id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328804-f7etlk5i	Olofsson, Peter	Arthritis suppression by NADPH activation operates through an interferon-β pathway	2007-05-09		.txt	text/plain	7779	368	48	Hence, global gene-expression profiling on inguinal lymph nodes was performed 10 days after the induction of pristane-induced arthritis (PIA) and phytol administration. To analyze the in vivo effects of the NADPH oxidase activator phytol versus the effects of the arthritis-inducing compound pristane, global gene-expression profiling was performed. By studying gene-expression profiles and performing pathway analysis, we have identified the importance of an IFN-β-dependent pathway as one molecular mechanism for the arthritis-ameliorating efficacy of NADPH oxidaseactivating compounds. To obtain a more detailed understanding of the molecular mechanism of this regulation, gene-expression profiling experiments were performed on inguinal lymph nodes from rats with pharmacologically (phytol) and genetically (Ncf1) modified NADPH oxidase activity. In this study, we used global gene-expression analysis and quantitative real-time PCR techniques in four separate arthritis experiments in rats to investigate the downstream effects of preventive arthritis treatment with the NADPH oxidase activator phytol.	./cache/cord-328804-f7etlk5i.txt	./txt/cord-328804-f7etlk5i.txt