	NN
cord-259748-x7dq1sy4	539	52	encapsidated	encapsidate	VBN
cord-259748-x7dq1sy4	539	53	DNA	DNA	NNP
cord-259748-x7dq1sy4	539	54	synthesis	synthesis	NN
cord-259748-x7dq1sy4	539	55	Restriction	restriction	NN
cord-259748-x7dq1sy4	539	56	of	of	IN
cord-259748-x7dq1sy4	539	57	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	539	58	and	and	CC
cord-259748-x7dq1sy4	539	59	other	other	JJ
cord-259748-x7dq1sy4	539	60	retroviruses	retrovirus	NNS
cord-259748-x7dq1sy4	539	61	by	by	IN
cord-259748-x7dq1sy4	539	62	TRIM5	TRIM5	NNP
cord-259748-x7dq1sy4	539	63	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	539	64	evades	evade	VBZ
cord-259748-x7dq1sy4	539	65	innate	innate	JJ
cord-259748-x7dq1sy4	539	66	immune	immune	JJ
cord-259748-x7dq1sy4	539	67	recognition	recognition	NN
cord-259748-x7dq1sy4	539	68	through	through	IN
cord-259748-x7dq1sy4	539	69	specific	specific	JJ
cord-259748-x7dq1sy4	539	70	cofactor	cofactor	NN
cord-259748-x7dq1sy4	539	71	recruitment	recruitment	NN
cord-259748-x7dq1sy4	539	72	Cyclic	Cyclic	NNP
cord-259748-x7dq1sy4	539	73	di	di	NNP
cord-259748-x7dq1sy4	539	74	-	-	HYPH
cord-259748-x7dq1sy4	539	75	GMP	GMP	NNP
cord-259748-x7dq1sy4	539	76	:	:	:
cord-259748-x7dq1sy4	540	1	second	second	JJ
cord-259748-x7dq1sy4	540	2	messenger	messenger	NN
cord-259748-x7dq1sy4	540	3	extraordinaire	extraordinaire	NN
cord-259748-x7dq1sy4	540	4	Cyclic	Cyclic	NNP
cord-259748-x7dq1sy4	540	5	GMP	GMP	NNP
cord-259748-x7dq1sy4	540	6	-	-	HYPH
cord-259748-x7dq1sy4	540	7	AMP	AMP	NNP
cord-259748-x7dq1sy4	540	8	signalling	signalling	NN
cord-259748-x7dq1sy4	540	9	protects	protect	VBZ
cord-259748-x7dq1sy4	540	10	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	540	11	against	against	IN
cord-259748-x7dq1sy4	540	12	viral	viral	JJ
cord-259748-x7dq1sy4	540	13	infection	infection	NN
cord-259748-x7dq1sy4	541	1	A	a	DT
cord-259748-x7dq1sy4	541	2	bacterial	bacterial	JJ
cord-259748-x7dq1sy4	541	3	cyclic	cyclic	NN
cord-259748-x7dq1sy4	541	4	dinucleotide	dinucleotide	NN
cord-259748-x7dq1sy4	541	5	activates	activate	VBZ
cord-259748-x7dq1sy4	541	6	the	the	DT
cord-259748-x7dq1sy4	541	7	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	541	8	surveillance	surveillance	NN
cord-259748-x7dq1sy4	541	9	pathway	pathway	NN
cord-259748-x7dq1sy4	541	10	and	and	CC
cord-259748-x7dq1sy4	541	11	mediates	mediate	VBZ
cord-259748-x7dq1sy4	541	12	innate	innate	JJ
cord-259748-x7dq1sy4	541	13	resistance	resistance	NN
cord-259748-x7dq1sy4	541	14	to	to	IN
cord-259748-x7dq1sy4	541	15	tuberculosis	tuberculosis	NN
cord-259748-x7dq1sy4	541	16	Tuberculosis	Tuberculosis	NNP
cord-259748-x7dq1sy4	541	17	pathogenesis	pathogenesis	NN
cord-259748-x7dq1sy4	541	18	and	and	CC
cord-259748-x7dq1sy4	541	19	immunity	immunity	NN
cord-259748-x7dq1sy4	541	20	Mycobacterium	Mycobacterium	NNP
cord-259748-x7dq1sy4	541	21	tuberculosis	tuberculosis	NN
cord-259748-x7dq1sy4	542	1	differentially	differentially	RB
cord-259748-x7dq1sy4	542	2	activates	activate	VBZ
cord-259748-x7dq1sy4	542	3	cGAS	cga	VBN
cord-259748-x7dq1sy4	542	4	-	-	:
cord-259748-x7dq1sy4	542	5	and	and	CC
cord-259748-x7dq1sy4	542	6	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	542	7	-	-	HYPH
cord-259748-x7dq1sy4	542	8	dependent	dependent	JJ
cord-259748-x7dq1sy4	542	9	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	542	10	immune	immune	JJ
cord-259748-x7dq1sy4	542	11	responses	response	NNS
cord-259748-x7dq1sy4	542	12	through	through	IN
cord-259748-x7dq1sy4	542	13	ESX-1	ESX-1	NNP
cord-259748-x7dq1sy4	542	14	Brucella	Brucella	NNP
cord-259748-x7dq1sy4	542	15	abortus	abortus	NN
cord-259748-x7dq1sy4	543	1	triggers	trigger	VBZ
cord-259748-x7dq1sy4	543	2	a	a	DT
cord-259748-x7dq1sy4	543	3	cGAS	cgas	JJ
cord-259748-x7dq1sy4	543	4	-	-	HYPH
cord-259748-x7dq1sy4	543	5	independent	independent	JJ
cord-259748-x7dq1sy4	543	6	STING	sting	NN
cord-259748-x7dq1sy4	543	7	pathway	pathway	NN
cord-259748-x7dq1sy4	543	8	to	to	TO
cord-259748-x7dq1sy4	543	9	induce	induce	VB
cord-259748-x7dq1sy4	543	10	host	host	NN
cord-259748-x7dq1sy4	543	11	protection	protection	NN
cord-259748-x7dq1sy4	543	12	that	that	WDT
cord-259748-x7dq1sy4	543	13	involves	involve	VBZ
cord-259748-x7dq1sy4	543	14	guanylate	guanylate	NN
cord-259748-x7dq1sy4	543	15	-	-	HYPH
cord-259748-x7dq1sy4	543	16	binding	bind	VBG
cord-259748-x7dq1sy4	543	17	proteins	protein	NNS
cord-259748-x7dq1sy4	543	18	and	and	CC
cord-259748-x7dq1sy4	543	19	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	543	20	activation	activation	NN
cord-259748-x7dq1sy4	543	21	Beneficial	beneficial	JJ
cord-259748-x7dq1sy4	543	22	effects	effect	NNS
cord-259748-x7dq1sy4	543	23	of	of	IN
cord-259748-x7dq1sy4	543	24	Yogasanas	Yogasanas	NNP
cord-259748-x7dq1sy4	543	25	and	and	CC
cord-259748-x7dq1sy4	543	26	Pranayama	Pranayama	NNP
cord-259748-x7dq1sy4	543	27	in	in	IN
cord-259748-x7dq1sy4	543	28	limiting	limit	VBG
cord-259748-x7dq1sy4	543	29	the	the	DT
cord-259748-x7dq1sy4	543	30	cognitive	cognitive	JJ
cord-259748-x7dq1sy4	543	31	decline	decline	NN
cord-259748-x7dq1sy4	543	32	in	in	IN
cord-259748-x7dq1sy4	543	33	Type	Type	NNP
cord-259748-x7dq1sy4	543	34	2	2	CD
cord-259748-x7dq1sy4	543	35	Diabetes	Diabetes	NNP
cord-259748-x7dq1sy4	543	36	Group	Group	NNP
cord-259748-x7dq1sy4	543	37	B	B	NNP
cord-259748-x7dq1sy4	543	38	Streptococcus	streptococcus	NN
cord-259748-x7dq1sy4	544	1	degrades	degrade	VBZ
cord-259748-x7dq1sy4	544	2	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	544	3	-	-	HYPH
cord-259748-x7dq1sy4	544	4	di	di	FW
cord-259748-x7dq1sy4	544	5	-	-	HYPH
cord-259748-x7dq1sy4	544	6	AMP	amp	NN
cord-259748-x7dq1sy4	544	7	to	to	TO
cord-259748-x7dq1sy4	544	8	modulate	modulate	VB
cord-259748-x7dq1sy4	544	9	STINGdependent	stingdependent	NN
cord-259748-x7dq1sy4	544	10	Type	type	NN
cord-259748-x7dq1sy4	545	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	545	2	interferon	interferon	VBD
cord-259748-x7dq1sy4	545	3	production	production	NN
cord-259748-x7dq1sy4	545	4	Inhibition	inhibition	NN
cord-259748-x7dq1sy4	545	5	of	of	IN
cord-259748-x7dq1sy4	545	6	innate	innate	JJ
cord-259748-x7dq1sy4	545	7	immune	immune	JJ
cord-259748-x7dq1sy4	545	8	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	545	9	surveillance	surveillance	NN
cord-259748-x7dq1sy4	545	10	by	by	IN
cord-259748-x7dq1sy4	545	11	an	an	DT
cord-259748-x7dq1sy4	545	12	M.	M.	NNP
cord-259748-x7dq1sy4	545	13	tuberculosis	tuberculosis	NN
cord-259748-x7dq1sy4	545	14	phosphodiesterase	phosphodiesterase	NN
cord-259748-x7dq1sy4	545	15	Absence	absence	NN
cord-259748-x7dq1sy4	545	16	of	of	IN
cord-259748-x7dq1sy4	545	17	specific	specific	JJ
cord-259748-x7dq1sy4	545	18	Chlamydia	Chlamydia	NNP
cord-259748-x7dq1sy4	545	19	trachomatis	trachomatis	NN
cord-259748-x7dq1sy4	545	20	inclusion	inclusion	NN
cord-259748-x7dq1sy4	545	21	membrane	membrane	NN
cord-259748-x7dq1sy4	545	22	proteins	protein	NNS
cord-259748-x7dq1sy4	545	23	triggers	trigger	VBZ
cord-259748-x7dq1sy4	545	24	premature	premature	JJ
cord-259748-x7dq1sy4	545	25	inclusion	inclusion	NN
cord-259748-x7dq1sy4	545	26	membrane	membrane	NN
cord-259748-x7dq1sy4	545	27	lysis	lysis	NN
cord-259748-x7dq1sy4	545	28	and	and	CC
cord-259748-x7dq1sy4	545	29	host	host	NN
cord-259748-x7dq1sy4	545	30	cell	cell	NN
cord-259748-x7dq1sy4	545	31	death	death	NN
cord-259748-x7dq1sy4	546	1	The	the	DT
cord-259748-x7dq1sy4	546	2	Chlamydia	Chlamydia	NNP
cord-259748-x7dq1sy4	546	3	trachomatis	trachomatis	NN
cord-259748-x7dq1sy4	546	4	inclusion	inclusion	NN
cord-259748-x7dq1sy4	546	5	membrane	membrane	NN
cord-259748-x7dq1sy4	546	6	protein	protein	NN
cord-259748-x7dq1sy4	547	1	CpoS	CpoS	NNP
cord-259748-x7dq1sy4	547	2	counteracts	counteract	VBZ
cord-259748-x7dq1sy4	547	3	STING	sting	NN
cord-259748-x7dq1sy4	547	4	-	-	HYPH
cord-259748-x7dq1sy4	547	5	mediated	mediate	VBN
cord-259748-x7dq1sy4	547	6	cellular	cellular	JJ
cord-259748-x7dq1sy4	547	7	surveillance	surveillance	NN
cord-259748-x7dq1sy4	547	8	and	and	CC
cord-259748-x7dq1sy4	547	9	suicide	suicide	NN
cord-259748-x7dq1sy4	547	10	programs	program	NNS
cord-259748-x7dq1sy4	547	11	Yersinia	Yersinia	NNP
cord-259748-x7dq1sy4	547	12	YopJ	YopJ	NNP
cord-259748-x7dq1sy4	547	13	negatively	negatively	RB
cord-259748-x7dq1sy4	547	14	regulates	regulate	VBZ
cord-259748-x7dq1sy4	547	15	IRF3-mediated	irf3-mediated	JJ
cord-259748-x7dq1sy4	547	16	antibacterial	antibacterial	JJ
cord-259748-x7dq1sy4	547	17	response	response	NN
cord-259748-x7dq1sy4	547	18	through	through	IN
cord-259748-x7dq1sy4	547	19	disruption	disruption	NN
cord-259748-x7dq1sy4	547	20	of	of	IN
cord-259748-x7dq1sy4	547	21	STING	sting	NN
cord-259748-x7dq1sy4	547	22	-	-	HYPH
cord-259748-x7dq1sy4	547	23	mediated	mediate	VBN
cord-259748-x7dq1sy4	547	24	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	547	25	DNA	dna	NN
cord-259748-x7dq1sy4	547	26	signaling	signal	VBG
cord-259748-x7dq1sy4	547	27	Intracellular	Intracellular	NNP
cord-259748-x7dq1sy4	547	28	bacteria	bacteria	NNS
cord-259748-x7dq1sy4	547	29	engage	engage	VB
cord-259748-x7dq1sy4	547	30	a	a	DT
cord-259748-x7dq1sy4	547	31	STING	sting	NN
cord-259748-x7dq1sy4	547	32	-	-	HYPH
cord-259748-x7dq1sy4	547	33	TBK1-MVB12b	tbk1-mvb12b	NN
cord-259748-x7dq1sy4	547	34	pathway	pathway	NN
cord-259748-x7dq1sy4	547	35	to	to	TO
cord-259748-x7dq1sy4	547	36	enable	enable	VB
cord-259748-x7dq1sy4	547	37	paracrine	paracrine	JJ
cord-259748-x7dq1sy4	547	38	cGAS	cgas	NN
cord-259748-x7dq1sy4	547	39	-	-	HYPH
cord-259748-x7dq1sy4	547	40	STING	sting	NN
cord-259748-x7dq1sy4	547	41	signalling	signal	VBG
cord-259748-x7dq1sy4	547	42	STING	sting	NN
cord-259748-x7dq1sy4	547	43	-	-	HYPH
cord-259748-x7dq1sy4	547	44	dependent	dependent	JJ
cord-259748-x7dq1sy4	547	45	type	type	NN
cord-259748-x7dq1sy4	548	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	548	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	548	3	production	production	NN
cord-259748-x7dq1sy4	548	4	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	548	5	cell	cell	NN
cord-259748-x7dq1sy4	548	6	-	-	HYPH
cord-259748-x7dq1sy4	548	7	mediated	mediate	VBN
cord-259748-x7dq1sy4	548	8	immunity	immunity	NN
cord-259748-x7dq1sy4	548	9	to	to	IN
cord-259748-x7dq1sy4	548	10	Listeria	Listeria	NNP
cord-259748-x7dq1sy4	548	11	monocytogenes	monocytogenes	NNP
cord-259748-x7dq1sy4	548	12	Induction	Induction	NNP
cord-259748-x7dq1sy4	548	13	of	of	IN
cord-259748-x7dq1sy4	548	14	interferon	interferon	NN
cord-259748-x7dq1sy4	548	15	-	-	HYPH
cord-259748-x7dq1sy4	548	16	stimulated	stimulate	VBN
cord-259748-x7dq1sy4	548	17	genes	gene	NNS
cord-259748-x7dq1sy4	548	18	by	by	IN
cord-259748-x7dq1sy4	548	19	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	548	20	promotes	promote	VBZ
cord-259748-x7dq1sy4	548	21	replication	replication	NN
cord-259748-x7dq1sy4	548	22	of	of	IN
cord-259748-x7dq1sy4	548	23	Toxoplasma	Toxoplasma	NNP
cord-259748-x7dq1sy4	548	24	gondii	gondii	NNP
cord-259748-x7dq1sy4	548	25	Malaria	Malaria	NNP
cord-259748-x7dq1sy4	548	26	parasite	parasite	NN
cord-259748-x7dq1sy4	548	27	DNA	dna	NN
cord-259748-x7dq1sy4	548	28	-	-	HYPH
cord-259748-x7dq1sy4	548	29	harbouring	harbour	VBG
cord-259748-x7dq1sy4	548	30	vesicles	vesicle	NNS
cord-259748-x7dq1sy4	548	31	activate	activate	VBP
cord-259748-x7dq1sy4	548	32	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	548	33	immune	immune	JJ
cord-259748-x7dq1sy4	548	34	sensors	sensor	NNS
cord-259748-x7dq1sy4	549	1	Type	type	NN
cord-259748-x7dq1sy4	550	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	550	2	interferon	interferon	VBD
cord-259748-x7dq1sy4	550	3	in	in	IN
cord-259748-x7dq1sy4	550	4	rheumatic	rheumatic	JJ
cord-259748-x7dq1sy4	550	5	diseases	disease	NNS
cord-259748-x7dq1sy4	550	6	Activated	activate	VBN
cord-259748-x7dq1sy4	550	7	STING	sting	NN
cord-259748-x7dq1sy4	550	8	in	in	IN
cord-259748-x7dq1sy4	550	9	a	a	DT
cord-259748-x7dq1sy4	550	10	vascular	vascular	JJ
cord-259748-x7dq1sy4	550	11	and	and	CC
cord-259748-x7dq1sy4	550	12	pulmonary	pulmonary	JJ
cord-259748-x7dq1sy4	550	13	syndrome	syndrome	NN
cord-259748-x7dq1sy4	551	1	Inherited	inherited	JJ
cord-259748-x7dq1sy4	551	2	STING	sting	NN
cord-259748-x7dq1sy4	551	3	-	-	HYPH
cord-259748-x7dq1sy4	551	4	activating	activate	VBG
cord-259748-x7dq1sy4	551	5	mutation	mutation	NN
cord-259748-x7dq1sy4	551	6	underlies	underlie	VBZ
cord-259748-x7dq1sy4	551	7	a	a	DT
cord-259748-x7dq1sy4	551	8	familial	familial	JJ
cord-259748-x7dq1sy4	551	9	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	551	10	syndrome	syndrome	NN
cord-259748-x7dq1sy4	551	11	with	with	IN
cord-259748-x7dq1sy4	551	12	lupus	lupus	NN
cord-259748-x7dq1sy4	551	13	-	-	HYPH
cord-259748-x7dq1sy4	551	14	like	like	JJ
cord-259748-x7dq1sy4	551	15	manifestations	manifestation	NNS
cord-259748-x7dq1sy4	551	16	Stimulator	Stimulator	NNP
cord-259748-x7dq1sy4	551	17	of	of	IN
cord-259748-x7dq1sy4	551	18	interferon	interferon	NN
cord-259748-x7dq1sy4	551	19	genes	gene	NNS
cord-259748-x7dq1sy4	551	20	-	-	:
cord-259748-x7dq1sy4	551	21	associated	associate	VBN
cord-259748-x7dq1sy4	551	22	vasculopathy	vasculopathy	NNP
cord-259748-x7dq1sy4	551	23	with	with	IN
cord-259748-x7dq1sy4	551	24	onset	onset	NN
cord-259748-x7dq1sy4	551	25	in	in	IN
cord-259748-x7dq1sy4	551	26	infancy	infancy	NN
cord-259748-x7dq1sy4	551	27	:	:	:
cord-259748-x7dq1sy4	551	28	a	a	DT
cord-259748-x7dq1sy4	551	29	mimic	mimic	NN
cord-259748-x7dq1sy4	551	30	of	of	IN
cord-259748-x7dq1sy4	551	31	childhood	childhood	NN
cord-259748-x7dq1sy4	551	32	Granulomatosis	Granulomatosis	NNP
cord-259748-x7dq1sy4	551	33	with	with	IN
cord-259748-x7dq1sy4	551	34	Polyangiitis	Polyangiitis	NNP
cord-259748-x7dq1sy4	551	35	Severe	severe	JJ
cord-259748-x7dq1sy4	551	36	combined	combine	VBN
cord-259748-x7dq1sy4	551	37	immunodeficiency	immunodeficiency	NN
cord-259748-x7dq1sy4	551	38	in	in	IN
cord-259748-x7dq1sy4	551	39	stimulator	stimulator	NN
cord-259748-x7dq1sy4	551	40	of	of	IN
cord-259748-x7dq1sy4	551	41	interferon	interferon	NN
cord-259748-x7dq1sy4	551	42	genes	gene	NNS
cord-259748-x7dq1sy4	551	43	(	(	-LRB-
cord-259748-x7dq1sy4	551	44	STING	sting	NN
cord-259748-x7dq1sy4	551	45	)	)	-RRB-
cord-259748-x7dq1sy4	551	46	V154M	V154M	NNP
cord-259748-x7dq1sy4	551	47	/	/	SYM
cord-259748-x7dq1sy4	551	48	wild	wild	JJ
cord-259748-x7dq1sy4	551	49	-	-	HYPH
cord-259748-x7dq1sy4	551	50	type	type	NN
cord-259748-x7dq1sy4	551	51	mice	mouse	NNS
cord-259748-x7dq1sy4	551	52	STING	sting	NN
cord-259748-x7dq1sy4	551	53	-	-	HYPH
cord-259748-x7dq1sy4	551	54	associated	associate	VBN
cord-259748-x7dq1sy4	551	55	vasculopathy	vasculopathy	NNP
cord-259748-x7dq1sy4	551	56	develops	develop	VBZ
cord-259748-x7dq1sy4	551	57	independently	independently	RB
cord-259748-x7dq1sy4	551	58	of	of	IN
cord-259748-x7dq1sy4	551	59	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	551	60	in	in	IN
cord-259748-x7dq1sy4	551	61	mice	mouse	NNS
cord-259748-x7dq1sy4	551	62	Disease	Disease	NNP
cord-259748-x7dq1sy4	551	63	-	-	HYPH
cord-259748-x7dq1sy4	551	64	associated	associate	VBN
cord-259748-x7dq1sy4	551	65	mutations	mutation	NNS
cord-259748-x7dq1sy4	551	66	identify	identify	VBP
cord-259748-x7dq1sy4	551	67	a	a	DT
cord-259748-x7dq1sy4	551	68	novel	novel	JJ
cord-259748-x7dq1sy4	551	69	region	region	NN
cord-259748-x7dq1sy4	551	70	in	in	IN
cord-259748-x7dq1sy4	551	71	human	human	JJ
cord-259748-x7dq1sy4	551	72	STING	sting	NN
cord-259748-x7dq1sy4	551	73	necessary	necessary	JJ
cord-259748-x7dq1sy4	551	74	for	for	IN
cord-259748-x7dq1sy4	551	75	the	the	DT
cord-259748-x7dq1sy4	551	76	control	control	NN
cord-259748-x7dq1sy4	551	77	of	of	IN
cord-259748-x7dq1sy4	551	78	type	type	NN
cord-259748-x7dq1sy4	552	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	552	2	interferon	interferon	RB
cord-259748-x7dq1sy4	552	3	signaling	signal	VBG
cord-259748-x7dq1sy4	552	4	Personalized	Personalized	NNP
cord-259748-x7dq1sy4	552	5	immunomonitoring	immunomonitoring	NN
cord-259748-x7dq1sy4	552	6	uncovers	uncover	VBZ
cord-259748-x7dq1sy4	552	7	molecular	molecular	JJ
cord-259748-x7dq1sy4	552	8	networks	network	NNS
cord-259748-x7dq1sy4	552	9	that	that	WDT
cord-259748-x7dq1sy4	552	10	stratify	stratify	VBP
cord-259748-x7dq1sy4	552	11	lupus	lupus	NN
cord-259748-x7dq1sy4	552	12	patients	patient	NNS
cord-259748-x7dq1sy4	552	13	Aicardi	Aicardi	NNP
cord-259748-x7dq1sy4	552	14	-	-	HYPH
cord-259748-x7dq1sy4	552	15	goutieres	goutieres	NNP
cord-259748-x7dq1sy4	552	16	syndrome	syndrome	NN
cord-259748-x7dq1sy4	552	17	and	and	CC
cord-259748-x7dq1sy4	552	18	the	the	DT
cord-259748-x7dq1sy4	552	19	type	type	NN
cord-259748-x7dq1sy4	552	20	I	-PRON-	PRP
cord-259748-x7dq1sy4	552	21	interferonopathies	interferonopathie	VBZ
cord-259748-x7dq1sy4	553	1	Apoptosisderived	apoptosisderived	JJ
cord-259748-x7dq1sy4	553	2	membrane	membrane	NN
cord-259748-x7dq1sy4	553	3	vesicles	vesicle	NNS
cord-259748-x7dq1sy4	553	4	drive	drive	VBP
cord-259748-x7dq1sy4	553	5	the	the	DT
cord-259748-x7dq1sy4	553	6	cGAS	cgas	JJ
cord-259748-x7dq1sy4	553	7	-	-	HYPH
cord-259748-x7dq1sy4	553	8	STING	sting	NN
cord-259748-x7dq1sy4	553	9	pathway	pathway	NN
cord-259748-x7dq1sy4	553	10	and	and	CC
cord-259748-x7dq1sy4	553	11	enhance	enhance	VB
cord-259748-x7dq1sy4	553	12	type	type	NN
cord-259748-x7dq1sy4	554	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	554	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	554	3	production	production	NN
cord-259748-x7dq1sy4	554	4	in	in	IN
cord-259748-x7dq1sy4	554	5	systemic	systemic	JJ
cord-259748-x7dq1sy4	554	6	lupus	lupus	NN
cord-259748-x7dq1sy4	554	7	erythematosus	erythematosu	VBZ
cord-259748-x7dq1sy4	554	8	Expression	expression	NN
cord-259748-x7dq1sy4	554	9	of	of	IN
cord-259748-x7dq1sy4	554	10	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	554	11	GMP	GMP	NNP
cord-259748-x7dq1sy4	554	12	-	-	HYPH
cord-259748-x7dq1sy4	554	13	AMP	AMP	NNP
cord-259748-x7dq1sy4	554	14	synthase	synthase	NN
cord-259748-x7dq1sy4	554	15	in	in	IN
cord-259748-x7dq1sy4	554	16	patients	patient	NNS
cord-259748-x7dq1sy4	554	17	with	with	IN
cord-259748-x7dq1sy4	554	18	systemic	systemic	JJ
cord-259748-x7dq1sy4	554	19	lupus	lupus	NN
cord-259748-x7dq1sy4	554	20	erythematosus	erythematosus	NN
cord-259748-x7dq1sy4	554	21	.	.	.
