id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-008821-rxzgfk1k	A. Lucchiari, Maria	In vivo depletion of interferon-gamma leads to susceptibility of A/J mice to mouse hepatitis virus 3 infection	2011-11-02		.txt	text/plain	2416	97	45	Abbreviations; MHV3 = mouse hepatitis virus 3; IFN = interferon; Fes = fetal calf serum; PFU = plaque-forming units; ip = intraperitoneally; Ab = antibodies; PBS = phosphate buffer solution against our strain of MHV3 is acquired after immunization and the mechanism involved is dependent on the IFN -y synthesis and the macrophage sensitivity to IFN-y (9). Although, in view of the crucial regulatory function of CD4 cells and the important role of CDS cells as cytotoxic effector cells during a virusspecific immune response, the results cannot unequivocally exclude the interpretation that susceptibility of the immunosuppressed animals may be due to the absence of proper immune effector mechanisms, the lack of clearance of the virus in the peritoneum and liver of AI] treated and infected mice (Figure 1) , which leads to high rates of mortality (Table 1) , may be attributed to the lack of IFN-y in the serum or peritoneal exudate of them (Fig. 3) , which has been shown in vitro to be effective to restrict the MHV3 growth in target cells such as macrophages (6, 7, 9) .	./cache/cord-008821-rxzgfk1k.txt	./txt/cord-008821-rxzgfk1k.txt