id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347946-i6kx3n6m	Raison, Charles L	Pathogen–Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance	2016-09-15		.txt	text/plain	18693	670	31	Like sickness behavior, depression in response to immune activation aided in host defense both directly (ie, raised body temperature and energy conservation behaviors) and indirectly (social avoidance, energy conservation, and hypervigilance; Raison and Miller, pathogenhost defense theory of depression [PATHOS-D]) Adaptive explanations for associations between MDD and altered immune functioning are not considered (frequent unexamined assumption of researchers working on proximal mechanisms) Toll-like receptor (TLR) mRNA and protein have been reported to be elevated in both the periphery and CNS of individuals with MDD (Hung et al, 2014 (Hung et al, , 2015 Keri et al, 2014; van Dooren et al, 2016) , with some evidence suggesting that successful pharmaco-or psychotherapy reduces peripheral TLR activity (Keri et al, 2014; Hung et al, 2015) .	./cache/cord-347946-i6kx3n6m.txt	./txt/cord-347946-i6kx3n6m.txt