id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304330-egvdvvtx	Damsky, William	When interferon tiptoes through COVID-19: Pernio-like lesions and their prognostic implications during SARS-CoV-2 infection	2020-06-19		.txt	text/plain	442	32	56	William Damsky MD, PhD 1,* , Danielle Peterson MD 1 Brett King MD, PhD 1,* 4 5 has suggested that SARS-CoV-2 infection is sometimes characterized by a muted anti-40 viral Type I and III interferon (IFN) response, 6,7 which may explain progression to 41 severe clinical manifestations in some patients; a robust Type I IFN response was 42 associated with rapid viral clearance and bland disease course. Together, these data suggest that COVID toes may be a 46 marker of patients that are able to mount a robust anti-viral immune response to SARS-CoV-2 and prognosticate a milder course of COVID-19. 6,7 Therefore, we hypothesize that pernio-like lesions, which can 81 occur with elevated Type I IFN signaling, are the result of a robust anti-viral response in patients with COVID-19, and, therefore, are associated with a favorable disease course, 83 as observed in these patients. Pernio-like skin lesions associated 101 with COVID-19: a case series of 318 patients from 8 countries	./cache/cord-304330-egvdvvtx.txt	./txt/cord-304330-egvdvvtx.txt