id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353062-c6luoo3m	Lauber, C	Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells	2015-09-01		.txt	text/plain	5449	311	55	To address both tissue and subtype specificity in the interferon response, we treated primary human hepatocytes and airway epithelial cells with IFNα, IFNλ3 or IFNλ4 and assessed interferon mediated gene regulation using transcriptome sequencing. 23 In order to determine whether IFNλ4 can induce an alternative set of genes, that are not induced in the classical IFN response, we have compared the transcriptional response after IFNα, IFNλ3 and IFNλ4 stimulation in both primary human hepatocytes (PHH) and primary human airway epithelial (HAE) cells using transcriptome sequencing (RNA-seq). Compared with a recently published microarray analysis of type I and type III IFN responses in PHH, which used similar statistical thresholds but substantially higher IFNλ concentrations than our study (1000 ng ml − 1 ), 11 our RNA-seq data provide a more complete estimate of the IFN response (87 versus 50 genes significantly regulated by IFNλ3).	./cache/cord-353062-c6luoo3m.txt	./txt/cord-353062-c6luoo3m.txt