cord-259748-x7dq1sy4	555	1	Arthritis	Arthritis	NNP
cord-259748-x7dq1sy4	555	2	Rheumatol	Rheumatol	NNP
cord-259748-x7dq1sy4	556	1	The	the	DT
cord-259748-x7dq1sy4	556	2	role	role	NN
cord-259748-x7dq1sy4	556	3	of	of	IN
cord-259748-x7dq1sy4	556	4	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	556	5	cells	cell	NNS
cord-259748-x7dq1sy4	556	6	in	in	IN
cord-259748-x7dq1sy4	556	7	autoimmunity	autoimmunity	NN
cord-259748-x7dq1sy4	556	8	Human	human	JJ
cord-259748-x7dq1sy4	556	9	plasmacytoid	plasmacytoid	NN
cord-259748-x7dq1sy4	556	10	dentritic	dentritic	NN
cord-259748-x7dq1sy4	556	11	cells	cell	NNS
cord-259748-x7dq1sy4	556	12	elicit	elicit	VBP
cord-259748-x7dq1sy4	556	13	a	a	DT
cord-259748-x7dq1sy4	556	14	Type	type	NN
cord-259748-x7dq1sy4	556	15	I	-PRON-	PRP
cord-259748-x7dq1sy4	556	16	interferon	interferon	NN
cord-259748-x7dq1sy4	556	17	response	response	NN
cord-259748-x7dq1sy4	556	18	by	by	IN
cord-259748-x7dq1sy4	556	19	sensing	sense	VBG
cord-259748-x7dq1sy4	556	20	DNA	dna	NN
cord-259748-x7dq1sy4	556	21	via	via	IN
cord-259748-x7dq1sy4	556	22	the	the	DT
cord-259748-x7dq1sy4	556	23	cGAS	cgas	NN
cord-259748-x7dq1sy4	556	24	-	-	HYPH
cord-259748-x7dq1sy4	556	25	STING	sting	NN
cord-259748-x7dq1sy4	556	26	signaling	signal	VBG
cord-259748-x7dq1sy4	556	27	pathway	pathway	NN
cord-259748-x7dq1sy4	557	1	Interferon	interferon	NN
cord-259748-x7dq1sy4	557	2	priming	priming	NN
cord-259748-x7dq1sy4	557	3	is	be	VBZ
cord-259748-x7dq1sy4	557	4	essential	essential	JJ
cord-259748-x7dq1sy4	557	5	for	for	IN
cord-259748-x7dq1sy4	557	6	human	human	JJ
cord-259748-x7dq1sy4	557	7	CD34	CD34	NNP
cord-259748-x7dq1sy4	557	8	+	+	CC
cord-259748-x7dq1sy4	557	9	cell	cell	NN
cord-259748-x7dq1sy4	557	10	-	-	HYPH
cord-259748-x7dq1sy4	557	11	derived	derive	VBN
cord-259748-x7dq1sy4	557	12	plasmacytoid	plasmacytoid	NNP
cord-259748-x7dq1sy4	557	13	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	557	14	cell	cell	NN
cord-259748-x7dq1sy4	557	15	maturation	maturation	NN
cord-259748-x7dq1sy4	557	16	and	and	CC
cord-259748-x7dq1sy4	557	17	function	function	NN
cord-259748-x7dq1sy4	558	1	Interleukin-1beta	Interleukin-1beta	NNP
cord-259748-x7dq1sy4	558	2	induces	induce	VBZ
cord-259748-x7dq1sy4	558	3	mtDNA	mtDNA	NNP
cord-259748-x7dq1sy4	558	4	release	release	NN
cord-259748-x7dq1sy4	558	5	to	to	TO
cord-259748-x7dq1sy4	558	6	activate	activate	VB
cord-259748-x7dq1sy4	558	7	innate	innate	JJ
cord-259748-x7dq1sy4	558	8	immune	immune	JJ
cord-259748-x7dq1sy4	558	9	signaling	signaling	NN
cord-259748-x7dq1sy4	558	10	via	via	IN
cord-259748-x7dq1sy4	558	11	cGAS	cgas	JJ
cord-259748-x7dq1sy4	558	12	-	-	HYPH
cord-259748-x7dq1sy4	558	13	STING	sting	NN
cord-259748-x7dq1sy4	558	14	Induction	induction	NN
cord-259748-x7dq1sy4	558	15	of	of	IN
cord-259748-x7dq1sy4	558	16	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	558	17	cell	cell	NN
cord-259748-x7dq1sy4	558	18	differentiation	differentiation	NN
cord-259748-x7dq1sy4	558	19	by	by	IN
cord-259748-x7dq1sy4	558	20	IFN	IFN	NNP
cord-259748-x7dq1sy4	558	21	-	-	HYPH
cord-259748-x7dq1sy4	558	22	alpha	alpha	NN
cord-259748-x7dq1sy4	558	23	in	in	IN
cord-259748-x7dq1sy4	558	24	systemic	systemic	JJ
cord-259748-x7dq1sy4	558	25	lupus	lupus	NN
cord-259748-x7dq1sy4	558	26	erythematosus	erythematosus	NN
cord-259748-x7dq1sy4	558	27	Neutrophil	Neutrophil	NNP
cord-259748-x7dq1sy4	558	28	extracellular	extracellular	JJ
cord-259748-x7dq1sy4	558	29	traps	trap	NNS
cord-259748-x7dq1sy4	558	30	enriched	enrich	VBN
cord-259748-x7dq1sy4	558	31	in	in	IN
cord-259748-x7dq1sy4	558	32	oxidized	oxidize	VBN
cord-259748-x7dq1sy4	558	33	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	558	34	DNA	dna	NN
cord-259748-x7dq1sy4	558	35	are	be	VBP
cord-259748-x7dq1sy4	558	36	interferogenic	interferogenic	JJ
cord-259748-x7dq1sy4	558	37	and	and	CC
cord-259748-x7dq1sy4	558	38	contribute	contribute	VB
cord-259748-x7dq1sy4	558	39	to	to	IN
cord-259748-x7dq1sy4	558	40	lupus	lupus	NN
cord-259748-x7dq1sy4	558	41	-	-	HYPH
cord-259748-x7dq1sy4	558	42	like	like	JJ
cord-259748-x7dq1sy4	558	43	disease	disease	NN
cord-259748-x7dq1sy4	558	44	Netting	Netting	NNP
cord-259748-x7dq1sy4	558	45	neutrophils	neutrophil	NNS
cord-259748-x7dq1sy4	559	1	are	be	VBP
cord-259748-x7dq1sy4	559	2	major	major	JJ
cord-259748-x7dq1sy4	559	3	inducers	inducer	NNS
cord-259748-x7dq1sy4	559	4	of	of	IN
cord-259748-x7dq1sy4	559	5	type	type	NN
cord-259748-x7dq1sy4	560	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	560	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	560	3	production	production	NN
cord-259748-x7dq1sy4	560	4	in	in	IN
cord-259748-x7dq1sy4	560	5	pediatric	pediatric	JJ
cord-259748-x7dq1sy4	560	6	systemic	systemic	JJ
cord-259748-x7dq1sy4	560	7	lupus	lupus	NN
cord-259748-x7dq1sy4	561	1	erythematosus	erythematosus	NNP
cord-259748-x7dq1sy4	561	2	Type	type	NN
cord-259748-x7dq1sy4	562	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	562	2	IFNrelated	ifnrelate	VBD
cord-259748-x7dq1sy4	562	3	NETosis	NETosis	NNP
cord-259748-x7dq1sy4	562	4	in	in	IN
cord-259748-x7dq1sy4	562	5	ataxia	ataxia	NN
cord-259748-x7dq1sy4	562	6	telangiectasia	telangiectasia	NNP
cord-259748-x7dq1sy4	562	7	and	and	CC
cord-259748-x7dq1sy4	562	8	Artemis	Artemis	NNP
cord-259748-x7dq1sy4	562	9	deficiency	deficiency	NN
cord-259748-x7dq1sy4	563	1	Cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	563	2	DNA	DNA	NNP
cord-259748-x7dq1sy4	563	3	sensing	sensing	NN
cord-259748-x7dq1sy4	563	4	promotes	promote	VBZ
cord-259748-x7dq1sy4	563	5	macrophage	macrophage	NN
cord-259748-x7dq1sy4	563	6	transformation	transformation	NN
cord-259748-x7dq1sy4	563	7	and	and	CC
cord-259748-x7dq1sy4	563	8	governs	govern	VBZ
cord-259748-x7dq1sy4	563	9	myocardial	myocardial	JJ
cord-259748-x7dq1sy4	563	10	ischemic	ischemic	JJ
cord-259748-x7dq1sy4	563	11	injury	injury	NN
cord-259748-x7dq1sy4	563	12	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	563	13	and	and	CC
cord-259748-x7dq1sy4	563	14	type	type	NN
cord-259748-x7dq1sy4	563	15	I	-PRON-	PRP
cord-259748-x7dq1sy4	563	16	interferons	interferon	NNS
cord-259748-x7dq1sy4	563	17	fuel	fuel	VBP
cord-259748-x7dq1sy4	563	18	a	a	DT
cord-259748-x7dq1sy4	563	19	fatal	fatal	JJ
cord-259748-x7dq1sy4	563	20	response	response	NN
cord-259748-x7dq1sy4	563	21	to	to	IN
cord-259748-x7dq1sy4	563	22	myocardial	myocardial	JJ
cord-259748-x7dq1sy4	563	23	infarction	infarction	NN
cord-259748-x7dq1sy4	563	24	Activation	activation	NN
cord-259748-x7dq1sy4	563	25	of	of	IN
cord-259748-x7dq1sy4	563	26	the	the	DT
cord-259748-x7dq1sy4	563	27	STING	sting	NN
cord-259748-x7dq1sy4	563	28	-	-	HYPH
cord-259748-x7dq1sy4	563	29	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	563	30	pathway	pathway	NN
cord-259748-x7dq1sy4	563	31	promotes	promote	VBZ
cord-259748-x7dq1sy4	563	32	hepatocyte	hepatocyte	NN
cord-259748-x7dq1sy4	563	33	inflammation	inflammation	NN
cord-259748-x7dq1sy4	563	34	,	,	,
cord-259748-x7dq1sy4	563	35	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	563	36	and	and	CC
cord-259748-x7dq1sy4	563	37	induces	induce	VBZ
cord-259748-x7dq1sy4	563	38	metabolic	metabolic	JJ
cord-259748-x7dq1sy4	563	39	disorders	disorder	NNS
cord-259748-x7dq1sy4	563	40	in	in	IN
cord-259748-x7dq1sy4	563	41	nonalcoholic	nonalcoholic	JJ
cord-259748-x7dq1sy4	563	42	fatty	fatty	JJ
cord-259748-x7dq1sy4	563	43	liver	liver	NN
cord-259748-x7dq1sy4	563	44	disease	disease	NN
cord-259748-x7dq1sy4	563	45	Expression	expression	NN
cord-259748-x7dq1sy4	563	46	of	of	IN
cord-259748-x7dq1sy4	563	47	STING	sting	NN
cord-259748-x7dq1sy4	563	48	Is	be	VBZ
cord-259748-x7dq1sy4	563	49	increased	increase	VBN
cord-259748-x7dq1sy4	563	50	in	in	IN
cord-259748-x7dq1sy4	563	51	liver	liver	NN
cord-259748-x7dq1sy4	563	52	tissues	tissue	NNS
cord-259748-x7dq1sy4	563	53	from	from	IN
cord-259748-x7dq1sy4	563	54	patients	patient	NNS
cord-259748-x7dq1sy4	563	55	with	with	IN
cord-259748-x7dq1sy4	563	56	NAFLD	NAFLD	NNP
cord-259748-x7dq1sy4	563	57	and	and	CC
cord-259748-x7dq1sy4	563	58	promotes	promote	VBZ
cord-259748-x7dq1sy4	563	59	macrophage	macrophage	NN
cord-259748-x7dq1sy4	563	60	-	-	HYPH
cord-259748-x7dq1sy4	563	61	mediated	mediate	VBN
cord-259748-x7dq1sy4	563	62	hepatic	hepatic	JJ
cord-259748-x7dq1sy4	563	63	inflammation	inflammation	NN
cord-259748-x7dq1sy4	563	64	and	and	CC
cord-259748-x7dq1sy4	563	65	fibrosis	fibrosis	NN
cord-259748-x7dq1sy4	563	66	in	in	IN
cord-259748-x7dq1sy4	563	67	mice	mouse	NNS
cord-259748-x7dq1sy4	563	68	STING	sting	NN
cord-259748-x7dq1sy4	563	69	-	-	HYPH
cord-259748-x7dq1sy4	563	70	mediated	mediate	VBN
cord-259748-x7dq1sy4	563	71	inflammation	inflammation	NN
cord-259748-x7dq1sy4	563	72	in	in	IN
cord-259748-x7dq1sy4	563	73	Kupffer	Kupffer	NNP
cord-259748-x7dq1sy4	563	74	cells	cell	NNS
cord-259748-x7dq1sy4	563	75	contributes	contribute	VBZ
cord-259748-x7dq1sy4	563	76	to	to	IN
cord-259748-x7dq1sy4	563	77	progression	progression	NN
cord-259748-x7dq1sy4	563	78	of	of	IN
cord-259748-x7dq1sy4	563	79	nonalcoholic	nonalcoholic	JJ
cord-259748-x7dq1sy4	563	80	steatohepatitis	steatohepatitis	NN
cord-259748-x7dq1sy4	564	1	Lipotoxicity	Lipotoxicity	NNP
cord-259748-x7dq1sy4	564	2	induces	induce	VBZ
cord-259748-x7dq1sy4	564	3	hepatic	hepatic	JJ
cord-259748-x7dq1sy4	564	4	protein	protein	NN
cord-259748-x7dq1sy4	564	5	inclusions	inclusion	NNS
cord-259748-x7dq1sy4	564	6	through	through	IN
cord-259748-x7dq1sy4	564	7	TANK	tank	NN
cord-259748-x7dq1sy4	564	8	binding	binding	NN
cord-259748-x7dq1sy4	564	9	kinase	kinase	NN
cord-259748-x7dq1sy4	564	10	1-mediated	1-mediated	CD
cord-259748-x7dq1sy4	565	1	p62	p62	NN
cord-259748-x7dq1sy4	565	2	/	/	SYM
cord-259748-x7dq1sy4	565	3	sequestosome	sequestosome	JJ
cord-259748-x7dq1sy4	565	4	1	1	CD
cord-259748-x7dq1sy4	565	5	phosphorylation	phosphorylation	NN
cord-259748-x7dq1sy4	565	6	STING	sting	NN
cord-259748-x7dq1sy4	565	7	-	-	HYPH
cord-259748-x7dq1sy4	565	8	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	565	9	Triggers	trigger	VBZ
cord-259748-x7dq1sy4	565	10	endothelial	endothelial	JJ
cord-259748-x7dq1sy4	565	11	inflammation	inflammation	NN
cord-259748-x7dq1sy4	565	12	in	in	IN
cord-259748-x7dq1sy4	565	13	response	response	NN
cord-259748-x7dq1sy4	565	14	to	to	TO
cord-259748-x7dq1sy4	565	15	free	free	VB
cord-259748-x7dq1sy4	565	16	fatty	fatty	JJ
cord-259748-x7dq1sy4	565	17	acid	acid	NN
cord-259748-x7dq1sy4	565	18	-	-	HYPH
cord-259748-x7dq1sy4	565	19	induced	induce	VBN
cord-259748-x7dq1sy4	565	20	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	565	21	damage	damage	NN
cord-259748-x7dq1sy4	565	22	in	in	IN
cord-259748-x7dq1sy4	565	23	diet	diet	NN
cord-259748-x7dq1sy4	565	24	-	-	HYPH
cord-259748-x7dq1sy4	565	25	induced	induce	VBN
cord-259748-x7dq1sy4	565	26	obesity	obesity	NN
cord-259748-x7dq1sy4	565	27	Priming	prime	VBG
cord-259748-x7dq1sy4	565	28	the	the	DT
cord-259748-x7dq1sy4	565	29	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	565	30	pump	pump	NN
cord-259748-x7dq1sy4	565	31	of	of	IN
cord-259748-x7dq1sy4	565	32	the	the	DT
cord-259748-x7dq1sy4	565	33	CNS	CNS	NNP
cord-259748-x7dq1sy4	565	34	after	after	IN
cord-259748-x7dq1sy4	565	35	traumatic	traumatic	JJ
cord-259748-x7dq1sy4	565	36	brain	brain	NN
cord-259748-x7dq1sy4	565	37	injury	injury	NN
cord-259748-x7dq1sy4	565	38	STINGmediated	stingmediate	VBD
cord-259748-x7dq1sy4	565	39	type	type	NN
cord-259748-x7dq1sy4	565	40	-	-	:
cord-259748-x7dq1sy4	565	41	I	-PRON-	PRP
cord-259748-x7dq1sy4	565	42	interferons	interferon	NNS
cord-259748-x7dq1sy4	565	43	contribute	contribute	VBP
cord-259748-x7dq1sy4	565	44	to	to	IN
cord-259748-x7dq1sy4	565	45	the	the	DT
cord-259748-x7dq1sy4	565	46	neuroinflammatory	neuroinflammatory	NN
cord-259748-x7dq1sy4	565	47	process	process	NN
cord-259748-x7dq1sy4	565	48	and	and	CC
cord-259748-x7dq1sy4	565	49	detrimental	detrimental	JJ
cord-259748-x7dq1sy4	565	50	effects	effect	NNS
cord-259748-x7dq1sy4	565	51	following	follow	VBG
cord-259748-x7dq1sy4	565	52	traumatic	traumatic	JJ
cord-259748-x7dq1sy4	565	53	brain	brain	NN
cord-259748-x7dq1sy4	565	54	injury	injury	NN
cord-259748-x7dq1sy4	565	55	STING	sting	NN
cord-259748-x7dq1sy4	565	56	-	-	HYPH
cord-259748-x7dq1sy4	565	57	dependent	dependent	JJ
cord-259748-x7dq1sy4	565	58	sensing	sensing	NN
cord-259748-x7dq1sy4	565	59	of	of	IN
cord-259748-x7dq1sy4	565	60	self	self	NN
cord-259748-x7dq1sy4	565	61	-	-	HYPH
cord-259748-x7dq1sy4	565	62	DNA	dna	NN
cord-259748-x7dq1sy4	565	63	drives	drive	NNS
cord-259748-x7dq1sy4	565	64	silica	silica	NN
cord-259748-x7dq1sy4	565	65	-	-	HYPH
cord-259748-x7dq1sy4	565	66	induced	induce	VBN
cord-259748-x7dq1sy4	565	67	lung	lung	NN
cord-259748-x7dq1sy4	565	68	inflammation	inflammation	NN
cord-259748-x7dq1sy4	565	69	Mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	565	70	damage	damage	NN
cord-259748-x7dq1sy4	565	71	and	and	CC
cord-259748-x7dq1sy4	565	72	activation	activation	NN
cord-259748-x7dq1sy4	565	73	of	of	IN
cord-259748-x7dq1sy4	565	74	the	the	DT
cord-259748-x7dq1sy4	565	75	STING	sting	NN
cord-259748-x7dq1sy4	565	76	pathway	pathway	NN
cord-259748-x7dq1sy4	565	77	lead	lead	NN
cord-259748-x7dq1sy4	565	78	to	to	IN
cord-259748-x7dq1sy4	565	79	renal	renal	JJ
cord-259748-x7dq1sy4	565	80	inflammation	inflammation	NN
cord-259748-x7dq1sy4	565	81	and	and	CC
cord-259748-x7dq1sy4	566	1	fibrosis	fibrosis	NN
cord-259748-x7dq1sy4	566	2	Mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	566	3	damage	damage	NN
cord-259748-x7dq1sy4	566	4	causes	cause	VBZ
cord-259748-x7dq1sy4	566	5	inflammation	inflammation	NN
cord-259748-x7dq1sy4	566	6	via	via	IN
cord-259748-x7dq1sy4	566	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	566	8	-	-	HYPH
cord-259748-x7dq1sy4	566	9	STING	sting	NN
cord-259748-x7dq1sy4	566	10	signaling	signaling	NN
cord-259748-x7dq1sy4	566	11	in	in	IN
cord-259748-x7dq1sy4	566	12	acute	acute	JJ
cord-259748-x7dq1sy4	566	13	kidney	kidney	NN
cord-259748-x7dq1sy4	566	14	injury	injury	NN
cord-259748-x7dq1sy4	567	1	How	how	WRB
cord-259748-x7dq1sy4	567	2	neuroinflammation	neuroinflammation	NN
cord-259748-x7dq1sy4	567	3	contributes	contribute	VBZ
cord-259748-x7dq1sy4	567	4	to	to	IN
cord-259748-x7dq1sy4	567	5	neurodegeneration	neurodegeneration	NN
cord-259748-x7dq1sy4	567	6	Sensing	sensing	NN
cord-259748-x7dq1sy4	567	7	of	of	IN
cord-259748-x7dq1sy4	567	8	HSV-1	hsv-1	NN
cord-259748-x7dq1sy4	567	9	by	by	IN
cord-259748-x7dq1sy4	567	10	the	the	DT
cord-259748-x7dq1sy4	567	11	cGAS	cgas	JJ
cord-259748-x7dq1sy4	567	12	-	-	HYPH
cord-259748-x7dq1sy4	567	13	STING	sting	NN
cord-259748-x7dq1sy4	567	14	pathway	pathway	NN
cord-259748-x7dq1sy4	567	15	in	in	IN
cord-259748-x7dq1sy4	567	16	microglia	microglia	NNP
cord-259748-x7dq1sy4	567	17	orchestrates	orchestrate	VBZ
cord-259748-x7dq1sy4	567	18	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	567	19	defence	defence	NN
cord-259748-x7dq1sy4	567	20	in	in	IN
cord-259748-x7dq1sy4	567	21	the	the	DT
cord-259748-x7dq1sy4	567	22	CNS	CNS	NNP
cord-259748-x7dq1sy4	567	23	Chronic	Chronic	NNP
cord-259748-x7dq1sy4	567	24	neurodegeneration	neurodegeneration	NN
cord-259748-x7dq1sy4	567	25	induces	induce	VBZ
cord-259748-x7dq1sy4	567	26	type	type	NN
cord-259748-x7dq1sy4	567	27	I	-PRON-	PRP
cord-259748-x7dq1sy4	567	28	interferon	interferon	VBD
cord-259748-x7dq1sy4	567	29	synthesis	synthesis	NN
cord-259748-x7dq1sy4	567	30	via	via	IN
cord-259748-x7dq1sy4	567	31	STING	sting	NN
cord-259748-x7dq1sy4	567	32	,	,	,
cord-259748-x7dq1sy4	567	33	shaping	shape	VBG
cord-259748-x7dq1sy4	567	34	microglial	microglial	JJ
cord-259748-x7dq1sy4	567	35	phenotype	phenotype	NN
cord-259748-x7dq1sy4	567	36	and	and	CC
cord-259748-x7dq1sy4	567	37	accelerating	accelerate	VBG
cord-259748-x7dq1sy4	567	38	disease	disease	NN
cord-259748-x7dq1sy4	567	39	progression	progression	NN
cord-259748-x7dq1sy4	568	1	The	the	DT
cord-259748-x7dq1sy4	568	2	roles	role	NNS
cord-259748-x7dq1sy4	568	3	of	of	IN
cord-259748-x7dq1sy4	568	4	PINK1	PINK1	NNP
cord-259748-x7dq1sy4	568	5	,	,	,
cord-259748-x7dq1sy4	568	6	parkin	parkin	NN
cord-259748-x7dq1sy4	568	7	,	,	,
cord-259748-x7dq1sy4	568	8	and	and	CC
cord-259748-x7dq1sy4	568	9	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	568	10	fidelity	fidelity	NN
cord-259748-x7dq1sy4	568	11	in	in	IN
cord-259748-x7dq1sy4	568	12	Parkinson	Parkinson	NNP
cord-259748-x7dq1sy4	568	13	's	's	POS
cord-259748-x7dq1sy4	568	14	disease	disease	NN
cord-259748-x7dq1sy4	568	15	Parkin	Parkin	NNP
cord-259748-x7dq1sy4	568	16	and	and	CC
cord-259748-x7dq1sy4	568	17	PINK1	PINK1	NNP
cord-259748-x7dq1sy4	568	18	mitigate	mitigate	VB
cord-259748-x7dq1sy4	568	19	STING	sting	NN
cord-259748-x7dq1sy4	568	20	-	-	HYPH
cord-259748-x7dq1sy4	568	21	induced	induce	VBN
cord-259748-x7dq1sy4	568	22	inflammation	inflammation	NN
cord-259748-x7dq1sy4	568	23	ATM	ATM	NNS
cord-259748-x7dq1sy4	568	24	and	and	CC
cord-259748-x7dq1sy4	568	25	the	the	DT
cord-259748-x7dq1sy4	568	26	molecular	molecular	JJ
cord-259748-x7dq1sy4	568	27	pathogenesis	pathogenesis	NN
cord-259748-x7dq1sy4	568	28	of	of	IN
cord-259748-x7dq1sy4	568	29	ataxia	ataxia	NN
cord-259748-x7dq1sy4	568	30	telangiectasia	telangiectasia	NNP
cord-259748-x7dq1sy4	568	31	Autoimmune	autoimmune	JJ
cord-259748-x7dq1sy4	568	32	phenomena	phenomenon	NNS
cord-259748-x7dq1sy4	568	33	in	in	IN
cord-259748-x7dq1sy4	568	34	ataxia	ataxia	NN
cord-259748-x7dq1sy4	568	35	telangiectasia	telangiectasia	NNP
cord-259748-x7dq1sy4	568	36	Mitochondrial	Mitochondrial	NNP
cord-259748-x7dq1sy4	568	37	DNA	DNA	NNP
cord-259748-x7dq1sy4	568	38	has	have	VBZ
cord-259748-x7dq1sy4	568	39	a	a	DT
cord-259748-x7dq1sy4	568	40	pro	pro	JJ
cord-259748-x7dq1sy4	568	41	-	-	JJ
cord-259748-x7dq1sy4	568	42	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	568	43	role	role	NN
cord-259748-x7dq1sy4	568	44	in	in	IN
cord-259748-x7dq1sy4	568	45	AMD	AMD	NNP
cord-259748-x7dq1sy4	568	46	cGAS	cgas	NN
cord-259748-x7dq1sy4	568	47	drives	drive	VBZ
cord-259748-x7dq1sy4	568	48	noncanonical	noncanonical	JJ
cord-259748-x7dq1sy4	568	49	-	-	HYPH
cord-259748-x7dq1sy4	568	50	inflammasome	inflammasome	NN
cord-259748-x7dq1sy4	568	51	activation	activation	NN
cord-259748-x7dq1sy4	568	52	in	in	IN
cord-259748-x7dq1sy4	568	53	age	age	NN
cord-259748-x7dq1sy4	568	54	-	-	HYPH
cord-259748-x7dq1sy4	568	55	related	relate	VBN
cord-259748-x7dq1sy4	568	56	macular	macular	JJ
cord-259748-x7dq1sy4	568	57	degeneration	degeneration	NN
cord-259748-x7dq1sy4	568	58	Multiple	multiple	JJ
cord-259748-x7dq1sy4	568	59	sclerosis	sclerosis	NN
cord-259748-x7dq1sy4	568	60	Type	type	NN
cord-259748-x7dq1sy4	568	61	I	I	NNP
cord-259748-x7dq1sy4	568	62	/	/	SYM
cord-259748-x7dq1sy4	568	63	II	II	NNP
cord-259748-x7dq1sy4	569	1	interferon	interferon	NN
cord-259748-x7dq1sy4	569	2	balance	balance	NN
cord-259748-x7dq1sy4	569	3	in	in	IN
cord-259748-x7dq1sy4	569	4	the	the	DT
cord-259748-x7dq1sy4	569	5	regulation	regulation	NN
cord-259748-x7dq1sy4	569	6	of	of	IN
cord-259748-x7dq1sy4	569	7	brain	brain	NN
cord-259748-x7dq1sy4	569	8	physiology	physiology	NN
cord-259748-x7dq1sy4	569	9	and	and	CC
cord-259748-x7dq1sy4	569	10	pathology	pathology	NN
cord-259748-x7dq1sy4	569	11	Activation	activation	NN
cord-259748-x7dq1sy4	569	12	of	of	IN
cord-259748-x7dq1sy4	569	13	the	the	DT
cord-259748-x7dq1sy4	569	14	STING	sting	NN
cord-259748-x7dq1sy4	569	15	-	-	HYPH
cord-259748-x7dq1sy4	569	16	dependent	dependent	JJ
cord-259748-x7dq1sy4	569	17	Type	type	NN
cord-259748-x7dq1sy4	570	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	571	1	interferon	interferon	NNP
cord-259748-x7dq1sy4	571	2	response	response	NN
cord-259748-x7dq1sy4	571	3	reduces	reduce	VBZ
cord-259748-x7dq1sy4	571	4	microglial	microglial	JJ
cord-259748-x7dq1sy4	571	5	reactivity	reactivity	NN
cord-259748-x7dq1sy4	571	6	and	and	CC
cord-259748-x7dq1sy4	571	7	neuroinflammation	neuroinflammation	NN
cord-259748-x7dq1sy4	571	8	Modulation	modulation	NN
cord-259748-x7dq1sy4	571	9	of	of	IN
cord-259748-x7dq1sy4	571	10	the	the	DT
cord-259748-x7dq1sy4	571	11	immune	immune	JJ
cord-259748-x7dq1sy4	571	12	system	system	NN
cord-259748-x7dq1sy4	571	13	by	by	IN
cord-259748-x7dq1sy4	571	14	UV	uv	NN
cord-259748-x7dq1sy4	571	15	radiation	radiation	NN
cord-259748-x7dq1sy4	571	16	:	:	:
cord-259748-x7dq1sy4	571	17	more	more	JJR
cord-259748-x7dq1sy4	571	18	than	than	IN
cord-259748-x7dq1sy4	571	19	just	just	RB
cord-259748-x7dq1sy4	571	20	the	the	DT
cord-259748-x7dq1sy4	571	21	effects	effect	NNS
cord-259748-x7dq1sy4	571	22	of	of	IN
cord-259748-x7dq1sy4	571	23	vitamin	vitamin	NN
cord-259748-x7dq1sy4	571	24	D	d	NN
cord-259748-x7dq1sy4	571	25	?	?	.
