id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277409-q5wx313k	Resende, Lucilene Aparecida	Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features before and after Leishmania chagasi-Challenge	2016-08-24		.txt	text/plain	7939	372	46	Additionally, LbSap has been shown to induce a prominent pro-inflammatory immune response characterized by increased levels of both IL-12 and IFN-γ and decreased levels of TGF-β by peripheral blood mononuclear cells (PBMCs), which were associated with parasite control in dogs [26] . Previous studies of dogs using the "LbSapSal" vaccine displayed higher counts of circulating and Leishmania-specific CD8 + T cells in addition to high nitric oxide (NO) production [22] and reduction of splenic parasite load [27] . chagasi-challenge (T 90) demonstrated that "LbSapSal" group showed a significant increase of TNF-α levels (P<0.05) upon VSA-stimulation as compared to "Sal" and "LbSal" groups ( Fig 1A, middle panel) . The results observed at the post-vaccination period (T 3rd ) demonstrated that the "LbSal" group showed a significant reduction in the IL-10 levels (P<0.05) upon VSA-stimulation as compared to the "Sal" group ( Fig 2B, middle panel) .	./cache/cord-277409-q5wx313k.txt	./txt/cord-277409-q5wx313k.txt