id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016343-wc3i54fc	Frese, Michael	Interferon-Induced Effector Proteins and Hepatitis C Virus Replication	2008		.txt	text/plain	10097	503	45	RdRp, RNA-dependent RNA polymerase; IRES, internal ribosome entry site; 5BSL3.2, stem loop 3.2 within the coding sequence of NS5B normally result in the production of type I IFNs and the subsequent expression of IFN-induced effector proteins, which in turn would establish an antiviral state in the IFN-producing cell itself and in neighboring cells. Since MxA has the ability to efficiently inhibit a variety of different RNA viruses, MxA was the first IFN-induced effector protein to be analyzed for its antiviral activity in the HCV replicon system (Frese et al., 2001) . Rather indirect evidence that the OAS/RNase L pathway may indeed target HCV replication/translation was recently provided by Taguchi and co-workers, who reported that the N-terminal portion of NS5A (amino acids 1 to 148), which lacks the so-called PKR-binding domain, binds to OAS proteins and there by counteract the antiviral activity of IFN-α (Taguchi et al., 2004) .	./cache/cord-016343-wc3i54fc.txt	./txt/cord-016343-wc3i54fc.txt