cord-259748-x7dq1sy4	572	1	Ultraviolet	ultraviolet	NN
cord-259748-x7dq1sy4	572	2	b	b	NN
cord-259748-x7dq1sy4	572	3	irradiation	irradiation	NN
cord-259748-x7dq1sy4	572	4	causes	cause	VBZ
cord-259748-x7dq1sy4	572	5	stimulator	stimulator	NN
cord-259748-x7dq1sy4	572	6	of	of	IN
cord-259748-x7dq1sy4	572	7	interferon	interferon	NN
cord-259748-x7dq1sy4	572	8	genes	gene	NNS
cord-259748-x7dq1sy4	572	9	-	-	HYPH
cord-259748-x7dq1sy4	572	10	dependent	dependent	JJ
cord-259748-x7dq1sy4	572	11	production	production	NN
cord-259748-x7dq1sy4	572	12	of	of	IN
cord-259748-x7dq1sy4	572	13	protective	protective	JJ
cord-259748-x7dq1sy4	572	14	Type	type	NN
cord-259748-x7dq1sy4	572	15	I	-PRON-	PRP
cord-259748-x7dq1sy4	572	16	interferon	interferon	VBD
cord-259748-x7dq1sy4	572	17	in	in	IN
cord-259748-x7dq1sy4	572	18	mouse	mouse	NN
cord-259748-x7dq1sy4	572	19	skin	skin	NN
cord-259748-x7dq1sy4	572	20	by	by	IN
cord-259748-x7dq1sy4	572	21	recruited	recruit	VBN
cord-259748-x7dq1sy4	572	22	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	572	23	monocytes	monocyte	NNS
cord-259748-x7dq1sy4	572	24	.	.	.
cord-259748-x7dq1sy4	573	1	Arthritis	Arthritis	NNP
cord-259748-x7dq1sy4	573	2	Rheumatol	Rheumatol	NNP
cord-259748-x7dq1sy4	573	3	Engineering	Engineering	NNP
cord-259748-x7dq1sy4	573	4	DNA	DNA	NNP
cord-259748-x7dq1sy4	573	5	nanoparticles	nanoparticle	NNS
cord-259748-x7dq1sy4	573	6	as	as	IN
cord-259748-x7dq1sy4	573	7	immunomodulatory	immunomodulatory	JJ
cord-259748-x7dq1sy4	573	8	reagents	reagent	NNS
cord-259748-x7dq1sy4	573	9	that	that	WDT
cord-259748-x7dq1sy4	573	10	activate	activate	VBP
cord-259748-x7dq1sy4	573	11	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	573	12	T	t	NN
cord-259748-x7dq1sy4	573	13	cells	cell	NNS
cord-259748-x7dq1sy4	573	14	Activation	activation	NN
cord-259748-x7dq1sy4	573	15	of	of	IN
cord-259748-x7dq1sy4	573	16	the	the	DT
cord-259748-x7dq1sy4	573	17	STING	sting	NN
cord-259748-x7dq1sy4	573	18	adaptor	adaptor	NN
cord-259748-x7dq1sy4	573	19	attenuates	attenuate	VBZ
cord-259748-x7dq1sy4	573	20	experimental	experimental	JJ
cord-259748-x7dq1sy4	573	21	autoimmune	autoimmune	NN
cord-259748-x7dq1sy4	573	22	encephalitis	encephalitis	RB
cord-259748-x7dq1sy4	574	1	Nucleic	nucleic	JJ
cord-259748-x7dq1sy4	574	2	acid	acid	NN
cord-259748-x7dq1sy4	574	3	sensing	sensing	NN
cord-259748-x7dq1sy4	574	4	by	by	IN
cord-259748-x7dq1sy4	574	5	T	T	NNP
cord-259748-x7dq1sy4	574	6	cells	cell	NNS
cord-259748-x7dq1sy4	574	7	initiates	initiate	VBZ
cord-259748-x7dq1sy4	574	8	Th2	Th2	NNP
cord-259748-x7dq1sy4	574	9	cell	cell	NN
cord-259748-x7dq1sy4	574	10	differentiation	differentiation	NN
cord-259748-x7dq1sy4	574	11	STING	sting	NN
cord-259748-x7dq1sy4	574	12	-	-	HYPH
cord-259748-x7dq1sy4	574	13	associated	associate	VBN
cord-259748-x7dq1sy4	574	14	lung	lung	NN
cord-259748-x7dq1sy4	574	15	disease	disease	NN
cord-259748-x7dq1sy4	574	16	in	in	IN
cord-259748-x7dq1sy4	574	17	mice	mice	NN
cord-259748-x7dq1sy4	574	18	relies	rely	VBZ
cord-259748-x7dq1sy4	574	19	on	on	IN
cord-259748-x7dq1sy4	574	20	T	t	NN
cord-259748-x7dq1sy4	574	21	cells	cell	NNS
cord-259748-x7dq1sy4	574	22	but	but	CC
cord-259748-x7dq1sy4	574	23	not	not	RB
cord-259748-x7dq1sy4	574	24	type	type	NN
cord-259748-x7dq1sy4	574	25	I	-PRON-	PRP
cord-259748-x7dq1sy4	574	26	interferon	interferon	VBD
cord-259748-x7dq1sy4	574	27	Hierarchy	Hierarchy	NNP
cord-259748-x7dq1sy4	574	28	of	of	IN
cord-259748-x7dq1sy4	574	29	clinical	clinical	JJ
cord-259748-x7dq1sy4	574	30	manifestations	manifestation	NNS
cord-259748-x7dq1sy4	574	31	in	in	IN
cord-259748-x7dq1sy4	574	32	SAVI	SAVI	NNP
cord-259748-x7dq1sy4	574	33	N153S	N153S	NNP
cord-259748-x7dq1sy4	574	34	and	and	CC
cord-259748-x7dq1sy4	574	35	V154	V154	NNP
cord-259748-x7dq1sy4	574	36	M	M	NNP
cord-259748-x7dq1sy4	574	37	mouse	mouse	NN
cord-259748-x7dq1sy4	574	38	models	model	NNS
cord-259748-x7dq1sy4	575	1	Intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	575	2	antiproliferative	antiproliferative	JJ
cord-259748-x7dq1sy4	575	3	activity	activity	NN
cord-259748-x7dq1sy4	575	4	of	of	IN
cord-259748-x7dq1sy4	575	5	the	the	DT
cord-259748-x7dq1sy4	575	6	innate	innate	JJ
cord-259748-x7dq1sy4	575	7	sensor	sensor	NN
cord-259748-x7dq1sy4	575	8	STING	sting	NN
cord-259748-x7dq1sy4	575	9	in	in	IN
cord-259748-x7dq1sy4	575	10	T	t	NN
cord-259748-x7dq1sy4	575	11	lymphocytes	lymphocyte	NNS
cord-259748-x7dq1sy4	575	12	Agonist	agonist	NN
cord-259748-x7dq1sy4	575	13	-	-	HYPH
cord-259748-x7dq1sy4	575	14	Mediated	mediate	VBN
cord-259748-x7dq1sy4	575	15	activation	activation	NN
cord-259748-x7dq1sy4	575	16	of	of	IN
cord-259748-x7dq1sy4	575	17	STING	sting	NN
cord-259748-x7dq1sy4	575	18	induces	induce	VBZ
cord-259748-x7dq1sy4	575	19	apoptosis	apoptosis	NN
cord-259748-x7dq1sy4	575	20	in	in	IN
cord-259748-x7dq1sy4	575	21	malignant	malignant	JJ
cord-259748-x7dq1sy4	575	22	B	b	NN
cord-259748-x7dq1sy4	575	23	Cells	cell	NNS
cord-259748-x7dq1sy4	575	24	B	B	NNP
cord-259748-x7dq1sy4	575	25	cell	cell	NN
cord-259748-x7dq1sy4	575	26	-	-	:
cord-259748-x7dq1sy4	575	27	Intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	575	28	STING	sting	NN
cord-259748-x7dq1sy4	575	29	signaling	signal	VBG
cord-259748-x7dq1sy4	575	30	triggers	trigger	NNS
cord-259748-x7dq1sy4	575	31	cell	cell	NN
cord-259748-x7dq1sy4	575	32	activation	activation	NN
cord-259748-x7dq1sy4	575	33	,	,	,
cord-259748-x7dq1sy4	575	34	synergizes	synergize	VBZ
cord-259748-x7dq1sy4	575	35	with	with	IN
cord-259748-x7dq1sy4	575	36	B	b	NN
cord-259748-x7dq1sy4	575	37	cell	cell	NN
cord-259748-x7dq1sy4	575	38	receptor	receptor	NN
cord-259748-x7dq1sy4	575	39	signals	signal	NNS
cord-259748-x7dq1sy4	575	40	,	,	,
cord-259748-x7dq1sy4	575	41	and	and	CC
cord-259748-x7dq1sy4	575	42	promotes	promote	VBZ
cord-259748-x7dq1sy4	575	43	antibody	antibody	NN
cord-259748-x7dq1sy4	575	44	responses	response	NNS
cord-259748-x7dq1sy4	575	45	STING	sting	VB
cord-259748-x7dq1sy4	575	46	signaling	signal	VBG
cord-259748-x7dq1sy4	575	47	promotes	promote	VBZ
cord-259748-x7dq1sy4	575	48	inflammation	inflammation	NN
cord-259748-x7dq1sy4	575	49	in	in	IN
cord-259748-x7dq1sy4	575	50	experimental	experimental	JJ
cord-259748-x7dq1sy4	575	51	acute	acute	JJ
cord-259748-x7dq1sy4	575	52	pancreatitis	pancreatitis	NN
cord-259748-x7dq1sy4	575	53	Habtezion	Habtezion	NNP
cord-259748-x7dq1sy4	575	54	A.	a.	NN
cord-259748-x7dq1sy4	575	55	STING	sting	NN
cord-259748-x7dq1sy4	575	56	signalling	signal	VBG
cord-259748-x7dq1sy4	575	57	protects	protect	VBZ
cord-259748-x7dq1sy4	575	58	against	against	IN
cord-259748-x7dq1sy4	575	59	chronic	chronic	JJ
cord-259748-x7dq1sy4	575	60	pancreatitis	pancreatitis	NN
cord-259748-x7dq1sy4	575	61	by	by	IN
cord-259748-x7dq1sy4	575	62	modulating	modulate	VBG
cord-259748-x7dq1sy4	575	63	Th17	Th17	NNP
cord-259748-x7dq1sy4	576	1	response	response	NN
cord-259748-x7dq1sy4	576	2	STINGactivating	stingactivate	VBG
cord-259748-x7dq1sy4	576	3	adjuvants	adjuvant	NNS
cord-259748-x7dq1sy4	576	4	elicit	elicit	VBP
cord-259748-x7dq1sy4	576	5	a	a	DT
cord-259748-x7dq1sy4	576	6	Th17	th17	CD
cord-259748-x7dq1sy4	576	7	immune	immune	JJ
cord-259748-x7dq1sy4	576	8	response	response	NN
cord-259748-x7dq1sy4	576	9	and	and	CC
cord-259748-x7dq1sy4	576	10	protect	protect	VB
cord-259748-x7dq1sy4	576	11	against	against	IN
cord-259748-x7dq1sy4	576	12	Mycobacterium	Mycobacterium	NNP
cord-259748-x7dq1sy4	576	13	tuberculosis	tuberculosis	NN
cord-259748-x7dq1sy4	576	14	infection	infection	NN
cord-259748-x7dq1sy4	576	15	STING	sting	NN
cord-259748-x7dq1sy4	576	16	-	-	HYPH
cord-259748-x7dq1sy4	576	17	dependent	dependent	JJ
cord-259748-x7dq1sy4	576	18	signaling	signaling	NN
cord-259748-x7dq1sy4	576	19	underlies	underlie	VBZ
cord-259748-x7dq1sy4	576	20	IL-10	IL-10	NNP
cord-259748-x7dq1sy4	576	21	controlled	control	VBD
cord-259748-x7dq1sy4	576	22	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	576	23	colitis	colitis	NN
cord-259748-x7dq1sy4	576	24	The	the	DT
cord-259748-x7dq1sy4	576	25	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	576	26	sensor	sensor	NN
cord-259748-x7dq1sy4	576	27	STING	sting	NN
cord-259748-x7dq1sy4	576	28	is	be	VBZ
cord-259748-x7dq1sy4	576	29	required	require	VBN
cord-259748-x7dq1sy4	576	30	for	for	IN
cord-259748-x7dq1sy4	576	31	intestinal	intestinal	JJ
cord-259748-x7dq1sy4	576	32	homeostasis	homeostasis	NN
cord-259748-x7dq1sy4	576	33	and	and	CC
cord-259748-x7dq1sy4	576	34	control	control	NN
cord-259748-x7dq1sy4	576	35	of	of	IN
cord-259748-x7dq1sy4	576	36	inflammation	inflammation	NN
cord-259748-x7dq1sy4	577	1	The	the	DT
cord-259748-x7dq1sy4	577	2	multifaceted	multifaceted	JJ
cord-259748-x7dq1sy4	577	3	role	role	NN
cord-259748-x7dq1sy4	577	4	of	of	IN
cord-259748-x7dq1sy4	577	5	chromosomal	chromosomal	JJ
cord-259748-x7dq1sy4	577	6	instability	instability	NN
cord-259748-x7dq1sy4	577	7	in	in	IN
cord-259748-x7dq1sy4	577	8	cancer	cancer	NN
cord-259748-x7dq1sy4	577	9	and	and	CC
cord-259748-x7dq1sy4	577	10	its	-PRON-	PRP$
cord-259748-x7dq1sy4	577	11	microenvironment	microenvironment	NN
cord-259748-x7dq1sy4	577	12	Immunogenic	immunogenic	JJ
cord-259748-x7dq1sy4	577	13	cell	cell	NN
cord-259748-x7dq1sy4	577	14	death	death	NN
cord-259748-x7dq1sy4	577	15	in	in	IN
cord-259748-x7dq1sy4	577	16	cancer	cancer	NN
cord-259748-x7dq1sy4	577	17	and	and	CC
cord-259748-x7dq1sy4	577	18	infectious	infectious	JJ
cord-259748-x7dq1sy4	577	19	disease	disease	NN
cord-259748-x7dq1sy4	577	20	STING	sting	NN
cord-259748-x7dq1sy4	577	21	contributes	contribute	VBZ
cord-259748-x7dq1sy4	577	22	to	to	TO
cord-259748-x7dq1sy4	577	23	antiglioma	antiglioma	VB
cord-259748-x7dq1sy4	577	24	immunity	immunity	NN
cord-259748-x7dq1sy4	577	25	via	via	IN
cord-259748-x7dq1sy4	577	26	triggering	trigger	VBG
cord-259748-x7dq1sy4	577	27	type	type	NN
cord-259748-x7dq1sy4	578	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	578	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	578	3	signals	signal	VBZ
cord-259748-x7dq1sy4	578	4	in	in	IN
cord-259748-x7dq1sy4	578	5	the	the	DT
cord-259748-x7dq1sy4	578	6	tumor	tumor	NN
cord-259748-x7dq1sy4	578	7	microenvironment	microenvironment	NN
cord-259748-x7dq1sy4	578	8	STING	sting	NN
cord-259748-x7dq1sy4	578	9	-	-	HYPH
cord-259748-x7dq1sy4	578	10	dependent	dependent	JJ
cord-259748-x7dq1sy4	578	11	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	578	12	DNA	dna	NN
cord-259748-x7dq1sy4	578	13	sensing	sensing	NN
cord-259748-x7dq1sy4	578	14	mediates	mediate	VBZ
cord-259748-x7dq1sy4	578	15	innate	innate	JJ
cord-259748-x7dq1sy4	578	16	immune	immune	JJ
cord-259748-x7dq1sy4	578	17	recognition	recognition	NN
cord-259748-x7dq1sy4	578	18	of	of	IN
cord-259748-x7dq1sy4	578	19	immunogenic	immunogenic	JJ
cord-259748-x7dq1sy4	578	20	tumors	tumor	NNS
cord-259748-x7dq1sy4	578	21	Suppression	suppression	NN
cord-259748-x7dq1sy4	578	22	of	of	IN
cord-259748-x7dq1sy4	578	23	STING	sting	NN
cord-259748-x7dq1sy4	578	24	associated	associate	VBN
cord-259748-x7dq1sy4	578	25	with	with	IN
cord-259748-x7dq1sy4	578	26	LKB1	LKB1	NNP
cord-259748-x7dq1sy4	578	27	Loss	Loss	NNP
cord-259748-x7dq1sy4	578	28	in	in	IN
cord-259748-x7dq1sy4	578	29	KRAS	KRAS	NNP
cord-259748-x7dq1sy4	578	30	-	-	HYPH
cord-259748-x7dq1sy4	578	31	driven	drive	VBN
cord-259748-x7dq1sy4	578	32	lung	lung	NN
cord-259748-x7dq1sy4	578	33	cancer	cancer	NN
cord-259748-x7dq1sy4	578	34	DNA	dna	NN
cord-259748-x7dq1sy4	578	35	exonuclease	exonuclease	NN
cord-259748-x7dq1sy4	579	1	Trex1	Trex1	NNP
cord-259748-x7dq1sy4	579	2	regulates	regulate	VBZ
cord-259748-x7dq1sy4	580	1	radiotherapy	radiotherapy	NN
cord-259748-x7dq1sy4	580	2	-	-	HYPH
cord-259748-x7dq1sy4	580	3	induced	induce	VBN
cord-259748-x7dq1sy4	580	4	tumour	tumour	NN
cord-259748-x7dq1sy4	580	5	immunogenicity	immunogenicity	NN
cord-259748-x7dq1sy4	580	6	Growing	grow	VBG
cord-259748-x7dq1sy4	580	7	tumors	tumor	NNS
cord-259748-x7dq1sy4	580	8	induce	induce	VBP
cord-259748-x7dq1sy4	580	9	a	a	DT
cord-259748-x7dq1sy4	580	10	local	local	JJ
cord-259748-x7dq1sy4	580	11	STING	sting	NN
cord-259748-x7dq1sy4	580	12	dependent	dependent	JJ
cord-259748-x7dq1sy4	580	13	Type	type	NN
cord-259748-x7dq1sy4	580	14	I	-PRON-	PRP
cord-259748-x7dq1sy4	580	15	IFN	IFN	NNP
cord-259748-x7dq1sy4	580	16	response	response	NN
cord-259748-x7dq1sy4	580	17	in	in	IN
cord-259748-x7dq1sy4	580	18	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	580	19	cells	cell	NNS
cord-259748-x7dq1sy4	581	1	Tumorderived	Tumorderived	NNP
cord-259748-x7dq1sy4	581	2	cGAMP	cGAMP	NNS
cord-259748-x7dq1sy4	581	3	triggers	trigger	VBZ
cord-259748-x7dq1sy4	581	4	a	a	DT
cord-259748-x7dq1sy4	581	5	STING	sting	NN
cord-259748-x7dq1sy4	581	6	-	-	HYPH
cord-259748-x7dq1sy4	581	7	mediated	mediate	VBN
cord-259748-x7dq1sy4	581	8	interferon	interferon	NN
cord-259748-x7dq1sy4	581	9	response	response	NN
cord-259748-x7dq1sy4	581	10	in	in	IN
cord-259748-x7dq1sy4	581	11	nontumor	nontumor	NN
cord-259748-x7dq1sy4	581	12	cells	cell	NNS
cord-259748-x7dq1sy4	581	13	to	to	TO
cord-259748-x7dq1sy4	581	14	activate	activate	VB
cord-259748-x7dq1sy4	581	15	the	the	DT
cord-259748-x7dq1sy4	581	16	NK	NK	NNP
cord-259748-x7dq1sy4	581	17	cell	cell	NN
cord-259748-x7dq1sy4	581	18	response	response	NN
cord-259748-x7dq1sy4	581	19	RAE1	RAE1	NNP
cord-259748-x7dq1sy4	581	20	ligands	ligand	NNS
cord-259748-x7dq1sy4	581	21	for	for	IN
cord-259748-x7dq1sy4	581	22	the	the	DT
cord-259748-x7dq1sy4	581	23	NKG2D	NKG2D	NNP
cord-259748-x7dq1sy4	581	24	receptor	receptor	NN
cord-259748-x7dq1sy4	581	25	are	be	VBP
cord-259748-x7dq1sy4	581	26	regulated	regulate	VBN
cord-259748-x7dq1sy4	581	27	by	by	IN
cord-259748-x7dq1sy4	581	28	STING	sting	NN
cord-259748-x7dq1sy4	581	29	-	-	HYPH
cord-259748-x7dq1sy4	581	30	dependent	dependent	JJ
cord-259748-x7dq1sy4	581	31	DNA	dna	NN
cord-259748-x7dq1sy4	581	32	sensor	sensor	NN
cord-259748-x7dq1sy4	581	33	pathways	pathway	NNS
cord-259748-x7dq1sy4	581	34	in	in	IN
cord-259748-x7dq1sy4	581	35	lymphoma	lymphoma	NN
cord-259748-x7dq1sy4	581	36	STING	STING	NNP
cord-259748-x7dq1sy4	581	37	activation	activation	NN
cord-259748-x7dq1sy4	582	1	reprograms	reprograms	NNP
cord-259748-x7dq1sy4	582	2	tumor	tumor	NN
cord-259748-x7dq1sy4	582	3	vasculatures	vasculature	NNS
cord-259748-x7dq1sy4	582	4	and	and	CC
cord-259748-x7dq1sy4	582	5	synergizes	synergize	VBZ
cord-259748-x7dq1sy4	582	6	with	with	IN
cord-259748-x7dq1sy4	582	7	VEGFR2	vegfr2	NN
cord-259748-x7dq1sy4	582	8	blockade	blockade	NN
cord-259748-x7dq1sy4	582	9	Dendritic	dendritic	JJ
cord-259748-x7dq1sy4	582	10	cells	cell	NNS
cord-259748-x7dq1sy4	582	11	but	but	CC
cord-259748-x7dq1sy4	582	12	not	not	RB
cord-259748-x7dq1sy4	582	13	macrophages	macrophage	VBZ
cord-259748-x7dq1sy4	582	14	sense	sense	NN
cord-259748-x7dq1sy4	582	15	tumor	tumor	NN
cord-259748-x7dq1sy4	582	16	mitochondrial	mitochondrial	NN
cord-259748-x7dq1sy4	582	17	DNA	dna	NN
cord-259748-x7dq1sy4	582	18	for	for	IN
cord-259748-x7dq1sy4	582	19	cross	cross	NN
cord-259748-x7dq1sy4	582	20	-	-	JJ
cord-259748-x7dq1sy4	582	21	priming	prime	VBG
cord-259748-x7dq1sy4	582	22	through	through	IN
cord-259748-x7dq1sy4	582	23	signal	signal	JJ
cord-259748-x7dq1sy4	582	24	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	582	25	protein	protein	NN
cord-259748-x7dq1sy4	582	26	alpha	alpha	NN
cord-259748-x7dq1sy4	582	27	signaling	signal	VBG
cord-259748-x7dq1sy4	582	28	Exosomes	Exosomes	NNP
cord-259748-x7dq1sy4	582	29	shuttle	shuttle	NN
cord-259748-x7dq1sy4	582	30	TREX1-sensitive	TREX1-sensitive	NNP
cord-259748-x7dq1sy4	582	31	IFN	IFN	NNP
cord-259748-x7dq1sy4	582	32	-	-	HYPH
cord-259748-x7dq1sy4	582	33	stimulatory	stimulatory	JJ
cord-259748-x7dq1sy4	582	34	dsDNA	dsdna	RB
cord-259748-x7dq1sy4	582	35	from	from	IN
cord-259748-x7dq1sy4	582	36	irradiated	irradiate	VBN
cord-259748-x7dq1sy4	582	37	cancer	cancer	NN
cord-259748-x7dq1sy4	582	38	cells	cell	NNS
cord-259748-x7dq1sy4	582	39	to	to	IN
cord-259748-x7dq1sy4	582	40	DCs	DCs	NNP
cord-259748-x7dq1sy4	582	41	Host	Host	NNP
cord-259748-x7dq1sy4	582	42	type	type	NN
cord-259748-x7dq1sy4	583	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	583	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	583	3	signals	signal	NNS
