id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298259-r9rn0yyz	Omatsu, Tsutomu	Induction and sequencing of Rousette bat interferon α and β genes	2008-07-15		.txt	text/plain	2981	202	63	To investigate the function of type I IFNs upon viral infection in bats, the nucleic acid, and amino acid sequences of Egyptian Rousette (Rousettus aegyptiacus) IFN-α and -β were characterized. Stimulation of bat primary kidney cells (BPKCs) and bat lung cell lines, Tb-1 Lu, with polyinosinic–polycytidylic acid (poly(I:C)) or exogenous bat type I IFNs resulted in increased type I IFNs mRNA expression in BPKCs, but not in Tb-1 Lu. Characterization of the bat IFN-α and -β genes allows understanding of the immune responses upon stimulation in different tissues, thus providing practical strategies for control and treatment of clinically important diseases. These results are important especially for the virus infection, and suggest that future molecular studies on virus infection experiment of bats in vitro will require careful consideration of the differences of type I IFN expression patterns in different cell types. These data suggested that Ebola virus might evade the anti-viral activity of IFNs in bat cells.	./cache/cord-298259-r9rn0yyz.txt	./txt/cord-298259-r9rn0yyz.txt