id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343515-fad1yyqx	Felgenhauer, Ulrike	Inhibition of SARS–CoV-2 by type I and type III interferons	2020-10-09		.txt	text/plain	2934	157	53	For SARS-CoV-2 (dark gray bars), statistically significant negative correlation coefficients (CC) were obtained for both cell lines, indicating that viral replication is increasingly inhibited by IFN-a. Observations were similar when the input MOI was reduced to 0.001 (Fig. S1 ), except that titers of SARS-CoV-1 in Calu-3 cells were already very low in the absence of any IFN-a, resulting in a nonsignificant effect of additional IFN. Our data thus indicate that (i) if anything, ruxolitinib is an enhancer rather than an inhibitor of SARS-CoV-2 multiplication, and (ii) the boosting effect is most likely due to inhibition of the antiviral JAK/ STAT signaling pathway, because it is not present in the IFN induction-deficient Vero E6 cells. For the statistical testing of the dose-response effect of IFN (type I and III) against SARS-coronaviruses, the typical regression procedures were not applicable because of several values below the detection limit and some ties in the data.	./cache/cord-343515-fad1yyqx.txt	./txt/cord-343515-fad1yyqx.txt