id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252528-rgnhfcbx	Du, Fenghe	COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness	2020-07-16		.txt	text/plain	8437	359	30	• Anti-inflammatory therapies, including tocilizumab, chloroquine, and hydroxychloroquine, which can be promising treatment to control excessive cytokine release in severe COVID-19, have the potential to reduce the risk of vascular thrombotic events, but more clinical data are needed for optimum instruction of drug use and drug selection. By interpreting the pathological mechanisms, we aim to illustrate that excessive pro-inflammatory cytokine release and potential ACE2 down-regulation can promote the hypercoagulable state in severe COVID19 , and propose that the anti-inflammatory medications, as well as ACEI/ARB, can benefit severe COVID-19 patients by reducing the risk of vascular thrombotic events.	./cache/cord-252528-rgnhfcbx.txt	./txt/cord-252528-rgnhfcbx.txt