cord-259748-x7dq1sy4	583	4	are	be	VBP
cord-259748-x7dq1sy4	583	5	required	require	VBN
cord-259748-x7dq1sy4	583	6	for	for	IN
cord-259748-x7dq1sy4	583	7	antitumor	antitumor	JJ
cord-259748-x7dq1sy4	583	8	CD8	CD8	NNP
cord-259748-x7dq1sy4	583	9	+	+	CC
cord-259748-x7dq1sy4	583	10	T	T	NNP
cord-259748-x7dq1sy4	583	11	cell	cell	NN
cord-259748-x7dq1sy4	583	12	responses	response	NNS
cord-259748-x7dq1sy4	583	13	through	through	IN
cord-259748-x7dq1sy4	583	14	CD8{alpha}+	CD8{alpha}+	NNP
cord-259748-x7dq1sy4	583	15	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	583	16	cells	cell	NNS
cord-259748-x7dq1sy4	584	1	STING	sting	NN
cord-259748-x7dq1sy4	584	2	-	-	HYPH
cord-259748-x7dq1sy4	584	3	dependent	dependent	JJ
cord-259748-x7dq1sy4	584	4	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	584	5	DNA	dna	NN
cord-259748-x7dq1sy4	584	6	sensing	sensing	NN
cord-259748-x7dq1sy4	584	7	promotes	promote	VBZ
cord-259748-x7dq1sy4	584	8	radiation	radiation	NN
cord-259748-x7dq1sy4	584	9	-	-	HYPH
cord-259748-x7dq1sy4	584	10	induced	induce	VBN
cord-259748-x7dq1sy4	584	11	Type	type	NN
cord-259748-x7dq1sy4	585	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	585	2	interferondependent	interferondependent	VBP
cord-259748-x7dq1sy4	585	3	antitumor	antitumor	JJ
cord-259748-x7dq1sy4	585	4	immunity	immunity	NN
cord-259748-x7dq1sy4	585	5	in	in	IN
cord-259748-x7dq1sy4	585	6	immunogenic	immunogenic	JJ
cord-259748-x7dq1sy4	585	7	tumors	tumor	NNS
cord-259748-x7dq1sy4	586	1	Targeting	target	VBG
cord-259748-x7dq1sy4	586	2	DNA	dna	NN
cord-259748-x7dq1sy4	586	3	damage	damage	NN
cord-259748-x7dq1sy4	586	4	response	response	NN
cord-259748-x7dq1sy4	586	5	promotes	promote	VBZ
cord-259748-x7dq1sy4	586	6	antitumor	antitumor	JJ
cord-259748-x7dq1sy4	586	7	immunity	immunity	NN
cord-259748-x7dq1sy4	586	8	through	through	IN
cord-259748-x7dq1sy4	586	9	STING	sting	NN
cord-259748-x7dq1sy4	586	10	-	-	HYPH
cord-259748-x7dq1sy4	586	11	mediated	mediate	VBN
cord-259748-x7dq1sy4	586	12	T	t	NN
cord-259748-x7dq1sy4	586	13	-	-	HYPH
cord-259748-x7dq1sy4	586	14	cell	cell	NN
cord-259748-x7dq1sy4	586	15	activation	activation	NN
cord-259748-x7dq1sy4	586	16	in	in	IN
cord-259748-x7dq1sy4	586	17	small	small	JJ
cord-259748-x7dq1sy4	586	18	cell	cell	NN
cord-259748-x7dq1sy4	586	19	lung	lung	NN
cord-259748-x7dq1sy4	586	20	cancer	cancer	NN
cord-259748-x7dq1sy4	586	21	Intratumoral	Intratumoral	NNP
cord-259748-x7dq1sy4	586	22	STING	STING	NNP
cord-259748-x7dq1sy4	586	23	activation	activation	NN
cord-259748-x7dq1sy4	586	24	with	with	IN
cord-259748-x7dq1sy4	586	25	T	t	NN
cord-259748-x7dq1sy4	586	26	-	-	HYPH
cord-259748-x7dq1sy4	586	27	cell	cell	NN
cord-259748-x7dq1sy4	586	28	checkpoint	checkpoint	NN
cord-259748-x7dq1sy4	586	29	modulation	modulation	NN
cord-259748-x7dq1sy4	586	30	generates	generate	VBZ
cord-259748-x7dq1sy4	586	31	systemic	systemic	JJ
cord-259748-x7dq1sy4	586	32	antitumor	antitumor	JJ
cord-259748-x7dq1sy4	586	33	immunity	immunity	NN
cord-259748-x7dq1sy4	586	34	STING	sting	NN
cord-259748-x7dq1sy4	586	35	signaling	signal	VBG
cord-259748-x7dq1sy4	586	36	remodels	remodel	NNS
cord-259748-x7dq1sy4	586	37	the	the	DT
cord-259748-x7dq1sy4	586	38	tumor	tumor	NN
cord-259748-x7dq1sy4	586	39	microenvironment	microenvironment	NN
cord-259748-x7dq1sy4	586	40	by	by	IN
cord-259748-x7dq1sy4	586	41	antagonizing	antagonize	VBG
cord-259748-x7dq1sy4	586	42	myeloid	myeloid	NN
cord-259748-x7dq1sy4	586	43	-	-	HYPH
cord-259748-x7dq1sy4	586	44	derived	derive	VBN
cord-259748-x7dq1sy4	586	45	suppressor	suppressor	NN
cord-259748-x7dq1sy4	586	46	cell	cell	NN
cord-259748-x7dq1sy4	586	47	expansion	expansion	NN
cord-259748-x7dq1sy4	587	1	IL-15	IL-15	NNP
cord-259748-x7dq1sy4	587	2	is	be	VBZ
cord-259748-x7dq1sy4	587	3	a	a	DT
cord-259748-x7dq1sy4	587	4	component	component	NN
cord-259748-x7dq1sy4	587	5	of	of	IN
cord-259748-x7dq1sy4	587	6	the	the	DT
cord-259748-x7dq1sy4	587	7	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	587	8	milieu	milieu	NN
cord-259748-x7dq1sy4	587	9	in	in	IN
cord-259748-x7dq1sy4	587	10	the	the	DT
cord-259748-x7dq1sy4	587	11	tumor	tumor	NN
cord-259748-x7dq1sy4	587	12	microenvironment	microenvironment	NN
cord-259748-x7dq1sy4	587	13	promoting	promote	VBG
cord-259748-x7dq1sy4	587	14	antitumor	antitumor	JJ
cord-259748-x7dq1sy4	587	15	responses	response	NNS
cord-259748-x7dq1sy4	587	16	Suppression	Suppression	NNP
cord-259748-x7dq1sy4	587	17	of	of	IN
cord-259748-x7dq1sy4	587	18	STING	sting	NN
cord-259748-x7dq1sy4	587	19	signaling	signal	VBG
cord-259748-x7dq1sy4	587	20	through	through	IN
cord-259748-x7dq1sy4	587	21	epigenetic	epigenetic	JJ
cord-259748-x7dq1sy4	587	22	silencing	silencing	NN
cord-259748-x7dq1sy4	587	23	and	and	CC
cord-259748-x7dq1sy4	587	24	missense	missense	NN
cord-259748-x7dq1sy4	587	25	mutation	mutation	NN
cord-259748-x7dq1sy4	587	26	impedes	impede	VBZ
cord-259748-x7dq1sy4	588	1	DNA	dna	NN
cord-259748-x7dq1sy4	588	2	damage	damage	NN
cord-259748-x7dq1sy4	588	3	mediated	mediate	VBN
cord-259748-x7dq1sy4	588	4	cytokine	cytokine	NN
cord-259748-x7dq1sy4	588	5	production	production	NN
cord-259748-x7dq1sy4	588	6	Extrachromosomal	Extrachromosomal	NNP
cord-259748-x7dq1sy4	588	7	telomere	telomere	NN
cord-259748-x7dq1sy4	588	8	repeat	repeat	NN
cord-259748-x7dq1sy4	588	9	DNA	DNA	NNP
cord-259748-x7dq1sy4	588	10	is	be	VBZ
cord-259748-x7dq1sy4	588	11	linked	link	VBN
cord-259748-x7dq1sy4	588	12	to	to	IN
cord-259748-x7dq1sy4	588	13	ALT	alt	NN
cord-259748-x7dq1sy4	588	14	development	development	NN
cord-259748-x7dq1sy4	588	15	via	via	IN
cord-259748-x7dq1sy4	588	16	cGAS	cgas	JJ
cord-259748-x7dq1sy4	588	17	-	-	HYPH
cord-259748-x7dq1sy4	588	18	STING	sting	NN
cord-259748-x7dq1sy4	588	19	DNA	dna	NN
cord-259748-x7dq1sy4	588	20	sensing	sensing	NN
cord-259748-x7dq1sy4	588	21	pathway	pathway	NN
cord-259748-x7dq1sy4	588	22	Downregulation	Downregulation	NNP
cord-259748-x7dq1sy4	588	23	of	of	IN
cord-259748-x7dq1sy4	588	24	membrane	membrane	NN
cord-259748-x7dq1sy4	588	25	trafficking	trafficking	NN
cord-259748-x7dq1sy4	588	26	proteins	protein	NNS
cord-259748-x7dq1sy4	588	27	and	and	CC
cord-259748-x7dq1sy4	588	28	lactate	lactate	NN
cord-259748-x7dq1sy4	588	29	conditioning	conditioning	NN
cord-259748-x7dq1sy4	588	30	determine	determine	VBP
cord-259748-x7dq1sy4	588	31	loss	loss	NN
cord-259748-x7dq1sy4	588	32	of	of	IN
cord-259748-x7dq1sy4	588	33	dendritic	dendritic	JJ
cord-259748-x7dq1sy4	588	34	cell	cell	NN
cord-259748-x7dq1sy4	588	35	function	function	NN
cord-259748-x7dq1sy4	588	36	in	in	IN
cord-259748-x7dq1sy4	588	37	lung	lung	NN
cord-259748-x7dq1sy4	588	38	cancer	cancer	NN
cord-259748-x7dq1sy4	588	39	HER2	HER2	NNP
cord-259748-x7dq1sy4	588	40	recruits	recruit	VBZ
cord-259748-x7dq1sy4	588	41	AKT1	AKT1	NNP
cord-259748-x7dq1sy4	588	42	to	to	TO
cord-259748-x7dq1sy4	588	43	disrupt	disrupt	VB
cord-259748-x7dq1sy4	588	44	STING	sting	NN
cord-259748-x7dq1sy4	588	45	signalling	signal	VBG
cord-259748-x7dq1sy4	588	46	and	and	CC
cord-259748-x7dq1sy4	588	47	suppress	suppress	VB
cord-259748-x7dq1sy4	588	48	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	588	49	defence	defence	NN
cord-259748-x7dq1sy4	588	50	and	and	CC
cord-259748-x7dq1sy4	588	51	antitumour	antitumour	NN
cord-259748-x7dq1sy4	588	52	immunity	immunity	NN
cord-259748-x7dq1sy4	589	1	Akt	Akt	NNP
cord-259748-x7dq1sy4	589	2	kinase	kinase	NN
cord-259748-x7dq1sy4	589	3	-	-	HYPH
cord-259748-x7dq1sy4	589	4	mediated	mediate	VBN
cord-259748-x7dq1sy4	589	5	checkpoint	checkpoint	NN
cord-259748-x7dq1sy4	589	6	of	of	IN
cord-259748-x7dq1sy4	589	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	589	8	DNA	dna	NN
cord-259748-x7dq1sy4	589	9	sensing	sensing	NN
cord-259748-x7dq1sy4	589	10	pathway	pathway	NN
cord-259748-x7dq1sy4	589	11	DNA	dna	NN
cord-259748-x7dq1sy4	589	12	damage	damage	NN
cord-259748-x7dq1sy4	589	13	predicts	predict	VBZ
cord-259748-x7dq1sy4	589	14	prognosis	prognosis	NN
cord-259748-x7dq1sy4	589	15	and	and	CC
cord-259748-x7dq1sy4	589	16	treatment	treatment	NN
cord-259748-x7dq1sy4	589	17	response	response	NN
cord-259748-x7dq1sy4	589	18	in	in	IN
cord-259748-x7dq1sy4	589	19	colorectal	colorectal	JJ
cord-259748-x7dq1sy4	589	20	liver	liver	NN
cord-259748-x7dq1sy4	589	21	metastases	metastasis	NNS
cord-259748-x7dq1sy4	589	22	superior	superior	JJ
cord-259748-x7dq1sy4	589	23	to	to	IN
cord-259748-x7dq1sy4	589	24	immunogenic	immunogenic	JJ
cord-259748-x7dq1sy4	589	25	cell	cell	NN
cord-259748-x7dq1sy4	589	26	death	death	NN
cord-259748-x7dq1sy4	589	27	and	and	CC
cord-259748-x7dq1sy4	589	28	T	t	NN
cord-259748-x7dq1sy4	589	29	cells	cell	NNS
cord-259748-x7dq1sy4	589	30	Chromosomal	chromosomal	JJ
cord-259748-x7dq1sy4	589	31	instability	instability	NN
cord-259748-x7dq1sy4	589	32	drives	drive	VBZ
cord-259748-x7dq1sy4	589	33	metastasis	metastasis	NN
cord-259748-x7dq1sy4	589	34	through	through	IN
cord-259748-x7dq1sy4	589	35	a	a	DT
cord-259748-x7dq1sy4	589	36	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	589	37	DNA	dna	NN
cord-259748-x7dq1sy4	589	38	response	response	NN
cord-259748-x7dq1sy4	590	1	Inflammation	inflammation	NN
cord-259748-x7dq1sy4	590	2	-	-	HYPH
cord-259748-x7dq1sy4	590	3	driven	drive	VBN
cord-259748-x7dq1sy4	590	4	carcinogenesis	carcinogenesis	NN
cord-259748-x7dq1sy4	590	5	is	be	VBZ
cord-259748-x7dq1sy4	590	6	mediated	mediate	VBN
cord-259748-x7dq1sy4	590	7	through	through	IN
cord-259748-x7dq1sy4	590	8	STING	sting	NN
cord-259748-x7dq1sy4	590	9	Carcinomaastrocyte	Carcinomaastrocyte	NNP
cord-259748-x7dq1sy4	590	10	gap	gap	NN
cord-259748-x7dq1sy4	590	11	junctions	junction	NNS
cord-259748-x7dq1sy4	590	12	promote	promote	VBP
cord-259748-x7dq1sy4	590	13	brain	brain	NN
cord-259748-x7dq1sy4	590	14	metastasis	metastasis	NN
cord-259748-x7dq1sy4	590	15	by	by	IN
cord-259748-x7dq1sy4	590	16	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	590	17	transfer	transfer	VB
cord-259748-x7dq1sy4	590	18	Host	Host	NNP
cord-259748-x7dq1sy4	590	19	STINGdependent	stingdependent	NN
cord-259748-x7dq1sy4	590	20	MDSC	MDSC	NNP
cord-259748-x7dq1sy4	590	21	mobilization	mobilization	NN
cord-259748-x7dq1sy4	590	22	drives	drive	VBZ
cord-259748-x7dq1sy4	590	23	extrinsic	extrinsic	JJ
cord-259748-x7dq1sy4	590	24	radiation	radiation	NN
cord-259748-x7dq1sy4	590	25	resistance	resistance	NN
cord-259748-x7dq1sy4	590	26	Tumor	Tumor	NNP
cord-259748-x7dq1sy4	590	27	cellderived	cellderived	NNP
cord-259748-x7dq1sy4	590	28	microparticles	microparticle	NNS
cord-259748-x7dq1sy4	590	29	polarize	polarize	VBP
cord-259748-x7dq1sy4	590	30	M2	M2	NNP
cord-259748-x7dq1sy4	590	31	tumor	tumor	NN
cord-259748-x7dq1sy4	590	32	-	-	HYPH
cord-259748-x7dq1sy4	590	33	associated	associate	VBN
cord-259748-x7dq1sy4	590	34	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	590	35	for	for	IN
cord-259748-x7dq1sy4	591	1	tumor	tumor	NN
cord-259748-x7dq1sy4	591	2	progression	progression	NN
cord-259748-x7dq1sy4	591	3	PARP	PARP	NNP
cord-259748-x7dq1sy4	591	4	inhibition	inhibition	NN
cord-259748-x7dq1sy4	591	5	enhances	enhance	VBZ
cord-259748-x7dq1sy4	591	6	tumor	tumor	NN
cord-259748-x7dq1sy4	591	7	cell	cell	NN
cord-259748-x7dq1sy4	591	8	-	-	HYPH
cord-259748-x7dq1sy4	591	9	intrinsic	intrinsic	JJ
cord-259748-x7dq1sy4	591	10	immunity	immunity	NN
cord-259748-x7dq1sy4	591	11	in	in	IN
cord-259748-x7dq1sy4	591	12	ERCC1-deficient	ERCC1-deficient	NNP
cord-259748-x7dq1sy4	591	13	non	non	JJ
cord-259748-x7dq1sy4	591	14	-	-	JJ
cord-259748-x7dq1sy4	591	15	small	small	JJ
cord-259748-x7dq1sy4	591	16	cell	cell	NN
cord-259748-x7dq1sy4	591	17	lung	lung	NN
cord-259748-x7dq1sy4	591	18	cancer	cancer	NN
cord-259748-x7dq1sy4	591	19	PARP	PARP	NNP
cord-259748-x7dq1sy4	591	20	inhibitor	inhibitor	NN
cord-259748-x7dq1sy4	591	21	efficacy	efficacy	NN
cord-259748-x7dq1sy4	591	22	depends	depend	VBZ
cord-259748-x7dq1sy4	591	23	on	on	IN
cord-259748-x7dq1sy4	591	24	CD8(+	CD8(+	NNP
cord-259748-x7dq1sy4	591	25	)	)	-RRB-
cord-259748-x7dq1sy4	591	26	T	t	NN
cord-259748-x7dq1sy4	591	27	-	-	HYPH
cord-259748-x7dq1sy4	591	28	cell	cell	NN
cord-259748-x7dq1sy4	591	29	recruitment	recruitment	NN
cord-259748-x7dq1sy4	591	30	via	via	IN
cord-259748-x7dq1sy4	591	31	intratumoral	intratumoral	JJ
cord-259748-x7dq1sy4	591	32	STING	STING	NNP
cord-259748-x7dq1sy4	591	33	pathway	pathway	NN
cord-259748-x7dq1sy4	591	34	activation	activation	NN
cord-259748-x7dq1sy4	591	35	in	in	IN
cord-259748-x7dq1sy4	591	36	BRCA	BRCA	NNP
cord-259748-x7dq1sy4	591	37	-	-	HYPH
cord-259748-x7dq1sy4	591	38	deficient	deficient	JJ
cord-259748-x7dq1sy4	591	39	models	model	NNS
cord-259748-x7dq1sy4	591	40	of	of	IN
cord-259748-x7dq1sy4	591	41	triple	triple	JJ
cord-259748-x7dq1sy4	591	42	-	-	HYPH
cord-259748-x7dq1sy4	591	43	negative	negative	JJ
cord-259748-x7dq1sy4	591	44	breast	breast	NN
cord-259748-x7dq1sy4	591	45	cancer	cancer	NN
cord-259748-x7dq1sy4	591	46	Radiotherapy	Radiotherapy	NNP
cord-259748-x7dq1sy4	591	47	combined	combine	VBN
cord-259748-x7dq1sy4	591	48	with	with	IN
cord-259748-x7dq1sy4	591	49	novel	novel	JJ
cord-259748-x7dq1sy4	591	50	STING	sting	NN
cord-259748-x7dq1sy4	591	51	-	-	HYPH
cord-259748-x7dq1sy4	591	52	targeting	target	VBG
cord-259748-x7dq1sy4	591	53	Oligonucleotides	Oligonucleotides	NNP
cord-259748-x7dq1sy4	591	54	results	result	NNS
cord-259748-x7dq1sy4	591	55	in	in	IN
cord-259748-x7dq1sy4	591	56	regression	regression	NN
cord-259748-x7dq1sy4	591	57	of	of	IN
cord-259748-x7dq1sy4	591	58	established	establish	VBN
cord-259748-x7dq1sy4	591	59	tumors	tumor	NNS
cord-259748-x7dq1sy4	592	1	Topoisomerase	Topoisomerase	NNP
cord-259748-x7dq1sy4	593	1	1	1	CD
cord-259748-x7dq1sy4	593	2	inhibition	inhibition	NN
cord-259748-x7dq1sy4	593	3	promotes	promote	VBZ
cord-259748-x7dq1sy4	593	4	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	593	5	GMP	GMP	NNP
cord-259748-x7dq1sy4	593	6	-	-	HYPH
cord-259748-x7dq1sy4	593	7	AMP	AMP	NNP
cord-259748-x7dq1sy4	593	8	synthasedependent	synthasedependent	NN
cord-259748-x7dq1sy4	593	9	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	593	10	responses	response	NNS
cord-259748-x7dq1sy4	594	1	Topoisomerase	Topoisomerase	NNP
cord-259748-x7dq1sy4	594	2	II	II	NNP
cord-259748-x7dq1sy4	594	3	inhibitors	inhibitor	NNS
cord-259748-x7dq1sy4	594	4	induce	induce	VBP
cord-259748-x7dq1sy4	594	5	DNA	dna	NN
cord-259748-x7dq1sy4	594	6	damage	damage	NN
cord-259748-x7dq1sy4	594	7	-	-	HYPH
cord-259748-x7dq1sy4	594	8	dependent	dependent	JJ
cord-259748-x7dq1sy4	594	9	interferon	interferon	NN
cord-259748-x7dq1sy4	594	10	responses	response	NNS
cord-259748-x7dq1sy4	594	11	circumventing	circumvent	VBG
cord-259748-x7dq1sy4	594	12	ebola	ebola	NNP
cord-259748-x7dq1sy4	594	13	virus	virus	NN
cord-259748-x7dq1sy4	594	14	immune	immune	JJ
cord-259748-x7dq1sy4	594	15	evasion	evasion	NN
cord-259748-x7dq1sy4	594	16	cGAS	cgas	NN
cord-259748-x7dq1sy4	594	17	/	/	SYM
cord-259748-x7dq1sy4	594	18	STING	sting	NN
cord-259748-x7dq1sy4	594	19	axis	axis	NN
cord-259748-x7dq1sy4	594	20	mediates	mediate	VBZ
cord-259748-x7dq1sy4	594	21	a	a	DT
cord-259748-x7dq1sy4	594	22	topoisomerase	topoisomerase	NN
cord-259748-x7dq1sy4	594	23	II	ii	CD
cord-259748-x7dq1sy4	595	1	inhibitor	inhibitor	NN
cord-259748-x7dq1sy4	595	2	-	-	HYPH
cord-259748-x7dq1sy4	595	3	induced	induce	VBN
cord-259748-x7dq1sy4	595	4	tumor	tumor	NN
cord-259748-x7dq1sy4	595	5	immunogenicity	immunogenicity	NN
cord-259748-x7dq1sy4	596	1	CD47	CD47	NNP
cord-259748-x7dq1sy4	596	2	blockade	blockade	NN
cord-259748-x7dq1sy4	596	3	triggers	trigger	VBZ
cord-259748-x7dq1sy4	596	4	T	T	NNP
cord-259748-x7dq1sy4	596	5	cell	cell	NN
cord-259748-x7dq1sy4	596	6	-	-	HYPH
cord-259748-x7dq1sy4	596	7	mediated	mediate	VBN
cord-259748-x7dq1sy4	596	8	destruction	destruction	NN
cord-259748-x7dq1sy4	596	9	of	of	IN
cord-259748-x7dq1sy4	596	10	immunogenic	immunogenic	JJ
cord-259748-x7dq1sy4	596	11	tumors	tumor	NNS
cord-259748-x7dq1sy4	596	12	STING	sting	VBP
cord-259748-x7dq1sy4	596	13	activation	activation	NN
cord-259748-x7dq1sy4	596	14	of	of	IN
cord-259748-x7dq1sy4	596	15	tumor	tumor	NN
cord-259748-x7dq1sy4	596	16	endothelial	endothelial	JJ
