id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339991-k8z6v2vx	Rong, Q.	Multiple mechanisms for HSV-1 induction of interferon α production by peripheral blood mononuclear cells	2003		.txt	text/plain	5571	273	48	UV-inactivated, infectious, and other forms of herpes simplex virus 1 (HSV-1) induced interferon (IFN) production by different routes in myeloid origin mononuclear cells (MOMC) (consisting predominantly of monocytes). Comparison of the activities of different strains of infectious HSV, UV-inactivated HSV, and a mutant HSV incapable of penetration (K T) [9] and results of treatment with a mannose receptor antagonist indicate that there are more than one mechanism for HSV induction of interferon in the MOMC origin cell populations. The greater response to UV-inactivated virus suggests that non-infectious virions and possibly HSV infected cell debris are the more potent activators of IFN α production and that replicating virus can limit the induction of interferon production as a means of escaping host protection. Interferons and the colony-stimulating factors IL-3 and GM-CSF enhance the ifn-alpha response in human blood leucocytes induced by herpes simplex virus	./cache/cord-339991-k8z6v2vx.txt	./txt/cord-339991-k8z6v2vx.txt