id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302340-pw2xqhwa	Feeley, Eric M.	IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry	2011-10-27		.txt	text/plain	9235	553	52	Therefore, we have hypothesized that IFITM proteins inhibit susceptible virus families (Orthomyxoviridae, Flaviviridae, Rhabdoviridae, Filoviridae, and Coronaviridae) during the envelope-dependent early phase of the infection cycle, which extends from viral binding to cell surface receptors through the creation of the fusion pore between viral and host membranes [14, 19, 20] . B) MDCK cells stably overexpressing IFITM3 (MDCK-IFITM3) or empty vector control cells (MDCK-Vector) were exposed for 2 h to viral pseudoparticles containing a BLAM-Vpr and expressing either the HA and NA envelope proteins of Influenza A virus (WSN/33, H1N1pp) or the VSV-G envelope protein (VSV-Gpp), then loaded with CCF2. Our assays showed that incoming influenza A viruses were retained in the expanded acidic compartments of both the IFITM3 overexpressing cell lines as well as the IFN-c-treated MEFs, and that IFITM3 partially localized to these structures ( Fig. 2-4, S2-4, S6) .	./cache/cord-302340-pw2xqhwa.txt	./txt/cord-302340-pw2xqhwa.txt