cord-259748-x7dq1sy4	596	17	cells	cell	NNS
cord-259748-x7dq1sy4	596	18	initiates	initiate	VBZ
cord-259748-x7dq1sy4	596	19	spontaneous	spontaneous	JJ
cord-259748-x7dq1sy4	596	20	and	and	CC
cord-259748-x7dq1sy4	596	21	therapeutic	therapeutic	JJ
cord-259748-x7dq1sy4	596	22	antitumor	antitumor	NN
cord-259748-x7dq1sy4	596	23	immunity	immunity	NN
cord-259748-x7dq1sy4	597	1	A	a	DT
cord-259748-x7dq1sy4	597	2	STING	sting	NN
cord-259748-x7dq1sy4	597	3	agonist	agonist	NN
cord-259748-x7dq1sy4	597	4	given	give	VBN
cord-259748-x7dq1sy4	597	5	with	with	IN
cord-259748-x7dq1sy4	597	6	OX40	OX40	NNP
cord-259748-x7dq1sy4	597	7	receptor	receptor	NN
cord-259748-x7dq1sy4	597	8	and	and	CC
cord-259748-x7dq1sy4	597	9	PD	PD	NNP
cord-259748-x7dq1sy4	597	10	-	-	HYPH
cord-259748-x7dq1sy4	597	11	L1	L1	NNP
cord-259748-x7dq1sy4	597	12	modulators	modulator	NNS
cord-259748-x7dq1sy4	597	13	primes	prime	VBZ
cord-259748-x7dq1sy4	597	14	immunity	immunity	NN
cord-259748-x7dq1sy4	597	15	and	and	CC
cord-259748-x7dq1sy4	597	16	reduces	reduce	VBZ
cord-259748-x7dq1sy4	597	17	tumor	tumor	NN
cord-259748-x7dq1sy4	597	18	growth	growth	NN
cord-259748-x7dq1sy4	597	19	in	in	IN
cord-259748-x7dq1sy4	597	20	tolerized	tolerized	JJ
cord-259748-x7dq1sy4	597	21	mice	mouse	NNS
cord-259748-x7dq1sy4	597	22	Magnitude	magnitude	NN
cord-259748-x7dq1sy4	597	23	of	of	IN
cord-259748-x7dq1sy4	597	24	therapeutic	therapeutic	JJ
cord-259748-x7dq1sy4	597	25	STING	sting	NN
cord-259748-x7dq1sy4	597	26	activation	activation	NN
cord-259748-x7dq1sy4	597	27	determines	determine	VBZ
cord-259748-x7dq1sy4	597	28	CD8(+	cd8(+	CD
cord-259748-x7dq1sy4	597	29	)	)	-RRB-
cord-259748-x7dq1sy4	598	1	T	T	NNP
cord-259748-x7dq1sy4	598	2	Cellmediated	Cellmediated	NNP
cord-259748-x7dq1sy4	598	3	anti	anti	JJ
cord-259748-x7dq1sy4	598	4	-	-	JJ
cord-259748-x7dq1sy4	598	5	tumor	tumor	JJ
cord-259748-x7dq1sy4	598	6	immunity	immunity	NN
cord-259748-x7dq1sy4	599	1	Recurrent	recurrent	JJ
cord-259748-x7dq1sy4	599	2	loss	loss	NN
cord-259748-x7dq1sy4	599	3	of	of	IN
cord-259748-x7dq1sy4	599	4	STING	sting	NN
cord-259748-x7dq1sy4	599	5	signaling	signal	VBG
cord-259748-x7dq1sy4	599	6	in	in	IN
cord-259748-x7dq1sy4	599	7	melanoma	melanoma	NN
cord-259748-x7dq1sy4	599	8	correlates	correlate	VBZ
cord-259748-x7dq1sy4	599	9	with	with	IN
cord-259748-x7dq1sy4	599	10	susceptibility	susceptibility	NN
cord-259748-x7dq1sy4	599	11	to	to	IN
cord-259748-x7dq1sy4	599	12	viral	viral	JJ
cord-259748-x7dq1sy4	599	13	oncolysis	oncolysis	NN
cord-259748-x7dq1sy4	599	14	Species	species	NN
cord-259748-x7dq1sy4	599	15	-	-	HYPH
cord-259748-x7dq1sy4	599	16	specific	specific	JJ
cord-259748-x7dq1sy4	599	17	detection	detection	NN
cord-259748-x7dq1sy4	599	18	of	of	IN
cord-259748-x7dq1sy4	599	19	the	the	DT
cord-259748-x7dq1sy4	599	20	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	599	21	small	small	JJ
cord-259748-x7dq1sy4	599	22	-	-	HYPH
cord-259748-x7dq1sy4	599	23	molecule	molecule	NN
cord-259748-x7dq1sy4	599	24	compound	compound	NN
cord-259748-x7dq1sy4	599	25	CMA	CMA	NNP
cord-259748-x7dq1sy4	599	26	by	by	IN
cord-259748-x7dq1sy4	599	27	STING	STING	NNP
cord-259748-x7dq1sy4	599	28	Bindingpocket	Bindingpocket	NNP
cord-259748-x7dq1sy4	599	29	and	and	CC
cord-259748-x7dq1sy4	599	30	lid	lid	NN
cord-259748-x7dq1sy4	599	31	-	-	HYPH
cord-259748-x7dq1sy4	599	32	region	region	NN
cord-259748-x7dq1sy4	599	33	substitutions	substitution	NNS
cord-259748-x7dq1sy4	599	34	render	render	VBP
cord-259748-x7dq1sy4	599	35	human	human	JJ
cord-259748-x7dq1sy4	599	36	STING	sting	NN
cord-259748-x7dq1sy4	599	37	sensitive	sensitive	JJ
cord-259748-x7dq1sy4	599	38	to	to	IN
cord-259748-x7dq1sy4	599	39	the	the	DT
cord-259748-x7dq1sy4	599	40	species	species	NN
cord-259748-x7dq1sy4	599	41	-	-	HYPH
cord-259748-x7dq1sy4	599	42	specific	specific	JJ
cord-259748-x7dq1sy4	599	43	drug	drug	NN
cord-259748-x7dq1sy4	600	1	DMXAA	DMXAA	NNP
cord-259748-x7dq1sy4	601	1	The	the	DT
cord-259748-x7dq1sy4	601	2	STING	sting	NN
cord-259748-x7dq1sy4	601	3	agonist	agonist	NN
cord-259748-x7dq1sy4	601	4	DMXAA	DMXAA	NNP
cord-259748-x7dq1sy4	601	5	triggers	trigger	VBZ
cord-259748-x7dq1sy4	601	6	a	a	DT
cord-259748-x7dq1sy4	601	7	cooperation	cooperation	NN
cord-259748-x7dq1sy4	601	8	between	between	IN
cord-259748-x7dq1sy4	601	9	T	t	NN
cord-259748-x7dq1sy4	601	10	lymphocytes	lymphocyte	NNS
cord-259748-x7dq1sy4	601	11	and	and	CC
cord-259748-x7dq1sy4	601	12	myeloid	myeloid	NN
cord-259748-x7dq1sy4	601	13	cells	cell	NNS
cord-259748-x7dq1sy4	601	14	that	that	WDT
cord-259748-x7dq1sy4	601	15	leads	lead	VBZ
cord-259748-x7dq1sy4	601	16	to	to	TO
cord-259748-x7dq1sy4	601	17	tumor	tumor	NN
cord-259748-x7dq1sy4	601	18	regression	regression	NN
cord-259748-x7dq1sy4	602	1	Randomized	randomized	JJ
cord-259748-x7dq1sy4	602	2	phase	phase	NN
cord-259748-x7dq1sy4	602	3	III	iii	CD
cord-259748-x7dq1sy4	602	4	placebo	placebo	NN
cord-259748-x7dq1sy4	602	5	-	-	HYPH
cord-259748-x7dq1sy4	602	6	controlled	control	VBN
cord-259748-x7dq1sy4	602	7	trial	trial	NN
cord-259748-x7dq1sy4	602	8	of	of	IN
cord-259748-x7dq1sy4	602	9	carboplatin	carboplatin	NNS
cord-259748-x7dq1sy4	602	10	and	and	CC
cord-259748-x7dq1sy4	602	11	paclitaxel	paclitaxel	VBD
cord-259748-x7dq1sy4	602	12	with	with	IN
cord-259748-x7dq1sy4	602	13	or	or	CC
cord-259748-x7dq1sy4	602	14	without	without	IN
cord-259748-x7dq1sy4	602	15	the	the	DT
cord-259748-x7dq1sy4	602	16	vascular	vascular	JJ
cord-259748-x7dq1sy4	602	17	disrupting	disrupt	VBG
cord-259748-x7dq1sy4	602	18	agent	agent	NN
cord-259748-x7dq1sy4	602	19	vadimezan	vadimezan	NNP
cord-259748-x7dq1sy4	603	1	(	(	-LRB-
cord-259748-x7dq1sy4	603	2	ASA404	ASA404	NNP
cord-259748-x7dq1sy4	603	3	)	)	-RRB-
cord-259748-x7dq1sy4	603	4	in	in	IN
cord-259748-x7dq1sy4	603	5	advanced	advanced	JJ
cord-259748-x7dq1sy4	603	6	non	non	JJ
cord-259748-x7dq1sy4	603	7	-	-	JJ
cord-259748-x7dq1sy4	603	8	small	small	JJ
cord-259748-x7dq1sy4	603	9	-	-	HYPH
cord-259748-x7dq1sy4	603	10	cell	cell	NN
cord-259748-x7dq1sy4	603	11	lung	lung	NN
cord-259748-x7dq1sy4	603	12	cancer	cancer	NN
cord-259748-x7dq1sy4	603	13	Design	Design	NNP
cord-259748-x7dq1sy4	603	14	of	of	IN
cord-259748-x7dq1sy4	603	15	amidobenzimidazole	amidobenzimidazole	NNP
cord-259748-x7dq1sy4	603	16	STING	sting	VB
cord-259748-x7dq1sy4	603	17	receptor	receptor	NN
cord-259748-x7dq1sy4	603	18	agonists	agonist	NNS
cord-259748-x7dq1sy4	603	19	with	with	IN
cord-259748-x7dq1sy4	603	20	systemic	systemic	JJ
cord-259748-x7dq1sy4	603	21	activity	activity	NN
cord-259748-x7dq1sy4	603	22	STING	sting	NN
cord-259748-x7dq1sy4	603	23	ligand	ligand	NN
cord-259748-x7dq1sy4	603	24	c	c	NNP
cord-259748-x7dq1sy4	603	25	-	-	HYPH
cord-259748-x7dq1sy4	603	26	di	di	NNP
cord-259748-x7dq1sy4	603	27	-	-	HYPH
cord-259748-x7dq1sy4	603	28	GMP	GMP	NNP
cord-259748-x7dq1sy4	603	29	improves	improve	VBZ
cord-259748-x7dq1sy4	603	30	cancer	cancer	NN
cord-259748-x7dq1sy4	603	31	vaccination	vaccination	NN
cord-259748-x7dq1sy4	603	32	against	against	IN
cord-259748-x7dq1sy4	603	33	metastatic	metastatic	JJ
cord-259748-x7dq1sy4	603	34	breast	breast	NN
cord-259748-x7dq1sy4	603	35	cancer	cancer	NN
cord-259748-x7dq1sy4	604	1	Endosomolytic	Endosomolytic	NNP
cord-259748-x7dq1sy4	604	2	polymersomes	polymersome	NNS
cord-259748-x7dq1sy4	604	3	increase	increase	VBP
cord-259748-x7dq1sy4	604	4	the	the	DT
cord-259748-x7dq1sy4	604	5	activity	activity	NN
cord-259748-x7dq1sy4	604	6	of	of	IN
cord-259748-x7dq1sy4	604	7	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	604	8	dinucleotide	dinucleotide	NN
cord-259748-x7dq1sy4	604	9	STING	sting	NN
cord-259748-x7dq1sy4	604	10	agonists	agonist	NNS
cord-259748-x7dq1sy4	604	11	to	to	TO
cord-259748-x7dq1sy4	604	12	enhance	enhance	VB
cord-259748-x7dq1sy4	604	13	cancer	cancer	NN
cord-259748-x7dq1sy4	604	14	immunotherapy	immunotherapy	NN
cord-259748-x7dq1sy4	604	15	Efficacy	Efficacy	NNP
cord-259748-x7dq1sy4	604	16	of	of	IN
cord-259748-x7dq1sy4	604	17	the	the	DT
cord-259748-x7dq1sy4	604	18	Janus	Janus	NNP
cord-259748-x7dq1sy4	604	19	kinase	kinase	NN
cord-259748-x7dq1sy4	605	1	1	1	LS
cord-259748-x7dq1sy4	605	2	/2	/2	CD
cord-259748-x7dq1sy4	605	3	inhibitor	inhibitor	NN
cord-259748-x7dq1sy4	605	4	ruxolitinib	ruxolitinib	NN
cord-259748-x7dq1sy4	605	5	in	in	IN
cord-259748-x7dq1sy4	605	6	the	the	DT
cord-259748-x7dq1sy4	605	7	treatment	treatment	NN
cord-259748-x7dq1sy4	605	8	of	of	IN
cord-259748-x7dq1sy4	605	9	vasculopathy	vasculopathy	NNP
cord-259748-x7dq1sy4	605	10	associated	associate	VBN
cord-259748-x7dq1sy4	605	11	with	with	IN
cord-259748-x7dq1sy4	605	12	TMEM173-activating	TMEM173-activating	NNP
cord-259748-x7dq1sy4	605	13	mutations	mutation	NNS
cord-259748-x7dq1sy4	605	14	in	in	IN
cord-259748-x7dq1sy4	605	15	3	3	CD
cord-259748-x7dq1sy4	605	16	children	child	NNS
cord-259748-x7dq1sy4	606	1	Suramin	Suramin	NNP
cord-259748-x7dq1sy4	606	2	potently	potently	RB
cord-259748-x7dq1sy4	606	3	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	606	4	cGAMP	cGAMP	NNP
cord-259748-x7dq1sy4	606	5	synthase	synthase	NN
cord-259748-x7dq1sy4	606	6	,	,	,
cord-259748-x7dq1sy4	606	7	cGAS	cgas	NN
cord-259748-x7dq1sy4	606	8	,	,	,
cord-259748-x7dq1sy4	606	9	in	in	IN
cord-259748-x7dq1sy4	606	10	THP1	THP1	NNP
cord-259748-x7dq1sy4	606	11	cells	cell	NNS
cord-259748-x7dq1sy4	606	12	to	to	TO
cord-259748-x7dq1sy4	606	13	modulate	modulate	VB
cord-259748-x7dq1sy4	606	14	IFNbeta	ifnbeta	NN
cord-259748-x7dq1sy4	606	15	levels	level	NNS
cord-259748-x7dq1sy4	606	16	Small	small	JJ
cord-259748-x7dq1sy4	606	17	molecule	molecule	NN
cord-259748-x7dq1sy4	606	18	inhibition	inhibition	NN
cord-259748-x7dq1sy4	606	19	of	of	IN
cord-259748-x7dq1sy4	606	20	cGAS	cgas	JJ
cord-259748-x7dq1sy4	606	21	reduces	reduce	VBZ
cord-259748-x7dq1sy4	606	22	interferon	interferon	JJ
cord-259748-x7dq1sy4	606	23	expression	expression	NN
cord-259748-x7dq1sy4	606	24	in	in	IN
cord-259748-x7dq1sy4	606	25	primary	primary	JJ
cord-259748-x7dq1sy4	606	26	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	606	27	from	from	IN
cord-259748-x7dq1sy4	606	28	autoimmune	autoimmune	JJ
cord-259748-x7dq1sy4	606	29	mice	mouse	NNS
cord-259748-x7dq1sy4	606	30	Development	Development	NNP
cord-259748-x7dq1sy4	606	31	of	of	IN
cord-259748-x7dq1sy4	606	32	human	human	JJ
cord-259748-x7dq1sy4	606	33	cGAS	cgas	NN
cord-259748-x7dq1sy4	606	34	-	-	HYPH
cord-259748-x7dq1sy4	606	35	specific	specific	JJ
cord-259748-x7dq1sy4	606	36	small	small	JJ
cord-259748-x7dq1sy4	606	37	-	-	HYPH
cord-259748-x7dq1sy4	606	38	molecule	molecule	NN
cord-259748-x7dq1sy4	606	39	inhibitors	inhibitor	NNS
cord-259748-x7dq1sy4	606	40	for	for	IN
cord-259748-x7dq1sy4	606	41	repression	repression	NN
cord-259748-x7dq1sy4	606	42	of	of	IN
cord-259748-x7dq1sy4	606	43	dsDNAtriggered	dsdnatriggered	CD
cord-259748-x7dq1sy4	606	44	interferon	interferon	NN
cord-259748-x7dq1sy4	606	45	expression	expression	NN
cord-259748-x7dq1sy4	607	1	The	the	DT
cord-259748-x7dq1sy4	607	2	cyclopeptide	cyclopeptide	NN
cord-259748-x7dq1sy4	607	3	astin	astin	NNP
cord-259748-x7dq1sy4	607	4	C	C	NNP
cord-259748-x7dq1sy4	607	5	specifically	specifically	RB
cord-259748-x7dq1sy4	607	6	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	607	7	the	the	DT
cord-259748-x7dq1sy4	607	8	innate	innate	JJ
cord-259748-x7dq1sy4	607	9	immune	immune	JJ
cord-259748-x7dq1sy4	607	10	CDN	CDN	NNP
cord-259748-x7dq1sy4	607	11	sensor	sensor	NN
cord-259748-x7dq1sy4	607	12	STING	sting	NN
cord-259748-x7dq1sy4	607	13	Targeting	target	VBG
cord-259748-x7dq1sy4	607	14	STING	sting	NN
cord-259748-x7dq1sy4	607	15	with	with	IN
cord-259748-x7dq1sy4	607	16	covalent	covalent	JJ
cord-259748-x7dq1sy4	607	17	small	small	JJ
cord-259748-x7dq1sy4	607	18	-	-	HYPH
cord-259748-x7dq1sy4	607	19	molecule	molecule	NN
cord-259748-x7dq1sy4	607	20	inhibitors	inhibitor	NNS
cord-259748-x7dq1sy4	608	1	TRIM56-mediated	trim56-mediate	VBN
cord-259748-x7dq1sy4	608	2	monoubiquitination	monoubiquitination	NN
cord-259748-x7dq1sy4	608	3	of	of	IN
cord-259748-x7dq1sy4	608	4	cGAS	cgas	NN
cord-259748-x7dq1sy4	608	5	for	for	IN
cord-259748-x7dq1sy4	608	6	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	608	7	DNA	dna	NN
cord-259748-x7dq1sy4	608	8	sensing	sensing	NN
cord-259748-x7dq1sy4	608	9	The	the	DT
cord-259748-x7dq1sy4	608	10	ubiquitin	ubiquitin	NN
cord-259748-x7dq1sy4	608	11	ligase	ligase	NN
cord-259748-x7dq1sy4	609	1	TRIM56	TRIM56	NNP
cord-259748-x7dq1sy4	609	2	regulates	regulate	VBZ
cord-259748-x7dq1sy4	609	3	innate	innate	JJ
cord-259748-x7dq1sy4	609	4	immune	immune	JJ
cord-259748-x7dq1sy4	609	5	responses	response	NNS
cord-259748-x7dq1sy4	609	6	to	to	IN
cord-259748-x7dq1sy4	609	7	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	609	8	doublestranded	doublestranded	JJ
cord-259748-x7dq1sy4	609	9	DNA	dna	NN
cord-259748-x7dq1sy4	610	1	The	the	DT
cord-259748-x7dq1sy4	610	2	E3	e3	NN
cord-259748-x7dq1sy4	610	3	ubiquitin	ubiquitin	NN
cord-259748-x7dq1sy4	610	4	ligase	ligase	NN
cord-259748-x7dq1sy4	611	1	RNF185	RNF185	NNP
cord-259748-x7dq1sy4	611	2	facilitates	facilitate	VBZ
cord-259748-x7dq1sy4	611	3	the	the	DT
cord-259748-x7dq1sy4	611	4	cGAS	cgas	NN
cord-259748-x7dq1sy4	611	5	-	-	HYPH
cord-259748-x7dq1sy4	611	6	mediated	mediate	VBN
cord-259748-x7dq1sy4	611	7	innate	innate	JJ
cord-259748-x7dq1sy4	611	8	immune	immune	JJ
cord-259748-x7dq1sy4	611	9	response	response	NN
cord-259748-x7dq1sy4	611	10	RNF26	RNF26	NNP
cord-259748-x7dq1sy4	611	11	temporally	temporally	RB
cord-259748-x7dq1sy4	611	12	regulates	regulate	VBZ
cord-259748-x7dq1sy4	611	13	virus	virus	NN
cord-259748-x7dq1sy4	611	14	-	-	HYPH
cord-259748-x7dq1sy4	611	15	triggered	trigger	VBN
cord-259748-x7dq1sy4	611	16	type	type	NN
cord-259748-x7dq1sy4	611	17	I	-PRON-	PRP
cord-259748-x7dq1sy4	611	18	interferon	interferon	VBD
cord-259748-x7dq1sy4	611	19	induction	induction	NN
cord-259748-x7dq1sy4	611	20	by	by	IN
cord-259748-x7dq1sy4	611	21	two	two	CD
cord-259748-x7dq1sy4	611	22	distinct	distinct	JJ
cord-259748-x7dq1sy4	611	23	mechanisms	mechanism	NNS
cord-259748-x7dq1sy4	612	1	The	the	DT
cord-259748-x7dq1sy4	612	2	E3	e3	NN
cord-259748-x7dq1sy4	612	3	ubiquitin	ubiquitin	NN
cord-259748-x7dq1sy4	612	4	ligase	ligase	NN
cord-259748-x7dq1sy4	612	5	AMFR	AMFR	NNP
cord-259748-x7dq1sy4	612	6	and	and	CC
cord-259748-x7dq1sy4	612	7	INSIG1	INSIG1	NNP
cord-259748-x7dq1sy4	612	8	bridge	bridge	VBP
cord-259748-x7dq1sy4	612	9	the	the	DT
cord-259748-x7dq1sy4	612	10	activation	activation	NN
cord-259748-x7dq1sy4	612	11	of	of	IN
cord-259748-x7dq1sy4	612	12	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	612	13	kinase	kinase	NN
cord-259748-x7dq1sy4	612	14	by	by	IN
cord-259748-x7dq1sy4	612	15	modifying	modify	VBG
cord-259748-x7dq1sy4	612	16	the	the	DT
cord-259748-x7dq1sy4	612	17	adaptor	adaptor	NN
cord-259748-x7dq1sy4	612	18	STING	sting	NN
cord-259748-x7dq1sy4	613	1	TRIM14	TRIM14	NNP
cord-259748-x7dq1sy4	613	2	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	613	3	cGAS	cgas	JJ
cord-259748-x7dq1sy4	613	4	degradation	degradation	NN
cord-259748-x7dq1sy4	613	5	mediated	mediate	VBN
cord-259748-x7dq1sy4	613	6	by	by	IN
cord-259748-x7dq1sy4	613	7	Selective	selective	JJ
cord-259748-x7dq1sy4	613	8	autophagy	autophagy	NN
cord-259748-x7dq1sy4	613	9	receptor	receptor	NN
cord-259748-x7dq1sy4	613	10	p62	p62	NN
cord-259748-x7dq1sy4	613	11	to	to	TO
cord-259748-x7dq1sy4	613	12	promote	promote	VB
cord-259748-x7dq1sy4	613	13	innate	innate	JJ
cord-259748-x7dq1sy4	613	14	immune	immune	JJ
cord-259748-x7dq1sy4	613	15	responses	response	NNS
cord-259748-x7dq1sy4	613	16	p38	p38	CD
cord-259748-x7dq1sy4	613	17	inhibition	inhibition	NN
cord-259748-x7dq1sy4	613	18	provides	provide	VBZ
cord-259748-x7dq1sy4	613	19	anti	anti	JJ
cord-259748-x7dq1sy4	613	20	-	-	JJ
cord-259748-x7dq1sy4	613	21	DNA	dna	JJ
cord-259748-x7dq1sy4	613	22	virus	virus	NN
cord-259748-x7dq1sy4	613	23	immunity	immunity	NN
cord-259748-x7dq1sy4	613	24	by	by	IN
cord-259748-x7dq1sy4	613	25	regulation	regulation	NN
cord-259748-x7dq1sy4	613	26	of	of	IN
cord-259748-x7dq1sy4	613	27	USP21	USP21	NNP
cord-259748-x7dq1sy4	613	28	phosphorylation	phosphorylation	NN
cord-259748-x7dq1sy4	613	29	and	and	CC
