id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354762-3a3a3ku9	Afsar, Cigdem Usul	SARS-CoV-2 (COVID-19): INTERFERON-EPSILON MAY BE RESPONSIBLE OF DECREASED MORTALITY IN FEMALES	2020-06-02		.txt	text/plain	987	70	54	title: SARS-CoV-2 (COVID-19): INTERFERON-EPSILON MAY BE RESPONSIBLE OF DECREASED MORTALITY IN FEMALES IFN is particularly expressed in epithelial cells and it is essential in skin and mucosal immunity (lung, intestines and reproductive tissues) of all African and Asian pangolin species (Choo and others, 2016) . IFN, like the other type I IFNs, might be responsible of decreased mortality in females because of its antiviral effects. The JAK/STAT pathway responds to type I IFN secreted from neighboring cells and SARS-CoV proteins have been shown to affect this pathway before (Frieman and Baric, 2008) . JAK-STAT signal blocking by baricitinib (a selective JAK1 and JAK2 inhibitor) produces an impairment of IFN-mediated antiviral response, with a potential facilitating effect on the evolution of SARS-CoV-2 infection. Interferon-epsilon protects the female reproductive tract from viral and bacterial infection	./cache/cord-354762-3a3a3ku9.txt	./txt/cord-354762-3a3a3ku9.txt