id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265941-eff4le0g	Eng, Vik Ven	The diverse roles of RIP kinases in host-pathogen interactions	2020-08-26		.txt	text/plain	11836	657	34	Nevertheless, the signal transduction that follows pathogen recognition elicits numerous defence mechanisms, including the induction of inflammatory cytokine, chemokine and interferon production, activation of programmed cell death pathways, and inevitably an adaptive immune response, all of which contribute to pathogen control and elimination [1] . As inhibition of necroptosis does not affect IAV control, while Mlkl-/-Fadd-/-mice exhibit marked susceptibility to IAV-induced lethality [78] , it signifies that RIPK1/3-mediated apoptosis is a major form of host protection against IAV infection. A number of studies have used purified pathogen components such as LPS to investigate the outcomes of RIPK1/3-mediated inflammasome signaling, which appear to be largely dependent on cell type, stimulus, and the availability or functional activity of certain host signaling proteins [65, [123] [124] [125] [126] [127] . Overall this suggests that RIPK2 plays an important role in both innate and adaptive immunity to infection [137, 151] , and that RIPK2 was mediating these responses via NOD1/2 and not directly via TLR activation [140] .	./cache/cord-265941-eff4le0g.txt	./txt/cord-265941-eff4le0g.txt