id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342189-ya05m58o	Banerjee, Abhik K.	SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses	2020-10-08		.txt	text/plain	11469	647	55	Here, we comprehensively define the interactions between each SARS-CoV-2 protein and human RNAs. We show that 10 viral proteins form highly specific interactions with mRNAs or ncRNAs, including those involved in progressive steps of host cell protein production. We show J o u r n a l P r e -p r o o f 5 that NSP16 binds to the mRNA recognition domains of the U1 and U2 RNA components of the spliceosome and acts to suppress global mRNA splicing in SARS-CoV-2-infected human cells. We identified several pathogenic functions of SARS-CoV-2 in human cells -including global inhibition of host mRNA splicing, protein translation, and membrane protein trafficking -and described the molecular mechanisms by which the virus acts to disrupt these essential cell processes.	./cache/cord-342189-ya05m58o.txt	./txt/cord-342189-ya05m58o.txt