id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255709-tm3we5sd	Mossel, Eric C.	Synergistic Inhibition of Sars-Coronavirus Replication by Type I and Type II IFN	2006		.txt	text/plain	893	60	60	It has been previously shown that treatment of cells with both type I and type II IFN produces an antiviral state greater in magnitude than can be explained by additive effects alone. Cytopathic effect (CPE) was extensive in vehicle-treated groups infected with either SARS-CoV strain at 120 hpi ( Fig. 2A and 2E) , as evident by the reduced monolayer staining with crystal violet. However, the CPE profile observed in Calu-3 cells suggests that the synergistic inhibitory effect on SARS-CoV replication by IFN-β and IFN-γ is not Vero E6 cell specific. It has been known for more than 25 years that treatment of cells with type I and type II IFN potentiates the antiviral response to levels greater than can be explained by simple additive effects. Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gamma	./cache/cord-255709-tm3we5sd.txt	./txt/cord-255709-tm3we5sd.txt