id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311718-z64g8fce	Chu, Yeonjeong	Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers	2020-10-16		.txt	text/plain	1967	115	43	Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. We designed and synthesized a series of arylpiperazine derivatives as interferon inducers  We tested different linker system and carbonyl moiety resulted in increase of potency  5i exhibited the activity of interferon inducer with EC 50 of 13.1 μM and no cytotoxicity  5i initiated immune responses by mediating type I IFN signaling Based on these important characteristics of the ARP skeleton, we designed and synthesized a series of 2,3-dichloro ARP derivatives by further N-modification on piperazine part with different linker moiety such as thiourea, urea, and carbonyl functional group in order to assess structure-activity relationship (SAR; Figure 1b All the synthesized compounds were evaluated using ISRE reporter assay on THP-1 human monocyte cells for monitoring immune response.	./cache/cord-311718-z64g8fce.txt	./txt/cord-311718-z64g8fce.txt