cord-259748-x7dq1sy4	613	30	STING	sting	NN
cord-259748-x7dq1sy4	613	31	activation	activation	NN
cord-259748-x7dq1sy4	613	32	USP18	USP18	NNP
cord-259748-x7dq1sy4	613	33	recruits	recruit	NNS
cord-259748-x7dq1sy4	613	34	USP20	USP20	NNP
cord-259748-x7dq1sy4	613	35	to	to	TO
cord-259748-x7dq1sy4	613	36	promote	promote	VB
cord-259748-x7dq1sy4	613	37	innate	innate	JJ
cord-259748-x7dq1sy4	613	38	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	613	39	response	response	NN
cord-259748-x7dq1sy4	613	40	through	through	IN
cord-259748-x7dq1sy4	613	41	deubiquitinating	deubiquitinate	VBG
cord-259748-x7dq1sy4	613	42	STING	STING	NNP
cord-259748-x7dq1sy4	613	43	/	/	SYM
cord-259748-x7dq1sy4	613	44	MITA	MITA	NNP
cord-259748-x7dq1sy4	614	1	The	the	DT
cord-259748-x7dq1sy4	614	2	deubiquitinase	deubiquitinase	NN
cord-259748-x7dq1sy4	614	3	CYLD	CYLD	NNP
cord-259748-x7dq1sy4	614	4	is	be	VBZ
cord-259748-x7dq1sy4	614	5	a	a	DT
cord-259748-x7dq1sy4	614	6	specific	specific	JJ
cord-259748-x7dq1sy4	614	7	checkpoint	checkpoint	NN
cord-259748-x7dq1sy4	614	8	of	of	IN
cord-259748-x7dq1sy4	614	9	the	the	DT
cord-259748-x7dq1sy4	614	10	STING	sting	NN
cord-259748-x7dq1sy4	614	11	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	615	1	signaling	signal	VBG
cord-259748-x7dq1sy4	615	2	pathway	pathway	NN
cord-259748-x7dq1sy4	615	3	Sumoylation	Sumoylation	NNP
cord-259748-x7dq1sy4	615	4	promotes	promote	VBZ
cord-259748-x7dq1sy4	615	5	the	the	DT
cord-259748-x7dq1sy4	615	6	stability	stability	NN
cord-259748-x7dq1sy4	615	7	of	of	IN
cord-259748-x7dq1sy4	615	8	the	the	DT
cord-259748-x7dq1sy4	615	9	DNA	dna	NN
cord-259748-x7dq1sy4	615	10	sensor	sensor	NN
cord-259748-x7dq1sy4	615	11	cGAS	cgas	NN
cord-259748-x7dq1sy4	615	12	and	and	CC
cord-259748-x7dq1sy4	615	13	the	the	DT
cord-259748-x7dq1sy4	615	14	adaptor	adaptor	NN
cord-259748-x7dq1sy4	615	15	STING	sting	NN
cord-259748-x7dq1sy4	615	16	to	to	TO
cord-259748-x7dq1sy4	615	17	regulate	regulate	VB
cord-259748-x7dq1sy4	615	18	the	the	DT
cord-259748-x7dq1sy4	615	19	kinetics	kinetic	NNS
cord-259748-x7dq1sy4	615	20	of	of	IN
cord-259748-x7dq1sy4	615	21	response	response	NN
cord-259748-x7dq1sy4	615	22	to	to	IN
cord-259748-x7dq1sy4	615	23	DNA	DNA	NNP
cord-259748-x7dq1sy4	615	24	Virus	Virus	NNP
cord-259748-x7dq1sy4	615	25	SENP7	SENP7	NNP
cord-259748-x7dq1sy4	615	26	Potentiates	Potentiates	NNP
cord-259748-x7dq1sy4	615	27	cGAS	cgas	NN
cord-259748-x7dq1sy4	615	28	Activation	Activation	NNP
cord-259748-x7dq1sy4	615	29	by	by	IN
cord-259748-x7dq1sy4	615	30	Relieving	relieve	VBG
cord-259748-x7dq1sy4	615	31	SUMO	SUMO	NNP
cord-259748-x7dq1sy4	615	32	-	-	HYPH
cord-259748-x7dq1sy4	615	33	Mediated	mediate	VBN
cord-259748-x7dq1sy4	615	34	Inhibition	Inhibition	NNP
cord-259748-x7dq1sy4	615	35	of	of	IN
cord-259748-x7dq1sy4	615	36	Cytosolic	Cytosolic	NNP
cord-259748-x7dq1sy4	615	37	DNA	DNA	NNP
cord-259748-x7dq1sy4	615	38	Sensing	Sensing	NNP
cord-259748-x7dq1sy4	615	39	G3BP1	G3BP1	NNP
cord-259748-x7dq1sy4	615	40	promotes	promote	VBZ
cord-259748-x7dq1sy4	615	41	DNA	dna	NN
cord-259748-x7dq1sy4	615	42	binding	binding	NN
cord-259748-x7dq1sy4	615	43	and	and	CC
cord-259748-x7dq1sy4	615	44	activation	activation	NN
cord-259748-x7dq1sy4	615	45	of	of	IN
cord-259748-x7dq1sy4	615	46	cGAS	cgas	NN
cord-259748-x7dq1sy4	615	47	ZCCHC3	ZCCHC3	NNP
cord-259748-x7dq1sy4	615	48	is	be	VBZ
cord-259748-x7dq1sy4	615	49	a	a	DT
cord-259748-x7dq1sy4	615	50	cosensor	cosensor	NN
cord-259748-x7dq1sy4	615	51	of	of	IN
cord-259748-x7dq1sy4	615	52	cGAS	cgas	NN
cord-259748-x7dq1sy4	615	53	for	for	IN
cord-259748-x7dq1sy4	615	54	dsDNA	dsdna	JJ
cord-259748-x7dq1sy4	615	55	recognition	recognition	NN
cord-259748-x7dq1sy4	615	56	in	in	IN
cord-259748-x7dq1sy4	615	57	innate	innate	JJ
cord-259748-x7dq1sy4	615	58	immune	immune	JJ
cord-259748-x7dq1sy4	615	59	response	response	NN
cord-259748-x7dq1sy4	616	1	Manganese	manganese	NN
cord-259748-x7dq1sy4	616	2	increases	increase	VBZ
cord-259748-x7dq1sy4	616	3	the	the	DT
cord-259748-x7dq1sy4	616	4	sensitivity	sensitivity	NN
cord-259748-x7dq1sy4	616	5	of	of	IN
cord-259748-x7dq1sy4	616	6	the	the	DT
cord-259748-x7dq1sy4	616	7	cGAS	cgas	JJ
cord-259748-x7dq1sy4	616	8	-	-	HYPH
cord-259748-x7dq1sy4	616	9	STING	sting	NN
cord-259748-x7dq1sy4	616	10	pathway	pathway	NN
cord-259748-x7dq1sy4	616	11	for	for	IN
cord-259748-x7dq1sy4	616	12	double	double	RB
cord-259748-x7dq1sy4	616	13	-	-	HYPH
cord-259748-x7dq1sy4	616	14	stranded	strand	VBN
cord-259748-x7dq1sy4	616	15	DNA	dna	NN
cord-259748-x7dq1sy4	616	16	and	and	CC
cord-259748-x7dq1sy4	616	17	is	be	VBZ
cord-259748-x7dq1sy4	616	18	required	require	VBN
cord-259748-x7dq1sy4	616	19	for	for	IN
cord-259748-x7dq1sy4	616	20	the	the	DT
cord-259748-x7dq1sy4	616	21	host	host	NN
cord-259748-x7dq1sy4	616	22	defense	defense	NN
cord-259748-x7dq1sy4	616	23	against	against	IN
cord-259748-x7dq1sy4	616	24	DNA	dna	NN
cord-259748-x7dq1sy4	616	25	viruses	virus	NNS
cord-259748-x7dq1sy4	617	1	TMEM203	TMEM203	NNP
cord-259748-x7dq1sy4	617	2	is	be	VBZ
cord-259748-x7dq1sy4	617	3	a	a	DT
cord-259748-x7dq1sy4	617	4	binding	bind	VBG
cord-259748-x7dq1sy4	617	5	partner	partner	NN
cord-259748-x7dq1sy4	617	6	and	and	CC
cord-259748-x7dq1sy4	617	7	regulator	regulator	NN
cord-259748-x7dq1sy4	617	8	of	of	IN
cord-259748-x7dq1sy4	617	9	STING	sting	NN
cord-259748-x7dq1sy4	617	10	-	-	HYPH
cord-259748-x7dq1sy4	617	11	mediated	mediate	VBN
cord-259748-x7dq1sy4	617	12	inflammatory	inflammatory	JJ
cord-259748-x7dq1sy4	617	13	signaling	signaling	NN
cord-259748-x7dq1sy4	617	14	in	in	IN
cord-259748-x7dq1sy4	617	15	macrophages	macrophage	NNS
cord-259748-x7dq1sy4	618	1	The	the	DT
cord-259748-x7dq1sy4	618	2	ERassociated	ERassociated	NNP
cord-259748-x7dq1sy4	618	3	protein	protein	NN
cord-259748-x7dq1sy4	619	1	ZDHHC1	ZDHHC1	NNP
cord-259748-x7dq1sy4	619	2	is	be	VBZ
cord-259748-x7dq1sy4	619	3	a	a	DT
cord-259748-x7dq1sy4	619	4	positive	positive	JJ
cord-259748-x7dq1sy4	619	5	regulator	regulator	NN
cord-259748-x7dq1sy4	619	6	of	of	IN
cord-259748-x7dq1sy4	619	7	DNA	dna	NN
cord-259748-x7dq1sy4	619	8	virus	virus	NN
cord-259748-x7dq1sy4	619	9	-	-	HYPH
cord-259748-x7dq1sy4	619	10	triggered	trigger	VBN
cord-259748-x7dq1sy4	619	11	,	,	,
cord-259748-x7dq1sy4	619	12	MITA	MITA	NNP
cord-259748-x7dq1sy4	619	13	/	/	SYM
cord-259748-x7dq1sy4	619	14	STING	sting	NN
cord-259748-x7dq1sy4	619	15	-	-	HYPH
cord-259748-x7dq1sy4	619	16	dependent	dependent	JJ
cord-259748-x7dq1sy4	619	17	innate	innate	JJ
cord-259748-x7dq1sy4	619	18	immune	immune	NN
cord-259748-x7dq1sy4	619	19	signaling	signal	VBG
cord-259748-x7dq1sy4	619	20	Association	Association	NNP
cord-259748-x7dq1sy4	619	21	of	of	IN
cord-259748-x7dq1sy4	619	22	Abnormal	abnormal	JJ
cord-259748-x7dq1sy4	619	23	Elevations	elevation	NNS
cord-259748-x7dq1sy4	619	24	in	in	IN
cord-259748-x7dq1sy4	619	25	IFIT3	ifit3	NN
cord-259748-x7dq1sy4	620	1	With	with	IN
cord-259748-x7dq1sy4	620	2	Overactive	overactive	JJ
cord-259748-x7dq1sy4	620	3	Cyclic	cyclic	JJ
cord-259748-x7dq1sy4	620	4	GMP	GMP	NNP
cord-259748-x7dq1sy4	620	5	-	-	HYPH
cord-259748-x7dq1sy4	620	6	AMP	AMP	NNP
cord-259748-x7dq1sy4	620	7	Synthase	Synthase	NNP
cord-259748-x7dq1sy4	620	8	/	/	SYM
cord-259748-x7dq1sy4	620	9	Stimulator	Stimulator	NNP
cord-259748-x7dq1sy4	620	10	of	of	IN
cord-259748-x7dq1sy4	620	11	Interferon	Interferon	NNP
cord-259748-x7dq1sy4	620	12	Genes	Genes	NNP
cord-259748-x7dq1sy4	620	13	Signaling	signal	VBG
cord-259748-x7dq1sy4	620	14	in	in	IN
cord-259748-x7dq1sy4	620	15	Human	human	JJ
cord-259748-x7dq1sy4	620	16	Systemic	Systemic	NNP
cord-259748-x7dq1sy4	620	17	Lupus	Lupus	NNP
cord-259748-x7dq1sy4	620	18	Erythematosus	Erythematosus	NNP
cord-259748-x7dq1sy4	620	19	Monocytes	Monocytes	NNPS
cord-259748-x7dq1sy4	621	1	S6K	s6k	VB
cord-259748-x7dq1sy4	621	2	-	-	HYPH
cord-259748-x7dq1sy4	621	3	STING	sting	NN
cord-259748-x7dq1sy4	621	4	interaction	interaction	NN
cord-259748-x7dq1sy4	621	5	regulates	regulate	VBZ
cord-259748-x7dq1sy4	621	6	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	621	7	DNA	dna	NN
cord-259748-x7dq1sy4	621	8	-	-	HYPH
cord-259748-x7dq1sy4	621	9	mediated	mediate	VBN
cord-259748-x7dq1sy4	621	10	activation	activation	NN
cord-259748-x7dq1sy4	621	11	of	of	IN
cord-259748-x7dq1sy4	621	12	the	the	DT
cord-259748-x7dq1sy4	621	13	transcription	transcription	NN
cord-259748-x7dq1sy4	621	14	factor	factor	NN
cord-259748-x7dq1sy4	622	1	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	622	2	Glycogen	Glycogen	NNP
cord-259748-x7dq1sy4	622	3	synthase	synthase	NN
cord-259748-x7dq1sy4	622	4	kinase	kinase	NN
cord-259748-x7dq1sy4	622	5	3beta	3beta	NN
cord-259748-x7dq1sy4	622	6	regulates	regulate	VBZ
cord-259748-x7dq1sy4	622	7	IRF3	IRF3	NNP
cord-259748-x7dq1sy4	622	8	transcription	transcription	NN
cord-259748-x7dq1sy4	622	9	factor	factor	NN
cord-259748-x7dq1sy4	622	10	-	-	HYPH
cord-259748-x7dq1sy4	622	11	mediated	mediate	VBN
cord-259748-x7dq1sy4	622	12	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	622	13	response	response	NN
cord-259748-x7dq1sy4	622	14	via	via	IN
cord-259748-x7dq1sy4	622	15	activation	activation	NN
cord-259748-x7dq1sy4	622	16	of	of	IN
cord-259748-x7dq1sy4	622	17	the	the	DT
cord-259748-x7dq1sy4	622	18	kinase	kinase	NN
cord-259748-x7dq1sy4	622	19	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	622	20	TRIM9	TRIM9	NNP
cord-259748-x7dq1sy4	622	21	short	short	JJ
cord-259748-x7dq1sy4	622	22	isoform	isoform	NN
cord-259748-x7dq1sy4	622	23	preferentially	preferentially	RB
cord-259748-x7dq1sy4	622	24	promotes	promote	VBZ
cord-259748-x7dq1sy4	622	25	DNA	DNA	NNP
cord-259748-x7dq1sy4	622	26	and	and	CC
cord-259748-x7dq1sy4	622	27	RNA	RNA	NNP
cord-259748-x7dq1sy4	622	28	virus	virus	NN
cord-259748-x7dq1sy4	622	29	-	-	HYPH
cord-259748-x7dq1sy4	622	30	induced	induce	VBN
cord-259748-x7dq1sy4	622	31	production	production	NN
cord-259748-x7dq1sy4	622	32	of	of	IN
cord-259748-x7dq1sy4	622	33	type	type	NN
cord-259748-x7dq1sy4	623	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	623	2	interferon	interferon	RB
cord-259748-x7dq1sy4	624	1	by	by	IN
cord-259748-x7dq1sy4	624	2	recruiting	recruit	VBG
cord-259748-x7dq1sy4	624	3	GSK3beta	GSK3beta	NNP
cord-259748-x7dq1sy4	624	4	to	to	IN
cord-259748-x7dq1sy4	624	5	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	624	6	LSm14A	LSm14A	NNP
cord-259748-x7dq1sy4	624	7	plays	play	VBZ
cord-259748-x7dq1sy4	624	8	a	a	DT
cord-259748-x7dq1sy4	624	9	critical	critical	JJ
cord-259748-x7dq1sy4	624	10	role	role	NN
cord-259748-x7dq1sy4	624	11	in	in	IN
cord-259748-x7dq1sy4	624	12	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	624	13	immune	immune	JJ
cord-259748-x7dq1sy4	624	14	responses	response	NNS
cord-259748-x7dq1sy4	624	15	by	by	IN
cord-259748-x7dq1sy4	624	16	regulating	regulate	VBG
cord-259748-x7dq1sy4	624	17	MITA	MITA	NNP
cord-259748-x7dq1sy4	624	18	level	level	NN
cord-259748-x7dq1sy4	624	19	in	in	IN
cord-259748-x7dq1sy4	624	20	a	a	DT
cord-259748-x7dq1sy4	624	21	cell	cell	NN
cord-259748-x7dq1sy4	624	22	-	-	HYPH
cord-259748-x7dq1sy4	624	23	specific	specific	JJ
cord-259748-x7dq1sy4	624	24	manner	manner	NN
cord-259748-x7dq1sy4	625	1	TRIM29	TRIM29	NNP
cord-259748-x7dq1sy4	625	2	promotes	promote	VBZ
cord-259748-x7dq1sy4	625	3	DNA	dna	NN
cord-259748-x7dq1sy4	625	4	virus	virus	NN
cord-259748-x7dq1sy4	625	5	infections	infection	NNS
cord-259748-x7dq1sy4	625	6	by	by	IN
cord-259748-x7dq1sy4	625	7	inhibiting	inhibit	VBG
cord-259748-x7dq1sy4	625	8	innate	innate	JJ
cord-259748-x7dq1sy4	625	9	immune	immune	JJ
cord-259748-x7dq1sy4	625	10	response	response	NN
cord-259748-x7dq1sy4	626	1	TRIM30alpha	TRIM30alpha	NNP
cord-259748-x7dq1sy4	626	2	is	be	VBZ
cord-259748-x7dq1sy4	626	3	a	a	DT
cord-259748-x7dq1sy4	626	4	negative	negative	JJ
cord-259748-x7dq1sy4	626	5	-	-	HYPH
cord-259748-x7dq1sy4	626	6	feedback	feedback	NN
cord-259748-x7dq1sy4	626	7	regulator	regulator	NN
cord-259748-x7dq1sy4	626	8	of	of	IN
cord-259748-x7dq1sy4	626	9	the	the	DT
cord-259748-x7dq1sy4	626	10	intracellular	intracellular	JJ
cord-259748-x7dq1sy4	626	11	DNA	dna	NN
cord-259748-x7dq1sy4	626	12	and	and	CC
cord-259748-x7dq1sy4	626	13	DNA	dna	NN
cord-259748-x7dq1sy4	626	14	virustriggered	virustriggere	VBN
cord-259748-x7dq1sy4	626	15	response	response	NN
cord-259748-x7dq1sy4	626	16	by	by	IN
cord-259748-x7dq1sy4	626	17	targeting	target	VBG
cord-259748-x7dq1sy4	626	18	STING	sting	NN
cord-259748-x7dq1sy4	627	1	The	the	DT
cord-259748-x7dq1sy4	627	2	ubiquitin	ubiquitin	NN
cord-259748-x7dq1sy4	627	3	ligase	ligase	NN
cord-259748-x7dq1sy4	627	4	RNF5	RNF5	NNP
cord-259748-x7dq1sy4	627	5	regulates	regulate	VBZ
cord-259748-x7dq1sy4	627	6	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	627	7	responses	response	NNS
cord-259748-x7dq1sy4	627	8	by	by	IN
cord-259748-x7dq1sy4	627	9	mediating	mediate	VBG
cord-259748-x7dq1sy4	627	10	degradation	degradation	NN
cord-259748-x7dq1sy4	627	11	of	of	IN
cord-259748-x7dq1sy4	627	12	the	the	DT
cord-259748-x7dq1sy4	627	13	adaptor	adaptor	NN
cord-259748-x7dq1sy4	627	14	protein	protein	NN
cord-259748-x7dq1sy4	627	15	MITA	MITA	NNP
cord-259748-x7dq1sy4	627	16	USP13	usp13	RB
cord-259748-x7dq1sy4	627	17	negatively	negatively	RB
cord-259748-x7dq1sy4	627	18	regulates	regulate	VBZ
cord-259748-x7dq1sy4	627	19	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	627	20	responses	response	NNS
cord-259748-x7dq1sy4	627	21	by	by	IN
cord-259748-x7dq1sy4	627	22	deubiquitinating	deubiquitinate	VBG
cord-259748-x7dq1sy4	627	23	STING	STING	NNP
cord-259748-x7dq1sy4	628	1	Oligoadenylatesynthetase	Oligoadenylatesynthetase	NNP
cord-259748-x7dq1sy4	628	2	-	-	HYPH
cord-259748-x7dq1sy4	628	3	family	family	NN
cord-259748-x7dq1sy4	628	4	protein	protein	NN
cord-259748-x7dq1sy4	628	5	OASL	OASL	NNP
cord-259748-x7dq1sy4	628	6	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	628	7	activity	activity	NN
cord-259748-x7dq1sy4	628	8	of	of	IN
cord-259748-x7dq1sy4	628	9	the	the	DT
cord-259748-x7dq1sy4	628	10	DNA	dna	NN
cord-259748-x7dq1sy4	628	11	sensor	sensor	NN
cord-259748-x7dq1sy4	628	12	cGAS	cgas	NN
cord-259748-x7dq1sy4	629	1	during	during	IN
cord-259748-x7dq1sy4	629	2	DNA	dna	NN
cord-259748-x7dq1sy4	629	3	virus	virus	NN
cord-259748-x7dq1sy4	629	4	infection	infection	NN
cord-259748-x7dq1sy4	629	5	to	to	TO
cord-259748-x7dq1sy4	629	6	limit	limit	VB
cord-259748-x7dq1sy4	629	7	interferon	interferon	NN
cord-259748-x7dq1sy4	629	8	production	production	NN
cord-259748-x7dq1sy4	629	9	Interactome	Interactome	NNP
cord-259748-x7dq1sy4	629	10	and	and	CC
cord-259748-x7dq1sy4	629	11	proteome	proteome	NN
cord-259748-x7dq1sy4	629	12	dynamics	dynamic	NNS
cord-259748-x7dq1sy4	629	13	uncover	uncover	VBP
cord-259748-x7dq1sy4	629	14	immune	immune	JJ
cord-259748-x7dq1sy4	629	15	modulatory	modulatory	JJ
cord-259748-x7dq1sy4	629	16	associations	association	NNS
cord-259748-x7dq1sy4	629	17	of	of	IN
cord-259748-x7dq1sy4	629	18	the	the	DT
cord-259748-x7dq1sy4	629	19	pathogen	pathogen	NN
cord-259748-x7dq1sy4	629	20	sensing	sensing	NN
cord-259748-x7dq1sy4	629	21	factor	factor	NN
cord-259748-x7dq1sy4	630	1	cGAS	cGAS	NNP
cord-259748-x7dq1sy4	630	2	Sensing	sensing	NN
cord-259748-x7dq1sy4	630	3	of	of	IN
cord-259748-x7dq1sy4	630	4	bacterial	bacterial	JJ
cord-259748-x7dq1sy4	630	5	cyclic	cyclic	JJ
cord-259748-x7dq1sy4	630	6	dinucleotides	dinucleotide	NNS
cord-259748-x7dq1sy4	630	7	by	by	IN
cord-259748-x7dq1sy4	630	8	the	the	DT
cord-259748-x7dq1sy4	630	9	oxidoreductase	oxidoreductase	NNP
cord-259748-x7dq1sy4	630	10	RECON	RECON	NNP
cord-259748-x7dq1sy4	630	11	promotes	promote	VBZ
cord-259748-x7dq1sy4	630	12	NF	NF	NNP
cord-259748-x7dq1sy4	630	13	-	-	HYPH
cord-259748-x7dq1sy4	630	14	kappaB	kappaB	NNP
cord-259748-x7dq1sy4	630	15	activation	activation	NN
cord-259748-x7dq1sy4	630	16	and	and	CC
cord-259748-x7dq1sy4	630	17	shapes	shape	VBZ
cord-259748-x7dq1sy4	630	18	a	a	DT
cord-259748-x7dq1sy4	630	19	proinflammatory	proinflammatory	JJ
cord-259748-x7dq1sy4	630	20	antibacterial	antibacterial	JJ
cord-259748-x7dq1sy4	630	21	state	state	NN
cord-259748-x7dq1sy4	631	1	The	the	DT
cord-259748-x7dq1sy4	631	2	Ca(2	Ca(2	NNP
