id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342800-62jklwiy	Xu, Shuqin	mRNA Vaccine Era—Mechanisms, Drug Platform and Clinical Prospection	2020-09-09		.txt	text/plain	13579	706	43	The RNActive ® vaccine platform designed by CureVac used co-delivered RNA and protamine complex as the adjuvant to induce Th1 T cell responses, and naked, unmodified, and sequence-optimized mRNA as the antigen to develop mRNA vaccines [54] . used LNP to deliver self-amplified RNA vaccines, which caused the mRNA expression level in mice to be significantly higher than that of naked mRNA, CD4 + , and CD8 + T cell immune responses were also effectively induced. Overall development steps of those vaccines are (1) constructing the core antigen-encoding mRNA sequence optimized or combined based on selected antigen(s) from the target pathogen; (2) trying and choosing a proper combination of mRNA construction type, adjuvants, carrier materials and the route of administration; (3) detecting in vivo expression of the encoded antigen and the level of elicited immune responses; (4) providing research and demonstrations of immune induction mechanisms.	./cache/cord-342800-62jklwiy.txt	./txt/cord-342800-62jklwiy.txt