id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299733-4mpz5l9e	Mitchell, William M.	Discordant Biological and Toxicological Species Responses to TLR3 Activation	2014-04-30		.txt	text/plain	6164	343	45	The mechanism of this differential response is consistent with a relative down-regulation of the NF-κB inflammatory cytokine induction pathway in the cynomolgus monkey and humans, but not observed systemically in rat. Primary protein sequences for the human (GenBank U88879); monkey species, including Macaca mulatta (Gen-Bank BAG55034.1 and AY864735), Macaca fasicularis ajp.amjpathol.org -The American Journal of Pathology (GenBank BAG55033.1), Papio anubis (XP_003899477), Callithrix jacchus (JAB01765.1), and Saimiri boliviensis (XP_003899477); and rodents, including the house mouse (GenBank AF355152/Mus musculus) and rat (GenBank AB116229/Rattus norvegicus), dog (GenBank XP_ 005630024/Canis lupus familiaris), and rabbit (GenBank ABB76310/Oryctolagus cuniculus) were aligned using Crystal W software version 10.1.2 provided by DNAStar (Madison, WI). The unexpected differential toxicities observed between the rat and a nonhuman primate prompted an examination of inflammatory cytokines (g-IFN, TNF-a, and IL-12p70) associated with infusion of a TLR3 agonist, rintatolimod.	./cache/cord-299733-4mpz5l9e.txt	./txt/cord-299733-4mpz5l9e.txt