id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321992-lk2ao6m8	Annamalai, Thavamathi	Age-dependent variation in innate immune responses to porcine epidemic diarrhea virus infection in suckling versus weaned pigs	2015-12-15		.txt	text/plain	8539	472	58	In the present study, we investigated the innate immune responses such as cytokine and NK cell activity as well as changes in frequencies of T cells to examine if differences coincide with the higher disease severity of suckling versus weaned pigs. The infected weaned pigs also had significantly higher NK cell frequencies in blood and ileum at PID 5 (P < 0.05) compared to infected suckling pigs ( Fig. 2A and B) . In infected suckling and weaned groups, peak IFN␣, IL-12 and TNF␣ levels coincided with onset of diarrhea and fecal PEDV RNA shedding and peak serum PEDV RNA titers (PIDs 1 and 3, respectively); and (4) Frequencies of CD3+CD4+ T cells were significantly higher in ileum of suckling pigs than in weaned pigs, whereas there was no difference in frequency of CD3+CD8+ T cells.	./cache/cord-321992-lk2ao6m8.txt	./txt/cord-321992-lk2ao6m8.txt