cord-259748-x7dq1sy4	631	3	+	+	CC
cord-259748-x7dq1sy4	631	4	)	)	-RRB-
cord-259748-x7dq1sy4	632	1	sensor	sensor	NNP
cord-259748-x7dq1sy4	632	2	STIM1	STIM1	NNP
cord-259748-x7dq1sy4	632	3	regulates	regulate	VBZ
cord-259748-x7dq1sy4	632	4	the	the	DT
cord-259748-x7dq1sy4	632	5	type	type	NN
cord-259748-x7dq1sy4	633	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	633	2	interferon	interferon	VBD
cord-259748-x7dq1sy4	633	3	response	response	NN
cord-259748-x7dq1sy4	633	4	by	by	IN
cord-259748-x7dq1sy4	633	5	retaining	retain	VBG
cord-259748-x7dq1sy4	633	6	the	the	DT
cord-259748-x7dq1sy4	633	7	signaling	signal	VBG
cord-259748-x7dq1sy4	633	8	adaptor	adaptor	NN
cord-259748-x7dq1sy4	633	9	STING	sting	NN
cord-259748-x7dq1sy4	633	10	at	at	IN
cord-259748-x7dq1sy4	633	11	the	the	DT
cord-259748-x7dq1sy4	633	12	endoplasmic	endoplasmic	NN
cord-259748-x7dq1sy4	633	13	reticulum	reticulum	NN
cord-259748-x7dq1sy4	633	14	Nitro	nitro	NN
cord-259748-x7dq1sy4	633	15	-	-	HYPH
cord-259748-x7dq1sy4	633	16	fatty	fatty	JJ
cord-259748-x7dq1sy4	633	17	acids	acid	NNS
cord-259748-x7dq1sy4	633	18	are	be	VBP
cord-259748-x7dq1sy4	633	19	formed	form	VBN
cord-259748-x7dq1sy4	633	20	in	in	IN
cord-259748-x7dq1sy4	633	21	response	response	NN
cord-259748-x7dq1sy4	633	22	to	to	IN
cord-259748-x7dq1sy4	633	23	virus	virus	NN
cord-259748-x7dq1sy4	633	24	infection	infection	NN
cord-259748-x7dq1sy4	633	25	and	and	CC
cord-259748-x7dq1sy4	633	26	are	be	VBP
cord-259748-x7dq1sy4	633	27	potent	potent	JJ
cord-259748-x7dq1sy4	633	28	inhibitors	inhibitor	NNS
cord-259748-x7dq1sy4	633	29	of	of	IN
cord-259748-x7dq1sy4	633	30	STING	STING	NNP
cord-259748-x7dq1sy4	633	31	palmitoylation	palmitoylation	NN
cord-259748-x7dq1sy4	633	32	and	and	CC
cord-259748-x7dq1sy4	633	33	signaling	signal	VBG
cord-259748-x7dq1sy4	633	34	NLRC3	NLRC3	NNP
cord-259748-x7dq1sy4	633	35	,	,	,
cord-259748-x7dq1sy4	633	36	a	a	DT
cord-259748-x7dq1sy4	633	37	member	member	NN
cord-259748-x7dq1sy4	633	38	of	of	IN
cord-259748-x7dq1sy4	633	39	the	the	DT
cord-259748-x7dq1sy4	633	40	NLR	NLR	NNP
cord-259748-x7dq1sy4	633	41	family	family	NN
cord-259748-x7dq1sy4	633	42	of	of	IN
cord-259748-x7dq1sy4	633	43	proteins	protein	NNS
cord-259748-x7dq1sy4	633	44	,	,	,
cord-259748-x7dq1sy4	633	45	is	be	VBZ
cord-259748-x7dq1sy4	633	46	a	a	DT
cord-259748-x7dq1sy4	633	47	negative	negative	JJ
cord-259748-x7dq1sy4	633	48	regulator	regulator	NN
cord-259748-x7dq1sy4	633	49	of	of	IN
cord-259748-x7dq1sy4	633	50	innate	innate	JJ
cord-259748-x7dq1sy4	633	51	immune	immune	JJ
cord-259748-x7dq1sy4	633	52	signaling	signaling	NN
cord-259748-x7dq1sy4	633	53	induced	induce	VBN
cord-259748-x7dq1sy4	633	54	by	by	IN
cord-259748-x7dq1sy4	633	55	the	the	DT
cord-259748-x7dq1sy4	633	56	DNA	dna	NN
cord-259748-x7dq1sy4	633	57	sensor	sensor	NN
cord-259748-x7dq1sy4	633	58	STING	sting	NN
cord-259748-x7dq1sy4	633	59	PPM1A	PPM1A	NNS
cord-259748-x7dq1sy4	633	60	regulates	regulate	VBZ
cord-259748-x7dq1sy4	633	61	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	633	62	signaling	signal	VBG
cord-259748-x7dq1sy4	633	63	by	by	IN
cord-259748-x7dq1sy4	633	64	antagonizing	antagonize	VBG
cord-259748-x7dq1sy4	633	65	TBK1-mediated	TBK1-mediated	NNP
cord-259748-x7dq1sy4	633	66	STING	sting	NN
cord-259748-x7dq1sy4	633	67	phosphorylation	phosphorylation	NN
cord-259748-x7dq1sy4	633	68	and	and	CC
cord-259748-x7dq1sy4	633	69	aggregation	aggregation	NN
cord-259748-x7dq1sy4	634	1	PTPN1/2-mediated	ptpn1/2-mediated	JJ
cord-259748-x7dq1sy4	634	2	dephosphorylation	dephosphorylation	NN
cord-259748-x7dq1sy4	634	3	of	of	IN
cord-259748-x7dq1sy4	634	4	MITA	MITA	NNP
cord-259748-x7dq1sy4	634	5	/	/	SYM
cord-259748-x7dq1sy4	634	6	STING	STING	NNP
cord-259748-x7dq1sy4	634	7	promotes	promote	VBZ
cord-259748-x7dq1sy4	634	8	its	-PRON-	PRP$
cord-259748-x7dq1sy4	634	9	20S	20s	CD
cord-259748-x7dq1sy4	634	10	proteasomal	proteasomal	JJ
cord-259748-x7dq1sy4	634	11	degradation	degradation	NN
cord-259748-x7dq1sy4	634	12	and	and	CC
cord-259748-x7dq1sy4	634	13	attenuates	attenuate	VBZ
cord-259748-x7dq1sy4	634	14	innate	innate	JJ
cord-259748-x7dq1sy4	634	15	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	634	16	response	response	NN
cord-259748-x7dq1sy4	635	1	NLRX1	NLRX1	NNP
cord-259748-x7dq1sy4	635	2	sequesters	sequester	VBZ
cord-259748-x7dq1sy4	635	3	STING	sting	VBP
cord-259748-x7dq1sy4	635	4	to	to	TO
cord-259748-x7dq1sy4	635	5	negatively	negatively	RB
cord-259748-x7dq1sy4	635	6	regulate	regulate	VB
cord-259748-x7dq1sy4	635	7	the	the	DT
cord-259748-x7dq1sy4	635	8	interferon	interferon	NN
cord-259748-x7dq1sy4	635	9	response	response	NN
cord-259748-x7dq1sy4	635	10	,	,	,
cord-259748-x7dq1sy4	635	11	thereby	thereby	RB
cord-259748-x7dq1sy4	635	12	facilitating	facilitate	VBG
cord-259748-x7dq1sy4	635	13	the	the	DT
cord-259748-x7dq1sy4	635	14	replication	replication	NN
cord-259748-x7dq1sy4	635	15	of	of	IN
cord-259748-x7dq1sy4	635	16	HIV-1	HIV-1	NNP
cord-259748-x7dq1sy4	635	17	and	and	CC
cord-259748-x7dq1sy4	635	18	DNA	dna	NN
cord-259748-x7dq1sy4	635	19	viruses	virus	NNS
cord-259748-x7dq1sy4	636	1	NLRX1	NLRX1	NNP
cord-259748-x7dq1sy4	636	2	promotes	promote	VBZ
cord-259748-x7dq1sy4	636	3	immediate	immediate	JJ
cord-259748-x7dq1sy4	636	4	IRF1-directed	irf1-directe	VBN
cord-259748-x7dq1sy4	636	5	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	636	6	responses	response	NNS
cord-259748-x7dq1sy4	636	7	by	by	IN
cord-259748-x7dq1sy4	636	8	limiting	limit	VBG
cord-259748-x7dq1sy4	636	9	dsRNAactivated	dsrnaactivated	JJ
cord-259748-x7dq1sy4	636	10	translational	translational	JJ
cord-259748-x7dq1sy4	636	11	inhibition	inhibition	NN
cord-259748-x7dq1sy4	636	12	mediated	mediate	VBN
cord-259748-x7dq1sy4	636	13	by	by	IN
cord-259748-x7dq1sy4	636	14	PKR	PKR	NNP
cord-259748-x7dq1sy4	636	15	Mitigating	mitigate	VBG
cord-259748-x7dq1sy4	636	16	SOX2-potentiated	sox2-potentiate	VBN
cord-259748-x7dq1sy4	636	17	immune	immune	JJ
cord-259748-x7dq1sy4	636	18	escape	escape	NN
cord-259748-x7dq1sy4	636	19	of	of	IN
cord-259748-x7dq1sy4	636	20	head	head	NN
cord-259748-x7dq1sy4	636	21	and	and	CC
cord-259748-x7dq1sy4	636	22	neck	neck	NN
cord-259748-x7dq1sy4	636	23	squamous	squamous	JJ
cord-259748-x7dq1sy4	636	24	cell	cell	NN
cord-259748-x7dq1sy4	636	25	carcinoma	carcinoma	NN
cord-259748-x7dq1sy4	636	26	with	with	IN
cord-259748-x7dq1sy4	636	27	a	a	DT
cord-259748-x7dq1sy4	636	28	STING	sting	NN
cord-259748-x7dq1sy4	636	29	-	-	HYPH
cord-259748-x7dq1sy4	636	30	inducing	induce	VBG
cord-259748-x7dq1sy4	636	31	nanosatellite	nanosatellite	JJ
cord-259748-x7dq1sy4	636	32	vaccine	vaccine	NN
cord-259748-x7dq1sy4	637	1	mediates	mediate	VBZ
cord-259748-x7dq1sy4	637	2	hypoxia	hypoxia	NN
cord-259748-x7dq1sy4	637	3	-	-	HYPH
cord-259748-x7dq1sy4	637	4	induced	induce	VBN
cord-259748-x7dq1sy4	637	5	immunosuppression	immunosuppression	NN
cord-259748-x7dq1sy4	637	6	by	by	IN
cord-259748-x7dq1sy4	637	7	repressing	repress	VBG
cord-259748-x7dq1sy4	637	8	cGAS	cgas	JJ
cord-259748-x7dq1sy4	637	9	Nrf2	Nrf2	NNP
cord-259748-x7dq1sy4	637	10	negatively	negatively	RB
cord-259748-x7dq1sy4	637	11	regulates	regulate	VBZ
cord-259748-x7dq1sy4	637	12	STING	sting	NN
cord-259748-x7dq1sy4	637	13	indicating	indicate	VBG
cord-259748-x7dq1sy4	637	14	a	a	DT
cord-259748-x7dq1sy4	637	15	link	link	NN
cord-259748-x7dq1sy4	637	16	between	between	IN
cord-259748-x7dq1sy4	637	17	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	637	18	sensing	sensing	NN
cord-259748-x7dq1sy4	637	19	and	and	CC
cord-259748-x7dq1sy4	637	20	metabolic	metabolic	JJ
cord-259748-x7dq1sy4	637	21	reprogramming	reprogramme	VBG
cord-259748-x7dq1sy4	637	22	KDM5	KDM5	NNP
cord-259748-x7dq1sy4	637	23	histone	histone	NN
cord-259748-x7dq1sy4	637	24	demethylases	demethylases	NNP
cord-259748-x7dq1sy4	637	25	repress	repress	VBP
cord-259748-x7dq1sy4	637	26	immune	immune	JJ
cord-259748-x7dq1sy4	637	27	response	response	NN
cord-259748-x7dq1sy4	637	28	via	via	IN
cord-259748-x7dq1sy4	637	29	suppression	suppression	NN
cord-259748-x7dq1sy4	637	30	of	of	IN
cord-259748-x7dq1sy4	637	31	STING	STING	NNP
cord-259748-x7dq1sy4	637	32	Herpes	Herpes	NNP
cord-259748-x7dq1sy4	637	33	simplex	simplex	NN
cord-259748-x7dq1sy4	637	34	virus	virus	NN
cord-259748-x7dq1sy4	637	35	1	1	CD
cord-259748-x7dq1sy4	638	1	abrogates	abrogate	VBZ
cord-259748-x7dq1sy4	638	2	the	the	DT
cord-259748-x7dq1sy4	638	3	cGAS	cgas	JJ
cord-259748-x7dq1sy4	638	4	/	/	SYM
cord-259748-x7dq1sy4	638	5	STING	sting	NN
cord-259748-x7dq1sy4	638	6	-	-	HYPH
cord-259748-x7dq1sy4	638	7	mediated	mediate	VBN
cord-259748-x7dq1sy4	638	8	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	638	9	DNA	dna	NN
cord-259748-x7dq1sy4	638	10	-	-	HYPH
cord-259748-x7dq1sy4	638	11	sensing	sense	VBG
cord-259748-x7dq1sy4	638	12	pathway	pathway	NN
cord-259748-x7dq1sy4	638	13	via	via	IN
cord-259748-x7dq1sy4	638	14	its	-PRON-	PRP$
cord-259748-x7dq1sy4	638	15	virion	virion	NN
cord-259748-x7dq1sy4	638	16	host	host	NN
cord-259748-x7dq1sy4	638	17	shutoff	shutoff	NN
cord-259748-x7dq1sy4	638	18	protein	protein	NN
cord-259748-x7dq1sy4	638	19	,	,	,
cord-259748-x7dq1sy4	638	20	UL41	UL41	NNP
cord-259748-x7dq1sy4	638	21	Herpes	Herpes	NNP
cord-259748-x7dq1sy4	638	22	simplex	simplex	NN
cord-259748-x7dq1sy4	638	23	virus	virus	NN
cord-259748-x7dq1sy4	638	24	1	1	CD
cord-259748-x7dq1sy4	639	1	Tegument	Tegument	NNP
cord-259748-x7dq1sy4	639	2	Protein	Protein	NNP
cord-259748-x7dq1sy4	639	3	VP22	VP22	NNP
cord-259748-x7dq1sy4	639	4	abrogates	abrogate	VBZ
cord-259748-x7dq1sy4	639	5	cGAS	cga	VBD
cord-259748-x7dq1sy4	639	6	/	/	SYM
cord-259748-x7dq1sy4	639	7	STING	sting	NN
cord-259748-x7dq1sy4	639	8	-	-	HYPH
cord-259748-x7dq1sy4	639	9	mediated	mediate	VBN
cord-259748-x7dq1sy4	639	10	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	639	11	innate	innate	JJ
cord-259748-x7dq1sy4	639	12	immunity	immunity	NN
cord-259748-x7dq1sy4	639	13	Species	species	NN
cord-259748-x7dq1sy4	639	14	-	-	HYPH
cord-259748-x7dq1sy4	639	15	specific	specific	JJ
cord-259748-x7dq1sy4	639	16	deamidation	deamidation	NN
cord-259748-x7dq1sy4	639	17	of	of	IN
cord-259748-x7dq1sy4	639	18	cGAS	cgas	NN
cord-259748-x7dq1sy4	639	19	by	by	IN
cord-259748-x7dq1sy4	639	20	herpes	herpes	NNP
cord-259748-x7dq1sy4	639	21	simplex	simplex	NNP
cord-259748-x7dq1sy4	639	22	virus	virus	NN
cord-259748-x7dq1sy4	640	1	UL37	UL37	NNP
cord-259748-x7dq1sy4	640	2	protein	protein	NN
cord-259748-x7dq1sy4	640	3	facilitates	facilitate	VBZ
cord-259748-x7dq1sy4	640	4	viral	viral	JJ
cord-259748-x7dq1sy4	640	5	replication	replication	NN
cord-259748-x7dq1sy4	640	6	Evasion	evasion	NN
cord-259748-x7dq1sy4	640	7	of	of	IN
cord-259748-x7dq1sy4	640	8	the	the	DT
cord-259748-x7dq1sy4	640	9	STING	sting	NN
cord-259748-x7dq1sy4	640	10	DNA	dna	NN
cord-259748-x7dq1sy4	640	11	-	-	HYPH
cord-259748-x7dq1sy4	640	12	sensing	sense	VBG
cord-259748-x7dq1sy4	640	13	pathway	pathway	NN
cord-259748-x7dq1sy4	640	14	by	by	IN
cord-259748-x7dq1sy4	640	15	VP11/12	vp11/12	CD
cord-259748-x7dq1sy4	640	16	of	of	IN
cord-259748-x7dq1sy4	640	17	Herpes	Herpes	NNP
cord-259748-x7dq1sy4	640	18	simplex	simplex	NN
cord-259748-x7dq1sy4	640	19	virus	virus	NN
cord-259748-x7dq1sy4	640	20	1	1	CD
cord-259748-x7dq1sy4	640	21	Herpes	Herpes	NNP
cord-259748-x7dq1sy4	640	22	simplex	simplex	NN
cord-259748-x7dq1sy4	640	23	virus	virus	NN
cord-259748-x7dq1sy4	641	1	1	1	LS
cord-259748-x7dq1sy4	641	2	gamma134.5	gamma134.5	NN
cord-259748-x7dq1sy4	641	3	protein	protein	NN
cord-259748-x7dq1sy4	641	4	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	641	5	STING	sting	NN
cord-259748-x7dq1sy4	641	6	activation	activation	NN
cord-259748-x7dq1sy4	641	7	that	that	WDT
cord-259748-x7dq1sy4	641	8	restricts	restrict	VBZ
cord-259748-x7dq1sy4	641	9	viral	viral	JJ
cord-259748-x7dq1sy4	641	10	replication	replication	NN
cord-259748-x7dq1sy4	641	11	Human	Human	NNP
cord-259748-x7dq1sy4	641	12	Cytomegalovirus	Cytomegalovirus	NNP
cord-259748-x7dq1sy4	641	13	Protein	Protein	NNP
cord-259748-x7dq1sy4	641	14	UL31	UL31	NNP
cord-259748-x7dq1sy4	641	15	Inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	641	16	DNA	DNA	NNP
cord-259748-x7dq1sy4	641	17	Sensing	sensing	NN
cord-259748-x7dq1sy4	641	18	of	of	IN
cord-259748-x7dq1sy4	641	19	cGAS	cgas	NN
cord-259748-x7dq1sy4	641	20	to	to	TO
cord-259748-x7dq1sy4	641	21	Mediate	mediate	VB
cord-259748-x7dq1sy4	641	22	Immune	immune	JJ
cord-259748-x7dq1sy4	641	23	Evasion	evasion	NN
cord-259748-x7dq1sy4	641	24	Type	type	NN
cord-259748-x7dq1sy4	642	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	643	1	interferon	interferon	NN
cord-259748-x7dq1sy4	643	2	production	production	NN
cord-259748-x7dq1sy4	643	3	by	by	IN
cord-259748-x7dq1sy4	643	4	inactivating	inactivate	VBG
cord-259748-x7dq1sy4	643	5	the	the	DT
cord-259748-x7dq1sy4	643	6	DNA	dna	NN
cord-259748-x7dq1sy4	643	7	sensor	sensor	NN
cord-259748-x7dq1sy4	643	8	cGAS	cgas	NN
cord-259748-x7dq1sy4	643	9	without	without	IN
cord-259748-x7dq1sy4	643	10	affecting	affect	VBG
cord-259748-x7dq1sy4	643	11	STING	sting	NN
cord-259748-x7dq1sy4	643	12	Essential	essential	JJ
cord-259748-x7dq1sy4	643	13	role	role	NN
cord-259748-x7dq1sy4	643	14	of	of	IN
cord-259748-x7dq1sy4	643	15	HCMV	HCMV	NNP
cord-259748-x7dq1sy4	643	16	deubiquitinase	deubiquitinase	NN
cord-259748-x7dq1sy4	643	17	in	in	IN
cord-259748-x7dq1sy4	643	18	promoting	promote	VBG
cord-259748-x7dq1sy4	643	19	oncogenesis	oncogenesis	NNP
cord-259748-x7dq1sy4	643	20	by	by	IN
cord-259748-x7dq1sy4	643	21	targeting	target	VBG
cord-259748-x7dq1sy4	643	22	anti	anti	JJ
cord-259748-x7dq1sy4	643	23	-	-	JJ
cord-259748-x7dq1sy4	643	24	viral	viral	JJ
cord-259748-x7dq1sy4	643	25	innate	innate	JJ
cord-259748-x7dq1sy4	643	26	immune	immune	JJ
cord-259748-x7dq1sy4	643	27	signaling	signal	VBG
cord-259748-x7dq1sy4	643	28	pathways	pathway	NNS
cord-259748-x7dq1sy4	644	1	Human	human	JJ
cord-259748-x7dq1sy4	644	2	Cytomegalovirus	Cytomegalovirus	NNP
cord-259748-x7dq1sy4	644	3	Tegument	Tegument	NNP
cord-259748-x7dq1sy4	644	4	Protein	Protein	NNP
cord-259748-x7dq1sy4	644	5	UL82	UL82	NNP
cord-259748-x7dq1sy4	644	6	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	644	7	STING	sting	NN
cord-259748-x7dq1sy4	644	8	-	-	HYPH
cord-259748-x7dq1sy4	644	9	mediated	mediate	VBN
cord-259748-x7dq1sy4	644	10	signaling	signal	VBG
cord-259748-x7dq1sy4	644	11	to	to	TO
cord-259748-x7dq1sy4	644	12	evade	evade	VB
cord-259748-x7dq1sy4	644	13	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	644	14	immunity	immunity	NN
cord-259748-x7dq1sy4	645	1	The	the	DT
cord-259748-x7dq1sy4	645	2	herpesviral	herpesviral	JJ
cord-259748-x7dq1sy4	645	3	antagonist	antagonist	NN
cord-259748-x7dq1sy4	645	4	m152	m152	NN
cord-259748-x7dq1sy4	645	5	reveals	reveal	VBZ
cord-259748-x7dq1sy4	645	6	differential	differential	JJ
cord-259748-x7dq1sy4	645	7	activation	activation	NN
cord-259748-x7dq1sy4	645	8	of	of	IN
cord-259748-x7dq1sy4	645	9	STING	sting	NN
cord-259748-x7dq1sy4	645	10	-	-	HYPH
cord-259748-x7dq1sy4	645	11	dependent	dependent	JJ
cord-259748-x7dq1sy4	645	12	IRF	IRF	NNP
cord-259748-x7dq1sy4	645	13	and	and	CC
cord-259748-x7dq1sy4	645	14	NF	NF	NNP
cord-259748-x7dq1sy4	645	15	-	-	HYPH
cord-259748-x7dq1sy4	645	16	kappaB	kappaB	NNP
cord-259748-x7dq1sy4	645	17	signaling	signal	VBG
cord-259748-x7dq1sy4	645	18	and	and	CC
cord-259748-x7dq1sy4	645	19	STING	STING	NNP
cord-259748-x7dq1sy4	645	20	's	's	POS
cord-259748-x7dq1sy4	645	21	dual	dual	JJ
cord-259748-x7dq1sy4	645	22	role	role	NN
cord-259748-x7dq1sy4	645	23	during	during	IN
cord-259748-x7dq1sy4	645	24	MCMV	MCMV	NNP
cord-259748-x7dq1sy4	645	25	infection	infection	NN
cord-259748-x7dq1sy4	646	1	Human	human	JJ
cord-259748-x7dq1sy4	646	2	cytomegalovirus	cytomegalovirus	NN
cord-259748-x7dq1sy4	646	3	-	-	HYPH
cord-259748-x7dq1sy4	646	4	encoded	encode	VBN
cord-259748-x7dq1sy4	646	5	US9	us9	JJ
cord-259748-x7dq1sy4	646	6	targets	target	NNS
cord-259748-x7dq1sy4	646	7	MAVS	MAVS	NNP
cord-259748-x7dq1sy4	646	8	and	and	CC
cord-259748-x7dq1sy4	646	9	STING	sting	VB
cord-259748-x7dq1sy4	647	1	signaling	signal	VBG
cord-259748-x7dq1sy4	647	2	to	to	TO
cord-259748-x7dq1sy4	647	3	evade	evade	VB
