id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335384-co2fgz26	Lobo‐Silva, Diogo	Interferon‐β regulates the production of IL‐10 by toll‐like receptor‐activated microglia	2017-06-15		.txt	text/plain	7144	385	50	These differential responses were not dependent on the dose of agonist used to stimulate microglia, as increasing the doses of TLR ligands did not result in enhanced secretion of IL-10, nor of TNF (Supporting Information, Figure 1 ). Considering the cytokine landscape obtained upon TLR3 triggering of microglia (Figure 1 ), if such mechanism was operating, the best candidate molecule would be IFN-b, as it is strongly induced by TLR3 ( Figure 1g ) and it has been described to potentiate IL-10 in studies performed with bone marrow-derived macrophages and dendritic cells (Iyer, Ghaffari, & Cheng, 2010; F. Co-stimulation of microglia with TLR3 enhanced IL-10 production via IFN-b, thus opening a novel mechanism underlying its beneficial role in MS and being a possible tool to locally regulate inflammatory responses.	./cache/cord-335384-co2fgz26.txt	./txt/cord-335384-co2fgz26.txt