id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-348684-xbxwpmxq	Liu, Bao-qin	Ubiquitination modification: critical regulation of IRF family stability and activity	2020-10-30		.txt	text/plain	5231	258	32	Interferon regulatory factors (IRFs) play pivotal and critical roles in innate and adaptive immune responses; thus, precise and stringent regulation of the stability and activation of IRFs in physiological processes is necessary. Knowledge of how these proteins function and interact with IRFs may provide a better understanding of the regulation of IRFs in immune responses or other biological processes and exciting targets for the development of drugs aimed at regulating the functions of specific E3 ligases or DUBs. Ubiquitination is a type of reversible cellular protein PTM. Furthermore, K63-linked polyubiquitination and monoubiquitination, the second most common type of ubiquitin linkage, mediate proteasome-independent effects, which play an important role in activating many components of different signaling pathways and participate in many biological processes (Ning et al., 2011) . c-Cbl, a member of the Cbl (Casitas B-lineage lymphoma) family, negatively regulates IRF3 protein stability by interacting with the C-terminal domain of IRF3 via its TKB (tyrosine kinase binding) domain and promotes K48-linked polyubiquitination-dependent proteasomal degradation of IRF3 (Zhao et al., 2016) .	./cache/cord-348684-xbxwpmxq.txt	./txt/cord-348684-xbxwpmxq.txt