id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351845-bli3qm8w	Prasad, Kartikay	Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective	2020-06-26		.txt	text/plain	4626	293	46	Towards this goal, in this study, we have generated a human-SARS-CoV-2 interactome based on recently published RNA-Seq analysis of human adenocarcinomic alveolar basal epithelial (A549) cells infected with SARS-CoV-2, and identified disease-related functional genes that will provide the insights into the patho-J o u r n a l P r e -p r o o f 4 mechanisms of COVID-19. Overall, the analysis demonstrated that the upregulated genes are mainly linked to the host response to SARS-CoV-2 infection, type I interferon signaling and the cytokine-mediated signaling pathway. The PPI network analysis indicates that the pathways are enriched in host response to virus infection, type I interferons signaling, and cytokine activation. [74] reported high SARS-CoV-2 loads very early during infection, suggesting that the virus may have developed arsenals that is able to delay the IFN response by inhibiting innate immune signaling.	./cache/cord-351845-bli3qm8w.txt	./txt/cord-351845-bli3qm8w.txt