cord-259748-x7dq1sy4	647	4	type	type	NN
cord-259748-x7dq1sy4	648	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	648	2	interferon	interferon	VBP
cord-259748-x7dq1sy4	648	3	immune	immune	JJ
cord-259748-x7dq1sy4	648	4	responses	response	NNS
cord-259748-x7dq1sy4	649	1	Inhibition	inhibition	NN
cord-259748-x7dq1sy4	649	2	of	of	IN
cord-259748-x7dq1sy4	649	3	cGAS	cgas	JJ
cord-259748-x7dq1sy4	649	4	DNA	DNA	NNP
cord-259748-x7dq1sy4	649	5	Sensing	Sensing	NNP
cord-259748-x7dq1sy4	649	6	by	by	IN
cord-259748-x7dq1sy4	649	7	a	a	DT
cord-259748-x7dq1sy4	649	8	Herpesvirus	Herpesvirus	NNP
cord-259748-x7dq1sy4	649	9	Virion	Virion	NNP
cord-259748-x7dq1sy4	649	10	protein	protein	NN
cord-259748-x7dq1sy4	649	11	Cytoplasmic	Cytoplasmic	NNP
cord-259748-x7dq1sy4	649	12	isoforms	isoform	NNS
cord-259748-x7dq1sy4	649	13	of	of	IN
cord-259748-x7dq1sy4	649	14	Kaposi	Kaposi	NNP
cord-259748-x7dq1sy4	649	15	sarcoma	sarcoma	NN
cord-259748-x7dq1sy4	649	16	herpesvirus	herpesvirus	NN
cord-259748-x7dq1sy4	649	17	LANA	LANA	NNP
cord-259748-x7dq1sy4	649	18	recruit	recruit	VB
cord-259748-x7dq1sy4	649	19	and	and	CC
cord-259748-x7dq1sy4	649	20	antagonize	antagonize	VB
cord-259748-x7dq1sy4	649	21	the	the	DT
cord-259748-x7dq1sy4	649	22	innate	innate	JJ
cord-259748-x7dq1sy4	649	23	immune	immune	JJ
cord-259748-x7dq1sy4	649	24	DNA	dna	NN
cord-259748-x7dq1sy4	649	25	sensor	sensor	NN
cord-259748-x7dq1sy4	649	26	cGAS	cga	VBG
cord-259748-x7dq1sy4	649	27	Modulation	modulation	NN
cord-259748-x7dq1sy4	649	28	of	of	IN
cord-259748-x7dq1sy4	649	29	the	the	DT
cord-259748-x7dq1sy4	649	30	cGAS	cgas	JJ
cord-259748-x7dq1sy4	649	31	-	-	HYPH
cord-259748-x7dq1sy4	649	32	STING	sting	NN
cord-259748-x7dq1sy4	649	33	DNA	dna	NN
cord-259748-x7dq1sy4	649	34	sensing	sensing	NN
cord-259748-x7dq1sy4	649	35	pathway	pathway	NN
cord-259748-x7dq1sy4	649	36	by	by	IN
cord-259748-x7dq1sy4	649	37	gammaherpesviruses	gammaherpesviruses	NNP
cord-259748-x7dq1sy4	649	38	SARS	SARS	NNP
cord-259748-x7dq1sy4	649	39	coronavirus	coronavirus	NN
cord-259748-x7dq1sy4	650	1	papain	papain	NN
cord-259748-x7dq1sy4	650	2	-	-	HYPH
cord-259748-x7dq1sy4	650	3	like	like	JJ
cord-259748-x7dq1sy4	650	4	protease	protease	NN
cord-259748-x7dq1sy4	650	5	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	650	6	the	the	DT
cord-259748-x7dq1sy4	650	7	type	type	NN
cord-259748-x7dq1sy4	650	8	I	-PRON-	PRP
cord-259748-x7dq1sy4	650	9	interferon	interferon	VBP
cord-259748-x7dq1sy4	650	10	signaling	signal	VBG
cord-259748-x7dq1sy4	650	11	pathway	pathway	NN
cord-259748-x7dq1sy4	650	12	through	through	IN
cord-259748-x7dq1sy4	650	13	interaction	interaction	NN
cord-259748-x7dq1sy4	650	14	with	with	IN
cord-259748-x7dq1sy4	650	15	the	the	DT
cord-259748-x7dq1sy4	650	16	STING	sting	NN
cord-259748-x7dq1sy4	650	17	-	-	HYPH
cord-259748-x7dq1sy4	650	18	TRAF3-TBK1	TRAF3-TBK1	NNP
cord-259748-x7dq1sy4	650	19	complex	complex	JJ
cord-259748-x7dq1sy4	650	20	Poxviruses	Poxviruses	NNPS
cord-259748-x7dq1sy4	650	21	evade	evade	VBP
cord-259748-x7dq1sy4	650	22	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	650	23	sensing	sensing	NN
cord-259748-x7dq1sy4	650	24	through	through	IN
cord-259748-x7dq1sy4	650	25	disruption	disruption	NN
cord-259748-x7dq1sy4	650	26	of	of	IN
cord-259748-x7dq1sy4	650	27	an	an	DT
cord-259748-x7dq1sy4	650	28	mTORC1-mTORC2	mTORC1-mTORC2	NNP
cord-259748-x7dq1sy4	650	29	regulatory	regulatory	JJ
cord-259748-x7dq1sy4	650	30	circuit	circuit	NN
cord-259748-x7dq1sy4	650	31	Viral	Viral	NNP
cord-259748-x7dq1sy4	650	32	and	and	CC
cord-259748-x7dq1sy4	650	33	metazoan	metazoan	JJ
cord-259748-x7dq1sy4	650	34	poxins	poxin	NNS
cord-259748-x7dq1sy4	650	35	are	be	VBP
cord-259748-x7dq1sy4	650	36	cGAMP	cgamp	NN
cord-259748-x7dq1sy4	650	37	-	-	HYPH
cord-259748-x7dq1sy4	650	38	specific	specific	JJ
cord-259748-x7dq1sy4	650	39	nucleases	nuclease	NNS
cord-259748-x7dq1sy4	650	40	that	that	WDT
cord-259748-x7dq1sy4	650	41	restrict	restrict	VBP
cord-259748-x7dq1sy4	651	1	cGAS	cgas	JJ
cord-259748-x7dq1sy4	651	2	-	-	HYPH
cord-259748-x7dq1sy4	651	3	STING	sting	NN
cord-259748-x7dq1sy4	651	4	signalling	signal	VBG
cord-259748-x7dq1sy4	651	5	Zika	Zika	NNP
cord-259748-x7dq1sy4	651	6	virus	virus	NN
cord-259748-x7dq1sy4	651	7	elicits	elicit	VBZ
cord-259748-x7dq1sy4	651	8	inflammation	inflammation	NN
cord-259748-x7dq1sy4	651	9	to	to	TO
cord-259748-x7dq1sy4	651	10	evade	evade	VB
cord-259748-x7dq1sy4	651	11	antiviral	antiviral	JJ
cord-259748-x7dq1sy4	651	12	response	response	NN
cord-259748-x7dq1sy4	651	13	by	by	IN
cord-259748-x7dq1sy4	651	14	cleaving	cleave	VBG
cord-259748-x7dq1sy4	651	15	cGAS	cgas	NN
cord-259748-x7dq1sy4	651	16	via	via	IN
cord-259748-x7dq1sy4	651	17	NS1-caspase-1	ns1-caspase-1	XX
cord-259748-x7dq1sy4	651	18	axis	axis	NN
cord-259748-x7dq1sy4	651	19	DENV	DENV	NNP
cord-259748-x7dq1sy4	652	1	inhibits	inhibit	VBZ
cord-259748-x7dq1sy4	652	2	type	type	NN
cord-259748-x7dq1sy4	653	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	653	2	IFN	IFN	NNP
cord-259748-x7dq1sy4	653	3	production	production	NN
cord-259748-x7dq1sy4	653	4	in	in	IN
cord-259748-x7dq1sy4	653	5	infected	infected	JJ
cord-259748-x7dq1sy4	653	6	cells	cell	NNS
cord-259748-x7dq1sy4	653	7	by	by	IN
cord-259748-x7dq1sy4	653	8	cleaving	cleave	VBG
cord-259748-x7dq1sy4	653	9	human	human	JJ
cord-259748-x7dq1sy4	653	10	STING	STING	NNP
cord-259748-x7dq1sy4	653	11	Dengue	Dengue	NNP
cord-259748-x7dq1sy4	653	12	virus	virus	NN
cord-259748-x7dq1sy4	654	1	NS2B	NS2B	NNP
cord-259748-x7dq1sy4	654	2	protein	protein	NN
cord-259748-x7dq1sy4	654	3	targets	target	NNS
cord-259748-x7dq1sy4	654	4	cGAS	cga	VBG
cord-259748-x7dq1sy4	654	5	for	for	IN
cord-259748-x7dq1sy4	654	6	degradation	degradation	NN
cord-259748-x7dq1sy4	654	7	and	and	CC
cord-259748-x7dq1sy4	654	8	prevents	prevent	VBZ
cord-259748-x7dq1sy4	654	9	mitochondrial	mitochondrial	JJ
cord-259748-x7dq1sy4	654	10	DNA	dna	NN
cord-259748-x7dq1sy4	654	11	sensing	sensing	NN
cord-259748-x7dq1sy4	654	12	during	during	IN
cord-259748-x7dq1sy4	654	13	infection	infection	NN
cord-259748-x7dq1sy4	654	14	DNA	dna	NN
cord-259748-x7dq1sy4	654	15	tumor	tumor	NN
cord-259748-x7dq1sy4	654	16	virus	virus	NN
cord-259748-x7dq1sy4	655	1	oncogenes	oncogene	NNS
cord-259748-x7dq1sy4	655	2	antagonize	antagonize	VBP
cord-259748-x7dq1sy4	655	3	the	the	DT
cord-259748-x7dq1sy4	655	4	cGAS	cgas	JJ
cord-259748-x7dq1sy4	655	5	-	-	HYPH
cord-259748-x7dq1sy4	655	6	STING	sting	NN
cord-259748-x7dq1sy4	655	7	DNA	dna	NN
cord-259748-x7dq1sy4	655	8	-	-	HYPH
cord-259748-x7dq1sy4	655	9	sensing	sense	VBG
cord-259748-x7dq1sy4	655	10	pathway	pathway	NN
cord-259748-x7dq1sy4	656	1	Influenza	Influenza	NNP
cord-259748-x7dq1sy4	656	2	A	a	DT
cord-259748-x7dq1sy4	656	3	virus	virus	NN
cord-259748-x7dq1sy4	656	4	targets	target	VBZ
cord-259748-x7dq1sy4	656	5	a	a	DT
cord-259748-x7dq1sy4	656	6	cGAS	cgas	JJ
cord-259748-x7dq1sy4	656	7	-	-	HYPH
cord-259748-x7dq1sy4	656	8	independent	independent	JJ
cord-259748-x7dq1sy4	656	9	STING	sting	NN
cord-259748-x7dq1sy4	656	10	pathway	pathway	NN
cord-259748-x7dq1sy4	656	11	that	that	WDT
cord-259748-x7dq1sy4	656	12	controls	control	VBZ
cord-259748-x7dq1sy4	656	13	enveloped	envelop	VBD
cord-259748-x7dq1sy4	656	14	RNA	RNA	NNP
cord-259748-x7dq1sy4	656	15	viruses	virus	NNS
cord-259748-x7dq1sy4	656	16	Hepatitis	Hepatitis	NNP
cord-259748-x7dq1sy4	656	17	C	C	NNP
cord-259748-x7dq1sy4	656	18	virus	virus	NN
cord-259748-x7dq1sy4	657	1	NS4B	NS4B	NNP
cord-259748-x7dq1sy4	657	2	blocks	block	VBZ
cord-259748-x7dq1sy4	657	3	the	the	DT
cord-259748-x7dq1sy4	657	4	interaction	interaction	NN
cord-259748-x7dq1sy4	657	5	of	of	IN
cord-259748-x7dq1sy4	657	6	STING	sting	NN
cord-259748-x7dq1sy4	657	7	and	and	CC
cord-259748-x7dq1sy4	657	8	TBK1	TBK1	NNP
cord-259748-x7dq1sy4	657	9	to	to	TO
cord-259748-x7dq1sy4	657	10	evade	evade	VB
cord-259748-x7dq1sy4	657	11	host	host	NN
cord-259748-x7dq1sy4	657	12	innate	innate	JJ
cord-259748-x7dq1sy4	657	13	immunity	immunity	NN
cord-259748-x7dq1sy4	657	14	Hepatitis	Hepatitis	NNP
cord-259748-x7dq1sy4	657	15	C	C	NNP
cord-259748-x7dq1sy4	657	16	virus	virus	NN
cord-259748-x7dq1sy4	658	1	NS4B	NS4B	NNP
cord-259748-x7dq1sy4	658	2	protein	protein	NN
cord-259748-x7dq1sy4	658	3	targets	target	NNS
cord-259748-x7dq1sy4	658	4	STING	sting	VBP
cord-259748-x7dq1sy4	658	5	and	and	CC
cord-259748-x7dq1sy4	658	6	abrogates	abrogate	VBZ
cord-259748-x7dq1sy4	658	7	RIG	rig	NN
cord-259748-x7dq1sy4	658	8	-	-	HYPH
cord-259748-x7dq1sy4	658	9	I	i	NN
cord-259748-x7dq1sy4	658	10	-	-	HYPH
cord-259748-x7dq1sy4	658	11	mediated	mediate	VBN
cord-259748-x7dq1sy4	658	12	type	type	NN
cord-259748-x7dq1sy4	659	1	I	-PRON-	PRP
cord-259748-x7dq1sy4	660	1	interferon	interferon	NN
cord-259748-x7dq1sy4	660	2	-	-	HYPH
cord-259748-x7dq1sy4	660	3	dependent	dependent	JJ
cord-259748-x7dq1sy4	660	4	innate	innate	JJ
cord-259748-x7dq1sy4	660	5	immunity	immunity	NN
cord-259748-x7dq1sy4	660	6	Hepatitis	Hepatitis	NNP
cord-259748-x7dq1sy4	660	7	B	B	NNP
cord-259748-x7dq1sy4	660	8	virus	virus	NN
cord-259748-x7dq1sy4	660	9	polymerase	polymerase	NN
cord-259748-x7dq1sy4	660	10	disrupts	disrupt	VBZ
cord-259748-x7dq1sy4	660	11	K63-linked	k63-linke	VBN
cord-259748-x7dq1sy4	660	12	ubiquitination	ubiquitination	NN
cord-259748-x7dq1sy4	660	13	of	of	IN
cord-259748-x7dq1sy4	660	14	STING	sting	NN
cord-259748-x7dq1sy4	660	15	to	to	TO
cord-259748-x7dq1sy4	660	16	block	block	VB
cord-259748-x7dq1sy4	660	17	innate	innate	JJ
cord-259748-x7dq1sy4	660	18	cytosolic	cytosolic	JJ
cord-259748-x7dq1sy4	660	19	DNAsensing	dnasense	VBG
cord-259748-x7dq1sy4	660	20	pathways	pathway	NNS
cord-259748-x7dq1sy4	661	1	HIV-2	HIV-2	NNP
cord-259748-x7dq1sy4	661	2	/	/	SYM
cord-259748-x7dq1sy4	661	3	SIV	SIV	NNP
cord-259748-x7dq1sy4	661	4	Vpx	Vpx	NNP
cord-259748-x7dq1sy4	661	5	targets	target	VBZ
cord-259748-x7dq1sy4	661	6	a	a	DT
cord-259748-x7dq1sy4	661	7	novel	novel	JJ
cord-259748-x7dq1sy4	661	8	functional	functional	JJ
cord-259748-x7dq1sy4	661	9	domain	domain	NN
cord-259748-x7dq1sy4	661	10	of	of	IN
cord-259748-x7dq1sy4	661	11	STING	sting	NN
cord-259748-x7dq1sy4	661	12	to	to	TO
cord-259748-x7dq1sy4	661	13	selectively	selectively	RB
cord-259748-x7dq1sy4	661	14	inhibit	inhibit	VB
cord-259748-x7dq1sy4	661	15	cGAS	cgas	NN
cord-259748-x7dq1sy4	661	16	-	-	HYPH
cord-259748-x7dq1sy4	661	17	STINGmediated	stingmediated	JJ
cord-259748-x7dq1sy4	661	18	NF	NF	NNP
cord-259748-x7dq1sy4	661	19	-	-	HYPH
cord-259748-x7dq1sy4	661	20	kappaB	kappaB	NNP
cord-259748-x7dq1sy4	661	21	signalling	signal	VBG
cord-259748-x7dq1sy4	662	1	We	-PRON-	PRP
cord-259748-x7dq1sy4	662	2	thank	thank	VBP
cord-259748-x7dq1sy4	662	3	K.	K.	NNP
cord-259748-x7dq1sy4	662	4	wood	wood	NN
cord-259748-x7dq1sy4	662	5	from	from	IN
cord-259748-x7dq1sy4	662	6	Barrow	Barrow	NNP
cord-259748-x7dq1sy4	662	7	Neurological	Neurological	NNP
cord-259748-x7dq1sy4	662	8	Institute	Institute	NNP
cord-259748-x7dq1sy4	662	9	for	for	IN
cord-259748-x7dq1sy4	662	10	discussions	discussion	NNS
cord-259748-x7dq1sy4	662	11	and	and	CC
cord-259748-x7dq1sy4	662	12	editing	editing	NN
cord-259748-x7dq1sy4	662	13	.	.	.
cord-259748-x7dq1sy4	663	1	The	the	DT
cord-259748-x7dq1sy4	663	2	authors	author	NNS
cord-259748-x7dq1sy4	663	3	declare	declare	VBP
cord-259748-x7dq1sy4	663	4	that	that	IN
cord-259748-x7dq1sy4	663	5	the	the	DT
cord-259748-x7dq1sy4	663	6	research	research	NN
cord-259748-x7dq1sy4	663	7	was	be	VBD
cord-259748-x7dq1sy4	663	8	conducted	conduct	VBN
cord-259748-x7dq1sy4	663	9	in	in	IN
cord-259748-x7dq1sy4	663	10	the	the	DT
cord-259748-x7dq1sy4	663	11	absence	absence	NN
cord-259748-x7dq1sy4	663	12	of	of	IN
cord-259748-x7dq1sy4	663	13	any	any	DT
cord-259748-x7dq1sy4	663	14	commercial	commercial	JJ
cord-259748-x7dq1sy4	663	15	or	or	CC
cord-259748-x7dq1sy4	663	16	financial	financial	JJ
cord-259748-x7dq1sy4	663	17	relationships	relationship	NNS
cord-259748-x7dq1sy4	663	18	that	that	WDT
cord-259748-x7dq1sy4	663	19	could	could	MD
cord-259748-x7dq1sy4	663	20	be	be	VB
cord-259748-x7dq1sy4	663	21	construed	construe	VBN
cord-259748-x7dq1sy4	663	22	as	as	IN
cord-259748-x7dq1sy4	663	23	a	a	DT
cord-259748-x7dq1sy4	663	24	potential	potential	JJ
cord-259748-x7dq1sy4	663	25	conflict	conflict	NN
cord-259748-x7dq1sy4	663	26	of	of	IN
cord-259748-x7dq1sy4	663	27	interest	interest	NN
cord-259748-x7dq1sy4	663	28	.	.	.
cord-259748-x7dq1sy4	664	1	Copyright	copyright	NN
cord-259748-x7dq1sy4	664	2	©	©	NN
cord-259748-x7dq1sy4	664	3	2020	2020	CD
cord-259748-x7dq1sy4	664	4	Wan	Wan	NNP
cord-259748-x7dq1sy4	664	5	,	,	,
cord-259748-x7dq1sy4	664	6	Jiang	Jiang	NNP
cord-259748-x7dq1sy4	664	7	and	and	CC
cord-259748-x7dq1sy4	664	8	Hao	Hao	NNP
cord-259748-x7dq1sy4	664	9	.	.	.
cord-259748-x7dq1sy4	665	1	This	this	DT
cord-259748-x7dq1sy4	665	2	is	be	VBZ
cord-259748-x7dq1sy4	665	3	an	an	DT
cord-259748-x7dq1sy4	665	4	open	open	JJ
cord-259748-x7dq1sy4	665	5	-	-	HYPH
cord-259748-x7dq1sy4	665	6	access	access	NN
cord-259748-x7dq1sy4	665	7	article	article	NN
cord-259748-x7dq1sy4	665	8	distributed	distribute	VBN
cord-259748-x7dq1sy4	665	9	under	under	IN
cord-259748-x7dq1sy4	665	10	the	the	DT
cord-259748-x7dq1sy4	665	11	terms	term	NNS
cord-259748-x7dq1sy4	665	12	of	of	IN
cord-259748-x7dq1sy4	665	13	the	the	DT
cord-259748-x7dq1sy4	665	14	Creative	Creative	NNP
cord-259748-x7dq1sy4	665	15	Commons	Commons	NNP
cord-259748-x7dq1sy4	665	16	Attribution	Attribution	NNP
cord-259748-x7dq1sy4	665	17	License	License	NNP
cord-259748-x7dq1sy4	665	18	(	(	-LRB-
cord-259748-x7dq1sy4	665	19	CC	CC	NNP
cord-259748-x7dq1sy4	665	20	BY	BY	NNP
cord-259748-x7dq1sy4	665	21	)	)	-RRB-
cord-259748-x7dq1sy4	665	22	.	.	.
cord-259748-x7dq1sy4	666	1	The	the	DT
cord-259748-x7dq1sy4	666	2	use	use	NN
cord-259748-x7dq1sy4	666	3	,	,	,
cord-259748-x7dq1sy4	666	4	distribution	distribution	NN
cord-259748-x7dq1sy4	666	5	or	or	CC
cord-259748-x7dq1sy4	666	6	reproduction	reproduction	NN
cord-259748-x7dq1sy4	666	7	in	in	IN
cord-259748-x7dq1sy4	666	8	other	other	JJ
cord-259748-x7dq1sy4	666	9	forums	forum	NNS
cord-259748-x7dq1sy4	666	10	is	be	VBZ
cord-259748-x7dq1sy4	666	11	permitted	permit	VBN
cord-259748-x7dq1sy4	666	12	,	,	,
cord-259748-x7dq1sy4	666	13	provided	provide	VBD
cord-259748-x7dq1sy4	666	14	the	the	DT
cord-259748-x7dq1sy4	666	15	original	original	JJ
cord-259748-x7dq1sy4	666	16	author(s	author(s	NNP
cord-259748-x7dq1sy4	666	17	)	)	-RRB-
cord-259748-x7dq1sy4	666	18	and	and	CC
cord-259748-x7dq1sy4	666	19	the	the	DT
cord-259748-x7dq1sy4	666	20	copyright	copyright	NN
cord-259748-x7dq1sy4	666	21	owner(s	owner(s	NNP
cord-259748-x7dq1sy4	666	22	)	)	-RRB-
cord-259748-x7dq1sy4	666	23	are	be	VBP
cord-259748-x7dq1sy4	666	24	credited	credit	VBN
cord-259748-x7dq1sy4	666	25	and	and	CC
cord-259748-x7dq1sy4	666	26	that	that	IN
cord-259748-x7dq1sy4	666	27	the	the	DT
cord-259748-x7dq1sy4	666	28	original	original	JJ
cord-259748-x7dq1sy4	666	29	publication	publication	NN
cord-259748-x7dq1sy4	666	30	in	in	IN
cord-259748-x7dq1sy4	666	31	this	this	DT
cord-259748-x7dq1sy4	666	32	journal	journal	NN
cord-259748-x7dq1sy4	666	33	is	be	VBZ
cord-259748-x7dq1sy4	666	34	cited	cite	VBN
cord-259748-x7dq1sy4	666	35	,	,	,
cord-259748-x7dq1sy4	666	36	in	in	IN
cord-259748-x7dq1sy4	666	37	accordance	accordance	NN
cord-259748-x7dq1sy4	666	38	with	with	IN
cord-259748-x7dq1sy4	666	39	accepted	accepted	JJ
cord-259748-x7dq1sy4	666	40	academic	academic	JJ
cord-259748-x7dq1sy4	666	41	practice	practice	NN
cord-259748-x7dq1sy4	666	42	.	.	.
cord-259748-x7dq1sy4	667	1	No	no	DT
cord-259748-x7dq1sy4	667	2	use	use	NN
cord-259748-x7dq1sy4	667	3	,	,	,
cord-259748-x7dq1sy4	667	4	distribution	distribution	NN
cord-259748-x7dq1sy4	667	5	or	or	CC
cord-259748-x7dq1sy4	667	6	reproduction	reproduction	NN
cord-259748-x7dq1sy4	667	7	is	be	VBZ
cord-259748-x7dq1sy4	667	8	permitted	permit	VBN
cord-259748-x7dq1sy4	667	9	which	which	WDT
cord-259748-x7dq1sy4	667	10	does	do	VBZ
cord-259748-x7dq1sy4	667	11	not	not	RB
cord-259748-x7dq1sy4	667	12	comply	comply	VB
cord-259748-x7dq1sy4	667	13	with	with	IN
cord-259748-x7dq1sy4	667	14	these	these	DT
cord-259748-x7dq1sy4	667	15	terms	term	NNS
cord-259748-x7dq1sy4	667	16	.	.	.