id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-300648-ixiam7qr	Zhu, Xun	IFITM3‐containing exosome as a novel mediator for anti‐viral response in dengue virus infection	2014-08-30		.txt	text/plain	8229	367	47	At 24 h post infection when the infected cells were examined by real-time RT-PCR assay, strikingly, DENV-2 infection was suppressed potently by the IFITM3-containing exosomes in a dose-dependent manner in parental HeLa cells (Fig. 4A ) or in HeLa cells with endogenous IFITM3 knocked down (Fig. 4C) , and the copy number of DENV-2 viral RNA was reduced in the culture supernatant ( Fig. 4B and D), indicating that the observed antiviral effect was mediated by the exosome-transferred IFITM3. To verify that the enhanced antiviral effects caused by IFITM3-exosome transfer was a result of IFITM3 action rather than a stimulated paracrine IFNs response, the concentration of human IFN-α/β in culture supernatant of HeLa cells or HeLa-siIFITM3 cells treated with IFITM3laden exosomes was measured with ELISA by using Sendai virus (SeV; 100 HAU ml −1 ) as a positive stimulus control.	./cache/cord-300648-ixiam7qr.txt	./txt/cord-300648-ixiam7qr.txt