id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007646-yh8zi1ee	Weiss, R.C.	Effect of recombinant human interferon-alpha in vitro and in vivo on mitogen-induced lymphocyte blastogenesis in cats()	2002-11-12		.txt	text/plain	3828	199	48	The effect of recombinant human interferon-alpha (rHuIFN-α) in vitro and in vivo on mitogen-induced lymphocyte blastogenesis was evaluated in specific-pathogen-free cats. Pre-incubation of isolated feline peripheral blood lymphocytes (PBL) in vitro with either 104 or 103 International Units (U) of rHuIFN-o~ for 24 h significantly suppressed (P < 0.001 and 0.01, respectively) blastogenic responses to the phytomitogens concanavalin A (Con A) and pokeweed mitogen (PWM). Pre-incubation of isolated feline peripheral blood lymphocytes (PBL) in vitro with either 104 or 103 International Units (U) of rHuIFN-o~ for 24 h significantly suppressed (P < 0.001 and 0.01, respectively) blastogenic responses to the phytomitogens concanavalin A (Con A) and pokeweed mitogen (PWM). Although the suppressive mechanism (s) associated with rHuIFN-c~ on DNA synthesis and lymphocyte blastogenesis were not investigated in our study, it is possible that high doses of IFN in vitro enhanced lectin-binding on lymphocytes and stimulated suppressor cell activities.	./cache/cord-007646-yh8zi1ee.txt	./txt/cord-007646-yh8zi1ee.txt